                         SEQUENCE LISTING

<110>  arGEN-X B.V.
 
<120>  ANTI C-MET ANTIBODIES

<130>  NLW/P114515WO01

<160>  206   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  1

Asp Tyr Ala Met Thr 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  2

Thr Ile Ser Trp Asn Asp Ile Asn Thr Tyr Tyr Ala Glu Ser Met Lys 
1               5                   10                  15      


Asp 
    


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  3

Arg Arg Asp Asn Tyr Tyr Gly Thr Ser Gly Glu Tyr Asp Tyr 
1               5                   10                  


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  4

Asp Tyr Val Met Asn 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  5

Ala Ile Asn Trp Asn Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Met Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  6

Asp Thr Val Val Ser Gly Asn Gly Tyr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  7

Asp Tyr Ala Met Ser 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  8

Ala Ile Ser Trp Asn Gly Ser Ser Thr Tyr Tyr Ala Glu Ser Met Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  9

Asp Leu Ile Gly Ser His Asp Tyr 
1               5               


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  10

Gly Asn Tyr Tyr Ala Trp Ser 
1               5           


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  11

Val Ile Ala Tyr Asp Gly Ser Thr Tyr Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  12

Gly Pro Gly Trp Tyr Ser Gly Ser Arg Asn Asp Tyr 
1               5                   10          


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  13

Met Asn Ser Ile Asp 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  14

Arg Ile Asp Pro Glu Asp Gly Gly Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  15

Val Asp Asp Tyr Tyr Leu Gly Tyr Asp Tyr 
1               5                   10  


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  16

Asn Tyr Val Ile Asp 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  17

Arg Ile Asp Pro Glu Asn Gly Gly Thr Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  18

Leu Glu Asp Tyr Glu Leu Ala Tyr Asp Tyr 
1               5                   10  


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  19

Thr Asn Tyr Tyr Tyr Trp Ser 
1               5           


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  20

Val Ile Ala Tyr Asp Gly Ser Thr Asp Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  21

Asp Val Arg Val Ile Ala Thr Gly Trp Ala Thr Ala Asn Ala Leu Asp 
1               5                   10                  15      


Ala 
    


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  22

Lys Ser Ser Gln Ser Val Leu Trp Arg Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  23

Trp Ala Ser Ile Arg Glu Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  24

Gln Gln Gly Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  25

Lys Ser Ser Gln Ser Val Leu Leu Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  26

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  27

Gln Gln Gly Val Ser Phe Pro Leu Thr 
1               5                   


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  28

Thr Gly Thr Asn Ser Asp Val Gly Tyr Gly Asn Tyr Val Ser 
1               5                   10                  


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  29

Asp Val Asn Arg Arg Ala Ser 
1               5           


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  30

Ala Ser Tyr Arg Ser Ala Asn Asn Ala Val 
1               5                   10  


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  31

Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly Asn Tyr Val Ser 
1               5                   10                  


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  32

Ala Val Ser Tyr Arg Ala Ser 
1               5           


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  33

Ala Ser Tyr Arg Ser Ser Asn Asn Ala Ala Val 
1               5                   10      


<210>  34
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  34

Ala Gly Thr Ser Ser Asp Ile Gly Asn Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  35

Glu Val Asn Lys Arg Pro Ser 
1               5           


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  36

Ala Ser Tyr Arg Ser Ser Asn Asn Val Val 
1               5                   10  


<210>  37
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  37

Ala Gly Thr Ser Ser Asp Ile Gly Asp Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  38

Asp Val Asn Lys Arg Ala Ser 
1               5           


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  39

Ala Ser Tyr Arg Ser Arg Asn Asp Tyr Ala 
1               5                   10  


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  40

Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly Asn Tyr Val Ser 
1               5                   10                  


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  41

Ala Val Ser Thr Arg Ala Ser 
1               5           


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  42

Ala Ser Tyr Arg Ser Ser Asn Asn Tyr Ala 
1               5                   10  


<210>  43
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  43

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ile Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ser Leu Gly Glu Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Gly Ile Lys Pro Asn Asn Gly Leu Ala Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Ile Thr Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Leu Thr Val Ser Ser 
        115             


<210>  44
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  44

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Ala Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110     


<210>  45
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  45

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Met Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Thr Ile Ser Trp Asn Asp Ile Asn Thr Tyr Tyr Ala Glu Ser Met 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Arg Asp Asn Tyr Tyr Gly Thr Ser Gly Glu Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  46
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  46

Gln Val Gln Leu Gln Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ala Ile Asn Trp Asn Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Tyr Ser Leu Gln Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Thr Val Val Ser Gly Asn Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  47
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  47

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Asn Gly Ser Ser Thr Tyr Tyr Ala Glu Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Ile Gly Ser His Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  48
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  48

Glu Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Met Thr Gly Asn 
            20                  25                  30          


Tyr Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Val Ile Ala Tyr Asp Gly Ser Thr Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Gln Leu Ser Ser Val Ser Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Pro Gly Trp Tyr Ser Gly Ser Arg Asn Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  49
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  49

Glu Val Gln Leu Val Gln Pro Gly Val Glu Leu Arg Asn Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Met Asn 
            20                  25                  30          


Ser Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Val Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Asp Tyr Tyr Leu Gly Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  50
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  50

Glu Val Gln Leu Val Gln Pro Gly Ala Glu Leu Arg Asn Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asn Gly Gly Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Val Glu Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Glu Asp Tyr Glu Leu Ala Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  51
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  51

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Thr Thr Asn 
            20                  25                  30          


Tyr Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Val Ile Ala Tyr Asp Gly Ser Thr Asp Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Val Arg Val Ile Ala Thr Gly Trp Ala Thr Ala Asn 
            100                 105                 110         


Ala Leu Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  52
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  52

Glu Ile Val Met Thr Gln Ser Pro Ser Ser Val Thr Ala Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Trp Arg 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Leu Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Ser Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Thr Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  53
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  53

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Thr Ala Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Leu Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Val Ser Phe Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Leu 
            100                 105                 110         


Lys 
    


<210>  54
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  54

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Met Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Asn Arg Arg Ala Ser Gly Ile Ala Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Gly Asp Tyr His Cys Ala Ser Tyr Arg Ser Ala 
                85                  90                  95      


Asn Asn Ala Val Phe Gly Gly Gly Thr His Leu Phe Val Leu 
            100                 105                 110 


<210>  55
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  55

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Ala Val Ser Tyr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asn Asn Ala Ala Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110     


<210>  56
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  56

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Leu Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Ile Gly Asn Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ser Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asn Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  57
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  57

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Leu Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Ile Gly Asp Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Asn Lys Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ser Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Arg 
                85                  90                  95      


Asn Asp Tyr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  58
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  58

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Leu Gly Lys 
1               5                   10                  15      


Thr Leu Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Val Ser Thr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asn Asn Tyr Ala Phe Gly Ala Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  59
<211>  383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  59
caggtgcagc tcgtggagtc gggcccaggc ctggtgaagc cctcgcagac actctccctc       60

acctgcgctg tctctggtgg ctccatcaca accaactatt actactggag ctggattcgc      120

cagtccccag ggaaggggct ggagtggatg ggagtcatag cttatgatgg cagcactgac      180

tacagcccat ccctcaagag ccgcacttcc atctccaggg acacgtccaa gaaccagttc      240

tccctgcagc tgagctctgt gacccctgag gacacggccg tgtattactg tgccagagat      300

gtaagggtaa tcgctacggg ttgggctact gccaatgctt tggacgcatg gggccagggg      360

accctggtca ctgtctcctc agc                                              383


<210>  60
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  60
gaggtccagc tggtgcagcc aggggttgaa ctgagaaacc ctggggcatc agtgaaggtc       60

tcctgcaagg cttctggata cattttcacc atgaactcaa tagactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaaga attgaccctg aagatggtgg cacaaagtat      180

gcacagaagt tccagggcag agtcaccttc actgcagaca cgtccaccag cacagcctac      240

gtggagctga acagtctgag atctgaggac acggccgtgt attactgtgc gagagtagat      300

gactattacc tagggtatga ctactggggc caggggaccc aggtcaccgt ctcctca         357


<210>  61
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  61
gaggtccagc tggtgcagcc aggggctgag ctgagaaacc ctggggcatc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc aactacgtca tagactgggt acgacaggcc      120

cctggacaag ggcttgagtg gatgggaaga attgaccctg aaaacggtgg cacgaggtat      180

gcacagaagt tccagggcag agtcaccttc actgcagaca cgtccaccag cacagcctac      240

gtggagttga gcaatctgag atctgaggac acggccgtgt attactgtgc aagactggaa      300

gactacgaat tggcttatga ctactggggc caggggaccc aggtcaccgt ctcttcag        358


<210>  62
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  62
caggtgcagc tcgtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cacttttgat gattatgcca tgagctgggt ccgacaggct      120

ccagggaagg ggctggagtg ggtctcagct attagctgga atggtagtag cacatactat      180

gcagaatcca tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat      240

ctgcaaatga acagtctgaa atctgaggac acggccgtgt attactgtgc aaaagatcta      300

ataggatccc atgactactg gggccagggg acccaggtca ccgtgtcctc a               351


<210>  63
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  63
cagttgcagc tggtggagtc tgggggaggc atggcgcagc ctggggggtc tctgaaactc       60

tcctgtgcag cctctggatt cactttcgat gattatgcca tgacctgggt ccgacaggct      120

ccagggaagg ggctggagtg gctctcaact attagctgga atgacattaa cacatactat      180

gcagaatcca tgaaggaccg attcaccatc tccagagaca acgccaagaa cacgctgtat      240

ctgcaaatga acagtctcga atctgaggac acggccgtgt attactgtgc aaaacgtagg      300

gataattact acgggacttc cggggagtat gactactggg gccaggggac ccaggtcacc      360

gtctcctca                                                              369


<210>  64
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  64
caggtgcagc tgcaggagtc ggggggagac ttggtgcagc cgggggggtc tctgagactc       60

tcctgtgcag cctctggatt cacttttgat gattatgtca tgaactgggt ccgacaggct      120

ccagggaagg ggctggagtg gatctcagct attaactgga atggtggtag cacatactat      180

gcagaatcca tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat      240

ctgcaaatgt acagtctgca atctgacgac acggccgtgt attactgtgt aaaagatacg      300

gtagtgtctg gtaatggcta ctggggccag gggacccagg tcaccgtgtc ctca            354


<210>  65
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  65
cagtctgtgt tgacgcagcc tccctccgtg tctgggtctc caggaaagac ggtcaccatc       60

tcctgtgcag gaaccagcag tgatgttggg tatggaaact atgtctcctg gtaccagcag      120

ctcccaggca cggcccccaa actcctgatc tttgcagtca gctatcgagc ctcagggatc      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ttttgaccat ctctgggctc      240

cagtccgagg acgaggctga ttattactgt gcctcatata gaagcagcaa caatgctgct      300

gtgttcggcg gagggaccca tctgaccgtc ctg                                   333


<210>  66
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  66
gaaattgtga tgacgcagtc tcccagctcc gtgactgcgt ctgcaggaga gaaggtcacc       60

atcaattgta agtccagcca gagtgtgtta tggcgctcca accagaaaaa ctacttagct      120

tggtaccagc agagacttgg acagtctcct aggctgctca tcagctgggc atccatccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtcca caacagattt cactcttacc      240

atcagcagct tccagcctga agacgcggca gtgtattact gccaacaggg ttatagtttt      300

ccatatacat tcggcagtgg gaccaggctg gaaatcaaa                             339


<210>  67
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  67
cagtctgccc tgactcagcc tccctccgtg tccggaactc tgggaaagac ggtcaccatc       60

tcttgcgctg gaaccagcag tgacattggg aactataact atgtctcctg gtatcaacag      120

ctcccaggaa cagcccccaa actcctgata tatgaggtca ataaacgacc ctcagggatc      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ccctgagcat ctctgggctc      240

cagtctgagg acgaggctga ttattactgt gcctcatata gaagcagcaa caatgttgtg      300

ttcggcggag ggaccaagct gaccgtcctc                                       330


<210>  68
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  68
cagtctgtgt tgacgcagcc tccctccgtg tccggaactc tgggaaagac ggtcaccatc       60

tcctgcgctg gaaccagcag tgacattggg gactataact atgtctcctg gtatcaacag      120

ctcccaggaa cggcccccaa actcctgata tatgacgtca ataaacgagc ctcagggatc      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ccctgagcat ctctgggctc      240

cagtctgagg acgaggctga ttattactgt gcctcatata gaagcaggaa cgattatgcc      300

ttcggcggag ggaccaagct gaccgtcctc                                       330


<210>  69
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  69
caggctgtgc tgactcagcc tccctccgtg tccggaactc tgggaaagac gctcaccatc       60

tcctgcgctg gaaccagcag tgatgttgga tacggaaact atgtctcctg gtaccaacag      120

ctcccaggca cggcccccaa actcctgatc tatgcagtca gcactcgagc ctcagggatc      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ccctgaccat ctctgggctc      240

cagtctgagg acgaggctga ttattactgt gcctcatata gaagcagcaa caattatgcg      300

ttcggcgcag ggaccaagct gaccgtcctc                                       330


<210>  70
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  70
gatattgtga tgacccagac tcccagctcc gtgactgcgt ctgcaggaga gaaggtcacc       60

atcaattgta agtccagcca gagtgtgtta ttgagctcca accagaaaaa ctacttagct      120

tggtaccagc agagacttgg acagtctcct aggctgctca tctactgggc atccacccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtcca caacagattt cactcttacc      240

atcagcagct tccagcctga agacgcggca gtgtattact gccagcaggg tgtaagtttt      300

ccacttacgt tcggccaggg gaccaaggtg gaactcaaa                             339


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  71

Ser Tyr Ala Met Ser 
1               5   


<210>  72
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  72

Gly Ile Tyr Lys Gly Gly Gly Pro Lys Tyr Ala Asn Ser Val Lys Gly 
1               5                   10                  15      


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  73

Ser Gly Tyr Gly Ser Ser Leu Gly Asp Phe Gly Ser 
1               5                   10          


<210>  74
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  74

Thr Gly Ser Ser Ser Asn Ile Gly Gly Gly Tyr Tyr Leu Ser 
1               5                   10                  


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  75

Ser Asn Ile Asn Arg Ala Ser 
1               5           


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  76

Ser Ser Trp Asp Asp Ser Val Ser Gly Pro Val 
1               5                   10      


<210>  77
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  77

Glu Leu Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Glu Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Lys Gly Gly Gly Pro Lys Tyr Ala Asn Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Ser Gly Tyr Gly Ser Ser Leu Gly Asp Phe Gly Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  78
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  78

Gln Ala Gly Leu Thr Gln Leu Ser Ser Met Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Thr Gly Ser Ser Ser Asn Ile Gly Gly Gly 
            20                  25                  30          


Tyr Tyr Leu Ser Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Ile Asn Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Thr Ser Gly Ile Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Asp Ser 
                85                  90                  95      


Val Ser Gly Pro Val Phe Gly Gly Gly Thr Ser Leu Thr Val Leu 
            100                 105                 110     


<210>  79
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  79
gagttgcagc tggtggagtc tgggggagcc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgtag agtctggatt caccttcagt agttatgcca tgagctgggt ccgccaggct      120

ccaggaaagg ggctcgagtg ggtctcaggt atttataaag gtggtggtcc aaaatatgca      180

aactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac gctgtatctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtttatt actgtgcaaa atcggggtac      300

ggtagtagcc ttggggactt tggttcctgg ggccagggga cccaggtcac cgtctcctcg      360


<210>  80
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  80
gaggtgcagg tgcaggagtc gggcccaggc ctggtgaagc cctcgcagac gctctccctc       60

acctgcactg tctctggtgg ctccatgaca ggcaactatt atgcttggag ctggatccgc      120

cagcccccag ggaaggggct ggagtggatg ggagtcatag cttatgatgg cagcacttac      180

tacagcccat ccctcaagag ccgcacttct atctccaggg acacgtccaa gaaccagttc      240

tccctgcagt tgagctctgt gagccctgag gacacggccg tgtattactg tgccagaggc      300

ccagggtggt atagtggtag caggaatgac tactggggcc aggggaccca ggtcaccgtc      360

tcctca                                                                 366


<210>  81
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  81
gcacaggcag ggctgactca gctgtcctcc atgtctggat ccccgggcca gacggtcacc       60

atcacctgca caggaagcag cagcaacatc gggggtggtt attatttgag ctggtaccaa      120

catctgccag gaacggcccc caaactcctg atctacagta acatcaatag ggcctcgggg      180

gtcccggacc gcttctctgg ctccacgtcg ggcatctcgg cctccctgac tatcactggg      240

ctccaggctg aggacgaggc tgactattac tgttcatcct gggatgacag cgtcagtggt      300

cctgtgttcg gcggagggac cagtctgacc gtcctc                                336


<210>  82
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  82
cagtctgccc tgactcagcc tccctccgtg tctgggtctc caggaaagac ggtcaccatc       60

tcctgtacag gaaccaacag tgatgttggg tacggaaact atgtctcctg gtaccagcag      120

ctcccaggaa tggcccccaa actcctgata tatgacgtca atagacgggc ctcagggatc      180

gctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ttctgggctc      240

cagtctgagg acgagggtga ttatcattgt gcctcatata gaagtgccaa caatgctgtg      300

ttcggcggag ggacccatct gttcgtcctg                                       330


<210>  83
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  83

Val Ile Ala Tyr Glu Gly Ser Thr Asp Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  84
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  84

Val Ile Ala Tyr Asp Ala Ser Thr Asp Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  85

Arg Ile Asp Pro Glu Glu Gly Gly Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  86

Lys Ser Ser Gln Ser Val Leu Phe Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  87

Gln Gln Gly Tyr Ser Phe Pro Tyr Ser 
1               5                   


<210>  88
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  88

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Thr Thr Asn 
            20                  25                  30          


Tyr Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Val Ile Ala Tyr Asp Gly Ser Thr Asp Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Val Arg Val Ile Ala Thr Gly Trp Ala Thr Ala Asn 
            100                 105                 110         


Ala Leu Asp Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  89
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  89

Asp Ile Val Met Thr Gln Thr Pro Thr Ser Val Thr Ala Ser Ala Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Leu Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Ser Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Arg 
    


<210>  90
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  90
caggtgcagc tcgtggagtc gggcccaggc ctggtgaagc cctcgcagac actctccctc       60

acctgcgctg tctctggtgg ctccatcaca accaactatt actactggag ctggattcgc      120

cagtccccag ggaaggggct ggagtggatg ggagtcatag cttatgatgg cagcactgac      180

tacagcccat ccctcaagag ccgcacttcc atctccaggg acacgtccaa gaaccagttc      240

tccctgcagc tgagctctgt gacccctgag gacacggccg tgtattactg tgccagagat      300

gtaagggtaa tcgctacggg ttgggctact gccaatgctt tggacgcatg gggccagggg      360

acccaggtca ccgtgtcctc a                                                381


<210>  91
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  91
gatattgtga tgacccagac tcccacctcc gtgactgcat ctgcaggaga caaggtcacc       60

atcaattgta agtccagcca gagtgtgtta ttcagctcca accagaaaaa ctacttagct      120

tggtaccagc agagacttgg acagtctcct aggctgctca tctactgggc ttccatccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtccg caacagattt cacgctaacc      240

atcagcaact tccagcctga agacgcggca gtatattact gccagcaggg ttatagtttt      300

ccatatagtt tcggcagtgg gaccaggctg gaaatcaga                             339


<210>  92
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Asn 
            20                  25                  30          


Tyr Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Val Ile Ala Tyr Glu Gly Ser Thr Asp Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Val Arg Val Ile Ala Thr Gly Trp Ala Thr Ala Asn 
            100                 105                 110         


Ala Leu Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  93
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  93

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Pro Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Ala Val Ser Tyr Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asn Asn Ala Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  94
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Thr Asn 
            20                  25                  30          


Tyr Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Val Ile Ala Tyr Glu Gly Ser Thr Asp Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Val Arg Val Ile Ala Thr Gly Trp Ala Thr Ala Asn 
            100                 105                 110         


Ala Leu Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  95
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  95

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Phe Ala Val Ser Tyr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asn Asn Ala Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  96
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  96

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Thr Asn 
            20                  25                  30          


Tyr Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Val Ile Ala Tyr Glu Gly Ser Thr Asp Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Gln Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Val Arg Val Ile Ala Thr Gly Trp Ala Thr Ala Asn 
            100                 105                 110         


Ala Leu Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  97
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  97

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Phe Ala Val Ser Tyr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asn Asn Ala Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  98
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  98

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Thr Asn 
            20                  25                  30          


Tyr Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Val Ile Ala Tyr Asp Ala Ser Thr Asp Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Gln Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Val Arg Val Ile Ala Thr Gly Trp Ala Thr Ala Asn 
            100                 105                 110         


Ala Leu Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  99
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  99

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Pro Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Phe Ala Val Ser Tyr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asn Asn Ala Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  100
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  100
caggtgcagc tcgtggagtc gggcccaggc ctggtgaagc cctcgcagac actctccctc       60

acctgcacag tctctggtgg ctccatcagc accaactatt actactggag ctggattcgc      120

cagtcgccag ggaaggggct ggagtggatt ggagtcatag cttatgaagg cagcactgac      180

tacagcccat ccctcaagag ccgcgtgacc atctccaggg acacgtccaa aaaccagttc      240

tccctgaaac tgagctctgt gaccgcggag gacacggccg tgtattactg tgccagagat      300

gtaagggtaa tcgctacggg ttgggctact gccaatgctt tggacgcatg gggccagggg      360

accctggtca ccgtgtcctc a                                                381


<210>  101
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  101
cagtctgcgt tgacgcagcc tccttccgtg tctgggtctc caggacaaag cgtcaccatc       60

tcctgtgcag gaaccagcag tgatgttggg tatggaaact atgtctcctg gtaccagcag      120

ccgccaggca cggcccccaa actcctgatc tttgcagtca gctatcgagc ctcaggggtt      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ctttgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgt gcctcatata gaagcagcaa caatgctgct      300

gtgttcggcg gagggaccaa actgaccgtc cta                                   333


<210>  102
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  102
caggtgcagc tccaggagtc gggcccaggc ctggtgaagc cctcgcagac actctccctc       60

acctgcgcag tctctggtgg ctccatcagc accaactatt actactggag ctggattcgc      120

cagcatccag ggaaggggct ggagtggatt ggagtcatag cttatgaagg cagcactgac      180

tacagcccat ccctcaagag ccgcgtgacc atctccgtgg acacgtccaa gaaccagttc      240

tccctgcaac tgagctctgt gaccccggag gacacggccg tgtattactg tgccagagat      300

gtaagggtaa tcgctacggg ttgggctact gccaatgctt tggacgcatg gggccagggg      360

accctggtca ccgtgtcctc a                                                381


<210>  103
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  103
cagtctgcgt tgacgcagcc tcgttccgtg tctgggtctc caggacaaag cgtcaccatc       60

tcctgtgcag gaaccagcag tgatgttggg tatggaaact atgtctcctg gtaccagcag      120

catccaggca cggcccccaa actcatgatc tttgcagtca gctatcgagc ctcagggatt      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ttttgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgt gcctcatata gaagcagcaa caatgctgct      300

gtgttcggcg gagggaccaa actgaccgtc cta                                   333


<210>  104
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  104
caggtgcagc tccaggagtc gggcccaggc ctggtgaagc cctcgcagac actctccctc       60

acctgcacag tctctggtgg ctccatcacc accaactatt actactggag ctggattcgc      120

cagtctccag ggaaggggct ggagtggatt ggagtcatag cttatgaagg cagcactgac      180

tacagcccat ccctcaagag ccgcgtgacc atctccaggg acacgtccaa gaaccagttc      240

tccctgcaac tgagctctgt gaccgcggag gacacggccg tgtattactg tgccagagat      300

gtaagggtaa tcgctacggg ttgggctact gccaatgctt tggacgcatg gggccagggg      360

accctggtca ccgtgtcctc a                                                381


<210>  105
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  105
cagtctgtgt tgacgcagcc tccttccgtg tctgggtctc caggacaaac cgtcaccatc       60

tcctgtgcag gaaccagcag tgatgttggg tatggaaact atgtctcctg gtaccagcag      120

ctgccaggca cggcccccaa actcatgatc tttgcagtca gctatcgagc ctcagggatt      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ctttgaccat ctctgggctc      240

cagtctgagg acgaggctga ttattactgt gcctcatata gaagcagcaa caatgctgct      300

gtgttcggcg gagggaccaa actgaccgtc cta                                   333


<210>  106
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  106
caggtgcagc tccaggagtc gggcccaggc ctggtgaagc cctcgcagac actctccctc       60

acctgcacag tctctggtgg ctccatcacc accaactatt actactggag ctggattcgc      120

cagtcgccag ggaaggggct ggagtggatt ggagtcatag cttatgatgc gagcactgat      180

tacagcccat ccctcaagag ccgcgtgacc atctccaggg acacgtccaa gaaccagttc      240

tccctgcaac tgagctctgt gaccgcggag gacacggccg tgtattactg tgccagagat      300

gtaagggtaa tcgctacggg ttgggctact gccaatgctt tggacgcatg gggccagggg      360

accctggtca ccgtgtcctc a                                                381


<210>  107
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  107
cagtctgtgt tgacgcagcc tccttccgtg tctgggtctc caggacaaac cgtcaccatc       60

tcctgtgcag gaaccagcag tgatgttggg tatggaaact atgtctcctg gtaccagcag      120

ccgccaggca cggcccccaa actcatgatc tttgcagtca gctatcgagc ctcagggatt      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ttttgaccat ctctgggctc      240

cagtctgagg acgaggctga ttattactgt gcctcatata gaagcagcaa caatgctgct      300

gtgttcggcg gagggaccaa actgaccgtc cta                                   333


<210>  108
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  108

Glu Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Met Asn 
            20                  25                  30          


Ser Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Glu Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Asp Tyr Tyr Leu Gly Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  109
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  109

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Ser Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  110
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  110

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Met Asn 
            20                  25                  30          


Ser Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Glu Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Asp Tyr Tyr Leu Gly Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  111
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  111

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Thr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Ser Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Arg 
    


<210>  112
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  112

Glu Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Met Asn 
            20                  25                  30          


Ser Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Glu Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Val Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Asp Tyr Tyr Leu Gly Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  113
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  113

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Glu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Ser Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Arg 
    


<210>  114
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  114

Gln Val Gln Leu Val Gln Pro Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Met Asn 
            20                  25                  30          


Ser Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Glu Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Asp Tyr Tyr Leu Gly Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  115
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  115

Asp Ile Val Met Thr Gln Ser Pro Thr Ser Val Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Arg Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Ser Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Arg 
    


<210>  116
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  116

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Met Asn 
            20                  25                  30          


Ser Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Glu Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Val Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Asp Tyr Tyr Leu Gly Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  117
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  117

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Ser Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  118
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  118

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Leu Arg Asn Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Met Asn 
            20                  25                  30          


Ser Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Glu Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Asp Tyr Tyr Leu Gly Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  119
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  119

Asp Ile Val Met Thr Gln Thr Pro Asp Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Thr Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Ser Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  120
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  120

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Met Asn 
            20                  25                  30          


Ser Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Glu Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Asp Tyr Tyr Leu Gly Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  121
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  121

Asp Ile Val Met Thr Gln Thr Pro Thr Ser Leu Ala Pro Ser Ala Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Ser Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  122
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  122
gaggtccagc tggtgcagcc aggggcggaa gtgaaaaaac ctggggcatc agtgaaggtc       60

tcctgcaagg cttctggata catcttcacc atgaactcaa tagactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaaga attgaccctg aagagggtgg cacaaagtat      180

gcacagaagt tccagggcag agtcaccatg actgcagaca cgtccaccag cacagcctac      240

atggagctga gcagtctgag atctgacgac acggccgtgt attactgtgc gagagtagat      300

gactattacc ttgggtatga ctactggggc caggggaccc aggtcaccgt ctcctca         357


<210>  123
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  123
gatattgtga tgacccagag ccccgattcc ttggcagcgt ctttaggaga acgtgtgacc       60

atcaattgta agtccagcca gagtgtgtta ttcagctcca accagaaaaa ctacttagct      120

tggtaccagc agagaccggg acagtctcct aagctgctca tctactgggc ttccatccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtccg gcacagattt cacgctaacc      240

atcagctctc ttcaggctga agacgtggca gtatattact gccagcaggg ttatagtttt      300

ccatatagtt tcggcagtgg gaccaggctc gagatcaaa                             339


<210>  124
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  124
caggtccagc tggtgcagtc tggggcggaa gtgaaaaaac ctggggcatc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc atgaactcaa tagactgggt gcgagaggcc      120

cctggacaag ggcttgagtg gatgggaaga attgaccctg aagagggtgg cacaaagtat      180

gcacagaagt tccagggcag agtcaccttc actcgagaca cgtccaccag cacagcctac      240

atggagctga gcagtctgag atctgacgac acggccgtgt attactgtgc gagagtagat      300

gactattacc ttgggtatga ctactggggc caggggaccc aggtcaccgt ctcctca         357


<210>  125
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  125
gatattgtga tgacccagag ccccgattcc ttgacagcgt ctttaggaga acgtgtgacc       60

atcaattgta agtccagcca gagtgtgtta ttcagctcca accagaaaaa ctacttagct      120

tggtaccagc agaaaccggg acagtctcct aagctgctca tctactgggc ttccatccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtccg gcacagattt cacgctaacc      240

atcagctctc ttcagcctga agacgtggca gtatattact gccagcaggg ttatagtttt      300

ccatatagtt tcggccaggg caccaggctc gagatcaga                             339


<210>  126
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  126
gaggtccagc tggtgcagcc aggggcggaa gtgaaaaaac ctggggcatc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc atgaactcaa tagactgggt gcgagaggcc      120

cctggacaag ggcttgagtg gatgggaaga attgaccctg aagagggtgg cacaaagtat      180

gcacagaagt tccagggcag agtcaccttc actcgagaca cgtccaccag cacagcctac      240

gtggagctga gcagtctgag atctgacgac acggccgtgt attactgtgc gagagtagat      300

gactattacc ttgggtatga ctactggggc caggggaccc tggtcaccgt ctcctca         357


<210>  127
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  127
gatattgtga tgacccagag ccccgattcc ttggcagtgt ctgaaggaga acgtgtgacc       60

atcaattgta agtccagcca gagtgtgtta ttcagctcca accagaaaaa ctacttagct      120

tggtaccagc agaaaccggg acagtctcct aggctgctca tctactgggc ttccatccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtccg ccacagattt cacgctaacc      240

atcagctctc ttcaggctga agacgtggca gtatattact gccagcaggg ttatagtttt      300

ccatatagtt tcggccaggg gaccaggctc gagatcaga                             339


<210>  128
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  128
caggtccagc tggtgcagcc aggggtggaa gtgaaaaaac ctggggcatc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc atgaactcaa tagactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaaga attgaccctg aagagggtgg cacaaagtat      180

gcacagaagt tccagggcag agtcaccttc actgcagaca cgtccaccag cacagcctac      240

atggagctga gcagtctgag atctgacgac acggccgtgt attactgtgc gagagtagat      300

gactattacc ttgggtatga ctactggggc caggggaccc aggtcaccgt ctcctca         357


<210>  129
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  129
gatattgtga tgacccagag ccccacctcc gtggcagtgt ctttaggaga acgtgcgacc       60

atcaattgta agtccagcca gagtgtgtta ttcagctcca accagaaaaa ctacttagct      120

tggtaccagc agaaaccggg acagcctcct aggctgctca tctactgggc ttccatccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtccg gcacagattt cacgctaacc      240

atcagctctc ttcagcctga agacgtggca gtatattact gccagcaggg ttatagtttt      300

ccatatagtt tcggccaggg gaccaggctc gagatcaga                             339


<210>  130
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  130
caggtccagc tggtgcagcc aggggcggaa gtgaaaaaac ctggggcatc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc atgaactcaa tagactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaaga attgaccctg aagagggtgg cacaaagtat      180

gcacagaagt tccagggcag agtcaccttc actgcagaca cgtccaccag cacagcctac      240

gtggagctga acagtctgag atctgaggac acggccgtgt attactgtgc gagagtagat      300

gactattacc ttgggtatga ctactggggc caggggaccc aggtcaccgt ctcctca         357


<210>  131
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  131
gatattgtga tgacccagag ccccgattcc ttggcagtgt ctttaggaga aaaggtgacc       60

atcaattgta agtccagcca gagtgtgtta ttcagctcca accagaaaaa ctacttagct      120

tggtaccagc agagaccggg acagcctcct aagctgctca tctactgggc ttccatccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtccg ccacagattt cacgctaacc      240

atcagctctc ttcagcctga agacgtggca gtatattact gccagcaggg ttatagtttt      300

ccatatagtt tcggccaggg gaccaggctc gagatcaaa                             339


<210>  132
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  132
gaggtccagc tggtgcagcc aggggcggaa ctgagaaacc ctggggcatc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc atgaactcaa tagactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaaga attgaccctg aagagggtgg cacaaagtat      180

gcacagaagt tccagggcag agtcaccatg actcgagaca cgtccaccag cacagcctac      240

atggagctga gcagtctgag atctgaggac acggccgtgt attactgtgc gagagtagat      300

gactattacc ttgggtatga ctactggggc caggggaccc aggtcaccgt ctcctca         357


<210>  133
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  133
gatattgtga tgacccagac ccccgattcc ttggcagtgt ctgcaggaga acgtgtgacc       60

atcaattgta agtccagcca gagtgtgtta ttcagctcca accagaaaaa ctacttagct      120

tggtaccagc agaaaccggg acagtctcct aagctgctca tctactgggc ttccatccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtccg gcacagattt tacgctaacc      240

atcagctctc ttcagcctga agacgtgaca gtatattact gccagcaggg ttatagtttt      300

ccatatagtt tcggccaggg gaccaggctc gagatcaaa                             339


<210>  134
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  134
caggtccagc tggtgcagcc aggggcggaa gtgaaaaaac ctggggcatc agtgaaggtc       60

tcctgcaagg cttctggata catcttcacc atgaactcaa tagactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaaga attgaccctg aagagggtgg cacaaagtat      180

gcacagaagt tccagggcag agtcaccatg actgcagaca cgtccaccag cacagcctac      240

atggagctga acagtctgag atctgaggac acggccgtgt attactgtgc gagagtagat      300

gactattacc ttgggtatga ctactggggc caggggaccc tggtcaccgt ctcctca         357


<210>  135
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  135
gatattgtga tgacccagac ccccacctcc ttggcaccgt ctgcaggaga acgtgcgacc       60

atcaattgta agtccagcca gagtgtgtta ttcagctcca accagaaaaa ctacttagct      120

tggtaccagc agaaaccggg acagcctcct aagctgctca tctactgggc ttccatccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtccg ccacagattt cacgctaacc      240

atcagctctc ttcagcctga agacgtggca gtatattact gccagcaggg ttatagtttt      300

ccatatagtt tcggcagtgg gaccaggctc gagatcaaa                             339


<210>  136
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  136

Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile Cys Leu 
1               5                   10                  15      


Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu Gly Gly 
            20                  25                  30          


Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg Asn Asn 
        35                  40                  45              


Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu Ser Cys 
    50                  55                  60                  


Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys Thr Val 
65                  70                  75                  80  


Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile Ser Asn 
                85                  90                  95      


Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp Pro 
            100                 105                 110     


<210>  137
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  137

Lys Ser Ser Gln Ser Val Leu Tyr Asn Pro Asn Gln Lys Ser Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  138
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  138

Lys Ser Ser Gln Ser Val Leu Tyr Thr Ser Asn His Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  139

Gln Gln Gly Trp Ser Phe Pro Tyr Ser 
1               5                   


<210>  140
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  140

Lys Ser Ser Gln Ser Val Leu Tyr Asn Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  141

Gln Gln Gly Trp Ser Phe Pro Tyr Thr 
1               5                   


<210>  142
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  142

Lys Ser Ser Gln Ser Val Leu Tyr Gly Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  143
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  143

Lys Ser Ser Gln Ser Val Leu Trp Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  144
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  144

Ala Gly Thr Ser Thr Asp Val Gly Tyr Gly Asn Tyr Val Ser 
1               5                   10                  


<210>  145
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  145

Ala Ser Tyr Arg Ser Ser Asn Lys Asn Ala Val 
1               5                   10      


<210>  146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  146

Ala Ser Tyr Arg Ile Thr Asn Arg His Ser Val 
1               5                   10      


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  147

Ala Ser Tyr Arg Arg Ser Thr Asn Val Gly Val 
1               5                   10      


<210>  148
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  148

Ala Ser Tyr Arg Thr Ser Asn Asn Val Ala Val 
1               5                   10      


<210>  149
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  149

Glu Ile Val Met Thr Gln Ser Pro Ser Ser Val Thr Ala Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Trp Arg 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Leu Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Ser Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Thr Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  150
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  150

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Thr Ala Ala Val Gly 
1               5                   10                  15      


Glu Lys Val Ala Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Asn 
            20                  25                  30          


Pro Asn Gln Lys Ser Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe Ala Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Ser Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Arg 
    


<210>  151
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  151

Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Thr Ala Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Thr 
            20                  25                  30          


Ser Asn His Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Leu Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Trp Ser Phe Pro Tyr Ser Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  152
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  152

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Thr Ala Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Asn 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Leu Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Trp Ser Phe Pro Tyr Thr Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  153
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  153

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Thr Ala Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Leu Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Trp Ser Phe Pro Tyr Thr Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  154
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  154

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Thr Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Asn 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Leu Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Trp Ser Phe Pro Tyr Thr Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  155
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  155

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Thr Ala Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Asn 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Leu Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Trp Ser Phe Pro Tyr Thr Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  156
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  156

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Thr Ala Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Val Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Ser Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Arg 
    


<210>  157
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  157

Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Thr Ala Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Trp Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Val Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Thr Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Phe Gln Pro Glu Asp Ala Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Tyr Ser Phe Pro Tyr Ser Phe Gly Ser Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Arg 
    


<210>  158
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  158

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Ala Val Ser Tyr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asn Asn Ala Ala Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110     


<210>  159
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  159

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Leu Gly Lys 
1               5                   10                  15      


Thr Leu Thr Ile Ser Cys Ala Gly Thr Ser Thr Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Ala Val Ser Tyr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asn Asn Ala Ala Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110     


<210>  160
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  160

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Leu Gly Lys 
1               5                   10                  15      


Thr Leu Thr Ile Ser Cys Ala Gly Thr Ser Thr Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Ala Val Ser Tyr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asn Asn Ala Ala Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110     


<210>  161
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  161

Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Leu Gly Lys 
1               5                   10                  15      


Thr Leu Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Val Ser Tyr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ser Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asn Lys Asn Ala Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110     


<210>  162
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  162

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Lys Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Val Ser Tyr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ile Thr 
                85                  90                  95      


Asn Arg His Ser Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110     


<210>  163
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  163

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Leu Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Lys Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Val Thr Tyr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Arg Ser 
                85                  90                  95      


Thr Asn Val Gly Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110     


<210>  164
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  164

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Leu Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Tyr Gly 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Lys Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Val Ser Tyr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr His Cys Ala Ser Tyr Arg Thr Ser 
                85                  90                  95      


Asn Asn Val Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  165
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  165
gaaattgtga tgacgcagtc tcccagctcc gtgactgcgt ctgcaggaga gaaggtcacc       60

atcaattgta agtccagcca gagtgtgtta tggcgctcca accagaaaaa ctacttagct      120

tggtaccagc agagacttgg acagtctcct aggctgctca tcagctgggc atccatccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtcca caacagattt cactcttacc      240

atcagcagct tccagcctga agacgcggca gtgtattact gccaacaggg ttatagtttt      300

ccatatacat tcggcagtgg gaccaggctg gaaatcaaa                             339


<210>  166
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  166
gatattgtga tgacccagac tcctagctcc gtgactgcgg ctgtaggaga gaaggtcgct       60

atcaactgta agtccagcca gagcgtgtta tataacccca accagaaaag ctacttagct      120

tggtaccaac agagacctgg acaatctcct aggctgctca tctactgggc atccacccga      180

gaatcggggg ttcctgatcg cttcagcggc agtgggtcca caacagattt cgctcttacc      240

atcagcagct tccagcctga agacgcggca gtgtattact gccagcaggg ttatagtttt      300

ccatatagtt tcggcagtgg gaccaggctg gaaatcaga                             339


<210>  167
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  167
gatgttgtga tgactcagtc tcccagctcc gtgactgcat ctgtaggaga gaaggtcact       60

atcaactgta agtccagcca gagtgtgtta tacacctcca accacaaaaa ctacttagct      120

tggtaccagc agagacttgg acagtctcct aggctgctca tctactgggc atccacccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtcca caacagattt cactctgacc      240

atcagcagct tccagcctga agacgcggca gtgtattact gccagcaggg atggagtttt      300

ccatatagtt tcggcagtgg gaccaggctg gaaatcaaa                             339


<210>  168
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  168
gatattgtga tgacccagac tcccagctcc gtgactgcgt ctgcaggaga gaaggtcacc       60

atcaattgta agtccagcca gagtgtatta tacaactcca accagaaaaa ctacttagct      120

tggtaccagc agagacttgg acagtctcct aggctgctca tctactgggc atccacccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtcca caacagattt cactctgacc      240

atcagcagct tccagcctga agacgcggca gtgtattact gccagcaggg atggagtttt      300

ccatatactt tcggcagtgg gaccaggctg gaaatcaaa                             339


<210>  169
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  169
gatatccagt tgacccagtc tcccagctcc gtgacagcgt ctgcaggaga gaaggtcacc       60

atcaattgta agtccagcca gagtgtgtta tacggctcca accagaaaaa ctacttagct      120

tggtaccagc agagacttgg acagtctcct aggctgctca tctactgggc atccacccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtcca caacagattt cactctgacc      240

atcagcagct tccagcctga agacgcggca gtgtattact gccagcaggg atggagtttt      300

ccatatactt tcggcagtgg gaccaggctg gaaatcaaa                             339


<210>  170
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  170
gacatccagt tgacccagtc tcccagctcc gtgactgtgt ctgtaggaga gaaggtcacc       60

atcaattgta agtccagcca gagtgtatta tacaactcca accagaaaaa ctacttagct      120

tggtaccagc agagacttgg acagtctcct aggctgctca tctactgggc atccacccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtcca caacagattt cactctgacc      240

atcagcagct tccagcctga agacgcggca gtgtattact gccagcaggg atggagtttt      300

ccatatactt tcggcagtgg gaccaggctg gaaatcaaa                             339


<210>  171
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  171
gacatccaga tgacccagtc tcccagctcc gtgactgcgt ctgcaggaga gaaggtcacc       60

atcaattgta agtccagcca gagtgtatta tacaactcca accagaaaaa ctacttagct      120

tggtaccagc agagacttgg acagtctcct aggctgctca tctactgggc atccacccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtcca caacagattt cactctgacc      240

atcagcagct tccagcctga agacgcggca gtgtattact gccagcaggg atggagtttt      300

ccatatactt tcggcagtgg gaccaggctg gaaatcaaa                             339


<210>  172
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  172
gatattgtga tgacccagac tcccgcctcc gtgactgcgt ctgcaggaga gaaggtcacc       60

atcaattgta agtccagcca gagtgtgtta ttcagctcca accagaaaaa ctacttagct      120

tggtaccagc agagagttgg acagtctcct aggctgctca tctactgggc atccacccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtcca caacagattt cactcttacc      240

atcagcaact tccagcctga agacgcggca gtgtattact gccagcaggg ttatagtttt      300

ccatatagtt tcggcagtgg gactaggctg gaaatcaga                             339


<210>  173
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  173
gatgttgtga tgactcagtc tcccagctcc gtgactgcgt ctgcaggaga gaaggtcacc       60

atcaattgta agtccagtca gagtgtgtta tggagctcca accagaaaaa ctacttagct      120

tggtaccagc agagagttgg acagtctcct aggctgctca tctactgggc atccacccga      180

gaatcggggg ttcctgatcg attcagcggc agtgggtcca caacagattt cactcttacc      240

atcagcaact tccagcctga agacgcggca gtgtattact gccagcaggg ttatagtttt      300

ccatatagtt tcggcagtgg gaccaggctg gaaatcaga                             339


<210>  174
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  174
cagtctgtgt tgacgcagcc tccctccgtg tctgggtctc caggaaagac ggtcaccatc       60

tcctgtgcag gaaccagcag tgatgttggg tatggaaact atgtctcctg gtaccagcag      120

ctcccaggca cggcccccaa actcctgatc tttgcagtca gctatcgagc ctcagggatc      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ttttgaccat ctctgggctc      240

cagtccgagg acgaggctga ttattactgt gcctcatata gaagcagcaa caatgctgct      300

gtgttcggcg gagggaccca tctgaccgtc ctg                                   333


<210>  175
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  175
gcacagtctg tgctgacgca gcctccctcc gtgtccggaa ctctgggcaa gacgctcacc       60

atctcctgcg ctggaaccag cactgatgtt ggatacggaa actatgtctc ctggtaccaa      120

cagctcccag gcacggcccc caaactcctg atctttgcag tcagctatcg agcctcaggg      180

atccctgatc gcttctctgg ctccaagtca ggcaacacgg cctttttgac catctctggg      240

ctccagtccg aggacgaggc tgattattac tgtgcctcat atagaagcag caacaatgct      300

gctgtgttcg gcggagggac ccatctgacc gtcctg                                336


<210>  176
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  176
cagtctgccc tgactcagcc tccctccgtg tccggaactc tgggcaagac gctcaccatc       60

tcctgcgctg gaaccagcac tgatgttgga tacggaaact atgtctcctg gtaccaacag      120

ctcccaggca cggcccccaa actcctgatc tttgcagtca gctatcgagc ctcagggatc      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ttttgaccat ctctgggctc      240

cagtccgagg acgaggctga ttattactgt gcctcatata gaagcagcaa caatgctgct      300

gtgttcggcg gagggaccca tctgaccgtc ctg                                   333


<210>  177
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  177
ctgcctgtgc tgactcagcc tccctccgtg tccggaactc tgggaaagac gctcaccatc       60

tcctgcgctg gaaccagcag tgatgttgga tacggaaact atgtctcctg gtaccaacag      120

ctcccaggca cggcccccaa actcctgatc tatgcagtca gctatcgagc ctcagggatc      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ccctgagcat ctctgggctc      240

cagtctgagg acgaggctga ttattactgt gcctcatata gaagcagcaa caaaaatgct      300

gtgttcggcg gagggaccca tctgaccgtc ctg                                   333


<210>  178
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  178
cagtctgccc tgactcagcc tccctccgtg tctgggtctc caggaaagac ggtcaccatc       60

tcctgtgcag gaaccagcag tgatgttgga tacggaaact atgtctcctg gtaccaaaag      120

ctcccaggca cagcccccaa actcctgatc tatgcagtca gctatcgagc ctcagggatc      180

cctgatcgct tctctggctc ccggtcaggc aacacggcct ccctgaccat ctctgggctc      240

cagtctgagg acgaggctga ttattactgt gcctcatata gaatcaccaa caggcacagc      300

gtgttcggcg gagggaccca tctgaccgtc ctg                                   333


<210>  179
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  179
cagtctgccc tgactcagcc tccctccgtg tctggaactc tgggaaagac ggtcaccatc       60

tcctgcgctg gaaccagcag tgatgttggg tatggaaact atgtctcctg gtaccaaaag      120

ctcccaggca cagcccccaa actcctgatc tatgcagtca cctatcgagc ctcagggatc      180

cctgatcgct tctctggctc caagtcgggc aacacggcct ccctgaccat ctctgggctc      240

cagtctgagg acgaggctga ttattactgt gcctcatata gaagaagtac taatgtgggg      300

gtgttcggcg gagggaccca tctgaccgtc ctg                                   333


<210>  180
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  180
caggctgtgc tgactcagcc tccctccgtg tccggaactc tgggaaagac ggtcaccatc       60

tcctgcgctg gaaccagcag tgatgttgga tacggaaact atgtctcctg gtaccaaaag      120

ctcccaggca cagcccccaa actcctgatc tatgcagtca gctatcgagc ctcagggatc      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ccctgaccat ctctgggctc      240

cagtctgagg acgaggctga ttatcactgt gcctcatata gaaccagcaa caatgtggct      300

gtgttcggcg gagggaccaa gctgaccgtc ctc                                   333


<210>  181
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  181

Val Asp Thr Tyr Tyr Asp Asp Gln Leu Ile Ser Cys Gly Ser Val Asn 
1               5                   10                  15      


Arg Gly Thr Cys Gln Arg His Val Phe Pro His Asn His Thr Ala Asp 
            20                  25                  30          


Ile Gln Ser Glu Val His Cys Ile Phe Ser Pro Gln Ile Glu Glu Pro 
        35                  40                  45              


Ser Gln Cys Pro Asp Cys Val Val Ser Ala Leu Gly Ala Lys Val Leu 
    50                  55                  60                  


Ser Ser Val Lys Asp Arg Phe Ile Asn Phe Phe Val Gly Asn Thr Ile 
65                  70                  75                  80  


Asn Ser Ser Tyr Phe Pro Asp His Pro Leu His Ser Ile Ser Val Arg 
                85                  90                  95      


Arg Leu Lys Glu Thr Lys 
            100         


<210>  182
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  182

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  183
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  183

Cys Pro Pro Cys Pro 
1               5   


<210>  184
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  184

Ala Pro Glu Leu Leu Gly Gly Pro 
1               5               


<210>  185
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  185

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  186
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  186

Cys Pro Arg Cys Pro 
1               5   


<210>  187
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  187

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
1               5                   10                  15  


<210>  188
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  188

Glu Ser Lys Tyr Gly Pro Pro 
1               5           


<210>  189
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  189

Cys Pro Ser Cys Pro 
1               5   


<210>  190
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  190

Ala Pro Glu Phe Leu Gly Gly Pro 
1               5               


<210>  191
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  191

Glu Arg Lys 
1           


<210>  192
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  192

Cys Cys Val Glu Cys Pro Pro Pro Cys Pro 
1               5                   10  


<210>  193
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  193

Ala Pro Pro Val Ala Gly Pro 
1               5           


<210>  194
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  194

Val Asp Thr Tyr Tyr Asp Asp Gln Leu Ile Ser Cys Gly Ser Val Asn 
1               5                   10                  15      


Arg Gly Thr Cys Gln Arg His Val Phe Pro His Asn His Thr Ala Asp 
            20                  25                  30          


Ile Gln Ser Glu Val His Cys Ile Phe Ser Pro Gln Ile Glu Glu Pro 
        35                  40                  45              


Ser Gln Cys Pro Asp Cys Val Val Ser Ala Leu Gly Ala Lys Val Leu 
    50                  55                  60                  


Ser Ser Val Lys Asp Arg Phe Ile Asn Phe Phe Val Gly Asn Thr Ile 
65                  70                  75                  80  


Asn Ser Ser Tyr Phe Pro Asp His Pro Leu His Ser Ile Ser Val Arg 
                85                  90                  95      


Arg Leu Lys Glu Thr Lys 
            100         


<210>  195
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is any amino acid, preferably T or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is any amino acid, preferably I

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any amino acid, preferably S or N

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is any amino acid, preferably W

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is any amino acid, preferably N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is any amino acid, preferably D or G

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is any amino acid, preferably I, G or S

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X8 is any amino acid, preferably N or S

<400>  195

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Tyr Tyr Ala Glu Ser Met Lys 
1               5                   10                  15      


<210>  196
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is any amino acid, preferably Y or D

<400>  196

Val Ile Ala Tyr Asp Gly Ser Thr Xaa Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  197
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is any amino acid, preferably D, N or E

<400>  197

Arg Ile Asp Pro Glu Xaa Gly Gly Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  198
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is any amino acid, preferably D or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is any amino acid, preferably A or V

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is any amino acid, preferably T, N or S

<400>  198

Xaa Asp Tyr Xaa Met Xaa 
1               5       


<210>  199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is any amino acid, preferably G or T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is any amino acid, preferably A or Y

<400>  199

Xaa Asn Tyr Tyr Xaa Trp Ser 
1               5           


<210>  200
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is any amino acid, preferably M or N

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is any amino acid, preferably N or Y

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any amino acid, preferably S or V

<400>  200

Xaa Xaa Xaa Ile Asp 
1               5   


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is any amino acid, preferably Y or W

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is any amino acid, preferably Y or L

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is any amino acid, preferably T or S

<400>  201

Gln Gln Gly Xaa Ser Phe Pro Xaa Xaa 
1               5                   


<210>  202
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is any amino acid, preferably S, I, R or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is any amino acid, preferably A, S, T or R

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is any amino acid, preferably N or T

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is any amino acid, preferably N, D, R or K

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is any amino acid, preferably A, V, Y, N or H

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is any amino acid, preferably V, A, S or G

<400>  202

Ala Ser Tyr Arg Xaa Xaa Xaa Xaa Xaa Xaa Val 
1               5                   10      


<210>  203
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is any amino acid, preferably I or T

<400>  203

Trp Ala Ser Xaa Arg Glu Ser 
1               5           


<210>  204
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is any amino acid, preferably D, A or E

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any amino acid, preferably N or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is any amino acid, preferably R, Y or K

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is any amino acid, preferably A, or P

<400>  204

Xaa Val Xaa Xaa Arg Xaa Ser 
1               5           


<210>  205
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is any amino acid, preferably W, L or F

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is any amino acid, preferably R or S

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is any amino acid, preferably S or P

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is any amino acid, preferably Q or H

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is any amino acid, preferably N or S

<400>  205

Lys Ser Ser Gln Ser Val Leu Xaa Xaa Xaa Asn Xaa Lys Xaa Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  206
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is any amino acid, preferably A or T

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is any amino acid, preferably T or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is any amino acid, preferably S or N

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is any amino acid, preferably S or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is any amino acid, preferably D or N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is any amino acid, preferably V or I

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is any amino acid, preferably Y, G, D or N

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is any amino acid, preferably G or Y

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is any amino acid, preferably N or Y

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is any amino acid, preferably V or L

<400>  206

Xaa Gly Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Tyr Xaa Ser 
1               5                   10                  


