
                                SEQUENCE LISTING

<110> MODIFIED VALENCENE SYNTHASE POLYPEPTIDES, ENCODING NUCLEIC ACID MOLECULES
      AND USES THEREOF

<120>  Allylix, Inc.
       Amick, Jean Davin  
       Park, Eunyoung
       Julien, Bryan
       Burlingame, Richard P.
  

<130> 33322.00203.WO01/203PC

<140>  Not Yet Assigned
<141>  Herewith

<150> 61/455,990
<151> 2010-10-29

<150> 61/573,745
<151> 2011-09-09

<160> 1007

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1647
<212> DNA
<213> Citrus sinensis

<220> 
<223> Citrus valencene synthase

<400> 1
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatca attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 2
<211> 548
<212> PRT
<213> Citrus sinensis

<220> 
<223> Citrus Valencene Synthase

<400> 2
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 3
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS V18

<400> 3
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 4
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS V19

<400> 4
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 5
<211> 547
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V75 and V76

<400> 5
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro
545         


<210> 6
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V1

<400> 6
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asp Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Tyr Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 7
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V2

<400> 7
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 8
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V3

<400> 8
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Val Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 9
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V4

<400> 9
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Cys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 10
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V5

<400> 10
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 11
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V6

<400> 11
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 12
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V7

<400> 12
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asp Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 13
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V8

<400> 13
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 14
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V9

<400> 14
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asp Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 15
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V10

<400> 15
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asp Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Val Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 16
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V12

<400> 16
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asp Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 17
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V13

<400> 17
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asp Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Ser Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 18
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V14

<400> 18
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asp Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 19
<211> 547
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V15

<400> 19
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Gly Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asp Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro
545         


<210> 20
<211> 547
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V16

<400> 20
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asp Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro
545         


<210> 21
<211> 547
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V17

<400> 21
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Arg Ile Asp Ser Thr Ser Asp His Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro
545         


<210> 22
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V20

<400> 22
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Ser
305                 310                 315                 320 
Ala Arg Trp Asn Ile Lys Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 23
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V21

<400> 23
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Gly Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Gly
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 24
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V22 and V23

<400> 24
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Met Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 25
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V24 and V33

<400> 25
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Gly
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 26
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V27 and V30

<400> 26
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 27
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V28

<400> 27
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Gly Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 28
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V31

<400> 28
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Asp Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 29
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V32

<400> 29
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Tyr Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 30
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V34

<400> 30
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser Leu Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 31
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V35 and V47

<400> 31
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 32
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V36

<400> 32
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Asp
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 33
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V40

<400> 33
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Val Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 34
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V41

<400> 34
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Gly Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Gly Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 35
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V42

<400> 35
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 36
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V43

<400> 36
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Asp Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 37
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V44

<400> 37
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 38
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V45

<400> 38
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Pro Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 39
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V46

<400> 39
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile His Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 40
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V48

<400> 40
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Val Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser Ala Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 41
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V49

<400> 41
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Ser Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 42
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V50

<400> 42
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Gly Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 43
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V51

<400> 43
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Leu Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 44
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V52

<400> 44
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Thr Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 45
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V53

<400> 45
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Leu Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 46
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V54

<400> 46
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Thr Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 47
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V55

<400> 47
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gly Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 48
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V56

<400> 48
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr His Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Ala Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 49
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V57

<400> 49
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Leu Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 50
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V58 and V59

<400> 50
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Tyr Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr His Pro Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 51
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V60

<400> 51
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Leu Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr His Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 52
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V61

<400> 52
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Leu Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Tyr Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Pro Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 53
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V62

<400> 53
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 54
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V63

<400> 54
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Leu Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 55
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V64 and V65

<400> 55
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr His Thr Glu Cys Thr Met Phe Ser Glu Ala Gly
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 56
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V66

<400> 56
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Leu Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 57
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V67

<400> 57
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 58
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V68

<400> 58
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Leu Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 59
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V69

<400> 59
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 60
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V70

<400> 60
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr His Thr Glu Cys Ser Leu Phe Ser Glu Ala Gly
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 61
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V71

<400> 61
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Leu Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 62
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V72

<400> 62
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Asp Lys Val Ile Gly Asp Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Gly Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Gly Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 63
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V73 and V74

<400> 63
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Leu Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 64
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V77

<400> 64
Met Arg Asp Lys Gly Thr Cys Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 65
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V78

<400> 65
Met Glu Gly Asn Ser Val Gln Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Leu Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 66
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V79

<400> 66
Met Lys Arg Val Gly Arg Ala Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 67
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V228

<400> 67
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 68
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V80 and V81

<400> 68
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Met Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 69
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V82 and V83

<400> 69
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asn Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 70
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V85

<400> 70
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Ser Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 71
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V86

<400> 71
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Phe Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 72
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V87, V88, V89 and V90

<400> 72
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Gly Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 73
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V91

<400> 73
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp His Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 74
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V93

<400> 74
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Glu Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 75
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V94, V95 and V96

<400> 75
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Ser Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 76
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V97

<400> 76
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Ile Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 77
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V99 and V100

<400> 77
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Pro Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 78
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V101

<400> 78
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Asp Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 79
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V102, V103 and V10

<400> 79
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Leu Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 80
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V105 and V106

<400> 80
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Asn Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 81
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V107

<400> 81
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Trp Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Lys Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 82
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V108

<400> 82
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Met Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 83
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V109

<400> 83
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr His Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 84
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V110 and V111

<400> 84
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Cys Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 85
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V112

<400> 85
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Trp Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 86
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V113

<400> 86
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Ala Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 87
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V114 and V115

<400> 87
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Gly Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 88
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V117

<400> 88
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Trp Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 89
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V118

<400> 89
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu His Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 90
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V119 and V120

<400> 90
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Lys Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 91
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V121, V122 and V123

<400> 91
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ala Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 92
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V124 and V125

<400> 92
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 93
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V126

<400> 93
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Trp Gln Phe Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 94
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V127

<400> 94
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ala Pro Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 95
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V128

<400> 95
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Leu Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 96
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V129

<400> 96
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Leu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 97
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V131

<400> 97
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Leu Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 98
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V135

<400> 98
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Tyr Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 99
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V137

<400> 99
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Leu Pro Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 100
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V138, V139 and V140

<400> 100
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Ser Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 101
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V141 and V142

<400> 101
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Ala Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 102
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V143

<400> 102
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Ile Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 103
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V144, V145 and V178

<400> 103
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Arg Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 104
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V146

<400> 104
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Tyr Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 105
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V147 and V148

<400> 105
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Leu Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 106
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V149

<400> 106
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gly Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 107
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V150

<400> 107
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gly Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Ser Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 108
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V151

<400> 108
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Ala Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Ser Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 109
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V152

<400> 109
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Trp Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 110
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V153 and V154

<400> 110
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Pro Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 111
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V155

<400> 111
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Glu Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 112
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V156

<400> 112
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Thr Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala His Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 113
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V157

<400> 113
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Gly Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 114
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V158 and V159

<400> 114
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Pro Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 115
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V160

<400> 115
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Gly Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 116
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V161

<400> 116
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Val Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 117
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V162

<220> 
<221> VARIANT        
<222> 301
<223> Xaa = Asp or Glu

<220> 
<221> VARIANT        
<222> 358
<223> Xaa = Ile, Thr, Lys or Arg

<220> 
<221> VARIANT        
<222> 378
<223> Xaa = Phe, Leu, Ile or Val

<400> 117
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Gly Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Xaa Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Xaa Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Xaa Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 118
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V163 and V164

<400> 118
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Arg Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 119
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V165 and V166

<400> 119
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Asp Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 120
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V167

<400> 120
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Glu Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 121
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V168

<400> 121
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Asn Ser Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 122
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V169

<400> 122
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr His Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 123
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V170

<400> 123
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Lys Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 124
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V171

<400> 124
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ile Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 125
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V172

<220> 
<221> VARIANT        
<222> 342
<223> Xaa = L, S, W, P, Q, R, M, T, K, V, A, E or G

<400> 125
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Trp Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Xaa Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 126
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V173

<400> 126
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Thr Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 127
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V174

<400> 127
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Ala Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Ala Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Ala Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Ala Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Ala Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Ala Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Ala Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Met Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Arg Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 128
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS V18

<400> 128
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 129
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS V19

<400> 129
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 130
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V75 and V76

<400> 130
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 131
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V1

<400> 131
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaagaaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgctga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatcg attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaggcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctata aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 132
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V2

<400> 132
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatca attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acagattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 133
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V3

<400> 133
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgctac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatca attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgtttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacatttgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagagca aattgcatct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 134
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V4

<400> 134
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatca attcaacaag tgatcattta 660
tgcaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctgggag accacgttcc attttga                                     1647

<210> 135
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V5

<400> 135
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatca attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agatctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagta 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 136
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V6

<400> 136
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcccgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggttgc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtatattatg tccatgatca attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acacttttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 137
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V7

<400> 137
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtga tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatca attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 138
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V8

<400> 138
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatca attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagatt acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagattcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 139
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V9

<400> 139
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaagaaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgctga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatcg attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acagattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 140
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V10

<400> 140
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaagaaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgctga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatcg attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaaggtgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgtttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acagatttgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacccat tcttacctaa ttaaagagca aattgcatct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 141
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V12

<400> 141
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaagaaga atgataacag atgctgaaga taagcctatt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgctga acagataaat catgctttat accgtcccct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatcg attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atacttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acagattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 142
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V13

<400> 142
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaagaaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgctga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatcg attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acagattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccagtaac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 143
<211> 1648
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V14

<400> 143
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaagaaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgctga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatcg attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaagaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg accaaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acagattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttgaa                                    1648

<210> 144
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V15

<400> 144
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaagcac tgaaagaaga ggtaagaaga atgataacag atgctgaaga taagcctggt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactactact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgctga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatcg attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acagattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 145
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V16

<400> 145
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaagaaga atgataacag atgctgaaga taagcctatt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgctga acagataaat catgctttat accgtcccct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatcg attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagcta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atacttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acagattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccggtaac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 146
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V17

<400> 146
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaagaaga atgataacag atgctgaaga taagcctatt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgctga acagataaat catgctttat accgtcccct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccaggatcg attcaacaag tgatcattta 660
gtcaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagcta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atacttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acagattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccggtaac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 147
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V20

<400> 147
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagcttcg 960
gctcgttgga acattaaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 148
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V21

<400> 148
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagagga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctggt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 149
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V22

<400> 149
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctatgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 150
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V24

<400> 150
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctggc 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 151
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V25

<400> 151
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttgggag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 152
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V26

<400> 152
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagact tgttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 153
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V27

<400> 153
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 154
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V28

<400> 154
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaagg agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 155
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V29

<400> 155
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctctgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 156
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V30

<400> 156
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 157
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V31

<400> 157
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattgac aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 158
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V32

<400> 158
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtcctacatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 159
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V33

<400> 159
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctggg 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 160
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V34

<400> 160
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctctt 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 161
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V35

<400> 161
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 162
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V36

<400> 162
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgat 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 163
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V37

<400> 163
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 164
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V38

<400> 164
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt cgttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 165
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V40

<400> 165
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agttgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 166
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V41

<400> 166
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattggcaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aaggattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 167
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V39

<400> 167
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgac 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 168
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V23

<400> 168
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctatgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 169
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V42

<400> 169
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 170
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V43

<400> 170
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgactatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 171
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V44

<400> 171
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgcgatt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 172
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V45

<400> 172
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg cccgaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 173
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V46

<400> 173
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcac aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 174
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V47

<400> 174
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttctc agaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 175
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V48

<400> 175
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttggtgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctgcc 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 176
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V49

<400> 176
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccatcttacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 177
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V50

<400> 177
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa ggggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 178
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V51

<400> 178
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattctt ggaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 179
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V52

<400> 179
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg accgaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 180
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V53

<400> 180
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccactgtacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 181
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V54

<400> 181
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattga cgttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 182
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V55

<400> 182
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattggt aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 183
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V56

<400> 183
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactcac gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgcaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 184
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V57

<400> 184
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca tcttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgct ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 185
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V58 and V59

<400> 185
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtcctacatt 900
gatgatacct acgatgctta cggtactcac cccgaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 186
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V60

<400> 186
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcactgtacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactcac gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 187
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V61

<400> 187
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcactgtacg cttttggtag aaaaatcatg actaaattga actacatttt gtcctacatt 900
gatgatacct acgatgctta cggtactttg cccgaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 188
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V62

<400> 188
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 189
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V63

<400> 189
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt cgctgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgcgatt aatctacaga 1020
actttgttgg atacattctt ggaaatagaa gaggatatgg ctaaacaacg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 190
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V64

<400> 190
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactcac accgaatgca cgatgttcag tgaagctggc 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 191
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V65

<400> 191
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactcac accgaatgca cgatgttcag tgaagctggg 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 192
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V66

<400> 192
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattctt ggaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 193
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V67

<400> 193
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 194
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V68

<400> 194
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgcgatt aatctacaga 1020
actttgttgg atacattctt ggaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 195
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V69

<400> 195
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 196
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V70

<400> 196
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactcac accgaatgct cgctgttcag tgaagctggc 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 197
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V71

<400> 197
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgcgatt aatctacaga 1020
actttgttgg atacattctt ggaaatagaa gaggatatgg ctaaacaacg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 198
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V72

<400> 198
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattgat aaggttattg gtgactatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattggcaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aaggattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 199
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V73 and V74

<400> 199
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgcgaat aatctacaga 1020
actttgttgg atacattctt ggaaatagaa gaggatatgg ctaaacaacg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 200
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V77

<400> 200
atgcgggaca agggtacgtg tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 201
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V78

<400> 201
atggagggaa atagtgtcca aagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtac tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 202
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V79

<400> 202
atgaagcgcg tagggagggc gagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 203
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V228

<400> 203
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 204
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V80 and V81

<400> 204
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttgga tgttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 205
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V82 and V83

<400> 205
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttgga acttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 206
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V85

<400> 206
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggt ccttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 207
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V86

<400> 207
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggt tcttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 208
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V87 and V88

<400> 208
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg gattgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 209
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V91

<400> 209
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggc acttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 210
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V93

<400> 210
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg agttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 211
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V89

<400> 211
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg gcttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 212
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V90

<400> 212
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg gtttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 213
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V94

<400> 213
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattctgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 214
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V97

<400> 214
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatattgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 215
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V99

<400> 215
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatccggaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattaa actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 216
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V101

<400> 216
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatgacgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 217
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V102

<400> 217
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatcttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 218
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V105

<400> 218
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttataatgaa 840
ccacaatacg cttttggcag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 219
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V107

<400> 219
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
tggcaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaataaaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 220
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V108

<400> 220
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatatggaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 221
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V109

<400> 221
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatcacgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 222
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V110 and V111

<400> 222
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattgtgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 223
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V95

<400> 223
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattccgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 224
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V112

<400> 224
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
tggcaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 225
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V113

<400> 225
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatgctgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 226
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V103 and V104

<400> 226
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatttggaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 227
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V106

<400> 227
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttataatgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 228
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V114

<400> 228
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatggggaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 229
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V100

<400> 229
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatccggaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattaa actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 230
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V115

<400> 230
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatggagaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 231
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V116

<400> 231
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatttcgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 232
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V96

<400> 232
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattccgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 233
<211> 1648
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V117

<400> 233
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttatttggga 840
accacaatac gcttttggta gaaaaatcat gactaaattg aactacattt tgtccattat 900
tgatgatacc tacgatgctt acggtacttt ggaagaattg tctttgttca ccgaagctgt 960
tgctcgttgg aacattgaag ctgttgacat gttgccagat tatatgaagt taatctacag 1020
aactttgttg gatacattca acgaaataga agaggatatg gctaaacaag gtagatctca 1080
ttgtgtaaga tacgctaaag aagaaattca aaaggttatt ggtgcttatt acgttcaagc 1140
taagtggttt tctgaaggtt atgtccctac tattgaagaa tacatgccaa ttgctttgac 1200
ttcttgcgct tacagatttg ttattaccaa ttcttttttg ggtatgggtg atttcgctac 1260
aaaggaagta ttcgaatgga tttctggtaa tccaaaagtt gttaaatctg cttctgttat 1320
ttgtagattg atggacgata tgcaaggaca cgaatttgaa caaaaaagag gtcacgttgc 1380
atctgcaatt gaatgctata ctaaacaaca tggtgtttcc aaggaagagg ctatcaagat 1440
gttcgaggaa gaggttgcta acgcttggaa ggatatcaat gaagaattaa tgatgaaacc 1500
accagttgtt gctagaccat tgttaggtac tattttgaat ttggctagag ctatcgattt 1560
tatctataaa gaagatgacg gttacactca ttcttatttg attaaggaac aaatagcatc 1620
tgttttgggt gatcatgttc cattttaa                                    1648

<210> 234
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V118

<400> 234
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
catcaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 235
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V119

<400> 235
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
aaacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 236
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V121

<400> 236
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
gcgcaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 237
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V124

<400> 237
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 238
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V126

<400> 238
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
tggcaattcg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 239
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V127

<400> 239
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
gccccatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 240
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V128

<400> 240
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccccaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgctcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 241
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V129

<400> 241
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttctg 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 242
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V122 and V123

<400> 242
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
gcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 243
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V131

<400> 243
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ctgcaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 244
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V135

<400> 244
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
tatcaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 245
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V120

<400> 245
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
aagcaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 246
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant 132

<400> 246
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
cttcaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 247
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V133

<400> 247
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccgcaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 248
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V134

<400> 248
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccccaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 249
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V137

<400> 249
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ctcccatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 250
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V125

<400> 250
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatacgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 251
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V138 and V139

<400> 251
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccatcatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 252
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V141

<400> 252
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccagcctacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 253
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V143

<400> 253
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccaatctacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 254
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V144

<400> 254
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacgatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 255
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V146

<400> 255
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccatactacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 256
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V142

<400> 256
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccagcatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 257
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V147

<400> 257
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccactttacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 258
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V140

<400> 258
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccatcttacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 259
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V148

<400> 259
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccactgtacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 260
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V145

<400> 260
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacgttacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 261
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V149

<400> 261
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccagggtacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 262
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V150

<400> 262
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccagggtacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga gcattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 263
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V151

<400> 263
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccagcgtacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcag cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 264
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V152

<400> 264
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccatggtacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 265
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V153

<400> 265
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccaccgtacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 266
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V154

<400> 266
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccaccttacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 267
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V155

<400> 267
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccagagtacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 268
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V156

<400> 268
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaataca cgtttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctca cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 269
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V157

<400> 269
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg gctttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 270
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V158 and V159

<400> 270
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacc catttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 271
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V177

<400> 271
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cgtttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 272
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V160

<400> 272
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg gatttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 273
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V161

<400> 273
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg tctttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 274
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V178

<400> 274
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacggtacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 275
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V162

<220> 
<221> variation      
<222> 903, 1073, 1132, 1158
<223> n = a, c, t or g

<400> 275
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg gttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gangatacct acgatgcgta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tanatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cnttcaagct 1140
aagtggtttt ctgaaggnta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 276
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V163

<400> 276
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacc gttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 277
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V165 and V166

<400> 277
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg attttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 278
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V167

<400> 278
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg agtttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 279
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V168

<400> 279
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaaaact cctttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 280
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V164

<400> 280
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaataca ggtttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 281
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V169

<400> 281
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacc actttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 282
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V170

<400> 282
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaataca agtttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 283
<211> 1646
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V171

<400> 283
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaataca tcttggtaga aaaatcatga ctaaattgaa ctacattttg tccattattg 900
atgataccta cgatgcttac ggtactttgg aagaattgtc tttgttcacc gaagctgttg 960
ctcgttggaa cattgaagct gttgacatgt tgccagatta tatgaagtta atctacagaa 1020
ctttgttgga tacattcaac gaaatagaag aggatatggc taaacaaggt agatctcatt 1080
gtgtaagata cgctaaagaa gaaattcaaa aggttattgg tgcttattac gttcaagcta 1140
agtggttttc tgaaggttat gtccctacta ttgaagaata catgccaatt gctttgactt 1200
cttgcgctta cagatttgtt attaccaatt cttttttggg tatgggtgat ttcgctacaa 1260
aggaagtatt cgaatggatt tctggtaatc caaaagttgt taaatctgct tctgttattt 1320
gtagattgat ggacgatatg caaggacacg aatttgaaca aaaaagaggt cacgttgcat 1380
ctgcaattga atgctatact aaacaacatg gtgtttccaa ggaagaggct atcaagatgt 1440
tcgaggaaga ggttgctaac gcttggaagg atatcaatga agaattaatg atgaaaccac 1500
cagttgttgc tagaccattg ttaggtacta ttttgaattt ggctagagct atcgatttta 1560
tctataaaga agatgacggt tacactcatt cttatttgat taaggaacaa atagcatctg 1620
ttttgggtga tcatgttcca ttttaa                                      1646

<210> 284
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V172

<220> 
<221> variation      
<222> (1024)...(1025)
<223> n = a, c, g or t

<400> 284
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatact ggtttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actnngttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 285
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V173

<400> 285
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaataca cctttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 286
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V175

<400> 286
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg catttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 287
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V174

<400> 287
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaataca tgtttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgtcgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 288
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V176

<400> 288
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgg ctggtgcatc agattttaag actgttgatc atacagctac agctgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tgctccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca agctttgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aagcttttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttggctt cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tgggctgatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cctttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 289
<211> 548
<212> PRT
<213> Citrus sinensis

<220> 
<223> Citrus valencene synthase Genbank Accession No.
      AAQ04608

<400> 289
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Gly Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Cys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 290
<211> 548
<212> PRT
<213> Citrus x paradisi

<220> 
<223> Citrus valencene synthase

<400> 290
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Leu Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Pro His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 291
<211> 548
<212> PRT
<213> Citrus x paradisi

<220> 
<223> Citrus valencene synthase Genbank Accession No.
      AAM00426

<400> 291
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Leu Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Pro His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asp Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 292
<211> 1647
<212> DNA
<213> Citrus sinensis

<220> 
<223> Citrus valencene synthase Genbank Accession No.
      AF441124

<400> 292
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaataggag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcggttg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatca attcaacaag tgatcattta 660
tgcaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 293
<211> 1647
<212> DNA
<213> Citrus x paradisi

<220> 
<223> Citrus valencene synthase

<400> 293
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaatact aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatca attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagccgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 294
<211> 1877
<212> DNA
<213> Citrus x paradisi

<220> 
<223> Citrus valencene synthase Genbank Accession No.
      AF411120

<400> 294
aatacaaatt ataattccac agaaatatca aaattctgcg gcacccgttt gtctgacaca 60
aaaatgtcgt ctggagaaac atttcgtcct actgcagatt tccatcctag tttatggaga 120
aaccatttcc tcaaaggtgc ttctgatttc aagacagttg atcatactgc aactcaagaa 180
cgacacgagg cactgaaaga agaggtaagg agaatgataa cagatgctga agataagcct 240
gttcagaagt tacgcttgat tgatgaagta caacgcctgg gggtggctta tcactttgag 300
aaagaaatag aagatgcaat actaaaatta tgtccaatct atattgacag taatagagct 360
gatctccaca ccgtttccct tcattttcga ttgcttaggc agcaaggaat caagatttca 420
tgtgatgtgt ttgagaagtt caaagatgat gagggtagat tcaagtcatc gttgataaac 480
gatgttcaag ggatgttaag tttgtacgag gcagcataca tggcagttcg cggagaacat 540
atattagatg aagccattgc tttcactacc actcacctga agtcattggt agctcaggat 600
catgtaaccc ctaagcttgc ggaacagata aatcatgctt tataccgtcc tcttcgtaaa 660
accctaccaa gattagaggc gaggtatttt atgtccatga tcaattcaac aagtgatcat 720
ttatacaata aaactctgct gaattttgca aagttagatt ttaacatatt gctagagccg 780
cacaaggagg aactcaatga attaacaaag tggtggaaag atttagactt cactacaaaa 840
ctaccttatg caagagacag attagtggag ttatattttt gggatttagg gacatacttc 900
gagcctcaat atgcatttgg gagaaagata atgacccaat taaattacat attatccatc 960
atagatgata cttatgatgc gtatggtaca cttgaagaac tcagcctctt tactgaagca 1020
gttcaaagat ggaatattga ggccgtagat atgcttccag aatacatgaa attgatttac 1080
aggacactct tagatgcttt taatgaaatt gaggaagata tggccaagca aggaagatca 1140
cactgcgtac gttatgcaaa agaggagaat caaaaagtaa ttggagcata ctctgttcaa 1200
gccaaatggt tcagtgaagg ttacgttcca acaattgagg agtatatgcc tattgcacta 1260
acaagttgtg cttacacatt cgtcataaca aattccttcc ttggcatggg tgattttgca 1320
actaaagagg tttttgaatg gatctccaat aaccctaagg ttgtaaaagc agcatcagtt 1380
atctgcagac tcatggatga catgcaaggt catgagtttg agcagaagag aggacatgtt 1440
gcgtcagcta ttgaatgtta cacgaagcag catggtgtct ctaaggaaga ggcaattaaa 1500
atgtttgaag aagaagttgc aaatgcatgg aaagatattg acgaggagtt gatgatgaag 1560
ccaaccgtcg ttgcccgacc actgctcggg acgattctta atcttgctcg tgcaattgat 1620
tttatttaca aagaggacga cggctatacg cattcttacc taattaaaga tcaaattgct 1680
tctgtgctag gagaccacgt tccattttga cgactagttc tatacttcta ttaataatat 1740
tttcagttcc ttggtttgtg tttaaaggaa atacggtgta tcgtattggt ctgtactaat 1800
aaatatttta tatttttatt gttacttaaa gattttccct tcgaataaaa aaataaactc 1860
taatataaaa aaaaaaa                                                1877

<210> 295
<211> 548
<212> PRT
<213> Nicotiana tabacum

<220> 
<223> Tobacco 5-epi-aristolochene synthase

<400> 295
Met Ala Ser Ala Ala Val Ala Asn Tyr Glu Glu Glu Ile Val Arg Pro
 1               5                  10                  15      
Val Ala Asp Phe Ser Pro Ser Leu Trp Gly Asp Gln Phe Leu Ser Phe
            20                  25                  30          
Ser Ile Lys Asn Gln Val Ala Glu Lys Tyr Ala Lys Glu Ile Glu Ala
        35                  40                  45              
Leu Lys Glu Gln Thr Arg Asn Met Leu Leu Ala Thr Gly Met Lys Leu
    50                  55                  60                  
Ala Asp Thr Leu Asn Leu Ile Asp Thr Ile Glu Arg Leu Gly Ile Ser
65                  70                  75                  80  
Tyr His Phe Glu Lys Glu Ile Asp Asp Ile Leu Asp Gln Ile Tyr Asn
                85                  90                  95      
Gln Asn Ser Asn Cys Asn Asp Leu Cys Thr Ser Ala Leu Gln Phe Arg
            100                 105                 110         
Leu Leu Arg Gln His Gly Phe Asn Ile Ser Pro Glu Ile Phe Ser Lys
        115                 120                 125             
Phe Gln Asp Glu Asn Gly Lys Phe Lys Glu Ser Leu Ala Ser Asp Val
    130                 135                 140                 
Leu Gly Leu Leu Asn Leu Tyr Glu Ala Ser His Val Arg Thr His Ala
145                 150                 155                 160 
Asp Asp Ile Leu Glu Asp Ala Leu Ala Phe Ser Thr Ile His Leu Glu
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Arg Glu Gln Val Thr His
            180                 185                 190         
Ala Leu Glu Gln Cys Leu His Lys Gly Val Pro Arg Val Glu Thr Arg
        195                 200                 205             
Phe Phe Ile Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Asn Val
    210                 215                 220                 
Leu Leu Arg Phe Ala Lys Leu Asp Phe Asn Leu Leu Gln Met Leu His
225                 230                 235                 240 
Lys Gln Glu Leu Ala Gln Val Ser Arg Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Val Thr Thr Leu Pro Tyr Ala Arg Asp Arg Val Val Glu Cys Tyr Phe
            260                 265                 270         
Trp Ala Leu Gly Val Tyr Phe Glu Pro Gln Tyr Ser Gln Ala Arg Val
        275                 280                 285             
Met Leu Val Lys Thr Ile Ser Met Ile Ser Ile Val Asp Asp Thr Phe
    290                 295                 300                 
Asp Ala Tyr Gly Thr Val Lys Glu Leu Glu Ala Tyr Thr Asp Ala Ile
305                 310                 315                 320 
Gln Arg Trp Asp Ile Asn Glu Ile Asp Arg Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Ile Ser Tyr Lys Ala Ile Leu Asp Leu Tyr Lys Asp Tyr Glu Lys Glu
            340                 345                 350         
Leu Ser Ser Ala Gly Arg Ser His Ile Val Cys His Ala Ile Glu Arg
        355                 360                 365             
Met Lys Glu Val Val Arg Asn Tyr Asn Val Glu Ser Thr Trp Phe Ile
    370                 375                 380                 
Glu Gly Tyr Thr Pro Pro Val Ser Glu Tyr Leu Ser Asn Ala Leu Ala
385                 390                 395                 400 
Thr Thr Thr Tyr Tyr Tyr Leu Ala Thr Thr Ser Tyr Leu Gly Met Lys
                405                 410                 415     
Ser Ala Thr Glu Gln Asp Phe Glu Trp Leu Ser Lys Asn Pro Lys Ile
            420                 425                 430         
Leu Glu Ala Ser Val Ile Ile Cys Arg Val Ile Asp Asp Thr Ala Thr
        435                 440                 445             
Tyr Glu Val Glu Lys Ser Arg Gly Gln Ile Ala Thr Gly Ile Glu Cys
    450                 455                 460                 
Cys Met Arg Asp Tyr Gly Ile Ser Thr Lys Glu Ala Met Ala Lys Phe
465                 470                 475                 480 
Gln Asn Met Ala Glu Thr Ala Trp Lys Asp Ile Asn Glu Gly Leu Leu
                485                 490                 495     
Arg Pro Thr Pro Val Ser Thr Glu Phe Leu Thr Pro Ile Leu Asn Leu
            500                 505                 510         
Ala Arg Ile Val Glu Val Thr Tyr Ile His Asn Leu Asp Gly Tyr Thr
        515                 520                 525             
His Pro Glu Lys Val Leu Lys Pro His Ile Ile Asn Leu Leu Val Asp
    530                 535                 540                 
Ser Ile Lys Ile
545             


<210> 296
<211> 520
<212> PRT
<213> Hyoscyamus muticus

<220> 
<223> Hyoscyamus muticus premnaspirodiene synthase

<400> 296
Val Asp Asn Gln Val Ala Glu Lys Tyr Ala Gln Glu Ile Glu Thr Leu
 1               5                  10                  15      
Lys Glu Gln Thr Ser Thr Met Leu Ser Ala Ala Cys Gly Thr Thr Leu
            20                  25                  30          
Thr Glu Lys Leu Asn Leu Ile Asp Ile Ile Glu Arg Leu Gly Ile Ala
        35                  40                  45              
Tyr His Phe Glu Lys Gln Ile Glu Asp Met Leu Asp His Ile Tyr Arg
    50                  55                  60                  
Ala Asp Pro Tyr Phe Glu Ala His Glu Tyr Asn Asp Leu Asn Thr Ser
65                  70                  75                  80  
Ser Val Gln Phe Arg Leu Leu Arg Gln His Gly Tyr Asn Val Ser Pro
                85                  90                  95      
Asn Ile Phe Ser Arg Phe Gln Asp Ala Asn Gly Lys Phe Lys Glu Ser
            100                 105                 110         
Leu Arg Ser Asp Ile Arg Gly Leu Leu Asn Leu Tyr Glu Ala Ser His
        115                 120                 125             
Val Arg Thr His Lys Glu Asp Ile Leu Glu Glu Ala Leu Val Phe Ser
    130                 135                 140                 
Val Gly His Leu Glu Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ser
145                 150                 155                 160 
Lys Gln Val Thr His Ala Leu Glu Gln Ser Leu His Lys Ser Ile Pro
                165                 170                 175     
Arg Val Glu Ile Arg Tyr Phe Ile Ser Ile Tyr Glu Glu Glu Glu Phe
            180                 185                 190         
Lys Asn Asp Leu Leu Leu Arg Phe Ala Lys Leu Asp Tyr Asn Leu Leu
        195                 200                 205             
Gln Met Leu His Lys His Glu Leu Ser Glu Val Ser Arg Trp Trp Lys
    210                 215                 220                 
Asp Leu Asp Phe Val Thr Thr Leu Pro Tyr Ala Arg Asp Arg Ala Val
225                 230                 235                 240 
Glu Cys Tyr Phe Trp Thr Met Gly Val Tyr Ala Glu Pro Gln Tyr Ser
                245                 250                 255     
Gln Ala Arg Val Met Leu Ala Lys Thr Ile Ala Met Ile Ser Ile Val
            260                 265                 270         
Asp Asp Thr Phe Asp Ala Tyr Gly Ile Val Lys Glu Leu Glu Val Tyr
        275                 280                 285             
Thr Asp Ala Ile Gln Arg Trp Asp Ile Ser Gln Ile Asp Arg Leu Pro
    290                 295                 300                 
Glu Tyr Met Lys Ile Ser Tyr Lys Ala Leu Leu Asp Leu Tyr Asp Asp
305                 310                 315                 320 
Tyr Glu Lys Glu Leu Ser Lys Asp Gly Arg Ser Asp Val Val His Tyr
                325                 330                 335     
Ala Lys Glu Arg Met Lys Glu Ile Val Gly Asn Tyr Phe Ile Glu Gly
            340                 345                 350         
Lys Trp Phe Ile Glu Gly Tyr Met Pro Ser Val Ser Glu Tyr Leu Ser
        355                 360                 365             
Asn Ala Leu Ala Thr Ser Thr Tyr Tyr Leu Leu Thr Thr Thr Ser Tyr
    370                 375                 380                 
Leu Gly Met Lys Ser Ala Thr Lys Glu His Phe Glu Trp Leu Ala Thr
385                 390                 395                 400 
Asn Pro Lys Ile Leu Glu Ala Asn Ala Thr Leu Cys Arg Val Val Asp
                405                 410                 415     
Asp Ile Ala Thr Tyr Glu Val Glu Lys Gly Arg Gly Gln Ile Ala Thr
            420                 425                 430         
Gly Ile Glu Cys Tyr Met Arg Asp Tyr Gly Val Ser Thr Glu Val Ala
        435                 440                 445             
Met Glu Lys Phe Gln Glu Met Ala Asp Ile Ala Trp Lys Asp Val Asn
    450                 455                 460                 
Glu Glu Ile Leu Arg Pro Thr Pro Val Ser Ser Glu Ile Leu Thr Arg
465                 470                 475                 480 
Ile Leu Asn Leu Ala Arg Ile Ile Asp Val Thr Tyr Lys His Asn Gln
                485                 490                 495     
Asp Gly Tyr Thr His Pro Glu Lys Val Leu Lys Pro His Ile Ile Ala
            500                 505                 510         
Leu Val Val Asp Ser Ile Asp Ile
        515                 520 


<210> 297
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer 11-157.7

<400> 297
aaggtaccat ttaaaaaaat gtc                                         23

<210> 298
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer 11-157.8

<400> 298
tttctctaga ttaaaatgga aca                                         23

<210> 299
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-1

<400> 299
aaattgccat atgctagaga tagattggtt gaattgtact tttgggattt g          51

<210> 300
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-2

<400> 300
aaattgccat atgctagaga tagacttgtt gaattgtact tttgggattt g          51

<210> 301
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-3

<400> 301
gatttttcta ccaaaagcgt attgtgrttc aaaataagtm cccaaatccc aaaagtac   58

<210> 302
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-4

<400> 302
gatttttcta ccaaaagcgt aagatgrttc aaaataagtm cccaaatccc aaaagtac   58

<210> 303
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-5

<400> 303
gatttttcta ccaaaagcgt acagtgrttc aaaataagtm cccaaatccc aaaagtac   58

<210> 304
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-6

<400> 304
cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt gatgatacct 60
acgatg                                                            66

<210> 305
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-7

<400> 305
cttttggtag aaaaatcatg actaaattga actacatttt gtcctacatt gatgatacct 60
acgatg                                                            66

<210> 306
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-8

<400> 306
gaacaaagac aattcttcca aagtaccgta agcatcgtag gtatcatc              48

<210> 307
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-9

<400> 307
ggtgaacaaa gacaattctt cgtgagtacc gtaagcatcg taggtatcat c          51

<210> 308
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-10

<400> 308
ggtgaacaaa gacaattcgg kcaaagtacc gtaagcatcg taggtatcat c          51

<210> 309
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-11

<400> 309
ggtgaacaaa gacaattcgg kgtgagtacc gtaagcatcg taggtatcat c          51

<210> 310
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-12

<400> 310
ttcttccaaa gtaccgtaag catcgtaggt atcatc                           36

<210> 311
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-13

<400> 311
caattcttcc aaagtaccgt aagcatcgta ggtatcatc                        39

<210> 312
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-14

<400> 312
rtcagcttca ctgaacakcg wgcattcggk gtgagtaccg taagcatcgt aggtatcatc 60


<210> 313
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-15

<400> 313
vccagcttca ctgaacakcg wgcattcggk gtgagtaccg taagcatcgt aggtatcatc 60


<210> 314
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-16

<400> 314
gaattgtctt tgttcaccga agctgttgct cgttggaaca ttgaagc               47

<210> 315
<211> 59
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-17

<400> 315
ggtactttgg aagaattgwc gmtgttcacc gaagctgttg ctcgttggaa cattgaagc  59

<210> 316
<211> 64
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-18

<400> 316
cttacggtac tttggaagaa tgcwcgmtgt tcaccgaagc tgttgctcgt tggaacattg 60
aagc                                                              64

<210> 317
<211> 64
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-19

<400> 317
cttacggtac tttggaagaa tgcwcgmtgt tctcagaagc tgttgctcgt tggaacattg 60
aagc                                                              64

<210> 318
<211> 64
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-20

<400> 318
cttacggtac tttggaagaa tgcwcgmtgt tcagtgaagc tgttgctcgt tggaacattg 60
aagc                                                              64

<210> 319
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-21

<400> 319
gaagaattgt ctttgttctc agaagctgay gctcgttgga acattgaagc            50

<210> 320
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-22

<400> 320
gaagaattgt ctttgttctc agaagctggb gctcgttgga acattgaagc            50

<210> 321
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-23

<400> 321
gaagaattgt ctttgttcag tgaagctgay gctcgttgga acattgaagc            50

<210> 322
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-24

<400> 322
gaagaattgt ctttgttcag tgaagctggb gctcgttgga acattgaagc            50

<210> 323
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-25

<400> 323
gaagaattgt ctttgttcag tgaagctgtt gctcgttgga acattgaagc            50

<210> 324
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-26

<400> 324
gaagaattgt ctttgttctc agaagctgtt gctcgttgga acattgaagc            50

<210> 325
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-27

<400> 325
gaagaattgt ctttgttcac cgaagctgay gctcgttgga acattgaagc            50

<210> 326
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-28

<400> 326
gaagaattgt ctttgttcac cgaagctggb gctcgttgga acattgaagc            50

<210> 327
<211> 53
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-29

<400> 327
cacmccgaat gcwcgmtgtt cagtgaagct ggbgctcgtt ggaacattga agc        53

<210> 328
<211> 53
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-30

<400> 328
cacmccgaat gcwcgmtgtt cagtgaagct gaygctcgtt ggaacattga agc        53

<210> 329
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-31

<400> 329
tctgtagatt aacttcatat aatctggcaa catgtcaaca gcttcaatgt tccaacgagc 60


<210> 330
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-32

<400> 330
tctgtagatw awtcgcatat aatctggcaa catgtcaaca gcttcaatgt tccaacgagc 60


<210> 331
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-33

<400> 331
atatgaagtt aatctacaga actttgttgg atacattcaa cgaaatagaa gaggatatgg 60


<210> 332
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-34

<400> 332
atatgaagwt watctacaga actttgttgg atacattctt ggaaatagaa gaggatatgg 60


<210> 333
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-35

<400> 333
atatgcgawt watctacaga actttgttgg atacattcaa cgaaatagaa gaggatatgg 60


<210> 334
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-36

<400> 334
atatgcgawt watctacaga actttgttgg atacattctt ggaaatagaa gaggatatgg 60


<210> 335
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-37

<400> 335
acaatgagat ctmcgttgtt tagccatatc ctcttctatt tc                    42

<210> 336
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-73-38

<400> 336
acaatgagat ctaccttgtt tagccatatc ctcttctatt tc                    42

<210> 337
<211> 59
<212> DNA
<213> Artificial Sequence

<220> 
<223> mutCVS2-7

<220> 
<221> variation      
<222> (23)...(40)
<223> n = a, c, t or g

<400> 337
ctcggtacca tttaaaaaaa tgnnnnnnnn nnnnnnnnnn agaccaactg ctgattttc  59

<210> 338
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> 7-10.3

<400> 338
ccaagctgaa ttcgagctcg                                             20

<210> 339
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> 7-10.4

<400> 339
acttgaccaa acctctggcg                                             20

<210> 340
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-108-1

<220> 
<221> variation      
<222> (16)...(33)
<223> n = a, c, g or t

<400> 340
gttagaagaa tgattnnnnn nnnnnnnnnn nnnccaattc aaaaattg              48

<210> 341
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-108-2

<220> 
<221> variation      
<222> (16)...(33)
<223> n = a, c, t or g

<400> 341
caatttttga attggnnnnn nnnnnnnnnn nnnaatcatt cttctaac              48

<210> 342
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-108-3

<400> 342
gttagaagaa tgattttagc aaccggaagg aaaccaattc aaaaattg              48

<210> 343
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> 21-108-4

<400> 343
caatttttga attggtttcc ttccggttgc taaaatcatt cttctaac              48

<210> 344
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVSpcrF1

<400> 344
cattcacgca cactactctc t                                           21

<210> 345
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVSpcrR1

<400> 345
gccgacaacc ttgattggag                                             20

<210> 346
<211> 556
<212> PRT
<213> Vitis vinifera

<220> 
<223> Valencene Synthase Uniprot Acc. No. C1JXK7

<400> 346
Met Ser Thr Gln Val Ser Ala Ser Ser Leu Ala Gln Ile Pro Gln Pro
 1               5                  10                  15      
Lys Asn Arg Pro Val Ala Asn Phe His Pro Asn Ile Trp Gly Asp Gln
            20                  25                  30          
Phe Ile Thr Tyr Thr Pro Glu Asp Lys Val Thr Arg Ala Cys Lys Glu
        35                  40                  45              
Glu Gln Ile Glu Asp Leu Lys Lys Glu Val Lys Arg Lys Leu Thr Ala
    50                  55                  60                  
Ala Ala Val Ala Asn Pro Ser Gln Leu Leu Asn Phe Ile Asp Ala Val
65                  70                  75                  80  
Gln Arg Leu Gly Val Ala Tyr His Phe Glu Gln Glu Ile Glu Glu Ala
                85                  90                  95      
Leu Gln His Ile Cys Asn Ser Phe His Asp Cys Asn Asp Met Asp Gly
            100                 105                 110         
Asp Leu Tyr Asn Ile Ala Leu Gly Phe Arg Leu Leu Arg Gln Gln Gly
        115                 120                 125             
Tyr Thr Ile Ser Cys Asp Ile Phe Asn Lys Phe Thr Asp Glu Arg Gly
    130                 135                 140                 
Arg Phe Lys Glu Ala Leu Ile Ser Asp Val Arg Gly Met Leu Gly Leu
145                 150                 155                 160 
Tyr Glu Ala Ala His Leu Arg Val His Gly Glu Asp Ile Leu Ala Lys
                165                 170                 175     
Ala Leu Ala Phe Thr Thr Thr His Leu Lys Ala Met Val Glu Ser Leu
            180                 185                 190         
Gly Tyr His Leu Ala Glu Gln Val Ala His Ala Leu Asn Arg Pro Ile
        195                 200                 205             
Arg Lys Gly Leu Glu Arg Leu Glu Ala Arg Trp Tyr Ile Ser Val Tyr
    210                 215                 220                 
Gln Asp Glu Ala Phe His Asp Lys Thr Leu Leu Glu Leu Ala Lys Leu
225                 230                 235                 240 
Asp Phe Asn Leu Val Gln Ser Leu His Lys Glu Glu Leu Ser Asn Leu
                245                 250                 255     
Ala Arg Trp Trp Lys Glu Leu Asp Phe Ala Thr Lys Leu Pro Phe Ala
            260                 265                 270         
Arg Asp Arg Leu Val Glu Gly Tyr Phe Trp Met His Gly Val Tyr Phe
        275                 280                 285             
Glu Pro Gln Tyr Leu Arg Gly Arg Arg Ile Leu Thr Lys Val Ile Ala
    290                 295                 300                 
Met Thr Ser Ile Leu Asp Asp Ile His Asp Ala Tyr Gly Thr Pro Glu
305                 310                 315                 320 
Glu Leu Lys Leu Phe Ile Glu Ala Ile Glu Arg Trp Asp Ile Asn Ser
                325                 330                 335     
Ile Asn Gln Leu Pro Glu Tyr Met Lys Leu Cys Tyr Val Ala Leu Leu
            340                 345                 350         
Asp Val Tyr Lys Glu Ile Glu Glu Glu Met Glu Lys Glu Gly Asn Gln
        355                 360                 365             
Tyr Arg Val His Tyr Ala Lys Glu Val Met Lys Asn Gln Val Arg Ala
    370                 375                 380                 
Tyr Phe Ala Glu Ala Lys Trp Leu His Glu Glu His Val Pro Ala Phe
385                 390                 395                 400 
Glu Glu Tyr Met Arg Val Ala Leu Ala Ser Ser Gly Tyr Cys Leu Leu
                405                 410                 415     
Ala Thr Thr Ser Phe Val Gly Met Gly Glu Ile Ala Thr Lys Glu Ala
            420                 425                 430         
Phe Asp Trp Val Thr Ser Asp Pro Lys Ile Met Ser Ser Ser Asn Phe
        435                 440                 445             
Ile Thr Arg Leu Met Asp Asp Ile Lys Ser His Lys Phe Glu Gln Lys
    450                 455                 460                 
Arg Gly His Val Ala Ser Ala Val Glu Cys Tyr Met Lys Gln Tyr Gly
465                 470                 475                 480 
Val Ser Glu Glu Gln Val Tyr Ser Glu Phe Gln Lys Gln Ile Glu Asn
                485                 490                 495     
Ala Trp Leu Asp Ile Asn Gln Glu Cys Leu Lys Pro Thr Ala Val Ser
            500                 505                 510         
Met Pro Leu Leu Ala Arg Leu Leu Asn Leu Thr Arg Thr Met Asp Val
        515                 520                 525             
Ile Tyr Lys Glu Gln Asp Ser Tyr Thr His Val Gly Lys Val Met Arg
    530                 535                 540                 
Asp Asn Ile Ala Ser Val Phe Ile Asn Ala Val Ile
545                 550                 555     


<210> 347
<211> 556
<212> PRT
<213> Vitis vinifera

<220> 
<223> Valencene Synthase Uniprot Acc. No. Q6Q3H2

<400> 347
Met Ser Thr Gln Val Ser Ala Ser Ser Leu Ala Gln Ile Pro Gln Pro
 1               5                  10                  15      
Lys Asn Arg Pro Val Ala Asn Phe His Pro Asn Ile Trp Gly Asp Gln
            20                  25                  30          
Phe Ile Thr Tyr Thr Pro Glu Asp Lys Val Thr Arg Ala Cys Lys Glu
        35                  40                  45              
Glu Gln Ile Glu Asp Leu Lys Lys Glu Val Lys Arg Lys Leu Thr Ala
    50                  55                  60                  
Ala Ala Val Ala Asn Pro Ser Gln Leu Leu Asn Phe Ile Asp Ala Val
65                  70                  75                  80  
Gln Arg Leu Gly Val Ala Tyr His Phe Glu Gln Glu Ile Glu Glu Ala
                85                  90                  95      
Leu Gln His Ile Cys Asn Ser Phe His Asp Cys Asn Asp Met Asp Gly
            100                 105                 110         
Asp Leu Tyr Asn Ile Ala Leu Gly Phe Arg Leu Leu Arg Gln Gln Gly
        115                 120                 125             
Tyr Thr Ile Ser Cys Asp Ile Phe Asn Lys Phe Thr Asp Glu Arg Gly
    130                 135                 140                 
Arg Phe Lys Glu Ala Leu Ile Ser Asp Val Arg Gly Met Leu Gly Leu
145                 150                 155                 160 
Tyr Glu Ala Ala His Leu Arg Val His Gly Glu Asp Ile Leu Ala Lys
                165                 170                 175     
Ala Leu Ala Phe Thr Thr Thr His Leu Lys Ala Met Val Glu Ser Leu
            180                 185                 190         
Gly Tyr His Leu Ala Glu Gln Val Ala His Ala Leu Asn Arg Pro Ile
        195                 200                 205             
Arg Lys Gly Leu Glu Arg Leu Glu Ala Arg Trp Tyr Ile Ser Val Tyr
    210                 215                 220                 
Gln Asp Glu Ala Phe His Asp Lys Thr Leu Leu Glu Leu Ala Lys Leu
225                 230                 235                 240 
Asp Phe Asn Leu Val Gln Ser Leu His Lys Glu Glu Leu Ser Asn Leu
                245                 250                 255     
Ala Arg Trp Trp Lys Glu Leu Asp Phe Ala Thr Lys Leu Pro Phe Ala
            260                 265                 270         
Arg Asp Arg Leu Val Glu Gly Tyr Phe Trp Met His Gly Val Tyr Phe
        275                 280                 285             
Glu Pro Gln Tyr Leu Arg Gly Arg Arg Ile Leu Thr Lys Val Ile Ala
    290                 295                 300                 
Met Thr Ser Ile Leu Asp Asp Ile His Asp Ala Tyr Gly Thr Pro Glu
305                 310                 315                 320 
Glu Leu Lys Leu Phe Ile Glu Ala Ile Glu Arg Trp Asp Ile Asn Ser
                325                 330                 335     
Ile Asn Gln Leu Pro Glu Tyr Met Lys Leu Cys Tyr Val Ala Leu Leu
            340                 345                 350         
Asp Val Tyr Lys Glu Ile Glu Glu Glu Met Glu Lys Glu Gly Asn Gln
        355                 360                 365             
Tyr Arg Val His Tyr Ala Lys Glu Val Met Lys Asn Gln Val Arg Ala
    370                 375                 380                 
Tyr Phe Ala Glu Ala Lys Trp Leu His Glu Glu His Val Pro Ala Phe
385                 390                 395                 400 
Glu Glu Tyr Met Arg Val Ala Leu Ala Ser Ser Gly Tyr Cys Leu Leu
                405                 410                 415     
Ala Thr Thr Ser Phe Val Gly Met Gly Glu Ile Ala Thr Lys Glu Ala
            420                 425                 430         
Phe Asp Trp Val Thr Ser Asp Pro Lys Ile Met Ser Ser Ser Asn Phe
        435                 440                 445             
Ile Thr Arg Leu Met Asp Asp Ile Lys Ser His Lys Phe Glu Gln Lys
    450                 455                 460                 
Arg Gly His Val Thr Ser Ala Val Glu Cys Tyr Met Lys Gln Tyr Gly
465                 470                 475                 480 
Val Ser Glu Glu Gln Val Tyr Ser Glu Phe Gln Lys Gln Ile Glu Asn
                485                 490                 495     
Ala Trp Leu Asp Ile Asn Gln Glu Cys Leu Lys Pro Thr Ala Val Ser
            500                 505                 510         
Met Pro Leu Leu Ala Arg Leu Leu Asn Phe Thr Arg Thr Met Asp Val
        515                 520                 525             
Ile Tyr Lys Glu Gln Asp Ser Tyr Thr His Val Gly Lys Val Met Arg
    530                 535                 540                 
Asp Asn Ile Ala Ser Val Phe Ile Asn Ala Val Ile
545                 550                 555     


<210> 348
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V11

<400> 348
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asp Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Ser Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 349
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V11

<400> 349
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaagaaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa taaagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcaga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatcg attcaacaag tgatcattta 660
tacaataaaa ctctgctgag ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acagattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 350
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V229

<400> 350
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Leu Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 351
<211> 547
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V230 and V231

<400> 351
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro
545         


<210> 352
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V229

<400> 352
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgcgaat aatctacaga 1020
actttgttgg atacattctt ggaaatagaa gaggatatgg ctaaacaacg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 353
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V230 and V231

<400> 353
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 354
<211> 565
<212> PRT
<213> Actinidia deliciosa

<220> 
<223> germacrene-D synthase Acc. No. AAX16121.1

<400> 354
Met Gln Leu Pro Cys Ala Gln Ala Leu Pro Ile Pro Thr Val Thr Thr
 1               5                  10                  15      
Thr Thr Ser Ile Glu Pro Pro His Val Thr Arg Arg Ser Ala Asn Tyr
            20                  25                  30          
His Pro Ser Ile Trp Gly Asp His Phe Leu Ala Tyr Ser Ser Asp Ala
        35                  40                  45              
Met Glu Glu Glu Val Ile Asn Met Glu Gln Gln Gln Arg Leu His His
    50                  55                  60                  
Leu Lys Gln Lys Val Arg Lys Met Leu Glu Ala Ala Ala Glu Gln Ser
65                  70                  75                  80  
Ser Gln Met Leu Asn Leu Val Asp Lys Ile Gln Arg Leu Gly Val Ser
                85                  90                  95      
Tyr His Phe Glu Thr Glu Ile Glu Thr Ala Leu Arg His Ile Tyr Lys
            100                 105                 110         
Thr Cys Asp Tyr His Phe Asp Asp Leu His Thr Ala Ala Leu Ser Phe
        115                 120                 125             
Arg Leu Leu Arg Gln Gln Gly Tyr Pro Val Ser Cys Asp Met Phe Asp
    130                 135                 140                 
Lys Phe Lys Asn Ser Lys Gly Glu Phe Gln Glu Ser Ile Ile Ser Asp
145                 150                 155                 160 
Val Gln Gly Met Leu Ser Leu Tyr Glu Ala Thr Cys Leu Arg Ile His
                165                 170                 175     
Gly Glu Asp Ile Leu Asp Glu Ala Leu Ala Phe Thr Ile Thr Gln Leu
            180                 185                 190         
Arg Ser Ala Leu Pro Asn Leu Ser Thr Pro Phe Lys Glu Gln Ile Ile
        195                 200                 205             
His Ala Leu Asn Gln Pro Ile His Lys Gly Leu Thr Arg Leu Asn Ala
    210                 215                 220                 
Arg Ser His Ile Leu Phe Phe Glu Gln Asn Asp Cys His Ser Lys Asp
225                 230                 235                 240 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Leu Leu Gln Lys Leu His
                245                 250                 255     
Gln Arg Glu Leu Cys Glu Ile Thr Arg Trp Trp Lys Asp Leu Asn Phe
            260                 265                 270         
Ala Lys Thr Leu Pro Phe Ala Arg Asp Arg Met Val Glu Cys Tyr Phe
        275                 280                 285             
Trp Ile Leu Gly Val Tyr Phe Glu Pro Gln Tyr Leu Leu Ala Arg Arg
    290                 295                 300                 
Met Leu Thr Lys Val Ile Ala Met Ile Ser Ile Ile Asp Asp Ile Tyr
305                 310                 315                 320 
Asp Val Tyr Gly Thr Leu Glu Glu Leu Val Leu Phe Thr Asp Ala Ile
                325                 330                 335     
Glu Arg Trp Glu Ile Ser Ala Leu Asp Gln Leu Pro Glu Tyr Met Lys
            340                 345                 350         
Leu Cys Tyr Gln Ala Leu Leu Asp Val Tyr Ser Met Ile Asp Glu Glu
        355                 360                 365             
Met Ala Lys Gln Gly Arg Ser Tyr Cys Val Asp Tyr Ala Lys Ser Ser
    370                 375                 380                 
Met Lys Ile Leu Val Arg Ala Tyr Phe Glu Glu Ala Lys Trp Phe His
385                 390                 395                 400 
Gln Gly Tyr Val Pro Thr Met Glu Glu Tyr Met Gln Val Ala Leu Val
                405                 410                 415     
Thr Ala Gly Tyr Lys Met Leu Ala Thr Ser Ser Phe Val Gly Met Gly
            420                 425                 430         
Asp Leu Ala Thr Lys Glu Ala Phe Asp Trp Val Ser Asn Asp Pro Leu
        435                 440                 445             
Ile Val Gln Ala Ala Ser Val Ile Gly Arg Leu Lys Asp Asp Ile Val
    450                 455                 460                 
Gly His Lys Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Val Glu
465                 470                 475                 480 
Cys Tyr Ser Lys Gln His Gly Thr Thr Glu Glu Glu Ala Ile Ile Glu
                485                 490                 495     
Leu Asp Lys Gln Val Thr His Ser Trp Lys Asp Ile Asn Ala Glu Cys
            500                 505                 510         
Leu Cys Pro Ile Lys Val Pro Met Pro Leu Leu Ala Arg Val Leu Asn
        515                 520                 525             
Leu Ala Arg Val Leu Tyr Val Ile Tyr Gln Asp Glu Asp Gly Tyr Thr
    530                 535                 540                 
His Pro Gly Thr Lys Val Glu Asn Phe Val Thr Ser Val Leu Ile Asp
545                 550                 555                 560 
Ser Met Pro Ile Asn
                565 


<210> 355
<211> 868
<212> PRT
<213> Abies grandis

<220> 
<223> abietadiene cyclase Acc. No. AAB05407.1

<400> 355
Met Ala Met Pro Ser Ser Ser Leu Ser Ser Gln Ile Pro Thr Ala Ala
 1               5                  10                  15      
His His Leu Thr Ala Asn Ala Gln Ser Ile Pro His Phe Ser Thr Thr
            20                  25                  30          
Leu Asn Ala Gly Ser Ser Ala Ser Lys Arg Arg Ser Leu Tyr Leu Arg
        35                  40                  45              
Trp Gly Lys Gly Ser Asn Lys Ile Ile Ala Cys Val Gly Glu Gly Gly
    50                  55                  60                  
Ala Thr Ser Val Pro Tyr Gln Ser Ala Glu Lys Asn Asp Ser Leu Ser
65                  70                  75                  80  
Ser Ser Thr Leu Val Lys Arg Glu Phe Pro Pro Gly Phe Trp Lys Asp
                85                  90                  95      
Asp Leu Ile Asp Ser Leu Thr Ser Ser His Lys Val Ala Ala Ser Asp
            100                 105                 110         
Glu Lys Arg Ile Glu Thr Leu Ile Ser Glu Ile Lys Asn Met Phe Arg
        115                 120                 125             
Cys Met Gly Tyr Gly Glu Thr Asn Pro Ser Ala Tyr Asp Thr Ala Trp
    130                 135                 140                 
Val Ala Arg Ile Pro Ala Val Asp Gly Ser Asp Asn Pro His Phe Pro
145                 150                 155                 160 
Glu Thr Val Glu Trp Ile Leu Gln Asn Gln Leu Lys Asp Gly Ser Trp
                165                 170                 175     
Gly Glu Gly Phe Tyr Phe Leu Ala Tyr Asp Arg Ile Leu Ala Thr Leu
            180                 185                 190         
Ala Cys Ile Ile Thr Leu Thr Leu Trp Arg Thr Gly Glu Thr Gln Val
        195                 200                 205             
Gln Lys Gly Ile Glu Phe Phe Arg Thr Gln Ala Gly Lys Met Glu Asp
    210                 215                 220                 
Glu Ala Asp Ser His Arg Pro Ser Gly Phe Glu Ile Val Phe Pro Ala
225                 230                 235                 240 
Met Leu Lys Glu Ala Lys Ile Leu Gly Leu Asp Leu Pro Tyr Asp Leu
                245                 250                 255     
Pro Phe Leu Lys Gln Ile Ile Glu Lys Arg Glu Ala Lys Leu Lys Arg
            260                 265                 270         
Ile Pro Thr Asp Val Leu Tyr Ala Leu Pro Thr Thr Leu Leu Tyr Ser
        275                 280                 285             
Leu Glu Gly Leu Gln Glu Ile Val Asp Trp Gln Lys Ile Met Lys Leu
    290                 295                 300                 
Gln Ser Lys Asp Gly Ser Phe Leu Ser Ser Pro Ala Ser Thr Ala Ala
305                 310                 315                 320 
Val Phe Met Arg Thr Gly Asn Lys Lys Cys Leu Asp Phe Leu Asn Phe
                325                 330                 335     
Val Leu Lys Lys Phe Gly Asn His Val Pro Cys His Tyr Pro Leu Asp
            340                 345                 350         
Leu Phe Glu Arg Leu Trp Ala Val Asp Thr Val Glu Arg Leu Gly Ile
        355                 360                 365             
Asp Arg His Phe Lys Glu Glu Ile Lys Glu Ala Leu Asp Tyr Val Tyr
    370                 375                 380                 
Ser His Trp Asp Glu Arg Gly Ile Gly Trp Ala Arg Glu Asn Pro Val
385                 390                 395                 400 
Pro Asp Ile Asp Asp Thr Ala Met Gly Leu Arg Ile Leu Arg Leu His
                405                 410                 415     
Gly Tyr Asn Val Ser Ser Asp Val Leu Lys Thr Phe Arg Asp Glu Asn
            420                 425                 430         
Gly Glu Phe Phe Cys Phe Leu Gly Gln Thr Gln Arg Gly Val Thr Asp
        435                 440                 445             
Met Leu Asn Val Asn Arg Cys Ser His Val Ser Phe Pro Gly Glu Thr
    450                 455                 460                 
Ile Met Glu Glu Ala Lys Leu Cys Thr Glu Arg Tyr Leu Arg Asn Ala
465                 470                 475                 480 
Leu Glu Asn Val Asp Ala Phe Asp Lys Trp Ala Phe Lys Lys Asn Ile
                485                 490                 495     
Arg Gly Glu Val Glu Tyr Ala Leu Lys Tyr Pro Trp His Lys Ser Met
            500                 505                 510         
Pro Arg Leu Glu Ala Arg Ser Tyr Ile Glu Asn Tyr Gly Pro Asp Asp
        515                 520                 525             
Val Trp Leu Gly Lys Thr Val Tyr Met Met Pro Tyr Ile Ser Asn Glu
    530                 535                 540                 
Lys Tyr Leu Glu Leu Ala Lys Leu Asp Phe Asn Lys Val Gln Ser Ile
545                 550                 555                 560 
His Gln Thr Glu Leu Gln Asp Leu Arg Arg Trp Trp Lys Ser Ser Gly
                565                 570                 575     
Phe Thr Asp Leu Asn Phe Thr Arg Glu Arg Val Thr Glu Ile Tyr Phe
            580                 585                 590         
Ser Pro Ala Ser Phe Ile Phe Glu Pro Glu Phe Ser Lys Cys Arg Glu
        595                 600                 605             
Val Tyr Thr Lys Thr Ser Asn Phe Thr Val Ile Leu Asp Asp Leu Tyr
    610                 615                 620                 
Asp Ala His Gly Ser Leu Asp Asp Leu Lys Leu Phe Thr Glu Ser Val
625                 630                 635                 640 
Lys Arg Trp Asp Leu Ser Leu Val Asp Gln Met Pro Gln Gln Met Lys
                645                 650                 655     
Ile Cys Phe Val Gly Phe Tyr Asn Thr Phe Asn Asp Ile Ala Lys Glu
            660                 665                 670         
Gly Arg Glu Arg Gln Gly Arg Asp Val Leu Gly Tyr Ile Gln Asn Val
        675                 680                 685             
Trp Lys Val Gln Leu Glu Ala Tyr Thr Lys Glu Ala Glu Trp Ser Glu
    690                 695                 700                 
Ala Lys Tyr Val Pro Ser Phe Asn Glu Tyr Ile Glu Asn Ala Ser Val
705                 710                 715                 720 
Ser Ile Ala Leu Gly Thr Val Val Leu Ile Ser Ala Leu Phe Thr Gly
                725                 730                 735     
Glu Val Leu Thr Asp Glu Val Leu Ser Lys Ile Asp Arg Glu Ser Arg
            740                 745                 750         
Phe Leu Gln Leu Met Gly Leu Thr Gly Arg Leu Val Asn Asp Thr Lys
        755                 760                 765             
Thr Tyr Gln Ala Glu Arg Gly Gln Gly Glu Val Ala Ser Ala Ile Gln
    770                 775                 780                 
Cys Tyr Met Lys Asp His Pro Lys Ile Ser Glu Glu Glu Ala Leu Gln
785                 790                 795                 800 
His Val Tyr Ser Val Met Glu Asn Ala Leu Glu Glu Leu Asn Arg Glu
                805                 810                 815     
Phe Val Asn Asn Lys Ile Pro Asp Ile Tyr Lys Arg Leu Val Phe Glu
            820                 825                 830         
Thr Ala Arg Ile Met Gln Leu Phe Tyr Met Gln Gly Asp Gly Leu Thr
        835                 840                 845             
Leu Ser His Asp Met Glu Ile Lys Glu His Val Lys Asn Cys Leu Phe
    850                 855                 860                 
Gln Pro Val Ala
865             


<210> 356
<211> 628
<212> PRT
<213> Abies grandis

<220> 
<223> pinene synthase Acc. No. O24475

<400> 356
Met Ala Leu Val Ser Thr Ala Pro Leu Ala Ser Lys Ser Cys Leu His
 1               5                  10                  15      
Lys Ser Leu Ile Ser Ser Thr His Glu Leu Lys Ala Leu Ser Arg Thr
            20                  25                  30          
Ile Pro Ala Leu Gly Met Ser Arg Arg Gly Lys Ser Ile Thr Pro Ser
        35                  40                  45              
Ile Ser Met Ser Ser Thr Thr Val Val Thr Asp Asp Gly Val Arg Arg
    50                  55                  60                  
Arg Met Gly Asp Phe His Ser Asn Leu Trp Asp Asp Asp Val Ile Gln
65                  70                  75                  80  
Ser Leu Pro Thr Ala Tyr Glu Glu Lys Ser Tyr Leu Glu Arg Ala Glu
                85                  90                  95      
Lys Leu Ile Gly Glu Val Lys Asn Met Phe Asn Ser Met Ser Leu Glu
            100                 105                 110         
Asp Gly Glu Leu Met Ser Pro Leu Asn Asp Leu Ile Gln Arg Leu Trp
        115                 120                 125             
Ile Val Asp Ser Leu Glu Arg Leu Gly Ile His Arg His Phe Lys Asp
    130                 135                 140                 
Glu Ile Lys Ser Ala Leu Asp Tyr Val Tyr Ser Tyr Trp Gly Glu Asn
145                 150                 155                 160 
Gly Ile Gly Cys Gly Arg Glu Ser Val Val Thr Asp Leu Asn Ser Thr
                165                 170                 175     
Ala Leu Gly Leu Arg Thr Leu Arg Leu His Gly Tyr Pro Val Ser Ser
            180                 185                 190         
Asp Val Phe Lys Ala Phe Lys Gly Gln Asn Gly Gln Phe Ser Cys Ser
        195                 200                 205             
Glu Asn Ile Gln Thr Asp Glu Glu Ile Arg Gly Val Leu Asn Leu Phe
    210                 215                 220                 
Arg Ala Ser Leu Ile Ala Phe Pro Gly Glu Lys Ile Met Asp Glu Ala
225                 230                 235                 240 
Glu Ile Phe Ser Thr Lys Tyr Leu Lys Glu Ala Leu Gln Lys Ile Pro
                245                 250                 255     
Val Ser Ser Leu Ser Arg Glu Ile Gly Asp Val Leu Glu Tyr Gly Trp
            260                 265                 270         
His Thr Tyr Leu Pro Arg Leu Glu Ala Arg Asn Tyr Ile Gln Val Phe
        275                 280                 285             
Gly Gln Asp Thr Glu Asn Thr Lys Ser Tyr Val Lys Ser Lys Lys Leu
    290                 295                 300                 
Leu Glu Leu Ala Lys Leu Glu Phe Asn Ile Phe Gln Ser Leu Gln Lys
305                 310                 315                 320 
Arg Glu Leu Glu Ser Leu Val Arg Trp Trp Lys Glu Ser Gly Phe Pro
                325                 330                 335     
Glu Met Thr Phe Cys Arg His Arg His Val Glu Tyr Tyr Thr Leu Ala
            340                 345                 350         
Ser Cys Ile Ala Phe Glu Pro Gln His Ser Gly Phe Arg Leu Gly Phe
        355                 360                 365             
Ala Lys Thr Cys His Leu Ile Thr Val Leu Asp Asp Met Tyr Asp Thr
    370                 375                 380                 
Phe Gly Thr Val Asp Glu Leu Glu Leu Phe Thr Ala Thr Met Lys Arg
385                 390                 395                 400 
Trp Asp Pro Ser Ser Ile Asp Cys Leu Pro Glu Tyr Met Lys Gly Val
                405                 410                 415     
Tyr Ile Ala Val Tyr Asp Thr Val Asn Glu Met Ala Arg Glu Ala Glu
            420                 425                 430         
Glu Ala Gln Gly Arg Asp Thr Leu Thr Tyr Ala Arg Glu Ala Trp Glu
        435                 440                 445             
Ala Tyr Ile Asp Ser Tyr Met Gln Glu Ala Arg Trp Ile Ala Thr Gly
    450                 455                 460                 
Tyr Leu Pro Ser Phe Asp Glu Tyr Tyr Glu Asn Gly Lys Val Ser Cys
465                 470                 475                 480 
Gly His Arg Ile Ser Ala Leu Gln Pro Ile Leu Thr Met Asp Ile Pro
                485                 490                 495     
Phe Pro Asp His Ile Leu Lys Glu Val Asp Phe Pro Ser Lys Leu Asn
            500                 505                 510         
Asp Leu Ala Cys Ala Ile Leu Arg Leu Arg Gly Asp Thr Arg Cys Tyr
        515                 520                 525             
Lys Ala Asp Arg Ala Arg Gly Glu Glu Ala Ser Ser Ile Ser Cys Tyr
    530                 535                 540                 
Met Lys Asp Asn Pro Gly Val Ser Glu Glu Asp Ala Leu Asp His Ile
545                 550                 555                 560 
Asn Ala Met Ile Ser Asp Val Ile Lys Gly Leu Asn Trp Glu Leu Leu
                565                 570                 575     
Lys Pro Asp Ile Asn Val Pro Ile Ser Ala Lys Lys His Ala Phe Asp
            580                 585                 590         
Ile Ala Arg Ala Phe His Tyr Gly Tyr Lys Tyr Arg Asp Gly Tyr Ser
        595                 600                 605             
Val Ala Asn Val Glu Thr Lys Ser Leu Val Thr Arg Thr Leu Leu Glu
    610                 615                 620                 
Ser Val Pro Leu
625             


<210> 357
<211> 581
<212> PRT
<213> Abies grandis

<220> 
<223> d-selinene synthase Acc. No. AAC05727.1

<400> 357
Met Ala Glu Ile Ser Glu Ser Ser Ile Pro Arg Arg Thr Gly Asn His
 1               5                  10                  15      
His Gly Asn Val Trp Asp Asp Asp Leu Ile His Ser Leu Asn Ser Pro
            20                  25                  30          
Tyr Gly Ala Pro Ala Tyr Tyr Glu Leu Leu Gln Lys Leu Ile Gln Glu
        35                  40                  45              
Ile Lys His Leu Leu Leu Thr Glu Met Glu Met Asp Asp Gly Asp His
    50                  55                  60                  
Asp Leu Ile Lys Arg Leu Gln Ile Val Asp Thr Leu Glu Cys Leu Gly
65                  70                  75                  80  
Ile Asp Arg His Phe Glu His Glu Ile Gln Thr Ala Ala Leu Asp Tyr
                85                  90                  95      
Val Tyr Arg Trp Trp Asn Glu Lys Gly Ile Gly Glu Gly Ser Arg Asp
            100                 105                 110         
Ser Phe Ser Lys Asp Leu Asn Ala Thr Ala Leu Gly Phe Arg Ala Leu
        115                 120                 125             
Arg Leu His Arg Tyr Asn Val Ser Ser Gly Val Leu Lys Asn Phe Lys
    130                 135                 140                 
Asp Glu Asn Gly Lys Phe Phe Cys Asn Phe Thr Gly Glu Glu Gly Arg
145                 150                 155                 160 
Gly Asp Lys Gln Val Arg Ser Met Leu Ser Leu Leu Arg Ala Ser Glu
                165                 170                 175     
Ile Ser Phe Pro Gly Glu Lys Val Met Glu Glu Ala Lys Ala Phe Thr
            180                 185                 190         
Arg Glu Tyr Leu Asn Gln Val Leu Ala Gly His Gly Asp Val Thr Asp
        195                 200                 205             
Val Asp Gln Ser Leu Leu Arg Glu Val Lys Tyr Ala Leu Glu Phe Pro
    210                 215                 220                 
Trp His Cys Ser Val Pro Arg Trp Glu Ala Arg Ser Phe Leu Glu Ile
225                 230                 235                 240 
Tyr Gly His Asn His Ser Trp Leu Lys Ser Asn Ile Asn Gln Lys Met
                245                 250                 255     
Leu Lys Leu Ala Lys Leu Asp Phe Asn Ile Leu Gln Cys Lys His His
            260                 265                 270         
Lys Glu Ile Gln Phe Ile Thr Arg Trp Trp Arg Asp Ser Gly Ile Ser
        275                 280                 285             
Gln Leu Asn Phe Tyr Arg Lys Arg His Val Glu Tyr Tyr Ser Trp Val
    290                 295                 300                 
Val Met Cys Ile Phe Glu Pro Glu Phe Ser Glu Ser Arg Ile Ala Phe
305                 310                 315                 320 
Ala Lys Thr Ala Ile Leu Cys Thr Val Leu Asp Asp Leu Tyr Asp Thr
                325                 330                 335     
His Ala Thr Leu His Glu Ile Lys Ile Met Thr Glu Gly Val Arg Arg
            340                 345                 350         
Trp Asp Leu Ser Leu Thr Asp Asp Leu Pro Asp Tyr Ile Lys Ile Ala
        355                 360                 365             
Phe Gln Phe Phe Phe Asn Thr Val Asn Glu Leu Ile Val Glu Ile Val
    370                 375                 380                 
Lys Arg Gln Gly Arg Asp Met Thr Thr Ile Val Lys Asp Cys Trp Lys
385                 390                 395                 400 
Arg Tyr Ile Glu Ser Tyr Leu Gln Glu Ala Glu Trp Ile Ala Thr Gly
                405                 410                 415     
His Ile Pro Thr Phe Asn Glu Tyr Ile Lys Asn Gly Met Ala Ser Ser
            420                 425                 430         
Gly Met Cys Ile Leu Asn Leu Asn Pro Leu Leu Leu Leu Asp Lys Leu
        435                 440                 445             
Leu Pro Asp Asn Ile Leu Glu Gln Ile His Ser Pro Ser Lys Ile Leu
    450                 455                 460                 
Asp Leu Leu Glu Leu Thr Gly Arg Ile Ala Asp Asp Leu Lys Asp Phe
465                 470                 475                 480 
Glu Asp Glu Lys Glu Arg Gly Glu Met Ala Ser Ser Leu Gln Cys Tyr
                485                 490                 495     
Met Lys Glu Asn Pro Glu Ser Thr Val Glu Asn Ala Leu Asn His Ile
            500                 505                 510         
Lys Gly Ile Leu Asn Arg Ser Leu Glu Glu Phe Asn Trp Glu Phe Met
        515                 520                 525             
Lys Gln Asp Ser Val Pro Met Cys Cys Lys Lys Phe Thr Phe Asn Ile
    530                 535                 540                 
Gly Arg Gly Leu Gln Phe Ile Tyr Lys Tyr Arg Asp Gly Leu Tyr Ile
545                 550                 555                 560 
Ser Asp Lys Glu Val Lys Asp Gln Ile Phe Lys Ile Leu Val His Gln
                565                 570                 575     
Val Pro Met Glu Glu
            580     


<210> 358
<211> 593
<212> PRT
<213> Abies grandis

<220> 
<223> gamma-humulene synthase Acc. No. AAC05728

<400> 358
Met Ala Gln Ile Ser Glu Ser Val Ser Pro Ser Thr Asp Leu Lys Ser
 1               5                  10                  15      
Thr Glu Ser Ser Ile Thr Ser Asn Arg His Gly Asn Met Trp Glu Asp
            20                  25                  30          
Asp Arg Ile Gln Ser Leu Asn Ser Pro Tyr Gly Ala Pro Ala Tyr Gln
        35                  40                  45              
Glu Arg Ser Glu Lys Leu Ile Glu Glu Ile Lys Leu Leu Phe Leu Ser
    50                  55                  60                  
Asp Met Asp Asp Ser Cys Asn Asp Ser Asp Arg Asp Leu Ile Lys Arg
65                  70                  75                  80  
Leu Glu Ile Val Asp Thr Val Glu Cys Leu Gly Ile Asp Arg His Phe
                85                  90                  95      
Gln Pro Glu Ile Lys Leu Ala Leu Asp Tyr Val Tyr Arg Cys Trp Asn
            100                 105                 110         
Glu Arg Gly Ile Gly Glu Gly Ser Arg Asp Ser Leu Lys Lys Asp Leu
        115                 120                 125             
Asn Ala Thr Ala Leu Gly Phe Arg Ala Leu Arg Leu His Arg Tyr Asn
    130                 135                 140                 
Val Ser Ser Gly Val Leu Glu Asn Phe Arg Asp Asp Asn Gly Gln Phe
145                 150                 155                 160 
Phe Cys Gly Ser Thr Val Glu Glu Glu Gly Ala Glu Ala Tyr Asn Lys
                165                 170                 175     
His Val Arg Cys Met Leu Ser Leu Ser Arg Ala Ser Asn Ile Leu Phe
            180                 185                 190         
Pro Gly Glu Lys Val Met Glu Glu Ala Lys Ala Phe Thr Thr Asn Tyr
        195                 200                 205             
Leu Lys Lys Val Leu Ala Gly Arg Glu Ala Thr His Val Asp Glu Ser
    210                 215                 220                 
Leu Leu Gly Glu Val Lys Tyr Ala Leu Glu Phe Pro Trp His Cys Ser
225                 230                 235                 240 
Val Gln Arg Trp Glu Ala Arg Ser Phe Ile Glu Ile Phe Gly Gln Ile
                245                 250                 255     
Asp Ser Glu Leu Lys Ser Asn Leu Ser Lys Lys Met Leu Glu Leu Ala
            260                 265                 270         
Lys Leu Asp Phe Asn Ile Leu Gln Cys Thr His Gln Lys Glu Leu Gln
        275                 280                 285             
Ile Ile Ser Arg Trp Phe Ala Asp Ser Ser Ile Ala Ser Leu Asn Phe
    290                 295                 300                 
Tyr Arg Lys Cys Tyr Val Glu Phe Tyr Phe Trp Met Ala Ala Ala Ile
305                 310                 315                 320 
Ser Glu Pro Glu Phe Ser Gly Ser Arg Val Ala Phe Thr Lys Ile Ala
                325                 330                 335     
Ile Leu Met Thr Met Leu Asp Asp Leu Tyr Asp Thr His Gly Thr Leu
            340                 345                 350         
Asp Gln Leu Lys Ile Phe Thr Glu Gly Val Arg Arg Trp Asp Val Ser
        355                 360                 365             
Leu Val Glu Gly Leu Pro Asp Phe Met Lys Ile Ala Phe Glu Phe Trp
    370                 375                 380                 
Leu Lys Thr Ser Asn Glu Leu Ile Ala Glu Ala Val Lys Ala Gln Gly
385                 390                 395                 400 
Gln Asp Met Ala Ala Tyr Ile Arg Lys Asn Ala Trp Glu Arg Tyr Leu
                405                 410                 415     
Glu Ala Tyr Leu Gln Asp Ala Glu Trp Ile Ala Thr Gly His Val Pro
            420                 425                 430         
Thr Phe Asp Glu Tyr Leu Asn Asn Gly Thr Pro Asn Thr Gly Met Cys
        435                 440                 445             
Val Leu Asn Leu Ile Pro Leu Leu Leu Met Gly Glu His Leu Pro Ile
    450                 455                 460                 
Asp Ile Leu Glu Gln Ile Phe Leu Pro Ser Arg Phe His His Leu Ile
465                 470                 475                 480 
Glu Leu Ala Ser Arg Leu Val Asp Asp Ala Arg Asp Phe Gln Ala Glu
                485                 490                 495     
Lys Asp His Gly Asp Leu Ser Cys Ile Glu Cys Tyr Leu Lys Asp His
            500                 505                 510         
Pro Glu Ser Thr Val Glu Asp Ala Leu Asn His Val Asn Gly Leu Leu
        515                 520                 525             
Gly Asn Cys Leu Leu Glu Met Asn Trp Lys Phe Leu Lys Lys Gln Asp
    530                 535                 540                 
Ser Val Pro Leu Ser Cys Lys Lys Tyr Ser Phe His Val Leu Ala Arg
545                 550                 555                 560 
Ser Ile Gln Phe Met Tyr Asn Gln Gly Asp Gly Phe Ser Ile Ser Asn
                565                 570                 575     
Lys Val Ile Lys Asp Gln Val Gln Lys Val Leu Ile Val Pro Val Pro
            580                 585                 590         
Ile
    


<210> 359
<211> 816
<212> PRT
<213> Abies grandis

<220> 
<223> E-alpha-bisabolene synthase Acc. No. AAK83562

<400> 359
Ala Gly Val Ser Ala Val Ser Lys Val Ser Ser Leu Val Cys Asp Leu
 1               5                  10                  15      
Ser Ser Thr Ser Gly Leu Ile Arg Arg Thr Ala Asn Pro His Pro Asn
            20                  25                  30          
Val Trp Gly Tyr Asp Leu Val His Ser Leu Lys Ser Pro Tyr Ile Asp
        35                  40                  45              
Ser Ser Tyr Arg Glu Arg Ala Glu Val Leu Val Ser Glu Ile Lys Val
    50                  55                  60                  
Met Leu Asn Pro Ala Ile Thr Gly Asp Gly Glu Ser Met Ile Thr Pro
65                  70                  75                  80  
Ser Ala Tyr Asp Thr Ala Trp Val Ala Arg Val Pro Ala Ile Asp Gly
                85                  90                  95      
Ser Ala Arg Pro Gln Phe Pro Gln Thr Val Asp Trp Ile Leu Lys Asn
            100                 105                 110         
Gln Leu Lys Asp Gly Ser Trp Gly Ile Gln Ser His Phe Leu Leu Ser
        115                 120                 125             
Asp Arg Leu Leu Ala Thr Leu Ser Cys Val Leu Val Leu Leu Lys Trp
    130                 135                 140                 
Asn Val Gly Asp Leu Gln Val Glu Gln Gly Ile Glu Phe Ile Lys Ser
145                 150                 155                 160 
Asn Leu Glu Leu Val Lys Asp Glu Thr Asp Gln Asp Ser Leu Val Thr
                165                 170                 175     
Asp Phe Glu Ile Ile Phe Pro Ser Leu Leu Arg Glu Ala Gln Ser Leu
            180                 185                 190         
Arg Leu Gly Leu Pro Tyr Asp Leu Pro Tyr Ile His Leu Leu Gln Thr
        195                 200                 205             
Lys Arg Gln Glu Arg Leu Ala Lys Leu Ser Arg Glu Glu Ile Tyr Ala
    210                 215                 220                 
Val Pro Ser Pro Leu Leu Tyr Ser Leu Glu Gly Ile Gln Asp Ile Val
225                 230                 235                 240 
Glu Trp Glu Arg Ile Met Glu Val Gln Ser Gln Asp Gly Ser Phe Leu
                245                 250                 255     
Ser Ser Pro Ala Ser Thr Ala Cys Val Phe Met His Thr Gly Asp Ala
            260                 265                 270         
Lys Cys Leu Glu Phe Leu Asn Ser Val Met Ile Lys Phe Gly Asn Phe
        275                 280                 285             
Val Pro Cys Leu Tyr Pro Val Asp Leu Leu Glu Arg Leu Leu Ile Val
    290                 295                 300                 
Asp Asn Ile Val Arg Leu Gly Ile Tyr Arg His Phe Glu Lys Glu Ile
305                 310                 315                 320 
Lys Glu Ala Leu Asp Tyr Val Tyr Arg His Trp Asn Glu Arg Gly Ile
                325                 330                 335     
Gly Trp Gly Arg Leu Asn Pro Ile Ala Asp Leu Glu Thr Thr Ala Leu
            340                 345                 350         
Gly Phe Arg Leu Leu Arg Leu His Arg Tyr Asn Val Ser Pro Ala Ile
        355                 360                 365             
Phe Asp Asn Phe Lys Asp Ala Asn Gly Lys Phe Ile Cys Ser Thr Gly
    370                 375                 380                 
Gln Phe Asn Lys Asp Val Ala Ser Met Leu Asn Leu Tyr Arg Ala Ser
385                 390                 395                 400 
Gln Leu Ala Phe Pro Gly Glu Asn Ile Leu Asp Glu Ala Lys Ser Phe
                405                 410                 415     
Ala Thr Lys Tyr Leu Arg Glu Ala Leu Glu Lys Ser Glu Thr Ser Ser
            420                 425                 430         
Ala Trp Asn Asn Lys Gln Asn Leu Ser Gln Glu Ile Lys Tyr Ala Leu
        435                 440                 445             
Lys Thr Ser Trp His Ala Ser Val Pro Arg Val Glu Ala Lys Arg Tyr
    450                 455                 460                 
Cys Gln Val Tyr Arg Pro Asp Tyr Ala Arg Ile Ala Lys Cys Val Tyr
465                 470                 475                 480 
Lys Leu Pro Tyr Val Asn Asn Glu Lys Phe Leu Glu Leu Gly Lys Leu
                485                 490                 495     
Asp Phe Asn Ile Ile Gln Ser Ile His Gln Glu Glu Met Lys Asn Val
            500                 505                 510         
Thr Ser Trp Phe Arg Asp Ser Gly Leu Pro Leu Phe Thr Phe Ala Arg
        515                 520                 525             
Glu Arg Pro Leu Glu Phe Tyr Phe Leu Val Ala Ala Gly Thr Tyr Glu
    530                 535                 540                 
Pro Gln Tyr Ala Lys Cys Arg Phe Leu Phe Thr Lys Val Ala Cys Leu
545                 550                 555                 560 
Gln Thr Val Leu Asp Asp Met Tyr Asp Thr Tyr Gly Thr Leu Asp Glu
                565                 570                 575     
Leu Lys Leu Phe Thr Glu Ala Val Arg Arg Trp Asp Val Ser Phe Thr
            580                 585                 590         
Glu Asn Leu Pro Asp Tyr Met Lys Leu Cys Tyr Gln Ile Tyr Tyr Asp
        595                 600                 605             
Ile Val His Glu Val Ala Trp Glu Ala Glu Lys Glu Gln Gly Arg Glu
    610                 615                 620                 
Leu Val Ser Phe Phe Arg Lys Gly Trp Glu Asp Tyr Leu Leu Gly Tyr
625                 630                 635                 640 
Tyr Glu Glu Ala Glu Trp Leu Ala Ala Glu Tyr Val Pro Ser Leu Asp
                645                 650                 655     
Glu Tyr Ile Lys Asn Gly Ile Thr Ser Ile Gly Gln Arg Ile Leu Leu
            660                 665                 670         
Leu Ser Gly Val Leu Ile Met Asp Gly Gln Leu Leu Ser Gln Glu Ala
        675                 680                 685             
Leu Glu Lys Val Asp Tyr Pro Gly Arg Arg Val Leu Thr Glu Leu Asn
    690                 695                 700                 
Ser Leu Ile Ser Arg Leu Ala Asp Asp Thr Lys Thr Tyr Lys Ala Glu
705                 710                 715                 720 
Lys Ala Arg Gly Glu Leu Ala Ser Ser Ile Glu Cys Tyr Met Lys Asp
                725                 730                 735     
His Pro Glu Cys Thr Glu Glu Glu Ala Leu Asp His Ile Tyr Ser Ile
            740                 745                 750         
Leu Glu Pro Ala Val Lys Glu Leu Thr Arg Glu Phe Leu Lys Pro Asp
        755                 760                 765             
Asp Val Pro Phe Ala Cys Lys Lys Met Leu Phe Glu Glu Thr Gly Val
    770                 775                 780                 
Thr Met Val Ile Phe Lys Asp Gly Asp Gly Phe Gly Val Ser Lys Leu
785                 790                 795                 800 
Glu Val Lys Asp His Ile Lys Glu Cys Leu Ile Glu Pro Leu Pro Leu
                805                 810                 815     


<210> 360
<211> 555
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> myrcene/ocimene synthase Acc. No. AAG09310

<400> 360
Pro Cys Asn Lys Ser Pro Thr Val Gln Arg Arg Ser Ala Asn Tyr Gln
 1               5                  10                  15      
Pro Ser Arg Trp Asp His His His Leu Leu Ser Val Glu Asn Lys Phe
            20                  25                  30          
Ala Lys Asp Lys Arg Val Arg Glu Arg Asp Leu Leu Lys Glu Lys Val
        35                  40                  45              
Arg Lys Met Leu Asn Asp Glu Gln Lys Thr Tyr Leu Asp Gln Leu Glu
    50                  55                  60                  
Phe Ile Asp Asp Leu Gln Lys Leu Gly Val Ser Tyr His Phe Glu Ala
65                  70                  75                  80  
Glu Ile Asp Asn Ile Leu Thr Ser Ser Tyr Lys Lys Asp Arg Thr Asn
                85                  90                  95      
Ile Gln Glu Ser Asp Leu His Ala Thr Ala Leu Glu Phe Arg Leu Phe
            100                 105                 110         
Arg Gln His Gly Phe Asn Val Ser Glu Asp Val Phe Asp Val Phe Met
        115                 120                 125             
Glu Asn Cys Gly Lys Phe Asp Arg Asp Asp Ile Tyr Gly Leu Ile Ser
    130                 135                 140                 
Leu Tyr Glu Ala Ser Tyr Leu Ser Thr Lys Leu Asp Lys Asn Leu Gln
145                 150                 155                 160 
Ile Phe Ile Arg Pro Phe Ala Thr Gln Gln Leu Arg Asp Phe Val Asp
                165                 170                 175     
Thr His Ser Asn Glu Asp Phe Gly Ser Cys Asp Met Val Glu Ile Val
            180                 185                 190         
Val Gln Ala Leu Asp Met Pro Tyr Tyr Trp Gln Met Arg Arg Leu Ser
        195                 200                 205             
Thr Arg Trp Tyr Ile Asp Val Tyr Gly Lys Arg Gln Asn Tyr Lys Asn
    210                 215                 220                 
Leu Val Val Val Glu Phe Ala Lys Ile Asp Phe Asn Ile Val Gln Ala
225                 230                 235                 240 
Ile His Gln Glu Glu Leu Lys Asn Val Ser Ser Trp Trp Met Glu Thr
                245                 250                 255     
Gly Leu Gly Lys Gln Leu Tyr Phe Ala Arg Asp Arg Ile Val Glu Asn
            260                 265                 270         
Tyr Phe Trp Thr Ile Gly Gln Ile Gln Glu Pro Gln Tyr Gly Tyr Val
        275                 280                 285             
Arg Gln Thr Met Thr Lys Ile Asn Ala Leu Leu Thr Thr Ile Asp Asp
    290                 295                 300                 
Ile Tyr Asp Ile Tyr Gly Thr Leu Glu Glu Leu Gln Leu Phe Thr Val
305                 310                 315                 320 
Ala Phe Glu Asn Trp Asp Ile Asn Arg Leu Asp Glu Leu Pro Glu Tyr
                325                 330                 335     
Met Arg Leu Cys Phe Leu Val Ile Tyr Asn Glu Val Asn Ser Ile Ala
            340                 345                 350         
Cys Glu Ile Leu Arg Thr Lys Asn Ile Asn Val Ile Pro Phe Leu Lys
        355                 360                 365             
Lys Ser Trp Thr Asp Val Ser Lys Ala Tyr Leu Val Glu Ala Lys Trp
    370                 375                 380                 
Tyr Lys Ser Gly His Lys Pro Asn Leu Glu Glu Tyr Met Gln Asn Ala
385                 390                 395                 400 
Arg Ile Ser Ile Ser Ser Pro Thr Ile Phe Val His Phe Tyr Cys Val
                405                 410                 415     
Phe Ser Asp Gln Leu Ser Ile Gln Val Leu Glu Thr Leu Ser Gln His
            420                 425                 430         
Gln Gln Asn Val Val Arg Cys Ser Ser Ser Val Phe Arg Leu Ala Asn
        435                 440                 445             
Asp Leu Val Thr Ser Pro Asp Glu Leu Ala Arg Gly Asp Val Cys Lys
    450                 455                 460                 
Ser Ile Gln Cys Tyr Met Ser Glu Thr Gly Ala Ser Glu Asp Lys Ala
465                 470                 475                 480 
Arg Ser His Val Arg Gln Met Ile Asn Asp Leu Trp Asp Glu Met Asn
                485                 490                 495     
Tyr Glu Lys Met Ala His Ser Ser Ser Ile Leu His His Asp Phe Met
            500                 505                 510         
Glu Thr Val Ile Asn Leu Ala Arg Met Ser Gln Cys Met Tyr Gln Tyr
        515                 520                 525             
Gly Asp Gly His Gly Ser Pro Glu Lys Ala Lys Ile Val Asp Arg Val
    530                 535                 540                 
Met Ser Leu Leu Phe Asn Pro Ile Pro Leu Asp
545                 550                 555 


<210> 361
<211> 530
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> synthase Acc. No. AAC64880

<400> 361
Met Gln Glu Leu Ile Asn Thr Leu Ser Ala Leu Thr Thr Glu Glu Ile
 1               5                  10                  15      
Tyr Arg Pro Leu Ala Asp Phe Pro Val Asn Ile Trp Glu Asp Pro Leu
            20                  25                  30          
Ile Ser Phe Ser Val Leu Asp Pro Glu Ser Glu Ile Asn Glu Glu Lys
        35                  40                  45              
Leu Ser Ser Leu Lys Glu Thr Val Arg Gly Leu Leu Met Ala Ser Lys
    50                  55                  60                  
Glu Glu Pro Ile Glu Asn Ile Lys Phe Ile Asp Ala Leu Cys Arg Leu
65                  70                  75                  80  
Gly Val Ser Tyr His Phe Glu Val Asp Ile Phe Thr Gln Leu Glu Thr
                85                  90                  95      
Met Phe Gly Val Met Met Ile Arg Gly Asn Glu Phe Asp Leu Tyr Thr
            100                 105                 110         
Val Ser Leu Val Phe Gln Ile Phe Arg Gln Phe Gly Tyr Lys Leu Gly
        115                 120                 125             
Val Asp Val Phe Asn Asn Phe Lys Asn Lys Asp Gly Lys Phe Lys Glu
    130                 135                 140                 
His Leu Ala Glu Asp Ala Arg Gly Leu Leu Cys Leu Tyr Glu Ala Ala
145                 150                 155                 160 
His Trp Ser Thr His Gly Glu Asp Ile Leu Asp Glu Ala Leu Ala Phe
                165                 170                 175     
Ser Arg Ser His Leu Glu Gly Leu Ala Asp Gln Ser Ser Pro Pro Met
            180                 185                 190         
Ser Ile Arg Ile Lys Asn Ala Leu Lys His Ala Tyr Pro Arg Gly Ile
        195                 200                 205             
Ser Arg Ile Glu Thr Arg Gln Tyr Ile Ser Tyr Tyr Glu Glu Glu Asp
    210                 215                 220                 
Leu His Asp Gln Thr Leu Leu Glu Phe Ala Lys Ile Asp Phe Asn Leu
225                 230                 235                 240 
Leu Gln Ile Leu His Arg Lys Glu Leu Cys Gln Val Phe Arg Trp Tyr
                245                 250                 255     
Ser Asn Leu Glu Leu Asp Leu Lys Val Pro Tyr Ala Arg Asn Arg Thr
            260                 265                 270         
Val Glu Ser Tyr Leu Trp Ala Val Gly Ala Tyr Phe Glu Pro Arg Tyr
        275                 280                 285             
Ser Gln Ala Arg Ile Arg Leu Ala Ile Val Val Ile Leu Leu Thr Leu
    290                 295                 300                 
Val Asp Asp Thr Gly Ile Glu Gly Leu Pro Glu Ser Met Arg Tyr Leu
305                 310                 315                 320 
His His Val Val Leu Asp Phe Tyr Gly Lys Leu Glu Glu Asp Met Glu
                325                 330                 335     
Arg Glu Gly Arg Ser Gly Cys Gly Leu Phe Ala Lys Lys Ser Met Ile
            340                 345                 350         
Val Thr Ala Lys Ala Tyr Leu Gln Glu Ala Lys Trp Leu Ser Glu Asp
        355                 360                 365             
Phe Val Ala Thr Phe Asp Glu Tyr Lys Glu Asn Gly Val Tyr Ser Ser
    370                 375                 380                 
Ser Tyr Leu Ala Leu Leu Thr Gly Ser Phe Leu Gly Met Val Asp Glu
385                 390                 395                 400 
Gly Thr Leu Asp Val Phe Glu Trp Leu Ser Thr Phe Pro Pro Leu Leu
                405                 410                 415     
Val Thr Ser Ala Leu Ile Gly Arg Leu Cys Gly Asp Ile Ala Ser Cys
            420                 425                 430         
Glu Phe Glu His Lys Arg Lys His Val Gly Thr Ser Ile Asp Cys Tyr
        435                 440                 445             
Met Lys Gln Tyr Gly Ile Ser Trp Glu Lys Ala Glu Glu Glu Ile Lys
    450                 455                 460                 
Ile Met Ala Leu Asp Ser Trp Lys Ser Leu Asn Gln Glu Leu Met Thr
465                 470                 475                 480 
Arg Asp His Ser Phe Ala Phe Pro Ile Val Met Arg Phe Leu Asn Leu
                485                 490                 495     
Ser Arg Val Val Lys Val Leu Tyr Lys Asp Thr Asp Ile Phe Thr His
            500                 505                 510         
Pro Glu Leu Met Lys His His Val Val Ser Leu Phe Leu Asn Arg Ile
        515                 520                 525             
Ser Ile
    530 


<210> 362
<211> 632
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> synthase Acc. No. AAB61105

<400> 362
Met Glu Ala Ile Thr Lys Tyr Gly Ser Tyr Phe Asn Val Arg Phe Leu
 1               5                  10                  15      
Ser Arg Leu Cys Trp Arg Leu Asn Leu Ser Ser Ser Tyr His Tyr Pro
            20                  25                  30          
Leu Leu Lys Ser Ser Leu Ser Phe Ser Arg Phe Gln Ser Pro Lys Lys
        35                  40                  45              
Leu Cys Leu Val Arg Ala Thr Thr Asn Pro Thr Asp Asp Asn Ser Thr
    50                  55                  60                  
Thr Arg Ser Phe Thr Pro His Pro Pro Ser Leu Trp Gly His His Phe
65                  70                  75                  80  
Leu Ser Ala Ser Val Asn Gln Thr Glu Met Asp Asp Leu Trp Arg Gln
                85                  90                  95      
Ile Glu Ala Leu Lys Pro Ile Val Asn Ala Met Leu Leu Pro Cys Asn
            100                 105                 110         
Gly Ala Asp Ala Lys Lys Ile Thr Cys Phe Ile His Thr Leu Val Ser
        115                 120                 125             
Leu Gly Val Ser Tyr His Phe Glu Glu Lys Ile Val Glu Phe Leu Lys
    130                 135                 140                 
Asp Ala Phe Glu Asn Ile Glu Asp Met Ile Ile Asp Cys Lys Glu Asp
145                 150                 155                 160 
Asp Leu Tyr Thr Val Ser Ile Ile Phe Arg Val Phe Arg Leu Tyr Gly
                165                 170                 175     
His Tyr Ile Thr Pro Glu Leu His Ile Thr Ile Ser Tyr Tyr Phe Phe
            180                 185                 190         
Phe Leu Ile Phe His Thr Cys Met Cys Val Asp Ile Phe Asn Arg Phe
        195                 200                 205             
Lys Gly Asp Asp Gly Asn Phe Lys Lys Cys Leu Asn Asp Asp Val Arg
    210                 215                 220                 
Gly Met Leu Ser Phe Tyr Glu Ala Ser His Phe Gly Thr Thr Thr Glu
225                 230                 235                 240 
Asp Ile Leu Glu Glu Ala Met Ser Phe Thr Gln Lys His Leu Glu Leu
                245                 250                 255     
Phe Leu Val Gly Glu Lys Ala Lys His Tyr Pro His Ile Thr Lys Leu
            260                 265                 270         
Ile Gln Ala Ala Leu Tyr Ile Pro Gln Asn Phe Asn Leu Glu Ile Leu
        275                 280                 285             
Val Ala Arg Glu Tyr Ile Asp Phe Tyr Glu Leu Glu Thr Asp His Asn
    290                 295                 300                 
Glu Met Leu Leu Lys Leu Ala Lys Leu Asn Phe Arg Phe Leu Gln Leu
305                 310                 315                 320 
Gln Tyr Ile Gln Asp Leu Lys Thr Leu Thr Thr Trp Trp Lys Glu Leu
                325                 330                 335     
Asp Leu Val Ser Lys Ile Pro Val Tyr Phe Arg Glu Arg Leu Ala Glu
            340                 345                 350         
Pro Tyr Phe Trp Ala Thr Gly Ile Tyr Tyr Glu Pro Gln Tyr Ser Ala
        355                 360                 365             
Ala Arg Ile Met Leu Ala Lys Ser Ile Ile Leu Val Asp Ile Val Asp
    370                 375                 380                 
Asn Thr Phe Asp Val Tyr Gly Thr Ile Asp Glu Val Lys Ser Leu Val
385                 390                 395                 400 
Gln Ala Ile Glu Arg Trp Asp Ser Asp Ala Val Asp Val Leu Pro Asp
                405                 410                 415     
Tyr Leu Lys Val Val Phe Arg Thr Thr Phe Asp Leu Phe Lys Glu Leu
            420                 425                 430         
Glu Glu Tyr Val Ser Ser Glu Ala Arg Ser Phe Thr Met Gln Tyr Ala
        435                 440                 445             
Tyr Glu Gln Leu Arg Ile Leu Met Lys Gly Tyr Leu Gln Glu Ala Glu
    450                 455                 460                 
Trp Ser Asn Arg Gly His Leu Pro Ser His Glu Glu Tyr Ile Glu Val
465                 470                 475                 480 
Gly Val Ala Ser Thr Ala Gly Glu Val Leu Leu Ala Met Thr Phe Ile
                485                 490                 495     
Pro Met Gly Asp Ala Ala Gly Val Gly Val Tyr Glu Trp Leu Arg Ser
            500                 505                 510         
Arg Pro Lys Leu Thr His Ala Leu Phe Val Lys Ser Arg Leu Arg Asp
        515                 520                 525             
Asp Ile Ala Thr Tyr Lys Glu Glu Met Lys Arg Gly Asp Val Cys Asn
    530                 535                 540                 
Gly Ile Asn Cys Tyr Thr Lys Gln His Lys Val Ser Glu Glu Glu Ala
545                 550                 555                 560 
Cys Ile Glu Phe Glu Lys Lys Thr Asn His Met Ser Lys Val Met Asn
                565                 570                 575     
Glu Glu Phe Leu Lys Ala Ala Lys Phe Ile Pro Leu His Ile Leu Arg
            580                 585                 590         
Pro Val Leu Asn Tyr Gly Arg Leu Ala Asp Val Cys Tyr Lys Tyr Gly
        595                 600                 605             
Asp Gly Tyr Thr Phe Ala Gly Glu Lys Ile Lys Asp Tyr Ile Thr Ser
    610                 615                 620                 
Leu Tyr Val Asp Leu Ile Thr Leu
625                 630         


<210> 363
<211> 599
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> terpene cyclase TC1 Acc. No. CAA72070

<400> 363
Met Tyr Ser Ile Ser Leu Val Val Asn Met Gln Cys Ile Ser Ala Tyr
 1               5                  10                  15      
Gly Ser Ile Leu Ser Leu Pro Leu Arg Ser Asn Leu Phe Ser Val Arg
            20                  25                  30          
Lys Leu Ser Ser Phe Pro His Lys Ser Phe Ser Gly Gln His Gly Lys
        35                  40                  45              
Leu Val Arg Met Lys Ala Thr Pro Thr Arg Ala Cys His Asp Gln Glu
    50                  55                  60                  
Ser Asn Arg Lys Phe Lys Arg Leu Pro Leu Ser Lys Trp Gly His His
65                  70                  75                  80  
Phe Leu Ser Ala Gln Val Asp Val Ser Glu Met Asn Ala Leu Ala Gln
                85                  90                  95      
Glu Ile Glu Arg Leu Lys Pro Glu Val Gly Glu Met Leu Met Phe Ser
            100                 105                 110         
Ser Lys Ser Ile Glu Ser Thr Lys Lys Arg Ile Leu Phe Ile Tyr Met
        115                 120                 125             
Leu Val Ser Leu Gly Val Ala Phe His Phe Glu Asp Glu Ile Glu Gln
    130                 135                 140                 
Ser Leu Glu Glu Gly Phe Glu Lys Ile Gln Glu Met Ile Ala Gly Glu
145                 150                 155                 160 
Asp Asp Leu Tyr Thr Ile Ser Ile Met Phe Trp Val Phe Arg Thr Tyr
                165                 170                 175     
Gly Tyr Asn Met Ser Thr Gly Asp Val Phe Lys Arg Phe Lys Gly Glu
            180                 185                 190         
Asn Glu Lys Phe Met Glu Ser Ile Thr Ser Asp Val Lys Gly Met Val
        195                 200                 205             
Ser Leu Tyr Glu Ala Ala His Leu Arg Thr Thr Arg Glu Asp Ile Leu
    210                 215                 220                 
Glu Glu Ala Leu Ser Phe Thr Thr Arg Asn Leu Glu Ser Leu Ala Arg
225                 230                 235                 240 
Ala Gly Ala Ser Ser Pro His Ile Leu Met Arg Ile Arg Asn Ala Leu
                245                 250                 255     
Cys Met Pro Gln His Tyr Asn Ala Glu Met Ile Phe Ala Arg Glu Tyr
            260                 265                 270         
Ile Ser Phe Tyr Glu Gln Glu Glu Asp His Asn Lys Met Leu Leu Arg
        275                 280                 285             
Phe Ala Lys Ile Asn Phe Lys Phe Leu Gln Leu Asn Trp Ile Gln Glu
    290                 295                 300                 
Leu Lys Thr Leu Thr Lys Trp Trp Lys Gln Gln Asp Leu Ala Ser Lys
305                 310                 315                 320 
Leu Pro Pro Tyr Phe Arg Asp Arg Leu Ile Glu Cys Tyr Leu Phe Ala
                325                 330                 335     
Ile Met Ile Tyr Phe Glu Pro Gln Phe Ser Leu Gly Arg Val Ser Leu
            340                 345                 350         
Ala Lys Ile Asn Thr Val Phe Thr Leu Val Asp Asp Thr Cys Asp Arg
        355                 360                 365             
Tyr Gly Asn Val Ser Glu Val Ala Ala Leu Val Gln Cys Val Glu Arg
    370                 375                 380                 
Trp Asp Pro Asp Cys Met Asp Ser Leu Pro Asp Tyr Met Lys Thr Val
385                 390                 395                 400 
Phe Lys Phe Ala Trp Asn Thr Phe Glu Glu Cys Glu Asn Ala Gly Ile
                405                 410                 415     
Met Glu Glu Gly Leu Ser Tyr Asp Val Gln Gly Ala Leu Glu Glu Trp
            420                 425                 430         
Glu Gln Gly Asp Val Val Pro Thr Phe Asp Glu Tyr Leu Glu Ile Gly
        435                 440                 445             
Gly Val Glu Val Thr Met Tyr Val Ser Ile Ala Cys Ser Phe Leu Gly
    450                 455                 460                 
Leu Gly Gln Ser Ser Arg Glu Gln Ala Tyr Lys Trp Leu Lys Ser Arg
465                 470                 475                 480 
Pro Lys Phe Val Glu Ala Gln Ala Lys Arg Ala Arg Leu Met Asn Asp
                485                 490                 495     
Ile Ala Gly Phe Glu Gly Asp Met Ser Arg Gly Phe Asp Val Asn Ala
            500                 505                 510         
Ile Met Tyr Tyr Met Lys Gln Tyr Lys Val Thr Glu Glu Glu Thr Phe
        515                 520                 525             
Thr Arg Leu Gln Lys Met Ala Arg Asp Leu Asp Thr Thr Val Asn Glu
    530                 535                 540                 
Glu Ile Leu Lys Thr Thr Lys Ser Val Pro Arg Gln Ile Leu Lys Arg
545                 550                 555                 560 
Ala Ile Asp Phe Gly Lys Met Ile Glu Phe Thr Tyr Arg Ser Gly Glu
                565                 570                 575     
Glu Tyr Thr His Pro Glu Gly Arg Phe Lys Asp His Ile Thr Ser Leu
            580                 585                 590         
Phe Val Asp Leu Ile Arg Leu
        595                 


<210> 364
<211> 603
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein Acc. No.
      NP_174635

<400> 364
Met Glu Ala Ala Arg Met Gly Phe Arg Ala Lys Thr Leu Pro His Leu
 1               5                  10                  15      
Gly Asn Gly Thr Arg Leu Pro Leu Lys Thr Lys Leu Ser Leu Phe Pro
            20                  25                  30          
Met His Leu Leu Gln Asn His Thr Thr Leu Ser Arg Arg Ser Thr Lys
        35                  40                  45              
Leu Asn Leu Cys Val Lys Ala Cys Ser Lys Thr Ser Gly Val Glu Ser
    50                  55                  60                  
Ser Arg Pro Leu Pro His Ser Ala Pro Asp Leu Trp Gly Asp His Ile
65                  70                  75                  80  
Leu Ser Val Pro Thr Glu Asn Ser Glu Phe Asp Thr Leu Glu Thr Glu
                85                  90                  95      
Ile Glu Ser Ile Lys Pro Lys Val Arg Asn Met Leu Met Ser Ser His
            100                 105                 110         
Lys Thr Asp Lys Glu Arg Ile Cys Leu Ile His Leu Leu Ile Cys Leu
        115                 120                 125             
Gly Thr Phe His Tyr Phe Glu Lys Glu Ile Glu Glu Ile Leu Glu Gln
    130                 135                 140                 
Ala Phe Arg Lys Leu Asp Met Leu Phe Thr Asp Glu Asp Asp Leu Glu
145                 150                 155                 160 
Thr Thr Ala Ile Met Phe Glu Val Phe Arg Leu Tyr Gly His Lys Ile
                165                 170                 175     
Ser Cys Asp Val Phe Asp Arg Phe Lys Gly Val Asp Ala Lys Phe Lys
            180                 185                 190         
Glu His Leu Val Ser Asp Val Arg Gly Met Leu Gln Leu Tyr Glu Ala
        195                 200                 205             
Ala His Leu Ala Thr Pro Phe Glu Thr Ile Leu Asp Glu Ala Leu Ser
    210                 215                 220                 
Phe Thr Arg Tyr His Leu Glu Ser Leu Ala Gly Gln Gln Ala Thr Ala
225                 230                 235                 240 
Pro His Ile Ser Arg His Ile Leu Asn Ala Leu Tyr Lys Pro Arg Phe
                245                 250                 255     
Leu Lys Met Glu Ile Ile Ala Ala Arg Glu Tyr Ile His Phe Tyr Gln
            260                 265                 270         
Lys Glu Gly His Asp Glu Thr Leu Leu Lys Phe Ala Lys Leu Asn Phe
        275                 280                 285             
Asn Phe Cys Gln Leu His Tyr Val Arg Glu Leu Lys Thr Leu Thr Lys
    290                 295                 300                 
Trp Trp Lys Asp Ile Asp Leu Pro Tyr Lys Leu Pro Tyr Ile Arg Asp
305                 310                 315                 320 
Arg Leu Leu Glu Thr Phe Ile Gly Val Met Ala Val Tyr Leu Glu Pro
                325                 330                 335     
His Tyr Ser Leu Gly Arg Ile Ile Ala Thr Lys Val Ser Gln Val Ile
            340                 345                 350         
Val Val Met Asp Asp Thr Cys Asp Ala Tyr Gly Thr Phe Ser Glu Val
        355                 360                 365             
Arg Ser Leu Ile Asp Ser Leu Glu Arg Trp Asp Pro Gly Ala Ile Asp
    370                 375                 380                 
Lys Leu Pro Ser Cys Leu Arg Ile Val Ile Gln Ser Ile Val Glu Thr
385                 390                 395                 400 
Met Glu Asp Ile Glu Arg Glu Met Lys Pro Arg Gly Arg Ser Ser Ser
                405                 410                 415     
Val Gln Asp Thr Val Glu Glu Ile Lys Ile Met Gly Arg Ala Tyr Ala
            420                 425                 430         
Glu Ile Ser Lys Trp Ala Arg Ala Gly His Val Pro Thr Phe Asp Asp
        435                 440                 445             
Tyr Ile Glu Leu Gly Leu Asp Ser Ser Gly Ile Arg Cys Phe Ala Met
    450                 455                 460                 
Tyr Ser Phe Ile Ser Met Glu Asp Cys Glu Glu Asn Gln Thr Asn Ala
465                 470                 475                 480 
Trp Phe Lys Ser Lys Pro Lys Met Leu Arg Ala Leu Ser Val Ile Phe
                485                 490                 495     
Arg Leu Thr Asn Asp Ile Ala Gly Phe Glu Glu Glu Met Arg Arg Gly
            500                 505                 510         
Glu Val Val Asn Gly Val Asn Cys Tyr Val Lys Gln His Asn Val Thr
        515                 520                 525             
Lys Glu Leu Ala Val Arg Glu Ile Lys Lys Met Ile Arg Asp Asn Tyr
    530                 535                 540                 
Lys Ile Met Met Glu Glu Phe Leu Thr Ile Lys Ser Val Ser Arg Pro
545                 550                 555                 560 
Ile Leu Val Arg Cys Phe Asn Ile Val Arg Leu Val Asn Leu Tyr Tyr
                565                 570                 575     
Glu Glu Gly Asp Asn Phe Thr Asn Pro Asn Gly Lys Leu Lys Asp Leu
            580                 585                 590         
Ile Thr Ser Leu Phe Phe His Pro Leu Pro Leu
        595                 600             


<210> 365
<211> 603
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein Acc. No.
      NP_175312

<400> 365
Met Glu Ala Ile Arg Val Phe Gly Pro Lys Leu Gly Ser Arg Leu Ser
 1               5                  10                  15      
Ile Arg Ser His Thr Thr Ala Phe Pro Ala Cys Lys Leu Ser Arg Phe
            20                  25                  30          
Pro Leu Thr Ser Phe Pro Gly Lys His Ala His Leu Val Leu Leu Lys
        35                  40                  45              
Ala Thr Thr Ile Pro Leu Ala Ser Gly Asp Lys Glu Asn Asn Arg Lys
    50                  55                  60                  
Phe Glu Lys Leu Gly Pro Ser Glu Trp Gly Asn Gln Phe Leu Phe Ala
65                  70                  75                  80  
His Val Asp Leu Ser Glu Met Asp Ala Leu Glu Arg Glu Ile Glu Ala
                85                  90                  95      
Leu Lys Pro Lys Val Arg Asp Met Phe Met Ser Phe Lys Gly Met Lys
            100                 105                 110         
Ser Asn Lys Lys Asn Leu Phe Leu Ile Tyr Leu Leu Val Ser Leu Gly
        115                 120                 125             
Leu Ala His His Phe Glu Asp Glu Ile Glu Glu Ser Val Lys Gly Cys
    130                 135                 140                 
Ser Gln Glu Met Val Glu Met Met Asp Gly Glu Asn Asp Leu Tyr Thr
145                 150                 155                 160 
Val Ser Ile Ile Phe Trp Val Phe Arg Thr Tyr Gly His Asn Ile Ser
                165                 170                 175     
Ser Asp Ile Phe Asn Arg Phe Lys Gly His Asn Gly Lys Phe Lys Glu
            180                 185                 190         
Cys Leu Ala Thr Asp Ala Lys Gly Ile Leu Ser Leu Tyr Glu Ala Ala
        195                 200                 205             
His Met Gly Thr Thr Thr Asp Tyr Ile Leu Asp Glu Ala Leu Ser Phe
    210                 215                 220                 
Thr Leu Ser Tyr Leu Glu Ser Leu Ala Ala Asn Gly Thr Cys Lys Pro
225                 230                 235                 240 
Asn Leu Val Arg Arg Ile Arg Asn Ala Leu Gly Leu Leu Gln Asn Lys
                245                 250                 255     
Asn Val Glu Ile Leu Val Ala Lys Glu Tyr Ile Arg Phe Tyr Glu Gln
            260                 265                 270         
Glu Glu Asp Cys Asp Lys Thr Ile Leu Glu Phe Ser Met Leu Asn Leu
        275                 280                 285             
Lys Phe Leu Gln Leu His Tyr Leu Gln Glu Leu Lys Leu Leu Thr Lys
    290                 295                 300                 
Trp Tyr Lys Glu Gln Asp Phe Glu Ser Lys Leu Pro Pro Tyr Tyr Arg
305                 310                 315                 320 
Asp Arg Ile Val Glu Leu His Leu Ala Thr Leu Ala Tyr Ile Asn Pro
                325                 330                 335     
Lys Tyr Ser Arg Val Arg Ile Ile Leu Thr Met Ile Tyr Thr Ile Gln
            340                 345                 350         
Ile Ile Leu Asp Asp Thr Cys Asp Arg Tyr Ala Ser Leu Arg Glu Val
        355                 360                 365             
Glu Ser Leu Ala Ala Thr Ile Glu Arg Trp Asp His Asn Asp His Ala
    370                 375                 380                 
Met Glu Gly Leu Pro Asp Tyr Leu Lys Ser Val Ala Lys Phe Ile Phe
385                 390                 395                 400 
His Thr Phe Gln Glu Phe Glu Arg Glu Val Ser Ser Glu Ser Gly Gly
                405                 410                 415     
Ser Tyr Ser Leu Lys Ala Thr Ile Glu Asp Cys Lys Arg Met Met Arg
            420                 425                 430         
Ser Asn Leu Gln Leu Ala Lys Trp Ala Val Thr Gly His Leu Pro Ser
        435                 440                 445             
Phe Asp Glu Tyr Leu Asp Val Ala Gly Val Glu Ile Ala Val Tyr Phe
    450                 455                 460                 
Thr Val Ala Gly Ile Leu Leu Gly Met Glu Asn Ile Asn Lys Lys Glu
465                 470                 475                 480 
Ala Tyr Glu Trp Leu Ile Phe Arg Asp Lys Leu Val Arg Ala Met Ser
                485                 490                 495     
Thr Lys Ala Arg Leu Val Asn Asp Leu Phe Gly Tyr Lys Asp Asp Met
            500                 505                 510         
Arg Arg Gly Tyr Val Thr Asn Ser Ile Asn Cys Tyr Lys Lys Gln Tyr
        515                 520                 525             
Gly Val Thr Glu Glu Glu Ala Phe Arg Lys Leu His Gln Met Val Ala
    530                 535                 540                 
Asp Gly Asp Lys Met Met Asn Glu Glu Phe Leu Lys Pro Ile Asn Val
545                 550                 555                 560 
Pro His Gln Val Leu Lys Ala Val Leu Asp Thr Leu Arg Ala Ile Asn
                565                 570                 575     
Ile Cys Tyr Asp Asn Glu Asp Gly Phe Thr Arg Leu Asn Gly Asn Leu
            580                 585                 590         
Lys Asn Tyr Ile Thr Ser Met Tyr Val Asp Leu
        595                 600             


<210> 366
<211> 601
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein Acc. No.
      NP_188067

<400> 366
Met Glu Ala Thr Arg Thr Ser Phe Gly Leu His Asn Ala Pro Leu Cys
 1               5                  10                  15      
Pro Thr Thr Asn Pro Ser Leu Phe Pro Arg Arg Trp Leu His Lys His
            20                  25                  30          
Thr Leu Ser Leu Lys Pro Ala Lys Gln His His Leu Val Cys Val Arg
        35                  40                  45              
Ala Thr Glu Ser Asn Asp Asn Leu Glu Ser Ser Arg Pro Leu Ala His
    50                  55                  60                  
Phe Ser Pro Thr Leu Trp Gly Asp His Phe Leu Ser Val Pro Leu His
65                  70                  75                  80  
Val Ala Glu Phe Asp Asp Phe Ser Arg Glu Ile Glu Val Thr Met Lys
                85                  90                  95      
Pro Lys Val Arg Asp Met Leu Lys Ser Ser Lys Asn Ser Asp Asn Glu
            100                 105                 110         
Arg Ile Arg Leu Ile His Leu Leu Met Asn Leu Gly Ile Ala Tyr His
        115                 120                 125             
Phe Glu Ile Glu Ile Asp Glu Ile Leu Gly Gln Ala Phe Gly Asn Leu
    130                 135                 140                 
Asp Asp Ile Ile Ala Lys Glu Asn Asp Leu Glu Thr Ile Ser Thr Met
145                 150                 155                 160 
Phe Glu Val Phe Arg Leu Arg Gly Tyr Tyr Met Pro Cys Tyr Ala Phe
                165                 170                 175     
Asn Arg Phe Lys Gly Glu Asp Gly Arg Phe Lys Glu Ser Leu Ala Glu
            180                 185                 190         
Asp Ile Arg Gly Met Leu Gln Leu Tyr Glu Ala Ala His Leu Gly Thr
        195                 200                 205             
Pro Ser Glu Asp Ile Met Asp Glu Ala Leu Ser Phe Thr Arg Tyr Arg
    210                 215                 220                 
Leu Glu Ser Leu Thr Ser Asn His Thr Ala Thr Ala Ser Pro His Leu
225                 230                 235                 240 
Ser Lys His Ile Gln Asn Ala Leu Tyr Arg Ala Arg Tyr His Asn Leu
                245                 250                 255     
Glu Ile Leu Val Ala Arg Glu Tyr Ile Ser Phe Tyr Glu Gln Glu Glu
            260                 265                 270         
Asp His Asp Glu Thr Leu Leu Lys Phe Ala Lys Leu Asn Phe Asn Tyr
        275                 280                 285             
Cys Gln Leu His Tyr Ile Gln Glu Leu Lys Asp Leu Thr Lys Trp Trp
    290                 295                 300                 
Lys Glu Leu Asp Leu Ala Ser Lys Leu Pro Tyr Ile Arg Asp Arg Ile
305                 310                 315                 320 
Val Glu Val Tyr Phe Gly Ala Leu Ala Leu Tyr Phe Glu Pro Arg Tyr
                325                 330                 335     
Ser Leu Gly Arg Ile Ile Val Thr Lys Ile Thr Met Ile Val Thr Val
            340                 345                 350         
Phe Asn Asp Thr Cys Asp Ala Tyr Gly Thr Leu Pro Glu Val Thr Ser
        355                 360                 365             
Leu Val Asp Ser Phe Gln Arg Trp Asp Leu Gly Asp Ile Glu Lys Leu
    370                 375                 380                 
Pro Ser Tyr Val Lys Ile Val Phe Arg Gly Val Phe Glu Thr Leu Glu
385                 390                 395                 400 
Glu Ile Glu Gln Glu Met Arg Pro Gln Gly Arg Ser Arg Ile Val Gln
                405                 410                 415     
Val Ala Val Asp Glu Ile Lys Lys Leu Gly Lys Ala Tyr Leu Ala Ile
            420                 425                 430         
Ser Lys Trp Ala Arg Ala Ser His Val Pro Thr Phe Glu Glu Tyr Met
        435                 440                 445             
Glu Phe Gly Met Gln Thr Ser Met Asp His Phe Ala Ala Tyr Ser Phe
    450                 455                 460                 
Ile Ala Met Glu Asp Cys Asp Glu Asn Gln Thr Cys Glu Trp Tyr Lys
465                 470                 475                 480 
Ser Arg Pro Lys Met Met Glu Ala Leu Asn Gly Val Phe Arg Ile Lys
                485                 490                 495     
Asn Asp Ile Asn Thr Phe Glu Gln Glu Met Ser Arg Gly Glu Val Ala
            500                 505                 510         
Lys Gly Leu Asn Cys Tyr Met Lys Gln His Gly Val Ser Lys Glu Glu
        515                 520                 525             
Ala Ile Gly Glu Met Asn Lys Ile Tyr Ser Asn Tyr Tyr Lys Ile Ile
    530                 535                 540                 
Met Glu Glu Tyr Leu Thr Thr Thr Ala Val Pro Arg Pro Ile Leu Val
545                 550                 555                 560 
Arg Cys Leu Asn Val Ser Arg Pro Ile His His Phe Tyr Lys Glu Arg
                565                 570                 575     
Asp Glu Phe Thr Asp Pro Tyr Phe Gly Met Leu Lys Glu Val Ile Thr
            580                 585                 590         
Ser Leu Phe Ile His Pro Ile Pro Leu
        595                 600     


<210> 367
<211> 604
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein Acc. No.
      NP_189746

<400> 367
Met Ala Val Ala Arg Thr Val Phe Gly Leu Gly Thr Leu Ser Tyr Leu
 1               5                  10                  15      
His Gln Ala Pro Leu Phe Leu Lys Thr Ser Gln Ser Leu Phe Pro Arg
            20                  25                  30          
Pro Ser Leu Ser Leu Lys Pro Met Lys His Asp Phe Val Cys Val Lys
        35                  40                  45              
Ala Thr Thr Lys Ser Ser Thr Ser Asp Asp Leu Glu Ser Gly Arg Pro
    50                  55                  60                  
Ser Ile Leu Phe Ser Pro Ser Ile Trp Gly Asp Tyr Phe Leu Ser Val
65                  70                  75                  80  
Ser Val Asp Asp Ser Glu Phe Asp Asp Ile Ala Arg Glu Ile Glu Ser
                85                  90                  95      
Val Met Lys Pro Tyr Val Arg Asp Arg Leu Ile Ser Ser His Asn Ser
            100                 105                 110         
Asn Lys Asp Lys Ile Arg Leu Ile His Leu Leu Ile Ser Leu Gly Ile
        115                 120                 125             
Ser Tyr Tyr Phe Glu Ser Glu Ile Glu Met Ile Leu Asn Lys Ala Phe
    130                 135                 140                 
Glu Glu Leu Asp Met Ile Ile Ala Glu Glu Asp Asp Leu Glu Thr Ile
145                 150                 155                 160 
Ser Ile Met Phe Glu Val Phe Arg Leu Tyr Gln His Lys Met Ser Cys
                165                 170                 175     
Asp Ser Phe Val Arg Phe Lys Gly Glu Asp Gly Arg Leu Lys Glu Ser
            180                 185                 190         
Leu Val Gly Asp Val Arg Gly Met Leu Gln Leu Tyr Gln Ala Ala His
        195                 200                 205             
Leu Gly Thr Pro Ser Asp Gln Tyr Ile Met Glu Glu Ala Lys Ser Phe
    210                 215                 220                 
Thr Arg Asn His Leu Glu Ser Leu Val Glu Ser Thr Thr Ile Pro Pro
225                 230                 235                 240 
His Phe Ser Ser His Ile Arg Asp Ala Leu Tyr Ile Asp Arg Tyr His
                245                 250                 255     
Asn Met Glu Ile Leu Val Ala Arg Lys Tyr Ile Ser Phe Tyr Glu Gln
            260                 265                 270         
Glu Glu Gly His Asp Leu Thr Leu Leu Lys Phe Gly Lys Leu Ser Phe
        275                 280                 285             
Asn Tyr Cys Arg Leu His Tyr Ile Gln Glu Leu Lys Thr Leu Thr Lys
    290                 295                 300                 
Trp Trp Lys Asp Gln Asp Ile Pro Ser Asn Leu Pro Cys Val Arg Asp
305                 310                 315                 320 
Arg Ile Val Glu Thr Tyr Phe Pro Thr Leu Gly Leu Tyr Phe Glu Pro
                325                 330                 335     
Arg Phe Ser Leu Gly Arg Ile Ile Ile Ala Lys Met Thr Ile Ile Val
            340                 345                 350         
Val Ala Leu Asn Asp Val Cys Asp Ser Tyr Ala Thr Tyr Pro Glu Ala
        355                 360                 365             
Lys Ser Leu Ile Asp Ser Leu Gln Arg Trp Asp Ile Glu Ala Ile Asp
    370                 375                 380                 
Glu Leu Pro Asn Tyr Ser Arg Ile Val Leu Arg Leu Ile Leu Glu Thr
385                 390                 395                 400 
Ile Gly Glu Ile Glu Arg Glu Met Lys Pro Arg Gly Arg Ser Ala Ser
                405                 410                 415     
Val Gln His Thr Ile Asp Glu Thr Lys Ser Leu Gly Arg Ala Tyr Leu
            420                 425                 430         
Ala Leu Ser Lys Trp Ala Ser Glu Gly Tyr Met Pro Thr Phe Asp Glu
        435                 440                 445             
Tyr Met Glu Val Gly Glu Val Thr Gly Gly Met Asp Asp Phe Ala Leu
    450                 455                 460                 
Tyr Ser Phe Ile Ala Met Glu Asp Cys Asp Glu Lys Pro Leu Tyr Glu
465                 470                 475                 480 
Trp Phe Asp Ser Lys Pro Lys Ile Leu Gln Ala Leu Ser Val Leu Tyr
                485                 490                 495     
Arg Ile Asn Asn Asp Ile Val Thr Tyr Glu Arg Glu Met Ser Lys Gly
            500                 505                 510         
Glu Val Val Asn Gly Val Asn Ser Tyr Met Asn Gln His Gly Val Thr
        515                 520                 525             
Lys Glu Glu Ala Val Glu Glu Leu Arg Lys Met Ala Arg Asp Asn Tyr
    530                 535                 540                 
Lys Ile Val Met Glu Glu Leu Leu Thr Ile Thr Asp Val Pro Arg Pro
545                 550                 555                 560 
Val Leu Val Arg Cys Leu Asn Leu Ala Arg Leu Phe Asp Val Phe Cys
                565                 570                 575     
Lys His Gly Asn Asp Glu Phe Thr Tyr Pro His Gly Asn Leu Lys Asp
            580                 585                 590         
Leu Ile Thr Ser Ile Phe Ile His Pro Ile Pro Val
        595                 600                 


<210> 368
<211> 600
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein Acc. No.
      NP_193754

<400> 368
Met Glu Ala Ile Lys Thr Phe Ser Pro Lys Phe Gly Phe Gln Ile Ser
 1               5                  10                  15      
Leu Ser Pro Arg Thr His Leu Thr Pro Val Arg Phe Pro Pro Thr Ala
            20                  25                  30          
Cys Pro Val Lys Pro Ala Asn Leu Val Arg Leu Lys Ala Thr Arg Ala
        35                  40                  45              
Leu Ile Arg Asp Pro Gln Glu Ser Asn Arg Lys Phe Gln Lys Phe Pro
    50                  55                  60                  
Pro Ser Glu Trp Thr Asn Arg Phe Asp Ser Val Ser Val Asp Ala Ser
65                  70                  75                  80  
Glu Met Asp Ala Leu Arg Lys Glu Ile Asp Lys Ile Ile Pro Asn Val
                85                  90                  95      
Lys Lys Glu Leu Met Ser Ser Gln Gly Ile Glu Ser Thr Lys Lys Lys
            100                 105                 110         
Ile Leu Met Val Tyr Leu Leu Val Ser Leu Gly Leu Ala Tyr His Phe
        115                 120                 125             
Glu Asp Glu Ile Glu Glu Cys Leu Lys Glu Gly Phe Glu Thr Ile Glu
    130                 135                 140                 
Glu Met Met Ala Gly Glu Asp Asn Leu Tyr Thr Ile Ser Ile Ile Phe
145                 150                 155                 160 
Leu Val Leu Arg Thr Tyr Gly His His Met Ser Ser Asp Ile Phe Gln
                165                 170                 175     
Lys Phe Lys Gly Asn Asp Gly Asn Phe Lys Gly Cys Ile Ser Gly Asp
            180                 185                 190         
Ala Lys Gly Leu Leu Ala Leu Tyr Glu Ala Ala Gln Leu Arg Thr Thr
        195                 200                 205             
Thr Glu Tyr Ile Met Glu Glu Ala Leu Ser Phe Thr Ser Ser Asn Leu
    210                 215                 220                 
Glu Leu Leu Ala Ala Asp Gly Arg Cys Pro Pro His Leu Ser Lys His
225                 230                 235                 240 
Ile Arg Asn Ala Leu Gly Leu Ser Gln His Lys Gln Met Glu Val Leu
                245                 250                 255     
Val Ala Val Glu Tyr Ile Ser Phe Tyr Glu Gln Glu Lys Asp His Asp
            260                 265                 270         
Lys Ile Leu Leu Lys Phe Ala Lys Leu Asn Phe Lys Leu Met Gln Leu
        275                 280                 285             
His Tyr Leu Glu Glu Leu Lys Val Val Thr Lys Trp Tyr Lys Glu His
    290                 295                 300                 
Asp Phe Ala Ser Asn Leu Pro Pro Tyr Phe Lys Tyr Val Ile Val Glu
305                 310                 315                 320 
Asn His Phe Phe Ala Ile Thr Met Tyr Phe Glu Pro Lys Phe Ser Gln
                325                 330                 335     
Lys Arg Ile Met Leu Ala Lys Tyr Phe Thr Val Leu Val Leu Leu Asp
            340                 345                 350         
Asp Thr Cys Asp Arg Tyr Ala Ser Leu Ser Glu Ala Glu Ser Leu Thr
        355                 360                 365             
Asn Ser Leu Glu Arg Trp Ala Pro Asp Asp Ala Met Asp Lys Gln Pro
    370                 375                 380                 
His Tyr Leu Lys Phe Val Phe Lys Phe Ile Met Gly Cys Phe Glu Glu
385                 390                 395                 400 
Phe Glu Arg Glu Leu Ala Ser Glu Gly Arg Ser Tyr Ser Val Lys Ala
                405                 410                 415     
Thr Leu Glu Glu Phe Lys Thr Ile Val Lys Ala Asn Phe Asp Phe Ala
            420                 425                 430         
Lys Leu Ala His Thr Gly His Val Pro Ser Phe Lys Glu Tyr Met Glu
        435                 440                 445             
Val Gly Glu Val Glu Val Gly Val Cys Ala Thr Leu Ala Gly Asn Leu
    450                 455                 460                 
Met Cys Ile Gly His Ile Gly Asp Glu Gly Val Tyr Glu Trp Leu Lys
465                 470                 475                 480 
Ser Arg Pro Lys Phe Leu Lys Ala Ala Ser Thr Tyr Gly Arg Leu Met
                485                 490                 495     
Asn Asp Ile Ala Gly Phe Glu Asp Asp Met Lys Arg Glu Tyr Val Ile
            500                 505                 510         
Thr Gly Val Asn Thr Tyr Met Lys Gln Tyr Gly Leu Thr Lys Met Glu
        515                 520                 525             
Ala Ile Arg Glu Leu Gln Asn Leu Val Glu Tyr Asn His Thr Ile Met
    530                 535                 540                 
Asn Glu Glu Phe Leu Lys Thr Thr Asp Leu Pro Arg Gln Ile Arg Lys
545                 550                 555                 560 
Gln Val Ile Asn Val Ala Arg Ser Leu Asn Val Ser Tyr Thr Glu Gly
                565                 570                 575     
Glu Gly Phe Thr His Thr Lys Gly Lys Val Asp Glu Tyr Ile Thr Ser
            580                 585                 590         
Leu Phe Ile Thr Pro Ile Arg Ile
        595                 600 


<210> 369
<211> 802
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> GA1 ent-copalyl diphospahte synthase Acc. No.
      NP_192187

<400> 369
Met Ser Leu Gln Tyr His Val Leu Asn Ser Ile Pro Ser Thr Thr Phe
 1               5                  10                  15      
Leu Ser Ser Thr Lys Thr Thr Ile Ser Ser Ser Phe Leu Thr Ile Ser
            20                  25                  30          
Gly Ser Pro Leu Asn Val Ala Arg Asp Lys Ser Arg Ser Gly Ser Ile
        35                  40                  45              
His Cys Ser Lys Leu Arg Thr Gln Glu Tyr Ile Asn Ser Gln Glu Val
    50                  55                  60                  
Gln His Asp Leu Pro Leu Ile His Glu Trp Gln Gln Leu Gln Gly Glu
65                  70                  75                  80  
Asp Ala Pro Gln Ile Ser Val Gly Ser Asn Ser Asn Ala Phe Lys Glu
                85                  90                  95      
Ala Val Lys Ser Val Lys Thr Ile Leu Arg Asn Leu Thr Asp Gly Glu
            100                 105                 110         
Ile Thr Ile Ser Ala Tyr Asp Thr Ala Trp Val Ala Leu Ile Asp Ala
        115                 120                 125             
Gly Asp Lys Thr Pro Ala Phe Pro Ser Ala Val Lys Trp Ile Ala Glu
    130                 135                 140                 
Asn Gln Leu Ser Asp Gly Ser Trp Gly Asp Ala Tyr Leu Phe Ser Tyr
145                 150                 155                 160 
His Asp Arg Leu Ile Asn Thr Leu Ala Cys Val Val Ala Leu Arg Ser
                165                 170                 175     
Trp Asn Leu Phe Pro His Gln Cys Asn Lys Gly Ile Thr Phe Phe Arg
            180                 185                 190         
Glu Asn Ile Gly Lys Leu Glu Asp Glu Asn Asp Glu His Met Pro Ile
        195                 200                 205             
Gly Phe Glu Val Ala Phe Pro Ser Leu Leu Glu Ile Ala Arg Gly Ile
    210                 215                 220                 
Asn Ile Asp Val Pro Tyr Asp Ser Pro Val Leu Lys Asp Ile Tyr Ala
225                 230                 235                 240 
Lys Lys Glu Leu Lys Leu Thr Arg Ile Pro Lys Glu Ile Met His Lys
                245                 250                 255     
Ile Pro Thr Thr Leu Leu His Ser Leu Glu Gly Met Arg Asp Leu Asp
            260                 265                 270         
Trp Glu Lys Leu Leu Lys Leu Gln Ser Gln Asp Gly Ser Phe Leu Phe
        275                 280                 285             
Ser Pro Ser Ser Thr Ala Phe Ala Phe Met Gln Thr Arg Asp Ser Asn
    290                 295                 300                 
Cys Leu Glu Tyr Leu Arg Asn Ala Val Lys Arg Phe Asn Gly Gly Val
305                 310                 315                 320 
Pro Asn Val Phe Pro Val Asp Leu Phe Glu His Ile Trp Ile Val Asp
                325                 330                 335     
Arg Leu Gln Arg Leu Gly Ile Ser Arg Tyr Phe Glu Glu Glu Ile Lys
            340                 345                 350         
Glu Cys Leu Asp Tyr Val His Arg Tyr Trp Thr Asp Asn Gly Ile Cys
        355                 360                 365             
Trp Ala Arg Cys Ser His Val Gln Asp Ile Asp Asp Thr Ala Met Ala
    370                 375                 380                 
Phe Arg Leu Leu Arg Gln His Gly Tyr Gln Val Ser Ala Asp Val Phe
385                 390                 395                 400 
Lys Asn Phe Glu Lys Glu Gly Glu Phe Phe Cys Phe Val Gly Gln Ser
                405                 410                 415     
Asn Gln Ala Val Thr Gly Met Phe Asn Leu Tyr Arg Ala Ser Gln Leu
            420                 425                 430         
Ala Phe Pro Arg Glu Glu Ile Leu Lys Asn Ala Lys Glu Phe Ser Tyr
        435                 440                 445             
Asn Tyr Leu Leu Glu Lys Arg Glu Arg Glu Glu Leu Ile Asp Lys Trp
    450                 455                 460                 
Ile Ile Met Lys Asp Leu Pro Gly Glu Ile Gly Phe Ala Leu Glu Ile
465                 470                 475                 480 
Pro Trp Tyr Ala Ser Leu Pro Arg Val Glu Thr Arg Phe Tyr Ile Asp
                485                 490                 495     
Gln Tyr Gly Gly Glu Asn Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg
            500                 505                 510         
Met Pro Tyr Val Asn Asn Asn Gly Tyr Leu Glu Leu Ala Lys Gln Asp
        515                 520                 525             
Tyr Asn Asn Cys Gln Ala Gln His Gln Leu Glu Trp Asp Ile Phe Gln
    530                 535                 540                 
Lys Trp Tyr Glu Glu Asn Arg Leu Ser Glu Trp Gly Val Arg Arg Ser
545                 550                 555                 560 
Glu Leu Leu Glu Cys Tyr Tyr Leu Ala Ala Ala Thr Ile Phe Glu Ser
                565                 570                 575     
Glu Arg Ser His Glu Arg Met Val Trp Ala Lys Ser Ser Val Leu Val
            580                 585                 590         
Lys Ala Ile Ser Ser Ser Phe Gly Glu Ser Ser Asp Ser Arg Arg Ser
        595                 600                 605             
Phe Ser Asp Gln Phe His Glu Tyr Ile Ala Asn Ala Arg Arg Ser Asp
    610                 615                 620                 
His His Phe Asn Asp Arg Asn Met Arg Leu Asp Arg Pro Gly Ser Val
625                 630                 635                 640 
Gln Ala Ser Arg Leu Ala Gly Val Leu Ile Gly Thr Leu Asn Gln Met
                645                 650                 655     
Ser Phe Asp Leu Phe Met Ser His Gly Arg Asp Val Asn Asn Leu Leu
            660                 665                 670         
Tyr Leu Ser Trp Gly Asp Trp Met Glu Lys Trp Lys Leu Tyr Gly Asp
        675                 680                 685             
Glu Gly Glu Gly Glu Leu Met Val Lys Met Ile Ile Leu Met Lys Asn
    690                 695                 700                 
Asn Asp Leu Thr Asn Phe Phe Thr His Thr His Phe Val Arg Leu Ala
705                 710                 715                 720 
Glu Ile Ile Asn Arg Ile Cys Leu Pro Arg Gln Tyr Leu Lys Ala Arg
                725                 730                 735     
Arg Asn Asp Glu Lys Glu Lys Thr Ile Lys Ser Met Glu Lys Glu Met
            740                 745                 750         
Gly Lys Met Val Glu Leu Ala Leu Ser Glu Ser Asp Thr Phe Arg Asp
        755                 760                 765             
Val Ser Ile Thr Phe Leu Asp Val Ala Lys Ala Phe Tyr Tyr Phe Ala
    770                 775                 780                 
Leu Cys Gly Asp His Leu Gln Thr His Ile Ser Lys Val Leu Phe Gln
785                 790                 795                 800 
Lys Val
        


<210> 370
<211> 557
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein Acc. No.
      NP_199276

<400> 370
Met Glu Ala Leu Gly Asn Phe Asp Tyr Glu Ser Tyr Thr Asn Phe Thr
 1               5                  10                  15      
Lys Leu Pro Ser Ser Gln Trp Gly Asp Gln Phe Leu Lys Phe Ser Ile
            20                  25                  30          
Ala Asp Ser Asp Phe Asp Val Leu Glu Arg Glu Ile Glu Val Leu Lys
        35                  40                  45              
Pro Lys Val Arg Glu Asn Ile Phe Val Ser Ser Ser Thr Asp Lys Asp
    50                  55                  60                  
Ala Met Lys Lys Thr Ile Leu Ser Ile His Phe Leu Asp Ser Leu Gly
65                  70                  75                  80  
Leu Ser Tyr His Phe Glu Lys Glu Ile Glu Glu Ser Leu Lys His Ala
                85                  90                  95      
Phe Glu Lys Ile Glu Asp Leu Ile Ala Asp Glu Asn Lys Leu His Thr
            100                 105                 110         
Ile Ser Thr Ile Phe Arg Val Phe Arg Thr Tyr Gly Tyr Tyr Met Ser
        115                 120                 125             
Ser Asp Val Phe Lys Ile Phe Lys Gly Asp Asp Gly Lys Phe Lys Glu
    130                 135                 140                 
Ser Leu Ile Glu Asp Val Lys Gly Met Leu Ser Phe Tyr Glu Ala Val
145                 150                 155                 160 
His Phe Gly Thr Thr Thr Asp His Ile Leu Asp Glu Ala Leu Ser Phe
                165                 170                 175     
Thr Leu Asn His Leu Glu Ser Leu Ala Thr Gly Arg Arg Ala Ser Pro
            180                 185                 190         
Pro His Ile Ser Lys Leu Ile Gln Asn Ala Leu His Ile Pro Gln His
        195                 200                 205             
Arg Asn Ile Gln Ala Leu Val Ala Arg Glu Tyr Ile Ser Phe Tyr Glu
    210                 215                 220                 
His Glu Glu Asp His Asp Glu Thr Leu Leu Lys Leu Ala Lys Leu Asn
225                 230                 235                 240 
Phe Lys Phe Leu Gln Leu His Tyr Phe Gln Glu Leu Lys Thr Ile Thr
                245                 250                 255     
Met Trp Trp Thr Lys Leu Asp His Thr Ser Asn Leu Pro Pro Asn Phe
            260                 265                 270         
Arg Glu Arg Thr Val Glu Thr Trp Phe Ala Ala Leu Met Met Tyr Phe
        275                 280                 285             
Glu Pro Gln Phe Ser Leu Gly Arg Ile Met Ser Ala Lys Leu Tyr Leu
    290                 295                 300                 
Val Ile Thr Phe Leu Asp Asp Ala Cys Asp Thr Tyr Gly Ser Ile Ser
305                 310                 315                 320 
Glu Val Glu Ser Leu Ala Asp Cys Leu Glu Arg Trp Asp Pro Asp Tyr
                325                 330                 335     
Met Glu Asn Leu Gln Gly His Met Lys Thr Ala Phe Lys Phe Val Met
            340                 345                 350         
Tyr Leu Phe Lys Glu Tyr Glu Glu Ile Leu Arg Ser Gln Gly Arg Ser
        355                 360                 365             
Phe Val Leu Glu Lys Met Ile Glu Glu Phe Lys Ile Ile Ala Arg Lys
    370                 375                 380                 
Asn Leu Glu Leu Val Lys Trp Ala Arg Gly Gly His Val Pro Ser Phe
385                 390                 395                 400 
Asp Glu Tyr Ile Glu Ser Gly Gly Ala Glu Ile Gly Thr Tyr Ala Thr
                405                 410                 415     
Ile Ala Cys Ser Ile Met Gly Leu Gly Glu Ile Gly Lys Lys Glu Ala
            420                 425                 430         
Phe Glu Trp Leu Ile Ser Arg Pro Lys Leu Val Arg Ile Leu Gly Ala
        435                 440                 445             
Lys Thr Arg Leu Met Asp Asp Ile Ala Asp Phe Glu Glu Asp Met Glu
    450                 455                 460                 
Lys Gly Tyr Thr Ala Asn Ala Leu Asn Tyr Tyr Met Asn Glu His Gly
465                 470                 475                 480 
Val Thr Lys Glu Glu Ala Ser Arg Glu Leu Glu Lys Met Asn Gly Asp
                485                 490                 495     
Met Asn Lys Ile Val Asn Glu Glu Cys Leu Lys Ile Thr Thr Met Pro
            500                 505                 510         
Arg Arg Ile Leu Met Gln Ser Val Asn Tyr Ala Arg Ser Leu Asp Val
        515                 520                 525             
Leu Tyr Thr Ala Asp Asp Val Tyr Asn His Arg Glu Gly Lys Leu Lys
    530                 535                 540                 
Glu Tyr Met Arg Leu Leu Leu Val Asp Pro Ile Leu Leu
545                 550                 555         


<210> 371
<211> 605
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase Acc. No. AAO85535

<400> 371
Met Glu Ala Thr Ser Val Phe Arg Pro Lys Leu Gly Ser Gln Phe Ser
 1               5                  10                  15      
Leu Pro Ser Thr Thr Asn Leu Phe Pro Leu Arg Lys Leu Tyr Gly Phe
            20                  25                  30          
Pro Leu Thr Ser Phe Pro Gly Lys Pro Ile Lys Arg Ile Arg Leu Lys
        35                  40                  45              
Ala Ser Asn Thr Leu Thr Phe Asp Asp Lys Glu Arg Thr Arg Lys Phe
    50                  55                  60                  
Lys Lys Leu Pro Leu Ser Glu Trp Thr His Tyr Phe His Ser Ile Pro
65                  70                  75                  80  
Leu Asp Ile Ser Glu Met Asp Ala Leu Lys Glu Glu Ile Asp Glu Leu
                85                  90                  95      
Lys Pro Lys Val Lys Asn Thr Phe Met Ser Ser Gln Gly Ser Asp Ser
            100                 105                 110         
Thr Lys Thr Lys Ile Leu Met Ile Tyr Leu Phe Val Ser Leu Gly Leu
        115                 120                 125             
Ala Tyr His Phe Glu Glu Glu Ile Tyr Glu Thr Leu Lys Glu Gly Phe
    130                 135                 140                 
Glu Asn Ile Glu Lys Ile Met Ala Gly Glu Glu Asp Leu Tyr Thr Val
145                 150                 155                 160 
Ser Ile Ile Phe Trp Val Phe Arg Arg Tyr Gly His Tyr Ile Ser Ser
                165                 170                 175     
Asp Val Phe Gln Arg Phe Lys Gly Ser Asn Gly Ser Phe Lys Glu Ser
            180                 185                 190         
Leu Ile Gly Asp Ala Lys Gly Met Leu Ser Leu Tyr Glu Ala Ala His
        195                 200                 205             
Leu Ala Thr Thr Lys Asp Tyr Ile Leu Asp Glu Ala Leu Ile Phe Thr
    210                 215                 220                 
Ser Ser His Leu Glu Thr Leu Val Ala Thr Gly Thr Cys Pro Pro His
225                 230                 235                 240 
Leu Leu Ala Arg Ile Arg Asn Ala Leu Ser Ile Cys Gln His Trp Asn
                245                 250                 255     
Phe Glu Val Leu Val Pro Leu Asp Phe Ile Pro Phe Tyr Glu Gln Glu
            260                 265                 270         
Lys Asp His Asp Glu Met Leu Leu Lys Phe Ala Lys Leu Ser Phe Lys
        275                 280                 285             
Tyr Leu Lys Leu Ile Tyr Leu Gln Asp Leu Lys Ile Leu Thr Lys Trp
    290                 295                 300                 
Tyr Lys Lys Leu Asp Phe Pro Ser Lys Phe Pro Pro Tyr Phe Lys Asp
305                 310                 315                 320 
Arg Cys Val Glu Asn Tyr Phe Phe Val Leu Pro Val Phe Phe Glu Pro
                325                 330                 335     
Gln Leu Ser Ser Ala Arg Met Leu Leu Thr Lys Gly Phe Ile Leu Leu
            340                 345                 350         
Gly Ile Gln Asp Asp Thr Phe Asp Arg Tyr Ala Ser Ile Ser Glu Ala
        355                 360                 365             
Glu Ser Leu Gly Asn Ser Leu Lys Arg Trp Ala Pro Asp His Ser Met
    370                 375                 380                 
Asp Lys Gln Pro Glu Tyr Leu Lys Ser Val Leu Lys Val Ile Leu Asp
385                 390                 395                 400 
Thr Phe Gln Glu Phe Glu Lys Glu Leu Ser Pro Glu Gly Arg Ser Tyr
                405                 410                 415     
Ser Val Lys Tyr Thr Ile Glu Glu Phe Gln Ala Ser Ser Lys Ala Asn
            420                 425                 430         
Val Glu Leu Ala Lys Trp Ala Gln Val Ser His Val Pro Ser Phe Glu
        435                 440                 445             
Lys Tyr Met Glu Val Gly Gln Met Glu Ile Thr Ala Cys Val Thr Val
    450                 455                 460                 
Ala Tyr Ile Leu Met Ser Met Gly Lys Thr Asp Ser Lys Glu Ala Phe
465                 470                 475                 480 
Glu Trp Leu Lys Ser Arg Pro Lys Leu Val Gln Ser Leu Cys Thr Lys
                485                 490                 495     
Gly Arg Leu Met Asn Asp Ile Ala Gly Phe Glu Asp Asp Met Ser Arg
            500                 505                 510         
Gly Tyr Val Val Asn Ala Val Asn Cys Tyr Met Lys Gln Tyr Gly Val
        515                 520                 525             
Thr Glu Lys Glu Ala Phe Lys Glu Ile Arg Lys Met Val Val Asn Thr
    530                 535                 540                 
His Lys Thr Leu Asn Glu Glu Phe Leu Thr Thr Thr Cys Val Pro His
545                 550                 555                 560 
Tyr Val Leu Arg Glu Thr Met Asp Phe Ala Arg Met Ile Ile Val Thr
                565                 570                 575     
Tyr Asn Gly Tyr Glu Gly Phe Thr Arg Pro Asp Glu Gly Ile Ile Lys
            580                 585                 590         
Glu Tyr Met Thr Ser Leu Phe Val Asp Gln Ile Asp Leu
        595                 600                 605 


<210> 372
<211> 603
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase Acc. No. AAO85536

<400> 372
Met Glu Ala Ser Lys Cys Phe Gly Pro Arg Thr Leu Pro Ile Ile His
 1               5                  10                  15      
Asn Val Pro Leu Cys Leu Lys Thr Asn Phe Ser Leu Phe Pro Arg Cys
            20                  25                  30          
Leu Leu Gln Ser Gln Ser Leu Ser Ser Lys Lys Ser Thr Lys His Asp
        35                  40                  45              
Leu Phe Arg Val Lys Ala Glu Thr Ser Gly Asp Leu Glu Asn Thr Arg
    50                  55                  60                  
Pro Leu Thr Tyr Tyr Ser Pro Ser Leu Trp Gly Asp His Phe Leu Ser
65                  70                  75                  80  
Val Pro Ile Asp Glu Ser Lys Phe Glu Ala Leu Glu Lys Glu Ile Glu
                85                  90                  95      
Ser Val Phe Lys Pro Lys Val Arg Asp Met Leu Met Ser Pro His Ser
            100                 105                 110         
Ser Asp Lys Glu Arg Ile Arg Leu Ile His Leu Leu Ile Ser Leu Gly
        115                 120                 125             
Ile Ala Tyr Tyr Tyr Glu Asn Glu Ile Glu Glu Ile Leu His Lys Ala
    130                 135                 140                 
Tyr Gly Lys Leu Ala Cys Leu Ile Ser Asp Glu Asp Asp Leu Glu Thr
145                 150                 155                 160 
Ile Ala Ile Met Phe Glu Val Phe Arg Leu Tyr Gly His Lys Met Pro
                165                 170                 175     
Cys Asp Val Phe Glu Arg Phe Lys Ser Glu Asp Gly Lys Phe Lys Glu
            180                 185                 190         
Ser Leu Val Gly Asp Val Arg Gly Leu Leu Gln Met Tyr Glu Ala Ala
        195                 200                 205             
His Leu Gly Ala Pro Ser Glu Asp Ile Met Asp Glu Ala Leu Ser Phe
    210                 215                 220                 
Ala Arg Tyr His Leu Glu Ser Leu Val Ser His Glu Thr Ser Ser Asn
225                 230                 235                 240 
Leu Phe Asn His Val Gln Asn Glu Leu Tyr Arg Ala Arg Tyr His Ser
                245                 250                 255     
Ile Glu Ile Leu Val Ala Arg Gln Tyr Ile Ser Phe Tyr Glu Gln Glu
            260                 265                 270         
Glu Asp His Asp Glu Thr Leu Leu Arg Phe Ser Lys Leu Asn Phe Asn
        275                 280                 285             
Phe Cys Gln Met His Tyr Val Lys Asp Leu Lys Ile Val Thr Arg Trp
    290                 295                 300                 
Trp Lys Glu Leu Gly Ile Ala Ser Lys Leu Pro Tyr Ser Ile Arg Glu
305                 310                 315                 320 
Arg Asn Val Glu Val Tyr Leu Gly Ser Leu Gly Met Phe Phe Glu Pro
                325                 330                 335     
Arg Tyr Ser Leu Ala Arg Ile Phe Ser Ala Lys Leu Thr Met Ile Leu
            340                 345                 350         
Thr Val Val Asp Asp Thr Cys Asp Ser Tyr Ala Thr Leu Pro Glu Val
        355                 360                 365             
Lys Ser Leu His Asp Ala Phe His Arg Trp Asp Leu Arg Ala Met Glu
    370                 375                 380                 
Glu Leu Pro Arg Tyr Met Arg Ile Ile Tyr Gln Ser Val Phe Glu Thr
385                 390                 395                 400 
Val Glu Asp Ile Asp Arg Glu Met Ile Ala Arg Gly Lys His Gly Arg
                405                 410                 415     
Leu Gln Leu Thr Ile Asp Glu Ile Lys Ser Leu Met Ile Trp Tyr Leu
            420                 425                 430         
Gly Ile Ala Lys Trp Ala Arg Ser Asp Gln Val Pro Ser Phe Glu Asp
        435                 440                 445             
Tyr Met Glu Ile Gly Thr Pro Ser Ser Ala Leu Asp Asp Leu Ala Ser
    450                 455                 460                 
Tyr Gly Phe Ile Ala Met Asp Asp Cys Asp Gln Lys Lys Leu Lys Glu
465                 470                 475                 480 
Trp Phe Tyr Ser Lys Pro Lys Ile Phe His Ala Leu Asn Ala Leu Phe
                485                 490                 495     
Arg Ile Arg Asn Asp Ile Val Thr Phe Glu Gln Glu Met Ser Arg Gly
            500                 505                 510         
Glu Val Ala Asn Gly Val Asn Cys Tyr Met Lys Gln His Gly Val Thr
        515                 520                 525             
Lys Glu Ala Ala Val Glu Glu Leu Arg Lys Met Glu Arg Glu Asn Tyr
    530                 535                 540                 
Lys Ile Met Ile Glu Glu Phe Met Thr Ser Lys Ala Met Pro Arg Gln
545                 550                 555                 560 
Ile Leu Val Arg Pro Val Asn Ile Ala Arg Val Met Asp Leu Tyr Tyr
                565                 570                 575     
Lys Glu Ala Asp Gly Phe Gly His Pro Asp Gln Lys Leu Leu Gln Leu
            580                 585                 590         
Ile Ala Ser Leu Phe Leu His Pro Ile Pro Leu
        595                 600             


<210> 373
<211> 605
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase Acc. No. AAO85537

<400> 373
Met Asp Ala Thr Arg Thr Phe Phe Gly Leu Pro Asn Val His Asn Val
 1               5                  10                  15      
Pro Leu Cys Leu Thr Ser Asn Leu Ser Leu Phe Pro Gln Arg Leu Leu
            20                  25                  30          
Gln Lys His Thr Leu Pro Leu Lys Pro Val Lys Arg His His Leu Val
        35                  40                  45              
Cys Val Arg Ser Thr Lys Ser Ser Asp Asp Leu Glu Gly Ser Arg Pro
    50                  55                  60                  
Ser Thr Tyr Phe Ser Pro Ser Leu Trp Gly Asp His Phe Leu Ser Val
65                  70                  75                  80  
Ser Leu Asp Arg Gly Glu Phe Asp Glu Leu Glu Arg Glu Ile Glu Thr
                85                  90                  95      
Met Lys Pro Leu Val Lys Asp Met Leu Met Ser Ser Gln Ser Ser Asp
            100                 105                 110         
Lys Glu Lys Ile Arg Leu Ile His Leu Leu Val Ser Leu Gly Ser Ser
        115                 120                 125             
Tyr His Phe Asp Lys Glu Ile Gln Asp Ile Leu Lys His Ser Phe Thr
    130                 135                 140                 
Lys Leu Asp Asp Ile Ile Val Gly Glu Asp Asp Leu Glu Thr Ile Ser
145                 150                 155                 160 
Ile Met Phe Glu Val Phe Arg Leu Tyr Gly His Lys Met Ser Cys Asp
                165                 170                 175     
Ala Phe Asp Arg Phe Arg Gly Glu Asp Gly Arg Phe Lys Glu Ser Leu
            180                 185                 190         
Ala Lys Asp Val Arg Gly Met Leu Gln Leu Phe Glu Val Ala His Leu
        195                 200                 205             
Gly Thr Pro Ser Glu Asp Ile Met Asp Glu Ala Ser Ser Phe Ala Gln
    210                 215                 220                 
Asn His Leu Glu Ser Trp Ile Ala Gly Asn Val Ser Gly Ala Thr Pro
225                 230                 235                 240 
His Leu Leu Lys His Ile Gln Asn Ser Leu Tyr Ile Pro Arg Tyr Cys
                245                 250                 255     
Asn Ile Glu Val Leu Val Ala Arg Glu Tyr Ile Ser Tyr Tyr Glu Gln
            260                 265                 270         
Glu Glu Gly Tyr Asp Glu Ile Leu Leu Lys Phe Ala Lys Leu Asn Phe
        275                 280                 285             
Asn Leu Cys Gln Phe Arg Tyr Ile Gln Glu Leu Lys Thr Leu Thr Lys
    290                 295                 300                 
Trp Trp Lys Asp Leu Asp Leu Ala Ser Lys Leu Pro Tyr Ile Arg Asp
305                 310                 315                 320 
Arg Leu Val Glu Ser His Leu Gly Gly Leu Gly Pro Tyr Phe Glu Pro
                325                 330                 335     
His Tyr Ser Leu Gly Arg Ile Ile Val Ala Lys Ile Ile Met Thr Met
            340                 345                 350         
Val Val Val Asp Asp Thr Tyr Asp Ala His Ala Thr Val Pro Glu Val
        355                 360                 365             
Ala Val Leu Thr Glu Cys Leu Gln Arg Leu Asn Ile Gly Ala Asp Asp
    370                 375                 380                 
Lys Leu Pro Asp Tyr Leu Arg Ile Val Leu Glu Ser Val Phe Glu Val
385                 390                 395                 400 
Met Gly Glu Ile Glu Gln Glu Met Arg Pro Lys Gly Arg Ser Tyr Gly
                405                 410                 415     
Val Lys Gln Val Leu Glu Arg Phe Lys Asn Val Ala Lys Ala Asp Lys
            420                 425                 430         
Gln Leu Thr Glu Trp Ala Arg Thr Gly His Val Pro Ser Phe Asp Glu
        435                 440                 445             
Tyr Met Lys Val Gly Leu Val Thr Ala Gly Met Asp Gly Tyr Ala Gly
    450                 455                 460                 
Tyr Cys Phe Ile Gly Met Glu Asp Ile Ser Glu Lys Glu Ala Phe Glu
465                 470                 475                 480 
Trp Leu Ser Ser Asn Pro Leu Ile Ile Gln Ala Leu Asn Val Met Phe
                485                 490                 495     
Arg Leu Ala Asn Asp Val Gly Thr Tyr Glu Thr Glu Ile Asn Arg Gly
            500                 505                 510         
Glu Val Ala Asn Gly Leu Asn Cys Tyr Met Lys Gln Tyr Gly Val Thr
        515                 520                 525             
Lys Glu Glu Ala Ser Gln Glu Leu Arg Lys Ile Tyr Ser Asn Asn Lys
    530                 535                 540                 
Lys Val Val Met Glu Glu Phe Met Asn Ser His Asp His Val Pro Arg
545                 550                 555                 560 
Gln Val Leu Leu Arg Cys Leu Asn Phe Ala Arg Leu Phe Asp Val Met
                565                 570                 575     
Tyr Thr Glu Gly Asp Gly Tyr Ser Glu Pro Lys Gly Lys Ile Glu His
            580                 585                 590         
Phe Met Thr Ser Leu Tyr Val His Pro Ile Pro Leu Ser
        595                 600                 605 


<210> 374
<211> 547
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> beta-caryophyllene/alpha-humulene synthase  Acc.
      No. AAO85539

<400> 374
Met Gly Ser Glu Val Asn Arg Pro Leu Ala Asp Phe Pro Ala Asn Ile
 1               5                  10                  15      
Trp Glu Asp Pro Leu Thr Ser Phe Ser Lys Ser Asp Leu Gly Thr Glu
            20                  25                  30          
Thr Phe Lys Glu Lys His Ser Thr Leu Lys Glu Ala Val Lys Glu Ala
        35                  40                  45              
Phe Met Ser Ser Lys Ala Asn Pro Ile Glu Asn Ile Lys Phe Ile Asp
    50                  55                  60                  
Ala Leu Cys Arg Leu Gly Val Ser Cys His Phe Glu Lys Asp Ile Val
65                  70                  75                  80  
Glu Gln Leu Asp Lys Ser Phe Asp Cys Leu Asp Phe Pro Gln Met Val
                85                  90                  95      
Arg Gln Glu Gly Cys Asp Leu Tyr Thr Val Gly Ile Ile Phe Gln Val
            100                 105                 110         
Phe Arg Gln Phe Gly Phe Lys Leu Ser Ala Asp Val Phe Glu Lys Phe
        115                 120                 125             
Lys Asp Glu Asn Gly Lys Phe Lys Gly His Leu Val Thr Asp Ala Tyr
    130                 135                 140                 
Gly Met Leu Ser Leu Tyr Glu Ala Ala Gln Trp Gly Thr His Gly Glu
145                 150                 155                 160 
Asp Ile Ile Asp Glu Ala Leu Ala Phe Ser Arg Ser His Leu Glu Glu
                165                 170                 175     
Ile Ser Ser Arg Ser Ser Pro His Leu Ala Ile Arg Ile Lys Asn Ala
            180                 185                 190         
Leu Lys His Pro Tyr His Lys Gly Ile Ser Arg Ile Glu Thr Arg Gln
        195                 200                 205             
Tyr Ile Ser Tyr Tyr Glu Glu Glu Glu Ser Cys Asp Pro Thr Leu Leu
    210                 215                 220                 
Glu Phe Ala Lys Ile Asp Phe Asn Leu Leu Gln Ile Leu His Arg Glu
225                 230                 235                 240 
Glu Leu Ala Cys Val Thr Arg Trp His His Glu Met Glu Phe Lys Ser
                245                 250                 255     
Lys Val Thr Tyr Thr Arg His Arg Ile Thr Glu Ala Tyr Leu Trp Ser
            260                 265                 270         
Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ser Gln Ala Arg Val Ile Thr
        275                 280                 285             
Thr Met Ala Leu Ile Leu Phe Thr Ala Leu Asp Asp Met Tyr Asp Ala
    290                 295                 300                 
Tyr Gly Thr Met Glu Glu Leu Glu Leu Phe Thr Asp Ala Met Asp Glu
305                 310                 315                 320 
Trp Leu Pro Val Val Pro Asp Glu Ile Pro Ile Pro Asp Ser Met Lys
                325                 330                 335     
Phe Ile Tyr Asn Val Thr Val Glu Phe Tyr Asp Lys Leu Asp Glu Glu
            340                 345                 350         
Leu Glu Lys Glu Gly Arg Ser Gly Cys Gly Phe His Leu Lys Lys Ser
        355                 360                 365             
Leu Gln Lys Thr Ala Asn Gly Tyr Met Gln Glu Ala Lys Trp Leu Lys
    370                 375                 380                 
Lys Asp Tyr Ile Ala Thr Phe Asp Glu Tyr Lys Glu Asn Ala Ile Leu
385                 390                 395                 400 
Ser Ser Gly Tyr Tyr Gly Leu Ile Ala Met Thr Phe Val Arg Met Thr
                405                 410                 415     
Asp Val Ala Lys Leu Asp Ala Phe Glu Trp Leu Asn Ser His Pro Lys
            420                 425                 430         
Ile Arg Val Ala Ser Glu Ile Ile Ser Arg Phe Thr Asp Asp Ile Ser
        435                 440                 445             
Ser Tyr Glu Phe Glu His Lys Arg Glu His Val Ala Thr Gly Ile Asp
    450                 455                 460                 
Cys Tyr Met Gln Gln Phe Gly Val Ser Lys Glu Arg Ala Val Glu Val
465                 470                 475                 480 
Met Gly Asn Ile Val Ser Asp Ala Trp Lys Asp Leu Asn Gln Glu Leu
                485                 490                 495     
Met Arg Pro His Val Phe Pro Phe Pro Leu Leu Met Arg Val Leu Asn
            500                 505                 510         
Leu Ser Arg Val Ile Asp Val Phe Tyr Arg Tyr Gln Asp Ala Tyr Thr
        515                 520                 525             
Asn Pro Lys Leu Leu Lys Glu His Ile Val Ser Leu Leu Ile Glu Thr
    530                 535                 540                 
Ile Pro Ile
545         


<210> 375
<211> 565
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> (E)-beta-ocimene synthase/ myrcene synthase  Acc.
      No. NP_567511

<400> 375
Met Pro Lys Arg Gln Ala Gln Arg Arg Phe Thr Arg Lys Thr Asp Ser
 1               5                  10                  15      
Lys Thr Pro Ser Gln Pro Leu Val Ser Arg Arg Ser Ala Asn Tyr Gln
            20                  25                  30          
Pro Ser Leu Trp Gln His Glu Tyr Leu Leu Ser Leu Gly Asn Thr Tyr
        35                  40                  45              
Val Lys Glu Asp Asn Val Glu Arg Val Thr Leu Leu Lys Gln Glu Val
    50                  55                  60                  
Ser Lys Met Leu Asn Glu Thr Glu Gly Leu Leu Glu Gln Leu Glu Leu
65                  70                  75                  80  
Ile Asp Thr Leu Gln Arg Leu Gly Val Ser Tyr His Phe Glu Gln Glu
                85                  90                  95      
Ile Lys Lys Thr Leu Thr Asn Val His Val Lys Asn Val Arg Ala His
            100                 105                 110         
Lys Asn Arg Ile Asp Arg Asn Arg Trp Gly Asp Leu Tyr Ala Thr Ala
        115                 120                 125             
Leu Glu Phe Arg Leu Leu Arg Gln His Gly Phe Ser Ile Ala Gln Asp
    130                 135                 140                 
Val Phe Asp Gly Asn Ile Gly Val Asp Leu Asp Asp Lys Asp Ile Lys
145                 150                 155                 160 
Gly Ile Leu Ser Leu Tyr Glu Ala Ser Tyr Leu Ser Thr Arg Ile Asp
                165                 170                 175     
Thr Lys Leu Lys Glu Ser Ile Tyr Tyr Thr Thr Lys Arg Leu Arg Lys
            180                 185                 190         
Phe Val Glu Val Asn Lys Asn Glu Thr Lys Ser Tyr Thr Leu Arg Arg
        195                 200                 205             
Met Val Ile His Ala Leu Glu Met Pro Tyr His Arg Arg Val Gly Arg
    210                 215                 220                 
Leu Glu Ala Arg Trp Tyr Ile Glu Val Tyr Gly Glu Arg His Asp Met
225                 230                 235                 240 
Asn Pro Ile Leu Leu Glu Leu Ala Lys Leu Asp Phe Asn Phe Val Gln
                245                 250                 255     
Ala Ile His Gln Asp Glu Leu Lys Ser Leu Ser Ser Trp Trp Ser Lys
            260                 265                 270         
Thr Gly Leu Thr Lys His Leu Asp Phe Val Arg Asp Arg Ile Thr Glu
        275                 280                 285             
Gly Tyr Phe Ser Ser Val Gly Val Met Tyr Glu Pro Glu Phe Ala Tyr
    290                 295                 300                 
His Arg Gln Met Leu Thr Lys Val Phe Met Leu Ile Thr Thr Ile Asp
305                 310                 315                 320 
Asp Ile Tyr Asp Ile Tyr Gly Thr Leu Glu Glu Leu Gln Leu Phe Thr
                325                 330                 335     
Thr Ile Val Glu Lys Trp Asp Val Asn Arg Leu Glu Glu Leu Pro Asn
            340                 345                 350         
Tyr Met Lys Leu Cys Phe Leu Cys Leu Val Asn Glu Ile Asn Gln Ile
        355                 360                 365             
Gly Tyr Phe Val Leu Arg Asp Lys Gly Phe Asn Val Ile Pro Tyr Leu
    370                 375                 380                 
Lys Glu Ser Trp Ala Asp Met Cys Thr Thr Phe Leu Lys Glu Ala Lys
385                 390                 395                 400 
Trp Tyr Lys Ser Gly Tyr Lys Pro Asn Phe Glu Glu Tyr Met Gln Asn
                405                 410                 415     
Gly Trp Ile Ser Ser Ser Val Pro Thr Ile Leu Leu His Leu Phe Cys
            420                 425                 430         
Leu Leu Ser Asp Gln Thr Leu Asp Ile Leu Gly Ser Tyr Asn His Ser
        435                 440                 445             
Val Val Arg Ser Ser Ala Thr Ile Leu Arg Leu Ala Asn Asp Leu Ala
    450                 455                 460                 
Thr Ser Ser Glu Glu Leu Ala Arg Gly Asp Thr Met Lys Ser Val Gln
465                 470                 475                 480 
Cys His Met His Glu Thr Gly Ala Ser Glu Ala Glu Ser Arg Ala Tyr
                485                 490                 495     
Ile Gln Gly Ile Ile Gly Val Ala Trp Asp Asp Leu Asn Met Glu Lys
            500                 505                 510         
Lys Ser Cys Arg Leu His Gln Gly Phe Leu Glu Ala Ala Ala Asn Leu
        515                 520                 525             
Gly Arg Val Ala Gln Cys Val Tyr Gln Tyr Gly Asp Gly His Gly Cys
    530                 535                 540                 
Pro Asp Lys Ala Lys Thr Val Asn His Val Arg Ser Leu Leu Val His
545                 550                 555                 560 
Pro Leu Pro Leu Asn
                565 


<210> 376
<211> 547
<212> PRT
<213> Artemisia annua

<220> 
<223> putative sesquiterpene cyclase Acc. No. CAB56499

<400> 376
Met Ser Leu Ile Val Glu Asp Val Ile Arg Pro Asn Ala Asn Phe Pro
 1               5                  10                  15      
Ser Glu Ile Trp Gly Asp Gln Phe Leu Ala Tyr Asp Gln Asp Glu Gln
            20                  25                  30          
Glu Gly Val Glu Gln Val Ile Lys Asp Leu Lys Glu Glu Val Lys Ser
        35                  40                  45              
Glu Leu Leu Thr Ala Leu Asn Ser Pro Thr Gln His Thr Glu Leu Leu
    50                  55                  60                  
Lys Phe Ile Asp Ala Ile Glu Arg Leu Gly Ile Ala Tyr Tyr Phe Glu
65                  70                  75                  80  
Glu Glu Ile Asn Gln Val Phe Gln His Met Tyr Thr Ala Tyr Gly Asp
                85                  90                  95      
Lys Trp Thr Gly Gly Asn Thr Ser Leu Trp Phe Arg Leu Met Arg Gln
            100                 105                 110         
His Gly Phe Phe Val Ser Ser Asp Ile Phe Ser Thr Tyr Lys Asp Lys
        115                 120                 125             
Glu Gly Arg Phe Lys Glu Ser Leu Glu Lys Asp Val His Gly Leu Leu
    130                 135                 140                 
Glu Leu Tyr Glu Ala Ala Tyr Met Phe Val Pro Gly Glu Gly Ile Leu
145                 150                 155                 160 
Asp Asp Ala Leu Val Phe Thr Arg Thr Cys Leu Asp Glu Ile Ala Lys
                165                 170                 175     
Asn Pro Ser Leu Ser Asn Ser Ala Ile Ser Ser Gln Ile Arg Glu Ala
            180                 185                 190         
Leu Thr Gln Pro Leu His Lys Arg Leu Pro Arg Leu Glu Ala Leu Arg
        195                 200                 205             
Tyr Ile Pro Phe Tyr Gln Gln Gln Ala Ser His Ser Glu Thr Leu Leu
    210                 215                 220                 
Lys Leu Ala Lys Leu Gly Phe Asn Gln Leu Gln Ser Leu His Lys Lys
225                 230                 235                 240 
Glu Leu Ser Ile Ile Ser Lys Trp Trp Lys Ser Phe Asp Val Ala Asn
                245                 250                 255     
Asn Leu Pro Tyr Ala Arg Asn Arg Pro Val Glu Cys Tyr Phe Trp Ala
            260                 265                 270         
Leu Ala Val Tyr Phe Glu Pro Gln Tyr Ser Glu Ser Arg Val Phe Leu
        275                 280                 285             
Ser Arg Phe Phe Ser Ile Gln Thr Phe Leu Asp Asp Thr Tyr Asp Ala
    290                 295                 300                 
Tyr Gly Thr Tyr Glu Glu Leu Glu Gln Phe Thr Glu Ala Ile Gln Arg
305                 310                 315                 320 
Trp Ser Ile Thr Cys Leu Asp Gly Leu Pro Glu Ser Met Lys Leu Ile
                325                 330                 335     
Phe Gln Met Leu Val Lys Ile Phe Glu Glu Ile Glu Glu Ile Leu Ser
            340                 345                 350         
Lys Asp Gly Lys Gln His His Val Asn Tyr Ile Lys Glu Thr Leu Lys
        355                 360                 365             
Glu Ala Val Gln Ser Tyr Met Thr Glu Ala Arg Trp Ala Lys Glu Glu
    370                 375                 380                 
Tyr Ile Pro Thr Ile Glu Glu His Thr Lys Val Ser Tyr Ile Ser Ile
385                 390                 395                 400 
Gly Tyr Lys Leu Ala Leu Val Ala Gly Phe Ala Cys Met Gly Asp Val
                405                 410                 415     
Ile Ala Asp Asp Ser Phe Glu Trp Val Phe Thr Asn Pro Pro Leu Val
            420                 425                 430         
Asn Ala Cys Cys Leu Leu Cys Arg Thr Met Asp Asp Leu Gly Ser His
        435                 440                 445             
Lys Gly Glu Gln Asp Arg Lys His Val Ala Ser Thr Ile Glu Cys Tyr
    450                 455                 460                 
Met Lys Gln Phe Asp Ala Ser Glu Gln Gln Ala Tyr Glu Ser Leu Asn
465                 470                 475                 480 
Lys Lys Val Glu Asp Ala Trp Lys Glu Ile Asn Arg Glu Phe Met Ile
                485                 490                 495     
Thr Cys Lys Asp Val Asn Ile His Val Ala Met Arg Val Leu Asn Phe
            500                 505                 510         
Ser Arg Ser Val Asp Val Leu Tyr Lys Asn Lys Asp His Phe Thr His
        515                 520                 525             
Val Gly Val Glu Val Ile Asn His Ile Lys Ser Leu Phe Val Asp Ala
    530                 535                 540                 
Ile Ile Thr
545         


<210> 377
<211> 577
<212> PRT
<213> Artemisia annua

<220> 
<223> putative sesquiterpene cyclase Acc. No. CAC12731

<400> 377
Met Ser Thr Leu Pro Ile Ser Ser Val Ser Phe Ser Ser Ser Thr Ser
 1               5                  10                  15      
Pro Leu Val Val Asp Asp Lys Val Ser Thr Lys Pro Asp Val Ile Arg
            20                  25                  30          
His Thr Met Asn Phe Asn Ala Ser Ile Trp Gly Asp Gln Phe Leu Thr
        35                  40                  45              
Tyr Asp Glu Pro Glu Asp Leu Val Met Lys Lys Gln Leu Val Glu Glu
    50                  55                  60                  
Leu Lys Glu Glu Val Lys Lys Glu Leu Ile Thr Ile Lys Gly Ser Asn
65                  70                  75                  80  
Glu Pro Met Gln His Val Lys Leu Ile Glu Leu Ile Asp Ala Val Gln
                85                  90                  95      
Arg Leu Gly Ile Ala Tyr His Phe Glu Glu Glu Ile Glu Glu Ala Leu
            100                 105                 110         
Gln His Ile His Val Thr Tyr Gly Glu Gln Trp Val Asp Lys Glu Asn
        115                 120                 125             
Leu Gln Ser Ile Ser Leu Trp Phe Arg Leu Leu Arg Gln Gln Gly Phe
    130                 135                 140                 
Asn Val Ser Ser Gly Val Phe Lys Asp Phe Met Asp Glu Lys Gly Lys
145                 150                 155                 160 
Phe Lys Glu Ser Leu Cys Asn Asp Ala Gln Gly Ile Leu Ala Leu Tyr
                165                 170                 175     
Glu Ala Ala Phe Met Arg Val Glu Asp Glu Thr Ile Leu Asp Asn Ala
            180                 185                 190         
Leu Glu Phe Thr Lys Val His Leu Asp Ile Ile Ala Lys Asp Pro Ser
        195                 200                 205             
Cys Asp Ser Ser Leu Arg Thr Gln Ile His Gln Ala Leu Lys Gln Pro
    210                 215                 220                 
Leu Arg Arg Arg Leu Ala Arg Ile Glu Ala Leu His Tyr Met Pro Ile
225                 230                 235                 240 
Tyr Gln Gln Glu Thr Ser His Asn Glu Asp Leu Leu Lys Leu Ala Lys
                245                 250                 255     
Leu Asp Phe Ser Val Leu Gln Ser Met His Lys Lys Glu Leu Ser His
            260                 265                 270         
Ile Cys Lys Trp Trp Lys Asp Leu Asp Leu Gln Asn Lys Leu Pro Tyr
        275                 280                 285             
Val Arg Asp Arg Val Val Glu Gly Tyr Phe Trp Ile Leu Ser Ile Tyr
    290                 295                 300                 
Tyr Glu Pro Gln His Ala Arg Thr Arg Met Phe Leu Met Lys Thr Cys
305                 310                 315                 320 
Met Trp Leu Val Val Leu Asp Asp Thr Phe Asp Asn Tyr Gly Thr Tyr
                325                 330                 335     
Glu Glu Leu Glu Ile Phe Thr Gln Ala Val Glu Arg Trp Ser Ile Ser
            340                 345                 350         
Cys Leu Asp Met Leu Pro Glu Tyr Met Lys Leu Ile Tyr Gln Glu Leu
        355                 360                 365             
Val Asn Leu His Val Glu Met Glu Glu Ser Leu Gly Lys Gly Gly Lys
    370                 375                 380                 
Asn Ile Ser Asn Ser Leu Cys Gln Gly Arg Trp Gln Lys Glu Leu Gly
385                 390                 395                 400 
Ser Gln Ile Thr Leu Val Glu Thr Lys Met Ala Lys Arg Gly Val His
                405                 410                 415     
Ala Gln Pro Leu Glu Glu Tyr Met Ser Val Ser Met Val Thr Gly Thr
            420                 425                 430         
Tyr Gly Leu Met Ile Ala Arg Ser Tyr Val Gly Arg Gly Asp Ile Val
        435                 440                 445             
Thr Glu Asp Thr Phe Lys Trp Val Ser Ser Tyr Pro Pro Ile Ile Lys
    450                 455                 460                 
Ala Ser Cys Val Ile Val Arg Leu Met Asp Asp Ile Val Ser His Lys
465                 470                 475                 480 
Glu Glu Gln Glu Arg Gly His Val Ala Ser Ser Ile Glu Cys Tyr Ser
                485                 490                 495     
Lys Glu Ser Gly Ala Ser Glu Glu Glu Ala Cys Glu Tyr Ile Ser Arg
            500                 505                 510         
Lys Val Glu Asp Ala Trp Lys Val Ile Asn Arg Glu Ser Leu Arg Pro
        515                 520                 525             
Thr Ala Val Pro Phe Pro Leu Leu Met Pro Ala Ile Asn Leu Ala Arg
    530                 535                 540                 
Met Cys Glu Val Leu Tyr Ser Val Asn Asp Gly Phe Thr His Ala Glu
545                 550                 555                 560 
Gly Asp Met Lys Ser Tyr Met Lys Ser Phe Phe Val His Pro Met Val
                565                 570                 575     
Val
    


<210> 378
<211> 549
<212> PRT
<213> Artemisia annua

<220> 
<223> putative sesquiterpene cyclase Acc. No. CAC12732

<400> 378
Met Ser Val Lys Glu Glu Lys Val Ile Arg Pro Ile Val His Phe Pro
 1               5                  10                  15      
Pro Ser Val Trp Ala Asp Gln Phe Leu Ile Phe Asp Asp Lys Gln Ala
            20                  25                  30          
Glu Gln Ala Asn Val Glu Gln Val Val Asn Glu Leu Arg Glu Asp Val
        35                  40                  45              
Arg Lys Asp Leu Val Ser Ser Leu Asp Val Gln Thr Glu His Thr Asn
    50                  55                  60                  
Leu Leu Lys Leu Ile Asp Ala Ile Gln Arg Leu Gly Ile Ala Tyr His
65                  70                  75                  80  
Phe Glu Glu Glu Ile Glu Gln Ala Leu Gln His Ile Tyr Asp Thr Tyr
                85                  90                  95      
Gly Asp Asp Trp Lys Gly Arg Ser Pro Ser Leu Trp Phe Arg Ile Leu
            100                 105                 110         
Arg Gln Gln Gly Phe Tyr Val Ser Cys Asp Ile Phe Lys Asn Tyr Lys
        115                 120                 125             
Lys Glu Asp Gly Ser Ile Leu Arg Asn Pro Leu Thr Asn Asp Val Glu
    130                 135                 140                 
Gly Leu Leu Glu Leu Tyr Glu Ala Thr Tyr Leu Arg Val Gln Gly Glu
145                 150                 155                 160 
Gly Val Leu Asp Asp Ala Leu Val Phe Thr Arg Thr Cys Leu Glu Lys
                165                 170                 175     
Ile Ala Lys Asp Leu Val His Thr Asn Pro Thr Leu Ser Thr Tyr Ile
            180                 185                 190         
Gln Glu Ala Leu Lys Gln Pro Leu Gln Lys Arg Leu Ala Arg Leu Glu
        195                 200                 205             
Ala Leu His Tyr Ile Pro Met Tyr Glu Gln Gln Ala Ser His Asn Glu
    210                 215                 220                 
Ser Leu Leu Lys Leu Ala Lys Leu Gly Phe Asn Leu Leu Gln Ser Leu
225                 230                 235                 240 
His Arg Lys Glu Leu Asn Glu Val Ser Arg Trp Trp Lys Gly Leu Asp
                245                 250                 255     
Val Pro Asn Asn Leu Pro Tyr Ala Arg Asp Arg Met Val Glu Cys Tyr
            260                 265                 270         
Phe Trp Ala Leu Gly Val Tyr Phe Glu Pro Lys Tyr Ser Gln Ala Arg
        275                 280                 285             
Ile Phe Leu Ala Lys Val Ile Ser Leu Ala Thr Val Leu Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Tyr Glu Glu Leu Lys Ile Phe Thr Glu Ala
305                 310                 315                 320 
Ile Gln Arg Trp Ser Ile Thr Cys Ile Asp Met Leu Pro Glu Tyr Leu
                325                 330                 335     
Lys Leu Leu Tyr Gln Gly Val Leu Asp Ile Tyr Ile Glu Met Glu Glu
            340                 345                 350         
Ile Met Gly Lys Glu Gly Lys Ala His His Leu Ser Tyr Ala Lys Glu
        355                 360                 365             
Ser Met Lys Glu Phe Ile Arg Ser Tyr Met Met Glu Ala Lys Trp Ala
    370                 375                 380                 
Asn Glu Gly Tyr Val Pro Thr Ala Glu Glu His Met Ser Val Ala Phe
385                 390                 395                 400 
Val Ser Ser Gly Tyr Ser Met Leu Ala Thr Thr Cys Phe Val Gly Met
                405                 410                 415     
Gly Asp Ile Val Thr Asp Glu Ala Phe Lys Trp Ala Leu Thr Lys Pro
            420                 425                 430         
Pro Ile Ile Lys Ala Ser Cys Ala Ile Ala Arg Leu Met Asp Asp Ile
        435                 440                 445             
His Ser Gln Lys Glu Glu Lys Glu Arg Ile His Val Ala Ser Ser Val
    450                 455                 460                 
Glu Ser Tyr Met Lys Gln Tyr Asp Val Thr Glu Glu His Val Leu Lys
465                 470                 475                 480 
Val Phe Asn Lys Lys Ile Glu Asp Ala Trp Lys Asp Ile Thr Arg Glu
                485                 490                 495     
Ser Leu Val Arg Lys Asp Ile Pro Met Pro Leu Met Met Arg Val Ile
            500                 505                 510         
Asn Leu Ala Gln Val Met Asp Val Leu Tyr Lys His Lys Asp Gly Phe
        515                 520                 525             
Thr Asn Val Gly Glu Glu Leu Lys Asp His Ile Lys Ser Leu Leu Val
    530                 535                 540                 
His Pro Ile Pro Ile
545                 


<210> 379
<211> 582
<212> PRT
<213> Artemisia annua

<220> 
<223> (-)-beta-pinene synthase Acc. No. AAK58723

<400> 379
Met Ala Ser Met Cys Thr Phe Ser Ser Pro Phe Leu Leu Cys Asn Ser
 1               5                  10                  15      
Ser Ile Ser Arg Thr Asn Ile Val Ala Cys Asn Lys Gln Thr Ser Thr
            20                  25                  30          
Leu Gln Ala Gln Val Lys Asn Val Ala Thr Ile Glu Thr Thr Asn Arg
        35                  40                  45              
Arg Ser Ala Asn Tyr Ala Pro Ser Leu Trp Ser Tyr Asp Phe Val Gln
    50                  55                  60                  
Ser Leu Ser Ser Lys Tyr Lys Gly Asp Asn Tyr Met Ala Arg Ser Arg
65                  70                  75                  80  
Ala Leu Lys Gly Val Val Arg Thr Met Ile Leu Glu Ala Asn Gly Ile
                85                  90                  95      
Glu Asn Pro Leu Ser Leu Leu Asn Leu Val Asp Asp Leu Gln Arg Leu
            100                 105                 110         
Gly Ile Ser Tyr His Phe Leu Asp Glu Ile Ser Asn Val Leu Glu Lys
        115                 120                 125             
Ile Tyr Leu Asn Phe Tyr Lys Ser Pro Glu Lys Trp Thr Asn Met Asp
    130                 135                 140                 
Leu Asn Leu Arg Ser Leu Gly Phe Arg Leu Leu Arg Gln His Gly Tyr
145                 150                 155                 160 
His Ile Pro Gln Glu Ile Phe Lys Asp Phe Ile Asp Val Asn Gly Asn
                165                 170                 175     
Phe Lys Gly Asp Ile Ile Ser Met Leu Asn Leu Tyr Glu Ala Ser Tyr
            180                 185                 190         
His Ser Val Glu Glu Glu Ser Ile Leu Asp Asp Ala Arg Glu Phe Thr
        195                 200                 205             
Thr Lys Tyr Leu Lys Glu Thr Leu Glu Asn Ile Glu Asp Gln Asn Ile
    210                 215                 220                 
Ala Leu Phe Ile Ser His Ala Leu Val Phe Pro Leu His Trp Met Val
225                 230                 235                 240 
Pro Arg Val Glu Thr Ser Trp Phe Ile Glu Val Tyr Pro Lys Lys Val
                245                 250                 255     
Gly Met Asn Pro Thr Val Leu Glu Phe Ala Lys Leu Asp Phe Asn Ile
            260                 265                 270         
Leu Gln Ala Val His Gln Glu Asp Met Lys Lys Ala Ser Arg Trp Trp
        275                 280                 285             
Lys Glu Thr Cys Trp Glu Lys Phe Gly Phe Ala Arg Asp Arg Leu Val
    290                 295                 300                 
Glu Asn Phe Met Trp Thr Val Ala Glu Asn Tyr Leu Pro His Phe Gln
305                 310                 315                 320 
Thr Gly Arg Gly Val Leu Thr Lys Val Asn Ala Met Ile Thr Thr Ile
                325                 330                 335     
Asp Asp Val Tyr Asp Val Tyr Gly Thr Leu Pro Glu Leu Glu Leu Phe
            340                 345                 350         
Thr Asn Ile Val Asn Ser Trp Asp Ile Asn Ala Ile Asp Glu Leu Pro
        355                 360                 365             
Asp Tyr Leu Lys Ile Cys Phe Leu Ala Cys Tyr Asn Ala Thr Asn Glu
    370                 375                 380                 
Leu Ser Tyr Asn Thr Leu Thr Asn Lys Gly Phe Phe Val His Pro Tyr
385                 390                 395                 400 
Leu Lys Lys Ala Trp Gln Asp Leu Cys Asn Ser Tyr Ile Ile Glu Ala
                405                 410                 415     
Lys Trp Phe Asn Asp Gly Tyr Thr Pro Thr Phe Asn Glu Phe Ile Glu
            420                 425                 430         
Asn Ala Tyr Met Ser Ile Gly Ile Ala Pro Ile Ile Arg His Ala Tyr
        435                 440                 445             
Leu Leu Thr Leu Thr Ser Val Thr Glu Glu Ala Leu Gln His Ile Glu
    450                 455                 460                 
Arg Ala Glu Ser Met Ile Arg Asn Ala Cys Leu Ile Val Arg Leu Thr
465                 470                 475                 480 
Asn Asp Met Gly Thr Ser Ser Asp Glu Leu Glu Arg Gly Asp Ile Pro
                485                 490                 495     
Lys Ser Ile Gln Cys Tyr Met His Glu Ser Gly Ala Thr Glu Met Glu
            500                 505                 510         
Ala Arg Ala Tyr Ile Lys Gln Phe Ile Val Glu Thr Trp Lys Lys Leu
        515                 520                 525             
Asn Lys Glu Arg Gln Glu Ile Gly Ser Glu Phe Pro Gln Glu Phe Val
    530                 535                 540                 
Asp Cys Val Ile Asn Leu Pro Arg Met Gly His Phe Met Tyr Thr Asp
545                 550                 555                 560 
Gly Asp Lys His Gly Lys Pro Asp Met Phe Lys Pro Tyr Val Phe Ser
                565                 570                 575     
Leu Phe Val Asn Pro Ile
            580         


<210> 380
<211> 573
<212> PRT
<213> Artemisia annua

<220> 
<223> sesquiterpene cyclase Acc. No. AAG24640

<400> 380
Met Ser Thr Phe Leu Val Cys Asn Ala Ser Phe Ser Pro Ser Tyr Gly
 1               5                  10                  15      
Leu Pro Ser Ser Cys Asp Arg Asn Ser Ser Met Asn Gln Glu Ile Val
            20                  25                  30          
Arg Asn Thr Val Lys Phe Pro Pro Ser Ile Trp Gly Asp Gln Phe Leu
        35                  40                  45              
Thr Tyr His Glu Pro Lys Lys Ser Leu Thr Ile Glu Lys Gln His Val
    50                  55                  60                  
Glu Glu Val Glu Glu Ile Arg Lys Lys Leu Leu Asn Thr Ala Phe Ser
65                  70                  75                  80  
Glu Pro Lys Gln His Thr Lys Leu Ile His Leu Ile Asp Ser Val Gln
                85                  90                  95      
Arg Leu Gly Val Ser Tyr His Phe Glu Gln Glu Ile Glu Glu Ala Leu
            100                 105                 110         
Gln His Val Tyr Ala Thr His Gly Asp Gln Trp Ile Gly Lys Asp Asn
        115                 120                 125             
Leu Lys Ser Thr Ser Gln Trp Phe Arg Ile Leu Arg Gln Gln Gly Phe
    130                 135                 140                 
Asn Val Ser Ser Gly Ile Phe Glu Asn His Met Asp Asp Lys Gly Lys
145                 150                 155                 160 
Phe Lys Glu His Leu Ser Asp Asp Val Gln Gly Met Leu Gly Leu Tyr
                165                 170                 175     
Glu Ala Ala Tyr Met Ser Val Glu Gly Glu Lys Glu Leu Asp Asp Ala
            180                 185                 190         
Leu Glu Phe Thr Lys Thr His Leu Gly Asn Ile Ala Lys Asp Pro Ser
        195                 200                 205             
Gln Asn Ala Ser Leu Arg Thr Lys Ile Glu Gln Ala Leu Asn Arg Pro
    210                 215                 220                 
Leu Arg Lys Arg Met Pro Arg Leu Glu Ala Leu His Tyr Ile Pro Lys
225                 230                 235                 240 
Tyr Gln Gln Glu Ala Ser His Asp Glu Thr Leu Leu Asn Leu Ala Lys
                245                 250                 255     
Leu Asp Tyr Asn Met Leu Gln Ser Ile His Lys Arg Glu Ile Ser Glu
            260                 265                 270         
Ile Cys Lys Trp Trp Lys Asp Leu Asp Phe Ser Asn Lys Leu Pro His
        275                 280                 285             
Val Arg Asp Arg Leu Val Glu Ile Tyr Phe Trp Val Leu Gly Val Tyr
    290                 295                 300                 
Phe Glu Pro Gln His Tyr Arg Ser Arg Met Phe Leu Thr Lys Thr Ser
305                 310                 315                 320 
Met Trp Leu Ile Val Leu Asp Asp Thr Tyr Asp Asn Tyr Gly Thr Tyr
                325                 330                 335     
Glu Glu Leu Lys Ile Phe Thr Glu Ala Val Gln Arg Trp Ser Leu Ser
            340                 345                 350         
Cys Leu Asp Ser Leu Pro Glu Tyr Met Lys Leu Ile Tyr Arg Glu Leu
        355                 360                 365             
Ile Asn His Tyr Gln Glu Met Glu Glu Ser Val Glu Lys Glu Gly Lys
    370                 375                 380                 
Ser Tyr Gln Leu Phe Tyr Ala Lys Glu Met Val Lys Glu Asn Cys Arg
385                 390                 395                 400 
Asn Leu Leu Val Glu Ala Lys Trp Leu Lys Glu Gly Tyr Val Pro Thr
                405                 410                 415     
Leu Glu Glu His Met Ser Val Ser Cys Val Thr Tyr Ala Tyr Ala Val
            420                 425                 430         
Met Ile Ala Asn Ser Tyr Val Gly Arg Glu Asn Met Val Thr Glu Glu
        435                 440                 445             
Ser Phe Lys Trp Val Ala Lys Phe Pro Pro Leu Val Asn Ala Thr Cys
    450                 455                 460                 
Leu Ile Leu Arg Leu Met Asp Asp Ile Ala Gly His Glu Glu Glu Gln
465                 470                 475                 480 
Glu Arg Asp His Val Val Ser Ser Ile Glu Cys Tyr Arg Asn Glu Thr
                485                 490                 495     
Gly Ala Ser Glu Glu Asp Ala Val Lys Phe Leu Ser Lys Gln Val Glu
            500                 505                 510         
Asp Ala Trp Lys Val Ile Asn Lys Glu Cys Leu Arg Pro Thr Glu Ile
        515                 520                 525             
Pro Met Ser Leu Thr Ile Pro Pro Leu Ser Leu Ala Arg Val Ser Asp
    530                 535                 540                 
Ile Leu Tyr Lys Thr Asn Asn Gly Tyr Asn His Ala Gly Glu Glu Val
545                 550                 555                 560 
Ile Ser Tyr Ile Lys Ser Leu Leu Val His Pro Leu Val
                565                 570             


<210> 381
<211> 546
<212> PRT
<213> Artemisia annua

<220> 
<223> amorpha-4,11-diene synthase Acc. No. AAK15696

<400> 381
Met Ser Leu Thr Glu Glu Lys Pro Ile Arg Pro Ile Ala Asn Phe Pro
 1               5                  10                  15      
Pro Ser Ile Trp Gly Asp Gln Phe Leu Ile Tyr Glu Lys Gln Val Glu
            20                  25                  30          
Gln Gly Val Glu Gln Ile Val Asn Asp Leu Lys Lys Glu Val Arg Gln
        35                  40                  45              
Leu Leu Lys Glu Ala Leu Asp Ile Pro Met Lys His Ala Asn Leu Leu
    50                  55                  60                  
Lys Leu Ile Asp Glu Ile Gln Arg Leu Gly Ile Pro Tyr His Phe Glu
65                  70                  75                  80  
Gln Glu Ile Asp His Ala Leu Gln Cys Ile Tyr Glu Thr Tyr Gly Asp
                85                  90                  95      
Asn Trp Asp Gly Asp Arg Ser Ser Leu Trp Phe Arg Leu Met Arg Lys
            100                 105                 110         
Gln Gly Tyr Tyr Val Thr Cys Asp Val Phe Asn Asn Tyr Lys Asp Lys
        115                 120                 125             
Asp Gly Ala Phe Lys Gln Ser Leu Ala Asn Asp Val Glu Gly Leu Leu
    130                 135                 140                 
Glu Leu Tyr Glu Ala Thr Ser Met Arg Val Pro Gly Glu Ile Met Leu
145                 150                 155                 160 
Glu Asp Ala Leu Gly Phe Thr Arg Ser Arg Leu Ser Ile Met Thr Lys
                165                 170                 175     
Asp Ala Phe Ser Thr Asn Pro Ala Leu Phe Thr Glu Ile Gln Arg Ala
            180                 185                 190         
Leu Lys Gln Pro Leu Trp Lys Arg Leu Pro Arg Ile Glu Ala Ala Gln
        195                 200                 205             
Tyr Ile Pro Phe Tyr Gln Gln Gln Asp Ser His Asn Lys Thr Leu Leu
    210                 215                 220                 
Lys Leu Ala Lys Leu Glu Phe Asn Leu Leu Gln Ser Leu His Lys Glu
225                 230                 235                 240 
Glu Leu Ser His Val Cys Lys Trp Trp Lys Ala Phe Asp Ile Lys Lys
                245                 250                 255     
Asn Ala Pro Cys Leu Arg Asp Arg Ile Val Glu Cys Tyr Phe Trp Gly
            260                 265                 270         
Leu Gly Ser Gly Phe Glu Pro Gln Tyr Ser Arg Ala Arg Val Phe Phe
        275                 280                 285             
Thr Lys Ala Val Ala Val Ile Thr Leu Ile Asp Asp Thr Tyr Asp Ala
    290                 295                 300                 
Tyr Gly Thr Tyr Glu Glu Leu Lys Ile Phe Thr Glu Ala Val Glu Arg
305                 310                 315                 320 
Trp Ser Ile Thr Cys Leu Asp Thr Leu Pro Glu Tyr Met Lys Pro Ile
                325                 330                 335     
Tyr Lys Leu Phe Met Asp Thr Tyr Thr Glu Met Glu Glu Phe Leu Ala
            340                 345                 350         
Lys Glu Gly Arg Thr Asp Leu Phe Asn Cys Gly Lys Glu Phe Val Lys
        355                 360                 365             
Glu Phe Val Arg Asn Leu Met Val Glu Ala Lys Trp Ala Asn Glu Gly
    370                 375                 380                 
His Ile Pro Thr Thr Glu Glu His Asp Pro Val Val Ile Ile Thr Gly
385                 390                 395                 400 
Gly Ala Asn Leu Leu Thr Thr Thr Cys Tyr Leu Gly Met Ser Asp Ile
                405                 410                 415     
Phe Thr Lys Glu Ser Val Glu Trp Ala Val Ser Ala Pro Pro Leu Phe
            420                 425                 430         
Arg Tyr Ser Gly Ile Leu Gly Arg Arg Leu Asn Asp Leu Met Thr His
        435                 440                 445             
Lys Ala Glu Gln Glu Arg Lys His Ser Ser Ser Ser Leu Glu Ser Tyr
    450                 455                 460                 
Met Lys Glu Tyr Asn Val Asn Glu Glu Tyr Ala Gln Thr Leu Ile Tyr
465                 470                 475                 480 
Lys Glu Val Glu Asp Val Trp Lys Asp Ile Asn Arg Glu Tyr Leu Thr
                485                 490                 495     
Thr Lys Asn Ile Pro Arg Pro Leu Leu Met Ala Val Ile Tyr Leu Cys
            500                 505                 510         
Gln Phe Leu Glu Val Gln Tyr Ala Gly Lys Asp Asn Phe Thr Arg Met
        515                 520                 525             
Gly Asp Glu Tyr Lys His Leu Ile Lys Ser Leu Leu Val Tyr Pro Met
    530                 535                 540                 
Ser Ile
545     


<210> 382
<211> 567
<212> PRT
<213> Artemisia annua

<220> 
<223> (3R)-linalool synthase Acc. No. AAF13357

<400> 382
Gly Asn Ala Tyr Met Arg Ile Tyr Ser Thr Lys Thr Thr Arg Ile Thr
 1               5                  10                  15      
Ala Asn Ala Thr Val Asn Ala Ala Asp Thr His Val Arg Arg Ser Ala
            20                  25                  30          
Asn Tyr Lys Pro Ser Ser Trp Ser Phe Asp His Ile Gln Ser Leu Ser
        35                  40                  45              
Ser Lys Tyr Thr Gly Asp Asp Tyr Val Ala Arg Ala Asn Thr Leu Lys
    50                  55                  60                  
Asp Ala Val Lys Thr Met Ile Arg Lys Ser Gly Asn Ser Leu Arg Thr
65                  70                  75                  80  
Leu Glu Leu Val Asp Glu Leu Gln Arg Leu Gly Ile Ser Tyr Leu Phe
                85                  90                  95      
Glu Glu Glu Ile Ser Asn Leu Leu Glu Thr Ile Tyr Tyr Asn Tyr Tyr
            100                 105                 110         
Lys Phe Pro Glu Asn Trp Asn Lys Ile Asn Leu Asn Leu Lys Ala Leu
        115                 120                 125             
Gly Phe Arg Leu Leu Arg Gln His Gly Tyr His Val Pro Gln Glu Ile
    130                 135                 140                 
Phe Leu Asn Phe Lys Asp Lys Asn Gln Asn Leu Asn Ser Tyr Leu Leu
145                 150                 155                 160 
Asn Asp Val Val Glu Met Leu Asn Leu Tyr Glu Ala Ser Tyr His Ser
                165                 170                 175     
Phe Glu Asp Glu Ser Ile Leu Asp Asp Ala Arg Asp Ile Thr Thr Lys
            180                 185                 190         
Tyr Leu Lys Glu Ser Leu Glu Lys Ile Asp Gly Ser Ile Phe Ser Ser
        195                 200                 205             
Val Thr His Ala Leu Glu Gln Pro Leu His Trp Arg Val Pro Arg Val
    210                 215                 220                 
Glu Ala Lys Trp Phe Ile Glu Leu Tyr Glu Lys Lys Asn Gly Met Ser
225                 230                 235                 240 
Pro Thr Leu Val Glu Leu Ala Lys Leu Asp Phe Asp Met Val Gln Ala
                245                 250                 255     
Ile His Leu Glu Asp Leu Lys His Ala Ser Arg Trp Trp Arg Asp Thr
            260                 265                 270         
Ser Trp Asp Thr Lys Leu Thr Phe Ala Arg Asp Leu Ile Val Glu Asn
        275                 280                 285             
Phe Leu Trp Thr Ile Gly Phe Ser Tyr Leu Pro Asn Phe Ser Arg Gly
    290                 295                 300                 
Arg Arg Thr Ile Thr Lys Val Ala Val Met Ile Thr Thr Leu Asp Asp
305                 310                 315                 320 
Val Tyr Asp Val Phe Gly Thr Leu Gly Glu Leu Glu Gln Phe Thr Asp
                325                 330                 335     
Val Ile Asn Arg Trp Asp Ile Lys Ala Ile Glu Gln Leu Pro Asp Tyr
            340                 345                 350         
Met Lys Ile Cys Phe Leu Gly Leu Tyr Lys Ser Ile Asn Asp Ile Thr
        355                 360                 365             
His Glu Thr Leu Ala Asn Lys Gly Phe Leu Ile Leu Pro Tyr Leu Lys
    370                 375                 380                 
Lys Ala Trp Ala Asp Leu Cys Lys Ala Tyr Leu Val Glu Ala Gln Trp
385                 390                 395                 400 
Tyr His Arg Gly His Ile Pro Thr Leu Asn Glu Tyr Leu Asp Asn Ala
                405                 410                 415     
Cys Val Ser Ile Ser Gly Pro Val Ala Leu Met His Val His Phe Leu
            420                 425                 430         
Thr Ser Val Ser Ser Ile Glu Glu Ile His Gln Cys Ile Gln Arg Thr
        435                 440                 445             
Glu Asn Ile Val His Tyr Val Ser Leu Ile Phe Arg Leu Ala Asp Asp
    450                 455                 460                 
Leu Gly Thr Ser Leu Gly Glu Met Glu Arg Gly Asp Thr Leu Lys Ser
465                 470                 475                 480 
Ile Gln Leu His Met His Glu Thr Gly Ala Thr Glu Pro Glu Ala Arg
                485                 490                 495     
Ser Tyr Ile Lys Leu Leu Ile Asn Lys Thr Trp Lys Lys Leu Asn Lys
            500                 505                 510         
Glu Arg Ala Thr Val Asn Ser Glu Ser Ser Gln Glu Phe Ile Asp Tyr
        515                 520                 525             
Ala Thr Asn Leu Val Arg Met Ala Gln Phe Met Tyr Gly Glu Gly Asp
    530                 535                 540                 
Glu Asp Phe Gly Leu Asp Val Ile Lys Ser His Val Leu Ser Leu Leu
545                 550                 555                 560 
Phe Thr Pro Ile Gln Gly Ile
                565         


<210> 383
<211> 562
<212> PRT
<213> Artemisia annua

<220> 
<223> germacrene A synthase Acc. No. ABE03980

<400> 383
Met Ala Ala Val Gln Ala Asn Val Thr Gly Ile Lys Ala Asn Thr Lys
 1               5                  10                  15      
Thr Ser Ala Glu Pro Val Arg Pro Leu Ala Asn Phe Pro Pro Ser Val
            20                  25                  30          
Trp Gly Asp Arg Phe Leu Ser Phe Ser Leu Asp Arg Ser Glu Leu Glu
        35                  40                  45              
Arg Tyr Ala Ile Ala Met Glu Lys Pro Lys Glu Asp Leu Arg Lys Leu
    50                  55                  60                  
Ile Val Asp Pro Thr Met Asp Ser Asn Glu Lys Leu Gly Leu Ile Tyr
65                  70                  75                  80  
Ser Val His Arg Leu Gly Leu Thr Tyr Met Phe Leu Gln Glu Ile Glu
                85                  90                  95      
Ser Gln Leu Asp Lys Leu Phe Asn Lys Phe Ser Leu Gln Asp Tyr Glu
            100                 105                 110         
Glu Val Asp Leu Tyr Thr Ile Ser Ile Asn Phe Gln Val Phe Arg His
        115                 120                 125             
Val Gly Tyr Lys Leu Pro Cys Asp Val Phe Asn Lys Phe Lys Asp Val
    130                 135                 140                 
Ser Ser Gly Thr Phe Lys Ala Ser Ile Thr Ser Asp Val Gly Val Val
145                 150                 155                 160 
Gly Leu Tyr Glu Ser Ala Gln Leu Arg Ile Arg Gly Glu Lys Ile Leu
                165                 170                 175     
Asp Glu Ala Ser Val Phe Thr Glu Ala Lys Leu Lys Ser Val Val Asn
            180                 185                 190         
Thr Leu Glu Gly Asp Leu Ala Gln Gln Val Thr Gln Ser Leu Arg Arg
        195                 200                 205             
Pro Phe His Gln Gly Met Pro Leu Gly Ile Arg Gln Gly Ser Ile Ser
    210                 215                 220                 
Leu Thr Met Lys Lys Asn Val Pro Leu Met Thr His Cys Leu Lys Leu
225                 230                 235                 240 
Ala Lys Leu His Phe Lys Tyr Leu Glu Leu Gln Gln Lys Glu Glu Leu
                245                 250                 255     
Arg Ile Val Ser Lys Trp Trp Lys Asp Met Arg Phe His Glu Thr Thr
            260                 265                 270         
Pro Tyr Ile Arg Asp Arg Val Pro Glu Ile Tyr Leu Trp Ile Leu Gly
        275                 280                 285             
Leu Tyr Phe Glu Pro Arg Tyr Ser Leu Ala Arg Ile Ile Ala Thr Lys
    290                 295                 300                 
Ile Thr Leu Phe Leu Val Val Leu Asp Asp Thr Tyr Asp Ala Tyr Ala
305                 310                 315                 320 
Thr Ile Glu Glu Ile Arg Leu Leu Thr Asp Ala Ile Asn Lys Trp Asp
                325                 330                 335     
Ile Ser Ala Met Glu Gln Ile Pro Glu Tyr Ile Arg Pro Phe Tyr Lys
            340                 345                 350         
Ile Leu Leu Asp Glu Tyr Ala Gly Asn Trp Arg Arg Lys Trp Leu Lys
        355                 360                 365             
Lys Gly Glu Gln Ile Leu Leu Leu Leu Gln Lys Lys Arg Ser Lys Thr
    370                 375                 380                 
Leu Ala Arg Gly Tyr Leu Glu Glu Ala Glu Trp Thr Asn Ser Gly Tyr
385                 390                 395                 400 
Val Ala Ser Phe Pro Glu Tyr Met Lys Asn Gly Leu Ile Thr Ser Ala
                405                 410                 415     
Tyr Asn Val Ile Ser Lys Ser Ala Leu Val Gly Met Gly Glu Ile Val
            420                 425                 430         
Ser Glu Asp Ala Leu Ala Trp Tyr Glu Ser His Pro Lys Thr Leu Gln
        435                 440                 445             
Ala Ser Glu Leu Ile Ser Arg Leu Gln Asp Asp Val Met Thr Tyr Gln
    450                 455                 460                 
Phe Glu Arg Glu Arg Gly Gln Ser Ala Thr Gly Val Asp Ala Tyr Ile
465                 470                 475                 480 
Lys Thr Tyr Gly Val Ser Glu Lys Glu Ala Ile Asp Ala Leu Lys Ile
                485                 490                 495     
Met Ile Glu Asn Ala Trp Lys Asp Ile Asn Glu Gly Cys Leu Lys Pro
            500                 505                 510         
Arg Gln Val Ser Met Asp Leu Leu Ala Pro Ile Leu Asn Leu Ala Arg
        515                 520                 525             
Met Ile Asp Val Val Tyr Arg Tyr Asp Asp Gly Phe Thr Phe Pro Arg
    530                 535                 540                 
Lys Asp Ser Glu Arg Val Tyr Gln Ser Phe Cys Leu Trp Val Leu Tyr
545                 550                 555                 560 
Pro Val
        


<210> 384
<211> 559
<212> PRT
<213> Capsicum annuum

<220> 
<223> sesquiterpene cyclase Acc. No. AAC61260

<400> 384
Met Ala Ser Val Ala Val Glu Asn Asn Val Val Asn His Ile Ala Glu
 1               5                  10                  15      
Glu Ile Ile Arg Pro Val Ala Asp Phe Ser Pro Ser Leu Trp Gly Asp
            20                  25                  30          
Arg Phe Leu Ser Phe Ser Ile Asp Asn Gln Val Glu Thr Lys Tyr Ala
        35                  40                  45              
Gln Glu Ile Glu Pro Leu Lys Glu Gln Thr Arg Ser Met Leu Leu Ala
    50                  55                  60                  
Ser Gly Arg Lys Leu Ser Glu Thr Leu Asn Leu Ile Asp Val Ile Glu
65                  70                  75                  80  
Arg Leu Gly Ile Ala Tyr His Phe Glu Lys Glu Ile Asp Glu Ile Leu
                85                  90                  95      
Asp Arg Ile Tyr Asn Glu Asn Ser Asn Phe Glu Gly Asp Val Tyr Asn
            100                 105                 110         
Glu Asp Leu Cys Thr Cys Arg Leu Gln Phe Arg Leu Leu Arg Gln His
        115                 120                 125             
Gly Tyr Asn Ile Ser Leu Lys Ile Phe Ser Lys Phe Leu Asp Gly Asn
    130                 135                 140                 
Gly Arg Leu Lys Glu Ser Leu Ala Ser Asp Val Leu Gly Leu Leu Ser
145                 150                 155                 160 
Leu Tyr Glu Ala Ser His Val Arg Ser His Gly Glu Asp Ile Leu Glu
                165                 170                 175     
Asp Ala Leu Ala Phe Ser Thr Thr His Leu Glu Ser Ala Thr Pro His
            180                 185                 190         
Leu Glu Tyr Pro Leu Lys Glu Gln Val Arg His Ala Leu Glu Gln Ser
        195                 200                 205             
Leu His Lys Gly Ile Pro Arg Ile Glu Ile Gln Phe Phe Ile Ser Ser
    210                 215                 220                 
Val Tyr Asp Lys Gln Ala Ile Lys Asn Asp Val Leu Leu Arg Phe Ala
225                 230                 235                 240 
Lys Leu Asp Tyr Asn Met Leu Gln Met Leu His Lys Gln Glu Leu Ala
                245                 250                 255     
Glu Val Ser Arg Trp Trp Lys Asp Leu Asn Phe Val Asn Thr Leu Pro
            260                 265                 270         
Tyr Ala Arg Asp Arg Val Val Glu Cys Tyr Phe Trp Ala Leu Gly Val
        275                 280                 285             
Tyr Tyr Glu Pro Gln Tyr Ser Gln Ala Arg Val Met Leu Val Lys Thr
    290                 295                 300                 
Ile Ala Met Ile Ser Ile Val Asp Asp Thr Tyr Asp Ala Tyr Gly Thr
305                 310                 315                 320 
Val Asp Glu Leu Ala Ile Tyr Thr Asp Val Ile Gln Arg Trp Asp Ile
                325                 330                 335     
Lys Glu Ile Asp Ser Leu Pro Asp Tyr Met Lys Ile Ser Tyr Lys Ala
            340                 345                 350         
Leu Leu Asp Leu Tyr Lys Asp Tyr Glu Lys Glu Met Ser Arg Asp Gly
        355                 360                 365             
Arg Ser His Val Val Tyr Tyr Ala Lys Glu Arg Leu Lys Glu Leu Val
    370                 375                 380                 
Lys Ser Tyr Asn Ile Glu Ala Lys Trp Phe Ile Glu Gly His Met Pro
385                 390                 395                 400 
Pro Ala Ser Glu Tyr Leu Arg Asn Ala Phe Val Thr Thr Thr Tyr Tyr
                405                 410                 415     
Tyr Leu Ala Thr Thr Ser Tyr Leu Gly Met Lys Tyr Ala Lys Glu Gln
            420                 425                 430         
Gln Phe Glu Trp Leu Ser Lys Asn Pro Lys Ile Leu Glu Gly Cys Val
        435                 440                 445             
Thr Ile Cys Arg Val Ile Asp Asp Ile Ala Thr Tyr Glu Val Glu Lys
    450                 455                 460                 
Asn Arg Gly Gln Leu Ser Thr Gly Ile Glu Cys Tyr Met Arg Asp Tyr
465                 470                 475                 480 
Ser Val Ser Thr Lys Glu Ala Met Ala Lys Phe Gln Glu Met Gly Glu
                485                 490                 495     
Ser Gly Trp Lys Asp Ile Asn Glu Gly Met Leu Arg Pro Thr Pro Ile
            500                 505                 510         
Pro Met Glu Phe Leu Ser Arg Ile Leu Asn Leu Ala Arg Leu Val Asp
        515                 520                 525             
Val Thr Tyr Lys His Asn Glu Asp Gly Tyr Thr His Pro Glu Lys Val
    530                 535                 540                 
Ile Lys Pro His Ile Ile Ala Met Val Val Asp Ser Phe Lys Ile
545                 550                 555                 


<210> 385
<211> 559
<212> PRT
<213> Capsicum annuum

<220> 
<223> 5-epi-aristolochene synthase Acc. No. CAA06614

<400> 385
Met Ala Ser Val Ala Val Glu Asn Asn Val Val Asn His Ile Ala Glu
 1               5                  10                  15      
Glu Ile Ile Arg Pro Val Ala Asp Tyr Ser Pro Ser Ile Trp Gly Asp
            20                  25                  30          
Arg Phe Leu Ser Phe Ser Ile Asp Asn Gln Val Glu Gln Lys Tyr Ala
        35                  40                  45              
Gln Glu Ile Glu Pro Pro Lys Glu Gln Thr Arg Ser Met Leu Leu Ala
    50                  55                  60                  
Ser Pro Arg Lys Leu Ser Asp Thr Leu Asn Leu Ile Asp Val Ile Glu
65                  70                  75                  80  
Arg Leu Ala Ile Ala Tyr His Phe Glu Lys Glu Ile Asp Glu Ile Leu
                85                  90                  95      
Asp Arg Ile Tyr Asn Glu Asn Ser Asn Phe Glu Gly Asp Val Tyr Asn
            100                 105                 110         
Glu Asp Leu Cys Thr Cys Ala Leu Gln Phe Arg Leu Leu Arg Gln His
        115                 120                 125             
Gly Tyr Asn Ile Ser Leu Glu Ile Phe Ser Lys Phe Leu Asp Gly Asn
    130                 135                 140                 
Gly Arg Leu Lys Glu Ser Leu Ala Ser Asp Val Leu Gly Leu Leu Ser
145                 150                 155                 160 
Leu Tyr Glu Ala Ser His Val Arg Ser His Gly Glu Asp Ile Leu Glu
                165                 170                 175     
Asp Ala Leu Ala Phe Ser Thr Thr His Leu Glu Ser Ala Thr Pro His
            180                 185                 190         
Leu Glu Tyr Pro Leu Lys Glu Gln Val Arg His Ala Leu Glu Gln Ser
        195                 200                 205             
Leu His Lys Gly Ile Pro Arg Ile Glu Ile Gln Phe Phe Ile Ser Ser
    210                 215                 220                 
Ile Tyr Asp Lys Gln Ala Ile Lys Asn Asp Val Leu Leu Arg Phe Ala
225                 230                 235                 240 
Lys Leu Asp Tyr Asn Met Leu Gln Met Leu His Lys Gln Glu Leu Ala
                245                 250                 255     
Glu Val Ser Arg Trp Trp Lys Asp Leu Asn Phe Val Asn Thr Leu Pro
            260                 265                 270         
Tyr Ala Arg Asp Arg Val Val Glu Cys Tyr Phe Trp Ala Leu Gly Val
        275                 280                 285             
Tyr Tyr Glu Pro Gln Tyr Ser Gln Ala Arg Val Met Leu Val Lys Thr
    290                 295                 300                 
Ile Ala Met Ile Ser Ile Val Asp Asp Thr Tyr Glu Ala Tyr Gly Thr
305                 310                 315                 320 
Val Asp Glu Leu Ala Ile Tyr Thr Asp Val Ile Gln Arg Trp Asp Ile
                325                 330                 335     
Lys Arg Ile Asp Ser Leu Pro Asp Tyr Met Lys Ile Ser Tyr Lys Ala
            340                 345                 350         
Leu Leu Asp Leu Tyr Lys Asp Tyr Glu Lys Glu Met Ser Arg Asp Gly
        355                 360                 365             
Arg Ser His Val Val Tyr Tyr Ala Lys Glu Arg Leu Lys Glu Leu Val
    370                 375                 380                 
Lys Ser Tyr Asn Ile Glu Ala Lys Trp Phe Ile Glu Gly His Met Pro
385                 390                 395                 400 
Pro Ala Ser Glu Tyr Leu Arg Asn Ala Phe Val Thr Thr Thr Tyr Tyr
                405                 410                 415     
Tyr Leu Ala Thr Thr Ser Tyr Leu Gly Met Lys Tyr Ala Lys Glu Gln
            420                 425                 430         
Gln Phe Glu Trp Leu Ser Lys Asn Pro Lys Ile Leu Glu Gly Cys Val
        435                 440                 445             
Thr Ile Cys Arg Val Ile Asp Asp Ile Ala Thr Tyr Glu Val Glu Lys
    450                 455                 460                 
Asn Arg Gly Gln Leu Ser Thr Gly Ile Glu Cys Tyr Met Arg Asp Tyr
465                 470                 475                 480 
Ser Val Ser Thr Lys Glu Ala Met Ala Lys Phe Gln Glu Met Gly Glu
                485                 490                 495     
Ser Gly Trp Lys Asp Ile Asn Glu Gly Met Leu Arg Pro Thr Pro Ile
            500                 505                 510         
Pro Met Glu Phe Leu Ser Arg Ile Leu Asn Leu Ala Arg Leu Val Asp
        515                 520                 525             
Val Thr Tyr Lys His Asn Glu Asp Gly Tyr Thr His Pro Glu Lys Val
    530                 535                 540                 
Ile Lys Pro His Ile Ile Ala Met Val Val Asp Ser Phe Lys Ile
545                 550                 555                 


<210> 386
<211> 558
<212> PRT
<213> Cichorium intybus

<220> 
<223> germacrene A synthase short form Acc. No. AAM21659

<400> 386
Met Ala Ala Val Glu Ala Asn Gly Thr Phe Gln Ala Asn Thr Lys Thr
 1               5                  10                  15      
Thr Glu Pro Val Arg Pro Leu Ala Asn Phe Pro Pro Ser Val Trp Gly
            20                  25                  30          
Asp Arg Phe Leu Ser Phe Ser Leu Asp Thr Thr Glu Leu Glu Gly Tyr
        35                  40                  45              
Ala Lys Ala Met Glu Glu Pro Lys Glu Glu Val Arg Lys Leu Ile Val
    50                  55                  60                  
Asp Pro Thr Met Asp Ser Asn Lys Lys Leu Ser Leu Ile Tyr Ser Val
65                  70                  75                  80  
His Arg Leu Gly Leu Thr Tyr Leu Phe Leu Gln Glu Ile Glu Ala Gln
                85                  90                  95      
Leu Asp Lys Leu Phe Lys Glu Phe Asn Leu Gln Asp Tyr Asp Glu Phe
            100                 105                 110         
Asp Leu Tyr Thr Thr Ser Ile Asn Phe Gln Val Phe Arg His Leu Gly
        115                 120                 125             
His Lys Leu Pro Cys Asp Val Phe Asn Lys Phe Lys Asp Ser Ser Ser
    130                 135                 140                 
Gly Thr Phe Lys Glu Ser Ile Thr Asn Asp Val Lys Gly Met Leu Gly
145                 150                 155                 160 
Leu Tyr Glu Ser Ala Gln Leu Arg Leu Arg Gly Glu Pro Ile Leu Asp
                165                 170                 175     
Glu Ala Ser Ala Phe Thr Glu Thr Gln Leu Lys Ser Val Val Asn Thr
            180                 185                 190         
Leu Glu Gly Asn Leu Ala Lys Gln Val Met Gln Ser Leu Arg Arg Pro
        195                 200                 205             
Phe His Gln Gly Met Pro Met Val Glu Ala Arg Met Tyr Phe Ser Asn
    210                 215                 220                 
Tyr Asp Glu Glu Cys Ser Thr His Glu Ser Leu Pro Lys Leu Ala Lys
225                 230                 235                 240 
Leu His Phe Asn Tyr Leu Gln Leu Gln Gln Lys Glu Glu Leu Arg Ile
                245                 250                 255     
Val Ser Lys Trp Trp Lys Asp Met Arg Phe Gln Glu Thr Thr Pro Tyr
            260                 265                 270         
Ile Arg Asp Arg Val Pro Glu Ile Tyr Leu Trp Ile Leu Gly Leu Tyr
        275                 280                 285             
Phe Glu Pro Arg Tyr Ser Leu Ala Arg Ile Ile Ala Thr Lys Ile Thr
    290                 295                 300                 
Leu Phe Leu Val Val Leu Asp Asp Thr Tyr Asp Ala Tyr Ala Thr Ile
305                 310                 315                 320 
Glu Glu Ile Arg Leu Leu Thr Asp Ala Ile Asn Arg Trp Asp Ile Ser
                325                 330                 335     
Ala Met Glu Gln Ile Pro Glu Tyr Ile Arg Pro Phe Tyr Lys Ile Leu
            340                 345                 350         
Leu Asp Glu Tyr Ala Glu Leu Glu Lys Gln Leu Ala Lys Glu Gly Arg
        355                 360                 365             
Ala Lys Ser Val Ile Ala Ser Lys Glu Ala Phe Gln Asp Ile Ala Arg
    370                 375                 380                 
Gly Tyr Leu Glu Glu Ala Glu Trp Thr Asn Ser Gly Tyr Val Ala Ser
385                 390                 395                 400 
Phe Pro Glu Tyr Met Lys Asn Gly Leu Ile Thr Ser Ala Tyr Asn Val
                405                 410                 415     
Ile Ser Lys Ser Ala Leu Val Gly Met Gly Glu Met Val Gly Glu Asp
            420                 425                 430         
Ala Leu Ala Trp Tyr Glu Ser His Pro Lys Thr Leu Gln Ala Ser Glu
        435                 440                 445             
Leu Ile Ser Arg Leu Gln Asp Asp Val Met Thr Tyr Gln Phe Glu Arg
    450                 455                 460                 
Glu Arg Gly Gln Ser Ala Thr Gly Val Asp Ser Tyr Ile Lys Thr Tyr
465                 470                 475                 480 
Gly Val Thr Glu Lys Glu Ala Ile Asp Glu Leu Asn Lys Met Ile Glu
                485                 490                 495     
Asn Ala Trp Lys Asp Ile Asn Glu Gly Cys Leu Lys Pro Arg Glu Val
            500                 505                 510         
Ser Met Asp Leu Leu Ala Pro Ile Leu Asn Leu Ala Arg Met Ile Asp
        515                 520                 525             
Val Val Tyr Arg Tyr Asp Asp Gly Phe Thr Phe Pro Gly Lys Thr Met
    530                 535                 540                 
Lys Glu Tyr Ile Thr Leu Leu Phe Val Gly Ser Ser Pro Met
545                 550                 555             


<210> 387
<211> 583
<212> PRT
<213> Cichorium intybus

<220> 
<223> germacrene A synthase long form Acc. No. AAM21658

<400> 387
Met Ala Leu Val Arg Asn Asn Ser Ser Asn Gly Arg Glu Pro Val Leu
 1               5                  10                  15      
Ser Pro Arg Ser Leu Thr Ser Pro Arg Gly Leu Thr Ser Pro Arg Pro
            20                  25                  30          
Leu Ser Val Gln Pro Thr Pro Glu Pro Val Arg Pro Leu Ala Asn Phe
        35                  40                  45              
Pro Pro Ser Ile Trp Ala Asp Arg Phe Ile Ser Phe Ser Leu Asp Asn
    50                  55                  60                  
Ser Gln Leu Glu Ala Tyr Ala Asn Ala Leu Glu Glu Pro Lys Glu Ala
65                  70                  75                  80  
Val Lys Ser Leu Ile Thr Asp Thr Thr Ile Asp Ala Asn Thr Lys Leu
                85                  90                  95      
Lys Leu Ile Tyr Ser Val His Arg Leu Gly Leu Ser Tyr Leu Tyr Pro
            100                 105                 110         
Asp Glu Ile Asp Ala Glu Leu Asn Lys Leu Phe Glu Lys Ile Asp Leu
        115                 120                 125             
Gln Tyr Tyr Glu Gln Val Asp Leu Tyr Thr Ile Ala Val Gln Phe Gln
    130                 135                 140                 
Val Phe Arg His His Gly Tyr Lys Ile Ser Ser Asp Val Phe Lys Lys
145                 150                 155                 160 
Phe Lys Asp Ser Thr Thr Gly Thr Phe Thr Asp Asp Val Thr Lys Asp
                165                 170                 175     
Val Lys Gly Met Leu Ser Leu Tyr Glu Ser Ala His Leu Arg Leu His
            180                 185                 190         
Gly Glu Asp Ile Leu Asp Glu Ala Leu Ala Phe Thr Glu Ala His Leu
        195                 200                 205             
Lys Lys Ile Leu Thr Thr Leu Glu Gly Asp Leu Ala Arg Gln Val Asn
    210                 215                 220                 
Gln Val Leu Lys Arg Pro Phe His Thr Gly Met Pro Met Val Glu Ala
225                 230                 235                 240 
Arg Leu Tyr Phe Ile Thr His Glu Glu Asp Phe Ser Ser His Glu Ser
                245                 250                 255     
Val Val Lys Leu Ala Lys Val His Phe Asn Tyr Leu Gln Leu Gln Gln
            260                 265                 270         
Lys Glu Glu Leu Arg Leu Val Ser Gln Trp Trp Lys Asp Met Gln Phe
        275                 280                 285             
Gln Gln Ser Val Pro Tyr Ile Arg Asp Arg Val Pro Glu Ile Tyr Leu
    290                 295                 300                 
Trp Ile Leu Gly Leu Tyr Phe Glu Pro Tyr Tyr Ser Arg Ala Arg Ile
305                 310                 315                 320 
Ile Ala Thr Lys Ile Thr Leu Phe Leu Val Val Leu Asp Asp Thr Tyr
                325                 330                 335     
Asp Ala Tyr Ala Thr Ile Asp Glu Ile Arg Ser Ile Thr Asp Ala Ile
            340                 345                 350         
Asn Arg Trp Glu Ile Ser Ala Ile Asp Gln Leu Pro Glu Tyr Ile Lys
        355                 360                 365             
Pro Phe Tyr Arg Ile Leu Leu Asn Glu Tyr Asp Asp Leu Glu Lys Glu
    370                 375                 380                 
Tyr Ser Lys Asp Gly Arg Ala Phe Ser Val His Ala Ser Lys Gln Ala
385                 390                 395                 400 
Phe Gln Glu Ile Ala Arg Gly Tyr Leu Glu Glu Ala Glu Trp Leu His
                405                 410                 415     
Asn Gly Tyr Val Ala Thr Phe Pro Glu Tyr Met Lys Asn Gly Leu Ile
            420                 425                 430         
Thr Ser Ala Tyr Asn Val Ile Ser Lys Ser Ala Leu Val Gly Met Gly
        435                 440                 445             
Ala Ile Ala Asp Glu Glu Ala Leu Ala Trp Tyr Glu Thr His Pro Lys
    450                 455                 460                 
Ile Leu Lys Ala Ser Glu Leu Ile Ser Arg Leu Gln Asp Asp Val Met
465                 470                 475                 480 
Thr Phe Gln Phe Glu Arg Lys Arg Gly Gln Ser Ala Thr Gly Val Asp
                485                 490                 495     
Ala Tyr Ile Lys Glu Tyr Asn Val Ser Glu Glu Val Ala Ile Lys Glu
            500                 505                 510         
Leu Met Lys Met Ile Glu Asn Ala Trp Lys Asp Ile Asn Glu Gly Cys
        515                 520                 525             
Leu Lys Pro Thr Glu Val Ser Val Ala Leu Leu Thr Pro Ile Leu Asn
    530                 535                 540                 
Leu Ala Arg Met Ile Asp Val Val Tyr Lys Phe Asp Asp Gly Phe Thr
545                 550                 555                 560 
Phe Pro Gly Lys Thr Leu Lys Asp Tyr Ile Thr Leu Leu Phe Val Ser
                565                 570                 575     
Pro Pro Pro Ser Leu Glu Asn
            580             


<210> 388
<211> 603
<212> PRT
<213> Cinnamomum tenuipile

<220> 
<223> geraniol synthase Acc. No. CAD29734

<400> 388
Met Ala Leu Gln Met Ile Ala Pro Phe Leu Ser Ser Phe Leu Pro Asn
 1               5                  10                  15      
Pro Arg His Ser Leu Ala Ala His Gly Leu Thr His Gln Lys Cys Val
            20                  25                  30          
Ser Lys His Ile Ser Cys Ser Thr Thr Thr Pro Thr Tyr Ser Thr Thr
        35                  40                  45              
Val Pro Arg Arg Ser Gly Asn Tyr Lys Pro Ser Ile Trp Asp Tyr Asp
    50                  55                  60                  
Phe Val Gln Ser Leu Gly Ser Gly Tyr Lys Val Glu Ala His Gly Thr
65                  70                  75                  80  
Arg Val Lys Lys Leu Lys Glu Val Val Lys His Leu Leu Lys Glu Thr
                85                  90                  95      
Asp Ser Ser Leu Ala Gln Ile Glu Leu Ile Asp Lys Leu Arg Arg Leu
            100                 105                 110         
Gly Leu Arg Trp Leu Phe Lys Asn Glu Ile Lys Gln Val Leu Tyr Thr
        115                 120                 125             
Ile Ser Ser Asp Asn Thr Ser Ile Glu Met Arg Lys Asp Leu His Ala
    130                 135                 140                 
Val Ser Thr Arg Phe Arg Leu Leu Arg Gln His Gly Tyr Lys Val Ser
145                 150                 155                 160 
Thr Asp Val Phe Asn Asp Phe Lys Asp Glu Lys Gly Cys Phe Lys Pro
                165                 170                 175     
Ser Leu Ser Met Asp Ile Lys Gly Met Leu Ser Leu Tyr Glu Ala Ser
            180                 185                 190         
His Leu Ala Phe Gln Gly Glu Thr Val Leu Asp Glu Ala Arg Ala Phe
        195                 200                 205             
Val Ser Thr His Leu Met Asp Ile Lys Glu Asn Ile Asp Pro Ile Leu
    210                 215                 220                 
His Lys Lys Val Glu His Ala Leu Asp Met Pro Leu His Trp Arg Leu
225                 230                 235                 240 
Glu Lys Leu Glu Ala Arg Trp Tyr Met Asp Ile Tyr Met Arg Glu Glu
                245                 250                 255     
Gly Met Asn Ser Ser Leu Leu Glu Leu Ala Met Leu His Phe Asn Ile
            260                 265                 270         
Val Gln Thr Thr Phe Gln Thr Asn Leu Lys Ser Leu Ser Arg Trp Trp
        275                 280                 285             
Lys Asp Leu Gly Leu Gly Glu Gln Leu Ser Phe Thr Arg Asp Arg Leu
    290                 295                 300                 
Val Glu Cys Phe Phe Trp Ala Ala Ala Met Thr Pro Glu Pro Gln Phe
305                 310                 315                 320 
Gly Arg Cys Gln Glu Val Val Ala Lys Val Ala Gln Leu Ile Ile Ile
                325                 330                 335     
Ile Asp Asp Ile Tyr Asp Val Tyr Gly Thr Val Asp Glu Leu Glu Leu
            340                 345                 350         
Phe Thr Asn Ala Ile Asp Arg Trp Asp Leu Glu Ala Met Glu Gln Leu
        355                 360                 365             
Pro Glu Tyr Met Lys Thr Cys Phe Leu Ala Leu Tyr Asn Ser Ile Asn
    370                 375                 380                 
Glu Ile Gly Tyr Asp Ile Leu Lys Glu Glu Gly Arg Asn Val Ile Pro
385                 390                 395                 400 
Tyr Leu Arg Asn Thr Trp Thr Glu Leu Cys Lys Ala Phe Leu Val Glu
                405                 410                 415     
Ala Lys Trp Tyr Ser Ser Gly Tyr Thr Pro Thr Leu Glu Glu Tyr Leu
            420                 425                 430         
Gln Thr Ser Trp Ile Ser Ile Gly Ser Leu Pro Met Gln Thr Tyr Val
        435                 440                 445             
Phe Ala Leu Leu Gly Lys Asn Leu Ala Pro Glu Ser Ser Asp Phe Ala
    450                 455                 460                 
Glu Lys Ile Ser Asp Ile Leu Arg Leu Gly Gly Met Met Ile Arg Leu
465                 470                 475                 480 
Pro Asp Asp Leu Gly Thr Ser Thr Asp Glu Leu Lys Arg Gly Asp Val
                485                 490                 495     
Pro Lys Ser Ile Gln Cys Tyr Met His Glu Ala Gly Val Thr Glu Asp
            500                 505                 510         
Val Ala Arg Asp His Ile Met Gly Leu Phe Gln Glu Thr Trp Lys Lys
        515                 520                 525             
Leu Asn Glu Tyr Leu Val Glu Ser Ser Leu Pro His Ala Phe Ile Asp
    530                 535                 540                 
His Ala Met Asn Leu Gly Arg Val Ser Tyr Cys Thr Tyr Lys His Gly
545                 550                 555                 560 
Asp Gly Phe Ser Asp Gly Phe Gly Asp Pro Gly Ser Gln Glu Lys Lys
                565                 570                 575     
Met Phe Met Ser Leu Phe Ala Glu Pro Leu Gln Val Asp Glu Ala Lys
            580                 585                 590         
Gly Ile Ser Phe Tyr Val Asp Gly Gly Ser Ala
        595                 600             


<210> 389
<211> 572
<212> PRT
<213> Cistus creticus

<220> 
<223> germacrene B synthase Acc. No. ACF94469

<400> 389
Met Phe Thr Gln Thr Ser Leu Ser Ser Ser Ala Pro Ala Leu Ser Thr
 1               5                  10                  15      
Gln Asn Ala Lys Pro Glu Ile Val Arg Arg Ser Ala Gly Phe His Pro
            20                  25                  30          
Ser Ile Trp Gly Asp Gln Phe Leu Ser Tyr Ala Ser Asn Pro Val Val
        35                  40                  45              
Glu Asn Glu Glu Glu Lys Arg Glu His Asp Leu Leu Lys Gly Lys Leu
    50                  55                  60                  
Lys Glu Lys Leu Met Thr Ala Ala Glu Asn Lys Ser Leu Ile Glu Asp
65                  70                  75                  80  
Lys Glu Thr Leu Asp Leu Ile Asp Leu Ile Gln Arg Leu Cys Val Ser
                85                  90                  95      
Tyr His Phe Glu Lys Glu Ile Ser Arg Ile Leu Glu Gln Ile Met Gln
            100                 105                 110         
Leu Val Thr His Asn Asp His Asp His Asn His Asp Asp Gly Asp Leu
        115                 120                 125             
Tyr Thr Thr Ser Leu Arg Phe Arg Leu Leu Arg Gln Asn Gly Tyr Arg
    130                 135                 140                 
Ile Pro Cys Gly Val Phe Asn Lys Phe Lys Asp Ser Glu Gly Asn Phe
145                 150                 155                 160 
Lys Glu Ser Leu Ile Cys Asp Val Lys Gly Met Leu Ser Leu Tyr Glu
                165                 170                 175     
Ala Ala His Leu Arg Ile Gln Gly Glu Asp Ile Leu Asp Glu Ala Leu
            180                 185                 190         
Ser Phe Thr Ser Thr Gln Leu Gly Ala Ala Lys Thr Thr Ile Thr Thr
        195                 200                 205             
Thr Asn Pro Ser Leu Ala Ala Gln Val Ala His Ala Leu Lys Gln Pro
    210                 215                 220                 
Ile Arg Lys Gly Leu Pro Arg Leu Gln Ala Arg Arg Phe Met Pro Val
225                 230                 235                 240 
Tyr Glu Ala Asp Pro Cys His Asp Lys Thr Leu Leu Thr Phe Ala Lys
                245                 250                 255     
Leu Asp Phe Asn Met Leu Gln Arg Leu His Gln Lys Glu Val Gly Glu
            260                 265                 270         
Ile Thr Lys Trp Trp Lys Asp Ile Asp Phe Ser Asn Lys Met Pro Phe
        275                 280                 285             
Ala Arg Asp Arg Val Val Glu Cys Tyr Phe Trp Thr Leu Gly Val Tyr
    290                 295                 300                 
Phe Glu Pro Lys Tyr Thr Leu Gly Arg Lys Ile Phe Asn Lys Val Ile
305                 310                 315                 320 
Ala Met Thr Ser Val Leu Asp Asp Ile Tyr Asp Val Tyr Gly Thr Leu
                325                 330                 335     
Asp Glu Leu Glu Ile Phe Thr Glu Ala Ile Leu Arg Trp Asp Ile Asn
            340                 345                 350         
Thr Ile Ser Gln Leu Pro Ser Tyr Met Gln Ile Tyr Tyr Gln Ala Phe
        355                 360                 365             
Ile Asp Val Tyr Ser Glu Met Glu Ala Gln Met Glu Val Glu Asp Lys
    370                 375                 380                 
Leu Tyr Cys Val Pro Tyr Ala Lys Glu Val Met Lys Lys Leu Val Arg
385                 390                 395                 400 
Ala Tyr His Gln Glu Ser Lys Trp Phe His Ala Asn Tyr Val Pro Pro
                405                 410                 415     
Met Glu Glu Tyr Met Ser Val Ala Leu Val Ser Ser Gly Tyr Glu Val
            420                 425                 430         
Leu Ala Ala Thr Ser Phe Val Gly Met Gly Asp Val Val Thr Lys Asp
        435                 440                 445             
Ser Phe Glu Trp Leu Phe Asn Tyr Pro Lys Ile Ile Thr Ala Ser Leu
    450                 455                 460                 
Ile Met Gly Arg Leu Met Asn Asp Ile Val Gly His Lys Phe Glu Gln
465                 470                 475                 480 
Lys Arg Gly His Val Ala Ser Ala Val Glu Cys Tyr Val Lys Gln Tyr
                485                 490                 495     
Gly Gly Thr Glu Glu Glu Ala Val Glu Glu Phe Arg Lys Gln Ile Thr
            500                 505                 510         
Asn Ala Trp Lys Asp Ile Asn Glu Glu Cys Leu Cys Pro Thr Ala Val
        515                 520                 525             
Pro Met Pro Leu Leu Thr Arg Val Leu Asn Leu Ala Arg Val Leu Glu
    530                 535                 540                 
Val Ile Tyr Asn Ile Asp Asp Cys Tyr Thr Asn Ser Lys Leu Ile Val
545                 550                 555                 560 
Lys Asp Ile Ala Ser Leu Leu Ile Asn Pro Val Pro
                565                 570         


<210> 390
<211> 560
<212> PRT
<213> Citrus junos

<220> 
<223> (E)-beta-farnesene synthase Acc. No. AAK54279

<400> 390
Met Lys Asp Met Ser Ile Pro Leu Leu Ala Ala Val Ser Ser Ser Thr
 1               5                  10                  15      
Glu Glu Thr Val Arg Pro Ile Ala Asp Phe His Pro Thr Leu Trp Gly
            20                  25                  30          
Asn His Phe Leu Lys Ser Ala Ala Asp Val Glu Thr Ile Asp Ala Ala
        35                  40                  45              
Thr Gln Glu Gln His Ala Ala Leu Lys Gln Glu Val Arg Arg Met Ile
    50                  55                  60                  
Thr Thr Thr Ala Asn Lys Leu Ala Gln Lys Leu His Met Ile Asp Ala
65                  70                  75                  80  
Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys Glu Ile Glu Asp
                85                  90                  95      
Glu Leu Gly Lys Val Ser His Asp Leu Asp Ser Asp Asp Leu Tyr Val
            100                 105                 110         
Val Ser Leu Arg Phe Arg Leu Phe Arg Gln Gln Gly Val Lys Ile Ser
        115                 120                 125             
Cys Asp Val Phe Asp Lys Phe Lys Asp Asp Glu Gly Lys Phe Lys Glu
    130                 135                 140                 
Ser Leu Ile Asn Asp Ile Arg Gly Met Leu Ser Leu Tyr Glu Ala Ala
145                 150                 155                 160 
Tyr Leu Ala Ile Arg Gly Glu Asp Ile Leu Asp Glu Ala Ile Val Phe
                165                 170                 175     
Thr Thr Thr His Leu Lys Ser Val Ile Ser Ile Ser Asp His Ser His
            180                 185                 190         
Ala Asn Ser Asn Leu Ala Glu Gln Ile Arg His Ser Leu Gln Ile Pro
        195                 200                 205             
Leu Arg Lys Ala Ala Ala Arg Leu Glu Ala Arg Tyr Phe Leu Asp Ile
    210                 215                 220                 
Tyr Ser Arg Asp Asp Leu His Asp Glu Thr Leu Leu Lys Phe Ala Lys
225                 230                 235                 240 
Leu Asp Phe Asn Ile Leu Gln Ala Ala His Gln Lys Glu Ala Ser Ile
                245                 250                 255     
Met Thr Arg Trp Trp Asn Asp Leu Gly Phe Pro Lys Lys Val Pro Tyr
            260                 265                 270         
Ala Arg Asp Arg Ile Ile Glu Thr Tyr Ile Trp Met Leu Leu Gly Val
        275                 280                 285             
Ser Tyr Glu Pro Asn Leu Ala Phe Gly Arg Ile Phe Ala Ser Lys Val
    290                 295                 300                 
Val Cys Met Ile Thr Thr Ile Asp Asp Thr Phe Asp Ala Tyr Gly Thr
305                 310                 315                 320 
Phe Glu Glu Leu Thr Leu Phe Thr Glu Ala Val Thr Arg Trp Asp Ile
                325                 330                 335     
Gly Leu Ile Asp Thr Leu Pro Glu Tyr Met Lys Phe Ile Val Lys Ala
            340                 345                 350         
Leu Leu Asp Ile Tyr Arg Glu Ala Glu Glu Glu Leu Ala Lys Glu Gly
        355                 360                 365             
Arg Ser Tyr Gly Ile Pro Tyr Ala Lys Gln Met Met Gln Glu Leu Ile
    370                 375                 380                 
Ile Leu Tyr Phe Thr Glu Ala Lys Trp Leu Tyr Lys Gly Tyr Val Pro
385                 390                 395                 400 
Thr Phe Asp Glu Tyr Lys Ser Val Ala Leu Arg Ser Ile Gly Leu Arg
                405                 410                 415     
Thr Leu Ala Val Ala Ser Phe Val Asp Leu Gly Asp Phe Ile Ala Thr
            420                 425                 430         
Lys Asp Asn Phe Glu Cys Ile Leu Lys Asn Ala Lys Ser Leu Lys Ala
        435                 440                 445             
Thr Glu Thr Ile Gly Arg Leu Met Asp Asp Ile Ala Gly Tyr Lys Phe
    450                 455                 460                 
Glu Gln Lys Arg Gly His Asn Pro Ser Ala Val Glu Cys Tyr Lys Asn
465                 470                 475                 480 
Gln His Gly Val Ser Glu Glu Glu Ala Val Lys Glu Leu Leu Leu Glu
                485                 490                 495     
Val Ala Asn Ser Trp Lys Asp Ile Asn Glu Glu Leu Leu Asn Pro Thr
            500                 505                 510         
Thr Val Pro Leu Pro Met Leu Gln Arg Leu Leu Tyr Phe Ala Arg Ser
        515                 520                 525             
Gly His Phe Ile Tyr Asp Asp Gly His Asp Arg Tyr Thr His Ser Leu
    530                 535                 540                 
Met Met Lys Arg Gln Val Ala Leu Leu Leu Thr Glu Pro Leu Ala Ile
545                 550                 555                 560 


<210> 391
<211> 555
<212> PRT
<213> Citrus junos

<220> 
<223> terpene synthase Acc. No. AAG01339

<400> 391
Met Ser Ala Gln Val Leu Ala Thr Val Ser Ser Ser Thr Glu Lys Thr
 1               5                  10                  15      
Val Arg Pro Ile Ala Gly Phe His Pro Asn Leu Trp Gly Asp Tyr Phe
            20                  25                  30          
Leu Thr Leu Ala Ser Asp Cys Lys Thr Asp Asp Thr Thr His Gln Glu
        35                  40                  45              
Glu Tyr Glu Ala Leu Lys Gln Glu Val Arg Ser Met Ile Thr Ala Thr
    50                  55                  60                  
Ala Asp Thr Pro Ala Gln Lys Leu Gln Leu Val Asp Ala Val Gln Arg
65                  70                  75                  80  
Leu Gly Val Ala Tyr His Phe Glu Gln Glu Ile Glu Asp Ala Met Glu
                85                  90                  95      
Lys Ile Tyr His Asp Asp Phe Asp Asn Asn Asp Asp Val Asp Leu Tyr
            100                 105                 110         
Thr Val Ser Leu Arg Phe Arg Leu Leu Arg Gln Gln Gly Phe Lys Val
        115                 120                 125             
Pro Cys Asp Val Phe Ala Lys Phe Lys Asp Asp Glu Gly Lys Phe Lys
    130                 135                 140                 
Ala Ser Leu Val Arg Asp Val His Gly Ile Leu Ser Leu Tyr Glu Ala
145                 150                 155                 160 
Gly His Leu Ala Ile Arg Gly Glu Gly Ile Leu Asp Glu Ala Ile Ala
                165                 170                 175     
Phe Thr Arg Thr His Leu Gln Ser Met Val Ser Gln Asp Val Cys Pro
            180                 185                 190         
Asn Asn Leu Ala Glu Gln Ile Asn His Thr Leu Asp Cys Pro Leu Arg
        195                 200                 205             
Arg Ala Leu Pro Arg Val Glu Thr Arg Phe Phe Leu Ser Val Tyr Pro
    210                 215                 220                 
Arg Asp Asp Lys His Asp Lys Thr Leu Leu Lys Phe Ser Lys Leu Asp
225                 230                 235                 240 
Phe Asn Leu Val Gln Arg Ile His Gln Lys Glu Leu Ser Ala Ile Thr
                245                 250                 255     
Arg Trp Trp Lys Asp Leu Asp Phe Thr Thr Lys Leu Pro Tyr Ala Arg
            260                 265                 270         
Asp Arg Ile Val Glu Leu Tyr Phe Trp Ile Val Gly Thr Tyr Phe Glu
        275                 280                 285             
Pro Lys Tyr Thr Leu Ala Arg Lys Ile Met Thr Lys Thr Ile Tyr Thr
    290                 295                 300                 
Ala Ser Ile Ile Asp Asp Thr Phe Asp Ala Tyr Gly Phe Phe Glu Glu
305                 310                 315                 320 
Leu Lys Leu Phe Ala Glu Ala Val Gln Arg Trp Asp Ile Gly Ala Met
                325                 330                 335     
Asp Ile Leu Pro Glu Tyr Met Lys Val Leu Tyr Lys Ala Leu Leu Asp
            340                 345                 350         
Thr Phe Asn Glu Ile Glu Gln Asp Leu Ala Lys Glu Gly Arg Ser Ser
        355                 360                 365             
Cys Leu Pro Tyr Gly Lys Glu Lys Met Gln Glu Leu Val Gln Met Tyr
    370                 375                 380                 
Phe Val Gln Ala Lys Trp Phe Ser Glu Gly Tyr Val Pro Thr Trp Asp
385                 390                 395                 400 
Glu Tyr Tyr Pro Val Gly Leu Val Ser Cys Gly Tyr Phe Met Leu Ala
                405                 410                 415     
Thr Asn Ser Phe Leu Gly Met Cys Asp Val Ala Asn Lys Glu Ser Phe
            420                 425                 430         
Glu Trp Ile Ser Arg Thr Leu Arg Phe Gln Gln Arg His Gln Phe Ile
        435                 440                 445             
Cys Arg Leu Arg Asn Asp Ile Val Ser His Gln Phe Glu Gln Lys Arg
    450                 455                 460                 
Gly His Ile Ala Ser Gly Val Glu Cys Tyr Ile Lys Gln Tyr Gly Val
465                 470                 475                 480 
Ser Ala Glu Glu Val Val Thr Val Phe Thr Glu Glu Val Glu Asn Ala
                485                 490                 495     
Trp Lys Asp Met Asn Glu Glu Phe Leu Lys Pro Thr Ala Phe Pro Val
            500                 505                 510         
Ala Leu Ile Glu Arg Pro Phe Asn Ile Ala Arg Val Ile Glu Phe Leu
        515                 520                 525             
Asn Lys Lys Gly Asp Trp Tyr Thr His Ser His Ala Ile Lys Asp Gln
    530                 535                 540                 
Ile Ala Ala Val Leu Arg Asp Pro Val Thr Ile
545                 550                 555 


<210> 392
<211> 600
<212> PRT
<213> Citrus limon

<220> 
<223> gamma-terpinene synthase Acc. No. AAM53943

<400> 392
Met Ala Leu Asn Leu Leu Ser Ser Leu Pro Ala Ala Cys Asn Phe Thr
 1               5                  10                  15      
Arg Leu Ser Leu Pro Leu Ser Ser Lys Val Asn Gly Phe Val Pro Pro
            20                  25                  30          
Ile Thr Gln Val Gln Tyr Pro Met Ala Ala Ser Thr Ser Ser Ile Lys
        35                  40                  45              
Pro Val Asp Gln Thr Ile Ile Arg Arg Ser Ala Asp Tyr Gly Pro Thr
    50                  55                  60                  
Ile Trp Ser Phe Asp Tyr Ile Gln Ser Leu Asp Ser Lys Tyr Lys Gly
65                  70                  75                  80  
Glu Ser Tyr Ala Arg Gln Leu Glu Lys Leu Lys Glu Gln Val Ser Ala
                85                  90                  95      
Met Leu Gln Gln Asp Asn Lys Val Val Asp Leu Asp Pro Leu His Gln
            100                 105                 110         
Leu Glu Leu Ile Asp Asn Leu His Arg Leu Gly Val Ser Tyr His Phe
        115                 120                 125             
Glu Asp Glu Ile Lys Arg Thr Leu Asp Arg Ile His Asn Lys Asn Thr
    130                 135                 140                 
Asn Lys Ser Leu Tyr Ala Arg Ala Leu Lys Phe Arg Ile Leu Arg Gln
145                 150                 155                 160 
Tyr Gly Tyr Lys Thr Pro Val Lys Glu Thr Phe Ser Arg Phe Met Asp
                165                 170                 175     
Glu Lys Gly Ser Phe Lys Leu Ser Ser His Ser Asp Glu Cys Lys Gly
            180                 185                 190         
Met Leu Ala Leu Tyr Glu Ala Ala Tyr Leu Leu Val Glu Glu Glu Ser
        195                 200                 205             
Ser Ile Phe Arg Asp Ala Ile Arg Phe Thr Thr Ala Tyr Leu Lys Glu
    210                 215                 220                 
Trp Val Ala Lys His Asp Ile Asp Lys Asn Asp Asn Glu Tyr Leu Cys
225                 230                 235                 240 
Thr Leu Val Lys His Ala Leu Glu Leu Pro Leu His Trp Arg Met Arg
                245                 250                 255     
Arg Leu Glu Ala Arg Trp Phe Ile Asp Val Tyr Glu Ser Gly Pro Asp
            260                 265                 270         
Met Asn Pro Ile Leu Leu Glu Leu Ala Lys Val Asp Tyr Asn Ile Val
        275                 280                 285             
Gln Ala Val His Gln Glu Asp Leu Lys Tyr Val Ser Arg Trp Trp Lys
    290                 295                 300                 
Lys Thr Gly Leu Gly Glu Lys Leu Asn Phe Ala Arg Asp Arg Val Val
305                 310                 315                 320 
Glu Asn Phe Phe Trp Thr Val Gly Asp Ile Phe Glu Pro Gln Phe Gly
                325                 330                 335     
Tyr Cys Arg Arg Met Ser Ala Met Val Asn Cys Leu Leu Thr Ser Ile
            340                 345                 350         
Asp Asp Val Tyr Asp Val Tyr Gly Thr Leu Asp Glu Leu Glu Leu Phe
        355                 360                 365             
Thr Asp Ala Val Glu Arg Trp Asp Ala Thr Thr Thr Glu Gln Leu Pro
    370                 375                 380                 
Tyr Tyr Met Lys Leu Cys Phe His Ala Leu Tyr Asn Ser Val Asn Glu
385                 390                 395                 400 
Met Gly Phe Ile Ala Leu Arg Asp Gln Glu Val Gly Met Ile Ile Pro
                405                 410                 415     
Tyr Leu Lys Lys Ala Trp Ala Asp Gln Cys Lys Ser Tyr Leu Val Glu
            420                 425                 430         
Ala Lys Trp Tyr Asn Ser Gly Tyr Ile Pro Thr Leu Gln Glu Tyr Met
        435                 440                 445             
Glu Asn Ala Trp Ile Ser Val Thr Ala Pro Val Met Leu Leu His Ala
    450                 455                 460                 
Tyr Ala Phe Thr Ala Asn Pro Ile Thr Lys Glu Ala Leu Glu Phe Leu
465                 470                 475                 480 
Gln Asp Ser Pro Asp Ile Ile Arg Ile Ser Ser Met Ile Val Arg Leu
                485                 490                 495     
Glu Asp Asp Leu Gly Thr Ser Ser Asp Glu Leu Lys Arg Gly Asp Val
            500                 505                 510         
Pro Lys Ser Ile Gln Cys Tyr Met His Glu Thr Gly Val Ser Glu Asp
        515                 520                 525             
Glu Ala Arg Glu His Ile Arg Asp Leu Ile Ala Glu Thr Trp Met Lys
    530                 535                 540                 
Met Asn Ser Ala Arg Phe Gly Asn Pro Pro Tyr Leu Pro Asp Val Phe
545                 550                 555                 560 
Ile Gly Ile Ala Met Asn Leu Val Arg Met Ser Gln Cys Met Tyr Leu
                565                 570                 575     
Tyr Gly Asp Gly His Gly Val Gln Glu Asn Thr Lys Asp Arg Val Leu
            580                 585                 590         
Ser Leu Phe Ile Asp Pro Ile Pro
        595                 600 


<210> 393
<211> 606
<212> PRT
<213> Citrus limon

<220> 
<223> (+)-limonene synthase 1 synthase Acc. No. AAM53944

<400> 393
Met Ser Ser Cys Ile Asn Pro Ser Thr Leu Val Thr Ser Val Asn Ala
 1               5                  10                  15      
Phe Lys Cys Leu Pro Leu Ala Thr Asn Lys Ala Ala Ile Arg Ile Met
            20                  25                  30          
Ala Lys Tyr Lys Pro Val Gln Cys Leu Ile Ser Ala Lys Tyr Asp Asn
        35                  40                  45              
Leu Thr Val Asp Arg Arg Ser Ala Asn Tyr Gln Pro Ser Ile Trp Asp
    50                  55                  60                  
His Asp Phe Leu Gln Ser Leu Asn Ser Asn Tyr Thr Asp Glu Ala Tyr
65                  70                  75                  80  
Lys Arg Arg Ala Glu Glu Leu Arg Gly Lys Val Lys Ile Ala Ile Lys
                85                  90                  95      
Asp Val Ile Glu Pro Leu Asp Gln Leu Glu Leu Ile Asp Asn Leu Gln
            100                 105                 110         
Arg Leu Gly Leu Ala His Arg Phe Glu Thr Glu Ile Arg Asn Ile Leu
        115                 120                 125             
Asn Asn Ile Tyr Asn Asn Asn Lys Asp Tyr Asn Trp Arg Lys Glu Asn
    130                 135                 140                 
Leu Tyr Ala Thr Ser Leu Glu Phe Arg Leu Leu Arg Gln His Gly Tyr
145                 150                 155                 160 
Pro Val Ser Gln Glu Val Phe Asn Gly Phe Lys Asp Asp Gln Gly Gly
                165                 170                 175     
Phe Ile Cys Asp Asp Phe Lys Gly Ile Leu Ser Leu His Glu Ala Ser
            180                 185                 190         
Tyr Tyr Ser Leu Glu Gly Glu Ser Ile Met Glu Glu Ala Trp Gln Phe
        195                 200                 205             
Thr Ser Lys His Leu Lys Glu Val Met Ile Ser Lys Asn Met Glu Glu
    210                 215                 220                 
Asp Val Phe Val Ala Glu Gln Ala Lys Arg Ala Leu Glu Leu Pro Leu
225                 230                 235                 240 
His Trp Lys Val Pro Met Leu Glu Ala Arg Trp Phe Ile His Ile Tyr
                245                 250                 255     
Glu Arg Arg Glu Asp Lys Asn His Leu Leu Leu Glu Leu Ala Lys Met
            260                 265                 270         
Glu Phe Asn Thr Leu Gln Ala Ile Tyr Gln Glu Glu Leu Lys Glu Ile
        275                 280                 285             
Ser Gly Trp Trp Lys Asp Thr Gly Leu Gly Glu Lys Leu Ser Phe Ala
    290                 295                 300                 
Arg Asn Arg Leu Val Ala Ser Phe Leu Trp Ser Met Gly Ile Ala Phe
305                 310                 315                 320 
Glu Pro Gln Phe Ala Tyr Cys Arg Arg Val Leu Thr Ile Ser Ile Ala
                325                 330                 335     
Leu Ile Thr Val Ile Asp Asp Ile Tyr Asp Val Tyr Gly Thr Leu Asp
            340                 345                 350         
Glu Leu Glu Ile Phe Thr Asp Ala Val Glu Arg Trp Asp Ile Asn Tyr
        355                 360                 365             
Ala Leu Lys His Leu Pro Gly Tyr Met Lys Met Cys Phe Leu Ala Leu
    370                 375                 380                 
Tyr Asn Phe Val Asn Glu Phe Ala Tyr Tyr Val Leu Lys Gln Gln Asp
385                 390                 395                 400 
Phe Asp Leu Leu Leu Ser Ile Lys Asn Ala Trp Leu Gly Leu Ile Gln
                405                 410                 415     
Ala Tyr Leu Val Glu Ala Lys Trp Tyr His Ser Lys Tyr Thr Pro Lys
            420                 425                 430         
Leu Glu Glu Tyr Leu Glu Asn Gly Leu Val Ser Ile Thr Gly Pro Leu
        435                 440                 445             
Ile Ile Thr Ile Ser Tyr Leu Ser Gly Thr Asn Pro Ile Ile Lys Lys
    450                 455                 460                 
Glu Leu Glu Phe Leu Glu Ser Asn Pro Asp Ile Val His Trp Ser Ser
465                 470                 475                 480 
Lys Ile Phe Arg Leu Gln Asp Asp Leu Gly Thr Ser Ser Asp Glu Ile
                485                 490                 495     
Gln Arg Gly Asp Val Pro Lys Ser Ile Gln Cys Tyr Met His Glu Thr
            500                 505                 510         
Gly Ala Ser Glu Glu Val Ala Arg Gln His Ile Lys Asp Met Met Arg
        515                 520                 525             
Gln Met Trp Lys Lys Val Asn Ala Tyr Thr Ala Asp Lys Asp Ser Pro
    530                 535                 540                 
Leu Thr Gly Thr Thr Thr Glu Phe Leu Leu Asn Leu Val Arg Met Ser
545                 550                 555                 560 
His Phe Met Tyr Leu His Gly Asp Gly His Gly Val Gln Asn Gln Glu
                565                 570                 575     
Thr Ile Asp Val Gly Phe Thr Leu Leu Phe Gln Pro Ile Pro Leu Glu
            580                 585                 590         
Asp Lys His Met Ala Phe Thr Ala Ser Pro Gly Thr Lys Gly
        595                 600                 605     


<210> 394
<211> 548
<212> PRT
<213> Citrus sinensis

<220> 
<223> terpene synthase 1 Acc. No. ACX70155

<400> 394
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 395
<211> 548
<212> PRT
<213> Citrus x paradisi

<220> 
<223> putative terpene synthase Acc. No. AAM00426

<400> 395
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Leu Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Pro His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asp Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 396
<211> 559
<212> PRT
<213> Crepidiastrum sonochifolium

<220> 
<223> germacrene A synthase Acc. No. ABB00361

<400> 396
Met Ala Ala Val Glu Ala Asn Gly Thr Leu Gln Ala Asn Thr Lys Thr
 1               5                  10                  15      
Thr Thr Glu Pro Val Arg Pro Leu Ala Asn Phe Pro Pro Ser Val Trp
            20                  25                  30          
Gly Asp Arg Phe Leu Ser Phe Ser Leu Asp Asn Lys Glu Leu Glu Gly
        35                  40                  45              
Tyr Ala Lys Ala Met Glu Glu Pro Lys Glu Glu Leu Arg Arg Leu Ile
    50                  55                  60                  
Val Asp Ser Thr Met Asp Ser Asn Lys Lys Leu Ser Leu Ile Tyr Ser
65                  70                  75                  80  
Val His Arg Leu Gly Leu Thr Tyr Leu Phe Leu Gln Glu Ile Glu Ala
                85                  90                  95      
Gln Leu Glu Lys Leu Phe Lys Glu Phe Asn Leu Gln Asp Tyr Asp Glu
            100                 105                 110         
Val Asp Leu Tyr Thr Thr Ser Ile Asn Phe Gln Val Phe Arg His Leu
        115                 120                 125             
Gly His Lys Leu Pro Cys Asp Val Phe Asn Lys Phe Lys Asp Ser Thr
    130                 135                 140                 
Ser Gly Lys Phe Lys Glu Tyr Ile Thr Asn Asp Val Lys Gly Met Leu
145                 150                 155                 160 
Gly Leu Tyr Glu Ser Ala Gln Leu Arg Val Arg Gly Glu Ser Ile Leu
                165                 170                 175     
Asp Glu Ala Ser Ala Phe Thr Glu Thr Lys Leu Lys Ser Val Val Asn
            180                 185                 190         
Thr Leu Glu Gly Lys Leu Glu Glu Gln Val Met Gln Ser Leu Arg Arg
        195                 200                 205             
Pro Phe His Gln Gly Met Pro Met Val Glu Ala Arg Leu Tyr Phe Ser
    210                 215                 220                 
Asn Tyr Thr Glu Glu Cys Ala Thr His Ala Ser Leu Leu Lys Leu Ala
225                 230                 235                 240 
Lys Leu His Phe Ser Tyr Leu Glu Leu Gln Gln Lys Glu Glu Leu Arg
                245                 250                 255     
Ile Val Ser Gln Trp Trp Lys Asp Met Glu Phe Gln Thr Ser Val Pro
            260                 265                 270         
Tyr Ile Arg Asp Arg Val Pro Glu Ile Tyr Leu Trp Ile Leu Gly Leu
        275                 280                 285             
Tyr Phe Glu Pro Arg Tyr Ser Leu Ala Arg Ile Ile Ala Thr Lys Ile
    290                 295                 300                 
Thr Leu Phe Leu Val Val Leu Asp Asp Thr Tyr Asp Ala Tyr Ala Thr
305                 310                 315                 320 
Ile Glu Glu Ile Arg Leu Leu Thr Asp Ala Ile Asn Arg Trp Asp Ile
                325                 330                 335     
Ser Ala Met Glu Gln Ile Pro Glu Tyr Ile Arg Pro Phe Tyr Lys Ile
            340                 345                 350         
Leu Leu Glu Glu Tyr Ala Glu Leu Glu Lys Gln Leu Ala Lys Glu Gly
        355                 360                 365             
Arg Glu Lys Ser Val Ile Ala Ser Lys Gln Ala Phe Gln Asp Ile Ala
    370                 375                 380                 
Asn Gly Tyr Leu Glu Glu Ala Glu Trp Thr Asn Ser Gly Tyr Val Ala
385                 390                 395                 400 
Thr Phe Pro Glu Tyr Met Lys Asn Gly Leu Ile Thr Ser Ala Tyr Asn
                405                 410                 415     
Val Ile Ser Lys Ser Ala Leu Val Gly Met Gly Glu Met Val Ser Glu
            420                 425                 430         
His Ala Leu Ala Trp Tyr Glu Ser His Pro Lys Thr Leu Gln Ala Ser
        435                 440                 445             
Glu Leu Ile Ser Arg Leu Gln Asp Asp Val Met Thr Tyr Gln Phe Glu
    450                 455                 460                 
Arg Glu Arg Gly Gln Ser Ala Thr Gly Val Asp Ser Tyr Ile Lys Thr
465                 470                 475                 480 
Tyr Gly Val Ser Glu Lys Glu Ala Ile Asp Glu Leu Asn Lys Met Ile
                485                 490                 495     
Glu Asn Ala Trp Lys Asp Ile Asn Glu Gly Cys Leu Lys Pro Arg Glu
            500                 505                 510         
Val Ser Met Asp Val Leu Ala Pro Ile Leu Asn Leu Ala Arg Met Ile
        515                 520                 525             
Asp Val Val Tyr Arg Tyr Asp Asp Gly Phe Thr Phe Pro Gly Lys Thr
    530                 535                 540                 
Met Lys Glu Tyr Thr Thr Leu Leu Phe Val Gly Ser Ser Pro Met
545                 550                 555                 


<210> 397
<211> 829
<212> PRT
<213> Croton sublyratus

<220> 
<223> copalyl diphosphate Acc. No. BAA95612

<400> 397
Met Ser Ser Gln Ala Phe Ser Leu Leu Ser Ser Leu Pro Ser Ser Ser
 1               5                  10                  15      
Phe Ser Ser Thr Arg Pro Arg Leu Phe Leu Gly Val Trp Tyr Glu Leu
            20                  25                  30          
Gln Gly Gln Arg Ile Ser Phe Asn Leu Arg Pro Arg Cys Thr Asp Leu
        35                  40                  45              
Ser Ile Thr Tyr Thr Asn Glu Tyr Val His Gly Glu Met Ala Val Ile
    50                  55                  60                  
Asn Pro Pro Glu Asp Asp Thr Glu Glu Gln Val Pro Lys Val Thr Asn
65                  70                  75                  80  
Ser Ile Cys Val Lys Phe Asn Asn Lys Glu Lys Lys Ser Tyr Ile Tyr
                85                  90                  95      
Asp Tyr Glu Tyr Asn Leu Ile Leu Lys Leu Leu Ile Lys Val Ala Ile
            100                 105                 110         
Ser Lys Glu Ile Met Arg Ser Val Glu Arg Ile Lys Lys Met Leu Lys
        115                 120                 125             
Ser Met Glu Asp Gly Glu Ile Asn Ile Ser Ala Tyr Asp Thr Ala Trp
    130                 135                 140                 
Val Arg Leu Val Lys Asp Val Asn Gly Ser Gly Glu Pro Gln Phe Pro
145                 150                 155                 160 
Ser Ala Leu Gln Trp Ile Ser Asn Asn Gln Leu Pro Asp Gly Ser Trp
                165                 170                 175     
Gly Asp Ala Leu Val Phe Asn Ala His Asp Arg Ile Leu Ser Thr Leu
            180                 185                 190         
Ala Cys Val Val Thr Leu Lys Ser Trp Asn Leu His Pro His Lys Val
        195                 200                 205             
Ala Lys Gly Leu Lys Phe Phe Lys Glu Asn Leu Ser Lys Leu Glu Glu
    210                 215                 220                 
Glu Asn Glu Glu His Met Ser Ile Gly Phe Glu Val Val Phe Pro Ser
225                 230                 235                 240 
Leu Leu Glu Leu Ala Arg Lys Leu Asp Ile Asp Val Pro Asp Asp Ser
                245                 250                 255     
His Val Leu Gln Gln Ile Cys Glu Cys Arg Asn Thr Lys Leu Lys Lys
            260                 265                 270         
Ile Pro Lys Asp Ile Met His Lys Met Pro Thr Ser Leu Leu His Ser
        275                 280                 285             
Leu Glu Gly Met Pro Asp Leu Glu Trp Glu Lys Leu Leu Lys Leu Gln
    290                 295                 300                 
Phe Asp Asn Gly Ser Phe Leu Phe Ser Pro Ser Ser Thr Ala Tyr Ala
305                 310                 315                 320 
Phe Met Gln Thr Gln Asp Asp Lys Cys Leu Ile Tyr Leu Asn Arg Ile
                325                 330                 335     
Val Gln Arg Phe Asn Gly Gly Val Pro Asn Val Tyr Pro Val Asp Leu
            340                 345                 350         
Phe Glu His Thr Trp Ala Ala Asp Arg Leu Gln Arg Leu Gly Ile Ser
        355                 360                 365             
Arg Leu Phe Glu Gln Glu Leu Lys Glu Cys Met Asn Tyr Val Ala Arg
    370                 375                 380                 
Tyr Trp Arg Glu Asp Gly Met Cys Trp Ala Arg Asn Ser Asn Val Arg
385                 390                 395                 400 
Asp Val Asp Asp Ser Ser Met Gly Phe Arg Met Leu Arg Leu Tyr Gly
                405                 410                 415     
His Asn Val Ser Ala Asp Val Phe Lys Lys Phe Lys Lys Asp Asp Thr
            420                 425                 430         
Trp Val Cys Met Pro Gly Gln Ser Thr Gln Ala Ile Thr Gly Met Tyr
        435                 440                 445             
Asn Leu Phe Arg Ala Ser Gln Val Leu Phe Pro Gly Glu Met Ile Leu
    450                 455                 460                 
Glu Glu Ala Arg Glu Phe Cys Tyr Asp Phe Leu Arg Glu Lys Gln Ser
465                 470                 475                 480 
Ala Asn Ala Val Val Asp Lys Trp Ile Ile Ser Lys Asp Leu Pro Gly
                485                 490                 495     
Glu Val Ala Tyr Ala Leu Asp Val Pro Trp Phe Ala Ser Leu Pro Thr
            500                 505                 510         
Val Glu Ala Arg Phe Tyr Ile Glu Gln Tyr Gly Gly Asp Asp Asp Val
        515                 520                 525             
Trp Ile Gly Lys Val Leu Tyr Arg Met Pro Phe Val Asn Asn Asn Glu
    530                 535                 540                 
Tyr Leu Glu Leu Ala Lys Phe Asp Tyr Asn Ser Cys Gln Ala Leu His
545                 550                 555                 560 
Arg Ala Glu Trp Asp Asn Phe Gln Lys Trp Tyr Asp Glu Cys Asn Leu
                565                 570                 575     
Gly Asp Phe Gly Val Ser Lys Arg Glu Leu Leu Leu Ala Tyr Tyr Ile
            580                 585                 590         
Ser Ala Ala Ser Ile Phe Glu Pro Glu Lys Ser Lys Glu Arg Leu Ala
        595                 600                 605             
Trp Ala Lys Thr Ser Ile Leu Leu Gln Thr Ile Asp Ala Tyr Phe His
    610                 615                 620                 
Thr Asn Asn Ser Ile Glu Glu Arg Lys Asp Phe Val His Gln Phe Asn
625                 630                 635                 640 
Met Glu Leu Leu Leu Pro His Leu Glu Trp Asn Arg Gln Glu Asn Gly
                645                 650                 655     
Arg Glu Asp Lys Ala Gly Thr Cys Arg Asn Tyr Thr Trp Asn Leu Lys
            660                 665                 670         
Arg Cys Pro Leu Asp Ala Leu Val Ala His Gly Thr Asp Ile Ser His
        675                 680                 685             
Ser Leu Arg His Ala Trp Glu Ile Gly Leu Thr Asn Trp Glu Lys Asp
    690                 695                 700                 
Gly Asp Lys His Arg Gly Lys Ala Glu Leu Ile Val Lys Thr Ile Asn
705                 710                 715                 720 
Leu Thr Thr Gly Pro Trp Val Ser Glu Glu Leu Leu Asn Cys Asn Ser
                725                 730                 735     
Lys Tyr Glu Lys Leu Phe Gln Leu Ser Asn Tyr Leu Tyr His Gln Leu
            740                 745                 750         
Gly His Phe Asn Lys Asn Lys Val Asp Asp Lys Lys Lys Tyr Thr Thr
        755                 760                 765             
Pro Glu Ile Glu Ser Ser Met Gln Glu Leu Ala Gln Leu Val Leu Gln
    770                 775                 780                 
Asn Ser Ser Asp Gly Leu Asp Ser Asn Ile Lys Gln Thr Phe Phe Thr
785                 790                 795                 800 
Val Val Lys Ser Ile Tyr Tyr Thr Thr Val Cys Asp Leu Gly Thr Thr
                805                 810                 815     
Asn Tyr His Met Ser Lys Val Leu Phe Glu Arg Val Tyr
            820                 825                 


<210> 398
<211> 789
<212> PRT
<213> Cucurbita maxima

<220> 
<223> ent-kaurene synthase B Acc. No. AAB39482

<400> 398
Met Tyr Leu Ser Arg Pro Thr Gly Val Ala Arg Phe Ala Ala Ser Ser
 1               5                  10                  15      
Ser Ser Ser Ser Ser Ala Ser Leu Phe Pro Gly Val Asp Val Asp Thr
            20                  25                  30          
Thr Thr Lys Thr Gly Ala Leu His Phe Glu Glu Thr Lys Glu Arg Ile
        35                  40                  45              
Lys Lys Leu Phe Asp Lys Val Glu Leu Ser Val Ser Ala Tyr Asp Thr
    50                  55                  60                  
Ala Trp Val Ala Met Val Pro Ser Pro Asn Ser Leu Asn Gln Pro Leu
65                  70                  75                  80  
Phe Pro Glu Cys Ile Asn Trp Val Leu Asp Ser Gln His Ala Asp Gly
                85                  90                  95      
Ser Trp Gly Leu Leu His Asn Asp Gln Leu Leu Met Lys Ala Asn Leu
            100                 105                 110         
Leu Ser Thr Leu Ala Cys Val Leu Thr Leu Lys Arg Trp Asn Ile Gly
        115                 120                 125             
His Asp His Met Ser Lys Ala Leu Asp Phe Ile Lys Ser Asn Ile Ala
    130                 135                 140                 
Ser Ala Thr Asp Glu Asn Gln Arg Ser Pro Val Gly Phe Asp Ile Ile
145                 150                 155                 160 
Phe Pro Gly Met Ile Glu Tyr Ala Lys Asp Leu Asn Leu Asn Leu Pro
                165                 170                 175     
Leu Ala Pro Thr Asn Val Asp Ala Leu Val Arg Lys Lys Glu Leu Glu
            180                 185                 190         
Leu Arg Ser Cys Arg Ser Asn Ser Glu Gly Gly Lys Ala Tyr Leu Ala
        195                 200                 205             
Tyr Val Ser Glu Gly Ile Gly Lys Leu Gln Asp Trp Asp Met Val Met
    210                 215                 220                 
Gln Tyr Gln Arg Lys Asn Gly Ser Leu Phe Asn Ser Pro Ser Thr Thr
225                 230                 235                 240 
Ala Ala Ala Phe Met His Arg Asn Asp Asp Gly Cys Phe Asp Tyr Leu
                245                 250                 255     
Arg Ser Leu Leu Gln Lys Phe Asp Gly Ser Val Pro Thr Ile Tyr Pro
            260                 265                 270         
Leu Asp Ile Tyr Ala Arg Leu His Met Val Asp Ser Leu Gln Lys Phe
        275                 280                 285             
Gly Ile Ala Arg His Phe Lys Glu Glu Ile Arg Ser Val Leu Asp Glu
    290                 295                 300                 
Thr Tyr Arg Cys Trp Met Gln Gly Glu Glu Asn Ile Phe Leu Asp Ala
305                 310                 315                 320 
Ser Thr Cys Ala Met Ala Phe Arg Met Leu Arg Val Glu Gly Tyr Asp
                325                 330                 335     
Val Ser Ser Asp Gln Leu Thr Gln Phe Ser Glu Asp Ile Phe Pro Asn
            340                 345                 350         
Cys Leu Gly Gly Tyr Leu Lys Asp Phe Gly Ala Ser Leu Glu Leu Tyr
        355                 360                 365             
Lys Ala Ser Gln Ile Ile Thr His Pro Asp Glu Ser Val Leu Glu Asn
    370                 375                 380                 
Ile Asn Ser Trp Thr Ser Arg Phe Leu Lys His Gly Leu Ser Ser Asp
385                 390                 395                 400 
Ser Val Trp Ser Asp Arg Thr Asp Ser Val Val Lys Gln Glu Ala Val
                405                 410                 415     
Asn Ala Leu Glu Phe Pro Tyr Asn Ala Thr Leu Glu Arg Leu Ile Ser
            420                 425                 430         
Lys Arg Ala Met Glu Ser Tyr Ser Gly Asp Ile Val Arg Ile Ser Lys
        435                 440                 445             
Ser Pro Tyr Ala Cys Leu Asn Phe Gly His Gln Asp Phe Leu Glu Leu
    450                 455                 460                 
Ala Val Glu Asp Phe Asn Thr Leu Gln Arg Ile His Leu Lys Glu Leu
465                 470                 475                 480 
Glu Glu Leu Gln Arg Trp Val Val Glu Asn Lys Leu Asp Glu Leu Lys
                485                 490                 495     
Phe Phe Arg Leu His Leu Gly Tyr Cys Tyr Phe Ala Ala Ala Ala Thr
            500                 505                 510         
Leu Thr Asp Pro Glu Leu His Asp Ala Arg Ile Ala Trp Ala Gln Asn
        515                 520                 525             
Gly Val Leu Thr Thr Val Val Asp Asp Phe Tyr Asp Gly Gly Gly Ser
    530                 535                 540                 
Glu Glu Glu Leu Asp Asn Leu Ile Glu Leu Val Glu Lys Trp Asp Pro
545                 550                 555                 560 
Asp Gly Glu Val Gly Tyr Cys Ser Lys Asp Val Glu Ile Val Phe Leu
                565                 570                 575     
Ala Leu His Ser Thr Val Cys Glu Ile Gly Arg Arg Ala Leu Val Trp
            580                 585                 590         
Gln Gly Arg Ser Val Met Arg Asn Val Ile Asp Gly Trp Leu Ala Leu
        595                 600                 605             
Leu Lys Val Met Arg Lys Glu Ala Glu Trp Ser Thr Asn Lys Val Val
    610                 615                 620                 
Pro Ser Met Gly Glu Tyr Met Glu Gln Ala His Val Ser Phe Ala Leu
625                 630                 635                 640 
Gly Pro Ile Ile Leu Pro Met Leu Phe Phe Val Gly Pro Lys Leu Ser
                645                 650                 655     
Glu Glu Met Ile Gly Ser Cys Glu Tyr Gln Lys Leu Tyr Lys Leu Met
            660                 665                 670         
Ser Thr Ala Gly Arg Leu Lys Asn Asp Ile Arg Ser Tyr Asp Arg Glu
        675                 680                 685             
Cys Lys Glu Gly Lys Leu Asn Ile Leu Ser Leu Trp Met Ile Asp Gly
    690                 695                 700                 
Gly Gly Asn Val Thr Lys Glu Glu Ala Ile Glu Ala Ile Lys Gly Asp
705                 710                 715                 720 
Phe Glu Arg Ala Ile Arg Glu Leu Leu Gly Leu Val Leu Gln Glu Asn
                725                 730                 735     
Thr Thr Ile Pro Arg Ala Cys Lys Asp Leu Phe Trp Lys Leu Met Ser
            740                 745                 750         
Ile Val Asn Leu Phe Tyr Met Glu Asp Asp Gly Tyr Thr Ser Asn Arg
        755                 760                 765             
Leu Met Asn Thr Val Lys Ala Met Phe Glu Gln Pro Met Asp Leu Asp
    770                 775                 780                 
Ala Leu Leu Asn Lys
785                 


<210> 399
<211> 827
<212> PRT
<213> Cucurbita maxima

<220> 
<223> copalyl diphospahte synthase 2 Acc. No. AAD04293

<400> 399
Met Ser Ser Ser Ser Ser Leu Ser Leu Ser Arg His Cys Leu Ser Ser
 1               5                  10                  15      
Ser Phe Ser Phe Arg Leu Pro Asn Leu Phe Pro Pro Pro Ala Pro Gly
            20                  25                  30          
Gly Cys Ser Leu Arg Val Lys Asp Lys Gly Ala Val Leu Glu Ser Ser
        35                  40                  45              
Ile Arg Cys Ile Ile Lys Cys Asn Ala Ile Ser Lys Pro Pro Thr Gln
    50                  55                  60                  
Asp Tyr Ser Asp Val Leu Gln Ser Gly Val Pro Leu Leu Lys Trp Gln
65                  70                  75                  80  
Gln Phe Val Glu Glu Gly Ile Glu Ser Glu Thr Ala Ala Gln Val Ser
                85                  90                  95      
Val Trp Glu Glu Ile Glu Glu Arg Val Lys Trp Ile Lys Ser Met Leu
            100                 105                 110         
Ser Ser Met Asp Asp Gly Asp Ile Ser Ile Ser Ala Tyr Asp Thr Ala
        115                 120                 125             
Trp Val Ala Leu Ile Pro Lys Val Thr Glu Glu Gly Val Lys Ser Pro
    130                 135                 140                 
Gln Phe Pro Ser Ser Leu Glu Trp Ile Ala Asn Asn Gln Leu Pro Asp
145                 150                 155                 160 
Gly Ser Trp Gly Asp Ala Gln Ile Phe Ser Pro His Asp Arg Ile Ile
                165                 170                 175     
Asn Thr Leu Ala Ser Leu Val Ala Leu Lys Ser Trp Asn Leu His Pro
            180                 185                 190         
Gln Asn Thr Arg Lys Gly Val Ala Phe Phe Asn Gln Asn Ile Trp Lys
        195                 200                 205             
Leu Glu Glu Glu Asn Ala Glu His Met Pro Ile Gly Phe Glu Ile Ala
    210                 215                 220                 
Phe Pro Ser Leu Leu Glu Phe Ala Lys Lys Leu Lys Leu Gly Ile Arg
225                 230                 235                 240 
Ser Asp Ser Pro Ala Leu Gln Gln Ile Asn Ala Arg Arg Arg Leu Lys
                245                 250                 255     
Leu Ala Arg Ile Pro Lys Asp Ile Met His Lys Leu Pro Thr Thr Leu
            260                 265                 270         
Leu His Ser Leu Glu Gly Met Ser Gly Leu Asp Trp Glu Lys Leu Leu
        275                 280                 285             
Lys Leu Gln Ser Gln Asp Gly Ser Phe Leu Ser Ser Pro Ala Ser Thr
    290                 295                 300                 
Ala Phe Ala Leu Met His Thr Asn His Pro Asn Cys Phe Lys Tyr Leu
305                 310                 315                 320 
Glu Ala Ser Val His Arg Phe Asn Gly Gly Val Pro Asn Val Tyr Pro
                325                 330                 335     
Val Asp Leu Phe Glu His Ile Trp Ala Val Asp Arg Leu Gln Arg Leu
            340                 345                 350         
Gly Ile Ser Arg Phe Phe His Pro His Ile Val Glu Cys Val Asn Asn
        355                 360                 365             
Val Arg Thr His Trp Ser Glu Lys Gly Ile Cys Trp Ala Arg Asn Ser
    370                 375                 380                 
Glu Phe Arg Asp Ile Asp Asp Thr Ala Met Gly Phe Arg Leu Leu Arg
385                 390                 395                 400 
Leu Tyr Gly His Asp Val Ser Ala Glu Val Phe Lys His Phe Glu Lys
                405                 410                 415     
Asp Gly Glu Phe Val Cys Ile Ala Gly Gln Ser Thr Gln Ala Val Thr
            420                 425                 430         
Gly Met Leu Asn Leu Tyr Arg Ala Ser Asp Gln Val Met Phe Pro Gly
        435                 440                 445             
Glu Lys Ile Leu Glu Asp Ala Lys Gln Phe Ala Ser Lys Phe Leu Arg
    450                 455                 460                 
Gln Lys Gln Ala Ala Asn Gln Leu Leu Asp Lys Trp Ile Ile Ala Lys
465                 470                 475                 480 
Asp Leu Pro Gly Glu Val Gly Tyr Ala Leu Asp Val Pro Trp Phe Ala
                485                 490                 495     
Ser Leu Pro Arg Val Glu Thr Arg Leu Tyr Ile Gln His Tyr Gly Gly
            500                 505                 510         
Lys Asn Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met Phe Lys Val
        515                 520                 525             
Asn Asn Asp Thr Tyr Leu Glu Leu Ala Lys Leu Asp Tyr Asn Asn Cys
    530                 535                 540                 
Gln Arg Leu His Gln Ile Glu Trp Val Asp Ile Gln Lys Trp Tyr Thr
545                 550                 555                 560 
Glu Ser Lys Leu Arg Asp Tyr Gly Met Arg Arg Ser Ser Ile Leu Phe
                565                 570                 575     
Ser Tyr Phe Gly Ala Val Cys Ser Ile Phe Glu Pro Glu Arg Ala Lys
            580                 585                 590         
Glu Arg Leu Ala Trp Thr Lys Thr Ala Ala Leu Val His Thr Ile Ala
        595                 600                 605             
Ser His Tyr Lys Asp Ala Asn Ala His Gln Arg Arg Ala Phe Leu Gln
    610                 615                 620                 
Gln Phe Thr Asn Phe His Ala Ala Gln Pro Tyr Asp Asn Asn Ala Trp
625                 630                 635                 640 
Arg Ser Gly Asn Met Gln Gln Lys Gly Gly Glu Gly Leu Val Gly Ile
                645                 650                 655     
Leu Leu Arg Thr Leu Thr Asn Ile Ser Leu Asp Ile Leu Leu Ser His
            660                 665                 670         
Gly Val Asp Ile Thr His His Leu His Gln Ala Trp Gln Lys Trp Val
        675                 680                 685             
Phe Lys Trp Gln Glu Asp Gly Asp Val His Lys Glu Glu Ala Glu Leu
    690                 695                 700                 
Leu Val Gln Thr Ile Ile Leu Asn Ser Gly Cys Ser Thr Leu Glu Asp
705                 710                 715                 720 
Leu Leu Ser Asn Ser Gln Phe Gln Lys Leu Ser Asn Leu Thr Asn Lys
                725                 730                 735     
Val Cys His Gln Leu Ala His Phe Lys Lys His Lys Val Asn Asn Gly
            740                 745                 750         
Asn Leu Tyr Lys Glu Lys Thr Asp Asn Lys Met Pro Pro Glu Ile Glu
        755                 760                 765             
Glu Asp Ile Arg Lys Leu Val Gln Leu Val Ile Gln Lys Ser Ser Asp
    770                 775                 780                 
Gly Asn Asp Ile Asp Ser Pro Ile Lys Gln Thr Phe Leu Thr Val Ala
785                 790                 795                 800 
Lys Ser Val Tyr Tyr Ala Ala Tyr Phe Asp Ala Trp Thr Ile Asn Tyr
                805                 810                 815     
His Ile Ala Lys Val Leu Phe Glu Arg Val Phe
            820                 825         


<210> 400
<211> 571
<212> PRT
<213> Cucumis melo

<220> 
<223> terpene synthase Acc. No. ABX83200

<400> 400
Met Ser Ser Gln Val Ser Asn Phe Pro Ala Ser Ile Met Lys Thr Asn
 1               5                  10                  15      
Asp Ile Pro Asp Val Lys Arg Ser Leu Ala Asn Phe His Pro Asn Ile
            20                  25                  30          
Trp Lys Glu His Phe Leu Ser Phe Thr Phe Asp Asp Ala Leu Lys Ile
        35                  40                  45              
Asp Glu Gly Met Lys Glu Arg Thr Glu Lys Leu Lys Glu Glu Ile Arg
    50                  55                  60                  
Met Met Met Ile Ala Tyr Val Glu Asn Gln Leu Ile Lys Leu Asn Leu
65                  70                  75                  80  
Val Asp Ser Ile Gln Arg Leu Gly Val Ser Tyr His Phe Glu Asp Glu
                85                  90                  95      
Val Asp Glu Phe Leu Glu His Ile Tyr Val Ser Tyr Asn Asn Ser Leu
            100                 105                 110         
Leu Leu Ser Asn Lys Asn Ser Asn Gly Glu Asp Leu His Ile Thr Ala
        115                 120                 125             
Leu Leu Phe Arg Leu Leu Arg Gln Gln Gly Tyr Arg Ile Ser Cys Asp
    130                 135                 140                 
Ile Phe Leu Lys Phe Met Asp Asp Asn Gly Lys Phe Lys Glu Ser Leu
145                 150                 155                 160 
Val Glu Asp Glu Arg Gly Leu Leu Ser Leu Tyr Glu Ala Ser His Met
                165                 170                 175     
Met Gly His Gly Glu Ala Leu Leu Glu Glu Ala Leu Glu Phe Thr Thr
            180                 185                 190         
Thr His Leu Gln Thr Tyr Ile His Arg Tyr Ser Asn Ile Asn Pro Ser
        195                 200                 205             
Phe Ala Ser Glu Val Ser Asn Ala Leu Lys Leu Pro Ile Arg Lys Ser
    210                 215                 220                 
Val Pro Arg Ile Lys Ala Arg Glu Tyr Leu Glu Ile Tyr Gln Gln His
225                 230                 235                 240 
Pro Ser His Asn Glu Thr Leu Leu Glu Phe Ser Lys Leu Asp Phe Asn
                245                 250                 255     
Ile Leu Gln Lys Leu His Gln Lys Glu Leu Ser Glu Ile Cys Arg Trp
            260                 265                 270         
Trp Lys Asp Leu Asp Val Pro Thr Lys Phe Pro Phe Ala Arg Asp Arg
        275                 280                 285             
Ile Val Glu Cys Tyr Phe Trp Thr Leu Gly Ala Tyr Phe Glu Pro Gln
    290                 295                 300                 
Tyr Ser Val Gly Arg Lys Met Leu Thr Lys Val Ile Ala Ile Ala Ser
305                 310                 315                 320 
Ile Leu Asp Asp Ile Tyr Asp Ala Tyr Gly Thr Phe Glu Glu Leu Gln
                325                 330                 335     
Val Leu Thr Pro Ala Ile Gln Arg Trp Asp Arg Ser Met Val His Thr
            340                 345                 350         
Leu Pro Leu Tyr Met Lys Pro Phe Tyr Val Ala Met Leu Glu Leu Tyr
        355                 360                 365             
Glu Glu Ile Gly Lys Glu Ile Asp Lys Asp Gln Asn Ser Leu His Leu
    370                 375                 380                 
Gln Val Ala Ile Gly Gly Ile Lys Arg Leu Ser Glu Ser Tyr Phe Glu
385                 390                 395                 400 
Glu Ala Lys Trp Leu Asn Lys Glu Tyr Lys Pro Ser Phe Lys Glu Tyr
                405                 410                 415     
Met Glu Leu Ala Leu Lys Thr Thr Gly Tyr Thr Met Leu Ile Ser Ile
            420                 425                 430         
Ser Phe Leu Gly Leu Gly Asp His Ile Val Thr Asn Glu Val Leu Gln
        435                 440                 445             
Trp Leu Ser Asn Gly Pro Gln Ile Ile Lys Ala Ser Thr Ile Ile Cys
    450                 455                 460                 
Arg Leu Met Asp Asp Ile Ala Ser His Lys Phe Glu Gln Glu Arg Glu
465                 470                 475                 480 
His Val Ala Ser Ala Val Glu Cys Tyr Met Lys Gln Tyr Asp Cys Ser
                485                 490                 495     
Glu Glu Glu Ala Cys Ile Glu Leu His Lys Glu Val Val Asp Ala Trp
            500                 505                 510         
Lys Asp Thr Asn Glu Ala Phe Tyr Arg Pro Phe Asn Val Pro Val Pro
        515                 520                 525             
Val Leu Met Arg Val Leu Asn Phe Ser Arg Val Ile Asn Leu Leu Tyr
    530                 535                 540                 
Leu Asp Glu Asp Gly Tyr Thr Asn Ala Lys Ser Gly Thr Lys Phe Leu
545                 550                 555                 560 
Ile Lys Ser Leu Leu Val Asp Pro Leu Pro Cys
                565                 570     


<210> 401
<211> 561
<212> PRT
<213> Elaeis oleifera

<220> 
<223> sesquiterpene synthase Acc. No. AAC31570

<400> 401
Met Ser Ser Asn Thr Met Glu Ala His Gly Ser Thr Asn His Ser Ser
 1               5                  10                  15      
Val Pro Cys Gly Gly Asp Gly Thr Ile Arg Phe Leu Ala Asn Phe His
            20                  25                  30          
Pro Thr Ile Trp Gly Asp Tyr Phe Ile Glu Asn Tyr Pro Leu Pro Ser
        35                  40                  45              
Asn Leu Gln Lys Ser Glu Ala Cys Ile Glu Lys Arg Arg Glu Glu Leu
    50                  55                  60                  
Lys Val Glu Val Met Asn Leu Leu Lys Asn Ala Asn Asp Tyr Leu Gln
65                  70                  75                  80  
Glu Met Glu Leu Ile Asp Ile Leu Gln Arg Leu Gly Val Ala Tyr His
                85                  90                  95      
Phe Glu Lys Lys Ile Asp Glu Ile Leu Ser Gln Ile Phe Lys Glu His
            100                 105                 110         
Met Glu Asp Asp Asn Leu His Ala Val Ala Leu Arg Phe Arg Leu Leu
        115                 120                 125             
Arg Gln His Gly Tyr Asn Met Pro Thr Asn Ile Phe Ile Lys Phe Lys
    130                 135                 140                 
Glu Val Asp Gly Ser Phe Lys Ala Thr Leu Arg Asn Asp Val Lys Gly
145                 150                 155                 160 
Leu Leu Ser Leu Tyr Glu Ala Ala Tyr Leu Gly Ile Pro Lys Asp Asn
                165                 170                 175     
Leu Leu Asp Glu Ala Leu Asn Phe Ala Lys Leu His Leu Lys Ser Met
            180                 185                 190         
Glu Ser His Met Lys Thr Pro Leu Ala Val Arg Val Leu Asp Ala Phe
        195                 200                 205             
Glu Met Pro Leu His Arg Arg Thr Thr Arg Leu Glu Ala Lys Asn Tyr
    210                 215                 220                 
Ile Ser Ile Tyr Gln Gln Asp Asp Gly Arg Ile Asn Val Val Leu Glu
225                 230                 235                 240 
Leu Ala Lys Leu Asp Phe His Ile Leu Gln Ser Ile His Arg Glu Glu
                245                 250                 255     
Val Arg Ser Ile Ser Met Trp Trp Lys Ala Leu Gly Leu Ala Lys Lys
            260                 265                 270         
Leu Thr Phe Cys Arg Asp Arg Val Val Glu Gly Tyr Phe Trp Ile Leu
        275                 280                 285             
Gly Val Tyr Phe Glu Pro Gln Tyr Ser Arg Ala Arg Ile Tyr Leu Thr
    290                 295                 300                 
Lys Val Leu Ala Leu Leu Ser Ile Met Asp Asp Ile Tyr Asp Thr Tyr
305                 310                 315                 320 
Gly Ile Ala Glu Glu Leu Gln Ala Phe Thr Glu Val Ile Arg Arg Trp
                325                 330                 335     
Asp Ile Glu Ala Val Asp Gln Leu Asp Glu Val Tyr Lys Leu Tyr Phe
            340                 345                 350         
Leu Asn Leu Tyr Asn Thr Phe Lys Glu Phe Glu Asp Glu Leu Ala Lys
        355                 360                 365             
Glu Gly Asn Ser Tyr Arg Val Glu Tyr Leu Lys Glu Ser Val Lys Glu
    370                 375                 380                 
Leu Ser Arg Ala Tyr Leu Glu Glu Val Lys Trp Arg Asp Glu Gly Tyr
385                 390                 395                 400 
Val Pro Pro Leu Lys Glu Tyr Leu Asn Val Ser Gln Ile Ser Thr Val
                405                 410                 415     
His Val Ala Leu Ser Cys Ala Ser Phe Val Gly Met Gly Glu Glu Ala
            420                 425                 430         
Thr Lys Glu Ala Phe Asp Trp Val Thr Ser Phe Pro Arg Ile Ile Lys
        435                 440                 445             
Ser Ser Cys Leu Ile Gly Arg Leu Leu Asp Asp Val Ala Ser Asn Glu
    450                 455                 460                 
Phe Glu His Glu Arg Lys His Val Ser Ser Ala Val His Cys Tyr Ile
465                 470                 475                 480 
Lys Glu His Gly Thr Ser Val Gln Glu Ala Tyr Glu Lys Leu Arg Gly
                485                 490                 495     
Met Ile Glu Asp Glu Trp Lys Ile Met Asn Gln Glu Tyr Leu Cys Met
            500                 505                 510         
Thr Thr Met Pro Met Ser Leu Ile Arg Pro Ile Ile Asn Leu Pro Arg
        515                 520                 525             
Met Ala Glu Thr Val Tyr Lys Lys Cys Asp Ser Tyr Thr His Ser Leu
    530                 535                 540                 
Ser Thr Met Lys Asp Tyr Ile Met Ser Leu Leu Val Glu Pro Ile Ser
545                 550                 555                 560 
Phe
    


<210> 402
<211> 873
<212> PRT
<213> Ginkgo biloba

<220> 
<223> levopimaradiene synthase Acc. No. AAL09965

<400> 402
Met Ala Gly Val Leu Phe Ala Asn Leu Pro Cys Ser Leu Gln Leu Ser
 1               5                  10                  15      
Pro Lys Val Pro Phe Arg Gln Ser Thr Asn Ile Leu Ile Pro Phe His
            20                  25                  30          
Lys Arg Ser Ser Phe Gly Phe Asn Ala Gln His Cys Val Arg Ser His
        35                  40                  45              
Leu Arg Leu Arg Trp Asn Cys Val Gly Ile His Ala Ser Ala Ala Glu
    50                  55                  60                  
Thr Arg Pro Asp Gln Leu Pro Gln Glu Glu Arg Phe Val Ser Arg Leu
65                  70                  75                  80  
Asn Ala Asp Tyr His Pro Ala Val Trp Lys Asp Asp Phe Ile Asp Ser
                85                  90                  95      
Leu Thr Ser Pro Asn Ser His Ala Thr Ser Lys Ser Ser Val Asp Glu
            100                 105                 110         
Thr Ile Asn Lys Arg Ile Gln Thr Leu Val Lys Glu Ile Gln Cys Met
        115                 120                 125             
Phe Gln Ser Met Gly Asp Gly Glu Thr Asn Pro Ser Ala Tyr Asp Thr
    130                 135                 140                 
Ala Trp Val Ala Arg Ile Pro Ser Ile Asp Gly Ser Gly Ala Pro Gln
145                 150                 155                 160 
Phe Pro Gln Thr Leu Gln Trp Ile Leu Asn Asn Gln Leu Pro Asp Gly
                165                 170                 175     
Ser Trp Gly Glu Glu Cys Ile Phe Leu Ala Tyr Asp Arg Val Leu Asn
            180                 185                 190         
Thr Leu Ala Cys Leu Leu Thr Leu Lys Ile Trp Asn Lys Gly Asp Ile
        195                 200                 205             
Gln Val Gln Lys Gly Val Glu Phe Val Arg Lys His Met Glu Glu Met
    210                 215                 220                 
Lys Asp Glu Ala Asp Asn His Arg Pro Ser Gly Phe Glu Val Val Phe
225                 230                 235                 240 
Pro Ala Met Leu Asp Glu Ala Lys Ser Leu Gly Leu Asp Leu Pro Tyr
                245                 250                 255     
His Leu Pro Phe Ile Ser Gln Ile His Gln Lys Arg Gln Lys Lys Leu
            260                 265                 270         
Gln Lys Ile Pro Leu Asn Val Leu His Asn His Gln Thr Ala Leu Leu
        275                 280                 285             
Tyr Ser Leu Glu Gly Leu Gln Asp Val Val Asp Trp Gln Glu Ile Thr
    290                 295                 300                 
Asn Leu Gln Ser Arg Asp Gly Ser Phe Leu Ser Ser Pro Ala Ser Thr
305                 310                 315                 320 
Ala Cys Val Phe Met His Thr Gln Asn Lys Arg Cys Leu His Phe Leu
                325                 330                 335     
Asn Phe Val Leu Ser Lys Phe Gly Asp Tyr Val Pro Cys His Tyr Pro
            340                 345                 350         
Leu Asp Leu Phe Glu Arg Leu Trp Ala Val Asp Thr Val Glu Arg Leu
        355                 360                 365             
Gly Ile Asp Arg Tyr Phe Lys Lys Glu Ile Lys Glu Ser Leu Asp Tyr
    370                 375                 380                 
Val Tyr Arg Tyr Trp Asp Ala Glu Arg Gly Val Gly Trp Ala Arg Cys
385                 390                 395                 400 
Asn Pro Ile Pro Asp Val Asp Asp Thr Ala Met Gly Leu Arg Ile Leu
                405                 410                 415     
Arg Leu His Gly Tyr Asn Val Ser Ser Asp Val Leu Glu Asn Phe Arg
            420                 425                 430         
Asp Glu Lys Gly Asp Phe Phe Cys Phe Ala Gly Gln Thr Gln Ile Gly
        435                 440                 445             
Val Thr Asp Asn Leu Asn Leu Tyr Arg Cys Ser Gln Val Cys Phe Pro
    450                 455                 460                 
Gly Glu Lys Ile Met Glu Glu Ala Lys Thr Phe Thr Thr Asn His Leu
465                 470                 475                 480 
Gln Asn Ala Leu Ala Lys Asn Asn Ala Phe Asp Lys Trp Ala Val Lys
                485                 490                 495     
Lys Asp Leu Pro Gly Glu Val Glu Tyr Ala Ile Lys Tyr Pro Trp His
            500                 505                 510         
Arg Ser Met Pro Arg Leu Glu Ala Arg Ser Tyr Ile Glu Gln Phe Gly
        515                 520                 525             
Ser Asn Asp Val Trp Leu Gly Lys Thr Val Tyr Lys Met Leu Tyr Val
    530                 535                 540                 
Ser Asn Glu Lys Tyr Leu Glu Leu Ala Lys Leu Asp Phe Asn Met Val
545                 550                 555                 560 
Gln Ala Leu His Gln Lys Glu Thr Gln His Ile Val Ser Trp Trp Arg
                565                 570                 575     
Glu Ser Gly Phe Asn Asp Leu Thr Phe Thr Arg Gln Arg Pro Val Glu
            580                 585                 590         
Met Tyr Phe Ser Val Ala Val Ser Met Phe Glu Pro Glu Phe Ala Ala
        595                 600                 605             
Cys Arg Ile Ala Tyr Ala Lys Thr Ser Cys Leu Ala Val Ile Leu Asp
    610                 615                 620                 
Asp Leu Tyr Asp Thr His Gly Ser Leu Asp Asp Leu Lys Leu Phe Ser
625                 630                 635                 640 
Glu Ala Val Arg Arg Trp Asp Ile Ser Val Leu Asp Ser Val Arg Asp
                645                 650                 655     
Asn Gln Leu Lys Val Cys Phe Leu Gly Leu Tyr Asn Thr Val Asn Gly
            660                 665                 670         
Phe Gly Lys Asp Gly Leu Lys Glu Gln Gly Arg Asp Val Leu Gly Tyr
        675                 680                 685             
Leu Arg Lys Val Trp Glu Gly Leu Leu Ala Ser Tyr Thr Lys Glu Ala
    690                 695                 700                 
Glu Trp Ser Ala Ala Lys Tyr Val Pro Thr Phe Asn Glu Tyr Val Glu
705                 710                 715                 720 
Asn Ala Lys Val Ser Ile Ala Leu Ala Thr Val Val Leu Asn Ser Ile
                725                 730                 735     
Phe Phe Thr Gly Glu Leu Leu Pro Asp Tyr Ile Leu Gln Gln Val Asp
            740                 745                 750         
Leu Arg Ser Lys Phe Leu His Leu Val Ser Leu Thr Gly Arg Leu Ile
        755                 760                 765             
Asn Asp Thr Lys Thr Tyr Gln Ala Glu Arg Asn Arg Gly Glu Leu Val
    770                 775                 780                 
Ser Ser Val Gln Cys Tyr Met Arg Glu Asn Pro Glu Cys Thr Glu Glu
785                 790                 795                 800 
Glu Ala Leu Ser His Val Tyr Gly Ile Ile Asp Asn Ala Leu Lys Glu
                805                 810                 815     
Leu Asn Trp Glu Leu Ala Asn Pro Ala Ser Asn Ala Pro Leu Cys Val
            820                 825                 830         
Arg Arg Leu Leu Phe Asn Thr Ala Arg Val Met Gln Leu Phe Tyr Met
        835                 840                 845             
Tyr Arg Asp Gly Phe Gly Ile Ser Asp Lys Glu Met Lys Asp His Val
    850                 855                 860                 
Ser Arg Thr Leu Phe Asp Pro Val Ala
865                 870             


<210> 403
<211> 555
<212> PRT
<213> Gossypium arboreum

<220> 
<223> (+)-delta-cadinene synthase Acc. No. CAA77191

<400> 403
Met Ala Ser Gln Ala Ser Gln Val Leu Ala Ser Pro His Pro Ala Ile
 1               5                  10                  15      
Ser Ser Glu Asn Arg Pro Lys Ala Asp Phe His Pro Gly Ile Trp Gly
            20                  25                  30          
Asp Met Phe Ile Ile Cys Pro Asp Thr Asp Ile Asp Ala Ala Thr Glu
        35                  40                  45              
Leu Gln Tyr Glu Glu Leu Lys Ala Gln Val Arg Lys Met Ile Met Glu
    50                  55                  60                  
Pro Val Asp Asp Ser Asn Gln Lys Leu Pro Phe Ile Asp Ala Val Gln
65                  70                  75                  80  
Arg Leu Gly Val Ser Tyr His Phe Glu Lys Glu Ile Glu Asp Glu Leu
                85                  90                  95      
Glu Asn Ile Tyr Arg Asp Thr Asn Asn Asn Asp Ala Asp Thr Asp Leu
            100                 105                 110         
Tyr Thr Thr Ala Leu Arg Phe Arg Leu Leu Arg Glu His Gly Phe Asp
        115                 120                 125             
Ile Ser Cys Asp Ala Phe Asn Lys Phe Lys Asp Glu Ala Gly Asn Phe
    130                 135                 140                 
Lys Ala Ser Leu Thr Ser Asp Val Gln Gly Leu Leu Glu Leu Tyr Glu
145                 150                 155                 160 
Ala Ser Tyr Met Arg Val His Gly Glu Asp Ile Leu Asp Glu Ala Ile
                165                 170                 175     
Ser Phe Thr Thr Ala Gln Leu Thr Leu Ala Leu Pro Thr Leu His His
            180                 185                 190         
Pro Leu Ser Glu Gln Val Gly His Ala Leu Lys Gln Ser Ile Arg Arg
        195                 200                 205             
Gly Leu Pro Arg Val Glu Ala Arg Asn Phe Ile Ser Ile Tyr Gln Asp
    210                 215                 220                 
Leu Glu Ser His Asn Lys Ser Leu Leu Gln Phe Ala Lys Ile Asp Phe
225                 230                 235                 240 
Asn Leu Leu Gln Leu Leu His Arg Lys Glu Leu Ser Glu Ile Cys Arg
                245                 250                 255     
Trp Trp Lys Asp Leu Asp Phe Thr Arg Lys Leu Pro Phe Ala Arg Asp
            260                 265                 270         
Arg Val Val Glu Gly Tyr Phe Trp Ile Met Gly Val Tyr Phe Glu Pro
        275                 280                 285             
Gln Tyr Ser Leu Gly Arg Lys Met Leu Thr Lys Val Ile Ala Met Ala
    290                 295                 300                 
Ser Ile Val Asp Asp Thr Tyr Asp Ser Tyr Ala Thr Tyr Asp Glu Leu
305                 310                 315                 320 
Ile Pro Tyr Thr Asn Ala Ile Glu Arg Trp Asp Ile Lys Cys Met Asn
                325                 330                 335     
Gln Leu Pro Asn Tyr Met Lys Ile Ser Tyr Lys Ala Leu Leu Asp Val
            340                 345                 350         
Tyr Glu Glu Met Glu Gln Leu Leu Ala Asn Gln Gly Arg Gln Tyr Arg
        355                 360                 365             
Val Glu Tyr Ala Lys Lys Ala Met Ile Arg Leu Val Gln Ala Tyr Leu
    370                 375                 380                 
Leu Glu Ala Lys Trp Thr His Gln Asn Tyr Lys Pro Thr Phe Glu Glu
385                 390                 395                 400 
Phe Arg Asp Asn Ala Leu Pro Thr Ser Gly Tyr Ala Met Leu Ala Ile
                405                 410                 415     
Thr Ala Phe Val Gly Met Gly Glu Val Ile Thr Pro Glu Thr Phe Lys
            420                 425                 430         
Trp Ala Ala Ser Asp Pro Lys Ile Ile Lys Ala Ser Thr Ile Ile Cys
        435                 440                 445             
Arg Phe Met Asp Asp Ile Ala Glu His Lys Phe Asn His Arg Arg Glu
    450                 455                 460                 
Asp Asp Cys Ser Ala Ile Glu Cys Tyr Met Lys Gln Tyr Gly Val Thr
465                 470                 475                 480 
Ala Gln Glu Ala Tyr Asn Glu Phe Asn Lys His Ile Glu Ser Ser Trp
                485                 490                 495     
Lys Asp Val Asn Glu Glu Phe Leu Lys Pro Thr Glu Met Pro Thr Pro
            500                 505                 510         
Val Leu Cys Arg Ser Leu Asn Leu Ala Arg Val Met Asp Val Leu Tyr
        515                 520                 525             
Arg Glu Gly Asp Gly Tyr Thr His Val Gly Lys Ala Ala Lys Gly Gly
    530                 535                 540                 
Ile Thr Ser Leu Leu Ile Asp Pro Ile Gln Ile
545                 550                 555 


<210> 404
<211> 554
<212> PRT
<213> Gossypium arboreum

<220> 
<223> (+)-delta-cadinene synthase Acc. No. CAA76223

<400> 404
Met Ala Ser Gln Val Ser Gln Met Pro Ser Ser Ser Pro Leu Ser Ser
 1               5                  10                  15      
Asn Lys Asp Glu Ile Arg Pro Lys Ala Asp Phe Gln Pro Ser Ile Trp
            20                  25                  30          
Gly Asp Phe Phe Leu Asn Cys Pro Asp Lys Asn Ile Asp Ala Gly Thr
        35                  40                  45              
Glu Lys Arg His Gln Gln Leu Lys Glu Glu Val Arg Lys Met Ile Val
    50                  55                  60                  
Ala Pro Met Ala Asn Ser Thr Gln Lys Leu Ala Phe Ile Asp Ser Val
65                  70                  75                  80  
Gln Arg Leu Gly Val Ser Tyr His Phe Thr Lys Glu Ile Glu Asp Glu
                85                  90                  95      
Leu Glu Asn Ile Tyr His Asn Asn Asn Asp Ala Glu Asn Asp Leu Tyr
            100                 105                 110         
Thr Thr Ser Leu Arg Phe Arg Leu Leu Arg Glu His Gly Tyr Asn Val
        115                 120                 125             
Ser Cys Asp Val Phe Asn Lys Phe Lys Asp Glu Gln Gly Asn Phe Lys
    130                 135                 140                 
Ser Ser Val Thr Ser Asp Val Gln Gly Leu Leu Glu Leu Tyr Gln Ala
145                 150                 155                 160 
Ser Tyr Leu Arg Val His Gly Glu Asp Ile Leu Asp Glu Ala Ile Ser
                165                 170                 175     
Phe Thr Thr Asn His Leu Ser Leu Ala Val Ser Ser Leu Asp His Pro
            180                 185                 190         
Leu Ser Glu Glu Val Ser His Ala Leu Lys Gln Ser Ile Arg Arg Gly
        195                 200                 205             
Leu Pro Arg Val Glu Ala Arg His Tyr Leu Ser Val Tyr Gln Asp Ile
    210                 215                 220                 
Glu Ser His Asn Lys Ala Leu Leu Glu Phe Ala Lys Ile Asp Phe Asn
225                 230                 235                 240 
Met Leu Gln Phe Leu His Arg Lys Glu Leu Ser Glu Ile Cys Arg Trp
                245                 250                 255     
Trp Lys Asp Leu Asp Phe Gln Arg Lys Leu Pro Tyr Ala Arg Asp Arg
            260                 265                 270         
Val Val Glu Gly Tyr Phe Trp Ile Ser Gly Val Tyr Phe Glu Pro Gln
        275                 280                 285             
Tyr Ser Leu Gly Arg Lys Met Leu Thr Lys Val Ile Ala Met Ala Ser
    290                 295                 300                 
Ile Val Asp Asp Thr Tyr Asp Ser Tyr Ala Thr Tyr Glu Glu Leu Ile
305                 310                 315                 320 
Pro Tyr Thr Asn Ala Ile Glu Arg Trp Asp Ile Lys Cys Ile Asp Glu
                325                 330                 335     
Leu Pro Glu Tyr Met Lys Pro Ser Tyr Lys Ala Leu Leu Asp Val Tyr
            340                 345                 350         
Lys Glu Met Glu Gln Leu Val Ala Glu His Gly Arg Gln Tyr Arg Val
        355                 360                 365             
Glu Tyr Ala Lys Asn Ala Met Ile Arg Leu Ala Gln Ser Tyr Leu Val
    370                 375                 380                 
Glu Ala Arg Trp Thr Leu Gln Asn Tyr Lys Pro Ser Phe Glu Glu Phe
385                 390                 395                 400 
Lys Ala Asn Ala Leu Pro Thr Cys Gly Tyr Ala Met Leu Ala Ile Thr
                405                 410                 415     
Ser Phe Val Gly Met Gly Asp Ile Val Thr Pro Glu Thr Phe Lys Trp
            420                 425                 430         
Ala Ala Asn Asp Pro Lys Ile Ile Gln Ala Ser Thr Ile Ile Cys Arg
        435                 440                 445             
Phe Met Asp Asp Val Ala Glu His Lys Phe Lys His Arg Arg Glu Asp
    450                 455                 460                 
Asp Cys Ser Ala Ile Glu Cys Tyr Met Glu Glu Tyr Gly Val Ser Ala
465                 470                 475                 480 
Gln Glu Ala Tyr Asp Val Phe Asn Lys His Val Glu Ser Ala Trp Lys
                485                 490                 495     
Asp Val Asn Gln Glu Phe Gln Lys Pro Thr Glu Met Pro Thr Glu Val
            500                 505                 510         
Leu Asn Arg Ser Leu Asn Leu Ala Arg Val Met Asp Val Leu Tyr Arg
        515                 520                 525             
Glu Gly Asp Gly Tyr Thr Tyr Val Gly Lys Ala Ala Lys Gly Gly Ile
    530                 535                 540                 
Thr Ser Leu Leu Ile Glu Pro Ile Ala Leu
545                 550                 


<210> 405
<211> 555
<212> PRT
<213> Gossypium arboreum

<220> 
<223> (+)-delta-cadinene synthase isozyme A Acc. No.
      AAB4129

<400> 405
Met Ala Ser Gln Ala Ser Gln Val Leu Ala Ser Pro His Pro Ala Ile
 1               5                  10                  15      
Ser Ser Glu Asn Arg Pro Lys Ala Asp Phe His Pro Gly Ile Trp Gly
            20                  25                  30          
Asp Met Phe Ile Ile Cys Pro Asp Thr Asp Ile Asp Ala Ala Thr Glu
        35                  40                  45              
Leu Gln Tyr Glu Glu Leu Lys Ala Gln Val Arg Lys Met Ile Met Glu
    50                  55                  60                  
Pro Val Asp Asp Ser Asn Gln Lys Leu Pro Phe Ile Asp Ala Val Gln
65                  70                  75                  80  
Arg Leu Gly Val Ser Tyr His Phe Glu Lys Glu Ile Glu Asp Glu Leu
                85                  90                  95      
Glu Asn Ile Tyr Arg Asp Thr Asn Asn Asn Asp Ala Asp Thr Asp Leu
            100                 105                 110         
Tyr Thr Thr Ala Leu Arg Phe Arg Leu Leu Arg Glu His Gly Phe Asp
        115                 120                 125             
Ile Ser Cys Asp Ala Phe Asn Lys Phe Lys Asp Glu Ala Gly Asn Phe
    130                 135                 140                 
Lys Ala Ser Leu Thr Ser Asp Val Gln Gly Leu Leu Glu Leu Tyr Glu
145                 150                 155                 160 
Ala Ser Tyr Met Arg Val His Gly Glu Asp Ile Leu Asp Glu Ala Ile
                165                 170                 175     
Ser Phe Thr Thr Ala Gln Leu Thr Leu Ala Leu Pro Thr Leu His His
            180                 185                 190         
Pro Leu Ser Glu Gln Val Gly His Ala Leu Lys Gln Ser Ile Arg Arg
        195                 200                 205             
Gly Leu Pro Arg Val Glu Ala Arg Asn Phe Ile Ser Ile Tyr Gln Asp
    210                 215                 220                 
Leu Glu Ser His Asn Lys Ser Leu Leu Gln Phe Ala Lys Ile Asp Phe
225                 230                 235                 240 
Asn Leu Leu Gln Leu Leu His Arg Lys Glu Leu Ser Glu Ile Cys Arg
                245                 250                 255     
Trp Trp Lys Asp Leu Asp Phe Thr Arg Lys Leu Pro Phe Ala Arg Asp
            260                 265                 270         
Arg Val Val Glu Gly Tyr Phe Trp Ile Met Gly Val Tyr Phe Glu Pro
        275                 280                 285             
Gln Tyr Ser Leu Gly Arg Lys Met Leu Thr Lys Val Ile Ala Met Ala
    290                 295                 300                 
Ser Ile Val Asp Asp Thr Tyr Asp Ser Tyr Ala Thr Tyr Asp Glu Leu
305                 310                 315                 320 
Ile Pro Tyr Thr Asn Ala Ile Glu Arg Trp Asp Ile Lys Cys Met Asn
                325                 330                 335     
Gln Leu Pro Asn Tyr Met Lys Ile Ser Tyr Lys Ala Leu Leu Asn Val
            340                 345                 350         
Tyr Glu Glu Met Glu Gln Leu Leu Ala Asn Gln Gly Arg Gln Tyr Arg
        355                 360                 365             
Val Glu Tyr Ala Lys Lys Ala Met Ile Arg Leu Val Gln Ala Tyr Leu
    370                 375                 380                 
Leu Glu Ala Lys Trp Thr His Gln Asn Tyr Lys Pro Thr Phe Glu Glu
385                 390                 395                 400 
Phe Arg Asp Asn Ala Leu Pro Thr Ser Gly Tyr Ala Met Leu Ala Ile
                405                 410                 415     
Thr Ala Phe Val Gly Met Gly Glu Val Ile Thr Pro Glu Thr Phe Lys
            420                 425                 430         
Trp Ala Ala Ser Asp Pro Lys Ile Ile Lys Ala Ser Thr Ile Ile Cys
        435                 440                 445             
Arg Phe Met Asp Asp Ile Ala Glu His Lys Phe Asn His Arg Arg Glu
    450                 455                 460                 
Asp Asp Cys Ser Ala Ile Glu Cys Tyr Met Lys Gln Tyr Gly Val Thr
465                 470                 475                 480 
Ala Gln Glu Ala Tyr Asn Glu Phe Asn Lys His Ile Glu Ser Ser Trp
                485                 490                 495     
Lys Asp Val Asn Glu Glu Phe Leu Lys Pro Thr Glu Met Pro Thr Pro
            500                 505                 510         
Val Leu Cys Arg Ser Leu Asn Leu Ala Arg Val Met Asp Val Leu Tyr
        515                 520                 525             
Arg Glu Gly Asp Gly Tyr Thr His Val Gly Lys Ala Ala Lys Gly Gly
    530                 535                 540                 
Ile Thr Ser Leu Leu Ile Asp Pro Ile Gln Ile
545                 550                 555 


<210> 406
<211> 554
<212> PRT
<213> Gossypium arboreum

<220> 
<223> (+)-delta-cadinene synthase isozyme XC1 Acc. No.
      Q39761

<400> 406
Met Ala Ser Gln Val Ser Gln Met Pro Ser Ser Ser Pro Leu Ser Ser
 1               5                  10                  15      
Asn Lys Asp Glu Met Arg Pro Lys Ala Asp Phe Gln Pro Ser Ile Trp
            20                  25                  30          
Gly Asp Leu Phe Leu Asn Cys Pro Asp Lys Asn Ile Asp Ala Glu Thr
        35                  40                  45              
Glu Lys Arg His Gln Gln Leu Lys Glu Glu Val Arg Lys Met Ile Val
    50                  55                  60                  
Ala Pro Met Ala Asn Ser Thr Gln Lys Leu Ala Phe Ile Asp Ser Val
65                  70                  75                  80  
Gln Arg Leu Gly Val Ser Tyr His Phe Thr Lys Glu Ile Glu Asp Glu
                85                  90                  95      
Leu Glu Asn Ile Tyr His Asn Asn Asn Asp Ala Glu Asn Asp Leu Tyr
            100                 105                 110         
Thr Thr Ser Ile Arg Phe Arg Leu Leu Arg Glu His Gly Tyr Asn Val
        115                 120                 125             
Ser Cys Asp Val Phe Asn Lys Phe Lys Asp Glu Gln Gly Asn Phe Lys
    130                 135                 140                 
Ser Ser Val Thr Ser Asp Val Arg Gly Leu Leu Glu Leu Tyr Gln Ala
145                 150                 155                 160 
Ser Tyr Leu Arg Val His Gly Glu Asp Ile Leu Asp Glu Ala Ile Ser
                165                 170                 175     
Phe Thr Thr His His Leu Ser Leu Ala Val Ala Ser Leu Asp His Pro
            180                 185                 190         
Leu Ser Glu Glu Val Ser His Ala Leu Lys Gln Ser Ile Arg Arg Gly
        195                 200                 205             
Leu Pro Arg Val Glu Ala Arg His Tyr Leu Ser Val Tyr Gln Asp Ile
    210                 215                 220                 
Glu Ser His Asn Lys Ala Leu Leu Glu Phe Ala Lys Ile Asp Phe Asn
225                 230                 235                 240 
Met Leu Gln Phe Leu His Arg Lys Glu Leu Ser Glu Ile Cys Arg Trp
                245                 250                 255     
Trp Lys Asp Leu Asp Phe Gln Arg Lys Leu Pro Tyr Ala Arg Asp Arg
            260                 265                 270         
Val Val Glu Gly Tyr Phe Trp Ile Ser Gly Val Tyr Phe Glu Pro Gln
        275                 280                 285             
Tyr Ser Leu Gly Arg Lys Met Leu Thr Lys Val Ile Ala Met Ala Ser
    290                 295                 300                 
Ile Val Asp Asp Thr Tyr Asp Ser Tyr Ala Thr Tyr Glu Glu Leu Ile
305                 310                 315                 320 
Pro Tyr Thr Asn Ala Ile Glu Arg Trp Asp Ile Lys Cys Ile Asp Glu
                325                 330                 335     
Ile Pro Glu Tyr Met Lys Pro Ser Tyr Lys Ala Leu Leu Asp Val Tyr
            340                 345                 350         
Glu Glu Met Val Gln Leu Val Ala Glu His Gly Arg Gln Tyr Arg Val
        355                 360                 365             
Glu Tyr Ala Lys Asn Ala Met Ile Arg Leu Ala Gln Ser Tyr Leu Val
    370                 375                 380                 
Glu Ala Lys Trp Thr Leu Gln Asn Tyr Lys Pro Ser Phe Glu Glu Phe
385                 390                 395                 400 
Lys Ala Asn Ala Leu Pro Thr Cys Gly Tyr Ala Met Leu Ala Ile Thr
                405                 410                 415     
Ser Phe Val Gly Met Gly Asp Ile Val Thr Pro Glu Thr Phe Lys Trp
            420                 425                 430         
Ala Ala Ser Asp Pro Lys Ile Ile Gln Ala Ser Thr Ile Ile Cys Arg
        435                 440                 445             
Phe Met Asp Asp Val Ala Glu His Lys Phe Lys His Arg Arg Glu Asp
    450                 455                 460                 
Asp Cys Ser Ala Ile Glu Cys Tyr Met Glu Glu Tyr Gly Val Thr Ala
465                 470                 475                 480 
Gln Glu Ala Tyr Asp Val Phe Asn Lys His Val Glu Ser Ala Trp Lys
                485                 490                 495     
Asp Leu Asn Gln Glu Phe Leu Lys Pro Thr Glu Met Pro Thr Glu Val
            500                 505                 510         
Leu Asn Arg Ser Leu Asn Leu Ala Arg Val Met Asp Val Leu Tyr Arg
        515                 520                 525             
Glu Gly Asp Gly Tyr Thr Tyr Val Gly Lys Ala Ala Lys Gly Gly Ile
    530                 535                 540                 
Thr Ser Leu Leu Ile Glu Pro Ile Ala Leu
545                 550                 


<210> 407
<211> 554
<212> PRT
<213> Gossypium arboreum

<220> 
<223> (+)-delta-cadinene synthase isozyme XC14 Acc. No.
      AAA93065

<400> 407
Met Ala Ser Gln Val Ser Gln Met Pro Ser Ser Ser Pro Leu Ser Ser
 1               5                  10                  15      
Asn Lys Asp Glu Met Arg Pro Lys Ala Asp Phe Gln Pro Ser Ile Trp
            20                  25                  30          
Gly Asp Leu Phe Leu Asn Cys Pro Asp Lys Asn Ile Asp Ala Glu Thr
        35                  40                  45              
Glu Lys Arg His Gln Gln Leu Lys Glu Glu Val Arg Lys Met Ile Val
    50                  55                  60                  
Ala Pro Met Ala Asn Ser Thr Gln Lys Leu Ala Phe Ile Asp Ser Val
65                  70                  75                  80  
Gln Arg Leu Gly Val Ser Tyr His Phe Thr Lys Glu Ile Glu Asp Glu
                85                  90                  95      
Leu Glu Asn Ile Tyr His Asn Asn Asn Asp Ala Glu Asn Asp Leu Tyr
            100                 105                 110         
Thr Thr Ser Leu Arg Phe Arg Leu Leu Arg Glu His Gly Phe Asn Val
        115                 120                 125             
Ser Cys Asp Val Phe Asn Lys Phe Lys Asp Glu Gln Gly Asn Phe Lys
    130                 135                 140                 
Ser Ser Val Thr Ser Asp Val Arg Gly Leu Leu Glu Leu Tyr Gln Ala
145                 150                 155                 160 
Ser Tyr Leu Arg Val His Gly Glu Asp Ile Leu Asp Glu Ala Ile Ser
                165                 170                 175     
Phe Thr Thr Asn His Leu Ser Leu Ala Val Ala Ser Leu Asp Tyr Pro
            180                 185                 190         
Leu Ser Glu Glu Val Ser His Ala Leu Lys Gln Ser Ile Arg Arg Gly
        195                 200                 205             
Leu Pro Arg Val Glu Ala Arg His Tyr Leu Ser Val Tyr Gln Asp Ile
    210                 215                 220                 
Glu Ser His Asn Lys Val Leu Leu Glu Phe Ala Lys Ile Asp Phe Asn
225                 230                 235                 240 
Met Val Gln Leu Leu His Arg Lys Glu Leu Ser Glu Ile Ser Arg Trp
                245                 250                 255     
Trp Lys Asp Leu Asp Phe Gln Arg Lys Leu Pro Tyr Ala Arg Asp Arg
            260                 265                 270         
Val Val Glu Gly Tyr Phe Trp Ile Ser Gly Val Tyr Phe Glu Pro Gln
        275                 280                 285             
Tyr Ser Leu Gly Arg Lys Met Leu Thr Lys Val Ile Ala Met Ala Ser
    290                 295                 300                 
Ile Val Asp Asp Thr Tyr Asp Ser Tyr Ala Thr Tyr Glu Glu Leu Ile
305                 310                 315                 320 
Pro Tyr Thr Lys Ala Ile Glu Arg Trp Asp Ile Lys Cys Ile Asp Glu
                325                 330                 335     
Leu Pro Glu Tyr Met Lys Pro Ser Tyr Lys Ala Leu Leu Asp Val Tyr
            340                 345                 350         
Glu Glu Met Glu Gln Leu Val Ala Lys His Gly Arg Gln Tyr Arg Val
        355                 360                 365             
Glu Tyr Ala Lys Asn Ala Met Ile Arg Leu Ala Gln Ser Tyr Leu Val
    370                 375                 380                 
Glu Ala Arg Trp Thr Leu Gln Asn Tyr Lys Pro Ser Phe Glu Glu Phe
385                 390                 395                 400 
Lys Ala Asn Ala Leu Pro Thr Cys Gly Tyr Ala Met Leu Ala Ile Thr
                405                 410                 415     
Ser Phe Val Gly Met Gly Asp Ile Val Thr Pro Glu Thr Phe Lys Trp
            420                 425                 430         
Ala Ala Asn Asp Pro Lys Ile Ile Gln Ala Ser Thr Ile Ile Cys Arg
        435                 440                 445             
Phe Met Asp Asp Val Ala Glu His Lys Phe Lys His Arg Arg Glu Asp
    450                 455                 460                 
Asp Cys Ser Ala Ile Glu Cys Tyr Met Glu Glu Tyr Gly Val Thr Ala
465                 470                 475                 480 
Gln Glu Ala Tyr Asp Val Phe Asn Lys His Val Glu Ser Ala Trp Lys
                485                 490                 495     
Asp Val Asn Lys Glu Phe Leu Lys Pro Thr Glu Met Pro Thr Glu Val
            500                 505                 510         
Leu Asn Arg Ser Leu Asn Leu Ala Arg Val Met Asp Val Leu Tyr Arg
        515                 520                 525             
Glu Gly Asp Gly Tyr Thr Tyr Val Gly Lys Ala Ala Lys Gly Gly Ile
    530                 535                 540                 
Thr Ser Leu Leu Ile Glu Pro Val Ala Leu
545                 550                 


<210> 408
<211> 554
<212> PRT
<213> Gossypium hirsutum

<220> 
<223> (+)-delta-cadinene synthase Acc. No. AAC12784

<400> 408
Met Ala Ser Gln Val Ser Gln Met Pro Ser Ser Ser Pro Leu Ser Ser
 1               5                  10                  15      
Asn Lys Asp Glu Met Arg Pro Lys Ala Asp Phe Gln Pro Ser Ile Trp
            20                  25                  30          
Gly Asp Phe Phe Leu Asn Cys Pro Asp Lys Asn Ile Asp Ala Glu Thr
        35                  40                  45              
Gln Lys Arg His Gln Gln Leu Lys Glu Glu Val Arg Lys Met Ile Val
    50                  55                  60                  
Ala Pro Met Ala Asn Ser Thr Leu Lys Leu Ala Phe Ile Asp Ser Val
65                  70                  75                  80  
Gln Gly Leu Gly Val Ser Tyr His Phe Thr Lys Glu Ile Glu Asp Glu
                85                  90                  95      
Leu Glu Asn Ile Tyr His Asn Asn Asn Asp Ala Glu Asn Asp Leu Tyr
            100                 105                 110         
Thr Thr Ser Leu Arg Phe Arg Leu Leu Arg Glu His Gly Phe His Val
        115                 120                 125             
Ser Cys Asp Val Phe Asn Lys Phe Lys Asp Glu Gln Gly Asn Phe Lys
    130                 135                 140                 
Ser Ser Val Thr Ser Asp Val Arg Gly Leu Leu Glu Leu Tyr Gln Ala
145                 150                 155                 160 
Ser Tyr Leu Arg Val His Gly Glu Asp Ile Leu Asp Glu Ala Ile Ser
                165                 170                 175     
Phe Thr Ser Asn His Leu Ser Leu Ala Val Ala Ser Leu Asp His Pro
            180                 185                 190         
Leu Ser Glu Glu Val Ser His Ala Leu Lys Gln Ser Ile Arg Arg Gly
        195                 200                 205             
Leu Pro Arg Val Glu Ala Arg His Tyr Leu Ser Val Tyr Gln Asp Ile
    210                 215                 220                 
Glu Ser His Asn Lys Val Leu Leu Glu Phe Ala Lys Ile Asp Phe Asn
225                 230                 235                 240 
Met Val Gln Leu Leu His Arg Lys Glu Leu Ser Glu Ile Ser Arg Trp
                245                 250                 255     
Trp Lys Asp Leu Asp Phe Gln Arg Lys Leu Pro Tyr Ala Arg Asp Arg
            260                 265                 270         
Val Val Glu Gly Tyr Phe Trp Ile Ser Gly Val Tyr Phe Glu Pro Gln
        275                 280                 285             
Tyr Ser Leu Gly Arg Lys Met Leu Thr Lys Val Ile Ala Met Ala Ser
    290                 295                 300                 
Ile Val Asp Asp Thr Tyr Asp Ser Tyr Ala Thr Tyr Glu Glu Leu Ile
305                 310                 315                 320 
Pro Tyr Thr Asn Ala Ile Glu Arg Trp Asp Ile Lys Cys Ile Asp Glu
                325                 330                 335     
Leu Pro Glu Tyr Met Lys Pro Ser Tyr Lys Ala Leu Leu Asp Val Tyr
            340                 345                 350         
Glu Glu Met Glu Gln Leu Val Ala Glu His Gly Arg Gln Tyr Arg Val
        355                 360                 365             
Glu Tyr Ala Lys Asn Ala Met Ile Arg Leu Ala Gln Ser Tyr Leu Val
    370                 375                 380                 
Glu Ala Arg Trp Thr Leu Gln Asn Tyr Lys Pro Ser Phe Glu Glu Phe
385                 390                 395                 400 
Lys Ala Asn Ala Leu Pro Thr Cys Gly Tyr Ala Met Leu Ala Ile Thr
                405                 410                 415     
Ser Phe Val Gly Met Gly Asp Ile Val Thr Pro Glu Thr Phe Lys Trp
            420                 425                 430         
Ala Ala Asn Asp Pro Lys Ile Ile Gln Ala Ser Thr Ile Ile Cys Arg
        435                 440                 445             
Phe Met Asp Asp Val Thr Glu His Lys Phe Lys His Arg Arg Glu Asp
    450                 455                 460                 
Asp Cys Ser Ala Ile Glu Cys Tyr Met Glu Glu Tyr Gly Val Thr Ala
465                 470                 475                 480 
Gln Glu Ala Tyr Asp Val Phe Asn Lys His Val Glu Ser Ala Trp Lys
                485                 490                 495     
Asp Val Asn Gln Gly Phe Leu Lys Pro Thr Glu Met Pro Thr Glu Val
            500                 505                 510         
Leu Asn Arg Ser Leu Asn Leu Ala Arg Val Met Asp Val Leu Tyr Arg
        515                 520                 525             
Glu Gly Asp Gly Tyr Thr Tyr Val Gly Lys Ala Ala Lys Gly Gly Ile
    530                 535                 540                 
Thr Ser Leu Leu Ile Glu Pro Ile Ala Leu
545                 550                 


<210> 409
<211> 554
<212> PRT
<213> Gossypium hirsutum

<220> 
<223> (+)-delta-cadinene synthase Acc. No. AAX44033

<400> 409
Met Ala Ser Gln Val Ser Gln Met Pro Ser Ser Ser Pro Leu Ser Ser
 1               5                  10                  15      
Asn Lys Asp Glu Met Arg Pro Lys Ala Asp Phe Gln Pro Ser Ile Trp
            20                  25                  30          
Gly Asp Phe Phe Leu Asn Cys Pro Asp Lys Asn Ile Asp Ala Glu Thr
        35                  40                  45              
Gln Lys Arg His Gln Gln Leu Lys Glu Glu Val Arg Lys Met Ile Val
    50                  55                  60                  
Ala Pro Met Ala Asn Ser Thr Gln Lys Leu Ala Phe Ile Asp Ser Val
65                  70                  75                  80  
Gln Arg Leu Gly Val Ser Tyr His Phe Thr Lys Glu Ile Glu Asp Glu
                85                  90                  95      
Leu Glu Asn Ile Tyr His Asn Asn Asn Asp Ala Glu Asn Asp Leu Tyr
            100                 105                 110         
Thr Thr Ser Leu Arg Phe Arg Leu Leu Arg Glu His Gly Phe Asn Val
        115                 120                 125             
Ser Cys Asp Val Phe Asn Lys Phe Lys Asp Glu Gln Gly Asn Phe Lys
    130                 135                 140                 
Ser Ser Val Thr Ser Asp Val Arg Gly Leu Leu Glu Leu Tyr Gln Ala
145                 150                 155                 160 
Ser Tyr Leu Arg Val His Gly Glu Asp Ile Leu Asp Glu Ala Ile Ser
                165                 170                 175     
Phe Thr Ser Asn His Leu Ser Leu Ala Val Ala Ser Leu Asp His Pro
            180                 185                 190         
Leu Ser Glu Glu Val Ser His Ala Leu Lys Gln Ser Ile Arg Arg Gly
        195                 200                 205             
Leu Pro Arg Val Glu Ala Arg His Tyr Leu Ser Val Tyr Gln Asp Ile
    210                 215                 220                 
Glu Ser His Asn Lys Val Leu Leu Glu Phe Ala Lys Ile Asp Phe Asn
225                 230                 235                 240 
Met Val Gln Leu Leu His Arg Lys Glu Leu Ser Glu Ile Ser Arg Trp
                245                 250                 255     
Trp Lys Asp Leu Asp Phe Gln Arg Lys Leu Pro Tyr Ala Arg Asp Arg
            260                 265                 270         
Val Val Glu Gly Tyr Phe Trp Ile Ser Gly Val Tyr Phe Glu Pro Gln
        275                 280                 285             
Tyr Ser Leu Gly Arg Lys Met Leu Thr Lys Val Ile Ala Met Ala Ser
    290                 295                 300                 
Ile Val Asp Asp Thr Tyr Asp Ser Tyr Ala Thr Tyr Glu Glu Leu Ile
305                 310                 315                 320 
Pro Tyr Thr Asn Ala Ile Glu Arg Trp Asp Ile Lys Cys Ile Asp Glu
                325                 330                 335     
Leu Pro Glu Tyr Met Lys Pro Ser Tyr Lys Ala Leu Leu Asp Val Tyr
            340                 345                 350         
Glu Glu Met Glu Gln Leu Val Ala Glu His Gly Arg Gln Tyr Arg Val
        355                 360                 365             
Glu Tyr Ala Lys Asn Ala Met Ile Arg Leu Ala Gln Ser Tyr Leu Val
    370                 375                 380                 
Glu Ala Arg Trp Thr Leu Gln Asn Tyr Lys Pro Ser Phe Glu Glu Phe
385                 390                 395                 400 
Lys Ala Asn Ala Leu Pro Thr Cys Gly Tyr Ala Met Leu Ala Ile Thr
                405                 410                 415     
Ser Phe Val Gly Met Gly Asp Ile Val Thr Pro Glu Thr Phe Lys Trp
            420                 425                 430         
Ala Ala Asn Asp Pro Lys Ile Ile Gln Ala Ser Thr Ile Ile Cys Arg
        435                 440                 445             
Phe Met Asp Asp Val Ala Glu His Lys Phe Lys His Arg Arg Glu Asp
    450                 455                 460                 
Asp Cys Ser Ala Ile Glu Cys Tyr Met Glu Glu Tyr Gly Val Thr Ala
465                 470                 475                 480 
Gln Glu Ala Tyr Asp Val Phe Asn Lys His Val Glu Ser Ala Trp Lys
                485                 490                 495     
Asp Val Asn Gln Glu Phe Leu Lys Pro Thr Glu Met Pro Thr Glu Val
            500                 505                 510         
Leu Asn Arg Ser Leu Asn Leu Ala Arg Val Met Asp Val Leu Tyr Arg
        515                 520                 525             
Glu Gly Asp Gly Tyr Thr Tyr Val Gly Lys Ala Ala Lys Gly Gly Ile
    530                 535                 540                 
Thr Ser Leu Leu Ile Glu Pro Ile Ala Leu
545                 550                 


<210> 410
<211> 551
<212> PRT
<213> Gossypium hirsutum

<220> 
<223> (+)-delta-cadinene synthase Acc. No. AAF74977

<400> 410
Gln Val Ser Gln Met Pro Ser Ser Ser Pro Leu Ser Ser Asn Lys Asp
 1               5                  10                  15      
Glu Met Arg Pro Lys Ala Asp Phe Gln Pro Ser Ile Trp Gly Asp Phe
            20                  25                  30          
Phe Leu Asn Cys Pro Asp Lys Asn Ile Asp Ala Glu Thr Gln Lys Arg
        35                  40                  45              
His Gln Gln Leu Lys Glu Glu Val Arg Lys Met Ile Val Ala Pro Met
    50                  55                  60                  
Ala Asn Ser Thr Gln Lys Leu Ala Phe Ile Asp Ser Val Gln Arg Leu
65                  70                  75                  80  
Gly Val Ser Tyr His Phe Thr Lys Glu Ile Glu Asp Glu Leu Glu Asn
                85                  90                  95      
Ile Tyr His Asn Asn Asn Asp Ala Glu Asn Asp Leu Tyr Thr Thr Ser
            100                 105                 110         
Leu Arg Phe Arg Leu Leu Arg Glu His Gly Phe Asn Val Ser Cys Asp
        115                 120                 125             
Val Phe Asn Lys Phe Lys Asp Glu Gln Gly Asn Phe Lys Ser Ser Val
    130                 135                 140                 
Thr Ser Asp Val Arg Gly Leu Leu Glu Leu Tyr Gln Ala Ser Tyr Leu
145                 150                 155                 160 
Arg Val His Gly Glu Asp Ile Leu Asp Glu Ala Ile Ser Phe Thr Ser
                165                 170                 175     
Asn His Leu Ser Leu Ala Val Ala Ser Leu Asp His Pro Leu Ser Glu
            180                 185                 190         
Glu Val Ser His Ala Leu Lys Gln Ser Ile Arg Arg Gly Leu Pro Arg
        195                 200                 205             
Val Glu Ala Arg His Tyr Leu Ser Val Tyr Gln Asp Ile Glu Ser His
    210                 215                 220                 
Asn Lys Val Leu Leu Glu Phe Ala Lys Ile Asp Phe Asn Met Val Gln
225                 230                 235                 240 
Leu Leu His Arg Lys Glu Leu Ser Glu Ile Ser Arg Trp Trp Lys Asp
                245                 250                 255     
Leu Asp Phe Gln Arg Lys Leu Pro Tyr Ala Arg Asp Arg Val Val Glu
            260                 265                 270         
Gly Tyr Phe Trp Ile Ser Gly Val Tyr Phe Glu Pro Gln Tyr Ser Leu
        275                 280                 285             
Gly Arg Lys Met Leu Thr Lys Val Ile Ala Met Ala Ser Ile Val Asp
    290                 295                 300                 
Asp Thr Tyr Asp Ser Tyr Ala Thr Tyr Glu Glu Leu Ile Pro Tyr Thr
305                 310                 315                 320 
Asn Ala Ile Glu Arg Trp Asp Ile Lys Cys Ile Asp Glu Leu Pro Glu
                325                 330                 335     
Tyr Met Lys Pro Ser Tyr Lys Ala Leu Leu Asp Val Tyr Glu Glu Met
            340                 345                 350         
Glu Gln Leu Val Ala Glu His Gly Arg Gln Tyr Arg Val Glu Tyr Ala
        355                 360                 365             
Lys Asn Ala Met Ile Arg Leu Ala Gln Ser Tyr Leu Val Glu Ala Arg
    370                 375                 380                 
Trp Thr Leu Gln Asn Tyr Lys Pro Ser Phe Glu Glu Phe Lys Ala Asn
385                 390                 395                 400 
Ala Leu Pro Thr Cys Gly Tyr Ala Met Leu Ala Ile Thr Ser Phe Val
                405                 410                 415     
Gly Met Gly Asp Ile Val Thr Pro Glu Thr Phe Lys Trp Ala Ala Asn
            420                 425                 430         
Asp Pro Lys Ile Ile Gln Ala Ser Thr Ile Ile Cys Arg Phe Met Asp
        435                 440                 445             
Asp Val Ala Glu His Lys Phe Lys His Arg Arg Glu Asp Asp Cys Ser
    450                 455                 460                 
Ala Ile Glu Cys Tyr Met Glu Glu Tyr Gly Val Thr Ala Gln Glu Ala
465                 470                 475                 480 
Tyr Asp Val Phe Asn Lys His Val Glu Ser Ala Trp Lys Asp Val Asn
                485                 490                 495     
Gln Glu Phe Leu Lys Pro Thr Glu Met Pro Thr Glu Val Leu Asn Arg
            500                 505                 510         
Ser Leu Asn Leu Ala Arg Val Met Asp Val Leu Tyr Arg Glu Gly Asp
        515                 520                 525             
Gly Tyr Thr Tyr Val Gly Lys Ala Ala Lys Gly Gly Ile Thr Ser Leu
    530                 535                 540                 
Leu Ile Glu Pro Ile Ala Leu
545                 550     


<210> 411
<211> 554
<212> PRT
<213> Gossypium hirsutum

<220> 
<223> (+)-delta-cadinene synthase Acc. No. AAX44034

<400> 411
Met Ala Lys Gln Val Ser Gln Leu Leu Ser Ser Ser Pro Leu Thr Ser
 1               5                  10                  15      
Asn Lys Asp Glu Met Arg Leu Lys Ala Asp Phe Gln Pro Ser Ile Trp
            20                  25                  30          
Gly Asp Leu Phe Leu Thr Cys Leu Asp Asn Asp Ile Asp Ala Glu Thr
        35                  40                  45              
Glu Gln Arg His Gln Gln Leu Glu Gly Gly Val Arg Lys Met Ile Val
    50                  55                  60                  
Ala Pro Met Ala Asn Ser Thr Gln Lys Leu Thr Phe Ile Asp Ser Val
65                  70                  75                  80  
Gln Arg Leu Gly Val Ser Tyr Arg Phe Thr Lys Glu Ile Glu Asp Glu
                85                  90                  95      
Leu Glu Asn Ile Tyr His Asn Asn Asn Asp Ala Glu Asn Asp Leu Tyr
            100                 105                 110         
Thr Thr Ser Leu Arg Phe Arg Leu Leu Arg Glu His Gly Phe Asn Val
        115                 120                 125             
Ser Cys Glu Val Phe Asn Lys Phe Lys Asp Glu Gln Gly Asp Phe Lys
    130                 135                 140                 
Ser Ser Leu Thr Ser Asp Val Arg Gly Leu Leu Glu Leu Tyr Glu Ala
145                 150                 155                 160 
Ser Tyr Leu Arg Val His Gly Glu Asp Ile Leu Asp Glu Ala Ile Ser
                165                 170                 175     
Phe Thr Thr Asp His Leu Thr Leu Ala Val Ala Thr Leu Glu Tyr Pro
            180                 185                 190         
Leu Ser Glu His Val Ser His Ala Leu Lys Lys Ser Ile Arg Arg Gly
        195                 200                 205             
Leu Pro Arg Ile Glu Ala Arg His Tyr Leu Ser Val Tyr Gln Asp Ile
    210                 215                 220                 
Glu Ser His Asn Thr Ala Leu Leu Glu Phe Ala Lys Ile Asp Phe Asn
225                 230                 235                 240 
Met Leu Gln Leu Leu His Arg Lys Glu Leu Ser Glu Ile Cys Arg Trp
                245                 250                 255     
Trp Lys Asp Leu Asp Phe Lys Arg Lys Leu Pro Tyr Val Arg Asp Arg
            260                 265                 270         
Val Val Glu Cys Phe Phe Trp Ile Leu Gly Val Tyr Phe Glu Pro Gln
        275                 280                 285             
Tyr Ser Leu Gly Arg Lys Ile Leu Thr Lys Val Ile Ala Met Thr Ser
    290                 295                 300                 
Val Ile Asp Asp Thr Tyr Asp Ser Tyr Ala Thr Tyr Asp Glu Leu Ile
305                 310                 315                 320 
Pro Tyr Thr Asn Ala Ile Glu Arg Trp Asp Ile Lys Cys Ile Asp Gln
                325                 330                 335     
Leu Pro Glu Tyr Met Lys Leu Ser Tyr Lys Ala Leu Leu Asp Val Tyr
            340                 345                 350         
Glu Glu Met Glu Gln Leu Met Ala Glu Asp Gly Arg Gln Tyr Arg Val
        355                 360                 365             
Glu Tyr Ala Lys Asn Ile Met Ile Gln Leu Ala Gln Ala Phe Leu Met
    370                 375                 380                 
Glu Ala Lys Trp Thr Leu Gln Asn His Lys Pro Ser Phe Glu Glu Phe
385                 390                 395                 400 
Lys Ala Thr Ala Leu Gln Thr Thr Gly Tyr Ala Met Leu Ala Ile Thr
                405                 410                 415     
Ala Leu Val Asp Met Gly Asp Ile Val Thr Pro Glu Thr Phe Thr Trp
            420                 425                 430         
Ala Ala Asn Asn Pro Lys Ile Ile Gln Ala Ser Thr Ile Ile Cys Arg
        435                 440                 445             
Phe Met Asp Asp Val Ala Glu His Lys Phe Lys Gln Arg Arg Glu Asp
    450                 455                 460                 
Asp Phe Ser Gly Ile Glu Cys Tyr Met Glu Glu Tyr Gly Val Met Val
465                 470                 475                 480 
Gln Glu Ala Tyr Asn Val Phe Tyr Lys His Ile Glu Ser Ala Trp Lys
                485                 490                 495     
Asp Val Asn Lys Gly Phe Leu Lys Pro Thr Glu Met Pro Ile Glu Val
            500                 505                 510         
Leu Asn Arg Ile Leu Asn Leu Ala Arg Val Met Asn Val Leu Tyr Asn
        515                 520                 525             
Glu Gly Asp Gly Tyr Thr Tyr Val Gly Lys Ala Thr Lys Gly Ile Ile
    530                 535                 540                 
Ser Ile Leu Leu Ile Glu Pro Val Thr Leu
545                 550                 


<210> 412
<211> 559
<212> PRT
<213> Helianthus annuus

<220> 
<223> germacrene A synthase 1 Acc. No. ACA14463

<400> 412
Met Ala Ala Val Gly Ala Ser Ala Thr Pro Leu Thr Asn Thr Lys Ser
 1               5                  10                  15      
Thr Ala Glu Pro Val Arg Pro Val Ala Asn Phe Pro Pro Ser Val Trp
            20                  25                  30          
Gly Asp Leu Phe Leu Ser Phe Ser Leu Asp Lys Ser Ile Met Glu Glu
        35                  40                  45              
Tyr Ala Glu Ala Met Glu Glu Pro Lys Glu Gln Val Arg Arg Leu Ile
    50                  55                  60                  
Leu Asp Pro Thr Met Asp Ser Asn Lys Lys Leu Ser Leu Ile Tyr Thr
65                  70                  75                  80  
Val His Arg Leu Gly Leu Thr Tyr Met Phe Leu Lys Glu Ile Glu Ala
                85                  90                  95      
Gln Leu Asp Arg Leu Phe Lys Glu Phe Asn Leu Glu Asp Tyr Val Glu
            100                 105                 110         
Leu Asp Leu Tyr Thr Ile Ser Ile Asn Phe Gln Ala Phe Arg His Leu
        115                 120                 125             
Gly Tyr Lys Leu Pro Cys Asp Val Phe Asn Lys Phe Lys Asn Asp Asp
    130                 135                 140                 
Ser Thr Thr Phe Lys Glu Ser Ile Thr Gly Asp Val Arg Gly Met Leu
145                 150                 155                 160 
Gly Leu Tyr Glu Ser Ala Gln Leu Arg Leu Lys Gly Glu Asn Ile Leu
                165                 170                 175     
Asp Glu Ala Ser Ala Phe Ala Glu Thr Lys Leu Lys Ser Leu Val Asn
            180                 185                 190         
Thr Leu Glu Gly Ser Leu Ala Gln Gln Val Lys Gln Ser Leu Arg Arg
        195                 200                 205             
Pro Phe His Gln Gly Met Pro Met Val Glu Ala Arg Leu Tyr Phe Ser
    210                 215                 220                 
Asn Tyr Gln Glu Glu Cys Ser Ala His Asp Ser Ile Leu Lys Leu Ala
225                 230                 235                 240 
Lys Leu His Phe Asn Tyr Leu Gln Leu Gln Gln Lys Glu Glu Leu Arg
                245                 250                 255     
Ile Val Ser Gln Trp Trp Lys Asp Met Arg Phe Gln Glu Thr Thr Pro
            260                 265                 270         
Tyr Ile Arg Asp Arg Val Pro Glu Ile Tyr Leu Trp Ile Leu Gly Leu
        275                 280                 285             
Tyr Phe Glu Pro Arg Tyr Ser Leu Ala Arg Ile Ile Ala Thr Lys Ile
    290                 295                 300                 
Thr Leu Phe Leu Val Val Leu Asp Asp Thr Tyr Asp Ala Tyr Ala Thr
305                 310                 315                 320 
Ile Glu Glu Ile Arg Leu Leu Thr Asp Ala Ile Asn Arg Trp Asp Ile
                325                 330                 335     
Ser Ala Met Asn Gln Ile Pro Glu Tyr Ile Arg Pro Phe Tyr Lys Ile
            340                 345                 350         
Leu Leu Asp Glu Tyr Ala Glu Leu Glu Lys Gln Leu Ala Lys Glu Gly
        355                 360                 365             
Arg Ala Asn Ser Val Ile Ala Ser Lys Glu Ala Phe Gln Asp Ile Ala
    370                 375                 380                 
Arg Gly Tyr Leu Glu Glu Ala Glu Trp Thr Asn Ser Gly Tyr Val Ala
385                 390                 395                 400 
Ser Phe Pro Glu Tyr Met Lys Asn Gly Leu Ile Thr Ser Ala Tyr Asn
                405                 410                 415     
Val Ile Ser Lys Ser Ala Leu Val Gly Met Gly Glu Ile Val Ser Glu
            420                 425                 430         
Asp Ala Leu Val Trp Tyr Glu Ser His Pro Gln Ile Leu Gln Ala Ser
        435                 440                 445             
Glu Leu Ile Ser Arg Leu Gln Asp Asp Val Met Thr Tyr Gln Phe Glu
    450                 455                 460                 
Arg Glu Arg Gly Gln Ser Ala Thr Gly Val Asp Ser Tyr Ile Lys Thr
465                 470                 475                 480 
Tyr Gly Val Ser Glu Lys Val Ala Ile Asp Glu Leu Lys Lys Met Ile
                485                 490                 495     
Glu Asn Ala Trp Lys Glu Ile Asn Glu Gly Cys Leu Lys Pro Arg Glu
            500                 505                 510         
Val Ser Met Asp Leu Leu Ala Pro Ile Leu Asn Leu Ala Arg Met Ile
        515                 520                 525             
Asp Val Val Tyr Arg Tyr Asp Asp Gly Phe Thr Phe Pro Gly Lys Thr
    530                 535                 540                 
Leu Lys Glu Tyr Ile Thr Leu Leu Phe Val Gly Ser Ser Pro Met
545                 550                 555                 


<210> 413
<211> 559
<212> PRT
<213> Helianthus annuus

<220> 
<223> germacrene A synthase 2 Acc. No. ABY49939

<400> 413
Met Ala Ala Val Gly Ala Ser Ala Thr Leu Leu Thr Asn Thr Lys Ser
 1               5                  10                  15      
Ala Glu Glu Pro Val Arg Pro Val Ala Asn Phe Pro Pro Ser Val Trp
            20                  25                  30          
Gly Asp Leu Phe Leu Ser Phe Ser Leu Asp Asn Ser Met Met Glu Glu
        35                  40                  45              
Tyr Ala Glu Ala Met Glu Glu Pro Lys Gly Gln Val Arg Lys Leu Ile
    50                  55                  60                  
Leu Asp Pro Thr Met Asp Ser Asn Lys Lys Leu Ser Leu Ile Tyr Thr
65                  70                  75                  80  
Val His Arg Leu Gly Leu Thr Tyr Met Phe Phe Lys Glu Ile Glu Gly
                85                  90                  95      
Gln Leu Asp Arg Leu Phe Lys Glu Phe Asn Leu Glu Asp Tyr Val Glu
            100                 105                 110         
Val Asp Leu Tyr Thr Ile Ser Thr Asn Phe Gln Ala Phe Arg His Leu
        115                 120                 125             
Gly Tyr Lys Leu Ser Cys Asp Val Phe Asn Lys Phe Lys Asn Tyr Asp
    130                 135                 140                 
Ser Asn Thr Phe Lys Glu Ser Ile Thr Ser Asp Val Arg Gly Met Leu
145                 150                 155                 160 
Gly Leu Tyr Glu Ser Ala Gln Leu Arg Leu Lys Gly Glu Lys Ile Leu
                165                 170                 175     
Asp Glu Ala Ser Ala Phe Thr Glu Thr Lys Leu Lys Ser Leu Val Lys
            180                 185                 190         
Thr Leu Glu Gly Ser Leu Ala Gln Gln Val Lys Gln Ser Leu Lys Arg
        195                 200                 205             
Pro Phe His Gln Gly Met Pro Met Val Glu Ala Arg Leu Tyr Phe Ser
    210                 215                 220                 
Asn Tyr Gln Glu Glu Cys Ser Arg His Asp Ser Leu Leu Lys Leu Ala
225                 230                 235                 240 
Lys Leu His Phe Asn Tyr Leu Gln Leu Gln Gln Lys Glu Glu Leu Arg
                245                 250                 255     
Ile Val Ser Gln Trp Trp Lys Asp Met Arg Phe Gln Glu Thr Thr Pro
            260                 265                 270         
Tyr Ile Arg Asp Arg Val Pro Glu Ile Tyr Leu Trp Ile Leu Gly Leu
        275                 280                 285             
Tyr Phe Glu Pro Arg Tyr Ser Leu Ala Arg Ile Ile Ala Thr Lys Ile
    290                 295                 300                 
Thr Leu Phe Leu Val Val Leu Asp Asp Thr Tyr Asp Ala Tyr Ala Thr
305                 310                 315                 320 
Ile Glu Glu Val Arg Leu Leu Thr Asp Ala Ile Asn Arg Trp Asp Ile
                325                 330                 335     
Gly Ala Met Ser Gln Ile Pro Glu Tyr Ile Arg Pro Phe Tyr Lys Ile
            340                 345                 350         
Leu Leu Asp Glu Tyr Ala Glu Leu Glu Lys Gln Leu Ala Lys Glu Gly
        355                 360                 365             
Arg Ala Asn Ser Val Ile Ala Ser Lys Glu Ala Phe Gln Asp Ile Ala
    370                 375                 380                 
Arg Gly Tyr Leu Glu Glu Ala Glu Trp Thr Asn Ser Gly Tyr Val Ala
385                 390                 395                 400 
Ser Phe Pro Glu Tyr Met Lys Asn Gly Leu Ile Thr Ser Ala Tyr Asn
                405                 410                 415     
Val Ile Ser Lys Ser Ala Leu Val Gly Met Gly Glu Ile Val Ser Glu
            420                 425                 430         
Asp Ala Leu Ala Trp Tyr Glu Ser His Pro Gln Ile Leu Gln Ala Ser
        435                 440                 445             
Glu Leu Ile Ser Arg Leu Gln Asp Asp Val Met Thr Tyr Gln Phe Glu
    450                 455                 460                 
Arg Glu Arg Gly Gln Ser Ala Thr Gly Val Asp Ala Tyr Ile Lys Thr
465                 470                 475                 480 
Tyr Gly Val Ser Glu Lys Glu Ala Ile Asp Glu Leu Lys Lys Met Ile
                485                 490                 495     
Glu Asn Ala Trp Lys Glu Ile Asn Glu Gly Cys Leu Lys Pro Arg Glu
            500                 505                 510         
Val Ser Met Asp Leu Leu Ala Pro Ile Leu Asn Leu Ala Arg Met Ile
        515                 520                 525             
Asp Val Val Tyr Arg Tyr Asp Asp Gly Phe Thr Phe Pro Gly Lys Thr
    530                 535                 540                 
Leu Lys Glu Tyr Ile Thr Leu Leu Phe Val Gly Ser Ser Pro Met
545                 550                 555                 


<210> 414
<211> 557
<212> PRT
<213> Helianthus annuus

<220> 
<223> germacrene A synthase 3 Acc. No. ACZ50512

<400> 414
Met Ala Ala Val Asp Thr Asn Ala Thr Ile Gln Glu Lys Thr Thr Ala
 1               5                  10                  15      
Gly Pro Val Arg Pro Leu Ala Asn Phe Pro Pro Ser Val Trp Gly Asp
            20                  25                  30          
Arg Phe Leu Ser Phe Thr Leu Asp Asn Ser Glu Leu Glu Gly Tyr Ala
        35                  40                  45              
Lys Ala Met Glu Ala Pro Lys Glu Glu Leu Arg Arg Leu Ile Val Asp
    50                  55                  60                  
Gln Thr Met Asp Ser Asn Lys Lys Leu Ser Leu Ile Tyr Ser Val His
65                  70                  75                  80  
Arg Leu Gly Leu Thr Tyr Leu Phe Leu Gln Glu Ile Glu Ala Gln Leu
                85                  90                  95      
Asp Lys Ile Phe Lys Glu Phe Asn Leu Gln Asp Tyr Asp Glu Val Asp
            100                 105                 110         
Leu Tyr Thr Thr Ser Ile Asn Phe Gln Val Phe Arg His Leu Gly Tyr
        115                 120                 125             
Lys Leu Pro Cys Asp Val Phe Asn Lys Phe Lys Asp Asn Thr Ser Gly
    130                 135                 140                 
Ala Phe Lys Glu Asp Ile Ser Thr Asp Val Lys Gly Met Leu Gly Leu
145                 150                 155                 160 
Tyr Glu Ser Ser Gln Leu Arg Thr Arg Gly Glu Ser Ile Leu Asp Glu
                165                 170                 175     
Ala Ser Ser Phe Thr Glu Thr Lys Leu Lys Ser Val Val Asn Asn Leu
            180                 185                 190         
Glu Gly Asn Leu Ala Gln Gln Val Leu Gln Ser Leu Arg Arg Pro Phe
        195                 200                 205             
His Gln Gly Met Pro Met Val Glu Ala Arg Leu Tyr Phe Ser Asn Tyr
    210                 215                 220                 
Ser Glu Glu Cys Ala Thr His Glu Cys Leu Leu Lys Leu Ala Lys Leu
225                 230                 235                 240 
His Phe Ser Tyr Leu Glu Leu Gln Gln Lys Glu Glu Leu Arg Ile Val
                245                 250                 255     
Ser Lys Trp Trp Lys Asp Met Arg Phe Gln Glu Thr Thr Pro Tyr Ile
            260                 265                 270         
Arg Asp Arg Val Pro Glu Ile Tyr Leu Trp Ile Leu Gly Leu Tyr Phe
        275                 280                 285             
Glu Pro Arg Tyr Ser Leu Ala Arg Ile Ile Ala Thr Lys Ile Thr Leu
    290                 295                 300                 
Phe Leu Val Val Leu Asp Asp Thr Tyr Asp Ala Tyr Ala Thr Ile Glu
305                 310                 315                 320 
Glu Ile Arg Leu Leu Thr Asp Ala Ile Asn Arg Trp Asp Met Ser Ala
                325                 330                 335     
Met Glu Gln Ile Pro Glu Tyr Ile Arg Pro Phe Tyr Lys Ile Leu Leu
            340                 345                 350         
Asp Glu Tyr Ala Glu Leu Glu Lys Gln Leu Ala Ile Glu Gly Arg Ala
        355                 360                 365             
Lys Ser Val Ile Ala Ser Lys Glu Ala Phe Gln Asp Ile Ala Arg Gly
    370                 375                 380                 
Tyr Leu Glu Glu Ala Glu Trp Thr Asn Ser Gly Tyr Val Ala Ser Phe
385                 390                 395                 400 
Pro Glu Tyr Met Lys Asn Gly Leu Ile Thr Ser Ala Tyr Asn Val Ile
                405                 410                 415     
Ser Lys Ser Ala Leu Val Gly Met Gly Asp Ile Val Ser Glu Asn Ala
            420                 425                 430         
Leu Ala Trp Tyr Glu Ser His Pro Lys Thr Leu Gln Ala Ser Glu Leu
        435                 440                 445             
Ile Ser Arg Leu Gln Asp Asp Val Met Thr Tyr Gln Ser Glu Arg Glu
    450                 455                 460                 
Arg Gly Gln Ser Ala Thr Gly Val Asp Ala Tyr Ile Lys Thr Tyr Gly
465                 470                 475                 480 
Val Ser Glu Lys Glu Ala Ile Asp Glu Leu Lys Ile Met Ile Glu Asn
                485                 490                 495     
Ala Trp Lys Asp Ile Asn Glu Gly Cys Leu Lys Pro Arg Glu Val Ser
            500                 505                 510         
Met Asp Leu Leu Ala Pro Ile Leu Asn Leu Ala Arg Met Ile Asp Val
        515                 520                 525             
Val Tyr Arg Tyr Asp Asp Gly Phe Thr Phe Pro Gly Lys Thr Met Lys
    530                 535                 540                 
Glu Tyr Ile Thr Leu Leu Phe Val Gly Ser Val Ser Met
545                 550                 555         


<210> 415
<211> 555
<212> PRT
<213> Helianthus annuus

<220> 
<223> gamma-cadinene synthase Acc. No. AAY41422

<400> 415
Met Ala Thr Thr Glu Ala Asn Thr Met Ala Gln Ala Asn Ser Gln Thr
 1               5                  10                  15      
Thr Ile Glu Pro Val Arg His Leu Ala Asn Phe Pro Pro Ser Ile Trp
            20                  25                  30          
Gly Asp Gln Phe Leu Ser Phe Ser Leu Asp Asn Ser Gln Leu Glu Ala
        35                  40                  45              
Tyr Ser Lys Ala Met Glu Gln Pro Lys Glu Asn Val Arg Arg Met Ile
    50                  55                  60                  
Leu Asn Pro Ala Ile Asp Thr Asn Glu Lys Leu Gly Leu Ile Tyr Cys
65                  70                  75                  80  
Val Tyr Arg Leu Gly Leu Thr Tyr Asn Phe Ser Lys Asp Ile Asp Gly
                85                  90                  95      
Gln Leu Asp Glu Leu Phe Lys Gln Leu Asn Leu Gln Ser Tyr Asn Glu
            100                 105                 110         
Ala Asp Leu Tyr Thr Ile Ser Ile His Phe Gln Val Phe Arg His Phe
        115                 120                 125             
Gly Tyr Arg Phe Ser Cys Asp Val Phe Asn Lys Phe Lys Asp Ser Ser
    130                 135                 140                 
Ser Gly Lys Phe Lys Glu Asp Met Thr Arg Asp Val Arg Gly Met Ile
145                 150                 155                 160 
Ser Leu Tyr Glu Ser Ala Gln Leu Arg Ile Arg Gly Glu Ser Ile Leu
                165                 170                 175     
Asp Glu Ala Gly Ala Phe Ala Glu Ser Lys Leu Lys Thr Ile Glu Lys
            180                 185                 190         
Thr Leu Asp Gly Thr Leu Ala Gln Gln Val Lys His Val Leu Glu Arg
        195                 200                 205             
Pro Phe Asn Arg Gly His Gln Met Val Glu Ala Arg Lys Tyr Leu Phe
    210                 215                 220                 
Leu Phe Glu Glu Glu Ile Ser Arg Tyr Asp Ser Leu Leu Met Leu Ala
225                 230                 235                 240 
Lys Val His Phe Asn Tyr Leu Gln Leu Leu Gln Lys Glu Glu Leu Arg
                245                 250                 255     
Ser Val Ser Lys Trp Trp Lys Asp Leu Asp Leu Pro Ala Lys Thr Leu
            260                 265                 270         
Tyr Val Arg Asp Arg Val Pro Glu Leu Tyr Val Trp Ile Leu Ala Phe
        275                 280                 285             
Phe Leu Glu Pro Tyr Tyr Ser Glu Val Arg Ile Ile Thr Thr Lys Ile
    290                 295                 300                 
Val Leu Leu Val Leu Val Leu Asp Asp Thr Tyr Asp Ala Tyr Ala Thr
305                 310                 315                 320 
Ile Glu Glu Ser Arg Leu Leu Thr His Ala Ile Asn Arg Trp Glu Val
                325                 330                 335     
Ser Ala Met Leu Gln Leu Pro Glu Tyr Met Lys Pro Leu Tyr Glu Ile
            340                 345                 350         
Leu Leu Asn Glu Tyr Asp Gly Phe Tyr Lys His Gly Arg Thr Asn Val
        355                 360                 365             
Ile Glu Thr Ser Lys Lys Ala Phe Gln Asp Leu Ala Arg Ser Tyr His
    370                 375                 380                 
Gln Glu Ser Glu Trp Arg His Ala Lys Glu Val Pro Ser Phe Glu Glu
385                 390                 395                 400 
Tyr Met Lys Ile Gly Thr Thr Thr Ser Ala His Asn Val Leu Ser Lys
                405                 410                 415     
Thr Ala Leu Ile Gly Met Gly Asn Ile Val Thr Arg Glu Ala Leu Ala
            420                 425                 430         
Trp Tyr Glu Ser Tyr Pro Lys Ile Val Gln Leu Ser Glu Leu Ile Gly
        435                 440                 445             
Arg Leu Glu Asp Asp Val Val Ser Val Glu Phe Glu Arg Glu Arg Ala
    450                 455                 460                 
Pro Thr Ala Thr Ser Val Asp Ala Tyr Met Lys Thr Tyr Gly Val Ser
465                 470                 475                 480 
Glu Asn Val Ala Val Lys Ile Leu Lys Lys Leu Val Glu Asn Gly Trp
                485                 490                 495     
Lys Asp Leu Asn Glu Ala Cys Leu Lys Pro Thr Glu Val Ser Leu Asp
            500                 505                 510         
Leu Leu Ala Pro Ile Ile Gly Leu Thr Asn Met Thr Asp Val Ala Tyr
        515                 520                 525             
Arg His Asn Asp Gly Leu Thr Phe Pro Glu Lys Thr Leu Lys Glu Tyr
    530                 535                 540                 
Ile Thr Leu Leu Phe Cys Val Pro Val Pro Met
545                 550                 555 


<210> 416
<211> 350
<212> PRT
<213> Hyoscyamus muticus

<220> 
<223> vetispiradiene synthase Acc. No. AAA86339

<400> 416
Leu His Lys Ser Ile Pro Arg Val Glu Thr Arg Tyr Phe Ile Thr Ile
 1               5                  10                  15      
Tyr Glu Glu Glu Glu Leu Lys Asn Asp Val Leu Leu Arg Phe Ala Lys
            20                  25                  30          
Leu Asp Phe Asn Leu Leu Gln Met Leu His Lys Gln Glu Leu Thr Glu
        35                  40                  45              
Val Ser Met Trp Trp Lys Asp Leu Asp Phe Val Thr Thr Leu Pro Tyr
    50                  55                  60                  
Ala Arg Asp Arg Ala Val Glu Cys Tyr Phe Trp Thr Val Gly Val Tyr
65                  70                  75                  80  
Ala Glu Pro Gln Tyr Ser Glu Ala Arg Val Met Leu Ala Lys Thr Ile
                85                  90                  95      
Ala Met Ile Ser Ile Val Asp Asp Thr Phe Asp Ala Tyr Gly Ile Val
            100                 105                 110         
Lys Glu Leu Glu Val Tyr Thr Asp Ala Ile Gln Arg Trp Asp Ile Asn
        115                 120                 125             
Gln Ile Asp Arg Leu Pro Asp Tyr Met Lys Ile Ser Tyr Lys Val Leu
    130                 135                 140                 
Leu Asp Leu Tyr Lys Asp Tyr Glu Thr Glu Leu Ser Lys Asp Gly Arg
145                 150                 155                 160 
Ser Glu Val Val His Tyr Ala Lys Glu Arg Met Lys Glu Ile Val Arg
                165                 170                 175     
Asn Tyr Phe Val Glu Ala Lys Trp Phe Ile Glu Gly Tyr Met Pro Pro
            180                 185                 190         
Val Ser Glu Tyr Leu Asn Asn Arg Leu Ala Thr Ser Thr Tyr Tyr Leu
        195                 200                 205             
Leu Thr Thr Thr Ser Tyr Leu Gly Met Lys Cys Ala Asn Lys Glu Asp
    210                 215                 220                 
Phe Glu Trp Leu Thr Lys Asn Pro Lys Ile Leu Glu Ala Asn Val Thr
225                 230                 235                 240 
Leu Cys Arg Val Ile Asp Asp Ile Ala Thr Tyr Glu Val Glu Lys Gly
                245                 250                 255     
Arg Gly Gln Ile Ala Thr Gly Ile Glu Cys Tyr Met Arg Asp Tyr Gly
            260                 265                 270         
Val Ser Thr Glu Glu Ala Met Glu Lys Phe Gln Glu Met Ala Glu Ile
        275                 280                 285             
Ala Trp Lys Asp Val Asn Glu Gly Ile Leu Arg Pro Thr Pro Val Ser
    290                 295                 300                 
Ala Lys Ile Leu Thr Arg Ile Leu Asn Leu Ala Arg Ile Ile Asp Val
305                 310                 315                 320 
Thr Tyr Leu His Asn Gln Asp Gly Tyr Thr His Pro Glu Lys Val Leu
                325                 330                 335     
Lys Pro His Ile Ile Ala Leu Val Val Asp Ser Ile Glu Ile
            340                 345                 350 


<210> 417
<211> 311
<212> PRT
<213> Kitasatospora griseola

<220> 
<223> diterpene cyclase-2 Acc. No. BAB39207

<400> 417
Met Pro Asp Ala Ile Glu Phe Glu His Glu Gly Arg Arg Asn Pro Asn
 1               5                  10                  15      
Ser Ala Glu Ala Glu Ser Ala Tyr Ser Ser Ile Ile Ala Ala Leu Asp
            20                  25                  30          
Leu Gln Glu Ser Asp Tyr Ala Val Ile Ser Gly His Ser Arg Ile Val
        35                  40                  45              
Gly Ala Ala Ala Leu Val Tyr Pro Asp Ala Asp Ala Glu Thr Leu Leu
    50                  55                  60                  
Ala Ala Ser Leu Trp Thr Ala Cys Leu Ile Val Asn Asp Asp Arg Trp
65                  70                  75                  80  
Asp Tyr Val Gln Glu Asp Gly Gly Arg Leu Ala Pro Gly Glu Trp Phe
                85                  90                  95      
Asp Gly Val Thr Glu Val Val Asp Thr Trp Arg Thr Ala Gly Pro Arg
            100                 105                 110         
Leu Pro Asp Pro Phe Phe Glu Leu Val Arg Thr Thr Met Ser Arg Leu
        115                 120                 125             
Asp Ala Ala Leu Gly Ala Glu Ala Ala Asp Glu Ile Gly His Glu Ile
    130                 135                 140                 
Lys Arg Ala Ile Thr Ala Met Lys Trp Glu Gly Val Trp Asn Glu Tyr
145                 150                 155                 160 
Thr Lys Lys Thr Ser Leu Ala Thr Tyr Leu Ser Phe Arg Arg Gly Tyr
                165                 170                 175     
Cys Thr Met Asp Val Gln Val Val Leu Asp Lys Trp Ile Asn Gly Gly
            180                 185                 190         
Arg Ser Phe Ala Ala Leu Arg Asp Asp Pro Val Arg Arg Ala Ile Asp
        195                 200                 205             
Asp Val Val Val Arg Phe Gly Cys Leu Ser Asn Asp Tyr Tyr Ser Trp
    210                 215                 220                 
Gly Arg Glu Lys Lys Ala Val Asp Lys Ser Asn Ala Val Arg Ile Leu
225                 230                 235                 240 
Met Asp His Ala Gly Tyr Asp Glu Ser Thr Ala Leu Ala His Val Arg
                245                 250                 255     
Asp Asp Cys Val Gln Ala Ile Thr Asp Leu Asp Cys Ile Glu Glu Ser
            260                 265                 270         
Ile Lys Arg Ser Gly His Leu Gly Ser His Ala Gln Glu Leu Leu Asp
        275                 280                 285             
Tyr Leu Ala Cys His Arg Pro Leu Ile Tyr Ala Ala Ala Thr Trp Pro
    290                 295                 300                 
Thr Glu Thr Asn Arg Tyr Arg
305                 310     


<210> 418
<211> 566
<212> PRT
<213> Antirrhinum majus

<220> 
<223> (3S)-(E)-nerolidol synthase Acc. No. ABR24417

<400> 418
Met Ser Asn Leu His Val Lys Lys Thr Asp Arg Ile Ala Ser Gly Phe
 1               5                  10                  15      
Asp Val Ala Tyr Leu Ser Ala Ala Asn Lys Thr His Gln Trp Ser Ile
            20                  25                  30          
Ala Asp Asp Ile Ala Ser Thr Pro Gly Ser Pro Arg Leu His Tyr Pro
        35                  40                  45              
Met Asp Phe Asn Gly Gln Ser Thr Arg Thr Pro Asp Asn Phe Ser Met
    50                  55                  60                  
Glu Tyr Asp Lys Lys Ile Glu Glu Ile Lys Asn Leu Leu Arg Ser Lys
65                  70                  75                  80  
Arg Glu Glu Glu Pro Ile Asp Arg Leu Met Phe Val Asp Ala Ile Gln
                85                  90                  95      
Arg Leu Gly Val Asn His Asn Phe Glu Glu Leu Ile Glu Thr Ile Leu
            100                 105                 110         
Arg Asn Tyr Tyr Glu Ser Thr Ser Ala Asn Ile Cys Gly Phe His Thr
        115                 120                 125             
Leu His Asp Val Ser Leu Phe Phe Arg Leu Met Arg Gln His Gly Tyr
    130                 135                 140                 
Asp Ile Ser Ser Asp Val Phe Asn Lys Phe Lys Gly Asp Asp Gly Arg
145                 150                 155                 160 
Phe Arg Gly Glu Leu Gln Arg Asp Thr Arg Gly Leu Met Glu Leu Tyr
                165                 170                 175     
Glu Ala Ser Gln Leu Arg Phe Glu Gly Glu Tyr Thr Leu Asp Glu Ala
            180                 185                 190         
Glu Ser Phe Ser Ser Gln Asn Leu Asn Lys Tyr Leu Ala Asp Met Asp
        195                 200                 205             
Cys Ser Ser Cys Arg Leu Val Thr Asn Lys Leu Gln His Pro Tyr Arg
    210                 215                 220                 
Lys Ser Ile Gly Arg Leu Thr Thr Arg Tyr Asp Phe Arg Gly Lys Asn
225                 230                 235                 240 
Gln Trp Gly Lys Thr Leu His Glu Leu Ala Ala Met Asp Leu Arg Met
                245                 250                 255     
Arg Lys Ser Glu Tyr Gln Lys Glu Leu Phe Gln Val Ser Glu Trp Trp
            260                 265                 270         
Lys Glu Leu Arg Ile Ala Glu Asn Leu Ser Leu Ala Arg Asn Gln Pro
        275                 280                 285             
Leu Lys Trp Tyr Thr Cys Ser Met Ala Ile Leu Ile Asp Asp Ile Thr
    290                 295                 300                 
Leu Ser Glu Gln Arg Ile Glu Leu Thr Lys Ser Ile Thr Phe Ile Tyr
305                 310                 315                 320 
Leu Ile Asp Asp Ile Phe Asp Val Tyr Gly Ser Pro Glu Glu Leu Val
                325                 330                 335     
Ile Phe Ala Glu Ala Val Ser Lys Trp Asp Tyr Ala Ala Val Glu Thr
            340                 345                 350         
Leu Pro Asp Tyr Met Lys Leu Cys Tyr Lys Ser Leu Leu Asp Thr Thr
        355                 360                 365             
Asn Glu Ile Gly Tyr Lys Ile Tyr Glu Lys Tyr Gly Tyr Asn Pro Ile
    370                 375                 380                 
Asp Ser Leu Lys Thr Thr Trp Ala Ser Leu Cys Asn Ala Phe Leu Glu
385                 390                 395                 400 
Glu Ala Lys Trp Phe Ala Ser Gly Asn Leu Pro Asn Ala Thr Lys Tyr
                405                 410                 415     
Leu Glu Asn Gly Lys Val Ser Ser Gly Val Tyr Val Val Met Val His
            420                 425                 430         
Leu Phe Phe Leu Leu Gly Leu Gly Gly Thr Cys Gly Ser Ala Ile His
        435                 440                 445             
Leu Asn Asp Thr Ser Lys Leu Met Ser Ser Val Ala Thr Ile Leu Arg
    450                 455                 460                 
Leu Trp Asp Asp Leu Gly Ser Ala Lys Asp Glu His Gln Asp Gly Lys
465                 470                 475                 480 
Asp Gly Ser Tyr Ile Glu Cys Tyr Met Lys Glu His Ile Ser Leu Ser
                485                 490                 495     
Thr Glu Gln Ala Gln Gln His Ala Ile Asp Leu Ile Ser Ser Glu Trp
            500                 505                 510         
Lys Leu Leu Asn Lys Glu Cys Phe Asn Leu Asn His Val Ser Thr Ser
        515                 520                 525             
Ser Ile Lys Lys Ala Ala Leu Asn Thr Ala Arg Met Val Pro Leu Met
    530                 535                 540                 
Tyr Ser Tyr Asp Glu Asn Gln Gly Leu Pro Ile Leu Glu Glu Tyr Val
545                 550                 555                 560 
Lys Ile Met Leu Phe Asp
                565     


<210> 419
<211> 547
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> (-)-E-beta-caryophyllene synthase Acc. No.
      AAO85539

<400> 419
Met Gly Ser Glu Val Asn Arg Pro Leu Ala Asp Phe Pro Ala Asn Ile
 1               5                  10                  15      
Trp Glu Asp Pro Leu Thr Ser Phe Ser Lys Ser Asp Leu Gly Thr Glu
            20                  25                  30          
Thr Phe Lys Glu Lys His Ser Thr Leu Lys Glu Ala Val Lys Glu Ala
        35                  40                  45              
Phe Met Ser Ser Lys Ala Asn Pro Ile Glu Asn Ile Lys Phe Ile Asp
    50                  55                  60                  
Ala Leu Cys Arg Leu Gly Val Ser Cys His Phe Glu Lys Asp Ile Val
65                  70                  75                  80  
Glu Gln Leu Asp Lys Ser Phe Asp Cys Leu Asp Phe Pro Gln Met Val
                85                  90                  95      
Arg Gln Glu Gly Cys Asp Leu Tyr Thr Val Gly Ile Ile Phe Gln Val
            100                 105                 110         
Phe Arg Gln Phe Gly Phe Lys Leu Ser Ala Asp Val Phe Glu Lys Phe
        115                 120                 125             
Lys Asp Glu Asn Gly Lys Phe Lys Gly His Leu Val Thr Asp Ala Tyr
    130                 135                 140                 
Gly Met Leu Ser Leu Tyr Glu Ala Ala Gln Trp Gly Thr His Gly Glu
145                 150                 155                 160 
Asp Ile Ile Asp Glu Ala Leu Ala Phe Ser Arg Ser His Leu Glu Glu
                165                 170                 175     
Ile Ser Ser Arg Ser Ser Pro His Leu Ala Ile Arg Ile Lys Asn Ala
            180                 185                 190         
Leu Lys His Pro Tyr His Lys Gly Ile Ser Arg Ile Glu Thr Arg Gln
        195                 200                 205             
Tyr Ile Ser Tyr Tyr Glu Glu Glu Glu Ser Cys Asp Pro Thr Leu Leu
    210                 215                 220                 
Glu Phe Ala Lys Ile Asp Phe Asn Leu Leu Gln Ile Leu His Arg Glu
225                 230                 235                 240 
Glu Leu Ala Cys Val Thr Arg Trp His His Glu Met Glu Phe Lys Ser
                245                 250                 255     
Lys Val Thr Tyr Thr Arg His Arg Ile Thr Glu Ala Tyr Leu Trp Ser
            260                 265                 270         
Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ser Gln Ala Arg Val Ile Thr
        275                 280                 285             
Thr Met Ala Leu Ile Leu Phe Thr Ala Leu Asp Asp Met Tyr Asp Ala
    290                 295                 300                 
Tyr Gly Thr Met Glu Glu Leu Glu Leu Phe Thr Asp Ala Met Asp Glu
305                 310                 315                 320 
Trp Leu Pro Val Val Pro Asp Glu Ile Pro Ile Pro Asp Ser Met Lys
                325                 330                 335     
Phe Ile Tyr Asn Val Thr Val Glu Phe Tyr Asp Lys Leu Asp Glu Glu
            340                 345                 350         
Leu Glu Lys Glu Gly Arg Ser Gly Cys Gly Phe His Leu Lys Lys Ser
        355                 360                 365             
Leu Gln Lys Thr Ala Asn Gly Tyr Met Gln Glu Ala Lys Trp Leu Lys
    370                 375                 380                 
Lys Asp Tyr Ile Ala Thr Phe Asp Glu Tyr Lys Glu Asn Ala Ile Leu
385                 390                 395                 400 
Ser Ser Gly Tyr Tyr Gly Leu Ile Ala Met Thr Phe Val Arg Met Thr
                405                 410                 415     
Asp Val Ala Lys Leu Asp Ala Phe Glu Trp Leu Asn Ser His Pro Lys
            420                 425                 430         
Ile Arg Val Ala Ser Glu Ile Ile Ser Arg Phe Thr Asp Asp Ile Ser
        435                 440                 445             
Ser Tyr Glu Phe Glu His Lys Arg Glu His Val Ala Thr Gly Ile Asp
    450                 455                 460                 
Cys Tyr Met Gln Gln Phe Gly Val Ser Lys Glu Arg Ala Val Glu Val
465                 470                 475                 480 
Met Gly Asn Ile Val Ser Asp Ala Trp Lys Asp Leu Asn Gln Glu Leu
                485                 490                 495     
Met Arg Pro His Val Phe Pro Phe Pro Leu Leu Met Arg Val Leu Asn
            500                 505                 510         
Leu Ser Arg Val Ile Asp Val Phe Tyr Arg Tyr Gln Asp Ala Tyr Thr
        515                 520                 525             
Asn Pro Lys Leu Leu Lys Glu His Ile Val Ser Leu Leu Ile Glu Thr
    530                 535                 540                 
Ile Pro Ile
545         


<210> 420
<211> 524
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> (Z)-gamma-bisabolene synthase Acc. No. NP_193064

<400> 420
Met Glu Ser Gln Thr Thr Phe Lys Tyr Glu Ser Leu Ala Phe Thr Lys
 1               5                  10                  15      
Leu Ser His Cys Gln Trp Thr Asp Tyr Phe Leu Ser Val Pro Ile Asp
            20                  25                  30          
Glu Ser Glu Leu Asp Val Ile Thr Arg Glu Ile Asp Ile Leu Lys Pro
        35                  40                  45              
Glu Val Met Glu Leu Leu Ser Ser Gln Gly Asp Asp Glu Thr Ser Lys
    50                  55                  60                  
Arg Lys Val Leu Leu Ile Gln Leu Leu Leu Ser Leu Gly Leu Ala Phe
65                  70                  75                  80  
His Phe Glu Asn Glu Ile Lys Asn Ile Leu Glu His Ala Phe Arg Lys
                85                  90                  95      
Ile Asp Asp Ile Thr Gly Asp Glu Lys Asp Leu Ser Thr Ile Ser Ile
            100                 105                 110         
Met Phe Arg Val Phe Arg Thr Tyr Gly His Asn Leu Pro Ser Ser Val
        115                 120                 125             
Phe Lys Arg Phe Thr Gly Asp Asp Gly Lys Phe Gln Gln Ser Leu Thr
    130                 135                 140                 
Glu Asp Ala Lys Gly Ile Leu Ser Leu Tyr Glu Ala Ala His Leu Gly
145                 150                 155                 160 
Thr Thr Thr Asp Tyr Ile Leu Asp Glu Ala Leu Lys Phe Thr Ser Ser
                165                 170                 175     
His Leu Lys Ser Leu Leu Ala Gly Gly Thr Cys Arg Pro His Ile Leu
            180                 185                 190         
Arg Leu Ile Arg Asn Thr Leu Tyr Leu Pro Gln Arg Trp Asn Met Glu
        195                 200                 205             
Ala Val Ile Ala Arg Glu Tyr Ile Ser Phe Tyr Glu Gln Glu Glu Asp
    210                 215                 220                 
His Asp Lys Met Leu Leu Arg Leu Ala Lys Leu Asn Phe Lys Leu Leu
225                 230                 235                 240 
Gln Leu His Tyr Ile Lys Glu Leu Lys Ser Phe Ile Lys Trp Trp Met
                245                 250                 255     
Glu Leu Gly Leu Thr Ser Lys Trp Pro Ser Gln Phe Arg Glu Arg Ile
            260                 265                 270         
Val Glu Ala Trp Leu Ala Gly Leu Met Met Tyr Phe Glu Pro Gln Phe
        275                 280                 285             
Ser Gly Gly Arg Val Ile Ala Ala Lys Phe Asn Tyr Leu Leu Thr Ile
    290                 295                 300                 
Leu Asp Asp Ala Cys Asp His Tyr Phe Ser Ile His Glu Leu Thr Arg
305                 310                 315                 320 
Leu Val Ala Cys Val Glu Arg Trp Ser Pro Asp Gly Ile Asp Thr Leu
                325                 330                 335     
Glu Asp Ile Ser Arg Ser Val Phe Lys Leu Met Leu Asp Val Phe Asp
            340                 345                 350         
Asp Ile Gly Lys Gly Val Arg Ser Glu Gly Ser Ser Tyr His Leu Lys
        355                 360                 365             
Glu Met Leu Glu Glu Leu Asn Thr Leu Val Arg Ala Asn Leu Asp Leu
    370                 375                 380                 
Val Lys Trp Ala Arg Gly Ile Gln Thr Ala Gly Lys Glu Ala Tyr Glu
385                 390                 395                 400 
Trp Val Arg Ser Arg Pro Arg Leu Ile Lys Ser Leu Ala Ala Lys Gly
                405                 410                 415     
Arg Leu Met Asp Asp Ile Thr Asp Phe Asp Ser Asp Met Ser Asn Gly
            420                 425                 430         
Phe Ala Ala Asn Ala Ile Asn Tyr Tyr Met Lys Gln Phe Val Val Thr
        435                 440                 445             
Lys Glu Glu Ala Ile Leu Glu Cys Gln Arg Met Ile Val Asp Ile Asn
    450                 455                 460                 
Lys Thr Ile Asn Glu Glu Leu Leu Lys Thr Thr Ser Val Pro Gly Arg
465                 470                 475                 480 
Val Leu Lys Gln Ala Leu Asn Phe Gly Arg Leu Leu Glu Leu Leu Tyr
                485                 490                 495     
Thr Lys Ser Asp Asp Ile Tyr Asn Cys Ser Glu Gly Lys Leu Lys Glu
            500                 505                 510         
Tyr Ile Val Thr Leu Leu Ile Asp Pro Ile Arg Leu
        515                 520                 


<210> 421
<211> 554
<212> PRT
<213> Arabidopsis thaliana

<220> 
<223> (Z)-gamma-bisabolene synthase Acc. No. NP_193066

<400> 421
Met Glu Ser Gln Thr Lys Phe Asp Tyr Glu Ser Leu Ala Phe Thr Lys
 1               5                  10                  15      
Leu Ser His Ser Gln Trp Thr Asp Tyr Phe Leu Ser Val Pro Ile Asp
            20                  25                  30          
Asp Ser Glu Leu Asp Ala Ile Thr Arg Glu Ile Asp Ile Ile Lys Pro
        35                  40                  45              
Glu Val Arg Lys Leu Leu Ser Ser Lys Gly Asp Asp Glu Thr Ser Lys
    50                  55                  60                  
Arg Lys Val Leu Leu Ile Gln Ser Leu Leu Ser Leu Gly Leu Ala Phe
65                  70                  75                  80  
His Phe Glu Asn Glu Ile Lys Asp Ile Leu Glu Asp Ala Phe Arg Arg
                85                  90                  95      
Ile Asp Asp Ile Thr Gly Asp Glu Asn Asp Leu Ser Thr Ile Ser Ile
            100                 105                 110         
Met Phe Arg Val Phe Arg Thr Tyr Gly His Asn Leu Pro Ser Ser Val
        115                 120                 125             
Phe Lys Arg Phe Thr Gly Asp Asp Gly Lys Phe Glu Arg Ser Leu Thr
    130                 135                 140                 
Glu Asp Ala Lys Gly Ile Leu Ser Leu Tyr Glu Ala Ala His Leu Gly
145                 150                 155                 160 
Thr Thr Thr Asp Tyr Ile Leu Asp Glu Ala Leu Glu Phe Thr Ser Ser
                165                 170                 175     
His Leu Lys Ser Leu Leu Val Gly Gly Met Cys Arg Pro His Ile Leu
            180                 185                 190         
Arg Leu Ile Arg Asn Thr Leu Tyr Leu Pro Gln Arg Trp Asn Met Glu
        195                 200                 205             
Ala Val Ile Ala Arg Glu Tyr Ile Ser Phe Tyr Glu Gln Glu Glu Asp
    210                 215                 220                 
His Asp Lys Met Leu Leu Arg Leu Ala Lys Leu Asn Phe Lys Leu Leu
225                 230                 235                 240 
Gln Leu His Tyr Ile Lys Glu Leu Lys Thr Phe Ile Lys Trp Trp Met
                245                 250                 255     
Glu Leu Gly Leu Thr Ser Lys Trp Pro Ser Gln Phe Arg Glu Arg Ile
            260                 265                 270         
Val Glu Ala Trp Leu Ala Gly Leu Met Met Tyr Phe Glu Pro Gln Phe
        275                 280                 285             
Ser Gly Gly Arg Val Ile Ala Ala Lys Phe Asn Tyr Leu Leu Thr Ile
    290                 295                 300                 
Leu Asp Asp Ala Cys Asp His Tyr Phe Ser Ile Pro Glu Leu Thr Arg
305                 310                 315                 320 
Leu Val Asp Cys Val Glu Arg Trp Asn His Asp Gly Ile His Thr Leu
                325                 330                 335     
Glu Asp Ile Ser Arg Ile Ile Phe Lys Leu Ala Leu Asp Val Phe Asp
            340                 345                 350         
Asp Ile Gly Arg Gly Val Arg Ser Lys Gly Cys Ser Tyr Tyr Leu Lys
        355                 360                 365             
Glu Met Leu Glu Glu Leu Lys Ile Leu Val Arg Ala Asn Leu Asp Leu
    370                 375                 380                 
Val Lys Trp Ala Arg Gly Asn Gln Leu Pro Ser Phe Glu Glu His Val
385                 390                 395                 400 
Glu Val Gly Gly Ile Ala Leu Thr Thr Tyr Ala Thr Leu Met Tyr Ser
                405                 410                 415     
Phe Val Gly Met Gly Glu Ala Val Gly Lys Glu Ala Tyr Glu Trp Val
            420                 425                 430         
Arg Ser Arg Pro Arg Leu Ile Lys Ser Leu Ala Ala Lys Gly Arg Leu
        435                 440                 445             
Met Asp Asp Ile Thr Asp Phe Glu Ser Asp Met Ser Asn Gly Phe Ala
    450                 455                 460                 
Ala Asn Ala Ile Asn Tyr Tyr Met Lys Gln Phe Val Val Thr Lys Glu
465                 470                 475                 480 
Glu Ala Ile Leu Glu Cys Gln Lys Met Val Val Asp Ile Asn Lys Ile
                485                 490                 495     
Val Asn Glu Glu Leu Leu Lys Thr Thr Thr Val Pro Arg Arg Val Leu
            500                 505                 510         
Lys Gln Ala Leu Asn Phe Gly Arg Leu Leu Glu Val Leu Tyr Thr Lys
        515                 520                 525             
Ser Asp Asp Ile Tyr Asn Cys Ser Glu Gly Lys Leu Lys Glu Tyr Ile
    530                 535                 540                 
Val Thr Leu Leu Ile Asp Pro Ile His Leu
545                 550                 


<210> 422
<211> 574
<212> PRT
<213> Artemisia annua

<220> 
<223> (E)-beta-farnesene synthase Acc. No. AAX39387

<400> 422
Met Ser Thr Leu Pro Ile Ser Ser Val Ser Phe Ser Ser Ser Thr Ser
 1               5                  10                  15      
Pro Leu Val Val Asp Asp Lys Val Ser Thr Lys Pro Asp Val Ile Arg
            20                  25                  30          
His Thr Met Asn Phe Asn Ala Ser Ile Trp Gly Asp Gln Phe Leu Thr
        35                  40                  45              
Tyr Asp Glu Pro Glu Asp Leu Val Met Lys Lys Gln Leu Val Glu Glu
    50                  55                  60                  
Leu Lys Glu Glu Val Lys Lys Glu Leu Ile Thr Ile Lys Gly Ser Asn
65                  70                  75                  80  
Glu Pro Met Gln His Val Lys Leu Ile Glu Leu Ile Asp Ala Val Gln
                85                  90                  95      
Arg Leu Gly Ile Ala Tyr His Phe Glu Glu Glu Ile Glu Glu Ala Leu
            100                 105                 110         
Gln His Ile His Val Thr Tyr Gly Glu Gln Trp Val Asp Lys Glu Asn
        115                 120                 125             
Leu Gln Ser Ile Ser Leu Trp Phe Arg Leu Leu Arg Gln Gln Gly Phe
    130                 135                 140                 
Asn Val Ser Ser Gly Val Phe Lys Asp Phe Met Asp Glu Lys Gly Lys
145                 150                 155                 160 
Phe Lys Glu Ser Leu Cys Asn Asp Ala Gln Gly Ile Leu Ala Leu Tyr
                165                 170                 175     
Glu Ala Ala Phe Met Arg Val Glu Asp Glu Thr Ile Leu Asp Asn Ala
            180                 185                 190         
Leu Glu Phe Thr Lys Val His Leu Asp Ile Ile Ala Lys Asp Pro Ser
        195                 200                 205             
Cys Asp Ser Ser Leu Arg Thr Gln Ile His Gln Ala Leu Lys Gln Pro
    210                 215                 220                 
Leu Arg Arg Arg Leu Ala Arg Ile Glu Ala Leu His Tyr Met Pro Ile
225                 230                 235                 240 
Tyr Gln Gln Glu Thr Ser His Asp Glu Val Leu Leu Lys Leu Ala Lys
                245                 250                 255     
Leu Asp Phe Ser Val Leu Gln Ser Met His Lys Lys Glu Leu Ser His
            260                 265                 270         
Ile Cys Lys Trp Trp Lys Asp Leu Asp Leu Gln Asn Lys Leu Pro Tyr
        275                 280                 285             
Val Arg Asp Arg Val Val Glu Gly Tyr Phe Trp Ile Leu Ser Ile Tyr
    290                 295                 300                 
Tyr Glu Pro Gln His Ala Arg Thr Arg Met Phe Leu Met Lys Thr Cys
305                 310                 315                 320 
Met Trp Leu Val Val Leu Asp Asp Thr Phe Asp Asn Tyr Gly Thr Tyr
                325                 330                 335     
Glu Glu Leu Glu Ile Phe Thr Gln Ala Val Glu Arg Trp Ser Ile Ser
            340                 345                 350         
Cys Leu Asp Met Leu Pro Glu Tyr Met Lys Leu Ile Tyr Gln Glu Leu
        355                 360                 365             
Val Asn Leu His Val Glu Met Glu Glu Ser Leu Glu Lys Glu Gly Lys
    370                 375                 380                 
Thr Tyr Gln Ile His Tyr Val Lys Glu Met Ala Lys Glu Leu Val Arg
385                 390                 395                 400 
Asn Tyr Leu Val Glu Ala Arg Trp Leu Lys Glu Gly Tyr Met Pro Thr
                405                 410                 415     
Leu Glu Glu Tyr Met Ser Val Ser Met Val Thr Gly Thr Tyr Gly Leu
            420                 425                 430         
Met Ile Ala Arg Ser Tyr Val Gly Arg Gly Asp Ile Val Thr Glu Asp
        435                 440                 445             
Thr Phe Lys Trp Val Ser Ser Tyr Pro Pro Ile Ile Lys Ala Ser Cys
    450                 455                 460                 
Val Ile Val Arg Leu Met Asp Asp Ile Val Ser His Lys Glu Glu Gln
465                 470                 475                 480 
Glu Arg Gly His Val Ala Ser Ser Ile Glu Cys Tyr Ser Lys Glu Ser
                485                 490                 495     
Gly Ala Ser Glu Glu Glu Ala Cys Glu Tyr Ile Ser Arg Lys Val Glu
            500                 505                 510         
Asp Ala Trp Lys Val Ile Asn Arg Glu Ser Leu Arg Pro Thr Ala Val
        515                 520                 525             
Pro Phe Pro Leu Leu Met Pro Ala Ile Asn Leu Ala Arg Met Cys Glu
    530                 535                 540                 
Val Leu Tyr Ser Val Asn Asp Gly Phe Thr His Ala Glu Gly Asp Met
545                 550                 555                 560 
Lys Ser Tyr Met Lys Ser Phe Phe Val His Pro Met Val Val
                565                 570                 


<210> 423
<211> 547
<212> PRT
<213> Artemisia annua

<220> 
<223> (8)-epi-cedrol synthase Acc. No. AAF80333

<400> 423
Met Ser Leu Ile Val Glu Asp Val Ile Arg Pro Asn Ala Asn Phe Pro
 1               5                  10                  15      
Ser Glu Ile Trp Gly Asp Gln Phe Leu Ala Tyr Asp Gln Asp Glu Gln
            20                  25                  30          
Glu Gly Val Glu Gln Val Ile Lys Asp Leu Lys Glu Glu Val Lys Ser
        35                  40                  45              
Glu Leu Leu Thr Ala Leu Asn Ser Pro Thr Gln His Thr Glu Leu Leu
    50                  55                  60                  
Lys Phe Ile Asp Ala Ile Glu Arg Leu Gly Ile Ala Tyr Tyr Phe Glu
65                  70                  75                  80  
Glu Glu Ile Asn Gln Val Phe Gln His Met Tyr Thr Ala Tyr Gly Asp
                85                  90                  95      
Lys Trp Thr Gly Gly Asn Thr Ser Leu Trp Phe Arg Leu Met Arg Gln
            100                 105                 110         
His Gly Phe Phe Val Ser Ser Asp Ile Phe Ser Thr Tyr Lys Asp Lys
        115                 120                 125             
Glu Gly Arg Phe Lys Glu Ser Leu Glu Lys Asp Val His Gly Leu Leu
    130                 135                 140                 
Glu Leu Tyr Glu Ala Ala Tyr Met Phe Val Pro Gly Glu Gly Ile Leu
145                 150                 155                 160 
Asp Asp Ala Leu Val Phe Thr Arg Thr Cys Leu Asp Glu Ile Ala Lys
                165                 170                 175     
Asn Pro Ser Leu Ser Asn Ser Ala Val Ser Ser Gln Ile Arg Glu Ala
            180                 185                 190         
Leu Thr Gln Pro Leu His Lys Arg Leu Pro Arg Leu Glu Ala Leu Arg
        195                 200                 205             
Tyr Ile Pro Phe Tyr Gln Gln Gln Ala Ser His Ser Glu Thr Leu Leu
    210                 215                 220                 
Lys Leu Ala Lys Leu Gly Phe Asn Gln Leu Gln Ser Leu His Lys Lys
225                 230                 235                 240 
Glu Leu Ser Ile Ile Ser Lys Trp Trp Lys Ser Phe Asp Val Ala Asn
                245                 250                 255     
Asn Leu Pro Tyr Ala Arg Asn Arg Pro Val Glu Cys Tyr Phe Trp Ala
            260                 265                 270         
Leu Ala Val Tyr Phe Glu Pro Gln Tyr Ser Glu Ser Arg Val Phe Leu
        275                 280                 285             
Ser Arg Phe Phe Ser Ile Gln Thr Phe Leu Asp Asp Thr Tyr Asp Ala
    290                 295                 300                 
Tyr Gly Thr Tyr Glu Glu Leu Glu Gln Phe Thr Glu Ala Ile Gln Arg
305                 310                 315                 320 
Trp Ser Ile Thr Cys Leu Asp Gly Leu Pro Glu Ser Met Lys Leu Ile
                325                 330                 335     
Phe Gln Met Leu Val Lys Ile Phe Glu Glu Ile Glu Glu Ile Leu Ser
            340                 345                 350         
Lys Asp Gly Lys Gln His His Val Asn Tyr Ile Lys Glu Thr Leu Lys
        355                 360                 365             
Glu Ala Val Gln Ser Tyr Met Thr Glu Ala Arg Trp Ala Lys Glu Glu
    370                 375                 380                 
Tyr Ile Pro Thr Ile Glu Glu His Thr Lys Val Ser Tyr Ile Ser Ile
385                 390                 395                 400 
Gly Tyr Lys Leu Ala Leu Val Ala Gly Phe Ala Cys Met Gly Asp Val
                405                 410                 415     
Ile Ala Asp Asp Ser Phe Glu Trp Val Phe Thr Asn Pro Pro Leu Val
            420                 425                 430         
Asn Ala Cys Cys Leu Leu Cys Arg Thr Met Asp Asp Leu Gly Ser His
        435                 440                 445             
Lys Gly Glu Gln Asp Arg Lys His Val Ala Ser Thr Ile Glu Cys Tyr
    450                 455                 460                 
Met Lys Gln Phe Asp Ala Ser Glu Gln Gln Ala Tyr Glu Ser Leu Asn
465                 470                 475                 480 
Lys Lys Val Glu Asp Ala Trp Lys Glu Ile Asn Arg Glu Phe Met Ile
                485                 490                 495     
Thr Cys Lys Asp Val Asn Ile His Val Ala Met Arg Val Leu Asn Phe
            500                 505                 510         
Ser Arg Ser Val Asp Val Leu Tyr Lys Asn Lys Asp His Phe Thr His
        515                 520                 525             
Val Gly Val Glu Val Ile Asn His Ile Lys Ser Leu Phe Val Asp Ala
    530                 535                 540                 
Ile Ile Thr
545         


<210> 424
<211> 547
<212> PRT
<213> Artemisia annua

<220> 
<223> (8)-epi-cedrol synthase Acc. No. CAC08805

<400> 424
Met Ser Leu Ile Val Glu Asp Val Ile Arg Pro Asn Ala Asn Phe Pro
 1               5                  10                  15      
Ser Glu Ile Trp Gly Asp Gln Phe Leu Ala Tyr Asp Gln Asp Glu Gln
            20                  25                  30          
Glu Gly Val Glu Gln Val Ile Lys Asp Leu Lys Glu Glu Val Lys Ser
        35                  40                  45              
Glu Leu Leu Thr Ala Leu Asn Ser Pro Thr Gln His Thr Glu Leu Leu
    50                  55                  60                  
Lys Phe Ile Asp Ala Ile Glu Arg Leu Gly Ile Ala Tyr Tyr Phe Glu
65                  70                  75                  80  
Glu Glu Ile Asn Gln Val Phe Gln His Met Tyr Thr Ala Tyr Gly Asp
                85                  90                  95      
Lys Trp Thr Gly Gly Asn Thr Ser Leu Trp Phe Arg Leu Met Arg Gln
            100                 105                 110         
His Gly Phe Phe Val Ser Ser Asp Ile Phe Ser Thr Tyr Lys Asp Lys
        115                 120                 125             
Glu Gly Arg Phe Lys Glu Ser Leu Glu Lys Asp Val His Gly Leu Leu
    130                 135                 140                 
Glu Leu Tyr Glu Ala Ala Tyr Met Phe Val Pro Gly Glu Gly Ile Leu
145                 150                 155                 160 
Asp Asp Ala Leu Val Phe Thr Arg Thr Cys Leu Asp Glu Ile Ala Lys
                165                 170                 175     
Asn Pro Ser Leu Ser Asn Ser Ala Val Ser Ser Gln Ile Arg Glu Ala
            180                 185                 190         
Leu Thr Gln Pro Leu His Lys Arg Leu Pro Arg Leu Glu Ala Leu Arg
        195                 200                 205             
Tyr Ile Pro Phe Tyr Gln Gln Gln Ala Ser His Ser Glu Thr Leu Leu
    210                 215                 220                 
Lys Leu Ala Lys Leu Gly Phe Asn Gln Leu Gln Ser Leu His Lys Lys
225                 230                 235                 240 
Glu Leu Ser Ile Ile Ser Lys Trp Trp Lys Ser Phe Asp Val Ala Asn
                245                 250                 255     
Asn Leu Pro Tyr Ala Arg Asn Arg Pro Val Glu Cys Tyr Phe Trp Ala
            260                 265                 270         
Leu Ala Val Tyr Phe Glu Pro Gln Tyr Ser Glu Ser Arg Val Phe Leu
        275                 280                 285             
Ser Arg Phe Phe Ser Ile Gln Thr Phe Leu Asp Asp Thr Tyr Asp Ala
    290                 295                 300                 
Tyr Gly Thr Tyr Glu Glu Leu Glu Gln Phe Thr Glu Ala Ile Gln Arg
305                 310                 315                 320 
Trp Ser Ile Thr Cys Leu Asp Gly Leu Pro Glu Ser Met Lys Leu Ile
                325                 330                 335     
Phe Gln Met Leu Val Lys Ile Phe Glu Glu Ile Glu Glu Ile Leu Ser
            340                 345                 350         
Lys Asp Gly Lys Gln His His Val Asn Tyr Ile Lys Glu Thr Leu Lys
        355                 360                 365             
Glu Ala Val Gln Ser Tyr Met Thr Glu Ala Arg Trp Ala Lys Glu Glu
    370                 375                 380                 
Tyr Ile Pro Thr Ile Glu Glu His Thr Lys Val Ser Tyr Ile Ser Ile
385                 390                 395                 400 
Gly Tyr Lys Leu Ala Leu Val Ala Gly Phe Ala Cys Met Gly Asp Val
                405                 410                 415     
Ile Ala Asp Asp Ser Phe Glu Trp Val Phe Thr Asn Pro Pro Leu Val
            420                 425                 430         
Asn Ala Cys Cys Leu Leu Cys Arg Thr Met Asp Asp Leu Gly Ser His
        435                 440                 445             
Lys Gly Glu Gln Asp Arg Lys His Val Ala Ser Thr Ile Glu Cys Tyr
    450                 455                 460                 
Met Lys Gln Phe Asp Ala Ser Glu Gln Gln Ala Tyr Glu Ser Leu Asn
465                 470                 475                 480 
Lys Lys Val Glu Asp Ala Trp Lys Glu Ile Asn Arg Glu Phe Met Ile
                485                 490                 495     
Thr Cys Lys Asp Val Asn Ile His Val Ala Met Arg Val Leu Asn Phe
            500                 505                 510         
Ser Arg Ser Val Asp Val Leu Tyr Lys Asn Lys Asp His Phe Thr His
        515                 520                 525             
Val Gly Val Glu Val Ile Asn His Ile Lys Ser Leu Phe Val Asp Ala
    530                 535                 540                 
Ile Ile Thr
545         


<210> 425
<211> 548
<212> PRT
<213> Artemisia annua

<220> 
<223> ((E)-beta-caryophyllene synthase Acc. No. AAL79181

<400> 425
Met Ser Val Lys Glu Glu Lys Val Ile Arg Pro Ile Val His Phe Pro
 1               5                  10                  15      
Pro Ser Val Trp Ala Asp Gln Phe Leu Ile Phe Asp Asp Lys Gln Ala
            20                  25                  30          
Glu Gln Ala Asn Val Glu Gln Val Val Asn Glu Leu Arg Glu Asp Val
        35                  40                  45              
Arg Lys Asp Leu Val Ser Ser Leu Asp Val Gln Thr Glu His Thr Asn
    50                  55                  60                  
Leu Leu Lys Leu Ile Asp Ala Ile Gln Arg Leu Gly Ile Ala Tyr His
65                  70                  75                  80  
Phe Glu Glu Glu Ile Glu Gln Ala Leu Gln His Ile Tyr Asp Thr Tyr
                85                  90                  95      
Gly Asp Asp Trp Lys Gly Arg Ser Pro Ser Leu Trp Phe Arg Ile Leu
            100                 105                 110         
Arg Gln Gln Gly Phe Tyr Val Ser Cys Asp Ile Phe Lys Asn Tyr Lys
        115                 120                 125             
Lys Glu Asp Gly Ser Phe Lys Glu Ser Leu Thr Asn Asp Val Glu Gly
    130                 135                 140                 
Leu Leu Glu Leu Tyr Glu Ala Thr Tyr Leu Arg Val Gln Gly Glu Gly
145                 150                 155                 160 
Val Leu Asp Asp Ala Leu Val Phe Thr Arg Thr Cys Leu Glu Lys Ile
                165                 170                 175     
Ala Lys Asp Leu Val His Thr Asn Pro Thr Leu Ser Thr Tyr Ile Gln
            180                 185                 190         
Glu Ala Leu Lys Gln Pro Leu His Lys Arg Leu Thr Arg Leu Glu Ala
        195                 200                 205             
Leu Arg Tyr Ile Pro Met Tyr Glu Gln Gln Ala Ser His Asn Glu Ser
    210                 215                 220                 
Leu Leu Lys Leu Ala Lys Leu Gly Phe Asn Leu Leu Gln Ser Leu His
225                 230                 235                 240 
Arg Lys Glu Leu Ser Glu Val Ser Arg Trp Trp Lys Gly Leu Asp Val
                245                 250                 255     
Pro Asn Asn Leu Pro Tyr Ala Arg Asp Arg Met Val Glu Cys Tyr Phe
            260                 265                 270         
Trp Ala Leu Gly Val Tyr Phe Glu Pro Lys Tyr Ser Gln Ala Arg Ile
        275                 280                 285             
Phe Leu Ala Lys Val Ile Ser Leu Ala Thr Val Leu Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Tyr Glu Glu Leu Lys Ile Phe Thr Glu Ala Ile
305                 310                 315                 320 
Gln Arg Trp Ser Ile Thr Cys Ile Asp Met Leu Pro Glu Tyr Leu Lys
                325                 330                 335     
Leu Leu Tyr Gln Gly Val Leu Asp Ile Tyr Ile Glu Met Glu Glu Ile
            340                 345                 350         
Met Gly Lys Glu Gly Lys Ala His His Leu Ser Tyr Ala Lys Glu Ser
        355                 360                 365             
Met Lys Glu Phe Ile Arg Ser Tyr Met Met Glu Ala Lys Trp Ala Asn
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ala Glu Glu His Met Ser Val Ala Phe Val
385                 390                 395                 400 
Ser Ser Gly Tyr Ser Met Leu Ala Thr Thr Cys Phe Val Gly Met Gly
                405                 410                 415     
Asp Ile Val Thr Asp Glu Ala Phe Lys Trp Ala Leu Thr Lys Pro Pro
            420                 425                 430         
Ile Ile Lys Ala Ser Cys Ala Ile Ala Arg Leu Met Asp Asp Ile His
        435                 440                 445             
Ser Gln Lys Glu Glu Lys Glu Arg Ile His Val Ala Ser Ser Val Glu
    450                 455                 460                 
Ser Tyr Met Lys Gln Tyr Asp Val Thr Glu Glu His Val Leu Lys Val
465                 470                 475                 480 
Phe Asn Lys Lys Ile Glu Asp Ala Trp Lys Asp Ile Thr Arg Glu Ser
                485                 490                 495     
Leu Val Arg Lys Asp Ile Pro Met Pro Leu Met Met Arg Val Ile Asn
            500                 505                 510         
Leu Ala Gln Val Met Asp Val Leu Tyr Lys His Lys Asp Gly Phe Thr
        515                 520                 525             
Asn Val Gly Glu Glu Leu Lys Asp His Ile Lys Ser Leu Leu Val His
    530                 535                 540                 
Pro Ile Pro Ile
545             


<210> 426
<211> 320
<212> PRT
<213> Aspergillus terreus

<220> 
<223> aristolochene synthase Acc. No. AAF13263

<400> 426
Met Lys Lys Pro Asn Gly Thr Asn Gly Ala Ser Ser Ser Leu Glu Pro
 1               5                  10                  15      
Pro Pro Ser Thr Phe Gln Pro Leu Cys His Pro Leu Val Glu Glu Val
            20                  25                  30          
Ser Lys Glu Val Asp Gly Tyr Phe Leu Gln His Trp Asn Phe Pro Asn
        35                  40                  45              
Glu Lys Ala Arg Lys Lys Phe Val Ala Ala Gly Phe Ser Arg Val Thr
    50                  55                  60                  
Cys Leu Tyr Phe Pro Lys Ala Leu Asp Asp Arg Ile His Phe Ala Cys
65                  70                  75                  80  
Arg Leu Leu Thr Val Leu Phe Leu Ile Asp Asp Leu Leu Glu Tyr Met
                85                  90                  95      
Ser Phe Glu Glu Gly Ser Ala Tyr Asn Glu Lys Leu Ile Pro Ile Ser
            100                 105                 110         
Arg Gly Asp Val Leu Pro Asp Arg Ser Ile Pro Val Glu Tyr Ile Ile
        115                 120                 125             
Tyr Asp Leu Trp Glu Ser Met Arg Ala His Asp Arg Glu Met Ala Asp
    130                 135                 140                 
Glu Ile Leu Glu Pro Val Phe Leu Phe Met Arg Ala Gln Thr Asp Arg
145                 150                 155                 160 
Thr Arg Ala Arg Pro Met Gly Leu Gly Gly Tyr Leu Glu Tyr Arg Glu
                165                 170                 175     
Arg Asp Val Gly Lys Glu Leu Leu Ala Ala Leu Met Arg Phe Ser Met
            180                 185                 190         
Gly Leu Lys Leu Ser Pro Ser Glu Leu Gln Arg Val Arg Glu Ile Asp
        195                 200                 205             
Ala Asn Cys Ser Lys His Leu Ser Val Val Asn Asp Ile Tyr Ser Tyr
    210                 215                 220                 
Glu Lys Glu Leu Tyr Thr Ser Lys Thr Ala His Ser Glu Gly Gly Ile
225                 230                 235                 240 
Leu Cys Thr Ser Val Gln Ile Leu Ala Gln Glu Ala Asp Val Thr Ala
                245                 250                 255     
Glu Ala Ala Lys Arg Val Leu Phe Val Met Cys Arg Glu Trp Glu Leu
            260                 265                 270         
Arg His Gln Leu Leu Val Ala Arg Leu Ser Ala Glu Gly Leu Glu Thr
        275                 280                 285             
Pro Gly Leu Ala Ala Tyr Val Glu Gly Leu Glu Tyr Gln Met Ser Gly
    290                 295                 300                 
Asn Glu Leu Trp Ser Gln Thr Thr Leu Arg Tyr Ser Val Val Val Asp
305                 310                 315                 320 


<210> 427
<211> 560
<212> PRT
<213> Cucumis melo

<220> 
<223> alpha-farnesene synthase Acc. No. ABX83201

<400> 427
Met Ser Ser Asn Ile Ser Ala Ile Pro Asn Ser Leu Glu Val Ile Arg
 1               5                  10                  15      
Arg Ser Ala Gln Phe Gln Ala Ser Val Trp Gly Asp Tyr Phe Leu Ser
            20                  25                  30          
Tyr His Ser Leu Ser Pro Glu Lys Gly Asn Lys Val Met Glu Lys Gln
        35                  40                  45              
Thr Glu Glu Leu Lys Glu Glu Ile Lys Arg Glu Leu Asn Ser Thr Thr
    50                  55                  60                  
Lys Asp Glu Glu Pro Glu Lys Leu Arg Leu Ile Asp Ser Ile Gln Arg
65                  70                  75                  80  
Leu Gly Val Cys Tyr His Phe Glu Tyr Glu Ile Asn Lys Ile Leu Glu
                85                  90                  95      
Gln Leu His His Ile Thr Ile Thr Ser Lys Asn Asn Gly Asp Asp His
            100                 105                 110         
Pro Tyr Asn Met Thr Leu Arg Phe Arg Leu Leu Arg Gln Gln Gly Tyr
        115                 120                 125             
Asn Ile Ser Ser Lys Ser Phe Glu Arg Phe Arg Gly Lys Trp Glu Ser
    130                 135                 140                 
Ser Tyr Asp Lys Asn Val Glu Glu Leu Leu Ser Leu Tyr Glu Ala Ser
145                 150                 155                 160 
Gln Leu Arg Met Arg Gly Glu Glu Ala Leu Asp Glu Ala Phe Arg Phe
                165                 170                 175     
Ala Thr Ala Gln Leu Glu Ala Ile Val Gln Asp Pro Thr Thr Asp Pro
            180                 185                 190         
Thr Val Val Gly Glu Val Cys Gln Ala Leu Lys Trp Pro Met Tyr Lys
        195                 200                 205             
Asn Leu Pro Arg Leu Gln Ala Ser His Tyr Ile Gly Leu Tyr Ser Glu
    210                 215                 220                 
Lys Pro Trp Arg Asn Glu Ser Leu Pro Asn Phe Ala Lys Met Asp Phe
225                 230                 235                 240 
Ser Lys Leu Gln Lys Leu His Gln Lys Glu Ile Ala Tyr Ile Ser Lys
                245                 250                 255     
Trp Trp Asp Asp Tyr Gly Phe Ala Glu Lys Leu Ser Phe Ala Arg Asn
            260                 265                 270         
Arg Ile Val Glu Gly Tyr Phe Phe Ala Leu Gly Ile Phe Phe Glu Pro
        275                 280                 285             
Gln Leu Ser Thr Ala Arg Leu Ile Met Thr Lys Ile Ile Ala Ile Gly
    290                 295                 300                 
Ser Val Leu Asp Asp Ile Tyr Asp Val Tyr Gly Thr Phe Glu Glu Leu
305                 310                 315                 320 
Lys Leu Leu Thr Leu Ala Leu Glu Arg Trp Asp Lys Ser Glu Thr Lys
                325                 330                 335     
Lys Leu Pro Lys Tyr Met Lys Met Tyr Tyr Glu Ala Leu Leu Asp Val
            340                 345                 350         
Phe Glu Glu Ile Glu Gln Glu Met Ser Gln Lys Glu Thr Thr Pro Tyr
        355                 360                 365             
Cys Ile His Gln Met Lys Glu Ala Thr Lys Glu Leu Gly Arg Val Phe
    370                 375                 380                 
Leu Val Glu Ala Lys Trp Cys Lys Glu Gly Tyr Thr Pro Thr Val Glu
385                 390                 395                 400 
Glu Tyr Leu Asp Ile Ala Leu Ile Ser Phe Gly His Lys Leu Leu Met
                405                 410                 415     
Val Thr Ala Leu Leu Gly Met Gly Ser Thr Ile Ala Thr Gln Gln Ile
            420                 425                 430         
Val Gln Trp Ile Thr Ser Met Pro Asn Ile Leu Lys Ala Ser Ala Ile
        435                 440                 445             
Ile Cys Arg Leu Met Asn Asp Ile Val Ser His Lys Phe Glu Gln Glu
    450                 455                 460                 
Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr Met Glu Gln Asn Tyr
465                 470                 475                 480 
Met Ser Glu His Asp Val Leu Ile Ile Leu Gly Lys Gln Ile Asp Glu
                485                 490                 495     
Phe Trp Lys Asp Met Val Glu Asn Tyr Cys Val Val Ile Thr Glu Glu
            500                 505                 510         
Glu Val Pro Arg Gly Val Leu Met Arg Val Leu Asn Leu Thr Arg Leu
        515                 520                 525             
Phe Asn Val Ile Tyr Lys Asp Gly Asp Gly Tyr Thr Gln Ser His Gly
    530                 535                 540                 
Ser Thr Lys Thr His Ile Lys Ser Leu Leu Val Asp Ser Leu Pro Leu
545                 550                 555                 560 


<210> 428
<211> 567
<212> PRT
<213> Cucumis sativus

<220> 
<223> (E,E)-alpha-caryophyllene synthase Acc. No.
      AAU05952

<400> 428
Met Ser Ser His Phe Pro Ala Ser Ile Met Lys Thr Asn Asp Ile Tyr
 1               5                  10                  15      
Asp Thr Lys Arg Ser Leu Ala Asn Phe His Pro Thr Ile Trp Lys Glu
            20                  25                  30          
His Phe Leu Ser Phe Thr Phe Asp Asp Ala Leu Lys Val Asp Gly Gly
        35                  40                  45              
Met Lys Glu Arg Ile Glu Lys Leu Lys Glu Glu Ile Arg Met Met Val
    50                  55                  60                  
Ile Ala Ser Val Gln Asn Pro Leu Val Lys Leu Asn Leu Val Asp Ser
65                  70                  75                  80  
Ile Gln Arg Leu Gly Val Ser Tyr His Phe Glu Asp Glu Ile Asp Gln
                85                  90                  95      
Phe Leu Glu His Met Tyr Val Ser Tyr Asn Asn Ser Leu Leu Phe Ser
            100                 105                 110         
Ser Asn Asp Ser Gln Asp Asp Asp Leu His Ile Ser Ala Leu Leu Phe
        115                 120                 125             
Arg Leu Leu Arg Gln His Gly Tyr Arg Ile Ser Cys Asp Ile Phe Leu
    130                 135                 140                 
Lys Phe Met Asp Asn Asn Gly Lys Phe Lys Glu Ser Leu Val Glu Asp
145                 150                 155                 160 
Glu Arg Gly Ile Leu Ser Leu Tyr Glu Ala Ser His Met Arg Gly His
                165                 170                 175     
Gly Glu Ala Leu Leu Glu Glu Ala Leu Glu Phe Thr Thr Thr His Leu
            180                 185                 190         
Lys Ala Tyr Ile His Leu Tyr Ser Asn Ile Asn Pro Asn Phe Ala Ser
        195                 200                 205             
Glu Val Ser Asn Ala Leu Lys Leu Pro Ile Arg Lys Cys Val Pro Arg
    210                 215                 220                 
Val Lys Ala Arg Glu Tyr Phe Glu Ile Tyr Gln Gln Gln Pro Ser His
225                 230                 235                 240 
Asn Glu Thr Leu Leu Thr Phe Ser Lys Leu Asp Phe Asn Ile Leu Gln
                245                 250                 255     
Lys Leu His Gln Lys Glu Ile Ala Glu Ile Cys Arg Trp Trp Lys Asp
            260                 265                 270         
Leu Asn Val Ser Thr Asn Phe Pro Phe Ala Arg Asp Arg Ile Val Glu
        275                 280                 285             
Cys Tyr Phe Trp Ile Leu Ser Ile Tyr Phe Glu Pro Tyr Phe Lys Phe
    290                 295                 300                 
Gly Arg Lys Ile Leu Thr Lys Val Ile Ala Met Thr Ser Ile Met Asp
305                 310                 315                 320 
Asp Ile Tyr Asp Ala Tyr Gly Thr Phe Glu Glu Leu Gln Leu Phe Thr
                325                 330                 335     
Leu Ala Ile Lys Arg Trp Asp Met Ser Met Val Asn Leu Leu Pro Gln
            340                 345                 350         
Tyr Met Lys Val His Tyr Thr Thr Leu Leu Asp Leu Phe Glu Glu Met
        355                 360                 365             
Asp Lys Gly Ile Val Asn Asp Gly Ile Ser Tyr Arg Ser Cys Phe Gly
    370                 375                 380                 
Lys Glu Ala Met Lys Arg Gln Ala Glu Ser Tyr Phe Lys Glu Ala Glu
385                 390                 395                 400 
Trp Leu Asn Lys Asn Tyr Lys Pro Lys Tyr Gly Glu Tyr Met Glu Val
                405                 410                 415     
Ala Leu Ala Ser Ser Gly Tyr Glu Leu Leu Ser Thr Ile Ser Phe Val
            420                 425                 430         
Cys Met Gly Asp Ile Ala Thr Lys Glu Val Phe Glu Trp Leu Phe Asp
        435                 440                 445             
Cys Pro Gln Ile Leu Lys Ala Ser Thr Thr Ile Ser Arg Leu Met Asp
    450                 455                 460                 
Asp Val Val Ser Tyr Lys Phe Glu Lys Glu Arg Glu His Ile Val Ser
465                 470                 475                 480 
Ala Val Glu Cys Tyr Met Ser Asn His Gly Arg Ser Glu Asp Glu Thr
                485                 490                 495     
Cys Ala Glu Leu Leu Lys Gln Val Glu Asp Ala Trp Lys Thr Ile Asn
            500                 505                 510         
Glu Cys Cys Leu His Pro Met Asn Val Pro Met Pro Phe Leu Ile Cys
        515                 520                 525             
Leu Leu Asn Leu Thr Arg Val Met Ala Leu Leu Tyr Ser His Glu Asp
    530                 535                 540                 
Gly Tyr Thr Asn Ser Lys Gly Arg Thr Lys Leu Leu Ile Gln Ser Leu
545                 550                 555                 560 
Leu Ile Asp Pro Leu His Leu
                565         


<210> 429
<211> 561
<212> PRT
<213> Cucumis sativus

<220> 
<223> (E)-alpha-farnesene synthase Acc. No. AAU05951

<400> 429
Met Ser Ser Asn Val Ser Ala Ile Pro Asn Ser Phe Glu Leu Ile Arg
 1               5                  10                  15      
Arg Ser Ala Gln Phe Gln Ala Ser Val Trp Gly Asp Tyr Phe Leu Ser
            20                  25                  30          
Tyr His Ser Leu Pro Pro Glu Lys Gly Asn Lys Val Met Glu Lys Gln
        35                  40                  45              
Thr Glu Glu Leu Lys Glu Glu Ile Lys Met Glu Leu Val Ser Thr Thr
    50                  55                  60                  
Lys Asp Glu Pro Glu Lys Leu Arg Leu Ile Asp Leu Ile Gln Arg Leu
65                  70                  75                  80  
Gly Val Cys Tyr His Phe Glu Asn Glu Ile Asn Asn Ile Leu Gln Gln
                85                  90                  95      
Leu His His Ile Thr Ile Thr Ser Glu Lys Asn Gly Asp Asp Asn Pro
            100                 105                 110         
Tyr Asn Met Thr Leu Cys Phe Arg Leu Leu Arg Gln Gln Gly Tyr Asn
        115                 120                 125             
Val Ser Ser Glu Pro Phe Asp Arg Phe Arg Gly Lys Trp Glu Ser Ser
    130                 135                 140                 
Tyr Asp Asn Asn Val Glu Glu Leu Leu Ser Leu Tyr Glu Ala Ser Gln
145                 150                 155                 160 
Leu Arg Met Gln Gly Glu Glu Ala Leu Asp Glu Ala Phe Cys Phe Ala
                165                 170                 175     
Thr Ala Gln Leu Glu Ala Ile Val Gln Asp Pro Thr Thr Asp Pro Met
            180                 185                 190         
Val Ala Ala Glu Ile Arg Gln Ala Leu Lys Trp Pro Met Tyr Lys Asn
        195                 200                 205             
Leu Pro Arg Leu Lys Ala Arg His His Ile Gly Leu Tyr Ser Glu Lys
    210                 215                 220                 
Pro Trp Arg Asn Glu Ser Leu Leu Asn Phe Ala Lys Met Asp Phe Asn
225                 230                 235                 240 
Lys Leu Gln Asn Leu His Gln Thr Glu Ile Ala Tyr Ile Ser Lys Trp
                245                 250                 255     
Trp Asp Asp Tyr Gly Phe Ala Glu Lys Leu Ser Phe Ala Arg Asn Arg
            260                 265                 270         
Ile Val Glu Gly Tyr Phe Phe Ala Leu Gly Ile Phe Phe Glu Pro Gln
        275                 280                 285             
Leu Leu Thr Ala Arg Leu Ile Met Thr Lys Val Ile Ala Ile Gly Ser
    290                 295                 300                 
Met Leu Asp Asp Ile Tyr Asp Val Tyr Gly Thr Phe Glu Glu Leu Lys
305                 310                 315                 320 
Leu Leu Thr Leu Ala Leu Glu Arg Trp Asp Lys Ser Glu Thr Lys Gln
                325                 330                 335     
Leu Pro Asn Tyr Met Lys Met Tyr Tyr Glu Ala Leu Leu Asp Val Phe
            340                 345                 350         
Glu Glu Ile Glu Gln Glu Met Ser Gln Lys Glu Thr Glu Thr Thr Pro
        355                 360                 365             
Tyr Cys Ile His His Met Lys Glu Ala Thr Lys Glu Leu Gly Arg Val
    370                 375                 380                 
Phe Leu Val Glu Ala Thr Trp Cys Lys Glu Gly Tyr Thr Pro Lys Val
385                 390                 395                 400 
Glu Glu Tyr Leu Asp Ile Ala Leu Ile Ser Phe Gly His Lys Leu Leu
                405                 410                 415     
Met Val Thr Ala Leu Leu Gly Met Gly Ser His Met Ala Thr Gln Gln
            420                 425                 430         
Ile Val Gln Trp Ile Thr Ser Met Pro Asn Ile Leu Lys Ala Ser Ala
        435                 440                 445             
Val Ile Cys Arg Leu Met Asn Asp Ile Val Ser His Lys Phe Glu Gln
    450                 455                 460                 
Glu Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr Met Glu Gln Asn
465                 470                 475                 480 
His Leu Ser Glu Tyr Glu Ala Leu Ile Ala Leu Arg Lys Gln Ile Asp
                485                 490                 495     
Asp Leu Trp Lys Asp Met Val Glu Asn Tyr Cys Ala Val Ile Thr Glu
            500                 505                 510         
Asp Glu Val Pro Arg Gly Val Leu Met Arg Val Leu Asn Leu Thr Arg
        515                 520                 525             
Leu Phe Asn Val Ile Tyr Lys Asp Gly Asp Gly Tyr Thr Gln Ser His
    530                 535                 540                 
Gly Ser Thr Lys Ala His Ile Lys Ser Leu Leu Val Asp Ser Val Pro
545                 550                 555                 560 
Leu
    


<210> 430
<211> 952
<212> PRT
<213> Giberella fujikuroi

<220> 
<223> (-)-copalyl diphosphate/(-)-ent-kaurene synthase
      Acc. No. Q9UVY5

<400> 430
Met Pro Gly Lys Ile Glu Asn Gly Thr Pro Lys Asp Leu Lys Thr Gly
 1               5                  10                  15      
Asn Asp Phe Val Ser Ala Ala Lys Ser Leu Leu Asp Arg Ala Phe Lys
            20                  25                  30          
Ser His His Ser Tyr Tyr Gly Leu Cys Ser Thr Ser Cys Gln Val Tyr
        35                  40                  45              
Asp Thr Ala Trp Val Ala Met Ile Pro Lys Thr Arg Asp Asn Val Lys
    50                  55                  60                  
Gln Trp Leu Phe Pro Glu Cys Phe His Tyr Leu Leu Lys Thr Gln Ala
65                  70                  75                  80  
Ala Asp Gly Ser Trp Gly Ser Leu Pro Thr Thr Gln Thr Ala Gly Ile
                85                  90                  95      
Leu Asp Thr Ala Ser Ala Val Leu Ala Leu Leu Cys His Ala Gln Glu
            100                 105                 110         
Pro Leu Gln Ile Leu Asp Val Ser Pro Asp Glu Met Gly Leu Arg Ile
        115                 120                 125             
Glu His Gly Val Thr Ser Leu Lys Arg Gln Leu Ala Val Trp Asn Asp
    130                 135                 140                 
Val Glu Asp Thr Asn His Ile Gly Val Glu Phe Ile Ile Pro Ala Leu
145                 150                 155                 160 
Leu Ser Met Leu Glu Lys Glu Leu Asp Val Pro Ser Phe Glu Phe Pro
                165                 170                 175     
Cys Arg Ser Ile Leu Glu Arg Met His Gly Glu Lys Leu Gly His Phe
            180                 185                 190         
Asp Leu Glu Gln Val Tyr Gly Lys Pro Ser Ser Leu Leu His Ser Leu
        195                 200                 205             
Glu Ala Phe Leu Gly Lys Leu Asp Phe Asp Arg Leu Ser His His Leu
    210                 215                 220                 
Tyr His Gly Ser Met Met Ala Ser Pro Ser Ser Thr Ala Ala Tyr Leu
225                 230                 235                 240 
Ile Gly Ala Thr Lys Trp Asp Asp Glu Ala Glu Asp Tyr Leu Arg His
                245                 250                 255     
Val Met Arg Asn Gly Ala Gly His Gly Asn Gly Gly Ile Ser Gly Thr
            260                 265                 270         
Phe Pro Thr Thr His Phe Glu Cys Ser Trp Ile Ile Ala Thr Leu Leu
        275                 280                 285             
Lys Val Gly Phe Thr Leu Lys Gln Ile Asp Gly Asp Gly Leu Arg Gly
    290                 295                 300                 
Leu Ser Thr Ile Leu Leu Glu Ala Leu Arg Asp Glu Asn Gly Val Ile
305                 310                 315                 320 
Gly Phe Ala Pro Arg Thr Ala Asp Val Asp Asp Thr Ala Lys Ala Leu
                325                 330                 335     
Leu Ala Leu Ser Leu Val Asn Gln Pro Val Ser Pro Asp Ile Met Ile
            340                 345                 350         
Lys Val Phe Glu Gly Lys Asp His Phe Thr Thr Phe Gly Ser Glu Arg
        355                 360                 365             
Asp Pro Ser Leu Thr Ser Asn Leu His Val Leu Leu Ser Leu Leu Lys
    370                 375                 380                 
Gln Ser Asn Leu Ser Gln Tyr His Pro Gln Ile Leu Lys Thr Thr Leu
385                 390                 395                 400 
Phe Thr Cys Arg Trp Trp Trp Gly Ser Asp His Cys Val Lys Asp Lys
                405                 410                 415     
Trp Asn Leu Ser His Leu Tyr Pro Thr Met Leu Leu Val Glu Ala Phe
            420                 425                 430         
Thr Glu Val Leu His Leu Ile Asp Gly Gly Glu Leu Ser Ser Leu Phe
        435                 440                 445             
Asp Glu Ser Phe Lys Cys Lys Ile Gly Leu Ser Ile Phe Gln Ala Val
    450                 455                 460                 
Leu Arg Ile Ile Leu Thr Gln Asp Asn Asp Gly Ser Trp Arg Gly Tyr
465                 470                 475                 480 
Arg Glu Gln Thr Cys Tyr Ala Ile Leu Ala Leu Val Gln Ala Arg His
                485                 490                 495     
Val Cys Phe Phe Thr His Met Val Asp Arg Leu Gln Ser Cys Val Asp
            500                 505                 510         
Arg Gly Phe Ser Trp Leu Lys Ser Cys Ser Phe His Ser Gln Asp Leu
        515                 520                 525             
Thr Trp Thr Ser Lys Thr Ala Tyr Glu Val Gly Phe Val Ala Glu Ala
    530                 535                 540                 
Tyr Lys Leu Ala Ala Leu Gln Ser Ala Ser Leu Glu Val Pro Ala Ala
545                 550                 555                 560 
Thr Ile Gly His Ser Val Thr Ser Ala Val Pro Ser Ser Asp Leu Glu
                565                 570                 575     
Lys Tyr Met Arg Leu Val Arg Lys Thr Ala Leu Phe Ser Pro Leu Asp
            580                 585                 590         
Glu Trp Gly Leu Met Ala Ser Ile Ile Glu Ser Ser Phe Phe Val Pro
        595                 600                 605             
Leu Leu Gln Ala Gln Arg Val Glu Ile Tyr Pro Arg Asp Asn Ile Lys
    610                 615                 620                 
Val Asp Glu Asp Lys Tyr Leu Ser Ile Ile Pro Phe Thr Trp Val Gly
625                 630                 635                 640 
Cys Asn Asn Arg Ser Arg Thr Phe Ala Ser Asn Arg Trp Leu Tyr Asp
                645                 650                 655     
Met Met Tyr Leu Ser Leu Leu Gly Tyr Gln Thr Asp Glu Tyr Met Glu
            660                 665                 670         
Ala Val Ala Gly Pro Val Phe Gly Asp Val Ser Leu Leu His Gln Thr
        675                 680                 685             
Ile Asp Lys Val Ile Asp Asn Thr Met Gly Asn Leu Ala Arg Ala Asn
    690                 695                 700                 
Gly Thr Val His Ser Gly Asn Gly His Gln His Glu Ser Pro Asn Ile
705                 710                 715                 720 
Gly Gln Val Glu Asp Thr Leu Thr Arg Phe Thr Asn Ser Val Leu Asn
                725                 730                 735     
His Lys Asp Val Leu Asn Ser Ser Ser Ser Asp Gln Asp Thr Leu Arg
            740                 745                 750         
Arg Glu Phe Arg Thr Phe Met His Ala His Ile Thr Gln Ile Glu Asp
        755                 760                 765             
Asn Ser Arg Phe Ser Lys Gln Ala Ser Ser Asp Ala Phe Ser Ser Pro
    770                 775                 780                 
Glu Gln Ser Tyr Phe Gln Trp Val Asn Ser Thr Gly Gly Ser His Val
785                 790                 795                 800 
Ala Cys Ala Tyr Ser Phe Ala Phe Ser Asn Cys Leu Met Ser Ala Asn
                805                 810                 815     
Leu Leu Gln Gly Lys Asp Ala Phe Pro Ser Gly Thr Gln Lys Tyr Leu
            820                 825                 830         
Ile Ser Ser Val Met Arg His Ala Thr Asn Met Cys Arg Met Tyr Asn
        835                 840                 845             
Asp Phe Gly Ser Ile Ala Arg Asp Asn Ala Glu Arg Asn Val Asn Ser
    850                 855                 860                 
Ile His Phe Pro Glu Phe Thr Leu Cys Asn Gly Thr Ser Gln Asn Leu
865                 870                 875                 880 
Asp Glu Arg Lys Glu Arg Leu Leu Lys Ile Ala Thr Tyr Glu Gln Gly
                885                 890                 895     
Tyr Leu Asp Arg Ala Leu Glu Ala Leu Glu Arg Gln Ser Arg Asp Asp
            900                 905                 910         
Ala Gly Asp Arg Ala Gly Ser Lys Asp Met Arg Lys Leu Lys Ile Val
        915                 920                 925             
Lys Leu Phe Cys Asp Val Thr Asp Leu Tyr Asp Gln Leu Tyr Val Ile
    930                 935                 940                 
Lys Asp Leu Ser Ser Ser Met Lys
945                 950         


<210> 431
<211> 554
<212> PRT
<213> Gossypium arboreum

<220> 
<223> (+)-alpha-cadinene synthase Acc. No. AAA93064

<400> 431
Met Ala Ser Gln Val Ser Gln Met Pro Ser Ser Ser Pro Leu Ser Ser
 1               5                  10                  15      
Asn Lys Asp Glu Met Arg Pro Lys Ala Asp Phe Gln Pro Ser Ile Trp
            20                  25                  30          
Gly Asp Leu Phe Leu Asn Cys Pro Asp Lys Asn Ile Asp Ala Glu Thr
        35                  40                  45              
Glu Lys Arg His Gln Gln Leu Lys Glu Glu Val Arg Lys Met Ile Val
    50                  55                  60                  
Ala Pro Met Ala Asn Ser Thr Gln Lys Leu Ala Phe Ile Asp Ser Val
65                  70                  75                  80  
Gln Arg Leu Gly Val Ser Tyr His Phe Thr Lys Glu Ile Glu Asp Glu
                85                  90                  95      
Leu Glu Asn Ile Tyr His Asn Asn Asn Asp Ala Glu Asn Asp Leu Tyr
            100                 105                 110         
Thr Thr Ser Ile Arg Phe Arg Leu Leu Arg Glu His Gly Tyr Asn Val
        115                 120                 125             
Ser Cys Asp Val Phe Asn Lys Phe Lys Asp Glu Gln Gly Asn Phe Lys
    130                 135                 140                 
Ser Ser Val Thr Ser Asp Val Arg Gly Leu Leu Glu Leu Tyr Gln Ala
145                 150                 155                 160 
Ser Tyr Leu Arg Val His Gly Glu Asp Ile Leu Asp Glu Ala Ile Ser
                165                 170                 175     
Phe Thr Thr His His Leu Ser Leu Ala Val Ala Ser Leu Asp His Pro
            180                 185                 190         
Leu Ser Glu Glu Val Ser His Ala Leu Lys Gln Ser Ile Arg Arg Gly
        195                 200                 205             
Leu Pro Arg Val Glu Ala Arg His Tyr Leu Ser Val Tyr Gln Asp Ile
    210                 215                 220                 
Glu Ser His Asn Lys Ala Leu Leu Glu Phe Ala Lys Ile Asp Phe Asn
225                 230                 235                 240 
Met Leu Gln Phe Leu His Arg Lys Glu Leu Ser Glu Ile Cys Arg Trp
                245                 250                 255     
Trp Lys Asp Leu Asp Phe Gln Arg Lys Leu Pro Tyr Ala Arg Asp Arg
            260                 265                 270         
Val Val Glu Gly Tyr Phe Trp Ile Ser Gly Val Tyr Phe Glu Pro Gln
        275                 280                 285             
Tyr Ser Leu Gly Arg Lys Met Leu Thr Lys Val Ile Ala Met Ala Ser
    290                 295                 300                 
Ile Val Asp Asp Thr Tyr Asp Ser Tyr Ala Thr Tyr Glu Glu Leu Ile
305                 310                 315                 320 
Pro Tyr Thr Asn Ala Ile Glu Arg Trp Asp Ile Lys Cys Ile Asp Glu
                325                 330                 335     
Ile Pro Glu Tyr Met Lys Pro Ser Tyr Lys Ala Leu Leu Asp Val Tyr
            340                 345                 350         
Glu Glu Met Val Gln Leu Val Ala Glu His Gly Arg Gln Tyr Arg Val
        355                 360                 365             
Glu Tyr Ala Lys Asn Ala Met Ile Arg Leu Ala Gln Ser Tyr Leu Val
    370                 375                 380                 
Glu Ala Lys Trp Thr Leu Gln Asn Tyr Lys Pro Ser Phe Glu Glu Phe
385                 390                 395                 400 
Lys Ala Asn Ala Leu Pro Thr Cys Gly Tyr Ala Met Leu Ala Ile Thr
                405                 410                 415     
Ser Phe Val Gly Met Gly Asp Ile Val Thr Pro Glu Thr Phe Lys Trp
            420                 425                 430         
Ala Ala Ser Asp Pro Lys Ile Ile Gln Ala Ser Thr Ile Ile Cys Arg
        435                 440                 445             
Phe Met Asp Asp Val Ala Glu His Lys Phe Lys His Arg Arg Glu Asp
    450                 455                 460                 
Asp Cys Ser Ala Ile Glu Cys Tyr Met Glu Glu Tyr Gly Val Thr Ala
465                 470                 475                 480 
Gln Glu Ala Tyr Asp Val Phe Asn Lys His Val Glu Ser Ala Trp Lys
                485                 490                 495     
Asp Leu Asn Gln Glu Phe Leu Lys Pro Thr Glu Met Pro Thr Glu Val
            500                 505                 510         
Leu Asn Arg Ser Leu Asn Leu Ala Arg Val Met Asp Val Leu Tyr Arg
        515                 520                 525             
Glu Gly Asp Gly Tyr Thr Tyr Val Gly Lys Ala Ala Lys Gly Gly Ile
    530                 535                 540                 
Thr Ser Leu Leu Ile Glu Pro Ile Ala Leu
545                 550                 


<210> 432
<211> 584
<212> PRT
<213> Ixeris dentate

<220> 
<223> germacrene A synthase Acc. No. AAL92481

<400> 432
Met Ala Leu Val Arg Asn Asn Ser Ile Asn Gly Arg Glu Pro Val Leu
 1               5                  10                  15      
Ser Pro Arg Ser Leu Thr Ser Pro Arg Gly Leu Thr Ser Pro Arg Pro
            20                  25                  30          
Leu Ala Val Gln Pro Thr Pro Glu Pro Val Arg Pro Leu Ala Asn Phe
        35                  40                  45              
Pro Pro Ser Ile Trp Ala Asn Arg Phe Ile Ser Phe Ser Leu Asp Asn
    50                  55                  60                  
Ser Glu Leu Glu Ala Tyr Ala Asn Ala His Glu Glu Pro Lys Glu Ser
65                  70                  75                  80  
Val Arg Ser Leu Ile Thr Asp Thr Thr Ile Asp Ala Ser Ala Lys Leu
                85                  90                  95      
Lys Leu Ile Tyr Ser Val His Arg Leu Gly Leu Ser Tyr Leu Tyr Pro
            100                 105                 110         
Glu Glu Ile Asp Ala Glu Leu Asp Gln Leu Phe Lys Lys Ile Asp Leu
        115                 120                 125             
His His Tyr Glu Gln Val Asp Leu Tyr Thr Ile Ser Val Gln Phe Gln
    130                 135                 140                 
Val Phe Arg His His Gly Tyr Lys Leu Ser Ser Asp Ile Phe Lys Lys
145                 150                 155                 160 
Phe Lys Asp Thr Thr Thr Gly Thr Phe Thr Asp Glu Val Thr Lys Asp
                165                 170                 175     
Val Lys Gly Met Leu Ser Leu Tyr Glu Ser Ala His Leu Arg Leu His
            180                 185                 190         
Gly Glu Glu Ile Leu Asp Glu Ala Leu Val Phe Thr Glu Ala Gln Leu
        195                 200                 205             
Lys Lys Ile Val Ser Thr Leu Glu Gly Asp Leu Ala Asn Gln Val Asn
    210                 215                 220                 
Gln Val Leu Lys Arg Pro Phe His Thr Gly Met Pro Met Val Glu Ala
225                 230                 235                 240 
Arg Leu Tyr Phe Asn Thr His Glu Glu Asp Val Ser Cys Tyr Glu Ser
                245                 250                 255     
Ile Val Lys Leu Ala Lys Val His Phe Asn Tyr Leu Gln Leu Gln Gln
            260                 265                 270         
Lys Glu Glu Leu Arg Ile Val Ser Gln Trp Trp Lys Asp Met Glu Phe
        275                 280                 285             
Gln Thr Ser Val Pro Tyr Ile Arg Asp Arg Val Pro Glu Ile Tyr Leu
    290                 295                 300                 
Trp Ile Leu Gly Leu Tyr Phe Glu Pro Tyr Tyr Ser Arg Ala Arg Ile
305                 310                 315                 320 
Ile Ala Thr Lys Ile Thr Leu Phe Leu Val Val Leu Asp Asp Thr Tyr
                325                 330                 335     
Asp Ala Tyr Ala Thr Ile Asp Glu Ile Arg Ala Ile Thr Asp Ala Ile
            340                 345                 350         
Asn Arg Trp Glu Met Ser Ala Ile Asp Leu Leu Pro Glu Tyr Ile Lys
        355                 360                 365             
Pro Phe Tyr Arg Ile Leu Leu Asn Glu Tyr Asp Asp Leu Glu Lys Glu
    370                 375                 380                 
Tyr Ser Lys Asp Gly Arg Ala Phe Ser Val His Ala Ser Lys Gln Ala
385                 390                 395                 400 
Phe Gln Glu Ile Ala Arg Gly Tyr Leu Glu Glu Ala Glu Trp Leu His
                405                 410                 415     
Asn Gly Tyr Val Ala Thr Phe Pro Glu Tyr Met Lys Asn Gly Leu Ile
            420                 425                 430         
Thr Ser Ala Tyr Asn Val Ile Ser Lys Ser Ala Leu Val Gly Met Gly
        435                 440                 445             
Ala Ile Ala Asp Glu Glu Ala Leu Ala Trp Tyr Glu Thr His Pro Lys
    450                 455                 460                 
Ile Leu Lys Ala Ser Glu Leu Ile Ser Arg Leu Gln Asp Asp Val Met
465                 470                 475                 480 
Thr Phe Gln Phe Glu Arg Lys Arg Gly Gln Ser Ala Thr Gly Val Asp
                485                 490                 495     
Ala Tyr Ile Lys Glu Tyr Asn Val Ser Glu Glu Val Ala Ile Lys Asp
            500                 505                 510         
Leu Met Lys Met Ile Glu Asn Ala Trp Lys Asp Ile Asn Glu Gly Cys
        515                 520                 525             
Leu Lys Pro Thr Glu Val Ser Val Ala Leu Leu Thr Pro Ile Leu Asn
    530                 535                 540                 
Leu Ala Arg Met Ile Asp Val Val Tyr Lys Phe Asp Asp Gly Phe Thr
545                 550                 555                 560 
Phe Pro Gly Lys Thr Leu Lys Asp Tyr Ile Thr Leu Leu Phe Val Thr
                565                 570                 575     
Pro Ala Pro Ser Leu Glu Ser Cys
            580                 


<210> 433
<211> 799
<212> PRT
<213> Lactuca sativa

<220> 
<223> copalyldiphosphate synthase No. 1 Acc. No.
      BAB12440

<400> 433
Met Lys Thr Met Ile Ser Ser Pro Ile Pro Ala Phe His Pro Arg Phe
 1               5                  10                  15      
Ser Pro Ala Ala Gly Ser Arg Arg Leu Ser Pro Ile Leu Pro Ser Ser
            20                  25                  30          
Gly Ser Val Val Leu Thr Gly Ser Lys Thr Gln Cys Lys Ala Val Ser
        35                  40                  45              
Lys Ser Pro Thr Gln Glu Tyr Phe Asp Val Leu Gln Lys Asn Gly Leu
    50                  55                  60                  
Pro Phe Ile Asn Trp Gln Asn Asp Val Val Glu Asp Glu Leu Asp Lys
65                  70                  75                  80  
Glu Lys Lys Ile Leu Tyr Pro Asn Asp Glu Ile Lys Gly Phe Val Glu
                85                  90                  95      
Arg Ile Lys Val Met Leu Gly Ser Met Asp Glu Gly Glu Ile Thr Val
            100                 105                 110         
Ser Ala Tyr Asp Thr Ala Trp Val Ala Leu Val Gln Asp Ile Asp Gly
        115                 120                 125             
Asn Gly Arg Pro Glu Phe Pro Ser Ser Leu Glu Trp Ile Val Lys Asn
    130                 135                 140                 
Gln Leu Ser Asp Gly Ser Trp Gly Asp His Leu Ile Phe Ser Ala His
145                 150                 155                 160 
Asp Arg Ile Ile Asn Thr Leu Ala Cys Val Ile Ala Leu Thr Ser Trp
                165                 170                 175     
Asn Val His Pro Gly Lys Cys Gln Lys Gly Leu Lys Phe Leu Asn Asp
            180                 185                 190         
Asn Ile Ser Lys Leu Glu Glu Glu Asn Pro Glu His Met Pro Ile Gly
        195                 200                 205             
Phe Glu Val Ala Phe Pro Ser Leu Ile Asp Ile Ala Arg Lys Leu Asp
    210                 215                 220                 
Ile Gln Val Pro Glu Asp Ser Pro Ala Leu Lys Glu Ile Tyr Ala Arg
225                 230                 235                 240 
Arg Asn Leu Lys Leu Thr Lys Ile Pro Lys Ser Leu Met His Lys Val
                245                 250                 255     
Pro Thr Thr Leu Leu His Ser Leu Glu Gly Met Pro Asp Leu Glu Trp
            260                 265                 270         
Glu Lys Leu Leu Lys Leu Gln Cys Lys Asp Gly Ser Phe Leu Phe Ser
        275                 280                 285             
Pro Ser Ser Thr Ala Phe Ala Leu Met Gln Thr Lys Asp Gln Lys Cys
    290                 295                 300                 
Leu Gln Tyr Leu Thr Asp Ala Val Thr Lys Phe Asn Gly Gly Val Pro
305                 310                 315                 320 
Asn Val Tyr Pro Val Asp Leu Phe Glu His Ile Trp Val Val Asp Arg
                325                 330                 335     
Leu Gln Arg Leu Gly Ile Ser Arg Tyr Phe Asp Ser Glu Ile Lys Asp
            340                 345                 350         
Cys Val Asp Tyr Ile Tyr Arg Tyr Trp Thr Lys Asp Gly Ile Cys Trp
        355                 360                 365             
Ala Lys Asn Ser Asn Val Gln Asp Ile Asp Asp Thr Ala Met Gly Phe
    370                 375                 380                 
Arg Val Leu Arg Met His Gly Tyr Lys Val Thr Thr Asp Val Phe Arg
385                 390                 395                 400 
Gln Phe Glu Lys Asp Gly Lys Phe Val Cys Phe Pro Gly Gln Thr Thr
                405                 410                 415     
Gln Ala Val Thr Gly Met Phe Asn Leu Phe Arg Ala Ser Gln Val Leu
            420                 425                 430         
Phe Pro Asp Glu Lys Ile Leu Glu Asp Ala Lys Lys Phe Ser Tyr Asn
        435                 440                 445             
Tyr Leu Lys Glu Lys Gln Ser Thr Asn Glu Leu Leu Asp Lys Trp Ile
    450                 455                 460                 
Ile Ala Lys Asp Leu Pro Gly Glu Val Glu Tyr Ala Leu Asp Val Pro
465                 470                 475                 480 
Trp Tyr Ala Ser Leu Pro Arg Leu Glu Thr Arg Phe Tyr Leu Glu Gln
                485                 490                 495     
Tyr Gly Gly Glu Asp Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met
            500                 505                 510         
Gly Asn Val Ser Asn Asn Thr Tyr Leu Glu Met Ala Lys Leu Asp Tyr
        515                 520                 525             
Asn Asn Cys Leu Ala Ile His His Leu Glu Trp Asn Thr Met Gln Gln
    530                 535                 540                 
Trp Tyr Val Asp Phe Gly Met Glu Arg Phe Gly Thr Ser Asp Ile Thr
545                 550                 555                 560 
Ser Leu Leu Val Ser Tyr Tyr Leu Ala Ala Ala Ser Val Phe Glu Pro
                565                 570                 575     
Glu Arg Ser Lys Glu Arg Ile Ala Trp Ala Lys Thr Thr Thr Leu Val
            580                 585                 590         
Asp Thr Ile Ser Ser Phe Phe His Ser Leu Lys Ile Ser Asn Glu His
        595                 600                 605             
Arg Arg Glu Phe Val Glu Glu Phe Arg Asn Ile Ser Asn Ser Ile His
    610                 615                 620                 
His Ala Lys Tyr Gly Lys Pro Trp His Gly Leu Met Val Ala Leu Lys
625                 630                 635                 640 
Gly Thr Leu His Glu Ile Ala Leu Asp Val Leu Met Thr His Arg Arg
                645                 650                 655     
Asp Ile His Pro Gln Leu His His Ala Trp Glu Met Trp Leu Met Arg
            660                 665                 670         
Trp Gln Gln Gly Val Asp Ala Thr Glu Gly Gln Ala Glu Leu Ile Val
        675                 680                 685             
Gln Thr Ile Asn Met Thr Ala Gly Arg Trp Val Ser Asn Glu Leu Leu
    690                 695                 700                 
Ala His Pro Gln Tyr Arg Leu Leu Ser Ser Val Ile Asn Asn Ile Cys
705                 710                 715                 720 
His Glu Ile Tyr His Asn Arg Thr Cys Met Glu Val Asn Ser Thr Thr
                725                 730                 735     
Ile Ser Thr Ser Ile Asp Ser Lys Met Gln Glu Leu Val Gln Leu Val
            740                 745                 750         
Leu Ser Asp Ser Leu Asp Asp Leu Asp Gln Asp Leu Lys Gln Thr Phe
        755                 760                 765             
Leu Thr Val Ala Lys Thr Phe Tyr Tyr Lys Ala Tyr Cys Asp Pro Glu
    770                 775                 780                 
Thr Ile Asn Val His Ile Ser Lys Val Met Phe Glu Thr Ile Ile
785                 790                 795                 


<210> 434
<211> 559
<212> PRT
<213> Lactuca sativa

<220> 
<223> germacrene A synthase LTC1 Acc. No. AAM11626

<400> 434
Met Ala Ala Val Glu Ala Asn Gly Thr Leu Gln Ala Asn Thr Lys Thr
 1               5                  10                  15      
Thr Thr Glu Pro Val Arg Pro Leu Ala Asn Phe Pro Pro Ser Val Trp
            20                  25                  30          
Gly Asp Arg Phe Leu Ser Phe Ser Leu Asp Asn Thr Glu Leu Glu Gly
        35                  40                  45              
Tyr Ala Lys Ala Met Glu Glu Pro Lys Glu Glu Val Arg Arg Leu Ile
    50                  55                  60                  
Val Asp Pro Thr Met Asp Ser Asn Lys Lys Leu Ser Leu Ile Tyr Ser
65                  70                  75                  80  
Val His Arg Leu Gly Leu Thr Tyr Leu Phe Leu Gln Glu Ile Glu Ala
                85                  90                  95      
Gln Leu Asp Asn Ile Phe Lys Ala Phe Lys Leu Gln Asp Tyr Asp Glu
            100                 105                 110         
Val Asp Leu Tyr Thr Thr Ser Ile Asn Phe Gln Val Phe Arg His Leu
        115                 120                 125             
Gly His Lys Leu Pro Cys Asp Val Phe Asn Lys Phe Lys Asp Ser Ser
    130                 135                 140                 
Ser Gly Thr Phe Lys Glu Ser Ile Thr Asn Asp Val Lys Gly Met Leu
145                 150                 155                 160 
Gly Leu Tyr Glu Cys Ala Gln Leu Arg Leu Arg Gly Glu Ser Ile Leu
                165                 170                 175     
Asp Glu Ala Ser Ala Phe Thr Val Thr Gln Leu Lys Ser Val Val Asn
            180                 185                 190         
Thr Leu Glu Gly Lys Leu Ala Gln Gln Val Leu Gln Ser Leu Lys Arg
        195                 200                 205             
Pro Phe His Gln Gly Met Pro Met Val Glu Ala Arg Phe Tyr Phe Ser
    210                 215                 220                 
Asn Tyr Asp Glu Glu Cys Ser Thr His Glu Ser Leu Val Lys Leu Ala
225                 230                 235                 240 
Lys Leu His Phe Asn Tyr Leu Gln Leu Gln Gln Lys Glu Glu Leu Arg
                245                 250                 255     
Ile Val Ser Lys Trp Trp Lys Asp Met Arg Phe Gln Glu Thr Thr Pro
            260                 265                 270         
Tyr Ile Arg Asp Arg Val Pro Glu Ile Tyr Leu Trp Ile Leu Gly Leu
        275                 280                 285             
Tyr Phe Glu Pro Arg Tyr Ser Leu Ala Arg Ile Ile Ala Thr Lys Ile
    290                 295                 300                 
Thr Leu Phe Leu Val Val Leu Asp Asp Thr Tyr Asp Ala Tyr Ala Thr
305                 310                 315                 320 
Ile Glu Glu Ile Arg Leu Leu Thr Asp Ala Ile Asn Arg Trp Asp Ile
                325                 330                 335     
Ser Ala Ile Glu Gln Ile Pro Glu Tyr Ile Arg Pro Phe Tyr Lys Ile
            340                 345                 350         
Leu Leu Asp Glu Tyr Ala Glu Leu Glu Lys Gln Leu Ala Lys Glu Gly
        355                 360                 365             
Arg Ala Lys Ser Val Ile Ala Leu Lys Glu Ala Phe Gln Asp Ile Ala
    370                 375                 380                 
Arg Gly Tyr Leu Glu Glu Ala Glu Trp Thr Asn Ser Gly Tyr Val Ala
385                 390                 395                 400 
Ser Phe Pro Glu Tyr Met Lys Asn Gly Leu Val Thr Ser Ala Tyr Asn
                405                 410                 415     
Val Ile Ser Lys Ser Ala Leu Val Gly Met Gly Glu Met Val Ser Glu
            420                 425                 430         
Asp Ala Leu Ala Trp Tyr Glu Ser His Pro Lys Thr Leu Gln Ala Ser
        435                 440                 445             
Glu Leu Ile Ser Arg Leu Gln Asp Asp Val Met Thr Tyr Gln Phe Glu
    450                 455                 460                 
Arg Glu Arg Gly Gln Ser Ala Thr Gly Val Asp Ser Tyr Ile Lys Thr
465                 470                 475                 480 
Tyr Gly Val Ser Glu Lys Glu Ala Ile Asp Glu Leu Asn Lys Met Ile
                485                 490                 495     
Glu Asn Ala Trp Lys Asp Ile Asn Glu Gly Cys Leu Lys Pro Arg Glu
            500                 505                 510         
Val Ser Met Asp Leu Leu Ala Pro Ile Leu Asn Leu Ala Arg Met Ile
        515                 520                 525             
Asp Val Val Tyr Arg Tyr Asp Asp Gly Phe Thr Phe Pro Gly Lys Thr
    530                 535                 540                 
Met Lys Glu Tyr Ile Thr Leu Leu Phe Val Gly Ser Ser Pro Met
545                 550                 555                 


<210> 435
<211> 557
<212> PRT
<213> Lactuca sativa

<220> 
<223> germacrene A synthase LTC2 Acc. No. AAM11627

<400> 435
Met Ala Ala Val Asp Thr Asn Ala Thr Ile Gln Glu Lys Thr Thr Ala
 1               5                  10                  15      
Glu Pro Val Arg Pro Leu Ala Asn Phe Pro Pro Ser Val Trp Gly Asp
            20                  25                  30          
Arg Phe Leu Ser Phe Thr Leu Asp Asn Ser Glu Leu Glu Gly Tyr Ala
        35                  40                  45              
Lys Ala Met Glu Ala Pro Lys Glu Glu Leu Arg Arg Leu Ile Val Asp
    50                  55                  60                  
Gln Thr Met Asp Ser Asn Lys Lys Leu Ser Leu Ile Tyr Ser Val His
65                  70                  75                  80  
Arg Leu Gly Leu Thr Tyr Leu Phe Leu Gln Glu Ile Glu Ala Gln Leu
                85                  90                  95      
Asp Lys Ile Phe Lys Glu Phe Asn Leu Gln Asn Tyr Asp Glu Val Asp
            100                 105                 110         
Leu Tyr Thr Thr Ser Ile Asn Phe Gln Val Phe Arg His Leu Gly Tyr
        115                 120                 125             
Lys Leu Pro Cys Asp Val Phe Asn Lys Phe Lys Asp Asn Thr Ser Gly
    130                 135                 140                 
Ala Phe Lys Glu Asp Ile Ser Thr Asp Val Lys Gly Met Leu Gly Leu
145                 150                 155                 160 
Tyr Glu Ser Ser Gln Leu Arg Thr Arg Gly Glu Ser Ile Leu Asp Glu
                165                 170                 175     
Ala Ser Ser Phe Thr Glu Thr Lys Leu Lys Ser Val Val Asn Asn Leu
            180                 185                 190         
Glu Gly Asn Leu Ala Gln Gln Val Leu Gln Ser Leu Arg Arg Pro Phe
        195                 200                 205             
His Gln Gly Met Pro Met Val Glu Ala Arg Leu Tyr Phe Ser Asn Tyr
    210                 215                 220                 
Ser Glu Glu Cys Ala Thr His Glu Cys Leu Leu Lys Leu Ala Lys Leu
225                 230                 235                 240 
His Phe Ser Tyr Leu Glu Leu Gln Gln Lys Glu Glu Leu Arg Ile Val
                245                 250                 255     
Ser Lys Trp Trp Lys Asp Met Arg Phe Gln Glu Thr Thr Pro Tyr Ile
            260                 265                 270         
Arg Asp Arg Val Pro Glu Ile Tyr Leu Trp Ile Leu Gly Leu Tyr Phe
        275                 280                 285             
Glu Pro Arg Tyr Ser Leu Ala Arg Ile Ile Ala Thr Lys Ile Thr Leu
    290                 295                 300                 
Phe Leu Val Val Leu Asp Asp Thr Tyr Asp Ala Tyr Ala Thr Ile Glu
305                 310                 315                 320 
Glu Ile Arg Leu Leu Thr Asp Ala Ile Asn Arg Trp Asp Met Ser Ala
                325                 330                 335     
Met Glu Gln Ile Pro Glu Tyr Ile Arg Pro Phe Tyr Lys Ile Leu Leu
            340                 345                 350         
Asp Glu Tyr Ala Glu Leu Glu Lys Gln Leu Ala Ile Glu Gly Arg Ala
        355                 360                 365             
Lys Ser Val Ile Ala Ser Lys Glu Ala Phe Gln Asp Ile Ala Arg Gly
    370                 375                 380                 
Tyr Leu Glu Glu Ala Glu Trp Thr Asn Ser Gly Tyr Val Ala Ser Phe
385                 390                 395                 400 
Pro Glu Tyr Met Lys Asn Gly Leu Ile Thr Ser Ala Tyr Asn Val Ile
                405                 410                 415     
Ser Lys Ser Ala Leu Val Gly Met Gly Asp Ile Val Ser Glu Asn Ala
            420                 425                 430         
Leu Ala Trp Tyr Glu Ser His Pro Lys Thr Leu Gln Ala Ser Glu Leu
        435                 440                 445             
Ile Ser Arg Leu Gln Asp Asp Val Met Thr Tyr Gln Phe Glu Arg Glu
    450                 455                 460                 
Arg Gly Gln Ser Ala Thr Gly Val Asp Ala Tyr Ile Lys Thr Tyr Gly
465                 470                 475                 480 
Val Ser Glu Lys Glu Ala Ile Asp Glu Leu Lys Ile Met Ile Glu Asn
                485                 490                 495     
Ala Trp Lys Asp Ile Asn Glu Gly Cys Leu Lys Pro Arg Glu Val Ser
            500                 505                 510         
Met Asp Leu Leu Ala Pro Ile Leu Asn Leu Ala Arg Met Ile Asp Val
        515                 520                 525             
Val Tyr Arg Tyr Asp Asp Gly Phe Thr Phe Pro Gly Lys Thr Met Lys
    530                 535                 540                 
Glu Tyr Ile Thr Leu Leu Phe Val Gly Ser Val Ser Met
545                 550                 555         


<210> 436
<211> 538
<212> PRT
<213> Lavandula angusivolia

<220> 
<223> (E)-alpha-bergamotene synthase Acc. No. ABB73046

<400> 436
Met Glu Ala Arg Arg Ser Gly Asn Phe Glu Ser Ser Ile Trp Asp Asp
 1               5                  10                  15      
Asp Tyr Ile Gln Ser Leu Thr Ser Ser Tyr Thr Gly Lys Met Tyr Val
            20                  25                  30          
Asp Lys Ser Glu Lys Leu Lys Ile Glu Val Lys Met Met Met Asp Glu
        35                  40                  45              
Ala Thr Asp Glu Leu Glu Gln Leu Glu Leu Ile Asn Asp Leu Gln Arg
    50                  55                  60                  
Leu Gly Ile Ser Tyr His Phe Lys Asp Gly Ile Ala Lys Met Leu Asn
65                  70                  75                  80  
Asn Ile Tyr Lys Ser Asp Ser Lys Tyr Met Glu Lys Asp Leu His Leu
                85                  90                  95      
Thr Ala Leu Lys Phe Arg Leu Leu Arg Gln His Gly Tyr Arg Val Pro
            100                 105                 110         
Gln Asp Val Phe Ser Ser Phe Met Asp Asp Glu Gly Asn Phe Glu Ala
        115                 120                 125             
Trp Val Val Glu Asp Val Ser Val Leu Val Ser Leu Tyr Glu Ala Ser
    130                 135                 140                 
His Ile Ser Val Glu Gly Glu Ser Ile Leu Asp Met Ala Lys Asp Phe
145                 150                 155                 160 
Ser Ser His His Leu Thr Glu Met Val Glu Gln Ile Gly Glu Ala Cys
                165                 170                 175     
Leu Ala Glu Gln Val Lys Arg Thr Leu Glu Leu Pro Leu His Trp Arg
            180                 185                 190         
Val Gly Arg Leu Glu Ala Arg Trp Phe Val Gln Ala Tyr Glu Thr Arg
        195                 200                 205             
Pro Asn Ser Asn Pro Thr Leu Val Glu Leu Ala Lys Leu Asp Phe Asn
    210                 215                 220                 
Met Val Gln Ala Lys Tyr Gln Asp Glu Leu Lys Arg Cys Ser Arg Trp
225                 230                 235                 240 
Tyr Glu Glu Thr Gly Leu Pro Glu Lys Met Ser Phe Ala Arg His Arg
                245                 250                 255     
Leu Ala Glu Cys Phe Leu Trp Ser Leu Gly Phe Ile Pro Asp Pro His
            260                 265                 270         
His Gly Tyr Ser Arg Glu Ile Met Thr Lys Ile Ala Val Leu Ile Thr
        275                 280                 285             
Ile Thr Asp Asp Ile Tyr Asp Ile Tyr Gly Ala Leu Glu Glu Leu Gln
    290                 295                 300                 
Glu Phe Thr Glu Ala Phe Glu Arg Trp Asp Ile Asn Ser Leu Asp Leu
305                 310                 315                 320 
Leu Pro Glu Tyr Met Gln Ile Cys Phe Leu Ala Ile Phe Asn Ser Ala
                325                 330                 335     
Asn Glu Leu Gly Tyr Gln Ile Leu Arg Asp Gln Gly Leu Asn Ile Ile
            340                 345                 350         
Pro Asn Leu Lys Arg Ser Trp Ala Glu Leu Ser Arg Ala Tyr Tyr Leu
        355                 360                 365             
Glu Ala Arg Trp Phe His Asn Gly Phe Val Pro Thr Thr Asp Gln Tyr
    370                 375                 380                 
Leu Asn Thr Ala Trp Ile Ser Ile Ser Gly Pro Leu Leu Leu Ser Tyr
385                 390                 395                 400 
Gly Tyr Leu Thr Thr Thr Asn Pro Ile Asn Asn Lys Glu Leu Lys Ser
                405                 410                 415     
Leu Glu Lys His Pro Ser Ile Ile Arg Trp Pro Ser Met Val Leu Arg
            420                 425                 430         
Leu Ala Asp Asp Leu Gly Thr Ser Ser Glu Glu Ile Lys Arg Gly Asp
        435                 440                 445             
Val Ser Lys Ser Ile Gln Cys Tyr Met Asn Glu Thr Gly Cys Cys Glu
    450                 455                 460                 
Gly Asp Ala Arg His His Val Lys Ser Leu Ile Glu Val Ala Leu Lys
465                 470                 475                 480 
Arg Met Asn Asp Glu Ile Leu Met Glu Lys Pro Phe Lys Ser Phe Asp
                485                 490                 495     
Thr Asn Ala Met Asn Leu Ala Arg Ile Ser Leu Cys Phe Tyr Gln Tyr
            500                 505                 510         
Gly Asp Gly Phe Gly Lys Pro His Ser Asp Thr Ile Lys Asn Leu Val
        515                 520                 525             
Ser Leu Ile Val Leu Pro Phe His Met Pro
    530                 535             


<210> 437
<211> 548
<212> PRT
<213> Lycopersicon esculentum

<220> 
<223> germacrene C synthase Acc. No. AAC39432

<400> 437
Met Ala Ala Ser Ser Ala Asp Lys Cys Arg Pro Leu Ala Asn Phe His
 1               5                  10                  15      
Pro Ser Val Trp Gly Tyr His Phe Leu Ser Tyr Thr His Glu Ile Thr
            20                  25                  30          
Asn Gln Glu Lys Val Glu Val Asp Glu Tyr Lys Glu Thr Ile Arg Lys
        35                  40                  45              
Met Leu Val Glu Thr Cys Asp Asn Ser Thr Gln Lys Leu Val Leu Ile
    50                  55                  60                  
Asp Ala Met Gln Arg Leu Gly Val Ala Tyr His Phe Asp Asn Glu Ile
65                  70                  75                  80  
Glu Thr Ser Ile Gln Asn Ile Phe Asp Ala Ser Ser Lys Gln Asn Asp
                85                  90                  95      
Asn Asp Asn Asn Leu Tyr Val Val Ser Leu Arg Phe Arg Leu Val Arg
            100                 105                 110         
Gln Gln Gly His Tyr Met Ser Ser Asp Val Phe Lys Gln Phe Thr Asn
        115                 120                 125             
Gln Asp Gly Lys Phe Lys Glu Thr Leu Thr Asn Asp Val Gln Gly Leu
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ser His Leu Arg Val Arg Asn Glu Glu Ile
145                 150                 155                 160 
Leu Glu Glu Ala Leu Thr Phe Thr Thr Thr His Leu Glu Ser Ile Val
                165                 170                 175     
Ser Asn Leu Ser Asn Asn Asn Asn Ser Leu Lys Val Glu Val Gly Glu
            180                 185                 190         
Ala Leu Thr Gln Pro Ile Arg Met Thr Leu Pro Arg Met Gly Ala Arg
        195                 200                 205             
Lys Tyr Ile Ser Ile Tyr Glu Asn Asn Asp Ala His His His Leu Leu
    210                 215                 220                 
Leu Lys Phe Ala Lys Leu Asp Phe Asn Met Leu Gln Lys Phe His Gln
225                 230                 235                 240 
Arg Glu Leu Ser Asp Leu Thr Arg Trp Trp Lys Asp Leu Asp Phe Ala
                245                 250                 255     
Asn Lys Tyr Pro Tyr Ala Arg Asp Arg Leu Val Glu Cys Tyr Phe Trp
            260                 265                 270         
Ile Leu Gly Val Tyr Phe Glu Pro Lys Tyr Ser Arg Ala Arg Lys Met
        275                 280                 285             
Met Thr Lys Val Leu Asn Leu Thr Ser Ile Ile Asp Asp Thr Phe Asp
    290                 295                 300                 
Ala Tyr Ala Thr Phe Asp Glu Leu Val Thr Phe Asn Asp Ala Ile Gln
305                 310                 315                 320 
Arg Trp Asp Ala Asn Ala Ile Asp Ser Ile Gln Pro Tyr Met Arg Pro
                325                 330                 335     
Ala Tyr Gln Ala Leu Leu Asp Ile Tyr Ser Glu Met Glu Gln Val Leu
            340                 345                 350         
Ser Lys Glu Gly Lys Leu Asp Arg Val Tyr Tyr Ala Lys Asn Glu Met
        355                 360                 365             
Lys Lys Leu Val Arg Ala Tyr Phe Lys Glu Thr Gln Trp Leu Asn Asp
    370                 375                 380                 
Cys Asp His Ile Pro Lys Tyr Glu Glu Gln Val Glu Asn Ala Ile Val
385                 390                 395                 400 
Ser Ala Gly Tyr Met Met Ile Ser Thr Thr Cys Leu Val Gly Ile Glu
                405                 410                 415     
Glu Phe Ile Ser His Glu Thr Phe Glu Trp Leu Met Asn Glu Ser Val
            420                 425                 430         
Ile Val Arg Ala Ser Ala Leu Ile Ala Arg Ala Met Asn Asp Ile Val
        435                 440                 445             
Gly His Glu Asp Glu Gln Glu Arg Gly His Val Ala Ser Leu Ile Glu
    450                 455                 460                 
Cys Tyr Met Lys Asp Tyr Gly Ala Ser Lys Gln Glu Thr Tyr Ile Lys
465                 470                 475                 480 
Phe Leu Lys Glu Val Thr Asn Ala Trp Lys Asp Ile Asn Lys Gln Phe
                485                 490                 495     
Ser Arg Pro Thr Glu Val Pro Met Phe Val Leu Glu Arg Val Leu Asn
            500                 505                 510         
Leu Thr Arg Val Ala Asp Thr Leu Tyr Lys Glu Lys Asp Thr Tyr Ser
        515                 520                 525             
Thr Ala Lys Gly Lys Leu Lys Asn Met Ile Asn Pro Ile Leu Ile Glu
    530                 535                 540                 
Ser Val Lys Ile
545             


<210> 438
<211> 548
<212> PRT
<213> Lycopersicon esculentum

<220> 
<223> beta-elemene synthase Acc. No. AAG41889

<400> 438
Met Ala Ala Ser Ser Ala Asp Lys Cys Arg Pro Leu Ala Asn Phe His
 1               5                  10                  15      
Pro Ser Val Trp Gly Tyr His Phe Leu Ser Tyr Thr His Glu Ile Thr
            20                  25                  30          
Asn Gln Glu Lys Val Glu Val Asp Glu Tyr Lys Glu Thr Ile Arg Lys
        35                  40                  45              
Met Leu Val Glu Thr Cys Asp Asn Ser Thr Gln Lys Leu Val Leu Ile
    50                  55                  60                  
Asp Ala Met Gln Arg Leu Gly Val Ala Tyr His Phe Asp Asn Glu Ile
65                  70                  75                  80  
Glu Thr Ser Ile Gln Asn Ile Phe Asp Ala Ser Ser Lys Gln Asn Asp
                85                  90                  95      
Asn Asp Asn Asn Leu Tyr Val Val Ser Leu Arg Phe Arg Leu Val Arg
            100                 105                 110         
Gln Gln Gly His Tyr Met Ser Ser Asp Val Phe Lys Gln Phe Thr Asn
        115                 120                 125             
Gln Asp Gly Lys Phe Lys Glu Thr Leu Thr Asn Asp Val Gln Gly Leu
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ser His Leu Arg Val Arg Asn Glu Glu Ile
145                 150                 155                 160 
Leu Glu Glu Ala Leu Thr Phe Thr Thr Thr His Leu Glu Ser Ile Val
                165                 170                 175     
Ser Asn Leu Ser Asn Asn Asn Asn Ser Leu Lys Val Glu Val Gly Glu
            180                 185                 190         
Ala Leu Thr Gln Pro Ile Arg Met Thr Leu Pro Arg Met Gly Ala Arg
        195                 200                 205             
Lys Tyr Ile Ser Ile Tyr Glu Asn Asn Asp Ala His His His Leu Leu
    210                 215                 220                 
Leu Lys Phe Ala Lys Leu Asp Phe Asn Met Leu Gln Lys Phe His Gln
225                 230                 235                 240 
Arg Glu Leu Ser Asp Leu Thr Arg Trp Trp Lys Asp Leu Asp Phe Ala
                245                 250                 255     
Asn Lys Tyr Pro Tyr Ala Arg Asp Arg Leu Val Glu Cys Tyr Phe Trp
            260                 265                 270         
Ile Leu Gly Val Tyr Phe Glu Pro Lys Tyr Ser Arg Ala Arg Lys Met
        275                 280                 285             
Met Thr Lys Val Leu Asn Leu Thr Ser Ile Ile Asp Asp Thr Phe Asp
    290                 295                 300                 
Ala Tyr Ala Thr Phe Asp Glu Leu Val Thr Phe Asn Asp Ala Ile Gln
305                 310                 315                 320 
Arg Trp Asp Ala Asn Ala Ile Asp Ser Ile Gln Pro Tyr Met Arg Pro
                325                 330                 335     
Ala Tyr Gln Ala Leu Leu Asp Ile Tyr Ser Glu Met Glu Gln Val Leu
            340                 345                 350         
Ser Lys Glu Gly Lys Leu Asp Arg Val Tyr Tyr Ala Lys Asn Glu Met
        355                 360                 365             
Lys Lys Leu Val Arg Ala Tyr Phe Lys Glu Thr Gln Trp Leu Asn Asp
    370                 375                 380                 
Cys Asp His Ile Pro Lys Tyr Glu Glu Gln Val Glu Asn Ala Ile Val
385                 390                 395                 400 
Ser Ala Gly Tyr Met Met Ile Ser Thr Thr Cys Leu Val Gly Ile Glu
                405                 410                 415     
Glu Phe Ile Ser His Glu Thr Phe Glu Trp Leu Met Asn Glu Ser Val
            420                 425                 430         
Ile Val Arg Ala Ser Ala Leu Ile Ala Arg Ala Met Asn Asp Ile Val
        435                 440                 445             
Gly His Glu Asp Glu Gln Glu Arg Gly His Val Ala Ser Leu Ile Glu
    450                 455                 460                 
Cys Tyr Met Lys Asp Tyr Gly Ala Ser Lys Gln Glu Thr Tyr Ile Lys
465                 470                 475                 480 
Phe Leu Lys Glu Val Thr Asn Ala Trp Lys Asp Ile Asn Lys Gln Phe
                485                 490                 495     
Phe Arg Pro Thr Glu Val Pro Met Phe Val Leu Glu Arg Val Leu Asn
            500                 505                 510         
Leu Thr Arg Val Ala Asp Thr Leu Tyr Lys Glu Lys Asp Thr Tyr Thr
        515                 520                 525             
Asn Ala Lys Gly Lys Leu Lys Asn Met Ile Asn Ser Ile Leu Ile Glu
    530                 535                 540                 
Ser Val Lys Ile
545             


<210> 439
<211> 552
<212> PRT
<213> Lycopersicon esculentum

<220> 
<223> beta-elemene synthase Acc. No. AAG41890

<400> 439
Leu Val Pro Asn Ser Ala Arg Ala Ser Ala Asp Lys Cys Arg Pro Leu
 1               5                  10                  15      
Ala Asn Phe His Pro Ser Val Trp Gly Tyr His Phe Leu Ser Tyr Thr
            20                  25                  30          
His Glu Ile Thr Asn Gln Glu Lys Val Glu Val Asp Glu Tyr Lys Glu
        35                  40                  45              
Thr Ile Arg Lys Met Leu Val Glu Thr Cys Asp Asn Ser Thr Gln Lys
    50                  55                  60                  
Leu Val Leu Ile Asp Ala Met Gln Arg Leu Gly Val Ala Tyr His Phe
65                  70                  75                  80  
Asp Asn Glu Ile Glu Thr Ser Ile Gln Asn Ile Phe Asp Ala Ser Ser
                85                  90                  95      
Lys Gln Asn Asp Asn Asp Asn Asn Leu Tyr Val Val Ser Leu Arg Phe
            100                 105                 110         
Arg Leu Val Arg Gln Gln Gly His Tyr Met Ser Ser Asp Val Phe Lys
        115                 120                 125             
Gln Phe Thr Asn Gln Asp Gly Lys Phe Lys Glu Thr Leu Thr Asn Asp
    130                 135                 140                 
Val Gln Gly Leu Leu Ser Leu Tyr Glu Ala Ser His Leu Arg Val Arg
145                 150                 155                 160 
Asn Glu Glu Ile Leu Glu Glu Ala Leu Thr Phe Thr Thr Thr His Leu
                165                 170                 175     
Glu Ser Ile Val Ser Asn Leu Ser Asn Asn Asn Asn Ser Leu Lys Val
            180                 185                 190         
Glu Val Gly Glu Ala Leu Thr Gln Pro Ile Arg Met Thr Leu Pro Arg
        195                 200                 205             
Met Gly Ala Arg Lys Tyr Ile Ser Ile Tyr Glu Asn Asn Asp Ala His
    210                 215                 220                 
His His Leu Leu Leu Lys Phe Ala Lys Leu Asp Phe Asn Met Leu Gln
225                 230                 235                 240 
Lys Phe His Gln Arg Glu Leu Ser Asp Leu Thr Arg Trp Trp Lys Asp
                245                 250                 255     
Leu Asp Phe Ala Asn Lys Tyr Pro Tyr Ala Arg Asp Arg Leu Val Glu
            260                 265                 270         
Cys Tyr Phe Trp Ile Leu Gly Val Tyr Phe Glu Pro Lys Tyr Ser Arg
        275                 280                 285             
Ala Arg Lys Met Met Thr Lys Val Leu Asn Leu Thr Ser Ile Ile Asp
    290                 295                 300                 
Asp Thr Phe Asp Ala Tyr Ala Thr Phe Asp Glu Leu Val Thr Phe Asn
305                 310                 315                 320 
Asp Ala Ile Gln Arg Trp Asp Ala Asn Ala Ile Asp Ser Ile Gln Pro
                325                 330                 335     
Tyr Met Arg Pro Ala Tyr Gln Ala Leu Leu Asp Ile Tyr Ser Glu Met
            340                 345                 350         
Glu Gln Val Leu Ser Lys Glu Gly Lys Leu Asp Arg Val Tyr Tyr Ala
        355                 360                 365             
Lys Asn Glu Met Lys Lys Leu Val Arg Ala Tyr Phe Lys Glu Thr Gln
    370                 375                 380                 
Trp Leu Asn Asp Cys Asp His Ile Pro Lys Tyr Glu Glu Gln Val Glu
385                 390                 395                 400 
Asn Ala Ile Val Ser Ala Gly Tyr Met Met Ile Ser Thr Thr Cys Leu
                405                 410                 415     
Val Gly Ile Glu Glu Phe Ile Ser His Glu Thr Phe Glu Trp Leu Met
            420                 425                 430         
Asn Glu Ser Val Ile Val Arg Ala Ser Ala Leu Ile Ala Arg Ala Met
        435                 440                 445             
Asn Asp Ile Val Gly His Glu Asp Glu Gln Glu Arg Gly His Val Ala
    450                 455                 460                 
Ser Leu Ile Glu Cys Tyr Met Lys Asp Tyr Gly Ala Ser Lys Gln Glu
465                 470                 475                 480 
Thr Tyr Ile Lys Phe Leu Lys Glu Val Thr Asn Ala Trp Lys Asp Ile
                485                 490                 495     
Asn Lys Gln Phe Phe Arg Pro Thr Glu Val Pro Met Phe Val Leu Glu
            500                 505                 510         
Arg Val Leu Asn Leu Thr Arg Val Ala Asp Thr Leu Tyr Lys Glu Lys
        515                 520                 525             
Asp Thr Tyr Thr Asn Ala Lys Gly Lys Leu Lys Asn Met Ile Asn Ser
    530                 535                 540                 
Ile Leu Ile Glu Ser Val Lys Ile
545                 550         


<210> 440
<211> 544
<212> PRT
<213> Lycopersicon hirsutum

<220> 
<223> germacrene B synthase Acc. No. AAG41891

<400> 440
Met Ala Ala Ser Ser Ala Asn Lys Ser Arg Pro Leu Ala Asn Phe His
 1               5                  10                  15      
Pro Thr Val Trp Gly Tyr His Phe Leu Ser Tyr Thr His Glu Ile Thr
            20                  25                  30          
Asn Gln Glu Lys Val Glu Val Asp Glu Tyr Lys Glu Thr Ile Arg Lys
        35                  40                  45              
Met Leu Val Glu Ala Pro Glu Gly Ser Glu Gln Lys Leu Val Leu Ile
    50                  55                  60                  
Asp Ala Met Gln Arg Leu Gly Val Ala Tyr His Phe His Asn Glu Ile
65                  70                  75                  80  
Glu Thr Ser Ile Gln Asn Ile Phe Asp Ala Pro Lys Gln Asn Asn Asn
                85                  90                  95      
Leu His Ile Val Ser Leu Arg Phe Arg Leu Val Arg Gln Gln Gly His
            100                 105                 110         
Tyr Met Ser Ser Asp Val Phe Lys Gln Phe Thr Asn Gln Asp Gly Lys
        115                 120                 125             
Phe Lys Glu Thr Leu Thr Asn Asp Val Gln Gly Leu Leu Ser Leu Tyr
    130                 135                 140                 
Glu Ala Ser Tyr Leu Arg Val Arg Asp Glu Glu Ile Leu Glu Glu Ala
145                 150                 155                 160 
Leu Ala Phe Thr Thr Thr His Leu Lys Ser Ile Val Ser Thr Met Ser
                165                 170                 175     
Asn Asn Asn Asn Ser Leu Lys Val Glu Val Ser Glu Ala Leu Thr Gln
            180                 185                 190         
Pro Ile Arg Met Thr Leu Pro Arg Met Glu Ala Arg Arg Tyr Ile Ser
        195                 200                 205             
Ile Tyr Glu Asn Asn Asp Ala His Asn His Leu Leu Leu Lys Phe Ala
    210                 215                 220                 
Lys Leu Asp Phe Asn Met Leu Gln Lys Leu His Gln Arg Glu Leu Ser
225                 230                 235                 240 
Asp Leu Thr Arg Trp Trp Lys Asp Leu Asp Phe Ala Asn Lys Tyr Pro
                245                 250                 255     
Tyr Ala Arg Asp Arg Leu Val Glu Cys Tyr Phe Trp Ile Leu Gly Val
            260                 265                 270         
Tyr Phe Glu Pro Lys Tyr Ser Arg Ala Arg Lys Met Met Thr Lys Val
        275                 280                 285             
Leu Lys Met Thr Ser Ile Ile Asp Asp Thr Phe Asp Ala Tyr Ala Thr
    290                 295                 300                 
Phe Asp Glu Leu Glu Pro Phe Asn Asp Ala Ile Gln Arg Trp Asp Ala
305                 310                 315                 320 
Asn Ala Ile Asp Ser Ile Pro Pro Tyr Met Arg Pro Ala Tyr Gln Ala
                325                 330                 335     
Phe Leu Asp Ile Tyr Ser Glu Met Glu Gln Val Leu Ser Lys Lys Gly
            340                 345                 350         
Lys Leu Asp Arg Val Tyr Tyr Ala Lys Asn Glu Met Lys Lys Leu Val
        355                 360                 365             
Arg Ala Tyr Phe Lys Glu Thr Gln Trp Leu Asn Asp Cys Asp His Ile
    370                 375                 380                 
Pro Lys Tyr Glu Glu His Met Glu Asn Ser Leu Val Ser Gly Gly Tyr
385                 390                 395                 400 
Met Met Ile Pro Thr Thr Cys Leu Val Gly Met Glu Glu Phe Ile Ser
                405                 410                 415     
Ile Glu Thr Phe Glu Trp Leu Met Asn Asp Pro Leu Ile Val Arg Ala
            420                 425                 430         
Ser Ser Leu Ile Ala Arg Ala Met Asn Asp Ile Val Gly His Glu Val
        435                 440                 445             
Glu Gln Glu Arg Gly His Val Ala Ser Leu Ile Glu Cys Tyr Met Lys
    450                 455                 460                 
Asp Tyr Gly Ala Ser Lys Gln Glu Ala Tyr Ala Lys Phe Lys Lys Asp
465                 470                 475                 480 
Val Thr Asn Ala Trp Lys Asp Ile Asn Lys Glu Phe Phe Arg Pro Thr
                485                 490                 495     
Glu Val Pro Met Phe Val Leu Glu Arg Val Leu Asn Leu Thr Arg Ala
            500                 505                 510         
Ala Glu Pro Leu Tyr Lys Glu Lys Asp Ala Tyr Thr Asn Ala Lys Gly
        515                 520                 525             
Lys Leu Lys Asn Met Ile Asn Ser Ile Leu Ile Glu Ser Val Lys Ile
    530                 535                 540                 


<210> 441
<211> 546
<212> PRT
<213> Lycopersicon hirsutum

<220> 
<223> germacrene D synthase Acc. No. AAG41892

<400> 441
Met Ala Ala Ser Phe Ala Asn Lys Cys Arg Pro Leu Ala Asn Phe His
 1               5                  10                  15      
Pro Thr Val Trp Gly Tyr His Phe Leu Tyr Tyr Asn Pro Glu Ile Thr
            20                  25                  30          
Asn Gln Glu Lys Ile Glu Val Asp Glu Tyr Lys Glu Thr Ile Arg Lys
        35                  40                  45              
Met Leu Val Glu Ala Pro Glu Gly Ser Glu Gln Lys Leu Val Leu Ile
    50                  55                  60                  
Asp Ala Met Gln Arg Leu Gly Val Ala Tyr His Phe His Asn Glu Ile
65                  70                  75                  80  
Glu Thr Ser Ile Gln Asn Ile Phe Asp Ala Pro Lys Gln Asn Asn Asp
                85                  90                  95      
Asp Asn Leu His Ile Val Ser Leu Arg Phe Arg Leu Val Arg Gln Gln
            100                 105                 110         
Gly His Tyr Met Ser Ser Asp Val Phe Lys Gln Phe Thr Asn Gln Asp
        115                 120                 125             
Gly Lys Phe Lys Glu Thr Leu Thr Asn Asp Val Gln Gly Leu Leu Ser
    130                 135                 140                 
Leu Tyr Glu Ala Ser His Leu Arg Val Arg Asn Glu Glu Ile Leu Glu
145                 150                 155                 160 
Glu Ala Leu Thr Phe Thr Thr Thr His Leu Glu Ser Ile Val Ser Asn
                165                 170                 175     
Leu Ser Asn Lys Asn Asn Ser Leu Lys Val Glu Val Ser Glu Ala Leu
            180                 185                 190         
Ser Gln Pro Ile Arg Met Thr Leu Pro Arg Ile Gly Ala Arg Lys Tyr
        195                 200                 205             
Ile Ser Ile Tyr Glu Asn Asn Asp Ala His Asn His Leu Leu Leu Lys
    210                 215                 220                 
Phe Ala Lys Leu Asp Phe Asn Met Leu Gln Lys Phe His Gln Arg Glu
225                 230                 235                 240 
Leu Ser Asp Leu Thr Arg Trp Trp Lys Asp Leu Asp Phe Ala Asn Lys
                245                 250                 255     
Ile Pro Tyr Ala Arg Asp Arg Leu Val Glu Cys Tyr Phe Trp Ile Leu
            260                 265                 270         
Gly Val Tyr Phe Glu Pro Lys Tyr Ser Arg Ala Arg Lys Met Met Thr
        275                 280                 285             
Lys Val Leu Lys Met Thr Ser Ile Ile Asp Asp Thr Phe Asp Ala Tyr
    290                 295                 300                 
Ala Asn Phe Asp Glu Leu Val Pro Phe Asn Asp Ala Ile Gln Arg Trp
305                 310                 315                 320 
Asp Ala Asn Ala Ile Asp Ser Ile Pro Pro Tyr Met Arg Pro Ile Tyr
                325                 330                 335     
Gln Ala Leu Leu Asp Ile Tyr Gly Glu Met Asp Gln Val Leu Ser Lys
            340                 345                 350         
Glu Gly Lys Leu Asp Arg Val Tyr Tyr Ala Lys Tyr Glu Met Lys Lys
        355                 360                 365             
Leu Val Arg Ala Tyr Phe Lys Glu Ser Gln Trp Leu Asn Asp Asp Asn
    370                 375                 380                 
His Ile Pro Lys Tyr Glu Glu His Met Glu Asn Ala Ile Val Thr Val
385                 390                 395                 400 
Gly Tyr Met Met Gly Ala Thr Asn Cys Leu Val Gly Met Glu Glu Phe
                405                 410                 415     
Ile Ser Lys Glu Thr Phe Glu Trp Leu Met Ser Glu Pro Val Ile Val
            420                 425                 430         
Arg Ala Ser Ser Leu Ile Gly Arg Ala Met Asp Asp Ile Val Gly His
        435                 440                 445             
Glu Val Glu Gln Glu Arg Gly His Val Ala Ser Ile Ile Glu Cys Tyr
    450                 455                 460                 
Met Lys Asp Tyr Gly Ala Ser Lys Gln Glu Ala Tyr Ala Lys Phe Lys
465                 470                 475                 480 
Lys Asp Val Thr Asn Ala Trp Lys Asp Ile Asn Lys Glu Phe Phe Arg
                485                 490                 495     
Pro Thr Glu Val Pro Met Phe Val Leu Glu Arg Ala Leu Asn Phe Thr
            500                 505                 510         
Arg Val Ile Asp Thr Leu Tyr Gln Glu Glu Asp Glu Tyr Thr Asn Ala
        515                 520                 525             
Lys Gly Lys Leu Lys Asn Met Ile His Ser Ile Leu Ile Glu Ser Val
    530                 535                 540                 
Lys Ile
545     


<210> 442
<211> 550
<212> PRT
<213> Magnolia grandiflora

<220> 
<223> beta-cubebene synthase Acc. No. ACC66281

<400> 442
Met Asp Ser Pro Thr Thr Gln Arg Pro Asn Met Glu Ile Gly Arg Ala
 1               5                  10                  15      
Phe Val Asn Tyr His Pro Ser Ile Trp Gly Glu His Phe Ile Ala Ala
            20                  25                  30          
Ser Pro Asp Val Met Arg Leu Asp Ala His Lys Gly Arg Gly Glu Glu
        35                  40                  45              
Leu Lys Glu Val Val Arg Asn Met Phe Ser Thr Val Asn Asp Pro Leu
    50                  55                  60                  
Leu Lys Met Asn Leu Ile Asp Ala Ile Gln Arg Leu Gly Val Ala Tyr
65                  70                  75                  80  
His Phe Glu Met Glu Ile Asp Lys Ala Leu Gly Gln Met Tyr Asp Asp
                85                  90                  95      
His Ile Asn Gly Lys Asp Asp Gly Phe Asp Leu Gln Thr Leu Ala Leu
            100                 105                 110         
Gln Phe Arg Leu Leu Arg Gln Gln Gly Tyr Asn Val Ser Ser Gly Val
        115                 120                 125             
Phe Ala Lys Phe Lys Asp Asp Glu Gly Asn Phe Ser Ser Ile Leu Ser
    130                 135                 140                 
Lys Asp Thr His Gly Leu Leu Ser Leu Tyr Glu Ala Ala Phe Leu Gly
145                 150                 155                 160 
Thr His Gly Asp Asp Ile Leu Asp Glu Ala Ile Thr Phe Thr Thr Val
                165                 170                 175     
His Leu Lys Ser Thr Leu Pro His Val Ser Ala Pro Leu Thr Lys Leu
            180                 185                 190         
Val Glu Leu Ala Leu Glu Ile Pro Leu His Arg Arg Met Glu Arg Leu
        195                 200                 205             
Gln Thr Arg Phe Tyr Ile Ser Ile Tyr Glu Glu Asp Arg Glu Arg Asn
    210                 215                 220                 
Asp Val Leu Leu Glu Phe Ser Lys Leu Glu Phe Leu Arg Leu Gln Ser
225                 230                 235                 240 
Leu His Gln Arg Glu Leu Arg Asp Ile Ser Leu Trp Trp Lys Glu Met
                245                 250                 255     
Asp Leu Leu Ala Lys Leu Pro Phe Thr Arg Asp Arg Val Leu Glu Gly
            260                 265                 270         
Tyr Phe Trp Thr Val Gly Val Tyr Phe Glu Pro His Tyr Ser Arg Ala
        275                 280                 285             
Arg Met Ile Met Thr Lys Met Ile Ala Phe Ala Thr Val Met Asp Asp
    290                 295                 300                 
Thr Tyr Asp Val Tyr Gly Thr Leu Glu Glu Leu Glu Leu Leu Thr Ala
305                 310                 315                 320 
Thr Ile Glu Arg Trp Asn Arg Gly Asp Met Asp Gln Leu Pro Asp Tyr
                325                 330                 335     
Met Lys Val Ile Phe Ile Ala Leu Leu Asp Gly Val Asp Ala Thr Glu
            340                 345                 350         
Asp Asp Leu Thr Gly Glu Gly Lys Ser Tyr Arg Ile Tyr Tyr Leu Lys
        355                 360                 365             
Glu Ala Val Lys Asp Leu Ala Lys Ala Tyr Leu Ala Glu Ala Arg Trp
    370                 375                 380                 
Val Ser Ser Gly Tyr Val Pro Thr Ser Glu Glu Tyr Met Lys Val Ala
385                 390                 395                 400 
Leu Ile Ser Ala Val Tyr Pro Met Leu Phe Val Ala Phe Leu Ile Gly
                405                 410                 415     
Met Asp Glu Val Val Thr Lys Glu Val Leu Glu Trp Ala Ile His Met
            420                 425                 430         
Pro Thr Met Leu Arg Thr Cys Ser Ile Val Ala Arg Leu Met Asp Asp
        435                 440                 445             
Ile Pro Ser Asn Lys Leu Glu Gln Glu Arg Lys His Val Ser Ser Ser
    450                 455                 460                 
Val Glu Cys Tyr Met Lys Glu His Gly Thr Ser Tyr His Glu Ser Ile
465                 470                 475                 480 
Gln Lys Leu Arg Glu Met Val Ala Ser Gly Trp Lys Asp Ile Asn Lys
                485                 490                 495     
Glu Cys Leu Lys Pro Thr Pro Val Pro Thr Ala Val Ile Asn Val Ile
            500                 505                 510         
Leu Asn Phe Thr Arg Val Leu Glu Ile Ile Tyr Gln His Arg Asp Gly
        515                 520                 525             
Tyr Thr Asp Ala Ser Val Glu Thr Lys Glu His Ile Ala Ser Leu Phe
    530                 535                 540                 
Val Asp Pro Ile Pro Leu
545                 550 


<210> 443
<211> 576
<212> PRT
<213> Malus x domestica (

<220> 
<223> (E,E)-alpha-farnesene synthase Acc. No. AAO22848

<400> 443
Met Glu Phe Arg Val His Leu Gln Ala Asp Asn Glu Gln Lys Ile Phe
 1               5                  10                  15      
Gln Asn Gln Met Lys Pro Glu Pro Glu Ala Ser Tyr Leu Ile Asn Gln
            20                  25                  30          
Arg Arg Ser Ala Asn Tyr Lys Pro Asn Ile Trp Lys Asn Asp Phe Leu
        35                  40                  45              
Asp Gln Ser Leu Ile Ser Lys Tyr Asp Gly Asp Glu Tyr Arg Lys Leu
    50                  55                  60                  
Ser Glu Lys Leu Ile Glu Glu Val Lys Ile Tyr Ile Ser Ala Glu Thr
65                  70                  75                  80  
Met Asp Leu Val Ala Lys Leu Glu Leu Ile Asp Ser Val Arg Lys Leu
                85                  90                  95      
Gly Leu Ala Asn Leu Phe Glu Lys Glu Ile Lys Glu Ala Leu Asp Ser
            100                 105                 110         
Ile Ala Ala Ile Glu Ser Asp Asn Leu Gly Thr Arg Asp Asp Leu Tyr
        115                 120                 125             
Gly Thr Ala Leu His Phe Lys Ile Leu Arg Gln His Gly Tyr Lys Val
    130                 135                 140                 
Ser Gln Asp Ile Phe Gly Arg Phe Met Asp Glu Lys Gly Thr Leu Glu
145                 150                 155                 160 
Asn His His Phe Ala His Leu Lys Gly Met Leu Glu Leu Phe Glu Ala
                165                 170                 175     
Ser Asn Leu Gly Phe Glu Gly Glu Asp Ile Leu Asp Glu Ala Lys Ala
            180                 185                 190         
Ser Leu Thr Leu Ala Leu Arg Asp Ser Gly His Ile Cys Tyr Pro Asp
        195                 200                 205             
Ser Asn Leu Ser Arg Asp Val Val His Ser Leu Glu Leu Pro Ser His
    210                 215                 220                 
Arg Arg Val Gln Trp Phe Asp Val Lys Trp Gln Ile Asn Ala Tyr Glu
225                 230                 235                 240 
Lys Asp Ile Cys Arg Val Asn Ala Thr Leu Leu Glu Leu Ala Lys Leu
                245                 250                 255     
Asn Phe Asn Val Val Gln Ala Gln Leu Gln Lys Asn Leu Arg Glu Ala
            260                 265                 270         
Ser Arg Trp Trp Ala Asn Leu Gly Ile Ala Asp Asn Leu Lys Phe Ala
        275                 280                 285             
Arg Asp Arg Leu Val Glu Cys Phe Ala Cys Ala Val Gly Val Ala Phe
    290                 295                 300                 
Glu Pro Glu His Ser Ser Phe Arg Ile Cys Leu Thr Lys Val Ile Asn
305                 310                 315                 320 
Leu Val Leu Ile Ile Asp Asp Val Tyr Asp Ile Tyr Gly Ser Glu Glu
                325                 330                 335     
Glu Leu Lys His Phe Thr Asn Ala Val Asp Arg Trp Asp Ser Arg Glu
            340                 345                 350         
Thr Glu Gln Leu Pro Glu Cys Met Lys Met Cys Phe Gln Val Leu Tyr
        355                 360                 365             
Asn Thr Thr Cys Glu Ile Ala Arg Glu Ile Glu Glu Glu Asn Gly Trp
    370                 375                 380                 
Asn Gln Val Leu Pro Gln Leu Thr Lys Val Trp Ala Asp Phe Cys Lys
385                 390                 395                 400 
Ala Leu Leu Val Glu Ala Glu Trp Tyr Asn Lys Ser His Ile Pro Thr
                405                 410                 415     
Leu Glu Glu Tyr Leu Arg Asn Gly Cys Ile Ser Ser Ser Val Ser Val
            420                 425                 430         
Leu Leu Val His Ser Phe Phe Ser Ile Thr His Glu Gly Thr Lys Glu
        435                 440                 445             
Met Ala Asp Phe Leu His Lys Asn Glu Asp Leu Leu Tyr Asn Ile Ser
    450                 455                 460                 
Leu Ile Val Arg Leu Asn Asn Asp Leu Gly Thr Ser Ala Ala Glu Gln
465                 470                 475                 480 
Glu Arg Gly Asp Ser Pro Ser Ser Ile Val Cys Tyr Met Arg Glu Val
                485                 490                 495     
Asn Ala Ser Glu Glu Thr Ala Arg Lys Asn Ile Lys Gly Met Ile Asp
            500                 505                 510         
Asn Ala Trp Lys Lys Val Asn Gly Lys Cys Phe Thr Thr Asn Gln Val
        515                 520                 525             
Pro Phe Leu Ser Ser Phe Met Asn Asn Ala Thr Asn Met Ala Arg Val
    530                 535                 540                 
Ala His Ser Leu Tyr Lys Asp Gly Asp Gly Phe Gly Asp Gln Glu Lys
545                 550                 555                 560 
Gly Pro Arg Thr His Ile Leu Ser Leu Leu Phe Gln Pro Leu Val Asn
                565                 570                 575     


<210> 444
<211> 553
<212> PRT
<213> Medicago truncatula

<220> 
<223> (-)-cubebol synthase Acc. No. ABB01625

<400> 444
Met Ser Thr Val Ala Tyr Ser Asp His Asp Ala Lys Gln Arg Asn Leu
 1               5                  10                  15      
Ala Asp Tyr His Pro Ser Val Trp Gly Gly Phe Phe Leu Gln Tyr Ala
            20                  25                  30          
Ser Glu Thr Met Glu Leu Asp Gln Asn Leu Ala Ser Gln Ile Asp Thr
        35                  40                  45              
Leu Lys Asp Glu Val Arg Asn Met Leu Val Ser Lys Thr Glu Met Pro
    50                  55                  60                  
Leu Thr Lys Val Lys Leu Ile Asp Ser Ile Cys Arg Leu Gly Val Gly
65                  70                  75                  80  
Tyr His Phe Glu Lys Glu Ile Asp Glu Val Leu Gln His Ile His Lys
                85                  90                  95      
Ser Tyr Val Glu Asn Gly Glu Ile Thr Leu Glu Asp Ser Leu Cys Ser
            100                 105                 110         
Leu Ala Met Leu Phe Arg Val Phe Arg Gln Gln Gly Leu His Val Ser
        115                 120                 125             
Pro Asn Val Phe Asn Lys Phe Lys Asp Lys Gln Gly Asn Phe Asn Glu
    130                 135                 140                 
Asn Leu Ser Thr Asp Val Glu Gly Met Leu Ser Leu Tyr Glu Ala Ser
145                 150                 155                 160 
His Met Met Val His Glu Asp Asp Ile Leu Glu Glu Ala Leu Asn Phe
                165                 170                 175     
Thr Ser Thr His Leu Glu Ser Ile Ala Ser Gln Ser Ser Pro Ser Leu
            180                 185                 190         
Ala Ala Gln Ile Glu Tyr Thr Leu Lys Gln Ala Leu His Lys Asn Ile
        195                 200                 205             
Pro Arg Leu Glu Ala Arg His Tyr Ile Ser Ile Tyr Glu Lys Asp Pro
    210                 215                 220                 
Thr Cys Asp Glu Val Leu Leu Thr Phe Ala Lys Leu Asp Phe Asn Leu
225                 230                 235                 240 
Leu Gln Ser Leu His Gln Lys Glu Phe Gly Asn Ile Ser Lys Trp Trp
                245                 250                 255     
Lys Glu Leu Asp Phe Ser Thr Lys Leu Pro Tyr Ala Arg Asp Arg Ile
            260                 265                 270         
Ala Glu Cys Ser Phe Trp Val Leu Thr Ala Phe Phe Glu Pro Gln Tyr
        275                 280                 285             
Ser Gln Ala Arg Lys Met Met Ile Lys Val Ile Thr Leu Leu Ser Ile
    290                 295                 300                 
Ile Asp Asp Thr Tyr Asp Ala Tyr Gly Thr Ile Asp Glu Leu Glu Leu
305                 310                 315                 320 
Phe Thr Lys Ala Val Glu Arg Trp Asp Ile Ser Ser Leu Asp Glu Leu
                325                 330                 335     
Pro Asp Tyr Met Lys Pro Ile Tyr Arg Ser Phe Leu Thr Ile Tyr Glu
            340                 345                 350         
Glu Ile Glu Lys Glu Met Arg Lys Glu Gly Arg Ile Tyr Thr Leu Asp
        355                 360                 365             
Tyr Tyr Lys Ile Glu Phe Lys Lys Ser Val Gln Ala Phe Met Thr Glu
    370                 375                 380                 
Ala Arg Trp Leu Asn Glu Asn His Ile Pro Thr Thr Glu Glu Tyr Met
385                 390                 395                 400 
Arg Ile Ser Lys Lys Ser Gly Ala Tyr Pro Leu Leu Ile Leu Thr Ser
                405                 410                 415     
Tyr Ile Gly Met Gly Asp Ile Ala Thr Lys Glu Ile Phe Asn Trp Val
            420                 425                 430         
Ser Asn Glu Pro Arg Ile Val Asn Ala Ala Ala Thr Leu Cys Arg Leu
        435                 440                 445             
Met Asp Glu Ile Val Ser Ser Glu Phe Glu Gln Lys Arg Gly His Val
    450                 455                 460                 
Cys Ser Leu Leu Asp Cys Tyr Met Lys Gln Phe Asp Met Ser Arg Glu
465                 470                 475                 480 
Ala Ala Ile Gln Glu Cys Lys Asn Arg Met Thr Ile Val Trp Lys Asp
                485                 490                 495     
Ile Asn Glu Glu Cys Leu Arg Pro Thr Glu Val Pro Met Pro Phe Met
            500                 505                 510         
Thr Arg Val Leu Asn Leu Ser Arg Phe Met Asp Val Ile Tyr Lys Asn
        515                 520                 525             
Lys Asp Asn Tyr Thr Asp Ser Asp Gly Leu Met Lys Thr Cys Ile Lys
    530                 535                 540                 
Glu Val Leu Val Asp Pro Val Pro Ile
545                 550             


<210> 445
<211> 562
<212> PRT
<213> Medicago truncatula

<220> 
<223> (E)-beta-caryophyllene synthase Acc. No. AAV36464

<400> 445
Met Ser Val Ser Val Thr Ser Ser Leu Val Ala Pro Thr Pro Asn Ala
 1               5                  10                  15      
Asn Ser Asp Phe Ser Arg Arg Ser Ala Asn Tyr His Pro Asn Ile Trp
            20                  25                  30          
Gly Asp Leu Phe Ile Gln Tyr Val Leu Glu Pro Met Glu Phe Asp Glu
        35                  40                  45              
Ile Met Lys Gln Ile Ile Met Leu Lys Glu Lys Val Arg Gln Met Leu
    50                  55                  60                  
Val Pro Asn Val Asn Val Thr Asn Pro Ser Arg Glu Ala Asn Leu Ile
65                  70                  75                  80  
Asp Ser Ile Gln Arg Leu Gly Leu Tyr His His Phe Glu Gln Glu Ile
                85                  90                  95      
Gly Glu Leu Leu Arg His Ile Asp Asn Asn His Val Glu Asn Gly Thr
            100                 105                 110         
Ile Thr Leu Asn Glu Asp Leu His Ser Ile Ala Leu Val Phe Arg Leu
        115                 120                 125             
Leu Arg Gln Gln Gly Tyr His Ile Leu Pro Asp Val Phe Lys Lys Phe
    130                 135                 140                 
Lys Asn Glu Gln Gly Asn Phe Lys Glu Thr Leu Val Gly Asp Val Glu
145                 150                 155                 160 
Gly Met Leu Ser Leu Tyr Glu Ala Thr His Met Arg Ile His Gly Glu
                165                 170                 175     
Glu Ile Leu Asp Asp Ala Leu Ser Phe Thr Ser Leu His Leu Glu Met
            180                 185                 190         
Met Thr Thr Gln Leu Ser Pro Ser Val Ala Thr Lys Ile Asn His Ser
        195                 200                 205             
Leu Lys Arg Pro Leu Phe Lys Asn Leu Pro Arg Leu Val Ala Arg His
    210                 215                 220                 
Tyr Ile Ser Thr Tyr Glu Glu Asp Pro Ser His Asp Ala Thr Leu Leu
225                 230                 235                 240 
Leu Leu Ala Lys Leu Asp Phe Asn Leu Leu Gln Lys Gln His Gln Lys
                245                 250                 255     
Glu Val Gly Asp Ile Ser Lys Trp Trp Lys Asp Leu Asp Phe Ala Thr
            260                 265                 270         
Lys Leu Pro Phe Ala Arg Asn Arg Ile Val Glu Ala Tyr Phe Trp Ile
        275                 280                 285             
Leu Gly Val Tyr Phe Glu Pro Gln Tyr Ser Phe Gly Arg Arg Ile Met
    290                 295                 300                 
Thr Lys Val Ile Ser Leu Ala Ser Val Ile Asp Asp Ile Tyr Asp Val
305                 310                 315                 320 
Tyr Gly Thr Ile Glu Glu Leu Gln Leu Phe Thr Gln Ala Ile Glu Arg
                325                 330                 335     
Trp Asp Ile Ser Cys Met Asp Phe Leu Pro Gln Tyr Met Lys Phe Cys
            340                 345                 350         
Tyr Lys Ala Val Leu Asp Val Tyr Glu Glu Met Glu Gln Glu Met Val
        355                 360                 365             
Lys Glu Gly Arg Ala Phe Cys Val Phe Tyr Ala Lys Asn Glu Met Lys
    370                 375                 380                 
Arg Leu Val Gln Ala Tyr Phe Thr Glu Ala Lys Trp Phe Ser Arg Asn
385                 390                 395                 400 
Tyr Ile Pro Thr Val Asp Glu Tyr Met Ala Leu Gly Ile Val Asn Ser
                405                 410                 415     
Gly Tyr Tyr Leu Ile Thr Ala Thr Ser Phe Ile Gly Met Gly Cys Ile
            420                 425                 430         
Ala Thr Glu Asp Val Phe Gln Trp Leu Thr Asn Asn Pro Lys Ile Val
        435                 440                 445             
Asn Ala Ser Ser Lys Ile Ala Arg Leu Met Asp Asp Ile Val Ser Asn
    450                 455                 460                 
Glu Phe Glu Gln Glu Arg Gly His Gly Ala Ser Ala Ile Glu Cys Tyr
465                 470                 475                 480 
Met Asn Glu His Gly Val Ser Arg Glu Asp Ala Val Asn Glu Leu Ser
                485                 490                 495     
Arg Gln Val Thr Asn Ala Trp Lys Asp Thr Asn Glu Glu Leu Leu Asp
            500                 505                 510         
Pro Thr Glu Val Pro Lys Pro Leu Leu Ile Arg Val Leu Asn Leu Ser
        515                 520                 525             
Arg Val Ile Asp Val Leu Tyr Lys Asp Gly Asp Cys Tyr Thr Asn Ser
    530                 535                 540                 
Gln Gly Ser Thr Lys Asn Asp Ile Ile Ser Ile Leu Leu Asn Pro Cys
545                 550                 555                 560 
Pro Val
        


<210> 446
<211> 573
<212> PRT
<213> Medicago truncatula

<220> 
<223> 3S-(E)-nerolidol synthase Acc. No. AAV36466

<400> 446
Met Ala Phe Ser Leu Ser Phe Ala Thr Ser Thr Lys His Ser Thr Phe
 1               5                  10                  15      
Ser Ser Asn Lys Thr Ser Asn Ile Leu Glu Tyr Asn Lys Thr Asn Leu
            20                  25                  30          
Thr Ser Val Phe Asn Gln Ile His Ile Pro Lys Ser Gly Lys Cys Lys
        35                  40                  45              
Asp Asp Leu His Ile Arg His Ala Lys Ala Leu Asp Glu Val Lys Gln
    50                  55                  60                  
Val Phe Val Arg Asn Ile Arg Lys Asn Thr Asp Glu Cys Leu Ser Met
65                  70                  75                  80  
Val Asp Ser Ile Gln Arg Leu Gly Met Glu Tyr Asn Phe Glu Glu Glu
                85                  90                  95      
Ile Glu Ala Thr Leu Glu Arg Lys His Thr Met Leu Arg Phe Gln Asn
            100                 105                 110         
Phe Gln Arg Asn Glu Tyr Gln Gly Leu Ser Gln Ala Ala Phe Gln Phe
        115                 120                 125             
Arg Met Leu Arg Gln Glu Gly Tyr Tyr Ile Ser Pro Asp Ile Phe Asp
    130                 135                 140                 
Lys Phe Cys Asp Asn Lys Gly Lys Leu Lys Tyr Thr Phe Ser Glu Asp
145                 150                 155                 160 
Ile Asn Gly Met Ile Ala Leu Phe Glu Ala Ser Gln Leu Ser Ile Glu
                165                 170                 175     
Gly Glu Asp Cys Leu Asp Asn Val Gly Gln Phe Cys Gly Gln Tyr Leu
            180                 185                 190         
Asn Asp Trp Ser Ser Thr Phe His Gly His Pro Gln Ala Lys Phe Val
        195                 200                 205             
Ala His Thr Leu Met Tyr Pro Thr His Lys Thr Leu Ser Arg Phe Thr
    210                 215                 220                 
Pro Thr Ile Met Gln Ser Gln Asn Ala Thr Trp Thr Asn Ser Ile Gln
225                 230                 235                 240 
Gln Phe Ser Lys Ile Asp Thr Gln Met Val Ser Ser Ser His Leu Lys
                245                 250                 255     
Glu Ile Phe Ala Val Ser Lys Trp Trp Lys Asp Leu Gly Leu Pro Lys
            260                 265                 270         
Asp Leu Glu Phe Ala Arg Asp Glu Pro Ile Lys Trp Tyr Ser Trp Ser
        275                 280                 285             
Met Ala Cys Leu Pro Asp Pro Gln Phe Ser Glu Glu Arg Ile Glu Leu
    290                 295                 300                 
Thr Lys Pro Leu Ser Leu Ile Tyr Ile Ile Asp Asp Ile Phe Asp Phe
305                 310                 315                 320 
Tyr Gly Asn Ile Asp Glu Leu Thr Leu Phe Thr Asp Ala Val Lys Arg
                325                 330                 335     
Trp Asp Leu Ser Ala Ile Glu Gln Leu Pro Asp Cys Met Lys Val Cys
            340                 345                 350         
Phe Lys Ala Leu Tyr Asp Ile Thr Asn Glu Phe Ala Leu Arg Thr Tyr
        355                 360                 365             
Ile Lys His Gly Trp Asn Pro Leu Thr Ser Leu Ile Lys Ser Trp Val
    370                 375                 380                 
Arg Leu Leu Asn Ala Phe Leu Gln Glu Ala Lys Trp Phe Ala Ser Gly
385                 390                 395                 400 
Asn Val Pro Lys Ser Glu Glu Tyr Leu Lys Asn Ala Ile Val Ser Thr
                405                 410                 415     
Gly Val His Val Ile Leu Val His Ala Phe Phe Cys Met Gly Gln Gly
            420                 425                 430         
Ile Thr Glu Lys Thr Val Ser Leu Met Asp Asp Phe Pro Thr Ile Ile
        435                 440                 445             
Ser Thr Thr Ala Lys Ile Leu Arg Leu Cys Asp Asp Leu Glu Gly Asp
    450                 455                 460                 
Lys Asp Val Asn Cys Glu Gly Asn Asp Gly Ser Tyr Ser Lys Cys Tyr
465                 470                 475                 480 
Met Lys Asp Asn Pro Gly Val Ser Ile Gly Leu Thr Lys Glu His Met
                485                 490                 495     
Ser Glu Gln Ile Ser Asp Ala Trp Lys Gln Leu Asn Lys Glu Cys Leu
            500                 505                 510         
Asn Thr Asn Pro Leu Pro Ser Ser Phe Thr Lys Leu Cys Leu Asn Ala
        515                 520                 525             
Ala Arg Met Val Pro Ile Met Tyr Asn Tyr Asp Gly Asn Thr Pro Ser
    530                 535                 540                 
Lys Leu Glu Glu Tyr Val Lys Ser Leu Leu Asn Asp Gly Gly Tyr Leu
545                 550                 555                 560 
Gln Ser Ile His Ser Pro Thr Ser Glu His Ser Thr Val
                565                 570             


<210> 447
<211> 551
<212> PRT
<213> Mentha x pipereta

<220> 
<223> (Z)-muurola-3,5-diene synthase Acc. No. CAH10288

<400> 447
Met Ala Thr Asn Gly Val Val Ile Ser Cys Leu Arg Glu Val Arg Pro
 1               5                  10                  15      
Pro Met Thr Lys His Ala Pro Ser Met Trp Thr Asp Thr Phe Ser Asn
            20                  25                  30          
Phe Ser Leu Asp Asp Lys Glu Gln Gln Lys Arg Ser Glu Thr Ile Glu
        35                  40                  45              
Ala Leu Lys Gln Glu Ala Arg Gly Met Leu Met Ala Ala Thr Thr Pro
    50                  55                  60                  
Leu Gln Gln Met Thr Leu Ile Asp Thr Leu Glu Arg Leu Gly Leu Ala
65                  70                  75                  80  
Phe His Phe Glu Thr Glu Val Glu Tyr Lys Ile Glu Gln Ile Asn Ala
                85                  90                  95      
Ala Ala Glu Asp Asp Gly Phe Asp Leu Phe Ala Thr Ala Leu Arg Phe
            100                 105                 110         
Arg Leu Leu Arg Gln His Gln Arg His Val Ser Cys Asp Val Phe Asp
        115                 120                 125             
Lys Phe Val Asp Lys Asp Gly Lys Phe Glu Glu Ser Leu Ser Asn Asn
    130                 135                 140                 
Val Glu Gly Leu Leu Ser Leu Tyr Glu Ala Ala His Val Gly Phe Arg
145                 150                 155                 160 
Glu Glu Arg Ile Leu Gln Glu Ala Val Asn Phe Thr Arg His His Leu
                165                 170                 175     
Glu Gly Ala Glu Leu Asp Gln Ser Pro Leu Leu Ile Arg Glu Lys Val
            180                 185                 190         
Lys Arg Ala Leu Glu His Pro Leu His Arg Asp Phe Pro Ile Val Tyr
        195                 200                 205             
Ala Arg Leu Phe Ile Ser Ile Tyr Glu Lys Asp Asp Ser Arg Asp Glu
    210                 215                 220                 
Leu Leu Leu Lys Leu Ser Lys Val Asn Phe Lys Phe Met Gln Asn Leu
225                 230                 235                 240 
Tyr Lys Lys Glu Leu Ser Gln Leu Ser Arg Trp Trp Asn Thr Trp Asp
                245                 250                 255     
Leu Lys Ser Lys Leu Pro Tyr Ala Arg Asp Arg Val Val Glu Ala Tyr
            260                 265                 270         
Val Trp Gly Val Gly Tyr His Tyr Glu Pro Gln Tyr Ser Tyr Val Arg
        275                 280                 285             
Met Gly Leu Ala Lys Gly Ile Leu Ile Ile Gly Ile Met Asp Asp Thr
    290                 295                 300                 
Tyr Asp Asn Tyr Ala Thr Leu Asn Glu Ala Gln Leu Phe Thr Gln Val
305                 310                 315                 320 
Leu Asp Lys Trp Asp Arg Asp Glu Ala Asp Arg Leu Pro Glu Tyr Met
                325                 330                 335     
Lys Ile Val Tyr Glu Phe Ile Leu Ser Thr Cys Glu Asn Tyr Glu Arg
            340                 345                 350         
Asp Ala Ala Lys Leu Gly Lys Ser Phe Ala Ala Pro Tyr Phe Lys Glu
        355                 360                 365             
Thr Val Lys Gln Leu Ala Arg Ala Phe Asn Gln Glu Gln Lys Trp Val
    370                 375                 380                 
Met Glu Arg Gln Leu Pro Ser Phe Gln Asp Tyr Val Lys Asn Ser Glu
385                 390                 395                 400 
Lys Thr Ser Cys Ile Tyr Thr Met Phe Ala Ser Ile Ile Pro Gly Leu
                405                 410                 415     
Lys Ser Val Thr Gln Glu Thr Ile Asp Trp Ile Lys Ser Glu Pro Thr
            420                 425                 430         
Leu Ala Thr Ser Thr Gly Met Ile Gly Arg Tyr Trp Asp Asp Ile Gly
        435                 440                 445             
Ser His Leu Arg Glu Ser Lys Gly Gly Glu Met Leu Thr Ala Leu Asp
    450                 455                 460                 
Phe His Met Lys Glu Tyr Gly Leu Thr Lys Glu Glu Ala Ala Ser Lys
465                 470                 475                 480 
Phe Glu Gly Leu Val Glu Glu Thr Trp Lys Asp Ile Asn Lys Glu Phe
                485                 490                 495     
Ile Ala Thr Thr Asn Tyr Asn Val Gly Arg Glu Ile Ala Ile Thr Phe
            500                 505                 510         
Leu Asn Tyr Ala Arg Ile Cys Glu Ala Ser Tyr Ser Lys Thr Asp Gly
        515                 520                 525             
Asp Ala Tyr Leu Asp Pro Asn Val Ala Lys Ala Asn Val Val Ala Leu
    530                 535                 540                 
Phe Val Asp Ala Ile Val Phe
545                 550     


<210> 448
<211> 550
<212> PRT
<213> Mentha x pipereta

<220> 
<223> (E)-beta-farnesene synthase Acc. No. AAB95209

<400> 448
Met Ala Thr Asn Gly Val Val Ile Ser Cys Leu Arg Glu Val Arg Pro
 1               5                  10                  15      
Pro Met Thr Lys His Ala Pro Ser Met Trp Thr Asp Thr Phe Ser Asn
            20                  25                  30          
Phe Ser Leu Asp Asp Lys Glu Gln Gln Lys Cys Ser Glu Thr Ile Glu
        35                  40                  45              
Ala Leu Lys Gln Glu Ala Arg Gly Met Leu Met Ala Ala Thr Thr Pro
    50                  55                  60                  
Leu Gln Gln Met Thr Leu Ile Asp Thr Leu Glu Arg Leu Gly Leu Ser
65                  70                  75                  80  
Phe His Phe Glu Thr Glu Ile Glu Tyr Lys Ile Glu Leu Ile Asn Ala
                85                  90                  95      
Ala Glu Asp Asp Gly Phe Asp Leu Phe Ala Thr Ala Leu Arg Phe Arg
            100                 105                 110         
Leu Leu Arg Gln His Gln Arg His Val Ser Cys Asp Val Phe Asp Lys
        115                 120                 125             
Phe Ile Asp Lys Asp Gly Lys Phe Glu Glu Ser Leu Ser Asn Asn Val
    130                 135                 140                 
Glu Gly Leu Leu Ser Leu Tyr Glu Ala Ala His Val Gly Phe Arg Glu
145                 150                 155                 160 
Glu Arg Ile Leu Gln Glu Ala Val Asn Phe Thr Arg His His Leu Glu
                165                 170                 175     
Gly Ala Glu Leu Asp Gln Ser Pro Leu Leu Ile Arg Glu Lys Val Lys
            180                 185                 190         
Arg Ala Leu Glu His Pro Leu His Arg Asp Phe Pro Ile Val Tyr Ala
        195                 200                 205             
Arg Leu Phe Ile Ser Ile Tyr Glu Lys Asp Asp Ser Arg Asp Glu Leu
    210                 215                 220                 
Leu Leu Lys Leu Ser Lys Val Asn Phe Lys Phe Met Gln Asn Leu Tyr
225                 230                 235                 240 
Lys Glu Glu Leu Ser Gln Leu Ser Arg Trp Trp Asn Thr Trp Asn Leu
                245                 250                 255     
Lys Ser Lys Leu Pro Tyr Ala Arg Asp Arg Val Val Glu Ala Tyr Val
            260                 265                 270         
Trp Gly Val Gly Tyr His Tyr Glu Pro Gln Tyr Ser Tyr Val Arg Met
        275                 280                 285             
Gly Leu Ala Lys Gly Val Leu Ile Cys Gly Ile Met Asp Asp Thr Tyr
    290                 295                 300                 
Asp Asn Tyr Ala Thr Leu Asn Glu Ala Gln Leu Phe Thr Gln Val Leu
305                 310                 315                 320 
Asp Lys Trp Asp Arg Asp Glu Ala Glu Arg Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Ile Val Tyr Arg Phe Ile Leu Ser Ile Tyr Glu Asn Tyr Glu Arg Asp
            340                 345                 350         
Ala Ala Lys Leu Gly Lys Ser Phe Ala Ala Pro Tyr Phe Lys Glu Thr
        355                 360                 365             
Val Lys Gln Leu Ala Arg Ala Phe Asn Glu Glu Gln Lys Trp Val Met
    370                 375                 380                 
Glu Arg Gln Leu Pro Ser Phe Gln Asp Tyr Val Lys Asn Ser Glu Lys
385                 390                 395                 400 
Thr Ser Cys Ile Tyr Thr Met Phe Ala Ser Ile Ile Pro Gly Leu Lys
                405                 410                 415     
Ser Val Thr Gln Glu Thr Ile Asp Trp Ile Lys Ser Glu Pro Thr Leu
            420                 425                 430         
Ala Thr Ser Thr Ala Met Ile Gly Arg Tyr Trp Asn Asp Thr Ser Ser
        435                 440                 445             
Gln Leu Arg Glu Ser Lys Gly Gly Glu Met Leu Thr Ala Leu Asp Phe
    450                 455                 460                 
His Met Lys Glu Tyr Gly Leu Thr Lys Glu Glu Ala Ala Ser Lys Phe
465                 470                 475                 480 
Glu Gly Leu Val Glu Glu Thr Trp Lys Asp Ile Asn Lys Glu Phe Ile
                485                 490                 495     
Ala Thr Thr Asn Tyr Asn Val Gly Arg Glu Ile Ala Ile Thr Phe Leu
            500                 505                 510         
Asn Tyr Ala Arg Ile Cys Glu Ala Ser Tyr Ser Lys Thr Asp Gly Asp
        515                 520                 525             
Ala Tyr Ser Asp Pro Asn Val Ala Lys Ala Asn Val Val Ala Leu Phe
    530                 535                 540                 
Val Asp Ala Ile Val Phe
545                 550 


<210> 449
<211> 547
<212> PRT
<213> Mikania micrantha

<220> 
<223> beta-caryophyllene synthase Acc. No. ACN67535

<400> 449
Met Gly Cys Lys Gln Glu Ser Phe Arg Pro Phe Arg Ser Thr Ser Pro
 1               5                  10                  15      
Ser Val Trp Gly Asp Met Phe Leu Asn Tyr Glu Lys Lys Ala Glu Gln
            20                  25                  30          
Cys Asp Val Glu Leu Thr Val Glu Asp Leu Lys Glu Lys Val Arg Glu
        35                  40                  45              
Ala Ile Thr Gly Ala Leu Gly Asn Pro Lys Glu His Val Asn Leu Leu
    50                  55                  60                  
Lys Leu Ile Asp Ala Ile Gln Arg Leu Gly Ile Pro Tyr Tyr Phe Glu
65                  70                  75                  80  
Asp Glu Ile Thr Asn Ala Leu Gln His Leu Tyr Glu Ala Tyr Gly Asp
                85                  90                  95      
Glu Trp Val Gly Gly Ser Pro Ser Ile Trp Phe Arg Leu Leu Arg Gln
            100                 105                 110         
His Gly Phe Tyr Val Ser Cys Asp Ile Phe Asn Lys Tyr Tyr Lys Asp
        115                 120                 125             
Lys His Gly Asp Phe Lys Glu Ser Leu Ile Asn Asp Asp Glu Glu Met
    130                 135                 140                 
Val Glu Leu Tyr Glu Ala Thr Ser Leu Arg Val Arg Gly Glu Val Val
145                 150                 155                 160 
Leu Asp Glu Ala Phe Glu Phe Thr Arg Asn His Phe Ala Asn Ile Ala
                165                 170                 175     
Lys Glu Pro Arg Cys Ser Asn Ala Thr Leu Ser Thr His Ile Gln Val
            180                 185                 190         
Ala Leu Glu Thr Pro Leu His Lys Arg Ile Pro Arg Leu Asp Ala Leu
        195                 200                 205             
Arg Tyr Ile Arg Phe Tyr Glu Lys Gln Ala Ser His Asn Glu Ser Leu
    210                 215                 220                 
Leu Lys Leu Ala Lys Leu Gly Phe Asn Leu Leu Gln Ser Leu His Arg
225                 230                 235                 240 
Ser Glu Leu Ser Gln Val Ser Lys Trp Trp Lys Asp Val Asp Val Gln
                245                 250                 255     
Lys Asn Leu Pro Tyr Ala Arg Asp Arg Met Val Glu Ser Tyr Phe Trp
            260                 265                 270         
Ala Ile Gly Val Tyr Ser Glu Pro Lys Tyr Ser Leu Gly Arg Val Phe
        275                 280                 285             
Leu Ala Lys Val Ile Gln Leu Ala Thr Ala Ile Asp Asp Thr Phe Asp
    290                 295                 300                 
Ala Tyr Gly Thr Tyr Glu Glu Leu Gln Thr Phe Thr Arg Ala Val Glu
305                 310                 315                 320 
Arg Trp Ser Ile Thr Cys Leu Asp Glu Leu Pro Glu Tyr Met Lys Leu
                325                 330                 335     
Leu Tyr Gln Val Leu Leu Asp Leu Tyr Gly Glu Met Glu Pro Ile Met
            340                 345                 350         
Glu Lys Glu Gln Leu Thr Pro Leu Phe Asn Cys Ser Lys Glu Phe Met
        355                 360                 365             
Ile Glu Thr Val Lys Ala Tyr Met Val Glu Ala Lys Trp Val Tyr Glu
    370                 375                 380                 
Gly His Ile Pro Thr Lys Asp Glu His Thr Ser Ile Ala Phe Ala Thr
385                 390                 395                 400 
Gly Gly Gly Pro Leu Leu Met Ser Ser Cys Tyr Leu Gly Met Gly Asp
                405                 410                 415     
Ile Ile Thr Asn Asp Ser Ile Asn Trp Val Ile Ser Glu Pro Pro Leu
            420                 425                 430         
Leu Lys Ala Thr Asn Met Ile Gly Arg Leu Leu Asn Asp Ile Val Ser
        435                 440                 445             
Ser Lys Lys Glu Gln Glu Arg Val His Phe Gln Ser Ile Val Gln Cys
    450                 455                 460                 
Tyr Lys Lys Gln Tyr Asp Val Ser Glu Glu His Ala Ile Asn Leu Val
465                 470                 475                 480 
Arg Glu Glu Ile Glu Asp Val Trp Lys Asp Ile Asn Lys Asp Ser Leu
                485                 490                 495     
Thr Ala Lys Asp Val Pro Arg Pro Leu Ile Leu Val Val Val Asn Tyr
            500                 505                 510         
Ala Arg Thr Leu Tyr Tyr Leu Tyr Lys Tyr Asn Asp Asn Phe Phe Glu
        515                 520                 525             
Val Glu Glu Asp Ile Lys Glu Asp Ile Lys Ser Leu Leu Ile His Pro
    530                 535                 540                 
Met Ser Ile
545         


<210> 450
<211> 548
<212> PRT
<213> Nicotiana attenuata

<220> 
<223> 5-epi-aristolochene synthase Acc. No. AAO85555

<400> 450
Met Ala Ser Ala Ala Val Gly Asn Tyr Glu Glu Glu Ile Val Arg Pro
 1               5                  10                  15      
Val Ala Asp Phe Ser Pro Ser Leu Trp Gly Asp His Phe Leu Ser Phe
            20                  25                  30          
Ser Ile Asp Asn His Val Ala Gln Lys Tyr Ala Gln Glu Ile Glu Pro
        35                  40                  45              
Leu Lys Glu Gln Thr Arg Ser Met Leu Val Ala Thr Gly Arg Lys Leu
    50                  55                  60                  
Val Asp Thr Leu Asn Leu Ile Asp Thr Ile Glu Arg Leu Gly Ile Ser
65                  70                  75                  80  
Tyr His Phe Glu Lys Glu Ile Asp Glu Ile Leu Asp Gln Ile Tyr Asn
                85                  90                  95      
Gln Asn Ser Asn Ser Ser Asp Leu Phe Thr Ser Ala Leu Leu Phe Arg
            100                 105                 110         
Leu Leu Arg Gln His Gly Phe Asn Ile Ser Pro Glu Ile Phe Ser Lys
        115                 120                 125             
Phe Gln Asp Glu Asn Gly Lys Phe Lys Glu Ser Leu Ala Ser Asp Val
    130                 135                 140                 
Val Gly Leu Leu Asn Leu Tyr Glu Ala Ser His Val Arg Thr His Ala
145                 150                 155                 160 
Asp Asp Ile Leu Glu Ala Ala Leu Ala Phe Ser Thr Ile His Leu Glu
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Arg Glu Gln Val Ala His
            180                 185                 190         
Ala Leu Glu Gln Cys Leu His Lys Gly Val Pro Arg Val Glu Thr Arg
        195                 200                 205             
Phe Phe Ile Ser Ser Ile Tyr Glu Lys Glu Gln Ser Lys Asn Asn Val
    210                 215                 220                 
Leu Leu Arg Phe Ala Ile Leu Asp Phe Asn Leu Leu Gln Met Leu His
225                 230                 235                 240 
Lys Gln Glu Leu Ala Glu Val Ser Arg Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Val Thr Thr Leu Pro Tyr Ala Arg Asp Arg Val Val Glu Cys Tyr Phe
            260                 265                 270         
Trp Ala Leu Gly Val Tyr Phe Glu Pro Gln Tyr Ser Gln Ala Arg Val
        275                 280                 285             
Met Leu Val Lys Thr Ile Ser Met Ile Ser Ile Val Asp Asp Thr Phe
    290                 295                 300                 
Asp Ala Tyr Gly Thr Val Lys Glu Leu Glu Thr Tyr Thr Asp Ala Ile
305                 310                 315                 320 
Gln Arg Trp Asp Ile Asn Glu Ile Asp Arg Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Ile Ser Tyr Lys Ala Ile Leu Asp Leu Tyr Lys Asp Tyr Glu Lys Glu
            340                 345                 350         
Leu Ser Ser Ala Gly Arg Ser His Ile Val Cys His Ala Ile Glu Arg
        355                 360                 365             
Met Lys Glu Val Val Arg Asn Tyr Asn Val Glu Ser Thr Trp Phe Ile
    370                 375                 380                 
Glu Gly Tyr Met Pro Pro Val Ser Glu Tyr Leu Ser Asn Ala Leu Ala
385                 390                 395                 400 
Thr Thr Thr Tyr Tyr Tyr Leu Ala Thr Thr Ser Tyr Leu Gly Met Lys
                405                 410                 415     
Ser Ala Thr Glu Gln Asp Phe Glu Trp Leu Ser Lys Asn Pro Lys Ile
            420                 425                 430         
Leu Glu Ala Ser Val Ile Ile Cys Arg Val Ile Asp Asp Thr Ala Thr
        435                 440                 445             
Tyr Glu Val Glu Lys Ser Arg Gly Gln Ile Ala Thr Gly Ile Glu Cys
    450                 455                 460                 
Cys Met Arg Asp Tyr Gly Val Ser Thr Lys Glu Ala Met Asp Lys Phe
465                 470                 475                 480 
Gln Gln Met Ala Glu Thr Ala Trp Lys Asp Leu Asn Glu Gly Leu Leu
                485                 490                 495     
Arg Pro Thr Pro Val Ser Ala Glu Leu Leu Thr Pro Ile Leu Asn Leu
            500                 505                 510         
Ala Arg Ile Val Glu Val Thr Tyr Ile His Asn Leu Asp Gly Tyr Thr
        515                 520                 525             
His Pro Glu Lys Val Leu Lys Pro His Ile Ile Gly Leu Leu Val Asp
    530                 535                 540                 
Ser Ile Asp Ile
545             


<210> 451
<211> 546
<212> PRT
<213> Ocimum basilicum

<220> 
<223> germacrene D synthase Acc. No. AAV63786

<400> 451
Met Thr Asn Met Phe Ala Ser Ala Ala Pro Ile Ser Thr Asn Asn Thr
 1               5                  10                  15      
Thr Val Glu Asp Met Arg Arg Ser Val Thr Tyr His Pro Ser Val Trp
            20                  25                  30          
Lys Asp His Phe Leu Asp Tyr Ala Ser Gly Ile Thr Glu Val Glu Met
        35                  40                  45              
Glu Gln Leu Gln Lys Gln Lys Glu Arg Ile Lys Thr Leu Leu Ala Gln
    50                  55                  60                  
Thr Leu Asp Asp Phe Val Leu Lys Ile Glu Leu Ile Asp Ala Ile Gln
65                  70                  75                  80  
Arg Leu Gly Val Gly Tyr His Phe Glu Lys Glu Ile Asn His Ser Leu
                85                  90                  95      
Arg Gln Ile Tyr Asp Thr Phe Gln Ile Ser Ser Lys Asp Asn Asp Ile
            100                 105                 110         
Arg Val Val Ala Leu Arg Phe Arg Leu Leu Arg Gln His Gly Tyr Pro
        115                 120                 125             
Val Pro Ser Asp Val Phe Lys Lys Phe Ile Asp Asn Gln Gly Arg Leu
    130                 135                 140                 
Asp Glu Ser Val Met Asn Asn Val Glu Gly Met Leu Ser Leu Tyr Glu
145                 150                 155                 160 
Ala Ser Asn Tyr Gly Met Glu Gly Glu Asp Ile Leu Asp Lys Ala Leu
                165                 170                 175     
Glu Ile Ser Thr Ser His Leu Glu Pro Leu Ala Ser Arg Ser Arg Arg
            180                 185                 190         
Ile Asn Glu Ala Leu Glu Met Pro Ile Ser Lys Thr Leu Val Arg Leu
        195                 200                 205             
Gly Ala Arg Lys Phe Ile Ser Ile Tyr Glu Glu Asp Glu Ser Arg Asp
    210                 215                 220                 
Glu Asp Leu Leu Lys Phe Ala Lys Leu Asp Phe Asn Ile Leu Gln Lys
225                 230                 235                 240 
Ile His Gln Glu Glu Leu Thr His Ile Ala Arg Trp Trp Lys Glu Leu
                245                 250                 255     
Asp Leu Gly Asn Lys Leu Pro Phe Ala Arg Asp Arg Val Val Glu Cys
            260                 265                 270         
Tyr Phe Trp Ile Leu Gly Val Tyr Phe Glu Pro Gln Tyr Asn Ile Ala
        275                 280                 285             
Arg Arg Phe Met Thr Lys Val Ile Ala Met Thr Ser Ile Ile Asp Asp
    290                 295                 300                 
Ile Tyr Asp Val His Gly Thr Leu Glu Glu Leu Gln Arg Phe Thr Asp
305                 310                 315                 320 
Ala Ile Arg Ser Trp Asp Ile Arg Ala Ile Asp Glu Leu Pro Pro Tyr
                325                 330                 335     
Met Arg Leu Cys Tyr Glu Ala Leu Leu Gly Met Tyr Ala Glu Met Glu
            340                 345                 350         
Asn Glu Met Val Lys Gln Asn Gln Ser Tyr Arg Ile Glu Tyr Ala Arg
        355                 360                 365             
Gln Glu Met Ile Lys Leu Val Thr Thr Tyr Met Glu Glu Ala Lys Trp
    370                 375                 380                 
Cys Tyr Ser Lys Tyr Ile Pro Asn Met Asp Glu Tyr Met Lys Leu Ala
385                 390                 395                 400 
Leu Val Ser Gly Ala Tyr Met Met Leu Ala Thr Thr Ser Leu Val Gly
                405                 410                 415     
Ile Leu Gly Asp Pro Ile Thr Lys Gln Asp Phe Asp Trp Ile Thr Asn
            420                 425                 430         
Glu Pro Pro Ile Leu Arg Ala Ala Ser Val Ile Cys Arg Leu Met Asp
        435                 440                 445             
Asp Val Val Gly His Gly Ile Glu Gln Lys Ile Ser Ser Val Asp Cys
    450                 455                 460                 
Tyr Met Lys Glu Asn Gly Cys Ser Lys Met Glu Ala Val Gly Glu Phe
465                 470                 475                 480 
Ser Lys Arg Val Lys Lys Ala Trp Lys Asn Leu Asn Glu Glu Trp Val
                485                 490                 495     
Glu Pro Arg Ala Ala Ser Met Val Ile Leu Val Arg Val Val Asn Leu
            500                 505                 510         
Ala Arg Val Ile Asn Leu Leu Tyr Val Gly Glu Asp Ser Tyr Gly Asn
        515                 520                 525             
Ser Ser Val Lys Thr Lys Glu Leu Ile Lys Gly Val Leu Val His Pro
    530                 535                 540                 
Ile Lys
545     


<210> 452
<211> 541
<212> PRT
<213> Ocimum basilicum

<220> 
<223> alpha-zingiberene synthase Acc. No. AAV63788

<400> 452
Met Glu Ser Arg Arg Ser Ala Asn Tyr Gln Ala Ser Ile Trp Asp Asp
 1               5                  10                  15      
Asn Phe Ile Gln Ser Leu Ala Ser Pro Tyr Ala Gly Glu Lys Tyr Ala
            20                  25                  30          
Glu Lys Ala Glu Lys Leu Lys Thr Glu Val Lys Thr Met Ile Asp Gln
        35                  40                  45              
Thr Arg Asp Glu Leu Lys Gln Leu Glu Leu Ile Asp Asn Leu Gln Arg
    50                  55                  60                  
Leu Gly Ile Cys His His Phe Gln Asp Leu Thr Lys Lys Ile Leu Gln
65                  70                  75                  80  
Lys Ile Tyr Gly Glu Glu Arg Asn Gly Asp His Gln His Tyr Lys Glu
                85                  90                  95      
Lys Gly Leu His Phe Thr Ala Leu Arg Phe Arg Ile Leu Arg Gln Asp
            100                 105                 110         
Gly Tyr His Val Pro Gln Asp Val Phe Ser Ser Phe Met Asn Lys Ala
        115                 120                 125             
Gly Asp Phe Glu Glu Ser Leu Ser Lys Asp Thr Lys Gly Leu Val Ser
    130                 135                 140                 
Leu Tyr Glu Ala Ser Tyr Leu Ser Met Glu Gly Glu Thr Ile Leu Asp
145                 150                 155                 160 
Met Ala Lys Asp Phe Ser Ser His His Leu His Lys Met Val Glu Asp
                165                 170                 175     
Ala Thr Asp Lys Arg Val Ala Asn Gln Ile Ile His Ser Leu Glu Met
            180                 185                 190         
Pro Leu His Arg Arg Val Gln Lys Leu Glu Ala Ile Trp Phe Ile Gln
        195                 200                 205             
Phe Tyr Glu Cys Gly Ser Asp Ala Asn Pro Thr Leu Val Glu Leu Ala
    210                 215                 220                 
Lys Leu Asp Phe Asn Met Val Gln Ala Thr Tyr Gln Glu Glu Leu Lys
225                 230                 235                 240 
Arg Leu Ser Arg Trp Tyr Glu Glu Thr Gly Leu Gln Glu Lys Leu Ser
                245                 250                 255     
Phe Ala Arg His Arg Leu Ala Glu Ala Phe Leu Trp Ser Met Gly Ile
            260                 265                 270         
Ile Pro Glu Gly His Phe Gly Tyr Gly Arg Met His Leu Met Lys Ile
        275                 280                 285             
Gly Ala Tyr Ile Thr Leu Leu Asp Asp Ile Tyr Asp Val Tyr Gly Thr
    290                 295                 300                 
Leu Glu Glu Leu Gln Val Leu Thr Glu Ile Ile Glu Arg Trp Asp Ile
305                 310                 315                 320 
Asn Leu Leu Asp Gln Leu Pro Glu Tyr Met Gln Ile Phe Phe Leu Tyr
                325                 330                 335     
Met Phe Asn Ser Thr Asn Glu Leu Ala Tyr Glu Ile Leu Arg Asp Gln
            340                 345                 350         
Gly Ile Asn Val Ile Ser Asn Leu Lys Gly Leu Trp Val Glu Leu Ser
        355                 360                 365             
Gln Cys Tyr Phe Lys Glu Ala Thr Trp Phe His Asn Gly Tyr Thr Pro
    370                 375                 380                 
Thr Thr Glu Glu Tyr Leu Asn Val Ala Cys Ile Ser Ala Ser Gly Pro
385                 390                 395                 400 
Val Ile Leu Phe Ser Gly Tyr Phe Thr Thr Thr Asn Pro Ile Asn Lys
                405                 410                 415     
His Glu Leu Gln Ser Leu Glu Arg His Ala His Ser Leu Ser Met Ile
            420                 425                 430         
Leu Arg Leu Ala Asp Asp Leu Gly Thr Ser Ser Asp Glu Met Lys Arg
        435                 440                 445             
Gly Asp Val Pro Lys Ala Ile Gln Cys Phe Met Asn Asp Thr Gly Cys
    450                 455                 460                 
Cys Glu Glu Glu Ala Arg Gln His Val Lys Arg Leu Ile Asp Ala Glu
465                 470                 475                 480 
Trp Lys Lys Met Asn Lys Asp Ile Leu Met Glu Lys Pro Phe Lys Asn
                485                 490                 495     
Phe Cys Pro Thr Ala Met Asn Leu Gly Arg Ile Ser Met Ser Phe Tyr
            500                 505                 510         
Glu His Gly Asp Gly Tyr Gly Gly Pro His Ser Asp Thr Lys Lys Lys
        515                 520                 525             
Met Val Ser Leu Phe Val Gln Pro Met Asn Ile Thr Ile
    530                 535                 540     


<210> 453
<211> 550
<212> PRT
<213> Ocimum basilicum

<220> 
<223> beta-selinene synthase Acc. No. AAV63785

<400> 453
Met Ser Ala Asn Cys Val Ser Ala Ala Pro Thr Ser Pro Lys Asn Ser
 1               5                  10                  15      
Asp Val Glu Glu Ile Arg Lys Ser Ala Thr Tyr His Ser Ser Val Trp
            20                  25                  30          
Gly Asn His Phe Leu Ser Tyr Thr Ser Asp Val Thr Glu Ile Thr Ala
        35                  40                  45              
Ala Glu Lys Glu Gln Leu Glu Lys Leu Lys Glu Lys Val Lys Asn Leu
    50                  55                  60                  
Leu Ala Gln Thr Pro Asp Glu Ser Thr Gly Lys Met Glu Leu Ile Asp
65                  70                  75                  80  
Ala Ile Gln Arg Leu Gly Val Gly Tyr His Phe Thr Thr Glu Ile Gln
                85                  90                  95      
Glu Ser Leu Arg Gln Ile His Glu Gly Gln Ile Arg Asn Asp Asp Asp
            100                 105                 110         
Asp Val Arg Val Val Ala Leu Arg Phe Arg Leu Leu Arg Gln Gly Gly
        115                 120                 125             
Tyr Arg Ala Pro Cys Asp Val Phe Glu Lys Phe Met Asp Asp Gly Gly
    130                 135                 140                 
Asn Phe Lys Glu Ser Leu Lys Lys Asp Val Glu Gly Met Leu Ser Leu
145                 150                 155                 160 
Tyr Glu Ala Ser Tyr Tyr Gly Ile Asp Gly Glu Glu Ile Met Asp Lys
                165                 170                 175     
Ala Leu Glu Phe Ser Ser Ser His Leu Glu Ser Met Leu His Asn Ile
            180                 185                 190         
Ser Thr Lys Thr Asn Lys Ser Leu Leu Arg Arg Leu Gln Glu Ala Leu
        195                 200                 205             
Asp Thr Pro Ile Ser Lys Ala Ala Ile Arg Leu Gly Ala Thr Lys Phe
    210                 215                 220                 
Ile Ser Thr Tyr Arg Glu Asp Glu Ser His Asn Glu Asp Ile Leu Asn
225                 230                 235                 240 
Phe Ala Lys Leu Asp Phe Asn Ile Leu Gln Lys Met His Gln Glu Glu
                245                 250                 255     
Ala Asn Tyr Leu Thr Arg Trp Trp Glu Asp Leu Asp Leu Ala Ser Lys
            260                 265                 270         
Leu Asp Phe Ala Arg Asp Arg Met Val Glu Ser Tyr Phe Trp Ser Leu
        275                 280                 285             
Gly Val Tyr Phe Gln Pro Gln Tyr Arg Thr Ser Arg Ile Tyr Leu Thr
    290                 295                 300                 
Lys Ile Ile Ser Ile Val Ala Val Ile Asp Asp Ile Tyr Asp Val Tyr
305                 310                 315                 320 
Gly Ser Phe Asp Asp Leu Arg Ser Phe Thr Asp Val Ile Gln Ser Trp
                325                 330                 335     
Lys Ile Ser Asn Ala Asp Glu Leu Pro Pro Tyr Met Arg Ile Cys Phe
            340                 345                 350         
Glu Ala Leu Leu Gly Ile Tyr Glu Asp Met Gly Asp Arg Ile Gly Ala
        355                 360                 365             
Pro Tyr Ala Ile Asp Thr Met Lys Glu Leu Val Asp Thr Tyr Met Gln
    370                 375                 380                 
Glu Ala Glu Trp Cys Tyr Thr Glu Tyr Val Pro Thr Val Asp Glu Tyr
385                 390                 395                 400 
Met Lys Val Ala Leu Val Thr Gly Gly Tyr Leu Met Val Ala Thr Thr
                405                 410                 415     
Phe Leu Thr Gly Ile Asn Asn Ile Thr Lys Lys Asp Phe Asp Trp Ile
            420                 425                 430         
Arg Asn Arg Pro Arg Leu Leu Gln Val Ala Glu Val Leu Thr Arg Leu
        435                 440                 445             
Met Asp Asp Ile Ala Gly His Gly Thr Glu Lys Lys Thr Thr Ala Val
    450                 455                 460                 
Ser Cys Tyr Met Lys Glu Tyr Glu Cys Ser Glu Met Glu Ala Ser Arg
465                 470                 475                 480 
Glu Leu Ser Lys Gln Val Lys Lys Ala Trp Lys Asp Leu Asn Asp Glu
                485                 490                 495     
Trp Met Glu Pro Arg Ser Ser Ser Ala Glu Ile Ile Gly Cys Ile Val
            500                 505                 510         
Asn Met Ser Arg Val Leu His Ile Met Tyr Ser Thr Gly Asp Asp Gly
        515                 520                 525             
Phe Ser Asp Ser Ser Thr Arg Thr Thr Gln Ala Val Lys Thr Leu Leu
    530                 535                 540                 
Val Asp His Pro Met Asn
545                 550 


<210> 454
<211> 540
<212> PRT
<213> Ocimum basilicum

<220> 
<223> delta-cadinene synthase Acc. No. Q5SBP5

<400> 454
Met Asp Val Ser Ile Leu Arg Asp Val Arg Pro Pro Val Thr Ser Tyr
 1               5                  10                  15      
Ala Pro Asn Ile Trp Ala Asp Thr Phe Ser Asn Ile Ser Leu Asp Glu
            20                  25                  30          
Glu Val Gln Lys Lys Tyr Ala Glu Thr Ile Glu Ala Leu Lys Gln Val
        35                  40                  45              
Val Arg Gly Met Leu Met Ala Ala Ala Thr Pro Ile Lys Gln Met Ile
    50                  55                  60                  
Phe Ile Asp Thr Leu Glu Arg Leu Gly Leu Ala Tyr His Phe Glu Thr
65                  70                  75                  80  
Glu Ile Glu His Lys Leu Gln Lys Ile Tyr Asp Asp Asn Val Cys Gly
                85                  90                  95      
Asp Asp Cys Asp Leu Phe Thr Thr Ala Leu Arg Phe Arg Leu Leu Arg
            100                 105                 110         
Gln His Arg His His Val Ser Cys Asp Val Phe Asp Lys Phe Leu Tyr
        115                 120                 125             
Glu Glu Gly Lys Phe Lys Gly Asp Ala Glu Gly Leu Leu Ser Leu Tyr
    130                 135                 140                 
Glu Ala Ser His Val Arg Phe His Asn Glu Lys Ile Leu Glu Glu Ala
145                 150                 155                 160 
Glu Arg Phe Thr Arg Gln Glu Leu Ser Cys Trp Ile Lys Leu Gln Ser
                165                 170                 175     
Pro Leu Lys Asp Lys Val Lys Arg Ala Leu Glu Arg Pro Leu His Arg
            180                 185                 190         
Glu Val Pro Ile Leu Tyr Ala Arg His Phe Ile Ser Ile Tyr Glu Lys
        195                 200                 205             
Asp Glu Ser Met Asp Glu His Leu Leu Lys Leu Ala Lys Phe Asn Phe
    210                 215                 220                 
Asn Phe Leu Gln Asn Leu Tyr Lys Lys Glu Leu Tyr Asp Leu Ser Arg
225                 230                 235                 240 
Trp Trp Asn Lys Phe Asp Leu Lys Thr Lys Leu Pro Tyr Ile Arg Asp
                245                 250                 255     
Arg Leu Ala Glu Ala Tyr Leu Trp Gly Val Gly Tyr His Phe Glu Pro
            260                 265                 270         
Gln Tyr Ser Tyr Val Arg Lys Gly Val Val Leu Ser Ile Lys Ile Ile
        275                 280                 285             
Gly Ile Leu Asp Asp Thr Tyr Asp Asn Tyr Ala Thr Val Asn Glu Ala
    290                 295                 300                 
Gln Leu Phe Thr Glu Ile Leu Asp Arg Trp Ser Met Asp Glu Ile Asp
305                 310                 315                 320 
Arg Leu Pro Asp Tyr Met Lys Ile Val Leu His Phe Val Met Ser Ala
                325                 330                 335     
Tyr Glu Glu Tyr Glu Arg Asp Ala Lys Ile Val Tyr Gly Lys Lys Phe
            340                 345                 350         
Ala Ser Pro Tyr Phe Lys Glu Thr Ile Gln Gln Leu Ala Arg Gly Tyr
        355                 360                 365             
Asn Gln Glu Leu Lys Trp Val Met Glu Lys Gln Met Pro Pro Phe Lys
    370                 375                 380                 
Asp Tyr Leu Lys Asn Ser Glu Ile Thr Ser Cys Ile Tyr Ile Met Phe
385                 390                 395                 400 
Ala Ser Ile Ile Pro Gly Leu Lys Ser Phe Thr Gln Glu Ala Ile Asp
                405                 410                 415     
Trp Ile Lys Asn Glu Pro Asn Phe Ala Val Lys Ala Gly Leu Ile Gly
            420                 425                 430         
Arg Tyr Trp Asp Asp Ile Gly Ser His Lys Arg Glu Ser Lys Gly Gly
        435                 440                 445             
Glu Met Leu Thr Val Met Asp Cys Tyr Met Lys Gln Tyr Ser Val Ser
    450                 455                 460                 
Ile Gln Glu Thr Ile Ser Glu Phe Ala Lys Ala Val Glu Asp Ser Trp
465                 470                 475                 480 
Lys Glu Val Asn Glu Gly Trp Val Tyr Thr Ile Ser Met Ser Lys Glu
                485                 490                 495     
Ile Thr Val Gln Phe Leu Asn Tyr Ser Arg Met Cys Asp Ala Ser Tyr
            500                 505                 510         
Asn Arg Asn Asn Gly Asp Gly Tyr Thr Asp Pro Ser Phe Ala Lys Ser
        515                 520                 525             
Asn Ile Thr Ala Leu Phe Val Asp Pro Ile Ile Ile
    530                 535                 540 


<210> 455
<211> 576
<212> PRT
<213> Oryza sativa

<220> 
<223> (E)-beta-caryophyllene synthase Acc. No. ACF05531

<400> 455
Met Ala Thr Ser Val Pro Ser Val Leu Leu Leu Pro Val Pro Thr Cys
 1               5                  10                  15      
Thr Asp Met Leu Val Ser Pro Val Glu Gly Gly Asp Leu Leu His Cys
            20                  25                  30          
Lys Pro His Phe Asp His His Pro Asn Val Trp Gly Asp Tyr Phe Leu
        35                  40                  45              
Thr Phe Ser Pro Cys Thr Pro Ser Met Leu Leu Asn Met Lys Arg Lys
    50                  55                  60                  
Ala His Val Ser Glu Glu Gln Val Arg Arg Met Ile Leu Glu Cys Ser
65                  70                  75                  80  
Ser Gly Pro Asn Leu His Val Lys Leu Glu Leu Val Asp Thr Leu Glu
                85                  90                  95      
Arg Leu Cys Ile Asp Tyr His Tyr Glu Lys Glu Ile Glu Asn Val Leu
            100                 105                 110         
Arg Arg Val His Glu Glu Glu Asp Asp Thr Asp Asn His Tyr Asp Leu
        115                 120                 125             
His Thr Thr Ala Leu Arg Phe Tyr Leu Leu Arg Lys His Gly Tyr Tyr
    130                 135                 140                 
Ala Ser Pro Asp Val Phe Gln Arg Phe Arg Asp Glu Glu Gly Asn Phe
145                 150                 155                 160 
Thr Arg Asp Asp Asn Asn Asn Gly Thr Arg Ser Met Leu Ser Leu Tyr
                165                 170                 175     
Asn Ala Ala His Leu Arg Ile His Gly Glu Glu Ile Leu Asp Asp Ala
            180                 185                 190         
Ile Val Phe Thr Arg Asn Tyr Leu Gln Ser Val Val Lys His Leu Gln
        195                 200                 205             
Ser Pro Met Ala Asp Glu Val Cys Ser Ala Leu Arg Thr Pro Leu Phe
    210                 215                 220                 
Arg Arg Pro Arg Arg Val Glu Ala Arg His Tyr Ile Ser Val Tyr Asp
225                 230                 235                 240 
Lys Leu Pro Thr Arg Asn Glu Thr Ile Leu Glu Phe Ala Lys Leu Asp
                245                 250                 255     
Phe Gly Ile Leu Gln Ser Leu Tyr Cys Glu Glu Leu Asn Ile Leu Thr
            260                 265                 270         
Met Trp Trp Lys Glu Leu Gln Leu Gln Asp His Leu Ser Phe Ala Arg
        275                 280                 285             
Asp Arg Met Val Glu Met His Phe Trp Met Leu Gly Val Leu Phe Glu
    290                 295                 300                 
Pro Gln Tyr Ser Tyr Gly Arg Thr Met Leu Thr Lys Leu Phe Ile Phe
305                 310                 315                 320 
Val Ser Ile Phe Asp Asp Ile Tyr Asp Asn Tyr Ser Thr Leu Glu Glu
                325                 330                 335     
Ser Lys Leu Phe Thr Glu Ala Ile Glu Arg Trp Asp Glu Glu Ala Ala
            340                 345                 350         
Glu Glu Leu Pro Gly Tyr Met Lys Phe Phe Tyr Lys Lys Val Leu Thr
        355                 360                 365             
Thr Met Lys Ser Ile Glu Thr Asp Leu Lys Leu Gln Gly Asn Lys His
    370                 375                 380                 
Val Asp Tyr Val Lys Asn Leu Leu Ile Asp Ala Thr Arg Cys Phe Tyr
385                 390                 395                 400 
Asn Glu Val Lys Trp Arg Ser Glu Gly Ala Asp Gln Val Ala Ala Thr
                405                 410                 415     
Val Glu Glu His Leu Lys Ile Ser Val Pro Ser Ser Cys Cys Met His
            420                 425                 430         
Val Pro Val Tyr Ala Phe Val Ala Met Gly Asn Asp Val Thr Thr Asp
        435                 440                 445             
Asp Ala Ile Asn Trp Gly Met Ala Tyr Pro Lys Ile Ile Thr Ser Ser
    450                 455                 460                 
Cys Ile Val Gly Arg Leu Leu Asn Asp Ile Ala Ser His Glu Arg Glu
465                 470                 475                 480 
Gln Gly Ser Ser Ser Ser Ser Ser Ser Thr Val Glu Ala Cys Met Arg
                485                 490                 495     
Glu His Gly Gly Ile Thr Lys Glu Glu Ala Tyr Ala Lys Leu Arg Glu
            500                 505                 510         
Leu Val Glu Glu Ser Trp Met Asp Ile Ala Gly Glu Cys Leu Arg Pro
        515                 520                 525             
Ala Ala Ala Gln Pro Pro Pro Leu Leu Glu Ala Val Val Asn Ala Thr
    530                 535                 540                 
Arg Val Leu Asp Phe Val Tyr Lys Asp Asp Gln Asp Ala Tyr Thr His
545                 550                 555                 560 
Pro Ser Ser Leu Lys Asp Thr Ile His Ser Ile Tyr Ile Leu Ser Val
                565                 570                 575     


<210> 456
<211> 576
<212> PRT
<213> Oryza sativa

<220> 
<223> (E)-beta-caryophyllene synthase Acc. No. ABJ16553

<400> 456
Met Ala Thr Ser Val Pro Ser Val Leu Leu Leu Pro Val Pro Thr Cys
 1               5                  10                  15      
Thr Asp Met Leu Val Ser Pro Val Glu Gly Gly Asp Leu Leu His Cys
            20                  25                  30          
Lys Pro His Phe Asp His His Pro Asn Val Trp Gly Asp Tyr Phe Leu
        35                  40                  45              
Thr Phe Ser Pro Cys Thr Pro Ser Met Leu Leu Asn Met Lys Arg Lys
    50                  55                  60                  
Ala His Val Ser Glu Glu Gln Val Arg Arg Met Ile Leu Glu Cys Ser
65                  70                  75                  80  
Ser Gly Pro Asn Leu His Val Lys Leu Glu Leu Val Asp Thr Leu Glu
                85                  90                  95      
Arg Leu Cys Ile Asp Tyr His Tyr Glu Lys Glu Ile Glu Asn Val Leu
            100                 105                 110         
Arg Arg Val His Glu Glu Glu Asp Asp Thr Asp Asn His Tyr Asp Leu
        115                 120                 125             
His Thr Thr Ala Leu Arg Phe Tyr Leu Leu Arg Lys His Gly Tyr Tyr
    130                 135                 140                 
Ala Ser Pro Asp Val Phe Gln Arg Phe Arg Asp Glu Glu Gly Asn Phe
145                 150                 155                 160 
Thr Arg Asp Asp Asn Asn Asn Gly Thr Arg Ser Met Leu Ser Leu Tyr
                165                 170                 175     
Asn Ala Ala His Leu Arg Ile His Gly Glu Glu Ile Leu Asp Asp Ala
            180                 185                 190         
Ile Val Phe Thr Arg Asn Tyr Leu Gln Ser Val Val Lys His Leu Gln
        195                 200                 205             
Ser Pro Met Ala Asp Glu Val Cys Ser Ala Leu Arg Thr Pro Leu Phe
    210                 215                 220                 
Arg Arg Pro Arg Arg Val Glu Ala Arg His Tyr Ile Ser Val Tyr Asp
225                 230                 235                 240 
Lys Leu Pro Thr Arg Asn Glu Thr Ile Leu Glu Phe Ala Lys Leu Asp
                245                 250                 255     
Phe Gly Ile Leu Gln Ser Leu Tyr Cys Glu Glu Leu Asn Ile Leu Thr
            260                 265                 270         
Met Trp Trp Lys Glu Leu Gln Leu Gln Asp His Leu Ser Phe Ala Arg
        275                 280                 285             
Asp Arg Met Val Glu Met His Phe Trp Met Leu Gly Val Leu Phe Glu
    290                 295                 300                 
Pro Gln Tyr Ser Tyr Gly Arg Thr Met Leu Thr Lys Leu Phe Ile Phe
305                 310                 315                 320 
Val Ser Ile Phe Asp Asp Ile Tyr Asp Asn Tyr Ser Thr Leu Glu Glu
                325                 330                 335     
Ser Lys Leu Phe Thr Glu Ala Ile Glu Arg Trp Asp Glu Glu Ala Ala
            340                 345                 350         
Glu Glu Leu Pro Gly Tyr Met Lys Phe Phe Tyr Lys Lys Val Leu Thr
        355                 360                 365             
Thr Met Lys Ser Ile Glu Thr Asp Leu Lys Leu Gln Gly Asn Lys His
    370                 375                 380                 
Val Asp Tyr Val Lys Asn Leu Leu Ile Asp Ala Thr Arg Cys Phe Tyr
385                 390                 395                 400 
Asn Glu Val Lys Trp Arg Ser Glu Gly Ala Asp Gln Val Ala Ala Thr
                405                 410                 415     
Val Glu Glu His Leu Lys Ile Ser Val Pro Ser Ser Cys Cys Met His
            420                 425                 430         
Val Pro Val Tyr Ala Phe Val Ala Met Gly Asn Asp Val Thr Thr Asp
        435                 440                 445             
Asp Ala Ile Asn Trp Gly Met Ala Tyr Pro Lys Ile Ile Thr Ser Ser
    450                 455                 460                 
Cys Ile Val Gly Arg Leu Leu Asn Asp Ile Ala Ser His Glu Arg Glu
465                 470                 475                 480 
Gln Gly Ser Ser Ser Ser Ser Ser Ser Thr Val Glu Ala Cys Met Arg
                485                 490                 495     
Glu His Gly Gly Ile Thr Lys Glu Glu Ala Tyr Ala Lys Leu Arg Glu
            500                 505                 510         
Leu Val Glu Glu Ser Trp Met Asp Ile Ala Gly Glu Cys Leu Arg Pro
        515                 520                 525             
Ala Ala Ala Gln Pro Pro Pro Leu Leu Glu Ala Val Val Asn Ala Thr
    530                 535                 540                 
Arg Val Leu Asp Phe Val Tyr Lys Asp Asp Gln Asp Ala Tyr Thr His
545                 550                 555                 560 
Pro Ser Ser Leu Lys Asp Thr Ile His Ser Ile Tyr Ile Leu Ser Val
                565                 570                 575     


<210> 457
<211> 540
<212> PRT
<213> Oryza sativa

<220> 
<223> (E,E)-farnesol synthase Acc. No. ABJ16554

<400> 457
Met Ala Pro Ala Phe His Pro Ala Ile Phe Gly Asp Phe Phe Ile Asn
 1               5                  10                  15      
Asn Val Gln Pro Ser Pro Lys Glu Ser Asp Glu Trp Met Glu Glu Arg
            20                  25                  30          
Val Asp Gln Leu Val Glu Glu Val Gly Arg Met Leu Glu Val Cys Lys
        35                  40                  45              
Asp Asp Val Val Lys Gln Met Asn Leu Val Asp Val Leu Gln Arg Leu
    50                  55                  60                  
Gly Ile Asp His His Phe Glu Glu Gln Ile Asp Thr Ile Leu Lys Asn
65                  70                  75                  80  
Ile His Arg Ala Glu Phe Asn Ser Ser Asp Leu Tyr Glu Val Ala Leu
                85                  90                  95      
Arg Phe Arg Leu Leu Arg Lys Gln Gly Tyr Trp Val Ser Pro Asp Glu
            100                 105                 110         
Phe Asn Lys Phe Lys Ala Glu Asp Gly Ser Phe Ser Ser Asp Asp Ile
        115                 120                 125             
Thr Asn Asp Pro Lys Gly Leu Leu Ser Leu Tyr Asn Ala Ala His Leu
    130                 135                 140                 
Leu Thr His Asn Glu Lys Ala Leu Glu Glu Ala Ile Leu Phe Ala Arg
145                 150                 155                 160 
His His Leu Gln Leu Leu Arg Gly Asn Leu Ala Tyr Pro Leu Asp Glu
                165                 170                 175     
Gln Val Thr Arg Ala Leu Glu Ile Pro Leu Pro Arg Thr Met Lys Arg
            180                 185                 190         
Val Glu Val Leu Asn Tyr Ile Phe Glu Tyr Ser Ala Glu Glu Lys Met
        195                 200                 205             
Phe Asn Pro Ser Ile Leu Glu Leu Ala Val Leu Asp Phe Asn Ile Leu
    210                 215                 220                 
Gln Lys Val His Gln Asn Glu Leu Lys Glu Ile Cys Gln Trp Trp Glu
225                 230                 235                 240 
Asn Leu Ser Ser Asp Ile Arg Leu Asp Tyr Val Arg Glu Arg Val Val
                245                 250                 255     
Glu Cys Tyr Phe Cys Ala Tyr Ala Ala Tyr Tyr Glu Lys Glu His Ala
            260                 265                 270         
Arg Ala Arg Met Ile Phe Ala Lys Arg Cys Met Leu Phe Ser Leu Leu
        275                 280                 285             
Asp Asp Thr Tyr Asp Val Arg Ala Thr Leu Glu Glu Ala Arg Lys Phe
    290                 295                 300                 
Asn Asp Ala Leu Gln Arg Trp Asp Lys Ser Asp Val Ser Leu Leu Pro
305                 310                 315                 320 
Glu Asp Leu Lys Arg Phe Phe Leu Ser Ile Ile Ser Asn Phe Arg Glu
                325                 330                 335     
Phe Glu Asp Glu Leu Glu Pro His Glu Lys Tyr Arg Asn Ser Tyr Asn
            340                 345                 350         
Ile Lys Ala Phe Gln Ile Leu Ser Ser Asn Phe Leu Gln Glu Ala Glu
        355                 360                 365             
Trp Phe His Gln Asn Tyr Ile Pro Cys Phe Thr Asp His Val Thr Val
    370                 375                 380                 
Ser Leu Gln Thr Gly Gly Ala Ile Glu Leu Pro Val Ser Leu Ile Val
385                 390                 395                 400 
Gly Met Gly Asp Ile Ala Thr Lys Glu Val Leu Asp Trp Ala Leu Ala
                405                 410                 415     
Asn Pro Asp Ala Gly Arg Ala Phe Ala Glu Val Ala Arg Phe Met Asp
            420                 425                 430         
Asp Leu Ala Ala Ser His Ser Gly Arg Asp Lys Met Asp Val Ala Ser
        435                 440                 445             
Thr Val Glu Cys Tyr Met Asn Glu His Gly Val Thr Arg Glu Val Ala
    450                 455                 460                 
Glu Ala Lys Ile Ala Gly Met Ala Glu Asp Gly Trp Lys Ser Met Asn
465                 470                 475                 480 
Gln Ile Arg Phe Lys His Arg Ala Phe Leu Pro Phe Val Gln Arg Ile
                485                 490                 495     
Ala Asn Leu Cys Met Ser Ala Thr Leu Leu Tyr His Gly Lys Lys Asn
            500                 505                 510         
Gly Phe Ser Asn Ser Leu Glu Leu Lys Asp Met Phe Glu Ser His Phe
        515                 520                 525             
Val Asn Pro Ile Pro Leu Asn His Ile Asp Tyr Asp
    530                 535                 540 


<210> 458
<211> 546
<212> PRT
<213> Oryza sativa

<220> 
<223> alpha-zingiberene synthase Acc. No. ACF05529

<400> 458
Met Ser Ser Thr Pro Ala Ala Asn Phe Ser Asn Glu Asp Asp Glu Arg
 1               5                  10                  15      
Lys Ala Pro Thr Gly Phe His Pro Ser Leu Trp Gly Asp Phe Phe Ile
            20                  25                  30          
Ser Tyr Gln Pro Pro Thr Ala Pro Lys His Ala Tyr Met Lys Glu Arg
        35                  40                  45              
Ala Glu Val Leu Lys Glu Glu Val Arg Lys Val Val Lys Gly Ser Asn
    50                  55                  60                  
Glu Val Pro Glu Ile Leu Asp Leu Val Ile Thr Leu Gln Arg Leu Gly
65                  70                  75                  80  
Leu Asp Ser Tyr Tyr Lys Ala Glu Ile Asp Glu Leu Leu Cys Thr Val
                85                  90                  95      
Tyr Asn Thr Asp Tyr Asn Asp Lys Asp Leu His Leu Val Ser Leu Arg
            100                 105                 110         
Phe Tyr Leu Leu Arg Lys Asn Gly Tyr Asp Val Ser Ser Asp Ile Phe
        115                 120                 125             
Gln His Phe Lys Asp Lys Glu Gly Ser Phe Val Ala Asp Asp Thr Arg
    130                 135                 140                 
Ser Leu Leu Ser Leu Tyr Asn Ala Ala Tyr Met Arg Thr His Gly Glu
145                 150                 155                 160 
Lys Val Leu Asp Glu Ala Val Val Phe Thr Thr Asn Arg Leu Arg Ser
                165                 170                 175     
Glu Leu Lys His Leu Lys Ser Pro Val Ala Asp Glu Val Ser Leu Ala
            180                 185                 190         
Leu Asp Thr Pro Leu Phe Arg Arg Val Arg Ile Ile Glu Thr Gln Asn
        195                 200                 205             
Tyr Ile Pro Ile Tyr Glu Ser Ala Thr Thr Arg Asn Glu Ala Ile Leu
    210                 215                 220                 
Glu Phe Ala Lys Leu Asn Val Asn Leu Leu Gln Leu Ile Tyr Cys Glu
225                 230                 235                 240 
Glu Leu Lys Thr Ile Thr Arg Trp Trp Lys Glu Leu Asn Val Glu Ser
                245                 250                 255     
Asn Leu Ser Phe Ile Arg Asp Arg Ile Val Glu Met His Phe Trp Met
            260                 265                 270         
Thr Gly Ala Cys Ser Glu Pro His Tyr Ser Leu Leu Arg Ile Ile Leu
        275                 280                 285             
Thr Lys Met Thr Ala Phe Ile Thr Ile Leu Asp Asp Ile Phe Asp Thr
    290                 295                 300                 
Tyr Ala Thr Thr Glu Glu Ser Met Met Leu Ala Lys Ala Ile Tyr Met
305                 310                 315                 320 
Cys Asn Glu Ser Ala Thr Val Leu Leu Pro Lys Tyr Met Lys Asp Phe
                325                 330                 335     
Tyr Leu Tyr Tyr Leu Lys Thr Phe Asp Ser Phe Glu Glu Ala Leu Gly
            340                 345                 350         
Pro Asn Lys Ser Tyr Arg Val Leu Tyr Phe Lys Glu Leu Phe Lys Ile
        355                 360                 365             
Leu Ile Lys Gly Tyr Ser Glu Glu Ile Lys Trp Arg Asp Asp His Tyr
    370                 375                 380                 
Ile Pro Lys Thr Ile Glu Glu His Leu Glu Leu Ser Arg Met Thr Val
385                 390                 395                 400 
Gly Ala Phe Gln Leu Ala Cys Ala Ser Leu Val Gly Met Gly Asp Phe
                405                 410                 415     
Ile Thr Glu Asp Thr Leu Asp Tyr Leu Leu Thr Tyr Pro Lys Leu Ile
            420                 425                 430         
Lys Ser Tyr Thr Thr Cys Val Arg Leu Ser Asn Asp Ile Ala Ser Thr
        435                 440                 445             
Lys Arg Glu Gln Ala Gly Asp His Tyr Ala Ser Thr Ile Gln Cys Tyr
    450                 455                 460                 
Met Leu Gln His Gly Thr Thr Ile His Glu Ala Cys Ile Gly Ile Lys
465                 470                 475                 480 
Glu Leu Ile Glu Asp Ser Trp Lys Asp Met Met Lys Glu Tyr Leu Ala
                485                 490                 495     
Pro Thr Asn Leu Gln Pro Lys Ile Val Ala Arg Thr Val Ile Asp Phe
            500                 505                 510         
Ala Arg Thr Gly Asp Tyr Ile Tyr Lys Gln Ala Asp Ser Phe Thr Phe
        515                 520                 525             
Ser His Thr Ile Lys Asp Met Ile Ala Ser Leu Tyr Val Glu Pro Tyr
    530                 535                 540                 
Ser Ile
545     


<210> 459
<211> 550
<212> PRT
<213> Perilla frutescens var. frutescens

<220> 
<223> sesquiterpene synthase Acc. No. AAX16076

<400> 459
Met Ala Ser Glu Gln Ala Gln Asn His Arg Pro Val Ala Asp Phe Ser
 1               5                  10                  15      
Pro Ser Leu Trp Gly Asp Gln Phe Ile Lys His Asp Ser Cys Pro Gln
            20                  25                  30          
Val Glu Lys Lys Tyr Ser Asn Thr Val Asp Val Leu Lys Lys Glu Val
        35                  40                  45              
Lys Gly Met Ile Thr Ala Pro Gly Thr Lys Met Val Asp Thr Met Glu
    50                  55                  60                  
Leu Ile Asp Thr Ile Glu Arg Leu Gly Val Ser Tyr His Phe Gln Asp
65                  70                  75                  80  
Glu Ile Glu His Lys Leu Gln Gln Phe Phe Asp Leu Lys Pro Asp Tyr
                85                  90                  95      
Cys Asn Asp Asp Asp Asp Ala Tyr Asp Leu His Thr Val Ala Leu His
            100                 105                 110         
Phe Arg Leu Phe Arg Gln His Gly Tyr Arg Ile Ser Cys Asp Ile Phe
        115                 120                 125             
Gly Arg Trp Val His Gly Asp Gly Lys Phe Glu Glu Ile Leu Lys Ser
    130                 135                 140                 
Asp Gly Lys Gly Leu Leu Ser Leu Tyr Glu Ala Ser Tyr Leu Arg Thr
145                 150                 155                 160 
Arg Gly Glu Thr Ile Leu Asp Glu Ala Leu Asp Phe Ala Thr Ala Ser
                165                 170                 175     
Leu Lys Ser Ile Ala Pro Cys Leu Glu Ser Pro Leu Gly Lys Gln Val
            180                 185                 190         
Val His Ala Leu Val Gln Pro Leu His Phe Gly Thr Pro Arg Ile Glu
        195                 200                 205             
Ala Arg Asn Phe Ile Ser Ile Tyr Glu Glu Tyr Glu Gly Arg Asn Glu
    210                 215                 220                 
Ser Leu Leu Met Phe Ala Lys Ile Asp Tyr Asn Leu Leu Gln Met Leu
225                 230                 235                 240 
His Lys Glu Glu Leu His Gln Val Ser Arg Trp Trp Lys Glu Leu Asp
                245                 250                 255     
Leu Ile Ala Lys Leu Pro Tyr Ala Arg Asp Arg Val Val Glu Cys Phe
            260                 265                 270         
Phe Trp Ala Ile Gly Ala Tyr His Glu Pro Gln Tyr Ser Arg Ala Arg
        275                 280                 285             
Val Met Leu Thr Lys Thr Ile Ala Met Thr Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Ile Lys Glu Leu Asp Ile Phe Thr Glu Ala
305                 310                 315                 320 
Ile Glu Arg Trp Asn Val Lys Glu Thr Lys Arg Leu Pro Glu Tyr Met
                325                 330                 335     
Lys Pro Leu Tyr Lys Ala Leu Leu Glu Leu Tyr Gln Gln Phe Glu Gln
            340                 345                 350         
Glu Leu Glu Asn Glu Gly Arg Ser Tyr Val Ala Tyr Tyr Ala Ile Glu
        355                 360                 365             
Ser Leu Lys Glu Leu Val Arg Ser Tyr Arg Val Glu Ala Lys Trp Phe
    370                 375                 380                 
Ile Gln Gly Tyr Leu Pro Pro Phe Glu Glu Tyr Leu Lys Asn Ala Leu
385                 390                 395                 400 
Ile Thr Cys Ser Tyr Cys Tyr His Thr Met Thr Ser Phe Leu Gly Val
                405                 410                 415     
Glu Ser Ala Ile Lys Glu Asp Phe Glu Trp Leu Ser Asn Lys Pro Lys
            420                 425                 430         
Met Leu Val Ala Gly Leu Leu Ile Cys Arg Leu Val Asp Asp Ile Ala
        435                 440                 445             
Thr Tyr Glu Val Glu Lys Ala Arg Gly Gln Val Ala Thr Gly Ile Glu
    450                 455                 460                 
Ser Tyr Met Lys Asp Asn Gly Ala Thr Lys Glu Glu Ala Met Ala Lys
465                 470                 475                 480 
Phe Phe Glu Ile Ala Arg Asp Ala Trp Lys Asp Ile Asn Glu Glu Cys
                485                 490                 495     
Leu Arg Pro Asn Leu Tyr Asn Ser Arg Asp Val Trp Met Arg Ile Leu
            500                 505                 510         
Asn Leu Glu Arg Ile Ile His Val Ala Tyr Lys Asp Ser Gln Asp Gly
        515                 520                 525             
Tyr Thr Gln Pro Glu Lys Val Leu Lys Pro His Ile Ile Ala Leu Phe
    530                 535                 540                 
Val Asp Pro Ile Gln Ile
545                 550 


<210> 460
<211> 550
<212> PRT
<213> Perilla frutescens var. frutescens

<220> 
<223> valencene synthase Acc. No. AAX16077

<400> 460
Met Ala Ser Glu Gln Ala Gln Asn His Arg Pro Val Ala Asp Phe Ser
 1               5                  10                  15      
Pro Ser Leu Trp Gly Asp Gln Phe Val Lys Tyr Asp Ser Cys Pro Gln
            20                  25                  30          
Val Gln Lys Lys Tyr Ser Asn Thr Val Asp Val Leu Lys Lys Glu Val
        35                  40                  45              
Lys Gly Met Ile Thr Ala Pro Gly Thr Lys Met Val Asp Thr Met Glu
    50                  55                  60                  
Leu Ile Asp Thr Ile Glu Arg Leu Gly Val Ser Phe His Phe Gln Asp
65                  70                  75                  80  
Glu Ile Glu Gln Lys Leu Gln Gln Phe Phe Asp Leu Lys Thr Asp Tyr
                85                  90                  95      
Cys Asn Asp Gly Asp Asp Ala Tyr Asp Leu Tyr Thr Val Ala Leu His
            100                 105                 110         
Phe Arg Leu Phe Arg Gln His Gly Tyr Arg Ile Ser Cys Asp Ile Phe
        115                 120                 125             
Gly Arg Trp Ile Asp Gly Asn Gly Lys Phe Lys Glu Gly Leu Lys Ser
    130                 135                 140                 
Asp Gly Lys Ser Leu Leu Ser Leu Tyr Glu Ala Ser Tyr Leu Arg Thr
145                 150                 155                 160 
Arg Gly Glu Thr Ile Leu Asp Glu Ala Leu Asp Phe Ala Ala Ala Ser
                165                 170                 175     
Leu Lys Ser Ile Ala Pro His Leu Gln Ser Pro Leu Gly Lys Gln Val
            180                 185                 190         
Val His Ala Leu Val Gln Pro Leu His Phe Gly Asn Pro Arg Ile Glu
        195                 200                 205             
Ala Arg Asn Phe Ile Ser Ile Tyr Glu Glu Tyr Glu Gly Met Asn Glu
    210                 215                 220                 
Ala Leu Leu Arg Leu Ala Lys Leu Asp Tyr Asn Leu Leu Gln Met Leu
225                 230                 235                 240 
His Lys Glu Glu Leu His Gln Val Ser Arg Trp Trp Lys Asp Leu Asp
                245                 250                 255     
Leu Ile Thr Lys Leu Pro Tyr Ala Arg Asp Arg Val Val Glu Cys Phe
            260                 265                 270         
Phe Trp Ala Val Gly Val Tyr His Glu Pro Gln Tyr Ser Arg Ala Arg
        275                 280                 285             
Val Met Leu Thr Lys Thr Ile Val Met Thr Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Ile Glu Glu Leu Asp Ile Phe Thr Glu Ala
305                 310                 315                 320 
Ile Glu Arg Trp Asn Val Glu Glu Thr Lys Arg Leu Pro Glu Tyr Met
                325                 330                 335     
Lys Pro Leu Tyr Lys Ala Leu Leu Glu Leu Tyr Lys Gln Phe Glu Gln
            340                 345                 350         
Glu Leu Glu Lys Glu Gly Arg Ser Tyr Val Ala Tyr Tyr Ala Ile Glu
        355                 360                 365             
Ser Leu Lys Glu Leu Val Arg Ser Tyr Arg Ile Glu Ala Lys Trp Phe
    370                 375                 380                 
Ile Gln Gly Tyr Leu Pro Pro Tyr Glu Glu Tyr Leu Lys Asn Ala Leu
385                 390                 395                 400 
Ile Thr Cys Thr Tyr Cys Tyr His Thr Thr Thr Ser Leu Leu Gly Val
                405                 410                 415     
Glu Ser Ala Ile Lys Glu Asn Phe Glu Trp Leu Ser Asn Lys Pro Lys
            420                 425                 430         
Met Leu Val Ala Gly Leu Leu Ile Cys Arg Leu Ile Asp Asp Ile Ala
        435                 440                 445             
Thr Tyr Ile Leu Glu Arg Gly Arg Gly Gln Val Ala Thr Gly Ile Glu
    450                 455                 460                 
Ser Tyr Met Lys Asp Asn Gly Ala Thr Gln Glu Glu Pro Ile Ala Lys
465                 470                 475                 480 
Ile Phe Glu Ile Ala Thr Asp Ala Trp Lys Asp Ile Asn Asp Glu Cys
                485                 490                 495     
Leu Arg Pro Ser Leu Tyr Asn Ser Arg Asp Val Leu Met Arg Ile Phe
            500                 505                 510         
Asn Leu Glu Arg Ile Ile Asp Val Thr Tyr Lys Gly Asn Gln Asp Arg
        515                 520                 525             
Tyr Thr Gln Pro Glu Lys Val Leu Lys Pro His Ile Ile Val Phe Phe
    530                 535                 540                 
Phe Asp Pro Ile Leu Ile
545                 550 


<210> 461
<211> 807
<212> PRT
<213> Picea abies

<220> 
<223> (E)-alpha-bisabolene synthase Acc. No. AAS47689

<400> 461
Met Thr Ser Val Ser Val Glu Ser Gly Thr Val Ser Cys Leu Ser Ser
 1               5                  10                  15      
Asn Asn Leu Ile Arg Arg Thr Ala Asn Pro His Pro Asn Ile Trp Gly
            20                  25                  30          
Tyr Asp Phe Val His Ser Leu Lys Ser Pro Tyr Thr His Asp Ser Ser
        35                  40                  45              
Tyr Arg Glu Arg Ala Glu Thr Leu Ile Ser Glu Ile Lys Val Met Leu
    50                  55                  60                  
Gly Gly Gly Glu Leu Met Met Thr Pro Ser Ala Tyr Asp Thr Ala Trp
65                  70                  75                  80  
Val Ala Arg Val Pro Ser Ile Asp Gly Ser Ala Cys Pro Gln Phe Pro
                85                  90                  95      
Gln Thr Val Glu Trp Ile Leu Lys Asn Gln Leu Lys Asp Gly Ser Trp
            100                 105                 110         
Gly Thr Glu Ser His Phe Leu Leu Ser Asp Arg Leu Leu Ala Thr Leu
        115                 120                 125             
Ser Cys Val Leu Ala Leu Leu Lys Trp Lys Val Ala Asp Val Gln Val
    130                 135                 140                 
Glu Gln Gly Ile Glu Phe Ile Lys Arg Asn Leu Gln Ala Ile Lys Asp
145                 150                 155                 160 
Glu Arg Asp Gln Asp Ser Leu Val Thr Asp Phe Glu Ile Ile Phe Pro
                165                 170                 175     
Ser Leu Leu Lys Glu Ala Gln Ser Leu Asn Leu Gly Leu Pro Tyr Asp
            180                 185                 190         
Leu Pro Tyr Ile Arg Leu Leu Gln Thr Lys Arg Gln Glu Arg Leu Ala
        195                 200                 205             
Asn Leu Ser Met Asp Lys Ile His Gly Gly Thr Leu Leu Ser Ser Leu
    210                 215                 220                 
Glu Gly Ile Gln Asp Ile Val Glu Trp Glu Thr Ile Met Asp Val Gln
225                 230                 235                 240 
Ser Gln Asp Gly Ser Phe Leu Ser Ser Pro Ala Ser Thr Ala Cys Val
                245                 250                 255     
Phe Met His Thr Gly Asp Met Lys Cys Leu Asp Phe Leu Asn Asn Val
            260                 265                 270         
Leu Thr Lys Phe Gly Ser Ser Val Pro Cys Leu Tyr Pro Val Asp Leu
        275                 280                 285             
Leu Glu Arg Leu Leu Ile Val Asp Asn Val Glu Arg Leu Gly Ile Asp
    290                 295                 300                 
Arg His Phe Glu Lys Glu Ile Lys Glu Ala Leu Asp Tyr Val Tyr Arg
305                 310                 315                 320 
His Trp Asn Asp Arg Gly Ile Gly Trp Gly Arg Leu Ser Pro Ile Ala
                325                 330                 335     
Asp Leu Glu Thr Thr Ala Leu Gly Phe Arg Leu Leu Arg Leu His Arg
            340                 345                 350         
Tyr Asn Val Ser Pro Val Val Leu Asp Asn Phe Lys Asp Ala Asp Gly
        355                 360                 365             
Glu Phe Phe Cys Ser Thr Gly Gln Phe Asn Lys Asp Val Ala Ser Met
    370                 375                 380                 
Leu Ser Leu Tyr Arg Ala Ser Gln Leu Ala Phe Pro Glu Glu Ser Ile
385                 390                 395                 400 
Leu Asp Glu Ala Lys Ser Phe Ser Thr Gln Tyr Leu Arg Glu Ala Leu
                405                 410                 415     
Glu Lys Ser Glu Thr Phe Ser Ser Trp Asn His Arg Gln Ser Leu Ser
            420                 425                 430         
Glu Glu Ile Lys Tyr Ala Leu Lys Thr Ser Trp His Ala Ser Val Pro
        435                 440                 445             
Arg Val Glu Ala Lys Arg Tyr Cys Gln Val Tyr Arg Gln Asp Tyr Ala
    450                 455                 460                 
His Leu Ala Lys Ser Val Tyr Lys Leu Pro Lys Val Asn Asn Glu Lys
465                 470                 475                 480 
Ile Leu Glu Leu Ala Lys Leu Asp Phe Asn Ile Ile Gln Ser Ile His
                485                 490                 495     
Gln Lys Glu Met Lys Asn Val Thr Ser Trp Phe Arg Asp Ser Gly Leu
            500                 505                 510         
Pro Leu Phe Thr Phe Ala Arg Glu Arg Pro Leu Glu Phe Tyr Phe Leu
        515                 520                 525             
Ile Ala Gly Gly Thr Tyr Glu Pro Gln Tyr Ala Lys Cys Arg Phe Leu
    530                 535                 540                 
Phe Thr Lys Val Ala Cys Leu Gln Thr Val Leu Asp Asp Met Tyr Asp
545                 550                 555                 560 
Thr Tyr Gly Thr Pro Ser Glu Leu Lys Leu Phe Thr Glu Ala Val Arg
                565                 570                 575     
Arg Trp Asp Leu Ser Phe Thr Glu Asn Leu Pro Asp Tyr Met Lys Leu
            580                 585                 590         
Cys Tyr Lys Ile Tyr Tyr Asp Ile Val His Glu Val Ala Trp Glu Val
        595                 600                 605             
Glu Lys Glu Gln Gly Arg Glu Leu Val Ser Phe Phe Arg Lys Gly Trp
    610                 615                 620                 
Glu Asp Tyr Leu Leu Gly Tyr Tyr Glu Glu Ala Glu Trp Leu Ala Ala
625                 630                 635                 640 
Glu Tyr Val Pro Thr Leu Asp Glu Tyr Ile Lys Asn Gly Ile Thr Ser
                645                 650                 655     
Ile Gly Gln Arg Ile Leu Leu Leu Ser Gly Val Leu Ile Met Glu Gly
            660                 665                 670         
Gln Leu Leu Ser Gln Glu Ala Leu Glu Lys Val Asp Tyr Pro Gly Arg
        675                 680                 685             
Arg Val Leu Thr Glu Leu Asn Ser Leu Ile Ser Arg Leu Ala Asp Asp
    690                 695                 700                 
Thr Lys Thr Tyr Lys Ala Glu Lys Ala Arg Gly Glu Leu Ala Ser Ser
705                 710                 715                 720 
Ile Glu Cys Tyr Met Lys Asp His Pro Gly Cys Gln Glu Glu Glu Ala
                725                 730                 735     
Leu Asn His Ile Tyr Gly Ile Leu Glu Pro Ala Val Lys Glu Leu Thr
            740                 745                 750         
Arg Glu Phe Leu Lys Ala Asp His Val Pro Phe Pro Cys Lys Lys Met
        755                 760                 765             
Leu Phe Asp Glu Thr Arg Val Thr Met Val Ile Phe Lys Asp Gly Asp
    770                 775                 780                 
Gly Phe Gly Ile Ser Lys Leu Glu Val Lys Asp His Ile Lys Glu Cys
785                 790                 795                 800 
Leu Ile Glu Pro Leu Pro Leu
                805         


<210> 462
<211> 580
<212> PRT
<213> Picea abies

<220> 
<223> (E,E)-alpha-farnesene synthase Acc. No. AAS47697

<400> 462
Met Asp Leu Ala Val Glu Ile Ala Met Asp Leu Ala Val Asp Asp Val
 1               5                  10                  15      
Glu Arg Arg Val Gly Asp Tyr His Ser Asn Leu Trp Asp Asp Asp Phe
            20                  25                  30          
Ile Gln Ser Leu Ser Thr Pro Tyr Gly Ala Ser Ser Tyr Arg Glu Arg
        35                  40                  45              
Ala Glu Arg Leu Val Gly Glu Val Lys Glu Met Phe Thr Ser Ile Ser
    50                  55                  60                  
Ile Glu Asp Gly Glu Leu Thr Ser Asp Leu Leu Gln Arg Leu Trp Met
65                  70                  75                  80  
Val Asp Asn Val Glu Arg Leu Gly Ile Ser Arg His Phe Glu Asn Glu
                85                  90                  95      
Ile Lys Ala Ala Ile Asp Tyr Val Tyr Ser Tyr Trp Ser Asp Lys Gly
            100                 105                 110         
Ile Val Arg Gly Arg Asp Ser Ala Val Pro Asp Leu Asn Ser Ile Ala
        115                 120                 125             
Leu Gly Phe Arg Thr Leu Arg Leu His Gly Tyr Thr Val Ser Ser Asp
    130                 135                 140                 
Val Phe Lys Val Phe Gln Asp Arg Lys Gly Glu Phe Ala Cys Ser Ala
145                 150                 155                 160 
Ile Pro Thr Glu Gly Asp Ile Lys Gly Val Leu Asn Leu Leu Arg Ala
                165                 170                 175     
Ser Tyr Ile Ala Phe Pro Gly Glu Lys Val Met Glu Lys Ala Gln Thr
            180                 185                 190         
Phe Ala Ala Thr Tyr Leu Lys Glu Ala Leu Gln Lys Ile Gln Val Ser
        195                 200                 205             
Ser Leu Ser Arg Glu Ile Glu Tyr Val Leu Glu Tyr Gly Trp Leu Thr
    210                 215                 220                 
Asn Phe Pro Arg Leu Glu Ala Arg Asn Tyr Ile Asp Val Phe Gly Glu
225                 230                 235                 240 
Glu Ile Cys Pro Tyr Phe Lys Lys Pro Cys Ile Met Val Asp Lys Leu
                245                 250                 255     
Leu Glu Leu Ala Lys Leu Glu Phe Asn Leu Phe His Ser Leu Gln Gln
            260                 265                 270         
Thr Glu Leu Lys His Val Ser Arg Trp Trp Lys Asp Ser Gly Phe Ser
        275                 280                 285             
Gln Leu Thr Phe Thr Arg His Arg His Val Glu Phe Tyr Thr Leu Ala
    290                 295                 300                 
Ser Cys Ile Ala Ile Glu Pro Lys His Ser Ala Phe Arg Leu Gly Phe
305                 310                 315                 320 
Ala Lys Val Cys Tyr Leu Gly Ile Val Leu Asp Asp Ile Tyr Asp Thr
                325                 330                 335     
Phe Gly Lys Met Lys Glu Leu Glu Leu Phe Thr Ala Ala Ile Lys Arg
            340                 345                 350         
Trp Asp Pro Ser Thr Thr Glu Cys Leu Pro Glu Tyr Met Lys Gly Val
        355                 360                 365             
Tyr Met Ala Phe Tyr Asn Cys Val Asn Glu Leu Ala Leu Gln Ala Glu
    370                 375                 380                 
Lys Thr Gln Gly Arg Asp Met Leu Asn Tyr Ala Arg Lys Ala Trp Glu
385                 390                 395                 400 
Ala Leu Phe Asp Ala Phe Leu Glu Glu Ala Lys Trp Ile Ser Ser Gly
                405                 410                 415     
Tyr Leu Pro Thr Phe Glu Glu Tyr Leu Glu Asn Gly Lys Val Ser Phe
            420                 425                 430         
Gly Tyr Arg Ala Ala Thr Leu Gln Pro Ile Leu Thr Leu Asp Ile Pro
        435                 440                 445             
Leu Pro Leu His Ile Leu Gln Gln Ile Asp Phe Pro Ser Arg Phe Asn
    450                 455                 460                 
Asp Leu Ala Ser Ser Ile Leu Arg Leu Arg Gly Asp Ile Cys Gly Tyr
465                 470                 475                 480 
Gln Ala Glu Arg Ser Arg Gly Glu Glu Ala Ser Ser Ile Ser Cys Tyr
                485                 490                 495     
Met Lys Asp Asn Pro Gly Ser Thr Glu Glu Asp Ala Leu Ser His Ile
            500                 505                 510         
Asn Ala Met Ile Ser Asp Asn Ile Asn Glu Leu Asn Trp Glu Leu Leu
        515                 520                 525             
Lys Pro Asn Ser Asn Val Pro Ile Ser Ser Lys Lys His Ala Phe Asp
    530                 535                 540                 
Ile Leu Arg Ala Phe Tyr His Leu Tyr Lys Tyr Arg Asp Gly Phe Ser
545                 550                 555                 560 
Ile Ala Lys Ile Glu Thr Lys Asn Leu Val Met Arg Thr Val Leu Glu
                565                 570                 575     
Pro Val Pro Met
            580 


<210> 463
<211> 578
<212> PRT
<213> Picea abies

<220> 
<223> longifolene synthase Acc. No. AAS47695

<400> 463
Met Ala Gln Ile Ser Lys Cys Ser Ser Leu Ser Ala Glu Leu Asn Glu
 1               5                  10                  15      
Ser Ser Ile Ile Ser His His His Gly Asn Leu Trp Asp Asp Asp Phe
            20                  25                  30          
Ile Gln Ser Leu Lys Ser Ser Asn Gly Ala Pro Gln Tyr His Glu Arg
        35                  40                  45              
Ala Ala Lys Leu Val Glu Glu Ile Lys Asn Leu Val Val Ser Glu Met
    50                  55                  60                  
Lys Asp Cys Asn Asp Asp Leu Ile Arg Arg Leu Gln Met Val Asp Ile
65                  70                  75                  80  
Phe Glu Cys Leu Gly Ile Asp Arg His Phe Gln His Glu Ile Gln Val
                85                  90                  95      
Ala Leu Asp Tyr Val Tyr Arg Tyr Trp Asn Gln Leu Glu Gly Ile Gly
            100                 105                 110         
Ile Gly Ser Arg Asp Ser Leu Ile Lys Asp Phe Asn Ala Thr Ala Leu
        115                 120                 125             
Gly Phe Arg Ala Leu Arg Leu His Arg Tyr Asn Val Ser Ser Asp Val
    130                 135                 140                 
Leu Glu Asn Phe Lys Asn Glu Asn Gly Gln Phe Phe Cys Ser Ser Thr
145                 150                 155                 160 
Val Glu Glu Lys Glu Val Arg Cys Met Leu Thr Leu Phe Arg Ala Ser
                165                 170                 175     
Glu Ile Ser Phe Pro Gly Glu Lys Val Met Asp Glu Ala Lys Ala Phe
            180                 185                 190         
Thr Thr Glu Tyr Leu Thr Lys Val Leu Thr Gly Val Asp Val Thr Asp
        195                 200                 205             
Val Asn Gln Ser Leu Leu Arg Glu Val Lys Tyr Ala Leu Glu Phe Pro
    210                 215                 220                 
Trp His Cys Ser Leu Pro Arg Trp Glu Ala Arg Ser Phe Ile Glu Ile
225                 230                 235                 240 
Cys Gly Gln Asn Asp Ser Trp Leu Lys Ser Ile Met Asn Lys Arg Val
                245                 250                 255     
Leu Glu Leu Ala Lys Leu Asp Phe Asn Ile Leu Gln Trp Ala His His
            260                 265                 270         
Arg Glu Leu Gln Leu Leu Ser Ser Trp Trp Ser Gln Ser Asp Ile Ala
        275                 280                 285             
Gln Gln Asn Phe Tyr Arg Lys Arg His Val Glu Phe Tyr Leu Trp Val
    290                 295                 300                 
Val Ile Gly Thr Phe Glu Pro Glu Phe Ser Thr Cys Arg Ile Thr Phe
305                 310                 315                 320 
Ala Lys Ile Ser Thr Leu Met Thr Ile Leu Asp Asp Leu Tyr Asp Thr
                325                 330                 335     
His Gly Thr Leu Glu Gln Leu Lys Ile Phe Thr Glu Gly Val Lys Arg
            340                 345                 350         
Trp Asp Leu Ser Leu Val Asp Arg Leu Pro Asp Tyr Ile Lys Ile Thr
        355                 360                 365             
Phe Glu Phe Phe Leu Asn Thr Ser Asn Glu Leu Ile Ala Glu Val Ala
    370                 375                 380                 
Lys Thr Gln Glu Arg Asp Met Ser Ala Tyr Ile Arg Lys Thr Trp Glu
385                 390                 395                 400 
Arg Tyr Leu Glu Ala Tyr Leu Gln Glu Ala Glu Trp Ile Ala Ala Arg
                405                 410                 415     
His Val Pro Thr Phe Asp Glu Tyr Met Lys Asn Gly Ile Ser Ser Ser
            420                 425                 430         
Gly Met Cys Ile Leu Asn Leu Tyr Ser Leu Leu Leu Met Gly Gln Leu
        435                 440                 445             
Leu Pro Asp Asp Val Leu Glu Gln Ile His Ser Pro Ser Lys Ile His
    450                 455                 460                 
Glu Leu Val Glu Leu Thr Ala Arg Leu Val Asp Asp Ser Lys Asp Phe
465                 470                 475                 480 
Glu Thr Lys Lys Val Gly Gly Glu Leu Ala Ser Gly Ile Glu Cys Tyr
                485                 490                 495     
Val Lys Asp Asn Pro Glu Cys Thr Leu Glu Asp Ala Ser Asn His Leu
            500                 505                 510         
Asn Gly Leu Leu Asp Leu Thr Val Lys Glu Leu Asn Trp Glu Phe Val
        515                 520                 525             
Arg His Asp Ser Val Ala Leu Cys Phe Lys Lys Phe Ala Phe Asn Val
    530                 535                 540                 
Ala Arg Gly Leu Arg Leu Ile Tyr Lys Tyr Arg Asp Gly Phe Asp Val
545                 550                 555                 560 
Ser Asn Gln Glu Met Lys Thr His Ile Phe Lys Ile Leu Ile Asp Pro
                565                 570                 575     
Leu Thr
        


<210> 464
<211> 574
<212> PRT
<213> Pinus taeda

<220> 
<223> (E,E)-alpha-farnesene synthase Acc. No. AAO61266

<400> 464
Met Ser Ser Leu Ala Val Asp Asp Ala Glu Arg Arg Val Gly Asp Tyr
 1               5                  10                  15      
His Pro Asn Leu Trp Asp Asp Ala Leu Ile Gln Ser Leu Ser Thr Pro
            20                  25                  30          
Tyr Gly Ala Ser Pro Tyr Arg Asp Val Ala Glu Lys Leu Ile Gly Glu
        35                  40                  45              
Ile Lys Glu Met Phe Ala Ser Ile Ser Ile Glu Asp Gly Asp Asp Glu
    50                  55                  60                  
Ile Cys Tyr Phe Leu Gln Arg Leu Trp Met Ile Asp Asn Val Glu Arg
65                  70                  75                  80  
Leu Gly Ile Ser Arg His Phe Glu Asn Glu Ile Lys Ala Ala Met Glu
                85                  90                  95      
Asp Val Tyr Ser Arg His Trp Ser Asp Lys Gly Ile Ala Cys Gly Arg
            100                 105                 110         
His Ser Val Val Ala Asp Leu Asn Ser Thr Ala Leu Ala Phe Arg Thr
        115                 120                 125             
Leu Arg Leu His Gly Tyr Ser Val Cys Ser Asp Val Phe Lys Ile Phe
    130                 135                 140                 
Gln Asp Gln Lys Gly Glu Phe Ala Cys Ser Ala Asp Gln Thr Glu Gly
145                 150                 155                 160 
Glu Ile Lys Gly Ile Leu Asn Leu Leu Arg Ala Ser Leu Ile Ala Phe
                165                 170                 175     
Pro Gly Glu Arg Ile Leu Gln Glu Ala Glu Ile Phe Ala Thr Thr Tyr
            180                 185                 190         
Leu Lys Glu Ala Leu Pro Lys Ile Gln Gly Ser Arg Leu Ser Gln Glu
        195                 200                 205             
Ile Glu Tyr Val Leu Glu Tyr Gly Trp Leu Thr Asp Leu Pro Arg Leu
    210                 215                 220                 
Glu Thr Arg Asn Tyr Ile Glu Val Leu Ala Glu Glu Ile Thr Pro Tyr
225                 230                 235                 240 
Phe Lys Lys Pro Cys Met Ala Val Glu Lys Leu Leu Lys Leu Ala Lys
                245                 250                 255     
Ile Glu Phe Asn Leu Phe His Ser Leu Gln Gln Thr Glu Leu Lys His
            260                 265                 270         
Leu Ser Arg Trp Trp Lys Asp Ser Gly Phe Ala Gln Leu Thr Phe Thr
        275                 280                 285             
Arg His Arg His Val Glu Phe Tyr Thr Leu Ala Ser Cys Ile Ala Met
    290                 295                 300                 
Glu Pro Lys His Ser Ala Phe Arg Leu Gly Phe Ala Lys Leu Cys Tyr
305                 310                 315                 320 
Leu Gly Ile Val Leu Asp Asp Ile Tyr Asp Thr Tyr Gly Lys Met Glu
                325                 330                 335     
Glu Leu Glu Leu Phe Thr Ala Ala Ile Lys Arg Trp Asp Thr Ser Thr
            340                 345                 350         
Thr Glu Cys Leu Pro Glu Tyr Met Lys Gly Val Tyr Met Ala Phe Tyr
        355                 360                 365             
Asp Cys Val Asn Glu Met Ala Arg Gln Ala Glu Lys Thr Gln Gly Trp
    370                 375                 380                 
Asp Thr Leu Asp Tyr Ala Arg Lys Thr Trp Glu Ala Leu Ile Asp Ala
385                 390                 395                 400 
Phe Met Glu Glu Ala Lys Trp Ile Ser Ser Gly Tyr Val Pro Thr Phe
                405                 410                 415     
Gln Lys Tyr Leu Asp Asn Gly Lys Val Ser Phe Gly Tyr Arg Ala Ala
            420                 425                 430         
Thr Leu Gln Pro Ile Leu Thr Leu Asp Ile Pro Leu Pro Leu His Ile
        435                 440                 445             
Leu Gln Glu Ile Asp Phe Pro Ser Ser Phe Asn Asp Leu Ala Ser Ser
    450                 455                 460                 
Ile Leu Arg Leu Arg Gly Asp Ile Cys Gly Tyr Gln Ala Glu Arg Ser
465                 470                 475                 480 
Arg Gly Glu Gln Ala Ser Ser Ile Ser Cys Tyr Met Lys Asp Asn Pro
                485                 490                 495     
Gly Ser Thr Glu Glu Asp Ala Leu Ser His Val Asn Ala Met Ile Gly
            500                 505                 510         
Asp Lys Ile Pro Glu Phe Asn Trp Glu Phe Met Lys Pro Ser Lys Ala
        515                 520                 525             
Pro Ile Ser Ser Lys Lys Tyr Ala Phe Asp Ile Leu Arg Ala Phe Tyr
    530                 535                 540                 
His Leu Tyr Lys Tyr Arg Asp Gly Phe Ser Ile Ala Lys Ile Glu Thr
545                 550                 555                 560 
Lys Lys Leu Val Met Arg Thr Val Leu Asp Pro Val Pro Met
                565                 570                 


<210> 465
<211> 801
<212> PRT
<213> Pisum sativum

<220> 
<223> ent-kaurene synthase A Acc. No. AAB58822

<400> 465
Met Phe Thr His Phe Ser Thr His Phe His Leu Pro Ser Ser Ser Ser
 1               5                  10                  15      
Leu Phe Phe Leu His Pro Phe Tyr Lys Ser Ser Ser Leu Gly Ala Val
            20                  25                  30          
Ser Phe Val Ala Lys Asp Lys Glu Lys Arg Cys Arg Ala Ile Ser Lys
        35                  40                  45              
Ser Arg Thr Gln Glu Tyr Glu Gly Val Phe Gln Thr Asn Val Ala Thr
    50                  55                  60                  
Leu Lys Leu Ser Glu Ile Asn Val Glu Asp Val Ile Val Ile Asp Asp
65                  70                  75                  80  
Glu Glu Glu Gln Asp Ile Arg Val Gly Leu Val Asn Lys Ile Lys Ser
                85                  90                  95      
Ile Leu Ser Ser Leu Glu Asp Gly Glu Ile Thr Ile Ser Ala Tyr Asp
            100                 105                 110         
Thr Ala Trp Val Ala Leu Val Glu Asp Val Asn Ala Ile Ser Thr Pro
        115                 120                 125             
Gln Phe Pro Ser Ser Leu Glu Trp Ile Ala Lys Asn Gln Leu Gln Asp
    130                 135                 140                 
Gly Ser Trp Gly Asp Ser Arg Leu Phe Ser Ala His Asp Arg Ile Ile
145                 150                 155                 160 
Asn Thr Leu Ala Cys Val Ile Ala Leu Arg Ser Trp Asn Met His Ser
                165                 170                 175     
Glu Lys Cys Asp Lys Gly Met Ile Phe Phe Arg Glu Asn Leu Ser Lys
            180                 185                 190         
Leu Glu Asn Glu Asn Glu Glu His Met Pro Ile Gly Phe Glu Val Ala
        195                 200                 205             
Phe Pro Ser Leu Leu Glu Gly Ala Arg Gly Ile Lys Pro Leu Met Cys
    210                 215                 220                 
Pro Asn Asp Ser Pro Ile Leu Lys Asn Ile Phe Glu Lys Arg Asp Glu
225                 230                 235                 240 
Lys Leu Thr Arg Ile Pro Lys Glu Ile Met His Lys Val Pro Thr Thr
                245                 250                 255     
Leu Leu His Ser Leu Glu Gly Met Ser Gly Leu Asp Trp Lys Gln Leu
            260                 265                 270         
Leu Lys Leu Gln Ser Gln Asp Gly Ser Phe Leu Phe Ser Pro Ser Ser
        275                 280                 285             
Thr Ala Phe Ala Leu Met Gln Thr Lys Asp Gly Asn Cys Leu Lys Tyr
    290                 295                 300                 
Leu Asn Asn Val Val Lys Lys Phe Asn Gly Gly Val Pro Asn Val Tyr
305                 310                 315                 320 
Pro Val Asp Leu Phe Glu His Ile Trp Val Val Asp Arg Leu Glu Arg
                325                 330                 335     
Leu Gly Ile Ser Arg Phe Phe Arg His Glu Ile Lys Asp Cys Met Asn
            340                 345                 350         
Tyr Val Ser Lys Ile Trp Ser Glu Lys Gly Ile Cys Trp Ala Arg Asn
        355                 360                 365             
Ser Asn Val Gln Asp Ile Asp Asp Thr Ala Met Ala Phe Arg Leu Leu
    370                 375                 380                 
Arg Leu His Gly His Gln Val Ser Ala His Val Phe Lys His Phe Glu
385                 390                 395                 400 
Arg Asn Gly Glu Phe Phe Cys Phe Ala Gly Gln Cys Thr Gln Ala Val
                405                 410                 415     
Thr Gly Met Tyr Asn Leu Phe Arg Ala Ser Gln Val Leu Phe Pro Gly
            420                 425                 430         
Glu Lys Ile Leu Glu His Ala Lys His Phe Ser Ala Lys Val Leu Lys
        435                 440                 445             
Glu Lys Arg Glu Ala Asn Glu Leu Ile Asp Lys Trp Ile Ile Met Lys
    450                 455                 460                 
Asn Leu Pro Glu Glu Val Gly Tyr Ala Leu Asp Met Pro Trp Tyr Ala
465                 470                 475                 480 
Asn Leu Asp Arg Ile Glu Thr Arg Phe Tyr Ile Asp Gln Tyr Gly Ala
                485                 490                 495     
Glu Ser Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met Ala Tyr Val
            500                 505                 510         
Asn Asn Asn Asn Tyr Leu Glu Leu Ala Lys Leu Asp Tyr Asn Asn Cys
        515                 520                 525             
Gln Ala Gln His Leu Ile Glu Trp Asn Val Ile Gln Thr Trp Tyr Leu
    530                 535                 540                 
Glu Ser Arg Leu Gly Glu Phe Gly Leu Ser Lys Arg Asp Leu Leu Leu
545                 550                 555                 560 
Ala Tyr Phe Leu Ala Thr Gly Ser Ile Phe Glu Pro Glu Arg Ser His
                565                 570                 575     
Glu Arg Leu Ala Trp Ala Lys Thr Thr Ala Leu Leu Glu Thr Ile Lys
            580                 585                 590         
Cys Tyr Val Arg Asn Glu Asp Leu Arg Lys Asp Phe Ala Lys Lys Phe
        595                 600                 605             
Asn Asp His Ile Asp Val Arg Asp Tyr Ser Ile Ala Arg Arg Met Lys
    610                 615                 620                 
Arg Asn Lys Thr Glu His Glu Leu Val Glu Ser Leu Phe Ala Thr Ile
625                 630                 635                 640 
Gly Glu Ile Ser Trp Asp Val Arg Leu Ser Tyr Gly His Glu Ile Gly
                645                 650                 655     
Tyr Asp Met His Gln Cys Trp Lys Lys Trp Leu Ser Ser Trp Gln Ser
            660                 665                 670         
Glu Gly Asp Lys Cys Glu Gly Glu Ala Glu Leu Leu Ile Gln Ile Ile
        675                 680                 685             
Asn Leu Cys Ser Asn His Trp Ile Ser Glu Gly Pro Ser Met Gln Ser
    690                 695                 700                 
Thr Ile Gln His Leu Leu Gln Leu Thr Asn Ser Ile Cys His Lys Leu
705                 710                 715                 720 
Ser Cys Tyr Gln Lys Asp Lys Glu Leu Lys Gly Ile Ser Cys Gln Glu
                725                 730                 735     
Asn Ile Thr Asn Ser Glu Val Glu Ser Lys Met Gln Glu Leu Val Gln
            740                 745                 750         
Met Val Phe Gln Lys Cys Pro Asn Asp Ile Asp Phe Asn Val Lys Asn
        755                 760                 765             
Thr Phe Phe Thr Ile Ala Lys Ser Phe Tyr Tyr Ala Ala Phe Cys Asp
    770                 775                 780                 
Ser Arg Thr Ile Asn Phe His Ile Ala Lys Val Leu Phe Glu Lys Val
785                 790                 795                 800 
Val
    


<210> 466
<211> 545
<212> PRT
<213> Pogostemon cablin

<220> 
<223> (-)-germacrene D synthase Acc. No. AAS86322

<400> 466
Met Asp Leu Asn Glu Ile Thr Ser Ser Ser Arg Pro Leu Ala Asn Tyr
 1               5                  10                  15      
His Pro Asn Val Trp Gly Asp Arg Phe Leu Leu His Glu Pro Glu Phe
            20                  25                  30          
Thr Cys Gln Ala Gly Glu Lys Gln Leu Val Glu Glu Leu Lys Glu Glu
        35                  40                  45              
Val Arg Arg Glu Leu Lys Glu Ala Ser Asn Asp Tyr Leu Arg Gln Leu
    50                  55                  60                  
Lys Met Val Asp Ala Ile Gln Arg Leu Gly Ile Glu Tyr Leu Phe Glu
65                  70                  75                  80  
Glu Glu Ile Asp Glu Ala Leu Arg Asn Leu Leu Ala Lys Phe Glu Asn
                85                  90                  95      
Tyr Cys Lys Asp Asn His Asp Met Tyr Ala Thr Ala Leu Ser Phe Arg
            100                 105                 110         
Leu Leu Arg Gln His Gly Tyr Lys Val Ser Cys Glu Val Phe Asp Lys
        115                 120                 125             
Phe Lys Asp Gly Glu Asp Gly Phe Lys Val Glu Glu Val Met Ala Val
    130                 135                 140                 
Leu Glu Leu Phe Glu Ala Thr His Met Arg Ile His Gly Glu Asp Val
145                 150                 155                 160 
Leu Asp Gln Ala Phe Val Phe Thr Arg Asn Tyr Leu Gln Ser Ile His
                165                 170                 175     
Ala Thr Leu Ser Asn Pro Ile Ala Lys Gln Val His Asn Ala Leu Asn
            180                 185                 190         
Gly Tyr Ser Cys Arg Arg Gly Met Pro Arg Ile Glu Ala Arg Lys Tyr
        195                 200                 205             
Ile Pro Ile Tyr Glu Glu Tyr Gly Cys His His Lys Ala Leu Leu Lys
    210                 215                 220                 
Leu Ala Lys Leu Asp Phe Asn Leu Leu Gln Ser Met His Lys Arg Glu
225                 230                 235                 240 
Leu Thr Gln Leu Tyr Arg Trp Trp Lys Asp Leu Glu Met Pro Thr Lys
                245                 250                 255     
Leu Pro Tyr Ile Arg Asp Arg Leu Val Glu Thr Tyr Phe Trp Asp Met
            260                 265                 270         
Gly Phe Tyr Phe Glu Pro Gln Tyr Ala Leu Ala Arg Asn Ile Leu Val
        275                 280                 285             
Lys Val Gln Cys Leu Val Ser Ile Phe Asp Asp Thr Phe Asp Ala Tyr
    290                 295                 300                 
Gly Ala Phe Lys Glu Leu Gln Leu Phe Lys Asp Ala Ile Asp Arg Trp
305                 310                 315                 320 
Ser Ile Ser Cys Leu Asp Glu Leu Pro Glu Tyr Met Gln Ile Ile Tyr
                325                 330                 335     
Lys Leu Val Leu Asp Val Phe Glu Glu Ile Glu Ser His Met Ile Lys
            340                 345                 350         
Gln Gly Thr Ser Tyr Arg Leu Asp Tyr Ala Arg Glu Ala Ile Lys Ile
        355                 360                 365             
Val Ile Gly Gly Tyr Phe Asp Glu Ala Lys Trp Arg Glu Glu Glu Tyr
    370                 375                 380                 
Lys Pro Arg Met Glu Glu Tyr Met Lys Val Ala Thr Lys Ser Ala Ala
385                 390                 395                 400 
Tyr Leu Thr Leu Ile Ile Val Ser Phe Val Gly Met Lys Asn Asp Ile
                405                 410                 415     
Ala Thr Pro Gln Ala Phe Gln Trp Val Leu Ser Glu Pro Gln Ile Ile
            420                 425                 430         
Thr Ala Ser Leu Ala Leu Ala Arg Leu Ser Asn Asp Leu Val Gly Ile
        435                 440                 445             
Glu Phe Glu Lys Glu Arg Lys Tyr Ile Ala Thr Ala Val Glu Leu Tyr
    450                 455                 460                 
Glu Glu Glu His Lys Val Ser Lys Glu Glu Ala Val Leu Glu Leu Arg
465                 470                 475                 480 
His Glu Thr Glu Ser Ala Trp Lys Glu Ile Asn Glu Ala Leu Leu Glu
                485                 490                 495     
Pro Thr Thr Phe Ala Thr Pro Ile Leu Asp Arg Ile Leu Asn Ser Ala
            500                 505                 510         
Arg Val Leu Glu Val Phe Tyr Asp Lys Thr Asp Arg Tyr Thr His Val
        515                 520                 525             
Asp Leu Glu Leu Gln Asn Ile Ile Ala Gln Leu Tyr Ile His Pro Ile
    530                 535                 540                 
Pro
545 


<210> 467
<211> 554
<212> PRT
<213> Pogostemon cablin

<220> 
<223> (-)-germacrene A synthase Acc. No. AAS86320

<400> 467
Met Glu Leu Lys Asn Gln Ser Val Ala Ile Ile Ser Ser Asn Ala Ser
 1               5                  10                  15      
Arg Pro Leu Ala His Tyr His Pro Asp Val Trp Gly Asp Arg Phe Leu
            20                  25                  30          
Leu Tyr Lys Pro Asn Pro Ser Ser Glu Ala Gly Gln Lys Pro Val Ile
        35                  40                  45              
Glu Glu Leu Lys Gln Gln Val Arg Ser Glu Leu Lys Glu Ala Ser Asn
    50                  55                  60                  
Asp Tyr Met Arg Gln Leu Lys Met Val Asp Ala Ile Gln Arg Leu Gly
65                  70                  75                  80  
Ile Glu Ser Leu Phe Glu Glu Asp Ile Asp Asn Ala Leu Lys Asn Leu
                85                  90                  95      
Ser Glu Asn Phe Asp Asp Tyr Cys Lys Asp Lys His Asp Leu Tyr Ala
            100                 105                 110         
Ile Ala Leu Ser Phe Arg Leu Leu Arg Gln His Gly Tyr Arg Ile Ser
        115                 120                 125             
Cys Asp Val Phe Asp Lys Leu Lys Asp Gly Glu Asp Gly Phe Lys Val
    130                 135                 140                 
Pro Pro Ser Asp Glu Ala Leu Ala Val Val Glu Leu Leu Glu Ala Thr
145                 150                 155                 160 
His Leu Arg Ile His Gly Glu Val Val Leu Asp Arg Ala Phe Val Phe
                165                 170                 175     
Ala Arg Ile His Leu Glu Ser Ile Glu Ala Asn Leu Asn Asn Pro Val
            180                 185                 190         
Ala Lys Gln Val His Asn Ala Leu Tyr Gly Tyr Ser Asn Arg Arg Gly
        195                 200                 205             
Met Gln Gln Val Glu Ala Arg Lys Tyr Ile Pro Ile Tyr Glu Gln Tyr
    210                 215                 220                 
Ala Ser His His Gln Gly Leu Leu Lys Leu Ala Thr Leu Asn Phe Asn
225                 230                 235                 240 
Leu Gln Gln Thr Met His Lys Arg Glu Leu Ser Glu Leu Ser Arg Trp
                245                 250                 255     
Tyr Arg Asp Leu Glu Val Pro Thr Met Leu Pro Phe Ala Arg Gln Arg
            260                 265                 270         
Leu Val Glu Thr Tyr Phe Trp Asp Ala Gly Val Val Phe Glu Pro Glu
        275                 280                 285             
Asn Asp Val Ala Arg Met Ile Leu Val Lys Val Gln Cys Leu Ile Ser
    290                 295                 300                 
Phe Leu Asp Asp Thr Phe Asp Ala Tyr Gly Ser Phe Glu Glu Leu Gln
305                 310                 315                 320 
Leu Phe Thr Asp Ala Ile Asn Thr Trp Asp Val Ser Cys Leu Asp Gln
                325                 330                 335     
Leu Pro Asp Tyr Met Lys Ile Ile Tyr Lys Ala Leu Leu Gly Val Phe
            340                 345                 350         
Glu Val Ile Glu Lys Leu Met Ile Lys Gln Gly Thr Leu Tyr Arg Leu
        355                 360                 365             
Asn Tyr Ala Lys Glu Ala Met Lys Ile Val Val Gly Gly Tyr Phe Val
    370                 375                 380                 
Glu Ala Lys Trp Arg Glu Glu Lys Ser Lys Pro Thr Thr Gln Glu Tyr
385                 390                 395                 400 
Met Gln Val Ala Thr Lys Ser Ala Gly Tyr Met Thr Leu Ile Ile Thr
                405                 410                 415     
Ser Phe Leu Gly Met Glu Ala Asn Ile Ala Thr Lys Glu Ala Phe Asp
            420                 425                 430         
Trp Val Leu Ser Glu Pro Asp Val Met Lys Ala Ala Ile Thr Leu Ala
        435                 440                 445             
Arg Leu Thr Asn Asp Ile Val Gly Ile Glu Leu Glu Lys Glu Arg Lys
    450                 455                 460                 
His Ile Ala Thr Ala Val Glu Val Tyr Glu Asp Glu His Lys Leu Ser
465                 470                 475                 480 
Met Gln Glu Ala Met Val Glu Ile Lys Asn Gln Ile Glu Ser Gly Trp
                485                 490                 495     
Lys Thr Ile Asn Glu Ala Phe Leu Arg Pro Thr Lys Phe Pro Thr Pro
            500                 505                 510         
Ile Leu Tyr Arg Ile Leu Asn Tyr Cys Arg Val Leu Glu Val Ile Tyr
        515                 520                 525             
Asp Lys Ser Asp Arg Tyr Thr His Val Asp Pro Ala Leu Gln Asp Ile
    530                 535                 540                 
Ile Lys Gln Leu Tyr Ile His Pro Ile Pro
545                 550                 


<210> 468
<211> 554
<212> PRT
<213> Pogostemon cablin

<220> 
<223> (-)-germacrene A synthase Acc. No. AAS86321

<400> 468
Met Ala Val Gln Ile Ser Glu Thr Val Arg Pro Phe Ala Asn Phe Ser
 1               5                  10                  15      
Pro Asn Pro Ser Leu Trp Gly Asp Gln Phe Ile Asn His Lys Ser Lys
            20                  25                  30          
Thr Gln Gln Ile Ser Arg Ile Tyr Leu Glu Glu Ile Glu Gly Leu Lys
        35                  40                  45              
Asn Glu Val Lys Cys Met Leu Thr Ser Thr Pro Glu Gly Lys Met Ala
    50                  55                  60                  
Asp Thr Val Asn Leu Ile Asp Thr Leu Glu Arg Leu Gly Val Ser Tyr
65                  70                  75                  80  
His Phe Glu Lys Glu Ile Glu Glu Lys Met Lys His Leu Phe Asn Leu
                85                  90                  95      
Ile Lys Ala Asp Asn Tyr Lys Asp His Glu Gly Cys Asp Leu Tyr Thr
            100                 105                 110         
Asp Ala Leu His Phe Arg Leu Phe Arg Gln His Gly Tyr Pro Ile Ser
        115                 120                 125             
Ser Gly Ile Phe Asn Lys Trp Met Asp Gly Asn Gly Lys Phe Lys Glu
    130                 135                 140                 
Ser Ile Lys Ser Asp Ala Lys Gly Leu Leu Ser Leu Tyr Glu Ala Cys
145                 150                 155                 160 
Cys Leu Arg Thr His Gly Asp Thr Leu Leu Asp Glu Ala Leu Val Phe
                165                 170                 175     
Ala Thr Ala Ser Leu Lys Ser Met Ala Ala Asn Leu Ala Ser Pro Leu
            180                 185                 190         
Arg Lys Gln Val Glu His Ala Leu Phe Gln His Leu His Phe Gly Ile
        195                 200                 205             
Pro Arg Val Glu Ala Arg His Phe Ile Thr Phe Tyr Glu Glu Glu Glu
    210                 215                 220                 
His Lys Asn Glu Met Leu Leu Arg Phe Ala Lys Leu Asp Phe Asn Ala
225                 230                 235                 240 
Leu Gln Ala Leu His Lys Glu Glu Leu Ser Glu Ile Ser Lys Trp Trp
                245                 250                 255     
Lys Asp Leu Asp Leu Ile Ser Lys Leu Pro Tyr Ala Arg Asp Arg Val
            260                 265                 270         
Val Glu Ser Tyr Phe Trp Ala Val Gly Val Tyr Tyr Gln Pro Lys Tyr
        275                 280                 285             
Ser Arg Ala Arg Ile Met Leu Thr Lys Thr Ile Ala Met Thr Ala Ile
    290                 295                 300                 
Leu Asp Asp Thr Tyr Asp Ser Tyr Gly Thr Leu Glu Glu Leu Asp Val
305                 310                 315                 320 
Leu Thr Lys Ala Ile Glu Arg Trp Asp Ile Lys Glu Ile Asn Gly Leu
                325                 330                 335     
Pro Glu Tyr Ile Lys Gly Phe Tyr Lys Gln Val Leu Lys Leu Tyr Gln
            340                 345                 350         
Gln Leu Glu Glu Glu Leu Ala Lys Glu Gly Arg Ser Tyr Ala Val Tyr
        355                 360                 365             
Tyr Ala Ile Glu Ala Cys Lys Glu Leu Ala Arg Ser Tyr Ala Val Glu
    370                 375                 380                 
Ala Lys Trp Phe Lys Lys Gly Tyr Leu Pro Gly Phe Glu Glu Tyr Leu
385                 390                 395                 400 
Ile Asn Ser Leu Val Thr Ser Thr Ala Gly Tyr Leu Asn Ile Ile Ser
                405                 410                 415     
Phe Phe Gly Val Glu Ser Val Thr Lys Glu Asp Phe Glu Trp Phe Ser
            420                 425                 430         
Lys Lys Pro Arg Ile Ala Val Ala Thr Gln Ile Ile Thr Arg Val Ile
        435                 440                 445             
Asp Asp Ile Ala Thr Tyr Glu Val Glu Lys Glu Lys Gly Gln Ser Ala
    450                 455                 460                 
Thr Gly Ile Asp Cys Tyr Met Lys Glu His Gly Val Ser Lys Glu Lys
465                 470                 475                 480 
Ala Met Gln Arg Phe Tyr Glu Met Ser Thr Asn Ala Trp Lys Asp Ile
                485                 490                 495     
Asn Glu Glu Gly Leu Ser Trp Pro Ser Ser Phe Ser Arg Asp Ile Phe
            500                 505                 510         
Val Gln Leu Arg Asn Phe Ser Arg Met Val Asp Val Thr Tyr Gly Lys
        515                 520                 525             
Asn Glu Asp Gly Tyr Ser Lys Pro Glu Lys Ile Leu Lys Pro Leu Ile
    530                 535                 540                 
Ile Ala Leu Phe Val Asp Gln Ile Lys Leu
545                 550                 


<210> 469
<211> 552
<212> PRT
<213> Pogostemon cablin

<220> 
<223> patchoulol synthase Acc. No. AAS86323

<400> 469
Met Glu Leu Tyr Ala Gln Ser Val Gly Val Gly Ala Ala Ser Arg Pro
 1               5                  10                  15      
Leu Ala Asn Phe His Pro Cys Val Trp Gly Asp Lys Phe Ile Val Tyr
            20                  25                  30          
Asn Pro Gln Ser Cys Gln Ala Gly Glu Arg Glu Glu Ala Glu Glu Leu
        35                  40                  45              
Lys Val Glu Leu Lys Arg Glu Leu Lys Glu Ala Ser Asp Asn Tyr Met
    50                  55                  60                  
Arg Gln Leu Lys Met Val Asp Ala Ile Gln Arg Leu Gly Ile Asp Tyr
65                  70                  75                  80  
Leu Phe Val Glu Asp Val Asp Glu Ala Leu Lys Asn Leu Phe Glu Met
                85                  90                  95      
Phe Asp Ala Phe Cys Lys Asn Asn His Asp Met His Ala Thr Ala Leu
            100                 105                 110         
Ser Phe Arg Leu Leu Arg Gln His Gly Tyr Arg Val Ser Cys Glu Val
        115                 120                 125             
Phe Glu Lys Phe Lys Asp Gly Lys Asp Gly Phe Lys Val Pro Asn Glu
    130                 135                 140                 
Asp Gly Ala Val Ala Val Leu Glu Phe Phe Glu Ala Thr His Leu Arg
145                 150                 155                 160 
Val His Gly Glu Asp Val Leu Asp Asn Ala Phe Asp Phe Thr Arg Asn
                165                 170                 175     
Tyr Leu Glu Ser Val Tyr Ala Thr Leu Asn Asp Pro Thr Ala Lys Gln
            180                 185                 190         
Val His Asn Ala Leu Asn Glu Phe Ser Phe Arg Arg Gly Leu Pro Arg
        195                 200                 205             
Val Glu Ala Arg Lys Tyr Ile Ser Ile Tyr Glu Gln Tyr Ala Ser His
    210                 215                 220                 
His Lys Gly Leu Leu Lys Leu Ala Lys Leu Asp Phe Asn Leu Val Gln
225                 230                 235                 240 
Ala Leu His Arg Arg Glu Leu Ser Glu Asp Ser Arg Trp Trp Lys Thr
                245                 250                 255     
Leu Gln Val Pro Thr Lys Leu Ser Phe Val Arg Asp Arg Leu Val Glu
            260                 265                 270         
Ser Tyr Phe Trp Ala Ser Gly Ser Tyr Phe Glu Pro Asn Tyr Ser Val
        275                 280                 285             
Ala Arg Met Ile Leu Ala Lys Gly Leu Ala Val Leu Ser Leu Met Asp
    290                 295                 300                 
Asp Val Tyr Asp Ala Tyr Gly Thr Phe Glu Glu Leu Gln Met Phe Thr
305                 310                 315                 320 
Asp Ala Ile Glu Arg Trp Asp Ala Ser Cys Leu Asp Lys Leu Pro Asp
                325                 330                 335     
Tyr Met Lys Ile Val Tyr Lys Ala Leu Leu Asp Val Phe Glu Glu Val
            340                 345                 350         
Asp Glu Glu Leu Ile Lys Leu Gly Ala Pro Tyr Arg Ala Tyr Tyr Gly
        355                 360                 365             
Lys Glu Ala Met Lys Tyr Ala Ala Arg Ala Tyr Met Glu Glu Ala Gln
    370                 375                 380                 
Trp Arg Glu Gln Lys His Lys Pro Thr Thr Lys Glu Tyr Met Lys Leu
385                 390                 395                 400 
Ala Thr Lys Thr Cys Gly Tyr Ile Thr Leu Ile Ile Leu Ser Cys Leu
                405                 410                 415     
Gly Val Glu Glu Gly Ile Val Thr Lys Glu Ala Phe Asp Trp Val Phe
            420                 425                 430         
Ser Arg Pro Pro Phe Ile Glu Ala Thr Leu Ile Ile Ala Arg Leu Val
        435                 440                 445             
Asn Asp Ile Thr Gly His Glu Phe Glu Lys Lys Arg Glu His Val Arg
    450                 455                 460                 
Thr Ala Val Glu Cys Tyr Met Glu Glu His Lys Val Gly Lys Gln Glu
465                 470                 475                 480 
Val Val Ser Glu Phe Tyr Asn Gln Met Glu Ser Ala Trp Lys Asp Ile
                485                 490                 495     
Asn Glu Gly Phe Leu Arg Pro Val Glu Phe Pro Ile Pro Leu Leu Tyr
            500                 505                 510         
Leu Ile Leu Asn Ser Val Arg Thr Leu Glu Val Ile Tyr Lys Glu Gly
        515                 520                 525             
Asp Ser Tyr Thr His Val Gly Pro Ala Met Gln Asn Ile Ile Lys Gln
    530                 535                 540                 
Leu Tyr Leu His Pro Val Pro Tyr
545                 550         


<210> 470
<211> 545
<212> PRT
<213> Pogostemon cablin

<220> 
<223> gamma-curcumene synthase Acc. No. AAS86319

<400> 470
Met Ala Ala Phe Thr Ala Asn Ala Val Asp Met Arg Pro Pro Val Ile
 1               5                  10                  15      
Thr Ile His Pro Arg Ser Lys Asp Ile Phe Ser Gln Phe Ser Leu Asp
            20                  25                  30          
Asp Lys Leu Gln Lys Gln Tyr Ala Gln Gly Ile Glu Ala Leu Lys Glu
        35                  40                  45              
Glu Ala Arg Ser Met Leu Met Ala Ala Lys Ser Ala Lys Val Met Ile
    50                  55                  60                  
Leu Ile Asp Thr Leu Glu Arg Leu Gly Leu Gly Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Glu Lys Leu Glu Ala Ile Tyr Lys Lys Glu Asp Gly Asp
                85                  90                  95      
Asp Tyr Asp Leu Phe Thr Thr Ala Leu Arg Phe Arg Leu Leu Arg Gln
            100                 105                 110         
His Gln Arg Arg Val Pro Cys Ser Val Phe Asp Lys Phe Met Asn Lys
        115                 120                 125             
Glu Gly Lys Phe Glu Glu Glu Pro Leu Ile Ser Asp Val Glu Gly Leu
    130                 135                 140                 
Leu Ser Leu Tyr Asp Ala Ala Tyr Leu Gln Ile His Gly Glu His Ile
145                 150                 155                 160 
Leu Gln Glu Ala Leu Ile Phe Thr Thr His His Leu Thr Arg Ile Glu
                165                 170                 175     
Pro Gln Leu Asp Asp His Ser Pro Leu Lys Leu Lys Leu Asn Arg Ala
            180                 185                 190         
Leu Glu Phe Pro Phe Tyr Arg Glu Ile Pro Ile Ile Tyr Ala His Phe
        195                 200                 205             
Tyr Ile Ser Val Tyr Glu Arg Asp Asp Ser Arg Asp Glu Val Leu Leu
    210                 215                 220                 
Lys Met Ala Lys Leu Ser Tyr Asn Phe Leu Gln Asn Leu Tyr Lys Lys
225                 230                 235                 240 
Glu Leu Ser Gln Leu Ser Arg Trp Trp Asn Lys Leu Glu Leu Ile Pro
                245                 250                 255     
Asn Leu Pro Tyr Ile Arg Asp Ser Val Ala Gly Ala Tyr Leu Trp Ala
            260                 265                 270         
Val Ala Leu Tyr Phe Glu Pro Gln Tyr Ser Asp Val Arg Met Ala Ile
        275                 280                 285             
Ala Lys Leu Ile Gln Ile Ala Ala Ala Val Asp Asp Thr Tyr Asp Asn
    290                 295                 300                 
Tyr Ala Thr Ile Arg Glu Ala Gln Leu Leu Thr Glu Ala Leu Glu Arg
305                 310                 315                 320 
Leu Asn Val His Glu Ile Asp Thr Leu Pro Asp Tyr Met Lys Ile Val
                325                 330                 335     
Tyr Arg Phe Val Met Ser Trp Ser Glu Asp Phe Glu Arg Asp Ala Thr
            340                 345                 350         
Ile Lys Glu Gln Met Leu Ala Thr Pro Tyr Phe Lys Ala Glu Met Lys
        355                 360                 365             
Lys Leu Gly Arg Ala Tyr Asn Gln Glu Leu Lys Trp Val Met Glu Arg
    370                 375                 380                 
Gln Leu Pro Ser Phe Glu Glu Tyr Met Lys Asn Ser Glu Ile Thr Ser
385                 390                 395                 400 
Gly Val Tyr Ile Met Phe Thr Val Ile Ser Pro Tyr Leu Asn Ser Ala
                405                 410                 415     
Thr Gln Lys Asn Ile Asp Trp Leu Leu Ser Gln Pro Arg Leu Ala Ser
            420                 425                 430         
Ser Thr Ala Ile Val Met Arg Cys Cys Asn Asp Leu Gly Ser Asn Gln
        435                 440                 445             
Arg Glu Ser Lys Gly Gly Glu Val Met Thr Ser Leu Asp Cys Tyr Met
    450                 455                 460                 
Lys Gln His Gly Ala Ser Lys Gln Glu Thr Ile Ser Lys Phe Lys Leu
465                 470                 475                 480 
Ile Ile Glu Asp Glu Trp Lys Asn Leu Asn Glu Glu Trp Ala Ala Thr
                485                 490                 495     
Thr Cys Leu Pro Lys Val Met Val Glu Ile Phe Arg Asn Tyr Ala Arg
            500                 505                 510         
Ile Ala Gly Phe Cys Tyr Lys Asn Asn Gly Asp Ala Tyr Thr Ser Pro
        515                 520                 525             
Lys Ile Val Gln Gln Cys Phe Asp Ala Leu Phe Val Asn Pro Leu Arg
    530                 535                 540                 
Ile
545 


<210> 471
<211> 561
<212> PRT
<213> Populus balsamifera

<220> 
<223> ssp. trichocarpa x Populus deltoides
      (-)-germacrene D synthase Acc. No. AAR99061

<400> 471
Met Ser Val Glu Gly Ser Ala Ile Phe Ser Thr Ala Thr Val Glu Pro
 1               5                  10                  15      
Asn Val Ser Arg Arg Ser Ala Gly Tyr Ser Pro Ser Ile Trp Gly Asp
            20                  25                  30          
His Phe Leu Ser Tyr Ala Thr Asp Ser Met Glu Thr Ser Asp Lys Ala
        35                  40                  45              
Glu His Lys Lys Leu Lys Glu Glu Val Lys Arg Glu Leu Met Ala Asn
    50                  55                  60                  
Ile Asn Lys Pro Ser Gln Thr Leu Asp Phe Ile Asp Ala Ile Gln Arg
65                  70                  75                  80  
Leu Gly Ile Ser Tyr His Phe Glu Ile Glu Ile Asp Glu Ile Leu Arg
                85                  90                  95      
Glu Met Tyr Lys Ser His Cys Asp Phe Asp Asn Gly Asp Asp Asp Asp
            100                 105                 110         
His His His Asn Asp Leu Tyr Ala Ile Ser Leu Lys Phe Arg Leu Leu
        115                 120                 125             
Arg Gln Gln Gly Tyr Lys Ile Ser Cys Asp Val Phe Gly Lys Phe Lys
    130                 135                 140                 
Asn Ser Gln Gly Thr Phe Asn Asp Ser Leu Ala Asn Asp Thr Arg Gly
145                 150                 155                 160 
Ile Leu Ser Leu Tyr Glu Ala Thr His Leu Arg Val His Gly Asp Glu
                165                 170                 175     
Val Leu Glu Glu Ala Leu Val Phe Thr Thr Ser His Leu Glu Phe Leu
            180                 185                 190         
Ala Thr His Ser Ser Ser Pro Leu Arg Ala Lys Ile Asn His Ala Leu
        195                 200                 205             
Lys Gln Pro Val Arg Lys Asn Ile Pro Arg Leu Glu Ala Arg His Tyr
    210                 215                 220                 
Phe Ser Ile Tyr Gln Glu Asp Pro Ser Cys Ser Glu Val Leu Leu Asn
225                 230                 235                 240 
Phe Ala Lys Leu Asp Phe Asn Ile Leu Gln Lys Gln His Gln Lys Glu
                245                 250                 255     
Leu Ser Glu Ile Ala Asn Trp Trp Lys Glu Leu Asp Phe Ala Lys Lys
            260                 265                 270         
Leu Pro Phe Ala Arg Asp Arg Val Ile Glu Cys Tyr Phe Trp Ile Leu
        275                 280                 285             
Gly Val Tyr Leu Glu Pro Glu Tyr Phe Leu Ala Arg Arg Ile Leu Thr
    290                 295                 300                 
Lys Val Ile Ala Met Thr Ser Val Ile Asp Asp Ile Tyr Asp Val Tyr
305                 310                 315                 320 
Gly Thr Pro Glu Glu Leu Glu Leu Phe Thr Asp Ala Ile Glu Arg Trp
                325                 330                 335     
Glu Ile Thr Ala Val Asp Gln Leu Pro Glu Tyr Met Lys Val Thr Tyr
            340                 345                 350         
Lys Ala Leu Leu Asp Val Tyr Thr Glu Ile Glu Glu Asn Met Val Thr
        355                 360                 365             
Glu Glu Arg Ser Tyr Arg Val Tyr Tyr Ala Lys Glu Ala Met Lys Asn
    370                 375                 380                 
Leu Val Arg Ala Tyr Tyr Leu Glu Ser Lys Trp Phe His Gln Lys His
385                 390                 395                 400 
Thr Pro Thr Met Glu Glu Tyr Met Ala Val Ala Leu Val Thr Ser Gly
                405                 410                 415     
Tyr Ala Met Leu Ala Ala Thr Ser Phe Val Gly Met Gly His Val Val
            420                 425                 430         
Thr Lys Asp Ser Phe Asp Trp Leu Phe Arg Gly Pro Lys Ile Leu Lys
        435                 440                 445             
Ala Ser Glu Ile Ile Cys Arg Leu Met Asp Asp Ile Val Ser His Lys
    450                 455                 460                 
Phe Glu Gln Lys Arg Gly His Val Ala Ser Ser Ile Glu Cys Tyr Met
465                 470                 475                 480 
Lys Gln His Gly Thr Thr Glu Gln Glu Thr Val His Glu Phe Arg Lys
                485                 490                 495     
Gln Val Thr Asp Ala Trp Lys Asp Leu Asn Glu Glu Phe Leu His Pro
            500                 505                 510         
Thr Ala Val Pro Met Pro Leu Leu Thr Arg Met Leu Asn Leu Ala Arg
        515                 520                 525             
Val Ile Asp Val Val Tyr Lys Asp Glu Asp Gly Tyr Thr Asn Ala Gly
    530                 535                 540                 
Thr Val Leu Lys Asp Leu Val Ser Ala Leu Leu Ile Asp Pro Val Pro
545                 550                 555                 560 
Met
    


<210> 472
<211> 826
<212> PRT
<213> Pseudotsuga menziesii

<220> 
<223> (E)-beta-farnesene synthase Acc. No. AAX07265

<400> 472
Met Ser Leu Glu Glu Phe Tyr Pro Met Ala Thr Val Tyr Val Pro Ser
 1               5                  10                  15      
Ser Thr Leu Pro Cys Ala Leu Ser Thr Ser Ser Ser Ser Ser Ser Leu
            20                  25                  30          
Val Arg Arg Thr Ala Asn Pro His Pro Asn Val Trp Asp Tyr His Phe
        35                  40                  45              
Val Gln Ser Leu Gln Ser Pro Tyr Thr Asp Pro Cys Tyr Gly Glu Arg
    50                  55                  60                  
Val Glu Thr Leu Val Ala Glu Ile Lys Ala Met Leu His Gly Glu Gly
65                  70                  75                  80  
Gly Leu Met Ile Thr Pro Ser Ala Tyr Asp Thr Ala Trp Val Ala Arg
                85                  90                  95      
Val Pro Ser Ile Asp Gly Ser Ala Arg Pro Gln Phe Pro Gln Thr Val
            100                 105                 110         
Gln Trp Ile Leu Lys Asn Gln Leu Lys Asp Gly Ser Trp Gly Thr Glu
        115                 120                 125             
Ser His Phe Leu Leu Ser Asp Arg Leu Leu Ala Thr Leu Ser Cys Val
    130                 135                 140                 
Leu Ala Leu Leu Lys Trp Lys Val Gly Asp Leu Gln Val Gln Gln Gly
145                 150                 155                 160 
Ile Glu Phe Ile Lys Ser Asn Leu Glu Ala Ile Lys Asp Glu Asn Asp
                165                 170                 175     
Glu Asp Ser Leu Val Thr Asp Phe Asp Ile Ile Phe Pro Ser Leu Leu
            180                 185                 190         
Arg Glu Ala Gln Tyr Leu Asp Ile Glu Leu Pro Leu Gln Pro Ala Leu
        195                 200                 205             
Cys Lys Ser Thr Pro Pro Lys Arg Gln Glu Arg Leu Ala Asn Met Ser
    210                 215                 220                 
Arg Glu Glu Ile His Gly Val Pro Ser Pro Leu Leu Tyr Ser Leu Glu
225                 230                 235                 240 
Gly Ile Glu Asp Met Val Asp Trp Glu Arg Ile Met Asp Val Arg Ser
                245                 250                 255     
Gln Asp Gly Ser Phe Leu Ser Ser Pro Ala Ser Ile Ala Cys Val Phe
            260                 265                 270         
Met His Thr Gly Asp Ile Lys Cys Leu Glu Phe Leu Asn Asn Val Leu
        275                 280                 285             
Thr Asn Phe Gly Thr Phe Val Pro Cys Leu Tyr Pro Val Asp Leu Leu
    290                 295                 300                 
Glu Arg Leu Leu Ile Val Asp Asn Leu Val Gln Leu Gly Ile Asp Arg
305                 310                 315                 320 
His Phe Glu Lys Glu Ile Lys Glu Ala Leu Asp Tyr Val His Arg His
                325                 330                 335     
Trp Asn Glu Arg Gly Ile Gly Trp Gly Arg Leu Asn Pro Ile Ala Asp
            340                 345                 350         
Leu Glu Ile Thr Ala Leu Gly Phe Arg Leu Leu Arg Leu His Arg Tyr
        355                 360                 365             
Asn Val Ser Pro Ala Val Phe Glu Asn Phe Lys Asp Ser Asn Gly His
    370                 375                 380                 
Phe Val Cys Ser Gly Ala Gln Phe Asn Lys Asp Val Ala Ser Met Leu
385                 390                 395                 400 
Ser Leu Tyr Arg Ala Ser Gln Leu Ala Phe Pro Gly Glu Asn Ile Leu
                405                 410                 415     
Asp Glu Ala Lys Ser Phe Thr Ser Lys Tyr Leu Lys Glu Ala Leu Glu
            420                 425                 430         
Lys Arg Glu Thr Tyr Ser Ala Trp Asn Asn Lys Gln Ser Leu Ser Glu
        435                 440                 445             
Glu Ile Lys Tyr Ala Leu Glu Asn Ser Trp His Ala Ser Val Pro Arg
    450                 455                 460                 
Val Glu Ala Lys Arg Tyr Cys Gln Val Tyr Arg Ser Asp Tyr Thr Tyr
465                 470                 475                 480 
Leu Ala Lys Ser Val Tyr Lys Leu Pro Lys Val Asn Asn Glu Lys Ile
                485                 490                 495     
Leu Glu Leu Ala Lys Leu Asp Phe Gln His Tyr Pro Gly His Pro Pro
            500                 505                 510         
Lys Arg Asp Glu Glu Cys His His Leu Val Lys Asn Ser Glu Phe Pro
        515                 520                 525             
Leu Leu Pro Phe Gly Arg Glu Arg Pro Val Glu Cys Phe Phe Ile Val
    530                 535                 540                 
Ala Ala Gly Thr Tyr Glu Pro Gln Tyr Ala Lys Cys Arg Phe Leu Phe
545                 550                 555                 560 
Ser Lys Val Ala Cys Leu Asn Thr Val Leu Asp Asp Met Tyr Asp Thr
                565                 570                 575     
Tyr Gly Thr Leu Asp Glu Leu Lys Leu Phe Thr Glu Ala Val Arg Arg
            580                 585                 590         
Trp Asp Leu Ser Leu Thr Glu Asn Leu Pro Asp Tyr Met Lys Leu Cys
        595                 600                 605             
Tyr Lys Ile Phe Tyr Asp Ile Val His Glu Val Val Leu Glu Ala Glu
    610                 615                 620                 
Lys Glu Gln Gly Arg Glu Leu Leu Thr Phe Phe Arg Lys Gly Trp Glu
625                 630                 635                 640 
Glu Tyr Leu Met Gly Tyr Tyr Glu Glu Ala Glu Trp Leu Ala Cys Glu
                645                 650                 655     
Tyr Leu Pro Ser Leu Glu Glu Tyr Ile Arg Asn Gly Ile Ile Ser Ile
            660                 665                 670         
Gly Gln Arg Ile Leu Val Val Ser Gly Val Leu Leu Met Glu Gly Gln
        675                 680                 685             
Ile Leu Ser Gln Glu Ala Leu Glu Gln Leu Asp Tyr Pro Gly Arg Arg
    690                 695                 700                 
Val Leu Thr Glu Leu Asn Ser Ile Ile Thr Arg Leu Ala Asp Asp Ile
705                 710                 715                 720 
His Thr Tyr Lys Ala Glu Lys Ala Arg Gly Glu Leu Ala Ser Ser Ile
                725                 730                 735     
Glu Cys Tyr Met Arg Glu His Pro Gly Ser Thr Glu Glu Val Ala Val
            740                 745                 750         
Asn Tyr Met Tyr Ser Leu Leu Glu Pro Ala Val Lys Glu Leu Thr Trp
        755                 760                 765             
Glu Phe Leu Lys Pro Glu Asp Ser Thr Val His Ile Pro Phe Gln Cys
    770                 775                 780                 
Lys Lys Met Leu Met Glu Glu Thr Arg Val Thr Met Val Ile Phe Lys
785                 790                 795                 800 
Glu Gly Asp Gly Phe Gly Ile Ser Lys Thr Lys Ile Lys Asp Tyr Ile
                805                 810                 815     
Lys Asp Cys Leu Ile Glu Pro Leu Pro Leu
            820                 825     


<210> 473
<211> 815
<212> PRT
<213> Pseudotsuga menziesii

<220> 
<223> (E)-gamma-bisabolene synthase Acc. No. AAX07266

<400> 473
Met Ala Ala Ser Thr Leu Pro Ser Gly Leu Ser Thr Asn Asp Leu Ile
 1               5                  10                  15      
Arg Arg Thr Ala Asn Pro His Pro Asn Val Trp Gly Tyr Asp Leu Leu
            20                  25                  30          
Cys Ser Leu Lys Ser Pro Tyr Ser Arg Asp Ser Ser Tyr Lys Glu Arg
        35                  40                  45              
Ala Asp Thr Leu Ile Asn Glu Ile Lys Ala Met Leu Gly Ala Ala Phe
    50                  55                  60                  
Gly Asp Gly Lys Glu Met Ile Thr Pro Ser Ala Tyr Asp Thr Ala Trp
65                  70                  75                  80  
Val Ala Arg Ile Pro Ser Ile Asp Gly Ser Ser Gly Ser Ala Arg Pro
                85                  90                  95      
Gln Phe Pro Gln Thr Val Asp Trp Ile Leu Lys Asn Gln Leu Lys Asp
            100                 105                 110         
Gly Ser Trp Gly Thr Glu Ser His Phe Leu Leu Ser Glu Pro Leu Leu
        115                 120                 125             
Ala Thr Ile Ser Cys Val Leu Ala Leu Phe Lys Trp Gln Val Gly Asp
    130                 135                 140                 
Leu Gln Val Glu Arg Gly Ile Glu Phe Leu Lys Ser Ser Leu Glu Lys
145                 150                 155                 160 
Ile Lys Asn Glu Ser Asp Gln Asp Ser Leu Val Thr Asp Phe Glu Ile
                165                 170                 175     
Ile Phe Pro Ser Met Leu Arg Glu Ala Gln Ser Leu His Leu Gly Leu
            180                 185                 190         
Pro Tyr Asp Leu Pro Tyr Ile Gln Leu Leu Gln Thr Lys Arg Gln Glu
        195                 200                 205             
Arg Leu Ala Asn Leu Ser Arg Glu Lys Ile His Gly Gly Ile Leu Gln
    210                 215                 220                 
Leu Ser Ser Leu Glu Gly Ile Glu Asp Met Val Glu Trp Glu Arg Leu
225                 230                 235                 240 
Met Asp Leu Gln Ser Leu Asp Gly Ser Phe Leu Ser Ser Pro Ala Ser
                245                 250                 255     
Thr Ala Phe Val Phe Ile His Thr Gly Asp Leu Lys Cys Leu Ala Phe
            260                 265                 270         
Leu Asn Ser Val Leu Ala Lys Phe Gly Ala Phe Val Pro Cys Leu Tyr
        275                 280                 285             
His Val Asp Leu Leu Glu Arg Leu Leu Ile Val Asp Asn Ile Glu Arg
    290                 295                 300                 
Leu Gly Ile Asp Arg His Phe Glu Lys Glu Ile Asn Glu Ala Leu Asp
305                 310                 315                 320 
Tyr Val Tyr Arg Tyr Trp Ser Asn Glu Arg Gly Ile Gly Trp Gly Arg
                325                 330                 335     
Met Asn Ala Thr Ala Asp Leu Glu Thr Thr Ala Leu Gly Phe Arg Leu
            340                 345                 350         
Leu Arg Leu His Arg Tyr His Val Ser Pro Val Val Phe Lys Lys Phe
        355                 360                 365             
Lys Asp Ala Asp Gly Glu Phe Leu Ser Ser Ile Gly Gln Phe Asn Lys
    370                 375                 380                 
Asp Val Ala Ser Met Leu Asn Leu Tyr Arg Ala Cys Glu Leu Ala Phe
385                 390                 395                 400 
Pro Gly Glu Asn Ile Leu Asp Glu Ala Lys Gly Phe Thr Ala Lys Tyr
                405                 410                 415     
Leu Arg Glu Ala Leu Glu Lys Thr Glu Thr Phe Ser Ser Trp Asn Ile
            420                 425                 430         
Lys Arg Asn Leu Ser Gln Glu Ile Lys Tyr Ala Leu Lys Thr Ser Trp
        435                 440                 445             
His Ala Ser Ile Pro Arg Val Glu Ala Lys Arg Tyr Cys Gln Val Tyr
    450                 455                 460                 
Arg Pro Asp Tyr Ala Arg Leu Asp Lys Ser Val Tyr Lys Leu His His
465                 470                 475                 480 
Val Asn Asn Glu Lys Ile Leu Glu Leu Ala Lys Leu Asp Phe Asn Ile
                485                 490                 495     
Ile Gln Ser Ile Leu Gln Glu Glu Met Lys Asn Val Thr Ser Trp Phe
            500                 505                 510         
Arg Asp Ser Gly Leu Pro Leu Phe Ser Phe Ala Arg Gln Arg Pro Leu
        515                 520                 525             
Glu Phe Tyr Phe Leu Ile Thr Ala Gly Thr Tyr Glu Pro Arg Tyr Ala
    530                 535                 540                 
Lys Cys Arg Leu Leu Phe Thr Lys Val Ala Cys Val Glu Thr Val Leu
545                 550                 555                 560 
Asp Asp Met Tyr Asp Thr Tyr Gly Thr Leu Asp Glu Leu Lys Leu Phe
                565                 570                 575     
Thr Gln Ala Val Arg Arg Trp Asp Pro Ser Leu Thr Glu Asn Leu Pro
            580                 585                 590         
Asp Tyr Met Lys Arg Cys Tyr Lys Ile Phe Tyr Asp Ile Val His Glu
        595                 600                 605             
Ala Ala Trp Glu Ala Glu Lys Glu Gln Gly Arg Glu Leu Val Ser Phe
    610                 615                 620                 
Leu Arg Lys Ala Trp Glu Asp Phe Val Leu Ser Tyr His Glu Glu Ala
625                 630                 635                 640 
Glu Trp Leu Ser Ala Glu Tyr Val Pro Gly Phe Asp Glu Tyr Ile Lys
                645                 650                 655     
Asn Gly Ile Thr Ser Ile Gly Gln Arg Val Leu Leu Leu Ser Gly Leu
            660                 665                 670         
Leu Val Met Asp Gly Gln Leu Leu Ser Gln Lys Ala Leu Glu Lys Ile
        675                 680                 685             
Asp Tyr Pro Glu Arg Ser Arg Val Leu Met Glu Gln Ile Cys Leu Ile
    690                 695                 700                 
Ser Arg Leu Ala Asp Asp Thr Gln Ser Tyr Lys Ala Glu Lys Ala Arg
705                 710                 715                 720 
Gly Glu Leu Ala Ser Gly Ile Glu Cys Tyr Met Lys Asp His Pro Glu
                725                 730                 735     
Cys Thr Glu Glu Glu Ala Leu Asn His Ile Tyr Gly Ile Met Glu Val
            740                 745                 750         
Thr Ala Lys Glu Leu Thr Lys Glu Tyr Leu Lys Val Asp Asp Asp Asp
        755                 760                 765             
Val Pro Phe Ala Cys Lys Lys Met Leu Phe Glu Glu Thr Arg Val Thr
    770                 775                 780                 
Met Val Ile Phe Lys Asp Gly Asp Arg Leu Ser Asn Ser Lys Leu Glu
785                 790                 795                 800 
Met Lys Asp His Phe Lys Glu Cys Leu Ile Glu Pro Leu Pro Leu
                805                 810                 815 


<210> 474
<211> 550
<212> PRT
<213> Ricinus communis

<220> 
<223> (+)-delta-cadinene synthase isozyme A Acc. No.
      EEF38721

<400> 474
Met Ser Ala Gln Thr Leu Ala Ile Ser Asn Leu Lys Pro Asn Thr Thr
 1               5                  10                  15      
Arg His Leu Ala Ser Phe His Pro Asn Ile Trp Gly Asp Arg Phe Leu
            20                  25                  30          
Ser Cys Ala Ala Glu Ser Thr Asp Ile Glu Asp Asp Met Glu Gln Gln
        35                  40                  45              
Val Glu Arg Leu Lys Glu Glu Val Lys Lys Met Ile Ala Ser Ala Asp
    50                  55                  60                  
Glu Pro Ser Gln Ile Leu Asn Leu Ile Asp Leu Leu Gln Arg Leu Gly
65                  70                  75                  80  
Val Ser Tyr His Phe Glu Lys Glu Ile Glu Glu Ala Leu Gln Gln Val
                85                  90                  95      
Leu Asn Met Asn Ser Asp Ser Asp Lys Asp Asp Asp Leu His Ser Val
            100                 105                 110         
Ala Leu Arg Phe Arg Leu Leu Arg Glu Gln Gly Leu Asn Val Ser Cys
        115                 120                 125             
Asp Val Phe Asn Lys Phe Arg Asp Arg Asn Gly His Phe Ile Gln Thr
    130                 135                 140                 
Leu Lys Thr Asp Leu Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala His
145                 150                 155                 160 
Phe Arg Val His Gly Glu Gly Ile Leu Asp Asp Ala Leu Ala Phe Thr
                165                 170                 175     
Thr Thr Tyr Leu Glu Ser Ile Val Pro Asn Leu Ser Pro Pro Leu Ala
            180                 185                 190         
Ala Gln Ile Ser Arg Thr Leu Arg Gln Pro Leu Arg Lys Ser Leu Ala
        195                 200                 205             
Arg Val Glu Ala Arg His Phe Ile Ser Ile Tyr Gln Glu Asp Thr Ser
    210                 215                 220                 
His Asn Glu Val Leu Leu Thr Phe Ala Lys Leu Asp Phe Asn Leu Leu
225                 230                 235                 240 
Gln Lys Leu His Gln Lys Glu Leu Lys Tyr Ile Ser Leu Trp Trp Lys
                245                 250                 255     
Asp Leu Asp Phe Val Asn Lys Leu Pro Phe Thr Arg Asp Arg Val Val
            260                 265                 270         
Glu Gly Tyr Phe Trp Ile Leu Gly Val Tyr Phe Glu Pro Gln Tyr His
        275                 280                 285             
Arg Ala Arg Lys Phe Val Thr Lys Val Ile Asn Val Val Ser Val Ile
    290                 295                 300                 
Asp Asp Ile Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Val Val Phe
305                 310                 315                 320 
Thr Asp Ala Ile Asn Arg Trp Asp Ile Asp Cys Ile Asp Gln Leu Pro
                325                 330                 335     
Glu Tyr Met Lys Val Cys Tyr Lys Ala Leu Leu Asn Val Tyr Glu Glu
            340                 345                 350         
Ile Glu Arg Ala Leu Ser Glu Gln Gly Arg Ser Tyr Arg Leu His Tyr
        355                 360                 365             
Ala Lys Glu Ala Met Lys Lys Leu Val Gln Ala Tyr Leu Val Glu Ala
    370                 375                 380                 
Asn Trp Met Asn Lys Asn Tyr Val Pro Thr Met Asp Glu Tyr Met Ser
385                 390                 395                 400 
Ile Ala Leu Val Ser Cys Ala Tyr Pro Leu Leu Thr Val Thr Ser Phe
                405                 410                 415     
Val Gly Met Gly Asp Ile Ala Thr Lys Glu Val Phe Asp Trp Ala Ser
            420                 425                 430         
Asn Asp Pro Lys Ile Val Arg Val Ala Ser Ile Ile Cys Arg Leu Met
        435                 440                 445             
Asp Asp Ile Val Ser His Glu Phe Glu Gln Lys Arg Gly His Ile Ala
    450                 455                 460                 
Ser Ser Val Glu Cys Tyr Met Lys Gln Asn Gly Val Ser Glu Glu Ala
465                 470                 475                 480 
Thr Arg Asp Glu Phe Asn Lys Gln Ile Val Asp Ala Trp Lys Asp Ile
                485                 490                 495     
Asn Glu Glu His Leu Gln Pro Asn Tyr Val Pro Met Pro Phe Arg Thr
            500                 505                 510         
Arg Val Val Asn Ser Ala Arg Ile Met Asp Tyr Leu Tyr Lys Asp Asp
        515                 520                 525             
Asp Glu Tyr Thr His Val Gly Glu Leu Met Lys Gly Ser Val Ala Ala
    530                 535                 540                 
Leu Leu Ile Asp Pro Ala
545                 550 


<210> 475
<211> 394
<212> PRT
<213> Ricinus communis

<220> 
<223> (+)-delta-cadinene synthase isozyme A Acc. No.
      EEF38510

<400> 475
Met Gly Lys Arg Asp Lys Lys Gln Arg His His Asn Gln His Arg Ser
 1               5                  10                  15      
Arg Val Ala Ser Tyr Tyr Asn Thr Glu Gln Glu Asp Asp Gly Tyr Ser
            20                  25                  30          
Tyr Ser Gln Ser Ser Leu Pro Asn Glu Asp Ser Asp Ala Glu Pro Asp
        35                  40                  45              
Asp Val Glu Glu Glu Glu Glu Glu Glu Glu Glu Lys Glu Asp Thr Ser
    50                  55                  60                  
Asp Ala Lys Ala Ser Asn Asp Val Pro Ser Lys Phe Leu Leu Tyr Gln
65                  70                  75                  80  
Gln Ser Val Gln Ser Pro Lys Gly Asp Ile Ser Tyr Leu Gln Lys Phe
                85                  90                  95      
Phe Leu Leu Tyr Val Gly Gly Arg Leu Pro Leu His Phe Gln Glu Asp
            100                 105                 110         
Phe Cys Gly Thr Ala Leu Leu Ser Thr Glu Trp Leu Arg Ser Asp Ser
        115                 120                 125             
Arg Arg Thr Ala Val Gly Val Asp Leu Asp Leu Glu Ala Leu Asn Trp
    130                 135                 140                 
Cys Met Ala Asn Asn Val Asn Lys Ile Gly Ala Asp Gly Tyr Ser Arg
145                 150                 155                 160 
Ile Ser Leu Phe His Gly Asn Val Leu Gln Pro Ser Asp Ala Glu Leu
                165                 170                 175     
Val Arg Phe Glu Pro Gln Asp Leu Ile Ser Asn Ile Lys Leu Gly Glu
            180                 185                 190         
Gln Gly Asp Asn Ser Glu Asn Thr Ala Leu Glu Ser Ala Leu Gln Val
        195                 200                 205             
Gly Ser Ser Ala Ser Val Ser Asp Lys Tyr Leu Lys Arg Asn Phe Gln
    210                 215                 220                 
Leu Pro Ala Arg Asp Ile Val Cys Ala Phe Asn Tyr Ser Cys Cys Cys
225                 230                 235                 240 
Leu His Lys Arg Ala Asp Leu Val Leu Tyr Phe Lys His Val Leu Asp
                245                 250                 255     
Ala Leu Ser Lys Lys Gly Gly Leu Phe Val Met Asp Leu Tyr Gly Gly
            260                 265                 270         
Thr Ser Ser Glu Gly Lys Leu Arg Leu Gln Arg Arg Phe Pro Asn Phe
        275                 280                 285             
Thr Tyr Ile Trp Glu Gln Ala Glu Phe Asn Ile Ile Glu Arg Lys Thr
    290                 295                 300                 
Arg Ile Ser Leu His Phe His Leu Gln Lys Gln Gln Lys Lys Leu Arg
305                 310                 315                 320 
His Ala Phe Ser Tyr Ser Trp Arg Leu Trp Ser Leu Pro Glu Ile Arg
                325                 330                 335     
Asp Cys Leu Glu Glu Ala Gly Phe Lys Ser Ile His Phe Trp Leu Arg
            340                 345                 350         
Arg Met Pro Asp Ser Lys Asp Asn Arg Ser Val Glu Gly Phe Gly Phe
        355                 360                 365             
Gly Arg Asp Ile Lys Tyr Glu Glu Val Lys Thr Phe Glu Gln Glu Asp
    370                 375                 380                 
Ser Trp Asn Ala Tyr Ile Val Ala Val Ala
385                 390                 


<210> 476
<211> 555
<212> PRT
<213> Ricinus communis

<220> 
<223> casbene synthase Acc. No. EEF48772

<400> 476
Met Ala Glu Lys Asp Lys Tyr Arg Pro Leu Ala Asn Phe Pro Ser Thr
 1               5                  10                  15      
Ala Trp Gly Cys Ser Phe Ala Ser Phe Ser Ser Ser Asn Ser Asp Phe
            20                  25                  30          
Glu Leu Tyr Thr Arg Glu Val Glu Thr Leu Lys Glu Lys Val Arg Pro
        35                  40                  45              
Met Val Thr Ala Ser Thr Lys Asp Pro Leu Glu Asn Val Gln Ile Ile
    50                  55                  60                  
Asn Leu Leu Tyr Arg Leu Gly Val Ser Tyr His Phe Glu Asn Glu Ile
65                  70                  75                  80  
Thr Asp Gln Leu Asn His Ile Phe Glu Ile Ile Pro Asn His Ile Ile
                85                  90                  95      
Ser Asp Asp Asn Asp Tyr Asp Leu Tyr Thr Val Ala Ile Leu Phe Gln
            100                 105                 110         
Ile Leu Arg Gln Tyr Gly His Lys Val Pro Cys Asp Val Phe Asn Lys
        115                 120                 125             
Phe Lys Asn Ser Asp Gly Lys Phe Lys Lys Ser Ile Ala Asn Asp Leu
    130                 135                 140                 
Lys Gly Leu Leu Ser Leu Tyr Glu Ala Ser Phe Leu Ser Val His Gly
145                 150                 155                 160 
Glu Asn Ile Leu Asp Glu Ala Ile Ala Phe Thr Arg Pro Leu Leu Glu
                165                 170                 175     
Ser Phe Ala Asp Gln Ser Ser Pro His Leu Ala Lys Tyr Ile Arg Asn
            180                 185                 190         
Ser Leu Leu Arg Pro His His Gln Gly Ile Gln Arg Val Glu Ala Arg
        195                 200                 205             
Gln Tyr Ile Ser Phe Tyr Glu Glu Asp Glu Ser Arg Asn Glu Thr Leu
    210                 215                 220                 
Leu Lys Phe Ala Lys Leu Asp Phe Asn Arg Leu Gln Leu Leu His Lys
225                 230                 235                 240 
Gln Glu Leu Ala Ser Leu Ser Arg Tyr Lys Lys Tyr Ile Ala Gln Ile
                245                 250                 255     
Ile Ile Trp Glu Asp Leu Asn Leu Ala Lys Glu Leu Pro Tyr Ile Arg
            260                 265                 270         
Asp Arg Leu Val Glu Thr Tyr Leu Trp Ala Ile Gly Ala His Phe Glu
        275                 280                 285             
Pro Gln Tyr Ala Leu Ser Arg Ala Ile Ile Ala Lys Tyr Thr Thr Ile
    290                 295                 300                 
Val Ser Ala Val Asp Asp Thr Tyr Asp Ala Tyr Gly Thr Leu Asp Glu
305                 310                 315                 320 
Leu Gln Arg Phe Thr Asn Ala Phe Gln Arg Cys Asp Ile Asp Ala Ile
                325                 330                 335     
Asp Glu Leu Pro Asp Tyr Met Lys Val Leu Tyr Arg Ala Leu Leu Asn
            340                 345                 350         
Phe Phe Asp Gln Ile Glu Asp Glu Val Asp Glu Gly Arg Ser Tyr Ser
        355                 360                 365             
Thr Ser Val Ala Lys Glu Ala Phe Lys Glu Leu Val Arg Ser Tyr Tyr
    370                 375                 380                 
Val Glu Ala Gln Trp Phe Ser Asp Gly Tyr Val Pro Ser Phe Asp Glu
385                 390                 395                 400 
Tyr Met Arg Asn Gly Leu Ile Thr Ser Thr Tyr Thr Val Leu Pro Ala
                405                 410                 415     
Ala Ser Phe Ile Gly Met Glu Asn Thr Val Gly Glu Lys Glu Tyr Lys
            420                 425                 430         
Trp Val Gln Ser Asn Pro Lys Ile Val Lys Ala Ala Lys Ile Ile Cys
        435                 440                 445             
Arg Leu Met Asp Asp Ile Thr Thr His Glu Asp Glu Gln Lys Arg Gly
    450                 455                 460                 
His Cys Ala Ser Ser Ile Glu Cys Tyr Met Lys Glu Tyr Gly Val Ser
465                 470                 475                 480 
Glu Lys Lys Ala Ile Glu Glu Ile Gln Lys Ile Cys Ala Asn Ala Trp
                485                 490                 495     
Lys Asp Met Asn Glu Glu Cys Met Lys Lys Pro Pro Thr Val Ser Arg
            500                 505                 510         
Thr Leu Leu Lys Tyr Tyr Val Asn Leu Ala Arg Val Ile Asp Phe Val
        515                 520                 525             
Tyr Lys Asn Leu Asp Ser Tyr Thr Tyr Ala Ser Ser Leu Lys Gly Asp
    530                 535                 540                 
Ile Thr Thr Val Phe Leu Glu Leu Leu Pro Val
545                 550                 555 


<210> 477
<211> 601
<212> PRT
<213> Ricinus communis

<220> 
<223> casbeye synthase, chloroplastic synthase Acc. No.
      P59287

<400> 477
Met Ala Leu Pro Ser Ala Ala Met Gln Ser Asn Pro Glu Lys Leu Asn
 1               5                  10                  15      
Leu Phe His Arg Leu Ser Ser Leu Pro Thr Thr Ser Leu Glu Tyr Gly
            20                  25                  30          
Asn Asn Arg Phe Pro Phe Phe Ser Ser Ser Ala Lys Ser His Phe Lys
        35                  40                  45              
Lys Pro Thr Gln Ala Cys Leu Ser Ser Thr Thr His Gln Glu Val Arg
    50                  55                  60                  
Pro Leu Ala Tyr Phe Pro Pro Thr Val Trp Gly Asn Arg Phe Ala Ser
65                  70                  75                  80  
Leu Thr Phe Asn Pro Ser Glu Phe Glu Ser Tyr Asp Glu Arg Val Ile
                85                  90                  95      
Val Leu Lys Lys Lys Val Lys Asp Ile Leu Ile Ser Ser Thr Ser Asp
            100                 105                 110         
Ser Val Glu Thr Val Ile Leu Ile Asp Leu Leu Cys Arg Leu Gly Val
        115                 120                 125             
Ser Tyr His Phe Glu Asn Asp Ile Glu Glu Leu Leu Ser Lys Ile Phe
    130                 135                 140                 
Asn Ser Gln Pro Asp Leu Val Asp Glu Lys Glu Cys Asp Leu Tyr Thr
145                 150                 155                 160 
Ala Ala Ile Val Phe Arg Val Phe Arg Gln His Gly Phe Lys Met Ser
                165                 170                 175     
Ser Asp Val Phe Ser Lys Phe Lys Asp Ser Asp Gly Lys Phe Lys Glu
            180                 185                 190         
Ser Leu Arg Gly Asp Ala Lys Gly Met Leu Ser Leu Phe Glu Ala Ser
        195                 200                 205             
His Leu Ser Val His Gly Glu Asp Ile Leu Glu Glu Ala Phe Ala Phe
    210                 215                 220                 
Thr Lys Asp Tyr Leu Gln Ser Ser Ala Val Glu Leu Phe Pro Asn Leu
225                 230                 235                 240 
Lys Arg His Ile Thr Asn Ala Leu Glu Gln Pro Phe His Ser Gly Val
                245                 250                 255     
Pro Arg Leu Glu Ala Arg Lys Phe Ile Asp Leu Tyr Glu Ala Asp Ile
            260                 265                 270         
Glu Cys Arg Asn Glu Thr Leu Leu Glu Phe Ala Lys Leu Asp Tyr Asn
        275                 280                 285             
Arg Val Gln Leu Leu His Gln Gln Glu Leu Cys Gln Phe Ser Lys Trp
    290                 295                 300                 
Trp Lys Asp Leu Asn Leu Ala Ser Asp Ile Pro Tyr Ala Arg Asp Arg
305                 310                 315                 320 
Met Ala Glu Ile Phe Phe Trp Ala Val Ala Met Tyr Phe Glu Pro Asp
                325                 330                 335     
Tyr Ala His Thr Arg Met Ile Ile Ala Lys Val Val Leu Leu Ile Ser
            340                 345                 350         
Leu Ile Asp Asp Thr Ile Asp Ala Tyr Ala Thr Met Glu Glu Thr His
        355                 360                 365             
Ile Leu Ala Glu Ala Val Ala Arg Trp Asp Met Ser Cys Leu Glu Lys
    370                 375                 380                 
Leu Pro Asp Tyr Met Lys Val Ile Tyr Lys Leu Leu Leu Asn Thr Phe
385                 390                 395                 400 
Ser Glu Phe Glu Lys Glu Leu Thr Ala Glu Gly Lys Ser Tyr Ser Val
                405                 410                 415     
Lys Tyr Gly Arg Glu Ala Phe Gln Glu Leu Val Arg Gly Tyr Tyr Leu
            420                 425                 430         
Glu Ala Val Trp Arg Asp Glu Gly Lys Ile Pro Ser Phe Asp Asp Tyr
        435                 440                 445             
Leu Tyr Asn Gly Ser Met Thr Thr Gly Leu Pro Leu Val Ser Thr Ala
    450                 455                 460                 
Ser Phe Met Gly Val Gln Glu Ile Thr Gly Leu Asn Glu Phe Gln Trp
465                 470                 475                 480 
Leu Glu Thr Asn Pro Lys Leu Ser Tyr Ala Ser Gly Ala Phe Ile Arg
                485                 490                 495     
Leu Val Asn Asp Leu Thr Ser His Val Thr Glu Gln Gln Arg Gly His
            500                 505                 510         
Val Ala Ser Cys Ile Asp Cys Tyr Met Asn Gln His Gly Val Ser Lys
        515                 520                 525             
Asp Glu Ala Val Lys Ile Leu Gln Lys Met Ala Thr Asp Cys Trp Lys
    530                 535                 540                 
Glu Ile Asn Glu Glu Cys Met Arg Gln Ser Gln Val Ser Val Gly His
545                 550                 555                 560 
Leu Met Arg Ile Val Asn Leu Ala Arg Leu Thr Asp Val Ser Tyr Lys
                565                 570                 575     
Tyr Gly Asp Gly Tyr Thr Asp Ser Gln Gln Leu Lys Gln Phe Val Lys
            580                 585                 590         
Gly Leu Phe Val Asp Pro Ile Ser Ile
        595                 600     


<210> 478
<211> 785
<212> PRT
<213> Salvea sclarea

<220> 
<223> labdenediol diphosphate synthase

<400> 478
Met Thr Ser Val Asn Leu Ser Arg Ala Pro Ala Ala Ile Thr Arg Arg
 1               5                  10                  15      
Arg Leu Gln Leu Gln Pro Glu Phe His Ala Glu Cys Ser Trp Leu Lys
            20                  25                  30          
Ser Ser Ser Lys His Ala Pro Leu Thr Leu Ser Cys Gln Ile Arg Pro
        35                  40                  45              
Lys Gln Leu Ser Gln Ile Ala Glu Leu Arg Val Thr Ser Leu Asp Ala
    50                  55                  60                  
Ser Gln Ala Ser Glu Lys Asp Ile Ser Leu Val Gln Thr Pro His Lys
65                  70                  75                  80  
Val Glu Val Asn Glu Lys Ile Glu Glu Ser Ile Glu Tyr Val Gln Asn
                85                  90                  95      
Leu Leu Met Thr Ser Gly Asp Gly Arg Ile Ser Val Ser Pro Tyr Asp
            100                 105                 110         
Thr Ala Val Ile Ala Leu Ile Lys Asp Leu Lys Gly Arg Asp Ala Pro
        115                 120                 125             
Gln Phe Pro Ser Cys Leu Glu Trp Ile Ala His His Gln Leu Ala Asp
    130                 135                 140                 
Gly Ser Trp Gly Asp Glu Phe Phe Cys Ile Tyr Asp Arg Ile Leu Asn
145                 150                 155                 160 
Thr Leu Ala Cys Val Val Ala Leu Lys Ser Trp Asn Leu His Ser Asp
                165                 170                 175     
Ile Ile Glu Lys Gly Val Thr Tyr Ile Lys Glu Asn Val His Lys Leu
            180                 185                 190         
Lys Gly Ala Asn Val Glu His Arg Thr Ala Gly Phe Glu Leu Val Val
        195                 200                 205             
Pro Thr Phe Met Gln Met Ala Thr Asp Leu Gly Ile Gln Asp Leu Pro
    210                 215                 220                 
Tyr Asp His Pro Leu Ile Lys Glu Ile Ala Asp Thr Lys Gln Gln Arg
225                 230                 235                 240 
Leu Lys Glu Ile Pro Lys Asp Leu Val Tyr Gln Met Pro Thr Asn Leu
                245                 250                 255     
Leu Tyr Ser Leu Glu Gly Leu Gly Asp Leu Glu Trp Glu Arg Leu Leu
            260                 265                 270         
Lys Leu Gln Ser Gly Asn Gly Ser Phe Leu Thr Ser Pro Ser Ser Thr
        275                 280                 285             
Ala Ala Val Leu Met His Thr Lys Asp Glu Lys Cys Leu Lys Tyr Ile
    290                 295                 300                 
Glu Asn Ala Leu Lys Asn Cys Asp Gly Gly Ala Pro His Thr Tyr Pro
305                 310                 315                 320 
Val Asp Ile Phe Ser Arg Leu Trp Ala Ile Asp Arg Leu Gln Arg Leu
                325                 330                 335     
Gly Ile Ser Arg Phe Phe Gln His Glu Ile Lys Tyr Phe Leu Asp His
            340                 345                 350         
Ile Glu Ser Val Trp Glu Glu Thr Gly Val Phe Ser Gly Arg Tyr Thr
        355                 360                 365             
Lys Phe Ser Asp Ile Asp Asp Thr Ser Met Gly Val Arg Leu Leu Lys
    370                 375                 380                 
Met His Gly Tyr Asp Val Asp Pro Asn Val Leu Lys His Phe Lys Gln
385                 390                 395                 400 
Gln Asp Gly Lys Phe Ser Cys Tyr Ile Gly Gln Ser Val Glu Ser Ala
                405                 410                 415     
Ser Pro Met Tyr Asn Leu Tyr Arg Ala Ala Gln Leu Arg Phe Pro Gly
            420                 425                 430         
Glu Glu Val Leu Glu Glu Ala Thr Lys Phe Ala Phe Asn Phe Leu Gln
        435                 440                 445             
Glu Met Leu Val Lys Asp Arg Leu Gln Glu Arg Trp Val Ile Ser Asp
    450                 455                 460                 
His Leu Phe Asp Glu Ile Lys Leu Gly Leu Lys Met Pro Trp Tyr Ala
465                 470                 475                 480 
Thr Leu Pro Arg Val Glu Ala Ala Tyr Tyr Leu Asp His Tyr Ala Gly
                485                 490                 495     
Ser Gly Asp Val Trp Ile Gly Lys Ser Phe Tyr Arg Met Pro Glu Ile
            500                 505                 510         
Ser Asn Asp Thr Tyr Lys Glu Leu Ala Ile Leu Asp Phe Asn Arg Cys
        515                 520                 525             
Gln Thr Gln His Gln Leu Glu Trp Ile His Met Gln Glu Trp Tyr Asp
    530                 535                 540                 
Arg Cys Ser Leu Ser Glu Phe Gly Ile Ser Lys Arg Glu Leu Leu Arg
545                 550                 555                 560 
Ser Tyr Phe Leu Ala Ala Ala Thr Ile Phe Glu Pro Glu Arg Thr Gln
                565                 570                 575     
Glu Arg Leu Leu Trp Ala Lys Thr Arg Ile Leu Ser Lys Met Ile Thr
            580                 585                 590         
Ser Phe Val Asn Ile Ser Gly Thr Thr Leu Ser Leu Asp Tyr Asn Phe
        595                 600                 605             
Asn Gly Leu Asp Glu Ile Ile Ser Ser Ala Asn Glu Asp Gln Gly Leu
    610                 615                 620                 
Ala Gly Thr Leu Leu Ala Thr Phe His Gln Leu Leu Asp Gly Phe Asp
625                 630                 635                 640 
Ile Tyr Thr Leu His Gln Leu Lys His Val Trp Ser Gln Trp Phe Met
                645                 650                 655     
Lys Val Gln Gln Gly Glu Gly Ser Gly Gly Glu Asp Ala Val Leu Leu
            660                 665                 670         
Ala Asn Thr Leu Asn Ile Cys Ala Gly Leu Asn Glu Asp Val Leu Ser
        675                 680                 685             
Asn Asn Glu Tyr Thr Ala Leu Ser Thr Leu Thr Asn Lys Ile Cys Asn
    690                 695                 700                 
Arg Leu Ala Gln Ile Gln Asp Asn Lys Ile Leu Gln Val Val Asp Gly
705                 710                 715                 720 
Ser Ile Lys Asp Lys Glu Leu Glu Gln Asp Met Gln Ala Leu Val Lys
                725                 730                 735     
Leu Val Leu Gln Glu Asn Gly Gly Ala Val Asp Arg Asn Ile Arg His
            740                 745                 750         
Thr Phe Leu Ser Val Ser Lys Thr Phe Tyr Tyr Asp Ala Tyr His Asp
        755                 760                 765             
Asp Glu Thr Thr Asp Leu His Ile Phe Lys Val Leu Phe Arg Pro Val
    770                 775                 780                 
Val
785 


<210> 479
<211> 784
<212> PRT
<213> Salvea sclarea

<220> 
<223> labdenediol diphosphate synthase

<400> 479
Met Thr Ser Val Asn Leu Ser Arg Ala Pro Ala Ala Ile Ile Arg Arg
 1               5                  10                  15      
Arg Leu Gln Leu Gln Pro Glu Phe His Ala Glu Cys Ser Trp Leu Lys
            20                  25                  30          
Ser Ser Ser Lys His Ala Pro Phe Thr Leu Ser Cys Gln Ile Arg Pro
        35                  40                  45              
Lys Gln Leu Ser Gln Ile Ala Glu Leu Arg Val Thr Ser Leu Asp Ala
    50                  55                  60                  
Ser Gln Ala Ser Glu Lys Asp Ile Ser Leu Val Gln Thr Pro His Lys
65                  70                  75                  80  
Val Glu Val Asn Glu Lys Ile Glu Glu Ser Ile Glu Tyr Val Gln Asn
                85                  90                  95      
Leu Leu Met Thr Ser Gly Asp Gly Arg Ile Ser Val Ser Pro Tyr Asp
            100                 105                 110         
Thr Ala Val Ile Ala Leu Ile Lys Asp Leu Lys Gly Arg Asp Ala Pro
        115                 120                 125             
Gln Phe Pro Ser Cys Leu Glu Trp Ile Ala His His Gln Leu Ala Asp
    130                 135                 140                 
Gly Ser Trp Gly Asp Glu Phe Phe Cys Ile Tyr Asp Arg Ile Leu Asn
145                 150                 155                 160 
Thr Leu Ala Cys Val Val Ala Leu Lys Ser Trp Asn Leu Gln Ser Asp
                165                 170                 175     
Ile Ile Glu Lys Gly Val Thr Tyr Ile Lys Glu Asn Val His Lys Leu
            180                 185                 190         
Lys Gly Ala Asn Val Glu His Arg Thr Ala Gly Phe Glu Leu Val Val
        195                 200                 205             
Pro Thr Phe Met Gln Met Ala Thr Asp Leu Gly Ile Gln Gly Leu Pro
    210                 215                 220                 
Tyr Asp His Pro Leu Ile Lys Glu Ile Ala Asp Thr Lys Gln Gln Arg
225                 230                 235                 240 
Leu Lys Glu Ile Pro Lys Asp Leu Val Tyr Gln Met Pro Thr Asn Leu
                245                 250                 255     
Leu Tyr Ser Leu Glu Gly Leu Gly Asp Leu Glu Trp Glu Arg Leu Leu
            260                 265                 270         
Lys Leu Gln Ser Gly Asn Gly Ser Phe Leu Thr Ser Pro Ser Ser Thr
        275                 280                 285             
Ala Ala Val Leu Met His Thr Lys Asp Glu Lys Cys Leu Lys Tyr Ile
    290                 295                 300                 
Glu Asn Ala Leu Lys Asn Cys Asp Gly Gly Ala Pro His Thr Tyr Pro
305                 310                 315                 320 
Val Asp Ile Phe Ser Arg Leu Trp Ala Ile Asp Arg Leu Gln Arg Leu
                325                 330                 335     
Gly Ile Ser Arg Phe Phe Gln His Glu Ile Lys Tyr Phe Leu Asp His
            340                 345                 350         
Ile Glu Ser Val Trp Glu Glu Thr Gly Val Phe Ser Gly Arg Tyr Thr
        355                 360                 365             
Lys Phe Ser Asp Ile Asp Asp Thr Ser Met Gly Val Arg Leu Leu Lys
    370                 375                 380                 
Met His Gly Tyr Asp Val Asp Pro Asn Val Leu Lys His Phe Lys Gln
385                 390                 395                 400 
Gln Asp Gly Lys Phe Ser Cys Tyr Ile Gly Gln Ser Val Glu Ser Ala
                405                 410                 415     
Ser Pro Met Tyr Asn Leu Tyr Arg Ala Ala Gln Leu Arg Phe Pro Gly
            420                 425                 430         
Glu Glu Val Leu Glu Glu Ala Thr Lys Phe Ala Phe Asn Phe Leu Gln
        435                 440                 445             
Glu Met Leu Val Lys Asp Arg Leu Gln Glu Arg Trp Val Ile Ser Asp
    450                 455                 460                 
His Leu Phe Asp Glu Ile Lys Leu Gly Leu Lys Met Pro Trp Tyr Ala
465                 470                 475                 480 
Thr Leu Pro Arg Val Glu Ala Ala Tyr Tyr Leu Asp His Tyr Ala Gly
                485                 490                 495     
Ser Gly Asp Val Trp Ile Gly Lys Ser Phe Tyr Arg Met Pro Glu Ile
            500                 505                 510         
Ser Asn Asp Thr Tyr Lys Glu Leu Ala Ile Leu Asp Phe Asn Arg Cys
        515                 520                 525             
Gln Thr Gln His Gln Leu Glu Trp Ile Gln Met Gln Glu Trp Tyr Asp
    530                 535                 540                 
Arg Cys Ser Leu Ser Glu Phe Gly Ile Ser Lys Arg Glu Leu Leu Arg
545                 550                 555                 560 
Ser Tyr Phe Leu Ala Ala Ala Thr Ile Phe Glu Pro Glu Arg Thr Gln
                565                 570                 575     
Glu Arg Leu Leu Trp Ala Lys Thr Arg Ile Leu Ser Lys Met Ile Thr
            580                 585                 590         
Ser Phe Val Asn Ile Ser Gly Thr Thr Leu Ser Leu Asp Tyr Asn Phe
        595                 600                 605             
Asn Gly Leu Asp Glu Ile Ile Ser Ala Asn Glu Asp Gln Gly Leu Ala
    610                 615                 620                 
Gly Thr Leu Leu Ala Thr Phe His Gln Leu Leu Asp Gly Phe Asp Ile
625                 630                 635                 640 
Tyr Thr Leu His Gln Leu Lys His Val Trp Ser Gln Trp Phe Met Lys
                645                 650                 655     
Val Gln Gln Gly Glu Gly Ser Gly Gly Glu Asp Ala Val Leu Leu Ala
            660                 665                 670         
Asn Thr Leu Asn Ile Cys Ala Gly Leu Asn Glu Asp Val Leu Ser Asn
        675                 680                 685             
Asn Glu Tyr Thr Ala Leu Ser Thr Leu Thr Asn Lys Ile Cys Asn Arg
    690                 695                 700                 
Leu Ala Gln Ile Gln Asp Asn Lys Ile Leu Gln Val Val Asp Gly Ser
705                 710                 715                 720 
Ile Lys Asp Lys Glu Leu Glu Gln Asp Met Gln Ala Leu Val Lys Leu
                725                 730                 735     
Val Leu Gln Glu Asn Gly Gly Ala Val Asp Arg Asn Ile Arg His Thr
            740                 745                 750         
Phe Leu Ser Val Ser Lys Thr Phe Tyr Tyr Asp Ala Tyr His Asp Asp
        755                 760                 765             
Glu Thr Thr Asp Leu His Ile Phe Lys Val Leu Phe Arg Pro Val Val
    770                 775                 780                 


<210> 480
<211> 575
<212> PRT
<213> Salvea sclarea

<220> 
<223> sclareol synthase

<400> 480
Met Ser Leu Ala Phe Asn Val Gly Val Thr Pro Phe Ser Gly Gln Arg
 1               5                  10                  15      
Val Gly Ser Arg Lys Glu Lys Phe Pro Val Gln Gly Phe Pro Val Thr
            20                  25                  30          
Thr Pro Asn Arg Ser Arg Leu Ile Val Asn Cys Ser Leu Thr Thr Ile
        35                  40                  45              
Asp Phe Met Ala Lys Met Lys Glu Asn Phe Lys Arg Glu Asp Asp Lys
    50                  55                  60                  
Phe Pro Thr Thr Thr Thr Leu Arg Ser Glu Asp Ile Pro Ser Asn Leu
65                  70                  75                  80  
Cys Ile Ile Asp Thr Leu Gln Arg Leu Gly Val Asp Gln Phe Phe Gln
                85                  90                  95      
Tyr Glu Ile Asn Thr Ile Leu Asp Asn Thr Phe Arg Leu Trp Gln Glu
            100                 105                 110         
Lys His Lys Val Ile Tyr Gly Asn Val Thr Thr His Ala Met Ala Phe
        115                 120                 125             
Arg Leu Leu Arg Val Lys Gly Tyr Glu Val Ser Ser Glu Glu Leu Ala
    130                 135                 140                 
Pro Tyr Gly Asn Gln Glu Ala Val Ser Gln Gln Thr Asn Asp Leu Pro
145                 150                 155                 160 
Met Ile Ile Glu Leu Tyr Arg Ala Ala Asn Glu Arg Ile Tyr Glu Glu
                165                 170                 175     
Glu Arg Ser Leu Glu Lys Ile Leu Ala Trp Thr Thr Ile Phe Leu Asn
            180                 185                 190         
Lys Gln Val Gln Asp Asn Ser Ile Pro Asp Lys Lys Leu His Lys Leu
        195                 200                 205             
Val Glu Phe Tyr Leu Arg Asn Tyr Lys Gly Ile Thr Ile Arg Leu Gly
    210                 215                 220                 
Ala Arg Arg Asn Leu Glu Leu Tyr Asp Met Thr Tyr Tyr Gln Ala Leu
225                 230                 235                 240 
Lys Ser Thr Asn Arg Phe Ser Asn Leu Cys Asn Glu Asp Phe Leu Val
                245                 250                 255     
Phe Ala Lys Gln Asp Phe Asp Ile His Glu Ala Gln Asn Gln Lys Gly
            260                 265                 270         
Leu Gln Gln Leu Gln Arg Trp Tyr Ala Asp Cys Arg Leu Asp Thr Leu
        275                 280                 285             
Asn Phe Gly Arg Asp Val Val Ile Ile Ala Asn Tyr Leu Ala Ser Leu
    290                 295                 300                 
Ile Ile Gly Asp His Ala Phe Asp Tyr Val Arg Leu Ala Phe Ala Lys
305                 310                 315                 320 
Thr Ser Val Leu Val Thr Ile Met Asp Asp Phe Phe Asp Cys His Gly
                325                 330                 335     
Ser Ser Gln Glu Cys Asp Lys Ile Ile Glu Leu Val Lys Glu Trp Lys
            340                 345                 350         
Glu Asn Pro Asp Ala Glu Tyr Gly Ser Glu Glu Leu Glu Ile Leu Phe
        355                 360                 365             
Met Ala Leu Tyr Asn Thr Val Asn Glu Leu Ala Glu Arg Ala Arg Val
    370                 375                 380                 
Glu Gln Gly Arg Ser Val Lys Glu Phe Leu Val Lys Leu Trp Val Glu
385                 390                 395                 400 
Ile Leu Ser Ala Phe Lys Ile Glu Leu Asp Thr Trp Ser Asn Gly Thr
                405                 410                 415     
Gln Gln Ser Phe Asp Glu Tyr Ile Ser Ser Ser Trp Leu Ser Asn Gly
            420                 425                 430         
Ser Arg Leu Thr Gly Leu Leu Thr Met Gln Phe Val Gly Val Lys Leu
        435                 440                 445             
Ser Asp Glu Met Leu Met Ser Glu Glu Cys Thr Asp Leu Ala Arg His
    450                 455                 460                 
Val Cys Met Val Gly Arg Leu Leu Asn Asp Val Cys Ser Ser Glu Arg
465                 470                 475                 480 
Glu Arg Glu Glu Asn Ile Ala Gly Lys Ser Tyr Ser Ile Leu Leu Ala
                485                 490                 495     
Thr Glu Lys Asp Gly Arg Lys Val Ser Glu Asp Glu Ala Ile Ala Glu
            500                 505                 510         
Ile Asn Glu Met Val Glu Tyr His Trp Arg Lys Val Leu Gln Ile Val
        515                 520                 525             
Tyr Lys Lys Glu Ser Ile Leu Pro Arg Arg Cys Lys Asp Val Phe Leu
    530                 535                 540                 
Glu Met Ala Lys Gly Thr Phe Tyr Ala Tyr Gly Ile Asn Asp Glu Leu
545                 550                 555                 560 
Thr Ser Pro Gln Gln Ser Lys Glu Asp Met Lys Ser Phe Val Phe
                565                 570                 575 


<210> 481
<211> 551
<212> PRT
<213> Santalum album

<220> 
<223> santalene synthase

<400> 481
Met Ser Thr Gln Gln Val Ser Ser Glu Asn Ile Val Arg Asn Ala Ala
 1               5                  10                  15      
Asn Phe His Pro Asn Ile Trp Gly Asn His Phe Leu Thr Cys Pro Ser
            20                  25                  30          
Gln Thr Ile Asp Ser Trp Thr Gln Gln His His Lys Glu Leu Lys Glu
        35                  40                  45              
Glu Val Arg Lys Met Met Val Ser Asp Ala Asn Lys Pro Ala Gln Arg
    50                  55                  60                  
Leu Arg Leu Ile Asp Thr Val Gln Arg Leu Gly Val Ala Tyr His Phe
65                  70                  75                  80  
Glu Lys Glu Ile Asp Asp Ala Leu Glu Lys Ile Gly His Asp Pro Phe
                85                  90                  95      
Asp Asp Lys Asp Asp Leu Tyr Ile Val Ser Leu Cys Phe Arg Leu Leu
            100                 105                 110         
Arg Gln His Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys
        115                 120                 125             
Asp Asp Asp Gly Lys Phe Lys Ala Ser Leu Met Asn Asp Val Gln Gly
    130                 135                 140                 
Met Leu Ser Leu Tyr Glu Ala Ala His Leu Ala Ile His Gly Glu Asp
145                 150                 155                 160 
Ile Leu Asp Glu Ala Ile Val Phe Thr Thr Thr His Leu Lys Ser Thr
                165                 170                 175     
Val Ser Asn Ser Pro Val Asn Ser Thr Phe Ala Glu Gln Ile Arg His
            180                 185                 190         
Ser Leu Arg Val Pro Leu Arg Lys Ala Val Pro Arg Leu Glu Ser Arg
        195                 200                 205             
Tyr Phe Leu Asp Ile Tyr Ser Arg Asp Asp Leu His Asp Lys Thr Leu
    210                 215                 220                 
Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Gln Ala Met His Gln
225                 230                 235                 240 
Lys Glu Ala Ser Glu Met Thr Arg Trp Trp Arg Asp Phe Asp Phe Leu
                245                 250                 255     
Lys Lys Leu Pro Tyr Ile Arg Asp Arg Val Val Glu Leu Tyr Phe Trp
            260                 265                 270         
Ile Leu Val Gly Val Ser Tyr Gln Pro Lys Phe Ser Thr Gly Arg Ile
        275                 280                 285             
Phe Leu Ser Lys Ile Ile Cys Leu Glu Thr Leu Val Asp Asp Thr Phe
    290                 295                 300                 
Asp Ala Tyr Gly Thr Phe Asp Glu Leu Ala Ile Phe Thr Glu Ala Val
305                 310                 315                 320 
Thr Arg Trp Asp Leu Gly His Arg Asp Ala Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Phe Ile Phe Lys Thr Leu Ile Asp Val Tyr Ser Glu Ala Glu Gln Glu
            340                 345                 350         
Leu Ala Lys Glu Gly Arg Ser Tyr Ser Ile His Tyr Ala Ile Arg Ser
        355                 360                 365             
Phe Gln Glu Leu Val Met Lys Tyr Phe Cys Glu Ala Lys Trp Leu Asn
    370                 375                 380                 
Lys Gly Tyr Val Pro Ser Leu Asp Asp Tyr Lys Ser Val Ser Leu Arg
385                 390                 395                 400 
Ser Ile Gly Phe Leu Pro Ile Ala Val Ala Ser Phe Val Phe Met Gly
                405                 410                 415     
Asp Ile Ala Thr Lys Glu Val Phe Glu Trp Glu Met Asn Asn Pro Lys
            420                 425                 430         
Ile Ile Ile Ala Ala Glu Thr Ile Phe Arg Phe Leu Asp Asp Ile Ala
        435                 440                 445             
Gly His Arg Phe Glu Gln Lys Arg Glu His Ser Pro Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Lys Asn Gln His Gly Val Ser Glu Glu Glu Ala Val Lys Ala
465                 470                 475                 480 
Leu Ser Leu Glu Val Ala Asn Ser Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Leu Leu Asn Pro Met Ala Ile Pro Leu Pro Leu Leu Gln Val Ile Leu
            500                 505                 510         
Asp Leu Ser Arg Ser Ala Asp Phe Met Tyr Gly Asn Ala Gln Asp Arg
        515                 520                 525             
Phe Thr His Ser Thr Met Met Lys Asp Gln Val Asp Leu Val Leu Lys
    530                 535                 540                 
Asp Pro Val Lys Leu Asp Asp
545                 550     


<210> 482
<211> 548
<212> PRT
<213> Santalum album

<220> 
<223> santalene synthase

<400> 482
Met Ala Thr Asp Asn Asp Ser Ser Glu Asn Arg Arg Met Gly Asn Tyr
 1               5                  10                  15      
Lys Pro Ser Ile Trp Asn Tyr Asp Phe Leu Gln Ser Leu Ala Thr Arg
            20                  25                  30          
His Asn Ile Met Glu Glu Arg His Leu Lys Leu Ala Glu Lys Leu Lys
        35                  40                  45              
Gly Gln Val Lys Phe Met Phe Gly Ala Pro Met Glu Pro Leu Ala Lys
    50                  55                  60                  
Leu Glu Leu Val Asp Val Val Gln Arg Leu Gly Leu Asn His Arg Phe
65                  70                  75                  80  
Glu Thr Glu Ile Lys Glu Ala Leu Phe Ser Ile Tyr Lys Asp Glu Ser
                85                  90                  95      
Asn Gly Trp Trp Phe Gly His Leu His Ala Thr Ser Leu Arg Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Cys Gly Leu Phe Ile Pro Gln Asp Val Phe Lys Thr
        115                 120                 125             
Phe Gln Ser Lys Thr Gly Glu Phe Asp Met Lys Leu Cys Asp Asn Val
    130                 135                 140                 
Lys Gly Leu Leu Ser Leu Tyr Glu Ala Ser Phe Leu Gly Trp Arg Asp
145                 150                 155                 160 
Glu Asn Ile Leu Asp Glu Ala Lys Ala Phe Ala Thr Lys Tyr Leu Lys
                165                 170                 175     
Asn Ala Trp Glu Asn Ile Ser Gln Lys Trp Leu Ala Lys Arg Val Lys
            180                 185                 190         
His Ala Leu Ala Leu Pro Leu His Trp Arg Val Pro Arg Ile Glu Ala
        195                 200                 205             
Arg Trp Phe Val Glu Ala Tyr Gly Glu Glu Glu Asn Met Asn Pro Thr
    210                 215                 220                 
Leu Leu Lys Leu Ala Lys Leu Asp Phe Asn Met Val Gln Ser Ile His
225                 230                 235                 240 
Gln Lys Glu Ile Gly Glu Leu Ala Arg Trp Trp Val Thr Thr Gly Leu
                245                 250                 255     
Asp Lys Leu Ala Phe Ala Arg Asn Asn Leu Leu Gln Ser Tyr Met Trp
            260                 265                 270         
Ser Cys Ala Ile Ala Ser Asp Pro Lys Phe Lys Leu Ala Arg Glu Thr
        275                 280                 285             
Ile Val Glu Ile Gly Ser Val Leu Thr Val Val Asp Asp Ala Tyr Asp
    290                 295                 300                 
Val Tyr Gly Ser Met Asp Glu Leu Asp Leu Tyr Thr Asn Ser Val Glu
305                 310                 315                 320 
Arg Trp Ser Cys Thr Glu Ile Asp Lys Leu Pro Asn Thr Leu Lys Leu
                325                 330                 335     
Ile Phe Met Ala Met Phe Asn Lys Thr Asn Glu Val Gly Leu Arg Val
            340                 345                 350         
Gln His Glu Arg Gly Tyr Ser Gly Ile Thr Thr Phe Ile Lys Ala Trp
        355                 360                 365             
Val Glu Gln Cys Lys Ser Tyr Gln Lys Glu Ala Arg Trp Tyr His Gly
    370                 375                 380                 
Gly His Thr Pro Pro Leu Glu Glu Tyr Ser Leu Asn Gly Leu Val Ser
385                 390                 395                 400 
Ile Gly Phe Pro Leu Leu Leu Ile Thr Gly Tyr Val Ala Ile Ala Glu
                405                 410                 415     
Asn Glu Ala Ala Leu Asp Lys Val His Pro Leu Pro Asp Leu Leu His
            420                 425                 430         
Tyr Ser Ser Leu Leu Ser Arg Leu Ile Asn Asp Met Gly Thr Ser Ser
        435                 440                 445             
Asp Glu Leu Glu Arg Gly Asp Asn Leu Lys Ser Ile Gln Cys Tyr Met
    450                 455                 460                 
Asn Gln Thr Gly Ala Ser Glu Lys Val Ala Arg Glu His Ile Lys Gly
465                 470                 475                 480 
Ile Ile Glu Glu Asn Trp Lys Ile Leu Asn Glu Cys Cys Phe Asp Gln
                485                 490                 495     
Ser Gln Phe Gln Glu Pro Phe Val Thr Phe Asn Leu Asn Ser Val Arg
            500                 505                 510         
Gly Ser His Phe Phe Tyr Glu Phe Gly Asp Gly Phe Gly Val Thr Asn
        515                 520                 525             
Ser Trp Thr Lys Val Asp Met Lys Ser Val Leu Ile Asp Pro Ile Pro
    530                 535                 540                 
Leu Asp Glu Glu
545             


<210> 483
<211> 551
<212> PRT
<213> Santalum album

<220> 
<223> santalene synthase

<400> 483
Met Ala Thr Leu Lys Thr Asp Thr Asp Ala Ser Glu Asn Arg Arg Met
 1               5                  10                  15      
Gly Asn Tyr Lys Pro Ser Ile Trp Asn Tyr Asp Phe Leu Gln Ser Leu
            20                  25                  30          
Ala Thr His His Asn Ile Val Glu Glu Arg His Leu Lys Leu Ala Glu
        35                  40                  45              
Lys Leu Lys Gly Gln Val Lys Phe Met Phe Gly Ala Pro Met Glu Pro
    50                  55                  60                  
Leu Ala Lys Leu Glu Leu Val Asp Val Val Gln Arg Leu Gly Leu Asn
65                  70                  75                  80  
His Leu Phe Glu Thr Glu Ile Lys Glu Ala Leu Phe Ser Ile Tyr Lys
                85                  90                  95      
Asp Gly Ser Asn Gly Trp Trp Phe Gly His Leu His Ala Thr Ser Leu
            100                 105                 110         
Arg Phe Arg Leu Leu Arg Gln Cys Gly Leu Phe Ile Pro Gln Asp Val
        115                 120                 125             
Phe Lys Thr Phe Gln Asn Lys Thr Gly Glu Phe Asp Met Lys Leu Trp
    130                 135                 140                 
Asp Asn Val Lys Gly Leu Leu Ser Leu Tyr Glu Ala Ser Tyr Leu Gly
145                 150                 155                 160 
Trp Lys Gly Glu Asn Ile Leu Asp Glu Ala Lys Ala Phe Thr Thr Lys
                165                 170                 175     
Cys Leu Lys Ser Ala Trp Glu Asn Ile Ser Glu Lys Trp Leu Ala Lys
            180                 185                 190         
Arg Val Lys His Ala Leu Ala Leu Pro Leu His Trp Arg Val Pro Arg
        195                 200                 205             
Ile Glu Ala Arg Trp Phe Ile Glu Val Tyr Glu Gln Glu Ala Asn Met
    210                 215                 220                 
Asn Pro Thr Leu Leu Lys Leu Ala Lys Leu Asp Phe Asn Met Val Gln
225                 230                 235                 240 
Ser Ile His Gln Lys Glu Ile Gly Glu Leu Ala Arg Trp Trp Val Thr
                245                 250                 255     
Thr Gly Leu Asp Lys Leu Asp Phe Ala Arg Asn Asn Leu Leu Gln Ser
            260                 265                 270         
Tyr Met Trp Ser Cys Ala Ile Ala Ser Asp Pro Lys Phe Lys Leu Ala
        275                 280                 285             
Arg Glu Thr Ile Val Glu Ile Gly Ser Val Leu Thr Val Val Asp Asp
    290                 295                 300                 
Gly Tyr Asp Val Tyr Gly Ser Met Asp Glu Leu Asp Leu Tyr Thr Ser
305                 310                 315                 320 
Ser Val Glu Arg Trp Ser Cys Val Lys Ile Asp Lys Leu Pro Asn Thr
                325                 330                 335     
Leu Lys Leu Ile Phe Met Ser Met Phe Asn Lys Thr Asn Glu Val Gly
            340                 345                 350         
Leu Arg Val Gln His Glu Arg Gly Tyr Asn Ser Ile Pro Thr Phe Ile
        355                 360                 365             
Lys Ala Trp Val Glu Gln Cys Lys Ser Tyr Gln Lys Glu Ala Arg Trp
    370                 375                 380                 
Phe His Gly Gly His Thr Pro Pro Leu Glu Glu Tyr Ser Leu Asn Gly
385                 390                 395                 400 
Leu Val Ser Ile Gly Phe Pro Leu Leu Leu Ile Thr Gly Tyr Val Ala
                405                 410                 415     
Ile Ala Glu Asn Glu Ala Ala Leu Asp Lys Val His Pro Leu Pro Asp
            420                 425                 430         
Leu Leu His Tyr Ser Ser Leu Leu Ser Arg Leu Ile Asn Asp Ile Gly
        435                 440                 445             
Thr Ser Pro Asp Glu Met Ala Arg Gly Asp Asn Leu Lys Ser Ile His
    450                 455                 460                 
Cys Tyr Met Asn Glu Thr Gly Ala Ser Glu Glu Val Ala Arg Glu His
465                 470                 475                 480 
Ile Lys Gly Val Ile Glu Glu Asn Trp Lys Ile Leu Asn Gln Cys Cys
                485                 490                 495     
Phe Asp Gln Ser Gln Phe Gln Glu Pro Phe Ile Thr Phe Asn Leu Asn
            500                 505                 510         
Ser Val Arg Gly Ser His Phe Phe Tyr Glu Phe Gly Asp Gly Phe Gly
        515                 520                 525             
Val Thr Asp Ser Trp Thr Lys Val Asp Met Lys Ser Val Leu Ile Asp
    530                 535                 540                 
Pro Ile Pro Leu Gly Glu Glu
545                 550     


<210> 484
<211> 569
<212> PRT
<213> Santalum album

<220> 
<223> santalene synthase

<400> 484
Met Asp Ser Ser Thr Ala Thr Ala Met Arg Ala Pro Phe Ile Asp His
 1               5                  10                  15      
Thr Asp His Val Asn Leu Arg Thr Asp Asn Asp Ser Ser Glu Asn Arg
            20                  25                  30          
Arg Met Gly Asn Tyr Lys Pro Ser Ile Trp Asn Tyr Asp Phe Leu Gln
        35                  40                  45              
Ser Leu Ala Thr Arg His Asn Ile Met Glu Glu Arg His Leu Lys Leu
    50                  55                  60                  
Ala Glu Lys Leu Lys Gly Gln Val Lys Phe Met Phe Gly Ala Pro Met
65                  70                  75                  80  
Glu Pro Leu Ala Lys Leu Glu Leu Val Asp Val Val Gln Arg Leu Gly
                85                  90                  95      
Leu Asn His Arg Phe Glu Thr Glu Ile Lys Glu Ala Leu Phe Ser Ile
            100                 105                 110         
Tyr Lys Asp Glu Ser Asn Gly Trp Trp Phe Gly His Leu His Ala Thr
        115                 120                 125             
Ser Leu Arg Phe Arg Leu Leu Arg Gln Cys Gly Leu Phe Ile Pro Gln
    130                 135                 140                 
Asp Val Phe Lys Thr Phe Gln Ser Lys Thr Gly Glu Phe Asp Met Lys
145                 150                 155                 160 
Leu Cys Asp Asn Val Lys Gly Leu Leu Ser Leu Tyr Glu Ala Ser Phe
                165                 170                 175     
Leu Gly Trp Arg Asp Glu Asn Ile Leu Asp Glu Ala Lys Ala Phe Ala
            180                 185                 190         
Thr Lys Tyr Leu Lys Asn Ala Trp Glu Asn Ile Ser Gln Lys Trp Leu
        195                 200                 205             
Ala Lys Arg Val Lys His Ala Leu Ala Leu Pro Leu His Trp Arg Val
    210                 215                 220                 
Pro Arg Ile Glu Ala Arg Trp Phe Val Glu Ala Tyr Gly Glu Glu Glu
225                 230                 235                 240 
Asn Met Asn Pro Thr Leu Leu Lys Leu Ala Lys Leu Asp Phe Asn Met
                245                 250                 255     
Val Gln Ser Ile His Gln Lys Glu Ile Gly Glu Leu Ala Arg Trp Trp
            260                 265                 270         
Val Thr Thr Gly Leu Asp Lys Leu Ala Phe Ala Arg Asn Asn Leu Leu
        275                 280                 285             
Gln Ser Tyr Met Trp Ser Cys Ala Ile Ala Ser Asp Pro Lys Phe Lys
    290                 295                 300                 
Leu Ala Arg Glu Thr Ile Val Glu Ile Gly Ser Val Leu Thr Val Val
305                 310                 315                 320 
Asp Asp Ala Tyr Asp Val Tyr Gly Ser Met Asp Glu Leu Asp Leu Tyr
                325                 330                 335     
Thr Asn Ser Val Glu Arg Trp Ser Cys Thr Glu Ile Asp Lys Leu Pro
            340                 345                 350         
Asn Thr Leu Lys Leu Ile Phe Met Ser Met Phe Asn Lys Thr Asn Glu
        355                 360                 365             
Val Gly Leu Arg Val Gln His Glu Arg Gly Tyr Ser Gly Ile Thr Thr
    370                 375                 380                 
Phe Ile Lys Ala Trp Val Glu Gln Cys Lys Ser Tyr Gln Lys Glu Ala
385                 390                 395                 400 
Arg Trp Tyr His Gly Gly His Thr Pro Pro Leu Glu Glu Tyr Ser Leu
                405                 410                 415     
Asn Gly Leu Val Ser Ile Gly Phe Pro Leu Leu Leu Ile Thr Gly Tyr
            420                 425                 430         
Val Ala Ile Ala Glu Asn Glu Ala Ala Leu Asp Lys Val His Pro Leu
        435                 440                 445             
Pro Asp Leu Leu His Tyr Ser Ser Leu Leu Ser Arg Leu Ile Asn Asp
    450                 455                 460                 
Met Gly Thr Ser Ser Asp Glu Leu Glu Arg Gly Asp Asn Leu Lys Ser
465                 470                 475                 480 
Ile Gln Cys Tyr Met Asn Gln Thr Gly Ala Ser Glu Lys Val Ala Arg
                485                 490                 495     
Glu His Ile Lys Gly Ile Ile Glu Glu Asn Trp Lys Ile Leu Asn Glu
            500                 505                 510         
Cys Cys Phe Asp Gln Ser Gln Phe Gln Glu Pro Phe Val Thr Phe Asn
        515                 520                 525             
Leu Asn Ser Val Arg Gly Ser His Phe Phe Tyr Glu Phe Gly Asp Gly
    530                 535                 540                 
Phe Gly Val Thr Asp Ser Trp Thr Lys Val Asp Met Lys Ser Val Leu
545                 550                 555                 560 
Ile Asp Pro Ile Pro Leu Asp Glu Glu
                565                 


<210> 485
<211> 569
<212> PRT
<213> Santalum album

<220> 
<223> santalene synthase

<400> 485
Met Asp Ser Ser Thr Ala Thr Ala Met Thr Ala Pro Phe Ile Asp Pro
 1               5                  10                  15      
Thr Asp His Val Asn Leu Lys Thr Asp Thr Asp Ala Ser Glu Asn Arg
            20                  25                  30          
Arg Met Gly Asn Tyr Lys Pro Ser Ile Trp Asn Tyr Asp Phe Leu Gln
        35                  40                  45              
Ser Leu Ala Thr His His Asn Ile Val Glu Glu Arg His Leu Lys Leu
    50                  55                  60                  
Ala Glu Lys Leu Lys Gly Gln Val Lys Phe Met Phe Gly Ala Pro Met
65                  70                  75                  80  
Glu Pro Leu Ala Lys Leu Glu Leu Val Asp Val Val Gln Arg Leu Gly
                85                  90                  95      
Leu Asn His Leu Phe Glu Thr Glu Ile Lys Glu Ala Leu Phe Ser Ile
            100                 105                 110         
Tyr Lys Asp Gly Ser Asn Gly Trp Trp Phe Gly His Leu His Ala Thr
        115                 120                 125             
Ser Leu Arg Phe Arg Leu Leu Arg Gln Cys Gly Leu Phe Ile Pro Gln
    130                 135                 140                 
Asp Val Phe Lys Thr Phe Gln Asn Lys Thr Gly Glu Phe Asp Met Lys
145                 150                 155                 160 
Leu Trp Asp Asn Val Lys Gly Leu Leu Ser Leu Tyr Glu Ala Ser Tyr
                165                 170                 175     
Leu Gly Trp Lys Gly Glu Asn Ile Leu Asp Glu Ala Lys Ala Phe Thr
            180                 185                 190         
Thr Lys Cys Leu Lys Ser Ala Trp Glu Asn Ile Ser Glu Lys Trp Leu
        195                 200                 205             
Ala Lys Arg Val Lys His Ala Leu Ala Leu Pro Leu His Trp Arg Val
    210                 215                 220                 
Pro Arg Ile Glu Ala Arg Trp Phe Ile Glu Val Tyr Glu Gln Glu Ala
225                 230                 235                 240 
Asn Met Asn Pro Thr Leu Leu Lys Leu Ala Lys Leu Asp Phe Asn Met
                245                 250                 255     
Val Gln Ser Ile His Gln Lys Glu Ile Gly Glu Leu Ala Arg Trp Trp
            260                 265                 270         
Val Thr Thr Gly Leu Asp Lys Leu Asp Phe Ala Arg Asn Asn Leu Leu
        275                 280                 285             
Gln Ser Tyr Met Trp Ser Cys Pro Ile Ala Ser Asp Pro Lys Phe Lys
    290                 295                 300                 
Leu Ala Arg Glu Thr Ile Val Glu Ile Gly Ser Val Leu Thr Val Val
305                 310                 315                 320 
Asp Asp Gly Tyr Asp Val Tyr Gly Ser Met Asp Glu Leu Asp Leu Tyr
                325                 330                 335     
Thr Ser Ser Val Glu Arg Trp Ser Cys Val Lys Ile Asp Lys Leu Pro
            340                 345                 350         
Asn Thr Leu Lys Leu Ile Phe Met Ser Met Phe Asn Lys Thr Asn Glu
        355                 360                 365             
Val Gly Leu Arg Val Gln His Glu Arg Gly Tyr Asn Ser Ile Pro Thr
    370                 375                 380                 
Phe Ile Lys Ala Trp Val Glu Gln Cys Lys Ser Tyr Gln Lys Glu Ala
385                 390                 395                 400 
Arg Trp Phe His Gly Gly His Thr Pro Pro Leu Glu Glu Tyr Ser Leu
                405                 410                 415     
Asn Gly Leu Val Ser Ile Gly Phe Pro Leu Leu Leu Ile Thr Gly Tyr
            420                 425                 430         
Val Ala Ile Ala Glu Asn Glu Ala Ala Leu Asp Lys Val His Pro Leu
        435                 440                 445             
Pro Asp Leu Leu His Tyr Ser Ser Leu Leu Ser Arg Leu Ile Asn Asp
    450                 455                 460                 
Ile Gly Thr Ser Pro Asp Glu Met Ala Arg Gly Asp Asn Leu Lys Ser
465                 470                 475                 480 
Ile His Cys Tyr Met Asn Glu Thr Gly Ala Ser Glu Glu Val Ala Arg
                485                 490                 495     
Glu His Ile Lys Gly Val Ile Glu Glu Asn Trp Lys Ile Leu Asn Gln
            500                 505                 510         
Cys Cys Phe Asp Gln Ser Gln Phe Gln Glu Pro Phe Ile Thr Phe Asn
        515                 520                 525             
Leu Asn Ser Val Arg Gly Ser His Phe Phe Tyr Glu Phe Gly Asp Gly
    530                 535                 540                 
Phe Gly Val Thr Asp Ser Trp Thr Lys Val Asp Met Lys Ser Val Leu
545                 550                 555                 560 
Ile Asp Pro Ile Pro Leu Gly Glu Glu
                565                 


<210> 486
<211> 559
<212> PRT
<213> Santalum album

<220> 
<223> sesquiterpene synthase Acc. No. ACF24768

<400> 486
Met Glu Asn Gln Lys Val Pro Ile Ser Ser Val Pro Asn Leu Lys Glu
 1               5                  10                  15      
Leu Ser Arg Pro Ile Ala Asn Phe Pro Pro Ser Ile Trp Gly Asp Arg
            20                  25                  30          
Phe Ile Asn Tyr Ala Cys Glu Asp Glu Asn Glu Gln Ala Gln Lys Glu
        35                  40                  45              
Arg Gln Val Glu Glu Leu Lys Glu Gln Val Arg Arg Glu Leu Ala Ala
    50                  55                  60                  
Thr Val Asp Lys Pro Leu Gln Gln Leu Asn Ile Ile Asp Ala Thr Gln
65                  70                  75                  80  
Arg Leu Gly Ile Ala Tyr His Phe Glu Asn Glu Ile Glu Glu Ser Leu
                85                  90                  95      
Glu His Ile Tyr Leu His Thr Tyr Val Glu Asn Asn Cys Phe Gln Gly
            100                 105                 110         
Ser His Asp Leu Tyr Ser Val Ala Leu Trp Phe Arg Leu Leu Arg Gln
        115                 120                 125             
Asp Gly Tyr Lys Val Ser Cys Asp Val Phe Asp Lys Phe Arg Asp Tyr
    130                 135                 140                 
Glu Asp Asn Phe Lys Asn Ser Leu Met Glu Asp Ala Lys Gly Leu Leu
145                 150                 155                 160 
Glu Leu Tyr Glu Ala Thr His Leu Ser Val His Gly Glu Glu Met Leu
                165                 170                 175     
Asp Asp Ala Leu Glu Phe Ala Lys Thr Arg Leu Glu Ser Ile Val Asn
            180                 185                 190         
His Leu Asn Tyr Pro Leu Ala Glu Gln Val Arg His Ala Leu Tyr Arg
        195                 200                 205             
Pro Leu Arg Lys Gly Leu Pro Arg Leu Glu Ala Val Tyr Phe Phe Arg
    210                 215                 220                 
Ile Tyr Glu Ala Tyr Asp Ser His Asn Lys Ala Leu Leu Lys Leu Ala
225                 230                 235                 240 
Lys Leu Asp Phe Asn Leu Leu Gln Ser Leu His Lys Lys Glu Leu Ser
                245                 250                 255     
Asp Met Ala Arg Trp Trp Lys Ser Leu Asp Phe Ala Ala Lys Phe Pro
            260                 265                 270         
Phe Ala Arg Asp Arg Leu Val Glu Gly Tyr Phe Trp Val Leu Gly Val
        275                 280                 285             
Tyr Phe Glu Pro Gln Tyr Ser Leu Ala Arg Lys Ile Ile Ile Lys Val
    290                 295                 300                 
Phe Thr Met Ile Ser Thr Ile Asp Asp Ile Tyr Asp Ala Tyr Gly Thr
305                 310                 315                 320 
Leu Asp Glu Leu Glu Leu Phe Thr Lys Ala Met Gln Arg Trp Asp Val
                325                 330                 335     
Gly Ser Leu Asp Gln Leu Pro Glu Tyr Met Lys Pro Cys Tyr Lys Ser
            340                 345                 350         
Ile Leu Asp Val Tyr Asn Glu Ile Glu Glu Glu Met Asp Asn Gln Gly
        355                 360                 365             
Ser Leu Phe Arg Met His Tyr Ala Lys Glu Val Met Lys Lys Leu Val
    370                 375                 380                 
Glu Gly Tyr Met Asp Glu Ala Lys Trp Cys His Glu Lys Tyr Val Pro
385                 390                 395                 400 
Thr Phe Glu Glu Tyr Met Pro Val Ala Leu Val Thr Ser Gly Tyr Thr
                405                 410                 415     
Phe Leu Thr Thr Ile Ser Tyr Leu Gly Met Gly Glu Ile Ala Ser Lys
            420                 425                 430         
Glu Ala Phe Asp Trp Leu Phe Ser His Pro Pro Val Ile Glu Ala Ser
        435                 440                 445             
Glu Ser Val Cys Arg Leu Met Asp Asp Met Arg Ser His Lys Phe Glu
    450                 455                 460                 
Gln Glu Arg Gly His Val Ala Ser Gly Ile Glu Cys Tyr Met Lys Gln
465                 470                 475                 480 
Tyr Gly Val Thr Glu Glu Glu Ala His Asp Glu Phe Arg Lys Gln Leu
                485                 490                 495     
Val Lys Ala Trp Lys Asp Ile Asn Glu Glu Cys Leu Arg Pro Tyr Arg
            500                 505                 510         
Val Pro Lys Pro Leu Leu Met Arg Ile Leu Asn Leu Thr Arg Val Ile
        515                 520                 525             
Asp Val Ile Tyr Lys Asn Glu Asp Gly Tyr Thr His Val Lys Lys Ala
    530                 535                 540                 
Met Lys Asp Asn Ile Ala Ser Leu Leu Ile Asp Pro Met Ile Val
545                 550                 555                 


<210> 487
<211> 559
<212> PRT
<213> Santalum austrocaledonicum

<220> 
<223> sesquiterpene synthase Acc. No. ADO87005

<400> 487
Met Glu Asn Gln Lys Val Pro Ile Ser Ser Val Pro Asn Leu Lys Glu
 1               5                  10                  15      
Leu Ser Arg Pro Ile Ala Asn Phe Pro Pro Ser Ile Trp Gly Asp Arg
            20                  25                  30          
Phe Ile Asn Tyr Thr Cys Glu Asp Glu Asn Glu Gln Ala Gln Lys Glu
        35                  40                  45              
Arg Gln Val Glu Glu Leu Lys Glu Gln Val Arg Arg Glu Leu Ala Ala
    50                  55                  60                  
Thr Val Asp Lys Pro Leu Gln Gln Leu Asn Ile Ile Asp Ala Thr Gln
65                  70                  75                  80  
Arg Leu Gly Ile Ala Tyr His Phe Glu Asn Glu Ile Glu Glu Ser Leu
                85                  90                  95      
Glu His Ile Tyr Leu His Thr Tyr Val Lys Asn Asn Cys Phe Gln Gly
            100                 105                 110         
Ser His Asp Leu Tyr Ser Val Ala Leu Trp Phe Arg Leu Leu Arg Gln
        115                 120                 125             
Asp Gly Tyr Lys Val Ser Cys Asp Val Phe Asp Asn Phe Arg Asp Tyr
    130                 135                 140                 
Glu Gly Asn Phe Lys Asn Ser Leu Met Glu Asp Ala Lys Gly Leu Leu
145                 150                 155                 160 
Glu Leu Tyr Glu Ala Thr His Leu Ser Val His Gly Glu Glu Met Leu
                165                 170                 175     
Asp Asp Ala Leu Glu Phe Ala Lys Thr Arg Leu Glu Ser Ile Val Asn
            180                 185                 190         
His Leu Asn Tyr Pro Leu Ala Glu Gln Val Arg His Ala Leu Tyr Arg
        195                 200                 205             
Pro Leu Arg Lys Gly Leu Pro Arg Leu Glu Ala Val Tyr Phe Phe Arg
    210                 215                 220                 
Ile Tyr Glu Ala Tyr His Ser His Asn Lys Ala Leu Leu Lys Leu Ala
225                 230                 235                 240 
Lys Leu Asp Phe Asn Leu Leu Gln Ser Leu His Arg Lys Glu Leu Gly
                245                 250                 255     
Asp Met Ala Arg Trp Trp Arg Ser Leu Asp Phe Ala Thr Lys Phe Pro
            260                 265                 270         
Phe Ala Arg Asp Arg Leu Val Glu Gly Tyr Phe Trp Ile Leu Gly Val
        275                 280                 285             
Tyr Phe Glu Pro Gln Tyr Ser Leu Ala Arg Glu Ile Thr Thr Lys Val
    290                 295                 300                 
Phe Ala Met Ile Ser Thr Ile Asp Asp Ile Tyr Asp Ala Tyr Gly Thr
305                 310                 315                 320 
Leu Asp Glu Leu Lys Leu Phe Thr Glu Ala Ile Gln Arg Trp Asp Val
                325                 330                 335     
Gly Ser Leu Asp Gln Leu Pro Glu Tyr Met Lys Pro Cys Tyr Lys Ser
            340                 345                 350         
Ile Leu Asp Val Tyr Asn Glu Ile Glu Glu Glu Met Ala Asn Gln Gly
        355                 360                 365             
Ser Leu Phe Arg Met His Tyr Ala Lys Glu Val Met Lys Thr Ile Val
    370                 375                 380                 
Glu Gly Tyr Met Asp Glu Ala Lys Trp Cys His Glu Lys Tyr Val Pro
385                 390                 395                 400 
Thr Phe Gln Glu Tyr Met Ser Leu Ala Leu Val Thr Ser Gly Tyr Thr
                405                 410                 415     
Phe Leu Thr Thr Ile Ser Tyr Leu Gly Met Gly Gly Ile Ala Ser Lys
            420                 425                 430         
Glu Ala Phe Glu Trp Leu Phe Ser His Pro Pro Ile Ile Glu Ala Ser
        435                 440                 445             
Glu Ser Ile Cys Arg Leu Met Asp Asp Met Ser Ser His Lys Phe Glu
    450                 455                 460                 
Gln Glu Arg Gly His Val Ala Ser Gly Ile Glu Cys Tyr Met Lys Gln
465                 470                 475                 480 
Tyr Gly Val Ile Glu Glu Glu Ala His Asp Glu Phe His Lys Arg Leu
                485                 490                 495     
Val Lys Ala Trp Lys Asp Ile Asn Glu Gly Phe Leu Arg Pro Tyr Ala
            500                 505                 510         
Val Pro Glu Pro Leu Leu Met Arg Ile Leu Asn Leu Thr Arg Val Met
        515                 520                 525             
Asp Val Ile Tyr Lys Asn Glu Asp Ser Tyr Thr His Val Lys Lys Ala
    530                 535                 540                 
Met Lys Asp Asn Ile Ala Ser Leu Leu Ile Asp Pro Met Ile Val
545                 550                 555                 


<210> 488
<211> 562
<212> PRT
<213> Santalum spicatum

<220> 
<223> sesquiterpene synthase Acc. No. ADO87006

<400> 488
Met Glu Asn Gln Lys Val Pro Ile Ser Ser Val Pro Asn Leu Lys Asp
 1               5                  10                  15      
Leu Asp Met Ile Ser Arg Pro Ile Ala Asn Phe Pro Pro Ser Val Trp
            20                  25                  30          
Gly Asp Arg Phe Ile Asn Tyr Ala Cys Glu Asp Glu Asn Glu Gln Ala
        35                  40                  45              
Gln Lys Glu Arg Gln Val Glu Glu Leu Lys Glu Gln Val Arg Arg Glu
    50                  55                  60                  
Leu Ala Ala Ala Ile Asp Lys Pro Leu Gln Gln Leu Asn Ile Ile Asp
65                  70                  75                  80  
Ala Thr Gln Arg Leu Gly Ile Ala Tyr His Phe Glu Asn Glu Ile Glu
                85                  90                  95      
Glu Ser Leu Lys His Ile Tyr Leu His Thr Tyr Val Glu Asn Thr Cys
            100                 105                 110         
Phe Glu Gly Ser Asp Asp Leu Cys Ser Val Ala Leu Trp Phe Arg Leu
        115                 120                 125             
Leu Arg Gln Asp Gly Tyr Arg Val Ser Cys Asp Val Phe Lys Lys Phe
    130                 135                 140                 
Arg Asp Ser Glu Gly Asn Phe Lys Asn Ser Leu Met Glu Asp Ala Lys
145                 150                 155                 160 
Gly Leu Leu Glu Leu Tyr Glu Ala Thr His Leu Ser Val Asn Gly Glu
                165                 170                 175     
Glu Met Leu Asp Asp Ala Leu Glu Phe Thr Lys Thr His Leu Glu Leu
            180                 185                 190         
Val Val Ser His Leu Asn Tyr Pro Leu Ala Glu Gln Val Arg His Ala
        195                 200                 205             
Leu Tyr Gln Pro Gln His Lys Gly Leu Pro Arg Leu Glu Ala Val Tyr
    210                 215                 220                 
Phe Phe Arg Ile Tyr Glu Ala Tyr Asp Ser His Asn Glu Ala Leu Leu
225                 230                 235                 240 
Lys Leu Ala Lys Leu Asp Phe Asn Leu Leu Gln Ser Leu His Met Lys
                245                 250                 255     
Glu Leu Ser His Met Ala Lys Trp Trp Lys Ser Leu Asp Phe Ala Thr
            260                 265                 270         
Lys Phe Pro Phe Ala Arg Asp Arg Leu Val Glu Gly Tyr Phe Trp Ile
        275                 280                 285             
Leu Gly Val Tyr Phe Glu Pro Gln Tyr Ser Leu Ala Arg Lys Ile Ile
    290                 295                 300                 
Ile Lys Val Phe Thr Met Ile Ser Thr Ile Asp Asp Ile Tyr Asp Ala
305                 310                 315                 320 
Tyr Gly Thr Leu Asp Glu Leu Lys Leu Phe Thr Lys Ala Ile Gln Arg
                325                 330                 335     
Trp Asp Ile Gly Ser Leu Asp Gln Leu Pro Glu Tyr Met Lys Pro Cys
            340                 345                 350         
Tyr Lys Ser Val Leu Asp Val Tyr Asn Glu Ile Glu Glu Glu Met Asp
        355                 360                 365             
Asn Gln Gly Ser Leu Phe Arg Met His Tyr Ala Lys Glu Glu Met Lys
    370                 375                 380                 
Lys Ile Val Glu Gly Tyr Met Asp Glu Ala Lys Trp Cys His Glu Lys
385                 390                 395                 400 
Tyr Val Pro Thr Phe Gln Glu Tyr Met Ser Val Ala Leu Val Thr Ala
                405                 410                 415     
Gly Tyr Thr Phe Leu Thr Thr Ile Ser Tyr Leu Gly Met Gly Glu Ile
            420                 425                 430         
Ala Ser Lys Glu Ala Phe Asp Trp Leu Phe Ser His Pro Pro Ile Ile
        435                 440                 445             
Glu Ala Ser Glu Ser Val Gly Arg Leu Met Asp Asp Met Arg Ser His
    450                 455                 460                 
Glu Phe Glu Gln Glu Arg Gly His Val Ala Ser Gly Ile Glu Cys Tyr
465                 470                 475                 480 
Met Lys Gln Tyr Gly Val Thr Glu Glu Glu Ala His Asp Lys Phe His
                485                 490                 495     
Lys Arg Leu Val Lys Ala Trp Lys Asp Ile Asn Glu Gly Cys Leu Arg
            500                 505                 510         
Pro Tyr Pro Val Pro Lys Pro Leu Leu Met Arg Ile Leu Ser Leu Thr
        515                 520                 525             
Arg Val Ile Asp Val Ile Tyr Lys Asn Glu Asp Trp Tyr Thr His Val
    530                 535                 540                 
Lys Lys Pro Met Lys Asp Lys Ile Ala Ser Leu Leu Ile Asp Pro Met
545                 550                 555                 560 
Ile Val
        


<210> 489
<211> 827
<212> PRT
<213> Scoparia dulcis

<220> 
<223> copalyl disphosphate synthase Acc. No. BAA03594

<400> 489
Met Ala Leu Ala Thr Phe Leu Arg Ser Pro Pro Ser Pro Gly Val Phe
 1               5                  10                  15      
Ala Ala Ala Leu His Val Pro Ser Ser Ser Thr Phe Gly Arg Thr Thr
            20                  25                  30          
Thr Tyr Val Phe Pro Ser Tyr Ser Trp Lys Thr Pro Val Thr Ser Ser
        35                  40                  45              
Asn Thr Ser Pro Cys Asn Ala Ile Ser Arg Pro Arg Thr Glu Glu Arg
    50                  55                  60                  
Ile Asp Leu Ile Arg Asn Gly Phe Pro Thr Ile Asn Tyr Trp His Glu
65                  70                  75                  80  
Ile Val Glu Asp Asp Thr Gln Leu Glu Ile Thr His Arg Glu Thr Ala
                85                  90                  95      
Ile Ser Ser Asn Lys Ile Trp Glu Met Val Lys Thr Ile Arg Gly Met
            100                 105                 110         
Leu Arg Ser Met Glu Asp Gly Glu Ile Thr Val Ser Ala Tyr Asp Thr
        115                 120                 125             
Ala Trp Val Ala Leu Val Glu Asp Ile Gly Gly Ser Gly Thr Pro Gln
    130                 135                 140                 
Phe Pro Ser Ser Leu Glu Trp Ile Ser Asn Asn Gln Leu Pro Asp Gly
145                 150                 155                 160 
Ser Trp Gly Asp Gly Ala Thr Phe Ser Ala His Asp Arg Ile Ile Asn
                165                 170                 175     
Thr Leu Ala Cys Val Ile Ala Leu Arg Thr Trp Asn Met His Ser Asp
            180                 185                 190         
Lys Ser Asp Arg Gly Ile Ala Phe Ile Arg Glu Asn Met Tyr Lys Leu
        195                 200                 205             
Glu Asp Glu Asn Glu Glu His Met Pro Ile Gly Phe Glu Val Ala Leu
    210                 215                 220                 
Pro Ser Leu Ile Glu Ile Ala Lys Lys Ile Asp Ile Asp Ile Pro Asp
225                 230                 235                 240 
Glu Ser Pro Ile Phe Glu Lys Arg Leu Arg Lys Lys Arg Phe Lys Leu
                245                 250                 255     
Lys Arg Ile Pro Arg Asp Ile Met His Lys Val Pro Thr Thr Leu Leu
            260                 265                 270         
His Ser Leu Glu Gly Met Pro Ala Leu Asp Trp Glu Lys Leu Ile Asn
        275                 280                 285             
Leu Gln Ser Ala Asp Gly Ser Phe Leu Phe Ser Pro Ser Ser Thr Ala
    290                 295                 300                 
Phe Ala Leu Gln Gln Thr Lys Asp His Asn Cys Leu His Tyr Pro Ala
305                 310                 315                 320 
Arg His Leu Gln Lys Phe Asn Gly Gly Val Pro Asn Val Tyr Pro Val
                325                 330                 335     
Asp Leu Phe Glu His Leu Trp Ala Val Asp Arg Leu Glu Arg Leu Gly
            340                 345                 350         
Leu Ser Arg Tyr Phe Gln Pro Glu Ile Glu Glu Cys Ile Asp Tyr Val
        355                 360                 365             
His Gly His Trp Thr Ser Lys Gly Ile Cys Trp Ala Arg Asn Ser Glu
    370                 375                 380                 
Val Lys Asp Ile Asp Asp Thr Ala Met Gly Phe Arg Leu Leu Lys Leu
385                 390                 395                 400 
His Gly Tyr Glu Val Ser Ala Asp Val Phe Lys His Phe Glu Asn Gly
                405                 410                 415     
Gly Glu Phe Phe Cys Phe Val Gly Gln Ser Thr Gln Ala Val Thr Gly
            420                 425                 430         
Met Tyr Asn Leu Phe Arg Ala Ser Gln Val Met Phe Pro Gly Glu Asp
        435                 440                 445             
Ile Leu Ser Asn Ala Lys Ser Phe Leu Ser Lys Phe Leu Gln Glu Lys
    450                 455                 460                 
Arg Ala Asn Asn Glu Leu Leu Asp Lys Trp Ile Ile Thr Lys Asp Leu
465                 470                 475                 480 
Pro Gly Glu Val Gly Tyr Ala Leu Asp Val Pro Trp Tyr Ala Ser Leu
                485                 490                 495     
Pro Arg Val Glu Thr Arg Leu Tyr Leu Glu Gln Tyr Gly Gly Gln Asp
            500                 505                 510         
Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met Pro Tyr Val Asn Asn
        515                 520                 525             
Asn Thr Tyr Leu Glu Leu Ala Lys Leu Asp Tyr Asn Asn Cys Gln Ala
    530                 535                 540                 
Ser His Gln Gln Glu Trp Lys Ser Ile Gln Lys Trp Tyr Ser Arg Cys
545                 550                 555                 560 
Asn Phe Gly Glu Tyr Gly Met Ser Glu Arg Ser Leu Leu Leu Ala Tyr
                565                 570                 575     
Tyr Ile Ala Ala Ala Ser Ile Phe Glu Pro Glu Arg Ala Leu Glu Arg
            580                 585                 590         
Leu Ala Trp Ala Lys Thr Ala Ile Leu Met Glu Thr Ile Glu Thr Ile
        595                 600                 605             
Leu Lys Asp Asn Ser Ser Gln Glu Ser Gly Asn Val Leu Ser Ser Met
    610                 615                 620                 
Asn Pro Asn Leu Met Ala Ala Ala Cys Met Gln Thr Glu Gln Val Ala
625                 630                 635                 640 
Gly Ile Thr Lys Gln Glu Arg Leu Thr Glu Thr Leu Val Arg Ala Ser
                645                 650                 655     
Lys Pro Leu Leu Ile Gly Thr Arg Cys Trp His Thr Ala Gly Thr Ser
            660                 665                 670         
Ile Ser Asn Cys Ile Met Gly Arg Lys Ser Gly Leu Arg Thr Cys Glu
        675                 680                 685             
Glu Arg Asp Val His Ser Gly Gln Gly Asp Ala Glu Leu Leu Val Arg
    690                 695                 700                 
Thr Leu Asn Leu Cys Gly Gly Gly Gly Arg Trp Val Ser Glu Glu Leu
705                 710                 715                 720 
Leu Leu Ser His Pro Lys Tyr Gln His Leu Leu Glu Val Thr Asn Arg
                725                 730                 735     
Val Cys His Gln Leu Arg Leu Phe Gln Arg Arg Gln Ala Cys Asp Val
            740                 745                 750         
Asn Gly Gly Cys Met Thr Asp Val Gly Gly Ile Leu Ser Ala Gln Ile
        755                 760                 765             
Glu Ser Asn Met Gln Glu Leu Ala Lys Leu Val Pro Thr Lys Ser Ser
    770                 775                 780                 
Ser Gly Asp Leu Asp Ser Asp Thr Lys Gln Asn Phe Leu Thr Val Ala
785                 790                 795                 800 
Arg Ser Phe Tyr Tyr Ala Val Tyr Cys Asn Pro Gly Ser Ile Asn Phe
                805                 810                 815     
His Ile Ala Lys Val Leu Phe Glu Arg Val Leu
            820                 825         


<210> 490
<211> 544
<212> PRT
<213> Solanum habrochaites

<220> 
<223> sesquiterpene synthase 1 Acc. No. AAG41891

<400> 490
Met Ala Ala Ser Ser Ala Asn Lys Ser Arg Pro Leu Ala Asn Phe His
 1               5                  10                  15      
Pro Thr Val Trp Gly Tyr His Phe Leu Ser Tyr Thr His Glu Ile Thr
            20                  25                  30          
Asn Gln Glu Lys Val Glu Val Asp Glu Tyr Lys Glu Thr Ile Arg Lys
        35                  40                  45              
Met Leu Val Glu Ala Pro Glu Gly Ser Glu Gln Lys Leu Val Leu Ile
    50                  55                  60                  
Asp Ala Met Gln Arg Leu Gly Val Ala Tyr His Phe His Asn Glu Ile
65                  70                  75                  80  
Glu Thr Ser Ile Gln Asn Ile Phe Asp Ala Pro Lys Gln Asn Asn Asn
                85                  90                  95      
Leu His Ile Val Ser Leu Arg Phe Arg Leu Val Arg Gln Gln Gly His
            100                 105                 110         
Tyr Met Ser Ser Asp Val Phe Lys Gln Phe Thr Asn Gln Asp Gly Lys
        115                 120                 125             
Phe Lys Glu Thr Leu Thr Asn Asp Val Gln Gly Leu Leu Ser Leu Tyr
    130                 135                 140                 
Glu Ala Ser Tyr Leu Arg Val Arg Asp Glu Glu Ile Leu Glu Glu Ala
145                 150                 155                 160 
Leu Ala Phe Thr Thr Thr His Leu Lys Ser Ile Val Ser Thr Met Ser
                165                 170                 175     
Asn Asn Asn Asn Ser Leu Lys Val Glu Val Ser Glu Ala Leu Thr Gln
            180                 185                 190         
Pro Ile Arg Met Thr Leu Pro Arg Met Glu Ala Arg Arg Tyr Ile Ser
        195                 200                 205             
Ile Tyr Glu Asn Asn Asp Ala His Asn His Leu Leu Leu Lys Phe Ala
    210                 215                 220                 
Lys Leu Asp Phe Asn Met Leu Gln Lys Leu His Gln Arg Glu Leu Ser
225                 230                 235                 240 
Asp Leu Thr Arg Trp Trp Lys Asp Leu Asp Phe Ala Asn Lys Tyr Pro
                245                 250                 255     
Tyr Ala Arg Asp Arg Leu Val Glu Cys Tyr Phe Trp Ile Leu Gly Val
            260                 265                 270         
Tyr Phe Glu Pro Lys Tyr Ser Arg Ala Arg Lys Met Met Thr Lys Val
        275                 280                 285             
Leu Lys Met Thr Ser Ile Ile Asp Asp Thr Phe Asp Ala Tyr Ala Thr
    290                 295                 300                 
Phe Asp Glu Leu Glu Pro Phe Asn Asp Ala Ile Gln Arg Trp Asp Ala
305                 310                 315                 320 
Asn Ala Ile Asp Ser Ile Pro Pro Tyr Met Arg Pro Ala Tyr Gln Ala
                325                 330                 335     
Phe Leu Asp Ile Tyr Ser Glu Met Glu Gln Val Leu Ser Lys Lys Gly
            340                 345                 350         
Lys Leu Asp Arg Val Tyr Tyr Ala Lys Asn Glu Met Lys Lys Leu Val
        355                 360                 365             
Arg Ala Tyr Phe Lys Glu Thr Gln Trp Leu Asn Asp Cys Asp His Ile
    370                 375                 380                 
Pro Lys Tyr Glu Glu His Met Glu Asn Ser Leu Val Ser Gly Gly Tyr
385                 390                 395                 400 
Met Met Ile Pro Thr Thr Cys Leu Val Gly Met Glu Glu Phe Ile Ser
                405                 410                 415     
Ile Glu Thr Phe Glu Trp Leu Met Asn Asp Pro Leu Ile Val Arg Ala
            420                 425                 430         
Ser Ser Leu Ile Ala Arg Ala Met Asn Asp Ile Val Gly His Glu Val
        435                 440                 445             
Glu Gln Glu Arg Gly His Val Ala Ser Leu Ile Glu Cys Tyr Met Lys
    450                 455                 460                 
Asp Tyr Gly Ala Ser Lys Gln Glu Ala Tyr Ala Lys Phe Lys Lys Asp
465                 470                 475                 480 
Val Thr Asn Ala Trp Lys Asp Ile Asn Lys Glu Phe Phe Arg Pro Thr
                485                 490                 495     
Glu Val Pro Met Phe Val Leu Glu Arg Val Leu Asn Leu Thr Arg Ala
            500                 505                 510         
Ala Glu Pro Leu Tyr Lys Glu Lys Asp Ala Tyr Thr Asn Ala Lys Gly
        515                 520                 525             
Lys Leu Lys Asn Met Ile Asn Ser Ile Leu Ile Glu Ser Val Lys Ile
    530                 535                 540                 


<210> 491
<211> 546
<212> PRT
<213> Solanum habrochaites

<220> 
<223> sesquiterpene synthase 2 Acc. No. AAG41892

<400> 491
Met Ala Ala Ser Phe Ala Asn Lys Cys Arg Pro Leu Ala Asn Phe His
 1               5                  10                  15      
Pro Thr Val Trp Gly Tyr His Phe Leu Tyr Tyr Asn Pro Glu Ile Thr
            20                  25                  30          
Asn Gln Glu Lys Ile Glu Val Asp Glu Tyr Lys Glu Thr Ile Arg Lys
        35                  40                  45              
Met Leu Val Glu Ala Pro Glu Gly Ser Glu Gln Lys Leu Val Leu Ile
    50                  55                  60                  
Asp Ala Met Gln Arg Leu Gly Val Ala Tyr His Phe His Asn Glu Ile
65                  70                  75                  80  
Glu Thr Ser Ile Gln Asn Ile Phe Asp Ala Pro Lys Gln Asn Asn Asp
                85                  90                  95      
Asp Asn Leu His Ile Val Ser Leu Arg Phe Arg Leu Val Arg Gln Gln
            100                 105                 110         
Gly His Tyr Met Ser Ser Asp Val Phe Lys Gln Phe Thr Asn Gln Asp
        115                 120                 125             
Gly Lys Phe Lys Glu Thr Leu Thr Asn Asp Val Gln Gly Leu Leu Ser
    130                 135                 140                 
Leu Tyr Glu Ala Ser His Leu Arg Val Arg Asn Glu Glu Ile Leu Glu
145                 150                 155                 160 
Glu Ala Leu Thr Phe Thr Thr Thr His Leu Glu Ser Ile Val Ser Asn
                165                 170                 175     
Leu Ser Asn Lys Asn Asn Ser Leu Lys Val Glu Val Ser Glu Ala Leu
            180                 185                 190         
Ser Gln Pro Ile Arg Met Thr Leu Pro Arg Ile Gly Ala Arg Lys Tyr
        195                 200                 205             
Ile Ser Ile Tyr Glu Asn Asn Asp Ala His Asn His Leu Leu Leu Lys
    210                 215                 220                 
Phe Ala Lys Leu Asp Phe Asn Met Leu Gln Lys Phe His Gln Arg Glu
225                 230                 235                 240 
Leu Ser Asp Leu Thr Arg Trp Trp Lys Asp Leu Asp Phe Ala Asn Lys
                245                 250                 255     
Ile Pro Tyr Ala Arg Asp Arg Leu Val Glu Cys Tyr Phe Trp Ile Leu
            260                 265                 270         
Gly Val Tyr Phe Glu Pro Lys Tyr Ser Arg Ala Arg Lys Met Met Thr
        275                 280                 285             
Lys Val Leu Lys Met Thr Ser Ile Ile Asp Asp Thr Phe Asp Ala Tyr
    290                 295                 300                 
Ala Asn Phe Asp Glu Leu Val Pro Phe Asn Asp Ala Ile Gln Arg Trp
305                 310                 315                 320 
Asp Ala Asn Ala Ile Asp Ser Ile Pro Pro Tyr Met Arg Pro Ile Tyr
                325                 330                 335     
Gln Ala Leu Leu Asp Ile Tyr Gly Glu Met Asp Gln Val Leu Ser Lys
            340                 345                 350         
Glu Gly Lys Leu Asp Arg Val Tyr Tyr Ala Lys Tyr Glu Met Lys Lys
        355                 360                 365             
Leu Val Arg Ala Tyr Phe Lys Glu Ser Gln Trp Leu Asn Asp Asp Asn
    370                 375                 380                 
His Ile Pro Lys Tyr Glu Glu His Met Glu Asn Ala Ile Val Thr Val
385                 390                 395                 400 
Gly Tyr Met Met Gly Ala Thr Asn Cys Leu Val Gly Met Glu Glu Phe
                405                 410                 415     
Ile Ser Lys Glu Thr Phe Glu Trp Leu Met Ser Glu Pro Val Ile Val
            420                 425                 430         
Arg Ala Ser Ser Leu Ile Gly Arg Ala Met Asp Asp Ile Val Gly His
        435                 440                 445             
Glu Val Glu Gln Glu Arg Gly His Val Ala Ser Ile Ile Glu Cys Tyr
    450                 455                 460                 
Met Lys Asp Tyr Gly Ala Ser Lys Gln Glu Ala Tyr Ala Lys Phe Lys
465                 470                 475                 480 
Lys Asp Val Thr Asn Ala Trp Lys Asp Ile Asn Lys Glu Phe Phe Arg
                485                 490                 495     
Pro Thr Glu Val Pro Met Phe Val Leu Glu Arg Ala Leu Asn Phe Thr
            500                 505                 510         
Arg Val Ile Asp Thr Leu Tyr Gln Glu Glu Asp Glu Tyr Thr Asn Ala
        515                 520                 525             
Lys Gly Lys Leu Lys Asn Met Ile His Ser Ile Leu Ile Glu Ser Val
    530                 535                 540                 
Lys Ile
545     


<210> 492
<211> 548
<212> PRT
<213> Solanum lycopersicum

<220> 
<223> caryophyllene/alpha-humulene synthase Acc. No.
      D5KXD2

<400> 492
Met Ala Ser Ser Ser Ala Asn Lys Cys Arg Pro Leu Ala Asn Phe His
 1               5                  10                  15      
Pro Thr Val Trp Gly Tyr His Phe Leu Ser Tyr Thr His Glu Ile Thr
            20                  25                  30          
Asn Gln Glu Lys Val Glu Val Asp Glu Tyr Lys Glu Thr Ile Arg Lys
        35                  40                  45              
Met Leu Val Glu Ala Pro Glu Gly Ser Glu Gln Lys Leu Val Leu Ile
    50                  55                  60                  
Asp Ala Met Gln Arg Leu Gly Val Ala Tyr His Phe Asp Asn Glu Ile
65                  70                  75                  80  
Glu Thr Ser Ile Gln Asn Ile Phe Asp Ala Ser Ser Lys Gln Asn Asp
                85                  90                  95      
Asn Asp Asn Asn Leu Tyr Val Val Ser Leu Arg Phe Arg Leu Val Arg
            100                 105                 110         
Gln Gln Gly His Tyr Met Ser Ser Asp Val Phe Lys Gln Phe Ile Asn
        115                 120                 125             
Gln Asp Gly Lys Phe Lys Glu Thr Leu Thr Asn Asp Val Gln Gly Leu
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ser His Leu Arg Val Arg Asp Glu Glu Ile
145                 150                 155                 160 
Leu Glu Glu Ala Leu Thr Phe Thr Thr Thr His Leu Glu Ser Thr Val
                165                 170                 175     
Ser Asn Leu Ser Asn Asn Asn Ser Leu Lys Ala Glu Val Thr Glu Ala
            180                 185                 190         
Phe Ser Gln Pro Ile Arg Met Thr Leu Pro Arg Val Gly Ala Arg Lys
        195                 200                 205             
Tyr Ile Ser Ile Tyr Glu Asn Asn Asp Ala His Asn His Leu Leu Leu
    210                 215                 220                 
Lys Phe Ala Lys Leu Asp Phe Asn Met Leu Gln Lys Leu His Gln Arg
225                 230                 235                 240 
Glu Leu Ser Asp Leu Thr Arg Trp Trp Lys Asp Leu Asp Phe Ala Asn
                245                 250                 255     
Lys Tyr Pro Tyr Ala Arg Asp Arg Leu Val Glu Cys Tyr Phe Trp Ile
            260                 265                 270         
Leu Gly Val Tyr Phe Glu Pro Lys Tyr Ser Arg Ala Arg Lys Met Met
        275                 280                 285             
Thr Lys Val Ile Gln Met Ala Ser Phe Phe Asp Asp Thr Phe Asp Ala
    290                 295                 300                 
Tyr Ala Thr Phe Asp Glu Leu Glu Pro Phe Asn Asn Ala Ile Gln Arg
305                 310                 315                 320 
Trp Asp Ile Asn Ala Ile Asp Ser Val Pro Pro Tyr Leu Arg His Ala
                325                 330                 335     
Tyr Gln Ala Leu Leu Asp Ile Tyr Ser Glu Met Glu Gln Ala Leu Ala
            340                 345                 350         
Lys Glu Phe Lys Ser Asp Arg Val Tyr Tyr Ala Lys Tyr Glu Met Lys
        355                 360                 365             
Lys Leu Val Arg Ala Tyr Phe Lys Glu Ala Gln Trp Leu Asn Asn Asp
    370                 375                 380                 
Asn His Ile Pro Lys Tyr Glu Glu His Met Glu Asn Ala Met Val Ser
385                 390                 395                 400 
Ala Gly Tyr Met Met Gly Ala Thr Thr Cys Leu Val Gly Val Glu Glu
                405                 410                 415     
Phe Ile Ser Lys Glu Thr Phe Glu Trp Met Ile Asn Glu Pro Leu Ile
            420                 425                 430         
Val Arg Ala Ser Ser Leu Ile Ala Arg Ala Met Asp Asp Ile Val Gly
        435                 440                 445             
His Glu Val Glu Gln Gln Arg Glu His Gly Ala Ser Leu Ile Glu Cys
    450                 455                 460                 
Tyr Met Lys Asp Tyr Gly Val Ser Lys Gln Glu Ala Tyr Val Lys Phe
465                 470                 475                 480 
Gln Lys Glu Val Thr Asn Gly Trp Met Asp Ile Asn Arg Glu Phe Phe
                485                 490                 495     
Cys Pro Asp Val Glu Val Pro Lys Phe Val Leu Glu Arg Val Leu Asn
            500                 505                 510         
Phe Thr Arg Val Ile Asn Thr Leu Tyr Lys Glu Lys Asp Glu Tyr Thr
        515                 520                 525             
Asn Ser Lys Gly Lys Phe Lys Asn Met Ile Ile Ser Leu Leu Val Glu
    530                 535                 540                 
Ser Val Glu Ile
545             


<210> 493
<211> 800
<212> PRT
<213> Solanum lycopersicum

<220> 
<223> copalyl diphosphate synthase Acc. No. BAA84918

<400> 493
Met Ser Ile Ser Ala Ser Phe Leu Arg Phe Ser Leu Thr Ala His Tyr
 1               5                  10                  15      
Gln Pro Ser Pro Ser Ser Ser Pro Pro Asn Gln Pro Phe Lys Phe Leu
            20                  25                  30          
Lys Ser Asn Arg Glu His Val Glu Phe Asn Arg Ile Leu Gln Cys His
        35                  40                  45              
Ala Val Ser Arg Arg Arg Thr Lys Asp Tyr Lys Glu Val Gln Ser Gly
    50                  55                  60                  
Ser Leu Pro Val Ile Lys Trp Asp Asp Ile Ala Glu Glu Val Asp Glu
65                  70                  75                  80  
Glu Thr His Thr Leu Glu Val Tyr Asp Pro Ser Ser Asn Glu Asp His
                85                  90                  95      
Ile Asp Ala Ile Arg Ser Met Leu Gly Ser Met Gly Asp Gly Glu Ile
            100                 105                 110         
Ser Val Ser Ala Tyr Asp Thr Ala Trp Val Ala Met Val Lys Asp Val
        115                 120                 125             
Lys Gly Thr Glu Thr Pro Gln Phe Pro Ser Ser Leu Glu Trp Ile Ala
    130                 135                 140                 
Asn Asn Gln Leu Ala Asp Gly Ser Trp Gly Asp Asn Ser Ile Phe Leu
145                 150                 155                 160 
Val Tyr Asp Arg Val Ile Asn Thr Leu Ala Cys Val Ile Ala Leu Lys
                165                 170                 175     
Ser Trp Asn Leu His Pro Asp Lys Ile Leu Leu Gly Met Ser Phe Met
            180                 185                 190         
Arg Glu Asn Leu Ser Arg Ile Gly Asp Glu Asn Ala Glu His Met Pro
        195                 200                 205             
Ile Gly Phe Glu Val Ala Phe Pro Ser Leu Ile Glu Ile Ala Lys Lys
    210                 215                 220                 
Leu Gly Leu Asp Phe Pro Tyr Asp Ser Pro Val Leu Gln Asp Ile Tyr
225                 230                 235                 240 
Ala Ser Arg Gln Leu Lys Leu Thr Arg Ile Pro Lys Asp Ile Met His
                245                 250                 255     
Lys Val Pro Thr Thr Leu Leu His Ser Leu Glu Gly Met Thr Asp Leu
            260                 265                 270         
Asp Trp Gln Lys Leu Leu Gln Phe Gln Cys Thr Asp Gly Ser Phe Leu
        275                 280                 285             
Phe Ser Pro Ser Ser Thr Ala Tyr Ala Leu Met Gln Thr Gln Asp His
    290                 295                 300                 
Asn Cys Leu Asn Tyr Leu Lys Asn Ala Val His Lys Phe Asn Gly Gly
305                 310                 315                 320 
Val Pro Asn Val Tyr Pro Val Asp Leu Phe Glu His Ile Trp Thr Val
                325                 330                 335     
Asp Arg Leu Gln Arg Leu Gly Ile Ser Arg Tyr Phe Glu Leu Lys Ile
            340                 345                 350         
Lys Lys Cys Ile Asp Tyr Phe Ser Lys Tyr Trp Thr Asn Lys Gly Ile
        355                 360                 365             
Cys Trp Ala Arg Asn Ser Pro Val Gln Asp Ile Asp Asp Thr Ala Met
    370                 375                 380                 
Ala Phe Arg Leu Leu Arg Leu His Gly Tyr Ala Val Ser Ala Asp Val
385                 390                 395                 400 
Phe Lys His Phe Glu Ser Lys Gly Glu Phe Phe Cys Phe Val Gly Gln
                405                 410                 415     
Ser Asn Gln Ala Val Thr Gly Met Tyr Asn Leu Tyr Arg Ala Ser His
            420                 425                 430         
Val Met Phe Ser Gly Glu Lys Ile Leu Glu Asn Ala Lys Ile Ser Thr
        435                 440                 445             
Ser Asn Tyr Leu Arg Glu Lys Arg Ala Gln Asn Gln Leu Leu Asp Lys
    450                 455                 460                 
Trp Ile Ile Thr Lys Asp Leu Pro Gly Glu Val Gly Tyr Ala Leu Asp
465                 470                 475                 480 
Val Pro Trp Tyr Ala Ser Leu Pro Arg Leu Glu Thr Arg Phe Phe Leu
                485                 490                 495     
Glu His Tyr Gly Gly Glu Asp Asp Val Trp Ile Gly Lys Thr Leu Tyr
            500                 505                 510         
Arg Met Pro Leu Val Asn Asn Ser Leu Tyr Leu Glu Leu Ala Lys Ser
        515                 520                 525             
Asp Tyr Asn Asn Cys Gln Ala Leu His Gln Phe Glu Trp Arg Arg Ile
    530                 535                 540                 
Arg Lys Trp Tyr Tyr Glu Cys Gly Leu Arg Glu Phe Gly Leu Ser Glu
545                 550                 555                 560 
Lys Arg Leu Leu Val Thr Tyr Tyr Leu Gly Ser Ala Ser Ile Phe Glu
                565                 570                 575     
Ala Gln Arg Ser Thr Glu Arg Met Ala Trp Val Lys Thr Ala Ala Leu
            580                 585                 590         
Met Asp Cys Val Arg Ser Cys Phe Gly Ser Pro Gln Val Ser Ala Ala
        595                 600                 605             
Ala Phe Leu Cys Glu Phe Ala His Tyr Ser Ser Thr Ala Leu Asn Ser
    610                 615                 620                 
Arg Tyr Asn Thr Glu Asp Arg Leu Val Gly Val Ile Leu Gly Thr Leu
625                 630                 635                 640 
Asn His Leu Ser Leu Ser Ala Leu Leu Thr His Gly Arg Asp Ile His
                645                 650                 655     
His Tyr Leu Arg His Ala Trp Glu Asn Trp Leu Leu Thr Val Gly Glu
            660                 665                 670         
Gly Glu Gly Glu Gly Glu Gly Gly Ala Glu Leu Ile Ile Arg Thr Leu
        675                 680                 685             
Asn Leu Cys Ser Val His Trp Ile Ser Glu Glu Ile Leu Leu Ser His
    690                 695                 700                 
Pro Thr Tyr Gln Lys Leu Leu Glu Ile Thr Asn Arg Val Ser His Arg
705                 710                 715                 720 
Leu Arg Leu Tyr Lys Gly His Ser Glu Lys Gln Val Gly Met Leu Thr
                725                 730                 735     
Phe Ser Glu Glu Ile Glu Gly Asp Met Gln Gln Leu Ala Glu Leu Val
            740                 745                 750         
Leu Ser His Ser Asp Ala Ser Glu Leu Asp Ala Asn Ile Lys Asp Thr
        755                 760                 765             
Phe Leu Thr Val Ala Lys Ser Phe Tyr Tyr Ser Ala Tyr Cys Asp Asp
    770                 775                 780                 
Arg Thr Ile Asn Phe His Ile Ala Lys Val Leu Phe Glu Arg Val Val
785                 790                 795                 800 


<210> 494
<211> 548
<212> PRT
<213> Solanum lycopersicum

<220> 
<223> germacrene C synthase Acc. No. AAC39432

<400> 494
Met Ala Ala Ser Ser Ala Asp Lys Cys Arg Pro Leu Ala Asn Phe His
 1               5                  10                  15      
Pro Ser Val Trp Gly Tyr His Phe Leu Ser Tyr Thr His Glu Ile Thr
            20                  25                  30          
Asn Gln Glu Lys Val Glu Val Asp Glu Tyr Lys Glu Thr Ile Arg Lys
        35                  40                  45              
Met Leu Val Glu Thr Cys Asp Asn Ser Thr Gln Lys Leu Val Leu Ile
    50                  55                  60                  
Asp Ala Met Gln Arg Leu Gly Val Ala Tyr His Phe Asp Asn Glu Ile
65                  70                  75                  80  
Glu Thr Ser Ile Gln Asn Ile Phe Asp Ala Ser Ser Lys Gln Asn Asp
                85                  90                  95      
Asn Asp Asn Asn Leu Tyr Val Val Ser Leu Arg Phe Arg Leu Val Arg
            100                 105                 110         
Gln Gln Gly His Tyr Met Ser Ser Asp Val Phe Lys Gln Phe Thr Asn
        115                 120                 125             
Gln Asp Gly Lys Phe Lys Glu Thr Leu Thr Asn Asp Val Gln Gly Leu
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ser His Leu Arg Val Arg Asn Glu Glu Ile
145                 150                 155                 160 
Leu Glu Glu Ala Leu Thr Phe Thr Thr Thr His Leu Glu Ser Ile Val
                165                 170                 175     
Ser Asn Leu Ser Asn Asn Asn Asn Ser Leu Lys Val Glu Val Gly Glu
            180                 185                 190         
Ala Leu Thr Gln Pro Ile Arg Met Thr Leu Pro Arg Met Gly Ala Arg
        195                 200                 205             
Lys Tyr Ile Ser Ile Tyr Glu Asn Asn Asp Ala His His His Leu Leu
    210                 215                 220                 
Leu Lys Phe Ala Lys Leu Asp Phe Asn Met Leu Gln Lys Phe His Gln
225                 230                 235                 240 
Arg Glu Leu Ser Asp Leu Thr Arg Trp Trp Lys Asp Leu Asp Phe Ala
                245                 250                 255     
Asn Lys Tyr Pro Tyr Ala Arg Asp Arg Leu Val Glu Cys Tyr Phe Trp
            260                 265                 270         
Ile Leu Gly Val Tyr Phe Glu Pro Lys Tyr Ser Arg Ala Arg Lys Met
        275                 280                 285             
Met Thr Lys Val Leu Asn Leu Thr Ser Ile Ile Asp Asp Thr Phe Asp
    290                 295                 300                 
Ala Tyr Ala Thr Phe Asp Glu Leu Val Thr Phe Asn Asp Ala Ile Gln
305                 310                 315                 320 
Arg Trp Asp Ala Asn Ala Ile Asp Ser Ile Gln Pro Tyr Met Arg Pro
                325                 330                 335     
Ala Tyr Gln Ala Leu Leu Asp Ile Tyr Ser Glu Met Glu Gln Val Leu
            340                 345                 350         
Ser Lys Glu Gly Lys Leu Asp Arg Val Tyr Tyr Ala Lys Asn Glu Met
        355                 360                 365             
Lys Lys Leu Val Arg Ala Tyr Phe Lys Glu Thr Gln Trp Leu Asn Asp
    370                 375                 380                 
Cys Asp His Ile Pro Lys Tyr Glu Glu Gln Val Glu Asn Ala Ile Val
385                 390                 395                 400 
Ser Ala Gly Tyr Met Met Ile Ser Thr Thr Cys Leu Val Gly Ile Glu
                405                 410                 415     
Glu Phe Ile Ser His Glu Thr Phe Glu Trp Leu Met Asn Glu Ser Val
            420                 425                 430         
Ile Val Arg Ala Ser Ala Leu Ile Ala Arg Ala Met Asn Asp Ile Val
        435                 440                 445             
Gly His Glu Asp Glu Gln Glu Arg Gly His Val Ala Ser Leu Ile Glu
    450                 455                 460                 
Cys Tyr Met Lys Asp Tyr Gly Ala Ser Lys Gln Glu Thr Tyr Ile Lys
465                 470                 475                 480 
Phe Leu Lys Glu Val Thr Asn Ala Trp Lys Asp Ile Asn Lys Gln Phe
                485                 490                 495     
Ser Arg Pro Thr Glu Val Pro Met Phe Val Leu Glu Arg Val Leu Asn
            500                 505                 510         
Leu Thr Arg Val Ala Asp Thr Leu Tyr Lys Glu Lys Asp Thr Tyr Ser
        515                 520                 525             
Thr Ala Lys Gly Lys Leu Lys Asn Met Ile Asn Pro Ile Leu Ile Glu
    530                 535                 540                 
Ser Val Lys Ile
545             


<210> 495
<211> 556
<212> PRT
<213> Solanum lycopersicum

<220> 
<223> vetispiradiene synthase Acc. No. AAG09949

<400> 495
Met Ala Ser Ala Ala Ala Leu Val Ser Asn Tyr Arg Glu Glu Glu Ile
 1               5                  10                  15      
Val Arg Pro Val Ala Asp Phe Ser Pro Ser Leu Trp Gly Asp Arg Phe
            20                  25                  30          
His Ser Phe Ser Leu Asp Asn Lys Ile Ala Gly Lys Tyr Ala Gln Glu
        35                  40                  45              
Ile Glu Thr Leu Lys Glu Gln Ser Arg Val Ile Leu Ser Ala Ser Ser
    50                  55                  60                  
Gly Thr Thr Leu Ala Gln Lys Leu Asp Leu Ile Asp Ile Val Glu Arg
65                  70                  75                  80  
Leu Gly Leu Ala Tyr His Phe Glu Lys Gln Ile Asp Asp Val Leu Asp
                85                  90                  95      
Gln Ile Tyr Lys Ala Asp Pro Asn Ser Glu Ala Gln Glu Tyr Asn Asp
            100                 105                 110         
Leu Gln Thr Ser Ser Ile Gln Phe Arg Leu Leu Arg Gln His Gly Tyr
        115                 120                 125             
Asn Ile Ser Pro Lys Leu Phe Ser Arg Phe Gln Asp Ala Lys Gly Lys
    130                 135                 140                 
Phe Asn Glu Ser Leu Ser Asn Asp Ile Lys Gly Leu Leu Asn Leu Tyr
145                 150                 155                 160 
Glu Ala Ser His Val Arg Thr His Gly Glu Asp Ile Leu Glu Glu Ala
                165                 170                 175     
Leu Ala Phe Ser Thr Ala His Leu Glu Ser Ala Ala Pro His Leu Lys
            180                 185                 190         
Ser Pro Leu Ser Lys Gln Val Thr His Ala Leu Glu Gln Ser Leu His
        195                 200                 205             
Lys Ser Ile Pro Arg Val Glu Thr Arg Tyr Phe Ile Ser Ile Tyr Glu
    210                 215                 220                 
Glu Glu Glu Gln Lys Asn Asp Leu Leu Leu Arg Phe Ala Lys Leu Asp
225                 230                 235                 240 
Phe Asn Leu Leu Gln Met Leu His Lys Gln Glu Leu Ser Glu Val Ser
                245                 250                 255     
Arg Trp Trp Lys Asp Leu Asp Phe Val Thr Thr Leu Pro Tyr Ala Arg
            260                 265                 270         
Asp Arg Ala Val Glu Cys Tyr Phe Trp Thr Met Gly Val Tyr Ala Glu
        275                 280                 285             
Pro Gln Tyr Ser Gln Ala Arg Val Met Leu Ala Lys Thr Ile Ala Met
    290                 295                 300                 
Ile Ser Ile Val Asp Asp Thr Phe Asp Ala Tyr Gly Ile Val Lys Glu
305                 310                 315                 320 
Leu Glu Val Tyr Thr Asp Ala Ile Gln Arg Trp Asp Ile Ser His Ile
                325                 330                 335     
Asp Arg Leu Pro Asp Tyr Met Lys Ile Ser Tyr Lys Ala Leu Leu Asp
            340                 345                 350         
Leu Tyr Asp Asp Tyr Glu Thr Glu Leu Ser Lys Asp Gly Arg Ser Asp
        355                 360                 365             
Val Val His Tyr Ala Lys Glu Arg Met Lys Glu Ile Val Arg Asn Tyr
    370                 375                 380                 
Phe Val Glu Ala Lys Trp Phe Ile Glu Gly Tyr Met Pro Pro Val Ser
385                 390                 395                 400 
Glu Tyr Leu Cys Asn Ala Leu Ala Thr Ser Thr Tyr Tyr Leu Leu Thr
                405                 410                 415     
Thr Thr Ser Tyr Leu Gly Val Lys Ser Ala Asn Lys Glu Asp Phe Glu
            420                 425                 430         
Trp Leu Ala Lys Asn Pro Lys Ile Leu Glu Ala Asn Val Thr Leu Cys
        435                 440                 445             
Arg Val Ile Asp Asp Ile Ala Thr Tyr Asp Val Glu Lys Gly Arg Gly
    450                 455                 460                 
Gln Ile Ala Thr Gly Ile Glu Cys Tyr Met Arg Asp Tyr Gly Val Ser
465                 470                 475                 480 
Thr Glu Glu Ala Met Glu Lys Phe Glu Glu Met Ala Glu Ile Ala Trp
                485                 490                 495     
Lys Asp Val Asn Glu Gly Ile Leu Arg Pro Thr Pro Val Ser Thr Glu
            500                 505                 510         
Ile Leu Thr Arg Ile Leu Asn Leu Ala Arg Ile Ile Asp Val Thr Tyr
        515                 520                 525             
Lys His Asn Gln Asp Gly Tyr Arg His Pro Glu Lys Val Leu Lys Pro
    530                 535                 540                 
His Ile Ile Ala Leu Leu Val Asp Ser Ile Glu Ile
545                 550                 555     


<210> 496
<211> 556
<212> PRT
<213> Solanum tuberosum

<220> 
<223> putative vetispiradiene synthase 4 Acc. No.
      AAD02269

<400> 496
Met Ala Leu Ala Ala Ala Val Met Ser Asn Tyr Gly Glu Glu Glu Ile
 1               5                  10                  15      
Val Arg Pro Val Ala Asp Phe Ser Pro Ser Leu Trp Gly Asp Arg Phe
            20                  25                  30          
His Tyr Phe Ser Leu Asp Asn Gln Val Glu Lys Glu Tyr Ala Gln Glu
        35                  40                  45              
Ile Glu Thr Leu Lys Glu Gln Thr Arg Ser Met Leu Leu Ala Ala Ser
    50                  55                  60                  
Gly Met Thr Leu Ala Glu Lys Leu Asn Leu Ile Asp Ile Val Glu Arg
65                  70                  75                  80  
Leu Gly Leu Ala Tyr His Phe Glu Lys Gln Ile Glu Asp Met Leu Asp
                85                  90                  95      
Gln Ile Tyr Lys Ala His Pro Asn Phe Glu Ser His Glu Tyr Ser Asp
            100                 105                 110         
Leu Thr Thr Leu Ser Val Gln Phe Arg Leu Leu Arg Gln His Gly Tyr
        115                 120                 125             
Asn Ile Ser Pro Lys Ile Phe Ser Arg Tyr Gln Asp Ala Lys Gly Lys
    130                 135                 140                 
Phe Asn Glu Pro Leu Ser Asn Asp Ile Lys Gly Leu Leu Asn Leu Tyr
145                 150                 155                 160 
Glu Ala Ser His Val Arg Thr His Gly Glu Asp Ile Leu Glu Glu Ala
                165                 170                 175     
Leu Ala Phe Ser Thr Ala His Leu Glu Ser Ala Ala Pro His Leu Lys
            180                 185                 190         
Ser Pro Leu Ser Lys Gln Val Thr His Ala Leu Glu Gln Ser Leu His
        195                 200                 205             
Lys Ser Ile Pro Arg Val Glu Thr Arg Tyr Phe Ile Ser Ile Tyr Glu
    210                 215                 220                 
Glu Glu Glu His Lys Asn Asp Val Leu Leu Arg Phe Ala Lys Leu Asp
225                 230                 235                 240 
Phe Asn Leu Leu Gln Met Leu His Lys Gln Glu Leu Ser Glu Val Ser
                245                 250                 255     
Arg Trp Trp Lys Asp Leu Asp Phe Val Thr Thr Leu Pro Tyr Ala Arg
            260                 265                 270         
Asp Arg Ala Val Glu Cys Tyr Phe Trp Thr Met Gly Val Tyr Ala Glu
        275                 280                 285             
Pro Gln Tyr Ser Gln Ala Arg Val Met Leu Ala Lys Thr Ile Ala Met
    290                 295                 300                 
Ile Ser Ile Val Asp Asp Thr Phe Asp Ala Tyr Gly Ile Val Lys Glu
305                 310                 315                 320 
Leu Glu Val Tyr Thr Asp Ala Ile Gln Arg Trp Asp Ile Ser Gln Ile
                325                 330                 335     
Asp Arg Leu Pro Asp Tyr Met Lys Ile Ser Tyr Lys Ala Leu Leu Asp
            340                 345                 350         
Leu Tyr Asn Asp Tyr Glu Thr Glu Leu Ser Met Asp Gly Arg Ser Asp
        355                 360                 365             
Val Val His Tyr Ala Lys Glu Arg Met Lys Glu Ile Val Arg Asn Tyr
    370                 375                 380                 
Phe Val Glu Ala Lys Trp Phe Ile Glu Gly Tyr Met Pro Pro Val Ser
385                 390                 395                 400 
Glu Tyr Leu Ser Asn Ala Leu Ala Thr Ser Thr Tyr Tyr Leu Leu Thr
                405                 410                 415     
Thr Thr Ser Tyr Leu Gly Val Lys Ser Ala Asn Lys Glu Asp Phe Glu
            420                 425                 430         
Trp Leu Ala Lys Asn Pro Lys Ile Leu Glu Ala Asn Val Thr Leu Cys
        435                 440                 445             
Arg Val Ile Asp Asp Ile Ala Thr Tyr Glu Val Glu Lys Gly Arg Gly
    450                 455                 460                 
Gln Ile Ala Thr Gly Ile Glu Cys Tyr Met Arg Asp Tyr Gly Val Ser
465                 470                 475                 480 
Thr Glu Val Ala Met Glu Lys Phe Gln Glu Met Ala Glu Ile Ala Trp
                485                 490                 495     
Lys Asp Val Asn Glu Gly Ile Leu Arg Pro Thr Pro Ile Ser Thr Glu
            500                 505                 510         
Ile Leu Thr Arg Ile Leu Asn Leu Ala Arg Ile Ile Asp Val Thr Tyr
        515                 520                 525             
Lys His Asn Gln Asp Gly Tyr Thr His Pro Glu Lys Val Leu Lys Pro
    530                 535                 540                 
His Ile Ile Ala Leu Leu Val Asp Ser Ile Glu Ile
545                 550                 555     


<210> 497
<211> 556
<212> PRT
<213> Solanum tuberosum

<220> 
<223> vetispiradiene synthase Acc. No. BAA82092

<400> 497
Met Thr Pro Ala Ala Val Val Met Ser Asn Tyr Gly Glu Glu Glu Ile
 1               5                  10                  15      
Val Arg Pro Ile Ala Asp Phe Ser Pro Ser Leu Trp Gly Asp Arg Phe
            20                  25                  30          
His Ser Phe Ser Leu Asp Asn Gln Ile Ala Gly Lys Tyr Ala Gln Glu
        35                  40                  45              
Ile Glu Thr Leu Lys Glu Gln Ser Arg Ile Ile Leu Ser Ala Ser Ser
    50                  55                  60                  
Arg Arg Thr Leu Ala Glu Lys Leu Asp Leu Ile Asp Ile Val Glu Arg
65                  70                  75                  80  
Leu Gly Ile Ala Tyr His Phe Glu Lys Gln Ile Asp Asp Met Leu Asp
                85                  90                  95      
Gln Phe Tyr Lys Ala Asp Pro Asn Phe Glu Ala His Glu Tyr Asn Asp
            100                 105                 110         
Leu Gln Thr Leu Ser Val Gln Phe Arg Leu Leu Arg Gln His Gly Tyr
        115                 120                 125             
Asn Ile Ser Pro Lys Leu Phe Ile Arg Phe Gln Asp Ala Lys Gly Lys
    130                 135                 140                 
Phe Lys Glu Ser Leu Cys Asn Asp Ile Lys Gly Leu Leu Asn Leu Tyr
145                 150                 155                 160 
Glu Ala Ser His Val Arg Thr His Gly Glu Asp Ile Leu Glu Glu Ala
                165                 170                 175     
Leu Ala Phe Ser Thr Ala His Leu Glu Ser Ala Ala Pro His Leu Lys
            180                 185                 190         
Ser Pro Leu Ser Lys Gln Val Thr His Ala Leu Glu Gln Ser Leu His
        195                 200                 205             
Lys Ser Ile Pro Arg Val Glu Thr Arg Tyr Phe Ile Ser Ile Tyr Glu
    210                 215                 220                 
Glu Glu Glu Gln Lys Asn Asp Val Leu Leu Gln Phe Ala Lys Leu Asp
225                 230                 235                 240 
Phe Asn Leu Leu Gln Met Leu His Lys Gln Glu Leu Ser Glu Val Ser
                245                 250                 255     
Arg Trp Trp Lys Asp Leu Asp Phe Val Thr Thr Leu Pro Tyr Ala Arg
            260                 265                 270         
Asp Arg Ala Val Glu Cys Tyr Phe Trp Thr Met Gly Val Tyr Ala Glu
        275                 280                 285             
Pro Gln Tyr Ser Gln Ala Arg Val Met Leu Ala Lys Thr Ile Ala Met
    290                 295                 300                 
Ile Ser Ile Val Asp Asp Thr Phe Asp Ala Tyr Gly Ile Val Lys Glu
305                 310                 315                 320 
Leu Glu Ile Tyr Thr Asp Ala Ile Gln Arg Trp Asp Ile Ser Gln Ile
                325                 330                 335     
Asp Arg Leu Pro Asp Tyr Met Lys Ile Ser Tyr Lys Ala Leu Leu Asp
            340                 345                 350         
Leu Tyr Asn Asp Tyr Glu Met Glu Leu Ser Lys Asp Gly Arg Ser Asp
        355                 360                 365             
Val Val His Tyr Ala Lys Glu Arg Met Lys Glu Ile Val Arg Asn Tyr
    370                 375                 380                 
Phe Val Glu Ala Lys Trp Phe Ile Glu Gly Tyr Met Pro Pro Val Ser
385                 390                 395                 400 
Glu Tyr Leu Ser Asn Ala Leu Ala Thr Ser Thr Tyr Tyr Leu Leu Thr
                405                 410                 415     
Thr Thr Ser Tyr Leu Gly Met Lys Ser Ala Asn Lys Gln Asp Phe Glu
            420                 425                 430         
Trp Leu Ala Lys Asn Pro Lys Ile Leu Glu Ala Asn Val Thr Leu Cys
        435                 440                 445             
Arg Val Ile Asp Asp Ile Ala Thr Tyr Glu Val Glu Lys Gly Arg Gly
    450                 455                 460                 
Gln Ile Ala Thr Gly Ile Glu Cys Tyr Met Arg Asp Tyr Gly Val Ser
465                 470                 475                 480 
Thr Glu Lys Ala Met Glu Lys Phe Gln Glu Met Ala Glu Thr Ala Trp
                485                 490                 495     
Lys Asp Val Asn Glu Gly Ile Leu Arg Pro Thr Pro Val Ser Thr Glu
            500                 505                 510         
Ile Leu Thr Arg Ile Leu Asn Leu Ala Arg Ile Ile Asp Val Thr Tyr
        515                 520                 525             
Lys His Asn Gln Asp Gly Tyr Thr His Pro Glu Lys Val Leu Lys Pro
    530                 535                 540                 
His Ile Ile Ala Leu Leu Val Asp Ser Ile Glu Ile
545                 550                 555     


<210> 498
<211> 549
<212> PRT
<213> Solidago canadensis

<220> 
<223> germacrene A synthase Acc. No. CAC36896

<400> 498
Met Ala Ala Lys Gln Val Glu Val Ile Arg Pro Val Ala Asn Tyr His
 1               5                  10                  15      
Pro Ser Leu Trp Gly Asp Gln Phe Leu His Tyr Asp Glu Gln Glu Asp
            20                  25                  30          
Glu His Val Glu Val Asp Gln Gln Ile Glu Ile Leu Lys Glu Glu Thr
        35                  40                  45              
Arg Lys Glu Ile Leu Ala Ser Leu Asp Asp Pro Thr Lys His Thr Asn
    50                  55                  60                  
Leu Leu Lys Leu Ile Asp Val Ile Gln Arg Leu Gly Ile Ala Tyr Tyr
65                  70                  75                  80  
Phe Glu His Glu Ile Thr Gln Ala Leu Asp His Ile Tyr Ser Val Tyr
                85                  90                  95      
Gly Asp Glu Trp Asn Gly Gly Arg Thr Ser Leu Trp Phe Arg Leu Leu
            100                 105                 110         
Arg Gln Gln Gly Phe Tyr Val Ser Cys Asp Ile Phe Asn Ile Tyr Lys
        115                 120                 125             
Leu Asp Asn Gly Ser Phe Lys Asp Ser Leu Thr Lys Asp Ile Glu Cys
    130                 135                 140                 
Met Leu Glu Leu Tyr Glu Ala Ala Tyr Met Arg Val Gln Gly Glu Ile
145                 150                 155                 160 
Ile Leu Asp Glu Ala Leu Glu Phe Thr Lys Thr His Leu Glu His Ile
                165                 170                 175     
Ala Lys Asp Pro Leu Arg Cys Asn Asn Thr Leu Ser Arg His Ile His
            180                 185                 190         
Glu Ala Leu Glu Arg Pro Val Gln Lys Arg Leu Pro Arg Leu Asp Ala
        195                 200                 205             
Ile Arg Tyr Ile Pro Phe Tyr Glu Gln Gln Asp Ser His Asn Lys Ser
    210                 215                 220                 
Leu Leu Arg Leu Ala Lys Leu Gly Phe Asn Arg Leu Gln Ser Leu His
225                 230                 235                 240 
Lys Lys Glu Leu Ser Gln Leu Ser Lys Trp Trp Lys Glu Phe Asp Ala
                245                 250                 255     
Pro Lys Asn Leu Pro Tyr Val Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Ile Leu Gly Val Tyr Phe Glu Pro Gln Tyr Ser Arg Ser Arg Ile
        275                 280                 285             
Phe Leu Thr Lys Thr Ile Lys Met Ala Ala Ile Leu Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ile Tyr Gly Thr Tyr Glu Glu Leu Glu Ile Phe Thr Lys Ala Val
305                 310                 315                 320 
Gln Arg Trp Ser Ile Thr Cys Met Asp Thr Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Val Ile Tyr Lys Ser Leu Leu Asp Val Tyr Glu Glu Met Glu Glu Ile
            340                 345                 350         
Ile Glu Lys Asp Gly Lys Ala Tyr Gln Val His Tyr Ala Lys Glu Ser
        355                 360                 365             
Met Ile Asp Leu Val Thr Ser Tyr Met Thr Glu Ala Lys Trp Leu His
    370                 375                 380                 
Glu Gly His Val Pro Thr Phe Asp Glu His Asn Ser Val Thr Asn Ile
385                 390                 395                 400 
Thr Gly Gly Tyr Lys Met Leu Thr Ala Ser Ser Phe Val Gly Met His
                405                 410                 415     
Gly Asp Ile Val Thr Gln Glu Ser Phe Lys Trp Val Leu Asn Asn Pro
            420                 425                 430         
Pro Leu Ile Lys Ala Ser Ser Asp Ile Ser Arg Ile Met Asn Asp Ile
        435                 440                 445             
Val Gly His Lys Glu Glu Gln Gln Arg Lys His Ile Ala Ser Ser Val
    450                 455                 460                 
Glu Met Tyr Met Lys Glu Tyr Asn Leu Ala Glu Glu Asp Val Tyr Asp
465                 470                 475                 480 
Phe Leu Lys Glu Arg Val Glu Asp Ala Trp Lys Asp Ile Asn Arg Glu
                485                 490                 495     
Thr Leu Thr Cys Lys Asp Ile His Met Ala Leu Lys Met Pro Pro Ile
            500                 505                 510         
Asn Leu Ala Arg Val Met Asp Met Leu Tyr Lys Asn Gly Asp Asn Leu
        515                 520                 525             
Lys Asn Val Gly Gln Glu Ile Gln Asp Tyr Met Lys Ser Cys Phe Ile
    530                 535                 540                 
Asn Pro Met Ser Val
545                 


<210> 499
<211> 551
<212> PRT
<213> Solidago canadensis

<220> 
<223> germacrene D synthase Acc. No. CAE47440

<400> 499
Met Ala Ala Lys Gln Gly Glu Val Val Arg Pro Asp Ala Asp Tyr Ser
 1               5                  10                  15      
Tyr His Pro Ser Leu Trp Gly Asp Gln Phe Leu His Tyr Asp Glu Gln
            20                  25                  30          
Glu Asp Asp Gln Val Glu Val Asp Gln Gln Ile Glu Ile Leu Lys Glu
        35                  40                  45              
Glu Thr Arg Arg Glu Ile Leu Ser Ser Leu Asp Asp Pro Ala Lys His
    50                  55                  60                  
Thr Asn Leu Leu Lys Leu Ile Asp Val Ile Gln Arg Leu Gly Ile Ala
65                  70                  75                  80  
Tyr Tyr Phe Glu His Glu Ile Thr Gln Ala Leu Asp His Ile Tyr Asn
                85                  90                  95      
Val Tyr Gly Asp Glu Trp Asn Gly Gly Ser Thr Ser Leu Trp Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Phe Tyr Val Ser Cys Asp Ile Phe Asn Ile
        115                 120                 125             
Tyr Lys Leu Asp Asn Gly Ser Phe Lys Asp Ser Leu Thr Lys Asp Ile
    130                 135                 140                 
Glu Cys Met Leu Glu Leu Tyr Glu Ala Ala Tyr Met Arg Val Gln Gly
145                 150                 155                 160 
Glu Ile Ile Leu Asp Glu Ala Leu Glu Phe Thr Lys Thr His Leu Glu
                165                 170                 175     
Gln Ile Ala Lys Asp Pro Leu Arg Cys Asn Asn Thr Leu Ser Arg His
            180                 185                 190         
Ile Tyr Glu Ala Leu Lys Arg Pro Ile Arg Lys Arg Leu Pro Arg Val
        195                 200                 205             
Asp Ala Leu Gln Tyr Met Pro Phe Tyr Glu Gln Gln Asp Ser His Asn
    210                 215                 220                 
Lys Ser Leu Leu Arg Leu Ala Lys Leu Gly Phe Asn Arg Leu Gln Ser
225                 230                 235                 240 
Leu His Lys Lys Glu Leu Ser Gln Leu Ser Lys Trp Trp Lys Glu Phe
                245                 250                 255     
Asp Ala Pro Lys Asn Leu Arg Tyr Val Arg Asp Arg Leu Val Glu Leu
            260                 265                 270         
Tyr Phe Trp Val Leu Gly Val Tyr Phe Glu Pro Gln Tyr Ser Arg Ser
        275                 280                 285             
Arg Ile Phe Leu Thr Lys Val Ile Lys Met Ala Thr Ile Leu Asp Asp
    290                 295                 300                 
Thr Tyr Asp Ile His Gly Thr Tyr Glu Glu Leu Glu Ile Phe Thr Lys
305                 310                 315                 320 
Ala Val Gln Arg Trp Ser Ile Thr Cys Met Asp Thr Leu Pro Asp Tyr
                325                 330                 335     
Met Lys Met Ile Tyr Lys Ser Leu Leu Asp Val Tyr Glu Glu Met Glu
            340                 345                 350         
Glu Ile Ile Glu Lys Asp Gly Lys Ala Tyr Gln Val His Tyr Ala Lys
        355                 360                 365             
Asp Ser Met Ile Asp Leu Val Thr Ser Tyr Met Thr Glu Ala Lys Trp
    370                 375                 380                 
Leu His Glu Gly His Val Pro Thr Phe Glu Glu Tyr Asn Ser Ile Thr
385                 390                 395                 400 
Asn Leu Thr Gly Gly Tyr Lys Met Leu Thr Thr Ser Ser Phe Val Asp
                405                 410                 415     
Met Pro Gly Asp Ile Val Thr Gln Glu Ser Phe Arg Trp Ala Leu Asn
            420                 425                 430         
Asn Pro Pro Leu Ile Lys Ala Ser Ala Asp Val Ser Arg Ile Met Asp
        435                 440                 445             
Asp Ile Val Gly His Lys Glu Glu Gln Gln Arg Lys His Leu Pro Ser
    450                 455                 460                 
Arg Val Glu Met Tyr Met Lys Lys Tyr His Leu Ala Glu Glu Asp Val
465                 470                 475                 480 
Tyr Asp Leu Leu Lys Gln Arg Val Glu Asp Ala Trp Lys Asp Leu Asn
                485                 490                 495     
Arg Glu Thr Leu Thr Cys Lys Asp Ile His Met Ala Leu Lys Met Arg
            500                 505                 510         
Pro Ile Asn Leu Ala Arg Val Ile Asp Met Leu Tyr Lys Asn Asp Asp
        515                 520                 525             
Asn Leu Lys Asn Val Gly Gln Glu Ile Gln Asp Tyr Ile Lys Ser Cys
    530                 535                 540                 
Phe Ile Asn Ala Ile Ser Val
545                 550     


<210> 500
<211> 787
<212> PRT
<213> Stevia rebaudiana

<220> 
<223> (-)-copalyl diphosphate synthase Acc. No. AAB87091

<400> 500
Met Lys Thr Gly Phe Ile Ser Pro Ala Thr Val Phe His His Arg Ile
 1               5                  10                  15      
Ser Pro Ala Thr Thr Phe Arg His His Leu Ser Pro Ala Thr Thr Asn
            20                  25                  30          
Ser Thr Gly Ile Val Ala Leu Arg Asp Ile Asn Phe Arg Cys Lys Ala
        35                  40                  45              
Val Ser Lys Glu Tyr Ser Asp Leu Leu Gln Lys Asp Glu Ala Ser Phe
    50                  55                  60                  
Thr Lys Trp Asp Asp Asp Lys Val Lys Asp His Leu Asp Thr Asn Lys
65                  70                  75                  80  
Asn Leu Tyr Pro Asn Asp Glu Ile Lys Glu Phe Val Glu Ser Val Lys
                85                  90                  95      
Ala Met Phe Gly Ser Met Asn Asp Gly Glu Ile Asn Val Ser Ala Tyr
            100                 105                 110         
Asp Thr Ala Trp Val Ala Leu Val Gln Asp Val Asp Gly Ser Gly Ser
        115                 120                 125             
Pro Gln Phe Pro Ser Ser Leu Glu Trp Ile Ala Asn Asn Gln Leu Ser
    130                 135                 140                 
Asp Gly Ser Trp Gly Asp His Leu Leu Phe Ser Ala His Asp Arg Ile
145                 150                 155                 160 
Ile Asn Thr Leu Ala Cys Val Ile Ala Leu Thr Ser Trp Asn Val His
                165                 170                 175     
Pro Ser Lys Cys Glu Lys Gly Leu Asn Phe Leu Arg Glu Asn Ile Cys
            180                 185                 190         
Lys Leu Glu Asp Glu Asn Ala Glu His Met Pro Ile Gly Phe Glu Val
        195                 200                 205             
Thr Phe Pro Ser Leu Ile Asp Ile Ala Lys Lys Leu Asn Ile Glu Val
    210                 215                 220                 
Pro Glu Asp Thr Pro Ala Leu Lys Glu Ile Tyr Ala Arg Arg Asp Ile
225                 230                 235                 240 
Lys Leu Thr Lys Ile Pro Met Glu Val Leu His Lys Val Pro Thr Thr
                245                 250                 255     
Leu Leu His Ser Leu Glu Gly Met Pro Asp Leu Glu Trp Glu Lys Leu
            260                 265                 270         
Leu Lys Leu Gln Cys Lys Asp Gly Ser Phe Leu Phe Ser Pro Ser Ser
        275                 280                 285             
Thr Ala Phe Ala Leu Met Gln Thr Lys Asp Glu Lys Cys Leu Gln Tyr
    290                 295                 300                 
Leu Thr Asn Ile Val Thr Lys Phe Asn Gly Gly Val Pro Asn Val Tyr
305                 310                 315                 320 
Pro Val Asp Leu Phe Glu His Ile Trp Val Val Asp Arg Leu Gln Arg
                325                 330                 335     
Leu Gly Ile Ala Arg Tyr Phe Lys Ser Glu Ile Lys Asp Cys Val Glu
            340                 345                 350         
Tyr Ile Asn Lys Tyr Trp Thr Lys Asn Gly Ile Cys Trp Ala Arg Asn
        355                 360                 365             
Thr His Val Gln Asp Ile Asp Asp Thr Ala Met Gly Phe Arg Val Leu
    370                 375                 380                 
Arg Ala His Gly Tyr Asp Val Thr Pro Asp Val Phe Arg Gln Phe Glu
385                 390                 395                 400 
Lys Asp Gly Lys Phe Val Cys Phe Ala Gly Gln Ser Thr Gln Ala Val
                405                 410                 415     
Thr Gly Met Phe Asn Val Tyr Arg Ala Ser Gln Met Leu Phe Pro Gly
            420                 425                 430         
Glu Arg Ile Leu Glu Asp Ala Lys Lys Phe Ser Tyr Asn Tyr Leu Lys
        435                 440                 445             
Glu Lys Gln Ser Thr Asn Glu Leu Leu Asp Lys Trp Ile Ile Ala Lys
    450                 455                 460                 
Asp Leu Pro Gly Glu Val Gly Tyr Ala Leu Asp Ile Pro Trp Tyr Ala
465                 470                 475                 480 
Ser Leu Pro Arg Leu Glu Thr Arg Tyr Tyr Leu Glu Gln Tyr Gly Gly
                485                 490                 495     
Glu Asp Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met Gly Tyr Val
            500                 505                 510         
Ser Asn Asn Thr Tyr Leu Glu Met Ala Lys Leu Asp Tyr Asn Asn Tyr
        515                 520                 525             
Val Ala Val Leu Gln Leu Glu Trp Tyr Thr Ile Gln Gln Trp Tyr Val
    530                 535                 540                 
Asp Ile Gly Ile Glu Lys Phe Glu Ser Asp Asn Ile Lys Ser Val Leu
545                 550                 555                 560 
Val Ser Tyr Tyr Leu Ala Ala Ala Ser Ile Phe Glu Pro Glu Arg Ser
                565                 570                 575     
Lys Glu Arg Ile Ala Trp Ala Lys Thr Thr Ile Leu Val Asp Lys Ile
            580                 585                 590         
Thr Ser Ile Phe Asp Ser Ser Gln Ser Ser Lys Glu Asp Ile Thr Ala
        595                 600                 605             
Phe Ile Asp Lys Phe Arg Asn Lys Ser Ser Ser Lys Lys His Ser Ile
    610                 615                 620                 
Asn Gly Glu Pro Trp His Glu Val Met Val Ala Leu Lys Lys Thr Leu
625                 630                 635                 640 
His Gly Phe Ala Leu Asp Ala Leu Met Thr His Ser Gln Asp Ile His
                645                 650                 655     
Pro Gln Leu His Gln Ala Trp Glu Met Trp Leu Thr Lys Leu Gln Asp
            660                 665                 670         
Gly Val Asp Val Thr Ala Glu Leu Met Val Gln Met Ile Asn Met Thr
        675                 680                 685             
Ala Gly Arg Trp Val Ser Lys Glu Leu Leu Thr His Pro Gln Tyr Gln
    690                 695                 700                 
Arg Leu Ser Thr Val Thr Asn Ser Val Cys His Asp Ile Thr Lys Leu
705                 710                 715                 720 
His Asn Phe Lys Glu Asn Ser Thr Thr Val Asp Ser Lys Val Gln Glu
                725                 730                 735     
Leu Val Gln Leu Val Phe Ser Asp Thr Pro Asp Asp Leu Asp Gln Asp
            740                 745                 750         
Met Lys Gln Thr Phe Leu Thr Val Met Lys Thr Phe Tyr Tyr Lys Ala
        755                 760                 765             
Trp Cys Asp Pro Asn Thr Ile Asn Asp His Ile Ser Lys Val Phe Glu
    770                 775                 780                 
Ile Val Ile
785         


<210> 501
<211> 784
<212> PRT
<213> Stevia rebaudiana

<220> 
<223> (-)-ent-kaurene synthase Acc. No. AAD34295

<400> 501
Met Asn Leu Ser Leu Cys Ile Ala Ser Pro Leu Leu Thr Lys Ser Asn
 1               5                  10                  15      
Arg Pro Ala Ala Leu Ser Ala Ile His Thr Ala Ser Thr Ser His Gly
            20                  25                  30          
Gly Gln Thr Asn Pro Thr Asn Leu Ile Ile Asp Thr Thr Lys Glu Arg
        35                  40                  45              
Ile Gln Lys Gln Phe Lys Asn Val Glu Ile Ser Val Ser Ser Tyr Asp
    50                  55                  60                  
Thr Ala Trp Val Ala Met Val Pro Ser Pro Asn Ser Pro Lys Ser Pro
65                  70                  75                  80  
Cys Phe Pro Glu Cys Leu Asn Trp Leu Ile Asn Asn Gln Leu Asn Asp
                85                  90                  95      
Gly Ser Trp Gly Leu Val Asn His Thr His Asn His Asn His Pro Leu
            100                 105                 110         
Leu Lys Asp Ser Leu Ser Ser Thr Leu Ala Cys Ile Val Ala Leu Lys
        115                 120                 125             
Arg Trp Asn Val Gly Glu Asp Gln Ile Asn Lys Gly Leu Ser Phe Ile
    130                 135                 140                 
Glu Ser Asn Leu Ala Ser Ala Thr Glu Lys Ser Gln Pro Ser Pro Ile
145                 150                 155                 160 
Gly Phe Asp Ile Ile Phe Pro Gly Leu Leu Glu Tyr Ala Lys Asn Leu
                165                 170                 175     
Asp Ile Asn Leu Leu Ser Lys Gln Thr Asp Phe Ser Leu Met Leu His
            180                 185                 190         
Lys Arg Glu Leu Glu Gln Lys Arg Cys His Ser Asn Glu Met Asp Gly
        195                 200                 205             
Tyr Leu Ala Tyr Ile Ser Glu Gly Leu Gly Asn Leu Tyr Asp Trp Asn
    210                 215                 220                 
Met Val Lys Lys Tyr Gln Met Lys Asn Gly Ser Val Phe Asn Ser Pro
225                 230                 235                 240 
Ser Ala Thr Ala Ala Ala Phe Ile Asn His Gln Asn Pro Gly Cys Leu
                245                 250                 255     
Asn Tyr Leu Asn Ser Leu Leu Asp Lys Phe Gly Asn Ala Val Pro Thr
            260                 265                 270         
Val Tyr Pro His Asp Leu Phe Ile Arg Leu Ser Met Val Asp Thr Ile
        275                 280                 285             
Glu Arg Leu Gly Ile Ser His His Phe Arg Val Glu Ile Lys Asn Val
    290                 295                 300                 
Leu Asp Glu Thr Tyr Arg Cys Trp Val Glu Arg Asp Glu Gln Ile Phe
305                 310                 315                 320 
Met Asp Val Val Thr Cys Ala Leu Ala Phe Arg Leu Leu Arg Ile Asn
                325                 330                 335     
Gly Tyr Glu Val Ser Pro Asp Pro Leu Ala Glu Ile Thr Asn Glu Leu
            340                 345                 350         
Ala Leu Lys Asp Glu Tyr Ala Ala Leu Glu Thr Tyr His Ala Ser His
        355                 360                 365             
Ile Leu Tyr Gln Glu Asp Leu Ser Ser Gly Lys Gln Ile Leu Lys Ser
    370                 375                 380                 
Ala Asp Phe Leu Lys Glu Ile Ile Ser Thr Asp Ser Asn Arg Leu Ser
385                 390                 395                 400 
Lys Leu Ile His Lys Glu Val Glu Asn Ala Leu Lys Phe Pro Ile Asn
                405                 410                 415     
Thr Gly Leu Glu Arg Ile Asn Thr Arg Arg Asn Ile Gln Leu Tyr Asn
            420                 425                 430         
Val Asp Asn Thr Arg Ile Leu Lys Thr Thr Tyr His Ser Ser Asn Ile
        435                 440                 445             
Ser Asn Thr Asp Tyr Leu Arg Leu Ala Val Glu Asp Phe Tyr Thr Cys
    450                 455                 460                 
Gln Ser Ile Tyr Arg Glu Glu Leu Lys Gly Leu Glu Arg Trp Val Val
465                 470                 475                 480 
Glu Asn Lys Leu Asp Gln Leu Lys Phe Ala Arg Gln Lys Thr Ala Tyr
                485                 490                 495     
Cys Tyr Phe Ser Val Ala Ala Thr Leu Ser Ser Pro Glu Leu Ser Asp
            500                 505                 510         
Ala Arg Ile Ser Trp Ala Lys Asn Gly Ile Leu Thr Thr Val Val Asp
        515                 520                 525             
Asp Phe Phe Asp Ile Gly Gly Thr Ile Asp Glu Leu Thr Asn Leu Ile
    530                 535                 540                 
Gln Cys Val Glu Lys Trp Asn Val Asp Val Asp Lys Asp Cys Cys Ser
545                 550                 555                 560 
Glu His Val Arg Ile Leu Phe Leu Ala Leu Lys Asp Ala Ile Cys Trp
                565                 570                 575     
Ile Gly Asp Glu Ala Phe Lys Trp Gln Ala Arg Asp Val Thr Ser His
            580                 585                 590         
Val Ile Gln Thr Trp Leu Glu Leu Met Asn Ser Met Leu Arg Glu Ala
        595                 600                 605             
Ile Trp Thr Arg Asp Ala Tyr Val Pro Thr Leu Asn Glu Tyr Met Glu
    610                 615                 620                 
Asn Ala Tyr Val Ser Phe Ala Leu Gly Pro Ile Val Lys Pro Ala Ile
625                 630                 635                 640 
Tyr Phe Val Gly Pro Lys Leu Ser Glu Glu Ile Val Glu Ser Ser Glu
                645                 650                 655     
Tyr His Asn Leu Phe Lys Leu Met Ser Thr Gln Gly Arg Leu Leu Asn
            660                 665                 670         
Asp Ile His Ser Phe Lys Arg Glu Phe Lys Glu Gly Lys Leu Asn Ala
        675                 680                 685             
Val Ala Leu His Leu Ser Asn Gly Glu Ser Gly Lys Val Glu Glu Glu
    690                 695                 700                 
Val Val Glu Glu Met Met Met Met Ile Lys Asn Lys Arg Lys Glu Leu
705                 710                 715                 720 
Met Lys Leu Ile Phe Glu Glu Asn Gly Ser Ile Val Pro Arg Ala Cys
                725                 730                 735     
Lys Asp Ala Phe Trp Asn Met Cys His Val Leu Asn Phe Phe Tyr Ala
            740                 745                 750         
Asn Asp Asp Gly Phe Thr Gly Asn Thr Ile Leu Asp Thr Val Lys Asp
        755                 760                 765             
Ile Ile Tyr Asn Pro Leu Val Leu Val Asn Glu Asn Glu Glu Gln Arg
    770                 775                 780                 


<210> 502
<211> 784
<212> PRT
<213> Stevia rebaudiana

<220> 
<223> kaurene synthase Acc. No. AAD34294

<400> 502
Met Asn Leu Ser Leu Cys Ile Ala Ser Pro Leu Leu Thr Lys Ser Ser
 1               5                  10                  15      
Arg Pro Thr Ala Leu Ser Ala Ile His Thr Ala Ser Thr Ser His Gly
            20                  25                  30          
Gly Gln Thr Asn Pro Thr Asn Leu Ile Ile Asp Thr Thr Lys Glu Arg
        35                  40                  45              
Ile Gln Lys Leu Phe Lys Asn Val Glu Ile Ser Val Ser Ser Tyr Asp
    50                  55                  60                  
Thr Ala Trp Val Ala Met Val Pro Ser Pro Asn Ser Pro Lys Ser Pro
65                  70                  75                  80  
Cys Phe Pro Glu Cys Leu Asn Trp Leu Ile Asn Asn Gln Leu Asn Asp
                85                  90                  95      
Gly Ser Trp Gly Leu Val Asn His Thr His Asn His Asn His Pro Leu
            100                 105                 110         
Leu Lys Asp Ser Leu Ser Ser Thr Leu Ala Cys Ile Val Ala Leu Lys
        115                 120                 125             
Arg Trp Asn Val Gly Glu Asp Gln Ile Asn Lys Gly Leu Ser Phe Ile
    130                 135                 140                 
Glu Ser Asn Leu Ala Ser Ala Thr Asp Lys Ser Gln Pro Ser Pro Ile
145                 150                 155                 160 
Gly Phe Asp Ile Ile Phe Pro Gly Leu Leu Glu Tyr Ala Lys Asn Leu
                165                 170                 175     
Asp Ile Asn Leu Leu Ser Lys Gln Thr Asp Phe Ser Leu Met Leu His
            180                 185                 190         
Lys Arg Glu Leu Glu Gln Lys Arg Cys His Ser Asn Glu Ile Asp Gly
        195                 200                 205             
Tyr Leu Ala Tyr Ile Ser Glu Gly Leu Gly Asn Leu Tyr Asp Trp Asn
    210                 215                 220                 
Met Val Lys Lys Tyr Gln Met Lys Asn Gly Ser Val Phe Asn Ser Pro
225                 230                 235                 240 
Ser Ala Thr Ala Ala Ala Phe Ile Asn His Gln Asn Pro Gly Cys Leu
                245                 250                 255     
Asn Tyr Leu Asn Ser Leu Leu Asp Lys Phe Gly Asn Ala Val Pro Thr
            260                 265                 270         
Val Tyr Pro Leu Asp Leu Tyr Ile Arg Leu Ser Met Val Asp Thr Ile
        275                 280                 285             
Glu Arg Leu Gly Ile Ser His His Phe Arg Val Glu Ile Lys Asn Val
    290                 295                 300                 
Leu Asp Glu Thr Tyr Arg Cys Trp Val Glu Arg Asp Glu Gln Ile Phe
305                 310                 315                 320 
Met Asp Val Val Thr Cys Ala Leu Ala Phe Arg Leu Leu Arg Ile His
                325                 330                 335     
Gly Tyr Lys Val Ser Pro Asp Gln Leu Ala Glu Ile Thr Asn Glu Leu
            340                 345                 350         
Ala Phe Lys Asp Glu Tyr Ala Ala Leu Glu Thr Tyr His Ala Ser Gln
        355                 360                 365             
Ile Leu Tyr Gln Glu Asp Leu Ser Ser Gly Lys Gln Ile Leu Lys Ser
    370                 375                 380                 
Ala Asp Phe Leu Lys Gly Ile Leu Ser Thr Asp Ser Asn Arg Leu Ser
385                 390                 395                 400 
Lys Leu Ile His Lys Glu Val Glu Asn Ala Leu Lys Phe Pro Ile Asn
                405                 410                 415     
Thr Gly Leu Glu Arg Ile Asn Thr Arg Arg Asn Ile Gln Leu Tyr Asn
            420                 425                 430         
Val Asp Asn Thr Arg Ile Leu Lys Thr Thr Tyr His Ser Ser Asn Ile
        435                 440                 445             
Ser Asn Thr Tyr Tyr Leu Arg Leu Ala Val Glu Asp Phe Tyr Thr Cys
    450                 455                 460                 
Gln Ser Ile Tyr Arg Glu Glu Leu Lys Gly Leu Glu Arg Trp Val Val
465                 470                 475                 480 
Gln Asn Lys Leu Asp Gln Leu Lys Phe Ala Arg Gln Lys Thr Ala Tyr
                485                 490                 495     
Cys Tyr Phe Ser Val Ala Ala Thr Leu Ser Ser Pro Glu Leu Ser Asp
            500                 505                 510         
Ala Arg Ile Ser Trp Ala Lys Asn Gly Ile Leu Thr Thr Val Val Asp
        515                 520                 525             
Asp Phe Phe Asp Ile Gly Gly Thr Ile Asp Glu Leu Thr Asn Leu Ile
    530                 535                 540                 
Gln Cys Val Glu Lys Trp Asn Val Asp Val Asp Lys Asp Cys Cys Ser
545                 550                 555                 560 
Glu His Val Arg Ile Leu Phe Leu Ala Leu Lys Asp Ala Ile Cys Trp
                565                 570                 575     
Ile Gly Asp Glu Ala Phe Lys Trp Gln Ala Arg Asp Val Thr Ser His
            580                 585                 590         
Val Ile Gln Thr Trp Leu Glu Leu Met Asn Ser Met Leu Arg Glu Ala
        595                 600                 605             
Ile Trp Thr Arg Asp Ala Tyr Val Pro Thr Leu Asn Glu Tyr Met Glu
    610                 615                 620                 
Asn Ala Tyr Val Ser Phe Ala Leu Gly Pro Ile Val Lys Pro Ala Ile
625                 630                 635                 640 
Tyr Phe Val Gly Pro Lys Leu Ser Glu Glu Ile Val Glu Ser Ser Glu
                645                 650                 655     
Tyr His Asn Leu Phe Lys Leu Met Ser Thr Gln Gly Arg Leu Leu Asn
            660                 665                 670         
Asp Ile His Ser Phe Lys Arg Glu Phe Lys Glu Gly Lys Leu Asn Ala
        675                 680                 685             
Val Ala Leu His Leu Ser Asn Gly Glu Ser Gly Lys Val Glu Glu Glu
    690                 695                 700                 
Val Val Glu Glu Met Met Met Met Ile Lys Asn Lys Arg Lys Glu Leu
705                 710                 715                 720 
Met Lys Leu Ile Phe Glu Glu Asn Gly Ser Ile Val Pro Arg Ala Cys
                725                 730                 735     
Lys Asp Ala Phe Trp Asn Met Cys His Val Leu Asn Phe Phe Tyr Ala
            740                 745                 750         
Asn Asp Asp Gly Phe Thr Gly Asn Thr Ile Leu Asp Thr Val Lys Asp
        755                 760                 765             
Ile Ile Tyr Asn Pro Leu Val Leu Val Asn Glu Asn Glu Glu Gln Arg
    770                 775                 780                 


<210> 503
<211> 862
<212> PRT
<213> Taxus wallilchiana

<220> 
<223> var. chinensis taxadiene synthase Acc. No. Q9FT37

<400> 503
Met Ala Gln Leu Ser Phe Asn Ala Ala Leu Lys Met Asn Ala Leu Gly
 1               5                  10                  15      
Asn Lys Ala Ile His Asp Pro Thr Asn Cys Arg Ala Lys Ser Glu Gly
            20                  25                  30          
Gln Met Met Trp Val Cys Ser Lys Ser Gly Arg Thr Arg Val Lys Met
        35                  40                  45              
Ser Arg Gly Ser Gly Gly Pro Gly Pro Val Val Met Met Ser Ser Ser
    50                  55                  60                  
Thr Gly Thr Ser Lys Val Val Ser Glu Thr Ser Ser Thr Ile Val Asp
65                  70                  75                  80  
Asp Ile Pro Arg Leu Ser Ala Asn Tyr His Gly Asp Leu Trp His His
                85                  90                  95      
Asn Val Ile Gln Thr Leu Glu Thr Pro Phe Arg Glu Ser Ser Thr Tyr
            100                 105                 110         
Gln Glu Arg Ala Asp Glu Leu Val Val Lys Ile Lys Asp Met Phe Asn
        115                 120                 125             
Ala Leu Gly Asp Gly Asp Ile Ser Pro Ser Ala Tyr Asp Thr Ala Trp
    130                 135                 140                 
Val Ala Arg Val Ala Thr Ile Ser Ser Asp Gly Ser Glu Lys Pro Arg
145                 150                 155                 160 
Phe Pro Gln Ala Leu Asn Trp Val Phe Asn Asn Gln Leu Gln Asp Gly
                165                 170                 175     
Ser Trp Gly Ile Glu Ser His Phe Ser Leu Cys Asp Arg Leu Leu Asn
            180                 185                 190         
Thr Thr Asn Ser Val Ile Ala Leu Ser Val Trp Lys Thr Gly His Ser
        195                 200                 205             
Gln Val Glu Gln Gly Thr Glu Phe Ile Ala Glu Asn Leu Arg Leu Leu
    210                 215                 220                 
Asn Glu Glu Asp Glu Leu Ser Pro Asp Phe Glu Ile Ile Phe Pro Ala
225                 230                 235                 240 
Leu Leu Gln Lys Ala Lys Ala Leu Gly Ile Asn Leu Pro Tyr Asp Leu
                245                 250                 255     
Pro Phe Ile Lys Tyr Leu Ser Thr Thr Arg Glu Ala Arg Leu Thr Asp
            260                 265                 270         
Val Ser Ala Ala Ala Asp Asn Ile Pro Ala Asn Met Leu Asn Ala Leu
        275                 280                 285             
Glu Gly Leu Glu Glu Val Met Asp Trp Lys Lys Ile Met Arg Phe Gln
    290                 295                 300                 
Ser Lys Asp Gly Ser Phe Leu Ser Ser Pro Ala Ser Thr Ala Cys Val
305                 310                 315                 320 
Leu Met Asn Thr Gly Asp Glu Lys Cys Phe Thr Phe Leu Asn Asn Leu
                325                 330                 335     
Leu Val Lys Phe Gly Gly Cys Val Pro Cys Met Tyr Ser Ile Asp Leu
            340                 345                 350         
Leu Glu Arg Leu Ser Leu Val Asp Asn Ile Glu His Leu Gly Ile Gly
        355                 360                 365             
Arg His Phe Lys Gln Glu Ile Lys Val Ala Leu Asp Tyr Val Tyr Arg
    370                 375                 380                 
His Trp Ser Glu Arg Gly Ile Gly Trp Gly Arg Asp Ser Leu Val Pro
385                 390                 395                 400 
Asp Leu Asn Thr Thr Ala Leu Gly Leu Arg Thr Leu Arg Thr His Gly
                405                 410                 415     
Tyr Asp Val Ser Ser Asp Val Leu Asn Asn Phe Lys Asp Glu Asn Gly
            420                 425                 430         
Arg Phe Phe Ser Ser Ala Gly Gln Thr His Val Glu Leu Arg Ser Val
        435                 440                 445             
Val Ile Leu Phe Arg Ala Ser Asp Leu Ala Phe Pro Asp Glu Gly Ala
    450                 455                 460                 
Met Asp Asp Ala Arg Lys Phe Ala Glu Pro Tyr Leu Arg Asp Ala Leu
465                 470                 475                 480 
Ala Thr Lys Ile Ser Thr Asn Thr Lys Leu Phe Lys Glu Ile Glu Tyr
                485                 490                 495     
Val Val Glu Tyr Pro Trp His Met Ser Ile Pro Arg Ser Glu Ala Arg
            500                 505                 510         
Ser Tyr Ile Asp Ser Tyr Asp Asp Asp Tyr Val Trp Glu Arg Lys Thr
        515                 520                 525             
Leu Tyr Arg Met Pro Ser Leu Ser Asn Ser Lys Cys Leu Glu Leu Ala
    530                 535                 540                 
Lys Leu Asp Phe Asn Ile Val Gln Ser Leu His Gln Glu Glu Leu Lys
545                 550                 555                 560 
Leu Leu Thr Arg Trp Trp Lys Glu Ser Gly Met Ala Asp Ile Asn Phe
                565                 570                 575     
Thr Arg His Arg Val Ala Glu Val Tyr Phe Ser Ser Ala Thr Phe Glu
            580                 585                 590         
Pro Glu Tyr Ser Ala Thr Arg Ile Ala Phe Thr Lys Ile Gly Cys Leu
        595                 600                 605             
Gln Val Leu Phe Asp Asp Met Ala Asp Ile Phe Ala Thr Leu Asp Glu
    610                 615                 620                 
Leu Lys Ser Phe Thr Glu Gly Val Lys Arg Trp Asp Thr Ser Leu Leu
625                 630                 635                 640 
His Glu Ile Pro Glu Cys Met Gln Thr Cys Phe Lys Val Trp Phe Lys
                645                 650                 655     
Leu Ile Glu Glu Val Asn Asn Asp Val Val Lys Val Gln Gly Arg Asp
            660                 665                 670         
Met Leu Ala His Ile Arg Lys Pro Trp Glu Leu Tyr Phe Asn Cys Tyr
        675                 680                 685             
Val Gln Glu Arg Glu Trp Leu Asp Ala Gly Tyr Ile Pro Thr Phe Glu
    690                 695                 700                 
Glu Tyr Leu Lys Thr Tyr Ala Ile Ser Val Gly Leu Gly Pro Cys Thr
705                 710                 715                 720 
Leu Gln Pro Ile Leu Leu Met Gly Glu Leu Val Lys Asp Asp Val Val
                725                 730                 735     
Glu Lys Val His Tyr Pro Ser Asn Met Phe Glu Leu Val Ser Leu Ser
            740                 745                 750         
Trp Arg Leu Thr Asn Asp Thr Lys Thr Tyr Gln Ala Glu Lys Ala Arg
        755                 760                 765             
Gly Gln Gln Ala Ser Gly Ile Ala Cys Tyr Met Lys Asp Asn Leu Gly
    770                 775                 780                 
Ala Thr Glu Glu Asp Ala Ile Lys His Ile Cys Arg Val Val Asp Arg
785                 790                 795                 800 
Ala Leu Lys Glu Ala Ser Phe Glu Tyr Phe Lys Pro Ser Asn Asp Ile
                805                 810                 815     
Pro Met Gly Cys Lys Ser Phe Ile Phe Asn Leu Arg Leu Cys Val Gln
            820                 825                 830         
Ile Phe Tyr Lys Phe Ile Asp Gly Tyr Gly Ile Ala Asn Glu Glu Ile
        835                 840                 845             
Lys Asp Tyr Ile Arg Lys Val Tyr Ile Asp Pro Ile Gln Val
    850                 855                 860         


<210> 504
<211> 557
<212> PRT
<213> Vitis vinifera

<220> 
<223> (-)-germacrene D synthase Acc. No. AAS66357

<400> 504
Met Ser Val Gln Ser Ser Gly Val Leu Leu Ala Pro Ser Lys Asn Leu
 1               5                  10                  15      
Ser Pro Glu Val Gly Arg Arg Cys Ala Asn Phe His Pro Ser Ile Trp
            20                  25                  30          
Gly Asp His Phe Leu Ser Tyr Ala Ser Glu Phe Thr Asn Thr Asp Asp
        35                  40                  45              
His Leu Lys Gln His Val Gln Gln Leu Lys Glu Glu Val Arg Lys Met
    50                  55                  60                  
Leu Met Ala Ala Asp Asp Asp Ser Ala Gln Lys Leu Leu Leu Ile Asp
65                  70                  75                  80  
Ala Ile Gln Arg Leu Gly Val Ala Tyr His Phe Glu Ser Glu Ile Asp
                85                  90                  95      
Glu Val Leu Lys His Met Phe Asp Gly Ser Val Val Ser Ala Glu Glu
            100                 105                 110         
Asp Val Tyr Thr Ala Ser Leu Arg Phe Arg Leu Leu Arg Gln Gln Gly
        115                 120                 125             
Tyr His Val Ser Cys Asp Leu Phe Asn Asn Phe Lys Asp Asn Glu Gly
    130                 135                 140                 
Asn Phe Lys Glu Ser Leu Ser Ser Asp Val Arg Gly Met Leu Ser Leu
145                 150                 155                 160 
Tyr Glu Ala Thr His Phe Arg Val His Gly Glu Asp Ile Leu Asp Glu
                165                 170                 175     
Ala Leu Ala Phe Thr Thr Thr His Leu Gln Ser Ala Thr Lys His Ser
            180                 185                 190         
Ser Asn Pro Leu Ala Glu Gln Val Val His Ala Leu Lys Gln Pro Ile
        195                 200                 205             
Arg Lys Gly Leu Pro Arg Leu Glu Ala Arg His Tyr Phe Ser Val Tyr
    210                 215                 220                 
Gln Ala Asp Asp Ser His Asn Lys Ala Leu Leu Lys Leu Ala Lys Leu
225                 230                 235                 240 
Asp Phe Asn Leu Leu Gln Lys Leu His Gln Lys Glu Leu Ser Asp Ile
                245                 250                 255     
Ser Ala Trp Trp Lys Asp Leu Asp Phe Ala His Lys Leu Pro Phe Ala
            260                 265                 270         
Arg Asp Arg Val Val Glu Cys Tyr Phe Trp Ile Leu Gly Val Tyr Phe
        275                 280                 285             
Glu Pro Gln Phe Phe Phe Ala Arg Arg Ile Leu Thr Lys Val Ile Ala
    290                 295                 300                 
Met Thr Ser Ile Ile Asp Asp Ile Tyr Asp Val Tyr Gly Thr Leu Glu
305                 310                 315                 320 
Glu Leu Glu Leu Phe Thr Glu Ala Val Glu Arg Trp Asp Ile Ser Ala
                325                 330                 335     
Ile Asp Gln Leu Pro Glu Tyr Met Arg Val Cys Tyr Gln Ala Leu Leu
            340                 345                 350         
Tyr Val Tyr Ser Glu Ile Glu Glu Glu Met Ala Lys Glu Gly Arg Ser
        355                 360                 365             
Tyr Arg Leu Tyr Tyr Ala Lys Glu Ala Met Lys Asn Gln Val Arg Ala
    370                 375                 380                 
Tyr Tyr Glu Glu Ala Lys Trp Leu Gln Val Gln Gln Ile Pro Thr Met
385                 390                 395                 400 
Glu Glu Tyr Met Pro Val Ala Leu Val Thr Ser Ala Tyr Ser Met Leu
                405                 410                 415     
Ala Thr Thr Ser Phe Val Gly Met Gly Asp Ala Val Thr Lys Glu Ser
            420                 425                 430         
Phe Asp Trp Ile Phe Ser Lys Pro Lys Ile Val Arg Ala Ser Ala Ile
        435                 440                 445             
Val Cys Arg Leu Met Asp Asp Met Val Phe His Lys Phe Glu Gln Lys
    450                 455                 460                 
Arg Gly His Val Ala Ser Ala Val Glu Cys Tyr Met Lys Gln His Gly
465                 470                 475                 480 
Ala Ser Glu Gln Glu Thr Pro Asn Glu Phe Pro Gln Pro Val Arg Glu
                485                 490                 495     
Ala Trp Lys Asp Ile Asn Glu Glu Cys Leu Ile Pro Thr Ala Val Pro
            500                 505                 510         
Met Pro Ile Leu Met Arg Val Leu Asn Leu Ala Arg Val Ile Asp Val
        515                 520                 525             
Ile Tyr Lys Asn Glu Asp Gly Tyr Thr His Phe Gly Ala Val Leu Lys
    530                 535                 540                 
Asp Phe Val Thr Ser Met Leu Ile Asp Pro Val Pro Ile
545                 550                 555         


<210> 505
<211> 547
<212> PRT
<213> Zea diploperennis

<220> 
<223> (E)-beta-caryophyllene synthase Acc. No. ABY79209

<400> 505
Met Ala Ala Asp Glu Ala Arg Ser Val Ser Arg Leu His Ser Glu Glu
 1               5                  10                  15      
Asp Met His Gly Lys His His Ser Thr Leu Trp Gly Asp Phe Phe Leu
            20                  25                  30          
His His Val Pro Cys Arg Pro Gly Gln Tyr Leu Ile Met Lys Asp Lys
        35                  40                  45              
Val Lys Ile Met Lys Glu Glu Val Lys Lys Met Leu Leu Asp Val Gly
    50                  55                  60                  
Ser Ser Asp Leu Ser His Lys Leu Asp Cys Ile Asn Thr Leu Glu Arg
65                  70                  75                  80  
Leu Gly Leu Asp Tyr His Tyr Thr Lys Glu Ile Asp Glu Leu Met Cys
                85                  90                  95      
Asn Val Phe Glu Ala Arg Asp Gln Asp Leu Asp Leu Thr Thr Thr Ser
            100                 105                 110         
Gln Leu Phe Tyr Leu Leu Arg Lys His Gly Tyr His Val Ser Ser Asp
        115                 120                 125             
Val Phe Leu Lys Phe Arg Asp Asp Lys Gly Asp Ile Val Thr Asp Asp
    130                 135                 140                 
Ala Arg Cys Leu Leu Arg Met Tyr Glu Ala Ala His Val Arg Val Asn
145                 150                 155                 160 
Gly Glu Glu Ile Leu Asp Asn Ile Leu Ile His Thr Lys Arg Gln Leu
                165                 170                 175     
Gln Cys Ile Val Asp Asp Leu Glu Pro Thr Leu Gln Glu Glu Val Arg
            180                 185                 190         
Tyr Ala Leu Glu Thr Pro Leu Phe Arg Arg Leu Asn Arg Val Gln Ala
        195                 200                 205             
Arg Gln Phe Ile Ser Thr Tyr Glu Lys Ser Thr Thr Arg Asn Asn Met
    210                 215                 220                 
Leu Leu Glu Phe Ser Lys Leu Asp Phe Asn Ile Leu Leu Thr Leu Tyr
225                 230                 235                 240 
Cys Glu Glu Leu Lys Asp Leu Thr Leu Trp Trp Lys Glu Phe Gln Ala
                245                 250                 255     
Gln Ala Asn Thr Ala Ile Tyr Ala Arg Asp Arg Met Val Glu Met His
            260                 265                 270         
Phe Trp Met Met Gly Val Phe Phe Glu Pro Gln Tyr Ser Tyr Ser Arg
        275                 280                 285             
Lys Met Leu Thr Gln Leu Phe Met Ile Val Ser Val Leu Asp Asp Leu
    290                 295                 300                 
Tyr Asp Ser His Cys Thr Thr Glu Glu Gly Asn Thr Phe Thr Ala Ala
305                 310                 315                 320 
Leu Gln Arg Trp Asp Glu Glu Gly Val Glu Gln Cys Pro Thr Tyr Leu
                325                 330                 335     
Arg Thr Leu Tyr Thr Asn Ile Arg Ala Thr Val Lys Ala Ile Glu Glu
            340                 345                 350         
Asp Leu Asn Leu Gln Asn Asn Lys His Ala Lys Leu Val Lys Gly Leu
        355                 360                 365             
Ile Ile Asp Met Ala Met Cys Tyr Asn Ala Glu Thr Glu Trp Arg Asp
    370                 375                 380                 
Lys Lys Tyr Val Pro Ala Thr Val Asp Glu His Leu Lys Ile Ser Ala
385                 390                 395                 400 
Arg Ser Ser Gly Cys Met His Leu Val Ser Gln Gly Phe Ile Ser Met
                405                 410                 415     
Gly Asp Val Ala Thr Ser Glu Ala Leu Glu Trp Ala Ser Thr Tyr Pro
            420                 425                 430         
Lys Ile Val Arg Ala Val Cys Ile Ile Ala Arg Leu Ala Asn Asp Ile
        435                 440                 445             
Met Ser Tyr Lys Arg Glu Ala Ser Asn Asn Thr Met Val Ser Thr Val
    450                 455                 460                 
Gln Thr Cys Ala Lys Glu Tyr Gly Thr Thr Thr Val Glu Gln Ala Ile
465                 470                 475                 480 
Glu Lys Ile Arg Glu Leu Ile Glu Glu Ala Trp Met Asp Ile Thr His
                485                 490                 495     
Glu Cys Leu Arg Gln Pro Gln Pro Lys Ala Leu Leu Glu Arg Ala Val
            500                 505                 510         
Asn Leu Ala Arg Thr Met Asp Phe Leu Tyr Lys Asp Val Asp Gly Tyr
        515                 520                 525             
Thr Asp Ser Arg Ser Ile Lys Gly Ile Leu Asp Ser Leu Tyr Val His
    530                 535                 540                 
Leu Ile Asp
545         


<210> 506
<211> 547
<212> PRT
<213> Zea luxurians

<220> 
<223> (E)-beta-caryophyllene synthase Acc. No. ABY79211

<400> 506
Met Ala Ala Asp Glu Ala Arg Ser Val Ser Arg Leu His Gly Glu Glu
 1               5                  10                  15      
Asp Met His Gly Lys His His Ser Thr Leu Trp Gly Asp Phe Phe Leu
            20                  25                  30          
His His Val Pro Cys Arg Pro Gly Gln Tyr Leu Ile Met Lys Asp Asn
        35                  40                  45              
Val Glu Ile Met Lys Glu Glu Val Lys Lys Met Leu Leu Asp Val Gly
    50                  55                  60                  
Ser Ser Asp Leu Ser His Lys Leu Asp Cys Ile Asp Thr Leu Gly Arg
65                  70                  75                  80  
Leu Gly Leu Asp Tyr His Tyr Thr Lys Glu Ile Asp Glu Leu Met Cys
                85                  90                  95      
Asn Val Phe Glu Ala Met Asp Gln Asp Leu Asp Leu Thr Thr Thr Ser
            100                 105                 110         
Gln Leu Phe Tyr Leu Leu Arg Lys His Gly Tyr His Ile Ser Ser Asp
        115                 120                 125             
Val Phe Leu Lys Phe Arg Asp Asp Lys Gly Asp Ile Val Thr Asn Asp
    130                 135                 140                 
Ala Arg Cys Leu Leu Arg Met Tyr Glu Ala Ala His Val Arg Val Asn
145                 150                 155                 160 
Gly Glu Glu Ile Leu Asp Asn Ile Leu Ile His Thr Lys Arg Gln Leu
                165                 170                 175     
Gln Cys Ile Val Asp Asp Leu Glu Pro Thr Leu Gln Glu Glu Val Arg
            180                 185                 190         
Tyr Ala Leu Glu Thr Pro Leu Phe Arg Arg Leu Asn Arg Val Gln Ala
        195                 200                 205             
Arg Gln Phe Ile Ser Thr Tyr Glu Lys Ser Thr Thr Arg Asn Asn Met
    210                 215                 220                 
Leu Leu Glu Phe Ser Lys Leu Asp Phe Asn Ile Leu Leu Thr Leu Tyr
225                 230                 235                 240 
Cys Glu Glu Leu Lys Asp Leu Thr Leu Trp Trp Lys Glu Phe Gln Ala
                245                 250                 255     
Gln Ala Asn Met Thr Ile Tyr Ala Arg Asp Arg Met Val Glu Met His
            260                 265                 270         
Phe Trp Met Met Gly Val Phe Phe Glu Pro Gln Tyr Ser Tyr Ser Arg
        275                 280                 285             
Lys Met Leu Thr Arg Leu Phe Met Ile Val Ser Val Leu Asp Asp Leu
    290                 295                 300                 
Tyr Asp Ser His Cys Thr Thr Glu Glu Gly Asn Ala Phe Thr Ala Ala
305                 310                 315                 320 
Leu Gln Arg Trp Asp Glu Glu Gly Val Glu Gln Cys Pro Thr Tyr Leu
                325                 330                 335     
Arg Thr Leu Tyr Thr Asn Ile Arg Ala Thr Val Lys Ala Ile Glu Glu
            340                 345                 350         
Asp Leu Asn Leu Gln Asn Asn Lys His Ala Lys Leu Val Lys Gly Leu
        355                 360                 365             
Ile Ile Asp Met Ala Met Cys Tyr Asn Ala Glu Thr Glu Trp Arg Asp
    370                 375                 380                 
Lys Lys Tyr Val Pro Ala Thr Val Asp Glu His Leu Lys Ile Ser Ala
385                 390                 395                 400 
Arg Ser Ser Gly Cys Met His Leu Val Ser Gln Gly Phe Ile Ser Met
                405                 410                 415     
Gly Asp Val Ala Thr Ser Glu Ala Leu Glu Trp Ala Ser Thr Tyr Pro
            420                 425                 430         
Lys Ile Val Arg Ala Val Cys Ile Ile Ala Arg Leu Ala Asn Asp Ile
        435                 440                 445             
Met Ser Tyr Lys Arg Glu Ala Ser Asn Asn Thr Met Val Ser Thr Val
    450                 455                 460                 
Gln Thr Cys Ala Lys Glu Tyr Gly Thr Thr Thr Val Glu Gln Ala Ile
465                 470                 475                 480 
Glu Lys Ile Arg Glu Leu Ile Glu Glu Ala Trp Met Asp Ile Thr His
                485                 490                 495     
Glu Cys Leu Arg Gln Pro Gln Pro Lys Ala Leu Leu Glu Arg Ala Val
            500                 505                 510         
Asn Leu Ala Arg Thr Met Asp Phe Leu Tyr Lys Asp Val Asp Gly Tyr
        515                 520                 525             
Thr Asp Ser Arg Ser Ile Lys Gly Ile Leu Asp Ser Leu Tyr Val His
    530                 535                 540                 
Leu Ile Asp
545         


<210> 507
<211> 547
<212> PRT
<213> Zea mays

<220> 
<223> huehuetenangensis (E)-beta-caryophyllene synthase
      Acc. No. ABY79210

<400> 507
Met Ala Ala Asp Glu Ala Arg Ser Val Ser Arg Leu His Ser Glu Glu
 1               5                  10                  15      
Asp Met His Gly Lys His His Ser Thr Leu Trp Gly Asp Phe Phe Leu
            20                  25                  30          
His His Val Pro Cys Arg Pro Gly Gln Tyr Ser Ile Met Lys Asp Asn
        35                  40                  45              
Val Lys Ile Met Lys Glu Glu Val Lys Lys Met Leu Leu Asp Val Gly
    50                  55                  60                  
Ser Ser Asp Leu Ser His Lys Leu Glu Cys Ile Asp Thr Leu Glu Arg
65                  70                  75                  80  
Leu Gly Leu Asp Tyr His Tyr Thr Lys Glu Ile Asp Glu Leu Met Cys
                85                  90                  95      
Asn Val Phe Glu Ala Arg Asp Gln Asp Leu Asp Leu Thr Thr Thr Ser
            100                 105                 110         
Gln Leu Phe Tyr Leu Leu Arg Lys His Gly Tyr His Val Ser Ser Asp
        115                 120                 125             
Val Phe Leu Lys Phe Gly Asp Asp Lys Gly Asp Ile Val Thr Asp Asp
    130                 135                 140                 
Ala Arg Cys Leu Leu Arg Met Tyr Glu Ala Ala His Val Arg Val Asn
145                 150                 155                 160 
Gly Glu Glu Ile Leu Asp Asn Ile Leu Ile His Thr Lys Arg Gln Leu
                165                 170                 175     
Gln Cys Ile Val Asp Asp Leu Glu Pro Thr Leu Gln Glu Glu Val Arg
            180                 185                 190         
Tyr Ala Leu Glu Thr Pro Leu Phe Arg Arg Leu Asn Arg Val Gln Ala
        195                 200                 205             
Arg Gln Phe Ile Ser Thr Tyr Glu Lys Ser Thr Met Arg Asn Asn Met
    210                 215                 220                 
Leu Leu Glu Phe Ser Lys Leu Asp Phe Asn Ile Leu Leu Thr Leu Tyr
225                 230                 235                 240 
Cys Glu Glu Leu Lys Asp Leu Thr Met Trp Trp Lys Glu Phe Gln Ala
                245                 250                 255     
Gln Ala Asn Thr Thr Ile Tyr Ala Arg Asp Arg Met Val Glu Met His
            260                 265                 270         
Phe Trp Met Met Gly Val Phe Phe Glu Pro Gln Tyr Ser Tyr Ser Arg
        275                 280                 285             
Lys Met Leu Thr Gln Leu Phe Met Ile Val Ser Val Leu Asp Asp Leu
    290                 295                 300                 
Tyr Asp Ser His Cys Thr Thr Glu Glu Gly Asn Ala Phe Thr Ala Ala
305                 310                 315                 320 
Leu Gln Arg Trp Asp Glu Glu Gly Val Glu Gln Cys Pro Thr Tyr Leu
                325                 330                 335     
Arg Thr Leu Tyr Thr Asn Ile Arg Ala Thr Val Lys Ala Ile Glu Glu
            340                 345                 350         
Asp Leu Asn Leu Gln Asn Asn Lys His Ala Lys Leu Val Lys Gly Leu
        355                 360                 365             
Ile Ile Asp Met Ala Met Cys Tyr Asn Ala Glu Thr Glu Trp Arg Asp
    370                 375                 380                 
Lys Lys Tyr Val Pro Ala Thr Val Asp Glu His Leu Lys Ile Ser Ala
385                 390                 395                 400 
Arg Ser Ser Gly Cys Met His Leu Val Ser Gln Gly Phe Ile Ser Met
                405                 410                 415     
Gly Asp Val Ala Thr Ser Glu Ala Leu Glu Trp Ala Ser Thr Tyr Pro
            420                 425                 430         
Lys Ile Val Arg Ala Val Cys Ile Ile Ala Arg Leu Ala Asn Asp Ile
        435                 440                 445             
Met Ser Tyr Lys Arg Glu Ala Ser Asn Asn Thr Met Val Ser Thr Val
    450                 455                 460                 
Gln Thr Cys Ala Lys Glu Tyr Gly Thr Thr Thr Val Glu Gln Ala Ile
465                 470                 475                 480 
Glu Lys Ile Arg Glu Leu Ile Glu Glu Ala Trp Met Asp Ile Thr His
                485                 490                 495     
Glu Cys Leu Arg Gln Pro Gln Pro Met Ala Leu Leu Glu Arg Ala Val
            500                 505                 510         
Asn Leu Ala Arg Thr Met Asp Phe Leu Tyr Lys Asp Val Asp Gly Tyr
        515                 520                 525             
Thr Asp Ser Trp Ser Ile Lys Gly Ile Leu Asp Ser Leu Tyr Val His
    530                 535                 540                 
Leu Ile Asp
545         


<210> 508
<211> 548
<212> PRT
<213> Zea mays

<220> 
<223> (-)-beta-macrocarpene synthase Acc. No. AAS88576

<400> 508
Met Ala Ala Pro Thr Leu Thr Ala Asp Gly Pro Arg Leu Gly Gln Gln
 1               5                  10                  15      
Glu Met Lys Lys Met Ser Pro Ser Phe His Pro Thr Leu Trp Gly Asp
            20                  25                  30          
Phe Phe Leu Ser Tyr Glu Ala Pro Thr Glu Ala Gln Glu Ala Gln Met
        35                  40                  45              
Arg Glu Lys Ala Ala Val Leu Lys Glu Glu Val Arg Asn Met Ile Lys
    50                  55                  60                  
Gly Ser His Asp Val Pro Glu Ile Val Asp Leu Ile Ile Thr Leu Gln
65                  70                  75                  80  
Arg Leu Asn Leu Asp Tyr His Tyr Glu Asp Glu Ile Asn Glu Lys Leu
                85                  90                  95      
Thr Val Val Tyr Lys Ser Asn Tyr Asp Gly Gly Asn Leu Asp Leu Val
            100                 105                 110         
Ser Arg Arg Phe Tyr Leu Leu Arg Lys Cys Gly Tyr Asp Val Ser Ser
        115                 120                 125             
Asp Val Phe Leu Lys Phe Lys Asp Gln Leu Gly Asn Phe Val Glu Ala
    130                 135                 140                 
Asp Thr Arg Ser Leu Leu Ser Leu Tyr Asn Ala Ala Phe Leu Arg Ile
145                 150                 155                 160 
His Gly Glu Thr Val Leu Asp Glu Ala Ile Ser Phe Thr Met Arg Val
                165                 170                 175     
Leu Gln Asp Arg Leu Glu His Leu Glu Ser Pro Leu Ala Glu Glu Val
            180                 185                 190         
Ser Ser Ala Leu Asp Thr Pro Leu Phe Arg Arg Val Gly Thr Leu Glu
        195                 200                 205             
Met Lys Asp Tyr Ile Pro Ile Tyr Glu Lys Asp Ala Lys Gln Asn Lys
    210                 215                 220                 
Ser Ile Leu Glu Phe Ala Lys Leu Asn Phe Asn Leu Leu Gln Leu Arg
225                 230                 235                 240 
Tyr Ser Ser Glu Leu Lys Glu Cys Thr Thr Trp Trp Lys Glu Leu Arg
                245                 250                 255     
Val Glu Ser Asn Leu Ser Phe Val Arg Asp Arg Ile Val Glu Val Tyr
            260                 265                 270         
Phe Trp Met Ser Gly Gly Cys Tyr Asp Pro Gln Tyr Ser His Ser Arg
        275                 280                 285             
Ile Ile Leu Thr Lys Ile Val Ala Phe Ile Thr Ile Leu Asp Asp Thr
    290                 295                 300                 
Leu Asp Ser His Ala Thr Ser Cys Glu Ser Met Gln Leu Ala Glu Ala
305                 310                 315                 320 
Ile Glu Arg Trp Asp Glu Ser Ala Val Ser Leu Leu Pro Glu Tyr Met
                325                 330                 335     
Lys Asp Phe Tyr Met Tyr Leu Leu Lys Thr Phe Ser Ser Phe Glu Asn
            340                 345                 350         
Glu Leu Gly Pro Asp Lys Ser Tyr Arg Val Phe Tyr Leu Lys Glu Ala
        355                 360                 365             
Val Lys Glu Leu Val Arg Glu Tyr Thr Lys Glu Ile Lys Trp Arg Asp
    370                 375                 380                 
Glu Asp Tyr Val Pro Lys Thr Leu Lys Glu His Leu Lys Val Ser Leu
385                 390                 395                 400 
Ile Ser Ile Gly Gly Thr Leu Val Leu Cys Ser Ala Phe Val Gly Met
                405                 410                 415     
Gly Asp Val Val Thr Lys Lys Ile Met Lys Trp Val Met Ser Asp Ala
            420                 425                 430         
Glu Leu Val Lys Ser Phe Gly Ile Phe Val Arg Leu Ser Asn Asp Ile
        435                 440                 445             
Val Ser Thr Lys Arg Glu Gln Arg Glu Lys His Cys Val Ser Thr Val
    450                 455                 460                 
Gln Cys Tyr Met Lys Gln His Glu Ile Thr Met Asp Glu Ala Cys Glu
465                 470                 475                 480 
Gln Ile Lys Glu Leu Thr Glu Asp Ser Trp Lys Phe Met Ile Glu Gln
                485                 490                 495     
Gly Leu Ala Leu Lys Glu Tyr Pro Ile Ile Val Pro Arg Thr Val Leu
            500                 505                 510         
Glu Phe Ala Arg Thr Val Asp Tyr Met Tyr Lys Glu Ala Asp Lys Tyr
        515                 520                 525             
Thr Val Ser His Thr Ile Lys Asp Met Leu Thr Ser Leu Tyr Val Lys
    530                 535                 540                 
Pro Val Leu Met
545             


<210> 509
<211> 548
<212> PRT
<213> Zea mays

<220> 
<223> (-)-beta-macrocarpene synthase Acc. No. AAT70085

<400> 509
Met Ala Ala Pro Thr Leu Thr Ala Asp Gly Pro Arg Leu Gly Gln Gln
 1               5                  10                  15      
Glu Met Lys Lys Met Ser Pro Ser Phe His Pro Thr Leu Trp Gly Asp
            20                  25                  30          
Phe Phe Leu Ser Tyr Glu Ala Pro Thr Glu Ala Gln Glu Ala Gln Met
        35                  40                  45              
Arg Glu Lys Ala Ala Val Leu Lys Glu Glu Val Arg Asn Met Ile Lys
    50                  55                  60                  
Gly Ser His Asp Val Pro Glu Ile Val Asp Leu Ile Ile Thr Leu Gln
65                  70                  75                  80  
Arg Leu Asn Leu Asp Tyr His Tyr Glu Asp Glu Ile Asn Glu Lys Leu
                85                  90                  95      
Thr Val Val Tyr Lys Ser Asn Tyr Asp Gly Gly Asn Leu Asp Leu Val
            100                 105                 110         
Ser Arg Arg Phe Tyr Leu Leu Arg Lys Cys Gly Tyr Asp Val Ser Ser
        115                 120                 125             
Asp Val Phe Leu Lys Phe Lys Asp Gln Leu Gly Asn Phe Val Glu Ala
    130                 135                 140                 
Asp Thr Arg Ser Leu Leu Ser Leu Tyr Asn Ala Ala Phe Leu Arg Ile
145                 150                 155                 160 
His Gly Glu Thr Val Leu Asp Glu Ala Ile Ser Phe Thr Met Arg Val
                165                 170                 175     
Leu Gln Asp Arg Leu Glu His Leu Glu Ser Pro Leu Ala Glu Glu Val
            180                 185                 190         
Ser Ser Ala Leu Asp Ala Pro Leu Phe Arg Arg Val Gly Thr Leu Glu
        195                 200                 205             
Met Lys Asp Tyr Ile Pro Ile Tyr Glu Lys Asp Ala Lys Gln Asn Lys
    210                 215                 220                 
Ser Ile Leu Glu Phe Ala Lys Leu Asn Phe Asn Leu Leu Gln Leu Arg
225                 230                 235                 240 
Tyr Ser Ser Glu Leu Lys Glu Cys Thr Thr Trp Trp Lys Glu Leu Arg
                245                 250                 255     
Val Glu Ser Asn Leu Ser Phe Val Arg Asp Arg Ile Val Glu Val Tyr
            260                 265                 270         
Phe Trp Met Ser Gly Gly Cys Tyr Asp Pro Gln Tyr Ser His Ser Arg
        275                 280                 285             
Ile Ile Leu Thr Lys Ile Val Ala Phe Ile Thr Ile Leu Asp Asp Thr
    290                 295                 300                 
Leu Asp Ser His Ala Thr Ser Cys Glu Ser Met Gln Leu Ala Glu Ala
305                 310                 315                 320 
Ile Glu Arg Trp Asp Glu Ser Ala Val Ser Leu Leu Pro Glu Tyr Met
                325                 330                 335     
Lys Asp Phe Tyr Met Tyr Leu Leu Lys Thr Phe Ser Ser Phe Glu Asn
            340                 345                 350         
Glu Leu Gly Pro Asp Lys Ser Tyr Arg Val Phe Tyr Leu Lys Glu Ala
        355                 360                 365             
Val Lys Glu Leu Val Arg Glu Tyr Thr Lys Glu Ile Lys Trp Arg Asp
    370                 375                 380                 
Glu Asp Tyr Val Pro Lys Thr Leu Lys Glu His Leu Lys Val Ser Leu
385                 390                 395                 400 
Ile Ser Ile Gly Gly Thr Leu Val Leu Cys Ser Ala Phe Val Gly Met
                405                 410                 415     
Gly Asp Val Val Thr Lys Lys Ile Met Lys Trp Val Met Ser Asp Ala
            420                 425                 430         
Glu Leu Val Lys Ser Phe Gly Ile Phe Val Arg Leu Ser Asn Asp Ile
        435                 440                 445             
Val Ser Thr Lys Arg Glu Gln Arg Glu Lys His Cys Val Ser Thr Val
    450                 455                 460                 
Gln Cys Tyr Met Lys Gln His Glu Ile Thr Met Asp Glu Ala Cys Glu
465                 470                 475                 480 
Gln Ile Lys Glu Leu Thr Glu Asp Ser Trp Lys Phe Met Ile Glu Gln
                485                 490                 495     
Gly Leu Ala Leu Lys Glu Tyr Pro Ile Ile Val Pro Arg Thr Val Leu
            500                 505                 510         
Glu Phe Ala Arg Thr Val Asp Tyr Met Tyr Lys Glu Ala Asp Lys Tyr
        515                 520                 525             
Thr Val Ser His Thr Ile Lys Asp Met Leu Thr Ser Leu Tyr Val Lys
    530                 535                 540                 
Pro Val Leu Met
545             


<210> 510
<211> 548
<212> PRT
<213> Zea mays

<220> 
<223> (-)-beta-macrocarpene synthase Acc. No. ACF58240

<400> 510
Met Ala Ala Pro Thr Leu Thr Thr Asp Gly Pro Arg Leu Gly Gln Gln
 1               5                  10                  15      
Glu Met Lys Lys Met Ser Pro Ser Phe His Pro Thr Leu Trp Gly Asp
            20                  25                  30          
Phe Phe Leu Ser Tyr Glu Ala Pro Thr Glu Ala Gln Glu Ala Glu Met
        35                  40                  45              
Arg Gln Arg Ala Glu Val Leu Arg Glu Glu Val Arg Asn Met Ile Lys
    50                  55                  60                  
Gly Ser His Asp Val Pro Glu Ile Val Asp Leu Ile Ile Thr Leu Gln
65                  70                  75                  80  
Arg Leu Asn Leu Asp Tyr His Tyr Glu Asp Glu Ile Asn Glu Lys Leu
                85                  90                  95      
Ala Val Val Tyr Asn Ser Asn Tyr Asp Gly Gly Asn Leu Asp Leu Val
            100                 105                 110         
Ser Arg Arg Phe Tyr Leu Leu Arg Lys Cys Gly Tyr His Val Ser Ser
        115                 120                 125             
Asp Val Phe Leu Asn Phe Lys Asp Gln Tyr Gly Asn Phe Ile Glu Val
    130                 135                 140                 
Asp Thr Arg Ser Leu Leu Ser Leu Tyr Asn Ala Ala Tyr Leu Arg Ile
145                 150                 155                 160 
His Gly Glu Thr Val Leu Asp Glu Ala Ile Ser Phe Thr Thr Arg Cys
                165                 170                 175     
Leu Gln Asp Arg Leu Glu His Leu Glu Ser Pro Ile Ala Glu Glu Val
            180                 185                 190         
Ser Ser Ala Leu Asp Thr Pro Leu Phe Arg Arg Val Gly Thr Leu Glu
        195                 200                 205             
Met Lys Asp Tyr Ile Pro Ile Tyr Glu Lys Asp Ala Lys Gln Asn Lys
    210                 215                 220                 
Ser Ile Leu Glu Phe Ala Lys Leu Asn Phe Asn Leu Leu Gln Leu Leu
225                 230                 235                 240 
Tyr Ser Ser Glu Leu Lys Glu Cys Thr Thr Trp Trp Lys Glu Leu Arg
                245                 250                 255     
Val Glu Ser Asn Leu Ser Phe Val Arg Asp Arg Ile Val Glu Val Tyr
            260                 265                 270         
Phe Trp Met Ser Gly Gly Cys Tyr Asp Pro Gln Tyr Ser His Ser Arg
        275                 280                 285             
Ile Ile Leu Thr Lys Ile Val Ala Phe Ile Thr Ile Leu Asp Asp Thr
    290                 295                 300                 
Leu Asp Ser His Ala Asn Ser Tyr Glu Ser Met Gln Leu Ala Glu Ala
305                 310                 315                 320 
Val Glu Arg Trp Asp Glu Ser Ala Val Ser Leu Leu Pro Glu Tyr Met
                325                 330                 335     
Lys Asp Phe Tyr Met Tyr Leu Leu Lys Thr Phe Ser Ser Phe Glu Asn
            340                 345                 350         
Glu Leu Gly Pro Asp Lys Ser Tyr Arg Val Phe Tyr Leu Lys Glu Ala
        355                 360                 365             
Val Lys Glu Leu Val Arg Glu Tyr Thr Lys Glu Ile Lys Trp Arg Asp
    370                 375                 380                 
Glu Asp Tyr Val Pro Lys Thr Leu Lys Glu His Leu Lys Val Ser Leu
385                 390                 395                 400 
Ile Ser Ile Gly Gly Thr Leu Val Leu Cys Ser Ala Phe Val Gly Met
                405                 410                 415     
Gly Asp Val Val Thr Lys Lys Ile Met Glu Trp Val Met Ser Asp Ala
            420                 425                 430         
Glu Leu Val Lys Ser Phe Gly Ile Phe Val Arg Leu Ser Asn Asp Ile
        435                 440                 445             
Val Ser Thr Lys Arg Glu Gln Arg Glu Lys His Cys Val Ser Thr Val
    450                 455                 460                 
Gln Cys Tyr Met Lys Gln His Glu Leu Thr Met Asp Glu Ala Cys Glu
465                 470                 475                 480 
Gln Ile Lys Glu Leu Thr Glu Asp Ser Trp Lys Phe Met Ile Glu Gln
                485                 490                 495     
Gly Leu Ala Leu Lys Glu Tyr Pro Ile Ile Val Pro Arg Thr Val Leu
            500                 505                 510         
Glu Phe Ala Arg Thr Val Asp Tyr Met Tyr Lys Glu Ala Asp Lys Tyr
        515                 520                 525             
Thr Val Ser His Thr Ile Lys Asp Met Leu Thr Ser Leu Tyr Val Lys
    530                 535                 540                 
Pro Val Leu Met
545             


<210> 511
<211> 547
<212> PRT
<213> Zea mays

<220> 
<223> (E)-beta-caryophyllene synthase Acc. No. ABY79206

<400> 511
Met Ala Ala Asp Glu Ala Arg Ser Val Ser Arg Leu His Ser Glu Glu
 1               5                  10                  15      
Asp Met His Gly Lys His His Ser Thr Leu Trp Gly Asp Phe Phe Leu
            20                  25                  30          
His His Val Pro Cys Arg Pro Gly Gln Tyr Leu Ile Met Lys Asp Asn
        35                  40                  45              
Val Glu Ile Met Lys Glu Glu Val Lys Lys Met Leu Leu Asp Val Gly
    50                  55                  60                  
Ser Ser Asp Leu Ser His Lys Leu Asp Cys Ile Asp Thr Leu Glu Arg
65                  70                  75                  80  
Leu Gly Leu Asp Tyr His Tyr Thr Lys Glu Ile Asp Glu Leu Met Cys
                85                  90                  95      
Asn Val Phe Glu Ala Arg Asp Gln Asp Leu Asp Leu Thr Thr Thr Ser
            100                 105                 110         
Gln Leu Phe Tyr Leu Leu Arg Lys His Gly Tyr His Ile Ser Ser Asp
        115                 120                 125             
Val Phe Leu Lys Phe Arg Asp Asp Lys Gly Asp Ile Val Thr Asn Asp
    130                 135                 140                 
Ala Arg Cys Leu Leu Arg Met Tyr Glu Ala Ala His Val Arg Val Asn
145                 150                 155                 160 
Gly Glu Glu Ile Leu Asp Asn Ile Leu Ile His Thr Lys Arg Gln Leu
                165                 170                 175     
Gln Cys Ile Val Asp Asp Leu Glu Pro Thr Leu Gln Glu Glu Val Arg
            180                 185                 190         
Tyr Ala Leu Glu Thr Pro Leu Phe Arg Arg Leu Asn Arg Val Gln Ala
        195                 200                 205             
Arg Gln Phe Ile Ser Thr Tyr Glu Lys Ser Thr Thr Arg Ile Asn Met
    210                 215                 220                 
Leu Leu Glu Phe Ser Lys Leu Asp Phe Asn Ile Leu Leu Thr Leu Tyr
225                 230                 235                 240 
Cys Glu Glu Leu Lys Asp Leu Thr Leu Trp Trp Lys Glu Phe Gln Ala
                245                 250                 255     
Gln Ala Asn Thr Thr Ile Tyr Ala Arg Asp Arg Met Val Glu Met His
            260                 265                 270         
Phe Trp Met Met Gly Val Phe Phe Glu Pro Gln Tyr Ser Tyr Ser Arg
        275                 280                 285             
Lys Met Leu Thr Gln Leu Phe Met Ile Val Ser Val Leu Asp Asp Leu
    290                 295                 300                 
Tyr Asp Ser His Cys Thr Thr Glu Glu Gly Asn Ala Phe Thr Ala Ala
305                 310                 315                 320 
Leu Gln Arg Trp Asp Glu Glu Gly Val Glu Gln Cys Pro Thr Tyr Leu
                325                 330                 335     
Arg Thr Leu Tyr Thr Asn Ile Arg Ala Thr Ile Lys Ala Ile Glu Glu
            340                 345                 350         
Asp Leu Asn Phe Gln Asn Asn Lys His Ala Lys Leu Val Lys Gly Leu
        355                 360                 365             
Ile Ile Asp Met Ala Met Cys Tyr Asn Ala Glu Thr Glu Trp Arg Asp
    370                 375                 380                 
Lys Lys Tyr Val Pro Ala Thr Val Asp Glu His Leu Lys Ile Ser Ala
385                 390                 395                 400 
Arg Ser Ser Gly Cys Met His Leu Val Ser Gln Gly Phe Ile Ser Met
                405                 410                 415     
Gly Asp Val Ala Thr Ser Glu Ala Leu Glu Trp Ala Ser Thr Tyr Pro
            420                 425                 430         
Lys Ile Val Arg Ala Val Cys Ile Ile Ala Arg Leu Ala Asn Asp Ile
        435                 440                 445             
Met Ser Tyr Lys Arg Glu Ala Ser Asn Asn Thr Met Val Ser Thr Val
    450                 455                 460                 
Gln Thr Cys Ala Lys Glu Tyr Gly Thr Thr Thr Val Glu Gln Ala Ile
465                 470                 475                 480 
Glu Lys Ile Arg Glu Leu Ile Glu Glu Ala Trp Met Asp Ile Thr His
                485                 490                 495     
Glu Cys Leu Arg Gln Pro Gln Pro Lys Ala Leu Leu Glu Arg Ala Val
            500                 505                 510         
Asn Leu Ala Arg Thr Met Asp Phe Leu Tyr Lys Asp Ala Asp Gly Tyr
        515                 520                 525             
Thr Asp Ser Arg Ser Ile Lys Gly Ile Leu Asp Ser Leu Tyr Val His
    530                 535                 540                 
Leu Ile Asp
545         


<210> 512
<211> 590
<212> PRT
<213> Zea mays

<220> 
<223> (E,E)-farnesol synthase Acc. No. AAO18435

<400> 512
Met Ala Met Pro Val Lys Leu Thr Pro Ala Ser Leu Ser Leu Lys Ala
 1               5                  10                  15      
Val Cys Cys Arg Phe Ser Ser Gly Gly His Ala Leu Arg Phe Gly Ser
            20                  25                  30          
Ser Leu Pro Cys Trp Arg Arg Thr Pro Thr Gln Arg Ser Thr Ser Ser
        35                  40                  45              
Ser Thr Thr Arg Pro Ala Ala Glu Val Ser Ser Gly Lys Ser Lys Gln
    50                  55                  60                  
His Asp Gln Glu Ala Ser Glu Ala Thr Ile Arg Gln Gln Leu Gln Leu
65                  70                  75                  80  
Val Asp Val Leu Glu Asn Met Gly Ile Ser Arg His Phe Ala Ala Glu
                85                  90                  95      
Ile Lys Cys Ile Leu Asp Arg Thr Tyr Arg Ser Trp Leu Gln Arg His
            100                 105                 110         
Glu Glu Ile Met Leu Asp Thr Met Thr Cys Ala Met Ala Phe Arg Ile
        115                 120                 125             
Leu Arg Leu Asn Gly Tyr Asn Val Ser Ser Asp Glu Leu Tyr His Val
    130                 135                 140                 
Val Glu Ala Ser Gly Leu His Asn Ser Leu Gly Gly Tyr Leu Asn Asp
145                 150                 155                 160 
Thr Arg Thr Leu Leu Glu Leu His Lys Ala Ser Thr Val Ser Ile Ser
                165                 170                 175     
Glu Asp Glu Ser Ile Leu Asp Ser Ile Gly Ser Arg Ser Arg Thr Leu
            180                 185                 190         
Leu Arg Glu Gln Leu Glu Ser Gly Gly Ala Leu Arg Lys Pro Ser Leu
        195                 200                 205             
Phe Lys Glu Val Glu His Ala Leu Asp Gly Pro Phe Tyr Thr Thr Leu
    210                 215                 220                 
Asp Arg Leu His His Arg Trp Asn Ile Glu Asn Phe Asn Ile Ile Glu
225                 230                 235                 240 
Gln His Met Leu Glu Thr Pro Tyr Leu Ser Asn Gln His Thr Ser Arg
                245                 250                 255     
Asp Ile Leu Ala Leu Ser Ile Arg Asp Phe Ser Ser Ser Gln Phe Thr
            260                 265                 270         
Tyr Gln Gln Glu Leu Gln His Leu Glu Ser Trp Val Lys Glu Cys Arg
        275                 280                 285             
Leu Asp Gln Leu Gln Phe Ala Arg Gln Lys Leu Ala Tyr Phe Tyr Leu
    290                 295                 300                 
Ser Ala Ala Gly Thr Met Phe Ser Pro Glu Leu Ser Asp Ala Arg Thr
305                 310                 315                 320 
Leu Trp Ala Lys Asn Gly Val Leu Thr Thr Ile Val Asp Asp Phe Phe
                325                 330                 335     
Asp Val Ala Gly Ser Lys Glu Glu Leu Glu Asn Leu Val Met Leu Val
            340                 345                 350         
Glu Met Trp Asp Glu His His Lys Val Glu Phe Tyr Ser Glu Gln Val
        355                 360                 365             
Glu Ile Ile Phe Ser Ser Ile Tyr Asp Ser Val Asn Gln Leu Gly Glu
    370                 375                 380                 
Lys Ala Ser Leu Val Gln Asp Arg Ser Ile Thr Lys His Leu Val Glu
385                 390                 395                 400 
Ile Trp Leu Asp Leu Leu Lys Ser Met Met Thr Glu Val Glu Trp Arg
                405                 410                 415     
Leu Ser Lys Tyr Val Pro Thr Glu Lys Glu Tyr Met Ile Asn Ala Ser
            420                 425                 430         
Leu Ile Phe Gly Leu Gly Pro Ile Val Leu Pro Ala Leu Tyr Phe Val
        435                 440                 445             
Gly Pro Lys Ile Ser Glu Ser Ile Val Lys Asp Pro Glu Tyr Asp Glu
    450                 455                 460                 
Leu Phe Lys Leu Met Ser Thr Cys Gly Arg Leu Leu Asn Asp Val Gln
465                 470                 475                 480 
Thr Phe Glu Arg Glu Tyr Asn Glu Gly Lys Leu Asn Ser Val Ser Leu
                485                 490                 495     
Leu Val Leu His Gly Gly Pro Met Ser Ile Ser Asp Ala Lys Arg Lys
            500                 505                 510         
Leu Gln Lys Pro Ile Asp Thr Cys Arg Arg Asp Leu Leu Ser Leu Val
        515                 520                 525             
Leu Arg Glu Glu Ser Val Val Pro Arg Pro Cys Lys Glu Leu Phe Trp
    530                 535                 540                 
Lys Met Cys Lys Val Cys Tyr Phe Phe Tyr Ser Thr Thr Asp Gly Phe
545                 550                 555                 560 
Ser Ser Gln Val Glu Arg Ala Lys Glu Val Asp Ala Val Ile Asn Glu
                565                 570                 575     
Pro Leu Lys Leu Gln Gly Ser His Thr Leu Val Ser Asp Val
            580                 585                 590 


<210> 513
<211> 554
<212> PRT
<213> Zea mays

<220> 
<223> sesquithujene synthase Acc. No. AAS88574

<400> 513
Met Ala Ser Pro Pro Ala His Arg Ser Ser Lys Ala Ala Asp Glu Glu
 1               5                  10                  15      
Leu Pro Lys Ala Ser Ser Thr Phe His Pro Ser Leu Trp Gly Ser Phe
            20                  25                  30          
Phe Leu Thr Tyr Gln Pro Pro Thr Ala Pro Gln Arg Ala Asn Met Lys
        35                  40                  45              
Glu Arg Ala Glu Val Leu Arg Glu Arg Val Arg Lys Val Leu Lys Gly
    50                  55                  60                  
Ser Thr Thr Asp Gln Leu Pro Glu Thr Val Asn Leu Ile Leu Thr Leu
65                  70                  75                  80  
Gln Arg Leu Gly Leu Gly Tyr Tyr Tyr Glu Asn Glu Ile Asp Lys Leu
                85                  90                  95      
Leu His Gln Ile Tyr Ser Asn Ser Asp Tyr Asn Glu Lys Asp Leu Asn
            100                 105                 110         
Leu Val Ser Gln Arg Phe Tyr Leu Leu Arg Lys Asn Gly Tyr Asp Val
        115                 120                 125             
Pro Ser Asp Val Phe Leu Asn Phe Lys Thr Glu Glu Gly Gly Phe Ala
    130                 135                 140                 
Cys Ala Ala Ala Asp Thr Arg Ser Leu Leu Ser Leu Tyr Asn Ala Ala
145                 150                 155                 160 
Tyr Leu Arg Lys His Gly Glu Glu Val Leu Asp Glu Ala Ile Ser Ser
                165                 170                 175     
Thr Arg Leu Arg Leu Gln Asp Leu Leu Gly Arg Leu Leu Pro Glu Ser
            180                 185                 190         
Pro Phe Ala Lys Glu Val Ser Ser Ser Leu Arg Thr Pro Leu Phe Arg
        195                 200                 205             
Arg Val Gly Ile Leu Glu Ala Arg Asn Tyr Ile Pro Ile Tyr Glu Lys
    210                 215                 220                 
Glu Ala Thr Arg Asn Glu Ala Val Leu Glu Leu Ala Lys Leu Asn Phe
225                 230                 235                 240 
Asn Leu Gln Gln Leu Asp Phe Cys Glu Glu Leu Lys His Cys Ser Ala
                245                 250                 255     
Trp Trp Asn Glu Met Ile Ala Lys Ser Lys Leu Thr Phe Val Arg Asp
            260                 265                 270         
Arg Ile Val Glu Glu Tyr Phe Trp Met Asn Gly Ala Cys Cys Asp Pro
        275                 280                 285             
Pro Tyr Ser Leu Ser Arg Ile Ile Leu Thr Lys Ile Thr Gly Leu Ile
    290                 295                 300                 
Thr Ile Ile Asp Asp Met Phe Asp Thr His Gly Thr Thr Glu Asp Cys
305                 310                 315                 320 
Met Lys Phe Ala Glu Ala Phe Gly Arg Trp Asp Glu Ser Ala Ile His
                325                 330                 335     
Leu Leu Pro Glu Tyr Met Lys Asp Phe Tyr Ile Leu Met Leu Glu Thr
            340                 345                 350         
Phe Gln Ser Phe Glu Asp Ala Leu Gly Pro Glu Lys Ser Tyr Arg Val
        355                 360                 365             
Leu Tyr Leu Lys Gln Ala Met Glu Arg Leu Val Glu Leu Tyr Ser Lys
    370                 375                 380                 
Glu Ile Lys Trp Arg Asp Gln Asp Tyr Val Ala Thr Met Ser Glu His
385                 390                 395                 400 
Leu Gln Val Ser Ala Glu Ser Ile Gly Ala Asn Ala Leu Thr Cys Ser
                405                 410                 415     
Ala Tyr Ala Gly Met Gly Asp Met Ser Ile Thr Lys Glu Thr Phe Glu
            420                 425                 430         
Trp Ala Leu Ser Phe Pro Gln Phe Ile Arg Thr Phe Gly Ser Phe Val
        435                 440                 445             
Arg Leu Ser Asn Asp Val Val Ser Thr Lys Arg Glu Gln Thr Lys Asp
    450                 455                 460                 
His Ser Pro Ser Thr Val His Cys Tyr Met Lys Glu His Gly Thr Thr
465                 470                 475                 480 
Met Asp Asp Ala Cys Glu Lys Ile Lys Glu Leu Ile Glu Asp Ser Trp
                485                 490                 495     
Lys Asp Met Leu Glu Gln Ser Leu Ala Leu Lys Gly Leu Pro Lys Val
            500                 505                 510         
Val Pro Gln Leu Val Phe Asp Phe Ser Arg Thr Thr Asp Asn Met Tyr
        515                 520                 525             
Arg Asp Arg Asp Ala Leu Thr Ser Ser Glu Ala Leu Lys Glu Met Ile
    530                 535                 540                 
Gln Leu Leu Phe Val Glu Pro Ile Pro Glu
545                 550                 


<210> 514
<211> 554
<212> PRT
<213> Zea mays

<220> 
<223> S-beta-bisabolene synthase Acc. No. AAS88571

<400> 514
Met Ala Ser Pro Pro Ala His Arg Ser Ser Lys Ala Ala Asp Glu Glu
 1               5                  10                  15      
Leu Pro Lys Ala Ser Ser Thr Phe His Pro Ser Leu Trp Gly Ser Phe
            20                  25                  30          
Phe Leu Thr Tyr Gln Pro Pro Thr Ala Pro Gln Arg Ala Asn Met Lys
        35                  40                  45              
Glu Arg Ala Glu Val Leu Arg Glu Arg Val Arg Lys Val Leu Lys Gly
    50                  55                  60                  
Ser Thr Thr Asp Gln Leu Pro Glu Thr Val Asn Leu Ile Leu Thr Leu
65                  70                  75                  80  
Gln Arg Leu Gly Leu Gly Tyr Tyr Tyr Glu Asn Glu Ile Asp Lys Leu
                85                  90                  95      
Leu His Gln Ile Tyr Ser Asn Ser Asp Tyr Asn Val Lys Asp Leu Asn
            100                 105                 110         
Leu Val Ser Gln Arg Phe Tyr Leu Leu Arg Lys Asn Gly Tyr Asp Val
        115                 120                 125             
Pro Ser Asp Val Phe Leu Ser Phe Lys Thr Glu Glu Gly Gly Phe Ala
    130                 135                 140                 
Cys Ala Ala Ala Asp Thr Arg Ser Leu Leu Ser Leu Tyr Asn Ala Ala
145                 150                 155                 160 
Tyr Leu Arg Lys His Gly Glu Glu Val Leu Asp Glu Ala Ile Ser Ser
                165                 170                 175     
Thr Arg Leu Arg Leu Gln Asp Leu Leu Gly Arg Leu Leu Pro Glu Ser
            180                 185                 190         
Pro Phe Ala Lys Glu Val Ser Ser Ser Leu Arg Thr Pro Leu Phe Arg
        195                 200                 205             
Arg Val Gly Ile Leu Glu Ala Arg Asn Tyr Ile Pro Ile Tyr Glu Thr
    210                 215                 220                 
Glu Ala Thr Arg Asn Glu Ala Val Leu Glu Leu Ala Lys Leu Asn Phe
225                 230                 235                 240 
Asn Leu Gln Gln Leu Asp Phe Cys Glu Glu Leu Lys His Cys Ser Ala
                245                 250                 255     
Trp Trp Asn Glu Met Ile Ala Lys Ser Lys Leu Thr Phe Val Arg Asp
            260                 265                 270         
Arg Ile Val Glu Glu Tyr Phe Trp Met Asn Gly Ala Cys Tyr Asp Pro
        275                 280                 285             
Pro Tyr Ser Leu Ser Arg Ile Ile Leu Thr Lys Ile Thr Gly Leu Ile
    290                 295                 300                 
Thr Ile Ile Asp Asp Met Phe Asp Thr His Gly Thr Thr Glu Asp Cys
305                 310                 315                 320 
Met Lys Phe Ala Glu Ala Phe Gly Arg Trp Asp Glu Ser Ala Ile His
                325                 330                 335     
Leu Leu Pro Glu Tyr Met Lys Asp Phe Tyr Ile Leu Met Leu Glu Thr
            340                 345                 350         
Phe Gln Ser Phe Glu Asp Ala Leu Gly Pro Glu Lys Ser Tyr Arg Val
        355                 360                 365             
Leu Tyr Leu Lys Gln Ala Met Glu Arg Leu Val Glu Leu Tyr Ser Lys
    370                 375                 380                 
Glu Ile Lys Trp Arg Asp Asp Asp Tyr Val Pro Thr Met Ser Glu His
385                 390                 395                 400 
Leu Gln Val Ser Ala Glu Thr Ile Ala Thr Ile Ala Leu Thr Cys Ser
                405                 410                 415     
Ala Tyr Ala Gly Met Gly Asp Met Ser Ile Arg Lys Glu Thr Phe Glu
            420                 425                 430         
Trp Ala Leu Ser Phe Pro Gln Phe Ile Arg Thr Phe Gly Ser Phe Val
        435                 440                 445             
Arg Leu Ser Asn Asp Val Val Ser Thr Lys Arg Glu Gln Thr Lys Asp
    450                 455                 460                 
His Ser Pro Ser Thr Val His Cys Tyr Met Lys Glu His Gly Thr Thr
465                 470                 475                 480 
Met Asp Asp Ala Cys Glu Lys Ile Lys Glu Leu Ile Glu Asp Ser Trp
                485                 490                 495     
Lys Asp Met Leu Glu Gln Ser Leu Ala Leu Lys Gly Leu Pro Lys Val
            500                 505                 510         
Val Pro Gln Leu Val Phe Asp Phe Ser Arg Thr Thr Asp Asn Met Tyr
        515                 520                 525             
Arg Asp Arg Asp Ala Leu Thr Ser Ser Glu Ala Leu Lys Glu Met Ile
    530                 535                 540                 
Gln Leu Leu Phe Val Glu Pro Ile Pro Glu
545                 550                 


<210> 515
<211> 547
<212> PRT
<213> Zea mays

<220> 
<223> mexicana (E)-beta-caryophyllene synthase Acc. No.
      ABY79212

<400> 515
Met Ala Ala Asp Glu Ala Arg Ser Val Ser Arg Leu His Ser Glu Glu
 1               5                  10                  15      
Asp Met His Gly Lys His His Ser Thr Leu Trp Gly Asp Phe Phe Leu
            20                  25                  30          
His His Val Pro Cys Arg Pro Gly Gln Tyr Leu Ile Met Lys Asp Asn
        35                  40                  45              
Val Glu Ile Met Lys Glu Glu Val Lys Lys Met Leu Leu Asp Val Gly
    50                  55                  60                  
Ser Ser Asp Leu Ser His Lys Leu Asp Cys Ile Asp Thr Leu Glu Arg
65                  70                  75                  80  
Leu Gly Leu Asp Tyr His Tyr Thr Lys Glu Ile Asp Glu Leu Met Cys
                85                  90                  95      
Asn Val Phe Glu Ala Arg Asp Gln Asp Leu Asp Leu Thr Thr Thr Ser
            100                 105                 110         
Gln Leu Phe Tyr Leu Leu Arg Lys His Gly Tyr His Ile Ser Ser Asp
        115                 120                 125             
Val Phe Leu Lys Phe Arg Asp Asp Lys Gly Asp Ile Val Thr Asn Asp
    130                 135                 140                 
Ala Arg Cys Leu Leu Arg Met Tyr Glu Ala Ala His Val Arg Val Asn
145                 150                 155                 160 
Gly Glu Glu Ile Leu Asp Asn Ile Leu Ile His Thr Lys Arg Gln Leu
                165                 170                 175     
Gln Cys Ile Val Asp Asp Leu Glu Pro Thr Leu Gln Glu Glu Val Arg
            180                 185                 190         
Tyr Ala Leu Glu Thr Pro Leu Phe Arg Arg Leu Asn Arg Val Gln Ala
        195                 200                 205             
Arg Gln Phe Ile Ser Thr Tyr Glu Lys Ser Thr Thr Arg Asn Asn Met
    210                 215                 220                 
Leu Leu Glu Phe Ser Lys Leu Asp Phe Asn Ile Leu Leu Thr Leu Tyr
225                 230                 235                 240 
Cys Glu Glu Leu Lys Asp Leu Thr Leu Trp Trp Lys Glu Phe Gln Ala
                245                 250                 255     
Gln Ala Asn Thr Thr Ile Tyr Ala Arg Asp Arg Met Val Glu Met His
            260                 265                 270         
Phe Trp Met Met Gly Val Phe Phe Glu Pro Gln Tyr Ser Tyr Ser Arg
        275                 280                 285             
Lys Met Leu Thr Gln Leu Phe Met Ile Val Ser Val Leu Asp Asp Leu
    290                 295                 300                 
Tyr Asp Ser His Cys Thr Thr Glu Glu Gly Asn Ala Phe Thr Ala Ala
305                 310                 315                 320 
Leu Gln Arg Trp Asp Glu Glu Gly Val Glu Gln Cys Pro Thr Tyr Leu
                325                 330                 335     
Arg Thr Leu Tyr Thr Asn Ile Arg Ala Thr Val Lys Ala Ile Glu Glu
            340                 345                 350         
Asp Leu Asn Leu Gln Asn Asn Lys His Ala Lys Leu Val Lys Gly Leu
        355                 360                 365             
Ile Ile Asp Met Ala Met Cys Tyr Asn Ala Glu Thr Glu Trp Arg Asp
    370                 375                 380                 
Lys Lys Tyr Val Pro Ala Thr Val Asp Glu His Leu Lys Ile Ser Ala
385                 390                 395                 400 
Arg Ser Ser Gly Cys Met His Leu Val Ser Gln Gly Phe Ile Ser Met
                405                 410                 415     
Gly Asp Val Ala Thr Ser Glu Ala Leu Glu Trp Ala Ser Thr Tyr Pro
            420                 425                 430         
Lys Ile Val Arg Ala Val Cys Ile Ile Ala Arg Leu Ala Asn Asp Ile
        435                 440                 445             
Met Ser Tyr Lys Arg Glu Ala Ser Asn Asn Thr Met Val Ser Thr Val
    450                 455                 460                 
Gln Thr Cys Ala Lys Glu Tyr Gly Thr Thr Thr Val Glu Gln Ala Ile
465                 470                 475                 480 
Glu Lys Ile Arg Glu Leu Ile Glu Glu Ala Trp Met Asp Ile Thr His
                485                 490                 495     
Glu Cys Leu Arg Gln Pro Gln Pro Met Ala Leu Leu Glu Arg Ala Val
            500                 505                 510         
Asn Leu Ala Arg Thr Met Asp Phe Leu Tyr Lys Asp Val Asp Gly Tyr
        515                 520                 525             
Thr Asp Ser Arg Ser Ile Lys Gly Ile Leu Asp Ser Leu Tyr Val His
    530                 535                 540                 
Leu Ile Asp
545         


<210> 516
<211> 547
<212> PRT
<213> Zea mays

<220> 
<223> parviglumis (E)-beta-caryophyllene synthase Acc.
      No. ABY79213

<400> 516
Met Ala Ala Asp Glu Ala Arg Ser Val Ser Arg Leu His Ser Glu Glu
 1               5                  10                  15      
Asp Met His Gly Lys His His Ser Thr Leu Trp Gly Asp Phe Phe Leu
            20                  25                  30          
His His Val Pro Cys Arg Pro Gly Gln Tyr Leu Ile Met Lys Asp Asn
        35                  40                  45              
Val Glu Ile Met Lys Glu Glu Val Lys Lys Met Leu Leu Asp Val Gly
    50                  55                  60                  
Ser Ser Asp Leu Ser His Lys Leu Asp Cys Ile Asp Thr Leu Glu Arg
65                  70                  75                  80  
Leu Gly Leu Asp Tyr His Tyr Thr Lys Glu Ile Asp Glu Leu Met Cys
                85                  90                  95      
Asn Val Phe Glu Ala Arg Asp Gln Asp Leu Asp Leu Thr Thr Thr Ser
            100                 105                 110         
Gln Leu Phe Tyr Leu Leu Arg Lys His Gly Tyr His Ile Ser Ser Asp
        115                 120                 125             
Val Phe Leu Lys Phe Arg Asp Asp Lys Gly Asp Ile Val Thr Asn Asp
    130                 135                 140                 
Ala Arg Cys Leu Leu Arg Met Tyr Glu Ala Ala His Val Arg Val Asn
145                 150                 155                 160 
Gly Glu Glu Ile Leu Asp Asn Ile Leu Ile His Thr Lys Arg Gln Leu
                165                 170                 175     
Gln Cys Ile Val Asp Asp Leu Glu Pro Thr Leu Gln Glu Glu Val Arg
            180                 185                 190         
Tyr Ala Leu Glu Thr Pro Leu Phe Arg Arg Leu Asn Arg Val Gln Ala
        195                 200                 205             
Arg Gln Phe Ile Ser Thr Tyr Glu Lys Ser Thr Thr Arg Asn Asn Met
    210                 215                 220                 
Leu Leu Glu Phe Ser Lys Leu Asp Phe Asn Ile Leu Leu Thr Leu Tyr
225                 230                 235                 240 
Cys Glu Glu Leu Lys Asp Leu Thr Leu Trp Trp Lys Glu Phe Gln Ala
                245                 250                 255     
Gln Ala Asn Thr Thr Ile Tyr Ala Arg Asp Arg Met Val Glu Met His
            260                 265                 270         
Phe Trp Met Met Gly Val Phe Phe Glu Pro Gln Tyr Ser Tyr Ser Arg
        275                 280                 285             
Lys Met Leu Thr Gln Leu Phe Met Ile Val Ser Val Leu Asp Asp Leu
    290                 295                 300                 
Tyr Asp Ser His Cys Thr Thr Glu Glu Gly Asn Ala Phe Thr Ala Ala
305                 310                 315                 320 
Leu Gln Arg Trp Asp Glu Glu Gly Val Glu Gln Cys Pro Thr Tyr Leu
                325                 330                 335     
Arg Thr Leu Tyr Thr Asn Ile Arg Ala Thr Ile Lys Ala Ile Glu Glu
            340                 345                 350         
Asp Leu Asn Phe Gln Asn Asn Lys His Ala Lys Leu Val Lys Gly Leu
        355                 360                 365             
Ile Ile Asp Met Ala Met Cys Tyr Asn Ala Glu Thr Glu Trp Arg Asp
    370                 375                 380                 
Lys Lys Tyr Val Pro Ala Thr Val Asp Glu His Leu Lys Ile Ser Ala
385                 390                 395                 400 
Arg Ser Ser Gly Cys Met His Leu Val Ser Gln Gly Phe Ile Ser Met
                405                 410                 415     
Gly Asp Val Ala Thr Ser Glu Ala Leu Glu Trp Ala Ser Thr Tyr Pro
            420                 425                 430         
Lys Ile Val Arg Ala Val Cys Ile Ile Ala Arg Leu Ala Asn Asp Ile
        435                 440                 445             
Met Ser Tyr Lys Arg Glu Ala Ser Asn Asn Thr Met Val Ser Thr Val
    450                 455                 460                 
Gln Thr Cys Ala Lys Glu Tyr Gly Thr Thr Thr Val Glu Gln Ala Ile
465                 470                 475                 480 
Glu Lys Ile Arg Glu Leu Ile Glu Glu Ala Trp Met Asp Ile Thr His
                485                 490                 495     
Glu Cys Leu Arg Gln Pro Gln Pro Lys Ala Leu Leu Glu Arg Ala Val
            500                 505                 510         
Asn Leu Ala Arg Thr Met Asp Phe Leu Tyr Lys Asp Ala Asp Gly Tyr
        515                 520                 525             
Thr Asp Ser Arg Ser Ile Lys Gly Ile Leu Asp Ser Leu Tyr Val His
    530                 535                 540                 
Leu Ile Asp
545         


<210> 517
<211> 547
<212> PRT
<213> Zea perennis

<220> 
<223> (E)-beta-caryophyllene synthase Acc. No. ABY79214

<400> 517
Met Ala Ala Asp Glu Ala Arg Ser Val Ser Lys Leu His Ser Glu Glu
 1               5                  10                  15      
Asp Met His Gly Lys His His Ser Thr Leu Trp Gly Asp Phe Phe Leu
            20                  25                  30          
His His Val Pro Cys Arg Pro Gly Gln Tyr Leu Ile Met Lys Asp Asn
        35                  40                  45              
Val Glu Ile Met Lys Glu Glu Val Lys Lys Met Leu Leu Asp Val Gly
    50                  55                  60                  
Ser Ser Asp Leu Ser His Lys Leu Asp Cys Ile Asp Thr Leu Glu Arg
65                  70                  75                  80  
Leu Gly Leu Gly Tyr His Tyr Thr Lys Glu Ile Asp Glu Leu Met Cys
                85                  90                  95      
Asn Val Phe Glu Ala Arg Asp Gln Asp Leu Asp Leu Thr Thr Thr Ser
            100                 105                 110         
Gln Leu Phe Tyr Leu Leu Arg Lys His Gly Tyr His Ile Ser Ser Asp
        115                 120                 125             
Val Phe Leu Lys Phe Arg Asp Asp Lys Gly Asp Ile Val Thr Asp Asp
    130                 135                 140                 
Ala Arg Cys Leu Leu Arg Met Tyr Glu Ala Ala His Val Arg Val Asn
145                 150                 155                 160 
Gly Glu Glu Ile Leu Asp Asn Ile Leu Ser His Thr Lys Arg Gln Leu
                165                 170                 175     
Gln Cys Ile Val Asp Asp Leu Glu Pro Thr Leu Gln Glu Glu Val Arg
            180                 185                 190         
Tyr Ala Leu Glu Thr Pro Leu Phe Arg Arg Leu Asn Arg Val Gln Ala
        195                 200                 205             
Arg Gln Phe Ile Ser Thr Tyr Glu Lys Ser Thr Thr Arg Asn Asn Met
    210                 215                 220                 
Leu Leu Glu Phe Ser Lys Leu Asp Phe Asn Ile Leu Leu Thr Leu Tyr
225                 230                 235                 240 
Cys Glu Glu Leu Lys Asp Leu Thr Leu Trp Trp Lys Glu Phe Gln Ala
                245                 250                 255     
Gln Ala Asn Thr Ala Ile Tyr Ala Arg Asp Arg Met Val Glu Met His
            260                 265                 270         
Phe Trp Met Met Gly Val Phe Phe Glu Pro Gln Tyr Ser Tyr Ser Arg
        275                 280                 285             
Lys Met Leu Thr Gln Leu Phe Met Ile Val Ser Val Leu Asp Asp Leu
    290                 295                 300                 
Tyr Asp Ser His Cys Thr Thr Glu Glu Gly Asn Thr Phe Thr Ala Ala
305                 310                 315                 320 
Leu Gln Arg Trp Asp Glu Glu Gly Val Glu Gln Cys Pro Thr Tyr Leu
                325                 330                 335     
Arg Thr Leu Tyr Thr Asn Ile Arg Ala Thr Val Lys Ala Ile Glu Glu
            340                 345                 350         
Asp Leu Asn Leu Gln Asn Asn Lys His Ala Lys Leu Val Lys Gly Leu
        355                 360                 365             
Ile Ile Asp Met Ala Met Cys Tyr Asn Ala Glu Thr Glu Trp Arg Asp
    370                 375                 380                 
Lys Lys Tyr Val Pro Ala Thr Val Asp Glu His Leu Lys Ile Ser Ala
385                 390                 395                 400 
Arg Ser Ser Gly Cys Met His Leu Val Ser Gln Gly Phe Ile Ser Met
                405                 410                 415     
Gly Asp Val Ala Thr Ser Glu Thr Leu Glu Trp Ala Ser Thr Tyr Pro
            420                 425                 430         
Lys Ile Val Arg Ala Val Cys Ile Ile Ala Arg Leu Ala Asn Asp Ile
        435                 440                 445             
Met Ser Tyr Lys Arg Glu Ala Ser Asn Asn Thr Met Val Ser Thr Val
    450                 455                 460                 
Gln Thr Cys Ala Lys Glu Tyr Gly Thr Thr Thr Val Glu Gln Ala Ile
465                 470                 475                 480 
Glu Lys Ile Arg Glu Leu Ile Glu Glu Ala Trp Met Asp Val Thr His
                485                 490                 495     
Glu Cys Leu Arg Gln Pro Gln Pro Lys Ala Leu Leu Glu Arg Ala Val
            500                 505                 510         
Asn Leu Ala Arg Thr Met Asp Phe Leu Tyr Lys Asp Val Asp Gly Tyr
        515                 520                 525             
Thr Asp Ser Arg Ser Ile Lys Gly Ile Leu Asp Ser Leu Tyr Val His
    530                 535                 540                 
Leu Ile Asp
545         


<210> 518
<211> 550
<212> PRT
<213> Zingiber officinale

<220> 
<223> germacrene D synthase Acc. No. AAX40665

<400> 518
Met Glu Asn Gln Ser Leu Thr Phe Val Gly Asp Glu Glu Ala Lys Val
 1               5                  10                  15      
Arg Lys Ser Thr Lys Phe His Pro Ser Ile Trp Gly Asp Tyr Phe Ile
            20                  25                  30          
Gln Asn Ser Ser Leu Ser His Ala Glu Glu Ser Thr Gln Arg Met Ile
        35                  40                  45              
Lys Arg Val Glu Glu Leu Lys Val Gln Val Lys Ser Met Phe Lys Asp
    50                  55                  60                  
Thr Ser Asp Ile Leu Gln Leu Met Asn Leu Ile Asp Ser Ile Gln Met
65                  70                  75                  80  
Leu Gly Leu Asp Tyr His Phe Glu Asn Glu Ile Asp Lys Ala Leu Arg
                85                  90                  95      
Leu Ile Asn Glu Val Asp Asp Lys Ser Tyr Gly Leu Tyr Glu Thr Ser
            100                 105                 110         
Leu Arg Phe Arg Leu Leu Arg Gln His Gly Asn His Val Ser Thr Asp
        115                 120                 125             
Ile Phe Asn Lys Phe Lys Gly Asp Asn Gly Ser Phe Ile Ser Ser Leu
    130                 135                 140                 
Asn Gly Asp Ala Lys Gly Leu Leu Ser Leu Tyr Asn Ala Ser Tyr Leu
145                 150                 155                 160 
Gly Thr His Gly Glu Thr Ile Leu Asp Glu Ala Lys Ser Phe Ala Lys
                165                 170                 175     
Pro Gln Leu Ile Ser Leu Leu Ser Glu Leu Glu Gln Ser Leu Ala Ala
            180                 185                 190         
Gln Val Thr Leu Phe Leu Glu Leu Pro Leu His Lys Arg Val Lys Ile
        195                 200                 205             
Leu Leu Val Arg Lys Tyr Ile Leu Ile Tyr Gln Glu Gly Ala Met Arg
    210                 215                 220                 
Asn Asn Val Leu Leu Glu Phe Ala Lys Leu Asn Phe Asn Leu Leu Gln
225                 230                 235                 240 
Ser Leu Tyr Gln Glu Glu Leu Lys Lys Ile Ser Ile Trp Trp Tyr Asp
                245                 250                 255     
Leu Ala Leu Ala Lys Ser Leu Ser Phe Thr Arg Asp Arg Ile Val Glu
            260                 265                 270         
Cys Tyr Tyr Trp Val Leu Thr Leu Tyr Phe Asp Pro Gln Tyr Ser His
        275                 280                 285             
Ser Arg Leu Ile Tyr Ser Lys Val Ile Ser Leu Val Ser Ile Met Asp
    290                 295                 300                 
Asp Ile Tyr Asp Asn Tyr Gly Thr Leu Glu Glu Cys Arg Gln Leu Thr
305                 310                 315                 320 
Glu Ala Ile Lys Arg Trp Lys Pro Gln Ala Ile Asp Ser Leu Pro Glu
                325                 330                 335     
Tyr Leu Lys Tyr Phe Tyr Leu Lys Leu Leu Lys Thr Phe Glu Glu Ile
            340                 345                 350         
Gly Glu Glu Leu Glu His Asn Glu Lys Tyr Arg Met Leu Tyr Leu Gln
        355                 360                 365             
Asp Gln Ile Lys Ala Ile Ala Val Ala Tyr Leu Glu Glu Ala Lys Trp
    370                 375                 380                 
Ser Ile Glu Arg His Val Pro Ser Leu Asp Glu His Leu His Tyr Ser
385                 390                 395                 400 
Leu Ile Thr Ser Gly Cys Ser Leu Val Pro Cys Ala Ser Tyr Val Gly
                405                 410                 415     
Met Gly Glu Val Ala Thr Lys Glu Val Phe Asp Trp His Ser Ser Phe
            420                 425                 430         
Pro Lys Ala Val Glu Ala Cys Cys Ala Ile Gly Arg Ile Leu Asn Asp
        435                 440                 445             
Ile Thr Ser Tyr Glu Arg Glu Gln Gly Arg Gly Asp Asn Ala Ser Thr
    450                 455                 460                 
Val Glu Ser Tyr Met Lys Asp His Gly Thr Asn Glu Lys Asp Ala Cys
465                 470                 475                 480 
Lys Lys Leu Gln Glu Ile Val Glu Lys Ala Trp Lys Asp Leu Asn Gln
                485                 490                 495     
Glu Ser Leu Asn Gln Lys Asn Ile Ser Arg Leu Ile Ile Glu Arg Leu
            500                 505                 510         
Val Asn Phe Ser Arg Ser Met Glu Glu Ile Tyr Met Ser Asn Asp Met
        515                 520                 525             
Tyr Thr Asn Ser Gly Thr Lys Met Lys Gly Asn Ile Thr Leu Val Leu
    530                 535                 540                 
Val Glu Ala Phe Pro Val
545                 550 


<210> 519
<211> 548
<212> PRT
<213> Zingiber zerumbet

<220> 
<223> alpha-humulene synthase Acc. No. BAG12020

<400> 519
Met Glu Arg Gln Ser Met Ala Leu Val Gly Asp Lys Glu Glu Ile Ile
 1               5                  10                  15      
Arg Lys Ser Phe Glu Tyr His Pro Thr Val Trp Gly Asp Tyr Phe Ile
            20                  25                  30          
Arg Asn Tyr Ser Cys Leu Pro Leu Glu Lys Glu Cys Met Ile Lys Arg
        35                  40                  45              
Val Glu Glu Leu Lys Asp Arg Val Arg Asn Leu Phe Glu Glu Thr His
    50                  55                  60                  
Asp Val Leu Gln Ile Met Ile Leu Val Asp Ser Ile Gln Leu Leu Gly
65                  70                  75                  80  
Leu Asp Tyr His Phe Glu Lys Glu Ile Thr Ala Ala Leu Arg Leu Ile
                85                  90                  95      
Tyr Glu Ala Asp Val Glu Asn Tyr Gly Leu Tyr Glu Val Ser Leu Arg
            100                 105                 110         
Phe Arg Leu Leu Arg Gln His Gly Tyr Asn Leu Ser Pro Asp Val Phe
        115                 120                 125             
Asn Lys Phe Lys Asp Asp Lys Gly Arg Phe Leu Pro Thr Leu Asn Gly
    130                 135                 140                 
Asp Ala Lys Gly Leu Leu Asn Leu Tyr Asn Ala Ala Tyr Leu Gly Thr
145                 150                 155                 160 
His Glu Glu Thr Ile Leu Asp Glu Ala Ile Ser Phe Thr Lys Cys Gln
                165                 170                 175     
Leu Glu Ser Leu Leu Gly Glu Leu Glu Gln Pro Leu Ala Ile Glu Val
            180                 185                 190         
Ser Leu Phe Leu Glu Thr Pro Leu Tyr Arg Arg Thr Arg Arg Leu Leu
        195                 200                 205             
Val Arg Lys Tyr Ile Pro Ile Tyr Gln Glu Lys Val Met Arg Asn Asp
    210                 215                 220                 
Thr Ile Leu Glu Leu Ala Lys Leu Asp Phe Asn Leu Leu Gln Ser Leu
225                 230                 235                 240 
His Gln Glu Glu Val Lys Lys Ile Thr Ile Trp Trp Asn Asp Leu Ala
                245                 250                 255     
Leu Thr Lys Ser Leu Lys Phe Ala Arg Asp Arg Val Val Glu Cys Tyr
            260                 265                 270         
Tyr Trp Ile Val Ala Val Tyr Phe Glu Pro Gln Tyr Ser Arg Ala Arg
        275                 280                 285             
Val Ile Thr Ser Lys Ala Ile Ser Leu Met Ser Ile Met Asp Asp Ile
    290                 295                 300                 
Tyr Asp Asn Tyr Ser Thr Leu Glu Glu Ser Arg Leu Leu Thr Glu Ala
305                 310                 315                 320 
Ile Glu Arg Trp Glu Pro Gln Ala Val Asp Cys Val Pro Glu Tyr Leu
                325                 330                 335     
Lys Asp Phe Tyr Leu Lys Leu Leu Lys Thr Tyr Lys Asp Phe Glu Asp
            340                 345                 350         
Glu Leu Glu Pro Asn Glu Lys Tyr Arg Ile Pro Tyr Leu Gln Glu Glu
        355                 360                 365             
Ile Lys Val Leu Ser Arg Ala Tyr Phe Gln Glu Ala Lys Trp Gly Val
    370                 375                 380                 
Glu Arg Tyr Val Pro Ala Leu Glu Glu His Leu Leu Val Ser Leu Ile
385                 390                 395                 400 
Thr Ala Gly Tyr Phe Ala Val Ala Cys Ala Ser Tyr Val Gly Leu Gly
                405                 410                 415     
Glu Asp Ala Thr Lys Glu Thr Phe Glu Trp Val Ala Ser Ser Pro Lys
            420                 425                 430         
Ile Leu Lys Ser Cys Ser Ile His Cys Arg Leu Met Asp Asp Ile Thr
        435                 440                 445             
Ser His Gln Arg Glu Gln Glu Arg Asp His Phe Ala Ser Thr Val Glu
    450                 455                 460                 
Ser Tyr Met Lys Glu His Gly Thr Ser Ala Lys Val Ala Cys Glu Lys
465                 470                 475                 480 
Leu Gln Val Met Val Glu Gln Lys Trp Lys Asp Leu Asn Glu Glu Cys
                485                 490                 495     
Leu Arg Pro Thr Gln Val Ala Arg Pro Leu Ile Glu Ile Ile Leu Asn
            500                 505                 510         
Leu Ser Arg Ala Met Glu Asp Ile Tyr Lys His Lys Asp Thr Tyr Thr
        515                 520                 525             
Asn Ser Asn Thr Arg Met Lys Asp Asn Val Ser Leu Ile Phe Val Glu
    530                 535                 540                 
Ser Phe Leu Ile
545             


<210> 520
<211> 554
<212> PRT
<213> Zingiber zerumbet

<220> 
<223> beta-eudesmol synthase Acc. No. BAG12021

<400> 520
Met Glu Lys Gln Ser Leu Thr Phe Asp Gly Asp Glu Glu Ala Lys Ile
 1               5                  10                  15      
Asp Arg Lys Ser Ser Lys Tyr His Pro Ser Ile Trp Gly Asp Tyr Phe
            20                  25                  30          
Ile Gln Asn Ser Ser Leu Thr His Ala Lys Glu Ser Thr Gln Arg Met
        35                  40                  45              
Ile Lys Arg Val Glu Glu Leu Lys Val Gln Val Lys Ser Met Phe Lys
    50                  55                  60                  
Asp Thr Ser Asp Leu Leu Gln Leu Met Asn Leu Ile Asn Ser Ile Gln
65                  70                  75                  80  
Met Leu Gly Leu Asp Tyr His Phe Glu Asn Glu Ile Asp Glu Ala Leu
                85                  90                  95      
Arg Leu Ile Tyr Glu Val Asp Asp Lys Ser Tyr Gly Leu Tyr Glu Thr
            100                 105                 110         
Ser Leu Arg Phe Gln Leu Leu Arg Gln His Gly Tyr His Val Ser Ala
        115                 120                 125             
Asp Ile Phe Asn Lys Phe Lys Asp Asp Asn Gly Ser Phe Ile Ser Ser
    130                 135                 140                 
Leu Asn Gly Asp Ala Lys Gly Leu Leu Ser Leu Tyr Asn Val Ser Tyr
145                 150                 155                 160 
Leu Gly Thr His Gly Glu Thr Ile Leu Asp Glu Ala Lys Ser Phe Thr
                165                 170                 175     
Lys Pro Gln Leu Val Ser Leu Met Ser Glu Leu Glu Gln Ser Leu Ala
            180                 185                 190         
Ala Gln Val Ser Leu Phe Leu Glu Leu Pro Leu Cys Arg Arg Asn Lys
        195                 200                 205             
Ile Leu Leu Ala Arg Lys Tyr Ile Leu Ile Tyr Gln Glu Asp Ala Met
    210                 215                 220                 
Arg Asn Asn Val Ile Leu Glu Leu Ala Lys Leu Asn Phe Asn Leu Leu
225                 230                 235                 240 
Gln Ser Leu Tyr Gln Glu Glu Leu Lys Lys Ile Ser Ile Trp Trp Asn
                245                 250                 255     
Asp Leu Ala Phe Ala Lys Ser Leu Ser Phe Thr Arg Asp Arg Val Val
            260                 265                 270         
Glu Gly Tyr Tyr Trp Val Leu Thr Ile Tyr Phe Glu Pro Gln His Ser
        275                 280                 285             
Arg Ala Arg Val Ile Cys Ser Lys Val Phe Ala Phe Leu Ser Ile Met
    290                 295                 300                 
Asp Asp Ile Tyr Asp Asn Tyr Gly Ile Leu Glu Glu Cys Thr Leu Leu
305                 310                 315                 320 
Thr Glu Ala Ile Lys Arg Trp Asn Pro Gln Ala Ile Asp Gly Leu Pro
                325                 330                 335     
Glu Tyr Leu Lys Asp Tyr Tyr Leu Lys Leu Leu Lys Thr Phe Glu Glu
            340                 345                 350         
Phe Glu Asp Glu Leu Glu Leu Asn Glu Lys Tyr Arg Met Leu Tyr Leu
        355                 360                 365             
Gln Asp Glu Val Lys Ala Leu Ala Ile Ser Tyr Leu Gln Glu Ala Lys
    370                 375                 380                 
Trp Gly Ile Glu Arg His Val Pro Ser Leu Asp Glu His Leu His Asn
385                 390                 395                 400 
Ser Leu Ile Ser Ser Gly Ser Ser Thr Val Ile Cys Ala Ser Phe Val
                405                 410                 415     
Gly Met Gly Glu Val Ala Thr Lys Glu Val Phe Asp Trp Leu Ser Ser
            420                 425                 430         
Phe Pro Lys Val Val Glu Ala Cys Cys Val Ile Gly Arg Leu Leu Asn
        435                 440                 445             
Asp Ile Arg Ser His Glu Leu Glu Gln Gly Arg Asp His Thr Ala Ser
    450                 455                 460                 
Thr Val Glu Ser Tyr Met Lys Glu His Asp Thr Asn Val Asp Val Ala
465                 470                 475                 480 
Cys Glu Lys Leu Arg Glu Ile Val Glu Lys Ala Trp Lys Asp Leu Asn
                485                 490                 495     
Asn Glu Ser Leu Asn Pro Thr Lys Val Pro Arg Leu Met Ile Glu Arg
            500                 505                 510         
Ile Val Asn Leu Ser Lys Ser Asn Glu Glu Ile Tyr Lys Tyr Asn Asp
        515                 520                 525             
Thr Tyr Thr Asn Ser Asp Thr Thr Met Lys Asp Asn Ile Ser Leu Val
    530                 535                 540                 
Leu Val Glu Ser Cys Asp Tyr Phe Asn Lys
545                 550                 


<210> 521
<211> 2607
<212> DNA
<213> Abies grandis

<220> 
<223> abietadiene cyclase

<400> 521
atggccatgc cttcctcttc attgtcatca cagattccca ctgctgctca tcatctaact 60
gctaacgcac aatccattcc gcatttctcc acgacgctga atgctggaag cagtgctagc 120
aaacggagaa gcttgtacct acgatggggt aaaggttcaa acaagatcat tgcctgtgtt 180
ggagaaggtg gtgcaacctc tgttccttat cagtctgctg aaaagaatga ttcgctttct 240
tcttctacat tggtgaaacg agaatttcct ccaggatttt ggaaggatga tcttatcgat 300
tctctaacgt catctcacaa ggttgcagca tcagacgaga agcgtatcga gacattaata 360
tccgagatta agaatatgtt tagatgtatg ggctatggcg aaacgaatcc ctctgcatat 420
gacactgctt gggtagcaag gattccagca gttgatggct ctgacaaccc tcactttcct 480
gagacggttg aatggattct tcaaaatcag ttgaaagatg ggtcttgggg tgaaggattc 540
tacttcttgg catatgacag aatactggct acacttgcat gtattattac ccttaccctc 600
tggcgtactg gggagacaca agtacagaaa ggtattgaat tcttcaggac acaagctgga 660
aagatggaag atgaagctga tagtcatagg ccaagtggat ttgaaatagt atttcctgca 720
atgctaaagg aagctaaaat cttaggcttg gatctgcctt acgatttgcc attcctgaaa 780
caaatcatcg aaaagcggga ggctaagctt aaaaggattc ccactgatgt tctctatgcc 840
cttccaacaa cgttattgta ttctttggaa ggtttacaag aaatagtaga ctggcagaaa 900
ataatgaaac ttcaatccaa ggatggatca tttctcagct ctccggcatc tacagcggct 960
gtattcatgc gtacagggaa caaaaagtgc ttggatttct tgaactttgt cttgaagaaa 1020
ttcggaaacc atgtgccttg tcactatccg cttgatctat ttgaacgttt gtgggcggtt 1080
gatacagttg agcggctagg tatcgatcgt catttcaaag aggagatcaa ggaagcattg 1140
gattatgttt acagccattg ggacgaaaga ggcattggat gggcgagaga gaatcctgtt 1200
cctgatattg atgatacagc catgggcctt cgaatcttga gattacatgg atacaatgta 1260
tcctcagatg ttttaaaaac atttagagat gagaatgggg agttcttttg cttcttgggt 1320
caaacacaga gaggagttac agacatgtta aacgtcaatc gttgttcaca tgtttcattt 1380
ccgggagaaa cgatcatgga agaagcaaaa ctctgtaccg aaaggtatct gaggaatgct 1440
ctggaaaatg tggatgcctt tgacaaatgg gcttttaaaa agaatattcg gggagaggta 1500
gagtatgcac tcaaatatcc ctggcataag agtatgccaa ggttggaggc tagaagctat 1560
attgaaaact atgggccaga tgatgtgtgg cttggaaaaa ctgtatatat gatgccatac 1620
atttcgaatg aaaagtattt agaactagcg aaactggact tcaataaggt gcagtctata 1680
caccaaacag agcttcaaga tcttcgaagg tggtggaaat catccggttt cacggatctg 1740
aatttcactc gtgagcgtgt gacggaaata tatttctcac cggcatcctt tatctttgag 1800
cccgagtttt ctaagtgcag agaggtttat acaaaaactt ccaatttcac tgttatttta 1860
gatgatcttt atgacgccca tggatcttta gacgatctta agttgttcac agaatcagtc 1920
aaaagatggg atctatcact agtggaccaa atgccacaac aaatgaaaat atgttttgtg 1980
ggtttctaca atacttttaa tgatatagca aaagaaggac gtgagaggca agggcgcgat 2040
gtgctaggct acattcaaaa tgtttggaaa gtccaacttg aagcttacac gaaagaagca 2100
gaatggtctg aagctaaata tgtgccatcc ttcaatgaat acatagagaa tgcgagtgtg 2160
tcaatagcat tgggaacagt cgttctcatt agtgctcttt tcactgggga ggttcttaca 2220
gatgaagtac tctccaaaat tgatcgcgaa tctagatttc ttcaactcat gggcttaaca 2280
gggcgtttgg tgaatgacac caaaacttat caggcagaga gaggtcaagg tgaggtggct 2340
tctgccatac aatgttatat gaaggaccat cctaaaatct ctgaagaaga agctctacaa 2400
catgtctata gtgtcatgga aaatgccctc gaagagttga atagggagtt tgtgaataac 2460
aaaataccgg atatttacaa aagactggtt tttgaaactg caagaataat gcaactcttt 2520
tatatgcaag gggatggttt gacactatca catgatatgg aaattaaaga gcatgtcaaa 2580
aattgcctct tccaaccagt tgcctag                                     2607

<210> 522
<211> 2451
<212> DNA
<213> Abies grandis

<220> 
<223> E-alpha-bisabolene synthase

<400> 522
gctggcgttt ctgctgtatc aaaggtttcc agcttggttt gtgatttgtc gagtaccagc 60
ggcttgattc gaagaacggc caatcctcat cccaatgtct ggggttatga tcttgtgcat 120
tctcttaaat caccttatat tgattctagt tacagagaac gcgcggaggt ccttgttagc 180
gagattaaag tgatgcttaa tccagctatt acaggagatg gagaatcaat gattactcca 240
tctgcttatg acacagcatg ggtagcgagg gtgcccgcca ttgatggctc tgctcgcccg 300
caatttcccc aaacagttga ctggattttg aaaaaccagt taaaagatgg ttcatgggga 360
attcagtccc actttctgct gtccgaccgt cttcttgcca ctctttcttg tgttcttgtg 420
ctccttaaat ggaacgttgg ggatctgcaa gtagagcagg gaattgaatt cataaagagc 480
aatctggaac tagtaaagga tgaaaccgat caagatagct tggtaacaga ctttgagatc 540
atatttcctt ctctgttaag agaagctcaa tctctgcgcc tcggacttcc ctacgacctg 600
ccttatatac atctgttgca gactaaacgg caggaaagat tagcaaaact ttcacgggag 660
gaaatctatg cggttccgtc gccattgttg tattctttag agggaataca agatatagtt 720
gaatgggaac gaataatgga agttcaaagt caggatgggt ctttcttaag ctcacctgct 780
tctactgcct gcgttttcat gcacacagga gacgcgaaat gccttgaatt cttgaacagt 840
gtgatgatca agtttggaaa ttttgttccc tgcctgtatc ctgtggatct gctggaacgc 900
ctgttgatcg tagataatat tgtacgcctt ggaatctata gacactttga aaaggaaatc 960
aaggaagctc ttgattatgt ttacaggcat tggaacgaaa gaggaattgg gtggggcaga 1020
ctaaatccca tagcagatct tgagaccact gctttgggat ttcgattgct tcggctgcat 1080
aggtacaatg tatctccagc catttttgac aacttcaaag atgccaatgg gaaattcatt 1140
tgctcgaccg gtcaattcaa caaagatgta gcaagcatgc tgaatcttta tagagcttcc 1200
cagctcgcat ttcccggaga aaacattctt gatgaagcta aaagcttcgc tactaaatat 1260
ttgagagaag ctcttgagaa aagtgagact tccagtgcat ggaacaacaa acaaaacctg 1320
agccaagaga tcaaatacgc gctgaagact tcttggcatg ccagtgttcc gagagtggaa 1380
gcaaagagat actgtcaagt gtatcgccca gattatgcac gcatagcaaa atgcgtttac 1440
aagctaccct acgtgaacaa tgaaaagttt ttagagctgg gaaaattaga tttcaacatt 1500
atccagtcca tccaccagga agaaatgaag aatgttacca gctggtttag agattcgggg 1560
ttgccactat tcaccttcgc tcgggagagg ccgctggaat tctacttctt agtagcggcg 1620
gggacctatg aaccccagta tgccaaatgc aggtttctct ttacaaaagt ggcatgcttg 1680
cagactgttc tggacgatat gtatgacact tatggaaccc tagatgaatt gaagctattc 1740
actgaagctg tgagaagatg ggacgtctcc tttacagaaa accttccaga ctatatgaaa 1800
ctatgttacc aaatctatta tgacatagtt cacgaggtgg cttgggaggc agagaaggaa 1860
caggggcgtg aattggtcag ctttttcaga aagggatggg aggattatct tctgggttat 1920
tatgaagaag ctgaatggtt agctgctgag tatgtgccta gcttggacga gtacataaag 1980
aatggaatca catctatcgg ccaacgtata cttctgctga gtggagtgtt gataatggat 2040
gggcaactcc tttcgcaaga ggcattagag aaagtagatt atccaggaag acgtgttctc 2100
acagagctga atagcctcat ttcccgcctg gcggatgaca cgaagacata taaagctgag 2160
aaggctcgtg gagaattggc gtccagcatt gaatgttaca tgaaagacca tcctgaatgt 2220
acagaggaag aggctctcga tcacatctat agcattctgg agccggcggt gaaggaactg 2280
acgagagagt ttctgaagcc cgacgacgtc ccattcgctt gcaagaagat gcttttcgag 2340
gagacgggag tgactatggt gatattcaag gatggagatg gattcggtgt ttccaaatta 2400
gaagtcaaag atcatatcaa agagtgtctc attgaaccgc tgccactgta a          2451

<210> 523
<211> 2018
<212> DNA
<213> Abies grandis

<220> 
<223> pinene synthase

<400> 523
cagcaatggc tctagtttct accgcaccgt tggcttccaa atcatgcctg cacaaatcgt 60
tgatcagttc tacccatgag cttaaggctc tctctagaac aattccagct ctaggaatga 120
gtaggcgagg gaaatctatc actccttcca tcagcatgag ctctaccacc gttgtaaccg 180
atgatggtgt acgaagacgc atgggcgatt tccattccaa cctctgggac gatgatgtca 240
tacagtcttt accaacggct tatgaggaaa aatcgtacct ggagcgtgct gagaaactga 300
tcggggaagt aaagaacatg ttcaattcga tgtcattaga agatggagag ttaatgagtc 360
cgctcaatga tctcattcaa cgcctttgga ttgtcgacag ccttgaacgt ttggggatcc 420
atagacattt caaagatgag ataaaatcgg cgcttgatta tgtttacagt tattggggcg 480
aaaatggcat cggatgcggg agggagagtg ttgttactga tctgaactca actgcgttgg 540
ggcttcgaac cctacgacta cacggatacc cggtgtcttc agatgttttc aaagctttca 600
aaggccaaaa tgggcagttt tcctgctctg aaaatattca gacagatgaa gagatcagag 660
gcgttctgaa tttattccgg gcctccctca ttgcctttcc aggggagaaa attatggatg 720
aggctgaaat cttctctacc aaatatttaa aagaagccct gcaaaagatt ccggtctcca 780
gtctttcgcg agagatcggg gacgttttgg aatatggttg gcacacatat ttgccgcgat 840
tggaagcaag gaattacatc caagtctttg gacaggacac tgagaacacg aagtcatatg 900
tgaagagcaa aaaactttta gaactcgcaa aattggagtt caacatcttt caatccttac 960
aaaagaggga gttagaaagt ctggtcagat ggtggaaaga atcgggtttt cctgagatga 1020
ccttctgccg acatcgtcac gtggaatact acactttggc ttcctgcatt gcgttcgagc 1080
ctcaacattc tggattcaga ctcggctttg ccaagacgtg tcatcttatc acggttcttg 1140
acgatatgta cgacaccttc ggcacagtag acgagctgga actcttcaca gcgacaatga 1200
agagatggga tccgtcctcg atagattgcc ttccagaata tatgaaagga gtgtacatag 1260
cggtttacga caccgtaaat gaaatggctc gagaggcaga ggaggctcaa ggccgagata 1320
cgctcacata tgctcgggaa gcttgggagg cttatattga ttcgtatatg caagaagcaa 1380
ggtggatcgc cactggttac ctgccctcct ttgatgagta ctacgagaat gggaaagtta 1440
gctgtggtca tcgcatatcc gcattgcaac ccattctgac aatggacatc ccctttcctg 1500
atcatatcct caaggaagtt gacttcccat caaagcttaa cgacttggca tgtgccatcc 1560
ttcgattacg aggtgatacg cggtgctaca aggcggacag ggctcgtgga gaagaagctt 1620
cctctatatc atgttatatg aaagacaatc ctggagtatc agaggaagat gctctcgatc 1680
atatcaacgc catgatcagt gacgtaatca aaggattaaa ttgggaactt ctcaaaccag 1740
acatcaatgt tcccatctcg gcgaagaaac atgcttttga catcgccaga gctttccatt 1800
acggctacaa ataccgagac ggctacagcg ttgccaacgt tgaaacgaag agtttggtca 1860
cgagaaccct ccttgaatct gtgcctttgt agcaacagct caaatctatg ccctatgcta 1920
tgtcgggtta aaatatatgt ggaaggtagc cgttggatgt agaggataag tttgttataa 1980
tttaataaag ttgtaattta aaaaaaaaaa aaaaaaaa                         2018

<210> 524
<211> 1785
<212> DNA
<213> Abies grandis

<220> 
<223> gamma-humulene synthase

<400> 524
tccatggctc agatttctga atctgtatca ccctctaccg atttgaagag caccgaatct 60
tccattacct ctaatcgaca tggaaatatg tgggaggacg atcgcataca gtctctcaac 120
tcaccttatg gggcacctgc atatcaagaa cgcagcgaaa agcttattga agagatcaaa 180
cttttatttt tgagtgacat ggacgatagc tgcaatgata gcgatcgtga tttaatcaaa 240
cgtcttgaga tcgttgatac tgtcgagtgt ctgggaattg atcgacattt tcaacctgag 300
ataaaattag ctctggatta cgtttacaga tgttggaacg aaagaggcat cggagaggga 360
tcaagagatt ccctcaagaa agatctgaac gctacagctt tgggattccg ggctctccga 420
ctccatcgat ataacgtatc ctcaggtgtc ttggagaatt tcagagatga taacgggcag 480
ttcttctgcg gttctacagt tgaagaagaa ggagcagaag catataataa acacgtaaga 540
tgcatgctgt cattatcgcg agcttcaaac attttatttc cgggcgaaaa agtgatggaa 600
gaggcgaagg cattcacaac aaattatcta aagaaagttt tagcaggacg ggaggctacc 660
cacgtcgatg aaagcctttt gggagaggtg aagtacgcat tggagtttcc atggcattgc 720
agtgtgcaga gatgggaggc aaggagcttt atcgaaatat ttggacaaat tgattcagag 780
cttaagtcga atttgagcaa aaaaatgtta gagttggcga aattggactt caatattctg 840
caatgcacac atcagaaaga actgcagatt atctcaaggt ggttcgcaga ctcaagtata 900
gcatccctga atttctatcg gaaatgttac gtcgaatttt acttttggat ggctgcagcc 960
atctccgagc cggagttttc tggaagcaga gttgccttca caaaaattgc tatactgatg 1020
acaatgctag atgacctgta cgatactcac ggaaccttgg accaactcaa aatctttaca 1080
gagggagtga gacgatggga tgtttcgttg gtagagggcc tcccagactt catgaaaatt 1140
gcattcgagt tctggttaaa gacatctaat gaattgattg ctgaagctgt taaagcgcaa 1200
gggcaagata tggcggccta cataagaaaa aatgcatggg agcgatacct tgaagcttat 1260
ctgcaagatg cggaatggat agccactgga catgtcccca cctttgatga gtacttgaat 1320
aatggcacac caaacactgg gatgtgtgta ttgaatttga ttccgcttct gttaatgggt 1380
gaacatttac caatcgacat tctggagcaa atattcttgc cctccaggtt ccaccatctc 1440
attgaattgg cttccaggct cgtcgatgac gcgagagatt tccaggcgga gaaggatcat 1500
ggggatttat cgtgtattga gtgttattta aaagatcatc ctgagtctac agtagaagat 1560
gctttaaatc atgttaatgg cctccttggc aattgccttc tggaaatgaa ttggaagttc 1620
ttaaagaagc aggacagtgt gccactctcg tgtaagaagt acagcttcca tgtattggca 1680
cgaagcatcc aattcatgta caatcaaggc gatggcttct ccatttcgaa caaagtgatc 1740
aaggatcaag tgcagaaagt tcttattgtc cccgtgccta tttga                 1785

<210> 525
<211> 1865
<212> DNA
<213> Abies grandis

<220> 
<223> delta-selinene synthase

<400> 525
atggctgaga tttctgaatc ttccatccct cgacgcacag ggaatcatca cggaaatgtg 60
tgggacgatg acctcataca ctctctcaac tcgccctatg gggcacctgc atattatgag 120
ctccttcaaa agcttattca ggagatcaag catttacttt tgactgaaat ggaaatggat 180
gatggcgatc atgatttaat caaacgtctt cagatcgttg acactttgga atgcctggga 240
atcgatagac attttgaaca cgaaatacaa acagctgctt tagattacgt ttacagatgg 300
tggaacgaaa aaggtatcgg ggagggatca agagattcct tcagcaaaga tctgaacgct 360
acggctttag gatttcgcgc tctccgactg catcgatata acgtatcgtc aggtgtgttg 420
aagaatttca aggatgaaaa cgggaagttc ttctgcaact ttactggtga agaaggaaga 480
ggagataaac aagtgagaag catgttgtcg ttacttcgag cttcagagat ttcgtttccc 540
ggagaaaaag tgatggaaga ggccaaggca ttcacaagag aatatctaaa ccaagtttta 600
gctggacacg gggatgtgac tgacgtggat caaagccttt tgagagaggt gaagtacgca 660
ttggagtttc catggcattg cagtgtgccg agatgggagg caaggagctt tctcgaaata 720
tatggacaca accattcgtg gctcaagtcg aatatcaacc aaaaaatgtt gaagttagcc 780
aaattggact tcaatattct gcaatgcaaa catcacaagg agatacagtt tattacaagg 840
tggtggagag actcgggtat atcgcagctg aatttctatc gaaagcgaca cgtggaatat 900
tattcttggg ttgttatgtg catttttgag ccagagttct ctgaaagtag aattgccttc 960
gccaaaactg ctatcctgtg tactgttcta gatgacctct atgatacgca cgcaacattg 1020
catgaaatca aaatcatgac agagggagtg agacgatggg atctttcgtt gacagatgac 1080
ctcccagact acattaaaat tgcattccag ttcttcttca atacagtgaa tgaattgata 1140
gttgaaatcg tgaaacggca agggcgggat atgacaacca tagttaaaga ttgctggaag 1200
cgatacattg agtcttatct gcaagaagcg gaatggatag caactggaca tattcccact 1260
tttaacgaat acataaagaa cggcatggct agctcaggga tgtgtattct aaatttgaat 1320
ccacttctct tgttggataa acttctcccc gacaacattc tggagcaaat acattctcca 1380
tccaagatcc tggacctctt agaattgacg ggcagaatcg ccgatgactt aaaagatttc 1440
gaggacgaga aggaacgcgg ggagatggct tcatctttac agtgttatat gaaagaaaat 1500
cctgaatcta cagtggaaaa tgctttaaat cacataaaag gcatccttaa tcgttccctt 1560
gaggaattta attgggagtt tatgaagcag gatagtgtcc caatgtgttg caagaaattc 1620
actttcaata taggtcgagg acttcaattc atctacaaat acagagacgg cttatacatt 1680
tctgacaagg aagtaaagga ccagatattc aaaattctag tccaccaagt tccaatggag 1740
gaatagtgat ggtcttggtt gtagttgtct attatggtat attgcattga catttatgct 1800
taaaggtgtt tcttaaacgt ttagggcgga ccgttaaata agttggcaat aattaatatc 1860
tcgag                                                             1865

<210> 526
<211> 2007
<212> DNA
<213> Actinidia deliciosa

<220> 
<223> germacrene-D synthase

<400> 526
gtgaaaacta aaataggcca agtgtgtagg ttcatctcta gtttttctct ttaaattaat 60
tcttcaaccc agaaaaaaaa catgcaacta ccttgtgctc aagctttgcc aataccaact 120
gttacaacca ccactagtat tgaaccacca catgtaacgc gtcgctctgc aaattatcat 180
cctagcattt ggggagatca tttcctcgcc tactcttccg atgctatgga agaagaggtt 240
attaacatgg aacaacaaca acgacttcat cacctgaaac aaaaggtgag aaaaatgcta 300
gaggcagctg ctgaacaatc ttcacagatg ctgaacctcg tcgacaaaat ccaacgctta 360
ggcgtgtctt accattttga aactgagatc gaaacagctt tacggcacat atacaaaacc 420
tgtgattacc attttgatga tctccacact gctgctctct cttttcggtt acttagacaa 480
caaggatatc cagtttcttg tgatatgttc gacaaattca agaacagcaa aggtgagttt 540
caagaatcca taatcagcga tgtgcaagga atgttaagtt tgtatgaagc tacatgtcta 600
aggatacacg gagaagatat actagacgaa gcactagctt ttaccatcac tcaacttcgg 660
tccgcattgc ccaacttaag cactcctttc aaggaacaaa tcattcatgc tctgaaccag 720
cccatccaca aggggttgac aaggctcaac gcaaggagcc acattttatt ttttgaacag 780
aatgattgcc atagcaaaga ccttttgaat ttcgcaaaat tagatttcaa cttattacaa 840
aagttgcacc agagggagct atgtgaaatc acaaggtggt ggaaagattt gaattttgca 900
aagacactac cttttgccag agacagaatg gtagagtgct acttttggat acttggggtg 960
tactttgagc cccaatatct gcttgctagg aggatgctaa ccaaggtgat tgccatgatt 1020
tccattatcg atgacatcta cgatgtctac ggtaccttgg aagaacttgt tctcttcact 1080
gatgcaattg agaggtggga gatcagtgcc ttggatcaac ttccagagta tatgaaacta 1140
tgttatcaag cacttttgga tgtttatagt atgattgatg aagagatggc gaagcaagga 1200
agatcttatt gcgtagacta tgcaaaatct tcaatgaaaa ttttggttag agcatacttc 1260
gaagaagcca aatggtttca ccaaggatat gttccaacta tggaagagta tatgcaagtt 1320
gcattagtaa ccgcgggtta caaaatgctt gcaacctctt cctttgttgg catgggagat 1380
ttggcaacca aagaggcctt tgattgggtg tcaaatgatc ctttaattgt tcaagctgca 1440
tcagtgatag gcagactcaa ggatgacatt gttggccaca agtttgagca aaagagaggg 1500
cacgtggcgt cggctgtcga atgctacagt aagcaacatg gtacaacaga ggaagaggct 1560
attattgaat tggataaaca agttacacat tcatggaaag acatcaacgc agagtgcctc 1620
tgcccaatca aggtcccaat gcctcttctt gcgcgagttc tcaatcttgc acgagtgctt 1680
tatgttatat accaggatga agacggatac actcatcctg gaaccaaggt cgagaacttt 1740
gtaacctcag tgcttatcga ttctatgcca atcaattaga aaatgtaaca agacactgaa 1800
gtggaggcat aaataaattc aaaagttgat ttaaagttgg ggtagtgaac ggggattctt 1860
accattaaga gatattcttg ctaaaaagca attaattcaa tgcatttcca ataaaataat 1920
ttagccagtt gttcttcatc ttgttttttt tttgtttctc tttcctttct aaatataaaa 1980
ttataattaa ttggcaaaaa aaaaaaa                                     2007

<210> 527
<211> 1885
<212> DNA
<213> Antirrhinum majus

<220> 
<223> (3S)-(E)-nerolidol synthase

<400> 527
tcttcatcat atttaagcat tttatattgg caacaacttg tcaggtgtac cccacgcttg 60
ttcactaaat accaatatta ctaaatttgc aaaattcgga aatatgagta accttcatgt 120
aaagaaaact gatcgaatcg cctcaggttt tgatgttgca tatttgtctg ctgctaataa 180
gacacatcaa tggagcattg ctgatgatat tgcatcaact cctggctccc ccagactcca 240
ttaccctatg gacttcaatg gacaaagtac acgtactccg gataattttt caatggaata 300
tgataaaaaa attgaagaaa taaagaactt gttacggtca aaacgtgaag aagaaccaat 360
tgatagattg atgttcgtgg atgccatcca gagactaggc gtcaaccaca attttgagga 420
gttgattgaa acaattctcc gaaactatta tgaatcaaca agtgctaata tatgcggatt 480
ccacactttg cacgacgttt ccctattttt tcgtctaatg agacaacatg gatacgacat 540
ttcttcagat gtatttaaca aattcaaagg cgatgatggg aggttccgag gtgaattaca 600
acgagataca cgaggattga tggaattata tgaagcttca caactaagat ttgagggaga 660
atatacactt gatgaagcag agagctttag cagccagaat ctcaataaat acttggccga 720
tatggactgc agctcgtgta gactcgttac taacaaactg cagcaccctt atcgaaagag 780
cataggaaga ttgacaacaa ggtatgattt tagaggcaag aaccaatggg gaaaaacatt 840
gcacgagctt gctgcaatgg atttgcgcat gaggaaatcc gaataccaaa aggagttatt 900
ccaagtttct gagtggtgga aggaactaag gatagctgag aatctgagtc tcgcaagaaa 960
ccaaccattg aaatggtata catgttcgat ggccattctc atagatgata taactttatc 1020
ggagcaaaga atcgagctca ccaaatccat cactttcatt tacttgatag atgatatttt 1080
tgatgtttat gggtcaccag aggagctcgt tatttttgca gaagccgtaa gcaaatggga 1140
ctatgctgct gtcgaaacgt tgccagatta catgaaactg tgttacaagt ctcttcttga 1200
taccacaaac gagataggat acaaaattta tgagaagtat ggatataatc caattgactc 1260
cctcaaaaca acgtgggcaa gtttgtgcaa tgcattccta gaggaagcta aatggtttgc 1320
ctcggggaac ctgccaaacg ctacgaagta tttggaaaat ggcaaggtga gttcaggagt 1380
gtatgtggtg atggtccatt tgttctttct tttgggactc ggcggaacat gtggaagtgc 1440
aatccattta aacgacacat caaaacttat gtcctctgta gccacaatcc ttcggctgtg 1500
ggatgatttg ggaagtgcta aggatgagca tcaagatggt aaagatggat cttacataga 1560
atgctacatg aaagaacata taagcttgtc gactgagcaa gcacaacaac acgccattga 1620
tttgatatcg agcgagtgga aactccttaa caaagaatgt ttcaatctta atcatgtttc 1680
gacatcatct atcaaaaagg cggctcttaa tactgcgaga atggttcctc ttatgtatag 1740
ctacgatgag aatcaagggc tgccaatcct ggaggagtat gttaagatta tgttgtttga 1800
ttagacatcg tcgaagcact accaattaaa gaacaactag tttggttgta ccatacttat 1860
taaacaactt ttccaatagt aaaaa                                       1885

<210> 528
<211> 1644
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> (-)-E-beta-caryophylene synthase

<400> 528
atggggagtg aagtcaaccg tccactagct gattttccag caaatatctg ggaagatcca 60
ttaacttctt tctcaaagtc tgacctcgga actgagacgt tcaaagagaa gcatagtacg 120
ctaaaggagg cggtgaagga agcttttatg tcttccaaag cgaatccgat agagaacatc 180
aaattcatcg atgctctatg tcgccttggt gtctcctgtc actttgagaa agatatcgta 240
gaacaattgg ataagtcatt tgattgtctt gattttcctc agatggtaag acaagaggga 300
tgcgatttgt acacggttgg aataattttc caagttttca ggcaattcgg ctttaaactt 360
tctgccgatg tgtttgagaa gttcaaggac gaaaatggga agttcaaagg acacttggtg 420
acagatgcat acgggatgtt aagtttgtac gaagctgcac aatggggcac tcacggagag 480
gacattattg acgaagctct cgctttctca cgttctcatt tagaagaaat ttcgtctcgg 540
tctagccctc atctcgcaat tcgcatcaag aatgctctaa aacatccata ccataaaggc 600
atctctagga tagaaacaag acaatatatc tcatactacg aggaggaaga gtcgtgcgac 660
ccaacattac ttgagttcgc aaagatagat tttaatttgc tgcaaatatt acaccgcgaa 720
gagcttgctt gcgtcacaag gtggcaccat gaaatggagt ttaaatctaa agtaacatac 780
acaaggcata ggataacaga ggcatacttg tggtcacttg gaacatattt cgagcctcaa 840
tattctcaag cacgagttat aaccactatg gcactaatct tattcacagc gcttgatgat 900
atgtatgatg catatggcac aatggaggaa cttgagcttt tcactgatgc aatggatgag 960
tggcttcccg ttgttcctga tgagataccg atacccgata gcatgaagtt catttacaat 1020
gtgacggtag aattctatga taaactcgac gaggaacttg agaaggaagg aaggtcaggg 1080
tgcggtttcc atcttaagaa atcattgcaa aaaacagcaa atggatatat gcaagaagca 1140
aaatggttga aaaaggatta cattgctaca tttgatgagt ataaagagaa tgcaatcttg 1200
tcttcaggtt attatggctt gatagcgatg acattcgtga gaatgacaga tgtcgcaaaa 1260
cttgatgctt ttgaatggtt aaactcacat cctaaaatta gggtagcttc tgagataata 1320
agtcgattca cagatgacat ttcaagctac gaatttgaac acaaacggga gcatgtagcg 1380
actggcattg attgttatat gcagcaattt ggtgtttcca aggaaagagc tgtggaagtg 1440
atgggaaaca ttgtttcaga tgcatggaag gacttgaacc aagagctaat gaggcctcac 1500
gtgtttcctt tccctctttt gatgcgagtt cttaaccttt cgcgagtcat cgatgtattc 1560
tataggtacc aagatgctta caccaacccc aagctcttga aggagcacat tgtttctttg 1620
ctcattgaaa ctatacccat ttga                                        1644

<210> 529
<211> 1786
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> (E)-beta-ocimene synthase/ myrcene synthase

<400> 529
aaatcagtat aaaatatcat agcggagtct aaagaagagt tcatccaatt atttaactct 60
ttagtgtaat cattagcaac gcaaagaaat gcctaaacga caggctcaac ggcgtttcac 120
tcgcaagact gactcgaaaa caccatccca gcctctggta tcccgtcgct ctgcaaacta 180
tcaaccgtct ctttggcagc acgaatatct cctctcgctc ggtaatacat atgtgaaaga 240
ggacaacgtc gagagagtta cgttattgaa gcaggaagtg agtaaaatgc tcaatgaaac 300
ggaaggttta ctcgaacagc tagagctcat cgacacttta caaaggcttg gagtttctta 360
ccattttgaa caagaaatca agaagacact aacgaatgtg catgttaaaa atgtgcgagc 420
acacaaaaac cggatagatc gaaaccgatg gggagattta tacgcgaccg cccttgagtt 480
ccgactccta aggcaacatg gtttcagtat cgcacaagat gtttttgacg gaaatattgg 540
agttgatttg gatgataaag acatcaaggg tattctttca ctatacgaag cttcatatct 600
ctcgaccaga atcgatacta aattgaaaga gagcatatac tatacaacaa aacgacttag 660
aaaatttgtg gaggtaaata agaatgagac caaatcttac actcttcgaa ggatggttat 720
acatgcgtta gagatgccgt accaccggag agtgggaaga ctagaagcaa gatggtacat 780
agaagtgtac ggagagagac acgacatgaa ccctatcttg cttgaactcg cgaaacttga 840
ttttaatttc gtacaagcta tccatcaaga cgagctcaaa tccctctcta gttggtggag 900
caagacggga ttaacaaaac acctcgattt cgttagagat cgaataacgg agggttattt 960
ctcgagtgtt ggagtaatgt atgagcccga gtttgcatat caccgacaaa tgcttacaaa 1020
ggttttcatg ctcattacaa ctatcgacga tatatacgat atttatggga cacttgagga 1080
gctccaacta ttcacgacca tagttgaaaa atgggatgtg aatcgtcttg aagaacttcc 1140
caactacatg aagttatgtt ttctctgcct cgtcaacgaa atcaatcaga ttggatattt 1200
tgtactcaga gataaagggt ttaatgtgat tccttacctc aaagaatctt gggcagatat 1260
gtgtacaacg tttttgaaag aggcaaagtg gtataaaagt ggttacaaac ctaacttcga 1320
agaatacatg caaaatggtt ggatctcaag ctcagtccct acaatacttc tacacttgtt 1380
ctgtctctta tccgaccaaa ccttagacat tcttggctcc tacaatcact ctgtagttcg 1440
aagctccgcc accatcctcc gtctcgctaa cgatctcgcc acttcttcgg aggaattagc 1500
gagaggcgac actatgaaat ccgtacaatg tcacatgcat gaaactggag cttcggaggc 1560
agagtcacgc gcgtacattc aaggaattat cggtgtggct tgggatgact taaacatgga 1620
gaaaaagagt tgtaggctac atcaaggttt cctagaagct gcggctaatc ttggacgtgt 1680
ggctcagtgc gtttatcagt acggtgatgg ccatggctgt cctgacaagg ctaagaccgt 1740
caatcatgtc cggtccttgc tcgtccaccc tcttccactc aattaa                1786

<210> 530
<211> 1622
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> (Z)-gamma-bisabolene synthase

<400> 530
atggaatccc aaacaacgtt taagtatgaa agtcttgcgt tcacaaagtt gtctcactgt 60
caatggactg attacttcct ctctgttccc atcgatgaat cggaactaga tgttattaca 120
agagagattg acatactcaa gccggaagtt atggagctcc tatcttccca gggtgacgat 180
gagacatcga agaggaaagt gcttttgatt caattgcttc ttagtcttgg tctcgcattt 240
cattttgaaa atgagatcaa aaatatacta gaacatgctt ttcgaaagat agatgatata 300
actggtgatg aaaaggactt gtctacaatc tccatcatgt tccgtgtctt tagaacatac 360
ggacacaatt taccatcaag tgtattcaag agatttacag gggatgatgg gaagtttcag 420
caatctctta cggaagatgc taaaggaata cttagcttgt atgaagcggc acacttggga 480
acaacgacag attatatatt ggacgaagcg ttgaagttta catcgagcca cttgaagtct 540
ttattggcag gagggacgtg ccggcctcat atcttaaggc ttataagaaa cacactttat 600
ttacctcaac gttggaatat ggaagcagta attgcaaggg aatacatttc gttctatgaa 660
caagaagaag atcacgataa gatgctactc agattagcca agctcaattt caagttattg 720
cagctgcatt acattaaaga actgaaatct tttatcaaat ggtggatgga gctaggcctt 780
acatctaagt ggcctagtca atttagagag aggatcgtgg aggcttggct agctggattg 840
atgatgtatt tcgaaccaca attttcgggt ggaagggtta ttgcagctaa gtttaactac 900
ctccttacca ttttagatga cgcgtgcgat cattatttct ctattcatga gcttacaaga 960
ctcgtagctt gtgtggaaag atggagtcct gatggcattg acacacttga agatatatcg 1020
cgaagtgtct ttaaacttat gttggatgtt ttcgacgata tcggaaaagg agtgaggtct 1080
gaaggaagct cctaccactt gaaggagatg ttagaagagc tcaatacact cgtgagagca 1140
aatcttgatc ttgtcaaatg ggcacgagga attcagactg ccgggaagga agcttacgag 1200
tgggtaagat cgagaccaag actaatcaaa tctctagctg caaagggccg tctaatggac 1260
gatattactg attttgacag cgacatgagt aatgggtttg ctgcaaatgc gatcaactat 1320
tatatgaagc aatttgtagt taccaaggaa gaggctattc tcgagtgtca aagaatgatc 1380
gtggacatca ataagaccat aaatgaggag ctactgaaga caaccagcgt accaggtcga 1440
gtactcaagc aagcacttaa ttttggacgc ttattggaac tcctctacac caagtccgat 1500
gatatataca attgtagtga aggaaaactg aaggagtata tagtaactct gctcatagat 1560
cccatacgtc tttgaagact tcgaattaca tggtttattg agtggtttat tcatgtctac 1620
aa                                                                1622

<210> 531
<211> 1665
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> (Z)-gamma-bisabolene synthase

<400> 531
atggaatccc aaacaaagtt cgattatgaa agtcttgcgt tcacaaagtt gtctcactct 60
caatggactg attacttcct ctctgttccc atcgatgatt cggagttaga cgctattaca 120
agagagattg acataatcaa gcctgaagtt aggaagctcc tatcttccaa aggtgatgat 180
gagacatcaa agaggaaagt gcttttgatc caatcgcttc ttagccttgg cctcgcattt 240
cattttgaaa atgaaatcaa agatatatta gaagatgctt ttcgaaggat agatgatata 300
actggtgatg aaaatgactt gtctacaatc tccatcatgt tccgcgtttt cagaacatac 360
ggacacaatt taccatcaag tgtattcaag agatttacag gggatgatgg gaagtttgag 420
cgatctctca cggaagatgc taaaggaata cttagcttgt atgaagcggc acacttggga 480
acaacgacag attatatatt ggacgaagcg ttggagttta catcgagcca cttgaagtct 540
ttattggtag gcgggatgtg ccggcctcat atcttaaggc ttataagaaa cacactttat 600
ttacctcaac gttggaacat ggaagcagta attgcaaggg aatacatttc gttctacgaa 660
caagaagaag atcacgataa gatgctactc agattagcta agctcaattt caagttattg 720
cagctgcatt acatcaaaga actgaaaact tttatcaaat ggtggatgga gctaggcctt 780
acatctaagt ggccaagtca atttagagag aggatcgtgg aggcttggct agctggattg 840
atgatgtatt tcgaaccaca attttctggt ggaagggtta ttgcagctaa gtttaactac 900
ctccttacca ttttagatga cgcttgcgat cactatttct ctattcctga gcttacaagg 960
ctcgtagatt gtgtggaaag atggaatcat gatggcattc acacactaga agatatatcg 1020
cgaattatct tcaaacttgc gttggatgtt ttcgacgata tcggaagagg agtgaggtct 1080
aaaggatgtt cctactactt gaaggagatg ttagaagagc tcaagatact tgtgagagca 1140
aaccttgatc ttgtcaaatg ggcacgagga aatcagctgc ctagcttcga agaacatgta 1200
gaggttggtg ggatagcact taccacatat gcaacgttaa tgtactcttt tgttggaatg 1260
ggagaggctg tcgggaagga agcttatgag tgggtaagat cgagaccaag actaatcaaa 1320
tctctagctg caaagggtcg tctgatggac gatataactg atttcgagag cgacatgagt 1380
aatgggtttg ctgcaaatgc gatcaactat tatatgaagc aattcgtagt taccaaagaa 1440
gaagctattc tagagtgtca aaaaatggtc gtagacatca ataagatagt aaatgaggag 1500
ctactaaaaa caaccaccgt gccacgtcga gttctcaagc aagccctcaa ttttggacgc 1560
ttattggaag tcctctacac caagtccgat gatatataca attgtagtga aggaaaattg 1620
aaggagtata tagtcacctt actcatagat cccatacatc tttga                 1665

<210> 532
<211> 2570
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> GA1 ent-copalyl diphosphate synthase

<400> 532
cttcttcact aaatacttag acagagaaaa cagagctttt taaagccatg tctcttcagt 60
atcatgttct aaactccatt ccaagtacaa cctttctcag ttctactaaa acaacaatat 120
cttcttcttt ccttaccatc tcaggatctc ctctcaatgt cgctagagac aaatccagaa 180
gcggttccat acattgttca aagcttcgaa ctcaagaata cattaattct caagaggttc 240
aacatgattt gcctctaata catgagtggc aacagcttca aggagaagat gctcctcaga 300
ttagtgttgg aagtaatagt aatgcattca aagaagcagt gaagagtgtg aaaacgatct 360
tgagaaacct aacggacggg gaaattacga tatcggctta cgatacagct tgggttgcat 420
tgatcgatgc cggagataaa actccggcgt ttccctccgc cgtgaaatgg atcgccgaga 480
accaactttc cgatggttct tggggagatg cgtatctctt ctcttatcat gatcgtctca 540
tcaataccct tgcatgcgtc gttgctctaa gatcatggaa tctctttcct catcaatgca 600
acaaaggaat cacgtttttc cgggaaaata ttgggaagct agaagacgaa aatgatgagc 660
atatgccaat cggattcgaa gtagcattcc catcgttgct tgagatagct cgaggaataa 720
acattgatgt accgtacgat tctccggtct taaaagatat atacgccaag aaagagctaa 780
agcttacaag gataccaaaa gagataatgc acaagatacc aacaacattg ttgcatagtt 840
tggaggggat gcgtgattta gattgggaaa agctcttgaa acttcaatct caagacggat 900
ctttcctctt ctctccttcc tctaccgctt ttgcattcat gcagacccga gacagtaact 960
gcctcgagta tttgcgaaat gccgtcaaac gtttcaatgg aggagttccc aatgtctttc 1020
ccgtggatct tttcgagcac atatggatag tggatcggtt acaacgttta gggatatcga 1080
gatactttga agaagagatt aaagagtgtc ttgactatgt ccacagatat tggaccgaca 1140
atggcatatg ttgggctaga tgttcccatg tccaagacat cgatgataca gccatggcat 1200
ttaggctctt aagacaacat ggataccaag tgtccgcaga tgtattcaag aactttgaga 1260
aagagggaga gtttttctgc tttgtggggc aatcaaacca agcagtaacc ggtatgttca 1320
acctataccg ggcatcacaa ttggcgtttc caagggaaga gatattgaaa aacgccaaag 1380
agttttctta taattatctg ctagaaaaac gggagagaga ggagttgatt gataagtgga 1440
ttataatgaa agacttacct ggcgagattg ggtttgcgtt agagattcca tggtacgcaa 1500
gcttgcctcg agtagagacg agattctata ttgatcaata tggtggagaa aacgacgttt 1560
ggattggcaa gactctttat aggatgccat acgtgaacaa taatggatat ctggaattag 1620
caaaacaaga ttacaacaat tgccaagctc agcatcagct cgaatgggac atattccaaa 1680
agtggtatga agaaaatagg ttaagtgagt ggggtgtgcg cagaagtgag cttctcgagt 1740
gttactactt agcggctgca actatatttg aatcagaaag gtcacatgag agaatggttt 1800
gggctaagtc aagtgtattg gttaaagcca tttcttcttc ttttggggaa tcctctgact 1860
ccagaagaag cttctccgat cagtttcatg aatacattgc caatgctcga cgaagtgatc 1920
atcactttaa tgacaggaac atgagattgg accgaccagg atcggttcag gccagtcggc 1980
ttgccggagt gttaatcggg actttgaatc aaatgtcttt tgaccttttc atgtctcatg 2040
gccgtgacgt taacaatctc ctctatctat cgtggggaga ttggatggaa aaatggaaac 2100
tatatggaga tgaaggagaa ggagagctca tggtgaagat gataattcta atgaagaaca 2160
atgacctaac taacttcttc acccacactc acttcgttcg tctcgcggaa atcatcaatc 2220
gaatctgtct tcctcgccaa tacttaaagg caaggagaaa cgatgagaag gagaagacaa 2280
taaagagtat ggagaaggag atggggaaaa tggttgagtt agcattgtcg gagagtgaca 2340
catttcgtga cgtcagcatc acgtttcttg atgtagcaaa agcattttac tactttgctt 2400
tatgtggcga tcatctccaa actcacatct ccaaagtctt gtttcaaaaa gtctagtaac 2460
ctcatcatca tcatcgatcc attaacaatc agtggatcga tgtatccata gatgcgtgaa 2520
taatatttca tgtagagaag gagaacaaat tagatcatgt agggttatca            2570

<210> 533
<211> 1670
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> myrcene/ocimene synthase

<400> 533
caccatgtaa taagtctccc acagttcagc gtcgttctgc gaactatcag ccttctcgtt 60
gggaccatca ccatctcctc tcggtcgaaa ataaatttgc gaaagataaa agggtacgag 120
agagagattt gttgaaggaa aaagtgagaa agatgctcaa tgatgagcaa aagacttatc 180
ttgaccaatt ggagttcatt gacgatctac aaaaactcgg ggtttcttat cattttgaag 240
cggaaatcga caacatttta acatcttctt ataaaaaaga tagaacaaac atccaggaga 300
gtgacctaca tgccaccgca ctcgagttcc gacttttcag gcaacatggt ttcaatgttt 360
cagaagatgt attcgatgtt ttcatggaaa attgtgggaa gtttgaccgt gatgatatat 420
atggtttaat atctctttac gaagcatcat atctttcgac aaaattggat aaaaacctgc 480
aaatattcat cagacctttt gctacacaac aactcagaga ctttgttgat actcatagta 540
atgaagattt tgggtcgtgt gacatggtgg aaattgtggt ccaagcgttg gatatgccct 600
actattggca aatgagaagg ctatccacca gatggtacat agatgtgtat ggaaaaagac 660
aaaattataa gaaccttgtc gtcgttgaat ttgccaagat tgatttcaac atcgtacaag 720
ctattcatca agaggaactc aaaaacgttt ccagctggtg gatggagaca ggtttaggta 780
agcaactcta ctttgcaaga gacagaatag tggagaatta tttctggacg attggacaaa 840
tccaagagcc tcaatacgga tacgttcgac aaacaatgac gaaaataaat gcactcctta 900
ctacaattga tgatatctac gatatctatg gcactcttga agaacttcag cttttcactg 960
tcgcgtttga aaactgggat ataaatcgtc ttgatgaact ccccgagtac atgaggttgt 1020
gttttcttgt tatatacaat gaagtcaata gcattgcatg tgagattctc agaactaaaa 1080
atatcaacgt gatcccattc ctcaaaaaat cttggacaga tgtatccaaa gcgtatttag 1140
tagaagcaaa gtggtacaaa agtggtcaca aaccaaattt ggaagagtac atgcaaaatg 1200
ctcggatttc aatctcgtcc ccaacgatat ttgttcactt ctactgcgta ttctccgacc 1260
agctctctat tcaggtcttg gagactttgt cccaacacca acaaaacgtc gtccgatgct 1320
cctcctcagt gttccgtcta gccaacgacc ttgtaacctc accggatgaa ttggcgagag 1380
gagacgtctg caaatccatc caatgttaca tgagtgaaac tggagcatca gaggataagg 1440
cgcgttcgca tgttcgacag atgatcaatg acttgtggga tgaaatgaat tatgagaaaa 1500
tggcacatag ctcttcgata ctccatcatg attttatgga aacagtgata aatttggcac 1560
gcatgtctca atgcatgtat caatatggcg atggccatgg ctctcccgaa aaagccaaaa 1620
tcgttgatcg tgtcatgtcc ttactcttca atccgattcc tttagattga            1670

<210> 534
<211> 114505
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> Similar to Nicotiana 5-epi-aristolochene synthase

<400> 534
gaattccaca tgatgtgttt aatatatatc atagtctatg atcgcaagtt cgcaacgatt 60
ctttcttgat tgcatgaaac taatttatgg gtttttatcg ggtaggaata tatataaata 120
tatcaaagtt cgttcatgtg atttgcataa atgtcaacat gattgcatat aaaatattgt 180
tgattaattc ttccctcaat atatttttgc cagcttcact tcccatttag tccatacgga 240
tttgctagct attagtatat ggatgaataa acgatactca tgtgcttgtt gcaagtgttt 300
gattggttgg ttacatcaac ctaattaact caatacatat acatatatgt atagtgcttg 360
caacccatgc tctcatgtgt tttaatttaa ccaactcagc gacatgattt tccaaagaat 420
gtcagttttt aattttttaa cttcaaatat atttttttga ttcgaggacg actttcttat 480
actcgtcgac caaaacgatg gacatctaaa ggctatctaa tattggcttc actagggata 540
catgagtcca aagatgcact ttctacattt ggcatgattg tcaaattaga tagccctaat 600
gaaactaaca ttagtgggct gttagtcgca cttaagaacc aaaacctact ggtaaaggag 660
acttggaggg tggaaaaggc gggagagagt attaaaatgt ttatgaagca ttatagaata 720
cctttgtgcc aaatatagta tgaggaatag caacaatctc tcctagtgtc aagtgtcaac 780
caatcaaatc ctctatttta gacatgagga attgaagagg ttatactatt ttagaaaaca 840
ttgggcctaa gtagacagcc caacaaagca agtagaaatt gtataaatcc acataaaaaa 900
ataagaaaga aaactaaaaa ctgttttttc attagtaatt ccgtatcaat actatttttt 960
gagcgagttg ttcatataaa tacatgttgt ttattgtact tgaagtataa ttcaaagttc 1020
aagcctaacc aagggaatgc tcataatttc gtcctaatac cacaatgaag agtcacattt 1080
atatttatac aaaaaacaga tttttcctta attgttgaac caaataatat atccaaatat 1140
ctaatacaat agccatgaca tgtttattct gttgatatat ttattgtttc gatggcgtgg 1200
ccgaacaaat tatacaattt taaatccaaa gaaaaagttt atataaattg ctttcatcat 1260
ttaagatgta tggtcactca atttgaccca atggtcagag tttggaaccc atttggagat 1320
caacttatgt ctaagattta cgtattaatt gggaatatta cagcatttac cgcaacattc 1380
gctaacattc ttaaatacta ttagcatcga tagctgtgta agtaatcaac tgtgtatgac 1440
tttttttgtc tacgaattgg tatgatttaa atcaataaaa tgttggtttt tcctaaagac 1500
tatagtctat gtaagcatca tcagaaactc accggcctag cgtcagacct aatattagga 1560
attagggaga caaatttaaa aaaaagccta gagacatcat aacctaacat ttttgttgga 1620
tgaatctgaa tccactaacc attacagtat caaatacttg gagtctaacg cagagttgac 1680
aagaaatgat acctttcttc aattcttttt tacaaaaata tcaagtcatc tattttatca 1740
ttattcaatt tagaccccat catctttata ttttcctaat gtgggtcctt aattaacctc 1800
agccaagagt agataaatca cctggcccac tgtataaaac tataaattaa tgtgctgatc 1860
gcaattatag gattttacgt agcatatgtc agcaaaatgc cttgtcgtat cttttttgtt 1920
tttattcgct ttaaatatta gttcacgttc aatggtcttt tgaacaaaaa aatctctgct 1980
tgcaattgta attttaaatt ggttagtgga agttaatgtg gtatctcacg atacgttcaa 2040
aattagggac ttcgtacaaa agaaaaatgt agatgttcag tgagatgtta ctagtccaat 2100
gtagatgttc agtgagatgt tactagtcca atgtgtaact actacgaata catattattg 2160
gtttaattta tggccttttg tttagtaata atccataacc tcaattagca aaatacatcg 2220
gagatgtttt tttagacgtt agttttgtaa aaaacaaatc tagttgattt tacaaaggaa 2280
attaggtgag agttctgttt tcgaatatat caatgaggaa gttaagagag actagaagta 2340
gttgagcaaa ctttaaaatg aagcttcatc aaaaataaaa acttaataat gacgtatata 2400
tccataaaac aagaaggcaa gtgtactgtt gagagaagtg aatctttcac tccaactttt 2460
ctaaattctt gagctgcttg agtcattgag ttttgtagct ggcaagggtt gtgctggaag 2520
tgtctaaacc aggtcgttag gagcatagag acttcaaatt tcaaagcaat taatcatcaa 2580
ataaggaatc aagtatcatc attttcgaat gactcgtccg tctaaagctt caaatttgct 2640
gtagaattgg tttcagaatg actccccatc atgacattgt cctcgtaaaa ctgttgtcgt 2700
aagaccaata aacaataaat ccgtttgtaa attctataga aaattgttaa aaaagtttac 2760
gataaaattt gaagtaaata acgtatggtc tacatttact ctcgctgatt tagttggcgt 2820
atgatcataa ttaagtctga ctatgtatta ggagaaccca cgtacgttct aaatcatgct 2880
ctctaactta taattatata cgttatctaa cttataagac gaaacgcgac gtaactacat 2940
aaataaaatg atctttaaac agcatcaaac tatttggatt ttttgtctga acacacacat 3000
tctgatatgt gaaacaaaaa acaaaaaaaa aatgacgtaa gcttctcacc cttagtgcaa 3060
tgggggagtc actcgtgtag ctacatcacg cttgtaaagt agcttcaccg cttcgtgaaa 3120
ggttatatct gaataataga taatgataaa taaaaaagta atgtatgata attcctccct 3180
ccctatatat gattagagaa attaaaccaa taatatcata tctttctcca atagcattga 3240
agatctcctt acctctctct ttctctcgct acttatattt atttccctaa atccttggag 3300
ctaggagaca tcgtgccgtt ttcttatttg aaagacaaga gggagataga tggaggtgaa 3360
ggttagaaga gatgagttgg taccctttgt agcaatggct ataatggaag catgcacgat 3420
tgctcttacg ataatggcga aaacggcgtt gacgggaggg atgagtcctt ttgtgttcgt 3480
tgtttacaca aacgcttttg gatctattct tcttcttcca ttttctttct tatttcacag 3540
gaatgagagg tcggtccacg ttcagtattt tatatcatag tatatatgtt agtactaatc 3600
aatcttggtt cttttctgat ctttggtttg tatgatgata ttttatactt gcagaacaga 3660
acaatctatc ttctcttggc cactcctcgt tcgcgttttc tttctaggtt tcaccgggtg 3720
ggtacataat ctatctttat taaataatgt tttcttagga agttatcata ttgattatat 3780
gagtcgcaga ccagattctt acgtactaat attattttgc aataacagta acttcgtggt 3840
cctaaaacca aatcaaaaga tgaggtccat gtttcgaaaa tctatacgta catgtatcaa 3900
ccactaattg gttggatgaa tattctatgg catggatttg cgacgtcatg catattcaaa 3960
aagatacaaa accgcgtgcc gtttactcgg ttataaaata aacaactagg cctaatatgt 4020
tctattattt tccacatcct gacgtttcta tgtgagcggc gtataccaca caccatgttt 4080
tatttgtgtt aaaatagaaa taaaaacttg tgtgacgtat atgttggttc atataatagt 4140
ttactcactt gtgagaacac acgcatttgc atgcattgaa cgtacataaa atgttattca 4200
tgcatatgca catgcactga ttatattgta acattttaaa tatgtgaagg atatttatgt 4260
tccaaaactt ggcatttgtg ggactacgct tcagctcacc aatagtagta tgtgcaatgg 4320
gattgcaaat cccgtccttc tccttcctgc tctctattat tctcgggtaa gacatctctc 4380
atcaccatgt caaactctcc acataaatta tatgaatgtt ttcaaatata tatataataa 4440
atatacatgc atgtgtagaa ggagcaaatt ggattggaga aacacgagta cgagggctaa 4500
actgatggga acaatagtct cgttaagcgg agcttttgtt gaagagttgt acaaaggtcc 4560
attcataaga ccagcttcgt ctgcttcccc aaatcgtttt cttaaatcag tccctaaact 4620
tttggtctac tacaacctcc ccgacaattg gtttctcggc tgtatctttt tggccgtcgc 4680
tgttttttct gtctccctgt tcaatgttgt tcaggtactc aatcttccat tacggaaacc 4740
atcgttatcc ttatgcatgt tagttacctt tgaggttaat atatatttct tgtttttgca 4800
tgtctttggc agacagggac ggtaaaaaag tatccacatg tgatgaaagt ggcttcgttt 4860
tacagcatag tcgggacgat ccaatgtcta ctattctcgt tatttatgga aagagacctt 4920
agtgcatgga agatccaacc taacttcgat ctttatctca ttatcgccac ggtaattaaa 4980
tctacttttt ttttttgtta ataacatgca tttcactaga tttgatcatt tgaatccaag 5040
tagtgatata acgattacgc tagatcaaga ctcaagacta catgttcagt ttacttataa 5100
ttgattgagt tttaaaagat caaatacata aagccatcga ttgtaattaa cgtttctaat 5160
attggtgact ataatgatgt gtaaaaaaca gggaacattc ggaagtgtaa tacgaacaag 5220
tgtacacgta aagtgcaccc aaatgaaagg accttattac gtgccattgt tcaaaccctt 5280
tggtatcttt tgggcaacac tctttggtac cagcttcttc gtcaacagtc ttcactacgg 5340
caggtccgtg aacaaattca ttaatcaata ttctaaatac taattagcat attatcacgc 5400
atgagtatta agctatatat gttggtgcat atgggtgcag tgtgttagga gcagccatag 5460
ctggtgtggg atatttcaca gtgtcttggg gacaattgaa ggaaagcgaa gaaaaacaaa 5520
gttcaaatga agaaagaaaa tccatcaaaa ctattcatca tcgcgatgaa gatgaataca 5580
aagttccatt acttattaac caggaagaaa gtcctgtatg aattttgtat tatatataga 5640
atatgagggt cgcttaaata tatttttggc ccctttcttc gttttttatg gcgtgaataa 5700
ggagaaatgc gagtgagagt gttaagtggt cagtgtcgta tgggagattg ctgaagtagg 5760
ctttttggtc cgaaaagcaa aacctgccca atgtatatac atgtctttga atatctacag 5820
ctcgcttctt atgtttctat gtaatgaata atctccaatt catggatcaa ctattgtatt 5880
cctgccatta aaactaatgt aaatatcttt catattttgt tgttcaacat ctagtgtaaa 5940
tagctacatt gttgaagtta ttcaatgcga gaaaagtcgc atataattaa agtcgcgtat 6000
gttaaatttt ataggtttct aacacaaaat gaaatgatac taaaatttga ttagtcattt 6060
tatttatatt atttataatt ctacctaaat ttagatgttg aacacacttc ttcatgtgca 6120
aaaaaaaaaa aacacttctt caacggctct tacataatgc cacagccgta gtgactaaaa 6180
gagcattatt tgaaatattt tttacgtagt aaatgtaaat ctcaaagaga aaagtcaatg 6240
tatattcgcc tcaatatata acgtctatac gctttaaagg tgcaccggca ccgtcatgta 6300
ggccaagttt aataacttaa acagattgag actggtctaa aggattaaat acaacaagtc 6360
acggggtgga atttgaacac ctgagaaaac aaactgaccc atttcagtga atgtcggatg 6420
tctcatgtct acatttatct tctattataa gcatctaata ttttgggttt tcatttacac 6480
aagaatggtc aatggtgaat gctcgcaaaa tctaatttgg atattaacaa caaaccggta 6540
agagatccca aaatctaaac agcttgtaag aataacactc gtctctggct agccttggtt 6600
taggaagatc ttgagctatc ttgattctct tctacaatat cttgaactat ttgttcggaa 6660
taatatgaag tatcttgact tggtttcaag aagcttgaag tctcttgaat gtcttcatca 6720
actgttattg gagctgttat tgcgggtaaa cataaaagag gcttaggtgg aatctggaga 6780
gcctctagac ttccctctaa catttcaaca actttgctca ttggtggacg atcatatgga 6840
ttggtctgaa tacaccacag acccaccaat accattttct ttactatctt ctcatcttct 6900
tcttcggtta tttgatctgc caaaaaactc atgatttctc ctttctcaag atctttataa 6960
atccaatctg gaaagtacat tgaagtatta ctggatccag cattttgagc tcttcctatg 7020
ttccttgctc caatcatctc aagaaccacc attccataac tatacacatc agacttatga 7080
gaaactcctc caaaattctg ggagaacact tctggagcaa tgtaccctat ggtgcctctt 7140
gcatgtagca ttgaaatgat gctttcatta tttttgcaaa gcttagcaag accgaaatcc 7200
gaaatcttag ggcataagtc tccatctatg agtatgttct gtggctttat atcgaaatgt 7260
acaatccttg atacacaatg gctatgcaag tattctaggc catgagacac acctaccgca 7320
atgttgtata acgttttcca ttccatcttc gccgacatat tcttggagat gaacttgtcg 7380
agggatccat tcggcatcaa ctcgtaaatt atagctttct tcctcccttc ataacagaat 7440
ccaagtagag aaacgatatt agcatgagat gtcctactca tgctagctat ttcattgatg 7500
aagtcttctc catcctcgtt tgactccttc aagatcttca ctgcaacatc tcggctgcca 7560
tcaggtaact tccctttata gacagttcca aatccccctt tcccaagaac attctcaaat 7620
gattttgtca tcttcttgac ttgtacataa ctaaatcgtt tcaacattac cactgcttcc 7680
atgttcttct cattcaaatc actctttctc atattatttg ctctaacctt tcccacaatc 7740
acaataatga tcattgtagc caatactgat gaaactccta caagagaata agccttaaaa 7800
cttaggtgtt atatacatca aaaatgagta agatagttga gagtaatttc accaggtttc 7860
ttctaaagtg taccaagtat gagttttaac ctcaatggaa tatttcctgc aaatgtatta 7920
cagaaattat ttcgattaac aaaaaataaa atgatacatt ctcccgtagg tcaaagaaaa 7980
gaaaaactta ccttttgctt ctgttccagt tttgatgttt cctgcctctg ggaccgttga 8040
gctattgatg tttcctgcct ctgggaccgt tgagctagac ggacaaaacg tgatgacaaa 8100
gttggagaag tttggacaag tgaaactgct gttatcaacg tcgtaggcgt aactataagc 8160
gcttgggcac acgttattga atgtccgcga gtagatcgtc cgcttgcata ttcccggtgg 8220
tacgaccacc ccagaagaga gtccgataca gcaaagctct ggcaactggt atctctgaca 8280
agtggtcatg caggctattg gatggtgcga tccaaggcca ctactgttca ccattagctc 8340
cgagggacat gtctcgttca tgtcaataac gcattcaatg cttctgcagt ttttgttctc 8400
gggggtcaca agcaaaggga ggttgtaacc attgaagacg ttgacgacat aatagtcgac 8460
accgtaagaa gcgaggttaa actcgaccac tgttgttgga tctatgggga taccgaggca 8520
cttgattttt ccggaggtgc agtctcccgt ggcacatgag aaaccccctg ttgagttggt 8580
ggagcagagt gtcctacccc agaaacgacc tatccatgat gacggcgctt tgatggtacg 8640
cgtctctcct ttctcaagaa caaaaccggt tgtttctagt gatctcctat agccgtaggt 8700
tgcaggccat atggtgtatt ggcatttgtt ttctatcgta aagctccttg acattgctac 8760
atataacaaa aaaaaattca agatatattg cagagatttt aaacgtataa tataaagagt 8820
aggtgaagag tttggtttat acatggacgt ggcaatggac gtggtcggga tgaagaaggt 8880
ggcgatggag gtgcaggtga cgaagctgat aattaaacaa aacattacta ataatgaata 8940
tatatatata tcagagcttt attgattcta gggcctagtg ggaagcacaa agagaagcct 9000
ataacaaaac aaagtaaacg aaagaactct ttattgaatc tgaaacttgt tgttttatta 9060
agacaagaca cacacactta catactgatc ttaagtacat atctgaccaa actaaatgtt 9120
gtgactgttg aaaactgccc aaactaaagt tacgactctt acaagcacct tttgctataa 9180
cacagaaact taataattaa ataacatatt accaaactca attataaact agcaaggagt 9240
acgtaggtga agagtttggt ttatatacct ggaggtggag ggagcatttg agctgaaggt 9300
ggaggaaata gatcaggtgg tggtggtgga gcaccagaac ctgtaaatta aacaaaacac 9360
ctatcatatt gcaaatctca gattcataat tgcaacggtc gaagatcttg gagaattaaa 9420
gtaccggaac aagcggatag atcagtgttg actccacatc gaaggttgag accgagagct 9480
tgatctgtag tgatgttgaa ctgagcgagt aaaccaggag tgttgtagat ggtgcagaga 9540
cagctaaaat ctttctccat cgcttccttg atcgagttgc aacaatccgt cgacggcttt 9600
gttgtcgtgt tcaagaacct gaagcaggga actatcttgc tcacgcactc agtctgtgct 9660
tccacctcca ccactgtaac caaaaccgcg aatatcatca tcgccgttgt catttttctt 9720
tcttggtaaa tggtaatgga aggtcgagct ttttttcttt gaattacttt taattttgct 9780
ttagaggttt tgtaatatta tataattcag tggctcaaaa ccaaaacata tgaagtcaaa 9840
gagataaagc caaaacaaga atataccgaa acttatcgtc gtcttgactt ttgataatcg 9900
ttgaatccaa agaattgtta accgatcatt caaggaaaaa gagaaaaagt ctttctctct 9960
gttttcattc aataatcaaa agctatcgta ccttacaagt tacaaccata aggaagccca 10020
atcactaaaa agtactcccc cataatctca aagcccaatc actaaaagcc catttttatt 10080
aatctcatcg tttttttttg tttttttttt gtgacattga gtaaacaaaa tctgggggaa 10140
gaaaactaga aaagggcaaa taaaatgaag attctcttct gaacagaaaa aagagacaaa 10200
atatcgtttg tctcttgaaa gacaaaaaaa aaagtttggg aaatagaaga caaaaaacat 10260
atctctaggt cttactattt atgctctgca caaatacaaa ccccaaaaaa tacctgcaaa 10320
attgcataga acatctcaaa tatcctctta ttcacggtgc ccatcccttt cttgccagtt 10380
gccacttgct tccacaaaac tctcttataa tttactcaaa tctaatacac cagttaatag 10440
gtcaaatgct attcaaattg ttataacaat gttctttgcg atgacataat tattacaagt 10500
tacaacaact ccattaatta cttttactat tttttgtctt gacgcagtcc gttatacaac 10560
tggaattcta atcattatca cagctatcta cgccctaata taatagaacg ggcatgctag 10620
tggctactgt agtacatgga cagtttaatg ccaataattg aaagattatt ccaaatcaag 10680
aaaaagctac gtatacatga catgtaatta cttaatttga atatattgca aaaaataaat 10740
aaatgttcaa ctattttttg tactcctcca tggtttgaag aacggaagaa ataaccaaca 10800
aaaaagagta tcatccatgt ctgttttttt cgtatctaat ccaagaaaat aaactaccta 10860
gctacttttt gaaatcccaa aaaattatta cacattttgt tcttttgtca tatgcgtgta 10920
aatgaatgat atcataggat cttcaacaat caatgttcat catttaaacc ttccatcgcc 10980
gcaacatctc gatcatgatc tcgttccacg tgtcgacagg accaggtaga caccaatgca 11040
aacaatcatt aggaattctc tccggtacac cgttcttgaa cgggtccgcg tacatgtacg 11100
gaccaggatg tccgtctggt ctcagtaccg acatagccgt cacgtccaac acctctaacc 11160
tcacctcagc cgcagccgcc gtatattcct caatttctat tttgcgcatg tccaagtcca 11220
gaccttctaa aaccttccct tcgtacggct tggtcatgtt acatgcgccg agactgtccc 11280
aaggccgtcc ttcaaaatgt gatggcgaaa atgtcgtcaa gatcacctca cgaccacttc 11340
cagcaaccgc tctcaacgtt gttcttatcg cttttctaaa tacatcataa aaccctacct 11400
cggtacagtt acttgtttca caagaatgac atcccaaaac cgaaccagac tcgtagtaaa 11460
ccgctggatg cagaaaccaa tgtcccacag agactacgac cgtatcaaaa cgttctaaat 11520
cattgcccca tctctcatcc acgcggtcta tgtgcaatac attgtggtcc aagtttcccg 11580
atttctctaa accggccacc aaaaacgggg accagtaaac cgagacagtg acgttgtgtg 11640
actcgaaacg ccatcttctg aatttattgt cttctccgtt tctatagacg agatcagggc 11700
tagagacggt agagagcaag cataaaagag actcaagctg atttctagcc atggaatcac 11760
cgataaaagc tagatgctta tctctcataa gatcaagaaa ccggttcgag tcgaatctcg 11820
gtatatcgca ttcgtttggt ttccatttcc agtaaagata accggaatca ggtctaccat 11880
ggcggaaaca attctgacca tccttgattg ttccacatgt tgaaccattg tagagtggac 11940
caatctcgtc tctgacccag ttcccttgcg tataatcgca taaaggttca tcttgtatat 12000
gatcaaaact ctcttggctt tcttcttctg cagatttaga aaacaaccct aaagttaaaa 12060
aaatccattc agtttttgga tatacacaat attgaagaag ttgaataatt accttgagaa 12120
gatgaagaga agctagtgat cacaacgtta gctgcagagt cttgaagaga ggtgtcttta 12180
atggaggaga atggattatt aaaacagagt cgaaacagag ctattggtat aaaagctaag 12240
actataaaaa ctatgatctt cctctgactt ggaacatttt gttgctcgtt taatcccatt 12300
tcaggaacat agaacaactt atcttctttt tctctctttt attttggctt tcgtgttttt 12360
gattattgat atggagcttg tttctaagta tatgtcacat cgttttttgg ttgttgttct 12420
tgttttatgt ggaagagacg agacgagtgg ttcaatggtt ttggtccttt ttggaccatg 12480
gaggtatatt ttactcaaaa tctttattat ttgtctatgt caatgctatt atttgtgctt 12540
aatttacaat attttccaca tgaaaaatat ataaataatt ttccggagtt gtaagtaggt 12600
tttctttact ttttttttgt tgcgtagaga aattctaaat aattgtccac cgcatatgaa 12660
tatatgcacg attttttttt tatttttttt tactcaagat tctgttcact tttcgttaat 12720
gaggttttaa aagtttgtta aggagattta ttaatatgtt tggactatca tagtatcatc 12780
atttggttgc taaaatatat taagattata tcaaattatc aatacaaatt tattagtttg 12840
tggtggagaa ggaagttgtc tttgttcagt gagtggccgc cagtctgaaa ttgtacagac 12900
gctgatggct ttagtctgaa tatggtaaat gacgaaatta gccttggata atgtgcgtcg 12960
atgacattct ttctggcttt gctcgtgtca gggtataatt gtcagtgtac acagatgccg 13020
cgatgtggtt tgattaagtt aattaatcct aatatcctat aattagatgg tgacacgtaa 13080
gcaacgtagt tcaaaagact tttcttaagc gttatctgaa gtgaagtctt aatcattcga 13140
atatttattt atgtctcatg aggaataatt aaatcactgt taaatgaagt tagtaaagtt 13200
ttagacactt cacacatctt tttttaactg ttagatgagt gacgttagta aagtttgaca 13260
cttttacaca atttttatga tagaaacagt gatgcctgtt gtacggcatc aatgatttca 13320
tggcatagtc aacgcagaga tgattcattt tacccaccaa catgtaatca ttttactaga 13380
cggtaaaaac ttttagagca ataaaagata catttgtatt tgtagttcaa aataagattt 13440
cacagattca cgacgcatgc agtttgtact gaatagtaca cttgacctaa ttatgatcaa 13500
gtatgggtaa atataacagt gaaatgctag tctacacata tatatcaatt tcaatactga 13560
aaaaaaaatg tggatcaaaa acttacatat aaatcactaa ttttaataat ctagctgcta 13620
gtaaaacaag aattttgaga tagtaattgt ccactacatc ataattaata gctgttaaat 13680
gtcaataata taaagtggac acaaacatta tgtgtagaac gcatgtggaa gatagactca 13740
aacaacatgt gatgaaagat gtgttatata gttttgtttt gcgatgagtg tttcgacttg 13800
ttgtcttcat ctccgttaac ttcggtccat tccattcttc catgtgccct cctctttctg 13860
atcattcaaa ttgttaccca aaccaatcat ctttgcctaa taaaatcatc aataaaatta 13920
atggtcaaaa cattaaactt aatttttcca aattcgtggt aaaaaaacaa attgtcagat 13980
gaccaagatt caaatcatcc cactgcgatt tcagttaatt gttatttaaa tttaaatatt 14040
attatgaaaa gaaaaaacaa atctagtaaa gatttagaac caacattcaa agactgacac 14100
tcaggatttg aaaattaaaa gtagtgacag gagataatgg tgatgtagta gctcaccagc 14160
ttccaataat ttctcttttg acaaaatata aaatgattag tttaatttat gccagctgga 14220
tcacttcatt ttcctcttaa tatctagcat cataagcagt taacaaaaag acataaaaat 14280
aaaataaaat aaaataaaag taaaataaaa ataaatctag cataaacatc ttattaagta 14340
acaaaaggtc taccagtgga taagaatagt attgtatata ctttgtgaaa ataattgaaa 14400
tttctgtaaa aaaaaaaaaa acttatatgc aaagctcaag agtcaagagt aagctggtct 14460
aaactctaat tgggctatat taataaatta cgcctggtaa tagcttaaat agtgacgacc 14520
caggataggt ttatatgggc ctatatagct ctgaacagaa gcccatttac ggttacagtt 14580
tgttattaat tgtccacgcg ccataaacca agatattttg caaccgtcac tttttcaaaa 14640
ccgcgattta gaaaccgccg gagagttcgt tcgccgccat gaaaccagca agtgctacgg 14700
tggctaaagt agacagcgga ggagaggacg agaaattcga ggtggggaag gtatacgctg 14760
tcaagctgac caccggagat cagttcaatg gcatcgtctt ggcttatgat tctgaaccca 14820
acttcgccgt tttcgatatc ctttttcgaa atcgctactc gcagctcgta gattcttatc 14880
tctgctactt cgccttcttg atttcatctt cttgtgtttg ttttcgcgta ttccttgacg 14940
gattagtgat tttacaagaa ggcacgaagc ctaaacctct ggattcgaaa tccttacgga 15000
tggtgaatgt gaattacata acggagatga agaatctggg gagggttaag gaacgtctcg 15060
ctaaaaatac tttggttaat cttgatggac tcatagagaa agagaatcat gctattaggt 15120
gatagttttt gcaatttgtt gtgaaaatct ctatgattgt ttcgatttta tcactgattt 15180
tgattaatgt attatgcagt aacgtcgaga agattggttt tggtgttacc gcagaagggc 15240
agatgatctt tgacgcgatt tctaagacgt aaggatctct ttggttcttt atattgaatg 15300
gatgatgatg atgattttaa tacaatccag tagtgtttga aatcttgtta atggtttttg 15360
ttagttcttt gtgtgaagaa gataacaata gcttacattg ttactgcttt tgctactttt 15420
tgtgaacaga tttgtgcttt gtttctgtta gcaacgaggg ttggatcaga tgcttgctta 15480
tataagtaac tgtgaatcgt ttagtttttg aatctggatt caatttagtg tttgtattgt 15540
tcttggtttc cagaagatgt aagttatttg gaactaatat ttgcgctatg gttgattgtg 15600
tcttttgctt tgcttcattt gttgctactg tgaaaatgcc tgtaaattag catcatatct 15660
cacatcttta ctagagtttt catacttgtc atggcatagc gtttttattg cttgtggttt 15720
ttagaagatg caagcttttt gggactatat atttgacgaa ttgtgtcttt agctatgctt 15780
cagttgttgc tgctatcaag tcacaaatct ttactagagt ttatttatgt tggacacttg 15840
gactacttgt catggcattg ctgaaagtat aagctacaat ggagtaaaat tgtcaaagaa 15900
agtaattatg tagtttttgc taccttgggg tgagttacat tatataaaac tcgacatggt 15960
cagaggctac ttatgttgtg gaccttgagt tttccctgtt ttgcatctaa gaaccgtggt 16020
gacaaatggt tttatgctta tgatgataat cattctattg acttttagca tatactcttt 16080
ttttattcat tgttatgtga tgctgcattc tccaggcttc ctatacgctg ggtgaacaaa 16140
gaaatgctgg taatgggaga tgtgtttatt cgtagccctt atcattctga ttgtgtctat 16200
ggaggacccc gtatggtcaa tgaacgagta aagcatgtgg taagtgtcaa taccaagtaa 16260
taaatgtaat atttgcgttt catgtcatat ttatacagtt ctttgttgtg tcacagctgg 16320
ggcaggagag aaagaagttg caactcagtg acacctgagg atattgaagg agttgttcaa 16380
tgaacataga gcaatagcgt aagtctctta tccctagaag taccctagat gtgataccat 16440
gtgtaaattc gattcacgag aagaagattt agagattttt gagttgcaga gatttaattt 16500
tggtgttgac attgacaaga acacagagaa tgttgttgtt acactgattt gagacttgaa 16560
gctttagtga atggatggct tggactagtt aagacttagg atagtgaaat tctaagacct 16620
tgatctacaa attgtgaagt caccgacttt ttacaaatgg gtctttagcc ttttcccaag 16680
tcatagccca aatcacaaca atgcccatat tgaaaatctt attaagcatg gtgattagag 16740
aaatgactaa tttatagcta tgatgtggat tcaatgtatt attgatatat ggctcctaca 16800
aagtcacatt cgcaagcttc tttaatgtca aatctaaaag agtgttacat tcctttttgt 16860
ctttctttaa ctaaaacaaa gctttctcct ctctaatccg cttttgcttt cgcccccata 16920
aaaaaaaaat gcctttcgct ttctactttc tactttttca tccctttgct gaagtctctg 16980
taaaaaaaat tcaatctgaa aaaaaactta caatcttact ttattgcttt cagtcactgt 17040
gctcaatgct cattggtttt cttttatgct catttccttt ctctcacgtt catcctcttt 17100
tttccttaca ctctttttac attaatcaaa aagaatcgaa actatattct aactgtgcct 17160
ggttatatgg ttcgaacttc ggtcacacgt gtgtgcgagt gtccttgtaa acaacatgaa 17220
taggttgggt taggtaaaga gtgattgatg atgaaacaaa ggactttggg aaggaggaaa 17280
cgtcgttgtc cactagagat atgaaagtgc aatagtgact aaatcttggt ttgtgaccat 17340
aaacaacaaa aagcaaaccc acgatttttt ttctaaagta aaatacaaat gagagacgct 17400
ccctcgagaa actaagttca ctcactctct cacgccctac gagtcgggcc atgccaccat 17460
tgattcttct ctgttctctc ttttctttta ttttttattt taatgattcc ttcactaaat 17520
atcatctcat atatcacttt ataattcttt ctacttttca agcatccaaa gtttgattat 17580
tttaatgaat atatagtgta tcttcttctc taaagattaa aggcaaataa agaatccatg 17640
tgcaaacttt gtttctacat gttctagcat atattccctc gcatttcttt tttcttctgt 17700
ttcgctttaa gaacaaatgt taaaatatgc ttttgtatgt gcttataatt aaatcccatt 17760
acgtacttga ttagtagtcg gagaggtgag taacgtgagt ttgatataga ttgcatgtaa 17820
tggtaacatg tacgtagtgt ataattatga agaaatgatc aaaatagcta tgaaatacga 17880
atgtataaat aggcgatttg gttaaaaata tgcgtattat atattctgtt tttattccta 17940
ctaatatcca catgatctac atgcgcttat atacacgata caaactcata tacatctaca 18000
tgactacatg tgtatgtaaa gtaatactaa taaatctgcc cattttctat aaattaaaat 18060
gaatgcaact cctgtcatat aatttcattg ttttgtctct accccattcc cattagttgt 18120
cattatccat tattctataa gaaaattaat gtatattctg tttgagaaac caagtgctcg 18180
tgaagtgtat gatacaaaaa ggtatgcaac taatggcaaa cgcgtgtacc aaataacagg 18240
acaaggatca attaagatag taattaaaag atgattgtct ttatacgctg atatataagc 18300
ttaggtccct ttgtgtcccc gtgtgtccta atcaaaaccc gcaagagaat taaaataaat 18360
aaaaagttaa taaacaatga taaaggtaat cccccgatga ttaatatgtc caaatgtgtg 18420
ggctggtcat tatttattta taattagcat ttagcagttg ctaatcacct aaccatactc 18480
tctctttact tttgcatcat tttagattaa atagtagtgg gtgaagcttc tattctttct 18540
cttataaaga tattttgtat ttatattcct gtaatagtta tcttgtacgt atttatttat 18600
aactccatct ggttcacgtt caggttgtca tgtcatattg atgctctgct cttacaacat 18660
accatttata ttcataattc atgtcatgaa ttttacaaaa ccatgccaac cttttgtaaa 18720
aggaaagaaa aagttaataa atagtgacta gtacgagagt aaaagcagta acacatttcc 18780
ttacgtacat ttgagtggaa tcaaaatggt aacagtgcat gtttgatatt tggatttaaa 18840
atttgtttat gtcaatatta tcagtgtatg gttgaaaaat gggaaaagtg aggtaaacca 18900
aaataataaa taaacagaag aggagcgtca tgaggattta tagaaagtag ataacgttgt 18960
aatccgatag ataagtaaat gattagtata aagcatatga ctatgagacg agtgattagt 19020
tcattggagg gtgaacaaat aatgtcgtcg atggaaaata aataaatcac attactaaac 19080
taatcaacta gaattatgag gatggagaca ttttctcgac gtggggtgca cttctgtcgg 19140
cacaaaccaa cttagttata agattaaaac acacttttgt aaaatgtttt gttttgcagt 19200
aagttttttt ctttttcttt cacttcttat ttcctttttt acttgtaaaa tcgtgtgcat 19260
acatatataa atggatagtc aaagatggta tttttgtgtg gctaatgttt gaggggttcg 19320
agagagatag aacggtgtag ctacgttatg gtttcgtggt gagaccactt tctctgacat 19380
ggagacagat caacatcaca tgtatgctac tgctcctatt aattgttcct ctttactaaa 19440
atcaagagag aaattaacca ctatttttta cttcttttgt aatttgtttt tttcataatt 19500
tgattttctt ttgtatattt actgttgtta aaataggtat ataaaaccct taatcttttg 19560
cccaaaaaaa caaaaacaaa gaaatgtgtt taattatggc aaaaatgagg aaggttatta 19620
cattttgaac attaaatact tttttttttc ttttggtctt aaacaaatac aattttcttt 19680
tgtcttttta cgttcgtcgt tcaataaaac atacactcga tccacaacac acatgttcac 19740
atgcttcgtg ctcccacagg ccacaccaaa atcaaatctc accactactc atattatcct 19800
ctcacgtagc tattaacctt ctccacgacc attattgagt tcaatgtact ttttccttca 19860
tataatagaa acgttttatt tataaaattc aacctttcaa gaaaccaaaa aaaaatcata 19920
tatatacaca tacgtgacac cttacacgca tgcaaacgct actaaaacgc accgtgacaa 19980
aactcatttg gagtccacga atacgtagaa atcaaaaaca caaaatttcc cgccaaaata 20040
aaagatttga agagaaaaca aacacgtgag acacacgcct ccgtcacgtg aagtcacaca 20100
caaggaatca aaaatcttaa aaatccaaac aaaaaaacaa attatatata cttcgcaact 20160
tgattttttt tttgtttgat gatgaagctg aggaagggtc ccatgaactg ctgcgatcca 20220
ttaagacaaa gagctcagaa aaatctccac tcacaaatct tttgcaaacg ctcccctgtc 20280
ttatccatca gtacctgtgt gatgaggact ctaatgcaaa tactcttctc tctctctctc 20340
acacacacac actcacatga tcatatcttt tctctaacac gtgtgtgtta cactcactta 20400
ctcattttgc tttcttggga atctgcaaag ccattaatga tgagcttcgt ctctcccaac 20460
caaccaacca accccaaaac ccaattttta ccctttccat aaaagaaatt gtaaccaaaa 20520
ctcttattcc ttccccttgg ttggaaaact cttaattact ttaactcagc caataaacac 20580
ttttactttt cttcatcact cccttattac tatgtacttg ttaaaaaata tactctactt 20640
aaacagaaga gggttttttt tcttctaggt tttgtttcct tggtcctcta ctttcactcc 20700
ccaaatttta attagaggta gatgtttcat cacctaccca tgaatagcca cttaattttc 20760
tccttttaca aggagaagag gatgagaaag aggattcatc acttggcctt gttaacgtcg 20820
atgatgccct tacactcact cgaagctttg ctatcacttt tggtgtattt aaccggttat 20880
tctcgatggc catcgctttc atcagtctat agcatctcac tatcttctcc tgaaagtcaa 20940
atataaccaa aagacattaa ttagcaatct gttactccct tgttccatct aaacgtgata 21000
taacaaatcc tactttgctc aatccgtcac accaagtctc agggctctcg tggggattga 21060
caacagagga tagagaaggt aactcgttcg ctacacagag aatcgcggct gcagctatac 21120
tcgatggcca gtactcaaga aagctcgctt ctgtactaat tggtcatgtg ttagaaccaa 21180
cccaaaaatg tgctacctaa atgacattat ggatcatata tcatacaaat attacgtacc 21240
ttttatgttg gagagtataa tctctgtagc atgggagata aagaacccga gaaaggtacc 21300
cgaaggatcg atcttgtaag caaagaagct aatgaaatca aacggtgtaa ccgatcttag 21360
tctccaatct aacacactta gaacaagaag ttccattctt tttatagttt ttgcttcaaa 21420
taaatacttc actcctgcaa cctacattac attatacaga gatacataaa ttaaagtttc 21480
ttaaaaaaac agagtaaatt cagaatgtta aagaaagaat gataatatat gtttacctga 21540
aaatcaaaaa gagaaggaac gagaatttcc tccatctttg cagctaaaga caagcatgcc 21600
actgctaaaa gttgcattgg ccaaccactc gtttcctatt ttacagaaat taaagctgat 21660
taatataatc attgattact atatactcta ttaagtttaa ttacaaaatt aatttaaaat 21720
attatatagt agtaggagcg ttttaacact atgattacaa agttttcaat aaagccgata 21780
tatgaagtgg aaagtttact gcaaaagtat actattatta tgtaaacgtc aatgtaattt 21840
tttatcgaaa atataaattt caataaaata attaaaaaac gaaaaaaagt tccccagccc 21900
gctcctgttc tatcgtttac gtacattcca atataagatt aatttctact aaattattct 21960
ataccgatta taattttttg ctctaataaa tttttagtcg ttttcatttt tttctgaaga 22020
aaagtcaata aacaaatcga tccattgaaa aaaaaaaagg gaaataaaac tgactttttg 22080
gggttgttat ttgtcatatc aatataataa aaaaacagag acaatagaat taactaacgt 22140
tgacgttttt aaaacattta ccggtaatcg acgagcgtaa agaaaccgat ccatatagtt 22200
aacggcgagg tacgccgtta aaggctgaaa gttataatac gcttgtacct gtaaaccaaa 22260
caataccaca ctactgtaaa aaaaaagatt ctctgcatgt aacgattcga tcagcgtatt 22320
ttagcgtcta cacactctcc ggcggcgtat tttagcattg aaaaaaatga gaggtagaga 22380
aaaaaagtga ataggctcgc cttgagaatc catgcgacgg aatcttctct agcggaagca 22440
tcgagagatc gagtttgaaa tctagagaga taatcatgtc caggaacgaa gtgacgctcg 22500
tcttcgataa aacaagcgat agaatcacca ggccatgaat caacctcgga agacgagaaa 22560
tcaaccgttg actcaccgga aaacacaccg gagtcttctc cacaaaacaa atccatatcg 22620
ttagagaatg aaacagacat gtgtagataa tcactaaaac ggtaactcct cattctctcc 22680
ccataaccgg agatgaatca aaccggagct agataaaccg gtgagatcta gaagaagcga 22740
gaagagagaa gtgaaatgtg aggtttttga attttgtgtg gagagaagag tgaaggttta 22800
acacattcat ttgtttggat atataaacaa gaaacagaga ttttttgagg ttttaataat 22860
tttttattta aatgtgtttt tatttataaa aatggtgttg ttgcaaatga aacagagaga 22920
cggttaccgt ttccgttatg cccgagaaaa cgggactgtt gtcactgttc catcaatcga 22980
gacggggctg gtccgttcgt tcattgggtt ttgttttgag tttttttatt tgtagtttat 23040
gtttgtgttt tttgactaac atgcgctaaa gtgaaatgcg taggttagga acaaggagtg 23100
gtgtaattac gtaatacgtg gcaggttaag acgttgcatg agtgagtaca ttacagctaa 23160
tgtacgtttg tttgcatatt actcgtgaag agagaaggcc gtacgtgtaa tgtattaatt 23220
ggtgacgtgt aatgtattac ttggtgatta gcttaatggg cctggattat ggaacatttt 23280
ctgtgatttg gaccattttg ttggtcgctt agaaagaaac attttttcgt atttaagatt 23340
tggactttat tactattggt taaaaaataa aagcatcgaa aaataaatca aaattttaca 23400
gaggttttaa agtcatgacg cttaatcata cgtatatata taagtatttg atttgctaaa 23460
atgcaatttt tttggttatt gtttgctttt tatgtgatta gatgtaaaac tcctgaacca 23520
ttttaggcac atgacaaatg ctcaatagat ttgaggccat tttagattca atgatgattt 23580
tttaatcgaa tgtaattaat tgatgttttg cattatagtg caattttttt gctgttttct 23640
tgaattaacc gtatgataaa tcagtttttt ttttgtaata tcaagtgagg gaagaagatt 23700
ccaaatttta agattggtta tctaattatc ttgaattata aattagtagt ttaattgaga 23760
ttggttaatc agaggaaagc aaacagtggt ctggagcgtg tgggaaagag tagtggaagt 23820
ccttttcgta gaaccggaga ttttcttcac attccttttt gtatcaatat gtcatattta 23880
tttggtccct tcttggttta attatgccat aaaagtgtta aatcattggc ccgtttttat 23940
taatcactcc cgtagttact ttctttcacg tgtgccttac aaaatacttt gctccttcga 24000
tttagatttt agactttaat tataccattg ggatgatctc ggtttagatt gtagtagatt 24060
tttcgcttac ctctaatata tttacccctt attttagttt tcaggtgtat tagaaaaaat 24120
gtttcatatt tttttttttt tttaacattg tttcatattt gttttgtatg tgttttctat 24180
gcagatttgt ataaatttgt caatattttc atattgataa gaattaaaaa ttatggaaga 24240
gctaatatat aactatcact tgtatgtact atgtaaatag ttgacaatgc ttacgtagat 24300
aacgaaatta acattgagaa aattacaatt caacaactac attgtaccat agaaattaga 24360
aacaaatggg atactttttg aaatagaaga taatatattt ttggtatctt cggcggaaga 24420
agaccttctt cattatttat ttgttatggc taggttgggc tactaattca tttctctgtt 24480
taggtagaca atatttaaaa catatggctt acattcagat ttgcattcac atttacagtt 24540
aaattaacat ttttatcatg cagtatatgt ttatttatat taacattaat gaagtcaaga 24600
aactgaaatt tgaaaggagg gaaaatatgc acctcccaac ctacaacaat ttatcagact 24660
gactacattc tcgtggtagg gttcgtcatt tttgttaatg tcttattttc ttaaagaaaa 24720
tcaagacgat tcatgggagc tattgcctta tagtcaatga tcgttgttga atggttattt 24780
cagatctaat tatatggtac gtatgatatc actagacatg atcttatact atcatcgtca 24840
cattaattga tactactcgt taagaaatgt tttttttcgt tctcctgtag catagtcaac 24900
tcggacccta ttgatatact cttgcatatg taatcataat aatgcatttt tttttgttat 24960
atacaatgat gatcatgagt ccatgttgag ttactagaaa tataatgaat agttaacaag 25020
tgggtcgagt cattttcagc aatatatgtt ttttttctct acattgagtt agttttagga 25080
aacatttcta gaatcctctt tttaaaggag aacttgaaaa tgaataatca aaacattgaa 25140
aaatcggtga actcagatca ttgaagctac caatttcaat ggaatgataa tgaggcctat 25200
ataatattca tacactgatc attgatcgat tttttcgcca gactccaatt ttatgtataa 25260
caacatgaat tgtaactttt tcacattttt cagtctctaa tcaaacatat caacaagcac 25320
ttgcatgatg agtgatgaat agtgacattt ttcacataca ctgtgcacac agtaactaaa 25380
gatcattgct ttctcatttc cactttggtc ttggttgaag taattttatt tagtttctga 25440
aggttgaatt gtttggaaaa aaaaaaaatg atctccaaaa catgttattt tgcatggatt 25500
gaaaaaagca tataaccata gcaaaatagc tgttaatata aaaatgtatg gttttgagtt 25560
tcttttgact ataatttata gctcagtttt cacaatctcc ataatattga tcacaatctc 25620
cacaatcaaa ctttttatta ttagagtgta tagttaagca aaatcccaaa aataaaaaac 25680
ctagctagga aaatattcct ctaaattaat attacacact agttctaaac aatctgatac 25740
gagttgccat cgagatttgc acacgaaaaa tgttcaaagg gacccttttt tcatctttaa 25800
tctttttgga ctttggtcgg cgttggctga ttatgactcg ctataccacg atttctgtcc 25860
cttgttacaa ataattctat tagctagtct cgattctctt ttttctttct tcttttgttt 25920
aagtaacctc cttatctttc ttgtttagtg gaatacaggc tccgatcaaa ttcagtcaca 25980
tgtcatcatt tctctaagat atatgtttcc acgtcaacaa ttaatttcag ttagtttgtt 26040
tttatgtgtt tatataatac gtaataaata cataaactat aatttaaaca agatgaggat 26100
ttaaaccagc ccctagtaat aatctaacat taaaacaaaa agtaataaca taacaacgat 26160
acaaaaaaaa aaaaaatata attacaaatt ttggtattaa aattattttt tctatacatt 26220
aaatatggaa aaaatatttc tcataaaaat atatgtaaat atgtaaaaat tcaatcatcc 26280
ttatatatta tgttaatttc ctttagagtt taaggaaata gttttcgatg gttcatgtat 26340
ttctcatttt atatcatatt atcacttcgt caaaactata taaaaagtta aatggtacga 26400
aaataattcg tacttaaaac acataataat gggacataca ccacatatca ccaaaaatat 26460
taataataat gggacatgca tagaaggaaa aaaaacataa aaactgagga ctgttttgat 26520
gaaaacaaga agaagcctaa aatggaattc gtaggatatt acattgaaaa atatgactgt 26580
aataaattta agaggatatc acttcaaaca cttagttaaa aaccgactat agtacatcct 26640
attctttgac tttatctagt tatatttagt atttacattt gtataccgtc tatatatgcc 26700
caaaacatgt gaaactattt ttaatataga agtgaagatg tgtccccaat aattaatgaa 26760
tcacatatac gtttttcaac ctaaatgtga attatttcgt taattttggg aaatcaagtt 26820
tttttctgtt tccaaagcat atcttataaa ctcacttttt gttttgataa tatataggca 26880
cctatttgcg aacaaatttt tattatgtac acagtacact caaaagcttt atgtagttat 26940
tatcattgtt atagtgccta agttgctgct tatctaacta tccactaagt tttttagttt 27000
ggtctatatc ttagctatta actttagtcg agatcattta actactatgg cggcttgaca 27060
gactgaggct attctttaat gaaaaactct ataatgtaaa attctttttc ttagtcatat 27120
agaattatag atatctatcg tggtttcaaa ctttcaatct atatagtata taagtgtata 27180
agtgacatta tctaaacatg tttatatcct caaagttgta aagttactaa acttccgaaa 27240
agatgataga aatagcaacc agaaaaacta tattgtattg acttttgact gactttagaa 27300
ctcaatagtg taggccaact caacctaaca ttaaatattt atgaagacta attaacaaca 27360
atcataggga gcctattaaa atgttaaagt cttgcgcatg tttgactata taatactaac 27420
gtatagttgc atttatttca atgatataaa tattttatat ctcattgtac tacttaagtt 27480
atagattgat tattcgttgg tgatatttaa gaccaaatcc taagacgaca tatatatgta 27540
agtgtaaccc aaaaaaatct aaaagtcata aaccgtatga ttataagtat atataagata 27600
cgtattatac tacagaaaca cacacatgtg taacggacca acatggatga agaaatggtc 27660
ccattgagaa gaagagatct aatgacttca aatcaagaat ggtccatttt ccaaaataga 27720
cacgtaaata tatacaaagc ttaatcccca tccctctatt gggtctacac acagcctagc 27780
atttttgtat tttctgctct gtttttattt ttttttaact ttacaaatta ctttttaatt 27840
cttattatct tcagcttttg ttctgtcttt ttttttattt tcctgataaa ttctcacaac 27900
ttccattcat gactcgagct gggtcctttg atttgtcaca gctaatcaaa acagtattag 27960
cacaaaaaag tgtatatcaa tatgaccatg aagttcataa aaacatggga cctttgaaag 28020
atgttgtctc acatattcat acatatttca ataaaatcca ttacgtacga ttccatataa 28080
attattggtc agtcatgcta aatgtaagca agcaaacata tcatttatgg tgttacatca 28140
agttatgaca gagtatgatt gaggccagaa agtaacttat gggtctaatg gatcgtattc 28200
caaagtaatg ggctttttat taaggccgta agaggcccat ttatgtgatt tctttgaagt 28260
cgctttgttt gcaagttgcg actactcagt ttcttctccg gcgaagaaga ggataacgaa 28320
aagaaaacac atagctatga acggagcttc gctctgcaac tccgttttgc ttcattctca 28380
ttctctctct cgttttcagt catcctcttc ttcttgttct gtgtatctga tttcttctgc 28440
gcgtactacg tctaagtata tctcaatttc tcatagaatt cgacagagct ttcgagaagt 28500
tattgaaaaa aggagtaatg ggttttgttc attcgctgta aacaagcgta gaagtggcga 28560
ttccgttatt gtggagtcag acgatgatga tgaagaagat gatgaagatt ggggtgaatt 28620
tgatggagaa gatgaaggag aagaagaaga agaagatgaa ggagagttct taccaatgga 28680
taagatgaag aaatggttag agaaaaagcc tcgtggattt ggtttaggta aaaagtacga 28740
aactttaatt gaagataagt tgctcgacga aattgagcaa agttggaaag ctcaagctgc 28800
taatctcaat aagcttaaga atgatcctct caagtctcaa cagcttaagc gtgacgataa 28860
tctcctcaaa ggtttcgtct tttcttcttt tttttgttaa ttgagttata gtttggaatc 28920
ttatttagct ttgttgtgtt gtaaaggaac tggagaaact caaattgggt ttcgtgttcg 28980
tgtgactaat cttcctaaga agaagaatgt tcatagagat cttaaggttg cgtttaaaga 29040
agtaagtggc gttttgagta taacaccagc tgtgtctggg aataagaaga ctaaggatcc 29100
tgtgtgtaaa ggatttgctc atgttgattt caaaactgag attgatgcaa acaggtatga 29160
gacttgtggt gtttatagtt aagtggtaat gaggcaaagt tttgattttt ttctcttagg 29220
tttgtgaaac agttcacggg acagagctta gcatttggga aggttataaa gcaaatcaaa 29280
tgtcaggttg tggagtttac ttctgatgat tctgtatcga aggaagtgta cttagataac 29340
ggtttcaagg tgcagaagct tccgtattct ggtcttgaag gagattctag tgctgatgtt 29400
gttgaagaag aggttttgtt gggttcaggg gaagaatcgg atgattcaga agaagaggta 29460
gatgaaagag aagtggaaga cgatgagcgg aatcatatct ctagtagcat agaatcttct 29520
cccattgaaa tgacacgtga ttcgaatacc aagttaaagt ttgagaaaca agttgtgaag 29580
cgagagataa gagaacatga ggaactagag acacctttag tttcattcca ggtgaataaa 29640
tctgaggaag ctgcagcgga aacacacttg gatgatgaac aatctgagga agctgtagca 29700
gaaacactct tgaatgatga acttgatggg gatgatgaag aagaagttgc tgaagacaat 29760
cttgaacctc tgaacagttc attgtcatcc tcagaagaaa atagagtaga tagaatccgt 29820
aggctagagc aaaagcttct cggtaaagaa aaactcttgg gtggaggagt tggctttgat 29880
aaaccagaag caaaacccgc tagagttgaa ggaaagaaga aggagaaaaa gaagaagaca 29940
aagattcttg tgaaaggcca agccaaaaag gggacaaaga tagaaatccc tggatcatca 30000
aagaggtaaa gagcatacag caatttttgc taatcaatgt agaatctcta ctcaaattga 30060
ttgatttcga caattatgat tcacaggtta aaggtgaagg agaaggctct attaactggc 30120
gtcttagtca agtatgcggc taaagttgct tcaacctcaa acaatgatga atgatatcat 30180
taacaagtga tcaaattttg atataatctt tcatcaactg ctagtagtga gccatcttcg 30240
atttgttttt ataaaagtgt tacatgaata ggtgataacg ttacgtgggg aaatgctatt 30300
ttttctttct acatcttcat caatttgtgg agacagcaac gttcataaac tacattttca 30360
gacttaaaaa ttgaaacttg gcaggtaata caaaccggat tttcactcgg cttttaatcg 30420
gtttcaattt cggattagag aaaactctaa ccagagttgt atgaattcat tcaataatat 30480
gttttttttc ttgctgaagt ttcattcaat aaagttactg ttccaacttc aagaaaactt 30540
gtaatgaagt gcggttactg catctatcat atattctagt tcaaaacaaa tatgagacat 30600
atttctgata gagcataggc tctcgtgtga cctcctccga gccagataat gtctatcaaa 30660
ttcttgcgtc actggacgaa catccttcag cttcctggtc cagttgcttc cctgaaagag 30720
ctcgctaatc cgaagcctac atccataagt gtttttttgg gtgtataaca acagtattca 30780
taggtgactc tagaccagaa agcaaacatg ctttataaag tttagtggtt catcaaaggg 30840
aaatccaggt ctagctgaca caggagcagt attaaaaact aagaacagaa gagtggtatg 30900
aagttatcgt tacaatgtta agaaaacttg taatgaagtg aagtttctgc atccatatcc 30960
aatcagactt gtaaactgca tcaaggtcta ggaaatagct acaaacaacg tagctgaata 31020
tcgcggattc atcttacgat tgaagtatcc cattgaaaga ggttacaaga ttaagaactt 31080
agaatcattt gaccctgacc aattgtctat aattctgaat caaatcgttt ctacttaatg 31140
caatgctact caaagatcat gatatcaaca aaaccgatat gaaggagcca aagcaacaag 31200
ctttgattag aaatgaacaa agttctgcgc caagatcaaa agcaacacac taaaacaaag 31260
tctacacttc tattattcag cgatacattc ttgaactaac aaagatccat ctctcaacaa 31320
aaccaattta gcaatgagaa agaaagagca agtgtaacaa ctatgaccct ttataaaacc 31380
ttaatcagct ttgtatcttg agctcataca cggaacaaaa gcagaaaaat cgaaccttta 31440
gatgatcact ccaacacaac tttagcacca agtgctttca acttctcaag aatcttctca 31500
ccttcttctt tagacaaacc agctttcaaa atagcaggag tcttctcaac caaagcttta 31560
gcttctttca aacccaaatc agtaaaactc cttaactctt taataatctt aatcttagca 31620
gatgcttcaa aagactccaa ctttatctca aacactgtct tctccacttt agcttcttca 31680
ctcacaccac tttgactcac catcccacca ccaccaccaa caccaacacc accaccagct 31740
ccaggtttca taacagcgac tgttggtaac tccgtcatac ctttcttctt cattataatc 31800
gaaccaagct cggagatttc taataatgtt agagatgaga tctcgtctac gagtctgaat 31860
acacgatccg ttggtggact tcgatgctct gttggatcaa aagtagctgg atcgtaatct 31920
gttgggagct ttctctgatc gaattcttct tcttcttcat cttcaatctt cgccggttgg 31980
gtgtaactcc ggtaaccgcc gattcgagaa agaagtgata atctggatga ggtttgagat 32040
aaatgttgcc tgaatctgag aactaagctc atctttaagc acttcttcaa aagctctatt 32100
atgagttcac agatttgaaa aacagagcaa tggtaacgaa ttggggtttt tggttcatct 32160
ggagaagatg ccctaaacag agagacattg ggaagagtct ctctgatcag ataaaatatc 32220
taaaagccca ataaaaatag gctaggcccg attagtatac tttttggccc aaaacgtttt 32280
cttaaaaaca attgtattta cgtttgtttg ttaaattggt aaaaagctac agtaaaagat 32340
ttctaaaata aatcaaatac tagactatca tatatttata gaaaatatta gattcataag 32400
aaataaaaaa aactatacat taattgacat gtggttcaac cggaccgaac gattgaccca 32460
atgacccaaa agagttacag ttcaccttct gatccggttt taaaaatatt ggtaataata 32520
actaatagat ttaaataata acaaacaaac tattatttat tcaaataaat cttgtcaata 32580
atggaagata aaaattgtcc aatataattg aaacttatta tcttcaagag cttattactt 32640
tggtggtgta gtgtgattga tagaaattgg taagttaatc ttacaacaat aaaatatgga 32700
aaaagctaac acaacaaatt tgtcgttagg caattttaca aagaaatagc aaatgattta 32760
ttgcccttag taaacatctg acttacaagc tctaacgtat aaataattcc aaattttcaa 32820
ctaaacaatt gttgggccca ctcgaaagca ggaccctcca aaaataggcg tatgccactt 32880
agcgtggaga gcacacggta ttctttagta aaaggcgaaa gaatagttcg ctttgtgctc 32940
accacatggc tgcgtgatta taatcgaagg accaaggcct tgttttatat gcatctttct 33000
cttggaacaa actctcagct tagcgatgtg ggactttttc tcaaactatt tcttttactc 33060
ttacgcggtc gtttctctct attgttgttt tattccacaa caggtaatat ctatttcact 33120
gctaattaca aatgtttctg actcgagttc taattctttt ttttcacact cacaaatctt 33180
ctttacacaa ttcaaacata tgttcttaat cttctaattg cgaatcctaa tagtctacta 33240
cgagaatcaa tggagttgga cttacatggt caacgtaaat gacagataaa aacctatttt 33300
actttcacgt tgagattcag agatatatac caaccaaaag agtgtttgga ttacaccaaa 33360
acaccgtcga catttcacaa ttaggctgtg cttgggttaa caaattgtat accagaaaaa 33420
gaaaaaatcc ataacagaga gaattacaaa agaaagttct gctgcctaca atcatccgga 33480
gagaaaagtt tcgggttgga tctcaaaaaa gttatcatag tttcgacccg catagaggct 33540
aacaagacca aaaagagtga gaagcagcta gaggcgagat ccgttcattg ctaccttgtt 33600
ggaagggacg ctatagcctg aagaatcttc ttccttggac cctgcattgc atcaatagag 33660
tgataccaac ttcaagaaat ctactaaaag aacagatcaa tctcaattgt tttcgatcga 33720
taagaaacaa aaggaaagta ccattggtat gatgagatct tttagatcac tttctttcat 33780
ctgctttatt gtggtcatat ccacctgttg tcatattagt caagtttgtt attgaagaac 33840
aatgacgaaa cagagctcag acaaaaaact aacatggaaa agcaataacg aacctacaat 33900
agccaaaatc acaaagctct aagataagaa aataatggta cacttacttc ctctctctta 33960
aaggcaaggg agtattttcc aagtccaatt gaatttagaa agccatcaac tgatagaggc 34020
tcgtccacct gttgttccac caagtagata tacatgccat attataacat atgtataaga 34080
agaaggcata aagttttgac tatctgatca caaaggtttt atgggtctaa gaatgacacg 34140
aggtaaatat gaagtactca cccaatgtat agaaagagta agaagagaga aaattcatcc 34200
acaaattgag aagaagaata aagatcttac agagaaggga ctgttctgca taatacttcc 34260
aagtggagga agctggctca atggaggcaa tggatgtggg tttgggactg gaggaggtaa 34320
cattggcctg gcgaaaggag caccacttga tggcgcttga ccatttagta cacctctaac 34380
aggatatggc gatgctctca tattatcaag catcctgctt cgtccatgaa aatcttcaat 34440
gttactacgt gggggagaac ccctggaaga acccatgtag cttctaggat tcctaggagg 34500
ggaaaaaccc tgagaagaac tcatgtagct tcccatattt ctagctgggg acagagccct 34560
agaattacta ctgaagcttc tggtgctcct tggcggtgac tgatcccttg gagggcccat 34620
tctccttcca gcatttcttg gaggtgatct atcccttgga ctgccagtta cccttccagc 34680
atttcttggc ggtgactgat cccttggagg gccaaatctc cttccagcat ctcttggagg 34740
tgatatatcc cttggactgc caattatcct tccatcactt cttggaggtg atctatccct 34800
tgcactgcca atcatccttc taccatttct tggaggggaa ggttcccttg gaatgccaat 34860
gaaacttcca gcatttcttg gcggcgatcg acccctggaa gtatccacaa atctctctgg 34920
agaccttcgt cgtaaatctt ccagagccca tgcagggtgc gaactacttg atgaaatcat 34980
ctgagaggaa ccacgagcag ttcttgatga agataaagga cgatccctcg gctcagccat 35040
acgaggtctt gtatcaaggc tacgaggagg ctgctcactc cttgagagct tttcacgaag 35100
atccatagtg cagccttcat cgctctgagc tcgtctctgg gcattctttt gcatcagttt 35160
gaatcggaga tcatttcgac tgatctgcaa atcttagtaa caaagagggg tgggtcagaa 35220
atcagcaaac atgcgctagt gtgtatccag taattcacat ctataccatt tccactgaaa 35280
cttgcttccc ctctttgcct gcataaacaa agaaaaccaa aaactttaat ctagtgtacc 35340
ttgcagcaac aagtaaccaa attcaaaacc cataaaaccg aagcatagaa cacacaatcc 35400
atcagttcct ccagagttct caatactcat ctattcacaa ccccgtgaac aaacaaaaaa 35460
ggtcctagat atcatgataa taagagcaac atcacagatt aagaagctcc tgacaatcaa 35520
tatgcagcag tagtacacat aagagggaaa aagttaacac cttttactga ccacctcttc 35580
tccaccataa acagaactat ctaacggatt ccctaatctc tctttgacag accgcttagt 35640
cccaactcta ggtaactcat acccatcatc tatatcactt gcagctcgat tcaccacctg 35700
caaaagaaaa acatcaccaa aataagcact tttctagact caaaaactca ttaaatccta 35760
caccaactca tctctataaa acaattctaa agctttcatt ttccagattc accaaatcaa 35820
actcctttaa cacaaaaact gagagatgag accttcaacg tacctgaccg ctacgaccta 35880
gagttatagt aaccctactc cgtctcgaac cttccgacat ttgtgaaaac cctaggaaaa 35940
tcaactggag ccaattctaa cttacagtga tataaaacca caaacaacga aagacaccac 36000
aatcacctcc ttcaaaccct aatcgtacga agccgaatct actcaaaaat cacagaaaga 36060
gagtaaacag gttcctgtaa aaaaggtata atagaatata ccataagatt ccgggggaaa 36120
attccgatga gattcaaaac gggaaaaaaa aaaacaaatc ggaaaagtat taaaatacgt 36180
gaagaatcgg tggagacgaa gaagacgttc gtgacgacgg actcttgctt gggctttgaa 36240
agtgctgcgc agtgccaaac caaagagacc tgactcatct agtggcttct tcacatgctc 36300
tcatcaatcg ctacgcaaat tttacgagat aggtttggat ttttcattat tttcacgttt 36360
gaccccatag ttcttttata attatcatgt ccttttttgg gaaattaaat cgaagcgtat 36420
aataataata aaaaatttaa taaaaatgag actgttatat attattaaaa tatataggta 36480
ttaacttatc gatatataaa gtagtccaaa aaattgattt tagaaccgta aatttaacaa 36540
agctcaaaat gtatgatgaa cttaaatggt aaaaaagagc acaagtttgt ttgtgggttt 36600
atgtgtccta tcaccggata agtcctataa cttgactaaa cattcactat ctgataaaca 36660
ttcactatat atccaaatcc aacaattcca cccatcttcg tttcctcatt ttttttttga 36720
tttatacact tgcagtttgt gaacatttaa actttctcaa aaatatattg ccggaaattg 36780
gtaaacagtt catcgaaaaa accgtcagaa atgttttagt ttaacaagtt ttctacatag 36840
atatattccg actaatatcc aacaaatatt tttatgaagt ggtaatcaac aagggacgat 36900
gataaggaga gggatccatc ccgtttgtcc aagaagagag tcaaagttct aatttgcaat 36960
catacgaggg aaaaatatca aaaaatccaa gagaattatc tccaatataa aacagagttt 37020
ttttagacga taatagagga ttgaaggtaa tagatcctaa agtgatgaac aattgttaac 37080
ttgttgccgc actaagatca ctctcaacag attcaagcac ataggtgatg aaacagagct 37140
gaatcgatgg agactcttca actagactac taaggtcatt atattctttg aaatttccag 37200
tggatgattg atgagtcgat cgtaacaata tggatcgaga gacgtcacac aaaagatgga 37260
atatctatga taagttaagg acacccaagc ttcaagggtt cacacacaag aacgcgctaa 37320
aatgtttggg taaagaaagc taagaaaatg tataacacga aatcaaacat aggtatagga 37380
cataaagtaa tttatataca agtagtatat gtgaaatcaa aaactgtaga aaaggaacca 37440
atgtctaaat atgtgtgtat atatatcccc atcctttaat aaaaaaagaa taagatatga 37500
ggtaaatcaa actaaaagaa ttgaagtaag aaaaaaaaaa ctttatctac ggtaagaacc 37560
acaagaccaa tccgacggtt gacaacaaga gactaacaat tgttgatctc gatgaaccgt 37620
cgattctcca ggcggcactg aagccaccag tgtctcgctg gtgtttagtg gtcgacggtg 37680
gagatgttgt gccgttgaag ttagggtttg caccgtacaa gtattggatt ccttccacgt 37740
catcattggt taagtcaacc ttacgtttcc ctgtcgtgat cgttggatac atgatggatt 37800
cctcaactga agaatgtcct aaacctagaa gatgaccgat ctcgtgaacc gccactgatt 37860
caagatcaac cgcagcagtt acggagagga aactgtctag gtctccggag accacccagt 37920
tctcatctgc gtctaggtgg aatttcccgc tgggaggaga gaaagcgtga gctaatgttc 37980
ccaaaacgcc gtcgaaaggc tctccgtcac catggtcgcc ggtgtagaat ccgattgtga 38040
tgtcagacgt cgagaaagac tcggaaagag tgaagtttaa cgcggtgacg tcagaccaac 38100
gaccaaaagc gcgtgagaac acgctcttga cctcttccgt caacgggttt ttcgggtcga 38160
acgcgtaggt caagtcacgg cggtttctcg gccaccgtgg ctcgcctggg aataacgtgt 38220
agcgtttaac cgcgtgcaaa tgcgtgcggg agaagttgac ctcgaaggtc tttcttctcc 38280
cgccatgcat caacgaagta ccgttgacca cgtcaggatt accgcaacgc gggatcacga 38340
tgtgttgaat ggtaagcgca tcaagctcac cggtaacgtt aagattgaaa ttcgtctgat 38400
acaattcgac agcggctttg aggatatcat caaaatcatc ggtgaaattt cccgaaaacg 38460
tttcagggat gtaaccaaaa cgttggaagt attttttgat acggtagaga ccatcaacgt 38520
tttggccgtg gtgacaaccg gtgaaattgg agaaagcgtc ccagaaaaca cgtgtagtgt 38580
tacgtagaga cggtggtacc gcggtggagt tagggaagaa ccaggcggag gcaggagaaa 38640
caatcaagaa aagcgataaa aacccgaaaa cacaaaacct catggtggtt ttcggattat 38700
aggtagccac ccaaaaaaga agaaaagaaa caaatggaga aggtaatatt taggatttta 38760
ggagagaatt tgagagagag aagagagatt aaagctaaaa aacaggtaaa gccgtttaga 38820
agatggtttt aaatataaga tatataaatc gaggtctgcg tttgcgtttt gtgttggcgg 38880
gtgagaggtc gttggaatcg tttgcgtgtc ttttgtcaat tttctagttt ttaattaaga 38940
agaaaaatgg tgaatgattc caatggaaac atctattggt cttagtcacg ttcaaactta 39000
tggatgttat tggtttgtga tttatatgga tttttaatga tttataatat taggaagaat 39060
catttgttat tcaattaaga ttgtttaaga ttattaaaat ttaatgttat tagtttctga 39120
tttgtaaaat gtaatctaaa atctttataa atttggagtt attgaattca tactttagta 39180
aagtcattga attttttgtg ttattcaatt aaaacaaaag tattaggatt gttaatgatt 39240
taaattattg tgttattggt ttatgatttt atacattttt cttcacaaaa taaaatcata 39300
aaaagtatca taagaataga gagattgtga atgattttta gaattgacat ggatcatctt 39360
cttacccatt aaataaaaac caatctatgt aacgttatga catctctcta atcttttcaa 39420
gaaatatcat gaacgtaact tttaaaccct ctctctaatc tttctatata attatgaact 39480
atgtgtaaat tttttatatg agaacttaag tacctctaaa ctttaacaaa agcacagtaa 39540
aatattttgg gagagtagta cacttttgac atatacaaaa cctatgtaga acttttctac 39600
gagacaattt tataaaatat gaaagaaaca atatttcaaa tagataaaat ctcaagtaat 39660
catttcaaat ctttttaagt taggaagact ttacaagatt acggaaaagc taatcaaaga 39720
gattatacaa aactctctaa taatcattta aaatctttga ttttatctat tatttatatt 39780
cttttaaaat tattaaaact ctttcaaagt tagaaaccaa taacacccgt taaatagagg 39840
tcatcaagat taaagaagac ttgtgcaact gaaagacttg gctccggttt aaaccggttt 39900
gatggagctg aaggtggcgg agtcaaataa agacgttgaa ctaagttttg ctttttgttt 39960
agtttcaagt tggagttggt ttggtcggga aagtcatcaa ccaatcttca acttacacgt 40020
ttttaaggac gtcacaattt ggtagcttcc tggtaaataa tccataatca taggtaaggt 40080
tggtccattt aaatactttg tttccacttc caagtcattg ttgacaaatt cttactattg 40140
aagaatgaag cagagctagg taccaaggag ataacattga atatgataag agcatcatat 40200
aatatattca cacgaagatt gtactaaaaa cgtggtttac tttccctcta actaaaaggg 40260
taagcttaaa tatataaacc aaaagtatac aaacacaaac agacagaggg agagagatag 40320
acatacatgt taattaactt tgctaacact tagaaggtct ctcataatta ggaggtaaag 40380
aaggacaatt ctggttcatg tttggatatg ggtaaatggt gttataacca ggtaactcca 40440
ttctgtattc acctagaatt tgacagaagt caagcttccc ttcctcggtg ttgcaccaac 40500
tcggtaaccg agtctggtta gactcaaata acttcagagt gtacgcatct cggatctgaa 40560
aatacgaaag aagataaacg ttcatgagta atgttaatgg aaagatttga tattgaaaag 40620
aaaaaaaaag aaactcacag tgaattcagt gacttgaatg tgatcagcga gagggtcgaa 40680
tataccagca gctttgtaca ttgcaaggat gaaagcaaca catgttgtcg atttaccgtc 40740
gctataaacc cactcatcct gttcagggat ggtgagtaac tcatcaaatg acattccacg 40800
cctcgctgtt tcttcaagta tcccatacaa atccagatcc tgtacaacgg aaacttatta 40860
gttagcctgt acgtcctaat ctgaagaaca atagaaactg gatattgtac ctcagtaccg 40920
agtcgtttat taagtgcctc gttccacata ttagcagcat atgcaggttg tacacgagtc 40980
cacatagaca tgacagaaat aacctgaaag ttcaatgtgg cttgttgatt accatgatga 41040
tcttaatgat gatagatctt taagaatatc agggattaaa aagtaccaag tgagcatcaa 41100
ggggaggggg gtagttatcg cctagagtgt cgatccagct gaatatcatg ttgtgatatc 41160
catacggttt gcccaacata ctccgtgcat attcccacgc agcagtattg ttgaactttg 41220
cccggatatc aggatgtaga ggaagcaaag ctacttgagg atttgaatta tccttcaaag 41280
tcagctccca ccattcatcc caagggatca caacaatgat ttcttcaccc tatggggaaa 41340
aagatagtaa aatatctctc tttctatcca ctaacttcaa aatgtttagg tctacctttt 41400
cgttctcatg tcctgattca ccaacccaaa gattccccaa atcatccttc aaacaaacag 41460
cagtatgacc agcaaaagcc ccagtcaccc atttctctaa cgtctcaaaa ccaccccatc 41520
tacctcgaat cttcgacacc gccaagaaat caccagaatg cacatcttct gggttaatca 41580
ttgaccgcca aggttgagac cgtttctcaa aggtagcacc catatgtttc gtcaagaacg 41640
ccaaattcgc attctgtccc caagcagtat tggagaaaag aggtaacaca tcaatcaaag 41700
atagcaacgt cccaagcatt cctgatggca ttagaaacac tgaaacgcca tgctccttca 41760
cctactcatc gaagaaatca ccatgaaaac aaacaccaca aaccctctta agactataaa 41820
gaagattaac taaatcaaaa acctacatat tccaattcag ctttctcttc ccaagaatca 41880
aagttcaaag tatgatctct agcagagaaa tagtagtccc aagtgatcct gtatggcgtt 41940
gcaaacacat aaagatccat acatgtcaag ctatgtgcct tggatgtctg caaaattagt 42000
tcccaaatgt tatcaaacaa ctcaatttca tccagaataa catacaattt cgaattagca 42060
gcaactacac aacagtctcc taattttgaa tttgttacca taaaaggaaa aactttacga 42120
aatctgagca tatgagcgtt gaaagtataa cactttaaca ttaagaagac aaattaagaa 42180
caaattgatg aagaagaaag tgaaattaac caactttgag atgaagaaca ccaccaccaa 42240
gtccagggac gtcacgatca ctaccggtga tatcaagacg agcttcatta ccattaaagc 42300
aagcaccttt ccactcaata gatacattat taggagtaac tgacccaata aaaaccggca 42360
acaaatccac agcgttgtgg aaactgttca aaacaggcca tgagacttga cgaggtagca 42420
tcggaagaac atcgttaacg ctgaaaggaa ctttcaggga ttgacccagg tcaacgcaaa 42480
aacctaaccc tagacataag aggaagaaga gtgatgggtt ctgagacatt cggatccacg 42540
aagtgaaatt ttgagacttt gtttcaaggt tttggggatt ttggagaaga agggtttcgt 42600
gttgttatgg ttgaagatga tgatccattt gggatgtttc agtttttttt ctctctgtgt 42660
gttttggatt ttttggaaaa ttggactttg ggggagataa aatattgagt tagttttgga 42720
tgtggaagaa atcgaccaaa ctggttttag acttttctta gaaacaagaa gtttgaagat 42780
tctttgcttt ggtttcatct tccacgtaga cacaaacttg gtttgtgaat gaatatctcc 42840
aagaaccgga ttttaccatc tggttcagtt tggttcattg ttcaattgct catgacatct 42900
gacaaagata attgcaaagt ttcacttgaa atgactaatg ctatatgata tatagcataa 42960
tattcaccta agactacaat gattgtatgt atgcacttga tggtcctatc cacataaata 43020
actacaacaa ccaataacaa aatgatgtga cattttctac attcattgta tagataatgt 43080
tggtccatac accggaacag tatctctatc gtcgatccag accataacag tgaaccattg 43140
agttgatcaa taatgttgga gaatttttac attgcgaaga tgaaacagtt tgagtagcaa 43200
gggataaaca gagtactctc ctctactgcc attggctgtc taaatggatt caactcaatc 43260
tgcatttcaa agatacatcg ttacattcat atcaatatga ttctgaagaa atatataaga 43320
atttatctgc aaaacatcat tttccaacaa aggttgattg gagaagtgga caatagtgtg 43380
tctgttttgt gtggccccaa agatgaagaa aaaagagatg tttttgtctc cttcaacttc 43440
attatatagt atatgtgtcg actctctatt ctacgtatac agttttgatg agacataagc 43500
ctgactatat gcaggaggaa cccacatatc aataaacata gacttgaaat agttaaatag 43560
gacaatgaac ctataattta gacttacagg tgatgataga ggttgtcctg tgatggtttt 43620
aatgcaacaa gcagccagat gacaagcttc ttcacagtaa tcagagaata ctgctgggac 43680
ttgtatctcc tttatcagtt cctgaaatta ttcacaccaa cacatgaatg aataacaaac 43740
atatgctctc tctgtgtatc ctgggaacta ttggatgtga cattagctac tggaaaaacg 43800
tacaatagtt ggcaaccagc ttggatatgc agcgatgcct gcgtttggag caatcactat 43860
gtgtggagga aatgaatcct gccgagatgg tcaatcagaa attattacat cttttaggaa 43920
acaaacaatt caaggtccac gaaaatggac attacatata agaacagtat agtaaatcat 43980
tgttttgccc ctagactagt agaaaggggt acctttgtta tgtcattgta acgatcatgg 44040
taaaaccctc tacggagctg taatgacaca gccgaaacca aagcaggttt gctcccggaa 44100
ttgagaattt tgcttgaatt tttacattca cattcttttc ccatgcaagg ggaatatctg 44160
caaagggaga tcatttctcc atccctgttc atcgagaaag caaatagaga acgatccatc 44220
aaattatgtc aatagttcaa cacatacaaa gaaaatccag ctataatgtt gtcactgaat 44280
agcttaaaga actctaaaga agagtgatta aaaggaaaaa catatcttta ctcttcctaa 44340
ctaaaataga actagtgtta tacaaagtaa tcaaatagat tgtggaatgc aggactcaca 44400
tatgttgtgg aacgtcaggt ccaatcaaat ctacataaat gcgcagacca gggaagagcg 44460
cttgcagctc agcaaaaaca ccaagttgcc caagttcctt ctgaggccct tcagaagctc 44520
aaactatcag caaatcatat atcagaattt tacaccatag tggttctgat gattcttttg 44580
ccaatattaa gggactaaac taatataaag gaagtggagg caattaacaa aaactgccta 44640
acagaacaac gagaacatga tagcaacctc agagaggata cagttcctca aaaagcagaa 44700
gagttacaga gtgaaacata ccaagataat gtatacgaag ttcatcactt atttggggag 44760
tcaaatttcc catcccaatg gcttgaactg catgatatat cgtaagtggc tgaaataaaa 44820
gcaagctcta cgagtcaaaa aaaagaaaac ctcaagcatt ctaatcatac ttgaaatcac 44880
attactcatc agaaaaactg ttattaccca gtggagaagt agagctacag gtgaatctag 44940
aggtaacttt ctccactcga aataatcctt ccaagtacat agctgtttag ttattggaga 45000
taaaggccct gtgtaatcca aaatcagaac tctatagaaa caaactcttt cagtaaaacc 45060
ataaacagag aagtgaaaat gaagtatacc acgacatgga caagaagagc tcggcaaatg 45120
ccacccttca atattaaaac tgtcagaaaa agatagtagt cagctcaacc aacaatagct 45180
tcaaaccaaa acgtgattct cattaagtaa agagaaaaaa taagcaatga aacctatcaa 45240
aagccaaagc tccacagtta cactcataca tccacattcc aacacgatgt aatcccctct 45300
tgatgaagaa cgagcaccta gtctcatgtt tttgactaac ctaaagaacg aataaaccaa 45360
aaacttaaac tttgagctga atttttacta accaaaaggc atttgattcc tcactatcat 45420
tcaaagtgat gattaacctg aattgtagct tcttctgtaa atgtaaatgg aaaatcattt 45480
aaaagatcaa cacgacgcat ttgctcttct aatctctcac attcttcctt gtgatagctc 45540
caatgcgaaa tctacaaaca aaataaagat caacaaattc aacaaggaac atcctaattt 45600
gcttatccac ctaactacaa gcgaccgatc aaatcatcac tgtgaagaag aagaaggctt 45660
aagagagagt taaagcagaa gttaaaacct gatgagagac ggagcaataa gctacagcac 45720
cacactgacc acacctccgc gtcggtggac caacacaccg cgtcgcaaaa ccacgcgcgg 45780
cacactccat ccgccgtcga cgaccaagac aaccgccgtt tcttctcggg acgaaaaaag 45840
tattaaagaa tctcggtaac tcttaaggcc catttttcta atcataaggc ccaatgtttt 45900
cttatcgtaa agcccaatta gttcttatcg taagccacaa ttttgtttat cgcaaggccc 45960
attttgttct catattaaca atgttaacct agaaaaagta ttttgaacaa agaaaaaaaa 46020
cccctataaa aagtattaaa aaggactgat acaataatgt atataaatat cctaaaagat 46080
cttaattttg taaatttatt gttgtatatt ctaaacccgc aatattagaa tgatgattta 46140
gtaaacaaga aagacaaaat aaataattaa ttttagctag aaaagatgaa ataaacactc 46200
atgatttaag ccatacaaat cgaagcccct tgggttcagc atttctcacc aagtaaatac 46260
catcacctct ggaaacccat ttacgtactt gaccacatct tttattagcg gctcctctgt 46320
atgctctcca tatgttatac acactatgat gccttaagat ttattcacga cgatttaatc 46380
agatacgctt atggattgcc aaagatgatg ccatctactt agagaaaaac aatggaaagc 46440
gagaacgcat gtataattgg aataaaaatt aatatggttt tcatatatct aaaaaattgg 46500
acatttgaag ccttaataaa ttatactatg taaaaatact tgtttatgaa tgtaaattat 46560
aataaattac gatttaatta gggaaatatt gactatatat ttcacccaaa tattgaatgt 46620
aaattttatt ttccaatact tttgcacatt taagaaattt tcggatgtat ttcctaaaga 46680
atattacctt ttttgttttt taaaccatgc ctttttgttt tacacgttca taaatgcatg 46740
ttccatacgc attaccataa tttaatttga acttaatttt ctctaggaat ggtgatgatc 46800
cactaccact atcattgatt tcattccata ttcctttgac cgactgaaat tacgttggaa 46860
atagtatatt ttgatgaata atttatttac tcggaaaaaa gaggtcaagt tattaatagt 46920
aagtacatat acattatcaa ttaagaattc aattgagttt taaggaaaat cctattaatt 46980
tgtttggtat tcggtatttg ttagttctaa ggaattgaat ttcccgatta tacatcatta 47040
taacgttctc aagttccaaa cttgcaaccc acattttgtc gatattctca aatgtgaatt 47100
cattcaattt cccatagaaa acataaattt gcacttaaag ttaacaattg aaatcgtatc 47160
taaatgggaa tgtttttggc ttttagtgtt agacttccaa agcgtcaaaa atatttctag 47220
aaagagcaca aaaaataagc aacgccacta cttttggaca aagtcaacga taacacacat 47280
caaccgcacc agctccataa aagtccatct cacgaaaacg attctagtca aactacctaa 47340
aacaccctta tatttacata caacccaatc ccactaacaa gggtattttc gtcaatcaca 47400
aaatttatca ccgacccggg aagaagaaga agaacagatc aactaatttc tgctttcaac 47460
tccacattaa accaaaacct ccaaaaagaa tcatttattt aaattatctt cccgttttaa 47520
gttcctgaga tttttgggaa ttgtaaattt gaagaaaatt aaacaaagac gtgttttcat 47580
tttttttttt gtttccttta ttgatctctc tctatctctc taaatgagct aaatcgttaa 47640
tggctgccat gtttaatcat ccatggccta atttaaccct aatttacttc ttcttcatcg 47700
tcgttttacc attccaatca ctttctcaat ttgattctcc tcaaaatatc gaaactttct 47760
tccccatctc ttcactctcc cctgttccac caccgcttct tccaccttcg tcaaacccat 47820
ctccgccgtc gaataattca tcatcttcgg ataaaaaaac aatcaccaaa gctgtcctta 47880
taacagcagc aagtacttta cttgtagctg gagttttctt cttctgcctc caaagatgta 47940
tcatcgcacg gagacggaga gacagagttg gaccagtcag agtcgaaaac actttacctc 48000
cgtatcctcc tcctccgatg acgtcggcgg cggtgactac gactactttg gctagagaag 48060
gattcacgag gtttggtggt gtgaaaggtt tgattcttga tgagaatggt cttgatgtgt 48120
tgtattggag aaagctacag agtcagagag aaagaagtgg gagtttcagg aaacagatcg 48180
tcaccggaga agaagaagac gagaaagaag ttatttatta caagaacaag aagaaaacag 48240
agcccgttac agagattcct cttcttagag gaagatcatc tacttctcac agtgttatcc 48300
ataacgaaga tcatcagccg ccaccgcagg tgaaacagag tgaaccaaca ccaccaccgc 48360
caccaccgtc aattgcggtg aaacagagtg caccaacgcc atcgccacct cctccgatta 48420
agaagggttc ttcaccatcg ccaccgccac ctccaccggt gaaaaaggtt ggagctttat 48480
catcatcagc ttcgaaacca ccacctgcgc cggttagagg agcaagtgga ggagagactt 48540
cgaaacaagt aaagttgaag cctttacatt gggataaagt aaaccctgat tccgatcatt 48600
caatggtttg ggacaaaatc gatcgtggat cattcaggta tatatttatt tcgaaagtta 48660
gggcttttgc ttcaatcaat tgaaaaaacc ctaatttgtt tttgtttctt ctcagtttcg 48720
atggcgattt aatggaagct ctgtttggat acgttgccgt ggggaagaaa tcaccagaac 48780
aaggcgatga gaaaaaccct aaatcaacgc aaatattcat acttgatccg agaaagtctc 48840
aaaacacagc gattgtgctc aaatcattag gtatgacacg tgaagagctt gttgaatcac 48900
tcatagaagg aaacgatttc gtgccagaca ctcttgagag gttagctaga atagctccaa 48960
cgaaagaaga acaatcagcc attcttgaat tcgacggtga cacggcaaag cttgctgatg 49020
cggagacgtt tctgtttcat cttcttaaat ccgtgccaac cgcgtttacg agactaaacg 49080
cgtttctctt tagggctaat tattatccag agatggctca tcatagcaaa tgtttacaaa 49140
cgttggattt agcttgtaaa gagctgagat ctcgtggctt gtttgtgaag cttttggagg 49200
caatacttaa agctggaaac agaatgaacg cgggtaccgc gagaggaaac gctcaagcgt 49260
ttaatctaac cgcgcttttg aagctttcgg atgttaaaag cgttgatggg aagacttctt 49320
tgcttaactt tgtagtggag gaagttgtta gatcggaagg aaaacgttgt gttatgaata 49380
gaagaagcca tagcttaaca cgaagcggta gtagtaacta caatggtggt aatagtagtc 49440
ttcaggttat gtcgaaagaa gagcaagaga aagagtactt gaagcttggt ttaccagttg 49500
ttggtggatt gagctctgag ttttcaaacg tgaagaaagc tgcttgtgtg gactatgaaa 49560
cggttgttgc aacttgttct gctcttgcgg ttagagcgaa agatgcgaaa acggtgattg 49620
gagaatgtga agatggagaa ggagggaggt ttgtgaaaac gatgatgacg tttcttgatt 49680
cggtagagga agaggtgaaa atagcgaaag gtgaagagag gaaagtgatg gagcttgtga 49740
aacgtacaac ggattattat caagcaggag ctgttacaaa ggggaagaat ccacttcatt 49800
tgtttgttat cgttagagat tttcttgcca tggttgataa agtttgctta gatattatga 49860
gaaatatgca gaggaggaag gttggtagtc cgatatcgcc ttcttcgcag cggaatgcgg 49920
tgaaattccc ggttttgcct ccgaatttca tgtcggacag agcttggagt gattctggtg 49980
ggtcggattc tgatatgtga gagtcaagat ttgttatatg taaatactaa atagtagaag 50040
cattttgggt attgattagc attgaaagat gttgaattgt ttatagattt atcagtccaa 50100
agcattggac ttgagtataa tttgttcctt gtataaataa acaattttgc tttaagacct 50160
ttccatgttt atgaacatgt cttctttaac ttcacataga ccttttgttt acgtaagaac 50220
taataatact aaattgtttg ataattctaa atgtgaaagt gaaccactat atagtgtgaa 50280
cttggcttta ttgaattctt tttaaaaaaa tttctccaga gctttagatg taggagttaa 50340
tattttcacc taacatagcc tcttttttat gtttctctat caactaacac taaatttgtg 50400
gatgaagact aaattaacat aagtttatct attaactaac aacctaccag tttgatgctt 50460
gtaaatatga aacttcaacg ttataaagac tatatggtgt gaacttttta tccatcttta 50520
ttgactttta aaattttctt aatttgagta aacaaaagca gaagcttttt aaaggatgca 50580
ggagttgatt tttgtatatg aacaaaacat atacttctcc cttagacgaa tttggagcta 50640
tcattcttgg tttcaaactt tttaataatt tgagctttaa agcaaaatgg caactttata 50700
ttgatcacta gtccacaaca ctttctctgc cttttcctca atagcaacgc gtagtcaaga 50760
agaagaacgt gtttaacatg gaccaatctt gattaagata atagtatgat caaatgctta 50820
tataaacaca ctaaaaagga atcaaattta accattccac aaatcaccaa caaaatttaa 50880
tgaatcatgt ctctgcttct aaagatgtta ttattttcct tattcttctt ctatatggct 50940
tcaatttctc aatgctcaga cccaaccggt ggacagttta gcttcaacgg ttacttgtac 51000
accgatggag ttgcggatct aaacccggac ggtttgttca aactcataac ttcaaagaca 51060
caaggaggag ctggtcaagt tctttaccag ttcccactcc agttcaagaa ctcaccaaac 51120
ggcactgttt catccttctc caccactttc gtctttgcta tcgtcgcagt acgtaaaaca 51180
atcgccggtt gtggactttc cttcaacatc tctcctacaa aaggcttgaa ttcagttcca 51240
aatatcgacc actctaacca ttctgtttcg gttggatttc ataccgctaa aagcgataaa 51300
ccggatggtg aagatgtcaa cctcgttggt atcaatatcg atagctcgaa aatggataga 51360
aattgttcgg ctggttacta caaagatgat ggtagattgg tgaatctaga tattgcaagt 51420
gggaagccta tacaggtttg gattgagtat aacaactcaa ctaaacagct tgatgttaca 51480
atgcattcta ttaagatatc taaacctaag attcctctgc tttcgatgcg gaaagatctt 51540
tctccatatc tacatgagta tatgtacatt ggctttactt cagtgggaag tccaacttct 51600
tctcactaca ttcttggctg gagtttcaac aacaaaggag cagtttccga tataaatctc 51660
tctcgtcttc ctaaagtccc cgatgaagat caagaacggt cgttgagttc taagatcttg 51720
gcgattagtt taagtatttc aggagttaca ctagttatcg tcttgattct tggagttatg 51780
ttgttcttga agaggaagaa gttcttggaa gttattgagg actgggaggt gcagtttggt 51840
cctcataaat tcacttacaa agatctcttc atcgccacga aaggtttcaa gaacagtgag 51900
gtacttggga aaggaggttt tggaaaagtt ttcaagggga tcttaccgct gtctagtata 51960
ccgatcgcgg tgaagaagat ttctcatgat tcaagacaag gaatgagaga gtttttagct 52020
gagattgcta ccattggtag acttagacat ccagatttag ttcgtcttct tgggtactgt 52080
agacgtaaag gagaactcta cttggtgtat gactttatgc ccaaaggaag ccttgataag 52140
tttctttata atcaaccaaa tcaaattctt gattggtcac agagattcaa tatcatcaaa 52200
gacgtagcct cgggactctg ctacttgcat cagcagtggg ttcaagtgat tattcacagg 52260
gatattaagc cagcaaatat tcttcttgat gaaaacatga acgcgaagct cggtgatttt 52320
ggacttgcga agctatgtga ccacgggatt gactctcaaa cctcgaatgt tgcaggtaag 52380
tttgtgtttt tatgatcatt ataaacaatc aatcaagatc tctggactta ttgagggttt 52440
tgtgttgtta ctttggacgc aaggtacatt tggatatata tcaccggagc tgtcgagaac 52500
agggaagtca agcacaagtt ctgatgtttt tgcatttgga gtgttcatgt tggagattac 52560
ttgcggaaga agacccattg ggccaagagg atcaccaagc gagatggttt tgactgattg 52620
ggtactagac tgttgggaca gtggagacat actgcaggta gttgatgaga aactagggca 52680
caggtatctt gcggaacaag taactttggt tttgaaactg ggattgcttt gctcgcatcc 52740
agtggcagcc actagaccaa gcatgtcaag cgtgatccaa tttttagacg gtgtagccac 52800
tcttcctcat aacttgctag accttgtgaa ttctcggata atcaatgaag gatttgatac 52860
cttaggtgta acgactgagt ctatggaagc gagtagtaac gtttccttgg tcatgacgga 52920
atcgtttctc tctagtggac gctaactaat gatcatttat attgtagggt tgagattgta 52980
tgaaatggtt gtttctctgt ttccattaat taatagtaac aagtgagaat tacatagatt 53040
gactctaatt ttaaagaaag agtaaaatca aatctttgca aaataactaa tcaaaaatta 53100
aaacagctag ggttgtctcc aaatttagac gccttggtct cagaacctgg ctcgaaccgc 53160
aacatggtta tatcgcacgc atagctcata actcctgtgg tcccttttct acaatccgtt 53220
agaaacaact gcgatccgaa cttcacttct ctcttttctt tgatatcttt gataatcctt 53280
ttcctaatca aaccgtcaat atcttcttct actgaaaccc taatttgttg agctgtgcca 53340
gatttgagat cgatatacct attttatatg caagcaattt tttgtcagaa ttataaacag 53400
ttttaaataa aatactataa gattaattta taatcgaata aattatatat aacctttgtg 53460
cagatgaggt aacaagatta atagtcttgt aaaacaatga agcttgaatg tctccttgga 53520
gacatatata ggcattagga aggttactgg ggacccttat caataaatcc caatttgcac 53580
tgagacgagt ttgtgtaata ttacgcacag tgaaatccat agaagctatt tctatattcg 53640
gcgcgacagg agtttcttgg ttcgctagca aaccacaagc tagcaatatt gcccaggcca 53700
aaattagtaa acctagtaac cggagctcgc cggaggtgtc tcctgatgtt cttcgtgtgt 53760
cactcattgt gtcacgattg aaggaagatg attgagaagg tttaataatt attctcttgt 53820
ttagaaatct ggttttatat gaatatctaa ttgataataa tttttatagg cgatgaatat 53880
ctcttaataa tacacaattt gcggcgatga atatctagaa tcaaataaat atgcaaaaaa 53940
agagaggaaa aataacaaaa acgtaaaggg gaaaaagaaa ggaaacatgt aaaaagtaaa 54000
gtattggtaa ccagaagccg aaaccagaag tcgaattaga aacgaaacaa acattttgtc 54060
ttcaactatt tgtaacagag tcgcttgatt ctcaaagcat tggtaagtct ctaaatctct 54120
ctttttcttg tgtataaagt aatcaagaaa ggaagagact ttatgcctta aaattcccag 54180
agactatgtt gcatacttta ttttaaaaga acggttcaat ggcaaaatcg aattttataa 54240
ttttcagaaa tatatttatg ttgctggctc aatggtattg aatgattctc tgtgttgact 54300
ctccctaaag atgttttctt ggcaattgtc atgaatattt tggttgtgtt atcttatcaa 54360
gattatggtg ttgttgttgt ttctggtact gttcttcgtc cccgagagcg tcgtatgtca 54420
gagaccaaac ccaaacggtg tagagttcaa caccagtgga aatatgtaca ccagtggatc 54480
agcatatata aacaacaatg gtctgatcag actcacaaat tctacaccac aaacaactgg 54540
tcaagttttc tataatgacc aacttcgatt caagaactca gtgaacggta cagtttcttc 54600
cttctccacc actttcgttt tctctattga gtttcataat ggaatatatg gaggatatgg 54660
aattgccttt gttatctgtc caacgagaga tctgtctcct acttttccca ccacttacct 54720
tggacttttc aataggagca acatgggaga tccaaaaaat catatagtag ctgttgagct 54780
cgatactaaa gttgaccaac aattcgagga caaagatgct aaccatgttg gcattgatat 54840
caatacttta gtttcagata cagttgcttt agcgggttat tacatggata acggtacatt 54900
tcgaagtctc ttgcttaaca gtggacaacc tatgcaaatc tggattgagt atgacagtaa 54960
acagaaacag attaatgtca cacttcatcc tctttatgtc cctaagccaa agattccact 55020
tctttctctt gaaaaggatc tttctccata tttgcttgaa cttatgtatg ttggattcac 55080
ttcaactaca ggggacctaa ctgcatctca ctatatattg ggatggacgt tcaagatgaa 55140
tgggactact ccagatatag acccctctcg ccttcccaaa attcctcgtt ataatcagcc 55200
atggatccag agtccaaatg ggattttgac aatcagttta actgtatcag gagtcatcat 55260
actcattatc ttgagtctca gtttatggct tttcctgaag aggaagaagc tattggaagt 55320
tcttgaggac tgggaagttc agtttggtcc tcataggttt gctttcaaag atctgcatat 55380
tgctacaaag ggtttcaagg atactgaggt tcttggtaaa ggaggatttg ggaaagtcta 55440
taaaggaact ttaccagtgt ccaacgtaga gatagcggtg aagatggttt ctcatgactc 55500
aagacaagga atgagagagt ttattgctga gattgcaacc attgggcgtc tcagacatcc 55560
taacttagtt cggcttcaag gctactgcag acacaaaggt gaactctact tggtgtatga 55620
ttgtatggcc aaaggaagtc ttgataagtt cctttaccat caacagactg ggaatcttga 55680
ttggtcacag agattcaaga tcatcaaaga cgtagcttct ggactttatt atttgcacca 55740
acaatgggtg caggtcatta tccacaggga tattaaacca gccaacatcc ttcttgacgc 55800
taatatgaat gctaaacttg gtgactttgg tctcgcgaag ctctgcgatc atgggactga 55860
tcctcagacc tctcatgtgg caggtacctt taaatattct acttatttgt attggagact 55920
tatagcccca aaaaggaact tctcactcaa aatgttgtta cttggaaggt acacttgggt 55980
atatttcacc tgagctctca agaacaggaa aggcaagtac aagatcagat gtatttgcgt 56040
ttggaatagt gatgctagag attgcttgcg ggcgaaaacc catattgcca cgagcatcac 56100
aaagagagat ggtactgact gattgggtgc tagagtgttg ggagaatgaa gatatcatgc 56160
aggttcttga tcataagatt ggtcaggaat atgttgagga gcaagcggca cttgttctga 56220
aacttggctt attctgttct catccagtag cagccatcag accaaacatg tctagcgtca 56280
ttcaattatt ggacagtgtg gctcagcttc ctcataactt acttgacatt gtgcaaactc 56340
gagaagttca tcgaggtact gaaatctcag gtgaagcagc tgattctcca gagtcctgtt 56400
ccatcgctcc cttgaccttc actgaatcct ttgtctctca tggtcggtaa aagatttaaa 56460
cctataaggt ctcgcaggtt cttgatttct attgaaaatg taagtctgaa gctgattcta 56520
ataaatttgc aagtatataa gaagaatgta tattaaaaaa aacagtactt ccacgagaaa 56580
taacaggatt gatattcaag tatgttaata acatcatcct cacgtttata gtctacagac 56640
tctatacaca tacattgaca caagactgta taatacttac ttctccacaa acgtaatgac 56700
ttctctatat aacaaacatc atttgaaagt ttggagatat ttgatctttt tgctgaaaaa 56760
tgttggtgga gcccttagcc ttgtgcttca gaagatcaga taaaaacaat agtcacctgt 56820
tacatatcaa agttcgtgaa atgaagactg ctacatcata gtactttgtc tgaatagcct 56880
tttgggagag gtccttgaat ggggttttct tttggattta gactttgcct ccgagttttg 56940
acattgcttg cttctgcctg atatcagaca acaatgctca gagatcatac actaatgaaa 57000
gatatgcaac acggttttct tctcagttaa taccttcggt ttcgcctgta aatgtatcct 57060
ctctacagct cttgtgccaa gcctagaagg ctgaatttga agaagaaata ttagctatct 57120
gaggaattgt taaacttgtt atatcagagg ataaggtgaa catggtttgg cttgctcata 57180
aaacatctta cgtccttctg tttctcggct gtcccgttgc tttttgatac aacagatgaa 57240
gaacggtgag agttaggacc ttttctctcc gtgccatctg attttgcaag cctgttacaa 57300
gaaaacagat ttaggattca aacaagacac gatgagtaat agaaaactct agatggtgat 57360
gcatgtctct gttatacctg acatttttct gaccagttgt acctaacctc tgaacagcag 57420
ttgcctttgc aagaacctgg tgtcaaacat tggaagtatg aatcgatatt tagttataaa 57480
ccagtagaat ctttatcact tggtgaaaca ctattagact atacctgctt tggagctgta 57540
tcttgcccat catcagtaga tttcatttgg tcgaaactct tctgaaaact cttaaatgca 57600
cgtctaacga tgtctttatc tcccattcgt tccatgatca acgattttct tgttgttgga 57660
acagcagtag gatcggagac cgactgatcc acattgagag aaatgggcaa tgactttgga 57720
gcggtttgtt tctttctcag taaagttgag acactttcct tctttactga agagcgagaa 57780
gtagacattg aacttattgt tgaagctgac ttagacactc ttggagttga aaaccctgga 57840
ggttttaaaa caggtgatgc tgctttattt gttgcctttg tcatgctttt ttccttgctt 57900
ggttgagttt tcctaccact tacaaccttg ctcgttaccg gtttcttcgt cacctggtta 57960
gactgtaaga cgaagacaca gtcatttaaa gacattacac ataaaactat atgaggaagc 58020
ttatggtgtt ttaccttggg agaggctctc atatggttag ttcgcacatt tttatcagtc 58080
ttcttgattg gattatgatc tttctctttc ttcgtctcct tcattagtgt ttcactcatt 58140
tctccagtat cctttgatgg aacatcttct tttacttctt ccttcataca aataacctct 58200
tctactttct ctttatcctc cacttgaaca atctcttcaa gtttctcctc caacttcagg 58260
gtactcagat catccccagt atcaaccgag cttcgacatt ccttgaaatc catagtttct 58320
tcaagaggct tatggttaca tgtctcattc acttcagtaa caatgacggt cacaagctta 58380
tcttcttctg aagtactttc accgttagat ccataaccgg tactaaactc gatcatcatt 58440
gactcgtcat tgtcactatc gtctgttctt tcccggttct gaatattcgg cctgaaagat 58500
gcattcctct ccaaaagttt ctcctgctcc atgatgatat cagctctcct ctcagcaatc 58560
ttcttgtaat gtgattcgaa ataagccttc ttctgagcta ctgatccagc agttgcacac 58620
ttctccactt cttccaaata cttgtttgga gaaaaagatg aaaacttctc ccatgaaagt 58680
gaatcattct caaacttacc aaacgaaaca gacacttgca gttcttgatt cgatgaagcc 58740
gcggtcgtta tctgtttatc aatccacaaa caagtcatat aacacctaac taactatgac 58800
aaatcaagaa accacacaaa tgcaaaacag atcataggac attgacagta atgtcaataa 58860
ttaggcacaa acacatcaaa atgacgttgg agtagacaaa tgggtattac cttatcttca 58920
ccactggcaa taccaacttc catatccacc attaatgctc accagaaaga atcctaatcc 58980
acacaaaacc aaagaaaatt cttatcactt tcaaacttga acaaagccag aatcaacttg 59040
gatttgagct aaaactatac caatttttta gcatccaata gtagcttcac tgtaaagcag 59100
aataattgta gtaaagagag gaaaaacaca tataatcttg gtttagtaat taatagacac 59160
tttcaacttc agcatttttc aacctcttgg tgagcaaact cagattcttc ttaaaaaaat 59220
ataactaatt gagagtgagc ttcaataatt gaataagcaa agagagagag ccaaacactc 59280
atcaatgatt gacactaaga aaagttatca ttacaattcc aaaaagaaaa acaaaaaaga 59340
gaatctagtg gcaatcttgt aagattacct gaaaaagtga agatagccca cacaattgtg 59400
ttacttccaa aataatgatg gacacaaaaa gtagtaacaa gtgaagattc acaaatacat 59460
ttcaaagttg gaaactttgt gaggaaaaaa acacaaagag gacctatcaa gaaaacttat 59520
aaggagttgt taattttggg tcgaaaaatc ccaattacag atttgagtga gagagagagg 59580
aagaaaaaga agaagaagag atcagatcag atacaaggat gagaatgaag acaagagaca 59640
gtgggacctt tgtcggaaga tggtaagtaa gaaagtgttg tactaactaa actattaggc 59700
ggggacaaaa gcgattatta actagtttaa ctgactaatg ttgatagtta aaaatagtcg 59760
atattgataa caatcaaagt cgaaggtact ttcacattct tttactatat gaatgtcata 59820
tacaaacatt aaaccaatgc aggtacggac atccttttca caaatttcta atgtgtgatt 59880
taacattttc attatcgttt tcaaaaagca tttagaaacg aggaatacgt acatcgtatt 59940
acttaacagg tcaacccaat ccagcccact aacagcccaa atcttgccgt ttaagatgag 60000
ttattttatg tcttgaccca aaaaaaaaag aagatgagtt ctttgaactt tgaagtttga 60060
ctatggagca gacttaaata tgtgaacagt tacatactta caattgtgtg tccagtttga 60120
aaacttatgt ttccgaggag ccaagccttt aatgtctcca ttcttcttca tttatctcac 60180
actgcttcat cattgcggac agattcaaat aactcttttc tttaccatag caagtaactt 60240
ctaaccattc taagatgtaa tcttatatgt aatctacaat gacatagttt aacaaacttg 60300
gggtttattt catgctaaca acacactcgc tgcatattct tgaaaagact ctaaatacag 60360
aaaattgaga tcaacataac catttaggga aagaacacaa caaaatacaa attccaaaca 60420
aagaattctt ctaactagtc ctcatcaata gcttctacaa actcttctct cacacaagtc 60480
aatttttaca caaccaacag tcaaaaaata aatcctcaac aatgtatttg taataaccca 60540
aaactacaat aacaagtaaa aagaatgttg ttgacttaca caaactcttc agaaaaagct 60600
tgaatcttct gttaactcag acaaagaaga gaacccgaac aaagactgat ctttagctct 60660
ttcaatctta tgctcatata aatcatacgg ttcccataaa tgatccaacg gacacggtct 60720
cttctcatca agtctcaccc atggcttacc tttaccactc caatgcaaca aactcactgg 60780
tcctttatgc aaagacctac aacttcctcg tacattgtct cctcctaaac catgttggtt 60840
ccacctatga tcaattgctt caacgttccc tgcgaagaca agaagaaacg gaggcaaaga 60900
acccaaatcg tagattctct tcttcttctg tatctgcatc caagtttcaa gcttttctct 60960
gtagtttcct tctctccatc taactagatc catcaccatc acacccgtgt tgaaataaca 61020
aggctttcga cccgagaaga aaccgggtaa agccgggtcg gaccagaaac ctgaagtgaa 61080
gtactttgtg aagttagcgt gacaatactc cggagctccg atgattcttg accctgtcaa 61140
actcgtgttc caaagctttg ttatgtcatc gacgacgatg atgtccgagt ctaggtaaat 61200
gactctgtct acgcatggat caagaatatc tccgaggtag ttccgagcat agttcaatgg 61260
attctctaaa gcttgtctga ttgaagaaga gataaggttg atcaccgtat cttcccggaa 61320
aatgtagact ttgaagttta gcgacgggaa agtagatcgg acgagttgac tcagaacgcg 61380
tggactcgcc gggtcaaact ctgcagcgat gagatggaag aagacgtttt ctggacacga 61440
cgcgtggcgg agcattgaat gtacggctgc gattgagcca cgtaagtact ccgagtcaag 61500
cgtcatagct acatgaacta acgaagcgtc gcaagacgac acgaagtttt ctctgttcaa 61560
cgattgagac acgcactcct tgccgtttct gtactccgga gcttccacga acgaccccag 61620
atcaaagcca tttccgacgg tggcggatac ggcggtgagt cttcccggaa tcatccgtat 61680
accgacggaa aacagtggaa taaacaccag aaagatagca aacgctaaaa cggcagattt 61740
catcggaaaa cgcaaccgca ttttcagaaa acgcggtttc taaagtggat taaagatctg 61800
tcttttattc cgctagtgga ttagcatttt ccagaaacta tgaagcttct ggaaataaat 61860
aactcaaaga gttaaagaag tgaagaaagc aagaagatga agcagaagaa ggacaagtct 61920
ctcttttatt tggcttaaga gagaagtttg gtttacacgc gctttcacac aaagcgcgtg 61980
aatagttatg tgggttttta gtcgttttga atgatcaatc ccaacgtaat tacctattct 62040
aactgatggg attaattgaa gatttcggta attaattaaa attttattat ctgtgtgttg 62100
gtgtaccgta agagtgaaat ttaatggtgg cttttggaaa cttgtgatag gtttttgcca 62160
gctgtgaact cgatggaaac agctggatga tgttttgtct tgaaagtttg tatgggctcg 62220
ataaaaggag atcgacggct gagactaaac gatgagaagc cttttgagtt tttgattggt 62280
ttgatcaaac cctactttct cacgtgcacc acacgcttgt ttttggatca gtaaatttct 62340
taaaagtaaa tggattggta accacaaata atttagattt ctagatttta acagattgtt 62400
atctaaatat cgggaaaaag tgaatctaaa aggtattttt attttgtgtt gatcttttat 62460
caaaaaaaaa aaagagtaca ttgttatgtt taacattttt gttgttggaa taacgagtaa 62520
gaagcgtgtc tcactacgaa tattctcgtg tgtggtgcca cttaataatg ttttgttttc 62580
gttattgtcg acgttttgta gtgttgagtg tgcgactagc gccactcaat aacattatca 62640
caaatatatt catttgcact ttagacttaa atccatttcg ttagtgttgc cgcgtgcagt 62700
gtataatcgt ttgattcgaa tacgtaacga tgaaatctac ttatatgttt ttatacggag 62760
aatacatctc cttttatttg tgtatgtgat ggaaaatatt ctgtaatatt taatttaaga 62820
taacgtcgcc atgtttagtg tgactgtgtg agttaactaa tgttaggttt caactgggtc 62880
tatcggctac caaatactac taaggtcaca aaggaataaa gaaccaacct tgttatgatt 62940
acttgagttc tttgcattta ctattagcac tacaatttgt ccgccatgtt catgccaaaa 63000
tccccaacca aacaaattag aagcatgtaa acacttccat ctatgtgttt attatttctt 63060
aaaattatga acaaatatag taaaaaaaaa gatgaagata ttagtagtaa tagatcaagc 63120
aaattaaatt gaagttaggt ggtggaacaa tgatgtcgtt ttggatacgg acggagaagg 63180
tagatagaga gagtcataga gatgcttttc tctttattcg atttggtatt ataaaagtgt 63240
ttgtttgggt atgaagatat tacgatttac gaatttcaaa actatgcttt gcgtggcgag 63300
tacaacacgg gtttattgag ttttgtcttc acctctccac ttgctttaga tttttactac 63360
attccgacag ctaagtagaa gacaaacaaa gacagttgta gtaataagca gagctctttg 63420
cctttgcttc ttgtttctga tgttatccta actttgaggc aaaccaattt tatgcttcat 63480
tttgttctaa aattagactt tcacaaaaca aatatatttt catttttcat aggaccaaaa 63540
acgtcctcat ttatctgttt gttgtctgtg ggtaagaaaa caacatttgg agacaatagt 63600
tttcccttca attaaagaat cgacgttttg ataacaatcc cgaaaagttg ccaaaaatgg 63660
aatcgagaaa ctgaaacaaa aaggctttac atttgaattg agttgagaaa actaaaatga 63720
caggagcaag ttttagttgc actgtcttgg atttattgaa ccggattctc ctgcatgagt 63780
ttgcggttat aatgaatgtt agagaggaga tatgtgatgg ggaataatcg cgactatagt 63840
ttatggaaag tgttgccctc agttcctttc tatgctccaa aagactgcga attgcaaaga 63900
ggaaatgcat atctcaggag ttgagtggag gaacatatcc aagtgcatgt agtccaaagg 63960
atatgaagaa gaaatgtaag ttaactcaag ctccgaaacc tttttacgta gatatttgtg 64020
aaaagctcag atggatccgg aacagggctc tcctgaaaca aaataaataa cgcatagact 64080
aagttttggt ggtgattggt acacaattgt agttagagat gtaaaaatct cgctttcttt 64140
atcttggctt tagctacata aacctctata aattaatatt attgaaacca tgatatttta 64200
ttaatttttt ttaaaataat tttaattcat aaaattttag aaagaaatca attgagacaa 64260
ttttatcgaa atacaattag cgttttggat gttataaatt ttgtagtttc ggatttgaaa 64320
ttttaataat tagaagactt tgttttcgaa aataaattag acaataaaat tacaaacaat 64380
atacgtgaat tcattttgat aggtgaattc agataaacaa actatataca taaattcaaa 64440
aatttaatta ataatctcaa ttatcgtatt taatagctag aatattatca aaatgaaaat 64500
gatgcatatt taaaaattaa atacttacaa aaaatcttga ctgtttttat gacatagtta 64560
tagaatatat agtctttgcc aaaaaaaaaa aaaggttata gattatacta caacacttta 64620
atttaaaaac acattagacc agttatttta ttcaatacaa gtttgagatg ggttgtaagg 64680
aattttaatc ctttcactaa aagcatacct tagtatatca atatgcaaat ttatataatt 64740
attaatgaga aacacgtatt acataggaat tctaaaaaaa atcttattat cttgtcaaat 64800
tttattctaa tccaatttga gagctaaatt ttttattaat ttataatatt attaatttat 64860
ggaatattaa tttacggagt ttctattgta gtcaaacaaa taataaatct tgtatataac 64920
gttgaacttg acctgacact tacgaggaat ctttcttgtt ttcaatgata attgattaca 64980
tgtttttcgt ttgtttaatt tattataaaa tattaatgat agataaaatg acctatatgt 65040
agacatgaag atccatattt tacgggatct aaacgcctat aagttttgtc cttccacagt 65100
ccaatagaag ttcaaaaaga aaatggaggc cataacaaaa tatggatctt attttaacgt 65160
tcgtttcctt agtcgtttat gttggcggct aaacttgtcc tcttcctacc actaccctct 65220
tcttaaatca tcactgtcat tctctagatt tcaatctccc aaaaagttgt gcctagttcg 65280
agcaacgacg aatcctacag atgataactc gacgactcgt tcatttactc cacatccacc 65340
aagtctatgg ggtcatcact ttctctctgc ttccgtgaat caaacggtat ataagatttt 65400
atgagaaccc ttaattagat atactaaggg tatatatata gtatattact cattttactt 65460
gatagagatc atcaaatctt tgcaggaaat ggatgatctt tggagacaga tcgaggcact 65520
taaacctata gtgaatgcca tgctgcttcc ttgtaacggt gctgatgcaa agaagataac 65580
ttgtttcatc catacgcttg ttagtctggg agtctcttac cattttgagg aaaagattgt 65640
tgagttcctg aaggacgctt tcgagaatat cgaggacatg atcatcgatt gcaaggaaga 65700
tgatctctac acggtttcta ttatattccg ggttttcaga ttatatggtc attacataac 65760
tccaggtgag gatctttcat ctttattacg gaactaactg acttggttgg tttatgctcc 65820
gttccgttgt ttttaagtgg atgtgtgatg tgaacatttt gaacatgttt cagagttgca 65880
tataactatt tcatactact tttttttctt aatatttcat acttgcatgt gtgtagatat 65940
attcaacagg tttaaaggag acgatggaaa ttttaagaaa tgtctgaatg atgatgtaag 66000
aggtatgcta agcttctatg aagcgtcaca ctttgggaca acgacagaag atatccttga 66060
agaagcaatg agtttcacac aaaaacactt ggagttattt ttggtaggcg agaaagccaa 66120
acattatcca cacatcacca agctcataca agctgctctt tatatacctc agaatttcaa 66180
tttggaaata ttggtggcaa gggaatatat tgacttctac gaactagaga ctgatcacaa 66240
tgaaatgtta ctaaagttgg ccaaactcaa ctttaggttc ctccagctgc aatacattca 66300
agatctgaaa acactaacca cgtatgtata ttcatttata tagatgcttc atatatatgt 66360
atattttctg aaagttttat cgattaggtg tatgtatgca gatggtggaa ggagctagat 66420
ttagtatcta agataccagt ttacttcaga gagagattgg cagagcctta tttctgggcg 66480
actgggattt attacgagcc acaatattca gctgcacgaa tcatgctggc caaatccatc 66540
attttagtgg acattgtgga caacactttt gatgtatatg gtactattga tgaagttaag 66600
agcctcgttc aagccattga aaggtacgaa ctatatacga tcatttgtta ggtgctttgt 66660
aatcacactc atggtataaa cgaaaaacga aaaaagttac aaagtggaat gaatttaaag 66720
gattaaaaag tcatatttaa aggatataaa agctcaacat ctaggtctct ttatattgtt 66780
ggaatgttgg tgttctattt aattataaat cattagatgt gatccctaat aattgtatgg 66840
atccaatatt aagtaaaggt gggactccga cgccgtagat gtcctaccgg actatctcaa 66900
agtcgtcttc agaacaacgt ttgacttgtt taaagaactc gaagaatatg tgagctctga 66960
agcaagatct tttactatgc aatacgcgta tgagcaggta ctgtttcttc atctatttct 67020
taaatctaag ccaaattatt gcatctataa aaatagttac tatacaacta atgttttaaa 67080
atgtctccaa acaacaccat tctcttatat gagtaaaaca ataaggagag catttggatg 67140
ttggaaatgt tcattttcta cgtggtattt ttttcctaga tcatttagct ccacaaattc 67200
agccaaaaaa taaaatatat atctctatat taaacgaaga attgaaggtt atatatagtt 67260
cgtatttaat ataatgtttt gcagctaagg atactcatga aaggatacct gcaagaagcc 67320
gaatggtcaa atagagggca cctgccaagc catgaagaat acatagaggt cggggtagct 67380
tcgaccgcag gtgaagtgct gctagcaatg accttcatcc ctatgggaga tgctgcagga 67440
gtcggagttt atgaatggct gaggtcaaga ccaaaactga cccatgctct ttttgtgaaa 67500
tctcgtctca gagatgatat tgctacctat aaggtaacag aagtcctata tatatatata 67560
tatatatata tatatatata tatatatgta tattttaaat gcaaattata aaaataaaat 67620
gctaataaat cttatcgtat agtatttcac gtcataaact actttttagt tatttgattg 67680
ataattttga catgatcgaa atatatgatg aatttgcatc aggaggagat gaagagagga 67740
gatgtttgta atgggatcaa ctgttatacg aagcaacaca aagtaagtga ggaagaagcg 67800
tgtattgagt ttgagaaaaa gactaatcac atgtctaagg tcatgaacga agagttcttg 67860
aaggcagcca aatttatacc gcttcatatt ctaaggcctg ttttgaatta cggacgctta 67920
gcagatgtgt gctataagta tggagatggg tacaccttcg ctggagagaa gatcaaagat 67980
tatatcacct ctttgtatgt cgatctcatc actctttaag agtcttcaga gtttgggatc 68040
acgtgaatgg ccaagccaaa tttgtatccg cagccgcaac ccaaaaataa gttgtttcag 68100
tttaagttgt ctttgttttc ttggttgtta gtctgtcttg aaaaccatct tttaatcagt 68160
aataaagctt gtcattagac tatcaaaact aacaataatc cgaataacaa tctatgaata 68220
cgtagttaac acttatagta gtgggatttg gctttctctg cagatgtgca attatctatt 68280
tttttattag caccgataag aaaaaaaaaa tattaatttt ttctttgtta ttcgcttagt 68340
taataatatt aaaacgggca ttcttcgaaa tatattgtgt acgtaagtga catcaagcgg 68400
gtcaatagga acttttcgta gaaaataatc cgtttttaca tcagacaaaa aaatattcat 68460
ttatctgaga aaataataat taattgggtg taatatccaa aagccaaaaa aaaatcaaat 68520
cttgaaatgc cctgaaaaca tgaacactct tcccgtcgtc tctctcacag cttcttcttc 68580
cttcaaattc ttccattttc cttctctgca ccgttctctc tctcattccc caaacttctc 68640
cttcaccaaa tcccttatcc tcaatccaaa ccacctctcc ttcaaatcca ccttaaattc 68700
tctttcaccg tctcagtctc agctctacga ggaagaagac gacgaagaag aagaagaaga 68760
agacgaagat gatgatgacg aagctgctga cgaatacgac aatatctccg atgaaattcg 68820
gaatagcgat gacgacgacg acgatgaaga aaccgaattc tccgtggatt tgccgacgga 68880
atcagctcgg gaacgagtgg agttccggtg gcagagagtg gagaagcttc gtagtcttgt 68940
tagagatttt ggtgttgaga tgattgatat cgatgaactc atttcaatct acgattttcg 69000
aatcgacaag tttcagagat tggctattga agcttttctt agaggttctt ctgttgtggt 69060
ttctgctccg actagtagtg gcaagacttt gattgctgaa gctgctgctg tttccacggt 69120
ggctaaaggt cgccggttgt tctacactac acctcttaaa gcactctcta atcagaagtt 69180
tcgtgagttt agggagacat ttggggatga taatgttggt ctactcacag gtgactctgc 69240
tattaacaaa gatgctcaga ttgtgattat gactacagag attctccgta acatgttgta 69300
tcaaaggtat tttgcaactg cagctctctc tgtgtgtatt ttatatggtt tgctcaggag 69360
cttcttttta acctcaattt ttgtgttgaa atctttttta gtgttggaat ggcttcttca 69420
ggaactggac tttttcatgt tgatgccatt gttttggatg aggttcacta tttaagtgat 69480
atatctaggg gaactgtgtg ggaagagata gtgagttttt tttcccactg tttctcttct 69540
ttcctccaaa ggctttatct gttgagtgtt tctaagttgg tttctgtgtt tcaaatacga 69600
tcaggtcatt tattgtccaa aggaggttca acttatatgc ctatcagcta cagttgcaaa 69660
tccggatgaa ttagctggtt ggattggtga ggtgagtctg tggacatttt tcctatagga 69720
atagcttttc tttatcgtgt tcatatcata aggagttata acaatgtacg tagtgccttg 69780
ttcatcgtct catttatctt ctattgttaa gcaacttata tattgttttg ctgatgaagt 69840
atctcaattt ctagtaatct tgtactaata cacggttatt taagatgctt tcgtgttttg 69900
ttctcagata catggtaaaa ctgagttggt aacatcgaca agacgcccag ttccattaac 69960
ttggtacttt tcaacaaaac attctttatt acctctgctt gatgagaaag ggataaacgt 70020
gaataggtaa ctggttcaaa tctgtacttt tatcaccaac atttattgta aaatctttct 70080
ctttgataat aattggagga tgctttttaa ttggagcagg aagctttctc tcaattattt 70140
gcaactgtct gcctcagaag ctagattccg tgatgatgat gacgggtata ggaaaaggag 70200
gtcaaagaaa cgaggaggtg ataccagcta caacaacctt gtgaacgtaa ctgattatcc 70260
tctttcaaag aatgagataa acaagattcg tcgatcacag gtcttacatt atgctttcta 70320
acaaccctaa caaactaggc atttgtcgtt tcttatatat ttgaatatga tttttaactt 70380
ctcatgataa tttaatgact gctgagtttt gatttctagg tacctcaaat tagcgacaca 70440
ttatggcatc tccaggggaa aaatatgtta ccagcgatat ggttcatttt taaccgtaga 70500
ggatgtgatg cagctgtaca gtatgttgaa aattttcagc ttttagatga ttgcgagaag 70560
agtgaggttg agttggcctt gaagaagttt cgcgttcttt atccagatgc agtgagagag 70620
agtgcagaga aaggactgct taggggaatt gctgctcatc atgcaggttg tctacctctt 70680
tggaaatctt tcattgagga actttttcag cgaggacttg ttaaggttgt ctttgctact 70740
gagacacttg ctgctggaat aaacatgccg gctagaacgg ctgttatctc gtctctttca 70800
aaaaaggctg gtaatgaacg aatagagttg ggtcctaacg aattgtacca gatggctggg 70860
cgtgctggac gcagaggcat cgatgaaaag ggctacactg tgctggttca gactgctttt 70920
gaaggcgctg aagagtgctg caaacttgtc tttgctggag ttaaacctct cgtgtcacaa 70980
tttactgctt catatggcat ggtactgaat ctggtagctg gttcaaaagt tactcgtaaa 71040
tcaagtggaa ctgaggccgg gaaagtctta caagcaggga gaagtctgga agaagccaag 71100
aaattagttg agaagagttt tggaaactat gtgagcagca atgtgacggt tgctgcgaag 71160
caggaacttg ctgaaatcga caataagatc gagattctgt catctgaaat aagtgatgaa 71220
gcaatagata agaagagtag gaaacttctt tcagcgaggg attacaagga gatcactgta 71280
cttaaagaag agctacggga agagaaacgc aagcgtgctg aacaacgaag aagaatggaa 71340
ctcgaaaggt tcttagctct aaaaccgctc ttaaaaggga tggaagaggg gaacttacca 71400
tttatttgtt tggagttcaa ggattctgaa gggagggagc agtcagtccc tgctgtttac 71460
ttggggcata ttgattcatt tcagggttcc aaacttcaga agatgatgtc tttggatgag 71520
tcttttgcgt taaacttaat cgaggatgag ctggcggctg atgaacctgg aaagcctaat 71580
gttaaaccgt cttactatgt ggcccttggc tctgataact catggtatct ctttactgag 71640
aagtgggtta ggactgtcta cagaactggt ttccctaaca ttgctctagc gcttggagat 71700
gctttgcctc gagaaatcat gaagaatctc ctggataaag cagatatgca gtgggataaa 71760
ctagctgaat ctgaacttgg aagtttgtgg agattggaag gatctctaga gacatggtcc 71820
tggagtttaa acgtacctgt cctaagcagc ctttctgacg aagatgaggt gttacatatg 71880
tccgaagagt atgataacgc ggcgcaaaaa tacaaggaac aaaggagcaa aatttcgcgt 71940
ttgaagaaga agatgtcccg gtcagaaggg ttcagagaat ataagaaaat tctagagaat 72000
gctaacttga cggttgagaa gatgaaacgg ctcaaggcga gatcgagacg ccttataaac 72060
cgtttagagc agattgaacc gtctggttgg aaagatttca tgcgcataag caacgtgatt 72120
cacgaaagca gagcattgga cattaataca cacttgatat ttcctctggg agaaacagct 72180
gctgcaatcc gaggagaaaa cgagctttgg cttgcaatgg tgttgcggaa caaagccctg 72240
gtggatctca agcctcctca actagctggt gtatgtgcaa gtttagtttc agaaggcata 72300
aaagttcgac cttggagaga caacaactat atttacgagc catctgatac agtagtagac 72360
atggtcaatt tcttagaaga ccaaagaagc tctcttataa agcttcaaga gaagcacgag 72420
gttatgattc catgttgtct ggacgttcag ttctctggta tggttgaagc ttgggcttct 72480
ggattaagtt ggaaagaaat gatgatggaa tgtgcaatgg acgaaggcga tcttgctcgc 72540
ctgttacgac gcacaattga tctcttagct cagattccta agttgcctga tattgaccca 72600
gtcctgcaac gtagtgcagc agctgcagca gatatcatgg accgtccacc aattagtgag 72660
cttgccggtt aaagtgaacc ccacattagc tctgtcttta gtgagaccca ttggcaaaaa 72720
aaacacaaga gcctgggatg tgcaagaagt gcatatgtaa gaattgggga tacaagaaca 72780
aatttttcat tcagatgatt aatgttggaa agaataggag caacaaagaa gaaattttaa 72840
ttaatgttac aacatacaaa atgcttatat acacaatggg aaacaagact tcaaggcttg 72900
ggcagttaat ccgtttagta ttccttcgat tttccccctc cctccctttt tattttctgt 72960
gagaatacaa cagggaccag aggcagtaac agaagtaaga gccatcttac atttcttctc 73020
ttctgacaaa gctcaatgct gagtatggca accttttatc tctcaaaaag tgcgaagttg 73080
ctctattccc gagcgttttc tggtagtaag tgacagatgt cattgaccgg tgagaagttt 73140
ttgatatctt tgtgttctcc tttgcctaat taaagaacca ctgcaaacag aatcatgtgc 73200
gaggggtaaa ccgctttggt ttaaaagttt cctcctctta gcacgatgca acacatcctc 73260
ggtgtctaat acataggaga cctgaaggaa acaccagaca attcttttta aaaagacgag 73320
cttaaagtcc ttatcatgga aacgcatagt ggtgtaagca ggaaaaaagg cactgtacct 73380
ttgaagaact gcaggttatc ttacattcca aaccattaat aatcttaact tcatccgtgg 73440
tgcagagttc atcgtcacca ccatttttac gcttattcct gaaaggaaaa tagtatctga 73500
ttagtgcccc tttatcttta aaaggatggg atagccttta gttaattttc ttgactttac 73560
cgtttcaaat agattcgagg attctctttc gcattaggtt gataagaaag gaatacattg 73620
tggaggtaag ctgcaaaagt tgggtccatg gatatggatg tcacatcagg cttatcatgt 73680
ccatagtcca gaagctgaat agagagtttg cttggtgtcg attgttcctg cagaataaaa 73740
gcacaaagat acatatatta agaagtttcc ttgagcttgc ttggtccaaa actgtgctct 73800
agtaaataat tcttacacat tcaatgcggt atatatcctc atcgggaaga agcacaagag 73860
cattttcgta ataaacagca tccagaaact tctcaggctt tctggatttc tcataagcat 73920
aaagctgttg taatttgttg tccatctcat cagctgctac tgcttggagc tggaggatca 73980
cattggtcag ttggatcata tgtgacgact aaagagataa agaaggtaac aaaacatcaa 74040
aagaaaacct acatgcttga tgagcttata gatcagtttg tctaatgtga agagaacata 74100
tgactgggtc ccgataattg ctcggcaatc atcttcgaac tttgaattat cggatgtgcc 74160
atcgagcaaa ttgtagagag catccatgat tctgttccaa tacagaaact cgatgtataa 74220
gcaacaacac atatagatgc gtcctgtggt aattggtata aagaaccgca aaggaaagtc 74280
acctggcgta cgaatcagcg gggtttgttg gatttgaggt cttccacttt ctatctggag 74340
atgatgaatt gatttttgct gataatattc tgtcatacaa aatctgtata cagagtaacc 74400
acaaaaagtt agcctccaga aagattccag cgtcattgat ttgcagattc aagaatgata 74460
tgtttacctg atgaagcctg aatagaacat aaaaagaatc attcccataa aagacttgtg 74520
agttcttccg agaatcatcg ttgtccttat cgtacaaagc tggagggaca tactttgcaa 74580
gaggtttcac atgtagcagg ttttttactg agatggacaa cacaggcata tctccttcag 74640
tatcatcatg gccatcagac ataccttctt cagcctcacc ttcactttct accttattat 74700
ggtctatatc atcttcgcga taacaatctt caccatcacc agagtcagtt ccagaaacat 74760
caccgttgtg agatgtgttt ccgctaccat ctgatgatct tggagcactt gcatcatctg 74820
cagttgcatc attctcctta cttttgctga gagcctccat gtcattctct ccatgaactg 74880
cataattatc ttcttcaaaa tctcctgttg gagaaagttc accctcctct ctttcgactt 74940
tggcttcccc agcgaaccat tctgctactg tcccatttgg aattacaggg ttgtcgccaa 75000
tctgtgggat aagtaagtag tttatcactt tcgttgataa actcaggact gaagtatttt 75060
atcatctaaa gactgttcag ctcaacattt caatatatgc aataatacct ctacgcgtgg 75120
cccatttacg taatttggct tcaactcctc cgttccactg gttaatgcag gttttggatt 75180
actattgcta agccctggcg agtataaaag aaaaggatac cattcttcat ctaaaaaaca 75240
agaaaataat ccatgataac taccaaacaa gagttaaact gcttacccgc aacggataaa 75300
ctgctgattt ttccattcct ttgaggtaac aatccatcca gaggtagtgc atttgagtta 75360
tgggcacgtt caatagaaac agcttgtttg gtttcggctc tttcgtcagg tgtggtcaga 75420
ttcttcggca ttttatcatt ctgagtgttg tcacatgata acaaggcatc tgaggtctta 75480
ctagaagtaa catctttatc caactcacta gcttgccgca cttgattact ttcattgact 75540
tttcgagggc catttgaccg catagagttg gcaatactag ctccattttg aggactgaca 75600
gcatcttctt ggtcttctcg gtcatggttt gtagacttga cagcatcttc tcggtcttcg 75660
gcaccttgag ggcgagaagg aacaccaaat attggttcca aaaattctgt ccataccttc 75720
attaccttat ctaactgttc tgttgaacac atttctccac atgaatactt gatcagctga 75780
tacagatctt cgtgaagatc aggatccgga taatcaaaac tcatattgga agaaatagtt 75840
cgtctatttc cagccgcaag agcaagaagt gcatcatctt cgcctcgctt cttttcagag 75900
atctctttta tctctgccag caatgctgca gtgaaagata gtagtgcata agaacttcat 75960
aagtagattt tttctaggag cattttctct tataatatgt aaggagaaaa aaccttttgt 76020
gctcagattc tttgaatcct gctgtttgaa ataaaaactg cgatgatcaa gcgacctgtg 76080
gtagttcttt gtatatatgt cagcccagac tttgttaaac tcagtacgac accttgccca 76140
ttcttcttgc ttttgtttca aacgggttag tattaccggt aaagcaagat atgcattctt 76200
ctttaacaaa tccaacacat cgagcccatg gtcactgtat aaccgttcta tgcatcttag 76260
gtttagagct acaagacaaa aacaaaacaa tatacatcag ttggaagaaa aaaattcaga 76320
atatcagctc tgctgtaaga gaagagctca atatacctgt gaggtgatcc tcgatacaga 76380
tgggagtatc ggttttcaat tcattactgt taatctttgc caataactct tcaactcgat 76440
tagtagccga gatcacagac tctaataaca tgtctagctc gaacctaaag cacagcaaca 76500
aacaaatatt tacctaatca aaactattcc aagaaagcac tcaacaaata aacatacatt 76560
aatcactaac ctgtcatctt cacatttgaa taggctctct tcgtattggt tcttgcgcat 76620
gtgtttgaat gaatagtctt cacttcctga agtgacagag acccaatgat cattaagcac 76680
ttggctacca atctccattt tttggcttgc tataggaatt ggatactgca agagaacaaa 76740
gtatgtatgt acatttaact aatgaagcaa aaaataaaaa aaaaacaaga ggggaagatt 76800
tgttagtgat tagcaccata cattctttgg aagtctccga taactaggtg tgcactgttc 76860
acagttcgag agatctagtt cactgatagg tttagcccat ttctgactcg ctgccacctt 76920
ttcaagcctc tccttctcac ggtctctttc tctatacctt tcaatcttct cacgttctcg 76980
gtctgtatct ttgtcaagtg acttagtagg ttgaggacat ttgccttcac tccacaagga 77040
ttctgtagtt acagtaatcc aatggttaga gtcaattcaa tacgtccgaa gaggtatgtc 77100
agaagtatat tataaaaggt actagactta ctcttagaca cgataccaga gagtaatcca 77160
tctgcagaaa gaaaacagaa aaaaggtcaa atcttaagtt ctttgactgg cgagtgtaag 77220
aagagaaagc actagttgga ctggttatta ccattcttgt cacactgagc caaaaagact 77280
ttgaaggcgt ccataaggtc tggatataca ccaattaaat cactcaccta atacaagaat 77340
atatatgttc acgagtcatt gacaggtaaa gtccataagg tttctcacaa acttctccaa 77400
cttaaccatg cagtgagaaa gcttaagtca gcataaaagc ataccaaaga ctgcaattct 77460
ggttggctga ttatctcctt tgaatagaga ttaagacatc gtaagaactc ttggttatcc 77520
gcggtatcaa gctttgcctt cactctatca acaaaagcaa gttcttggct atgacctgta 77580
accacataag acaatttaag aacacaacaa ctagcagaga cgatgaactc actcctaact 77640
ttctaagaaa tcaattatga aacctttttc atcataagta gatgaactcg gaatggctcc 77700
agaaaacttg tctccttccc tggcttgatc tgacatttca gcagaatcat catccttacg 77760
tatcaatttc tttttgctgt tgaagaaatg ttctttatgg ctatcgtggt caagacctct 77820
gtaatctttc ctgtctctat catccatgaa atcattcttt ttgtcaatgc gtctcacttc 77880
ttctttacta tctttcaaca aagacctctc atggtctacg tccatatttt cggttttgag 77940
ggcacggtta ggatgcgaag taataatccg gtccttctgt aacaatatcc aaaccagtga 78000
tgtctctaag aatcaattgc atagtgaaca actatttaaa gaaaaagaga aagaaacctt 78060
atcaagatct atttgacgca tggtgggaag agacttaatg cctctatcac gtactggaac 78120
ttttacagaa tcattagtag atgcagttgc tgaagtatca gggagaaagt gagtgaactc 78180
tccaagcaaa tcgtgatggt cccgaaaaag gatagccacc tgcaagttca acatattgaa 78240
aactaagaca aaaatggaca accaaaacaa tgaaaaaaca gtgtaccaca aatggctaca 78300
aaacacacac ctcatggtag acctcagtaa tagacttgtt ttcctttcta tacatgttca 78360
aaatgtctaa aaacgatttg tatacacgat catcgccttg aaaccttgtc tgcagataaa 78420
atgatagtag ttaagaagcc aagtagcaag agaagaaaaa aaggggaaat gcaccatata 78480
taatcttcta ccttaatctt gttaacaaaa ctaatagctt cctcaaactc aacaggcttc 78540
tttggtgcag cgggttggtc atcctcgggt cggagagtta tctcgaaacc ctttggtaag 78600
aaagtattaa accccaaaat caattctctg ttccctttaa aaagttcttt cacccttaag 78660
ataacaccag tagtatcaac tctacaatga caaaataaga tcagatttca aattgaacta 78720
aagagcaaaa aataaaataa cagtgagcaa aaacaatacc tctgagcttt aaaatctttc 78780
ataacctcaa gaaactcatc gtatttgtca cgtttatctt gaaatttatc cttgacagct 78840
ttaagatatg caagtgcatc atttgtagtt agcttctgtg cactacttcc tccaaccatg 78900
gtttatattt tgccagagct tcattaacca cagaaaccaa aaaatttagc cgcaaattag 78960
atcactgtgc atctccaagc aaactcaatt caccaaacta aagtctttga atttgggcaa 79020
ttcgattgaa aataaaaata aatccttttg aatcttaaat caagaaacaa tccaaataaa 79080
atattgaact ctgcaagcaa tctcaaacta aagcagtaga tctagcaagt agagaacaat 79140
caaagcaaaa tcgagaaaag agtttaagaa acaatgaagc agaaaaaatc gatcttaaga 79200
acttaatctt cagattaatt cacattacgg cgcttcaaga taagaattaa gaaacacaaa 79260
aaaaaaaaac gcttcgaaaa aagtaaaaga tgatcgtaga gagagttacc gaattttgca 79320
gagacacaag tctacaagca caagcttcct ccttaccgca cacggaaaca caccacaaag 79380
acaagacttt aaaccaaatt ctttgcagac agaactaaaa agaaataaga cataagttaa 79440
aatcatattt atggtgaaga tgagaagatg agacttctca aaggtttttt aatttttttt 79500
acttctgcct taattgtaat ttaatttatt gtttatatta tatgatttgg tgtaataact 79560
attttactat tcattaagcc cattttttac ttaattacca gaaaaaagtt ttccctgtta 79620
ttttttacct tttccatcac catatattat ttattattat gaaacatatt aaaaaaaagt 79680
ttattaatat taaaaatgta gtaaatacgg tagaggaaac aacagtcaaa tgattaatat 79740
aaaaaaataa aaataataat aataagaata ataaataaat aaaaaacggt agagaaacat 79800
atatcgatga tggaaaataa agaattgaaa aaaatatgaa atacaactta gagacagccg 79860
ttgctaggtt gcttataggt agagtaaccg gttatagccg gtgaggttaa ttgggggatt 79920
agggcgcagc agagctagag gattggattt tggttatttt gggaccttgc aattcgggtt 79980
tgtgtagttc ggtgattttg ttatttttgg gtgatggtgt gggtataata ggaatgttag 80040
gagaatttaa ctatcaatgt catgtgctac aattagtaaa ttcgaggctt tttatgatct 80100
agaaagcatt ttgccagttt tgttttattt atttattgaa ctgttttatt tcatgtatag 80160
gctatattgg tagatcgtag atatgattat ggatcattta agtcgtttgg ttctttaagg 80220
tggttttgtg atttgtaatt tttctagttt aaagtaagtt ttcaacttct aagaatcaaa 80280
taattccaat gaaaaaatca tttctctcgt gtcggttcaa atttagtttg tcagtcggac 80340
tttgctaata ctcttttgaa ttttgatagg taggtaaact taagatgact atgtagatgt 80400
ggataatttt tggtgacata gaatatggtt atctaacaac aaagtgaagc ttcaatcaaa 80460
ttgggcattt ggtctagtgg tatgattctc gcttagggtg cgagaggtcc ggagttcaat 80520
tctccgaatg ccccctttgt tttacactat ctttttaatt aatcctacgt acacttttac 80580
ttcctttcca gttttcttat cttttgggcc caaatattgg cattttcaca cattttagtt 80640
ttagcgtttg ttattgtcgg cccattatgt acctacacga cccaacttct ctcgtttatg 80700
tttccccact ctccgagtca aattaacatt gacgccaaaa tataacaatg aactggcatg 80760
gtgatgacat ggactttggt caaacattga tgcagtttgg atggtcccca aacattgtcg 80820
ccttcatctc agagcttggc tcgaaccgca aggtggcttc gtcacactca taactcataa 80880
ctcctgtcgt tttttctcta caatccgtga gagaaaatcg cgatccgaag tgtacttctt 80940
tcctctcttt gacatcgtta ataatatttt ttccaatcaa accgccaata tctacttcgg 81000
aaacattagc tgaaatctta agaagctgag gattgaagta tttgagattg tagtatctga 81060
tcatatacaa gattcaatta gttttgaaaa tacgaacgaa ttaaggaatt taaaacgggt 81120
ttaaaaaata gtaggaaata gattcattac ttttgtgggg atgaggtagc aagagtgaca 81180
ttcttgtaaa gcaaggaagc ttcaaggtct ccttgaagac atatatactt accaggaaga 81240
tcatcaggga tccttatcga caaatcccat tttgcattaa gacgagtcat tgtaatattt 81300
tgcaccgtga aatccattga agctaactct attttcggca ccgggatttt gccagaattg 81360
tcttttatca tcaacaaaac cagaccacaa ataccaaagg ctatgagaaa agaaacgaag 81420
atccgcactc ctatagatag ttcttcgtct gccattctaa gtgattgatt gaagagaaac 81480
gaggaaacta ttttggagtg caaaaggaag atgagacagt ttaataaaga tatagttgtt 81540
aaggaaagat aatttttaag aaaatgaact ttaacctata cttaattata tgatatgtta 81600
ttaaaattta gttaaagata tagttgtttt taattaatta aagtatttca aaacaataat 81660
taagtatttt cttatttttt catttttctc tctctttttt aaaataaatt tatcctccat 81720
atcttatttc aaaacaataa tctcaaactt gctaactctc gtgattgcaa caaatatcaa 81780
ttaaatcatc agatttcacc atgtataaaa tctaaaagtt ttgaaatatt taagataaaa 81840
atataaaagt ttgtaactgt attagaaaag aaatttagac aaataaagta aaataaaaac 81900
catatattaa aagggttata gaaaaaaagt tgtaaaagtt ctttatccta caaaaaaagt 81960
ctggttttca aaattaataa ctcacaatta aagatgaaat gagtaaacgc atcagcttgg 82020
attttaaaat ctgatagctt cttccctgca ttcgacttct ctcttgttag cattgcatct 82080
gatagagctt tggcttccac agttgagcca cctcaacacc taggcaatat tcttttgttt 82140
gtatggtttg gttcaaatta tcttcttgta ccgtgtcggg tttgttgtcg tttatttgag 82200
aatttgtaat tcgccgtttg ttcttttaat tagtgcagca acctttaacc caaaaaaaaa 82260
ggtttggtac attctcacta agcataatta tattgtctta agtaaattga taaataattt 82320
gtgtattatc cataatattc agtttaaata gtataaaaca acttgaaaaa ttgagtacta 82380
gttttaccag ttcagcaaca aactaatgat aatccccatt gagtcaaatg gaagcagata 82440
aagtggcttt gaaccacaac ttgcatggct tcattgtata cataattcat cattcttcat 82500
ccataatgtg gaagaaagag atgaaattcc tcaagcaagt ctcgatggcc ttgaaaaagg 82560
atagccacct acaaaataat acattacatt aaatccaata caagaaagat ggaaaaagaa 82620
aaggtagtga aacatatata tatatacacc tcctggtaga gctcagcaac gctcttgttt 82680
tcctttttat gcgttttcaa aacctctaaa aatgagttga atacatcatt gttctgaaat 82740
cttgtctaca gaaaaaatga tatttaagag aaaagtaaaa aaaaaaattg tacagaaaag 82800
agtaatataa tttctagtag ggctgcaaaa taaacagcaa tagagaatac aaatgatata 82860
aaccgaaata tttacaccga aactaaccct taattaaaac gataaatctg atatcctaaa 82920
ttttaacact aaaatctaaa caagtttatt catctctcta aatttaaatg actaaacctg 82980
ttttttattt agattttaga tcttttggat caaaataatc ataatcaaac tctaattact 83040
agtatgattt tgcccaacta ccttgacctt gttgacaaat tcatatgctt cgtcaaagtg 83100
agcaaacttc gaatttgacg taagttcgtc atcactgagt gttatttcaa accccgttgg 83160
caagaatgtg ttgaaaccta agagaagctc tggttgccct ttgaagagtt ctttcacttt 83220
tgatatgacg tcacatgttt tagctctaca attagtaaaa aaaaaaaaaa acagtttacc 83280
aaaactttat ataactaaga gctgaaacta ttatgaggga agaagaagaa aaaaaatacc 83340
tctgacctct gaaatccttc atgatcgtaa gaaaactatc atatatttca cgattatctt 83400
gatatttagt ttttacaaga tggaggaaat caagtgcatc ggttgtagtt agcttcttat 83460
ttgcaaccat ggttttgaaa ctgacaactg gcaagtgctt cattatccag aggaagagaa 83520
aatagattaa tgttcgactc ccaatataaa caactttgaa aatcaataca agtcttaaat 83580
ctcaataaac gaattcaaga tatataagtt caaagaaaaa taatcgaaat tatcccaaaa 83640
attcatacaa ccagcgcaga tctagcaatt agagtcatag aaaacattgc aagggaattt 83700
acagctatcg accagaagat ttgaatctaa cttactcctc agattatgtc acactatatt 83760
ttgatctaag aatttcagta tagaaacaag ataggatcaa agtgaagagg atcgatcaaa 83820
gttcgctagg acacaagtat tgatggacac gttacctcac acgtaacagg cttacaggaa 83880
gatacaaaag acttgacaat tgacacaaag aaagtcgtaa ggttttaggt ttataaataa 83940
ctacatgagt catataaaga tacttaatat cacgtacgtt aaacataatc tttttgttaa 84000
cataacgatt cgattttctc tcctttatat ggatttttta ctctttttct taatatacca 84060
aatactactt ttatgagtct tatccaatat ttatagaaag aaaaaagtag gccttcagat 84120
taaaaacaaa attgataagt ccaaaccgaa gtttgtgcaa atcggttcta gtttggttat 84180
tagatacaaa ccaatcggta gatttgattt cgaaatttaa ttatcggttc ggtacgttaa 84240
acagactaac taaataaatt ttttaagttg atgtaatgat taacttatga tattgatgta 84300
gtaccatatg tttaaataga atctttttaa aaaatagtat cttactatga gagtataatt 84360
attaacgaaa ataataatac attagaacaa agtatattcc attgaagcca aaggaaaaaa 84420
aaacaaaagc gcattgtgtt gtttaagttc tttcctacga tatcaaaagg caaaagaaga 84480
agatccaaca tatgcaaact aaaacataaa aatcattatt gatgaaaatt ttacttaagt 84540
gtgaatatag tggcatatag gagcggcgtt ttcaaacgca gttgccttcc tttgagagcc 84600
aggctcaaac cgaaccgcag tttcatcaca cgtatagttc atcttcctcc cagatctaca 84660
atccggaaga agcaacctcg atccgaaccg catgtctctt ctttccttta tatcgtccat 84720
aatgtctttc acaacaacac tgtccatatc tccctcagaa gcaattaccg atgaggtatt 84780
aagcagctga ggccaatttg gtatcagatt gtaactgata gagcataaca caaaaaagtt 84840
caaacaaaaa tatatgaaca aacgaaatta gttaaagaaa aaaaaaaaaa aagagtattg 84900
aaatttttaa aaagtgtaac ctgtctaagg atgaattagc aatggtaaca cctttgtaaa 84960
gtatgaaagt ctgcaaatct cctttgagac acatatagta accaggaaga tctgaaggaa 85020
gcctgatcac taaatcccat ttaacactaa gactagtctc ggttaaatta aggactgtga 85080
aatccataga tggtattata atatccggtg catagttttc tatacgttgt tctttacgcc 85140
gtttttcacg tcgttcttgt gctgattcag agtaggcata aacgataatt gcagcggttg 85200
cgatagcgat caaaaaaacc aagacacacg tgaacacata ctttttttgt cgtggtgtaa 85260
gtctatccca taaagtggtg gatttaggag ctattatttc tccgttttca taatccattg 85320
aaacccagag agagacggat agagagatgt gtatatgcac cagatttatg tatctttttt 85380
ttgttagggt tattaaagaa aagagttggt atattgttct tataagaaga tttcgataat 85440
tacatatcaa attttttaaa aagatttcga taattacata taaattttta gattttggta 85500
aataactttc ttttcgctaa agatatttta gattaaatca aatagtaatc ttagcgttaa 85560
ttggctatga atcgtcggac agagaaaact tctcaaagga tagaaatagg ttctttatgt 85620
tgggctttag atcgttaatg ggccataaaa cgttaagact cgggactttg ggagtgctcc 85680
agcttgtttg gctacgaatc aaagaagcag gctagaacga aaaataaatc atatgatgat 85740
caaacatagt atattagttt tattatcggc caagatgctg taatttgaga tgtttcttaa 85800
caactttcta ttatcacctc gctacaattt taccattctt taccgcacca attttttttt 85860
ttaaatagcc aaaacattta tttttgttta ccaattcgtt caatagtgaa acttgagtga 85920
aatttttata aactttgttt agggagaaag tattaattgt taaaaattct aaataataca 85980
gaaaaaatgt tggatatacg aatcatacca tggataattt agtagcacct tatattataa 86040
tcttcagaat attttgtagc attagagaga tcaactaaga aaacagtgtt gaattctata 86100
attaatattt tgaaacacac attaatttgt ttaatttttt tcgtaccgcc gcatctcaaa 86160
ctaaaagtaa ccagttgtgt ataccaaagt atggtctagt catgaagatg acaattagaa 86220
gcaactaatc aacaccttaa tcttttctcg tacttgatct cgtatcccaa catatatatt 86280
aattatcttt ctttccctca cacaccacac gtacatgaat atgtatatag tgtatatact 86340
ttttaagtaa tgtatgtcga attaaactcc aagagaaaga tattcgcgtg ctttacaata 86400
agatatactt ataaattctt acttataaat tcttttaaag gacctaaaaa ctgttttttt 86460
ttttcaggtt ttggaatgcc tttactctta tgaaaagtaa tttcgaatta tccgtacaat 86520
ataaattaat aaagtaaact tatggttcta tgaaatgtta ttgagatcga cgcttattgt 86580
aatttatacg taggttctat gatatgttct tgagatccat gatttctaat gtacgcgctg 86640
cagttacata ggttttaccg atgaacaaat ttctcatatt cattgttgtt cccagatttt 86700
tattttgtat ttatggcaat aaattttttt agtaagattt gcttagattg actcaactct 86760
taacataaat aacttaaatg acacacgttt ggtttcaaaa actgtagtaa gccatatctt 86820
tggtaaaaag acgaaataac cttaatgatt aattgtaatc aaattaaaac aaaaaataaa 86880
aaataaaaca aatcttttat attttaaagc acaagtcact ccaccaataa aattttgaca 86940
aatcagcaaa accaaattat ttttcaacag aattataaaa tcaaaaagga aatcgtggat 87000
aaaaaagaaa accaaaacct atattacata attaaaacaa aaacgaaaat ccgtgagaac 87060
aaactttttt ttaaataata attttgaaca aaatttagat aaagaagaat cttcttcaca 87120
tatttcgttt ttgattttaa aaatactaaa aaaaaacaat ttaattttga tattgcatat 87180
tataaattga cttgttttag cttaccaata atattttgac atgtatcaat tcacaaataa 87240
ttgatttgat ggtaggaata gaagaagaaa aaaaacggtt atgaaaaccc ttggagaatt 87300
tattatgact aataaaattc attaaaattc aaatatgaca atattatgta aaaatctgcc 87360
gacattaata aaagtctgtc gtgacgttat gaaaatttct ttttcaaaaa aaaaaaaaat 87420
tgaatcaaac cggatttaac ctacaatcaa accggaaaat ttttacttga gggctagtta 87480
ataaatctca tgtaacaaaa aaattcgaaa ttttaaaaac aaatctgcta acaaaaagtc 87540
tattattact aaaaagttta ttctagtcat aaataaatcg gccataacat tgatatgaga 87600
aaatctgtta tgttttaaca ctgaaaaaca aaactgttat cactaaaaat aaatctgtta 87660
tcactatggg actgtctagt aattttattt tttaacaaaa atctgttata aaacaccaga 87720
tttgttaaca agttaattaa atctgtgatt acacaaaaca actctgtcat gactatataa 87780
catttttttg ggttaacaaa tctgttataa cacaacagat ttttggttac aaatagaaaa 87840
tctgctgcta ccataaggaa aaatttgcgg tatggaaaat aaatcagtga cagatttggt 87900
ttcaacattc taaattttga aattttagaa aaatctgtgg agactatata aaacaaatct 87960
gtcacgataa acaaatctgc gaaaaaataa aaatctgtcg taacttaatc cagtaaagtc 88020
tgtggtacaa aacaagtctg ttgtaaacaa tctgtggttg accaaaaaat ctgtgatcga 88080
aaacaaatct gttgcaacaa gagccacata ttcaccaaaa acgacaatgg cagttttgta 88140
aataaatgtg attttattgc catgctggaa ttaaatagta atgacgtttc tgtaatatta 88200
ttttttctgc aaaggaaaac agggacattt taggcataat tattatccat ataactcatg 88260
ttttttagta ttcctttttg gtcattatga atgaaatatg gatcactctg gtaattttcc 88320
ctaaatttta atataagact aatggaatat aacatttcaa aagaataact atatatcggt 88380
tgacgtcaaa aaacaaaaaa aaaactatac agtatatcag ttactctcat tccaaattat 88440
taggaaaaaa actgaataat taatttatct tttctatttt tataaatgtc tatgacgtta 88500
ttaatgaacc aattgtaata tgacagtttt tataaatgtc tatgaagttt taagttaagt 88560
ttccgttaca ccacggtcga attttactcg taaacattcg ctggtctcgt ttttaacagt 88620
ttgatttgcc tcttgaattg ggatttgtcg acccctacaa caagttaact ggtgtcagtg 88680
ctctgtgaag aaaaaattcg acaatttttt ttgttcgtta tatattaaca ataaaacttt 88740
tgaatcgttg attctactca atctaaagaa aacgtagaca tagatggtct ttaccaatta 88800
ccatttttgt taacgttggt ctaggtatta gctaaaagaa ttgttatgca taaaaatagc 88860
catttcgttg tatcttggac gtacctaaat agattgaacc gaattaaaac ttacacaaaa 88920
ggcagctctc tgtttacata ttcgttattt ttcctagatt tcgtttatat attaactcaa 88980
atagatatat gacatgacag aaagagaaca tagatttagt gatgctacga taccttcaaa 89040
tgtctaattt catttgctac tttatgttat atcatgtcat atatctactt gagttttttt 89100
tttatcttct tttttttttt ttgagaaaga gttttttttt atatcattac gtgtaattac 89160
actcaaatta acgttcaata gttactaata gcttatgggt acaattcaat ctaatgtgcg 89220
ggaattgttg gagaaaacat gttggaggac atctttatga aaaggagaag aagaataagt 89280
aaaggaaacc aaatttgatt aaaattttaa aaggtcaaga agatgataca tgggtccatg 89340
ttgtgctatc ttcgctcaga atcacttgcc cgcacaccac aaataatctc atcattttat 89400
gttttattta tttcccaata tagattggaa aactatgaat aaaattggta agctacaaat 89460
atataaccat ccaatatggt agcatgatgt tttcgaatct tattttctta gttgtcaccc 89520
aaatttcaaa actgttgttt tctattgcag acaagaaaaa ttatgaatat ctttctgact 89580
aatatgtata tttacttatt tcaaaataga taatattcta gataccaacg attttaaatg 89640
agggactaca agatgtcacc agtaaaaaaa ataaagccag agactaaaaa attgctttga 89700
gggagagtac atcatctttc tctgtggctg agatccattg caacaagaat gaaacttgaa 89760
aattcaaact agttttagga cttaggatac aatagtttat aactatacga aatgtaatat 89820
actttggtat aaattttcat actaacaaac ttttttttta caaaactaag ttaacattat 89880
ataatttaaa aacattattg tagagaaaat tcttttgtga tggcgcattt ttaacaccta 89940
acatattata ttgaattttg caaatcaaaa tgtatcatat acatattttc aagaatcgtt 90000
ttctaacgat cactttctac atgcatcatg catgttagac aaagtagcaa agttgtgttc 90060
acataacttt acgaaaaagt taatcatata atacattaaa atacatgtct catgtaagat 90120
gttaattgaa accatacaaa aatatataga caataagtgt gtaatgttga tttagggatt 90180
aaatattata gttgggaaca agtgaatatt gggtgagggt aatggcccat gacaagaatg 90240
aagtaagtga caactaaatc tttttcaaca aaaaaaggaa gcgaccgaat atgcctcctt 90300
caccgtccat tcactctttg ttccctccac cactcttttg tcaatccatt tgttttcttc 90360
ttatttaatt ctaatacact cagattacaa ctttgggtct gaccataaat ttttgcattt 90420
ttaagaatca atcattcgta tatggacatt tggttttcga ttacgctgct ggaaattttg 90480
tctagtgatg tattagtggg atagatttac atatattgtt cgatagcttc acagtcaacg 90540
attattttgg ctctaaaaaa agatttttaa aaaatgatgt taactaaata aaaagaaaga 90600
taatataaaa ggagatctac ggaatatagt cgtagtttgt ctccatgttc atcttatatc 90660
aaaattgtta aagatttgaa ctctttatcc gatctagagg acaatcaacg aaagcttcaa 90720
aagctgttag ttcgtgggaa cttggtttct atgttaacat gatgttccta agataatata 90780
aacataaata ttgcggtcaa acataactgt aagagtttgt aaaatttagt gaaaatgaat 90840
gatcaatttg ctaacgtatc atatttatgg cacgggatta taagtatgca acatagatta 90900
ctacccttgt gttctttttt gcaacacgta atttattttt aatcatttgc taatgaatta 90960
tgtatgccat taaaaattat caattacata cgtcataaca ctaaacaaaa tgctaatact 91020
attagtaaaa caatctcatt ctcattaatt agcaaaagag tacaattggg ggtttatata 91080
caaactgaca ttggcctaaa ccataagcct ctaaaccaaa attaagattg gtttatagaa 91140
taccaacctg tacagactct atatgaaatc tatactaacc aaactaagct tatatacaac 91200
aatctaagct atatacatta atagtccccc tcaagatgag acgaagatgt tgagtagacc 91260
catcttgctt attagacgat ggaagtgaga tggatataaa ggcttggtga acggatctgc 91320
aatttgcaat tcagtattga tatgataaag ttcaaacaaa cctttaagaa gtcgttctct 91380
gacactgtgg caatctgatt ctatgtgctt cgtgcgctca tggaagacat gattgttagc 91440
tatgtgaatc gcagcttcat tgtcacagaa gagaagagtt ggcttactca atggaacctg 91500
caattccttt aagaaatttg taagccaaac caattcatca gttgcaacag agagacttct 91560
atattcagct tctgctgatg atttggaaac aacgtcttgt ttccgtgatt tccagcaaat 91620
aagagagtca ccaagaaaca tacaataacc tgatgtagag cgacgactat cacgacagga 91680
gttataatct gcatttgcat agaccttaag ctgaagttca gaagttgcag aatagaagag 91740
accttgccca atagtacctt taatgtattg cagaatcttg taaactgctt gtaaatgagc 91800
tttacgaggt gccatggaga attgagccag cttattgaca gcaaaagtga tgtcagggcg 91860
tgtgatgtta aggtacatca atcgtccaat gagccgtcta taaggtccaa cttcaacaaa 91920
gtcaccacca ctatcatgag caaaaaccat acttggatcc ataggaatgc ttgatggctt 91980
acaaccaagc tgacctgttt catcaagaag gtccaaagca tattttcgct gacttatatg 92040
aataccctta tctgatctaa caatctccaa gccaagaaaa tatttcaatt cacccaaatc 92100
acgaagcttg aagaatgatt tcatctgtga ctttagaata tcaactgctg catcattgtt 92160
actagcaatg atgatatcat caatataaac tagaacacag agaaagatgc catcagagat 92220
tttcagaaaa caagtgtgat cacagtaaga ctgaataaaa cccagaccaa gtaaggtaga 92280
tgaaaatttg agataccact gccgagaggc ttgtttgagt ccatataagg acttcttcaa 92340
ccgacaaaca gcatttggag gtaaggagtc cccctgtctt gatgcatagc cttgaggaag 92400
tcgcatatat atttcttcat ctagatctcc attaagaaaa gcgttagata tatcaagttg 92460
tgtaagagac aatttaaaac gagcagccac accaagaaga agtttgacag agttaagctt 92520
cgcaacagga gaaaaagtct cattgtagtc aatcccttct ttttgagtat aaccttgagc 92580
aactaaacga gctttgtatc tctccacact accatcagaa ttatatttga tcttaaagat 92640
ccagcgacaa ccaatacacc ttttatctgc aggcaaagag caaacttccc aagtatgtgt 92700
accttctaag aaatcaaatt cagcacccat agcatcacgc caaacctgaa gtttctctgc 92760
ctcagtatag ttagagggtt ctttagtttt atcaagacaa gcgagaaaag taagataagg 92820
atcattaatc ctatcataag agaggaattt tcgaatttca tgtggagttg aagacactac 92880
tgaatgacag tagtaatctt gaagataagc aggctttttg gccttcctat gcgatgtttg 92940
aacagaaggt tcagggacat tattagtagg atttgcagaa ggcaaaatct ctacagacga 93000
tgatgaatca gaaggattaa catgatcaga tgattgacgt tgcataggag gtgtaggatt 93060
cagatcagga aagaaatttt gctcttcctg agaaagatct gatccaagaa agggaaagag 93120
ctcttcatgg aacacaacat gtctagaaac aattatagaa tgtgtctcta gatccaagag 93180
tttgtatcct ttaaatccag atggataacc aatgaaagca caagctttag ctctaggaga 93240
aaatttatgt ctgtctttgg gagaggtgga agcataacat agacatccaa aaactttaat 93300
atgatcataa gttggaacag tcttagttaa cacctcaaaa ggacatttgt cctctagaat 93360
aggagcagga agacgattaa tgagatacac tgcagtaaga atacagtctc cccaataaga 93420
aataggaatg tgtgattgaa agaaaaggga tctagcaaca ttgagaatat gctgatgttt 93480
tctttcaacc acagagtttt gctggggtgt ttcaggacaa gaatgatatg gcacaatgcc 93540
tttagaatga tagaattgag tgaaatttaa ttcgggagca ttgtcagacc taaccccttt 93600
aatagtggtt tcaaattgat tttctaccat agtgacaaag gtggggataa cagtaaggac 93660
atcagactta tttcttaaga gatataccca tgtagctcta gaataatcat ctacaatggt 93720
taagaaatat ctatacccat catgagtttg aacagaaaag ggaccccaag tgtctatatg 93780
gattaaatca aaaggtctgc tactcttatt attatgagaa acaaaaggga gatgtttttg 93840
ttttgatata tgacagaccc gacaatgaaa atctgtatta tttttctgtt ttggaaaaga 93900
taacaaagag gacatgggtt gtaacttttg aactgaagga tgacctagcc ttttatgcca 93960
caaatcatga ctagtaacag acgcaacagt tatagaagaa tctgtacctg gatgagataa 94020
tgaatcaaga tccacaatgt acagattagc tacttgttta cccattccaa ccattaattc 94080
ccgtgtagca tcctgaagaa cacaggaagt ttcatcaaac cagattctac accccatact 94140
cttagttaaa gaactgacac taagaagatt gaatttgaac tggggaatga aaagaacatc 94200
attaaggatg agatgtctac ccaagtgaac tgaacctata ccaacaatgc tcacacgaat 94260
tccattaggc aaggaaacag tagtatcatg aagatattta aaggaagaaa aaaaatgttt 94320
atcatggcaa atatgattgg ttgctcctgt atctatgacc caagaatgaa tagcagtgac 94380
attgctatct aaagaacaga cataaggcct agcaattccg gcaaaagaac aaaggataga 94440
gggaaaaagg ttaccggaaa ttgggcacac tgtggaagaa gaagaaggat cggaagatac 94500
tgagatagag tgtacttcag gttgaacggg agtactagga ggctgaagtt tggaactcag 94560
aaaggacaca agttgttgaa tttgagaagt cgtcaaatca ccagtcgaaa cacttgtgtt 94620
gttaacaacc tcttctgaac caatagcagc attagccgag atagaaggct tcacaaattt 94680
ctgcttagac ttgaaagaag ttggataacc atgtttcttg taacaagtgt cttcaacatg 94740
accaggtcga ctacagtaag aacaaactgg cctctccttt ttctgataag tatctccatt 94800
aagagcagac tgtgaagact gattagagac aggaaacact gatgaagtca ttcctggagt 94860
agtagaaatc cttgcagaac gttgagtttc atcttgatca atcatgttga aaacctcaga 94920
caaagatggc aaagttttct tcatgagaat ctgactccta acagtatcat aacaatcatt 94980
gagtcccata agaaaatcaa tgactctatt agtctctctt tcaatcagaa gatcttctac 95040
agtccgtgga acagcctgaa gactcgtcaa ttcttcccaa agagtttgag tacgagtatg 95100
atacgatgac aaatccagat tgccttgacg aagagagtga atctgttgac gcagcttgta 95160
aagtcgaggg aggctagatt tgtgaaatcg agtatagaga tctttccaga ttgcagcggc 95220
tgtgggaaaa tacaagatgc ttgtatagat ctcctttgat acactattca gaagccaaga 95280
cttaaccata ctgttacaac gacgccagat tttgcaataa ggatcatcat catcaggttt 95340
tggaatagat ccatccacaa atccaagctt attcttagct tcaatgctag tagtcatagc 95400
tataatccag gttccatagt tgtttccatc taacagttct ggagctagga ctaaaccagg 95460
atgatcggag ctaacaagat gataaggact atgactatta tcaggagaat ccgatacctc 95520
aaagtgacgc gatgagctat attgagctgg ttgatgaatc gcagcatgaa tcgaggatcc 95580
tggagctctc gctgatgaac cagaagactg ctcatgaatc ttcggtgaag caatgacagg 95640
aagatccggt gaactactcc gacgaacact ctttccattt cgtttaccta tggagaatcg 95700
aaacagctaa ccaaagagac tgaatcgcaa aggagacgaa aggaaaacgt gtagaagaga 95760
gaagaagaac aatgagaaga tgaacaaact ccggtgagat tccggtgaga ttccggtgag 95820
atctaatcgg agaagtttgt tacgggactg agatcgagat attttgctct gataccatat 95880
tagtaaaaca atctcattct cattaattag caaaagagta caattggggg tttatataca 95940
aactgacatt ggcctaaacc ataagcctct aaaccaaaat taagattggt ttataaaata 96000
ccaaccttta cagactctat atgaaatcta tactaaccaa actaagttta tatacaacaa 96060
tctaagttat atacattaat aaatacaaac cttcacctaa gaaaatatct ttaacccgac 96120
ataaatttgt tactacggac atgtttttgt ttaattggag aaagatatat gattgtgtat 96180
ggtgtctatt gattgattgt cacagaagta taggcatttt ctgttattgg caaactaaga 96240
aagaaaagac attttccact agttatgtaa tgcatcttcg aaatacccaa cggaccaaac 96300
ctgctcatcc tttccgtttt tgatattata taacaatatt ttatatcttt taatcgctaa 96360
aaacgaatat tatataaatg tattggatgt ccaaaaaaaa aaatgtgaat ggaggctttc 96420
atatgctata tcactatcaa ccaatcacag aacatctttg acagaaggtt acctatgcac 96480
gtacactaca catacgatgc tctttgttta tatctttgct tatagtttat cgatgctaac 96540
cactgtaaga attaagtaaa gttaatgcca atttaacatt aagttaaaat tactgtaaaa 96600
agtaaattag ataggctgcc ttttaaaaaa attgttgaat tataaccata tttgcttttc 96660
aaacatgcat gtcccaagta acagaacaaa caaaaaaaag aagaagtttg gcgtaatgct 96720
cctataccat gggttagtgc tctcaagcgg gtcatgtgta caccaacaat atcaattttt 96780
gggtgtttgc ttttaactga aaaagtaaac gcatcgaatc tttattatga tttcgatgaa 96840
taatgataaa atttgggaca atttcaattc aagtgaggaa aacgtgtctg tgccttcttg 96900
gtaaatctaa cactgaaatt tgacacgcag ttgcttctat agtcagtaat tccaataaag 96960
catctaaaat tgcatttgaa tatttaatca tagtcgtccc tatcaataat tgtcaccaac 97020
aaagataaag ggtaaataag aaacatataa tgaaaattga atggtcgtag ttttatatgt 97080
tagttggaac caaagattct tcaatctatc atccactcag agctacgtgg acagtcgata 97140
ttttgggtta tataaaaaaa aacaaaattg tactataaga caaaagaaaa cagtattaaa 97200
aaaaaaaaaa tcaataacaa gattatatct tatcccaatg aacaaaatga aaatttagtt 97260
attttgaata atgttacagg ttttaattaa attatactat atcacaaaca gcaagagtca 97320
gatacatcga acggtccagc tttcctcctt tatttttttc tggctatcgt tttgatgcaa 97380
agttgtttcg ttaatcgtga aaattaaaaa gctacagcaa tcttctccga aacttcatac 97440
actcgccgac aagagaaact tcatccactc ggatttctcg taacttgcag cactaaacat 97500
ttcatgaaac tattcacaaa agtccacgaa ccttgcaatt ggccacaaaa tttaaaatac 97560
ttatatacgt aacgacaacc tatccatatt tttctttcta acgatccaaa actggccacg 97620
cttcgactcc atggtgatat taactaggga agtggctaat ggcaaacaag tgcttagaag 97680
tggtaaattc aaataataac cgtcgattat ttctttctaa ccgttattga ggttaccaat 97740
taaaaaaagt gatcacaaac taggtcaatg aaaagggaga ttttttgttt tctttgggcc 97800
aatgaaaata gaaactaaga tggacaaaag aaaatattat aattggacaa aacagagtca 97860
tttgagattt aaaacagaga agtaataaag gtcaaatgtt tttgtggtga gctctcaaaa 97920
acagacataa aaaaaagaag cagaatcatt cccatttata acaaacctaa acctctcttt 97980
tcttcttctc tttacctttt tcattccaaa atctctctct ctctctctct ctttctctgg 98040
ctcgggaaga agatgtcacg tagttgctca cagtgtggaa acaacggcca caactctcgc 98100
acatgtccga cggacataac taccaccggt gacaacaacg acaaaggcgg cggggagaaa 98160
gccatcatgc tttttggcgt ccgcgtcacg gaagcttcat catcttgttt tagaaaaagt 98220
gttagtatga acaatctctc tcaattcgat caaactcctg atcccaaccc aaccgatgac 98280
ggtggttacg cttcagacga cgtcgttcac gcctccggta gaaaccgtga acgcaaacga 98340
ggttaataaa ataacctttc ttctctcttt cccaaatctc atctctgttt ttgtttcttg 98400
tttttgaaac tttcttgcaa atttggaatt taggaactcc atggacagag gaagaacata 98460
gattgtttct tactggattg cataaagttg gaaaaggtga ttggagagga atctctagaa 98520
actttgttaa aactcgaaca cctactcagg tagcgagtca tgctcagaaa tattttctcc 98580
ggcggactaa tcagaatcgt cgtcgtcgta gatcaagcct cttcgatatc actcccgatt 98640
cggtaacgtt tcattcttta aaatctataa ttaaaatcaa gaatctgtaa gattatacta 98700
acacataagg ttcgatatgt caacagttta taggatcatc aaaagaagag aatcagttac 98760
agactccatt ggagctaatc cgtccagttc cgattcctat tccgattcca ccgtcgcgga 98820
agatggctga tttgaatctt aacaagaaaa aaactccagc gacaacggag atgtttccgc 98880
tgtcgctgaa tttgcagagg ccgtcttcgt cgacatcgtc atcgtccaat gaacagaagg 98940
cacgtggctc acgtgcctcc tcggggttcg aggcgatgtc gagtaatgga gatagtataa 99000
tgggagtggc ttgatgaaga agataatgtt ttaattaatt tatattgtat aagataagat 99060
ctggatgatg attaatttga aatttgagaa ttaggctaat tagatacttt gatcagaatc 99120
aagtgagttt ttaagtttga attagtgtgt acatgttttt ttgctctttt tgggggaaac 99180
gacttgtcgt ttttgttgtt gtatgatgta aaacaacagg tagtctctgt gttgttttgg 99240
tcaagacttg atcagattca gaagtgaaga cgacttcaag cttaagatag tttagatgtg 99300
tcttttgaaa agtttaaaca gaatggttat tgggttaagg ttaagtgtat ctcatatgct 99360
ttttctatct ttttttttgg taagactttt ccagtaattt gccgttttct tcggggtgtg 99420
tgttgttgat aatgtcacat tcatgaacca aacacagtta tattacttta gtaacagttt 99480
ttttttgttt ttttgtttgt cgtttgacgt cattttgttt tatttatgtt attacataca 99540
tggatataat ttatgaaact gccaagaaaa caaagaatat aatttgttga attgttattg 99600
gcctaccaac tatatcagca agattcgaat ctatactttg ttaaaatgtc tcaatgtagg 99660
actggactgg agataaatat aaagtaatat atagggtaaa gtttctaagt cttgtatagc 99720
atgattttta ttagggaata gaattctaat ttcatgatgt aattcaaaca actgaaatgg 99780
aaaattgttt aaaactagct aaacttgtac agttgtacta tttagagccc aaagtgataa 99840
ctgttttatg gcttttatcc atgcaaaaga aaaacatcaa aataaagtga tgtccatcac 99900
atacatctta aataaagtaa taatgggcct agctaaggta tagcccatgg gcttattcgc 99960
tgatctaacc aaagtgtcgc taattttctt ccttgttttt ttaacgcaaa ttttcttcca 100020
tgtcaattat gtctttttaa tcaaaaattc ctccacacca aaaaagaacg taaaaactaa 100080
aaatagaaca aattcaacta cactcagata atcgaattgc tatgtccaat atccaaaaca 100140
tttcaagcca tttagtgctc tcactaaaca tattttaaca aaatatgaaa taacattccc 100200
aaaattgcga tcaaaaggct agaaacatct tcaacaatta tgacagtcct aaaccaacag 100260
ttcaaacacg ttttatatct gtttggccaa attaaacgaa tataacataa aaatacgatt 100320
gatcttagac aattactaaa gtttctaaat aataatctat actttcacaa aacaagaaat 100380
acaaattgat tcttgcgcag aaagtgcttt ggtacctact ttttttacca cctttccttt 100440
tcaattgaga catcaacaca ttcactaaaa caaactctca aactgctcta aacgacaccg 100500
tttagttaca gataacttta cttgtattta aagtcaccaa aagtttgaat ttttatttgt 100560
gccttccaca aagctttaag cttaaacaca gtcaatggcc gtccttccgc cataaaagga 100620
caaaaaaaaa gcttccctct tttcacaaaa ccctaaagaa acaaaaaaaa aaccatcatg 100680
aaaacgatct caatcttctt cgtcatcatc ttaatgtcat cttctcacgc agaagacgat 100740
gtactctgtc tcaaaggctt taaatcatca ctcaaagatc cttcaaatca actcaacaca 100800
tggtctttcc ctaattcatc atcgtcgatt tgcaaactca ccggagtttc ttgctggaac 100860
gctaaagaga atcgaattct ctctcttcag cttcaatcaa tgcaactctc tggtcaaatc 100920
cctgaatctc ttaaactatg tcggagttta caatctttag atctttcctt taatgatttc 100980
tccggtttga ttccttcaca aatatgttct tggcttcctt atcttgttac tttagatctt 101040
tccggtaaca aactctccgg ttcgataccg tctcagatcg ttgactgtaa attcttaaac 101100
agcttagctc taaaccagaa caagttaacc ggttcgattc cgtctgaatt aacccggtta 101160
aaccgtctcc aacgactttc tctagctgat aacgatctct ctggttcgat tccctccgag 101220
ctatctcatt acggagaaga tggttttcgc ggtaatggcg gactttgtgg taagccgtta 101280
tccaactgcg gttcgtttaa cggtaaaaac ttaacgatca ttgtaactgc tggcgttatt 101340
ggagctgttg gttcattgtg tgttggattt gggatgtttt ggtggttctt tattagagat 101400
aggaggaaga tgaataacta cggttatggc gccggaaaat gtaaggatga tagtgattgg 101460
attggtttgt tgagatcaca taagcttgtg caagttactc tgtttcagaa acctattgtg 101520
aagatcaaat tggttgattt gattgaagct acgaacggtt ttgattccgg gaatatcgtt 101580
gtttcgtcga gaagtggtgt ctcgtacaaa gctgatttgc ctgatgggtc tacattggag 101640
gttaagaggc ttagtagttg ttgtgagctt agtgagaaac agtttaggtc tgagattaac 101700
aagttaggtc agatcaggca tccgaatttg gttccgcttc tcgggttttg cgttgtggaa 101760
gacgagatat tgttggtgta taagcatatg gctaatggga cgttgtattc tcagctgcag 101820
caatgggata ttgattggcc aactcgggtt agagtcgctg ttggagcggc tagagggcta 101880
gcttggttgc accatggatg tcaaccgttg tatatgcatc aatatatcag ctcaaatgtg 101940
attcttcttg acgaagattt cgatgctcgt gttattgatt acggtttggg gaagttagtg 102000
agttctcaag actctaaaga tagctcgttt agtaacggca agtttggtta cgttgcgcct 102060
gagtattcga gcactatggt tgcgtctttg agtggagatg tgtatgggtt tgggattgtg 102120
cttcttgaga ttgttacagg acaaaagcct gttttgatta acaacggtga agaagggttt 102180
aaggagagtt tagtggagtg ggtgagtaag catttgagta atggtagaag caaagatgct 102240
attgatagaa ggatttttgg taaaggatat gatgatgaga taatgcaagt tttgagaatt 102300
gcgtgtagtt gcgttgtatc gaggcctaaa gaaagaccgt tgatgatcca agtttatgaa 102360
tctttgaaga atttgggaga tcaacatggt ttcttctctg agtatagcga tgagtttcca 102420
ctcatcttta acaaacaaga acacttaaaa tgaatgaaaa ggttttatta ctttcgtact 102480
ccaatttgat accacttact tatctaccgt tctcactttt aaccgcattt ttttgttttt 102540
ttctgttttg tttttgtgtg ctgtataatt ctgtacatca tgtgatgcat ccaatgaaaa 102600
tgagaagaat tgttttatat agatcaaact ttgaagattc tgattcaaaa agtctatcaa 102660
gtgttagtgt ttctatgaga ttctagttgt agttgttatc gaacgatttg aaattcgatt 102720
tcaagcgaaa agacattatc caacgatgtt tctgtttctt ctaatgattc tatggataat 102780
tataatcttt tctgatagga gaaaaaatta atgtttccca agtcgctaat gaaaaatttg 102840
ataaaatttt ataagataat aggataatat tttttgaaaa tctttgtgta aatatatagt 102900
cccttaatat ttaaattgat aatcatataa attacatata tataaattga tatattaatg 102960
tactttatgc ttttagtgtg tgtttttaat taaaattaaa ttttttgtta cagcttatct 103020
ctaattttta ttgtataaaa aaattattat gttgtgtttt taaaatattg aatcgtaata 103080
tactttataa atatgatagc attagtttga aaaacttggt ttggagtgaa acattctcta 103140
tagtttttaa attttgaata tatctcattt ttgcgtgttc taaaaaatag aatatatatc 103200
attttcattt taatagtttt atttttaaga aaaaaaatac gacaaatgaa gtcaaaagag 103260
tatgtagaac tgaattcatc taaagagttt gtattttttt ttttaattta catctatcgt 103320
ttgtataagt gaattcatct aaaagatttg taatttatta tcaaaagatg gttttcctaa 103380
atattaaaat tttacaatat atcaaaacta taaaaaaatg ataacatgca caacactaat 103440
tttgtttaga taaaaatttc ttaattcatc ttttaataaa aatttaacaa ttaattcttt 103500
taaaaattat taaataatag tagataaact aataatacta taaattaata aaatatcaca 103560
tgatctcaac atttttattt tatagaggtt ttactgtata tggaaataag aaaggtaaaa 103620
tattagtaga aaatttggaa agaatgaaac aaagtagaaa aactggaaac tagatatatg 103680
tatattaaaa ttttggcatg catgatatta cattatacat ttttataatc acattttttc 103740
aattctctgt atagtaaatt ttccgtaaat ctcagtaatt aacttttatt tctatgtatc 103800
tagttatata tacacgctct ttgtttattt tctctgtcaa cagtaaaaac aacacacaag 103860
ataagaagct aagttaagat ctttgaataa gaagaaagaa gtatgtcgaa aattttgctc 103920
ctcataggac ttgctctcct tgtaatcctt gcaattgctg ttatgggata cttaataatg 103980
aagcgtggtc aagaatagaa gccggatgtt taatttaacg gttatgtagt tttttttttt 104040
ttcttctttc tccttagagt gttggggtga aactataaaa ctttttgatt ttctatttgt 104100
gttgctccat attgttatca gtggatagaa gtaggaatga tttctagcta tttcatgtgt 104160
gtttgtgtca taatcaccta agaattatga ttttttctaa atcttatgga tgtcatctga 104220
cccccttacc ctccatgtaa atcttaatga ctaactttga aaacaaaatt ttatacaata 104280
agataatgaa ttatggaaac gaacaattag ctcccaaatc caccttatgg gctagactta 104340
caccacacaa aaaaagaaga agtggagacg tgtctgttgt tcttctttat atgtatatca 104400
ccattgactg gttttatgca gcacaaagag gtaaacaaca ccagcgtatg aaaaattatg 104460
atccggatat tataatacca tctatggatt tcacagtcct taatttaacc gagactagta 104520
gtgttaaatg ggatttagtg atcaggcttc ctttaaacct tcctggttac tatatgtgtc 104580
tctgttggaa ttgagaatcc tagattaaat cctgcaataa gtaaagcttg gttgtgaaga 104640
acagaagaag catcgtaaga agaagacgat gtcgatgtcg agaagagacg tcgtgaacaa 104700
ggtcaacgac aacaagaaga aagcaaagtc aacacaagga gatgttgggc tttgtagttt 104760
tgtaataatt atactattgg gctaaagaaa taaattaata ggcccaatga atcaaaatgt 104820
tatgaaatcg gtttaccatt caatggtaga cataggatta tgttgggatt cgataggatt 104880
aattgaaact atcggggcta attttataat tctcttaggt aaaaggttta cttgagaaat 104940
aatgagtagt atcggggctc ttatgtaaat tatcacatct cttctgcgag ttatttttgt 105000
ttctacgaag aaaaaagaag aagaagaaga aacaacaaaa atggcttctc agagttcttc 105060
actttttctg gttatcttct tcatcttcat ctacgcttct tcaattccat cctctattct 105120
cgccagagca catgaacagt ttcgtactta caattttctt ccaagttaat ttgaatctga 105180
cgatgatcga tctcgcttgt tgactcgtat ttgatttatc gatctctaca gtgacggaga 105240
tgaagagatc agaagcgttg ggcgtagatt ccttctaggt ttcaaagaaa ctccaaaagg 105300
aagtaatatc accttcgctt gttctccttc aggtccttgt gtctcttgca attcctccga 105360
aaaggttttt caaatttcct ctctaattgc tctgttttgg tatcggatct gtgatctagg 105420
gtttcagaac tagcttaatc tgattaatca gcgaaattga ttatacagtg aattggattt 105480
ggttaggaat ctgaagaaca tttatatgat ctagattgtt tttttggtga tctagggttt 105540
cataatcaat aatttatcgg cctaattgat tatacagtga attagatatg gatttaggaa 105600
tctgaagaac atttatatga tctcttctct ttgttttggt tggtgtggtt tcttttgtag 105660
agaaaagaga agtatcgttg cagtgaaact ggttatcgta ttcctttcaa atgtaaagag 105720
gttagagaag aagtggatgc acataagaaa aatggagaag aagaaacaca aaatgatcaa 105780
tcgaataaca atgacgaaga agcgaaaaca aggaatctgt tggatgattc atcaccggcg 105840
acgaaagtga agtctcagtc ttacaaaact tatagaagct gtgtgccatc tgcagacgaa 105900
gagaagttat cagttcttgg ttttgaggta cagagaaaca cttacatttc aacaagtcgt 105960
ttcttttaga atatgtgcta atgttagatt gttttgaata aatggacagt cgattatgct 106020
aggactgttt ctgttaagcg gagctgctat ttacatcaga aagagacaga cggtaccgat 106080
gcttggggta tcatcaagtg gaagattgca aggcaattct cggttttgaa agaaccattt 106140
ctcggtatgt aaaagctttc atctgctcac tcagaaacag atttaacatt tgtcattgtc 106200
tgttgaaaga tgagatatgt ttgagtgtat agaatagctt tagggggact tcatataatt 106260
gggactactt gtttcatata tggcaaccat gtttggcttt gatgatgtaa ctttgcttat 106320
cgtctctgaa ctttagagaa agcatcgatt acggtgaaac gatgtcctca cttaccttta 106380
gtagtttggt atatagtatg attgcttggt cttgaacctc ggtgatgagc ttgctggtag 106440
gaagaggtta gtacaactgt gcaatagact agttaaagta agtaacgtat cattcttgag 106500
tccaacaggt ccaacagaaa ccttacactt atcaatgtgc ctaagaaatg tggaccacgg 106560
tcaacgacaa acgaagatac tatgaaggat agtgtcgcac cgtcaaaact aatttgcagt 106620
gagtagaagt attaaaccaa atccaacaag tgacgttgca tgtaaaaacg gttgtaaaaa 106680
gttgatttag tttataaaaa acgtatcttc agcatacagt ttatcgttaa atttaaaagt 106740
aattatatgt aaattgcgag cgatgataga aatagattat ataacgtata gtaatcaaca 106800
actcttgtaa attcttcgag caaattttct cgttgggcaa tgttgaagcc tgcataaaaa 106860
tagagacccg aaggattctt atagacggga gtggtcacca cgttagcaat ggagattgtt 106920
tacaaagtta cctttttttt agtattttaa tctcgttaat gataaaatga atatgtaagt 106980
gccatttttt cagttacttc gactagaagc tagtgagtaa cacacaaagg cataagattc 107040
tcaggacaaa tatacattta acttttttag gaaaggtaat ttattttgaa gtgggattca 107100
tgtaaaatct taacaaattt gatcgatgag atgaattatg cacttatgct tcattggccc 107160
tatatttata taaactatgg gataaattat ggctgctatg tgacagtgat ataaaacatt 107220
attcctaagg aacaattttt aatcatgggt ctagtcaatc ttgtcattct catctttatt 107280
tctgaaaact ttaaaatgtg caaatcttaa gatacataaa gaatggctaa tgttattaac 107340
gcataattaa tatgttttgt taatgtacaa gattgctaat atctcgacag atcaacatat 107400
attattcgat gttttgcata ggggagctct tataatgatc tattttatta taaatggtac 107460
tagactacta aatacattaa aaaataaaac ggtgaggaat ataataagct tgatcggaac 107520
taggtagata ctatatatta tgtattgtgc caaattcgac ataaggacat gcgtatacaa 107580
ttagttatta tagatataga aatttgtgag aatacgtgac gataactgtt tatgtttata 107640
aaatatggtt ataaattagg tatgcatgga atggttatgt gcttagcttt actttttgga 107700
tacgaaagag atgaattgta cgtgagaaaa gtactagagg gaaccctttg tcacgtgtac 107760
ttctaataat ctaatatcat atgagtacat taattttagt gattaagtaa atctgcatgg 107820
aaatacacat ttgatatata taaagtgaag gctggtaaat aaattccctt catgtcacgt 107880
ttcggaccag ctgttccata tttcattgtc tctcttttct catatttttg gtccttaaca 107940
aaaaaacaaa aagagaatat tgcgtttaat gtatataatt atccctgcta tatatattta 108000
tattatttgg gatataatga ggcgacataa aaatacggat tcatgcttaa agataacact 108060
agttataaaa tctcacagaa atatataaag attcatagca gaaaataatt tctctctctc 108120
tctctctcta tcctataatg tttcgagtaa agtttgtaaa acatattgaa cagaataaaa 108180
accatcgaac atataaagaa caccaaccat cctaactcaa caaagtgata agactctctt 108240
tctttctctc tctctctcca tctccctctc tttctcttgc ttttgttgtc actcatcttt 108300
gttctctatt atagtttcca ttcaagaaaa tcgaatataa accctactac ttcgatcgat 108360
gttcatatct gtctttattt caaccaacca acgaagatag gataaaaaca tatccacaaa 108420
ggctagaaac catgcgaaat aaccattccc ttcgtctcca attgtggttc cgtacactat 108480
ttactgttgg tgtagtcact cttcttatga tcgatgcgtt tgtattacaa aacaacaagg 108540
aggacgacaa aacaaaagag attactacag ctgtgaacat gaacaactcc gatgccaagg 108600
aaatacaaca agagcttgaa gatggttcaa ggaacgacga tcttagctac gtagcaagca 108660
aaagaaaagt gcctcgtgga cctgatccta tacacaacag gttcttacta ctttctcgtt 108720
ttattttatc acttttaact aatccttacc cctacctgca tatatgtgtc ttggatgttt 108780
ctgtatgata tttcattaat atataataat atatgacata aacccgtgtg tggtgccaca 108840
ttcatattag ttaggtctaa gttcaagggc tataagccta aaattctcta caaccccata 108900
ttagattccg ttatgttcaa attatacgcg tggaccactt ggtcacttgc atttcgacca 108960
tggtgttgtt taacatgtgg tttttaccaa ggacatgctc ttagtatggt ctagatataa 109020
attcgatatt gagattaatg aatgacatct agaaatgact atattagatg aaatcaagca 109080
agctaactcg ttgattgtct atatgtttat gcatgttata ataagttttg tttcgggtca 109140
ccataaatat acttctagca caattttact aaaaaaacaa acactttgtt tcttttaact 109200
aactcagatt cggtgagaca tatcacagaa gctcgcaaaa ggctgtctgc tagctttatt 109260
cagtctttac gtttaacaat ctatttttaa ttattcacta taagatggct tcttttaaaa 109320
actttctttt ttcctttatg gaagctttag ccctttgaac actccctttt ttttcttagt 109380
tatataggta acccacttat gatcacagtt aattccatgt agatcgtatt aaagtagtct 109440
attgactaaa tcactaaaat atcaattaat gaattaatgt tgtatgattt gttatcgttt 109500
atacgaaagt aaagaaaaac aagaaaacat gacttggatt aagtaactct atgttctgtc 109560
ttaatacagg agagcaggga attcaagacg accaccagga agagcataag tacggttaaa 109620
gcttgggtaa gaagcagaaa gagagagaga agtataattg ttggcaaatt aatataggtc 109680
ttgtattgct gctagattct cttttccttt catttgggat cgaatctttt aaatatgcgc 109740
aaaatatttg tgaccctaca attctgtttt tttttttttt aaatgtttgt tttgttccta 109800
tagtgaagaa atattgagct agttagggga ggttttaaaa aaatgaagac actgattatt 109860
aaaaggattt caagaaagaa aagaagtata cgtacatgca atgcaatcct gttttctcac 109920
gcattgcacg acttatattg ggattatttc taatttgatc catcatcaaa taacgtttag 109980
atgctttatt tccttactca cattgtttat tgggtacttg cactaaatga tcattaacat 110040
ttattaagtt aggtaaataa ttgtgtactc cttttatgtg caaaaacaca aaatgggtac 110100
tattttatta ctaacatgct ttcttatcaa atagcagtac cctatgttgt tctaaataac 110160
atgctaattc aattcagatt tggcagacaa aataacatgg tattttagag agagcgcgca 110220
caagtgtgtt tttttaaaac aaatgaaaac atcataatta cgtacctgat tgacccttgt 110280
gtatatattc acgattagaa attgtagatt accaaaacac tcgcacaaaa tggttctata 110340
tatagacaat atatgattct tatcacatgt tttgaatgaa aaaaaaagaa ttaagatgga 110400
tttttttttt gtaaagaaca attgtacttt gaaagagtct tatccaatca ttaaaaaaaa 110460
tgtcgaatcc attatttatt gatgtattct gaaagcatat attcttccaa aggggcaaat 110520
aaaagagatg tcgacaaaga ttggatacat aagatattaa taatttataa atgcaatggc 110580
atatatatat gatataattt gagctctaaa tgccgaaatt tgaaaaggag aatgtgtgta 110640
atggttctta caaataaagg agaccacaat gcttctttgt gttatgcttt tttcccatct 110700
tttattcttt tgttcttttg tggggttaac tctaccacta ctcattttct cgctcttttt 110760
tcacttattt tccatatatt tctaatttct aaattaattt tactaatctt gaaatacaaa 110820
aaactattag acttagctta ctaatttact acaccaccaa catacacact acgcaacata 110880
tgctaatatg tattaaaatg aaaagaacaa aaaatgagaa ccggtattac aatttatcgt 110940
agtgtatgac tagttatgag atgagaaggt tcttgaaaaa agaattacta accaaataat 111000
gtagattaat tatttgcaaa taaagaaaag caagaatata tagcaaaatc atgagtttac 111060
ggttcggctc tataaaatct tctacaacca tccacgataa acttgataca tgaaatgtct 111120
tcttccatta aaacatgagt tccacatata aaatggttta caagtaactc tcgaacatat 111180
gtgcatggta aagcaaatat ataataccat tattttttct gtcttaatta agcaaaatta 111240
aacatatata taatatatga tccctacatg ttcactttta aagttcacaa tttcaagagt 111300
ttgaatatct ttaatttgaa ttattaccaa acgcattaga cagactaaac agagacataa 111360
taatcaatca acttcttttt gtcttttttt tttttttttt tttgggcttc cagtcttcat 111420
aatcaaaagt aactgaagac cagtcttaaa gctggaacat ttgaactaaa catatacgac 111480
tgctcctatc gctctagaaa ttttaattaa caattattca tagttactta attacaaaga 111540
caacaataaa ggtgaacgaa taaattaaag gaaaattatg aaaatagttt aatttgtatg 111600
aaacttttca tccgcatacc aaatgtcata tactcttatc ttacattttt ctcttgggac 111660
atatttttgg agcgaacact ttcgcatgta cgataaggtt cagtggtctg agcttcgact 111720
acgttaaaat gatgattagg gtttactaat ttggaattag gagttacatt taaggttaaa 111780
agtttatgag tttcaagttt caacgaagct ttaaagttta aacgatggtt aaagttttat 111840
gattatggtg ggctatgtta tagttctttc aatttcgttg ggccaaatgg gctaaacgat 111900
taacgaccct atgaatgggc ctgaaaaaat gaaagccacg tgtcagaccc ccacaatgga 111960
ctttgactcg gtgcggctgc cggagagaat aattaattat caactccgat gaaaagaaaa 112020
caaatacaaa gttccaacaa aaatcgaaat tcacaatttc tcttcttcta aatccatgga 112080
gtgatgatga tgatagatag attgaatcca aacacaaacc ggatccgaga ttaaaaacaa 112140
tccggattgt ttatatttac tttagatcgg agaaagatgc cgccggcgac cggagatatc 112200
gatcgtcaga tcgagcagct tatggagtgt aaagcgttat ctgaaacgga ggtgaagatg 112260
ttgtgtgagc acgcaaagac gattcttgtg gaagagtata atgttcaacc ggttaaatgt 112320
ccggttaccg tctgcggtga tatccacggc caattttacg atctaatcga gctttttcgt 112380
atcggtggtt cttctcctga tactaattat cttttcatgg gtgattatgt tggtgagagt 112440
ctctctttac cttatagctt tttttagggt ttctacattt ctcacatctc ttgatttgga 112500
tttgggtatt ttccctaatt tggatttgat tttgttgacc ttttggggct aatgtagact 112560
tatttggaag tgtttactag aaatggatag attattgttt atctatcgaa aagttttggt 112620
tttggaagat tttgtcattg aaaagacgaa acttttgttt tagctgttaa ctattctcag 112680
ggcttctaca atggagtagc ttgaccttgg gagatataac attttaatgt agtttgtgaa 112740
gcttcatgtt cgagtactcg gatttgtgtt tctcttttct ctgtttaagt gccttaagct 112800
ccgtttccta cttaagttgc tcaattagct aactaatgga tcattgttaa acttgtgaag 112860
atcgagggta ttattctgtg gagacagtct cacttttggt agcactgaaa gttcgttaca 112920
gagatagact tactatccta agagggaatc atgaaagccg tcaaattact caagtgtaag 112980
ttgttttctc tactaagttt tgtattataa gcttctcagc ctctctcaaa atgtttcttg 113040
ctgattgctt acctttttca ggtatgggtt ttatgatgaa tgtttgagga aatatggaaa 113100
tgctaatgta tggaagcact tcactgatct ttttgattat cttccactta cagctcttat 113160
tgagagtcag gtatttaaaa aactaatgag cgttttcact accttagaca atctcttctc 113220
tgtttctgct gttttggact tgactacaga actctttttt tctgtaggtt ttctgtttac 113280
atggaggact ttcaccttct ttagatacac ttgacaacat ccgatcttta gatcgaattc 113340
aagaggttag ttccagaatc caaaccaaca aaaggatgca ccttacttga tgtttacata 113400
acgagactaa gatgtttgtg ttgcctctag gttccacatg aaggaccaat gtgtgatctc 113460
ttatggtctg atccagatga ccgatgcggt tggggaatat ctcctcgtgg tgcaggctac 113520
actttcggac aagatatcgc tactcagttt aaccacacca atggactctc tctgatttca 113580
agagcacatc aacttgtcat ggaaggtttt aattggtgcc aagaaaagaa cgttgtgact 113640
gtatttagtg ccccaaacta ttgctaccgt tgtggcaaca tggctgcgat tctagagatc 113700
ggtgagaaca tggaccagaa tttccttcag tttgatccag ctccacgtca agtcgaaccc 113760
gaaaccactc gcaagactcc agattatttt ttgtaagtac caaaagaact aaagctgcaa 113820
ttccacacac tagctcttcg tctcttttgc ttctattctt aaccactttt tgtaatttca 113880
tattccttac gtctatttct gtttgttaaa ctctccattg tcttttaaaa tccgtaattt 113940
tttgtgtgca aagattctgg tccaagtaac tgaaaccgct atcaccaaat tctattgaag 114000
ccaactttgt acagagaaat gatgatcatg ttacacagca aaagccctag ctaggtagat 114060
ataaatatga atgttgtgga gaggtacaga caataaacaa acaagctgga gctgagatct 114120
aatctataga aaaacaacac tcagatcaaa ataagatgaa tcgagagttt caagagcttt 114180
ctagttcgct ttggatccaa tcttgtgcac acatcaaggc ttgcacggta ctcggtctaa 114240
gcgaacgcca tgtttcacta acccgtctcc tttgacaagt ttcaaaggcg tcttcttctg 114300
atgatacatt caacattgga actgctaaca cgttacgtgc catcatggag agaattgggt 114360
acttaggtgt gtgaactttc caccagttca ggatgtcgaa atctgaattc cggggaaaaa 114420
gtggctcttc tagatacttt tctagatctg atttagagtc ttgacccggt gtagtagttg 114480
tttcgttaat gtacctatcg aattc                                       114505



<210> 535
<211> 87768
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> Arabidopsis thaliana synthase

<400> 535
tataatttct gataagacca ggttagatct gcttcaaaaa gattgtattc ttagtatata 60
atgaaaagtt gaacttattg tcacctctat tcaaaagatc gagtaggatt atcacaacta 120
cacagtggtg gtgtaaactt attgaaccaa tttatcttta ttagtcagaa catggcaata 180
gaaagctaaa accagaattc tctcggataa gaggtggtgg ttctacatct ccgatctcta 240
tccgctccat cgatttcgac aaatcatcaa ccgagaaagg aatactgcca acaacaacaa 300
aaaaatacaa aatccatcat tcatgtacat agttgataaa aggaaattaa aatatggggt 360
cgaatacatg agtgagtact aacctcgaat cgtcatccag tagaaaagag ttgctaacag 420
cattgtttga atcttctgtc attagtactc tcatatttgc tatcacctat cgtataaaat 480
acaccaaaga ttggcatctt tcctgtatta tcatcatata actcaaaaca gatttttcaa 540
acttacgtct ggtgatacgc tatgagttcc atacttgtcg tcccaataca tcgtacttat 600
tcggtatagt tgttgtatgc tgagcacctg caatttcaac ttcatatttc atcaaactgt 660
ccacatttac ttactttcta aagatcaaac aattcattca cttaccggac acagctcatg 720
acttatctcg tccaaggttt ttttaggttt ttggtgtatg acctgcatat tattacaaca 780
ttaaattact gcattttgat aaaccctgac agagactgac tcttgaggtt tacaagcaaa 840
tcatgaaaat gtaccagaaa cccgatggcc tgtctgatat gcttcagctc atcccaagaa 900
gaacccgcat attcatctgt tgcattgtaa caccagtgct ccagttcagc taatcctgct 960
tttacgtatt ccccattgct aaatgaacag cactcccgtc ttaacagaag actgtaagga 1020
tgatatgaga acgcattatt aattgataca acaaggcaac ttttgagaat gagactggta 1080
atcaacagac ctattaaaca gttgaacatt gatgaatgag aagatctgcg taaacacctt 1140
ccggaccaag aatggaggaa cctaagaaaa agagtcaatg aaatgatttg aagtcttgga 1200
atctctcaaa caccgttttt tataacatga ctagattagg aactcacgtg gttcgatttc 1260
agattgttga ggaagttcgt gaggctcttt acaattcctt gccagtgggc gatcaatgct 1320
tgctgtgctg cggtgttgcc aacagaacga gatgcccctt tcactaaact cgctcttgag 1380
gttcttggtg cctattttat atgaccaaca aaagaagatt taaatccagt gaagaaatgc 1440
gcaattgctt gaacatgtaa ctgatgtatt gccatatata cctgaatgca caatccaagg 1500
agtggagaaa tctctttctt caaattatca cgaatcattc cgtatatttt ctcaacatag 1560
gctgttagct gttgcttgaa gaggagagct gggtatttcg cctcaacttg ccttaaggta 1620
tcaactccac catttatcat ggcaagattc acaccttggg gtgtgccgcg aaagctctag 1680
agaaagattg acattgacaa gttaaaactt gtgatgcatc tgatatgatg aagtttatat 1740
attagttggc cacacacaca cctgagtcat cctcccaaag agagtggcag aagatgagcg 1800
acggcgctgt ggagccattc ctgctgctcc actagcttta agcgtgcgtt ggaggagtaa 1860
aagcaatgtc gaggcattgg ataaccaata tgctagtata ttgttgttgt cttgcgtctg 1920
aatgagaaaa aaaatgcaat cactaccagt ccgaaatcca taactttcat tttcgtatct 1980
caaaatagta tagtagcaca aacaaacctc aatagcttgt cctattgtct gaatgatcct 2040
atcaaagaca ctagttcttt caacttcaaa tgaccgccat tgcaataagc atttgtatat 2100
gatacatgct gtaacaggtc gtttcccttg gaaacccaaa tgttgaacga tgcagcgaat 2160
aagcagctct tggttttctt gctgcttctc gtttagtgat ttctgtggct tatcgtccac 2220
ttcagagaga tcccttcggt taattgaatg gctatgcaaa tcctgattca aattaaatga 2280
aacccaaata gaagaatagc acgattaaga gaactccaca aaacatgcaa gacaatattt 2340
gttagacata tcgaggtact taccaaactt ggccttgcat caactgatag atgaccactt 2400
tctgaacctc tctgttttgt ttttatgcac atatggaagt cattaacttc agatagaaaa 2460
acaaaacaaa tggaggccaa cagttttctt ggtatattat ccgtacctgt aaaatcgacc 2520
tggaccggcc agagagaaac ttatttggtg caatggacac agcttgttgt cgtaacacct 2580
tattctctga ttctaaattg ttgcattttt cttccagcct gaccatcatg attacaaatt 2640
tcagcgcaac agtgtcacga atttccatta atacatgtga ccaagatcta taccattatt 2700
tacttcctac tattaagaaa ttaatgattt gatattgact taccttgtca cggactcttg 2760
gagctgctga gcttttttct ctgtgtcttc caactttttc tttctgtcct cgctagactc 2820
ttgagcttca tcaaatttcc ttgttgcatc atcggccctt tgtttctctt gttcaagatt 2880
agcctgttgt tacacaaatg attactaatg ctccatacat tattctgcaa caatacacta 2940
agagtcgaat tcaggcattt taataaccaa caaaaaacct agcgaaagga taaaccaatc 3000
tgatcgccaa tgaatacgag atttaagttt ggacaaggag ggagtacctt tagaccctcc 3060
acttcttctg tcaatgcttc aatcttctgg gtatcttcaa ctaaaacttg cgtttctgtt 3120
acaacaggag gcgcttcttc aatggccttc ttagcagctt cacgttcctt aacaagaagc 3180
ccatttgttt catccacttt cttccgcatt tcctctaatg aactctgcag tttttttatc 3240
tcctgattct tttcttcttc caggtcaacc tgacaaggtt tattatatgt ttgcttcaat 3300
atcatcctac cgaaaacaaa tatatttatc aatcaaaatc atttttctgt atcaaatacc 3360
cttgagcgtt tctccaactg tgcacggtat gtgagttctt cgactttctt ttcgagcata 3420
tcctttgcct ctttcagtgc gcctgtttcc cttgaagcct gaagataaca aaaagtgttg 3480
atgagtatgc ttaggataat agtttaccag aagatcacat acatggcaac cagcttatca 3540
ataggcaaaa catgaaagaa aaataaagaa ctctctattt catcttcaaa agtccctaaa 3600
agtggcaatt acacagtgaa cgtacaaagt gcacccacgt accattttga gctgtcgaag 3660
ttctctcctt gcaagtttgc ctctccatcg tgtctgagac aggatcactc ctttcttaag 3720
cttcttgaag tacaaagttg ctctgtgaca acggaactga gcctgcaatt tataatatgt 3780
taatgcgtta gtaagaaaac tcccaaaatt agataagctg accaatgtat attcccacag 3840
atatataaac ctgaatagtt gtagcagcct ttgtttgctt cctgaatcta aactgtttat 3900
gagcagccat tgctcttaaa cctgtttgta caacaagcgc cgctacatgg aggtttttgt 3960
atgattttct agaatgtaat ctccgagcat tcttctgaat cttcacagca gcagcttgtc 4020
gtctcaagtt atcgaaaatt ttggaagaaa gtcttcctat aattttcgca aagaatagaa 4080
acttattaat catcttatat ctagaaatca ttcaatcaaa ctatgagaaa aacatttttg 4140
cttctaaatt ctaaccaaga gaaagtacac aagagaggga ttaagagact ataagatgaa 4200
tcagatggtt cacctctgca taaggcttgg agagatatgg tggcttttct tagtaaaatg 4260
aaccgtcttt gggcctgatg agtccgtatt cgtctctgaa tttttttggc agcagcactg 4320
agaaccatag ttcttctcgc gtcgagttca gccatctgac ccgcccttaa aaacaccttt 4380
gttttaccaa cctgcattac ccaacgatca ttgaaccata ttccatggca tcattagtat 4440
tagataatgg ttgaacgaag aaaaagacac ttaaaatcaa aacctggtat cctttgagtc 4500
caatattgtc taagatcttt tgcgctgcag ccttctcctc gtagctgttc aggaacaagc 4560
agtatacaca ctgtttagtt ccaagatatt tgttataatt ggatcaacag aacgaaagga 4620
ttcacttact tcccttctag agctcgagga tatagaagtc caaaacggtt aatgaactca 4680
aagaaaggtt tacgagtggg ataccccgca caactgattc tgatcgcttc caaaacaccc 4740
tacacaaata caaaccaaca atgtctgttt gataaatgaa aatttgtaat actcaataag 4800
tctagaacaa caccacagtt ggaatcattt ttcatctatt acttacacca caccgaagtt 4860
gctgcataat gtttacattc tcaaatacgg caggcttcaa aaggttattg ggcttcacac 4920
atctgatgta gtgaggctcg gtagagttta atgtttccat cagttgctgg agttgcaact 4980
gcatcaatcg agaaagcaca cttaataccc gacattggaa tactttcaga gaattaagcc 5040
tatctacctt aaagcgagag ccaatggaag aaaactttga agatttagat gtttcttccg 5100
ggagcggagg aaagagaccc acaacaaaag gacacttgga agcacccaac aaatcttgat 5160
gttcagggat aacataatcc ttgtttttgt ctagaaatag atcagactga tactggacct 5220
gaaatgatat tccacaaaac aaaagtacta ataagaaacc tataagacag ttgattgtgt 5280
tgtacaatgt taagtttcct ttgaaggaaa aaagacccta cttctccagc ataatgggca 5340
acagcaaaat ctgttcgaga gagttttggc ttgatgaacc tcttgtgtgt cttaaaagtt 5400
tgataaagct tgttcgcaaa tgtttcatgg gtcgacttcg gaaacatgct gaagaaccaa 5460
gaaacattgt tcaaaataag ataaaatgaa cataactcaa gttacataca caactcaagt 5520
tgattgatgt taatattacc aagcttcatc aaggagagcc acaattccac caggcttctg 5580
cagatggaaa tttttctttt tgagtgagaa agatgaaata tttagattgc attgtcattt 5640
cggagtccca atttaaagac cagacaaaaa tgtgatattg atcagaaata accttttcga 5700
taagatcgag aacatcttgg ttatccacaa attcaatgta gctccaatct attgcttctt 5760
ttgtgtattc ctcctgttcc atcttgaaaa cgtgctgaaa acagcaatag aaacttgtaa 5820
accccaaaag cctaatctgt gaaactcagg ggaaatggtt tacactacaa tcaagaaatt 5880
acctgattga aatgttgctg caacttctca tttgtgaaat taatacagaa ctgttcaaaa 5940
ctgcaggaga tcgctattag cagtggaaac acaaaaatct aacggaagtt tagttctgaa 6000
ccttggcgca gtagacattc cttacctatt tgttttaaag ctctcaaatc cgtatatatc 6060
caggactcca atgagtgatc tagaagtcgc atcttggcca attgagacgt tgatcttttc 6120
taccaacctg caaataacta gagatgttaa cttagaatca aatctgtcaa tcaccaatac 6180
ttgtgtagtg ttactagtga caaaatacct attaaaccag ccacttacca atcaaataac 6240
cgagaataga tagtcttagc tagaccatct ctgctgatta aagcactctg aggatctaga 6300
cttctcttga taacttcctc aggtgtgacc ataacacgtt tacacagtgc atcttcaagc 6360
gcctttacat cgcacctaaa atgagaggtc tagttagtgc atgtattgag aacaacaacc 6420
aagtcttctc gggacaaaaa tatttactta catgagaagt tctgccactg tgttaagatg 6480
aaatttcgac ttgtcatctt tgggaactga tgaatccact tcttttccct tggtaaattc 6540
gacgttgcca aggtggagaa ttgcagcaac cactctgaaa attgcttcct gttgatttat 6600
atagagggtg acggatcaaa ataaatacca aaatgcatca gaagatcact ttcatacaca 6660
agcttacctg ttccttttcg ctcatcccga caatatccat tgctcttctt gtcgcaatgt 6720
aatcatgagc atcacttata ccaacaagtt cgaagcattt cgactggttc agataatgaa 6780
acgtcttggg atgacccaac ttgtactttt cgagctcctg ctagttctat aatgttatgc 6840
caagagtttt caatgacaat cagaattaac aaagacttcc tggtgagtat acctcctgtg 6900
gtgcagcaca tagaagataa aaacagtggt aattgcgctc tggatcagaa atctgacaga 6960
cacgagacct ctctagtaga tacgtcctta ctgcagctcc agatattctt ccttgcttat 7020
caaattggat ttcaacaaat ttaccaaatc gactgtgaga aaacaaatta actatcagct 7080
caaattctaa caaaattttg taagaccaca caatgaatta tgcataggtt ttttcacctg 7140
gaattgttat tcctgacagt tttggcgtta ccaaaggcct caaggacagg atttgactgc 7200
aagcagaagt tacaggcgta ttatcacggt gtgtgaaaga ttatgtaatc aagattgcag 7260
aaacgtaaaa ggagaatcta aaagacaatc cagattgatt agaacatcat acttcaagaa 7320
cttgttgttc aactgtccgg ccttctgtaa cagcacgacc tccaagatat gcaaggtatc 7380
tcataagcat cttcgtggtc tcagttttac ctgctccact ctcaccactt acaagaatag 7440
aattgctttt gccctcattg atcattgccc tgaacgtaaa tatcgcatct cagcttacaa 7500
cacaaaccac aagtatataa taaggttaaa agctgacaaa taagagcacc tgtacgcaac 7560
atcagcaact gcaaaaacat gaggacttaa ttctccaaat ggtgctccct tgtactgttg 7620
catcatatgg gcatcataaa tatgcggcag tcgttgaaat ggattaatag cgataaggat 7680
atttccagtg tacgtctgtc aagacaatgc aagaaactgt caagaaaggc agagtcttaa 7740
gatccaaaaa gtaaagaaaa aatttaggta ctaacataaa tttcattaag ttcatatctg 7800
atctttaagt tctgaagaac accaggctca tgcaaataag atagctttgt catgtcatca 7860
actccacctg caggtgcttc catatctttt gggtatatct ttgacaactt tgcagtgatc 7920
tacacagaaa caaaaaatta gcaaatcagc ttcagtgtat tccaggcttc aattatatgg 7980
aaactcaaat atgtttttaa ctcgcctttt ttccgtttgt ggcttgaacc tcaacatctt 8040
gtccattgat cttttcaacc agaccatcaa tccaagccac atcagaatct tcaatccaaa 8100
catgagagcc tacaatgatg ttaaccggag ttccctgcaa ttttatgaac aaagaactag 8160
cgttttgata ggcgatctac gacatttagt aattagatac tcaatgtgaa taccgagtaa 8220
tatactaatc taagaacaga gtcactgaat ttctcatctc attgttcttc cactcttaga 8280
tttcaagcct acatgctact aatcgagaaa ttgaaaaatc tccggttcga atctcaatgt 8340
tgcataaaca atattttaaa taaatgaatg aatgacatac catttggaag cttcaaatgc 8400
aatgctcagc tgaatgaaac cctatccatg ggtagatttc acagaaactg acttgttaca 8460
caaggaagct ataagattat gtaaattcct aaataaacac atcgagaaac cccaaaatca 8520
caattcaaca ccactcaaat tacccaaaaa cgaaacgaaa caactgcata agtccacaga 8580
gcctcgagaa ttagggtaaa gcagaacaaa attaaacgaa atcgagtcac caaaaaactg 8640
agattcgatc gaaagaggtg tagaaaacgg aaaaaacggg aagagagaat agtgaatgaa 8700
aaattcagag agtggcataa tgttcttctt cttcgccgag ttcggtgttt cttccctacg 8760
aattcgcgcc aattcgtggc cctaaatcga gtctcttctt tcgcacacat caccacactc 8820
tctctcatcc ttctctttct cagctttttt aattttggta acaaatcaca ctctcaattt 8880
tttcaaagct aaaattgatt ttagactttg gttagctcac gaattaaatt ttttctaatt 8940
atttactttg aaattatcac gtaatatgaa atacattcga gcaagaatca agcaaatgta 9000
aatttatgaa gttctttcac tcgagtaaat aatgttttca tctatataag aaatggaata 9060
tacataaaaa attctatacg agacattatg acacaacaat ttttttgttt tcttttgtgt 9120
atgtaacaag actaaactta cccttttttt tttgttcgaa tcatggctcg aaagatggaa 9180
catgagttgc ggtagtgtgc gtcaaactgt agtttaatct gtctaagaca cttctgtatg 9240
gatcttcctc tcgtttcttc aacaggtagg ctatactatt ctctacctcc gcctttacct 9300
ccaagtaaac ttgatttgct tcttctttgt cttttacaag ctctggtctt ccctttgtct 9360
ctatcggttt cccaaacagg taatagaacc tacccgggac tttcggtatg agtcctggta 9420
ggtagagtgg ctggtttgcc acctctccct ctgactcttc cctatcatca caaacaatag 9480
tactcatcaa tctttgacta gtaacaacta cactcattag catctatttc agttatatga 9540
aaaacaatgt tacctcaatt taaattgttt ggtatcgcga gtaacttccg tgatatagtc 9600
attaagaata gggatcttca tcaggtcgtt gtaatcaaga accaactgca atagcaaaag 9660
aaaaatatat ttataaatga ctattttcaa taactgagca cacgaaattc aaattttttg 9720
ggaagttttt ctgtgacagg aagcttactt cagctatgtc gtcttcacca actgttccaa 9780
acggcactat tgttgcacca aaccgtgctg ccattcttac aaactcttgc tgttcaggcc 9840
aaattagttt gtattgttca ccctgcaatg tcatagaaag tagtatatgt atcatcagaa 9900
attctaacaa caccaccagg ttaataaatt aagtacacac ttctattagg acaaagaaac 9960
agaagatctc agataaccaa atcattttag tattatttga gcttaaacag gttcaactgc 10020
atagtcaaga ctttgatttc accgtcaagt gggtggaacc actctccttt tggctactaa 10080
tttttcttaa accaaactag aaaaaaaaag aattgaaaga tggctaaccc ggttatggag 10140
agcctctcgt gcaccaccag ggaagagaag gacatgagat ttagaatcta acagcttaaa 10200
tagattggtt gcggtgacag gataggcacc aaatacttta atccagtcac cataatcaaa 10260
cgccttagct ggatcattat cagaatacag aaccggatgg gccattccac gaaagagaat 10320
gttcttctct tttataaacg cctcggacat tggaccaagt tcaagaccca tcaacatgtg 10380
gtaaccaaca agtagcaccg gacctttatc tggaacacca gcaagtccct tcactatttt 10440
cccgtcttcc atagttgaaa aaaacacaga accaacagca tttcgcaaga atctgcatat 10500
cacaaggaat aaaatcagac cagataaatc acatgaagct aagtacattt ggttctcttt 10560
tgctcatttg aggagatcaa ggaacgagac acattaactt gtagtgtcaa ctgttttgga 10620
gaaagttttt gaatatttag tagatggaac ttttttctaa gagaaataga gtcaaggaag 10680
gcttagcaaa gttacccaag cacttcatca agggcgtaag caagttctcc cttacttgga 10740
ggcaagaaat cagaaaccaa atcatatctc caggaccgcc ggtacttgcc tgtacctttt 10800
ataactgtga gcaaactgat gctatcttcc tgggacaata aatggtagta tgtcaatgaa 10860
taaatagtca tactactctg tgtttttctc ttcttgtaag aaattactct aatactactt 10920
aatagcttca cctaccatcc ggaacaaaag gaaactcaag agtaatttag tatgtaaatt 10980
actatgttaa attaccaata aaagggtatg cccattgtcc ttgaagcatc gaactgaaca 11040
gtttttaagt aacccgtgaa gccgctttgc ttcttcttgg ctaggaagca tcatgtcctt 11100
tccactgaaa gtcgatgaaa tccgaagtca tttctatttt cttgataata tgtcgctcat 11160
tgtaagccag gttgtggtat ttctttcata gaccacaaat aaagaagaga gaagaaatgt 11220
tataccataa gaaagaagat tacctagcaa ggaccaagac ttcagcttga acagcatgga 11280
tgcgggaatt ggcataagca cagccagatc tcagtaactt aagcttccaa agtaaggttt 11340
cccgtggaat aattccaccg agctcctgaa aatgaatggt tagaaaagat gttatctttt 11400
atagaaacag aacaaagtaa atgcatttaa agaacactca cagagagaag cgggagcatt 11460
gttttagtaa gcctttgtct caacttttca atttttactc ctgttggaag ttggttgtcg 11520
ataccaagtg tcgccatctt tatcggatca cctataaatc caagaaagct taagtaaaga 11580
caatttaaga agacaaaagg ggacttaatt aacttataca ataaacatca gttcatgtac 11640
ccataataaa gcttagagca tatggaacag taaaatgaag ctcctctggc accatctcta 11700
atataggcag caacggctgt agcggtgacc tatcaaatga tgtagctaaa aaaggagaaa 11760
acgtgtttgg tcattcataa aagcttatat gcaagtatgc gtttagatac aaagctacaa 11820
aattaaataa atgtttgctg acctgggttg actagtatca acaccaagtc taacgaacgg 11880
tttctagcag caacagcaag agccaggcat cctccaaagg aatcgcccac gagatatatc 11940
ggcttattag gacgtgtagc ctgctcctgc ctcaaaacat cttcgactac tttcagaagc 12000
cctttatggt aaaaccaaca gaagagaaca ttcagagaaa atcaagtaaa caactaatga 12060
ccttatacag aatcactagt tagatatttc tatccatttg gaagtcaata ttcatttgta 12120
aaaatcttct atttgatgtc aaagacaatg aactgagtgc aagtaatcta agtattgttg 12180
tatgtacata tatacttgta gaaatgtatt tatacacagc acatgcatct aaaagagaaa 12240
acacaagcca gcgaagaact attctatgat cttaaaggga cagctactgt ataaaatctt 12300
cataaccaaa tgtatatatc gctatctttt tattaccttc aaatggagtt cgatcaagta 12360
caggaatatg caggcacgag acatgaaaag ccctgtattg aggaaataca agaacaacag 12420
tttagactgc aaacacttgt gtgattaaaa acgagattca acataatatg aagtgtcagt 12480
ttgtttggat tagttttctt gcttctgcat taagtattca agtttatata tttacatttc 12540
cacattctta gaccaatgtc atttccagag aaactagact taacaaaaat agtgaacata 12600
cttgccaaga gctttgtgat gtggaacaag gcccatccct gtgccatcca tccctgcata 12660
aaatattaat ccatcaggca ttacgaaagt ccaaaaattg gaactttgaa gcgataatca 12720
gagagtcaga tacttgacac tgaaaaacag taaaaaaaac cattactaga attcaaaata 12780
cagcctaaac aataaagcat tatcctaaaa gcttggaact ttgaaacgaa gatttagaat 12840
cagatacatg agataagaaa acagtaattc aacaaaacag cctacagatt caacctttcc 12900
tccatgaaac acacaaagaa gtgagaaaat gaatacaaag tttcaaactt tggaagaata 12960
gtaaattttt agctcatgaa gcacacacaa acctcacata ggtcaagcaa tttcaacaat 13020
caaagctcaa aaaccattga ttcttataaa tcactgattt tgttttacca ggtaagaaga 13080
gtaacgtagg agcatcttca acaggtcgac cacaatcaac gggactaaac caccgtggag 13140
gaccaccatc agccttcaaa atctctttag ccgcagcaaa gtaatcttta acagatttgg 13200
agccataccc atcatcccat aacaactcaa tttcatcact cactatcttt ctcttggatt 13260
tccctttccc attcacttca tttgcccctt tttggttttg aacagtagta gacaaagaga 13320
ccgaaccgtt gttgttcact ggttccaatg atgtcgcctt cttgttttca ccagagattt 13380
gagctcttac cttgaaattg cgtctttggt tagaactcaa tctcaaattt ggtaacacca 13440
ataagcttga agaacatgtt gccattgtct tttgattcag gcagtccaca ggcaacggga 13500
ggagagattt cttagaaacg attaccaaaa aataaaaaat aattttaaaa agattgaaac 13560
tttaaaaata tcttacaaaa gtttttgaac agacaaagca atttttttta aaaaagaaag 13620
attattaata tttcttcttt ctttcggttt cgttttagaa atgtatttca tagaaagtgc 13680
taaaaataat aaaataaatc tttagtagaa aagaattttt aaatttccat cggacttcaa 13740
tttcaaacct ccatattaag gaagtggggt ttacaagagg tagacaatca gacacctaaa 13800
ctacttgaaa cggaaaaata aagaactttg tattctttct tgtgtggtgc acagaaaaaa 13860
aaaagtatta tgatgtcttt atagcaagaa atctgtactg caatacaaaa tgggaaaaga 13920
caaagcattt gtaataggta agttttaaaa ttgtaatata tggaatagag aatgttttta 13980
gtcaattgct aaatgggtat tttatacatg ttaaatccaa tatgtatcca taattatgat 14040
ctacaaatta agaagaagaa aaaaatattc acttaactaa taatataatt aataagaatt 14100
ttttaatatt taatatctat ctcctctaaa ataaaagtaa gaaataagat actaaaataa 14160
ctaaaaaata atttctgaag tgactcagat tcacattcta taaagaattt tttacttttt 14220
tcttttattt ttgaaggtac actagaacaa attgtatgaa gaaatatatt tcaaactacg 14280
ttcagagatg tctaatttca catataaaat tgaactattt ttcttttggt ttttatttgt 14340
tcttggagtc gttatcaaga ttacgcagtt aattcactag tcgctaaaga aacagaagct 14400
tttcactatt gtttatctat tattccgtct ctctttatga ttaatatctt tttgtttttc 14460
tcataagatt aattctttgt atcgctaact ataatgataa acaaacaaaa gttaggtttg 14520
gtgtaatgtg tttgtagtgg gttaggtcac acgaaagacg tgttcaaata ggttccgcaa 14580
ggtttttaac ggtaaagaag gaagagaagc aaagcaagaa gcatagattc ttggatgtat 14640
tcatattcct tgctttaagt ccttccgtct caattttaac aactatggtc acatgtccat 14700
actgatctcg taccatgcac ttgtcttcac atgcttcttc attttctatt tttgggtatt 14760
cgacaaataa atcgtgcatg gaaatgaatg tggtatcgtc caatgcagtt tacgagataa 14820
tatatatatt tttatttttg ttaaaaagta ataataatac acaattaata atatattatt 14880
accaaaaatt ataaacaaat attaattgca tgggatgaat ttctggttgt tgatttgttg 14940
gttcagacta ggtttgtatt cactagagaa cttcaaatat gctgaaattc gaccactcaa 15000
aagcaagtga gactctaatt gtcaagggaa atagaagacg ctttaagatc ggatcgttga 15060
ggattagctt gcatgaagtc tgaagatatc ttcaagaagg gactttgggt tgggtccgcc 15120
atggtagtgt ttttgtgact tacaccgaaa atctttaatt atatggagga atagtaaatc 15180
ttgctaagta atcccattaa cttattaatt gaatatattt ttatgttaat aatatttgtc 15240
ctaaacgaaa agtatatcta tttctctaat catcaaataa aacaatgagt ataagatact 15300
tacatattta atttgttttt cttgatctta aattagaatt attaattgat tcttttagtt 15360
tcaaatatca tgcaaatata gatggcaaaa gattcgagca tataaatatg gtacttcaaa 15420
ttgtgaaagt acgatttgat tttctctttt ctttgttgta cgtatgatat taaaagtaga 15480
ggaatatgat tcttgagtgt agaatcttgc cttctaccat ggttcaagtg taagcaatat 15540
aaaaaaggga gatgtgtgtt tatttcttcc caactttgat actcacaaga catcttttta 15600
attcactccc ttgcaaaatg gtggatcatc atctcaaagc tgatcgtgta gttgctcggg 15660
tagagaagtc ggtcaatttg gttataggtc ataggcaaac acaaaggcag gccggctcaa 15720
gggagtatga aggtgaatca aagcagaagt acacaactaa gaagatccca aaatggaagc 15780
ataatgattc agagagaaag ataggtcaaa agcaaaacaa tgaaacacca actatgattg 15840
tcgctggtgg atgggtcagg ccaaatcgag ccatgtgggc ttcacctcca aattcctcga 15900
gctccaagcc acaaaagaat aattaattat tgagagaagc tggtggtaac atatataaga 15960
actcaaatta aatgttcaag ttgggaagta gacaactgtt gagcgagaac aaggccagtc 16020
gtttcaaaac atccattaaa aactcagcca tggagggtgt ggtggcatat atatgtgtgt 16080
agactctaga tgggtgaatt ttataagttt attacatgta atattacatc atggaagttg 16140
atatgtctat atatatatac tgtatattgc gtgcctttgt aatatataga attcaataaa 16200
acctatcttt tttatttatt tatttctttt ttggtcagac atttttttaa aattcgtttt 16260
tcaactatta aaatgattta aatagataca tatatactta attggcaatc cataaaatag 16320
ttgaattgtt ggaattataa tctgaaatcg tacccgaaaa ttcaggtacg aggcatatta 16380
aattaaatat cctaataata agagttttgg gcaacatgtt tatcaagaaa attgaagttg 16440
tatgaagtgt atgaactcaa cattttcgag aattttagtc gccatttgcc atatataatt 16500
caacttgtaa cggatcgtaa ttaccacact taccattctc tgcattagct ggtagttcag 16560
atcgaatatg ttgttatata attttatttt tttaaagtgt atttgttact acttactagt 16620
atatgtatat cattggtgtc aaaaccatat agttccacaa tatagagatt ttgtcttcat 16680
gtcatcagtt gaaagttgaa ccacacttac tttttctggt gcaaaagtaa gataagaaaa 16740
acatttcaca ttggcaccaa gagatgctat attgcttttt attcacaaat gtaaattgtt 16800
tttcaggtca agagcgaaaa ttcctagaca tatacctttt tttaaaaaaa agtctatcac 16860
ataagttatt aattaaaaat atatttaatt cactaaagag aaattttgtc acaaaataaa 16920
aagcagtcta ccataagcta aagccactaa gtttacacct catagacaaa cttagaacct 16980
gaaaaaagaa aaaactcttc tcagttggtt tttctctttt caagagtcga agtctcaaac 17040
tcttctcagt tgctagcctt gttagccttc aaagaaagct gctagtggtg taaggtcttt 17100
gttacactgg tgatgaagaa ttccggtgag acacctttat atagtcgtgg ctgggtttaa 17160
tgaatagact ttcactcaaa attttgagat tttcggaaat ttttgactag agaggttaca 17220
aatgatccag tttaaataag caaaacaaat gtagtaaacc actattgaaa aagtgttatt 17280
tcggtttatt taattagtta gattgtaata ttgcaaattt taaaattatc taaatgttcg 17340
ttattttttc aataacatac aatgcgtgag ttcaaatgtt gatgttattg caataacaac 17400
actaacaaaa accgctaaga ttatgaccca tgcacattaa tacatttatg ttgagaatag 17460
tctgattatt aatatttaca tgttattcaa catacaatga aaataaaatg gtaaaaatgt 17520
atttacacat agtaaattga tgcgtacaaa atgaatgtaa attgattaca gacataacag 17580
aaatgacaac gtaaacttta taataacaca ataaaatagt aatcaaaatt atacaattgc 17640
acgaataaat tttctgaaat tgttttcgta taaaaaaaat ttaaacagta aaacataatt 17700
aaatgtaaaa aatctttgtg attttttttt ttgtaaaaag acgtagtaga atttacaaat 17760
taaatttaaa aggcataaaa tgtataaaca gataaaaaaa catataaaga tttcttaata 17820
ttttgcattt tgtttcttgt caataggttt tattttccaa cctgcatctg ccaaagcacc 17880
caactccacc tgacttgtct gtgtctgttg cgttcacttt cattggaatc tcagattttt 17940
tatttttttg tttgttttgg ttgttgcgag tttgtgacta taaaacctct cccacttggt 18000
tcttcactct cactgtttct catctcttcg tcttctccgc ctccttcaat ctcactccga 18060
tctctctacg attcattcgt tctatggctt ccattgctgc ttctgcttct atttcccttc 18120
aagctcgtcc tcgccaactg gtctctctct tccctcgaat ctctcatctt gttttacttg 18180
ttttgctgta gatctgatct gattgattgt tgttcttctt cttcaattgt agatctaatt 18240
tgcagaatcg ttttctgagt tctaggttga tttgtttagg tggctctatg atttagtttt 18300
ctggaacttt ggctctgtag atctgatgaa tctgttttac tattctccgt tgctaatcac 18360
cggaataatt gttgatttct cgtcgaattg aatcacatag attttagttg cttctgttta 18420
acttctctcg tagattgttt cgttattttg gtttgatgct ttgcattacg agtttaactt 18480
tgtactgatg gcaggcgatc gcggctagtc aagttaaaag ctttagcaat ggaagaagaa 18540
gcagtctttc ttttaatctc cgccagcttc ctacccgctt gactgtttcc tgcgctgtaa 18600
gactttgttt tttgctttct cgagcctgtt caacaatgtg attaggctct ttgatacgtt 18660
tgggtgattg gttgatatat atctccattt ttttattgtt gtgtaaacag gcaaaacctg 18720
agacagtgga caaggtgtgt gcagttgtca gaaagcaact ctcacttaaa gaggctgacg 18780
aaattactgc tgccaccaaa tttgctgcac ttggtgctga ttcccttgat acggtatagc 18840
ttaacaacct tctcgatgtc taataattgg attcaacttt tgaaatggga ttgttcattg 18900
gacttattga tgcttaatca atgcctctta aaaattgtat cctgctttca agctcatatt 18960
gtcgaatgtt ttagattgca agtcttgtaa agggtcgctg tgtctcctta tacgcagctc 19020
tttagtattg ttactgatac aggcaaatat ataggacata ctcaaacaca tacttcacaa 19080
gcaatgcatt tatcaaattc aaaatggatt cgaacgtgtg cacatactca tgactcggcg 19140
ttttggattt caggtggaga ttgtgatggg actagaggaa gagttcggga ttgaaatggc 19200
ggaggagaaa gcacagtcaa tcgccacagt tgagcaagca gctgcgctca ttgaggagct 19260
cttgtttgaa aaggccaagt agaatatctt tattacatta gcaaaaacga aaaaaatcaa 19320
aacccaaacc actatcttat tgtttcgtta gctagagagc aattgtgtct gttgaaagat 19380
tttatgttat tttggggaaa ttattacaag gcttgtatct gacttttatc tttcttctaa 19440
aacattttac tttcagcctt catcaaactc tcttacgaaa cttatgtagt ctcatttcct 19500
aaataaagat gtttttccct ttgcttattt ctctgaaatg tttcgagaag taactgtgaa 19560
actcgaaacc tcggagtgta attgctccaa cgtaaaaaaa cttgtgtgtc gtcgtgggat 19620
ttgtagaaat gaaagggggt gtattgtaca cgaggcacgg gctaagaaaa aagactagag 19680
ctttcatttt agcgttaacg ttaacaatat tgtctcttca aatgaacttg tccccatgta 19740
aagtgaagtt ggtaattttg ttgttgtcct tcgaaaactc ccctctcctg gtgaagcagc 19800
aacttgaaaa agtctttagc attgtggtga tggggtgaaa tgtaaatttc tccatctctt 19860
gttctcatct ttcacaagag aagttaagaa ctagtaagca gtaacacttt tattaggatg 19920
aacagatact ggacttaaaa aggattaaag gcatatagaa ttaagtttac gctttggtga 19980
tgttacaaaa aaagatacat cgtttaatca attatcttag aaagatttga aacaacaaaa 20040
aacactaaaa aaaaaaaaac tgtacgtagc actagatttc gttcagagaa ggcatgagcc 20100
agagtctctc ctcggagact cgttcgcgat cagcagcaaa gaatctctct tcagcgagca 20160
acgaatgtaa attgcttccg ttggctaagc tattgaactc aatggattta gaaggcaaag 20220
ctgaataacg tcgttgacaa aatgtcatca atcttttaac tgactgaaga tacttgcgag 20280
tggtttcgtt attcatgatg tgagcaacac tactgctagt agaaatcttc tctcgggcag 20340
aacgttcgtg aataccaacc atagtcacac cgatgggcca tggtgcgttc cctatggcta 20400
gtttgatgaa ttgagccgtt gcatcgaggt aatctcgctt tatccagcag ttaaccatca 20460
ccattaaacc ttgacgaatg tcagctggta aacactgcaa aattttgctt atatatatta 20520
accctaataa gacacaaaag ataaaaattg cttgctttgc acggaactaa aagaaaaaaa 20580
aagatttatt tagtttacct tgttccggca taagtggaag agaggagtta gatacctagc 20640
acactggtta aaagtggcta gcatctgttt ccctatagca gttctcctct cagtgttttc 20700
catagcctca agttcctgct tccattcaag caacagcttc ttgcagaaca caaggatctt 20760
gtcctcgtcg cataaatcct cgaaattagc ttcttccaaa agcttcaaat cctccttctc 20820
agcaccaatg agctcatcat cattactcgt cttcctcttc ctatcattca tgagaccact 20880
actcctctcc cgcttcttga gctcagtgat gtcacgcaag aaatcgtttg tctctccttg 20940
agtcatgtcg ttatcgacct cctcgaataa tccttccttc aacacgtact tgagtcgatc 21000
cagccgcacc tgatcacaag atttcaatgc ctttgtgagt tatggtgaca agtattcgaa 21060
tctgatagag tgttttgctt agaccaagtc aagctaacta ttgataaaag ccacggtggt 21120
gtaggtgata cgtcttattt cacatcatgg attgatatat actctagtaa agcgtagcat 21180
cacacatcta gatgttaagt gtctgatctt ctagattttg agtatcatga gatgccccta 21240
accttttata tctgcaagac actcgtatac ctaaaactgg ctcgggtgag ctttgatgat 21300
gtcgagtttg tttctttacc tcttctcaag actatgcatt taaaagataa tatgtatccc 21360
aatgaagcca cttttgagag acttgtctca tcctgttccc tctcggaaga gttaaagatt 21420
gttgcatgtt tgaagcataa tgcgaaagtc tttcgggtgc tctctaggtc attgataagg 21480
cgcattataa gaatacgctt ttctcggcat gattcgggtt caagaattgt gattgatgct 21540
cctcagctat gctttttgag catttgtgat tacttgccag aaagctttag attaatcaat 21600
atggatttca atgccaagtt agatatttct cttgccttcc catcaatgag aaaaaacatg 21660
cgccgttttt tttctcggaa tttcgaaggt cggagatatg acgatatggt caaagactat 21720
aaagctcatc cacgaatatg tgagatttga accacggcct cgatttggtt gtgtgtctcg 21780
cctgtgtgtt actctctgtg atttgaaatt gttgccatct tttctcgaga gctgtccgaa 21840
tctgaagtcc cttgtcttga aatgggaagc tagcttaaag catttggagt tgatgaattc 21900
attcggattt tcatctgcgc ccaagtgttt gttatcgtct ctcgagtttg ttgatttcga 21960
aacgaccatc ttgggatatt attcttcaga gatggagctg gtaaggtact ttcttgagaa 22020
ttcggcaatc ctaaaaaaac tctctctacg tttgcgctat tatgaaaaac gacaatatga 22080
catatatcta caaactcatc aaaatcccaa gacgctatat cacatgtcat gtcgtcgtat 22140
cacactgttc tgaccagttt atgtgaagac tattaagtta taataatcca ctatcacgaa 22200
aaataatcca ctatcacgaa cgtagttatt cattctatca cgaccatatc actaatctaa 22260
accaaatttc tagtgataag aacagaatga tatatttaaa gctaatagca acaaaagaag 22320
tagtgtatat atataataaa tatatagtta caaatacatg aaagtctacg caaatttgaa 22380
aagaattaaa acattttctc ttagaggaag ccacaaagaa tagagggtaa acacttacat 22440
tgttatacat gaagtagtaa acactttctc ttctcaggcc actactgctc tctttccttt 22500
actgcttttg gtgttatctt tcttctttct tgaaacgcct gtgattggat gacccagagg 22560
acctgaccac gtctggactt gtgttggtgg ttcgtctttg gaaaaattga aagaagagga 22620
tgtgaaggat gggaccatat ctcgtgggat aaatgtcggg tctatatgct gtgaggcacc 22680
caatggtaca cccattgctc caccatcttg gtgtggtggc ggaaacttct cgctcttgct 22740
ctttgcattt gcgtgtgtga ttaatctcct tctctgcttt ttaagagtca aaagatagaa 22800
atgattatgt aaaaaaagga tcagtctttg tgtgtgtgtg tgtgtgtgtg tatgtagata 22860
tgctagaagc agaacattag tgaagaatca ctgtcctaga agcataagca ctggtggtat 22920
aaaaccaata ttcagcttac ttcctaacgt agacaatagc ctaaatgcac cagtatatac 22980
agtaaaacct atctataaca acagtactca cctagaagca acctgattcg agtcagagga 23040
ataaatgtag aaaagaagag acgttatcga aaagaaaaca gttgggaagg acatacatcg 23100
acatttgact gaagttctgc attagcttca ggagctggaa gagctcgatt tgaacgatct 23160
ctgtgccgat tcttccttgc accatcccct tgggctttac tagcagctct ttgtctgcac 23220
aggagaaaac tgttagtcta tgcatgctga caaatacagt ataaaatagc tacaagtaat 23280
ggtaaacgca acaataatat cggaatttct aaaattaagc atgctgacaa atctggatgg 23340
tctatccagc caaagttgaa gcctaaattg gtatctggta tggtcggaaa agctctccat 23400
taagaaaatc gagaggcaca actaaatacg aagtgggaca tgtttttttt tgtggttcat 23460
tcctacccgg aaatagtata tgaatcatga ttaaagtgga gtacaccaaa atatacataa 23520
catttcaacc atttgcatct tcagcaaagg tcatggtaag attcatatat gctgaacatg 23580
aatattcaat catattggca tgtcattcat gcccgaaaga attagaaatg tatttctcta 23640
gtttcataag aaacagacgc tatcagttga ggttagcgat gattaaaaca ctacagagaa 23700
aatgttacaa acctccgagt ttcttcatct cgtcgctttg catcaatttc tttgctcggg 23760
ggatactttg gcagatcagc aggttcacag gcatatggtt cacttgtaaa gaactggaaa 23820
ggaaaaattg cagagtaaac agattcaaat ctgctcagca tcatcagaac aatttatgta 23880
aattagcaga aaaatcaaac ctaagaactt acttcacttt ttaaagcagc agatgcagtt 23940
tggcggtctt ctggctcgat tgaaagaaga gcgtcaatga gcggaagaga tgatggtgga 24000
aaatctttaa atgtctctct tatgcttctt ttgtatggtt cacggggttt gtatatggct 24060
ccatgtgtga atttcccttt tttccaataa tcctctgatg gtgaaccaca cagcttgtaa 24120
atcttatgta gctgctctac ctatttcatg atgaacataa gcatgcatac aagcagattt 24180
tagatactag ggaaatagag gacataactt gcatatggag ggaaatatta agatgatgga 24240
ttgataagat acctctgtcc gaccgggcat aataggtctt cccgccaata gctcagctaa 24300
aatacagccg gcactccaaa gatcaatacc tacaccataa tcagtagccc caagcagaag 24360
ctctggagct cgataccata gtgtaaccac tcgactagtc attggccgct tgtgattagg 24420
atcaaaaatc gttgcgagtc caaaatcagc aatctttagg accccaccat catcaataag 24480
aagatttgat cctttgatgt cacgatgaag tacaccacga ctatgacaat gctccaaacc 24540
agatatcaac tgacgcatca aacatttaac ctgcaacgta aaagagtaat ctgatcttaa 24600
aaaacgactg aatattatta gcctataaat ttagaatgcg agatactaaa acgcctaact 24660
aacctctgat tctgagaact taacaacagg acttgaagca agaccagcca aatcatgatc 24720
catgtattga aatacaaggt ataagctaca agacattctt gacgtaacca aaccttccaa 24780
cttcacaaca ttaggatgat caagtctccg caacacaaga atctctctcg ccataaactt 24840
cacactttcc ggctccaagt tatcaaaccg aaccttcttc aacgcaacga ttttaccggt 24900
caacatatcc ttagctttgt acacattact atatgttcct tgtccaatct accacatcaa 24960
aaacaagata tctccaaatg agaaacttca aaaacaccca aaacaaaaac agaaagaaca 25020
aagtaagagt cttttcatga atcaccttat caattttctc aaaagtatca gcctttctag 25080
gaacccaacc atttaaagct tcaccacaag catcagaaag ccaagaaggc caaccagcag 25140
caacctgttc accacgccaa tgcttggaag gattactcaa ccgcggattc ggctttgtcg 25200
accttcttcg atctcctttg gatgatttcc tttctttatc accatttgcc tcctcattct 25260
tcttcttctc tacatcatca gcaataactc cattactctt agtcacacta ctctctccta 25320
ctactactac tccactacta gctttagagc tcttagcttg tttagcttca gctgttgttg 25380
ttgtcgccgc ctctcggcca aatacacaac ccataactta aatctcaatc taagcttcat 25440
ttctcaccat aacttctacc aacaacctac aagaaaacca tcacaactat ataaaatgaa 25500
gtcgatctaa tcgaagaaaa cgaaacccta attaatgatc ttgaactcca ttgaaagaaa 25560
gaaaaaaagt aggtagaagt tgaaatacga ataaaaacct agtttccaga atctgattga 25620
agaacttttg gagcttgaaa ctatctctat ggtgagagag aagagaagta ggcgagcgtt 25680
tttttttttt ttttggttgg gtcttactga tttggttgag acagtcaatt taatttcctt 25740
ctgtttttaa ttctttttta tttttcttat taatgaagat gacaaagaaa gaagaagaag 25800
aacgcagatc tctcttcagt tcagggtcaa actcagataa ttaattaaat ataaataaaa 25860
tagaaatgat gtagaattgt tttttttttt aacaactaaa ttagtaacag taaaagtttt 25920
tatgagttga ttttttattt tgaattacta agaggtttta tgttcaaggt catatatctt 25980
cagctatata caagtgggac taattggaca taaaaatgaa gaatgtatta acatctcaat 26040
agtcatccat aactaaggaa ttgaaagctt attttcggat gaaaatttaa tgttatgtgc 26100
gtattctcaa tttcattaat cgttcaaaac agataaaata attagtatta taccgaaata 26160
aaaagtgact tgattgttta cctaatcaca aaatttgcaa aatgacacag acttccatat 26220
atataattgg gtcttgttga ttttttaaaa gtttgtaaaa tatgttctag agaagtagta 26280
gtgatcagcg ttatttcaac tcttttttcg tacacatgtt ttgtaggaat tgtttgatgc 26340
atatgtaacc cccttgtcgc gcatgtgtac cttccacatg agtgtattgc agcagcccaa 26400
aaggaacata gtacaagaca aaatgcacaa ataacattct aagaacttca tgtacaaaaa 26460
tagaagcgct ggtatcaatt ttctacttgg attctttttt gtcctttaca ttgcttaaat 26520
tgttatctaa ttatcatcta tgtatacatc ttgagagaga gaagacataa catgtatgtt 26580
tgggacaaat taaaaacttt aattttttat aataacatgt ttcatgtaat atcattgtaa 26640
agcatcttat atgttcttta tatctattct gcaatagatt ttatatgtaa tgtgttcaac 26700
aaagcaataa attaaaaagc tatagaatag tgacgctatg ttaatatatt ttttaattat 26760
agtgacataa aaaactataa ataacttctt agaaagagtt ttttatctac tgtgctaatt 26820
tgttttgtat ataatatttc ttttattgac tattattgtt ttgaatgatt tctttaaaga 26880
ctactaaaaa taaactcggg ttaacatcca ctattatctt ttggaatgtc tttatttttg 26940
ttgaaatgtt atttttgtca atagtgaaac atattgtaat tgttgtttat tcaaatgttc 27000
taggtatttt tttttttaaa aaaaaaagag aaataggcag ttgcacttct taacactttt 27060
agaagtatga ttggatataa aaatataaaa ttaaactgta aagacttttg tagtgaagta 27120
aaaattctca catcccatta acaatcaccc cagtaaattg attcttacat tatttttttt 27180
tatctaagtt tgtatatata gacttttcaa atctatgttt aattcacatg ttagagttat 27240
agaagtcaaa agtcttttta caatgtctta tagcaaaatc ttctataggg tgcaaagttt 27300
gctaacttag tttaccgagg tttgaccttg taatttgatt gtgagcaaag aaagtgcaaa 27360
actaaacttc tcatttatta agatatgtta aattcgagta ttatgatttt caaattcaaa 27420
cttagtaaca cattttaatg tgtgattgtc ctttgtaaaa tatgacatcg cacataaata 27480
atattatgaa ataattctag agtaatttta cttttatcaa catttattta aagaaaatat 27540
agaaaatcac aaaaaaatca atgagggtag gattttaaat atattttttg attaacagat 27600
aaaataaata aattcgttgt ggcattttct aattattaaa aaactcaata aactcattag 27660
actagaaaca gttgatatgt taaaaaaagg tattcaacag ttgtaaagaa tgcgatgaat 27720
atttaataaa tgattaaatg ttgtaaaaga agtaacaaac ttggagtttt agtttatcaa 27780
attttgttag gtatctagct ccattcacca caaaagataa ggattaagga ttgaaaagaa 27840
gaaaataagt gttaatgaaa aaatatgtaa gaatcattta aaatgaaatt tttttgacac 27900
acttttcatc tcataaaacc acaaagccgg ccctaaaaca taaagttgta tgagaattat 27960
ctttatcttg taaatagtga agcaattttt aattctttag acggtaaaat tcaaaatata 28020
caaaataagt gacaaaagac atctttttgt aggtatatat atgcctttag tcaagtgatt 28080
aagttcattt gactccgcat ttctcgtcgg agtttgactc tattacatcg cgtaattccg 28140
cgtactagga attgattatg gatctggcct tgtcgatcca aatatgtaaa aaaaaaaaga 28200
catacttttc atagtgtttg tcgtaaaact aattaagtca aactttttgg agtaccgcac 28260
caatcatgtg tcttacacac tgggagaaga catgagaacc aataagtagt gtcggtcgca 28320
gcgttactat aaatcatatt ttatggcgct taaaaaaata ttttacagta tatatcaaaa 28380
taaatttgct aactacccca aaaataaatt tggctagaag ctagtatccc aaatattttt 28440
ttgacagtta atataaaaaa attagaaatt ctaattaaat cataggagtg aatgatgtgc 28500
gttttatgtt tcacttaaaa aagtgatgaa caatatcaac attaaaatta tctcaatact 28560
tatatgaaac tttttgtatt tttttaatgt ttcttagata ataatttata aactgtaggt 28620
attttagatt gacttatttg atctatatac ttttgtaata tatagcaaaa atatttgctt 28680
ttatcaaaaa agaaaaggaa aaaatgcaaa tgatatgaac tggatattct atgagtagtt 28740
aatccatgga tataatcttt taatttaaac cgtaattatc atgttgatta tgagaactaa 28800
acaaaacatt ctcaacacat gcacacacat atatattttt agtaaatact aaatatcatt 28860
ttgattaaca gatctaagct tgtctttcat aacttttttc aattaaaata aaactcatgc 28920
aacctccggt tccttttcag gcgctaatct aaccatgtcg attcatatta aaactgtaag 28980
gaatattgat cacgtcgaaa agaacatcgt tttctttctt catcggagat atttgtttat 29040
tgtcgccgtt gaatcccatt tcgcaaatgc ttggtgcttc ttttgctttc tgcaaatgaa 29100
ccgaaacttt aaacagatct ctcactttaa tgtacttcaa agctgaggtt aacgcgtcat 29160
agccttcaga ataaagctta aggcactttt gcaacaactt cttactcagc ctgcccttat 29220
attttctctc gttgaaaatc ttctccacaa ttcttttcac gtttgttagg tttgataaag 29280
cgttattcgt tcctaccaat gttaaatcat tgctattcct tgctttctga ctttccgcat 29340
tctcttcgag agatgcaatg caaaacttat agaaatatcg ttccgcgtac tttgaacttt 29400
gattgcaata tttctgaacc agagagtttt ccactctgtt ggccgtcaaa ccattgaaaa 29460
gaagaacaaa cacaacgagg taaatcaaga acttcattgt ttcttttttt ctttggaagc 29520
aaaacattag aggtaataga ttgaatagtt atagtaacat gtgatcctat ttataagcaa 29580
cacagaagtc ttctaacatg agagtgttat tcaaacaaat gcttttttta gatgactcat 29640
gtcatgcatt accactccgc ttacttcgtt gccttctttt gtggtcaatc ttcattgcct 29700
aaaaagaatc attactctag acatttcgat gatatctcta atttcgtttg attcatagca 29760
aaaatatttt ttttaaactt gcatagcaaa agaagtgagg taagaaaaaa aatgtttatg 29820
ccccttcccc tgaattttgg aatcttcgga caacaaaact tctagattat aaagaaacaa 29880
aaaaatgtca agcactcaaa tctttcatta gatcatcaac catattatat tatttaaaac 29940
ttatgtttga ataccagaaa gtactaatat tttaaaggtg aaagtaaaat gtttcagacg 30000
aaagtaaata ttaaaataca agccttgtaa taattatccg aaaatagcat aaaatctcaa 30060
cggacacaat tgctctctag ctaaccaaac aataagaaga tagtggtttg ggttttggtt 30120
tttttcgttt ttgctaatgt agtaaaggat tttctacttg gccttttcca acaagagctc 30180
ctcaatgagt gcagctgctt gctcaactgt ggcgatagac tgtgctttct cctccgccat 30240
ttcaatccca aactcttcct ctaatcccat aactatctcc acctggaacc ccgacacacg 30300
aagcatgagt acgtccataa caatataaca agaatcatga gtatgtgtat ctcagtaaca 30360
tgtttagaga tgtgtgtata aggagaagca gcgatccttc acaagacttg caatctaaac 30420
attcgacaat atgagcttga aagcaggata caagtttaaa gaggcattga ttatgcatca 30480
ataagtccaa tgaacaatcc catttcaaaa gttgaatcca attattagac atgagaaagt 30540
agttaccgta tcaagggaat cagcaccaag tgcagcaaat ttggtggcag cggtaatttc 30600
gtcagcctct ttgagtgaga gttgctttct gacaactgca cacaccttgt ccactgtctc 30660
aggttttgcc tgtttatcaa caatcaacaa tggtgaatga tgaattggct cgagagatca 30720
aaagtaaaat agaaacaaca tcatatgaga gaagagacaa ggtcttacag cgcagtaaac 30780
agtcaagcgg gtaggaagct ggcgaagatt aaaagaaaga ttgcttctgc ttccatagct 30840
aaagctttta acttgtttag ccccaatcac ctgccatcat attcgaatat aactttccat 30900
cagtacaaaa ctaaactcca aatgcaaagc aatatatttg cactgaaaca aaccaaaaga 30960
aggaaacaaa agcaactaaa atctatgtaa cccgcatgct cttaccaaga gttcgaatct 31020
attcaaattc agatataaaa caaatccaat tcgaagagga ataggataat ttttccggtg 31080
attcgaccga gttaagtaaa ataggttcaa cagagcctaa aattccagaa aacgaaaact 31140
aacttacctc aatgcaaaaa aattacagga caaaaaatga attacagagc aatttcaaca 31200
gatcaatata gagatgagaa aacgattctg cgaattagat ctacagttga agaagaagaa 31260
gaacaactag gtcgagatga atcagatcag atctatagca aaatgggaga aatcacgaca 31320
aaaattcagt aagaaaaaga tgagagattc gagggaagaa gagaaaagag agaccagttg 31380
acgaggacga gcttggagag aagtagaagc agaagtagca atggaagcca tagaagaatg 31440
aatcgtagag agatcggagt gagatcggag gaggcggaga agacaaagag atgtgagaca 31500
cagtgaagaa tccaagtggg agacttattt ttaattttat agtattttaa cctaaacaaa 31560
aaaaaaaaaa aaacttttct gagattccaa tgagagaatt cagacagaca agtcaggtga 31620
ggtgggtgat ttggcagatg caggtagaga aataacaaat tcggaaaaaa aatccaaaca 31680
tattgttttt tttcttaaag cgaaataaaa caattagtca attacgatag tttactggaa 31740
ttataataaa caaccttctt aacttttttt ttatgaaaaa cacacgataa atcataaacg 31800
taagaaaaat taacatgtta tttctatacc ttaaaacaaa ttaatgcatc tttcatattt 31860
tttaccaaat ttttacaact attttgtagg gaattttcta ctaatttcct accaaatatg 31920
aatagtaaaa atttgatagt aaatttcttt taccaatttt ttttgtaatg ataggattaa 31980
tatgttccaa acaaatgcta gatgttaagc taacggtgat tcaccgctat aaatgctaag 32040
cgaacggtga tccatcgcct attgcctaaa acatctaacc gagatataga ggatttttgg 32100
cttaagcgtt taaatcaaaa aatttaaaat atctattaga atctgttatt tctgttttca 32160
tgtgtctgat tatgcacaat agtggaatgc ttttttattg ttcgatatat catttattta 32220
tacgaaacaa cacaaattaa cttttttata tataggatca tatttatagt ctttactcag 32280
taattaattg ttaaaataca taaacttata cagtttattt tttcaaattg aatgaaataa 32340
ccataagata tttgttgcat acttaattag aaccaatcta taatctcctt aatcttgaca 32400
taactagaaa cgattgtcat atatactcat acatctaaac cctttcaaag aaccaccaat 32460
tggaacttca gtgaactcct ctcgcctctc gttatacact ataaccttgt cttctcttct 32520
tccattacct ttcaccacta ggaagagttc ttcgtttctt gctatgcacg caaaaccaac 32580
atcaaaattt ccgtttctat ctaagcacgc taaaccaaca tttaaaatgt tgaacgcttt 32640
aacattttcc ttccacgggt cgatattcca atgcatgatc tccttgcctt ttctatgcgg 32700
acgccataga caaatgtcat tatttagact tgggtaatga tcgataacac atagctctcc 32760
tcttaaaacc cctaaccatg aactgtattt cgactccgtg tgcataggag ataatagctc 32820
ttggtactct tccttggcga aatcgaaaca gaggatggtg tttttcctac gggggttttt 32880
ggtgtgagac ctgtctgcta tccacaaccg taccggtccg gtctatgaat ttgcgatgaa 32940
gagaagtatc tggtacactt tctctccaac agctttcttt gaaagcatag atataggttt 33000
tgaaaccaat tttcgttaca atcttgtaat cattagaaat ccggtcataa ccaaatccca 33060
atagatttgt ggtttggccc ggtataacca ttggtattct cttgaattcc tccgaacctg 33120
gtttccaaat cgctaggtca ttgttttctt tgagggtcag acacatcatt ccacgacaat 33180
gaagaataca gacaggttcg gtttcggccg gtaatgtaaa gggcaagtct agcttcaaca 33240
acgtggtttc gttgaggttt agacggtata aaccatcttt gtgtaatgaa atgagatgtg 33300
atgattgttg attcgacata ggaaaattga tcaaaacaga tatattttgg tgaaaatcaa 33360
gaaaaaaaaa ggatattgat tgcttatttt atatagagct tatgactatg aacaacaatt 33420
cattttatag attgcttatt tattaatatt gagagcgtgc ttacatgttt aactaattgt 33480
ttagttatta gttattactt ctaaattgtt tatagatttg gaaatctgta tatatcaaat 33540
aaaatttatt atactgccac ataagcaaat acaatcttta aaatcagcct catcattaaa 33600
agaacaattt tttttgttga acatatcatc attaaaataa ctatataatt gatttcttac 33660
ttttttcttc agtcaatata attatttact tgatttgctt catttgtttg tttattgaaa 33720
ttatcaataa tatcttagtt ttacctaaag tttggaaata gatttttgag tttaaaaaat 33780
atacttttta tgatttttct cttatcaaat atctcaattt ctttgatata gttttacaaa 33840
tttgattcgt gaccagggat gggtgaattt gaaggtatgg ttcggatttg ttcatctaaa 33900
ctttaaagat tataattaac ttactcttag ctcaaaagtc acacgtttgt caataacaga 33960
gtgtgctcaa ggacgtctat catcaagcac attagttcaa cattagcgta tcttgagaac 34020
aaaaattcca atatcttcaa accaacatga agttcatgaa cattgtgaat tgcttgaaga 34080
agagagatca tgaaactcaa agattgtttc gcaagaaaaa tcttacacta aaaaaaacga 34140
atttagtttt gatctgcaat gatttgacga ctagagtctt atgaatatgg ttttgaatat 34200
atgaacaagt gaggttacaa ttagagaaca aagaacgtga acttagtatg agaggatcag 34260
tgtaaagata atccaaacac tagactctgc aatcttcttc acagatagag cattgcgttt 34320
caacttaatt agagaagggc ttttggaact tcccatgaac ccaaactcgg tacatgtcct 34380
taccctttct ccggtttact gctttgacac aacaatattc aagctcaacc tatacacgag 34440
aatcaaaata tcataagatt tgttattcat tcaatcacaa caaagaatag aaaaactgaa 34500
aaaagaaagt ttacctcaat gaatccagca tcagtaaata gtttcctggc agtgtcgaga 34560
caaaagaaat aggaaagggt tccatcagac cgcacatatt ccctaaatcc tacacgtttc 34620
tctggctcaa accgtagcat agtcatgtca tataatcctg tcaaggtgtt tagcctatta 34680
gtttctcttt atttgtaaac atatgtgata cagctcttaa tagtgacctt accataatct 34740
ctaaataaga gcagaccacc aggtttcagc acagcaaagc attccttgat agctctcggc 34800
attctttctt taggcactgc cgacaatgta aatatctgac ataacataaa aagttggaat 34860
aacaaccgtt tcgattagaa atgttcacat agcagagcat ataacacatc tgtaaaaagc 34920
ctaatagcta agaatcagat catagaagat tagaaacata aatttcagtt tcacatctat 34980
cttataacca cattataaaa accatgagat caactactct agttccactg cagaatatct 35040
gacattactg tttcctacag tgagcattgt tattcctctt aactaaatga gcgatgttca 35100
cataccagag tgacaaaatc caccccaccg atgcaatgtt tgctctcact ccctcctatt 35160
aatgaagata tacaagatta gctaggacgt gtatgagaga acaatgtgta tggataaatt 35220
gctacagaga gaccaaaacc tgagtggtta agcataaact tgtctcgaca acgatcacat 35280
gccacccaat ctggaaactc agaagtcgaa aagtcacaac aaaaagaatg aaagttatca 35340
accgaagaaa tagcgcgatc aatgttctct ttagtcctaa caagagcgtc actgctacaa 35400
tcacaagcat acacagtaat gttcttgctt ccactacaca aaaacaaaga taaaacacat 35460
aaaggttaac tccaaaaagc taaatcggaa gaataatacg gcgaagatcg aaagaattat 35520
accgtaaaat cggaagcacg gtactgccat taccacaacc aatttccaaa agttttgagt 35580
tctctccaca agaaactaat tcaggaaatt ccttcaacag ataccttctt tcctacacga 35640
aaaccagcca gccaagacga agaaatgtag gaccccgaaa tccagattta aaaacactca 35700
atttctcatt caaaataact tcaattttta catctaataa ggctcattac gaaggaatcc 35760
aaagactcca tgatccggtc attccggtga tgaacttcac cggaaaaccg gaaagttggc 35820
cggagccact tgtttaaaat gttccaacaa taacatcatt cttacccaaa tcctaagatt 35880
aatcaatctc tctacatctc aaaaaattca gaagcaaatt tttactacta attcaaactt 35940
ttcttcgatt gtaaatgata agagctgatt acaagatatg gagtagtgat gtgtgtgtag 36000
taccttgaag aattttccgg aggagtgacg ggagtgaaaa tcttgccatg gctgcgaatc 36060
tggtaaatat ttggagagat tttggtggtg gtggtggaga tggtgggaga gagaaggatc 36120
gttctcgacg atgttcttga gaaattccca ttcgaaatct ttggaatgat actctcctgc 36180
ttcttctctt ttctccattg tttgttcaat gcctgcaagt attttctctt ttgagaagta 36240
cggaccggga aaaaccatac taaaccgaat attttttaga aaaccagtat atacggtttg 36300
attgaacgat ttattagggt tttggctttt gggtgttcaa ttctgattcg gtttcgtttg 36360
atatggtttt tcaattttgg tttttcattt ttccggttca tgtatatatg gtttggtttc 36420
ttcggatcga ttttagtcgt ttgatataga ttaaaatctt cattaattgc acatttatat 36480
aatgttactt ataatgaaaa aaattaaata aaacatgaat taagtaaaat aaatgaaaat 36540
ttaagttcgt attgtaccgc atcacaaaat taacatctcc aaataacaaa aagagatacc 36600
ctaaggagtg aagtcaaatt gtttaagcgc tggatgtttt caagttgaat tctaggtggt 36660
ctaatatgat atacccaata aattcaaact atagaaatca aaccatgctt attattgaaa 36720
ataaaactaa cacatattta ttcaacatgt acacattaga aacacagcta tacatatatt 36780
aatcttcgtc atattgaaga ttagaaacac acacaaaaat taaaaaaacg cacagtgtga 36840
tattagaaaa cggctaatat ccatccacac aacataaaac ggagaaacta aaaaacaact 36900
tgcactgtcg tatagttctg ctcaaataga tattctgtta aggaataaag aaaccacgtg 36960
atgtttcatc aactcaggat gtgtaaaaat gtcagtgtct ttgtacaaaa ccttgacgac 37020
cctcgagagg tttaggaatc gcatgacgat agggaaagca aaagagtgat ctctcgtcat 37080
cagttcttga ttaagactct tccatgaatc caatgccatg attttgatct cttcttcggc 37140
tttttcccat gaaataccat attgcttcat gtaacaatca atggatgttc ctacgtgctt 37200
tctcttatgt tcaaactgca ttagatagat ctcagatttt aaaattatct ttacaccaac 37260
gtggtgacaa aaattgtatt tgtatgtaga gtgtcaacta cagcttaagt tcttaggtct 37320
gatattataa ttcgaattct acaagaaatt ggatctcaat ctctcttgga atgtccaacg 37380
tcaaatatca tgttcttttt ctaatgtagt aatgtgtgtc attttctttt gtaacatgtt 37440
gctttctcat agtacatgtt atatactacg atcacatgct attccttccg aaagcatgga 37500
gacaaaattt tacacatgac attgtttttt tctttcagta tgacatgttt ttttttaaat 37560
gacattgatt tctttctcat tctttcggat atctctcttt cactgacaaa actcctgtct 37620
taattttttt ctcctttcag attttgtgtt attattattt gtttcatgtt tttccccaaa 37680
ctacatatgc tactgaattt ttgtcttttg tttgtggaaa tctataaatt ttctcctatc 37740
tttcctaaat tttctgattc atggctactc tggtcaaaat ctagttaata atataatctt 37800
ttagaagcaa tatctttgtc atttaggatc cgataggtca aactagactg gttattaact 37860
tattggcatc actacaataa tgtgagttaa ttacctcgca actagcaatg tcaccacaga 37920
gacggcctat tagtgcagaa gtcacaagaa ggggtgggaa agtgcttaac cattcaaaca 37980
catcaagggt gccttcatcc accatcccta gaaaggatcc tgttaacaga gctaagtagc 38040
tcgatgaata aactccgttc tctttgtact cgtcaaatgt tgccacaaag tcttcactca 38100
accattttgc ctcttgaaga taggctttag cagttacaat catctgattt attaacatat 38160
aaccaacaaa tttttcattt agattcaaca cacatgaaca tagacttagt acttaattac 38220
taattagttt tgtgcttttg aagtagttgt gtatataagt atttagtaat accgattttt 38280
tagcgaaaag gccgcatcct gaccttcctt ccctctccat atcctcctca agttttccgt 38340
agaaatctaa caccacatga tgaagatacc tcatgctctc cgggagccct tctatgccgc 38400
taggattcca cataatcaat gaaatggttc gagttcctca atcgtgccaa atgcatcgta 38460
cgtatcatca acaagagtca ataagataac aacaatggcc aatctaatcc ttgcttgaga 38520
atatcggggc tcaaagtatg ctccaacagc ccacaagtag ctttcgacag tcctattcct 38580
tgcatatggt actttcaagt cgagctctag atttgagtac cacctacaaa aaaagaagaa 38640
tcgacaatca ttatggtagt ctctccatat ataagagttt taaaatgtat atataatcta 38700
tcttgctagc tcataatggc acctgaagac ttggcaaagc tctttgcggt gcaaaatttg 38760
cagaagattg aaatctatct tagcaaattc tagcaaggtt tggtcgtgca gatcttcttc 38820
ttcatagtat gagatatatt gtcgtgtctc tatccttgat atacccctag ggtatgcatg 38880
tttgagggca tttttaatgc ggatggacat aggtggacta gattgatcag ccagtccttc 38940
caaatgagac ctagagaaag caagagcttc atcgagaatg tcttcaccat gggtgctcca 39000
atgtgcagct tcataaaggc ataaaagacc tcttgcatcc tcagctaggt gctccttgaa 39060
ctttccatcc ttattcttga agttgttaaa cacatcttac acatataatt ttttgttagt 39120
aatcaagttt aataattaac attgacttgg tagatttact aatcattatg cacagagagt 39180
acaaagtgag tataccttgc gcttccacag tattaatatg atcgaattag gtgaagttga 39240
aaaagaagaa aaaatacgct cgctatactt atgtcagttt tcacattaac caaaatgtaa 39300
tatagttctt agaccaaaaa caaaatacta ctaacaatta gcaacattct ctttcatgac 39360
tttttcttag taatatcaat tcaaattttt tttaacccaa aaaatatgga aacataaata 39420
agaaacttat tcatactgat aaattaatta acatattacg ctcgataatt ctaacattag 39480
agtgacttac cgacaccaag tttatagcca aattgtctaa aaatttggaa gacgagggag 39540
acggtgtata aatcgaactc attgcctctt atcatctgca taaaaccatg acaccaaaca 39600
tcgtctctaa ctgcgtgaag atgtctactt caaagtggta ggaaacacca aggcgacaaa 39660
gagcatcaat gaatttgatg ttctctatcg gctcttcttt tgaagccatt aacaatcctc 39720
ttacggtttc ctttagtgaa ctcagcttct cttcgtttat ctcactctcc tatatacatc 39780
aaaataatgg cacgagagaa gacatcataa tatagagtat attcatagtg ttttgtgaac 39840
aaatttgcct aattgtgact tcaagtcgtg tgggtacgta ccggatccaa aacagaaaaa 39900
gagatcaagg gatcttccca tatattcacc ggaaaatccg ctaatggccg atatatttct 39960
tcagtcgtaa gcgctgacaa agtatttatc agctcctgca tgcttaagtt ctttttctga 40020
ataaaagtgt atctataatc acacttcaag gttttctaaa gctttggtaa aactgtggct 40080
gcacttgata catatagagg ccatatatag ggagatgagc ctccctctct tcttttggtg 40140
tttctttttt tagtaacctt tatcttaatt ttgtttattt ctatggtatt ttcttttagg 40200
cgtgtaaaaa tgagtcattg attgggactc ttagccgaca cgatagatat gaacacattg 40260
gccattttac ttttctagta ctccctctgt tttaatatat ttctagttta aaggtgtttt 40320
tttttgttac aaaataaatg ttgcttttat atttttttat gcaaaaatta aatatattta 40380
atagttttaa ctaattatat ttaatagtat attttcgaat taattttatt tgataatatt 40440
ttataaaaaa tagatatatt aaagaaggtt tttatgtttt ttcttttaat ttgtatgaaa 40500
aatctttaaa ctataaatca aataaaattg agggaataat agacaagtga cagattttct 40560
tcggttacta aaagagcaaa atcaattcat tttaatattt tgacgaaaac aaaacaaaaa 40620
aaaaaatcat tttaatattt tatgtccatc agcccgttga attaggctta aatggcggcg 40680
acacattaaa gcttctttaa ttgcgccact aatatgatat gcgccactaa tatgatatcc 40740
cctacctcat atcaatcatt gtaagtgtca ttatagtttc ttacatatat taacataaca 40800
attaaaaaga aagggttgcc ttccatgcca agccagcaca tggaccgaat tgttactcgc 40860
tacagtgagg tgactggtga gatgggaaca agttgccatg atgtatgcag gtaagtgagg 40920
gatgaacgcc tgtctgtgtt gctgcatgcc tgcatgtgct atttgtttgt ttccaaggtg 40980
gtgtgatctg cccccgagga atgtctagga gaagggtttt ctgctgtgat tgctgaaggc 41040
aaataataat caagagtcga ggaacaaaat ttgtttcaaa taaagtggaa agaaattcat 41100
atttgaaact ccttcgtttt ttaaacagtt caacatttga tgtagatttt aaaaatgtaa 41160
attctattta ataggctgtt ctttttttta tataatatgt gaaatctata aaaattaaat 41220
aactatttga aaaaagcttt taaattgatt ataattttgt agtgggttaa aatctagaat 41280
gtcaataaaa atataataaa aaaaccgaat taaaaatcac taataaaagc cttcgaattc 41340
ataatcccaa tgctttttta atctttttct tctacacaat ttccagaaga tgattactaa 41400
ttagaacgaa atataaaata caaaatttgt ccaaaaactt ggagatgcgg gggatcgaac 41460
cccgtgcctc tcgcatgcaa agcgagcgct ctaccatttg agctacatcc ccagttgttg 41520
agttacaatg cttcacgttt tataaattcg aatatctaaa ccaacatgaa ctcttcttat 41580
ctccaagcga gccgcgtcat ggtgctcgga tctaaatctc cggtagaccg ccgccggaaa 41640
tcacttgaaa gagtggataa agaactctta agaggcaatt acgaaactgc tctctcactc 41700
gtcaaacaac tcaagagcaa acatggctgc ttatctgctt ttggctctgc taaattggtt 41760
tctctcgcat ctctctctta atgcttattt gccaataaat catctctaat tccttttttt 41820
ttttaattag cttccgaaga aattagacat gagtagcaaa actgatctca ggtcgttgat 41880
tgattctgtc tccagaagta ttgaatctgt ttatgtccaa gaggtacttt caatttttgc 41940
agtgttttac caataaacac atgtaatttc atgtacctta atttttttta ttttttttgt 42000
aggattcagt gagaacatcc aaagagatgg aaattaaaac ttcacctgaa gaagattggt 42060
tctctgttgt tcaggtgaag atctcttagt tgtcaaataa aactagaact taacattgtt 42120
gcaaagtgaa attttatcac aaatgttgtt tggtaatgag accaaatcaa atagaacttt 42180
ttgtggtgta cctttatggg caaatatata taaattgatt ttctgcgacg tctgcagcat 42240
gaatcagggc attttcttgt tggttacttg cttggagttc tcccaagaca ctatgaaata 42300
ccaactttgg aagctgttag gcagaatgtg tcgaatgtga ccgggagagt agaatttgtg 42360
gggtttgaat tcctcaaaca agtaagtagt ttgctcaaca aatggtcagc tttgtgtatg 42420
ttcccaacca caagagtttt atgttatcac cgcaggtcgg tgctgcaaac cagcttatga 42480
aagatgatgt cgacggccaa atgaaccaag gcaatatctc atccaaggta agatttcctc 42540
aaatggacct gtaatgagtg tttttcttta gctcaagctg tttctgtaat gattggtcaa 42600
atctgtgaat gcagacactg aacaactttt catgtgtgat acttggagga atggtaacag 42660
aacatatact attcggatac tcagaagggc tatactcaga tattgtcaag gtaatacaaa 42720
ctcaagtctc cttccactca tagtcatgag actataatct tctaatgtat tttttgagat 42780
ttgagtgttg cagttgaacg atgttctgcg gtggctcggc ttcacagaat cagaaaagga 42840
ggctcatatc aaatgggctg tttccaacac tgtctcatta ttacattctc acaaagaagc 42900
aagagtctca cttgcagaaa ccatggctaa agccaaacct attagcactt gtattgaagc 42960
cattgaatcc gctatttcaa cacatcaaat ttaactattt cacttcttca aaccgaattc 43020
attactggat ttgcaaacac agtttttgag taacatgaaa ataccaaaac tattgtggaa 43080
cagagagcca tgtctatgtt acaagctaaa aaataaaatt aaaactcttg agaagcagat 43140
ccgatatcgc ctttgttctt tccaaccttt gatgggagaa gagtctgatg aatgttgggc 43200
aaaactcctc cattagcaat tgttacactt ccaagaagtt tactaagctc ttcatcgttc 43260
ctcactgcaa gctgaatgtg ccgtggtacg atacgtgtct tcttgttatc tcttgctgca 43320
tttccagcta gctccaatac ctaatgatta tatcaacatc atataagaga tcagactcta 43380
gaagacacct taacatcaaa tcaaaatcaa agattcggta aacatcgaaa aatctagtga 43440
tatatcaatt acgagtgatt ctcatcatag agactaaaag actaaatacc aaacagaaga 43500
ttgtttgtta cctcagcggc gaggtattcg agaacggcgg agagataaac gggagcaccg 43560
gcaccaacac gttcggcgta tttaccggct ttaaggaatc tagcgattct tccaacggga 43620
aattgaagac cagctttaga agatcgagag acggactttg tagcttttgg ctttcctctg 43680
ccacctttag ttgttccact gccggcgccg gaactcattt tttgtttatc gggaaatttg 43740
aagaggcgat tgtaaaatgt gattagagat ggctgaggat tttgtgagtg gagtgattta 43800
gggtttaggt tgtgatttct gaaatatata gcgttgagat aatggatttt gattggttag 43860
ttgtgagtca cgcggattgc cagcgtggca ccattgtaag ttctcgcggg tttttttttc 43920
cgcctctttt taacaagtcg gtgaattttt taagacgatt actatttgtg ttaaaattcg 43980
gtttagaaaa aatgcaccaa aactataatt cggttcggtt tgaaaaaaaa ttaacatcca 44040
atgttgaacc gaaattagct caatttgttg ggtcatgaga taaatttcaa tcaaatggta 44100
gtgaaggata agcccaataa caaataacac aaacagcttt aacatgggcc aactaaaaag 44160
tgactgtcaa gcataatggt ggtgatgatg atagattgat agtggtgtag tatgacagat 44220
tgatagttat taaattaatt aagataatta tatgtatata ttctttgtac atttctgcat 44280
gtttttataa agtcaaactt aaaaagtcaa aacacttatg tcaaaaaaaa aaaagagtga 44340
acaactaaaa ctcaaacttt gaccacatgt tacaactaat gaatttattg acaaataatt 44400
atagcataca tggaatggtt gcgacttatg caaggtcgat atgttttgta tacaagggtg 44460
tttatcttca tcaaaataat aacagtacaa agaaaattat tctattctta gctagtattg 44520
atgaaggaga caagataggg ttttgtttac tctctacagt cgatgaagaa tgcgatgatg 44580
cgaaagtatc ttaagatgaa gaagatcatg accggtgttg tagtgactga ggtcaatcag 44640
catgcacttg gtaaccagtt tgtgaagaag aatgacgtca ttctcgagat tgatggtatg 44700
accgtagaag atgatggcaa agttttctat gaaaacaggt tgtggatgca cttaaatggt 44760
ttcattgctt tgaacatgtg aatattcggt cccttaatcc tttgatagcc tctacaaaat 44820
tttgatcttt atagtcaagg taaaccaaca acgttgattg tgaaattcaa gtggtaaaac 44880
cgttaaaaac aacatcgaga ccttgattta gattataacc attcatggga aacattttgg 44940
gtttaagtga catgaaaaaa gattgcttta gactatgtgt tactttgtta tgatttttgg 45000
aagttttaaa tatccactaa aatctattaa atgagaactt atttcacaat taaatgataa 45060
tatttaatat taaggtctga ttagagaatg tgaaagagtt gagttgacgc gattaagaaa 45120
attcggtgtt gtattcttaa ccctgcagag aaacatgaga ttataacact gcaatgcaac 45180
aaaatataca atgcctttac tcaattagta aaaacccaaa cgaaataaat ctttatttct 45240
attttttgcc tgcttttttc ctttttttct cttttttttt tgatgaatga atagagagag 45300
ttacacgaaa aaaaaagatt acaaagaaac agtccatgga aatcgagaga ctgttgataa 45360
tgaacattac atttacaagc atttacagaa acagatgata aaagaaattg attttaaatg 45420
ttattttttc agggtattaa agatcatcag tgagtaaaag ttgcagcaaa cgggattagt 45480
atgtgacccc ttctccatta gagctttctt tggccatagt ttaactaaac tcaacctgta 45540
acacatccaa aaatgttgat gatatattga gataataccg ttagaagagg attcaaatca 45600
tcgaaaaaaa ttacaggcta tgggatgtat tcttcttacc ttcttcggag aaagcgaaaa 45660
caccaccaag catgtcatcg tcctcatcat catcgagttt tccatcagat ggagcatcct 45720
tatgctcagt ttctgtaaca gtttcattgg agaccacctc ctcgaaaaac tgctcgaagt 45780
ttggggagcc gtcaatgggt ccttcaccct cgtctgctgc attcatgctc atatcagaac 45840
ggttagaact tacatttgaa tctccactta tcccactgct gttttcaatt tttgtttcag 45900
cgggcaggga ggcgttcttt ggcaagacat gagcgtcgtc gtctatataa tcagtgtctt 45960
tcacagcaga agaaatggaa actacaggct gtttaaatgt tacaattccg gtatgaggat 46020
tttggtttgg agttagtgca aaatgggcac tccctcttct ttcctcatct tcggggtaaa 46080
ccatacctgc taaaacttca gttttaagat ttgacatatc ttataatgca tggattaaga 46140
aagtaaattt gattaccatt gaatggatgc atttctttaa cttgtccagg gtcagaagaa 46200
gaagaagaat ctgaatctct ttccccagaa aatcctctac aagcaaagaa gaaccacttc 46260
aaaattggat caatgacaga cgcagtttat aagatgtgat gcagttagcg aggtaactta 46320
cctgttgcgc atactggtat acacactgtg aaaattatca tataccggca gaagatcctt 46380
tcgcctaatg tcaacctcgt tcgcagatac tttcccgatt tctgtctccc caccaccttg 46440
atgcgaattc aggttcttgc catcagagtc tggtggatac atcggataga aagatatctg 46500
gaattgataa aatttaaggg agtgtcagcc attgtacatt ctatatagta agaagacatg 46560
accagcagag acgtagatgg cacctctgaa ttttgccaga ttggttttct tccggagttt 46620
atcagcacct ctgcattggc aagataaaca tggtgtttct ccagaggctt tgtttgatct 46680
tcactatcag aagtatcaac agttaactca gcattttttc gtccaccata agtaagcccg 46740
catatgttct cctccctctc tggccaatcc gctcttcgac agacatccca acactgaact 46800
ggttcaactt tcactctcag ttcctcttca gaggtcagcc cagaagttgc tccatttcgc 46860
gtattgctct cagcctggtc tcctccaaga gatggaatga gtttgtattg aactacatga 46920
cctgatggag tgtaaaccag taagtagtcc aaggcaggag atgacgactg cgattcttgt 46980
ggcacagatt gatggaaaac agcagcaaga cagccagagg ggaaggtggg ttttcctaca 47040
acggaacttg cagcatggaa gaaattgttg catttgattc ggctaaccac agaaagagta 47100
actgacgctg gtggtggata tgaaaaatgg gtggtcataa acgacggact tgaccaccat 47160
ggcagggata atgttggagc aagcgtcggt ccatcgaatt gagagtttcg tatttcaaga 47220
acattttctc ccccgaacgg ggataaaaca taaatatggc aggtgctctt agatgaaaca 47280
attgcaatcc actgactgta gctactaaag caaatatctt gtatcacctg tgggaatata 47340
gcacaacagc gtttacagta acataaccat ccaaatgaac tatagctaca agagaaaaag 47400
gaataagaaa catacagctg atgtcatgcc acgatgtagt ttgtaaagag gcacatggga 47460
agagctccaa tcatagcttt gagcacccgg tccattcttt gtaggtgtcg gcataatccg 47520
gaaaacgtta atattgttac cgtggattga ggctgttact agtaaagtgc cactagggtc 47580
gaaacagaga gcagagattg gactagtgtg agccctgaat tgtgctataa tagctcggga 47640
ctcaaaatct ttgacaatta cctgccacag gtcatattga taagcatgtt atactccttg 47700
tgttaagata tccaaagtgc agaacaaaat aaagacaaaa cgttataaaa catttactat 47760
cctaatctag gttctcaata ctccataaat ggtttggcat atgtttaaca ttccacaacg 47820
cataccattc tcaagcaacc gaacaaaaaa acgagggttt aatataatca agataagatg 47880
ctttctctaa aagactaacc gttccaacaa catctgactc agctgaatga gaaccgaccc 47940
gaccaacttt ccggccaggg ctggacgaaa gagaaggacc aggaccgtca tgcttgagat 48000
cttgacagta tttagatata gttttgtaac ccttgtcacc caaattgagt aacccagctg 48060
ccaaatgctt actagattcc atagcgtatc ttgccaccag attaccatta tttggcgagg 48120
tagatggact gacaccagga ggagtaacat tctgagggct cagacgacct atactagaag 48180
acaagggact attggaagca tacgctaacc atctagcccc gacagccatt ggaccatatc 48240
caacattaac cccagatatc ccttggtttc caagctgagg tacaggatac gagaggacac 48300
tgaatttgtt ttcaagagtt agcgcatcaa aacaatatat ctgcatcaca atggaaaagc 48360
attaacagac agtagaaaac ttgcactcca tatcgaagag atagataagc acataaaaag 48420
ctaacctgcg aaccgaggcc aacagcgaca atccgaggac tgcatctaac catataaaca 48480
gtagatctaa acctcaaaac atgaacatag ttatgcgatc taagcgaata aaatcgcaca 48540
accgtgggag agagtgcaag aggatcctca taaccatttc taacagatcc atctctacta 48600
gtaacaatag gacctgaacc tttagcttca tcagcaacag ctaaaagtat aggatgtgat 48660
gatctaaacc cttcaactcc atcacattta gcaggtaatg gctgcatctg taaaaatgta 48720
accggatcat cccgcctcga cacgaattcg gtaacatcat ttgaatcatc gatatcaaga 48780
acttgaaacc cgtttgtata acctagtaat agaacgttct tgaaagatga ttcacttgtg 48840
tgcaatctat caaatgaaga ccacaacacc tgcttcacca aacacaagga tcacaacaag 48900
tcaaacctat ctcgataaaa aagactcaca ctttttccta atctgatcaa aatcacataa 48960
acccaattgg aaaatgaatc aaaaaccccc aaattccaaa atagagaatc acgaattggg 49020
gaaaatcaaa attgaggtca aaacctgatc tttaagctcg tgagaatcag aagagaggga 49080
agcagcgacg gaggcgctag ctgagcgaac accggaggaa gcagttctga tgcaagtaga 49140
gatgaatttt aacgaattgg gcaaaaagcc attagtacca ttattcttcg tttgattatg 49200
attatctccg ttgttgttga tgttgacctt ggagttactc ttcatagtaa ttatgaattc 49260
ttcgtggaag ataccaccgg agatacaccg gagaagagac aacgatcgga aacagcataa 49320
gccggcggcg atttcgaaga agaagaataa gtaaagagat tgtttaattt gagaaatttt 49380
gaagctttgc cattttttgg taattggggt taagcggtgg tgtgtttttt gaccttcttc 49440
acggaagaag aagaagaagc gaagaagatg atgatgatga tggagaagaa acggttcttt 49500
gctttttttt ggtttctgtt tttttttttt ttttgggttt gctttttgtt ttgttctttg 49560
ggcctttgtg gctttaagtt ttagttagtt ttgttttgtc tatttggttt ttgagtaaaa 49620
cttaaaagtc actgtcctaa aagaaagagt tactgtagtg ctttggcgtc tacgggtgtt 49680
ttagattgct gtgtaagcaa acaatttttt gtatttttta tctcgtgcat gttcacatta 49740
ttaccttttt ttttgggaat gtttaaatat tatcattcaa aaattacacc aaattgatta 49800
attgaatcaa caatagatct atttattgtt taagaaatgt agagatcgtg caagcttaat 49860
gttccatata atataggtcc tagggctagt tgttacttat ttggtgtata attgaaatag 49920
gttttagttt gcacgtcaca actcaaagaa aatcaaggca tccctcaggc ctaagccttc 49980
catgtttaga cccatttgca ccaaagcagt taatgcccaa cgactagtga tttgggtaat 50040
caattgcttt gtatgttgaa tcatatcttt cttttttagg ttagattttt ttttttctta 50100
gtcaacatga ataatcagat tatataccct aaatttttta gaaattgcta cactataatt 50160
tcattcaccc tctttattct agctaatcag aagctatccc ctaattttta aaaaatatat 50220
ttaattatta ttgaatttgc tgttcaccat ttaaaaaaat gtactccctc tagtcaatgt 50280
gttctcaact atattacatg cattaataaa gacttaaaga gtgactaatt cgaaatcttg 50340
tcagattatt gaagtaagag ttttattacg tcgttgttag tatacagatt atataacaaa 50400
caataaaatg tggttcccgt gtaaagataa ttataagtta taaccttata ttagacgaca 50460
aaaaaaaaaa tgttataacc ttatattatt tgagaagtta caaaaaaaga ttaaataaat 50520
atggacgaac aagagaaact atatctgtat atagtactta agttataacc ctataactca 50580
cacattcttt cagtagcaat gagtttaatc aaaatgattc cttagacttg tatttatcca 50640
ctcacacggt ttagtaatat attaaatgaa aaaaagctct aaaaggaagt tgctcctata 50700
tatcttattc ttcttttata tggttttaca aattcataaa attcaccaaa atgacagtac 50760
catgcatata ccaaccaccc tacgatcaaa cagcaaggct aaaacataac tgtaagtgtt 50820
ttcactattt tgtttcatgt tttcaccctc ttggttacga aggcaactat gccaaaactt 50880
attagtaaac tttgattaac tgacttttgt tgagaccaaa gaacagttcc aaatcttgcg 50940
tctacccgtc tccaattatt taaagaatat tttgtcagag ttgcacgttt ttacgaacac 51000
catttcatta atataactat atgttctttt aaaataaagg ccaataattt caccaaaaaa 51060
cttaaaaata aaagccaact actgtttttt tgtcctacac tcctacttga tttgtttttc 51120
gtcctttgtt aattacccac gatatcttca agccttttta aaaaaaaagt gtctaaaact 51180
tctcaagatc ctatataaat gtatgaagag ttttgaactt agtacttgtc acaaatataa 51240
gtgacaatat cctcttaagt ctcttactct atctctctct ttaactgtat cttaaacaaa 51300
aagaaagagt atgatcatca gaagaaaaaa gaaacaacaa caatggagag acaaaagagc 51360
atggaagcca gtttactcag gaagagtctc agcataagag aaaggaaaca cccaaatgaa 51420
gatggttacc ctgaatccag tttactcaga aagtgttcaa gcattttatt taacaccttc 51480
taggcgtgaa atgaaagatc taaatcaaca ggggtcaact taactagcat tgagctcttc 51540
tctaagtgat gagactatgc aactatatat catgaatcaa acattaaaca ccctaatcta 51600
gcctaacgat cacctatgaa tgagactact caattattat gacaattaaa atacaaaatg 51660
taagaaaact aaagattatc aataaattct aaaacaattg aataaatgtt agtgatgtta 51720
gcccaaaaga gtttagatct aagaggctac tgaaagtaag agcaagacgg ctactttagg 51780
taatgttttg agtgaacttt gctttgtatt atttcactta atctttaggt tacaacatgg 51840
ttccctttta tagctaaaca atgctagggt ttcaatgatt gtaaactgac agctgtctct 51900
gtcttatcaa gcttcggagg tcaccaaaca accaaatctg ttctttgtgt tgattggatc 51960
cgtacagacg ctcctcttct ctgtcttcac tctgatttgt tttcttgcac aggtggtggt 52020
cttgtctgtt gagaagagga agaacacttg ttgggcttcg ttgttgtgtt ggttgtgttg 52080
tcattgggcc tgtttggtga gtggcccaat aaccattttc ctttgttaag ctgagcgacg 52140
tcgttttctt tctttgactc tttagctgaa cttgagctct gcttcgatct catttcagat 52200
cttggagctg ttgatggcgg agcagtggag ctcttgctaa tagctactac aactaaccat 52260
aagtgaaaac tatatatgaa aagcttagga ttttagttct tatatgatag tatttatatg 52320
aaaatataag tgtatccgga tcgaccgatt cagattgggc aaacccttaa aggagaagta 52380
gataaatgat tgatcgtctg gtcgattacc attataaatc tcatgaaata cgtatgtctt 52440
tcctcttttt cgttgaagga ctaacttttt tcaagagaga tttacccgtt cgattgctac 52500
tggtcttagt ttcttcttac tcgaactcgt tattctcttc ttggttcttt gcttgttccc 52560
atctatagag tgtgtgcttc agatagtttc atagacctat taaaagataa tatatatttg 52620
caatgcatat gctctaggat cttaaattca aatcaaaact aaaaatacaa aaaaagaaaa 52680
gaaaaaacaa aaaaaagaag acataaacct agttgtttaa accactaaaa tacaaacgca 52740
taaacttact acacatgaaa atgaaacgac tacatacgac tgactacttt gcatatatat 52800
atttgtgaat tactcttcac tttttctcta tatataataa caacttgaag acaaagacaa 52860
aataataaaa taaccttatc tcttctctat atattagttc ttgagatctc tccaacaact 52920
ctactttgtc tttactcaag tatttcacta agaaagatag aatcacaaaa aggaaagaga 52980
aaatgagagg agaaatcgat gaagctaatc ttgctcctga aacttcactt attaacaaag 53040
agaatcaaga ctcatcggcg acaataacaa ctactctctt gctcaccact tttgtagccg 53100
tgtctggttc ctttgtcttt ggctcagctg tgagtttaca attactaatt tttgcttttg 53160
ttcagtaatt gtgtgttgtg ttttgtgttt gaatcttaat ttctaatttc gttgaaaatt 53220
ttggcagata ggatattcat cacctgttca gtcggattta accaaggagt tgaatctctc 53280
tgtggcagag gtaaactgtt attttatttt tttgtctttt aatttattat gccatatgtt 53340
tttgtttgct agctagatag gtaaaatata cttaagtaca tttaacttat gtgtatagta 53400
ttagttactg atctaatcaa tgagtatgga ttgaggcagt agtttttttt ttttttttta 53460
attgaggcaa gtagttgtga aagggttatg atactagaag aaaataatga gtggagaatt 53520
aaaatttaaa ggattatctc actatttttg tactaataat gagtggagaa ttgacggaaa 53580
aaaaaatgag tggagaattg aatttttgta ctgtagacgt actggtccta ctccaaatgc 53640
ttgcatgttg agataaatta gttgtgtccg gctattaatt atgatctcta tttcggttag 53700
aatttttttt cttttttttt ctccgtcttg atttaaggtt tataggtgtg gaaaaaatat 53760
catttagtag aaaattaaga aataagcata cctttacgaa agatgacaaa ttatataaac 53820
atcatcgtaa aaatcaagat atatcaccta taaatgtttt taaactacat gcagtactcg 53880
ctcttcggtt cgattctgac aattggagca atgatcggcg cagctatgag tggacgaatc 53940
gccgatatga taggcagacg agctgtaaaa tttgttcttc tttctttcca tgacaagcga 54000
atatttacat ttttgcgtca aactggtaaa taaatcattt atttgtgtgt gtgtgtgtga 54060
ttagactatg ggtttctcgg agatgttttg cattctcggc tggttagcaa tctacctttc 54120
taaggttagc ttagtatttt tctatatatc tctctgtatt tctcatcaac tatatttctt 54180
caagaagtac ttaaaattta ccatgtggtt tttgtctatt aaggttgcaa tttggcttga 54240
cgttgggaga ttcttggttg gttatggaat gggcgttttt tcgtttgtgg taaaatctat 54300
aaactctagc tagtagcttg aataatgaaa aatattgtgg tgattacaag aaaacaaatt 54360
cgatgatcaa ttgtaagatg agtgacctaa tgatctaaat aaatatatct ctacttttct 54420
tatatatcta tttacaataa acattagcct tctacaattg ttaatttctt aaaacgaaag 54480
ctatattggt catattagat actagattat atgttgaaac tatttgttgc ccccaagagt 54540
atgatatttc atatgtacta ctagctggta ttccggctta aaattgcgca tgcgaggaac 54600
aacacaatga aaagataact tcttcgattt atgtagctga aagttgttgc tagctatagt 54660
acagtagatt ttgtatcgtt ctttcatcta gattgttttg ttaatcgatg atcaggttcc 54720
tgtatacata gctgaaatca ctcctaaggg tcttcgtggt gggtttacaa ctgttcatca 54780
ggtatgaata tgttatacaa taactaaatt agtttttatg aatatgttat acaagaacta 54840
aattagtttt taaaaattaa atcagaagtt acaaaatata tactctaaaa gtattatttt 54900
catctccatc gatctttaac agtgttaaca ttgcagttac tgatatgttt gggtgtctca 54960
gtcacatatc tcttgggctc ttttataggc tggcgaattt tagctttgat cggtaatatc 55020
cgtcaacata ctttaaataa gttactcata ctaaaaaatt gttaattaat ttttttttta 55080
tgctccagga atgataccat gtgttgtaca aatgatggga ttatttgtca tcccagagtc 55140
tcctagatgg ttggtacgtt atccgtcaac atactacaag tttaatagtt tttatgtacc 55200
taatgccaaa tctagtctat ccaatcatta cgctaagtaa cccaaaactt tcattgttat 55260
agaaaataat tgttcgcaaa aattctcagg caaaagttgg caaatgggaa gaatttgaga 55320
ttgcattgca acgattacgt ggtgaatccg cagatatttc atatgagtct aatgagatca 55380
aagtaaagta acactaaatt ctatttcttg agctcactac attttttaca aatttccatt 55440
aaagtgtaaa atctcctgta tttctatatt ttctaggatt atacgcgaag acttacagat 55500
ttatcagaag gtagtatagt agatctgttc cagccacagt atgctaaatc tctagttgta 55560
agtgttttta acttataaaa ttgttcaata agtagttatt ttcattattc tatgatgaaa 55620
tgccaagtgg gttttaggtg ggagttggtc tgatggtttt gcaacaattt ggaggggtta 55680
atggaattgc tttttacgct agctctattt tcgaatctgc tggtacatgc acctttaata 55740
ttgattaatg tgcctaaacc ccaaaaatta aaaaagaact tcactaacca acttaatttt 55800
ttgttttgta ggggtttctt ccaaaattgg aatgattgcg atggtggtcg tacaggtaag 55860
tttttgggta ttattatttt attttcccca attttttgat ggttaattaa gtgaatgaat 55920
atatatttat atagggtaac aacacaacta atacaaatat atattacaaa aataatataa 55980
ttatactaaa ggatttttag ggaagaaaaa cctgagaaag aaagagaata tataatgtta 56040
gagtgtgaat tgtttccatt cgaaagagaa ggaagagagc aggatagcga tcagtcgcga 56100
cgactaattc ctggagattg ttgatcgatg cgataggtcg ctggatctgt cgctaaattt 56160
aacgactacc aaacgaccat cactggcgac tactaaacga tcatgaccat aaaattataa 56220
aatgaacaca cgcttctccg atacaaacca aatcgttcta atctgagttt catttgttta 56280
cctatcaaat acaaaaatta atctgaccca aaatttatcc tataacaaga ttatagagag 56340
ataaacccgt agaggaacca tatatcaagg taacatgtta gaaataccta acattaaaga 56400
aatgagacgt tgagtgatat atgaataata tggtctaatc cacttttgtt ttgaattgaa 56460
aagccaaaat aattacaatt aatatataat tgtttaacat ttaaaattca atgtatcatt 56520
tcttaaaatt atttgtagct gagacgaatt ttctttccag atccctatga caactttagg 56580
tgtactgttg atggataaat caggaagacg accattactt ctagtaagaa aaaacaagtg 56640
actaacattt ttttataatg ttattagtca aatacaaagt aatttttaca agtacctttt 56700
ctcactatat taaaaataaa gtttttaaag aatttatgtt ataactgtag ttccaactta 56760
ttattgtttt tttatctttt attattatta ttatacattg gtggataatt atatattgcc 56820
tccctagtcc ctatatatat gtcaatatgt atatgttgaa agaattacat ataatgaatt 56880
taatatttta tctcttcaga tttctgctac tggaacatgt atcgggtgtt tcctcgtcgg 56940
tttatcattt tcattacagg ttctctcctt atttatattt taaaataata tcttgatttt 57000
atctattttt aacatattat gttttagtat attaatatca gtataaaaat tgaatatttt 57060
ttgtctacag tggtgccata tgactttatt gttaccataa ttataatttt ttcttctaat 57120
agagatttaa tatattttct cgatctatgt ctagatctag atgataaata tctagaaata 57180
ttaattttta ttgtttgatt gtatattaat attaaaactt ctcaagtagt tgcatatatg 57240
cttcaaaatg tttataattt catattatgt actataattt ttgggttcat cctgttgtag 57300
tttgtaaagc aattgagtgg agatgcttca tatctagcac ttacaggcgt tttggtaagt 57360
ttgacgacta aaatctagat ttcctttttt tttatcctca atttgaaaag tttgaaaata 57420
gttgatatga atatgatagt tttggcatac tgaaacgttg ctgtttgaaa gtgggaatga 57480
ctgtaccaat aagatggtgc atgaaaaaaa tagaagaact gatatacaca tctatatcat 57540
caaaatacgt ttatttttcc tgtaactcgt tctgaaagaa ctatatagta gacgtgtttg 57600
agttgaagga attttacgat gaatgacttg ctaaaacaaa tttccgaata ctatgtcggt 57660
gaggaaaaac tactagaaaa gaacaaataa tatcattatt gttattaaca agtatttcgt 57720
ggcttctggg atagcgaacc aactattgga tgaaattaga acccacacac atactttgaa 57780
agatcgtaga cgtccataaa tgataaattt atcttatttt ttcaggtgta caccggatca 57840
ttttcattag ggatgggtgg gattccttgg gtcattatgt cagaggtaag taacattcat 57900
aaaaattctt tggttttaaa catactctta tacttaataa tccgatcgat gtcttaagaa 57960
atattaaact ttatatcata aacctacggt ttagtattaa aattaaataa taaattattt 58020
aactctcata tggttgtatg tggtatgatt ttgatcagtg tatataaatt atgttccttt 58080
atgatttatt tattgattct ttgtttatat aacattttaa ttcaatttag ttggtgcgta 58140
gatattaatt ttatgtttta tatgataaag atatttccaa tagacataaa aggatcagcc 58200
ggaagcctcg tgactgttgt tagctgggtc ggatcatgga ttatatcttt tacatttaac 58260
tttctaatga attggaatcc ggcaggtata aaatttgttt aaattttgct tttatcaata 58320
aattttgttc tttatctaat agtggcacaa gttttaaatt ttcaggaacg ttttatgttt 58380
tcgctactgt ttgtggggct actgttattt ttgtagcaaa actcgtacca gaaaccaaag 58440
gtcgcacact tgaggaaatc caatattcga ttggttatgt agaattgtaa tgtatagtag 58500
ttgattacga gaatatcagt ccctaattat aacgattaaa agtaagattt tttatttttc 58560
ttctttcctt ttggtataat cgtatcatcc tttttgctta gtgaatttga ataaatggtg 58620
ttgtttttgg ttaccaaata tcggagaaca taattgaagg tgtcgaggaa aaaaatcgag 58680
gttatgacga gtttacaact tctaaagaca gtgaaagata ttcgaagttt ttttggacat 58740
atatgttggg ttctacaaaa aaattataaa atatttcttt gagatagtta gaccgcttac 58800
aaaaatgtta tgtatggagg tcaattttga tttcatggat gagtgcaaaa aatcaatttt 58860
aaaaaatgat tgtttgacaa atatccattc aaaatatact aactaaggga ttagatcacg 58920
atattaatga catattcttg ttttccattt tttcctttaa cacacacaaa ccaaaaaaaa 58980
aattaaaaaa aaattttaaa aaaatagtca tttttcctct ttttatatct aaaaacaaga 59040
aagaaaacca attaaaaaga agtgacagag attgaagtgt gaagccatct gacgtgggac 59100
ttatcttacg ttctcttcta atctctacag gtcatctttc tcggtggcac ctttattcac 59160
caagcaaaac accgcttctt tcgatcatct atctctttcc cattttcttt tcttgacttt 59220
tttttctctc tcttcttgtt ctattataaa caaaaaatgt gtaataatta ttcatcaatc 59280
ctcagaataa tacaaatagg ggagtaggta tctatcttgt caccctctct ctctctctct 59340
tgttaccaag atgagcttct acaaaagaag ctttcactct ttccttggcc aaaccaacac 59400
caaagggatg ccgtttgaat ccggtcttgg ccatgatgag acacaatcac atggcttaat 59460
gttgtgcaca gagtatctag ggtttgagag ttacgacatg aggatgtccg ataacgaggt 59520
ggagaacaag atgacttgtc atgcggaggt ggagaccgaa agggttgaag caaagaggag 59580
gaagacgaag gagaatgtgg tggtgcaagc gcagaaaaaa cagtttcctc cgcctctctc 59640
gtcattaaac agccgtggac agcgatattt ttatctccgt ccggtgagaa aagacggtag 59700
attggaactt acgcaagtta tggtcgatcg accagagatt ttccacgttt ctagagtaga 59760
tggacggttg agattacatt ttgtcgatgg tgtcgagaat cccattagag cttattctgg 59820
tcctcaagaa attgtggcct tagaagagga acctaagggt ctaggtaatg agaaagaggg 59880
aggggagatt agtagatctg atctggaatg tggtagagag attaatgaag acgacaatga 59940
tggtgcatgt aatcaaggaa tggatttatc tataatcagt gatgatagtg gtgcaagaag 60000
ttggagatgt aaaagtagtc atgatgtttc ggtgaatagt aataatgatg ttgcacattt 60060
ccatgatgac catgacacga gagaatggat gtacaacagt ggttttaaga tcgtggcaag 60120
taggaaccat gatgagaaca atcatcatca ttatcatcat cgtcatcgtc atcatattca 60180
tccataccat catcataata gtaacaataa catgaattta tggacccgga cgtacgtgag 60240
gaccaggtga ggttattaat caatgttttt tttttttacg tggcggcttg aaacaaaaaa 60300
tatatcaact aaaaaagagt acagctatat tttctctgga agttccgttg tatttttata 60360
aaatattcga aaagtcaaag gttgggtgtt gttataagta gtgtcaacaa tatgatagcg 60420
tgtgagtgta atattattgt tcgtttaaga tgcttatgta tatgacttcc ataattgaaa 60480
catcttatta caactttcaa ttttcatatt attatgcctt tttaacaaag tattattcca 60540
attttgatta caccgttttt tatttatgta atttgatcaa aataaaatcg acagataatc 60600
tcttcaaaag tttagagttt agatgttcca gttttaaaaa taattatgat gaatccggaa 60660
taggccacaa tttttttttt ttaatacaag attttagagt aaaactcgta atcctctcag 60720
acacgaaacg acaacatgta atattagttt cgttccaaaa atatcgaact gacgattttt 60780
aagcttcggc taagagtttt actagttcag caatgatact tagtggaata ggccacaatt 60840
catatgttat aattcaatgt ttcatcattt aatgttttag aatcgaactt agtttggtgt 60900
tagttaaaat cttttcgacc ctcgtaatta agaaataagg aaaacatagg tgaaaagata 60960
gaaggcaatg taacgcaaac gagtctgtct gatcggtcca attgttggtc attcgtccat 61020
atatagctgt ctgttgaaaa ttggaacatt aatgttgtca aaattctaag attgcaggtt 61080
gcatttatag actccatttc cctccacaat cgacaggtca caggccttta cgccacatat 61140
aaccccaaga tacaatgcat atttaaaagt tcttgtgaac tgaagaaaag tttcgacggg 61200
ttgagatacg agacattgaa ttttggagaa gaaaacaaaa gctagggaaa aagtttgtgg 61260
tccgcaaaac attgaaatgc aataagaaaa ctgagttaaa aattagagta ggagccgtgt 61320
tgattcccta ggaaagcttc aagtatagga gattgcatga aacgttttga taacggaaat 61380
gttaagccta ataaaaggaa gtcacctcct tatggggagt ttattacggc ctatacatcg 61440
catgtagaaa acgagtttct cggttagaac ttaaaatgga tttggaagta gtggttggtt 61500
ttctgaagat aagggttagt gaaacttatc cgctgtcttt cctgttacgc ttgtgacatg 61560
gctttatatc aaaggattag aatatcaaaa tttcacatat ttaccgggag gataatcgtt 61620
ttgcggatga attagctaac catgcttttt ctttaaattt agtttttcac tttttagata 61680
ctattccaag atgttctctt ttgtcggatg atgcccgttg tttggcaatt cgatggcatg 61740
ttgttgcttg ttaagttttt gtatgttgct atgaataaat ttggggaggc attatctccc 61800
cgtcccctac caatttcttt ttttttcttc tatcccatat atatatatat atatatataa 61860
atttcgaaaa ctctttgctt tcattttctt aaaaaatcac gtaaacataa ttttagaaat 61920
aattaaataa caacttataa tatttttttt tcttcccata tatataaact ccgaaaacat 61980
atagtcgtat attatttctt aaaaaatact ttcaattgac tttttccttt tgtattaaaa 62040
tctattctcc cacatatttg gtagttattt aaaattgtag ttcatacaat cacagtcttt 62100
accaattaat ttaaaaatca tacagtcaaa ttccttacat caaaaatcct tataaccttt 62160
aactatgcga acaacaaaga ttaccaaact tccaaacatt gatctacaga ttgactaatt 62220
tttatgcaat ttaaattact accatttttc catctatata aacccaatct tgcacccaca 62280
aaaaaaaaaa aaaaaagaga aacacatact taatctaaat ttctcctttc tttatagtca 62340
attcatattt ttgttttctt ccaaaatgaa tcccaagaaa accaaaggaa agcaaatgat 62400
taacatcaaa aaaattgaaa aagatgaaga cagattggtc acattatcta agcgtcgaaa 62460
tggaatctac aataagcaat gagctttcca ttctctgtgg tgctgaagtt gcgtttctcg 62520
gatactcttg ctcaggaaaa ccatacacat tcggcagtcc gtcttttcaa gccgtggcag 62580
agcgatttct caatcgtgag gcctcatcat cgttgcaacg atcggtcatg aatgctcacc 62640
aacaagcgaa gattcaagag ctttgcaaag tatacaatag aatggtggag gaggcaaaga 62700
cggaagaagc caaagtaaag aaggcagctg cattagcgga gacaatgccc gtagatgagg 62760
atgcgtggtg gaaagtggat ccaaaggagg tggaagatca cgaagaggcg aagaagataa 62820
tggaaaagtg tgaagggctc tatgagaaac tgtgtaatga agctgctgca aggatccaaa 62880
gaggagatgc tgagaataat aacaaatgat ccattaatga ttaagatttt aattagtaga 62940
tcattactaa ttaagtattt ttgagtctta agaattatgt tttttttttt gtcttttctt 63000
ttttatacat tatgaattgt tattgttttc tacaacatcc agcaatggat taatgaaact 63060
gaaatatttt atacataaaa gaagcccatt acagccatta ggcccaattc gtgatctatc 63120
atctactcaa tctctaaccc taatatctcc aatcttcatc tccgtcgatc tccattgatc 63180
tctaacacta aaattctact actcttcact ttctacagct taggaagagt tctcgacaag 63240
ctgattcttc gagttctcga caagtttcag tgtttttgtt tccgggtcac agagaacaaa 63300
ggcaatttac aataatggca gagactaaac aaccactgat cggtcttaaa tgggaaccaa 63360
agcttccagg cttatcctta gacttgaaaa ctggttcaac cagaagcaaa acagctgaga 63420
gttctaagtc agagcttgtt gatggtcttt gtcttccacc taatgatcca aggaagatta 63480
acaagatgat tagaaaacaa ctcaaagaca ctactggttc taactggtaa ctcttcttta 63540
tctcctctac tcggattagt ttgatccggc ttgtgattaa attgtatttc ttcaaactgt 63600
ggataggttt gatatgcctg ctccaacaat gactcctgag ttgaaaagag atcttcagtt 63660
gcttaaggta atagattctt ttgcttttgt tgttgtttta ggttccatag tccttacatt 63720
attctaattg tatctttatt gtagttgaga actgtaatgg atcctgctct acactacaag 63780
aaatctgtgt cacggtctaa actagctgaa aaatatttcc aggcaagttt cagaactaga 63840
tcaaagagaa taaccgtctc tttcggtttc tgtcttaaca caaacttttg ttgtaaaaaa 63900
aaaaacagat tggtacagta attgaaccag ctgaagagtt ttatgggaga ttgacaaaga 63960
agaatagaaa agcaactctt gctgatgagt tggtttcaga tcctaaaact gctctctaca 64020
ggttagttac taccattgtc tattaagaaa caatgtatag gaaatgctta aattctgtaa 64080
gtattattga tagatgtaag taaaataagt gtgtggttta tctattctat caagaatttg 64140
tatttttgag aatttgtatt catatagcac atgtgcaatc tttgttaagt gaatgttttt 64200
gtgttgatta tggttttaca ggaagcgtaa agttagggag attgaggaga agagtagagc 64260
tgttacgaat aagaaatgga ataaaaaggg aaaccagtct aagaacacaa agccaagaag 64320
gaactgaatt atttttgtta agagtatgat catagttttg ggacacattt tttctatttt 64380
taatagaata tggtcatagt attggataca ctttcttgcg gtgatatagg ttgtaatgac 64440
tcttgttgtt tatggccttt gtttaaagga ttttgtgtta ttggttacac ctttgataac 64500
tgtaataact cttgttgttt atggtgctta tgttatgtat atccaaaacc aaaccttgtc 64560
tagagctact aggtgggaaa cttgtttcag caagactgaa attgagtcct agtttacacc 64620
ttttgcagaa ttgcagggtc caaccacgag agcatcgagt tttatacttt caggtagcac 64680
tcatagtacc tccctgtttg agtcatctgg cactgaccat gccacacata tttatgtcag 64740
cacagcaaaa ctttggtatt cagcaagatc taaattatgt gactttcttc ttttgaatca 64800
tagttgtaat gaggaggcta agagtattgc tgcagctgct tcgagcaggg gaaagattga 64860
ggtcagttgt ttgaattttt gttttcgctc ggcgttgttc tatgatatta tatcagctct 64920
ttggaattaa gaagatgaat tgtgtgtgta ggatttaaat ctatgtcaag ttgaactgtt 64980
taagcttgct tttttttttt ttttgaatct gtgtattggc tcggtgttgt tagaatctaa 65040
tttcttacta agtatctcga caaagtcagt ttcttggaga gtgctgatta caggcagttt 65100
gagaaagaga gagacgctag tttgagaaga cacgatgaga ccgactcctc taacgttctt 65160
ctacatctgc tgtaagtaat cttgttttct gttctgttag agaagtcttc tttagtagac 65220
tttgtagcat tttctcaagt gatttggtca cattctttgg cagtgtctaa accgagtccc 65280
cgttttcttg attgattcgg atttatttct tatgtctctc tcgagagaga gttcaaaact 65340
gagaccatcc tctctgaagg ccatggccaa tgaaatgggc ttgcaatgca acgtaagccc 65400
aacttgaatc ccacgattct aattcgagcc gatatctgaa acaacaattc atttgtgact 65460
gcaatctaca ccaatctaca ccttgttctt gtaaatcgtt tgttttctta gtttctacct 65520
aatgaagctc atttggtctc tatacaacat aaatttcttc ttttggtttt gaaatctaaa 65580
acctgaagta aagcttgatt gatttggttt atggattgca ggggaaaaag tggctctctc 65640
tttaacattt acaaaaaaaa aaaaaagtgg ctctctacag agttgatagt cgtaaacaag 65700
caagctcgtg ttaggttttt tctattgttg gatggttttg tatcaatgtt ctcaatattg 65760
ttttactaga taatgaagat aacttttata ttgtaaatat attaaattca ttttgtaatt 65820
attatttttt ggacaaatat aaatgcatat ataagtaaaa atgtgataac acgtttcatt 65880
gagtgtatat ttaaaatgta attatgcaaa aaaaaaatta aaaaatattt aattagcaat 65940
ttagaagttt aaacatcaat tctgttttga gaaaatagta tagtttatag acatgtagta 66000
tagctaatgt ttatttcaca catatgccaa tttttagtaa ataaatcgtg aagtgatcat 66060
caccataaaa tctgatggcc gcaattcaaa cccatgtaat cgaattttgt ttctaagata 66120
gaatctaaca caaaataaat tagtatacat acatgatata ttaatttttt ttttgtaaca 66180
tgatagatta attaatttaa agataagaaa ccacacacat aaattattta tagattttta 66240
aaagtttcaa tatttattac atagaaaccc aaaaaatcca tcataaaagc ggttatcagg 66300
aggcgtgtaa aatttcactt gagcaaattt gttttggttg cagagatttt tgcaagcaat 66360
tctcacaaaa aggaagagtt gccgttttag aatctttcat gcactgattt gggacacaat 66420
gtttaacaca tacttctatc gtactcgcgt atgttgaaac tatcatcgtt aataaaacta 66480
caatcatcaa aacactatat atctttttca ttgtttcagt tgccattatt tgaaaatatg 66540
agtttgtgaa tgtttgaggt aataaaaata ttgtttaggt tatatagcaa aaaaaaatta 66600
acaagataat tagtgttgag ttggcttttt gtagttttgt actttatata gcaaaagtat 66660
ttttatccac ttaaaattat tgattttgga agtatatccg tttcttatta attaaaaagt 66720
tagttttttt tttgtttatg ttattagctg tccaaacaat cttgcaatgt taaatcgtca 66780
tttaccaaaa aaattgccaa attttcacca ttgtcaataa taagtcaaat attttataat 66840
cttaattcaa aaactatccc ctaaaacatg attatataaa aaaaaaatcg tattgatggg 66900
tcgagatatt tagcattaac ttataaacca aaatgaattt acaggttgat ttgatctatt 66960
taaatttatt ggattcatag gttgacctaa ttaatttagc taaataattt atctaacact 67020
caactaatta agacaataga tggtacccat aatagattaa atttgagtaa cttcaaaagt 67080
ttctattcag ttttttttct tacaattttt ttgtggtatt aattctaaag cattatcaat 67140
aatattgtca catttttaaa aatcttattt cagaaattat cccctaaaaa agattataaa 67200
ctagaacctt ttttttgtat tgatgggtag agatatgtaa tcatttaact tacaaaccaa 67260
attgaattta catgttgatt tgatctattt aaatttgatg gattcatggg ttaacaacaa 67320
caagaaaaac aaaattagtt taatattata ccacatgtca cgctctagtg agaatgttaa 67380
gagtttatgt aataacacta acaaattttg tatatttttc ctatactata aacattttta 67440
attttttttt ttgaatatat taacaacaac aaaattaata gaatgaggtt aatagtttaa 67500
tatattagca ttttttatat aagaagtaaa ttttatttat ttttgaatat ttaacaaaaa 67560
caaagtttaa taaaattagt ttaacagttt aaaatagcaa taacaaaagt cgaacataaa 67620
aacaattttt tttcttactt aatatatata tttctttttt cgataggatt aagaactttt 67680
gtatttctat ttttaaaaat attaacaaaa ttaagtttaa catcttaagt tttaaaaatt 67740
tggcaaattt ttaaattaca tatattttta ttcttttgtt tttgaaaata gggagtaata 67800
gttaatgtag ttatagacta tagagatgca ttgtcaacaa taaaacgcca cgtcgcagca 67860
taattaaaat cttttgcaca aaaatgtggt tggccttagc cttggccctg gaattaaaac 67920
attatccaga aaatcttaca tttccaccaa tccttcactt cctttcacga tccaaaacaa 67980
aacacaagaa aatgcaacaa aatcttctcc atctctgaac tcaaaaactc attcactgag 68040
aaaaatggag acccttctct cccctcgtgc gctctctcct cctctcaatc ccaaaccttt 68100
gtcccttcac cagaccaaac ccacttcaca ttcattgtct ctctcaaaac ccaccacctt 68160
ctccggtcct aaacacctct ccacccggtt cactaaaccg gaatcaagaa actggttaat 68220
agatgcaaag caaggactag ctgctttagc tttatctcta actctcactt tctcacctgt 68280
tggcactgct ttagcctctg agttcaatat cctcaacgat ggtccaccta aagaaactta 68340
cgtagtcgat gacgctggtg ttcttagtcg agtgacgaag tcagatctta agaagctttt 68400
gtctgatctt gaatacagaa agaaactgag actcaatttc atcactgtcc gaaagctcac 68460
cgtgagtttt ttgttttctt atgaaattga ttgtttttgt ttaaccggaa attgatccgg 68520
aaccggtttg gtaaaatttg gcagagtaaa gcagatgcgt ttgagtatgc agaccaggtt 68580
ttggaaaaat ggtatccttc tattgaagaa ggtaacaata agggtattgt tgttttgata 68640
acaagtcaga aggaaggagc tattactggt ggtcctgctt ttattgaagc tgttggtgaa 68700
aacattcttg atgctaccgt ctccgaaaat cttcccggta tggttctatt actctagttt 68760
agtatatata tagtgtactt ttggaatttt gatgcatcat ctagtgccca agacaaaaac 68820
aaaactagag gtttggtttt gattaggatt tttcggttta taaacaatag taaccaaagt 68880
agaacctatt ctagtgtcca tcgtttggaa tggtttcggt tttggtttgg tttcggtcta 68940
attttcaagt agaattttgg gactggctgt ttctaatttc tctttgtttt tttttttttg 69000
tatatagaga aaatgaatcc attaaatttt aacattttct tttatatcca atctttattt 69060
tgcatactaa gttgaaaaca tattttttaa caaatttagt tttaactttt aagaaggagc 69120
atattgtacc aacataagtt ttcagctgta atgttagaaa tcaactatgt taagtttgag 69180
ttggtattga ttagtttttg aatgtatgat ggtgcagtac tagcaacgga cgaaaaatac 69240
aacgaggcgg tatatagcag tgcgaaaagg ttggttgcag ctatagacgg tcaaccagat 69300
cccgggggtc caaccgtaaa ggatagcaag agagaatcaa atttcaagac gaaagaagaa 69360
accgatgaga agcgaggaca gttcagtctt gtcgttggag gattacttgt aattgccttt 69420
gtagttccca tggcacaata ctttgcttat gtctccagga agtaagtaag taaactcggt 69480
tcactctcgt aaaccaaacc gatcaggtca gaactttgat ttacctcggt tatttggtta 69540
tggtttcttg gtaaattggt ttatttgaac aatataagta aataataaca gaaaactaaa 69600
gaatgaatga aaccatccga ttgtaacggc attgtttaaa atttcaaggt tagaaaaaat 69660
ggcatttgat ctgaaaacgg tggatcggaa tattttccgg ttaagatttg agatgagacg 69720
aactcgtttg cggcttcggt ataatgaatt ccatcccagt ttatgtactc ggaactatcg 69780
ttgcaagctt tggctgttac tgatatccca tctaagactt tagtttggcc acatgtaatg 69840
cgactatcgt aatttaatgg cgcccctccg actccacaac acgccattaa cggtttttcg 69900
aagcctaaaa cattcaaaat tttgttataa ccaacattct caagatggtt aagatcgata 69960
agtggtttag tgaaatgctt accaaatcgg gaataattag cgatgagatt agatttaata 70020
gagaagatgt caacgtaagt aacatttgca tcagggtatt gagcttgaaa tttgttggac 70080
atagcatgga gttgaagatt gaaaagctta gctgcttggt tatgggaact aacgcaacca 70140
aactcatcaa gttttgttga atctgtccca aacttggcaa tattttgagc taaacatcct 70200
aaaggccctg tgttgtgtat ccaaatgttt ctgcctcctt cctcataaag cctctgccaa 70260
agtaaatttc tcatttgcat gagaccactc cgatttatcc aaataaacgc ccttggcgaa 70320
aacaaaagcg agaaatattg atataccttg aggccagctt caaaagtttc aagaatggaa 70380
ggaatagagg caagaacttg gtcaagagtc ttggagtaga aggcaccagc tatatcattt 70440
tggcctatgt caatcatgta taatcctttt gaataataat caattggtgg taagtacttt 70500
tcatatttcc ttcctgaaaa atcatcaaac aaaccattgc ttcatttcta catcatataa 70560
cattatacgc aatcacatct caccaacaat tttttttaaa attagtccca cctgttttag 70620
aaagtaattc aatggcccta gatttgaacc ggatgaattg agagatttga agatcaaagg 70680
agaaaggaga gaccgaggtc gggtttgcgg gaagaattgt ggatcctgct gctgcaaagt 70740
tacacccttt tttgaaattt ggtaaaccta atgaatccaa atatggattt aaaaatggca 70800
ggtccatttc atccactgca caacacaaaa cacatatcaa aaacaatttc tttgaattga 70860
aggaaccatt tcaatgagag gaacaacatc agtttgtata tatacataga aaatctacaa 70920
taagacggcc gtcacaatat cttcctgaag gaaggttgaa gtaagtctgg ccatagggag 70980
gattaacatt ttcaatcccg gcagatatga gattgcccgt gtcggaattc gagtctccaa 71040
agttgatgat tgccggatat tttaggatta tggagaaaga tgagggcaag aacaaggaga 71100
ttaagatgaa gagaacaatg gagagattgt ttacaattgg agccattgag ttggaaacaa 71160
acaataaagc cactatgaga ttgtttatct actcgctaaa atgagtatca aactgaaaaa 71220
agcaaaatat aaagtgtcta caacaaccat gacaaacttt cattagtaat taatctaaaa 71280
actagtataa aacaagcaag cgaaaagaaa actgattacg tatcaaatgg agaccactct 71340
cagattgttt ttttggtcac taaaacaaac taaagaaaat aatatttaat ttataaatat 71400
atagtaaaaa tactattaga ctactattta atcaatataa ttagcttaat accacgtacc 71460
tagctattaa atagatttac tgtaattgta attctacaat tctaagaatt catttaatag 71520
aaacatacaa aaatatacaa acttagtaat cggattaata attattttct caattacaat 71580
cacatatttg taattgtttg cactattaaa accgcatttt gttatattta gaacatgaat 71640
ttttaattga acggagatat atcagactca gaaatgtatg aaataatgtt gcttcgagaa 71700
tgctccgagg ttgcttcgtg aggaatattt atcgagatta tttttttctt taaagggatg 71760
attagtttgg ttccgaacga agaaaacccg ttagtgtcct tgcgctttca attttaatga 71820
gagttatgat tttttttatt tttttttcat gttaatgttt tggggattgc aatttctatg 71880
ataaatatca tgtaattaac aaaaattaaa tatcaattca tgtagcaacg gacgaaaaat 71940
acaacgaggc ggtatatagc agtgcgaaaa ggttggttgc agctatagac ggtcaaccag 72000
atcccggggg tccaaccgta aaggattaag aattagatat tatctttaac tataaaaaat 72060
cgaattcaaa ataatctagg attgatatgt tctattctat ctagccttct atttttggtc 72120
ggctctattt agctttcaat atttagtaaa ctcaatatgt atctattgat tatataaaag 72180
agtgtgtttc aatagattgt agatgaataa aatagttagt gaacattatt agtgtaagaa 72240
gataatagaa attgaacaaa aaaaaactta cttagaaaat ctataacaag acgtccatcg 72300
cagaatcttt gggatgaagt tttgaaggaa ttttgtccgt taggaaggtc tagacgaatg 72360
ccaaggccag caacaagatc accggtatca gaattggaat ctccgaaatt aaaagcagac 72420
ggataattga aatcgatgga gtttgaaatc tgtaaagaac tgataaaaaa taggatcaca 72480
tagaagagtt tcatcttagt tatattcatg aactctcgct atgttgttta aatttgcttt 72540
tgagatttat aatttctgtt tttcgatgtc tttttaaatg tggtgatgct ttaaattgtg 72600
gaaagaggaa aacactatac aagcaagatt gttgctttga atctcgcttg caagtcttac 72660
tatctctgtg tatttttata tgatgactca cataaacaca tttgatactt aaaatggttt 72720
ttccaccctt atattaacct ttgatgattt gcccgagtga gattttcttt cttgataaat 72780
gtacatatgc aacatcttga aagcatagga aacgacaacg tctatcgtcc gctaaggtta 72840
tttgctctat tattaaggct attaattatg gactttagga ggggactgaa agaatatcgc 72900
ttatgatttc catgtgattg gggtgtggaa caggaagaga aataaaagaa aaagtggaaa 72960
tttgaaagag aagtgaacat tagggaaata aaaagaatca tggctcaaag tttataagtg 73020
tagaaagaaa aaaagtgttt atgtgtttat caccgagaat tctctcaatc ttttttttgt 73080
gaatcagatt tttctcacct tttttttttg tttttttctt ttctttctgt ctgatgaaga 73140
gaaaagagtt aaatatatag agtccaacgg ttccggcgta catttgcaac attacattta 73200
ataaattaac cataatctca atagttgcaa tggttagaga gtaaccgctt ataacactta 73260
aatctccaac atgttttgct tgcagtttgt ggcactaatt gttataagag ttagctctct 73320
cagtagcacc aaactggtaa gtgagtttct gatacaagtg ttgttatata aaaatccaat 73380
gtgattgatc gttggggatg atttaacaaa gagaatgatc agttctgaga agagcattta 73440
aactttccgt taagtggagt gatgaagatg atttattggt gtaaagacaa atgttacgtt 73500
gctatctatt ttggggaata atgtaacttt ttttaccgtg ctatctttac tatgtagacg 73560
tatataattt ctgtcaaaca tcttacttcg attttccata actctgttgt tacactttca 73620
agagatcatc tataactctt tcaagagatc taccaagtta ttcaaaggta ggaaatgcct 73680
acaatgtgaa acttaaaaat ttaacatatt ccctcttatt tagaggtcta gttttgattt 73740
tcatgtgagg agaacgattt agtgtataat ggttttaact tactctgtgt tagttaacac 73800
atatttatga gtaaattaaa tatcaaatgt tggaagttgc taagcatatt ggcctcattt 73860
actttgctag aaagttaata ctctacatgt tttcactata aacccttatc atcatgcata 73920
ttgctgacaa tgttatttta gtttttatga aattaaaata atatgtgaaa tagtgaattc 73980
tgtcaactaa aaattatttc agtcaaaaaa taaaaattat aaataaaaat taattcgaaa 74040
aacaaatatg agcatattat taatgtaatt tttagcctaa atggcaaatt tttccctaca 74100
caaattagct cattattttt cttaacatta aaattatttg tctaaaacct gcattcttct 74160
aatagagtga aacggttttg ggtttaagac atgtgagatt gaacaaacaa gacgttgact 74220
tgtgagtaga aggaacatgt gaacttatat ggaccatgtg accttcaact acaatcattg 74280
gaatgttaaa ctactgtctt ctcttatttg gcatctaaat tttgttttta ttactctcta 74340
aacaaaaacg aattaacaag atttctgcac aaaaatgtat gcattttgtt ttacgtacaa 74400
tcatctaatt cgaaacatat ggggtgaaat tttttacttt ttaaagacaa caaaccaatc 74460
aatcacacgt gaatattgcc agaagagata tacacttgga gaggataatg aaccattagg 74520
tgtccccaag tactaaacta gacctctacg gtgccaaaga aaggttccgg agttatgagt 74580
ggtcacctct cctacctctt tgaaagacat gtatatcgct ttaactcctt aattattgat 74640
tcttgtgtgt aagggcaggc aacctatgca aatagacaaa ttcatatttt tcatcgtgat 74700
catagtaaat actacaattt tttttttttt tttttttttg gtaaaatatt acaaatttag 74760
caaaagacat gcaaagatta aagacgctat gataagaaag aaaactaatc ggatatataa 74820
ctaaaaagac gttgaaaatg gcaaatatca atcatcaatc caaataatat tcatatacct 74880
ttcatctatg aactaaggtt ttttaactaa tatatatata tatataccgt atgattacac 74940
tgtcaaacta aagtataaaa tgcaacaata gaaaatatga gaaataaaat aaaatatatt 75000
aattatttgc ttttcaacta ctttaatatc ttaatttacc atgagaaaga aatgaaaata 75060
tgagtcgaaa taaaaaaaga aaagaataag tagtttgaga acaatttttt aaaaaagggt 75120
aaaagactag aacatatagt caattgatca tctacacatg ttgttgttag aagaaaaaaa 75180
ccaaaagacc aaaaatccaa aaaggaattt ctcttcacat tatgtgtatg gccataaata 75240
aaaacttatc tatctatctc gcgggaggaa aacaaactgc tcgtgttggt gcttttgtaa 75300
ttcgtctttt cttatgtatt atctttaaga aaagtctttt gcattgtgca cctacacaac 75360
attccgtttt actaaaagtt aatataccaa attgcaaata attcagctcc agtttactct 75420
tgtttattta gtttgatttt gggtgcattt gatatctttt tcatcgaact tatgtaaatt 75480
ttctctaata atcgtaaact ttttctaata atcgtaaatt tattatcgtc aaatattcca 75540
atttgttatt gaaatgtttt cgtaatatac ctcaatttca aatttaaata ttttatttta 75600
attttaaaat tgcgtaaccg taattttaat tttaaacttg ctcaccctaa gatgggtttt 75660
attttctccc gaatttaata tttaatttac taaaaatgat atgataagcc tttatgtatg 75720
taaacttttt ttcttaccat tttttttaat acttccattg ctcttttttt ctgacgtctt 75780
ctttaattta ttctactcta tacatatctg ccatatatgt gtatatagag agaaatatac 75840
ttcaattcgt ttccaaacct atactctcct ctctcacaaa aatgaacaac accaaaatgg 75900
aaaacaaaag ccatagcaac caccaccggt accatcatct atcatcccgg agccacgagc 75960
aaaaccagcg tggcctaatt tcgataaatg ccataatcat cattggcatc tccattatct 76020
ccatattcat aatccttgca attctcctaa taatcatttt acttcatcga cttaaatccg 76080
caagagtcaa agcacaagaa ttatcttgca aagaaagctt caacaacatg aacaatggtg 76140
gagcttccac caactacagc tacacttcta gccctggtaa aacacctaaa cattcattcc 76200
ataattttgt aaagaatcat aagtttttaa ttcaaaatca atcagcaatg agtggagatt 76260
ctcatatctt tatatcagta ttgaattact tccacatcca atgtgtattt cttattcgaa 76320
ctttaatgtt cttgttagat gacatcaaga gagattgtct atactcaaga aacccaacat 76380
cgttcagaca attaccccca cagacaaaaa gttgtaggag aagccgagcc gaaggagtag 76440
aagtgtacac atacaaggaa ttagagattg caacaaataa tttcagcgag gagaagaaaa 76500
tcggaaatgg agatgtgtac aaaggagtac taagtgatgg aactgttgcg gccattaaaa 76560
agcttcatat gtttaatgat aatgctagta accaaaagca tgaagaacgg tcctttaggc 76620
ttgaggttag tcgtgcccac ttcatttatt gtccattttt tcttatctac tcttggtgtg 76680
cttatttatt gtttccatgt tatcaacaca tgaatttaat atattagtca taaagaatat 76740
ctaaattgaa attttgaata aaataccgtt gcattgaaac ttttgaaact ttgaaatgta 76800
ttatagttag ttactccatg taggtgactc acgagacacc ggattagaca tacctctcct 76860
ctacaattat aaatatgatc acttgtgata ttttagtaaa acaatttcta caaagaaaaa 76920
tccttcaaat gatattttca agtttatgtt caatttgcaa aaatattgta tgtttaatcc 76980
acaatataat tagccgccac tacattaagt ttgttaaatt atgataaatc atatattaaa 77040
ttaaaaaaat tgtgacgagg agtacccatt tgcttttaaa attttaaaac tctaatgtct 77100
gtgactgtaa tgttttaaaa aaaaaataca tatgagtatt atattacaga taaaattctg 77160
ttttacagat ttgattattt ttgtaatttt gatgtaaact ttaattcgga tataaatata 77220
tatatttaat agacaatgga gtagtttgtg ttttgaaaaa catatcttaa aagtgttagc 77280
tcaaaataca tttatccttt cttgggatta tacaatatat atgttgacca atagaattgt 77340
ttttgaagat tcctctaatt gacatgcccc tttcagaatg tgctgggatt tttttttctt 77400
tggcattcat gtgctaaaat ttataaaaat ctaatcattg cacacatatt ttggtccgtg 77460
tttgtttctg tatatatttt agtagagaaa aagaaagcaa cctttgccaa aaaaaaaaaa 77520
aaaagtacca acggcaacaa aaaaaaaaaa gtaccaaact aagtggattt gtttattaat 77580
tatttaatta gtagtaacta aaaagtctat catgaatacg ctatcatgaa tacatattag 77640
tattcatgaa tacatactac atactagtat aagtattcat gattgacttt ttcgtttttt 77700
ttcttctctt tatttatcat taagaaacga aaaagtcaat tatgaataca ctagtatttg 77760
tttctcataa gtacagtaaa tacatacaat cttttgcaca tcattttgtg tgataccatt 77820
aagtttgtcc atacataagc gaatataatc ttttaatgtg caggttgatc ttcttagtcg 77880
attacaatgc ccatatttgg tggaattact tggatattgt gcagatcaaa accataggat 77940
cctgatatat gaatttatgc ctaatggtac tgtggaacat catctccacg atcataattt 78000
taagaatcta aaggatcgac ctcaaccatt agattgggga gctcggctta ggatcgccct 78060
tgattgcgcc agagccctag agtttcttca tgagaataca atctctactg ttatccaccg 78120
gaacttcaag tgtaccaaca ttttgttgga tcaaaataat cgagctaaag tttcagattt 78180
cggattagcc aaaaccggat ccgataaact aaacggtgag atttcaacaa gggttattgg 78240
caccacagga tatcttgctc cagagtaagt aacacttcac ataattgttt catatttttg 78300
caaaacaatt ttttttacaa aatattagca aagtgtgttg atccattagt ggttgttgac 78360
tatcaatagt gtgtcacttt tgaatttaaa agatggatta tgatcagtca attgctctta 78420
acataaccat ttaaaaactt attgggattg agataggtat gcctctactg gaaagcttac 78480
tacaaaatca gatgtttata gttatggtat tgtgttacta caactcttaa cgggtcgcac 78540
accgatcgat tcaagacgtc cacggggaca agatgtcctt gtctcttggg taagtatacc 78600
gtaatttatt ttcagtaaca tattatcaat ttgaactact caataaacct ccacgagaac 78660
atgtgcactt gtctacactt gtttagaagt acttatatag ctagtaatta attgtcaaac 78720
tgtggtataa attttcaggc tcttccaaga ctaaccaata gagagaaaat tagtgaaatg 78780
gtggatccaa ccatgaaagg tcaatactca caaaaagatc ttattcaggt ctgacttcat 78840
tacttctttc tatctttcct ttgcaatgtg gagtgttggg ttttccctta gtacattcct 78900
atatgacaaa gaaagaagcg tttaatgtgg ttaacttgga aacatagtgg atgtggcttc 78960
gcaaccaata gactatctac ctttgttgtt tgatccacca caacatttat ataaccattg 79020
aactactaat gtgtggatga catacgctat cgagaggaaa tttgtatatg ggcaagagtt 79080
gtgaatatat tttatgaaac aggtagcagc catagcagca gtgtgtgtgc aaccagaagc 79140
aagttataga ccgttgatga cggatgttgt tcactcgctc attccccttg ttaaagcttt 79200
caacaaaagt actgattctt ctcggtttcc tagccgtaga gaaagcttgt catttgatga 79260
tattatgcca tgacactctt ttgtttaata tgtattaatt tctctctttt aagttgagat 79320
tctcgttgtt attgtatatt tgtataggta aatgaatcca tttatcttgt actataactt 79380
atattagtgt tgtttaattg cctagaagtc actcattcta agtccaccaa tattcgtata 79440
aaatattcac aagacttaat gtcttcatcc ttcaatatat cgagaagtcc atgaatctca 79500
gactactagg ccaattcgtt gtgggcctcg tggcccagta ataataatta ttaaaaaagt 79560
ataaagggag ctaagctaaa atgatttttt taatagattc gaaaatagaa agtaagcatt 79620
accttttaaa aaccttctcc tacgaaacgc catctgtctt ctaactcctt tttattaagt 79680
ttcttaaaga aggttaaaga aaaaccctat aaaataaata tcccaacgaa ggcgataaaa 79740
cccagatttt ccagatctta aattctctcc tcccccaatt ccatcttcgc aaattctcca 79800
gattcttccg tcaatctttg aggtaatcaa ttttctctta aatttcccaa cattttttct 79860
gggtttattt cataatcaaa gcttttgtct tcaatttatt tgttatcgag ggctaaaaaa 79920
actttgattt atgatcgttt ctcttgtttt gatgaaatgt atttttattt tgttaatttc 79980
actacttttg cattcttttg tctgattttt atcttgtctg attattgttt tgtctgattt 80040
ttatcttgtc tgattattgt taatgtgttt aagttgtgtt ttttttttgt tttcaatatg 80100
aaacttataa attcattagt gtttttgatg atagaattaa aattaaaaac tttgaaaaat 80160
gtttctctta gtttggtaga gaaatggatc aacaaggaca atcatcagct atgaactatg 80220
gttcaaaccc atatcaaacc aacgccatga ccactacacc aaccggttca gaccatccag 80280
cttaccatca gatccaccag caacaacaac aacagctcac tcaacagctt caatctttct 80340
gggagactca attcaaagag attgagaaaa ccactgattt caagaaccat agccttccat 80400
tggcaagaat caagaaaatc atgaaagctg atgaagatgt gcgtatgatc tcggccgagg 80460
cgcctgttgt gttcgccagg gcctgcgaga tgtttattct ggagcttacg ttaaggtctt 80520
ggaaccatac tgaggagaac aagagaagga cgttgcagaa gaatgatatc gcggctgcgg 80580
tgactagaac tgatattttt gattttcttg tggatattgt tcctcgggag gatcttcgtg 80640
atgaagtctt gggtggtgtt ggtgctgaag ctgctacagc tgcgggttat ccgtatggat 80700
acttgcctcc tggaacagct ccaattggga acccgggaat ggttatgggt aacccgggcg 80760
cgtatccgcc gaacccgtat atgggtcagc caatgtggca acaaccagga cctgagcagc 80820
aggatcctga caattagctt ggcctaataa actgtgagtt cttggtttag atttgtgctt 80880
tatcgttaca tggacacaaa acttgatttg attgttcttg tttgttttcc gcagagccgt 80940
ctaattcgaa gctctccccg gtggatctac tcaagaagaa gaatgttaat agaaaactat 81000
tgcgacataa aaagtttggt gtagtagaat aatttctgtt ttatgatcca tggatttatc 81060
tattgttatt cagtttggtt tatcttgtca tcaaactgtt ttcggtcaat gtaacaaatt 81120
cataaactga gaattgaact tacaaaaggc tagattacta cttataaagt tcaaagctac 81180
agtgatattg taaactaacc agtccttaca catagttttc aaaatggctt agctcgagtt 81240
taaatagtcc gtacttatcc ctacccataa ccaaaaccaa aaaccgacgc ttcctatatc 81300
actaccaaac gtttacacag tttgtttctg caagtttttc attacgactc cttcaagaat 81360
tccatctgtt ccaaagttgc cagaaaactc gtgtggatgg acaggaccgg ggaggcggaa 81420
cgagacagaa aagttaccgg gagggcagag actccgcgtt tgcatttcaa acacatgaga 81480
ataccgttta actcgcttcc cgcctgttgt agtgactcct ctaactagta ccttcccatt 81540
gtcttctact tcacagctaa aatatcctgc aatatctcac actcatcaaa tcaagaaact 81600
ggtttagtgg gatgagagat cttctagata aagcaaaaag taactcactt tcatctcttt 81660
tcacaccagg aagcgataca cggaagagat aagcgtcatc acattcacca atgtccatca 81720
gtcccaccat tagtccacca tgagcttcag atttcacctc aggttttgca gcaacatcac 81780
tttcttcacc gctagtgcaa gtacccgcat tatcctcttt cacaggttcc acgctctcat 81840
caatctcaac cttaacctca ttagctgcaa caacgccgtt acttttagtt acatcaacac 81900
taaggctcaa agcaaagcta tccaatcccg taagccgctt aaaccgcgca acacattctt 81960
ctctcataca agaagtatct ggatcattaa tgaacacaat gctccggata aacttaaact 82020
tatgcctaac atgggtttca gggtgcaatt ttcgcggaaa aagatccacg aaaagagggt 82080
aatccctgtt cgaatcattg cgtttcgcat tgaaatattc acgtaacttt ttcggcttca 82140
tgactagaga cggatcaaca tttctaataa tgtgataata cacacgttct agctcagctc 82200
tcttcataag tgagccactt aactcatcta ccacaacatt cttcaacgct tgaatctgaa 82260
aagctgattg ctttggacga tgatgttgtt ttcttaaatc tggtccaaag taagttccta 82320
tgatgaaatg taagagaaac aacttgtctt cttcaatatc caatgaaatt aacacacttt 82380
cttcttgttc ttgagagttt tcagctacta aaggagacac gatctcaggc attgtatcac 82440
tcatatccta aacacacaac acaacatcaa aagtttgatt ctttatgagt gtttatacaa 82500
aaagattgaa actttaatag aaaatttgaa aaatactgga catgcaataa gaaattataa 82560
ccaaattgga taaaaattgg acacatttcg tatcaaaatg ggtgggaaaa aacgaaactt 82620
tttaaggaga tttaagaaat tgaagcaaat agaaacataa tttgttgata aataaacgaa 82680
attgagataa aatgttacta accaggagtg taaatttagg gttgctgctt agtgaatttc 82740
gttgtctctc atcagagaaa cagaaagcga cttgggaaaa aaactcaaga catggcaaga 82800
agagggtaaa aatggtattc tttcggcact gatttgtcca cgtggcgatt ataccaaatg 82860
tacatcttaa agaaaattaa gagaaaaaaa aaaaaaaatc aacaaagctt ctcggagatt 82920
tttgccggcg acttctgaaa catcgtctcc gatgaggtaa agtaactaat ttttctcaaa 82980
aattcgtcag ttttgtttct actcttgctc ttatataacc caagtttgtg tattttcgtt 83040
tgattctgtg aaagatttaa tttttcttta tgggttttgt acattttcac tgattgaaat 83100
taggttactt ttggctaaaa gtctgaaact ttgatgaaat acttgtgtgc caaacttatt 83160
ttcaggttta aaacttaaac ttatgtctaa gatagtataa tattcattac ttggctaaac 83220
ccttgcttac aaaattgggt cagactcatg tgtgtatcta acattgttgt gtaagacctt 83280
ttcgataaca taaaagagga caaatgatga atgttgcctc ttcgtttgtc taatttgtgg 83340
tcatgaaagt ataagaagtt tccgtttgta tgaatattcg taagcattaa tagtggttat 83400
acatcacaag acttagcttg cttattggat cttaaccaat atagttcaat ctcttgctct 83460
cttactgatt ctagaatcta gctacctcta tagccttata atgtttcaaa gattaagcct 83520
ttttagtccg ctgctgtttt aaagaatcgt tgtagtttcg tgagtgattc tgttatatag 83580
cgaatctgag tcaagtgtat gataaaagga attgttgtgc ttcaggtctt caagtggtct 83640
aaatgggatg agggaaaaca acagttttcc ggataacaca aggaacccac aaattcttga 83700
agtgactcca ttgaacagta tgccttacat tggtccagta actcatgcat ccatgtcgag 83760
taacaggatg aatgatagtg tagagaaagt aggagggcct gcgatgatat ttctgccttc 83820
tgactcaagt tcagagtttt ctaaccttat cagtcaaacg aaaaccggag ttgctctcac 83880
gggaagtgct gcaatgggga agattggact aacgattggg ttggttgata ttgctgaatc 83940
cgaagactca tattactttc gtgttgcatt gcctggtgtt tcaagggatg agagtaagtc 84000
ttaccacctt tccatatctt tgtgaagttt ccaaatgaca tgccaaatta tcatttctaa 84060
agctagttaa agatatttgt tcattcagag caaatattat ttgcacatag atttgagaag 84120
tttcagcctt gtgttataag tgtgtttact caattatttc cttgcacacg gtttataagc 84180
gtgtttatga ggtgctttga gctttgtttc gtgtgctttt acttgtcttc tgctgaatct 84240
gacttgttaa atatgcagag gaattcagct gcgaaataga accagacggt aagattatga 84300
taaagggagc aacaacgacg ggggagcaga cagtttgcaa acacaatcag atcttcaaaa 84360
tgctaacaca gaacttatgc ccaccaggcc acttcaccat caactttcag cttcctggtc 84420
ctgtgagcaa tgaagaattt aacggtaatt ttgggtcaga tggtgtactt gaaggcgtag 84480
tgaagaaggt gtactacgaa gactgaacag aaacaacaaa tggagatgga tttgttgagt 84540
tttaaagtaa gctagaatca ctgcagctta agtaggattt tctttttgtt ggaagctaca 84600
ttgtcatcac aaagattgtt gattagttta tgttactttg taaaaactta actatttgat 84660
acttgatatg cctgatgaaa aaagaattgg agatgatatg gtaagggaat tatgatagga 84720
aatcaattac ctaaaattca agaactcaaa tctttatttt gtaaaaatca acttccacaa 84780
tacctactac atttgtctac tcaattactt aacttctaca agtaatcata tagctaaaaa 84840
agcaacaagg aaaatttcta tgccttcaca ataacactat aacttaactt ccatacgtta 84900
ttcacctcac ctaatattat ttatagtttc atgattcaac acatctgtag attaatattc 84960
tttgaattag tggcataact tatgccctct agggcccttc accatctgtt tccagcttca 85020
cttttgttag caacgaagat gctaggggta aattcgggtc agatggtata ccttagggta 85080
tagtgaagaa gcttaactat gaagaccgaa cagcacaacc gattgagatg gatttgttga 85140
gttcaataca gtaagctagg atcattgcag cttatgtagt attttctttt ttcttgtaag 85200
ttaagatggt gaaagattgt ttattggttt atgctttttc ataaaaagtt acttgatacg 85260
aaatatgcat gaccaaaata ttaataatta taataaaagt ggattattga aaaaacgttt 85320
tacgtgatca cagcgtttat tctaccataa ttttgttaaa ataactgaat ctatagtaac 85380
gacttttctg ttgaatagta tataatattc tataaataaa aacaataaag aaataaagag 85440
agacgagaga atttgagtga aataaacttc acttatttga cttatatctt acaatgagca 85500
aacgaacgta tttatagtag aaatttacgt ggaaacaagt cgtaattgga taaggagata 85560
aacactaaat tatttgggga ataagtaata atggataatc accaaaagta ttatctactc 85620
taatattttc ctatttattg gtgagttgtt tccacatctc tatattttaa aaatatattc 85680
atataaactt gcggtcatta tgatcatgat gtaaaatgtg taaattcata gacatctcgt 85740
cacaaatacc ataaggtcat caatcaacta ttcaaattcg atcatgaata cagtttcata 85800
tctctagagg attgaaatac ataaaatatg acttaaaact tacattcact cccaaaccat 85860
aatcagattt ttttttttaa ttttggatta ttataactaa tgtcttctac gtcccacact 85920
aacttctgtt gtacttctta atttagttat gatgtgtttt ttttactatt cgttaaaaac 85980
aaagggtaaa agatacaaaa gagtcttcac acaaaaacac aacaatcact agctcagaag 86040
agcacaaggc aactaaacaa caaccccatt agccctaaac cagccattac tctcacagac 86100
gtcgccttgc cagcagcaac accagctgta aagcttccac ctggagtact tgtcgtcaat 86160
acaaccacca tccactcttt ctccgaccca acaccagccc cgacatacct cgaatcatta 86220
agataccgag cataaccagt ttgggtgtaa ttagttaaag ccaaagtcgg gatccggtta 86280
gggatacaga caggtaagat caatccgtca cgggtagtgt ttgggtcgat tttgcattca 86340
gagagaatgt cctggtagtt cgtcagccgt ggaggtaccg agccaggagt aaccgtgctc 86400
gctgtggtgt ggtttgtgca tggctgatct tcgagcttgt cggcgatctc atcagccaca 86460
caatcagcct tctcattctt ggcaaatgga ggaactcttt gagcagttcg gtagctgttt 86520
aggccttgaa gaagattatc ctcggcctct acaacattca aaacacaaaa ataatgatct 86580
atgaatgaga aaaattccat ctacacgatt taaatgaaca tgcatgggga tgacattgta 86640
aattccaata ttatgagctt aaaagtaatt accaaagacc tgaataaatg ttattataca 86700
tatatttaca aaacgatcat cttgtaatcc tttttttccg gtgaaaccat cttgtaatct 86760
caaaacacgt attacatatg taaatattta ttcaagaacg agttgtacaa atacataatg 86820
taaatacact aagaaagaga tagatagcca atacgtacgg ttggagacaa cacaagtgga 86880
aatcaaggag aaaatgagaa gatgaatgat gtagaaagag agagacatct tagtaatcaa 86940
gaccattctt cttcacccaa tttctgattc ttatatattc ttgctttctc tggtaataaa 87000
agcagaatta agcgataggc aaaggcaaag agaatgtaat tttgttggtc ctgtactcta 87060
tttgtttata gtatcttaaa ggtctagaat tagcttctct tgataagaat ttgctaaagt 87120
gacaaacact tggcaccgag gaggtttcgt tttgccaaaa gacgacgtgt attaatgcac 87180
atcctcttca cgtgtcatgc atgcacaaca acaaattcga gttaaaatat atatgtatat 87240
atacatataa ggtatagttt ttttttattt tcatataagg tatagttatc cgattatata 87300
gtaaaattaa attttaatta ataaatcttc ttaacgaaga aatttgtcag tgtgtgaagg 87360
agacattgtg tttgtccatg tcatacggat caccacaaat ctggccacgt ttaccaacac 87420
gtgtatcctc ctccgaccat gtcatgttcc tcaacctgcc acatgtcaga tcctatgttg 87480
agatatattg ctacttcaat gtagcatgtt gtatatatgg ccatgaatgt gttgtgtcga 87540
gtgttcactt cgtcaagagt cttatcatca aacgttacgt tctcgttttc tcaaattcca 87600
aacaatacca agaaacctct acttgaaaag agaagattat cgccgcgtgt gtgcctaaga 87660
gcgatggcgt ctgagaaaca aaaacaacat gcacaacctg gcaaagaaca tgtcatggaa 87720
tcaagcccac aattctctag ctcagattac caaccttcca acaagctt              87768



<210> 536
<211> 23918
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> terpene cyclase TC1

<400> 536
ggatccctac tttcacattt ctaagtttag gttaaagatg tatttgatgc aatagctcca 60
gctgtaggat tatctgttgg ctcagctgtg ggtcaatctt ctatagctgg tgaaatctca 120
cagcttatca agacacctaa acttgatgcg ggaatatgct atgatcccga tgatctttct 180
caaaaccttg aaagtgctgt ggacatatta gtagcaacac caggaaggct gatggatcat 240
atcaacaaca ccaagggctt tacgcttgag catttgcgtt accttgtatg cagaatttcc 300
tgatttgcct tctcagttct tcttgttctt agtttccgtt tgatcgatga agctaattgt 360
ttcaggttgt tgatgaaacc gacagattgc ttagggaggc atatcaatcc tggctaccaa 420
ctgttctgca actgactcag acatctgacg atagcctatt tccttcattt acaccatttg 480
ttccttccgc ttttggttct ctgcagactg ttcgtagaca gtgagttccg tgttactagc 540
ttatttcttt tcgtatgcta atagtagtca cataataaca tgatcatgtt aaacgttgta 600
atcaaaactg attaaaaaga actaatgtga tgtctgcttt aaaatctcag aagtgtggag 660
agaggattca agggtaaacc atacccaagg ctggtgaaaa tggtactatc agctacattg 720
acgcaggatc caagcaagct tattcagctt gacctgcatc acccgttatt catgacaact 780
ggaggaagcc gatacagact acctgagaag ttggaatgtc ttagactggt atatatgtgc 840
ctttaatgtg tcggttttca tcaagtttgt gctttaacag aagatttatc tacaaaagct 900
tatctccaca actttcttcc catgtctttt aacagatttg cgaaaccgga atgaagcctg 960
tatatttggt tgctctccta aaatcatggg aaggtgaaaa gtgtatcatt ttcacatctt 1020
ccgttgagac aactcgtcgt ctatgcaagt tactcaactt ttttggtgac ccaaaaataa 1080
aagcaaaaga gtattcaggt ggtcttaacc aatcacttcg gaggtaatat tcgaatcttg 1140
cattacttag tagcaccgta tactatcttt ggaactcaga actaacgaat tcttctcatt 1200
tattgaacaa aatttgcctg cagcaaagaa ctaaaagcgt ttagaaaagg tgatatccaa 1260
gttcttgttg catctgatgc tctaacacgt ggaatggatg ttaaaggggt aacaaatgtt 1320
attaattatg atatgccacc atttgcaaag accttcatcc atcgtgctgg acggacagct 1380
agagcaggcc aggctggccg ctgcttcaca ttgctgagta atcatgaggt aaactgatat 1440
tatgtactac acaaacacag aaacattctt tctctatatg cttgtccacg ttctctatat 1500
gcttgtccac gtatgtgtaa acacaagctt gaggtacctc agataaaaga tactaggtaa 1560
agcattgtgt ctgaaacagg gaagaagatt cagtttcata atcttgtgct cacctcactg 1620
aatcattaat ctcttaggat aaatgtatag gaagactgct ggaacccacc ctctatctga 1680
tcctctgcta ctttttatat actgaagctc ttgactctag ctccatttgc tcattcggat 1740
atataaaaat ttcaggtaag gcgtttctcg aagctcctgg agaaagttgg gagtgattca 1800
tgtcctatct atccgatccc gcctacttca ttagattcca ttcgtgccac ttacacaccc 1860
ggtaagtacc tagccttgtg tatatagctc taggaaacac tctgcagata gacatgaaaa 1920
ataggggagt aatgtggaat tgagaatcag cactgctgct tagttgttaa acctcttaat 1980
gagcatgtga atttagattt agagcattac tttacaaatg tagatttaga gttttatgga 2040
accctgtcag tgcataggag acattagagg ccattgaatc tgttaactat attttggtaa 2100
tgatgatgat gaagtcattt ctcatttcag ctctagagaa gctcaaggag ttggttgagt 2160
cagaagcacc caagaaagga agacaagctt ttagacataa ttcaagaacg ggtaactccc 2220
aaaccaaact taacaaaccg agatcagaag catagttctc ctgtgatgat ccctcgggtg 2280
tgtcgggtca agtacaagtt attgggtttg gatatttctt gacttaacat tgttcgttga 2340
ggcgaagaat ccattgtatt actgagaaac tacagtataa cgctgacaca attcgtcaca 2400
aaaattttga aactattttt gctataaatg tttagtttcc aattgcactt cgtagaataa 2460
tctcagatta ttttcttaga tttttggata ttagtattta ttactaattg tcaaaaaatt 2520
aaaatttaga agacttcgtc aaaaaatata tatttacctt tatcaattaa taaaaaaatt 2580
caatcccgaa ttaggactaa tgtaaaaatt gatacaaatc gataaattaa taagataaaa 2640
aaaaattttg aaaatattat ataactatat ggtctcatca atagtataaa ttaataatta 2700
tataaattca ctaatatata tattataaat attatatgta aaatatgact gtaataattt 2760
tttttttcag tttttaataa ttctttgtag tgttcaattc taatatttta caacatcaaa 2820
aaaatttgta ttgtttttta gacttaatca ttgcttttta cttgtaatta ctattgatta 2880
taaagaaaaa aactacattt tttatcgaat ttttgtaaga atttacaaac tttgtacaat 2940
tttataaatt tatcgataaa ttaatacctt tctaaattaa tcaatttttt gtcccaatat 3000
tattaattta tagaggtaat actgtaataa ttttttgaat ttacctctaa ctgaatcctt 3060
ggaccagtgg caatatgggt aaatatctca aactatgcat tgtttcttaa ttttaaaata 3120
aataaataag aaattgtgtt tacaacggta ttattttgta tgaaacgaga gccttttctt 3180
tcactcagaa taaaaccata cctttctcct aatttttctt acgaagatca aaatcaagaa 3240
acgacgacga aacactccac cactaagatt ccgtttacta tcattgtctc atctcttttt 3300
tttttggcaa aaacattgtc tcatctctat tttttgtttt ttgggtgttt tctatcatta 3360
tctcctctct ggttttgaat ccttggaacc caagaaaacg aaacccaaat cccaatcttc 3420
atcactcaat ctcttgtggt aagaaatttc ttgggtttga agagttcata tgtttgttta 3480
ctcagtttcg gttccgtttg tgaaacaccc aattgctttc ttatttcctt tcgcagttca 3540
aaattaaaat caagatatcg agaaattttt ctttatttct tatgagtcaa gatcaaaaac 3600
ccttactttc tctttatttc cttaggcaga gttcaaaatc aaaaccaaga agatatcgct 3660
acttgagtct atacgctccc agtcaccacc aaatcaattg gcactctgaa ctgagagaat 3720
ggaggtgaga tatttgatcc ttactcttac ttagttccgg ttaaagcata tgaaagactc 3780
aaattttttt acttttgaca cagaggcata aagaagaaga taacggtgga gacatgatcg 3840
acaagtggga gtgacataca aggggaatag gttctaagtt gatgtcgagg attggttatc 3900
gaaaattatc tcgtttgggc gccttgggaa atggcatctt agagcctatc ctagtagtcg 3960
ttcttccacc gagggtctcc ctagacattg ctctttatct tattactagg gacaaagagg 4020
aacgcaagaa agaaaaggag gaaagaatca gaagtgggaa aaggaaggac gaggcaatga 4080
gcatacacaa cgacattgtt tagcagctcc atgagcaaaa cgtcctttca tcggaatcat 4140
ttgacaaggg acaagacatg catgtggaag ccaatccatc ccaagctgtc ttcctctcca 4200
acaaccctga tggtgcaaaa gaagcactga actctctgac acaggagaaa agcatggaac 4260
aaaatgcatc tacagaggat tttgagctta ttaacaagga agaatatgat agcaagaata 4320
agaggaagag aaggagccga ggttggaaaa gaaagcgtga gaagaagttt gtgtaaaaac 4380
tttagaatta taaaaagtga tttctcatta atcatctaat gtgacattac atcagtatat 4440
atagtacaca agatgagtaa ataactagaa tcatgtaaat ggaagcttaa tcataattat 4500
gctcatataa ggttaataca cccccctcaa gccaaaggaa ccaaatgtga gaagaggctt 4560
gaaacagata gtcgaccaag aatcgaataa aatggacccg gatgcaaggg cttggtcagt 4620
acatctgcaa gttgattacc cgaagataca tgtagaacac tcataaaccc attctgcact 4680
tgatcacgag ttgtgtgaca atctatttcc acatgtttga tcatctcatg aaaaacagga 4740
tttccagcaa tactcagggc tgacttgttg tcacaaaaaa gcttcggaga aaatccatag 4800
caatgtgtaa atctttcaac atttgaacca gtcggtgatg tataaccctg aggcaaactc 4860
atgtatatct cttcatctaa atcactatgc aagaaagcat tagtgacgtc catctgtgtt 4920
aaactccatc caaaccttgc tgctaaacca agaatcaact tcacactagc caatttagcc 4980
acaagagaaa aggtatcaaa gtaatcgact ccttcatgct gtgtaaagcc tttagtaaca 5040
agacgagctt tatatctttc tacgagccat ctgtagtata cttaatagta taaacccact 5100
tacagctaac aacattctta ccttgaggca aagaaaccac actccatgtt ttattaagtt 5160
ccatagcttc aagctccaca tccatagctt ttgtccattg tagtgatatt atggcttgct 5220
taaaagtttt gggttatgtt tcaagagata ttgaaaagat aaattgctga aaaggggatt 5280
taagtgttgt ataagggaga acagatgaaa gaggatatgg tgtggtgact tttatcggtg 5340
atggaggctt agaagtttga atgagacaat tcagataagt aacttggtac cttagtaggg 5400
tgtttcggtc tgaccttagg tactgaaatc actgcagtat ctgtagtaac agtctcccta 5460
gaaccaaatg atgtactagg tggattttgt gtatgatgtg tttgagatga tggtgatgaa 5520
tgatgcgcag tatgtatgtc agatgaatct aatgcaacag gaataggtaa tggtgtaata 5580
gatgcaggga aaacatcaca cgaatctgtc agatgcattg tatcatatgg aaagacagtt 5640
tcatgaaaca ccacattacg agagactgaa atgatattag tatcaagatt taaaaccaga 5700
tgcataacct aagaaaacac attcatttgc acgttgactg gacttatgtc tatctttctg 5760
taaagtagaa acataacata aacaaccaaa gcaacgtaag aaatcataag cagagctttc 5820
ttagttaaca attctattgg tgacaagttt ttcagtaatc gagatggagt tctatttatc 5880
agaaaaaact gcagttttag aagacttcaa aaaaataaaa aaacttcgta gagttatgaa 5940
caaatttgtg gggttcaaat gatgtgaatt ccgctaaatt gttggagaca tgattcttcc 6000
atcagatctc cacacatttt gttattcaat taacaaaaaa aaagatagaa atagaagctg 6060
aaataaaaac caaatatact aattatattg tttcaaagac gaataagatc aacaaacaaa 6120
gatgtgatat gatccttaaa tcttccttcg ggatgtgtgt attcttcgcc agacctataa 6180
gtgaactcta tcatttttcc aaaatcaatg gcccgcttta gaatttgccg cggcacactc 6240
tttgttgtct ttaatatctc ctcgttcaca gttgtatcca agtccctagc catcttttga 6300
agccttgtga aagtttcctc ctcggtaact ttgtattgct tcatatagta catgatggca 6360
ttaacatcaa accctctgct catgtcaccc tgttagatat tactagtcat gtttaacgta 6420
taatgtcttg atcactaacc aaacaagaag aaacgcttga tcatacaatt tttggtacct 6480
caaagccggc tatgtcattc attagacgag cccttttagc ctgagcctca acaaattttg 6540
gtctggattt tagccattta taagcttgtt ccctagaact ttgtcccaac ccaagaaaac 6600
tgcatgctat acttacatac attgttactt cgactcctcc aatctccaag tactcgtcaa 6660
atgtaggcac cacgtctcct tgttcccact tggtaaagca aaagttggat cttaagtata 6720
ccttgaactg cttattagga gcatatagaa gcacgttaaa caacatctaa ctatttaatt 6780
ttttgatatt tggatgttac ttatatatat acactacctc ttcaagtgca ccttgcacgt 6840
cataagacaa tccctcttcc attatgcctg cgttttcaca ctcttcgaaa gtattccaag 6900
cgaacttgaa gacggttttc atataatctg gtaaactgtc catgcaatct ggatcccatc 6960
tgtacatgca tactgagata tttgtacggg atatatattc accaaaaaaa tttaccctat 7020
gatctattat atatgaaacc atatttctag aaaaatttga tttcttaatg ttttgtgttc 7080
atatatttta tgattttaca tagatattaa agaaatagac agaataaata tatttagtca 7140
cgtaaagtat tggaataatt aatgtatttg atttcactta ggatctctaa tctatttcac 7200
taggattttc tttcatggtt gggttggcac tggcctttga gataagatac gcattcgtgt 7260
ttggatgatg ttacctttcc acgcattgaa caagagctgc aacttcagaa acattaccgt 7320
atctatcaca cgtgtcatca acaagggtga agactgtgtt gatcttagct agtgaaactc 7380
tcccaagtga aaattgtggc tcgaaatata tcattattgc aaataaatag cattcgatca 7440
atctatccct gaagtaaggt gggagtttag atgcaaggtc ttgctgcttc caccatctgc 7500
aaaacatgtc aatgactatt gtcaacttgt atcgcaaaaa acatatagct agaagcacga 7560
aaaatctaga gtatagtact tggtcagagt tttcaattct tgaatccaat ttagctgcaa 7620
aaacttgaaa ttgatcttgg caaatctaag tagcatcttg ttgtgatctt cttcttgttc 7680
atagaaagaa atgtattccc tcgcgaatat catttcggca ttgtaatgtt gaggcatgca 7740
aagagcattt cgtatacgca ttaagatatg gggagaactt gctccagctc tagctaacga 7800
ctccaagttt cttgtagtga agcttaacgc ttcctccaag atatcttctc ttgttgtcct 7860
taagtgagca gcttcataca aactcaccat gcccttgaca tcactggtta tagattccat 7920
aaacttttca ttctcccctt tgaatctctt gaaaacatct attggtcaat aggagaatct 7980
tgttaataca tatgaatcga ttacaaaaaa atgtactggt agataacttt taccggtaga 8040
catgttgtaa ccgtatgtcc tgaaaaccca aaacatgatg gaaatcgtgt acaaatcatc 8100
ttcaccggct atcatctcct gtatcttttc aaaaccctct tctagactct gctcaatctc 8160
atcttcaaag tgaaacgcta caccaaggct cacaagcata tatatgaaaa gaatcctctt 8220
cttggtcgac tcaatgcttt tcgaagaaaa catgagcatc tcccctactt ccggctttag 8280
tctctcaatc tcttgggcaa gggcattcat ttcctaacaa taatatcata tgttcatacc 8340
cgttacatcg atcttttaca tttattatat atatgtttgt cagtgtgtat tatagactca 8400
ccgagacatc aacttgagca gagaggaaat ggtgacccca ttttgaaagc ggcagtctct 8460
tgaacttgcg attactttct tgatcatgac aggcccgagt aggggtggcc ttcatgcgaa 8520
caagctttcc atgctgacct gaaaatgact tgtggggaaa gctagagagt tttcttaccg 8580
aaaataaatt ggaacgtaaa ggaagagaga gtatagatcc ataagctgat atgcattgca 8640
tgtttactac tagtgatatg gaatacattt tcaccaccaa atttataggc aaaacataag 8700
cgttttcatt aagtcatctt ttgaaaagtt ttggaagaat gtatattaat acccccatat 8760
ttatcttctt cagtgtataa tacaacctat gttgggacca tgatattttc tgaatttata 8820
gtgatattag tttatcttta aattgatatt tattaatcta tatagatctt tttttaatta 8880
tttaattttt taaagaatac gagttgacac aattcaatat acatcaaatt aatgacttgg 8940
atgttgaaat ttgtgtagta ttagaattga aaatttaata tttcaaaaaa ctcatttgac 9000
aataaatcac aatgactata actgaattca tttatataat agatatacat acatctaagt 9060
ttatgattaa taacctcaac tatcagattt ttaaatgtag tagactattg aaatgaaaat 9120
aatgcagatt aagaagttgt atacttataa aaacttatga ctaattgtat taggaagtta 9180
taaacgatac tacaatatga tagttttaaa acacaacata atttaatgaa aattagagac 9240
aaaatcattg tttgatgtaa taatagttca agacaaactc taacaaacat tcaatagttc 9300
aaaaaatatt taaactatag attatatata ttatcgtata tatattatat ttttgtggtt 9360
attaatttat gatgttatta aaatcatatt ttttatatag ggttttaaaa aattgttaac 9420
ttattatttt atcaaattat gttaaatttt acattcacac gacttgaaac taatataata 9480
ttatctcctt gtatttatta atttatcaaa aattaatttg tagaggtttt actgtaaaac 9540
atgtttagtt tttcattttt taaaaaacct ccaagtggca aaaataagat ccatctccat 9600
ctaaaaaagt gcaaacaaat ctccatcatt taaaaatcaa cgttaacatc catatctatt 9660
gttgttgttt tttacttctt tttctcttgg tcaaactcta cgttagtttg atcaataaat 9720
atgacaagaa tttttgcagt ctcataggcg tctttgtaaa ggttagttag cgtctacata 9780
attttccgaa agatataatt ttcttgagat acagttaact caattactga aatgtaataa 9840
ctttctaaaa gttgtggcta ttaaacaaaa ttgtgaaaaa atttaaacca aaagccactt 9900
caaaaacaaa gaaaaccata accattaatc aaaattcttt tttttttgtt aacaagtact 9960
agttgcatta aattgtaaac atatggtggt gttgtatatg tttgatacaa agaacctata 10020
taacaaaggc ttgttgggat agtgcatctg ccacattatt tcttttccga ttgacatgtc 10080
catagatgag tgtgatagct tcaacatcca atatcgtata ccaccaaaga ctgaagagta 10140
gtaccaagaa tatttatata tatatttatt tatttattta ttttggtaag gagaatattt 10200
atatcatgat cccaccatac tttaattgtt atgaaaaaat tttaatttga ttttcataaa 10260
ttttatagtt tagttaagta taaaaccaca attttttttc tttcaaatat tatttttgga 10320
gaaaaccccc aaatttaaaa ggaaagagaa aaaatcaaat cattcatctt tgagctttct 10380
tttcttctac agaaccctaa tttcatgttc taggtgtctc tcgaatggtt ctcatctcat 10440
tgattactca atctctaggg tttagtggtt catccaaatt cgtaccctaa tgggtgccgt 10500
agcgatcaat cgtaaacgca gcgacgaatc cttcaatttc attaatcaac aatcaaccaa 10560
ccctttacga aattcaccgt atttccaagc ttccaagaaa cgaagattct cattcgctat 10620
gtctgaagat tctggtaagc cagcgtcttc aaacccaaca atttcgagga tttcaaggta 10680
ccctgatgct aaagctcctc ttagacgaga gattcatgct cctagtagag gaattcttag 10740
atatggaaag gcaaaatcta atgattactg cgaaaaggac gcaaatttct ttgttcgtaa 10800
gtatgatgat gcaaagagat cagctttgga agctttgaga ttcgttaata aaggtaaaga 10860
ctttgttgat ttgggtgatg aggttgaaaa ggaggaagtt gtttctgatg attcaagtgt 10920
tcaagcaatt gaagttattg attgtgatga tgatgaggag aagaagaatc ttcagccttc 10980
gttttcttct ggtgttactg atgttaagaa aggggagaac tttagagttg aggatactag 11040
tatgatgctg gattcgttgt cgttagatag agatgtcgat aatgatgctt cgagcctcga 11100
agcttataga aagcttatgc aaagtgcgga gaagaggaat tcaaagttgg aagctttggg 11160
ttttgagatt gtgttgaatg agaagaagtt gtcactgctg cgtcagtctc gcccaaagac 11220
tgtggaaaag cgtgttgagg tgatgagatt tatactaatc tttcttgaat tggatataat 11280
taatgacatt gctttgtttg gattgtttct ctaaaatgca tatgatgtta tcgcctactg 11340
tttgttagtg tagactgaag atagtacaat acttgttggc tttattggtt attaagctgc 11400
agttattact tatgcacaca gagtcaaagt tcttctactt attagagtat attgtaatct 11460
tagcgttgag atcgttagtg tgtttctatg tttattgttg ttgttaacac tatgtttgtt 11520
gtgttgttga tataatgaag gtgcctcgtg aaccttttat tcctctcaca gaagatgaag 11580
aggctgaagt ctaccgtgcc ttttctggga gaaataggta tggtttctta agacgctcta 11640
gcatgttgag tgattttttt tagtctaacc aaaaaccaaa tgtctcccat ttttcagaag 11700
gaaggtcttg gctactcatg aaaactcaaa cattgatatt actggagaag ttctgcaatg 11760
ccttacacca tctgcatggc taaacgacga ggtacaactt gttccataat attctacaca 11820
attaagagct cttaaatcac attttctttt gctgatttct tgttctgttt tataggttat 11880
caatgtctac cttgaactac tcaaagaaag agaaactaga gagcccaaaa agtatttgaa 11940
gtgtcactac ttcaatacct ttttctacaa aaaggtttgt tttctttctg ctcagatgat 12000
ttttaacaaa aatttgatcc tttttgcctc atgtcagttc gactgagtag ctgctacttg 12060
cttccataaa aatgataagc agtatgttta agtgatcttt atgataagat tattgatata 12120
tttggccttg tttctcccca tggtactcag ttgtctctgg cttctgtatc ccatgaatgg 12180
cagtgagtaa ccaagacaag ctgtggcctt cttatacgtt gatgaatcct ctggcactta 12240
aatctgtctt tctttaatta tttttttcag ctggtaagcg attctggtta taattttaaa 12300
gctgtcagga gatggactac gcagagaaag ttgggatatg ctcttattga ctgtgacatg 12360
gtaattttgt cgaagaacct gaatttgaag attctcttgt taatattacg catgtagtcc 12420
aatttattta tgtttaactt agtctgtgcc ctctgcagat atttgttccc atccacaggg 12480
gtgtgcattg gaccttggca gtaattaaca acagggaaag caagctcttg tatcttgatt 12540
cactgaatgg agttgatcct atgattctga atgctctggt atgatttaat ttctaactct 12600
tattcgcttt atttagtcta ttaataactg acatgttgga tgcattaaaa gatattagat 12660
gctgataaat ctttatcatc atttcttgat tctgaaatct gtttggagac attatggaga 12720
tgccagaagc tgttattgct ttttaaatcg gacactactg tgaaagtgtt ctaaccatat 12780
atactagtcg ttatagctaa tgccagatct gatattctgc ttcaggcaaa atacatgggt 12840
gatgaagcaa atgaaaaaag tggaaaaaag attgatgcta attcgtggga catggaattt 12900
gtggaagacc ttccccaaca aaagaatggg tatgtaacta tgcttgaact tgctatgatc 12960
catgatcatg tgaaaggaac tatcttgtta aagagataac ctctgtagaa tcagatactt 13020
gtcttctgat gtgggaatat gggtttttaa gacaaaggat agatctggtt tgagattgat 13080
taggagaaat tcacctgata taaattttga taatggaatc aacaagggta taacttaact 13140
gttcttatgc tctttagcac tctggttaag ctctctgcta actctatatt gtttctttgt 13200
tgcaatcttt tatattctca ggtatgactg tggaatgttt atgcttaagt acatcgattt 13260
tttcagcaga ggcctggggc tatgtttcag ccaggtaagc tatcagaatc caaatctctg 13320
aatgcctcaa gaaactgtag ttgagaataa aaactggttg tcttgaaaca atatggaatt 13380
agtatatccc cctagcagtt tatgtaactt gtaggattta ggcatttagc gtaataacat 13440
tgtattactt tgcaggaaca catgccatac ttccgactca gaacagctaa agagattctg 13500
aggctacgag ctgattgaag ttgcttgtgc taatgttttt tcggctatta ggaatactat 13560
ttttggttgc cattgttgat ttgttcaaac tttaaatccc actcctttta ggcagtgaag 13620
cactcggctt taaaagcaga ggtaaaaact gagtcaagcc cagagctctt agctcgttcc 13680
gttattgtat ttttttcctt cttcttgttt taaaatgtag atgaagcgtt ttggatctct 13740
atgttggtta gtctagctga agatatatga gatgttgaaa accttattta tttctctccg 13800
gtcttgacca gtgcgaacgc aatttaaagt ttccatctag tatcggttcg atatattttc 13860
ctctgttcaa tagccaaaat tccatgaata atctcttgaa agcaaatgtt ttcgatatac 13920
aaatgttctg cacaatttcc ccaatacata cacgaatatg ttacaaatat acaacaaact 13980
gctgtttgtg agtacaaatg ttgacaagga cacagaaaaa acaaaatccc aaatgtaaca 14040
ttgacatatt aaaacccact cccaaaaaca aaaacaaatt ccccaattca taaaacacga 14100
gaggaaggaa gacttgtgtg tatctcctaa caaaaactga ctggaaggca aactaacttc 14160
cactgccttt cctagcgcgg aactctcttc cggctaagta tctcctgttc tttcagacgg 14220
tgttggaacc gagcaagacg ggcttgaaga cttacaagac cagctgcttt acgggacaac 14280
acaaagctca gctgtgtaac atagttgtca atcatgctcc ctggccgatc caccttcgct 14340
agtaatttca tttcctacaa aaaaaaacat gaaataatgt taaaacaatc acaagacata 14400
tgagccataa cctcgtgaac tatttccatt gtatcctcga tctcttttct gtgtgctgta 14460
attaaggtct cttcttcctg ccagagttta aacaaaataa ttaccatatt acaggttttc 14520
taaggttatt cgtgagcgat attcataaaa ttccctcacg ctcatagcat aatttagaag 14580
tatagaaggg tcaaatggct ctttacctca agcaatgcat caatgttttc atcaagagaa 14640
ggctccgttg tttcatactg ccttgaagat gtatcgcttg tgttctgact gctagccata 14700
ttttgttgtc tagaatttgt catggcaggg acatcagtct tgagaataag atgagtgaat 14760
cctttgacta gtggagccgc caaaagaaga ttttaaaatg ttaagcataa atcatattcc 14820
ttaaatgtta agtgaatcct ttgactagta tagtatagtg tctggttttt cattagactt 14880
tctgagatga gaggtatttc tattaaaact taagttgaag gttttaaaat gaatcagcca 14940
aaactgcagg gtttgtttca ttaaaatccc aaaattgttt cgtatacatc atattaccca 15000
ctgaggactc tgctctttgt ggaaatgcta aattagcccc aaaccttttt ctaagtccca 15060
ctttgaattc taataagaac gaacagatcg cgggaaatcc aaaatgattt gaaacctttt 15120
cacctgaatt tctgtgaaat ccaaaattct ctctctatca gtagagaatc gccatggatg 15180
aagagcttct gctcactaga atccttgcag gaatcgaagg aggagacgat gaatctgact 15240
atcatgaact cgtcacggat ctcaaatctc tacttgatac agacgatgat gaaattctca 15300
atcgattcta cggtagtctc tcctcaatgg cttcttcgtt tctccgctgt atctccgccg 15360
ccatggattc tccggttgaa tcaggccgtc ttgctatttt agcctccgac gcttatctca 15420
gtctgcttct ttccacgaat tgccccgttt tcactttctt ctctccgatt gcgtttcttt 15480
ctctacttgg ctcaattcgc cgctacctca aacgccgtga tgattccgcc ggtcaaggga 15540
gtaattcgca gcgagagaaa gggaataaga agaagagagg acgtggtaag aggaatttag 15600
ggtatgaaga tggggaagag actgaagaag gtggatttga tgcgaaattg atgtttatag 15660
tgttagagaa gcttggctcg gttctgagtt ttgttcattt agatagattt cctgatagtt 15720
tgaaatcttt ggtacaaact gtgagtgaga ttcctttatt ggcgttggag cactctggag 15780
ttttgaatta tgatcgattg atggaaatgt gtgggaagat tctgggagga gtgttgaatt 15840
ctgaccatgg agatatggca ctcactgctg ctgagatttc aaagtctttg acaccgttgc 15900
ttcttatggg gaaacatcaa gcgagaagtt ttgcgttggg atttgtgtca aggaaattga 15960
tgagtttggc taaagataac cctgaattga aaaaagttgt gtctaatttg cctaagtttc 16020
tggttcataa ggcacctgag aaggccgagc cgcgtggatt tgcagtggag gcggtactgg 16080
agattgtaaa ggcaatggag gttgagggcc aatcagagtt tgttgatttt gtaatgaaga 16140
tgtgtcaagg gaagtctaat tttagagtat tagctgttga tattatacct ctgttgataa 16200
gctcattagg aaaccctcta ggagatatta gttcagagaa tgggttgaaa gattcgtggg 16260
gcttgggttg tattgatgct ttagttcagc ggtgttcaga cacgagcgct ttgattagag 16320
ctcgagcttt gtccaacttg gctcaagttg tggagttctt gtctggtgat gaaaggagta 16380
ggtcgatcct gaaacaagcc cttgggttta acggtgagac ttcagaggga aaaggtgcag 16440
taactgacct tttgaagaaa agatgtgtgg atgagaaggc ggctgtaagg agagcagctc 16500
ttcttctggt gacaaaattg acatcgctta tgggtggttg ctttgatggt agtatcctaa 16560
agacaatggg tacatcttgt tctgatccgc taataagtat aagaaaggct gcagtttcag 16620
ctatttccga ggtatgtttt ctgtaactca gtttcttctt tctcatttac ccgatggtaa 16680
tatgtgtaga gttagtataa tttatacggg tttgctttga ccttaattag ctcaaagtta 16740
aagagaccaa atgtgcaagc caaaaatgtt tttagatgaa tgaatgggaa attacatagc 16800
aactgcttcc gtcggtttca tactaaaatc agataatctt tatactttaa cttatccctg 16860
aatataggtc aggcactcag gctaatgact tgttatcata tttctctgat gatgcaagtt 16920
cattgtcttc tgttcactgt aggcattcag aatatgtaca gatgaaattg tgaccactga 16980
atggttacat tctgttcctc ggatgatcat ggacaatgaa actagcatcc aagaagaatg 17040
cgagaatgtc tttcatgaat tagttctgga gagaatatta cgagctggaa atgtgctttc 17100
tccagacagt gcttctctcc ctaacaaccg gaacactact tcaaaagatc tagacagaga 17160
cattgaagcc ttgtttccag aaggagtttt ggttctctta agggagcttt gcaacagtga 17220
ggtttctcct tgggttacga aaatatgtgg aagtttggga aagaagaagc gactaaaacc 17280
aagagttgcc cttgcgcttc agtgtatcat aaaggaatct gaatcactgt ggttgagtcg 17340
ttcaatgcca ataaatagat ggacagctcc tgctggtgct tggttccttc tatcagaggt 17400
ttcagtttat ctttcaaagt ctgtcgaatg ggaatttctt caccatcatt ggcagttgct 17460
tgacaagaat gacgtacaag gtttgtcaga attctgttta tccatctata aacatctcaa 17520
tcaactgatt catgtcttta cttgttccta ctggtagtgt gattttctgg ttttagtcct 17580
aacttctacc ctaattaaac caattttcat gaatgtatgt atgataattt ggctatttct 17640
gaagggctag atgaacaagg tgatgaacag ggggtcgagt gtaattcttc tacatgggct 17700
ggcgatcgag tttgtctttt gcaaacaatc tccaatgttt cccttcagct gccagcagag 17760
cctgctgcag atctggctga caatttgctg aagaaaatcg aaaattttaa cctgcattct 17820
gctgaggtaa tgataaatat ttaacctgat atcttctata taaaatcaag ctcatgtttt 17880
gaaagtacag aaagttactg gtttttgtct agaaggatgt attctttcag attttgatat 17940
ttttttggta cttttctgta acctgaaact tgaacgcttg aattgagcag atcattattc 18000
actggtttga aaatggttgc ttcgtatatg gttcatctat cttcatgaac ttagtcaatg 18060
ccattgaatg acaggtcgat gcacatgtca aagcattaaa aactttgtgc aaaaagaagg 18120
caagcacctc tgaggaggcc gatatgcttg tcaagaagtg ggtagaacaa gtttcattga 18180
aagcatctaa ggtcactgag aagtacatcg agggggtttc cagtcataat cattcttttg 18240
ttacaccagc aacactcgga agtagaagaa gcaagagact ggatactgtg tccaagaaat 18300
tatcaaaagc agtcacagca gtatacacca ttggatcttg tgtcattata tatccttcag 18360
ctgacacgac caaaattgtt ccgttcttac atactgtcat cacttcagga aattcagact 18420
caaagctgaa aaacaaactg ccgcaagcta atgtttgctt gaagcaaaaa gctcctcttc 18480
tctatagtca gtcttggtta accatggcga agatgtgttt ggctgacggg aagcttgcta 18540
aaagatatct ccctctcttt gcacaggtct gtctgcattt gctgattcat gtgtccattt 18600
tatcattttg attatttctg gaaaggaaac ttttcgttcc aggaacttga ttcattggat 18660
ggtagtctcc tttgtctctt caattttttt taacctatgt gaacccgttg atgccttact 18720
cttgcaggaa cttgaaaaga gtgattgtgc agccttgcgt aacaatcttg tagtagcgat 18780
gacagacttt tgtgttcact atacagccat gattgagtgg tatttcattc acagaacatt 18840
aatttttcaa atgttaaaca tgattgcgac attctaatgg tttgtttacc tggatagtta 18900
cataccgaag attactaaac gtcttcggga tccttgtgaa gttgttagaa ggcaaacctt 18960
catacttctc tcaaggttac tacaggtatt gctattctcc acagattctt tatcttctgt 19020
ttttaaaaag tattgaattg acaatgaata agcaggcttg ttttcttgat tcagagagac 19080
tacgtgaaat ggagaggagt tctcttcctt cgattccttc tatcgctagt ggatgaatct 19140
gaaaagatac gtcgacttgc agacttttta tttggaagca tccttaaagg tatgagaact 19200
cacgtgagca accatgaaat gcattctttc attcccatgt tattgaaaat tcttacagag 19260
agacatgatc tctaggattt ttgattattg ttacgcccca tgttgcttat agtaaaggcg 19320
ccacttctag cttacaacag tttcgtggaa gctatttatg tcttaaacga ctgccatgcc 19380
cacactggcc atagtaatcc agattctaaa caatcaagaa caaaggatca agttttttct 19440
atcaggtact tgtgttaaag ttatatagtc tatgctcata cgcaaacttg acattttggt 19500
gtgaatgatc ttagtgatta tctttgtttc atttgttctg tagagggaat gatgaaaggg 19560
ctaggtctaa aagaatgcag atctacgtta ctttgcttaa acaaatggcc ccagaacacc 19620
ttttggccac attcgccaag ttatgtgcag agatcctcgc agctgcttct gatggaatgc 19680
tcaacataga agatgtcact ggtcaatcag ttctacaggt aacttccaaa atggctacag 19740
agcctttttt cttcttgtga ttgccgattt ttaactcgtt ttgtctcggt gtaggatgcg 19800
tttcagatct tggcgtgcaa agagatccgt ttatcagttt ccagaggagc atcgtcggag 19860
acagcagata tagaggaaga aggtggagat gcagcaactg caaaaggaag ggccataacg 19920
cacgctgtta gaaaaggttt gattcagaac acgattccaa tcttcattga gctcaagagg 19980
ctattggaga gcaagaacag tcctctcaca ggttcgctca tggactgcct ccgtgtcctc 20040
ctcaaagact acaagaacga gatcgaagaa atgcttgtcg ctgacaaaca gcttcagaaa 20100
gagcttgttt acgatatgca gaagcacgag gctgcaaagg caaggtccat ggctaaccaa 20160
ggggttgcct gcgggacaag tcatagaaac ggtgaacctg aagcatcagc agcaagcgag 20220
gagaatgtta gagattcggg attggaatca agagtggttt ctgcggctgc tgatgtggtg 20280
gcggctaagg cagctaggtc ggtgttgaga gaagtgaacg gtggagctgc aacgccgcct 20340
ctgagcgcaa tgagtgttcc gaagctaagg tcgagccgtg gagttagcca gagtggtcga 20400
ccatcagctg atgtgttgga gtctctgaga agaagaccaa ctttcatgtc tgatgatgag 20460
agttagaact taaaaatgag actgtagaaa atagcttttg ctgtaaatgc atgacttcga 20520
tttttctttt tgggagatta gatcgagact ctattaaagt ctaaatcgta tttataaacc 20580
gcataagaca ctaaaacctg gtgtgtgtgt gtgtgtgcgc gcatttgttt gcttgctcat 20640
gtttgtcctt gtgtgataaa tccatccctg ccctcaaatt gatttatgtg ttgtatgtgt 20700
tgattttagt gataacatct caaagtgatt aaatattttc aaaaatgcta tttgatgtct 20760
ataacggctt taaaactttt gcaagttcat tagagctatc tctagcacat atatggcgct 20820
tagagatgtt acgaatatgt aagactgatt acatatctct ttggcttaat aaatataagt 20880
atttgtgttg aactctttat cttcttcttg aagatgtctt atgggaaaca tgttaaatgg 20940
atagtaaatg agagattcga aaatatagtg tgagcttcct tctttggttt atgcattctc 21000
catgtggggg gcaaggtttt tgaagattta tacttttgtg gcaaatctct tgtttgaata 21060
ctccatggga gtctctcatc aaaactatgc tgcaaaatat ttgaaaattt ataaatctat 21120
tgtctttgag aaagtgttac aaaatttatg acctcaataa tattgcatga aaactttcat 21180
acatcatttg gtatatgtat gtttaagaaa aggtaaaacc gtaattataa agagaaagaa 21240
aatacaatat cttaatacat atcaatctaa ttactcatta accatattaa gaaaatatgt 21300
gtctttattt tttcctttta acataaagct taaaaagaag atttgtagcc agaaaaatta 21360
attgtgttca tttccctttt aaaagaattt ttcggcgcaa caaaatcgtg aaattgatat 21420
aaataaactc gagattatta atataaccct ttttcacttc acttctcttt ctctctaaac 21480
cctaaaagaa gaacgatgcc ggctccgacg acggagatcg aacccatcga agcacagtca 21540
ctgaaaaagc tcagtctcaa atccctcaaa cgatcacttg aactcttctc tcccgtccat 21600
ggccaattcc ctcctcctga cccggaagcg ttagtcttct tcgatcccca attttcgatt 21660
cgaatcttca ttttcttcac taagttttta tgatttcttc gttttttttt tttttttttg 21720
cagcaagcag attcgtctca gccataaggt aaaacattga gtctctctta ccagtcttta 21780
gaaatttatt tcagttattc gcttttaatg tctattgatt ggattttggt ttaaagcttc 21840
gaactttagg tttattcagg tttttccata attgttctaa atcttcaggt tttgttacca 21900
ataatagtaa agatggttga tttacttaga ctctctctct ctctctgttg tgtatgttac 21960
tgattttaga agttttcttt gtacagatga aagttgcgtt tggaggtgta gaacctgttg 22020
tgagtcaacc tccacgtcaa cctgaccgca tcaatgagca gccaggacct tcaaatgctc 22080
tttccctcgc aggtgttttt catatcacta tgtcttggtg aaagataaaa acttgtttct 22140
tgtttgctat ttgcattctt atttgtattg gaagggataa aatcatctgc ttgatgaatt 22200
ctgcagctcc tgaagggtct aagagtacgc aaaagggtgc gacagagagt gctattgttg 22260
ttggtccaac tttactgcgt ccaatactgc ctaaaggctt gtaagtgtta tcttttgttg 22320
ttggtttcgt tgatctgaat gctaattgat ggttctactt tatcgtgagg atgctcataa 22380
aagaattcgg ttctcgaatt gaaggaacta tacaggttcc tcagggaaga gcaccaccat 22440
tatacctgca aatgtatctt catatcaaag gtttttttct cgtcctcata cttgcttttc 22500
tttatctgga ttgcaataca ttaatggcag ctctaggtag tgtaggtagt tcatgggcat 22560
gcaaattaga cttcccccaa tctgaatttt tttggtttgt ccttataatg tagcttctaa 22620
ttctgattcc ttttttgttg ttgcgttcct ttgcgtgtta cagaaatctg tcaactgctg 22680
cattaatgga gagaatacca agtagatggc cccggccaga gtggcatgca ccatggaaga 22740
attacagggt aaaatccgtg gctcagcatt gttgctgcat catacggatt ttggtctttt 22800
gttggtctcc aaaaaactct ggtttgagga gttacttaac ttacgattaa ttattctttt 22860
cacaggtcat tcaggggcac ttgggttggg tcagatctgt tgcgtttgac ccgagtaatg 22920
aatggttttg tactggttca gctgatcgta ccatcaaggt agcagagatg attgcttatt 22980
caatatgaat tgtatttttt cgaatatgtt ttcttgttat acttataagt catgatacaa 23040
gacttccctt ctatggctag ttactggagc ttagtttagt gcattgccaa aaatccacta 23100
ctttggcgat tgtagaagca gttccgactt tggtatgttt actgaattta ttacttgtgt 23160
tttattcact agatatggga tgtagcaact ggagttctga agctaacact tactgggcat 23220
atcgagcaag tacgaggtta gcctttcaaa tctgttctcg tttattaata tttgttagac 23280
ttttcaataa ataacactct cgggacaagt tacaagtttg ggctcttttg ttttgaattt 23340
tgttacaggc ctcgctgtaa gcaatcgaca tacctatatg ttctctgctg gtgatgacaa 23400
gcaagtcaaa tgctgggacc ttgagcagaa taaggttaca actctattct cttcattatc 23460
tggatttctc atatctaatg ctcttggaat ttttgatttg ataggttatc cgatcttatc 23520
atggtcactt gagtggtgtc tattgcttag ctctgcaccc aactttggat gttttattaa 23580
ctggggggcg agactctgtc tgcagggtaa ggcaaaaata tttatatcca tatttatata 23640
tcttctcgtt tgaattcttg cactttgctg gatttgtagt ttaaaagtcc atgtttactt 23700
atttgcaggt gtgggatatt cgtaccaaga tgcaaatttt tgcactctca ggacatgaca 23760
acaccgtttg ttctgtattt actcgtccaa cagtaagtct cttttaatat ggacttgttg 23820
ttatggtttt tggatttctt gctgaatctt tttataatag taactggaac tcactttgat 23880
ctgtgttgtt gcaggaccca caagttgtca ccggatcc                         23918



<210> 537
<211> 1940
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein

<400> 537
atggaagcag caagaatggg ttttcgagct aaaactctcc ctcaccttgg caacggtact 60
cgacttcctc ttaagaccaa actctcgctc tttcctatgc atttgcttca aaaccacact 120
actctttccc ggagatcaac aaaactcaac ttatgtgtca aggcttgtag taagactagt 180
ggtgttgaga gtagtcgtcc cttgcctcac agtgctcccg atctttgggg agatcacatc 240
ctctctgtcc ccaccgaaaa ctcggaattt gatacactag agacagagat tgaatcaata 300
aagccgaaag tgagaaacat gctaatgtcg tctcacaaga ctgacaaaga gagaatatgt 360
ctcatacact tgcttatttg ccttggtact ttccattact ttgagaagga aattgaagag 420
attctagaac aggcttttcg gaagttggac atgctattta cagacgaaga tgatttggag 480
acaactgcca tcatgtttga ggttttcaga ttatatggac acaagatttc ttgtgatgtg 540
ttcgatagat tcaaaggtgt tgatgccaag ttcaaggaac atctagtcag tgatgttcgg 600
ggaatgctac agctgtacga agcagcgcat ctcgcaacac ccttcgaaac tatattggac 660
gaagccttga gtttcacaag gtatcacttg gaatctttgg ccggccaaca agctacagct 720
cctcatatct caagacatat acttaacgca ttgtataaac ctcggtttct taagatggaa 780
ataatagctg cccgggaata tattcatttc tatcaaaaag aaggtcatga tgagacattg 840
ctcaagtttg cgaagctcaa cttcaacttt tgccagctac attacgttag agagctaaaa 900
actctcacca aatggtggaa agacattgat cttccatata agctacctta catcagagac 960
aggcttctag agacctttat cggtgtcatg gcggtgtatc tcgagccaca ctattcactt 1020
gggagaatta tagccactaa agtttcccaa gtgatagtag ttatggatga cacctgtgat 1080
gcatatggaa ctttctctga agttagaagt cttattgatt ctttggaaag gtgggatcct 1140
ggtgccattg acaaactacc gagctgttta agaatcgtca tccaaagtat agttgaaaca 1200
atggaagata ttgaaagaga aatgaagccg cgaggaagat cctcgagtgt gcaagacacc 1260
gtagaagaga ttaagatcat ggggagagcg tacgctgaaa tatcaaaatg ggcacgagca 1320
ggtcacgttc caacctttga tgactatatt gagcttgggc ttgactcgtc agggattaga 1380
tgctttgcaa tgtacagctt tatatcgatg gaagattgtg aggagaatca aacgaacgcg 1440
tggttcaaat ccaaacccaa aatgttacga gctttaagtg ttatatttcg tcttacaaac 1500
gacatagccg gcttcgagga ggagatgagg agaggagaag tggttaatgg ggtgaactgt 1560
tacgttaagc aacataatgt taccaaggaa ttggcggttc gagaaattaa gaagatgatt 1620
agagataatt acaagataat gatggaagag ttcttgacga taaaaagtgt gtcacgtccg 1680
attctggtcc ggtgcttcaa cattgtacga ttggtcaatc tgtattacga ggagggtgat 1740
aatttcacca atcccaatgg caagctcaaa gatctcatca catctttgtt cttccatcct 1800
cttccgcttt gaagacttgg ctccttgccg aaaaattcat ctacatttct ctttccatta 1860
ttattgatga ttgttaattt gctctatgca catatttttc cattaaattt taattcctgg 1920
ggtttcaatt agtttttact                                             1940

<210> 538
<211> 1812
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein

<400> 538
atggaagcca taagagtttt tggaccaaaa cttggatcta gactctctat tcgttctcac 60
accactgcat ttccggcatg caaactctct cgctttccgc taacgtcatt tcccggtaag 120
catgcacatc ttgttctttt gaaggccact actattcctc tggcgtctgg tgacaaagaa 180
aataatcgca aattcgaaaa gttgggtcct tctgaatggg gcaatcaatt cctttttgct 240
catgttgatc tctcagaaat ggatgcgctt gagagagaga ttgaggcact aaagccgaaa 300
gtgagggaca tgttcatgtc tttcaaagga atgaagtcga acaagaagaa tttgtttttg 360
atatatttgc ttgtgagtct tggtctcgct catcatttcg aggatgagat cgaggagagt 420
gtcaaaggtt gttcccaaga gatggtggag atgatggacg gtgaaaatga tttgtacaca 480
gtttccatca tcttctgggt tttcaggaca tatggtcaca acatttcttc tgatattttt 540
aacagattta aaggacacaa tggaaagttt aaggaatgtc ttgccaccga tgctaagggt 600
atcctaagct tgtatgaagc tgctcacatg gggacgacaa ccgattatat attggatgaa 660
gccttgagct tcacattgag ttacttggag tcgttagctg caaatgggac atgcaaacct 720
aatctcgtga ggcgtatacg aaatgcattg ggtcttttgc agaacaagaa cgtggagata 780
ttagtcgcaa aggaatatat ccggttctac gaacaagaag aagattgcga taagactata 840
ctcgagtttt ccatgcttaa cctcaaattc ctacagctac attaccttca agaactcaaa 900
cttcttacaa aatggtacaa ggaacaagac tttgaatcca agttgccacc ttactacaga 960
gacagaatcg tggaactgca cctcgctacg ctagcataca tcaatccgaa atactcacgt 1020
gtgaggatta ttctgactat gatttacact attcaaataa ttctagatga tacgtgtgac 1080
agatatgctt ctcttcgtga ggtcgaaagc ctcgctgcaa ccatcgaaag atgggatcac 1140
aatgatcatg ccatggaggg actaccggat tatttaaaat ctgtggccaa atttatattt 1200
cataccttcc aagagtttga aagagaagtg tcgtcagaat caggaggatc ttacagcttg 1260
aaagctacaa ttgaagattg caagagaatg atgagaagca accttcaact tgccaaatgg 1320
gcagtaacgg gtcacttgcc tagctttgat gagtacctag atgtcgctgg agtcgagatc 1380
gccgtatatt ttaccgtggc aggtattttg ttgggcatgg aaaatatcaa caagaaagaa 1440
gcttatgagt ggttgatatt tagagacaaa ctcgtaagag caatgtctac aaaagcacga 1500
ctggtgaatg atttgtttgg ctataaggat gacatgagga gaggatatgt cacgaactcg 1560
atcaactgtt ataagaagca atatggagtt accgaagaag aagcctttag aaagcttcat 1620
caaatggttg cggacggtga taagatgatg aatgaggagt ttttgaagcc aatcaatgtg 1680
ccacatcagg ttctaaaagc agtcctcgac actttacgtg caattaacat ttgctacgac 1740
aatgaagatg gatttacccg actcaatggt aatctgaaga actacatcac gtctatgtac 1800
gttgatcttt ga                                                     1812

<210> 539
<211> 1806
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein

<400> 539
atggaagcaa caagaacgag ttttggtctt cataacgccc ctctctgccc cacaacaaac 60
ccctctcttt ttcctcggcg ttggcttcac aagcacactc tttccttgaa accggcaaaa 120
caacaccact tggtctgcgt tagggctact gagagtaatg ataatcttga aagtagtcgt 180
cccttggcac acttttctcc cactctttgg ggagatcact tcctttctgt tcccctccat 240
gtcgctgaat ttgatgattt ctcaagagag attgaagtga cgatgaagcc aaaagtgaga 300
gacatgctca agtcttccaa aaacagcgac aatgagagga tccgtctcat ccatttgcta 360
atgaacctcg gaatcgcata tcatttcgag attgagattg atgagattct tggccaagct 420
tttgggaatt tggacgatat aatagccaag gaaaatgatt tggaaacaat ctccaccatg 480
tttgaggttt tcagactacg cggttactat atgccttgct atgcattcaa tagattcaaa 540
ggtgaagatg ggaggttcaa ggaaagtcta gctgaggata ttagaggaat gctacagttg 600
tacgaagcag cacatctcgg gacaccatct gaagatatta tggacgaagc attgagcttc 660
actcggtatc gcttagagtc gttgacaagt aatcacacag caactgctag tccccatctc 720
tctaaacata tacaaaacgc actatataga gctcgatatc ataacttgga gatattagtc 780
gcaagagaat atatctcttt ctacgaacaa gaagaagatc atgacgagac gctgctcaag 840
tttgcaaaac tcaacttcaa ctattgccag ctacattata tccaagagct aaaagatctg 900
accaaatggt ggaaggagct agatcttgca tctaagctgc cttacatcag ggacagaatt 960
gtagaggtct actttggggc actcgcattg tattttgagc cacggtattc actagggaga 1020
attatagtca ctaaaattac catgattgtg actgttttta atgatacatg tgatgcatat 1080
ggtactcttc ctgaagttac aagcctcgtt gattctttcc aaaggtggga tcttggggac 1140
atagaaaagc taccaagtta tgtaaaaatc gtctttcgag gtgtatttga aactttagaa 1200
gagattgaac aagaaatgag gccacaggga aggtcacgca ttgtgcaagt agcggtagat 1260
gagatcaaga agttggggaa agcatacttg gctatctcga aatgggcacg cgcaagtcac 1320
gtgccaacct ttgaggagta catggagttt ggtatgcaga cgtcaatgga tcattttgca 1380
gcctatagct ttatcgcgat ggaagattgt gatgagaatc aaacgtgcga gtggtacaaa 1440
tccagaccta aaatgatgga agctctgaat ggtgtgtttc gtattaagaa cgacataaac 1500
acctttgagc aagagatgag cagaggagaa gtggctaaag ggctgaattg ttacatgaag 1560
caacatggtg tttccaaaga agaggcgatt ggagagatga acaagattta tagtaattat 1620
tacaaaataa taatggagga gtacttgacg acaaccgctg tgccacgtcc gattctggtg 1680
cgatgcctca acgtttcacg acccatccat catttttaca aggagagaga tgaattcaca 1740
gatccttatt tcggaatgct taaagaagtc atcacttctt tgttcatcca tccaattcct 1800
ctttga                                                            1806

<210> 540
<211> 1815
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein

<400> 540
atggcagtag caagaacggt ttttgggctc ggaactctct cttaccttca ccaagctcct 60
ctctttctta agaccagtca atctctcttt cctcgccctt ctctttctct gaaacctatg 120
aagcacgact ttgtatgtgt taaggctact actaagagtt cgactagtga tgatcttgag 180
agtggtcgtc cttcgatact cttttctccc tccatttggg gagattactt cctctcagtt 240
tcggttgacg attccgaatt tgatgacata gcgagagaga ttgaatccgt gatgaagcca 300
tacgtgagag acaggctcat ctcttctcac aacagcaaca aggacaagat tcgtttaatc 360
catttgctta tcagccttgg catctcgtat tacttcgaga gcgaaattga gatgatccta 420
aacaaggctt ttgaagagct ggacatgata atagccgagg aagacgattt ggaaacaatc 480
tccatcatgt ttgaggtttt ccgactatat caacacaaga tgtcatgcga tagcttcgta 540
agattcaagg gtgaagatgg gaggctcaag gagagtctag tcggggatgt tagaggaatg 600
ctacaattat accaagcagc gcatcttggg acaccctctg atcaatatat aatggaggaa 660
gccaagagtt tcactaggaa ccacttggag tctttggtag agagtactac tattcctcca 720
catttctcct cacatattcg tgacgccttg tacatagatc gatatcataa catggaaata 780
ctagtcgcaa ggaaatacat ctctttctac gaacaagaag aaggtcatga tctgacgctt 840
ctcaagtttg gaaagctcag cttcaattat tgtcgtttac attacatcca agagctcaaa 900
actctcacca aatggtggaa agatcaagat attccctcta accttccttg cgtgagggat 960
agaattgtgg agacctattt ccctacattg ggactatatt tcgagccacg attttcactt 1020
gggagaatta taatagctaa aatgaccatc atcgtggttg ctttgaatga cgtgtgtgat 1080
tcatatgcaa cttaccccga agctaaaagt ctcatagact ctttgcaaag gtgggatatt 1140
gaagcgattg acgaactacc aaactattcg agaatagtcc tccgattaat attggaaact 1200
ataggagaga ttgaaagaga aatgaagccc cgaggaagat ctgctagtgt acaacacacg 1260
atagatgaga ctaagagctt agggagagcg tacctagcat tatcaaaatg ggcaagtgaa 1320
ggctatatgc caacctttga tgagtacatg gaggttgggg aggtcactgg ggggatggat 1380
gattttgctt tgtacagctt tatcgcgatg gaagattgcg acgagaaacc attgtacgaa 1440
tggtttgact ccaagccaaa aatattacaa gctttgagtg ttctatatcg tataaacaac 1500
gacatagtca cctacgagag agagatgagc aaaggagagg tcgtgaatgg ggtaaactct 1560
tacatgaatc aacacggtgt tactaaagaa gaagcggttg aagaattgag aaagatggct 1620
agagataact ataaaatagt catggaggag ttgttgacga tcactgatgt gccacgacca 1680
gttttggtgc gatgcctcaa tcttgcacgc ttgttcgatg tgttttgcaa gcatggtaat 1740
gatgaattca cctatccgca tggaaatctc aaagatctca tcacctctat attcatccat 1800
cccattcctg tttga                                                  1815

<210> 541
<211> 1803
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein

<400> 541
atggaagcca taaaaacttt ttcaccaaaa tttggattcc aaatctctct ttctcctcgt 60
acccatttaa ctccagtcag atttccaccg acagcatgtc cagttaagcc tgctaatctt 120
gtccgtttga aggcaactag agctctgatt cgtgatcctc aagaaagtaa ccgtaagttc 180
caaaagttcc caccttctga atggactaat cgcttcgact ctgtctcggt agatgcatcg 240
gaaatggatg cgcttaggaa agagatcgat aagattatac cgaacgtgaa gaaggaactc 300
atgtcttccc aaggcattga atcgacgaag aaaaaaatcc ttatggtata tttgctggtt 360
agccttggtc ttgcttatca cttcgaagat gagattgaag agtgtctgaa agagggtttc 420
gaaacaatag aagagatgat ggctggtgaa gataatttgt atactatttc aatcatcttt 480
ttggttttaa ggacatacgg tcaccatatg tcatccgaca tatttcagaa attcaaagga 540
aacgatggaa attttaaagg atgcattagt ggggacgcta agggtttgtt ggccttgtat 600
gaagccgcgc aattgagaac gactacagag tatataatgg aagaagcact gagcttcaca 660
tcgagcaatt tggagttgtt agctgcagat gggaggtgcc cacctcatct ctcaaaacat 720
atacgaaatg ctctaggact atctcagcat aaacagatgg aggtgttagt agctgtggaa 780
tatatctcat tctatgaaca agaaaaagat cacgacaaaa tactgctaaa atttgcgaag 840
ctcaatttca agttaatgca gctccattac cttgaagagc tcaaggtcgt tacaaaatgg 900
tacaaggaac acgattttgc atctaacttg ccaccttact tcaaatacgt aatcgtggag 960
aatcatttct ttgcaataac gatgtacttc gagccaaaat tctcacaaaa gcggattatg 1020
ctggctaagt actttacggt tttagtactt ctagatgaca cttgtgatag atacgcatct 1080
ctttctgagg ccgaaagcct caccaatagt ctggagaggt gggctcctga tgatgctatg 1140
gataaacagc cacattattt gaaattcgtg tttaagttta taatgggttg cttcgaagag 1200
tttgaaagag aattggcgtc agaaggaaga tcttactctg tgaaagccac actagaagag 1260
tttaagacaa ttgtgaaagc caactttgat tttgcaaaat tggcacacac gggtcacgtg 1320
cctagtttta aggagtacat ggaagttggt gaggtggagg ttggggtatg tgcgactttg 1380
gcaggcaatc tgatgtgtat cggacatatc ggtgatgagg gagtttatga gtggctcaaa 1440
tccagaccaa aatttctcaa agcagcctct acatatgggc gtctgatgaa tgatatagcc 1500
ggatttgagg atgacatgaa aagagaatat gtcattacgg gagtcaacac ttatatgaag 1560
caatatggtc taaccaaaat ggaagctatc agagagcttc aaaacttagt tgaatacaac 1620
catacgataa tgaacgaaga gtttttgaag acaactgatt taccacgcca aattcggaaa 1680
caagtcatca acgttgcacg ctctctcaac gtctcctata ctgaaggtga aggatttacc 1740
cataccaaag gaaaagtcga tgagtatatc acttctttgt ttattacccc gattcgtatt 1800
tga                                                               1803

<210> 542
<211> 1699
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase/cyclase family protein

<400> 542
accaacacca catctctctc tatctatgga agcattagga aactttgatt acgaaagcta 60
caccaatttt acaaaattgc catcctccca atggggtgat cagttcctca agttttccat 120
tgctgattcg gattttgatg tccttgaaag agagattgaa gtactaaagc ctaaagtaag 180
agagaacata ttcgtgtcgt cttccacaga caaagacgcg atgaaaaaga caattctttc 240
tattcatttt ctggacagtc ttggtctctc ttatcatttt gagaaggaaa tcgaagagag 300
cctaaaacat gctttcgaga agatagaaga tttgatcgct gatgaaaata aattgcacac 360
aatctccacc atcttccgag ttttcaggac atacggttac tacatgtctt cggatgtttt 420
caagatattc aaaggagacg atggtaaatt caaggaaagt ttaatagaag atgtcaaggg 480
tatgctaagc ttctacgaag cagtgcactt tgggacaacg acagatcata tattggatga 540
agctttaagc ttcacattga accacttgga gtcactagct acaggtcgta gagcgagccc 600
accacatatt tcaaagctta tacaaaatgc tcttcacata cctcagcacc gaaacatcca 660
agcgttggtt gcaagggagt atatctcgtt ctatgaacac gaagaggacc acgacgaaac 720
acttctcaag ctagctaagc tcaatttcaa gttcttgcag cttcattact tccaagaatt 780
aaaaaccatc acaatgtggt ggacgaaatt agaccataca tcaaaccttc caccaaactt 840
cagagagaga actgtagaga catggtttgc agcattgatg atgtacttcg agccacaatt 900
ttcacttggg agaattatgt cggctaagtt atacttagta ataacatttc tagacgacgc 960
ttgcgatact tatggttcaa tttctgaagt tgaaagcctg gccgattgtt tggaaagatg 1020
ggatccagat tacatggaaa atcttcaagg tcacatgaag actgccttca aatttgtgat 1080
gtatcttttt aaagagtatg aagaaatact aaggtcacaa ggaagatcct ttgtgttgga 1140
gaaaatgata gaagagttca agattattgc taggaaaaac ctcgaacttg tcaaatgggc 1200
acgtggaggt catgttccta gctttgatga gtatatagag tctggtggag ccgagattgg 1260
tacatatgca accatagcat gttccatcat gggacttgga gagattggta agaaggaagc 1320
ttttgagtgg ctaatatcta gaccaaagct cgttcggatt ttaggtgcaa agacccgtct 1380
catggatgac atagccgact ttgaggagga catggaaaaa ggttacactg caaatgcact 1440
caactattac atgaacgaac acggagttac aaaagaagaa gccagtagag aacttgaaaa 1500
gatgaatgga gatatgaaca agatcgtaaa cgaagaatgc ttgaagataa ctaccatgcc 1560
acgccgaatt cttatgcaat ccgtcaatta tgcacgttca ttggatgttc tctataccgc 1620
ggatgatgtt tacaaccacc gcgaaggaaa actcaaagag tatatgaggc ttttgctcgt 1680
agatcctata cttctttag                                              1699

<210> 543
<211> 1644
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> beta-caryophyllene/alpha-humulene synthase

<400> 543
atggggagtg aagtcaaccg tccactagct gattttccag caaatatctg ggaagatcca 60
ttaacttctt tctcaaagtc tgacctcgga actgagacgt tcaaagagaa gcatagtacg 120
ctaaaggagg cggtgaagga agcttttatg tcttccaaag cgaatccgat agagaacatc 180
aaattcatcg atgctctatg tcgccttggt gtctcctgtc actttgagaa agatatcgta 240
gaacaattgg ataagtcatt tgattgtctt gattttcctc agatggtaag acaagaggga 300
tgcgatttgt acacggttgg aataattttc caagttttca ggcaattcgg ctttaaactt 360
tctgccgatg tgtttgagaa gttcaaggac gaaaatggga agttcaaagg acacttggtg 420
acagatgcat acgggatgtt aagtttgtac gaagctgcac aatggggcac tcacggagag 480
gacattattg acgaagctct cgctttctca cgttctcatt tagaagaaat ttcgtctcgg 540
tctagccctc atctcgcaat tcgcatcaag aatgctctaa aacatccata ccataaaggc 600
atctctagga tagaaacaag acaatatatc tcatactacg aggaggaaga gtcgtgcgac 660
ccaacattac ttgagttcgc aaagatagat tttaatttgc tgcaaatatt acaccgcgaa 720
gagcttgctt gcgtcacaag gtggcaccat gaaatggagt ttaaatctaa agtaacatac 780
acaaggcata ggataacaga ggcatacttg tggtcacttg gaacatattt cgagcctcaa 840
tattctcaag cacgagttat aaccactatg gcactaatct tattcacagc gcttgatgat 900
atgtatgatg catatggcac aatggaggaa cttgagcttt tcactgatgc aatggatgag 960
tggcttcccg ttgttcctga tgagataccg atacccgata gcatgaagtt catttacaat 1020
gtgacggtag aattctatga taaactcgac gaggaacttg agaaggaagg aaggtcaggg 1080
tgcggtttcc atcttaagaa atcattgcaa aaaacagcaa atggatatat gcaagaagca 1140
aaatggttga aaaaggatta cattgctaca tttgatgagt ataaagagaa tgcaatcttg 1200
tcttcaggtt attatggctt gatagcgatg acattcgtga gaatgacaga tgtcgcaaaa 1260
cttgatgctt ttgaatggtt aaactcacat cctaaaatta gggtagcttc tgagataata 1320
agtcgattca cagatgacat ttcaagctac gaatttgaac acaaacggga gcatgtagcg 1380
actggcattg attgttatat gcagcaattt ggtgtttcca aggaaagagc tgtggaagtg 1440
atgggaaaca ttgtttcaga tgcatggaag gacttgaacc aagagctaat gaggcctcac 1500
gtgtttcctt tccctctttt gatgcgagtt cttaaccttt cgcgagtcat cgatgtattc 1560
tataggtacc aagatgctta caccaacccc aagctcttga aggagcacat tgtttctttg 1620
ctcattgaaa ctatacccat ttga                                        1644

<210> 544
<211> 1818
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase

<400> 544
atggaagcca catcagtttt taggccaaaa cttggatctc agttttctct tccttctacg 60
accaatttat ttccgttaag aaaactctat ggctttcctc tgacgtcatt tcccggtaag 120
cctataaagc gtattcgttt gaaggcctct aatactctga catttgatga taaagaacgt 180
actcgtaagt tcaagaaatt accactttct gaatggactc actacttcca ctcgattccc 240
cttgatatct cggaaatgga tgcacttaaa gaagagatcg atgaactaaa gccgaaagtt 300
aaaaacacat tcatgtcttc ccaaggcagt gactctacaa agacgaaaat ccttatgata 360
tatttgtttg tgagccttgg ccttgcatat cacttcgagg aagagatata tgagactcta 420
aaagagggtt tcgaaaatat agagaagatc atggccggtg aagaagattt gtacacagtt 480
tcgatcatct tttgggtttt cagaagatat ggtcactaca tatcttcaga tgtattccaa 540
agattcaaag ggagcaatgg aagttttaaa gagtctctta tcggagacgc caagggtatg 600
ttgagcttgt atgaagctgc acatttggcg acaacaaaag attacatatt ggacgaagca 660
ttgatcttta catcgagcca cctggagaca ttagttgcaa ctggaacgtg cccacctcat 720
ctcttagcgc gtatacgaaa tgctcttagc atctgtcagc attggaactt tgaggtatta 780
gtcccactgg atttcatacc attctatgaa caagaaaaag accatgacga gatgctactc 840
aaatttgcta agctcagttt caagtatctg aagctcatat accttcagga tctcaaaatc 900
cttacaaaat ggtacaagaa gctagatttt ccatctaagt ttccacctta cttcaaagac 960
agatgcgtcg aaaattattt ctttgtgtta ccggtgttct tcgaaccaca actctcaagt 1020
gcaaggatgt tgttgactaa gggcttcatc cttctgggga ttcaggatga cacattcgac 1080
agatatgcat ctatttctga ggccgaaagc ctcggcaaca gcttgaaaag gtgggctcca 1140
gatcattcca tggacaaaca acctgaatat ttgaaatccg tattgaaggt tatattagat 1200
actttccaag agtttgaaaa agaacttagc cccgaaggaa gatcttacag tgtgaaatac 1260
acaattgaag agttccaggc atcttcgaaa gctaacgttg agttggcaaa atgggcacaa 1320
gtgtctcacg tacctagctt tgagaaatac atggaagttg gacagatgga aatcaccgca 1380
tgtgtgaccg ttgcatatat tttaatgtct atgggaaaga cggatagtaa ggaagctttt 1440
gagtggctaa aatccagacc aaaactcgtc caatctttat gtactaaagg tcgtcttatg 1500
aatgatatag ccggttttga ggatgacatg agtagaggat atgtcgtgaa tgctgtcaat 1560
tgttatatga agcaatacgg agttactgaa aaggaagctt ttaaggagat tcgtaaaatg 1620
gttgtaaata cacataagac attaaatgag gagttcttga caaccacttg cgtgccacat 1680
tatgttctta gggaaaccat ggattttgca cgcatgatca tcgtcaccta caatggatat 1740
gaaggattta cccgtcctga tgaaggaata atcaaggagt atatgacttc gttattcgtc 1800
gatcagatcg atctttga                                               1818

<210> 545
<211> 1812
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase

<400> 545
atggaagcat caaaatgttt tggtccaaga actctcccta tcattcacaa cgtccctctc 60
tgtctgaaga ccaacttctc tctctttcct cgctgtttgc ttcaaagcca atctctttcc 120
tccaagaaat ccacaaaaca cgacttgttc cgtgttaagg ctgagactag tggcgatctt 180
gagaatactc gtccattgac gtactattct ccatctcttt ggggagatca cttcctctct 240
gttcccatcg atgaatccaa atttgaggca cttgagaaag aaattgaatc ggtgttcaag 300
cctaaagtga gagacatgct catgtctcct cacagcagcg acaaggagag gattcgtctc 360
atccatttgc ttatcagcct cggtatcgct tattactatg agaatgaaat cgaggagatt 420
ttacacaagg cttacgggaa gttggcctgc ttaatttcgg acgaggatga tttggaaaca 480
atagcaatca tgtttgaggt tttcagacta tatggacaca agatgccttg cgatgtgttc 540
gagagattca aaagcgaaga tgggaagttt aaggaaagtt tagttgggga tgttagaggg 600
ctgctacaga tgtacgaagc cgcgcatcta ggagcaccat ctgaagatat aatggatgaa 660
gccttgagtt ttgcgcggta tcacttggaa tcgttggtaa gccacgaaac aagctccaat 720
ctctttaatc atgtacaaaa cgaattgtat agagctcgat atcatagcat agagatacta 780
gtagcacggc agtacatctc tttctatgaa caagaagaag accatgatga gacgctcctc 840
aggttttcaa agctcaactt caatttttgc cagatgcatt acgtcaaaga cctcaaaatt 900
gtcaccagat ggtggaagga gctaggtatc gcatctaagc taccctactc tataagggaa 960
cgaaatgtgg aggtctatct tgggagcttg ggaatgtttt tcgagccacg gtattcactt 1020
gccagaattt tttcggccaa gcttacaatg atcttgactg ttgttgatga tacatgcgat 1080
tcatatgcca ctcttcctga agttaagagt cttcatgatg cttttcatag atgggatctg 1140
cgtgccatgg aagaactacc gaggtatatg agaatcatct accaaagtgt gttcgagact 1200
gtggaagata ttgatcgaga aatgatagct cgaggaaaac atggtcggtt gcaactaacc 1260
atagatgaga ttaagagtct aatgatatgg tatcttggga tagcaaaatg ggcacgctca 1320
gatcaagtgc caagctttga ggattacatg gagattggga ccccctcgtc tgcattggat 1380
gacttagcat catacggctt tatagcaatg gacgattgtg atcagaagaa attgaaggag 1440
tggttttact ccaaacctaa aatctttcat gccttgaatg ctctgtttcg tatcagaaat 1500
gacattgtca cgttcgagca agagatgagc agaggagagg tggcaaatgg tgtcaattgt 1560
tacatgaagc aacatggtgt caccaaagaa gcagcggttg aagaactgag gaagatggaa 1620
agagagaatt ataagataat gattgaggag ttcatgacgt ccaaagctat gccacgccag 1680
attctggtgc gacccgtcaa cattgcgcgt gtgatggatt tgtattacaa agaagccgat 1740
ggatttgggc atcctgatca aaagctctta caacttattg cgtctttgtt cctccatcca 1800
atacctcttt ga                                                     1812

<210> 546
<211> 1818
<212> DNA
<213> Arabidopsis thaliana

<220> 
<223> terpene synthase

<400> 546
atggacgcaa caagaacgtt ttttggtctt cctaacgttc acaacgttcc tctctgtctc 60
acgtccaacc tctctctctt tcctcagcgt ttgcttcaaa agcacactct tcccctgaaa 120
ccggtaaaga gacaccactt ggtatgtgta aggtctacaa agagtagtga tgatcttgag 180
ggtagtcgtc cttcaacgta cttttctccc tctctttggg gagatcactt cctctctgtt 240
tccctcgacc gcggtgaatt tgatgaacta gaaagagaga ttgaaactat gaagccactg 300
gtgaaagaca tgctcatgtc ttctcaaagc agcgacaagg agaagattcg tctcatccat 360
ttgctcgtta gcctcgggag ctcttatcat tttgataagg agattcaaga tatccttaaa 420
cacagtttca caaagttgga tgacataata gttggggaag atgatttgga aacaatctcc 480
atcatgtttg aggtctttag actatacggt cacaagatgt cttgtgatgc ctttgataga 540
ttcagaggtg aagatgggag gttcaaggag agtctagcca aagatgttag aggaatgcta 600
cagttgttcg aagtcgcgca tctaggaaca ccctctgaag atataatgga cgaagcatcg 660
agtttcgccc agaatcactt ggagtcttgg atagctggta acgtatccgg tgcaactccc 720
catctcttga agcatataca aaactcatta tacatacctc gatactgtaa catagaagta 780
ctagtggcaa gagaatatat atcttactac gaacaagaag aaggttacga cgagatcctg 840
ctaaagtttg caaagcttaa cttcaacctt tgccagtttc gttacatcca agaactcaaa 900
actctgacca aatggtggaa ggacctagat cttgcatcta agttacctta catcagggat 960
agacttgtag agagccatct cgggggtttg ggaccgtact tcgagccaca ctattctctt 1020
gggaggatca tagtggctaa aatcatcatg accatggttg ttgtggatga cacttatgat 1080
gcacatgcaa ctgtacccga agttgcggtg cttacggaat gtttgcagag gttgaatatt 1140
ggtgccgatg ataaactacc agactatttg agaatcgtcc tcgaaagtgt gtttgaagtt 1200
atgggagaga ttgaacaaga aatgagaccg aaaggaagat catacggcgt gaaacaagtg 1260
ttggaaaggt tcaagaacgt agcaaaggcg gacaaacagt taacagagtg ggcacgaacg 1320
ggccacgtac catcctttga tgagtacatg aaagttgggt tggtgacagc tgggatggat 1380
ggttatgcag gatattgctt tataggaatg gaagatatca gtgagaagga agcttttgag 1440
tggctgagtt ccaatcccct aatcatccaa gcgctaaatg taatgttccg tttagcaaat 1500
gacgtaggaa cctacgagac cgagataaac agaggagagg tggctaatgg gctcaactgt 1560
tacatgaaac aatatggagt caccaaagaa gaagcatccc aagagttgcg taaaatatac 1620
agcaacaaca aaaaagtggt tatggaggag ttcatgaact cacatgacca tgtgccacgc 1680
caggttctgc tgcgatgcct caactttgca cgcctcttcg atgtgatgta cacggagggt 1740
gatggataca gtgaacccaa aggcaaaatc gaacacttta tgacctcctt gtacgtccac 1800
ccaatacccc tttcataa                                               1818

<210> 547
<211> 1863
<212> DNA
<213> Artemisia annua

<220> 
<223> (-)-beta-pinene synthase

<400> 547
atggcttcaa tgtgcacatt ttcttctcca tttctcttat gtaatagttc cataagtaga 60
acaaatattg ttgcatgtaa caagcaaaca tctacactac aagcccaagt taaaaatgtt 120
gctacaattg aaaccaccaa cagaagatca gctaattatg ccccttcatt atggtcctat 180
gattttgtcc agtcgctttc tagcaaatac aaaggagata actatatggc aagatcacga 240
gctctaaaag gagtagtgag gaccatgatt ttagaagcga atggaattga aaatccattg 300
agtttactta atttggtcga tgatttgcaa agacttggaa tatcatatca ttttttggat 360
gaaataagca atgttttgga gaaaatatac ttaaatttct acaaaagtcc tgaaaagtgg 420
actaatatgg atttaaatct tagatccctt ggttttagac tcttgagaca acatggatat 480
catattcctc aagagatatt caaggacttt atagacgtga atggaaattt caagggagat 540
atcatcagca tgctaaattt gtatgaagct tcttatcatt cagtagagga ggaaagtata 600
ttggatgatg ctagagagtt cacaacaaaa tatttgaaag aaactttaga gaatattgaa 660
gatcaaaata tagcgttgtt cataagtcat gcattggttt ttccacttca ttggatggtt 720
ccacgggtgg aaacaagttg gtttattgaa gtttatccga aaaaagttgg catgaatccc 780
acggtgcttg agtttgcgaa actggacttc aacatactgc aggcagttca ccaagaagat 840
atgaaaaaag catcaagatg gtggaaagaa acatgctggg agaagtttgg ctttgctcgt 900
gatcgtttgg tggagaactt catgtggact gttgccgaaa attacttgcc tcattttcaa 960
acaggaaggg gagttctcac aaaggttaac gccatgataa ccactatcga cgatgtttat 1020
gatgtgtatg gtactttgcc tgaactcgaa ctatttacca acattgtaaa cagttgggat 1080
atcaatgcga ttgatgaact tccggattat ttgaaaatat gcttccttgc gtgctacaat 1140
gctaccaatg aattatcata taacacattg acaaacaaag gattcttcgt acatccttac 1200
cttaaaaagg cgtggcagga tttatgcaac tcttacataa ttgaagctaa atggttcaat 1260
gatggataca caccaacctt caacgagttc attgaaaatg catacatgtc aataggaatt 1320
gctccgatca tcaggcatgc ctatttgtta acattaacta gtgttaccga agaagcattg 1380
caacacatag aaagagctga aagtatgatt cgcaatgcat gcctaattgt gcgactcact 1440
aatgatatgg gcacatcatc tgatgagctt gaaagaggtg atattccaaa atcaatccag 1500
tgctatatgc acgaaagtgg tgctactgaa atggaagcac gagcgtatat aaaacagttc 1560
atcgtcgaga catggaagaa actgaacaaa gaacggcaag aaattggttc tgaatttccg 1620
caagagttcg ttgattgtgt tataaacctt cctagaatgg gtcatttcat gtataccgat 1680
ggagacaaac atggtaaacc cgacatgttc aagccgtatg tattttcatt gtttgttaat 1740
ccaatctagg gggtacccta aaattttcaa cttgtaactt aataaaccta tctcgttata 1800
tgttgtcaag attattctta ttggctcatt aatcttgtta taatgaaaaa aaaaaaaaaa 1860
aaa                                                               1863

<210> 548
<211> 1769
<212> DNA
<213> Artemisia annua

<220> 
<223> (3R)-linalool synthase

<400> 548
ggtaatgctt acatgcgaat atattcaaca aaaaccacaa gaataactgc caatgcaact 60
gtcaatgcag ctgacaccca cgtaaggcga tcagcaaatt acaaaccatc atcatggtca 120
tttgatcata ttcagtcact ctctagtaaa tacacgggag atgattacgt ggcaagagca 180
aatactttga aggacgcagt gaagacgatg atacgaaaat caggaaattc gttgagaact 240
ctggagctag ttgatgagtt gcaaagatta ggaatctcgt atctttttga ggaggaaata 300
agtaatctct tggaaacgat ttactacaat tactataaat ttcctgaaaa ttggaataag 360
atcaatttga accttaaggc tcttggcttt cgattactga gacaacatgg ttatcatgtt 420
cctcaagaga tatttctcaa ctttaaggac aagaatcaaa atcttaattc atatttactc 480
aacgatgttg tggaaatgct caacctgtat gaggcatctt atcattcgtt cgaggatgaa 540
agcatattgg acgacgctag agacatcaca accaaatatc tcaaagaaag cttggagaag 600
attgacggga gtatcttttc atcagtaact catgctttgg agcaaccgct gcattggagg 660
gtaccgagag ttgaggcgaa gtggtttatt gaactatatg agaaaaagaa tggcatgagt 720
cccacattag tcgagcttgc gaaattggat ttcgatatgg tccaggctat ccatcttgag 780
gatctaaaac acgcatcaag gtggtggaga gatacaagtt gggataccaa gttaaccttt 840
gcaagggact tgatagtgga gaatttcttg tggacaattg gtttcagtta cttaccaaac 900
tttagtcgtg ggaggagaac aataactaag gtggccgtta tgattactac tctcgatgat 960
gtctatgatg tgtttggtac tttgggcgaa ctagaacaat tcactgatgt tataaacaga 1020
tgggatataa aggcgattga acaactccca gattatatga agatatgttt cttaggactt 1080
tacaagtcga taaatgatat cacgcatgaa actttggcaa acaaaggatt cctcattctt 1140
ccatatttaa agaaagcatg ggcagatcta tgtaaggcgt acctagtaga agctcaatgg 1200
taccaccgtg gacatatacc aacactgaac gagtacttgg acaatgcttg tgtatcgata 1260
tcaggacctg tagcacttat gcatgtccac tttttaacat cagttagttc aatcgaagaa 1320
atccatcaat gcatacaaag aactgagaat atagttcact atgtatcact tatcttccga 1380
cttgctgatg acttggggac atcattaggt gaaatggaaa gaggtgatac tctaaaatca 1440
atccagttgc acatgcatga gaccggtgct actgaaccag aagctagaag ttatataaaa 1500
ttgttaatca acaaaacatg gaagaaactt aacaaagaac gagcaactgt taactccgaa 1560
tcttcacagg agtttattga ttatgcaaca aaccttgtta gaatggctca attcatgtac 1620
ggtgaaggag acgaggattt tggtctagat gtgattaaat ctcatgtatt atcattgttg 1680
tttactccaa tccaagggat ataaatatgt aacacgatgg tatatatacg tgaataagaa 1740
gctaaggaga tcttagtatt cttgtcttc                                   1769

<210> 549
<211> 1725
<212> DNA
<213> Artemisia annua

<220> 
<223> (E)-beta-farnesene synthase

<400> 549
atgtcgactc ttcctatttc tagtgtttca ttctcttcat ctacgtcacc tttggttgtt 60
gacgataaag ttagcacgaa accagatgtt atccgccata ccatgaattt caatgctagc 120
atatggggag atcaatttct tacatatgat gagccagaag atttggttat gaagaaacaa 180
cttgttgaag agctcaaaga ggaagtcaag aaagagctaa taacgatcaa aggttcaaat 240
gaaccgatgc agcatgtcaa gttgatagaa cttattgatg cagtccaacg gcttggcata 300
gcctatcatt ttgaagagga gattgaagaa gccttgcaac atatccatgt tacatatggc 360
gagcagtggg tcgataaaga aaacctacaa agcatttctc tttggttccg actcctacga 420
caacaaggct tcaacgtctc atcaggagta ttcaaggact ttatggacga gaagggaaaa 480
tttaaggaat ccttatgtaa tgatgctcag ggaattcttg ctctgtatga agcggcattt 540
atgagggtgg aagatgaaac aatactagat aatgcgctcg agttcactaa agttcacctt 600
gacatcatag ccaaggatcc ttcttgtgac tcttccctaa gaacccaaat acaccaagcg 660
ttaaagcagc cacttaggag aaggctggca aggattgagg cgttgcatta catgcctatc 720
taccaacaag aaacatccca cgatgaggtc ttactgaagc ttgcaaaatt agattttagc 780
gtgcttcagt cgatgcacaa aaaggaactt agccacattt gcaaatggtg gaaggatttg 840
gacctccaaa ataagcttcc ttatgttcga gacagggtgg tggaaggcta tttttggata 900
ctatccatct attacgagcc tcaacatgct cgaacaagaa tgttcctaat gaaaacatgc 960
atgtggttag tcgttttaga tgatacattt gataattatg gtacttatga agaactcgaa 1020
atctttacac aagctgttga aagatggtca ataagctgcc tggatatgct tccagaatac 1080
atgaaactaa tatatcaaga gcttgtgaat cttcacgtgg aaatggagga atcacttgaa 1140
aaggagggaa aaacatatca aattcactat gtcaaggaga tggcaaaaga gttggttcgc 1200
aattacttgg tagaagccag atggctaaaa gaggggtaca tgccaactct tgaggagtac 1260
atgtctgtgt caatggtgac tggtacctat ggcttgatga tagcgagatc ttatgtcggc 1320
aggggtgata tcgtcaccga ggataccttt aaatgggtgt cctcgtatcc tcctattata 1380
aaagcttcat gtgtgattgt aagacttatg gatgatattg tcagccacaa ggaggaacaa 1440
gagagaggcc atgttgcttc aagcatcgaa tgctattcta aggaaagtgg tgcatcagag 1500
gaggaagcgt gtgaatatat ctcaagaaaa gttgaagatg catggaaagt tataaaccga 1560
gagtcgctca ggcctacagc tgtcccattt cctctactta tgcctgcaat caaccttgca 1620
cgtatgtgtg aagtcctata tagcgtcaac gatggcttca ctcatgctga gggagacatg 1680
aaaagttaca tgaaatcgtt cttcgttcac cctatggttg tctaa                 1725

<210> 550
<211> 1985
<212> DNA
<213> Artemisia annua

<220> 
<223> 8-epi-cedrol synthase

<400> 550
caggaattcg attccgtact aattcgcatc ttttatcaag catgtctctt atagtagagg 60
atgtcatacg ccccaatgca aattttcctt ctgaaatttg gggagatcag tttcttgcct 120
atgaccagga tgagcaagag ggagttgaac aagtaatcaa agatttgaaa gaagaagtga 180
agagcgaact attgacagct ctaaattctc cgactcagca tacggagttg ttgaaattta 240
ttgacgcaat cgaacgcctt ggtattgcgt attattttga agaggagatc aaccaagtat 300
tccaacacat gtatactgca tatggtgata agtggacagg tggtaatact tccctttggt 360
ttcgactcat gcgacaacat ggatttttcg tttcaagcga tatttttagt acctacaaag 420
acaaagaggg acgttttaag gagtctttag aaaaggacgt tcacgggtta cttgagttgt 480
atgaggcggc atatatgttt gtgcctgggg aagggatact agatgatgct cttgttttta 540
caagaacttg tcttgatgaa atagcgaaaa atcctagtct aagtaactct gctgtttctt 600
cccaaatacg tgaagctcta acgcaacctt tacataaaag attaccgaga ctagaggcgt 660
tgcgctacat acctttctac caacaacaag cttctcacag tgagacattg ttaaaactgg 720
ccaaattagg gttcaaccaa cttcaatcac ttcacaagaa agagcttagc ataatttcca 780
agtggtggaa aagtttcgat gttgcaaaca atctaccgta tgcaagaaat agacccgttg 840
aatgctactt ttgggcatta gcagtgtact tcgagcctca atattctgaa tcaagagtct 900
tcttatcaag atttttttca atacaaacat ttcttgatga cacttatgat gcctacggta 960
cttacgaaga acttgaacaa tttactgaag caattcaaag gtggtcaata acatgcttgg 1020
acggtcttcc tgaaagcatg aagcttatat tccaaatgct agtgaagatt tttgaagaaa 1080
tagaggaaat attgtcgaag gatggaaaac agcatcatgt caactacatc aaagaaacac 1140
tgaaagaggc tgtccaaagc tacatgacag aagcaagatg ggcaaaagaa gagtatatac 1200
caacgattga ggagcacaca aaagtgtcat atattagcat cggctataaa cttgcgctag 1260
tagcaggttt tgcttgcatg ggtgatgtaa ttgcagatga ctcatttgaa tgggttttca 1320
ccaatcctcc tcttgtcaat gcttgttgtc tactttgtag aaccatggat gatcttggtt 1380
cccataaggg cgagcaagat agaaagcatg ttgcctccac tattgaatgc tacatgaagc 1440
aatttgatgc tagcgagcaa caagcctacg aatcactcaa caagaaagtt gaagatgcat 1500
ggaaagaaat aaatagagag ttcatgatca cgtgtaagga tgttaatatt catgtagcta 1560
tgagggtcct taatttttca cgttcggtgg atgtccttta taagaataag gatcacttta 1620
cacatgttgg agtagaggtg ataaatcata tcaaatctct tttcgttgat gccatcatta 1680
catgaattcc agttcttcgt gagctaccat gtcttacaga tttggaattt gaataagggt 1740
atgttactat gttttattgt ggttacattg aataacatgc caagttattt ggcatattat 1800
ggttcagcgg taccatcgct gtttatttct gcaagttgtc ttataaattg tcatgtaata 1860
ttaatgcgtg tgaggtttta atatttaacg acgatgatgt ttccatcttc gagtaaaaaa 1920
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1980
aaaaa                                                             1985

<210> 551
<211> 1946
<212> DNA
<213> Artemisia annua

<220> 
<223> 8-epi-cedrol synthase

<400> 551
tcagcgtata ctaattcgca tcttttatca agcatgtctc ttatagtaga ggatgtcata 60
cgccccaatg caaattttcc ttctgaaatt tggggagatc agtttcttgc ctatgaccag 120
gatgagcaag agggagttga acaagtaatc aaagatttga aagaagaagt gaagagcgaa 180
ctattgacag ctctaaattc tccgactcag catacggagt tgttgaaatt tattgacgca 240
atcgaacgcc ttggtattgc gtattatttt gaagaggaga tcaaccaagt attccaacac 300
atgtatactg catatggtga taagtggaca ggtggtaata cttccctttg gtttcgactc 360
atgcgacaac atggattttt cgtttcaagc gatattttta gtacctacaa agacaaagag 420
ggacgtttta aggagtcttt agaaaaggac gttcacgggt tacttgagtt gtatgaggcg 480
gcatatatgt ttgtgcctgg ggaagggata ctagatgatg ctcttgtttt tacaagaact 540
tgtcttgatg aaatagcgaa aaatcctagt ctaagtaact ctgctgtttc ttcccaaata 600
cgtgaagctc taacgcaacc tttacataaa agattaccga gactagaggc gttgcgctac 660
atacctttct accaacaaca agcttctcac agtgagacat tgttaaaact ggccaaatta 720
gggttcaacc aacttcaatc acttcacaag aaagagctta gcataatttc caagtggtgg 780
aaaagtttcg atgttgcaaa caatctaccg tatgcaagaa atagacccgt tgaatgctac 840
ttttgggcat tagcagtgta cttcgagcct caatattctg aatcaagagt cttcttatca 900
agattttttt caatacaaac atttcttgat gacacttatg atgcctacgg tacttacgaa 960
gaacttgaac aatttactga agcaattcaa aggtggtcaa taacatgctt ggacggtctt 1020
cctgaaagca tgaagcttat attccaaatg ctagtgaaga tttttgaaga aatagaggaa 1080
atattgtcga aggatggaaa acagcatcat gtcaactaca tcaaagaaac actgaaagag 1140
gctgtccaaa gctacatgac agaagcaaga tgggcaaaag aagagtatat accaacgatt 1200
gaggagcaca caaaagtgtc atatattagc atcggctata aacttgcgct agtagcaggt 1260
tttgcttgca tgggtgatgt aattgcagat gactcatttg aatgggtttt caccaatcct 1320
cctcttgtca atgcttgttg tctactttgt agaaccatgg atgatcttgg ttcccataag 1380
ggcgagcaag atagaaagca tgttgcctcc actattgaat gctacatgaa gcaatttgat 1440
gctagcgagc aacaagccta cgaatcactc aacaagaaag ttgaagatgc atggaaagaa 1500
ataaatagag agttcatgat cacgtgtaag gatgttaata ttcatgtagc tatgagggtc 1560
cttaattttt cacgttcggt ggatgtcctt tataagaata aggatcactt tacacatgtt 1620
ggagtagagg tgataaatca tatcaaatct cttttcgttg atgccatcat tacatgaatt 1680
ccagttcttc gtgagctacc atgtcttaca gatttggaat ttgaataagg gtatgttact 1740
atgttttatt gtggttacat tgaataacat gccaagttat ttggcatatt atggttcagc 1800
ggtaccatcg ctgtttattt ctgcaagttg tcttataaat tgtcatgtaa tattaatgcg 1860
tgtgaggttt aatatttaac gacgatgatg tttccatctt cgagtaataa tatgttattt 1920
agtttcaata aaaaaaaaaa aaaaaa                                      1946

<210> 552
<211> 2067
<212> DNA
<213> Artemisia annua

<220> 
<223> amorpha-4,11-diene synthase

<400> 552
gttttgaaaa tcatgtcact tacagaagaa aaacctattc gccccattgc caactttcct 60
ccaagcattt ggggagatca gtttctcatc tatgaaaagc aagtagagca aggggtggaa 120
cagatagtga atgatttaaa aaaagaagtg cggcaactac taaaagaagc tttggatatt 180
cctatgaaac atgccaattt gttgaagctg attgatgaaa tccaacgcct tggaataccg 240
tatcactttg aacaggagat tgatcatgca ttgcaatgta tttatgaaac atatggtgat 300
aactgggatg gtgaccgctc ttccttatgg ttccgtctta tgcgaaagca aggatattat 360
gttacatgtg atgttttcaa taactataaa gacaaagatg gagcgttcaa gcaatcgtta 420
gctaatgatg ttgaaggttt gcttgagttg tacgaagcaa cttctatgag ggtacctggg 480
gagattatgt tagaagatgc tcttggtttt acacgatctc gtcttagcat tatgacaaaa 540
gatgcttttt ctacaaaccc cgctcttttt accgaaatac aacgggcact aaagcaaccc 600
ctttggaaaa ggttgccaag aatagaggcg gcgcagtaca ttcctttcta tcaacaacaa 660
gattctcata acaagacttt acttaaactt gctaagttag agttcaattt gcttcagtca 720
ttgcacaagg aagagctcag ccatgtgtgc aagtggtgga aagctttcga tatcaagaag 780
aacgcacctt gtttaagaga tagaattgtt gaatgctact tttggggact aggttcaggc 840
tttgagccac agtattcccg ggctagagtt ttcttcacaa aagctgttgc tgttataact 900
cttatagatg acacttatga tgcgtatggt acttatgaag aacttaagat ctttactgaa 960
gctgttgaaa ggtggtcaat tacatgctta gacacacttc cagaatacat gaaaccgata 1020
tacaaattat tcatggatac atacacagaa atggaagaat ttcttgcaaa ggagggaaga 1080
acagatctat ttaactgcgg caaagaattt gtgaaagagt ttgttagaaa cctgatggtt 1140
gaagcaaaat gggcaaatga gggacacata ccaaccactg aagagcatga tccagttgta 1200
atcattactg gcggtgctaa cctgcttaca acaacttgtt atcttggcat gagtgatata 1260
ttcacaaaag agtctgtcga atgggctgtc tctgcacctc ctctttttag atactcaggt 1320
atacttggtc gacgcctaaa tgatctcatg acccacaagg ccgagcaaga aagaaaacat 1380
agttcatcga gccttgaaag ttatatgaag gaatacaatg tcaatgagga gtatgcccaa 1440
accttgattt acaaggaagt agaagatgtg tggaaagata taaaccgaga gtacctcaca 1500
actaaaaaca ttccaaggcc gttattgatg gctgtgatct atttgtgcca gtttcttgaa 1560
gttcaatatg caggaaagga taacttcaca cgtatgggag acgaatacaa acatctcata 1620
aagtctctac tcgtttatcc tatgagtata tgactaccaa tccttcgtgc atagcctatc 1680
aattatattg aaagggttaa ctatgcatgt ctctatgaag agaatttctc aagctatttg 1740
gtgtttcttg ctggcaataa taaatcagac gcataaaatt gtattgaact atatgccgat 1800
agctatttaa agttattata caactaaaat attcataaat ggtattatac ttttactttg 1860
tacaaaagca aaagtacact actgttatgt aacattttag ttctatgata ctttagttac 1920
gaatcggctt atatacattg atacactttt atgcagaaaa ccctactaaa taaaaagtcg 1980
atatcttgta ctacacatat cgcacgaatt tccgtttgcc gtttgtattt ttgatatgtt 2040
atttaatgaa tatgtttcat gtggttg                                     2067

<210> 553
<211> 1902
<212> DNA
<213> Artemisia annua

<220> 
<223> (E)-beta-caryophyllene synthase

<400> 553
cataatccaa acttctcata gacatgtctg ttaaagaaga gaaagtaatt cggcccattg 60
tccactttcc tcctagcgtt tgggcagacc agtttctcat cttcgatgac aagcaagcag 120
agcaagccaa tgtagaacaa gtagtcaacg agttaagaga agatgtgaga aaagatttag 180
tgtcatcttt agatgttcaa acggagcaca caaatttgct aaaacttatt gatgctatcc 240
aacgtcttgg tatagcgtat cattttgaag aggagattga gcaagcctta caacatattt 300
atgatacata tggtgatgac tggaaaggca gaagcccttc cctttggttt cgaatccttc 360
ggcaacaagg tttttatgtt tcttgtgata tttttaaaaa ctataaaaaa gaggatggtt 420
catttaagga atccctcacc aacgatgtag aaggcttgct tgagctgtat gaggcgacat 480
atttgagagt gcaaggcgaa ggggttctag atgatgctct tgttttcaca aggacttgtc 540
ttgagaaaat agcaaaggat cttgttcaca ccaacccaac actatctacc tacatacaag 600
aagcactaaa acagccgtta cataaaaggt tgacaagact agaggcattg cgttacattc 660
ctatgtacga acaacaagca tctcataatg agtctttact caaacttgcg aagctaggtt 720
tcaacttact tcaatcattg catagaaagg agcttagcga agtttccagg tggtggaaag 780
gtcttgatgt cccaaacaat ctaccttatg caagagatag aatggttgaa tgttattttt 840
gggcactagg tgtctatttt gagccaaaat attctcaagc taggatcttt ttagcaaaag 900
taatttcgct agcaactgtt cttgacgaca cttatgatgc ttatggaacc tatgaagaac 960
ttaagatctt tactgaagca attcaaaggt ggtcgattac atgcatagat atgcttccag 1020
aatacctgaa actattatac caaggagtct tggatatata catagaaatg gaagaaataa 1080
tgggaaaaga gggaaaagca catcatctta gctatgctaa agaatctatg aaagagttta 1140
ttagaagcta tatgatggaa gcaaaatggg caaatgaggg gtatgtacca acagcagagg 1200
agcatatgtc agttgcgttt gtaagcagcg ggtatagcat gcttgcaaca acatgttttg 1260
ttggcatggg tgatatcgtt acagatgaag cattcaaatg ggctctgaca aaacctccta 1320
tcatcaaagc ttcatgtgca attgctagac tcatggatga tattcactct caaaaggagg 1380
agaaagaaag aatacatgtt gcatctagtg ttgaaagtta catgaagcaa tatgatgtga 1440
cagaggagca tgtccttaaa gtatttaaca agaaaatcga ggatgcgtgg aaagatataa 1500
cccgagaatc ccttgtgcgt aaagatattc cgatgcctct gatgatgcga gtgattaact 1560
tggcacaggt gatggatgtt ttatataaac ataaagacgg tttcactaat gtgggagaag 1620
aactcaagga tcatattaaa tctttgctcg ttcatcctat acctatataa gttccgaaac 1680
ttcatctcgt ttttagcctc cgatacactc aacaactcaa ctttctctca tcttcaaatg 1740
gttggttgtg gcaaatctta agtccttggg tgattgaaat cttcaaatgc gtgtttgtta 1800
ctacatgcat gtgatttttt tccccctctt ctgtgtggca tttgtatttg gatgatttaa 1860
taataaataa aggtgtgttt gtgttaaaaa aaaaaaaaaa aa                    1902

<210> 554
<211> 1689
<212> DNA
<213> Artemisia annua

<220> 
<223> germacrene A synthase

<400> 554
atggcagcgg ttcaagctaa tgttactggt atcaaagcaa acaccaaaac ctccgcagag 60
ccagtgcggc cgttggccaa ctttcctcct tcagtatggg gtgatcgctt cctttcattc 120
tctcttgaca gatcggaatt ggagcgatat gccatagcta tggagaagcc gaaggaggac 180
ttgagaaagt tgatcgtgga tccgaccatg gattctaatg agaaactagg tttgatttat 240
tctgtgcatc gtctcggttt gacatatatg ttcttgcaag agatcgaaag ccagcttgac 300
aagcttttca acaagtttag cttgcaagat tatgaagaag ttgatctgta cactatttcg 360
attaattttc aagtttttcg acacgttggt tacaaactac cttgtgatgt ctttaacaaa 420
ttcaaggacg ttagctcggg tactttcaag gcatccatta cgagtgatgt gggggtagtt 480
gggctatatg aatctgcaca gttgagaata agaggagaaa agatacttga tgaagcctca 540
gttttcactg aagctaaact caagagtgta gtgaacactc ttgaaggtga tcttgcacaa 600
caagtgacac aatctttaag gagaccattc catcaaggga tgccattggg tattaggcaa 660
ggctctattt ctctaactat gaaaaagaat gttccactta tgactcattg cttaaagctt 720
gcaaagcttc actttaagta tttggagcta caacaaaaag aagaactgcg aattgtatca 780
aagtggtgga aggatatgag gtttcacgaa actactcctt atataaggga tagagtacca 840
gagatttact tatggatatt gggattatac tttgagcctc gttactcctt ggcaagaatc 900
atcgcaacaa aaataacgtt gtttctcgtg gttttagatg acacatatga tgcttatgct 960
accattgaag agattcgcct tctaacagat gctataaaca agtgggatat tagtgctatg 1020
gagcaaattc cagagtatat tagaccattt tacaaaattc ttttagatga atatgctgga 1080
aattggagaa gaaaatggct gaagaaggga gagcaaatac tgttattgct tcaaaagaag 1140
cgttccaaga cattagctag aggttacctt gaagaggctg aatggacaaa cagtggatat 1200
gtggcatcat ttccggagta tatgaagaat ggattaatca cttctgctta taatgtcatt 1260
tcaaaatcgg ctttagttgg tatgggtgag attgttagtg aagatgcttt ggcttggtat 1320
gaaagtcatc caaagacttt gcaggcttct gagttgattt caagacttca agatgatgtc 1380
atgacttacc agtttgaacg tgaaagaggt caatctgcca ctggcgttga tgcgtatatt 1440
aagacttatg gtgtctcaga aaaggaagct attgacgcgc tcaagatcat gattgagaat 1500
gcatggaaag atataaacga gggatgtcta aagccaagac aagtctcaat ggatttgctt 1560
gctccaattc ttaaccttgc aagaatgata gatgtggtat acaggtacga cgacgggttc 1620
acttttccaa ggaaagactc tgaaagagta tatcaatcct tctgtttgtg ggttctctac 1680
cccgtgtaa                                                         1689

<210> 555
<211> 1893
<212> DNA
<213> Artemisia annua

<220> 
<223> putative sesquiterpene cyclase

<400> 555
tcagcgtata ctaattcgca tcttttatca agcatgtctc ttatagtaga ggatgtcata 60
cgccccaatg caaattttcc ttctgaaatt tggggagatc agtttcttgc ctatgaccag 120
gatgagcaag agggagttga acaagtaatc aaagatttga aagaagaagt gaagagcgaa 180
ctattgacag ctctaaattc tccgactcag catacggagt tgttgaaatt tattgacgca 240
atcgaacgcc ttggtattgc gtattatttt gaagaggaga tcaaccaagt attccaacac 300
atgtatactg catatggtga taagtggaca ggtggtaata cttccctttg gtttcgactc 360
atgcgacaac atggattttt cgtttcaagc gatattttta gtacctacaa agacaaagag 420
ggacgtttta aggagtcttt agaaaaggac gttcacgggt tacttgagtt gtatgaggcg 480
gcatatatgt ttgtgcctgg ggaagggata ctagatgatg ctcttgtttt cacaagaact 540
tgtcttgatg aaatagcgaa aaatcctagt ctaagtaact ctgctatttc ttcccaaata 600
cgtgaagctc taacgcaacc tttacataaa agattaccga gactagaggc gttgcgctac 660
atacctttct accaacaaca agcttctcac agtgagacat tgttaaaact ggccaaatta 720
gggttcaacc aacttcaatc acttcacaag aaagagctta gcataatttc caagtggtgg 780
aaaagtttcg atgttgcaaa caatctaccg tatgcaagaa atagacccgt tgaatgctac 840
ttttgggcat tagcagtgta cttcgagcct caatattctg aatcaagagt cttcttatca 900
agattttttt caatacaaac atttcttgat gacacttatg atgcctacgg tacttacgaa 960
gaacttgaac aatttactga agcaattcaa aggtggtcaa taacatgctt ggacggtctt 1020
cctgaaagca tgaagcttat attccaaatg ctagtgaaga tttttgaaga aatagaggaa 1080
atattgtcga aggatggaaa acagcatcat gtcaactaca tcaaagaaac actgaaagag 1140
gctgtccaaa gctacatgac agaagcaaga tgggcaaaag aagagtatat accaacgatt 1200
gaggagcaca caaaagtgtc atatattagc atcggctata aacttgcgct agtagcaggt 1260
tttgcttgca tgggtgatgt aattgcagat gactcatttg aatgggtttt caccaatcct 1320
cctcttgtca atgcttgttg tctactttgt agaaccatgg atgatcttgg ttcccataag 1380
ggcgagcaag atagaaagca tgttgcctcc actattgaat gctacatgaa gcaatttgat 1440
gctagcgagc aacaagccta cgaatcactc aacaagaaag ttgaagatgc atggaaagaa 1500
ataaatagag agttcatgat cacgtgtaag gatgttaata ttcatgtagc tatgagggtc 1560
cttaattttt cacgttcggt ggatgtcctt tataagaata aggatcactt tacacatgtt 1620
ggagtagagg tgataaatca tatcaaatct cttttcgttg atgccatcat tacatgaatt 1680
ccagttcttc gtgagctacc atgtcttaca gatttggaat ttgaataagg gtatgttact 1740
atgttttatt gtggttacat tgaataacat gccaagttat ttggcatatt atggttcagc 1800
gttaccatcg ctgtttattt ctgcaagttg tctttttaat tgtcatgtaa tattaatgcg 1860
tgtgaggttt taatatttaa cgacgatgat gtt                              1893

<210> 556
<211> 1843
<212> DNA
<213> Artemisia annua

<220> 
<223> putative sesquiterpene cyclase

<400> 556
gtggtatcaa cgcagagtgg ccattatggc cggggaatat caaactcgca agattttgag 60
atgtcgactc ttcctatttc tagtgtttct ttctcttcat ctacgtcacc tttggttgtt 120
gatgataaag ttagcacgaa accagatgtt atccgccata ccatgaattt caatgctagc 180
atatggggag atcaatttct tacatatgat gagccagaag atttggttat gaagaaacaa 240
cttgttgaag agctgaaaga ggaagtcaaa aaagagctaa taacgatcaa aggttcaaat 300
gaaccgatgc agcatgtcaa gttgatagaa cttattgatg cagtccaacg gcttggcata 360
gcctatcatt ttgaagagga gattgaagaa gccttgcaac atatccatgt tacatatggc 420
gagcagtggg tcgataaaga aaacctacaa agcatttctc tttggttccg actcctacga 480
caacaaggct tcaacgtctc atcaggagta ttcaaagact ttatggacga gaagggaaaa 540
tttaaggaat ccttatgtaa tgatgctcag ggaattcttg ctctgtatga agcggcattt 600
atgagggtgg aagatgaaac aatactagat aatgcgctcg agttcactaa agttcacctt 660
gacatcatag ccaaggatcc ttcttgtgac tcttccctaa gaacccaaat acaccaagcg 720
ttaaagcagc cacttaggag aaggctggca aggattgagg cgttgcatta catgcctatc 780
taccaacaag aaacatccca caatgaggac ttactgaagc ttgcaaaatt agattttagc 840
gtgcttcagt cgatgcacaa aaaggaactt agccacattt gcaaatggtg gaaggatttg 900
gacctccaaa ataagcttcc ttatgttcga gacagggtgg tggaaggcta tttttggata 960
ctatccatct attacgagcc tcaacatgct cgaacaagaa tgttcctaat gaaaacatgc 1020
atgtggttag tcgttttaga tgatacattt gataattatg gtacttatga agaactcgaa 1080
atctttacac aagctgttga aagatggtca ataagctgcc tggatatgct tccagaatac 1140
atgaaactaa tatatcaaga gcttgtgaat cttcacgtgg aaatggagga atcacttgga 1200
aaaggaggga aaaacatatc aaattcacta tgtcaaggaa gatggcaaaa agagttgggt 1260
tcgcaaatta ctttggtaga aaccaagatg gctaaaagag gggtacatgc ccaacctctt 1320
gaggagtaca tgtctgtgtc aatggtgact ggtacctatg gcttgatgat agcgagatct 1380
tatgtcggca ggggtgatat cgtcaccgag gataccttta aatgggtgtc ctcgtatcct 1440
cctattataa aagcttcatg tgtgattgta agacttatgg atgatattgt cagccacaag 1500
gaggaacaag agagaggcca tgttgcttca agcatcgaat gctattctaa ggaaagtggt 1560
gcatcagagg aggaagcgtg tgaatatatc tcaagaaaag ttgaagatgc atggaaagtt 1620
ataaaccgag agtcgctcag gcctacagct gtcccatttc ctctacttat gcctgcaatc 1680
aaccttgcac ggatgtgtga agtcttatat agcgtcaacg atggcttcac tcatgctgag 1740
ggagacatga aaagttacat gaaatcgttc ttcgttcacc ctatggttgt ctaagattat 1800
tctgtttgtt ctaatgtact aattaatttg tgggcttgtt gcg                   1843

<210> 557
<211> 2026
<212> DNA
<213> Artemisia annua

<220> 
<223> putative sesquiterpene cyclase

<400> 557
tcgcccgggt tggtacataa tccaaacttc tcatagacat gtctgttaaa gaagagaaag 60
taattcggcc cattgtccac tttcctccta gcgtttgggc agaccagttt ctcatcttcg 120
atgacaagca agcagagcaa gccaatgtag aacaagtagt caacgagtta agagaagatg 180
tgagaaaaga tttagtgtca tctttagatg ttcaaacgga gcacacaaat ttgctaaaac 240
ttattgatgc tatccaacgt cttggtatag cgtatcattt tgaagaggag attgagcaag 300
ccttacaaca tatttatgat acatatggtg atgactggaa aggcagaagc ccttcccttt 360
ggtttcgaat ccttcggcaa caaggttttt atgtttcttg tgatattttt aaaaactata 420
aaaaagagga tggttccatt ttaaggaatc ccctcaccaa cgatgtagaa ggcttgcttg 480
agctgtatga ggcgacatat ttgagagtgc aaggcgaagg ggttctagat gatgctcttg 540
ttttcacaag gacttgtctt gagaaaatag caaaggatct tgttcacacc aacccaacac 600
tatctaccta catacaagaa gcactaaaac agccgttaca aaaaaggttg gcaagactag 660
aggcattgca ttacattcct atgtacgaac aacaagcatc tcacaatgag tctttactca 720
aacttgcgaa gctaggtttc aacttacttc aatcattgca tagaaaggag cttaacgaag 780
tttccaggtg gtggaaaggt cttgatgtcc caaacaatct accttatgca agagatagaa 840
tggttgaatg ttatttttgg gcactaggtg tctattttga gccaaaatat tctcaagcta 900
ggatcttttt agcaaaagta atttcgctag caactgttct tgacgacact tatgatgctt 960
atggaaccta tgaagaactt aagatcttta ctgaagcaat tcaaaggtgg tcgattacat 1020
gcatagatat gcttccagaa tacctgaaac tattatacca aggagtcttg gatatataca 1080
tagaaatgga agaaataatg ggaaaagagg gaaaagcaca tcatcttagc tatgctaaag 1140
aatctatgaa agagtttatt agaagctata tgatggaagc aaaatgggca aatgaggggt 1200
atgtaccaac agcagaggag catatgtcag ttgcgtttgt aagcagcggg tatagcatgc 1260
ttgccacaac atgttttgtt ggcatgggtg atatcgttac agatgaagca ttcaaatggg 1320
ctctgacaaa acctcctatc atcaaagctt catgtgcaat tgctagactc atggatgata 1380
ttcactctca aaaggaggag aaagaaagaa tacatgttgc atctagtgtt gaaagttaca 1440
tgaagcaata tgatgtgaca gaggagcatg tccttaaagt atttaacaag aaaatcgagg 1500
atgcgtggaa agatataacc cgagaatccc ttgtgcgtaa agatattccg atgcctctga 1560
tgatgcgagt gattaacttg gcacaggtga tggatgtttt atataaacat aaagacggtt 1620
tcactaatgt gggagaagaa ctcaaggatc atattaaatc tttgctcgtt catcctatac 1680
ctatataagt tccgaaactt catctcgttt ttagcctccg atacactcaa caactcaact 1740
ttctctcatc ttcaaatggt tggttgtggc aaatcttaag tccttgggtg attgaaatct 1800
tcaaatgcgt gtttgttact acatgcatgt gatttttttc cccctcttct gtgtggcatt 1860
tgtatttgga tgatttaata ataaataaag gtgtgtttgt gttatgcgaa tgagaaagag 1920
ggcgtctgct tgaatatttg aaaaagtgtt tatttggtat gtttagtgaa ttaaagcatg 1980
ctaaactgta aaatttcaac cataataata cttaaatttc aacccc                2026

<210> 558
<211> 1886
<212> DNA
<213> Artemisia annua

<220> 
<223> sesquiterpene cyclase

<400> 558
tattctaaca tcgtatcagc cttagaacat acctaagagc gatgtccact tttctagttt 60
gtaatgcctc attctctcca tcttatggtt taccatcatc atgtgatcgt aatagtagca 120
tgaaccaaga gatcgtccgc aacactgtta aatttcctcc tagcatatgg ggagatcagt 180
ttcttacata ccatgaaccg aaaaaaagtt taaccattga gaaacaacat gttgaagagg 240
ttgaagaaat aaggaaaaag ctattgaaca cagcttttag tgagccaaag cagcatacga 300
agctaataca tcttatagat tcagttcaac gccttggagt atcctatcat tttgaacaag 360
aaattgagga agccttgcag catgtctatg ctacacatgg tgatcagtgg attggcaagg 420
acaacctgaa aagtacatca caatggttcc gaatcctaag acaacaaggt tttaatgttt 480
catctggaat cttcgagaac catatggatg acaagggaaa atttaaggaa cacttgagtg 540
acgatgttca aggcatgctt ggtttgtatg aagcagcata tatgagtgtg gaaggcgaaa 600
aagaattaga tgatgccctc gaattcacta aaactcacct tggaaacata gcaaaggatc 660
cttctcagaa tgcttcttta agaaccaaaa tagaacaagc actaaacaga ccacttcgga 720
aaaggatgcc aaggctagag gcactgcatt acatacctaa ataccaacaa gaagcttctc 780
atgacgagac cttgttaaat cttgcaaagt tggattataa catgcttcaa tcaatacaca 840
aaagggagat tagtgaaatc tgcaaatggt ggaaggattt ggatttctca aacaaactac 900
cgcatgttcg agatagattg gttgaaatat atttttgggt attgggggtc tattttgaac 960
ctcaacatta tcgttcaagg atgtttctca ccaaaacgag tatgtggtta attgttcttg 1020
atgacacata tgataattat ggtacttacg aagaacttaa gatctttacg gaagctgttc 1080
agagatggtc cttaagctgc ttggactcac ttccagaata catgaaatta atatatcgag 1140
aacttataaa tcattaccag gaaatggaag aatcagttga aaaggaagga aaatcatatc 1200
aattattcta tgctaaagag atggtaaaag aaaattgtcg aaacctctta gtggaagcaa 1260
aatggttaaa agaaggatac gtaccaacac ttgaggaaca catgtcggtt tcatgtgtta 1320
cttatgccta tgctgtcatg atcgcaaact cttatgttgg acgggaaaat atggttacag 1380
aggagtcctt taagtgggtt gccaaatttc ctcctcttgt taatgctaca tgtttgattt 1440
taaggcttat ggatgatatc gcgggccacg aggaggaaca agaaagagac catgttgttt 1500
caagtattga atgctacaga aatgaaactg gagcctcgga ggaggatgcc gttaagtttc 1560
tttcaaaaca agttgaggat gcatggaaag ttataaataa ggagtgtcta aggcctacag 1620
aaattcccat gtctctaact atacctccac tcagccttgc tcgtgtgagt gatatccttt 1680
ataaaacgaa taatggttac aatcacgcag gggaagaagt gatcagttac attaagtcgc 1740
tccttgttca tcctttagtt taatggcatt tgatggttct cgatcagtac tccgtcaatt 1800
tatgtaacac cagcgatttc gcaaaacctt atgaataaac gaagatgatt tacatgggtt 1860
tctaaaaaaa aaaaaaaaaa aaaaaa                                      1886

<210> 559
<211> 963
<212> DNA
<213> Aspergillus terreus

<220> 
<223> aristolochene synthase

<400> 559
atgaagaaac ccaatggcac gaatggagct tccagctctc ttgagccacc cccctctacg 60
ttccaacctc tctgccatcc gctggtggag gaggtcagca aggaggtgga tggttacttc 120
ctccagcact ggaactttcc caatgagaag gcccgcaaga agtttgtagc tgcagggttc 180
tcccgggtaa cgtgcctgta ctttccgaag gcgctggatg accgcatcca ctttgcctgc 240
cgtctgctga cggtgctgtt cctgattgat gatctgctgg aatacatgtc gttcgaggaa 300
ggttccgctt acaacgagaa gctcatcccg atctcacgcg gagatgtcct tccagaccgg 360
tccattcctg tggagtacat tatctacgat ctgtgggaga gcatgcgcgc ccacgatcgc 420
gagatggcag acgagatcct ggagccggtg ttcctgttca tgcgggcaca gacggaccgc 480
acccgagccc ggccgatggg cttgggtggg tatctcgagt accgcgagcg tgatgtgggc 540
aaagagcttc ttgctgcgct catgcgcttc tccatggggc ttaagctgtc tccgtccgag 600
ctccagcgcg tgcgcgagat cgacgccaac tgctcgaaac atctgtccgt cgtgaacgac 660
atctacagct atgagaagga gctctacacc tccaagactg cccatagcga aggcgggatc 720
ctttgcacct cggtgcagat cctggcccag gaggcggacg tgaccgcaga ggctgccaaa 780
cgggtcctgt tcgtcatgtg tcgggagtgg gagctccgtc atcagttgct cgttgcacgg 840
ctgagtgccg agggtctgga aacgcccgga ctggcggcgt acgtggaggg actcgagtat 900
cagatgagtg gcaatgagct gtggagtcag acaacgttgc ggtatagtgt ggtagttgac 960
tag                                                               963

<210> 560
<211> 3515
<212> DNA
<213> Capsicum annuum

<220> 
<223> 5-epi-aristolochene synthase

<400> 560
gagaagttta tggtaatttt gttaatacta tcctatcatt aaatgattat gtaaggtgta 60
aatattcaaa ttttcatttt caattcataa ttaataggat tagtttagta aaataagcct 120
ctattaaata ttttatttcg aagagtgtca agtcaacaag atcacctaaa acaaaacgca 180
acaagtatat cctaatatcc cacgtgttat gtcgtaaaat gcatacaagt tatgcctctg 240
acacggaaca gatatttttc tttattcaca aaaatgcttc tactttaatc tttgttcagt 300
gaccaaaaat tatcttgcaa atatgttctt gtatgatgtc aggtagggca actaggaaac 360
tattataaga taaactcact cttataataa ttaataagtg atagattttc cttgttctgt 420
atagggtcaa gtagggcgac tgggagatat taaaagatgg aggctcattc tgttttttaa 480
ttccccaatg atatgtctat caccacaata aaaactagtc cctcgtctac caccaatttc 540
atcaacaatg agaggggatt tcattcttcc tctaagaacc aacagcagta ctcttattat 600
ctgttgcaac aatggcctca gttgcagttg aaaataatgt tgtgaaccat attgcagaag 660
agatcattcg ccccgttgcc gactattctc caagtatatg gggggatcgt ttcctctctt 720
tctccatcga caaccaggta attagttaat attcgtcatc tttttttcat agtaccctcc 780
ttgttctttg ctggtattag acaacgtagt ttgatttctt tatactattg gagatattta 840
taggtcgaac aaaagtatgc tcaagaaatt gaaccgccga aggaacaaac aaggagtatg 900
ttgttagcat ccccaaggaa attgtcggat acattgaatt tgattgatgt tattgaacgt 960
cttgcaatag cctatcactt tgagaaagaa atcgatgaga ttttggatcg gatttacaat 1020
gaaaattcaa acttcgaggg cgatgtctat aatgaagatc tatgcacttg tgctctccaa 1080
ttccgattgc ttaggcaaca tggatataat atctctctaa gtacgtacct cttgaagtac 1140
tacaattgca atattgtcac aattatacat agatatataa tccgtttgat atgaaggccg 1200
gctaatattg tgtattcttc cttgaaaatc agaaattttc agcaaattcc tagatggaaa 1260
tggcagacta aaggagtctc ttgctagtga tgtcctagga ttattgagct tgtatgaagc 1320
ttcacatgta aggtctcatg gtgaagacat cttagaagat gcactcgctt tctccactac 1380
tcatctagag tctgcaactc cacatttgga atatcctctt aaggagcaag tgaggcatgc 1440
ccttgagcaa tctttgcaca aaggtattcc tcgaattgag attcaattct tcatctcatc 1500
aatctacgac aagcaggcaa taaagaatga tgtgttactt cgatttgcca aattggatta 1560
caacatgctc caaatgctgc acaaacaaga acttgctgaa gtatcacggt gagattatat 1620
aaaaacggta aaaaattttg attgatcatt tatcaagtaa gtactgatgt taatttgtta 1680
tgccgcaggt ggtggaaaga tttaaatttt gtgaacacac ttccatatgc tagagataga 1740
gtagttgaat gctacttttg ggcattagga gtatattatg agcctcaata ttctcaagct 1800
cgtgtcatgc tagttaagac catagcaatg atttcgattg tggatgacac ctacgaggct 1860
tatggtacag ttgacgaact tgccatatac acggatgtca tacaagggta tggacttcat 1920
caattcactt gctcaaatat accttgaaag agaatatcyt gaaaaacatt waaccmrgca 1980
tttgctcatt atatttatcc taatttacct tatctttgtc acctttcaga tgggatatta 2040
aaagaattga tagtctgcct gattacatga aaatcagtta caaagctctt ctagatcttt 2100
acaaggacta tgaaaaggaa atgtctagag atggaagatc tcacgttgtt tattacgcaa 2160
aagaaagagt gagtctcaac gacttaacta tcaatttact tttatccttt atacatttct 2220
gtctttgctt tttcctcaca tgtttttgtg aatataaact agaggtaatt gggttacaat 2280
tttctaacac tttgaatttg tatgcttggt tttcacagct gaaagaattg gtaaaaagtt 2340
ataatattga ggcaaaatgg tttattgaag gacatatgcc tcctgcttct gaatacctgc 2400
gcaatgcatt tgtaactacc acttactact atcttgccac aacatcgtat ttggggatga 2460
agtatgctaa ggagcagcaa tttgagtggt tgtcgaaaaa tcctaagatt cttgaaggtt 2520
gtgtgacaat atgccgagtt attgatgaca tagccacata cgaggtatga gactatgagt 2580
tgtttctcat aaagttgtaa catcataagt tatttgaaca aatagattgt tgttaacaat 2640
cgaagaaatg taaaagctaa cgcctaatta aatcgccttt gcaggtagag aaaaataggg 2700
gacaactttc aactggaatt gagtgctaca tgagagatta tagtgtatcg acaaaagagg 2760
caatggctaa atttcaagaa atgggtgagt cgggatggaa ggatattaat gaaggaatgc 2820
ttaggccgac tcccatacct atggagtttt tatctcgcat tctcaatctt gctcgacttg 2880
ttgacgttac atataaacac aatgaagatg gatacactca tcccgagaaa gtcataaaac 2940
ctcacatcat tgcaatggtt gttgactcgt tcaaaattta agctgccaat cgttggtctt 3000
aataaaatct tttcgagaaa gtaatatgtt tttatcatta ttattcggat aaaaattcaa 3060
tggagcttca tttgtagttg tgcagtgcat tgccaaaatt tatttatttt tttcattatg 3120
tcatttcttc cttgtacacc tcaagtcgac catttgaagt ttctaatcta gtatggttca 3180
tattgactta tgtactatta tttcctttta ccaaaatcaa caaaataata cttctcatag 3240
atgtttgtgt tgtctttgct ctcattcttt ctcattttat tttttaggtt ttataaatsa 3300
gaacaaaagt ttwtaaaatt tattcgctaa cactactaaa aacttggcta ttagctgcca 3360
aggttagaga ggaacaaatt gtatatgtcg atatagtgag ggactttgag asraagtctc 3420
acataacwaa ttaaatattt ttattttttt atttttttta aacgacgatg ggagatcyca 3480
taaatatgat gatagtaaaa gccatataat ttcta                            3515

<210> 561
<211> 1918
<212> DNA
<213> Capsicum annuum

<220> 
<223> 5-epi-aristolochene synthase

<400> 561
aacagcagta ctcttattat ctgaagcaac atggcctcag ttgcagttga aaataatgtt 60
gtgaaccata ttgcagaaga gatcattcgc cctgttgccg acttttctcc aagtctatgg 120
ggtgatcgtt tcctttcttt ctccatcgac aaccaggtcg aaacaaagta tgctcaagaa 180
attgaaccgt tgaaggaaca aacaaggagt atgttgttag catccggaag gaaattgtcg 240
gagacattga atttgattga tgttattgaa cgtcttggca tagcctatca ctttgagaaa 300
gaaatcgatg agattttgga tcggatttac aatgaaaatt caaacttcga gggcgatgtc 360
tataatgaag atctatgcac ttgtcgtctc caattccgat tgcttaggca acatggatat 420
aatatctctc taaaaatttt cagcaaattc ctagatggaa atggcagact caaggagtct 480
cttgctagtg atgtcctagg attattgagc ttgtatgaag cttcacatgt aaggtctcat 540
ggtgaagaca tcttagaaga tgcactcgct ttctccacta ctcatctaga gtctgcaact 600
ccacatttgg aatatcctct taaggagcaa gtgaggcatg cccttgagca atctttgcac 660
aaaggtattc ctcgaattga gattcaattc ttcatctcat cggtctacga caagcaggca 720
ataaagaatg atgtgttact tcgatttgcc aaattggatt acaacatgct ccaaatgctg 780
cacaaacaag aacttgctga agtatcacgg tggtggaaag atttaaattt tgtgaacaca 840
cttccatatg ctagagatag agtagttgaa tgctactttt gggcattagg agtatattat 900
gagcctcaat attctcaagc tcgtgtcatg ctagttaaga ccatagcaat gatttcgatt 960
gtggatgaca cctacgatgc ttatggtaca gttgacgaac ttgccatata cacggatgtc 1020
atacaaagat gggatattaa agaaattgat agtctgcctg attacatgaa aatcagttac 1080
aaagctcttc tagatcttta caaggactat gaaaaggaaa tgtctagaga tggaagatct 1140
cacgttgttt attacgcaaa agaaagactg aaagaattgg taaaaagtta taatattgag 1200
gcaaaatggt ttattgaagg acatatgcct cctgcttctg aatacctgcg caatgcattt 1260
gtaactacca cttactacta tcttgccaca acatcgtatt tgggaatgaa gtatgctaag 1320
gagcagcaat ttgagtggtt gtcgaaaaat cctaagattc ttgaaggttg tgtgacaata 1380
tgccgagtta ttgatgacat agccacatac gaggtagaga aaaatagggg acaactttca 1440
actggaattg agtgctacat gagagattat agtgtatcga caaaagaggc aatggctaaa 1500
tttcaagaaa tgggtgagtc gggatggaag gatattaatg aaggaatgct taggccgact 1560
cccataccta tggagttttt atctcgcatt ctcaatcttg ctcgacttgt tgacgttaca 1620
tataaacaca atgaagatgg atacactcat cccgagaaag tcataaaacc tcacatcatt 1680
gccatggttg ttgactcgtt caaaatttaa gctgccaatc gttggtctta ataaaatctt 1740
ttcgagaaag taatatgttt ttatcattat tattcggata aaaattcaat ggagcttcat 1800
ttgtagttgt gcagtgcatt gccaaaattt atttattttt ttcattatgt catttcttcc 1860
ttgtacacct caagtcgacc atttgaagtt tctaatctag tatggttcat attgactt   1918

<210> 562
<211> 1953
<212> DNA
<213> Cichorium intybus

<220> 
<223> germacrene A synthase long form

<400> 562
gtttcattaa agatcatcca atccgaaaaa tggctctcgt tagaaacaac agcagcaatg 60
gtcgggagcc agttctcagc cccagaagtc tcacaagtcc tcgaggctta accagccccc 120
gaccgttgtc tgtccaaccg actccagagc cggttcgacc tttggccaac ttcccacctt 180
cgatctgggc tgatcgcttc atctcattct ctcttgataa ctctcaattg gaagcttatg 240
caaatgcact tgaagaacca aaagaagcag tgaagagttt aataaccgac actaccattg 300
atgcaaacac aaaactgaaa ttgatttatt cagtgcaccg tcttggtttg tcgtatcttt 360
atccagatga gattgatgcc gaactcaaca aactcttcga gaagattgac ttacagtatt 420
acgaacaagt tgatttgtac actattgcag tacaatttca agttttcaga caccatggtt 480
ataaaatttc ttctgatgtg tttaaaaagt tcaaggacag tactacgggt acattcacgg 540
atgatgtaac aaaagacgtg aagggtatgc tgagtttata cgaatcagca cacttaaggc 600
tacacggtga agatatctta gatgaagctt tagcattcac cgaagctcac cttaaaaaaa 660
tcctaaccac acttgaagga gatcttgcac gccaagtgaa ccaagtctta aaaagaccct 720
tccacactgg aatgccaatg gtagaggcac ggctatattt tatcacacac gaagaagatt 780
tttcaagcca tgagtcggtt gtaaagctag ctaaagtcca cttcaactat ttgcaactac 840
aacaaaaaga agaactacga ctcgtgtcac agtggtggaa agatatgcaa ttccaacaat 900
ccgtccctta cataagagat agagtaccgg agatatacct atggattttg gggttatatt 960
tcgagccgta ttactctcgg gcacgtatca tagccactaa aatcacgttg ttcttggtgg 1020
ttttggacga tacatatgac gcgtatgcta caattgacga gatccgatcg atcacagatg 1080
cgattaatag gtgggaaatt agcgcgatcg accaacttcc tgaatatatc aaaccgttct 1140
acagaattct cctcaacgaa tatgatgacc tcgagaaaga atactcaaag gacggaagag 1200
cgttcagtgt ccacgcttca aaacaagcgt ttcaagaaat cgcgagaggg tatcttgaag 1260
aggcggagtg gttacacaac ggttatgtgg caacatttcc cgagtatatg aagaatggtt 1320
tgattacttc ggcttataat gtcatttcaa aatccgcatt ggtgggaatg ggtgcgattg 1380
cagatgaaga ggctcttgct tggtatgaaa cacatccgaa aattttgaaa gcttcagagt 1440
tgatttcaag gctccaagac gatgttatga ctttccagtt tgagagaaaa cgaggacaat 1500
cagcaactgg tgtggatgct tatatcaagg aatacaatgt atccgaagaa gtagcgatca 1560
aagagctcat gaagatgatt gaaaacgcat ggaaagatat aaatgaggga tgcttgaagc 1620
ccactgaggt ctcggtggct ctactaactc ctattttgaa tctcgcgaga atgatagatg 1680
tcgtatacaa attcgatgat ggattcacct ttcccgggaa aaccctaaaa gactatatta 1740
cccttttgtt cgttagtcct ccaccgagtc tcgaaaactg ataggttgta atataagcat 1800
catattttct cggaattttg ctttttcatg ttgcgtatgt ttgcgacttt cgctcaattt 1860
ggtgagattc tttttgacat tctattgtat aatcttcttt tgttcaaata aaaagtttct 1920
tcttatggac taaaaaaaaa aaaaaaaaaa aaa                              1953

<210> 563
<211> 1755
<212> DNA
<213> Cichorium intybus

<220> 
<223> germacrene A synthase short form

<400> 563
atcaaactta gctatatcct ttcaccttca agaaatggca gcagttgaag ccaacggtac 60
cttccaagca aacaccaaaa ccacagagcc ggtgcgtcct ttagccaact tccctccttc 120
tgtatggggt gatcgattct tgtcattctc tcttgacact acggaattgg aaggatatgc 180
aaaagctatg gaggagccaa aagaagaagt gagaaaactg atcgtagatc caacaatgga 240
ttcaaataag aaactaagtt tgatttattc tgtacaccgt cttggtttga catatctgtt 300
cttgcaagag attgaagcgc agcttgacaa actatttaaa gagtttaact tgcaagatta 360
tgatgagttt gatctataca caacttctat taactttcaa gttttcagac accttggtca 420
caaactgcca tgtgatgtgt ttaacaaatt caaggacagt agctcgggta cattcaagga 480
atccattacc aacgatgtga agggtatgtt aggcttatat gaatctgcac aattgagatt 540
aagaggagaa cccattctcg atgaagcttc cgcattcact gaaactcaac tcaagagtgt 600
agtaaacact ctcgaaggca atcttgcaaa acaggtgatg caatcattga ggagaccatt 660
ccatcagggg atgccaatgg ttgaggcaag gatgtatttc tccaactatg atgaagaatg 720
ttccacacac gagtcattac ctaagcttgc aaagcttcat ttcaactatt tgcagctaca 780
acaaaaggaa gaacttcgca ttgtctcaaa gtggtggaag gatatgaggt tccaggaaac 840
tactccttac ataagggata gagtaccaga gatttactta tggatattgg gattgtactt 900
tgagcctcgt tactccttgg cacgaatcat cgccacaaaa attacattgt tcctcgtggt 960
tctagatgac acatatgatg catacgctac cattgaagag attcgacttc tgactgatgc 1020
cataaacagg tgggacatca gtgctatgga gcaaattccg gaatatattc gaccattcta 1080
caaaattctc ctagatgagt atgctgaact tgagaagcaa ctagctaaag aaggaagagc 1140
aaaaagtgtt attgcttcaa aagaagcgtt ccaggacatt gcaagaggat accttgaaga 1200
ggccgagtgg acaaacagtg gatacgtggc atcatttcca gagtatatga agaacggttt 1260
aattacttct gcttacaatg ttatttcaaa atctgcttta gtgggtatgg gcgagatggt 1320
tggtgaagat gccttggctt ggtatgaaag tcatccaaag acattgcaag cttcagagtt 1380
aatttcaaga ctccaagatg atgtgatgac ttaccagttt gagcgagaaa ggggacaatc 1440
agccaccggc gttgattctt atatcaagac ctatggcgta acagaaaagg aagcgattga 1500
cgagctaaac aaaatgattg aaaatgcatg gaaggatata aatgagggct gccttaagcc 1560
aagagaagtc tcaatggatt tgcttgcccc aattcttaat cttgcacgaa tgatagatgt 1620
ggtatacagg tacgacgatg ggttcacttt tccgggaaag accatgaaag agtatattac 1680
tctgttgttt gttggttctt cacccatgta ataataattt ttatttcata tgtttaaaaa 1740
aaaaaaaaaa aaaaa                                                  1755

<210> 564
<211> 2005
<212> DNA
<213> Cinnamomum tenuipile

<220> 
<223> geraniol synthase

<400> 564
ctcttctata tgtaatgcct atgggcattt cggtttctta tcaacaaatt ggaacatggc 60
attgcaaatg attgctccat ttctatcctc cttcctccca aatcccagac acagcctcgc 120
agcccatggc ctcacacacc agaaatgtgt ctcaaagcac atttcatgct ccaccactac 180
accaacctac tcaaccacag ttccaagaag atcagggaac tacaagccca gcatctggga 240
ctatgatttt gtgcagtcac taggaagtgg ctacaaggta gaggcacatg gaacacgtgt 300
gaagaagttg aaggaagttg taaagcattt gttgaaagaa acagatagtt ctttggccca 360
aatagaactg attgacaaac tccgtcgtct aggtctaagg tggctcttca aaaatgagat 420
taagcaagtg ctatacacga tatcatcaga caacaccagc atagaaatga ggaaagatct 480
tcatgcagta tcaactcgat ttagacttct tagacaacat gggtacaagg tctccacaga 540
tgttttcaac gacttcaaag atgaaaaggg ttgtttcaag ccaagccttt caatggacat 600
aaagggaatg ttgagcttgt atgaagcttc acaccttgcc tttcaagggg agactgtgtt 660
ggatgaggca agagctttcg taagcacaca tctcatggat atcaaggaga acatagaccc 720
aatccttcat aaaaaagtag agcatgcttt ggatatgcct ttgcattgga ggttagaaaa 780
attagaggct aggtggtaca tggacatata tatgagggaa gaaggcatga attcttcttt 840
acttgaattg gccatgcttc atttcaacat tgtgcaaaca acattccaaa caaatttaaa 900
gagtttgtca aggtggtgga aagatttggg tcttggagag cagttgagct tcactagaga 960
caggttggtg gaatgtttct tttgggccgc cgcaatgaca cctgagccac aatttggacg 1020
ttgccaggaa gttgtagcga aagttgctca actcataata ataattgacg atatctatga 1080
cgtgtatggt acggtggatg agctagaact ttttactaat gcgattgata gatgggatct 1140
tgaggcaatg gagcaacttc ctgaatatat gaagacctgt ttcttagctt tatacaacag 1200
tattaatgaa ataggttatg acattttgaa agaggaaggg cgcaatgtca taccatacct 1260
tagaaatacg tggacagaat tgtgtaaagc attcttagtg gaggccaaat ggtatagtag 1320
tggatataca ccaacgcttg aggagtatct gcaaacctca tggatttcga ttggaagtct 1380
acccatgcaa acatatgttt ttgctctact tgggaaaaat ctagcaccgg agagtagtga 1440
ttttgctgag aagatctcgg atatcttacg attgggagga atgatgattc gacttccgga 1500
tgatttggga acttcaacgg atgaactaaa gagaggtgat gttccaaaat ccattcagtg 1560
ttacatgcat gaagcaggtg ttacagagga tgttgctcgc gaccacataa tgggtctatt 1620
tcaagagaca tggaaaaaac tcaatgaata ccttgtggaa agttctcttc cccatgcctt 1680
tatcgatcat gctatgaatc ttggacgtgt ctcctattgc acttacaaac atggagatgg 1740
atttagtgat ggatttggag atcctggcag tcaagagaaa aagatgttca tgtctttatt 1800
tgctgaaccc cttcaagttg atgaagccaa gggtatttca ttttatgttg atggtggatc 1860
tgcctgatta aatgtagtaa atgtaaaatc ggatattaaa tttgcctaga catgttatga 1920
atatttagat gtgcttccat gatatatata ctaataaatt agttctggta gcttaccatg 1980
agcaataaaa aaaaaaaaaa aaaaa                                       2005

<210> 565
<211> 1719
<212> DNA
<213> Cistus creticus

<220> 
<223> germacrene B synthase

<400> 565
atgtttaccc aaacatcatt atcatcatca gctccagctc tttcaaccca aaatgccaaa 60
cctgaaatcg ttcgtcgatc cgccggcttt catcccagca tttggggtga tcaattcctt 120
tcatatgcct ccaatcctgt ggttgaaaac gaagaagaga aaagggagca tgatttgctc 180
aaaggaaaac tcaaggagaa gctaatgact gccgctgaga ataagtcatt gattgaggat 240
aaggagacac ttgatttgat tgatctaatt cagagattgt gtgtctctta ccattttgaa 300
aaggagatta gccgcatctt ggaacaaatt atgcagctag tgacccacaa cgaccacgac 360
cacaaccacg atgatggaga cctgtatacc acttccctta ggtttcgtct cctacgacaa 420
aatggttata gaattccttg cggtgttttt aacaagttta aagatagtga agggaacttc 480
aaggaatcct tgatttgcga tgttaaagga atgttaagtt tgtacgaggc tgcacatcta 540
aggattcaag gagaagatat tcttgatgag gcattgtctt tcactagcac acagcttggt 600
gctgcaaaga ccaccatcac caccacaaac ccttctcttg cagctcaagt ggctcatgct 660
ttaaaacaac ctatccgtaa gggcttgcca aggcttcaag ctaggcggtt catgccagtt 720
tatgaggctg atccttgtca tgacaaaacc ttattaacct tcgcaaagtt ggatttcaat 780
atgttacaaa gactgcacca aaaagaagtc ggtgaaatta caaagtggtg gaaagatata 840
gacttctcaa acaagatgcc ttttgccaga gacagagttg tagaatgtta cttttggacc 900
ttaggagtgt attttgagcc aaaatacaca ttgggtcgaa agatttttaa caaagtaata 960
gcaatgactt ctgttcttga tgacatttat gatgtttatg gaacccttga tgaacttgag 1020
atatttacag aagctatcct gaggtgggat atcaatacaa taagtcaact tccaagttac 1080
atgcaaattt attatcaagc atttattgat gtttatagtg aaatggaggc acaaatggaa 1140
gtagaagaca aattatactg cgttccttat gcaaaagaag ttatgaaaaa actagtcagg 1200
gcataccacc aagaatcaaa atggttccat gcgaattatg tgccgccgat ggaggagtac 1260
atgtccgttg cattggttag ctccggttat gaagtgcttg ccgccacatc ctttgttgga 1320
atgggagatg tcgtcaccaa agactctttt gagtggttgt tcaattaccc caagataatc 1380
actgcttctc taattatggg tagactcatg aatgatattg taggtcacaa gtttgagcaa 1440
aagagaggtc atgtagcttc ggctgttgaa tgttacgtga aacaatacgg aggaacagaa 1500
gaagaagccg tagaggaatt tcggaaacaa attaccaatg catggaagga tatcaatgag 1560
gaatgcttat gcccaacggc agtgccgatg cctctcctta ctcgcgtact caaccttgcg 1620
agagttcttg aagtcattta caatattgat gattgctaca caaattccaa actcatagtc 1680
aaggacattg cttctctgct catcaatccg gtcccatga                        1719

<210> 566
<211> 1867
<212> DNA
<213> Citrus junos

<220> 
<223> (E)-beta-farnesene synthase

<400> 566
caactcctac tcttaaaaac aaactatata gttgtatttg gtttgtctga aacggaatga 60
aagatatgtc tattccactt ctagcagcag tttccagttc aactgaagaa actgttcgtc 120
ccattgcaga ttttcatcct accttatggg gaaaccattt cctgaaatcc gctgccgatg 180
tcgagacaat tgacgctgca actcaagaac agcacgcagc actgaagcaa gaggtcagga 240
ggatgataac cactactgcc aataagcttg cccaaaaact acacatgatt gatgcagtac 300
aacgattagg tgtcgcttat cattttgaaa aagagattga agatgaattg ggaaaggtat 360
ctcacgatct tgacagtgat gatctatacg ttgtttctct tcgttttcga ctttttagac 420
agcaaggagt taagatttca tgtgatgtgt ttgataagtt caaagatgat gaaggtaaat 480
tcaaggaatc attgatcaac gatatacgag gcatgttgag tttgtacgag gcagcatacc 540
tagcaattcg gggggaagac attttagatg aagccattgt tttcactacc actcacctta 600
agtcagtaat atctatatct gatcattctc atgcaaactc taatcttgct gaacaaatac 660
gtcattctct gcaaattcct ctccgtaaag ccgcagcaag gttagaggca aggtattttt 720
tggatatcta ttcaagggat gatttgcatg atgaaacttt gctcaagttt gcaaagttag 780
actttaatat attacaagca gcacaccaga aggaagcaag tatcatgacc aggtggtgga 840
acgatttagg cttccctaaa aaggtgcctt atgcaagaga tagaataata gagacatata 900
tctggatgtt gctgggagtg tcctatgagc ccaatttggc atttggtaga atttttgcat 960
ccaaagtggt gtgcatgata accacaatag acgacacatt tgatgcttac ggtacttttg 1020
aagagctcac actttttact gaagcagtca caagatggga cattggcctc atagatacac 1080
tgccagaata catgaaattt attgtcaagg cactcttaga tatttataga gaagctgagg 1140
aagaattggc aaaggaagga agatcgtacg gcataccata tgcaaaacag atgatgcaag 1200
aattaattat attgtacttt accgaagcca agtggttata taaaggttat gttccaacct 1260
tcgatgaata caaatcagtt gcattaagaa gtatcggttt acgtacgcta gcggtcgctt 1320
ccttcgttga tttgggtgat tttattgcaa cgaaggacaa ttttgaatgc attcttaaaa 1380
acgctaagag tcttaaagcg acagaaacca ttggcaggct catggatgac atagcaggtt 1440
ataagtttga gcagaagaga ggacataatc cctcagcagt tgagtgctac aagaatcaac 1500
atggcgtctc cgaggaagag gcagttaaag aattgttgtt agaagttgct aacagttgga 1560
aagatataaa tgaggagctt ctcaacccaa cgactgtccc gttacctatg cttcaacggc 1620
ttctttattt cgcacgttca ggccatttta tctacgacga tggtcatgat cgctacaccc 1680
attcattgat gatgaaacgc caagttgcct tgttgctgac ggaacccctt gcgatctgaa 1740
gattaacgtc atgctgttga ttttccatcg ggtatatttg agcagttgta ataaatgaag 1800
gtcgcgctgg ctatttagct agctactcat gcctggctaa taaatgtgtc gccaataata 1860
tggtttc                                                           1867

<210> 567
<211> 1900
<212> DNA
<213> Citrus junos

<220> 
<223> terpene synthase

<400> 567
cgtgggtgaa gtaatcagtt cctttggttt gagtgtgaaa aagaaaaaaa aaatgtccgc 60
tcaagttcta gcaacggttt ccagttcgac agaaaaaact gttcgtccca ttgctggttt 120
ccatcctaac ttatggggag actatttcct gaccctcgct tctgattgca agacagatga 180
tactacgcac caagaggaat acgaagcgct gaagcaagaa gtcagaagca tgataacggc 240
tacggcagat acacctgccc agaagttgca attggttgat gcagtccaac gattgggtgt 300
ggcctatcac ttcgaacagg agatagaaga tgcaatggaa aagatttatc acgatgactt 360
tgataataac gatgatgtcg atctctacac tgtttctctt cgttttcgac tgcttaggca 420
gcaaggattt aaggttccgt gtgatgtgtt cgcgaagttc aaagatgatg aaggtaaatt 480
caaggcatca ttggtgcggg atgttcatgg cattctaagt ttgtatgagg caggacactt 540
ggccattcgc ggagaaggga tattagatga agccattgct ttcactagaa ctcaccttca 600
gtcaatggta tctcaggatg tatgccctaa taatcttgct gaacaaatta atcatactct 660
cgactgtcct ctccgcagag cccttccaag agtggagaca agatttttct tgtcggtcta 720
tccaagagat gataaacacg ataaaacttt gttaaagttt tcaaagttag actttaacct 780
tgtgcaaaga atacatcaga aggaattaag tgccatcaca cggtggtgga aagatttaga 840
cttcactaca aagctacctt atgcaagaga cagaatcgta gagttgtatt tttggattgt 900
agggacgtat tttgaaccaa agtacacttt agcaagaaaa ataatgacca aaacaattta 960
cacggcatct atcatagatg acactttcga cgcttatggc ttctttgaag agctcaaact 1020
ctttgcagaa gcagtccaga ggtgggacat tggagccatg gatatacttc cagaatacat 1080
gaaagtgctt tataaggccc ttttagatac tttcaatgaa attgagcaag acttggccaa 1140
ggaaggaaga tcgtcctgct taccttatgg caaagaaaag atgcaagagc ttgttcaaat 1200
gtactttgtt caagccaagt ggttcagtga aggttatgtt ccgacatggg acgaatatta 1260
tccggttgga cttgtaagtt gcggctactt catgcttgcg acaaattcct tccttggcat 1320
gtgtgatgtt gcaaacaagg aatcttttga atggatatcc aggaccctaa gatttcaaca 1380
gcgtcatcag tttatctgca gacttaggaa tgacattgtt tcccaccagt ttgaacagaa 1440
gagaggacat attgcctcag gagttgaatg ctacattaag cagtatggtg tttcagcaga 1500
agaggtagtt acagttttta ctgaagaagt tgagaatgca tggaaagata tgaatgagga 1560
attcctgaaa ccaactgctt ttcctgtggc tttgattgag agacctttca atatcgcacg 1620
tgtgattgaa tttctaaaca agaagggtga ttggtacact cattctcatg cgattaaaga 1680
ccagattgcc gcagtgctca gagaccctgt taccatctga agagttataa gtatttctgt 1740
cagttacatt tcatggtgtt ttcagaataa atggtgtttg tatcaaggga ttgagttact 1800
cttcatctcc tgctgtttgg gataaaatgt aaaagagatt gggttatcgt tgatctctga 1860
tgtgccgtgt gcggaataaa ttgtattttg atccactact                       1900

<210> 568
<211> 2043
<212> DNA
<213> Citrus limon

<220> 
<223> (+)-limonene synthase 1

<400> 568
ggccaagtat aactgtaagc tagcttacac tacatctgta tatccaatgt cttcttgcat 60
taatccctca accttggtta cctctgtaaa tgctttcaaa tgtcttcctc ttgcaacaaa 120
taaagcagcc atcagaatca tggccaaata taagccagtc caatgcctta tcagcgccaa 180
atatgataat ttgacagttg ataggagatc agcaaactac caaccttcaa tttgggacca 240
cgattttttg cagtcattga atagcaacta tacggatgaa gcatacaaaa gacgagcaga 300
agagctgagg ggaaaagtga agatagcgat taaggatgta atcgagcctc tggatcagtt 360
ggagctgatt gataacttgc aaagacttgg attggctcat cgttttgaga ctgagattag 420
gaacatattg aataatatct acaacaataa taaagattat aattggagaa aagaaaatct 480
gtatgcaacc tcccttgaat tcagactact tagacaacat ggctatcctg tttctcaaga 540
ggttttcaat ggttttaaag acgaccaggg aggcttcatt tgtgatgatt tcaagggaat 600
actgagcttg catgaagctt cgtattacag cttagaagga gaaagcatca tggaggaggc 660
ctggcaattt actagtaaac atcttaaaga agtgatgatc agcaagaaca tggaagagga 720
tgtatttgta gcagaacaag cgaagcgtgc actggagctc cctctgcatt ggaaagtgcc 780
aatgttagag gcaaggtggt tcatacacat ttatgagaga agagaggaca agaaccacct 840
tttacttgag ctcgctaaga tggagtttaa cactttgcag gcaatttacc aggaagaact 900
aaaagaaatt tcagggtggt ggaaggatac aggtcttgga gagaaattga gctttgcgag 960
gaacaggttg gtagcgtcct tcttatggag catggggatc gcgtttgagc ctcaattcgc 1020
ctactgcagg agagtgctca caatctcgat agccctaatt acagtgattg atgacattta 1080
tgatgtctat ggaacattgg atgaacttga gatattcact gatgctgttg agaggtggga 1140
catcaattat gctttgaagc accttccggg ctatatgaaa atgtgttttc ttgcgcttta 1200
caactttgtt aatgaatttg cttattacgt tctcaaacaa caggattttg atttgcttct 1260
gagcataaaa aatgcatggc ttggcttaat acaagcctac ttggtggagg cgaaatggta 1320
ccatagcaag tacacaccga aactggaaga atacttggaa aatggattgg tatcaataac 1380
gggcccttta attataacga tttcatatct ttctggtaca aatccaatca ttaagaagga 1440
actggaattt ctagaaagta atccagatat agttcactgg tcatccaaga ttttccgtct 1500
gcaagatgat ttgggaactt catcggacga gatacagaga ggggatgttc cgaaatcaat 1560
ccagtgttac atgcatgaaa ctggtgcctc agaggaagtt gctcgtcaac acatcaagga 1620
tatgatgaga cagatgtgga agaaggtgaa tgcatacaca gccgataaag actctccctt 1680
gactggaaca actactgagt tcctcttgaa tcttgtgaga atgtcccatt ttatgtatct 1740
acatggagat gggcatggtg ttcaaaacca agagactatc gatgtcggtt ttacattgct 1800
ttttcagccc attcccttgg aggacaaaca catggctttc acagcatctc ctggcaccaa 1860
aggctgatga tgaattataa tgcatgatgc gttgcgaatt cccagagagt gcagtttcag 1920
ttgatgttgg cctccacttt tctttcttct gagggatctc ttttcgataa taaaataaat 1980
tccctcattc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2040
aaa                                                               2043

<210> 569
<211> 1991
<212> DNA
<213> Citrus limon

<220> 
<223> gamma-terpinene synthase

<400> 569
atagaatcct tgaaattata ttctaagtca tggctcttaa cctgctatct tcactacctg 60
cggcatgcaa tttcaccaga ttatcattac cattatcaag caaagttaat ggctttgttc 120
ctcctattac tcaagtccaa tatcccatgg ctgcatccac ttcttctatt aagcctgtcg 180
atcaaaccat tattaggcga tctgccgatt acgggccaac catttggagt tttgattata 240
ttcaatcact tgacagtaaa tataaaggag aatcgtatgc cagacaattg gaaaagctga 300
aggaacaagt aagcgcgatg ctacagcagg ataataaagt ggtggatttg gatcctttac 360
atcaacttga gctcatcgat aatctgcaca gacttggagt atcttatcac tttgaggatg 420
aaataaaaag aactttggat aggatacaca acaagaatac taataaaagt ttatatgcca 480
gagcactcaa atttagaatc ctaaggcaat atggttacaa aacccctgta aaagaaactt 540
tttcacgttt catggatgag aaggggagct ttaagttatc aagccacagt gacgaatgca 600
aaggaatgtt agctctgtat gaagctgcat acctcctggt agaagaagaa agcagtatct 660
ttcgtgacgc tataaggttc accaccgcat atctcaaaga atgggtggcc aagcatgata 720
ttgacaaaaa tgataatgaa tatctttgta cattagtgaa acatgctttg gaacttccac 780
tacattggag gatgcgaaga ttggaggcaa ggtggttcat cgatgtatac gaaagtggac 840
cggacatgaa ccctatcttg ctcgagcttg ctaaagttga ctataatatt gtgcaagcag 900
tacaccaaga ggatctcaaa tatgtgtcaa ggtggtggaa gaaaacagga cttggggaga 960
agttgaattt tgcaagagac agagtagtgg agaatttctt ctggactgtg ggggatatat 1020
tcgaacctca gtttggatat tgtagaagga tgtctgcaat ggttaattgt cttttaacat 1080
caatcgatga tgtttatgat gtctatggga ccttggacga acttgagcta ttcactgatg 1140
cagttgagag atgggacgct actacaacag agcaacttcc gtactatatg aagctgtgct 1200
ttcatgctct ctataattcc gtaaatgaaa tgggttttat tgctcttaga gatcaagaag 1260
ttggcatgat cattccttat cttaagaaag cgtgggcaga tcaatgcaaa tcatatttag 1320
tggaggcaaa gtggtacaac agcggctaca taccaactct tcaagaatat atggaaaacg 1380
cttggatttc agtaacagca cctgtaatgc tactccatgc gtatgctttt acagcaaatc 1440
caataacaaa ggaggccttg gaattcttgc aggattctcc cgatataatt cgtatttcat 1500
caatgattgt acgacttgaa gacgatttgg gaacatcatc ggatgagctg aagaggggag 1560
atgttcccaa atcaattcaa tgttacatgc atgaaactgg agtttcagag gatgaggctc 1620
gtgaacatat acgagatttg attgctgaga catggatgaa gatgaacagt gctcgattcg 1680
gaaacccacc ttacttgccc gatgttttta ttgggattgc aatgaatttg gtgaggatgt 1740
ctcaatgcat gtacctatat ggagatggac acggtgtaca agaaaatacc aaggatcgtg 1800
tgttgtcttt atttattgat cccattcctt aattatgaaa atttctcata ataaggattt 1860
acagtcatgt actagatctc ccaaataaac atgcagttgc gtactataag actcattact 1920
gtggtcacca aatcgttcct cctcataata aataaatatt atttgaagtc tctaaaaaaa 1980
aaaaaaaaaa a                                                      1991

<210> 570
<211> 1647
<212> DNA
<213> Citrus sinensis

<220> 
<223> terpene synthase 1

<400> 570
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaatctata ttgacagtaa tagagctgat 300
ctccacaccg tttcccttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatca attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 571
<211> 1877
<212> DNA
<213> Citrux x paradisi

<220> 
<223> putative terpene synthase

<400> 571
aatacaaatt ataattccac agaaatatca aaattctgcg gcacccgttt gtctgacaca 60
aaaatgtcgt ctggagaaac atttcgtcct actgcagatt tccatcctag tttatggaga 120
aaccatttcc tcaaaggtgc ttctgatttc aagacagttg atcatactgc aactcaagaa 180
cgacacgagg cactgaaaga agaggtaagg agaatgataa cagatgctga agataagcct 240
gttcagaagt tacgcttgat tgatgaagta caacgcctgg gggtggctta tcactttgag 300
aaagaaatag aagatgcaat actaaaatta tgtccaatct atattgacag taatagagct 360
gatctccaca ccgtttccct tcattttcga ttgcttaggc agcaaggaat caagatttca 420
tgtgatgtgt ttgagaagtt caaagatgat gagggtagat tcaagtcatc gttgataaac 480
gatgttcaag ggatgttaag tttgtacgag gcagcataca tggcagttcg cggagaacat 540
atattagatg aagccattgc tttcactacc actcacctga agtcattggt agctcaggat 600
catgtaaccc ctaagcttgc ggaacagata aatcatgctt tataccgtcc tcttcgtaaa 660
accctaccaa gattagaggc gaggtatttt atgtccatga tcaattcaac aagtgatcat 720
ttatacaata aaactctgct gaattttgca aagttagatt ttaacatatt gctagagccg 780
cacaaggagg aactcaatga attaacaaag tggtggaaag atttagactt cactacaaaa 840
ctaccttatg caagagacag attagtggag ttatattttt gggatttagg gacatacttc 900
gagcctcaat atgcatttgg gagaaagata atgacccaat taaattacat attatccatc 960
atagatgata cttatgatgc gtatggtaca cttgaagaac tcagcctctt tactgaagca 1020
gttcaaagat ggaatattga ggccgtagat atgcttccag aatacatgaa attgatttac 1080
aggacactct tagatgcttt taatgaaatt gaggaagata tggccaagca aggaagatca 1140
cactgcgtac gttatgcaaa agaggagaat caaaaagtaa ttggagcata ctctgttcaa 1200
gccaaatggt tcagtgaagg ttacgttcca acaattgagg agtatatgcc tattgcacta 1260
acaagttgtg cttacacatt cgtcataaca aattccttcc ttggcatggg tgattttgca 1320
actaaagagg tttttgaatg gatctccaat aaccctaagg ttgtaaaagc agcatcagtt 1380
atctgcagac tcatggatga catgcaaggt catgagtttg agcagaagag aggacatgtt 1440
gcgtcagcta ttgaatgtta cacgaagcag catggtgtct ctaaggaaga ggcaattaaa 1500
atgtttgaag aagaagttgc aaatgcatgg aaagatattg acgaggagtt gatgatgaag 1560
ccaaccgtcg ttgcccgacc actgctcggg acgattctta atcttgctcg tgcaattgat 1620
tttatttaca aagaggacga cggctatacg cattcttacc taattaaaga tcaaattgct 1680
tctgtgctag gagaccacgt tccattttga cgactagttc tatacttcta ttaataatat 1740
tttcagttcc ttggtttgtg tttaaaggaa atacggtgta tcgtattggt ctgtactaat 1800
aaatatttta tatttttatt gttacttaaa gattttccct tcgaataaaa aaataaactc 1860
taatataaaa aaaaaaa                                                1877

<210> 572
<211> 1837
<212> DNA
<213> Crepidiastrum sonochifolium

<220> 
<223> germacrene A synthase

<400> 572
aaccaacctc aaaatagtca ccaatcaaca aatcgagctt aaaacatctc cattcaatta 60
cttcacaaaa tggcagcagt tgaagccaat ggtacccttc aagcaaacac caaaaccacc 120
actgagcctg ttcgcccttt ggccaatttc cctccttctg tatggggtga tcgtttcttg 180
tcattctctc ttgacaataa ggaattggaa ggatatgcaa aagccatgga ggagcccaaa 240
gaagaattga gaagattgat tgtggattca acaatggatt ccaacaagaa actaagtttg 300
atatattcgg tacaccgtct tggtttgaca tatcttttct tgcaagagat tgaagcacaa 360
cttgagaaac tcttcaaaga gtttaacctg caagattatg atgaagttga tctatacaca 420
acttctatta actttcaagt tttccgacac cttggtcaca aacttccttg tgatgtgttt 480
aacaaattta aagacagtac ctcgggtaaa ttcaaggaat acatcaccaa cgatgtgaag 540
ggtatgttag ggttatatga atctgcacaa ttgcgagtta gaggtgaatc gattctagat 600
gaagcttcag ctttcactga aactaaactc aaaagtgttg taaacactct agaaggaaag 660
cttgaagaac aagtgatgca atcattgagg agaccatttc atcaagggat gccaatggtg 720
gaagcaaggc tatatttctc caactatacc gaagaatgtg caacacatgc atctttacta 780
aagcttgcaa agttgcattt tagctatctg gagcttcaac agaaggaaga acttcgtatc 840
gtgtcacagt ggtggaaaga tatggagttt cagacatcgg tcccttacat aagagataga 900
gtaccggaga tatacctatg gattttggga ttgtactttg agcctcgtta ctcattggca 960
cgaatcatcg ccacaaaaat tacattgttt cttgtggtgc tagatgacac atatgacgcg 1020
tatgctacca ttgaagaaat tcgccttctt acggacgcca taaataggtg ggacattagt 1080
gccatggagc aaattccgga atatattcga ccattttaca agattctcct cgaggagtat 1140
gctgaacttg agaaacagct agctaaggaa ggaagagaaa aaagtgttat tgcttcaaaa 1200
caagcgttcc aagacattgc taacggctac cttgaagagg ccgagtggac aaacagtgga 1260
tatgtggcaa catttccaga gtatatgaag aacggtttaa ttacttctgc gtacaatgtt 1320
atttcaaaat cagctttggt gggtatgggt gagatggtta gtgagcatgc tttggcttgg 1380
tatgaaagtc atccaaagac attgcaagct tcggagttaa tttcaagact ccaagatgac 1440
gtcatgactt accagtttga gcgagaaagg gggcaatcag ccactggcgt tgattcttat 1500
atcaagacgt atggcgtttc agagaaggaa gctattgacg agctcaataa aatgattgaa 1560
aatgcgtgga aggatataaa cgagggctgt ttgaagccaa gagaagtttc catggatgtg 1620
cttgcaccga ttcttaatct tgcacgaatg atagatgtgg tatataggta cgacgatggg 1680
ttcacttttc ccggaaagac catgaaagag tatactactc tattgtttgt aggttcttca 1740
cccatgtaat aataaaatat tgaatgttgt ttcttatgtt tatgatattt ttcgatgaat 1800
aataaatatt ttatcgaccg gtaaaaaaaa aaaaaaa                          1837

<210> 573
<211> 2490
<212> DNA
<213> Croton sublyratus

<220> 
<223> copalyl diphosphate synthase

<400> 573
atgtcttctc aggcgttctc tcttctgtct tcccttcctt cctcttcttt ttctagcact 60
cgtcctcgtc ttttcctagg tgtttggtac gagcttcaag gccagcggat aagctttaat 120
cttcgcccaa gatgcactga cttatccatc acttacacta acgaatatgt ccacggagaa 180
atggcagtga ttaacccgcc ggaagatgat acagaagagc aagtacctaa ggtgacgaat 240
tccatttgcg tgaaatttaa taataaagaa aaaaagagct acatttatga ttatgagtat 300
aatttgattt taaagttgtt gattaaggtt gcgatatcaa aagagataat gagaagtgta 360
gagagaatta aaaagatgct gaaatccatg gaggatggag aaataaacat atcagcatat 420
gatacagctt gggtacgtct agttaaagat gtaaatggaa gtggagaacc tcaattccca 480
tcagctcttc agtggatttc aaataatcaa ttaccagatg ggtcttgggg tgatgctctt 540
gtttttaatg cgcatgatcg tattctcagt actctggctt gtgttgtcac tctcaagtcc 600
tggaatttac accctcataa ggttgcaaaa ggtctgaaat tttttaaaga aaatctgagc 660
aaacttgaag aggagaacga ggagcacatg tctattggat ttgaagtggt ttttccttca 720
cttctggagc ttgcaaggaa attagacatt gacgttcctg atgattctca tgtcttacaa 780
cagatttgtg aatgcagaaa tacgaagctc aaaaagatac ccaaagatat aatgcacaaa 840
atgcccacct cactactcca tagcttggaa ggaatgcctg atcttgagtg ggaaaagctc 900
ttaaaattac agttcgacaa tggctccttc ctcttctctc cttcctccac tgcttacgct 960
ttcatgcaaa ctcaagatga taaatgttta atctatttaa acaggattgt ccaaagattt 1020
aatggtggag taccgaatgt ttatccagtt gatcttttcg agcacacttg ggctgctgat 1080
cgcttgcaac gccttggaat ctcgagatta tttgagcaag agcttaaaga atgtatgaat 1140
tacgtcgcta gatattggag agaagatggg atgtgctggg cgagaaattc taatgttcgt 1200
gatgttgatg actcgtcgat gggattcaga atgcttagat tatatggtca taatgtttct 1260
gcggatgtgt tcaagaaatt caaaaaagat gatacttggg tctgcatgcc tggacaatca 1320
acgcaggcca ttaccggaat gtataatttg tttcgagctt ctcaggttct atttccagga 1380
gaaatgattc ttgaagaagc tagggaattt tgttatgatt tccttaggga aaagcaatct 1440
gctaatgcag tcgtagataa atggattatt tccaaggatt taccaggaga ggttgcatat 1500
gcgttggatg tgccatggtt tgccagctta cctacagttg aggcaagatt ctatattgaa 1560
caatacggtg gagatgatga tgtatggatt ggtaaggttc tgtatagaat gccatttgtg 1620
aataacaatg agtatttgga acttgctaag tttgactaca atagttgcca agcactgcac 1680
cgtgctgaat gggacaattt tcaaaagtgg tatgatgaat gtaatttggg ggattttggg 1740
gtaagtaaaa gagagcttct actagcatat tacataagcg cagcaagcat ttttgagcca 1800
gaaaagtcta aagaaaggct tgcatgggcc aaaactagta ttttgctaca aactattgat 1860
gcttatttcc acaccaacaa ctccattgag gagaggaaag atttcgtaca ccaatttaac 1920
atggagctcc tgctccctca cttggaatgg aatagacagg aaaatggaag agaagacaaa 1980
gcaggaactt gtcggaatta tacttggaac cttaaacgat gtcccttgga tgcactggtg 2040
gctcatggca cagacattag tcacagtttg cgtcatgctt gggaaattgg gctcacaaat 2100
tgggaaaaag atggagacaa gcaccgcgga aaagcggaac ttattgtgaa aactattaat 2160
ctaacaactg gtccttgggt gtccgaagaa cttttaaact gtaattctaa atatgaaaag 2220
ttgtttcaac tttctaatta tttgtaccat cagcttggtc attttaacaa aaacaaggtg 2280
gatgataaaa agaaatacac aactccagaa atagagtcaa gcatgcagga attggctcaa 2340
ttggtgctcc aaaattcatc agacggactt gattctaata tcaagcaaac tttctttaca 2400
gtggttaaaa gtatttacta cactactgtt tgcgatctcg gaactaccaa ttaccatatg 2460
tccaaagtgc tctttgaaag agtatattaa                                  2490

<210> 574
<211> 1716
<212> DNA
<213> Cucumis melo

<220> 
<223> delta-cadinene synthase

<400> 574
atgtcttctc aagtttcaaa ttttcctgct tccattatga aaaccaatga tattcctgat 60
gttaagcgtt ctcttgcaaa ttttcatcct aatatttgga aggaacattt cctttcattt 120
acatttgatg atgcattgaa aatagatgag ggcatgaaag aaagaactga aaagttgaaa 180
gaagaaataa gaatgatgat gattgcttat gtggaaaatc aactgattaa gctaaatttg 240
gttgattcaa tccaacggct aggagtatcc tatcattttg aagatgaggt tgatgaattc 300
ttagaacata tatatgtgtc ttataataat tcccttttat tgagtaataa aaatagtaat 360
ggtgaagatc ttcatattac tgctcttcta tttcgacttc tgaggcaaca aggttatagg 420
atttcatgtg atatattttt gaagttcatg gacgacaatg gaaaattcaa agagtcactg 480
gttgaggatg aaagaggatt attgagccta tatgaagcat cacatatgat gggacatgga 540
gaagctttgc tcgaggaagc tcttgaattt acaaccacac atcttcaaac atatattcat 600
cgttactcaa atattaatcc aagttttgca tctgaagtta gtaatgcatt gaaattgcct 660
attagaaaaa gtgttccaag aatcaaggca agagagtatt tggaaattta ccaacaacat 720
ccttctcaca atgagacttt gcttgaattc tcaaaactag acttcaacat attacaaaaa 780
cttcatcaaa aggagctaag tgaaatctgc aggtggtgga aggatttgga tgttccaaca 840
aagtttcctt ttgcaagaga tagaattgtg gagtgttatt tttggacgtt gggagcatac 900
tttgaacctc aatacagtgt tgggaggaaa atgttaacaa aagtaattgc aattgcttca 960
attttagatg atatttatga tgcctatgga acatttgaag aactccaagt gctcactcca 1020
gcaattcaaa ggtgggatag aagcatggtg catacacttc ctctgtacat gaaacctttt 1080
tatgtagcaa tgttagaact ttatgaggaa attggcaaag agattgacaa ggatcaaaat 1140
tctctccacc ttcaagttgc aataggagga ataaaaaggc tatctgaatc ctattttgaa 1200
gaagctaaat ggttaaataa ggagtataaa ccaagtttca aggagtacat ggaactggca 1260
ttaaagacca caggttatac catgcttata tccatttctt ttcttggatt gggtgatcac 1320
attgtaacaa acgaggttct tcaatggctt tcaaatggac ctcaaattat taaagcctcg 1380
accatcattt gtagactcat ggacgacatc gcttcccaca agtttgaaca agaaagggag 1440
catgtagctt ctgctgttga atgttacatg aagcaatatg attgttcaga agaagaagct 1500
tgcattgaac ttcataagga agtggttgat gcatggaagg atacaaacga agcattttat 1560
cgtccattta atgttccagt tccagttcta atgcgcgtac tcaatttttc aagagttata 1620
aacttgcttt atttggatga agatggatac acaaatgcaa agagtggaac aaagtttctt 1680
attaaatctc ttcttgttga cccactgcct tgttaa                           1716

<210> 575
<211> 1683
<212> DNA
<213> Cucumis melo

<220> 
<223> alpha-farnesene synthase

<400> 575
atgagttcaa acatatcagc aattccaaac tctttggagg tgattcgaag gtctgcacaa 60
tttcaagcaa gtgtttgggg agactatttt ctttcctatc attctctttc tccggaaaaa 120
ggcaacaagg tgatggaaaa acaaacggaa gaattgaaag aagaaataaa aagggagttg 180
aattctacaa ccaaagacga agaacctgag aaattgagac tcatcgattc aatccaacgc 240
ttaggcgttt gttatcattt cgaatatgag atcaacaaaa tacttgaaca actccatcat 300
attactatta cttcaaaaaa taatggtgat gatcatcctt acaatatgac cctccgtttc 360
agacttctaa gacaacaagg ctacaacata tcatcgaagt cattcgaaag gtttcgaggc 420
aaatgggaaa gttcgtacga taaaaatgta gaagaactct tgagtttata tgaagcatcg 480
caattgagga tgcgaggaga agaagcatta gacgaagcgt ttcgtttcgc taccgctcag 540
ttggaagcca ttgtccaaga cccaacaacc gatccaacgg tcgtagggga agtctgccaa 600
gctttgaagt ggccgatgta caagaaccta ccaaggcttc aagcaagtca ctacattggt 660
ttgtacagcg agaagccatg gaggaatgag agtttgccta actttgcaaa gatggatttc 720
agcaaactgc aaaagcttca tcagaaagaa attgcttaca tctcaaagtg gtgggatgat 780
tatggttttg ctgaaaagct atcatttgca aggaacagga ttgtggaggg atactttttt 840
gctcttggga tattctttga acctcaactt tcaactgcta gacttattat gaccaaaatt 900
attgctattg gatcagtgtt agatgacatt tatgatgttt atggcacttt cgaagaactc 960
aaactcttga cgcttgcact tgagagatgg gataagagtg agacaaaaaa acttccaaaa 1020
tatatgaaga tgtactacga ggctttgtta gatgtttttg aagaaattga acaagaaatg 1080
agccaaaagg aaacaacacc atattgcatc catcagatga aagaagcgac aaaggagctt 1140
gggagggtat ttttggtaga ggccaaatgg tgtaaggaag gatacacccc aacagtagaa 1200
gaatacttgg atattgcttt aatatctttt ggccacaaat tgcttatggt aacagctctc 1260
ttaggaatgg gttcaaccat tgccacacaa caaattgttc aatggatcac ctccatgcct 1320
aatattctca aagcctccgc tattatttgt aggctcatga acgacatcgt ttcacataag 1380
tttgaacaag agcgaggtca cgtggcttct gccattgaat gttacatgga acaaaattat 1440
atgtcagagc atgatgtcct aattatatta ggtaaacaaa tagatgagtt ttggaaggat 1500
atggttgaga attattgtgt tgttatcacc gaagaagagg ttccaagggg tgttcttatg 1560
agagttttga accttacaag attatttaat gtgatttaca aagatggaga tggatataca 1620
caatctcatg gttccacaaa aacccatatc aaatctttgc ttgttgactc tcttccactc 1680
tag                                                               1683

<210> 576
<211> 1903
<212> DNA
<213> Cucumis sativus

<220> 
<223> (E,E)-alpha-caryophyllene synthase

<400> 576
tctcacccat agttcaaact ctcaagccaa taacatacac atctttctat ttagcaagag 60
gattatccca actacctttt ctatctttct tttctacttt gaaaagtcat gtcttctcat 120
tttcctgctt ccattatgaa aaccaatgat atttatgata ctaagcgttc tcttgcaaat 180
tttcatccta ctatttggaa ggaacatttt ctttcattca catttgatga tgcattgaaa 240
gtagatggtg gcatgaaaga aagaattgaa aagttgaaag aagaaataag gatgatggtg 300
attgcttctg tgcaaaatcc attggtaaag ctaaatttgg ttgattcaat ccaacggctg 360
ggagtatctt atcattttga agatgagatt gatcaattct tagaacatat gtatgtgtct 420
tataataatt cccttttatt cagtagcaac gatagtcaag atgatgatct tcatatttct 480
gctcttctat ttcggcttct caggcaacat ggttatagga tttcatgtga tatatttttg 540
aagttcatgg acaacaatgg aaaatttaaa gagtcattgg ttgaggatga aagaggaata 600
ttgagcctat atgaagcatc gcatatgagg gggcatggag aagcattgct tgaggaagct 660
cttgaattta caaccacaca tcttaaagca tatattcatc tttactcaaa tattaatcca 720
aattttgcat ctgaagttag taatgcattg aaattgccta ttagaaaatg tgttccaaga 780
gtcaaggcaa gagagtattt tgaaatttac cagcaacaac cttctcacaa tgagactttg 840
cttacattct caaaactgga cttcaacatc ttacaaaaac ttcaccagaa ggagatagct 900
gaaatctgca ggtggtggaa ggatttgaac gtttcaacaa actttccgtt tgcgagggat 960
cgaattgtgg agtgttactt ttggatattg agtatatatt ttgaacctta tttcaagttt 1020
ggaaggaaaa tattgactaa agtgattgct atgacctcaa ttatggatga tatatatgat 1080
gcttatggaa cattcgaaga actccaactt ttcaccttag caatcaaaag atgggacatg 1140
agcatggtca atctacttcc gcagtacatg aaagttcatt atacaactct gcttgatctt 1200
tttgaagaga tggataaggg gatagtcaat gatggaatat cctatcgctc ttgctttgga 1260
aaagaagcta tgaaaagaca agctgaatcc tatttcaaag aagctgaatg gctaaacaaa 1320
aattataaac caaaatatgg agaatacatg gaagtggctt tagctagttc aggttatgaa 1380
ttactttcaa ctatttcatt tgtttgcatg ggtgacattg caacaaagga agtatttgaa 1440
tggctttttg actgtcccca aattcttaaa gcctcaacca ccatttctag actcatggat 1500
gatgttgtct cctacaagtt tgagaaagaa agagaacaca ttgtttctgc agttgaatgt 1560
tacatgagca atcatggacg ctcagaagat gaaacatgtg ctgagttact taagcaagta 1620
gaagatgcat ggaagactat aaatgaatgt tgccttcatc caatgaatgt tccaatgcca 1680
tttttaattt gtctattaaa tctcacaaga gttatggctc tcctttattc tcacgaagat 1740
ggatatacaa attctaaggg taggactaaa cttcttattc agtctctact tattgatcca 1800
ttgcatttgt aattggtgtc tgtcaccaaa ttctaacttt tgttatattt ttaattattt 1860
aaaaaagctg cttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                   1903

<210> 577
<211> 1895
<212> DNA
<213> Cucumis sativus

<220> 
<223> (E)-alpha-farnesene synthase

<400> 577
ctcacaaaaa gctaaagcta atttcgacag caaacatata tagatatata tatttttctt 60
aaaaaaaaaa ggagaatgag ttcaaacgta tcagcaattc caaactcttt tgaattgatt 120
cgaaggtccg ctcaatttca agcgagtgtt tggggagact actttctttc ctatcattct 180
ctccctccgg aaaaaggcaa caaggtcatg gagaaacaaa cggaagaatt gaaagaagaa 240
ataaaaatgg agttggtttc tacaacaaaa gatgaacctg agaaattgag actcatcgat 300
ttaatccaac gcttaggcgt ttgttatcat ttcgaaaatg aaatcaacaa catacttcaa 360
caactccatc atattactat tacttcagaa aagaatggtg atgataatcc ttacaatatg 420
actctttgtt tcagacttct aagacaacaa ggctacaacg tatcatcgga gccattcgat 480
aggtttcgag gaaaatggga aagttcatac gataacaatg tagaagaact cttgagttta 540
tatgaagcat cgcaattgag gatgcaagga gaagaagcat tagacgaagc gttttgtttt 600
gctaccgctc agttggaagc cattgtccaa gacccaacca ccgatccaat ggttgcagcg 660
gaaatccggc aagctctgaa gtggccgatg tacaagaatc taccaaggct taaagcaaga 720
caccacattg gtttgtacag cgagaagcca tggaggaatg agagtttgct taactttgca 780
aagatggatt tcaacaaact gcaaaacctt catcagacag agattgctta catctcaaag 840
tggtgggatg attatggttt tgctgaaaaa ctgtcatttg caaggaacag gattgtggag 900
ggatattttt ttgctcttgg gatattcttt gaacctcaac ttttaaccgc tagacttatt 960
atgaccaaag ttattgctat tggatcaatg ttagatgaca tttatgatgt ttatggcact 1020
tttgaagaac tcaaactctt gacccttgca cttgagagat gggacaagag tgaaacaaag 1080
caacttccaa attatatgaa gatgtactac gaggctttgt tagatgtttt tgaagaaatt 1140
gaacaagaaa tgagccaaaa ggaaacagaa acaacaccat attgcatcca tcacatgaaa 1200
gaagcgacaa aggagcttgg aagggtattt ttggtagagg ccacatggtg taaggaagga 1260
tacaccccaa aagtggaaga atacttggat attgctttaa tatcttttgg ccacaaattg 1320
cttatggtaa cagctctctt agggatgggt tcacacatgg ccacacaaca aatcgttcaa 1380
tggatcacct ccatgcctaa tattctcaaa gcctccgctg ttatttgtag gctcatgaac 1440
gacatcgttt cacataagtt tgaacaagag cgaggtcatg tggcctctgc cattgaatgt 1500
tacatggaac aaaatcattt atcagagtac gaagccctaa ttgcattacg taaacaaata 1560
gatgatttat ggaaggatat ggttgagaat tattgtgctg ttatcacaga agatgaggtt 1620
ccaaggggtg ttcttatgag agttttgaac cttacaaggt tatttaatgt gatttacaaa 1680
gatggagatg gatatacaca atctcatggc tccacaaaag cccatatcaa atctttgctt 1740
gttgattctg taccactcta aatcttttta attcaaaagc tctctcttac acaaaaatat 1800
tgttatgttt atgttttgat tattgtattt gtatgatttt atatatgtat ataataatgt 1860
tcttacgaaa aaaaaaaaaa aaaaaaaaaa aaaaa                            1895

<210> 578
<211> 2637
<212> DNA
<213> Cucurbita maxima

<220> 
<223> copalyl diphosphate synthase 2

<400> 578
atgtcctcct cctcctctct ctctctctct cgccattgcc tgtcttcttc tttttccttc 60
cgtctcccaa acctcttccc accacctgca cctggtggct gttcgctgag ggttaaagac 120
aaaggcgctg tgctggaatc aagcatccga tgcattatca aatgcaacgc catttccaag 180
cctcccactc aagactacag cgatgtgctt caaagtggag tgccacttct aaagtggcag 240
cagtttgtgg aggagggcat agaatcagaa actgctgccc aggtgtcggt ttgggaagag 300
atagaggagc gagtgaagtg gataaagtca atgctgagtt caatggacga cggtgacata 360
agcatctcag cttatgacac ggcttgggtg gctctaatac caaaagttac ggaggaggga 420
gtgaagagtc cgcagttccc ttcttccctt gagtggatag ccaacaatca actcccggat 480
gggtcatggg gcgacgccca gatattctca ccccacgatc gcatcattaa cacattggct 540
tctctggtcg ccttgaagtc ttggaatctt catccccaaa acacacggaa aggagtagcc 600
ttcttcaacc aaaacatttg gaagctggaa gaggagaatg cggagcacat gccgatcggg 660
ttcgagattg ctttcccttc cctactcgaa tttgccaaga aactaaagct gggaatccgg 720
agcgactccc cggcgttgca acagattaat gcccgcaggc gcctaaagct tgcgaggata 780
ccaaaggaca taatgcacaa actgccaacc acgctattgc acagcttgga aggcatgagt 840
ggtttggatt gggaaaagct tctaaaattg caatctcaag acggctcctt cttgagctcc 900
ccagcctcca ctgccttcgc tctcatgcac accaaccacc caaattgctt caaatatttg 960
gaagcatcgg tgcaccgctt taatggtgga gtacccaacg tgtaccctgt ggacctgttc 1020
gaacacattt gggctgtgga cagattgcaa cgacttggaa tttctcgatt ctttcaccca 1080
cacattgttg agtgtgtgaa taatgtgcgc acacactgga gtgaaaaagg aatatgctgg 1140
gccagaaatt cggagtttcg cgacattgat gacacggcca tgggattcag actgctcaga 1200
ctgtacggcc acgatgtttc ggcggaggtg tttaagcatt tcgagaaaga tggggagttc 1260
gtgtgcatag cgggccagtc aacgcaggcg gtcaccggaa tgttaaactt gtaccgagct 1320
tcggatcagg taatgtttcc gggggagaaa attctagagg acgccaaaca atttgcctcc 1380
aagttcctca ggcagaaaca ggccgccaat cagctcttag acaagtggat catcgccaag 1440
gacttgcctg gagaggttgg ttacgctctt gacgttccat ggtttgcaag cttgcctcgg 1500
gttgagaccc gtctctacat acagcactat ggtggcaaaa atgacgtctg gattggaaaa 1560
actctctaca ggatgttcaa ggtcaacaac gatacatact tggagcttgc aaaattggac 1620
tacaacaact gccaaagatt gcatcagatt gagtgggttg atattcaaaa atggtacaca 1680
gaaagcaagc tgcgagatta tggaatgagg agaagcagca ttttgttctc atattttggt 1740
gcagtgtgta gcattttcga accagaaagg gccaaggaga ggcttgcatg gaccaaaact 1800
gctgctttgg tccacaccat tgcatcccat tacaaggatg ccaatgccca ccaacgacga 1860
gcctttctcc aacaatttac caactttcat gctgctcagc catacgataa taatgcatgg 1920
agatcaggca atatgcagca gaagggagga gaaggactag ttgggatttt gctgcgaact 1980
ctaacaaata tctcgttgga tatactgttg tcgcacggcg tcgacatcac ccaccatttg 2040
caccaagctt ggcaaaaatg ggtgtttaag tggcaagagg atggagatgt gcacaaggaa 2100
gaggcagagt tattggtgca gacaataatt ctcaactcag gctgttcaac tttggaggat 2160
ctgttgtcca attctcagtt tcagaagctt tccaacctca caaacaaagt gtgccatcaa 2220
cttgctcact ttaaaaagca taaggtaaat aacggtaacc tctataagga gaaaacagac 2280
aacaaaatgc ccccagagat agaagaagac ataaggaaac ttgtgcagct ggtgatccaa 2340
aaatcttcag atggcaatga cattgactca ccgattaagc aaacatttct aacagtagca 2400
aaaagtgtgt actatgcagc ttatttcgat gcttggacta tcaactacca catagccaag 2460
gtcctatttg aaagagtgtt ctaatcctag ctacccacac acccatgttg tatttgtatt 2520
gtcaaatttt gtatattctt caccacatgg gacacaaaaa ctttggtctg tgtttcttct 2580
gtcaataaaa agacatcatc tttaaaaccc aaaaaaaaaa aaaaaaaaaa aaaaaaa    2637

<210> 579
<211> 2658
<212> DNA
<213> Cucurbita maxima

<220> 
<223> ent-kaurene synthase B

<400> 579
gaaagcggta gttttcggct cttggctgtt tttgtgtact gcctattctg ttctttatat 60
gcactgaatg tgaaaatgcc tcaccagagt ttgatgctgc ttccgcaatt tctttgcatg 120
tcctaaacat accagtcatg tatctttccc gacctaccgg cgttgcccgt tttgctgcct 180
cctcctcctc ctcctcctca gcttccctat tccctggagt ggatgtggac acaacaacta 240
aaactggagc tttgcacttt gaagaaacaa aagaaagaat taagaaattg ttcgacaagg 300
ttgaactttc agtttctgca tatgatactg catgggtggc aatggttcct tctccaaact 360
ctctcaacca acctcttttc cccgagtgta taaactgggt attagatagt caacatgctg 420
atggctcatg gggcctactc cacaacgatc agttgctgat gaaggccaat ctcttatcta 480
cattagcatg tgttcttact cttaagcggt ggaatattgg gcatgatcat atgagcaagg 540
cccttgattt tatcaagtct aatatagctt cagctactga tgagaaccaa cgttctccgg 600
tgggatttga cattattttc cctggcatga ttgagtatgc taaagacttg aatttgaatc 660
tacccttggc accgacgaac gtggatgcct tggttcgaaa gaaagagttg gagctgagaa 720
gctgcagaag caactctgaa ggtggaaaag cctatttagc gtatgtttca gaaggaattg 780
gaaagttaca ggactgggat atggtcatgc aatatcaaag gaagaatgga tcactgttta 840
attctccatc cactacggca gcggctttta tgcatagaaa tgatgatggc tgttttgatt 900
atcttcgctc actcttacaa aagtttgatg gctcagttcc cacaatatat cctcttgata 960
tatatgctcg attacacatg gttgatagcc ttcaaaaatt cggaattgct cggcatttca 1020
aagaggagat tagaagcgta ttagatgaaa cttacaggtg ttggatgcaa ggagaggaaa 1080
atatattctt agatgcttca acttgtgcaa tggcctttcg aatgttacgt gttgaaggat 1140
atgatgtttc ttcagaccag ttgactcaat tttcagaaga tatctttccc aattgccttg 1200
gaggatattt aaaagacttc ggtgcctcgc tggagttata taaggcctct cagattatca 1260
cgcaccccga tgaatctgtt ctggaaaata taaactcttg gactagtcgt ttcctgaagc 1320
atggattatc tagtgattca gtttggtctg atagaaccga tagtgttgtt aaacaagagg 1380
ctgttaatgc tcttgagttc ccctataatg caactctaga acgcctaata agtaagaggg 1440
caatggaaag ttacagtgga gacattgtga ggatttcaaa atcgccatat gcctgcttaa 1500
attttggcca tcaagatttt ctggaacttg ctgtagagga tttcaatacc ctgcaacgca 1560
ttcatcttaa agaactggaa gagcttcaaa gatgggtggt tgaaaacaaa ttggacgagt 1620
tgaaattttt cagactgcac ctagggtact gctattttgc tgcggcagcg acccttactg 1680
atcctgaact tcatgatgct cgcatagcat gggcacaaaa tggtgtgctc acgaccgtgg 1740
ttgatgattt ctatgatggt ggaggatctg aagaggaatt ggataacctt atagaattgg 1800
tggaaaagtg ggatcctgat ggggaagtgg gttactgttc caaggacgtt gagattgtat 1860
ttcttgcact gcacagcaca gtttgtgaaa taggaagaag agctttagta tggcaaggac 1920
gcagtgttat gaggaatgtt atcgatggtt ggttggctct gctgaaggtg atgagaaagg 1980
aagctgaatg gtcgacaaat aaggtagtgc catcaatggg tgaatatatg gaacaagccc 2040
atgtatcatt cgcgttggga cctataatcc ttccaatgct cttctttgtt ggacctaaac 2100
tctcagagga aatgattgga agctgtgaat accagaagtt atataagctg atgagcactg 2160
ctggtcgcct taagaatgat attcgatctt acgatagaga atgcaaagag ggaaagctga 2220
atattctgtc tctgtggatg attgatggcg gtggtaatgt caccaaagag gaggccattg 2280
aagcaattaa aggggatttt gagagggcga taagagagct gctggggtta gttttgcagg 2340
agaacactac aattccaaga gcttgtaagg atttgttctg gaaattgatg tccattgtga 2400
atctatttta catggaagat gatgggtaca cttcaaatag gttgatgaac actgtaaaag 2460
ccatgtttga acaacccatg gatctggatg cactattgaa caaatgaacg aacaacaaac 2520
gaaataagtt gtagtgggaa gcagacgcca cctattcact gtcttctcta ctgatcagat 2580
gtctattgct ttctcattga ggaaatggca aataaaacat tttatggaaa catttcattg 2640
ttaaattgag acagtctg                                               2658

<210> 580
<211> 1976
<212> DNA
<213> Elaeis oleifera

<220> 
<223> sesquiterpene synthase

<400> 580
atccaagatc ttcacttact agttctattc tatatgtcca gcaacacgat ggaagctcat 60
ggatctacaa accattcttc agtgccatgc ggtggtgatg gaaccattcg cttccttgca 120
aattttcacc ctaccatttg gggcgattac ttcattgaaa attatccatt accttcgaat 180
cttcagaagt cagaggcatg tattgaaaaa aggagggaag agttaaaagt ggaagtaatg 240
aacttgctta aaaatgctaa tgattactta caagagatgg aattaattga tatacttcaa 300
cgtctgggtg tggcatatca ctttgaaaag aaaatagatg agatactaag ccaaattttt 360
aaagagcata tggaggatga taatttgcat gctgttgccc ttcgctttcg actcttgaga 420
caacatggct acaatatgcc tacaaatatt tttatcaagt tcaaagaagt cgatggaagt 480
ttcaaggcta ccttaagaaa tgatgtgaag ggtctgttaa gtctatatga agctgcttat 540
cttggtatcc caaaagataa tctattagat gaagcactga attttgcaaa attacatctc 600
aagtccatgg aaagccatat gaaaacccct cttgcagtac gagtactaga tgcctttgag 660
atgcctttac atagaagaac gacgaggtta gaggcaaaga attatatctc catttaccaa 720
caagatgatg gacggattaa tgtggtacta gagcttgcaa agttggattt tcatatactg 780
caatcaattc atagagaaga agttaggagc atctctatgt ggtggaaagc actcggcctt 840
gcaaaaaaac taaccttttg cagggataga gtagtcgagg gttatttttg gattcttgga 900
gtatattttg agcctcaata ttctagagca cgaatttatc tgacaaaggt gcttgcttta 960
ctttcaatca tggatgatat ctatgatact tatggcatag cagaggaact ccaagcattt 1020
actgaagtca tccgaaggtg ggacatagag gcagtggatc agctagatga ggtctataaa 1080
ctctatttcc ttaatctata taacacattc aaggaatttg aggatgagct cgcaaaggaa 1140
ggaaactcct atagggtgga atatcttaaa gaatcagtca aagaattatc aagggcttat 1200
cttgaagaag ttaaatggag ggacgaaggt tacgtgccgc ctcttaaaga atatctgaat 1260
gtttcacaga tctccactgt ccatgttgca ttatcctgtg cttcttttgt tggcatggga 1320
gaagaagcaa caaaagaggc attcgattgg gttacaagct tcccaagaat cataaagtct 1380
agttgcttaa tcggccggct cttggatgat gttgcatcca atgagtttga acatgagagg 1440
aagcatgtct cgtcggcagt ccattgctac atcaaagagc atggcacttc agtgcaagag 1500
gcatatgaga agctacgggg aatgattgaa gacgaatgga aaattatgaa tcaagagtat 1560
ctatgtatga ctaccatgcc aatgtctttg atcaggccaa tcatcaacct cccacggatg 1620
gcagaaaccg tatacaagaa gtgtgattca tacacgcact ctttatctac gatgaaagat 1680
tatatcatgt cgttgctggt cgagcccatt tcgttctgag aaggctatat taaagatcat 1740
gtcagctttc ttataggttc gcctatctat ctactacatt gttgttttgg attttcctat 1800
tgttggtcat tcttgtgcga gggagactaa gtggtgtgct tccatatcta ttcttggtac 1860
cttatagtgt gtgtaatcct ctaaaacaca ttgtcattgt catatgagcg agttagttct 1920
tgataaagtt gtatgacttt attatttaat catcttgact atggcaacaa ctcaac     1976

<210> 581
<211> 3103
<212> DNA
<213> Giberella fujikuroi

<220> 
<223> (-)-copalyl diphosphate/(-)-ent-kaurene synthase

<400> 581
caactgcttt cttctctcat caacacaaat ttgaagtttg tcactgtagt ggatctggaa 60
tacttacaca agatgcctgg caaaatcgag aacggcaccc ccaaagacct caagacagga 120
aatgactttg tatcagcagc aaagtcgctg ctggaccgcg ccttcaagag ccatcatagc 180
tactatggtc tatgttccac cagctgtcag gtatatgaca ctgcttgggt ggccatgata 240
cccaagacga gagacaatgt caagcaatgg ctgtttcctg agtgcttcca ctatcttctg 300
aagactcagg ccgctgatgg tagttggggt agtctcccca cgacccagac tgctggtatt 360
ctagacactg cttcagctgt gcttgcactc ttatgtcacg cacaagagcc tctgcagata 420
ctggacgtct cgccagacga gatgggtctc aggatcgagc acggggtaac ttctttgaag 480
cgacagctag ctgtttggaa cgatgttgaa gataccaatc acattggtgt cgagtttatt 540
attccagctt tactttccat gcttgagaaa gagctcgacg tgccatcttt tgagtttcct 600
tgcagaagta tcttggagag gatgcacgga gagaagctcg gccatttcga tttggagcaa 660
gtatatggca agccgtcttc actacttcac tcccttgaag cctttcttgg aaagcttgac 720
tttgatcgcc tttctcacca tctttatcat ggctctatga tggcttcacc ttcttccact 780
gcagcctacc tcattggtgc aaccaagtgg gacgacgagg ctgaagatta cctgaggcac 840
gttatgagaa atggtgctgg tcacgggaat ggtggcatct caggcacctt tcctacaaca 900
cattttgagt gtagctggat catagcgaca ctcctgaagg ttggcttcac tttgaaacaa 960
atcgatggtg atggcttgcg cggcttgtca actatacttc tcgaagcgtt gagggacgag 1020
aatggagtaa ttggctttgc accccgtact gctgatgttg atgacactgc aaaagctctt 1080
ctggcattga gccttgtcaa tcaacctgtc agcccagata tcatgatcaa ggtctttgaa 1140
ggaaaagatc acttcaccac gttcggatct gaacgtgatc ccagcttgac ttccaacctc 1200
catgtgctgc tgagtctcct gaagcagtcc aatctatcgc aataccaccc acaaatcctg 1260
aagaccacgt tgttcacttg ccgatggtgg tggggcagcg accattgcgt caaagataaa 1320
tggaatttga gtcatctata cccaaccatg cttctggtgg aagctttcac cgaggtactt 1380
catctcattg atggtggcga gctttctagt ctctttgacg agagcttcaa gtgcaagatc 1440
ggcctgtcaa tcttccaggc tgtactacgt atcatcctca cccaagataa cgacggatct 1500
tggagaggat atcgcgagca aacatgctac gccattctag ctcttgtaca ggcacgccat 1560
gtatgtttct tcactcacat ggtggacagg ctacagagtt gcgtcgaccg tggcttttcg 1620
tggctcaagt cctgcagctt tcattctcag gacctcactt ggacgtcaaa gacagcatat 1680
gaggttgggt ttgttgctga agcgtacaag ctagcagccc ttcagtcagc aagcctagag 1740
gtgcccgccg ctactattgg ccacagcgtc acctcggcgg ttccatcatc ggacttggag 1800
aagtacatga ggcttgtgcg caagactgct ttgttctcgc cactggacga gtggggactc 1860
atggcgtcaa tcattgagtc ctcgttcttc gtgccccttc tacaagctca gcgcgttgag 1920
atttatccga gggacaacat caaggtcgac gaggacaaat acctgagcat cattcctttt 1980
acttgggtcg gatgcaacaa cagatcccgc acatttgcat ctaacagatg gctctacgat 2040
atgatgtacc tgtccctcct gggctaccag accgatgagt acatggaagc tgtcgctggg 2100
ccggtattcg gtgatgtctc tctgcttcac cagaccatcg acaaggtcat agacaacaca 2160
atgggaaact tagccagggc caatggtacc gtgcacagtg gcaatggtca tcagcatgag 2220
tcacccaaca ttggacaagt tgaggatact ctcactcgct tcaccaacag cgtgctcaac 2280
cacaaagatg ttctgaattc aagctcttct gaccaagaca ctcttcgccg agaattcaga 2340
acgttcatgc atgcccatat cacacagata gaggacaaca gtcgcttctc caagcaggcc 2400
tccagcgacg ctttctcttc cccagaacaa tcgtacttcc aatgggtcaa cagtacagga 2460
ggcagtcacg tcgcctgcgc gtactcattc gctttctcca actgcctaat gtcagcgaat 2520
ctgctccaag gcaaggacgc atttccctcc ggcactcaga aatatctcat ttcatccgtt 2580
atgcgtcacg ctacaaatat gtgtcgtatg tacaacgact ttgggtccat agctcgcgat 2640
aacgctgagc ggaatgtgaa ctcgatccac ttccccgagt tcacgttatg taacggaacg 2700
tcacagaatc tcgatgaaag gaaagagaga cttttaaaga tagctacgta tgagcaaggt 2760
tatcttgatc gtgctctcga agctctggaa cgacagtctc gtgatgatgc aggtgatcgt 2820
gctgggtcta aggatatgag gaagctcaag attgtaaaac tgttctgtga tgtcaccgac 2880
ttgtatgatc agctttacgt gatcaaggac ctttcaagca gcatgaagtg agggaatact 2940
atggagctgg taattttgat atgtattttc ctctagttta tttgaagaca catagtttca 3000
gtaagtgctc acaagactgc aaacccatca aagcttggtc cgtctgatat ggagcatcgg 3060
atacatggtt tgcactcccg caaagaaatt caacactcgg cct                   3103

<210> 582
<211> 2705
<212> DNA
<213> Ginkgo biloba

<220> 
<223> levopimaradiene synthase

<400> 582
atatttgcct aaacctgcac aaatggctgg ggtgctcttt gcaaatctgc cttgctcact 60
gcaactctct ccaaaagttc ccttccggca atccactaat attcttattc cttttcacaa 120
gagatcctca tttggattta atgcacagca ctgcgtccgt tctcacttaa ggctgagatg 180
gaattgtgtc gggattcatg cctcagctgc agagactcgt ccagatcagc ttccacagga 240
ggaacgcttt gtgtcgagac ttaatgcgga ttatcatcca gctgtctgga aggacgattt 300
catcgactct ctaacatccc ctaattccca cgcgacatcg aaatcaagcg tcgatgagac 360
aatcaataaa agaatccaga cattggtgaa ggaaatccag tgcatgtttc agtccatggg 420
cgacggtgaa acgaatccat ctgcatatga tacagcttgg gtggcaagaa ttccgtcaat 480
tgacggctct ggtgcacccc aatttcccca aacgcttcaa tggattctga acaatcaact 540
gccagatggc tcgtggggtg aggagtgcat ttttctggcg tatgacagag ttttaaacac 600
tctcgcctgc ctcctcactc tcaaaatatg gaataagggc gacattcaag tgcagaaagg 660
ggttgagttt gtgagaaaac acatggaaga aatgaaggac gaagctgaca atcacaggcc 720
aagtggattc gaggtcgtgt ttcctgcaat gttagatgaa gcaaaaagct tgggattgga 780
tcttccttat cacctccctt tcatctccca aatccaccaa aagcgccaga aaaagcttca 840
aaagattccc ctcaatgttc ttcataacca tcagacggcg ttgctctact ctctggaggg 900
tttgcaagat gtggtggact ggcaagagat cacaaatctt caatcaagag acggatcatt 960
tttaagctcc cctgcatcta ctgcttgtgt cttcatgcac actcaaaaca aacgatgcct 1020
ccactttctc aacttcgtgc tcagcaaatt tggcgactac gttccttgcc attacccact 1080
tgatctattt gaacgcctct gggctgtcga tacagttgaa cgcttgggaa tcgatcgcta 1140
tttcaagaaa gaaatcaaag aatctctgga ttacgtttat aggtactggg acgccgaaag 1200
aggcgtggga tgggcaagat gcaatcctat tcctgatgtc gatgacactg ccatgggtct 1260
tagaatcctg agacttcatg gatacaatgt atcttcagat gttctggaga atttcagaga 1320
cgagaaagga gacttctttt gctttgccgg tcaaacgcaa attggtgtga ccgataatct 1380
taacctttat agatgttcac aagtatgttt tccgggagaa aagataatgg aagaagctaa 1440
gaccttcact acaaatcatc tccaaaatgc tcttgccaaa aacaacgcat ttgataagtg 1500
ggctgtcaag aaggatcttc ctggagaggt ggagtatgct ataaagtatc cgtggcatag 1560
aagtatgcca agattggagg caagaagtta catagagcaa tttggatcaa atgatgtctg 1620
gctggggaag actgtgtata agatgctata tgtgagcaac gaaaaatatt tggagctggc 1680
caaattggac ttcaatatgg tgcaggcctt acaccaaaag gagactcaac acattgtcag 1740
ctggtggaga gaatcgggat tcaatgatct tacattcacc cgccagcggc ctgtggaaat 1800
gtatttctca gtggcggtta gtatgtttga gccagaattc gctgcttgta gaattgccta 1860
tgccaagact tcttgcctcg cagttattct agacgatctt tacgacaccc acggatctct 1920
ggatgatctt aaattgttct ctgaagcggt ccgaagatgg gatatctctg tgctggatag 1980
cgttcgggat aatcagttga aagtttgctt cctagggctg tacaacacag tgaatggatt 2040
tggaaaagat ggactcaagg aacaaggccg tgatgtgctg ggctatcttc gaaaagtatg 2100
ggagggcttg ctcgcatcgt ataccaaaga agccgaatgg tcggcagcaa agtatgtgcc 2160
gacattcaac gaatatgtgg aaaatgccaa agtgtccata gcacttgcga cagtcgtact 2220
aaactcaatc tttttcactg gagaattact tcctgattac attttacagc aagtagacct 2280
tcggtccaaa tttctgcatc ttgtgtcttt gactggacga ctaatcaatg acaccaagac 2340
ttaccaggcc gagagaaacc gtggtgaatt ggtttccagc gtacagtgct acatgaggga 2400
aaatccggag tgcacagagg aagaagctct aagtcatgtt tatggtatca tcgacaacgc 2460
actgaaggaa ttgaattggg agttggccaa cccagcgagc aatgccccat tgtgtgtgag 2520
aagactgctg ttcaacactg caagagtgat gcagctgttt tatatgtaca gagatggctt 2580
tggtatctct gacaaagaga tgaaagacca tgtcagccga actcttttcg atcctgtggc 2640
gtagcatact gatattatat ataatattca tattcaatcc aaaaaaaaaa aaaaaaaaaa 2700
aaaaa                                                             2705

<210> 583
<211> 3950
<212> DNA
<213> Gossypium arboreum

<220> 
<223> (+)-delta-cadinene synthase

<400> 583
aatttaactt ttattaattt aaaatttaaa gatttcaaag gggttctaaa atggaaattt 60
ttcgatttta agggaattgt gccagcccct agtttcgccc ttgtttgtag tgctttattt 120
taaaaaagta aatataatag aatatgtata tatatatata tataaaccaa agtgaaagat 180
gaaaatttat ataaatgatc gctgcaagct tcaagctcac aataatatga ttctttacca 240
tcaagaaaca ttggtgcttt atacagagaa aagaaaaact ttggtcctcc tcgtagctaa 300
tattttaaca atttaatttt tatataataa atttttaaca attatttcat attttttaaa 360
tatattcatg ttgaatgtag cagtatatag ttatattagt tatgctcata aattttggat 420
gcattagatt ttccttatgt aatttgataa caatgattat tatttttact tctaacaaat 480
aattaaatat ttttttgttg attcgataaa tatcattatt ttttaaatga tttaaaatat 540
aaaaataata atagattcga ccgaacgctc accctattga gtgagtatat caattattag 600
aatttaatta aaaaaggaaa ccaaatatag ccggcttaat tttgtttaat attaatttat 660
gtgtggaaat tcacttaaaa acagagtcca tggctgctaa catattatat attaaaccat 720
ttcctattaa taaatttatg aacgagagtt acatccttct aaattcattt tacttagagg 780
cggagtataa tattttatgt agtagttatt cttttactat ataaataaat aaataaaatt 840
ttaatcgcct gtgtattatg attgattcag ctgaatcaaa gttggaataa tattttaatt 900
tgggatccca attaattgag attggtttga ttttgggttg taaatatttt ttattaattt 960
tagataaatt attggaagtt ggagtcaaaa ttgaccgtct cagctaatta tacaaataat 1020
aataatatag agaaatgggt atattgctca acactcacat ttactacgtc agcaatagtc 1080
agacagactg ctaagtaaac aatgtacact caattcgagt caaacaaatc ctttatccca 1140
agattctaaa ataatgtgtt tgaggcacca attttgaagg atagaaagtg gaaacaaaca 1200
aaaggatatt aaaaaacaag gaaatttctc actgtatttg catatttttc tccttccagt 1260
ataattaaaa tacgtgcaat ttacgttgta ctttgttgac tcctatctta tacctataaa 1320
tacatgcaac aattgcacac atcgtctcat ccaaaacctg tgttttaaac actaaacagt 1380
aagcaaaggc agcaaattaa tctttgaatt atttgcttcc aaaaccctac acttttcctt 1440
caacacatcc tagaaaatgg cttcacaagc ttctcaagtt cttgcttcac cccatcccgc 1500
catttcatcc gaaaatcgac ccaaggctga ttttcatccc ggtatttggg gtgatatgtt 1560
catcatctgt cctgatacgg taatctataa tttttttctt actttctctt ttatcgattt 1620
ttaagttttt tggagatttc atggaaaagc attatacgta cttgagcagg atatcgatgc 1680
tgcaactgaa ttacaatatg aagaattaaa agcacaagtg aggaagatga ttatggaacc 1740
tgttgatgat tcaaaccaaa agttgccctt cattgatgct gttcaaagat taggtgtgag 1800
ttatcatttt gagaaagaga ttgaagatga actagagaat atttaccgtg acaccaacaa 1860
caatgatgcg gacaccgatc tctacactac agctcttcga ttccggttac ttagagagca 1920
tggcttcgat atttcttgtg gtaattaagt cttaaacttt cataactctt cttatccatt 1980
tatcaattaa tattatcaaa ctttacatta ataatcatct gtacaatact tcaatatata 2040
tatatttatt gatgaaacta atgtttgatg atgattttgg gtgcttgacc agatgcattc 2100
aacaagttca aagatgaggc agggaacttc aaggcatcat tgacaagtga tgtgcaaggg 2160
ttgttggaac tttatgaagc ttcctatatg agggtccatg gggaagatat acttgatgaa 2220
gccatttctt tcaccactgc tcaacttaca cttgctctac caactttaca ccatccttta 2280
tcggaacagg tcggccatgc cttaaagcag tctatccgaa ggggcttgcc aagggttgag 2340
gcccggaatt tcatttcgat ataccaagat ttagaatccc ataacaaatc gttgcttcaa 2400
tttgcaaaga ttgatttcaa cttgttgcag cttttgcata ggaaagagct aagtgagatc 2460
tgcaggtaag tgtttggaga tctttaaagc tatgaagtct aatactattt caattgatca 2520
cacgactgtt gctgacattt tatgatgctt tttttaggtg gtggaaagat ttagacttta 2580
caagaaaact accatttgca agagatagag tggttgaagg ctatttttgg ataatgggag 2640
tttactttga accccaatac tctcttggta gaaagatgtt gacaaaagtc atagcaatgg 2700
cttccattgt tgatgatact tatgattcat atgcaaccta tgatgaactc attccctata 2760
caaatgcaat tgaaggtgag attttttttc ctttcctcca aaaaaaaaaa aagtttttga 2820
gatcccccaa gaatagggga aaatatatgt ttttaaacgt taggatattc actccaactt 2880
gcagttgctc atattttaat ggtgatagta tgaactaacc aggctaagtt ttagattcaa 2940
attaaccctg aaattgtgtt ttaggtggga tattaaatgc atgaaccaac tcccgaatta 3000
catgaaaata agctacaagg cactattaga tgtttatgaa gaaatggaac agctgttggc 3060
aaatcaaggg agacagtacc gagttgagta tgcgaaaaag gcggtatgta atgatacaat 3120
agtatgatat gctttaatca taaacgtata aaatttgaaa attacattag caatttgctt 3180
acttttttat gcctttaatc ctcagatgat acgtcttgtt caagcttacc ttttggaggc 3240
caaatggact catcaaaatt ataaaccaac ctttgaggaa tttagagata atgcattgcc 3300
aacctctggc tatgccatgc ttgctataac ggcgtttgtc ggcatgggcg aagttataac 3360
ccctgagacc ttcaaatggg ccgccagtga ccccaagatc attaaggctt ccaccattat 3420
ttgcaggttc atggacgata ttgctgaaca taaggtatac tatatattca tattcaagaa 3480
ttctaaaaat cgattatggt atatatatgc acttaaatct atatcataga attgtaaggc 3540
ttctagggtt tgcatttgct aagttaatta atatacatgg ttcatatggg tgcagttcaa 3600
ccataggaga gaagacgatt gctcagcgat cgaatgttac atgaaacaat atggggtgac 3660
agcgcaggaa gcatacaatg aattcaacaa acacattgag agttcatgga aagatgtaaa 3720
tgaagagttc ttgaaaccga cagaaatgcc gacacccgtt ctttgtcgta gcctcaacct 3780
tgctagggtt atggatgtac tttacagaga aggtgacggt tatacacatg ttgggaaagc 3840
tgctaaaggt gggatcactt cattattgat tgatccaata caaatttgaa attcaacatt 3900
ggcttaagat ttactatgag ataaaattaa taaggtttgt acaatgaagg            3950

<210> 584
<211> 1883
<212> DNA
<213> Gossypium arboreum

<220> 
<223> (+)-delta-cadinene synthase

<400> 584
ctaaacagta agcaaaggca gcaaattaat ctttgaatta tttgcttcca aaaccctaca 60
cttttccttc aacacatcct agaaaatggc ttcacaagct tctcaagttc ttgcttcacc 120
ccatcccgcc atttcatccg aaaatcgacc caaggctgat tttcatcccg gtatttgggg 180
tgatatgttc atcatctgtc ctgatacgga tatcgatgct gcaactgaat tacaatatga 240
agaattaaaa gcacaagtga ggaagatgat tatggaacct gttgatgatt caaaccaaaa 300
gttgcccttc attgatgctg ttcaaagatt aggtgtgagt tatcattttg agaaagagat 360
tgaagatgaa ctagagaata tttaccgtga caccaacaac aatgatgcgg acaccgatct 420
ctacactaca gctcttcgat tccggttact tagagagcat ggcttcgata tttcttgtga 480
tgcattcaac aagttcaaag atgaggcagg gaacttcaag gcatcattga caagtgatgt 540
gcaagggttg ttggaacttt atgaagcttc ctatatgagg gtccatgggg aagatatact 600
cgatgaagcc atttctttca ccactgctca acttacactt gctctaccaa ctttacacca 660
tcctttatcg gaacaggtcg gccatgcctt aaagcagtct atccgaaggg gcttgccaag 720
ggttgaggcc cggaatttca tttcgatata ccaagattta gaatcccata acaaatcgtt 780
gcttcaattt gcaaagattg atttcaactt gttgcagctt ttgcatagga aagagctaag 840
tgagatctgc aggtggtgga aagatttaga ctttacaaga aaactaccat ttgcaagaga 900
tagagtggtt gaaggctatt tttggataat gggagtttac tttgaacccc aatactctct 960
tggtagaaag atgttgacaa aagtcatagc aatggcttcc attgttgatg atacttatga 1020
ttcatatgca acctatgatg aactcattcc ctatacaaat gcaattgaaa ggtgggatat 1080
taaatgcatg aaccaactcc cgaattacat gaaaataagc tacaaggcac tattaaatgt 1140
ttatgaagaa atggaacagc tgttggcaaa tcaagggaga cagtaccgag ttgagtatgc 1200
gaaaaaggcg atgatacgtc ttgttcaagc ttaccttttg gaggccaaat ggactcatca 1260
aaattataaa ccaacctttg aggaatttag agataatgca ttgccaacct ctggctatgc 1320
catgcttgct ataacggcgt ttgtcggcat gggcgaagtt ataacccctg agaccttcaa 1380
atgggccgcc agtgacccca agatcattaa ggcttccacc attatttgca ggttcatgga 1440
cgatattgct gaacataagt tcaaccatag gagagaagac gattgctcag caatcgaatg 1500
ttacatgaaa caatatgggg tgacagcgca ggaagcatac aatgaattca acaaacacat 1560
tgagagttca tggaaagatg taaatgaaga gttcttgaaa ccgacagaaa tgccgacacc 1620
cgttctttgt cgtagcctca accttgctag ggttatggat gtactttaca gagaaggtga 1680
tggttataca catgttggga aagctgctaa aggtgggatc acttcattat tgattgatcc 1740
aatacaaatt tgaaattcaa cattggctta agatttacta tgagataaaa ttaataaggt 1800
ttgtacaatg aaggaaatgt ataatttcat tacattattt gatttgtttc ttctatacaa 1860
aagaatgaac aagcggataa tct                                         1883

<210> 585
<211> 1890
<212> DNA
<213> Gossypium arboreum

<220> 
<223> (+)-delta-cadinene synthase isozyme C2

<400> 585
gagcaaacca agaaaaggct gcaaattcag cttctcaata tctgcttttg atcaatcgaa 60
atggcttcac aagtttctca aatgccttct tcatcacccc tttcttccaa taaggatgaa 120
atccgtccca aagccgattt tcagcctagc atttggggag atttcttcct caattgtccc 180
gacaagaata ttgatgctgg aactgaaaaa cgccaccaac aattgaaaga agaagtgagg 240
aagatgattg tggcaccaat ggctaattcg acccaaaagt tagccttcat tgattcagtc 300
caaagactgg gtgtgagtta ccatttcacc aaggagatcg aagatgaact agagaatatc 360
taccataaca acaatgatgc cgagaacgac ctctacacta catctcttcg attccgacta 420
ctccgagagc atggatacaa tgtttcatgc gacgtattca acaagtttaa agacgagcaa 480
gggaatttca agtcatccgt gacaagcgat gttcaaggat tgttggaact ttaccaagct 540
tcctatttga gggttcatgg ggaagatata ttggatgaag caatttcttt caccaccaac 600
catttaagcc ttgcagtatc atctttggac catcctttgt ccgaagaggt ttctcatgct 660
ttgaaacaat caattcgaag aggcttgcca agggttgagg caaggcacta tctttcagta 720
taccaagata ttgagtccca caataaggct ttgttggagt ttgctaagat cgacttcaac 780
atgttacaat ttttgcatag gaaagagcta agcgagattt gtaggtggtg gaaagattta 840
gactttcaaa gaaagttgcc atatgcaaga gatagagtgg ttgaaggcta tttttggatc 900
tcaggagtgt actttgagcc ccaatattca cttggtagaa agatgttgac aaaagtgata 960
gcaatggcat ctattgtaga tgatacatat gactcatatg caacatatga agagctcatt 1020
ccatatacaa atgcaattga gaggtgggat atcaaatgca tagatgaact tcctgaatac 1080
atgaagccga gctacaaggc actattagat gtttataaag aaatggaaca actggtggct 1140
gagcatggga gacaatatcg tgtcgaatat gcgaaaaatg cgatgatacg acttgctcaa 1200
tcttatcttg tggaggccag atggactctt caaaactaca aaccatcatt cgaagagttt 1260
aaggctaatg cattgccaac ttgtggttat gccatgcttg ctattacatc tttcgtcggc 1320
atgggagata tcgtaacacc agagaccttt aaatgggcag ccaatgaccc taagatcatt 1380
caagcttcca caattatttg taggtttatg gatgatgttg cggaacacaa gtttaagcat 1440
aggagagaag atgattgctc agcaatagag tgttacatgg aagaatatgg cgtatcagca 1500
caagaggcat acgatgtatt caacaagcat gttgagagtg cctggaagga tgtgaatcaa 1560
gagtttcaga aaccaacaga aatgccaaca gaagttttaa atcgtagcct aaaccttgca 1620
agggtgatgg atgtacttta cagggaagga gatggatata catatgttgg aaaagcggct 1680
aagggtggaa tcacttcatt gcttattgaa ccaattgcac tttgaaattt atattaaatt 1740
ttcctcttca agcatcttcc ttaagaaata gttattaagt tctaattaat aatgttgtat 1800
aatattcata tatattatca aagaaagtcc gaatcgattg tctttgtact cattaccttc 1860
tattaattca ataaagttct tttcaagctt                                  1890

<210> 586
<211> 1892
<212> DNA
<213> Gossypium arboreum

<220> 
<223> (+)-delta-cadinene synthase isozyme XC1

<400> 586
ccaaatttca agagcaaacc aaaaaaaggc tgcaaattca gcttttcaat atttgctttt 60
gatcaatcga aatggcttca caagtttctc aaatgccttc ttcatcaccc ctttcttcca 120
ataaggatga aatgcgtccc aaagccgatt ttcagcctag catttgggga gatctcttcc 180
tcaattgtcc cgacaagaat attgatgctg aaactgaaaa gcgccaccaa caattgaaag 240
aagaagtgag gaagatgatt gtggcaccaa tggctaattc aacccaaaag ttagccttca 300
ttgattcagt ccaaagactg ggtgtgagtt accatttcac caaggagatc gaagatgaac 360
tagagaatat ctaccataac aacaatgatg ccgagaacga cctctacacc acatccattc 420
gattccgact actccgagag catggataca atgtttcatg cgacgtattc aacaagttta 480
aagatgagca agggaatttc aagtcatccg tgacaagcga tgttcgagga ttgttggaac 540
tttaccaagc ttcttatttg agggttcatg gggaagatat attggatgaa gcaatttctt 600
tcaccaccca ccatttaagc cttgcagtag catctttgga ccatcctttg tccgaagagg 660
tttctcatgc tttgaaacaa tcaattcgaa gaggcttgcc cagggttgag gcaaggcact 720
atctttcagt ataccaagat attgagtccc ataataaggc tttgttggag tttgctaaga 780
tcgatttcaa catgttacaa tttttgcata ggaaagagct aagtgagatt tgtaggtggt 840
ggaaggattt agactttcaa agaaagttgc catatgcaag agatagagtt gttgaaggtt 900
acttttggat ctctggagtg tactttgagc cccaatattc acttggtaga aagatgttga 960
caaaagtgat agcaatggca tccattgtag atgatacata tgactcatat gcaacatatg 1020
aagagctcat tccctataca aatgcaattg agaggtggga tatcaaatgt atagatgaaa 1080
ttcccgaata catgaaacca agctacaagg ctctattaga tgtttatgaa gaaatggtac 1140
aattggtggc tgagcatggg agacaatatc gtgtcgagta tgcgaagaat gcgatgatac 1200
gacttgctca atcttatctt gtggaggcca aatggactct tcaaaactat aaaccatcat 1260
tcgaggagtt taaggctaat gcattgccaa cttgtggtta tgccatgctt gctattacat 1320
ctttcgtcgg catgggagat atcgtaacac cagagacctt taaatgggca gctagtgacc 1380
ctaagatcat tcaagcgtcc acaattattt gtaggtttat ggatgatgtt gctgaacaca 1440
agttcaagca taggagagaa gacgattgct cagcaatcga gtgttacatg gaagaatatg 1500
gcgtaacagc acaagaggca tatgatgtat tcaacaagca tgttgagagt gcttggaagg 1560
atttaaatca agagtttttg aaaccaacag aaatgccaac agaggttttg aatcgtagcc 1620
taaaccttgc aagggtgatg gatgtgcttt acagggaagg cgatggctat acatatgttg 1680
gaaaagcggc aaagggtgga atcacttcat tgctcattga accaattgca ctttgaaatt 1740
atgttaattt ttcctctcca agcttgtttc ttaagaaata gttattaagt tctaattaat 1800
aatgttttat aatattcata tattataaaa gaaagtccaa atcgattgtc tttgtactta 1860
ttgccttata ttaattcaat aaggttcttt cc                               1892

<210> 587
<211> 1893
<212> DNA
<213> Gossypium arboreum

<220> 
<223> (+)-delta-cadinene synthase isozyme XC14

<400> 587
ccaaatttca agagcaaacc aaaaaaaggc agcaaattaa gcttttcaat atttgctttt 60
gatcaatcga aatggcttca caagtttctc aaatgccttc ttcatcaccc ctttcttcca 120
ataaggatga aatgcgtccc aaagccgatt ttcagcctag catttgggga gatctcttcc 180
tcaactgtcc cgacaagaat attgatgctg aaactgaaaa gcgccaccaa caattgaaag 240
aagaagtaag gaagatgatt gtggcaccaa tggctaattc aacccaaaag ttagccttca 300
ttgattcagt ccaaaggctg ggtgtgagtt accatttcac taaggagatc gaagatgaac 360
tagagaatat ctaccataac aacaatgatg ccgagaacga cctctacacc acatcccttc 420
gattccgatt actccgagag catggattca atgtttcatg cgacgtattc aacaagttta 480
aagacgagca agggaatttc aagtcatccg tgacaagcga tgttcgagga ttgttggaac 540
tttaccaagc ttcctatttg agggttcatg gggaagatat attggatgaa gcaatttctt 600
tcaccaccaa ccatttaagc cttgcagtag catctttgga ctatccgtta tccgaagagg 660
tttcacatgc tttgaaacaa tcaattcgaa gaggcttgcc aagggttgag gcaagacact 720
atctttcagt ataccaagat attgagtccc ataataaggt tttgttggag tttgctaaga 780
tcgatttcaa catggtacaa cttttgcata ggaaagagct aagtgagatt tctaggtggt 840
ggaaggattt agactttcaa agaaagttgc catacgcaag agatagagtt gttgaaggct 900
atttttggat ctcaggagtg tactttgagc cccaatattc tcttggtaga aagatgttga 960
caaaagtgat agcaatggct tctattgtag atgatacata tgactcatat gcaacatatg 1020
aagagctcat tccctataca aaagcaattg agaggtggga tatcaaatgc atagatgaac 1080
ttcctgaata catgaaacca agctacaaag cgctattaga tgtttatgaa gaaatggaac 1140
aattggtggc taagcatggg agacaatatc gtgtcgaata tgcgaaaaat gcgatgatac 1200
gacttgctca atcttatctt gtggaggcca gatggactct tcaaaactac aaaccatcat 1260
ttgaggagtt taaggctaat gcattgccaa cttgtggtta tgccatgctt gctattacat 1320
ctttcgtcgg catgggagat attgtaacac cagaaacctt taaatgggca gccaatgacc 1380
ctaagatcat tcaagcttcc acaattattt gtaggtttat ggatgatgtt gctgaacaca 1440
agttcaaaca taggagagaa gacgattgct cagcaattga gtgttacatg gaagaatatg 1500
gcgtaacagc acaagaggca tatgatgtat tcaacaagca tgttgaaagt gcttggaagg 1560
atgtgaataa agagttcctg aaaccaacag aaatgccaac agaagttttg aatcgtagcc 1620
taaaccttgc aagggtgatg gatgtacttt acagagaagg tgatggctac acatatgttg 1680
gaaaagctgc taagggtgga atcacttcat tactcattga accagttgca ctttgaaatc 1740
atgttaaatt ttcctcttct gttccttaag gaatagttat taagttataa ttaataatgt 1800
tttataatat tcatatatta taaaagaaag ttcaaatcaa ctgtctttgt attcatttcc 1860
ttgtattgat ccaataaagt tcttttcaag ctt                              1893

<210> 588
<211> 1892
<212> DNA
<213> Gossypium arboreum

<220> 
<223> (+)-delta-cadinene synthase

<400> 588
ccaaatttca agagcaaacc aaaaaaaggc tgcaaattca gcttttcaat atttgctttt 60
gatcaatcga aatggcttca caagtttctc aaatgccttc ttcatcaccc ctttcttcca 120
ataaggatga aatgcgtccc aaagccgatt ttcagcctag catttgggga gatctcttcc 180
tcaattgtcc cgacaagaat attgatgctg aaactgaaaa gcgccaccaa caattgaaag 240
aagaagtgag gaagatgatt gtggcaccaa tggctaattc aacccaaaag ttagccttca 300
ttgattcagt ccaaagactg ggtgtgagtt accatttcac caaggagatc gaagatgaac 360
tagagaatat ctaccataac aacaatgatg ccgagaacga cctctacacc acatccattc 420
gattccgact actccgagag catggataca atgtttcatg cgacgtattc aacaagttta 480
aagatgagca agggaatttc aagtcatccg tgacaagcga tgttcgagga ttgttggaac 540
tttaccaagc ttcttatttg agggttcatg gggaagatat attggatgaa gcaatttctt 600
tcaccaccca ccatttaagc cttgcagtag catctttgga ccatcctttg tccgaagagg 660
tttctcatgc tttgaaacaa tcaattcgaa gaggcttgcc cagggttgag gcaaggcact 720
atctttcagt ataccaagat attgagtccc ataataaggc tttgttggag tttgctaaga 780
tcgatttcaa catgttacaa tttttgcata ggaaagagct aagtgagatt tgtaggtggt 840
ggaaggattt agactttcaa agaaagttgc catatgcaag agatagagtt gttgaaggtt 900
acttttggat ctctggagtg tactttgagc cccaatattc acttggtaga aagatgttga 960
caaaagtgat agcaatggca tccattgtag atgatacata tgactcatat gcaacatatg 1020
aagagctcat tccctataca aatgcaattg agaggtggga tatcaaatgt atagatgaaa 1080
ttcccgaata catgaaacca agctacaagg ctctattaga tgtttatgaa gaaatggtac 1140
aattggtggc tgagcatggg agacaatatc gtgtcgagta tgcgaagaat gcgatgatac 1200
gacttgctca atcttatctt gtggaggcca aatggactct tcaaaactat aaaccatcat 1260
tcgaggagtt taaggctaat gcattgccaa cttgtggtta tgccatgctt gctattacat 1320
ctttcgtcgg catgggagat atcgtaacac cagagacctt taaatgggca gctagtgacc 1380
ctaagatcat tcaagcgtcc acaattattt gtaggtttat ggatgatgtt gctgaacaca 1440
agttcaagca taggagagaa gacgattgct cagcaatcga gtgttacatg gaagaatatg 1500
gcgtaacagc acaagaggca tatgatgtat tcaacaagca tgttgagagt gcttggaagg 1560
atttaaatca agagtttttg aaaccaacag aaatgccaac agaggttttg aatcgtagcc 1620
taaaccttgc aagggtgatg gatgtgcttt acagggaagg cgatggctat acatatgttg 1680
gaaaagcggc aaagggtgga atcacttcat tgctcattga accaattgca ctttgaaatt 1740
atgttaattt ttcctctcca agcttgtttc ttaagaaata gttattaagt tctaattaat 1800
aatgttttat aatattcata tattataaaa gaaagtccaa atcgattgtc tttgtactta 1860
ttgccttata ttaattcaat aaggttcttt cc                               1892

<210> 589
<211> 1851
<212> DNA
<213> Gossypium hirsutum

<220> 
<223> (+)-delta-cadinene synthase

<400> 589
ttttcaatat ttgcttttaa tcaatcgaaa tggcttcaca agtttctcaa atgccttctt 60
catcacccct ttcttccaat aaggatgaaa tgcgtcccaa agccgatttt cagcctagca 120
tttggggaga tttcttcctc aattgtcccg acaagaatat tgatgctgaa actcaaaaac 180
gccaccaaca attgaaagaa gaagtgagga agatgattgt ggcaccaatg gctaattcaa 240
ccctaaagtt agccttcatt gattcagtcc agggactggg tgtgagttac catttcacca 300
aggagatcga agatgaacta gagaatatct accataacaa caatgatgcc gagaacgacc 360
tctacaccac atcccttcga ttccgactac tccgagagca tggattccat gtttcatgcg 420
acgtattcaa caagtttaaa gacgagcaag ggaatttcaa gtcatccgtg acaagcgatg 480
ttcgaggatt gttggaactt taccaagctt cctatttgag ggttcatggg gaagatatat 540
tggatgaagc aatttctttc accagcaacc atttaagcct tgcagtagca tctttggacc 600
atcctttatc cgaagaggtt tctcatgctt tgaaacaatc aattcgaaga ggcttgccaa 660
gggttgaggc aagacactat ctttcagtat accaagacat tgagtcccat aataaggttt 720
tgttggagtt tgctaagatc gatttcaaca tggtacaact tttgcataga aaagagctaa 780
gtgagatttc taggtggtgg aaggatttag actttcaaag aaagttgcca tacgcaagag 840
atagagtggt tgaaggctat ttttggatct caggagtgta ctttgagccc caatattctc 900
ttggtagaaa gatgttgaca aaagtgatag caatggcatc tattgtagat gatacatatg 960
actcatatgc aacatatgaa gagctcattc cctatacaaa tgcaattgag aggtgggata 1020
tcaaatgcat agatgaactt cctgaataca tgaaaccgag ctacaaggca ctattagatg 1080
tttatgaaga aatggaacaa ctggtggctg agcatgggag acaatatcgt gtcgaatatg 1140
cgaaaaatgc gatgatacga cttgctcaat cttatcttgt ggaggccaga tggactcttc 1200
aaaactacaa gccatcattc gaggagttta aggctaatgc attgccaact tgtggttatg 1260
ccatgcttgc tattacatct ttcgttggca tgggagatat tgtaacacca gaaaccttta 1320
aatgggcagc caatgaccct aagataattc aagcttccac aattatttgt aggtttatgg 1380
atgatgttac tgaacacaag ttcaaacata ggagagaaga cgattgctca gcaattgagt 1440
gttacatgga agaatatggt gtaacagcac aagaggcata tgatgtattc aacaagcatg 1500
ttgagagtgc ttggaaggat gtgaatcaag ggtttctgaa accaacagaa atgccaacag 1560
aagttttgaa tcgtagctta aaccttgcaa gggtgatgga tgtactctac agagaaggtg 1620
atggctacac atatgttgga aaagcggcta agggtggaat cacttcatta ctcattgaac 1680
caattgcact ttgaaatcgt attaaatttt cctcttcagt tccttaagga atagttatta 1740
agttataatt aataatgttt tataatattc atatatatat tataaaagaa agtttaaatc 1800
aactgtcttt gtattcattt ccttgtattg atccaataaa gttcttttca a          1851

<210> 590
<211> 5450
<212> DNA
<213> Gossypium hirsutum

<220> 
<223> (+)-delta-cadinene synthase

<400> 590
gttggtcaaa gggctttgtt ggtcaaaatt gtcaattcaa ggattcaatt gagtagaaga 60
ggttccgagg gatttaatta ttttttttaa agttaaaatt cttaataagc ccatattatt 120
ttgattaatt ctatcagtca tctctaattt attgccaata gtcttatagc ataatgtcaa 180
atttagccac catatttata tattttgtca atttaactct ttttcttatt ctttttagct 240
aaatttgccc ttagtctttt aaaaaagagt caaaaaattt gtttaaacaa aaatcctaac 300
taaaacatta atttttcaac aaagttgaca tggaaacttg tgttacagac cacatgtact 360
tcatgtagac ataactctat ttattatatg ccacaccaac aagtaattta aaaattacaa 420
aaaaaatcaa aaaaataaat aataataata atatggagta catgtggatt agtatgtgag 480
ctgccatgtt taaaaattta acggtttatt ttcattaaaa aaatagcatt tcaactattt 540
ttgaaaggtt taaggttaaa tatgattttt tttaaaaggg tgaggaccaa ttttagctaa 600
aaaaataaaa gtcaaattaa caaaaaagaa tgtaaatgtt gagaactaaa tttaacgtta 660
tgcctattct taattagttc taaacttcaa aataggttaa ttaaatcttt aaaatattag 720
cattgtatct atgcaataaa ttttaacgta ttaaaaaatt aatgtcaata aaatattatc 780
tatgttacag atagatacat ctttacaatt tgatctacgt atttcatata cactttaact 840
caagcttgag ttgacattta atgcctaaac taattgttaa gctaatggaa aggcttgatt 900
gatatgatac taatactttg cggattgaat taaaatattt ttaaaattta aaattgaatt 960
taaaatctgc ataatttgag aacattacgt catagtttaa tgtgtttatg gtaaattagt 1020
caatagtata atagtaaaca agttacgttg cctagtcctt gatcaaacct gacatgctct 1080
attataatag taaacattaa cttctcttta ctcagtttaa ttgtgggatt gtaattatca 1140
tttatgttgg ccttaaatcg taggattaga actatttaat ttgacttgat taattttcaa 1200
aattacatgc tatttcggtt taaaaattat tataaatatt ataaatatta taaatattac 1260
gtcatagttt atgtgttcat ggccaattag tcaataggat aatagtaaac aagtgacgtt 1320
gcttagtcct tgatgaaacc tgacgtgctc tattataaaa atcaatcaaa aagattagtg 1380
ggaagaactg agaaacaaaa gtctttgggt ctgaaacaaa tgcatgcacc gatctaactt 1440
tcagatgcct taaagattaa caatggttag gacttaaaag atcgttaaag attatttatt 1500
atttgaaaac aggtttcttg catttaatat attattaata aaattttatc gattttaaat 1560
atatataatt tttattaatt ttaaaaaata gttatattta tataaaaaaa aatagtattg 1620
ggttaattga ttaaattaaa aattggtggt ctgtctaatt ttgtacatac ccaagataga 1680
aaatacatat ctttattagc taattactac ttctttttta aggaactagt tactactttt 1740
tagacttatt taatatgaaa tcacatttaa catttaatta tgttttaatt aaataattta 1800
gttcagttgg tccaactgat ttaatttata ttttaattga ggctgaccgg ccgagggaag 1860
gactgaaatg atatatttct ataattctaa agttcaacag aggataaata tttactttgt 1920
aacacatttc tacacatttc atcttctaat attttacagg catcaacttt gaataagaga 1980
atcaaacaaa aagacaaatc aacatctctt ttaatctatt tgcaattctc atgcaatgag 2040
ccgccctaca ccaatcttat tgtataattg tttccttgca tataggttgt cttttttgac 2100
ttaaactcac cagtatattt tacctataaa tacatgcaac aattgcactc ttatcctcac 2160
agattctgtg ccaaatttca agagcaaacc aaaaaaggca gcaaattaag cttttcaata 2220
tttgctttta atcaatcgaa atggcttcac aagtttctca aatgccttct tcatcacccc 2280
tttcttccaa taaggatgaa atgcgtccca aagccgattt tcagcctagc atttggggag 2340
atttcttcct caattgtccc gacaaggtat acatacatat gaccatattg gtatatatat 2400
aatcttaaca gattatttgt ttagttattt agtgattcaa tatgaagcaa attttcatta 2460
ttttgagcag aatattgatg ctgaaactca aaaacgccac caacaattga aagaagaagt 2520
gaggaagatg attgtggcac caatggctaa ttcaacccaa aagttagcct tcattgattc 2580
agtccaaaga ctgggtgtga gttaccattt caccaaggag atcgaagatg aactagagaa 2640
tatctaccat aacaacaatg atgccgagaa cgacctctac accacatccc ttcgattccg 2700
actactccga gagcatggat tcaatgtttc atgcggtaat tactggaaca acaacatggt 2760
atttttaagt ttcttgagta tataatagca tggaatgttt gataacaata tttcattttg 2820
ggtaatttca tctcagacgt attcaacaag tttaaagacg agcaagggaa tttcaagtca 2880
tccgtgacaa gcgatgttcg aggattgttg gaactttacc aagcttccta tttgagggtt 2940
catggggaag atatattgga tgaagcaatt tctttcacca gcaaccattt aagccttgca 3000
gtagcatctt tggaccatcc tttatccgaa gaggtttctc atgctttgaa acaatcaatt 3060
cgaagaggct tgccaagggt tgaggcaaga cactatcttt cagtatacca agatattgag 3120
tcccataata aggttttgtt ggagtttgct aagatcgatt tcaacatggt acaacttttg 3180
catagaaaag agctaagtga gatttctagg tatgtttttg aatctctttc acgcattttt 3240
ttttcttttt tgtctttttt tttttggtgg aaggagggtt gaatttaatc gcggcatcat 3300
tctcaatata ggagacgagt tgcaaatgct aatatttgaa tcttaatata tagcacaagt 3360
taaaagtgat ggattcatct ttttcactta cattatttta cttatattat ataagttata 3420
tatatatttt aaaatttcag gttgccaatt tacttaagaa tctaacaatt tacttattga 3480
caacatgaat gtgaaacaaa ttaaaacttt gaatattcat tttgctaatg gggttttcta 3540
tgatatgatt tttttaggtg gtggaaggat ttagactttc aaagaaagtt gccatacgca 3600
agagatagag tggttgaagg ctatttttgg atctcaggag tgtactttga gccccaatat 3660
tctcttggta gaaagatgtt gacaaaagtg atagcaatgg catctattgt agatgataca 3720
tatgactcat atgcaacata tgaagagctc attccctata caaatgcaat tgagaggtta 3780
gatttctaaa attttgttgg taataggtta ggtttcttta gttgaagtta acattgaagt 3840
tgaattcagg tgggatatca aatgcataga tgaacttcct gaatacatga agccgagcta 3900
caaggcacta ttagatgttt atgaagaaat ggaacaactg gtggctgagc atgggagaca 3960
atatcgtgtc gaatatgcga aaaatgcggt atgtacatca acaaacattt attttgtaca 4020
aaagagataa gatcttagct aaattctaga tttgaataaa caactaactt gaataacaat 4080
atataatcat ttaaatatta ttattgaatt tgaattgata ttagtgataa ttgttgggat 4140
tttgtcgcct cagatgatac gacttgctca atcttatctt gtggaggcca gatggactct 4200
tcaaaactac aagccatcat tcgaggagtt taaggctaat gcattgccaa cttgtggtta 4260
tgccatgctt gctattacat ctttcgttgg catgggagat attgtaacac cagaaacctt 4320
taaatgggca gccaatgacc ctaagataat tcaagcttcc acaattattt gtaggtttat 4380
ggatgatgtt gctgaacaca aggtataata atatatttaa ataatcacaa gaaaccaaac 4440
tattaactca ataacgatgg tttttgtcat gatttgaaac aattaaagtt taatgtttat 4500
atatcaaatg tttagcctta aatcgaagaa taagaaaaga tatctagttt cattttaaaa 4560
atatatatag tttaacaaac gaatagaatt taggttatat agtaattgaa taatttttat 4620
tttattatgg ttgcagttca aacataggag agaagacgat tgctcagcaa ttgagtgtta 4680
catggaagaa tatggtgtaa cagcacaaga ggcatatgat gtattcaaca agcatgttga 4740
gagtgcttgg aaggatgtga atcaagagtt tctgaaacca acagaaatgc caacagaagt 4800
tttgaatcgt agcttaaacc ttgcaagggt gatggatgta ctctacagag aaggtgatgg 4860
ctacacatat gttggaaaag cggctaaggg tggaatcact tcattactca ttgaaccaat 4920
tgcactttga aatcgtatta aattttcctc ttctgttcct taaggaatag ttattaagtt 4980
ataattaata atgttttata atatatatat tataaaagaa attctaaatc aactgtcttt 5040
gtattcattt ccttgtattg atctaataaa gttcttttca agctttcatt tgtgaaaaat 5100
ctgctctttt atattttata ttttaatttt ccttctttcg ttgctatagc tttgaacaca 5160
aaatttagag tatgatccta tcatgctctt cctttttacc aacattgttg tcactttcaa 5220
tgatttttct cttcttcgcc ataacattat catcaagatt gcatgtgata aagttttgcc 5280
attcagatag ccttttcaag gctcgccact agaagctcac ttaaataggg atacttgtta 5340
ataaaatatt tttgttgtcc ttgtttctag gcatatagtt gttgcacatc aaggatttag 5400
tggctacaaa tcatgggttt atttggttta gatttttttc cttagttgtt            5450



<210> 591
<211> 1820
<212> DNA
<213> Gossypium hirsutum

<220> 
<223> (+)-delta-cadinene synthase

<400> 591
caagtttctc aaatgccttc ttcatcaccc ctttcttcca ataaggatga aatgcgtccc 60
aaagccgatt ttcagcctag catttgggga gatttcttcc tcaattgtcc cgacaagaat 120
attgatgctg aaactcaaaa acgccaccaa caattgaaag aagaagtgag gaagatgatt 180
gtggcaccaa tggctaattc aacccaaaag ttagccttca ttgattcagt ccaaagactg 240
ggtgtgagtt accatttcac caaggagatc gaagatgaac tagagaatat ctaccataac 300
aacaatgatg ccgagaacga cctctacacc acatcccttc gattccgact actccgagag 360
catggattca atgtttcatg cgacgtattc aacaagttta aagacgagca agggaatttc 420
aagtcatccg tgacaagcga tgttcgagga ttgttggaac tttaccaagc ttcctatttg 480
agggttcatg gggaagatat attggatgaa gcaatttctt tcaccagcaa ccatttaagc 540
cttgcagtag catctttgga ccatccttta tccgaagagg tttctcatgc tttgaaacaa 600
tcaattcgaa gaggcttgcc aagggttgag gcaagacact atctttcagt ataccaagat 660
attgagtccc ataataaggt tttgttggag tttgctaaga tcgatttcaa catggtacaa 720
cttttgcata gaaaagagct aagtgagatt tctaggtggt ggaaggattt agactttcaa 780
agaaagttgc catacgcaag agatagagtg gttgaaggct atttttggat ctcaggagtg 840
tactttgagc cccaatattc tcttggtaga aagatgttga caaaagtgat agcaatggca 900
tctattgtag atgatacata tgactcatat gcaacatatg aagagctcat tccctataca 960
aatgcaattg agaggtggga tatcaaatgc atagatgaac ttcctgaata catgaagccg 1020
agctacaagg cactattaga tgtttatgaa gaaatggaac aactggtggc tgagcatggg 1080
agacaatatc gtgtcgaata tgcgaaaaat gcgatgatac gacttgctca atcttatctt 1140
gtggaggcca gatggactct tcaaaactac aagccatcat tcgaggagtt taaggctaat 1200
gcattgccaa cttgtggtta tgccatgctt gctattacat ctttcgttgg catgggagat 1260
attgtaacac cagaaacctt taaatgggca gccaatgacc ctaagataat tcaagcttcc 1320
acaattattt gtaggtttat ggatgatgtt gctgaacaca agttcaaaca taggagagaa 1380
gacgattgct cagcaattga gtgttacatg gaagaatatg gtgtaacagc acaagaggca 1440
tatgatgtat tcaacaagca tgttgagagt gcttggaagg atgtgaatca agagtttctg 1500
aaaccaacag aaatgccaac agaagttttg aatcgtagct taaaccttgc aagggtgatg 1560
gatgtactct acagagaagg tgatggctac acatatgttg gaaaagcggc taagggtgga 1620
atcacttcat tactcattga accaattgca ctttgaaatc gtattaaatt ttcctcttct 1680
gttccttaag gaatagttat taagttataa ttaataatgt tttataatat atatattata 1740
aaagaaattc taaatcaact gtctttgtat tcatttcctt gtattgatct aataaagttc 1800
ttttcaagct ttcatttgtg                                             1820

<210> 592
<211> 5351
<212> DNA
<213> Gossypium hirsutum

<220> 
<223> (+)-delta-cadinene synthase

<400> 592
catgtgtggc catattagtg tagattccac atggccaggg acacggatgt gtgtccaagc 60
cgtgtaactc actgtttgtg gtacaaagcc acacagccag agacacgtgc atgtacccag 120
gctgtgtgag tcacacagac aaggacgggt gtgtatctag ttcatgtaac tcattgttta 180
tgctttggaa ccacacgagt gagacacatg gccgtgtgac ctggtcgtgt ggcatgttat 240
tagggctcga aacctgttct taaggccgaa aacattactt aacactaata ctggcctctt 300
caatgtacga ataattgaat ttgattatat gtgaactgtc tgatactcta agattgatct 360
gtgagctaca tagttatatg tatactataa tgcttattat gatgtcgaac tcttttattt 420
aattatgaaa tagattagaa tgactgaatg catgatacgg tatttgtgtt atgcattggc 480
atgggttggt attttgtgaa gaaggaagaa ttctattctg aaaatgtggc tacgccatac 540
tgatctagta gctaaactgc atctctgtaa aagtgtcaac gaacactcta aggtgtgcag 600
ggttggttgg gcattgaata tccctaaatg gtgtgttggg atggctgaaa acggtgtcta 660
gcgaatgggg ataggaatat tgcatctaaa tctgatctgt atcgtatatg atctgaaatt 720
gtatatatat atgtaactaa tctactctga atctgaactg aaattacttc tgtatcgaac 780
cgaatcccta aatttggaac tactttataa atgagtatta attgaataaa cttcttttac 840
gtaaagttta caactcattt tgatattgct tggatttcaa gtggttcgca gaactgaacg 900
ggtcgatgcc gcgagagctc ggtcaagctt ttagcttttt ttaaattatt tcgataagag 960
ttttgataaa ctataatagt atgactttgg aagattatat gtctaactaa gctttgtgtt 1020
aaattttatg tgaatcatgg tttggtatta ttgtgttttg tgtagtattt aagtattgat 1080
aatgtaactc tctaaacttg gactggatgc ctaggctggg tctagggtgt tacagttcta 1140
ttttccccca tctatactcg gtgcacaaat gagtttcaaa caaatgaacc ttgaggatac 1200
aatgaaaccc ggtgactatt tgcattttac attgatgaaa atagcccact aagcactgaa 1260
tagagtaaaa taagaaaatc aatttctata ataattttct acgactattc tttataaaac 1320
aatctaagaa aaatagaaga tggaggaaga atataaagat ctttgagaac tttttgctat 1380
atttttcaaa tggaatctca ctcttatttt taggaattct catatctctt tccaataagt 1440
gtcttttcta aataatcaca tctttagaag agatataatt attcaactaa tatctcttaa 1500
atagatataa ctattaaagt aagagataca attattcaat taacctctct taaataaaca 1560
taactattta agaaatactg tttgaatagt tataattctt tattaaaaaa atcaagtgat 1620
ataactcttc ataattagaa gatttaactt attattatga atagtcataa ctcttgatca 1680
ataactaaaa aaatataaat tttgattaat tacactattt tatttatagt tattaaaaca 1740
ctataaatat ttaaaaatat ttcaacatta caaacatcaa attcaaagtt aaaagaaaca 1800
aacaaacaaa aaataaataa atagtaaaat accccaaaga aaaacatagc atctcaatca 1860
atttgccatt ttccttcaat ggacactaca tgtattttat tccactaatt ttatcttgaa 1920
tttaaattgt cctttttttt atttaaaatc accaatattt atgtataaat acgttgaaca 1980
attgcactct tagactcgca caaaatttgt gttatctttc aagagtgaat caaactgaca 2040
acaaattaag catttgaatc ttgctttttc atcaaccgaa atggccaaac aagtttctca 2100
acttctttct tcatcacccc ttacttccaa caaagatgaa atgcgtctga aagccgactt 2160
tcagcctagc atttggggag atctcttcct tacttgtctc gacaatgtat acacacacat 2220
atatatataa gcatattgac atataatttt aacatattat ttgtttaatt atttagtgtt 2280
ttaatatcaa taaaatttgt attattatga acaggatatc gatgctgaaa ctgaacaacg 2340
ccaccaacag ttggaaggag gagtgaggaa gatgattgtg gcaccaatgg ctaattcaac 2400
ccaaaagtta accttcattg attcggtcca aagactgggt gtgagttacc gattcaccaa 2460
agagatcgaa gatgaacttg agaacatcta ccataacaac aatgatgccg aaaatgacct 2520
ctacactaca tctcttcgat ttcgattact ccgagagcat ggattcaatg tttcatgtgg 2580
taattattgg aagaagaaca tagtgttttt aagtttcttg agtatataat aacatggaat 2640
gtttgataac gatatttcct tttgggtaat ttgatctcag aggtattcaa caagtttaaa 2700
gacgagcaag gggattttaa gtcatcattg acaagcgatg ttcgaggatt gttggagctt 2760
tacgaagctt cgtatttgag ggttcatggg gaagatatat tggatgaagc gatttctttc 2820
actactgacc atttaaccct tgcagtagca actttagaat atcctttgtc tgaacatgtt 2880
tctcatgctt tgaaaaaatc aatccgaaga ggcttgccaa ggattgaggc aaggcactat 2940
ctttcagtat accaagatat tgaatcccac aatacggctt tgttggagtt tgctaagatc 3000
gatttcaaca tgttacaact tttgcatagg aaagagctaa gtgagatttg taggtatgtt 3060
ttttagtctt tttcaccctt ttattctctt tttcacaatt ttttttttga ggcatagggt 3120
tgaatttata ggaggggtca tctttagtat tggagacgag ttgaaaatgc taatattcaa 3180
atcttaaaca ttattaaata tcactagtta aaagtgatta tatgaacatt gaattcattt 3240
tttttcaact atttcatttt acttatatat tttaaaattt gaagttgcca atcgaactaa 3300
gaatctaaca atttacttgt caacaacatg aatgtgaaac taattaaaac tttgaagatt 3360
cattatagta atgaggtttt ttatgatatg attttttagg tggtggaagg atttagactt 3420
caaaagaaag ttgccatatg taagagacag agtggttgaa tgtttttttt ggatcctggg 3480
agtgtacttt gagccccaat attcacttgg tagaaagata ttgacaaaag tgatagctat 3540
gacttctgtt atagatgata catatgactc atatgcaaca tatgatgagc ttattccata 3600
tacaaatgca attgagaggt tagattttta taattggagg ttaaaattca attatattac 3660
aaggaatgat caaatataac cttaatttgg attcaggtgg gatatcaaat gcatagacca 3720
acttccagaa tacatgaaac tgagctacaa ggcattatta gatgtttatg aagaaatgga 3780
acaactgatg gctgaggatg gaagacaata tcgtgtagaa tatgccaaaa atatagtatg 3840
tacaccgaca aacatttatt ttgtacaaaa gagataagat attagctaaa ttctagattt 3900
gaataaacaa ttaacttgaa taacagcata taatcattta aatattattc ttgaaataaa 3960
aatatataat catttaaata ttattattga aattgatttg atattagtga taattgttgg 4020
gattttgttg acttagatga tacaacttgc tcaagctttc cttatggagg ccaaatggac 4080
tcttcaaaac cacaaaccat cattcgagga gtttaaggct actgcattgc aaactactgg 4140
ttatgccatg cttgctatta cagctttagt tgacatggga gatattgtaa caccagagac 4200
ctttacatgg gctgctaata accctaagat cattcaagct tctacaatta tttgtaggtt 4260
tatggacgat gttgctgagc acaaggtata ataatatatt tttataataa aagaatgaaa 4320
ttcttaactt aataattgaa tgtctttgta acaaaaccaa acgatggttt ttatcatgat 4380
ctaaaacaaa taaaatttga tttgtatgta tcaaatgttt agtcttaaac agaagaataa 4440
gaaaaaaatt ggtttcattt tagggttatt gtcaataaag ttattttatc atcactaaac 4500
aaatatagtt taatatactg acaagtgaag aataattttg atttttttac ggttgcagtt 4560
caagcagagg agagaagatg atttctcggg aattgagtgt tacatggaag aatatggcgt 4620
aatggtacaa gaagcataca atgtgtttta caagcatatc gagagtgcct ggaaggatgt 4680
gaataaaggg tttttgaaac caaccgaaat gccaatagaa gttttgaatc gtatactaaa 4740
tcttgcaagg gtgatgaatg tgctttacaa cgaaggtgat ggctatacat atgttgggaa 4800
agcaactaag ggtattatca gcatattgct cattgaaccg gtcactcttt gaaaattaca 4860
ataattttcc tcttcaagct tgttcttaag gggaaattat taggttctga ttataatact 4920
ctcatgtatt ccaaaataaa ttccaaattg tctgtctttg tactctttac ctttatgtta 4980
atccaataaa gatatttgcc accttttctt tgtgaaagtt ctcttttttt tttcctttaa 5040
ttttaatttt ttatgtattt agttattgtt ttttttgtat aaaataatat gtagtatgag 5100
aatagtaaga gttatggact attaaatatc atcttttaaa aatagttgta taaataaatt 5160
gaattaaatt tacaattttt atttttattt ttataaatga ttaagatcaa aataacaaaa 5220
aaaatctatt gaaaatcact gcttaaaatt cactacaaga ttgaaatata aaatgcactt 5280
agttaattac tacttaaaac ccatcaaatg tatagctatt tccaaaagat tagtaatcaa 5340
attcaagaga a                                                      5351



<210> 593
<211> 2986
<212> DNA
<213> Helianthus annuus

<220> 
<223> germacrene A synthase 1

<400> 593
atggcagcag ttggagccag tgctaccccc ttaacaaaca ccaaaagcac tgcagagcca 60
gtgcgtcctg tggccaactt cccaccttct gtatggggtg atttgttcct atcattctct 120
cttgacaaat cggtaaggtt tcccgctagc taattacaaa tttaagggcg gaaccaactc 180
accaaggggt caagagggtt tgctaatccc cggttactag aatttgttgg ttttttatat 240
taaaaaatat gagtgatagc ccctacaaaa aagtcaccat gtacaagata caatcgcatg 300
acgttatgta gttttttttt ttttccttaa gaaataaaaa taaggtgttt tcttttctag 360
ataatggaag aatacgctga agccatggaa gagccaaaag aacaagtgag aagattgatc 420
ttggatccta caatggattc aaacaagaaa ctgagcttga tttataccgt tcaccgtctc 480
ggtctgacat acatgttctt gaaagagatt gaagcccagc ttgacagact tttcaaagag 540
ttcaacttgg aagattatgt tgaacttgac ttatacacaa tttcgattaa ctttcaagct 600
tttcgacacc ttggttacaa gctgccttgt ggtacgtacc ggattctaac attaaatact 660
tgccactttt gcatcatcag tacttgtttt tttcacagag tccattatgg ttgccatcaa 720
atgatttaca atataagtta ctcatgtctt ctctttttca tgacataagt gatacaatat 780
tttatattaa tttgtgaccg aacagatgtg tttaacaaat tcaagaacga cgactcgact 840
acattcaagg aatctattac tggtgatgtg aggggtatgt taggcttata tgaatctgca 900
caattgagat tgaaagggga aaacattcta gacgaagcct cggcgttcgc ggaaactaaa 960
ctgaagagtt tggtaaatac tctggaaggc agtcttgcac aacaggtgaa acaatctttg 1020
agaagaccat ttcatcaagg gatgccaatg gtagaggcaa ggctatattt ctccaactat 1080
caagaagaat gctccgcaca tgactccata ctgaaacttg caaaacttca cttcaactat 1140
ttgcagctac aacaaaagga agaacttagg attgtttcac agtgagtcac ataacatcct 1200
atatattgga attaataatg atgcattatt tattaaaagt agataaaaac ataataaata 1260
ctcatatgaa aagggaaata tctatgaagc aacgtgtctt aaacccaacc gaaaacaaga 1320
gtacaaaata cacactcaca atatatgcaa tacaaactaa gaatttattg aagatgtgag 1380
aaattataaa agtgaaaagt tgatggaagt ttattctacc ttgtttcaca ggtggtggaa 1440
ggatatgagg tttcaagaga caactcctta tataagggat agagtgccag agatttattt 1500
atggatatta ggactctact ttgaacctag atactctttg gcacgaatca ttgccaccaa 1560
gattacgttg tttcttgtgg tgctagatga cacatatgac gcttatgcta ccattgaaga 1620
gatccgcctt ctaaccgatg caataaatag gtacaagtta taccaagtgt tgctttaaac 1680
catcatgcac ttcgaaataa aattactaat gcttgaagat ctctcgttat atatcaacat 1740
ttgatatttt aggtgggaca ttagtgctat gaatcaaatt ccagagtaca ttagaccatt 1800
ctacaagatt ctcctggatg agtatgctga acttgagaag caactagcaa aagaagggcg 1860
cgcaaatagt gttattgctt caaaagaagc ggtatgatcg atatgttata aattctggat 1920
ttttcatgta ctgattaacc tctttaatat agaggtgtaa ccaaattaca cgataatgat 1980
ataatgatag aacgccaata actatcataa cattcaaact agagataaaa taatattgac 2040
taacaaacaa agttaaagta tataaacagt agatcaaatt ataataacta taacagataa 2100
taaactagcc taacaatttg tatgttatgt taaatgaaaa tttcatctcc atagatattt 2160
tgttaatctt tggcttattg tatatctata tggagttcag ttccaagaca tagctagagg 2220
gtaccttgaa gaggctgagt ggacaaacag tggatatgtg gcatcatttc cagagtacat 2280
gaagaacgga ttaatcactt ctgcctacaa tgttatttcc aaatctgctt tagtgggaat 2340
gggtgagata gtgagtgaag atgctttggt ttggtatgag agtcatccac agattctgca 2400
agcttcagag ttaatttcaa gactccaaga tgatgttatg acataccagg taaacaatta 2460
aactggttta aaatgcaaag ttaacttata aacatcatgt attctcacta acactatgac 2520
tatttgttta agtttgagcg cgaaagagga caatccgcca caggtgttga ttcatacatc 2580
aagacctatg gcgtatcaga aaaggtagca attgacgagc tcaagaaaat gattgaaaat 2640
gcatggaaag aaataaacga ggggtgtctc aagccaagag aagtctcaat ggatttgctg 2700
gccccaattc ttaaccttgc tcgaatgata gatgtggtat acaggtatga cgatgggttt 2760
actttcccag gaaagacact caaagagtac attactctct tgtttgttgg ttcttcaccc 2820
atgtaataat ggaaatattg ttgcttgttg tggtgtatct ctaggacaat atctcaatcg 2880
tgatttttgt accgtataag gatattaata tattttgtaa cataatcgac attgtcgatg 2940
tatgaatatt tttatgactt ggtgtaagtg gatatgttat atacac                2986

<210> 594
<211> 1680
<212> DNA
<213> Helianthus annuus

<220> 
<223> germacrene A synthase 2

<400> 594
atggcagcag ttggagccag tgctaccctc ctaacaaaca ccaaaagcgc tgaagagccg 60
gtgcgtcctg tggccaactt tcctccttct gtatggggtg atttgttcct atcgttctct 120
cttgacaatt cgatgatgga agaatatgct gaagccatgg aagaaccaaa aggacaagtg 180
agaaaattga tcttggatcc tacaatggat tcaaacaaga aattgagctt gatttatacc 240
gttcaccgtc ttggtctaac atacatgttc tttaaagaga ttgaaggcca gcttgataga 300
cttttcaaag agttcaactt ggaagattat gttgaagttg atttatacac aatttcgacc 360
aactttcaag ctttccgaca ccttggttac aaactatctt gtgatgtgtt taacaaattc 420
aagaactacg actcgaatac attcaaggaa tctattacca gtgatgtgag gggtatgtta 480
ggcttatatg aatctgcaca attgagattg aaaggagaaa agattctaga cgaagcatcg 540
gcattcacag aaactaaact gaagagttta gtaaagactc tggaaggcag tcttgcacaa 600
caggtgaaac aatccttgaa aagaccattt catcaaggga tgccaatggt agaggcaagg 660
ctatatttct ccaactatca agaagaatgc tccagacatg actcactact aaaacttgca 720
aaacttcact tcaactattt gcagctacaa caaaaggaag aacttaggat tgtttcacag 780
tggtggaagg atatgaggtt tcaagagact actccttata taagggatag agtaccagag 840
atttatttat ggatattagg actctacttt gaacctagat actctttggc acgaatcatt 900
gccactaaga ttacgttgtt tctcgtggtg ctagatgaca catatgacgc ttatgctacc 960
attgaagagg tccgccttct aacagatgca ataaataggt gggatattgg tgctatgagc 1020
caaattccag agtacattag accattctac aagattctct tggatgagta tgctgaactt 1080
gagaagcaac tagctaaaga agggcgtgca aatagtgtta ttgcttcaaa agaagcgttc 1140
caagacatag ctagagggta ccttgaagag gctgagtgga caaacagtgg atatgtggca 1200
tcatttccag agtacatgaa gaacggatta atcacttctg cctacaatgt tatttccaaa 1260
tctgctttag tgggaatggg tgagatagtg agtgaagatg ctttggcttg gtatgagagt 1320
catccacaga ttctgcaagc ttcagagttg atttccagac ttcaagatga tgttatgaca 1380
taccagttcg agcgcgaaag aggacaatcc gccacaggtg ttgatgcata catcaagacc 1440
tatggcgtat cagaaaaaga agcaatcgac gagctcaaga aaatgattga aaatgcatgg 1500
aaagaaatca acgaggggtg tctcaagcca agagaagtct caatggattt gcttgcccca 1560
attcttaatc ttgctcgaat gatagatgtg gtatacaggt atgatgatgg gtttactttc 1620
ccaggaaaga ccctcaaaga gtacattacc ctcctgtttg ttggttcttc acccatgtaa 1680


<210> 595
<211> 1674
<212> DNA
<213> Helianthus annuus

<220> 
<223> germacrene A synthase 3

<400> 595
atggcagcag ttgacactaa tgccaccatc caagaaaaga ccaccgcagg gccggtgcgt 60
cctttagcca acttccctcc ttcggtatgg ggtgatcgct tcctatcatt cactcttgac 120
aattcggaac tcgaaggata tgcaaaagcc atggaagccc caaaagaaga attgagaaga 180
ttgattgtag atcaaacaat ggattcaaat aagaaactaa gtttgattta ttccgtccac 240
cgtcttggtt tgacatatct gttcttgcaa gagattgaag cccagctaga caaaattttc 300
aaagagttca acttgcaaga ttatgatgaa gttgatcttt acacaacttc tatcaacttt 360
caagttttcc gacaccttgg ttataaacta ccttgtgatg tgtttaacaa attcaaagac 420
aatacctccg gcgctttcaa ggaagatatt tctacggatg tgaagggcat gctaggctta 480
tacgaatctt cacaactaag aacaagagga gaatcgatac tagatgaggc ttcatcgttc 540
actgaaacta aactcaagag tgtagtaaac aatcttgaag gaaaccttgc acaacaggtg 600
ttacaatcat tgaggagacc atttcatcaa gggatgccaa tggtggaggc aaggctatat 660
ttctccaact atagtgaaga gtgtgccaca catgagtgtt tattaaagct tgcaaagctg 720
catttcagct atttggagct acagcaaaag gaagaacttc gcattgtctc aaagtggtgg 780
aaagatatga gattccagga aactacacct tatataaggg atagagtacc agagatttac 840
ttatggattt tgggattgta ctttgagccc cgttactcct tggcacgaat catcgccaca 900
aaaattacat tgtttcttgt ggtgctagat gatacatatg acgcttacgc taccattgaa 960
gaaattcgac ttttaactga tgccataaat aggtgggaca tgagtgctat ggagcaaatt 1020
ccggaataca ttagaccatt ctacaaaatt ctcctagatg agtatgctga gcttgagaaa 1080
caactagcta tagaaggaag agcaaagagc gttattgctt caaaagaagc gttccaagac 1140
attgctagag gctaccttga agaagccgag tggacaaaca gtggatatgt ggcatcattt 1200
cctgagtaca tgaagaatgg gttaatcact tcagcctaca atgttatttc gaaatctgct 1260
ttagtgggta tgggcgacat agttagtgaa aatgcattgg catggtacga aagtcatcca 1320
aagactctac aagcttccga gttaatctca agactccaag atgatgtcat gacttaccag 1380
tctgagcgtg aaagaggaca atcagccact ggagttgatg cgtatatcaa gacatacggc 1440
gtgtcagaga aggaagctat tgatgagcta aagataatga ttgaaaatgc atggaaagat 1500
ataaacgagg gatgtctcaa gccaagagaa gtctcgatgg atttgctcgc gccaattctt 1560
aaccttgcaa gaatgataga tgttgtgtat cgatatgatg atgggttcac ctttcctgga 1620
aaaaccatga aagagtatat tactctttta tttgttggtt ctgtatccat gtaa       1674

<210> 596
<211> 1944
<212> DNA
<213> Helianthus annuus

<220> 
<223> gamma-cadinene synthase

<400> 596
gataagccgc gttcgttgca ccaactccca ttccacaaat ggcaacaact gaagctaaca 60
ctatggcgca agctaactca caaaccacca tagagccggt gcgtcatctg gcaaactttc 120
cgccttcgat ttggggtgat cagtttctat cattctctct tgataattcc caattggaag 180
catacagtaa agctatggag cagccaaaag aaaacgttag aagaatgata ttaaaccctg 240
ctattgatac aaatgagaaa ttgggtttga tttattgtgt ctatcgtctt ggtttgacgt 300
ataatttctc aaaagatatt gatggtcaac ttgatgaact tttcaaacag cttaacttgc 360
aaagttacaa cgaagcagat ctctatacaa tatccattca ctttcaagtt tttagacact 420
ttggttatag attttcttgt gatgtgttta acaagttcaa ggactccagt tctggtaaat 480
tcaaggaaga catgactaga gatgtgaggg gtatgataag tttgtatgag agtgcccaac 540
taagaataag aggagaatct atactagatg aagccggtgc attcgcagaa agtaaactta 600
aaacgataga aaaaacactt gatggtacac ttgcacaaca agtcaaacat gtattggaga 660
gaccttttaa tcgagggcat cagatggttg aagcgaggaa gtatttgttc ctatttgaag 720
aagaaatttc acggtatgat tccctattga tgcttgcaaa ggtgcatttt aactacttgc 780
aactcctaca aaaggaagaa cttcgatctg tatcaaagtg gtggaaagac ttggacctac 840
cggcgaaaac actatatgta agagatagag tacctgaact ctatgtatgg attttggcgt 900
ttttcttgga gccgtattac tctgaagtcc gaataataac gaccaaaatc gtactgcttg 960
tattggtgtt agatgacacg tatgatgcat atgctactat tgaggagagc cgacttctaa 1020
cccatgcaat aaataggtgg gaagttagtg ctatgttgca acttccagaa tacatgaaac 1080
cattgtatga aattttgctc aacgagtatg atggatttta caaacatgga agaacaaatg 1140
tcattgagac ttcaaaaaaa gctttccaag acttggctag aagttaccat caagagtctg 1200
aatggagaca tgctaaagag gtgccatcat ttgaagagta tatgaaaatt gggacaacta 1260
cttctgcaca taatgttctt agtaagactg cattgattgg tatgggcaac attgtaacac 1320
gcgaggcttt agcttggtac gaaagctatc caaagatcgt acaactttca gagttgatcg 1380
gaaggctcga agatgatgtc gtcagtgttg agtttgagcg tgaaagagct ccaacagcca 1440
caagtgtaga tgcttatatg aagacttatg gggtgtcgga aaatgtagct gtcaagatac 1500
tcaaaaaact tgttgaaaat ggatggaaag atctaaatga ggcgtgtcta aagccaacag 1560
aggtctcatt ggatctgctt gctccgatta ttggtcttac aaacatgaca gacgtggcgt 1620
acaggcacaa tgatggttta acttttccag aaaagactct taaggaatat attacactcc 1680
tgttttgtgt tccagtcccc atgtaacaac tagtgtgtta gttcgtgttg ttgttcttct 1740
ctttcgcttt tgttttgttt ctccagtttc ttactggctc tctatatata aacatatagt 1800
gtggttgccg tttaaaaaaa acaactagtg tgttagtggt tacttaccga cgcatatgta 1860
tcttggttta acgtaaggat gaataactga tatctaacta gtgggtatcc ttattagtgt 1920
ttaaaaaaaa aaaaaaaaaa aaaa                                        1944

<210> 597
<211> 1750
<212> DNA
<213> Hyoscyamus muticus

<220> 
<223> premnaspirodiene synthase

<400> 597
gttgacaatc aggttgcgga aaagtatgct caagagattg aaactttgaa ggaacaaaca 60
agtactatgt tgtctgctgc ttgtggaaca acattgactg agaaattgaa tttgatagat 120
attattgagc gccttggaat agcttatcat ttcgagaaac aaatagaaga tatgttggat 180
cacatttaca gagctgatcc ttattttgag gctcatgaat acaatgattt aaacacttca 240
tccgttcaat ttcgactact cagacaacat ggttacaacg tctctccaaa tatatttagc 300
agattccaag atgcaaatgg caaattcaag gagtctctta gaagcgacat caggggccta 360
ctgaacttat acgaagcttc acatgtaagg actcataaag aggatatttt ggaagaagca 420
cttgtttttt ctgttggtca tcttgaatct gcagctccac atttgaagtc acctctgagt 480
aagcaagtga cacatgccct cgaacaatct ctccataaga gcattccaag agtcgagata 540
cggtacttca tctccatcta cgaagaggag gaatttaaga atgatttgtt gcttcgattt 600
gctaaattgg attacaactt acttcagatg ttgcacaagc atgaactcag tgaagtatca 660
aggtggtgga aagatttgga tttcgtgaca acacttccat atgctaggga cagagcagtt 720
gagtgctact tttggacgat gggggtgtat gctgaacctc aatactccca ggctcgtgtc 780
atgcttgcta agactatagc aatgatttcc atagtagatg acacattcga tgcttatggc 840
atcgtaaaag aacttgaagt ctacacagat gccatacaga ggtgggatat tagtcaaatt 900
gatcgactcc cggaatatat gaaaatcagt tataaggctc ttttggatct ctatgacgat 960
tatgaaaagg agttgtcaaa ggatggtaga tccgatgttg tccactatgc aaaagaaaga 1020
atgaaggaga ttgtgggaaa ctattttatt gaaggaaaat ggtttattga gggatatatg 1080
ccatctgttt ccgagtacct tagcaatgca ctagctacta gcacatatta cttgctaact 1140
acgacatcct acttgggaat gaaatcagca accaaggaac attttgaatg gttggctacg 1200
aaccctaaaa ttctggaagc taatgctaca ttatgccgag ttgttgatga catagccacg 1260
tatgaggttg agaagggtag gggtcaaatt gcaacaggaa ttgagtgtta tatgagggat 1320
tacggtgtat ccacagaagt agcaatggag aaattccaag aaatggctga catagcatgg 1380
aaggatgtaa atgaagaaat tcttcgacca acacctgtct cttcagaaat tcttactcgt 1440
attctcaacc tggctcgaat tatagatgtc acttacaagc ataatcaaga tggatacact 1500
catcctgaaa aagtactaaa acctcacatc atcgccttgg tggtggattc tattgatatt 1560
tgaatcacca attgttgtgt acacctggga gcacttggtt cccaccccct caaataagtt 1620
tttgacagac acttgatgga tggtatctct gttgctaggt atacatgttg taatcgtgca 1680
gtgaagttac gtccttaatt cttttgtatg attatttaca tttgaaatat aataattctg 1740
ctttttaact                                                        1750

<210> 598
<211> 1273
<212> DNA
<213> Hyoscyamus muticus

<220> 
<223> vetispiradiene synthase

<400> 598
ctccataaga gcataccaag agtcgagaca cgctacttca tcaccatcta tgaggaggag 60
gagttgaaga atgatgtgtt gcttcgattt gccaaattgg atttcaattt acttcagatg 120
ttgcacaaac aagaactcac ggaagtatca atgtggtgga aggatttgga tttcgtgaca 180
acacttccat atgccaggga cagagcagtt gagtgctact tttggaccgt gggagtgtat 240
gctgaacctc aatattctga agctcgtgtc atgcttgcta agactatagc aatgatttca 300
atagtagatg acacatttga tgcttatggc attgtaaaag aacttgaggt ctacaccgat 360
gccatacaga ggtgggatat taaccaaatt gaccggctcc cagattacat gaaaatcagt 420
tacaaagtac ttttagatct ctacaaggat tatgaaacag agttgtcaaa ggatggcaga 480
tccgaagttg ttcactatgc aaaagaaaga atgaaagaaa ttgtgagaaa ctattttgtg 540
gaagcaaaat ggttcattga aggatatatg ccacctgttt ccgagtatct taacaatcga 600
ttagcgacta gcacttatta cttgcttacg acaacatcct acttgggcat gaagtgtgct 660
aacaaggaag attttgagtg gttgactaag aaccctaaaa ttcttgaagc caatgtgacc 720
ttatgtcgag tcattgatga catagcgacc tatgaggttg agaagggtag aggtcagatt 780
gcaactggaa ttgagtgcta catgagagat tatggtgtat caacagaaga ggcaatggaa 840
aaatttcaag aaatggcaga gatagcatgg aaggatgtaa atgaaggaat ccttcgacca 900
actcctgtct ccgcaaagat tcttactcgt attcttaatc ttgctcgcat tattgatgtc 960
acttatttgc acaatcaaga tggatacact catcctgaga aagtactaaa acctcacatt 1020
atcgccttgg tggtggactc tattgaaatt taaatcttca attgttgagt acatcttgga 1080
gcacctggtt ctcgctccct caaagaagta ttttcatcga catctgatgg atgccttgtt 1140
ggtattttgt tgttagctag agtaggtagg agttgctgac tatatatgtt cttatcgtgc 1200
agtgaaattg ccttcttaaa ttattttgta tcattacgga aatttgaatt atattaatgc 1260
ttcttttaca aga                                                    1273

<210> 599
<211> 1956
<212> DNA
<213> Ixeris dentate

<220> 
<223> germacrene A synthase

<400> 599
gaaagcaacg aactccagca atcactcctt caaaaatctc atcataaaat ggctctcgtg 60
agaaacaaca gcatcaacgg tcgtgaacca gttctcagtc ccaggagcct cactagcccc 120
cgtggcttaa ccagcccccg gccactggct gtccaaccga ctcctgagcc agttagacct 180
ttggccaact tcccgccttc aatatgggct aatcgtttca tctcattctc tcttgataac 240
tctgaattgg aagcttacgc aaatgcacac gaggagccta aagaatctgt caggagtttg 300
ataaccgata ccaccattga tgcatctgca aaactaaagt tgatctactc agtgcaccgc 360
cttggtttat cgtatcttta tcccgaagag atcgatgctg agcttgacca actcttcaag 420
aaaatcgact tgcatcatta cgaacaagtt gatttgtaca ccatttcagt acaatttcaa 480
gttttcagac atcatggtta taaattatca tctgacatat ttaaaaaatt caaggacacc 540
acaacgggta cattcacaga cgaagtcaca aaagacgtga aaggtatgtt gagtttatac 600
gaatcagctc acttgaggct acacggtgaa gaaatcttag atgaagcttt ggtattcacc 660
gaggcccaac ttaaaaaaat cgtgagcaca cttgagggag atcttgcaaa ccaagtgaac 720
caagtcttga aaagaccttt ccacaccggg atgccaatgg tggaggcgag actatatttt 780
aacacgcacg aagaagatgt ttcgtgttat gaatcgattg taaagttagc taaagtccac 840
ttcaactatt tgcaacttca acagaaggaa gaacttcgta tcgtgtcaca gtggtggaaa 900
gatatggagt ttcagacatc ggttccttac ataagagata gagtaccgga gatataccta 960
tggattttgg ggttatactt tgagccatat tactctcggg cacgtatcat agcaacaaaa 1020
atcacgttgt tcttggtggt tttagatgac acgtatgacg cgtatgctac aattgatgag 1080
atccgagcga tcacggatgc gattaatagg tgggaaatga gtgcaattga tttgcttccc 1140
gagtacatca aaccattcta ccgaattctc ctaaacgagt acgatgatct ggagaaagaa 1200
tactctaagg atggaagagc cttcagtgtc catgcttcaa aacaagcgtt tcaagaaata 1260
gcgagagggt atcttgaaga ggcggagtgg ttacacaatg gttatgtggc gacatttccc 1320
gagtacatga agaacgggtt gattacttcg gcttataatg tcatttcaaa atccgcattg 1380
gtgggaatgg gcgcgattgc agatgaagag gctcttgctt ggtatgaaac acatcccaaa 1440
attctaaaag cttcagagtt gatttcaagg ctacaagacg atgttatgac ttttcagttt 1500
gagaggaaac gaggacaatc ggctacgggt gtggatgctt acatcaagga atacaatgta 1560
tcagaagaag tggcgatcaa agatctcatg aagatgattg aaaacgcatg gaaagatata 1620
aacgaaggat gcctaaagcc tacagaggtc tctgtggctc tactaactcc cattttgaat 1680
cttgcaagaa tgatagatgt ggtatacaag ttcgatgatg ggttcacttt tcccgggaaa 1740
accttaaaag actatattac ccttctgttc gttacccctg cacctagtct tgaaagctgc 1800
taggttgtaa tacaagcatt acattttctt ggaactttgc tttttatgtt gacgcgtatg 1860
tttgcgctcg atatggtgaa ttttttaaac attctgttgt actattctcg ttgccaaata 1920
aagcaaattt ttttgttaaa aaaaaaaaaa aaaaaa                           1956

<210> 600
<211> 8487
<212> DNA
<213> Kitasatospora griseola

<220> 
<223> diterpene cyclase-2

<400> 600
ggatcccgag gagggagcga acgtgcaggt gcgcagagta cgagcacatg cctgaaggca 60
ggtcgtaccg ggccgggcgc tcacccgact acctgcgggg tgatcggcaa agatgtcgaa 120
aactcgttgc ttgctttgaa agcgcaaaga ccggtccgta ggctcggccc cactcaagag 180
cccgacatga agccggctca aggagattcc cccaagtcct cgtgacaacc ctggaggtac 240
cccatgacag atcaactctc cgctgccgac ttgccacgca cgtcggaacc gactttccgg 300
cggatcccgg tgctgctgat gctggttacc tgccagctga tgctggtcat cgacgccacc 360
gtgctgaatg tggcgttacc acatattcaa atcgatctcg gcttcacctc caccggtctc 420
tcctgggtcg tgaacgccta cattctggtt ttcgggtgcc tgctgctgct gggcgggcgg 480
gccggtgacc tgttcggtcg acgccgggtg ttcgtggcgg gagtcgccgt gttcacgtgc 540
gcctcgctgg ccgccggcct cgtcgactcg gccgctgcgc tggtgatcgc cagggttgtt 600
caggcgatcg gcgccgccgc cgccggaccg aacgcgcttg cgctcatcac caccaccttc 660
accaaggaag aggatcggca ctggtccctc gcctggttct ccgcgatcgc cagtgggggt 720
tttccgatcg ggttgatcgt cggcggtctg ttcaccgact ggctgtcctg gcgggcggcc 780
atgttcatca atgtgccgat cgggctcgcg atcgccctgt tgaccccgcg attggtgccc 840
gccccgaccc gtcatgcggc ccgcctcgac ctgccgggcg cgatcaccgc gaccggtggt 900
gtcgcggcac tgattttcgg gcttctacgg gccgccgagc ggggttggag cgatgggccg 960
accatcgccg cgctgggcat cgggctggtt ctcgtcgcag cgttcctggc catcgagtcg 1020
cgcaccgggc agcctctgat gccgctgcgg gtgttcgccg accgtgaccg tgccgcagcc 1080
tatgtgatca cgttcctgat ggcgatggcg atgatctcga ccttcttctt cctcacccag 1140
ttcctgcaga acgtgctcgg atggaatgcg ctcgtcaccg gattcgcgtt cctgcccatg 1200
gcgctcggcc tggtcgtcac cagtcgcctg accgcccggc tgctgccccg gctcggaacg 1260
aaatggctca tggtcatcgg tgcctcgctg atcgccgtcg gcatggtctg cctcacccag 1320
ctgtccaccg acagtgggta cctgtccgga ctgctcgtac cgatgctgct gctgggcatg 1380
ggcatcgggt tcacgttcgc cacggccaac gtggcgatca tgtcgactgt ggaggcgcag 1440
gacgccggcg cggcaggcgg tgtcctgcag accatgcagg aggtgggctc gtcggtcggg 1500
ctcgccgtgc tcatcaccgt cttcggtttc gcgaccggcc acgcacgtgt cctcccgcac 1560
ggactcctgg tcgacggaat ggccgtggca ttcgccggcg cggccgtctt cgccgcctgc 1620
ggcatcgcgg cggcgttcgg tatccggcac aggcagtcgg cggacacctg accggtcggg 1680
ggcgatgcgc ggagggccgg cggggcgagc accgtccgac cggctctaca cgccggtggc 1740
gccgtcgatg cgttcccgga ccaggtcggc gtgcccgttg tggcgggcgt actcctcgat 1800
catgtggacg tagatccagc ggaggctgac gtcctggtcc atgaatcggc cggtgttgga 1860
cagcgcacgg ccgacggagt gctcgcgggc gcggacgact tccgcctgcc acatggcgag 1920
agtgtcctgc agagtgacgc cctcgcccag ttcgaaaccg ccgtccgggc cgtccgggtc 1980
ggcctgcggg tcgtagatgg gtgggacttg ttctccggcg agcacccggc ggaaccagtt 2040
ccgctccacc tccgccatgt gctggaccag gccgatcagt gtgaagccgg acggcggcac 2100
tgacgcgacg gcggcctgct cgtcgtccag gccttcgcac ttcatggcga gcgtggcgcg 2160
gtggaagtcg agccaactct cgagcgtggt gcgctcgtcg gcgttcaagg gcggtaccgg 2220
gcgttcggcg gtgctcaccc gaccaagtat cggtgaccgt cggccgaatc cgtcggctga 2280
cagggcctgt cagcagggcg aacagttgtc cagtgcagac gagtggcgat ccgagagtga 2340
tgcgccggca aagcccttgc cagaacgtcc agttgagctt gactgtgaca cgtcatgaag 2400
cctagagtgc tgcgtatcag taccaccggg ctgtcgttca tgaaagttgc actatcagcg 2460
actggagaga tgcgctagat ggctgactta gagaccaagt ttcccaggta cgaactgatc 2520
tcgtccggca agtacgtgga ccgcattcca gagctccatg aattacgcga gaaatccccc 2580
attgcctggg ttccggtcat ggacgcagct tttctcactc gacacgccga tatcgtccga 2640
gtgctgaaag accaccgcat ggccccggcc aacctgacac agggcatacg gctgctcagc 2700
cccgaacagc aagaggaatt ggagccgctg agcagcgccg tcaagaagtg gatggggcac 2760
accgttcccg cggatcatca gcggttcatc gggttgctga agcgctactt caccccggcc 2820
atgatcgatc ggatgcggcc gcgcgtgcgg cagctgtcgc acgaactgct ggacgcggtg 2880
gagccggccg ggcgcatgga catcgtttcc gacatcgcgt atccgctgcc cgcgtgcgtc 2940
atcgccgaga tgctcggcgt gcccatggac aacagggcac aactgctcgc ctggtcggcc 3000
gacatcgggg cgatcgccga aatcgtcagc tatgaccggc tcatggagtg ccagcggagc 3060
ctgctggcga tgcaggactt cgtcctggag gtggtcaagg agcgccgggc ggagcccaag 3120
gacgacctga tcagcatgtt cgtcgccgcc gaacgcgagg gcctcgtgag cgaggcggag 3180
atcctctcca actgcgtgat gctgctcttc tccgggcacg agaccaccgg cggactgatc 3240
accagtggcc tggtccagct cttcgatcac cctgatcagc tggagctgct gaagtccgat 3300
cccgacctga tgccgggtgc ggtcgaggag atgctccggc tcgccggacc ggcttcggtg 3360
atctcacggg tcagtaccga gcctgtcgag gtggctgggt catcaattcg aagcggggca 3420
gcagttcctc ctggcgctga tggcgggaaa cgcgacccgc gggtattcga ggacccggac 3480
cgcttggatg ccacccggcg tccgaacgac cacctcgctt tcgccaccgg catgttctac 3540
tgcctcggcg cggcgctcgc acggatggag gcggacgaat tcttcaggat tctgttggac 3600
cgcttccccg acgtcaatcc cggatacgaa actcctgact ggcagccggt gctgctcatc 3660
agccgacgct tgaagacgct ccccgtcaat ctgcggggtg tcggcggaag cggtgccggc 3720
gatgagtgac gccgatcgga tagcggccct gttgaaggac cgcgctgccg acccggtgac 3780
gaagttcagc ccctcgccgt acgagaccgg acagttcctg cggatatccg agcgggcgga 3840
cgtgggcaca ccgcagatcg actacttgct cgcgacgcag cgaccggacg gcctgtgggg 3900
atcggtcggg ttcgagctgg taccgacgct gggcgcggtg gcgggtctgt cctcgcggcc 3960
cgaatacgcc gaccgggccg gagtgacgga cgccgtggcg cgggcctgcg aaaagctctg 4020
ggagctggcg ctcggtgagg gcgggctgcc gaagctgccc gacaccgtgg catccgagat 4080
catcgtgccc agcctgatcg atctactgag cgaggtgctg cagcgccacc gcccggctgt 4140
cggtggcaag gccgggcagg agcaggagtt tccgagtccg ccgggcgcga acgccgagct 4200
gtggcgccag ttgagcgacc ggatcgcccg ggggcaggcc atcccgaaga ccgcatggca 4260
cacccttgag gcgttccatc cgctgccgaa gcagttcgcg gcaacggtga cgcccgccgc 4320
ggacggtgcg gtgacgtgtt ctccgtcgtc cacagcggcc tggctgtcgg ctgtggggac 4380
ggacgccgga gcatcgaccc gcgcctatct cgatgaagcg cagagccgct acggcggagc 4440
gatcccgatg ggaagctcca tgccgtactt cgaggtgctc tgggtgctca atctggtgct 4500
caagtacttc ccggacgtgc cgatccccag ggagatcatc gaagagattg ccgccgggtt 4560
cagcgattcg ggcatcggcg gcgggccggg tctgccgccc gacggagacg acacggccta 4620
cgccaatctc gccggcgaca aactcggcgc ccccactcac ccggaaatcc tgatgaagtt 4680
ctgggccgag gaccacttcg tttcgtatcc gggggagcaa acaccctcgg agaccgtgaa 4740
cgcgcacgcc ctcgagtacc tcaatcatct caggatgcgc cgtggcatca cggaattcgg 4800
cgccgtcgag gacgcatgtg ccgagtgggt gatctcccag cagaccgagg acggctgctg 4860
gtacgacaaa tggaacgtct cgccgtacta ctccacggcg gcatgtgtcg aagccctgct 4920
cgacgcccgg aagcaggatg aaccgcagct ggattcgctg cgtcgcgcca gggaatggct 4980
gcttcgacac cagacggatt cgggcggctg gggaatggcg gagccgtcac ccgaggaaac 5040
ggcctacgcg gtgctggcgc tcgacctgtt cgcgagccgt ggcggcgagg gcgccgagga 5100
gtgtgcggcg gcgatatcca gggccaagga attcttcacg gacgagtcca gggagaatcc 5160
cccgctgtgg atgggcaagg acctgtacac gcctttccgg atcgtcgacg tgacggtgat 5220
gtgcggccgt gccgtcgtgg gcaggtactg atgcccgacg cgatcgagtt cgagcacgaa 5280
ggccggcgga acccgaattc ggcggaggcc gaatcggcct acagctccat cattgctgcg 5340
ctcgacctcc aggaatccga ctacgccgtg atttccgggc actcgaggat cgtgggggcc 5400
gcggcgctgg tctatcccga tgcggatgcc gaaaccttgc tcgcggcttc gctgtggacg 5460
gcctgcctca tcgtcaacga cgaccggtgg gactacgtcc aggaggacgg cgggcggctg 5520
gctccgggcg agtggttcga cggggtcacc gaggtcgtgg acacctggcg aactgccgga 5580
ccccgcctgc cggacccctt cttcgagctg gtgcggacga cgatgtcccg gctcgacgca 5640
gcgctcggcg cggaagcagc ggacgagatc ggccacgaga tcaagcgcgc catcacggcg 5700
atgaagtggg aaggggtatg gaacgaatac accaagaaga cgtccttggc gacgtatctg 5760
agcttccgcc gcggctactg cacgatggac gtccaggtcg ttctggacaa gtggatcaac 5820
ggcggccgca gtttcgcagc gctgcgtgac gaccccgtcc ggcgagcgat cgacgatgtg 5880
gtggtgcggt tcggctgtct gtcgaacgac tactactcgt ggggccggga gaagaaggcg 5940
gtcgacaagt cgaatgcggt gcggatcctg atggaccacg ccggctacga cgagagcacc 6000
gcgctggccc acgttcgcga tgactgcgtg caggcgatca ccgacctgga ctgcatcgag 6060
gaatccatca agcgaagcgg ccatctcggc agccatgcac aggagttgct cgactacctc 6120
gcatgccatc gaccgctgat ctacgcagcg gcgacctggc cgacggagac gaaccgctac 6180
cgctgagcag caaatcgcgc catcgacccc ccacaaagag ggccgtccct cctcgccctc 6240
ggtgtacgga tgaagggaaa cctaccagcg atgagcactg ccacctcttc cagcgtcacc 6300
ggctccgtca ccacccccag aaccgctacg actccgggca ggcgtcccgg cctggctccg 6360
ggtggcgtcc cggtgctcgg gcatctgccg atgatcctgc ggtcccgttt cgagttcatc 6420
gaaacggtgc gcaacgcagg cccggtgacg cgggtcaagc tgggcccgaa gaccgcgtac 6480
ttcgtcaacg actacgagct gctcgcccag atcctggtga gtgacgcgga caagttcgtg 6540
cgcggcatcc acttcaagaa gatgcggaac atggtcggga acggcgtggt cacgacctcc 6600
ggtgacctgc accgacggca acggcggatc atgctcccgt cgttcagcca gcgccggctg 6660
gccatgcatc tccccgtgat gcggaagatc atgtccgaat tcgtcgcctc ggtgcccgaa 6720
cggcggccct atgacctgat ggggccggtc atgggagtcg gctgcgacat cgtgacctcg 6780
accatgctcg gcgagaagac cccgccggag gtcctgcgac tcgtgcgcga ggccgtcccg 6840
gtcttcgtcg agaacgccgc gatccaggcc gtcgatgtga ccggcatcta caagcacctg 6900
ccgacgaagt cgaaccggga cttcgaaagg ctgctcaacg ccttcaacga gtacatgtac 6960
tcggtcatcg acgacaagtt ccgcaacgga gccggtgagg aagccggcct cctcgacatg 7020
ctgatcaacg cgaccgaccc ggagaccggc gagaagttcg accggaccga ggtccgtgac 7080
caggccgcga cgatcctgct ggcgtcgacg gagaccacgg cgaacaccat cagctgggcc 7140
tgctacgaac tggcccggca cccgcggatc ttcgccgaat gccgggcgga gatcgacgcg 7200
ctggtcaagg atcgtgactg gctggacatc gagatcggtc ggcacgatct gccggcgctc 7260
aagcgggtgc tgttcgaggc gctgcgcatg tacccgtcct cgtacctcct ctcgcggcag 7320
gcgtcggtgg acacgacgct gggcggctac gccattccga aggatgccgc gatcctgtac 7380
tcgcactacg ggcagcagcg ggacgaacgg aacttcccgc acggcgacga gttcgacccc 7440
gaccgctggc tggacaagga cggcgccgag gtcacggcat ccgcgttcat gccgttcggg 7500
ttcggcgcgt accgctgcct cggcgagagc gtggcggtgc tggaggcgac ctactgcctg 7560
gccatgatgg tccaccagtg ggacttcgcg ctcagcgact actcggagcc gaagatgaac 7620
gcgacgatca cgctctcccc gaaggacctg gagttcctgt tcaccaagcg gacggagagc 7680
ggagcgcacg atgagtgacc tcgaggtgcg ggtggaccgc gacctgtgcg tgggctccgg 7740
gcagtgcctg atctctgccg ccgactactt cgggcaggac atcgaggggt acgtggaact 7800
gctcccggac gccccgacgg ccgacctcgc cacgaacgaa gaggtgcagg aagcggtcga 7860
gaagtgcccc tccggggcgt tgtcctggca tcgcccggac taggacgtgc ggcgaaagcg 7920
catcctggtc gtgagtgatc acccgccgca agacgtgggg acctgacgaa cgaccagtgg 7980
gcccggcttg aaccgctgct gccgccgggc acaaagccgg gccgtccacc ggtgtggacc 8040
cggcggcagc tgatcgacgg cacacggtgc ggtcgagcag ggacaagagc cactgtcgct 8100
gctcgccgct gctggtcagc ggcatgacag cccgcagttc cagccggtcc cggagggcat 8160
ccgggcgccc cgcaccggtc gaggccggcc gcggacccgg ccggacaagg tccgcgccga 8220
caaggcgtac ggctcccgcg cgaaccgcac ctgcctgcgc agacgcggca ggggcacgcc 8280
acgcggtgga gcgcgggatc aacaggctca ggcgccaccg ggccgtggcg gctcgatccg 8340
agaggctcgc cgtccgttac gaggcgaccg tgctggtcgc agccctcaac gagtggctgt 8400
gaccagcact ttcgccgcgc cccagcgcga cctggatccg aggtccggcc ggcccgagct 8460
cgatgccggg ccgcccgggc cggatcc                                     8487



<210> 601
<211> 2474
<212> DNA
<213> Lactuca sativa

<220> 
<223> copalyldiphosphate synthase No. 1

<400> 601
taaaggttat aaatcgttac ctcttcggtg caaaagctgt gtttaaaagt acaaaatcct 60
ataatccaat cgccatgaag acaatgatct cctctccgat tccagccttc cacccccggt 120
tctctccggc ggcaggttct cgtcgtcttt ctcccatcct tccatccagt ggcagtgtag 180
tccttactgg atcgaaaacc caatgcaaag ccgtatcaaa gtctcctaca caagaatact 240
ttgatgtact tcaaaaaaat ggtttaccat ttataaactg gcagaatgac gtcgtggagg 300
atgagttgga taaagaaaag aagattttgt atcctaatga tgagatcaaa gggtttgtcg 360
agaggatcaa agtgatgttg ggatcgatgg atgagggaga gataactgta tcagcttatg 420
acacagcttg ggttgcactc gttcaagata ttgacggaaa tggtcgcccc gagtttccgt 480
caagtttaga atggatcgtg aaaaatcaac tatctgacgg atcatggggc gaccatttga 540
tcttttcggc tcatgaccgg atcataaata cgttggcatg tgttatcgcc ctaacttctt 600
ggaacgttca tcccggtaaa tgccaaaaag gactgaaatt tctgaatgac aatataagca 660
aacttgaaga ggaaaatcca gaacacatgc cgatcggttt tgaagtagct ttcccttcgc 720
tcattgacat tgcaaggaaa ctagacattc aagtccccga ggattctccc gccttgaaag 780
aaatctatgc aagacgaaac ctgaagctca caaagatacc gaagagctta atgcacaaag 840
tgccaacaac tttacttcat agcttggaag gaatgccaga tttggagtgg gaaaagcttc 900
taaaattgca gtgcaaagat gggtcatttc tgttttctcc atcatctact gcttttgcac 960
tcatgcaaac aaaagatcaa aagtgtctgc agtatcttac agatgctgtc accaaattca 1020
atggtggagt tccgaacgtg tacccagtgg atctttttga gcatatttgg gtcgttgatc 1080
gccttcaacg acttgggatt tcgcgttatt tcgattccga gataaaggat tgcgttgact 1140
atatataccg gtattggacg aaggacggaa tttgttgggc gaagaactct aacgtacaag 1200
atattgatga caccgcgatg ggatttaggg ttttaagaat gcacggctat aaagttacta 1260
cagatgtatt tcgacaattc gagaaagatg gtaaatttgt gtgcttccct gggcaaacaa 1320
cacaagcggt taccggaatg ttcaatttat ttagggcttc gcaggtgctc ttccccgatg 1380
agaaaattct cgaagatgcc aagaaatttt cgtataacta tttgaaggag aaacaatcga 1440
caaacgagct tcttgataaa tggatcatcg ccaaagactt gccaggcgag gttgaatacg 1500
cattagatgt cccatggtat gcgagcttac ctcgactcga aacaagattt tacttggagc 1560
aatacggagg tgaagacgac gtttggattg ggaaaaccct atacaggatg ggtaatgtga 1620
gcaataatac gtatcttgag atggctaaat tggattacaa taactgtcta gcaatacatc 1680
acctcgaatg gaacactatg caacaatggt atgtggattt tggtatggaa cggtttggga 1740
cgagtgacat cacgagcctt ttggtgtcat actaccttgc agcggctagt gtattcgagc 1800
cagaaagatc caaggaacgg atagcatggg ctaaaactac tacattagtc gacaccatct 1860
cctcgttttt ccactcactc aaaatctcca atgagcatag gagagagttt gtagaggagt 1920
tcagaaacat atccaattca attcatcatg ccaaatacgg gaagccatgg catggattga 1980
tggttgcact gaaaggaacc ctacacgaga tcgctttgga tgttcttatg actcatcgta 2040
gagacatcca tccacagctt caccatgcct gggagatgtg gttgatgagg tggcaacaag 2100
gcgtagacgc aacggaagga caagcggaac tgatagtaca aacgataaac atgacggccg 2160
gccgatgggt gtccaacgaa ctcttagccc atccgcaata cagactcctc tcatccgtca 2220
ttaataacat ctgtcacgaa atataccaca atcgaacctg catggaagtc aacagtacaa 2280
ctatcagcac gtcgatagat tccaaaatgc aagaactcgt gcaactcgtg ctcagcgact 2340
cactggatga tcttgatcag gatttaaagc agacgttcct caccgttgca aaaaccttct 2400
actacaaggc gtactgcgat cctgagacaa ttaatgttca tatttccaaa gtaatgttcg 2460
aaacgataat ttga                                                   2474

<210> 602
<211> 1832
<212> DNA
<213> Lactuca sativa

<220> 
<223> germacrene A synthase LTC1

<400> 602
tctcatcgag cttttctata ccctttcaac ttcaagaaat ggcagcagtt gaagccaatg 60
gtacccttca agcaaacacc aaaaccacca cagagcctgt gcgtcctttg gccaatttcc 120
ctccttctgt atggggtgat cgtttcttgt cattctctct tgacaatacg gaattggaag 180
gatatgcaaa agccatggag gagcccaaag aagaagtgag aagattgatc gtagatccaa 240
caatggattc aaataagaaa ctaagtttga tttattctgt acatcgactt ggtttgacat 300
atcttttctt gcaagagata gaagcacagc ttgacaatat tttcaaagcg tttaaattgc 360
aagattatga tgaagttgat ctatacacaa cttctattaa ctttcaagtt ttccgacacc 420
ttggtcacaa actgccttgt gatgtgttta acaaattcaa ggacagcagc tcgggtacat 480
tcaaggaatc cattaccaac gatgtgaagg gtatgctagg tctatatgaa tgtgcgcaat 540
tgagattacg aggtgaatcg attctagatg aagcctcagc attcactgta actcagctaa 600
agagtgtagt aaacactctt gaaggaaaac ttgcacagca ggtattacaa tcattgaaga 660
gaccattcca tcaagggatg ccaatggttg aggcaaggtt ttatttctcc aactatgatg 720
aagaatgttc cacacatgag tcgctagtaa agcttgcaaa gctgcatttc aactatttgc 780
agctacaaca aaaggaagaa cttcgcattg tctcaaagtg gtggaaggat atgaggttcc 840
aggaaactac tccatatata agggatagag taccagagat ttacttatgg attttgggat 900
tgtactttga gcctcgttat tccttggcac gaatcatcgc cacaaaaatt acattgtttc 960
ttgtggtgct agatgacaca tacgatgcat atgctaccat cgaagagatt cgacttctaa 1020
cagatgccat aaataggtgg gacattagtg ctattgagca aattccggaa tacattcgac 1080
cattctacaa aattctccta gacgagtatg cggaacttga gaaacaacta gctaaagaag 1140
gaagagcaaa aagcgtcatt gctttaaaag aagcgttcca agacattgct agaggctacc 1200
ttgaagaggc cgagtggacg aacagtggtt atgttgcatc atttccagag tatatgaaga 1260
acgggttagt tacatctgcc tacaatgtta tttcgaaatc tgccttagtg ggtatgggtg 1320
agatggttag tgaagatgct ttggcctggt atgagagtca tccaaagact ttgcaagctt 1380
cagagttaat ttcaagactc caagatgatg tcatgactta ccagtttgag cgagaaaggg 1440
gtcaatcagc cactggtgtt gactcatata tcaagacgta tggcgtgtca gaaaaggaag 1500
ctattgatga gctgaataaa atgattgaaa atgcatggaa ggatataaac gagggatgcc 1560
ttaagccaag agaagtctct atggatttgc ttgccccaat tcttaatctt gcaagaatga 1620
tagatgtggt atacaggtac gacgatgggt ttacttttcc gggaaagacc atgaaagagt 1680
atattaccct tttgtttgtt ggttcgtcac ctatgtaata aattaataat tgttgtttca 1740
tatttttgtt gtttcatatg ttcattacaa ttttcccaat gatgaataat aaatatattg 1800
tggtcgggta tatcaattta aaaaaaaaaa aa                               1832

<210> 603
<211> 1830
<212> DNA
<213> Lactuca sativa

<220> 
<223> germacrene A synthase LTC2

<400> 603
gctcaaccaa tcaccattcc acaaaacctg aagcttcaca aatcacaaac cccaattcaa 60
tttcaagaaa tggcagcagt tgacactaat gccaccatcc aagaaaagac caccgcagag 120
ccggtgcgtc ctttagccaa cttccctcct tcggtatggg gtgatcgctt cctatcattc 180
actcttgaca attcggaact cgaaggatat gcaaaagcca tggaagcccc aaaagaagaa 240
ttgagaagat tgattgtaga tcaaacaatg gattcaaata agaaactaag tttgatttat 300
tccgtccacc gtcttggttt gacatatctg ttcttgcaag agattgaagc ccagctagac 360
aaaattttca aagagttcaa cttgcaaaat tatgatgaag ttgatcttta cacaacttct 420
atcaactttc aagttttccg acaccttggt tataaactac cttgtgatgt gtttaacaaa 480
ttcaaagaca atacctccgg cgctttcaag gaagatattt ctacggatgt gaagggcatg 540
ctaggcttat acgaatcttc acaactaaga acaagaggag aatcgatact agatgaggct 600
tcatcgttca ctgaaactaa actcaagagt gtagtaaaca atcttgaagg aaatcttgca 660
caacaggtgt tacaatcatt gaggagacca tttcatcaag ggatgccaat ggtggaggca 720
aggctatatt tctccaacta tagtgaagag tgtgccacac atgagtgttt attaaagctt 780
gcaaagctgc atttcagcta tttggagcta cagcaaaagg aagaacttcg cattgtctca 840
aagtggtgga aagatatgag attccaggaa actacacctt atataaggga tagagtacca 900
gagatttact tatggatttt gggattgtac tttgagcctc gttactcctt ggcacgaatc 960
atcgccacaa aaattacatt gtttcttgtg gtgctagatg atacatatga cgcttacgct 1020
accattgaag aaattcgact tttaactgat gccataaata ggtgggacat gagtgctatg 1080
gagcaaattc cggaatacat tagaccattc tacaaaattc tcctagatga gtatgctgag 1140
cttgagaaac aactagctat agaaggaaga gcaaagagcg ttattgcttc aaaagaagcg 1200
ttccaagaca ttgctagagg ctaccttgaa gaagccgagt ggacaaacag tggatatgtg 1260
gcatcatttc ctgagtacat gaagaatggg ttaatcactt cagcctacaa tgttatttcg 1320
aaatctgctt tagtgggtat gggcgacata gttagtgaaa atgcattggc atggtacgaa 1380
agtcatccaa agactctaca agcttccgag ttaatctcaa gactccaaga tgatgtcatg 1440
acttaccagt ttgagcgtga aagaggacaa tcagccactg gagttgatgc gtatatcaag 1500
acatacggcg tgtcagagaa ggaagctatt gatgagctaa agataatgat tgaaaatgca 1560
tggaaagata taaacgaggg atgtctcaag ccaagagaag tctcgatgga tttgctcgcg 1620
ccaattctta accttgcaag aatgatagat gttgtgtatc gatatgatga tgggttcacc 1680
tttcctggaa aaaccatgaa agagtatatt actcttttat ttgttggttc tgtatccatg 1740
taatgataca caatcattgt tgtttcatat gtttaatgtc ataaaagaaa tattaatcaa 1800
taataattat tgcaagtggc ctcatgaaaa                                  1830

<210> 604
<211> 1617
<212> DNA
<213> Lavandula angusivolia

<220> 
<223> (E)-alpha-bergamotene synthase

<400> 604
atggaggcga gaaggtcggg gaatttcgag tccagcatct gggacgacga ttacattcag 60
tccctaacga gttcatatac gggtaaaatg tacgtagata aatctgagaa gctgaaaatt 120
gaggtgaaga tgatgatgga cgaagcaaca gatgagttgg agcaactcga gcttatcaac 180
gatctgcaaa ggcttggtat atcttaccac ttcaaagatg gcatagctaa gatgttgaac 240
aacatttata agtcagatag caaatacatg gaaaaggact tgcacctcac agctctcaaa 300
tttagacttc ttagacaaca tggatatcgt gttcctcaag atgtttttag tagtttcatg 360
gatgatgaag gaaatttcga ggcctgggtg gttgaagacg tgtcagttct tgtatctctg 420
tatgaagctt cgcacatatc agtggaaggg gagagcatat tggatatggc gaaagatttc 480
tcatcgcatc atcttactga aatggtggag cagattggtg aggcgtgttt agccgagcaa 540
gtgaagcgta cgttggagct tccactacac tggagagttg ggagacttga agccagatgg 600
ttcgtacaag cctacgagac tagacccaac tcaaacccca ctctggtgga gctagccaaa 660
ctagatttca acatggtaca agccaaatac caggatgagc ttaaacgctg ttcaaggtgg 720
tatgaagaaa ctggcctacc cgaaaagatg agttttgcca gacaccgatt ggcagagtgt 780
tttttgtggt ctctgggatt tataccagat cctcatcatg ggtattcgag ggagattatg 840
accaagattg cagtgctaat tacgataaca gatgacatat acgacattta tggagcgtta 900
gaagaacttc aagagttcac agaggcattc gagagatggg atatcaattc attggatctc 960
cttccagaat acatgcaaat ctgtttctta gcaatcttca actctgcaaa tgaattgggt 1020
tatcaaattc tgagggacca aggcctcaat attatcccaa atctgaagag atcgtgggca 1080
gaattgagta gagcttacta cttagaagca agatggtttc acaacggatt tgtcccaact 1140
acagatcagt atctgaatac tgcttggatt tccatttcgg gtcctctact tctttcctat 1200
ggctacctca ccaccacgaa tcccataaac aacaaggaac tgaagagcct agaaaaacat 1260
cctagtatca tccgttggcc atccatggtt cttcgacttg cagatgattt gggaacttca 1320
tcagaagaaa tcaaaagagg ggatgtctcg aaatcaatcc aatgctacat gaatgaaaca 1380
ggatgctgcg agggggatgc ccgacatcac gtaaagagtt tgattgaggt agcattgaag 1440
cgaatgaacg atgagatatt gatggagaag cccttcaaga gtttcgacac caacgccatg 1500
aatcttgcac gaatatctct ctgcttctat caatatggtg atggtttcgg gaagccccac 1560
tctgatacca tcaagaactt ggtgtcactc attgttctac ccttccatat gccatga    1617

<210> 605
<211> 2024
<212> DNA
<213> Lycopersicon esculentum

<220> 
<223> germacrene C synthase

<400> 605
aaaaaaagcc aaaccttaga acaaacaagc aatggctgct tcttctgctg ataagtgtcg 60
ccccttggct aattttcacc catctgtttg gggatatcat ttcctttctt atactcatga 120
aattactaat caagaaaaag ttgaagttga tgagtacaaa gagacaatta gaaaaatgct 180
ggtggaaact tgcgacaata gcactcaaaa gcttgtgttg atagacgcga tgcaacgatt 240
gggagtggct tatcatttcg ataatgaaat tgaaacatcc attcaaaaca tttttgatgc 300
atcgtccaaa cagaatgata atgacaacaa cctttacgtt gtgtctcttc gttttcgact 360
tgtgaggcaa caaggccatt acatgtcttc agatgtgttc aagcaattca ccaaccaaga 420
tgggaaattc aaggaaacac ttactaatga tgtccaagga ttattgagtt tgtatgaagc 480
atcacatctg agagtgcgta atgaggagat tcttgaagaa gctcttacat ttaccaccac 540
tcatctcgag tctattgtct ccaacttgag caataataat aactctctta aggttgaagt 600
tggtgaagcc ttaactcagc ctattcgcat gactttacca aggatgggag ctagaaaata 660
catatccatt tacgaaaaca atgatgcaca ccaccatttg cttttgaaat ttgctaaatt 720
ggattttaac atgctgcaaa agtttcacca aagagagctt agtgatctta caaggtggtg 780
gaaagatttg gattttgcaa ataaatatcc atatgcaaga gacaggttgg ttgagtgtta 840
cttctggata ttaggagtgt attttgagcc aaaatatagt cgtgcgagaa aaatgatgac 900
aaaagtactc aacctgacct ccattattga cgacactttt gatgcttatg caacctttga 960
cgaacttgtg actttcaatg atgcaatcca gagatgggat gctaatgcaa ttgattcaat 1020
acaaccatat atgagacctg cttatcaagc tcttctagac atttacagtg aaatggaaca 1080
agtgttgtcc aaagaaggta aactggaccg tgtatactat gcaaaaaatg agatgaaaaa 1140
gttggtgaga gcctatttta aggaaaccca atggttgaat gattgtgacc atattccaaa 1200
atatgaggaa caagtggaga atgcaatcgt aagtgctggc tatatgatga tatcaacaac 1260
ttgcttggtc ggtatagaag aatttatatc ccacgagact tttgaatggt tgatgaatga 1320
gtctgtgatt gttcgagctt ccgcattgat tgccagagca atgaacgata ttgttggaca 1380
tgaagatgaa caagaaagag gacatgtagc ttcacttatt gaatgttaca tgaaagatta 1440
tggagcttca aagcaagaga cttacattaa gttcctgaaa gaggtcacca atgcatggaa 1500
ggacataaac aaacaattct cccgtccaac tgaagtacca atgtttgtcc ttgaacgagt 1560
tctaaatttg acacgtgtgg ctgacacgtt atataaggag aaagatacat attcaaccgc 1620
caaaggaaaa cttaaaaaca tgattaatcc aatactaatt gaatctgtca aaatataaat 1680
ataatgctga aattgcacct tcatcatcca actattcaca gcaaaataag gcatataata 1740
aattgaagac tcacaacata tgagttgtta attcctggga tgtttgaaat aaacaataat 1800
tgtttttatt taatttgcta agccaaagtg aaatatacaa cacttgagtt gtattaaatc 1860
atgttttatc tcatttccag cttgtgagtt tggattatta tattgttaat tatcatcact 1920
ttataatgta ctgtaatcgt attgtatttg tattgtagtg ttgtcataat aaaatttgaa 1980
taaaatatat ttttgtttca attccaaaaa aaaaaaaaaa aaaa                  2024

<210> 606
<211> 2018
<212> DNA
<213> Lycopersicon esculentum

<220> 
<223> delta-elemene synthase

<400> 606
aaaagcaaac cttagaacaa acaagcaatg gctgcttctt ctgctgataa gtgtcgcccc 60
ttggctaatt ttcacccatc tgtttgggga tatcatttcc tttcttatac tcatgaaatt 120
actaatcaag aaaaagttga agttgatgag tacaaagaga caattagaaa aatgctggtg 180
gaaacttgcg acaatagcac tcaaaagctt gtgttgatag acgcgatgca acgattggga 240
gtggcttatc atttcgataa tgaaattgaa acatccattc aaaacatttt tgatgcatcg 300
tccaaacaga atgataatga caacaacctt tacgttgtgt ctcttcgttt tcgacttgtg 360
aggcaacaag gccattacat gtcttcagat gtgttcaagc aattcaccaa ccaagatggg 420
aaattcaagg aaacacttac taatgatgtc caaggattat tgagtttgta tgaagcatca 480
catctgagag tgcgtaatga ggagattctt gaagaagctc ttacatttac caccactcat 540
ctcgagtcta ttgtctccaa cttgagcaat aataataact ctcttaaggt tgaagttggt 600
gaagccttaa ctcagcctat tcgcatgact ttaccaagga tgggagctag aaaatacata 660
tccatttacg aaaacaatga tgcacaccac catttgcttt tgaaatttgc taaattggat 720
tttaacatgc tgcaaaagtt tcaccaaaga gagcttagtg atcttacaag gtggtggaaa 780
gatttggatt ttgcaaataa atatccatat gcaagagaca ggttggttga gtgttacttc 840
tggatattag gagtgtattt tgagccaaaa tatagtcgtg cgagaaaaat gatgacaaaa 900
gtactcaacc tgacctccat tattgacgac acttttgatg cttatgcaac ctttgacgaa 960
cttgtgactt tcaatgatgc aatccagaga tgggatgcta atgcaattga ttcaatacaa 1020
ccatatatga gacctgctta tcaagctctt ctagacattt acagtgaaat ggaacaagtg 1080
ttgtccaaag aaggtaaact ggaccgtgta tactatgcaa aaaatgagat gaaaaagttg 1140
gtgagagcct attttaagga aacccaatgg ttgaatgatt gtgaccatat tccaaaatat 1200
gaggaacaag tggagaatgc aatcgtaagt gctggctata tgatgatatc aacaacttgc 1260
ttggtcggta tagaagaatt tatatcccac gagacttttg aatggttgat gaatgagtct 1320
gtgattgttc gagcttccgc attgattgcc agagcaatga acgatattgt tggacatgaa 1380
gatgaacaag aaagaggaca tgtagcttca cttattgaat gttacatgaa agattatgga 1440
gcttcaaagc aagagactta cattaagttc ctgaaagagg tcaccaatgc atggaaggac 1500
ataaacaaac aattcttccg tccaactgaa gtaccaatgt ttgtccttga acgagttcta 1560
aatttgacac gtgtggctga cacgttatat aaagagaaag atacatatac aaacgccaaa 1620
ggaaaactta aaaacatgat taattcaata ctaattgaat ctgtcaaaat ataaatataa 1680
tgctgaaatt gcaccttcat cattcaacta ttcacagcaa aataaggcat ataataaatt 1740
gaagactcac aacatatgag ttgttaattc ctgggatgtt tgaaataaac aataattgtt 1800
tttatttaat ttgctaagca aaagtgaaat atacaacact tgagttgtat taaatcatgt 1860
tttatctcat ttccagcttg tgagtttgga ttattatatt gttaattatc atcactttat 1920
aatgtactgt aatcgtattg tatttgtatt gtagtgttgt cataataaaa tttgaataaa 1980
atatattttt gtttcaattc aaaaaaaaaa aaaaaaaa                         2018

<210> 607
<211> 2003
<212> DNA
<213> Lycopersicon esculentum

<220> 
<223> delta-elemene synthase

<400> 607
ctcgtgccga attcggcacg agcttctgct gataagtgtc gccccttggc taattttcac 60
ccatctgttt ggggatatca tttcctttct tatactcatg aaattactaa tcaagaaaaa 120
gttgaagttg atgagtacaa agagacaatt agaaaaatgc tggtggaaac ttgcgacaat 180
agcactcaaa agcttgtgtt gatagacgcg atgcaacgat tgggagtggc ttatcatttc 240
gataatgaaa ttgaaacatc cattcaaaac atttttgatg catcgtccaa acagaatgat 300
aatgacaaca acctttacgt tgtgtctctt cgttttcgac ttgtgaggca acaaggccat 360
tacatgtctt cagatgtgtt caagcaattc accaaccaag atgggaaatt caaggaaaca 420
cttactaatg atgtccaagg attattgagt ttgtatgaag catcacatct gagagtgcgt 480
aatgaggaga ttcttgaaga agctcttaca tttaccacca ctcatctcga gtctattgtc 540
tccaacttga gcaataataa taactctctt aaggttgaag ttggtgaagc cttaactcag 600
cctattcgca tgactttacc aaggatggga gctagaaaat acatatccat ttacgaaaac 660
aatgatgcac accaccattt gcttttgaaa tttgctaaat tggattttaa catgctgcaa 720
aagtttcacc aaagagagct tagtgatctt acaaggtggt ggaaagattt ggattttgca 780
aataaatatc catatgcaag agacaggttg gttgagtgtt acttctggat attaggagtg 840
tattttgagc caaaatatag tcgtgcgaga aaaatgatga caaaagtact caacctgacc 900
tccattattg acgacacttt tgatgcttat gcaacctttg acgaacttgt gactttcaat 960
gatgcaatcc agagatggga tgctaatgca attgattcaa tacaaccata tatgagacct 1020
gcttatcaag ctcttctaga catttacagt gaaatggaac aagtgttgtc caaagaaggt 1080
aaactggacc gtgtatacta tgcaaaaaat gagatgaaaa agttggtgag agcctatttt 1140
aaggaaaccc aatggttgaa tgattgtgac catattccaa aatatgagga acaagtggag 1200
aatgcaatcg taagtgctgg ctatatgatg atatcaacaa cttgcttggt cggtatagaa 1260
gaatttatat cccacgagac ttttgaatgg ttgatgaatg agtctgtgat tgttcgagct 1320
tccgcattga ttgccagagc aatgaacgat attgttggac atgaagatga acaagaaaga 1380
ggacatgtag cttcacttat tgaatgttac atgaaagatt atggagcttc aaagcaagag 1440
acttacatta agttcctgaa agaggtcacc aatgcatgga aggacataaa caaacaattc 1500
ttccgtccaa ctgaagtacc aatgtttgtc cttgaacgag ttctaaattt gacacgtgtg 1560
gctgacacgt tatataaaga gaaagataca tatacaaacg ccaaaggaaa acttaaaaac 1620
atgattaatt caatactaat tgaatctgtc aaaatataaa tataatgctg aaattgcacc 1680
ttcatcattc aactattcac agcaaaataa ggcatataat aaattgaaga ctcacaacat 1740
atgagttgtt aattcctggg atgtttgaaa taaacaataa ttgtttttat ttaatttgct 1800
aagccaaagt gaaatataca acacttgagt tgtattaaat catgttttat ctcatttcca 1860
gcttgtgagt ttggattatt atattgttaa ttatcatcac tttataatgt actgtaatcg 1920
tattgtattt gtattgtagt gttgtcataa taaaatttga ataaaatata tttttgtttc 1980
aattcaaaaa aaaaaaaaaa aaa                                         2003

<210> 608
<211> 2030
<212> DNA
<213> Lycopersicon hirsutum

<220> 
<223> germacrene B synthase

<220> 
<221> variation      
<222> 1721, 1723, 1773, 1832, 1850, 1859, 1880, 1882, 1884, 1901,
1904, 1908, 1913, 1929, 1958, 1959, 1978, 1989, 1997, 2004,
2008
<223> n = a or g or c or t

<400> 608
aaaaagagca aaccttagaa caaacaagca atggctgctt cttctgctaa taagtctcgt 60
cctttggcta attttcaccc aactgtttgg ggatatcatt tcctttctta tactcatgaa 120
attactaacc aagaaaaagt tgaagttgat gagtacaaag agacaattag aaaaatgttg 180
gtggaagctc ctgaaggtag tgaacaaaaa cttgtgttga tagacgcgat gcaacgattg 240
ggagtggcat atcatttcca taatgaaatt gaaacatcca ttcaaaacat ttttgatgcg 300
cccaaacaga acaacaacct tcacattgtt tctcttcgtt ttcgacttgt gaggcaacaa 360
ggacattaca tgtcttcaga tgtgttcaag caattcacca accaagatgg gaaattcaag 420
gaaacgctta ctaatgatgt ccaaggatta ttaagtttgt atgaagcatc atatctgaga 480
gtgcgtgatg aggagattct tgaagaagct cttgccttta ccactactca tctcaaatct 540
attgtctcaa ccatgagcaa taataataac tctcttaagg ttgaagttag tgaagcctta 600
actcagccta ttcgcatgac tttaccaagg atggaagcaa ggagatacat atccatttac 660
gaaaacaatg atgcacacaa ccatttgctt ttgaaatttg ctaaattgga tttcaacatg 720
ctgcagaagt tgcaccaaag agagcttagt gaccttacaa ggtggtggaa agatttggat 780
tttgcaaata aatatccata tgcaagagac aggttggttg agtgttactt ctggatatta 840
ggagtgtatt ttgagccaaa gtatagtcgt gcgagaaaaa tgatgacaaa agtactcaag 900
atgacctcca ttattgacga cacttttgat gcttatgcaa cctttgacga actagaacct 960
ttcaatgatg caatccagag atgggatgct aatgcaatcg attcaatacc accatatatg 1020
agacctgctt atcaagcttt tctagacatt tacagcgaaa tggaacaagt gttgtccaaa 1080
aaaggtaaac tggaccgcgt atactatgca aaaaatgaga tgaaaaagtt ggtgagagcc 1140
tattttaagg aaacccagtg gttgaatgat tgtgaccata ttccaaaata tgaggaacac 1200
atggagaatt cactcgtaag cggtggttat atgatgatac caacaacttg cttggtcggt 1260
atggaagaat ttatatccat agagactttt gaatggttaa tgaatgatcc tttgatagtt 1320
cgagcttcct cattgatagc cagagcaatg aacgatattg ttggacatga agttgaacaa 1380
gaaagaggac atgtagcttc acttattgaa tgttacatga aagattatgg agcttcaaag 1440
caagaggcat acgccaaatt caagaaagat gtcaccaatg catggaagga cataaacaaa 1500
gaattcttcc gtccaactga agtaccaatg tttgtccttg aacgagttct aaatttgaca 1560
cgtgcggctg aaccgttata taaagagaaa gatgcataca caaatgccaa aggaaaactt 1620
aaaaacatga ttaattcaat actaattgaa tctgtcaaaa tataaatata atgctgaaat 1680
tgccttccat cgttcaaata ttcagagcaa aaataagggc ntntaataaa ttggaagaac 1740
ctttaattat gctactcaca ccatattgag ttngtaaatt cctggggatg tttgaaataa 1800
acaataattg gttttaatta atttattaag cnaaagtgga aatttccacn cttggagtng 1860
gattaaatca tgtttaattn anttccactt gtangttggg nttntttntt ggnaaatatc 1920
atcacnttnt aatggacctg gaaccgaatg gatttggnnt gggattgggg gccataanaa 1980
aaattgaana aaaaatnttt ttgnttcnaa aaaaaaaaaa aaaaaaaaaa            2030

<210> 609
<211> 2000
<212> DNA
<213> Lycopersicon hirsutum

<220> 
<223> germacrene D synthase

<400> 609
gcacgagaac aaacaagcaa tggctgcttc ttttgctaat aagtgtcgcc ccttggctaa 60
tttccaccca actgtttggg gatatcattt cctttattat aatcctgaaa ttactaacca 120
agaaaaaatt gaagttgatg agtacaaaga gacaattaga aaaatgttgg tggaagctcc 180
tgaaggtagt gaacaaaaac ttgtgttgat agacgcgatg caacgattgg gagtggcata 240
tcatttccat aatgaaattg aaacatccat tcaaaacatt tttgatgctc ccaaacagaa 300
caatgatgac aaccttcaca ttgtttctct tcgttttcga cttgtaaggc aacaaggaca 360
ttacatgtct tcagatgtgt tcaagcaatt caccaaccaa gatgggaaat tcaaggaaac 420
acttactaat gatgtccaag gattattgag tttgtatgaa gcatcacatc tgagagtgcg 480
taatgaggag attcttgaag aagctcttac atttaccacc actcatctcg agtctattgt 540
ctccaacttg agcaataaaa ataactctct taaggttgaa gttagtgaag ccttaagtca 600
gcctattcgc atgactttac caaggattgg agctagaaaa tacatatcca tttacgaaaa 660
caatgacgca cacaaccatt tgcttttgaa atttgctaaa ttggatttta acatgctgca 720
aaagtttcac caaagagagc ttagtgatct tacaaggtgg tggaaagatt tggattttgc 780
aaataaaatt ccatatgcaa gagacagatt ggttgagtgt tacttttgga tattaggagt 840
gtattttgag ccaaaatata gtcgtgcgag aaaaatgatg acaaaagtac tcaagatgac 900
ctccattatt gacgacactt ttgatgctta tgctaacttt gacgaacttg tgcctttcaa 960
tgatgcaatc cagagatggg atgctaatgc aatcgattca ataccgccat atatgagacc 1020
catttatcaa gctcttctag acatttacgg tgaaatggat caagtgttgt ccaaagaagg 1080
caaactggac cgtgtatact atgcaaaata tgagatgaaa aagttggtga gagcctattt 1140
taaggaatcc caatggttga acgatgataa tcatattcca aaatatgagg aacacatgga 1200
gaatgcaatc gtaactgttg gctatatgat gggagcaaca aattgcttgg ttggtatgga 1260
ggaatttata tctaaagaga cttttgaatg gttgatgagt gagcctgtga ttgttcgagc 1320
ttcctcattg atcggcagag caatggacga tattgttgga catgaagttg aacaagagag 1380
aggacatgta gcttcaatta ttgaatgtta catgaaagat tatggagctt caaagcaaga 1440
ggcttacgcc aaattcaaga aggatgtcac caatgcatgg aaggacataa acaaagaatt 1500
cttccgtcca actgaagtac caatgtttgt ccttgaacga gctttaaatt tcacacgtgt 1560
gatagacacg ttgtatcaag aggaagatga atatacaaac gccaaaggca aacttaaaaa 1620
catgattcac tcgatactga ttgaatctgt caaaatataa atataatgat gaaattgcac 1680
cttcatcatt caaatattca gagcaaaata aggcacatac aataaattga agacctttaa 1740
tatgctattc ataatatatg agctgttaat gaaataaaca atagttgttt ttaatttact 1800
tagcaaaagt gtgattggtt tgtctttttc ctgttttcaa aaaatataca acactcagag 1860
ttgtattaaa tcctgtttta tttcatttcc agcttgttgg atgattgtta attatcatca 1920
ctttataatg tattgtattt atattgtatt gttatcgtaa taaaatttga ataaattata 1980
tctttaaaaa agaaaaaaaa                                             2000

<210> 610
<211> 2339
<212> DNA
<213> Magnolia grandiflora

<220> 
<223> beta-cubebene synthase

<400> 610
atggatagtc ccactactca aaggccaaac atggagattg gtcgtgcttt tgtaaattat 60
caccctagta tctggggtga acacttcatt gcagcctctc cagatgtcat ggtatatcga 120
tattcgtgtg ctagttcttt ggcttgtaaa tgtgatagta cagtacacac tttctgaaaa 180
aaaaaaagaa aagtgtagaa ttcttggtgg aatgcatgca cacaaagaaa gagatctgcc 240
acgaattgtt tagcctgttc tgcgagtcag gatagccagc atatgccacc ccttaggatc 300
cgcatccatg tcaatgatct gaactttcct tcttctcaat gaaagttctc ctaacctttt 360
tcttagaatc atctgtttac tgtaattttc ttatcagacc atctcagctt atgctaatcc 420
tgagatgccc aaatgggaaa accagttctc ctctgaaaca tcattacaca tgtttttcaa 480
acaagattta tcctaattga cttttggatt aattaggctt tcttttgttt acacatgcac 540
ttggggttta aatctgaagt aatatcaaaa tgtgttctat gaatattctt tgaagaatta 600
ttttggaact ttttaacaat ctttgttgtt attcatttaa atattgtcta tttcctaggt 660
attctgaaaa tgatgtgctt tatggtttct ccataagcca ttaaaagatg ccaaatttct 720
gttctttttc aaaatgatgt aatatttgcc ttgattttat tttttatttt tttcctctaa 780
acttggtgtt aaagcagagg ttggacgcac ataaaggacg tggtgaagaa ttgaaggaag 840
tagtaaggaa tatgtttagc acggtcaatg atccattgct caaaatgaat ttgattgatg 900
caattcaacg ccttggtgta gcctaccact ttgaaatgga gatagataag gcattgggcc 960
agatgtatga tgaccacatc aatgggaagg acgatggttt tgacctccaa acccttgctc 1020
tccaatttcg actacttagg caacaaggtt ataatgtctc atccggtgtg tttgcaaagt 1080
tcaaggatga tgagggaaat ttcagttcaa tattaagcaa ggacacgcac ggtttattaa 1140
gtttatatga agccgcattc cttggtacac atggggatga tatattggat gaagccatta 1200
ctttcaccac agtgcacctc aaatccacat tgccgcatgt gagtgctccc ctgacaaagc 1260
tagttgaact tgccttagaa ataccacttc acaggcgcat ggagaggcta cagacaaggt 1320
tctatatctc gatttatgag gaagacaggg aacgaaacga tgtgctactg gagttttcaa 1380
agttagagtt tcttaggttg cagtcattgc accagaggga acttagagac atatcattgt 1440
ggtggaaaga aatggacctt ttagcaaagc ttccattcac cagagataga gtgttggaag 1500
gctacttttg gacagtagga gtgtactttg aaccacatta ttcccgagct agaatgataa 1560
tgacaaaaat gatagcattt gcaacagtta tggatgacac ctatgacgta tatggtacat 1620
tggaggagct tgaactactt actgctacga tcgaaaggtg gaatcgtgga gatatggatc 1680
aactgccaga ctacatgaaa gtgattttta ttgcactctt agatggggtc gatgcaactg 1740
aggatgatct aactggggag ggaaaatcat accggatata ctacttaaag gaagcggtta 1800
aggatctggc caaagcctac ttagctgaag caagatgggt cagctcgggg tatgttccaa 1860
cctcagagga gtacatgaag gttgccttaa taagcgctgt ttatcctatg ctttttgttg 1920
catttctcat tggcatggat gaagtcgtga caaaggaggt ccttgagtgg gccatacaca 1980
tgccaacgat gctgaggact tgttctattg tggcccgatt gatggatgac atcccatcaa 2040
acaagcttga gcaagaaagg aagcatgttt catcctcagt agagtgctac atgaaagagc 2100
atggaacctc ctaccatgaa agtattcaaa agcttcggga aatggttgca agtggatgga 2160
aagacatcaa caaggaatgt cttaaaccga ctccagtacc tacggctgtg atcaatgtta 2220
tcctgaattt tacacgtgtg ctcgaaatca tataccaaca tcgagatgga tatactgatg 2280
caagcgttga gaccaaagaa catattgcat cactgtttgt ggaccctatt ccactttaa  2339

<210> 611
<211> 1931
<212> DNA
<213> Malus x domestica

<220> 
<223> (E,E)-alpha-farnesene synthase

<400> 611
ttcttgtatc ccaaacatct cgagcttctt gtacaccaaa ttaggtattc actatggaat 60
tcagagttca cttgcaagct gataatgagc agaaaatttt tcaaaaccag atgaaacccg 120
aacctgaagc ctcttacttg attaatcaaa gacggtctgc aaattacaag ccaaatattt 180
ggaagaacga tttcctagat caatctctta tcagcaaata cgatggagat gagtatcgga 240
agctgtctga gaagttaata gaagaagtta agatttatat atctgctgaa acaatggatt 300
tagtagctaa gttggagctc attgacagcg tccgaaaact aggcctcgcg aacctcttcg 360
aaaaggaaat caaggaagcc ctagacagca ttgcagctat cgaaagcgac aatctcggca 420
caagagacga tctctatggt actgcattac acttcaagat cctcaggcag catggctata 480
aagtttcaca agatatattt ggtagattca tggatgaaaa gggcacatta gagaaccacc 540
atttcgcgca tttaaaagga atgctggaac ttttcgaggc ctcaaacctg ggtttcgaag 600
gtgaagatat tttagatgag gcgaaagctt ccttgacgct agctctcaga gatagtggtc 660
atatttgtta tccagacagt aacctttcca gggacgtagt tcattccctg gagcttccat 720
cacaccgcag agtgcagtgg tttgatgtca aatggcaaat caacgcctat gaaaaagaca 780
tttgtcgcgt caacgccacg ttactcgaat tagcaaagct taatttcaac gtagttcagg 840
cccaactcca aaaaaactta agggaagcat ccaggtggtg ggcaaacctg ggcatcgcag 900
acaacttgaa atttgcaaga gatagactgg ttgaatgttt cgcatgtgct gtgggagtag 960
cattcgagcc tgagcactca tcttttagaa tatgtcttac caaagtcatc aacttagtac 1020
tgatcataga cgacgtctat gatatttatg gctcagagga agagctaaag cacttcacca 1080
atgctgttga taggtgggat tctagggaaa ctgagcagct tccagagtgt atgaagatgt 1140
gtttccaagt actctacaac actacttgtg aaattgctcg tgaaattgag gaggagaatg 1200
gttggaacca agtattacct caattgacca aagtgtgggc agatttttgt aaagcattat 1260
tggtggaggc agagtggtat aataagagcc atataccaac ccttgaagag tacctaagaa 1320
acggatgcat ttcatcatca gtttcagtgc ttttggttca ctcgtttttc tctataactc 1380
atgagggaac caaagagatg gctgattttc ttcacaagaa tgaagatctt ttgtataata 1440
tctctctcat cgttcgcctc aacaatgatt tgggaacttc cgcggctgaa caagagagag 1500
gggattctcc ttcatcaatc gtatgttaca tgagagaagt gaatgcctct gaagaaacag 1560
ctaggaagaa cattaagggc atgatagaca atgcatggaa gaaagtaaat ggaaaatgct 1620
tcacaacaaa ccaagtgcct tttctgtcat cattcatgaa caatgccaca aacatggcac 1680
gtgtggcgca cagcctttac aaagatggag atgggtttgg tgaccaagag aaagggcctc 1740
ggacccacat cctgtcttta ctattccaac ctcttgtaaa ctagtactca tatagtttga 1800
aataaatagc agcaaaagtt tgcggttcag ttcgtcatgg ataaattaat ctttacagtt 1860
tgtaacgttg ttgccaaaga ttatgaataa aaagttgtag tttgtcgttt aaaaaaaaaa 1920
aaaaaaaaaa a                                                      1931

<210> 612
<211> 1662
<212> DNA
<213> Medicago truncatula

<220> 
<223> (-)-cubebol synthase

<400> 612
atgtctactg tagcttactc tgatcatgac gccaagcaaa gaaatcttgc agattatcac 60
ccaagcgttt gggggggttt cttccttcag tatgcttcag aaaccatgga acttgatcag 120
aatcttgcat cacaaattga tacgttgaaa gatgaagtga gaaacatgct tgtctcaaag 180
actgagatgc ccttgacaaa agtcaaattg attgattcaa tatgtcgttt gggtgttggt 240
tatcattttg aaaaagagat tgatgaagtt ttgcaacata ttcacaaaag ttatgttgaa 300
aatggagaaa taacgcttga agacagcctg tgctctcttg ccatgctatt tagggtgttc 360
aggcaacaag gacttcacgt ttcaccaaat gtgttcaaca aatttaaaga caagcaagga 420
aactttaatg aaaatcttag cacggatgtt gaggggatgt taagcttgta tgaagcatca 480
catatgatgg ttcatgaaga tgacatttta gaagaagcat taaatttcac ttcaactcac 540
ctcgagtcca ttgcctctca atcgagccct tcacttgctg cacaaatcga atatacctta 600
aagcaggctc tccacaaaaa cataccaagg ctagaggcac gacactacat ttctatctat 660
gagaaagatc ctacctgtga tgaagttcta ctcactttcg caaaattgga tttcaattta 720
ctccaatccc tacatcaaaa agagtttgga aacatttcca aatggtggaa ggagttggac 780
ttctctacca aactacctta tgcaagagat aggatcgcgg aatgtagctt ttgggttttg 840
actgcatttt ttgaacccca atattctcaa gcaagaaaaa tgatgattaa agtaatcacc 900
ctactttcaa tcattgatga tacatatgat gcatatggaa caattgatga actggaactt 960
tttaccaagg cagttgaaag gtgggatatt agcagcttgg acgaacttcc agactacatg 1020
aaacctatct atagatcatt cttaacaatt tacgaagaaa tagagaaaga aatgagaaaa 1080
gaaggaagga tatataccct tgactactac aaaattgaat tcaaaaagtc agtgcaagca 1140
tttatgacag aggcgagatg gctgaatgaa aaccatatac caacaacaga agagtacatg 1200
cgcatatcaa aaaaatcagg tgcttaccct ttgctgatat taacctctta cattggtatg 1260
ggtgacatag ccacaaagga gatcttcaat tgggtatcaa atgagccaag aattgttaac 1320
gccgctgcaa ctctttgcag gctaatggat gaaattgttt ccagcgagtt tgaacagaaa 1380
agaggacatg tttgctcatt gttagattgt tatatgaagc aatttgatat gtcgagagaa 1440
gctgctattc aagaatgcaa aaatagaatg acaattgttt ggaaagatat aaatgaagaa 1500
tgtcttaggc caaccgaagt tccgatgcct tttatgactc gtgttcttaa tctttcacgt 1560
tttatggatg ttatttacaa aaacaaagat aactacacgg attctgacgg actaatgaag 1620
acatgtatta aagaagtgtt ggttgatcct gttccaattt ga                    1662

<210> 613
<211> 2092
<212> DNA
<213> Medicago truncatula

<220> 
<223> (E)-beta-caryophyllene synthase

<400> 613
attgaagtac tactatttgt ttgagtcatt tatcttacta tccaataatc caaaatagtt 60
ggaaacaaat taaggtagta attaccccac aaataaaatc atgtcggttt cagtaacatc 120
atcactagtt gctccaaccc ctaatgctaa ctccgatttc tctagacgtt ctgcaaatta 180
tcaccccaac atttgggggg acctttttat tcaatatgtt ttggaaccta tggaatttga 240
tgaaataatg aagcagatta taatgctaaa agaaaaggtg aggcagatgc tagtccctaa 300
cgtaaatgtc acaaaccctt cgagggaagc taatttgatt gattcaatcc aacgtttggg 360
attataccat cattttgagc aagagattgg agaattattg cgacatattg acaataatca 420
tgttgaaaat ggaacaataa ctcttaacga agaccttcat tcaattgcac ttgtctttag 480
gttactaagg caacaaggat atcacatttt gcctgatgtt tttaagaagt tcaagaatga 540
gcaaggaaac ttcaaagaaa cacttgttgg tgatgttgag gggatgctaa gtttgtatga 600
agccacacat atgaggattc atggagagga gatattagat gatgcacttt ctttcacttc 660
cttacacctt gaaatgatga ccactcaatt gagtccttct gttgctacaa aaatcaatca 720
tagcttaaag cggccactct tcaagaactt gcctaggctt gtggcaaggc attacatttc 780
cacttatgag gaagatccat ctcatgatgc aactttgcta ttacttgcca aattagattt 840
caatttgctt caaaaacaac atcagaaaga agttggcgat atttcaaagt ggtggaaaga 900
tttagatttt gcaacaaaac taccttttgc tcgcaataga atagttgaag cttacttttg 960
gatattggga gtgtattttg agcctcaata ctcttttggt agaagaataa tgaccaaggt 1020
gatatccttg gcctcagtaa ttgatgacat atatgatgtt tatggtacaa tagaagagct 1080
acaacttttc actcaagcaa ttgaaaggtg ggatataagt tgcatggatt ttctaccaca 1140
atacatgaaa ttttgttata aagccgtttt ggatgtttat gaagaaatgg agcaagagat 1200
ggtcaaggaa ggcagagcat tttgtgtatt ctatgccaaa aatgaaatga aaagattggt 1260
ccaggcatac tttactgagg ctaaatggtt cagtagaaat tatataccaa cagtggatga 1320
atacatggct cttggaatag taaattctgg ttactatcta atcacagcaa catccttcat 1380
tggaatggga tgcattgcta cagaagatgt tttccaatgg ttaaccaata accccaaaat 1440
tgtcaatgct tcatctaaaa ttgctagact catggatgat attgtttcca atgagtttga 1500
gcaagagaga gggcatggtg cctctgctat tgagtgctac atgaatgaac atggtgtgtc 1560
tagagaagat gcagttaatg aactttcaag acaagtcaca aatgcttgga aggatacaaa 1620
tgaggaactt cttgatccaa ctgaagtgcc aaagcctcta cttatacgag ttctcaattt 1680
gtcacgtgtc attgatgtgc tttataaaga tggagattgc tacactaact cccaaggatc 1740
aacaaagaat gacataatat ctatcttgtt gaatccatgt ccagtatgag taaagggact 1800
tcgctagctt cttcacttgt ccatcttcta ctattagcta tggagttttc agttatgggt 1860
aattagttag ctggttagac ttttttttaa gaagacaaac tagttgctgg aattgacata 1920
agaatgaatc gaacctgaaa ttttaaaagg aatacattcc aaaatctcaa atcaacgcat 1980
tctaagttat agttgttact tgttagttag actaattata gtcgatttca ttttgattat 2040
ataagataaa ttgtacttct ttatataata aaaattatgt ccttatctct ta         2092

<210> 614
<211> 2076
<212> DNA
<213> Medicago truncatula

<220> 
<223> 3S-(E)-nerolidol synthase

<400> 614
ggcacgagga aatctatggc tttttctctt tctttcgcta cttcaaccaa acattcaacg 60
ttttcttcaa acaaaacctc aaatattttg gagtataata aaaccaattt aacttctgtc 120
ttcaatcaaa ttcatattcc taaaagtggt aaatgcaagg atgaccttca tataagacat 180
gctaaagcat tggatgaagt taagcaggta tttgttagaa atataagaaa aaatacggac 240
gaatgtttat ctatggtgga ttccatccaa agattaggca tggagtacaa ttttgaagag 300
gaaattgaag caacacttga aaggaagcac actatgctta gatttcagaa tttccagaga 360
aatgaatatc aaggactgtc acaagctgca tttcaatttc gtatgttgag acaagaaggg 420
tattacatta gcccagacat atttgataag ttttgtgaca acaaaggcaa actcaagtat 480
acattttctg aggatataaa tggaatgatt gcattgtttg aagcttctca attgagcata 540
gaaggagaag actgtcttga caatgtagga cagttctgcg gccaatatct taatgactgg 600
tcatcaacat ttcatggcca ccctcaagcc aaatttgtgg cacacacttt gatgtatcca 660
actcataaaa ctttgtcaag attcacacca acaataatgc aatcacaaaa tgcaacatgg 720
acaaactcta tacagcaatt ttcaaaaata gacactcaaa tggtttcctc ttcacatctc 780
aaagaaattt ttgctgtttc caaatggtgg aaagacttag gtttgccaaa ggacttggaa 840
tttgctagag atgaaccaat taaatggtac tcgtggtcaa tggcatgtct cccagatcca 900
caattctctg aagaacggat tgagctcaca aagcctctat ccctaattta catcattgat 960
gatatatttg atttttatgg aaacattgat gaacttactc tctttacaga tgctgttaag 1020
agatgggact tgtcagctat tgaacaatta ccagactgca tgaaagtgtg tttcaaggct 1080
ctttatgaca taactaatga atttgctctt aggacataca tcaaacatgg atggaatcct 1140
ttaacctcat taataaaatc gtgggtaaga ctcttgaatg ctttcttgca agaagcaaaa 1200
tggtttgctt ctgggaatgt tccaaagtca gaggagtatt tgaagaatgc catagtaagc 1260
actggggtac acgtgatact tgtgcatgct ttcttttgca tgggtcaagg tataactgag 1320
aaaaccgtgt ctctaatgga tgacttccca accattatat ctacaacagc caaaattcta 1380
aggctatgtg atgacttgga aggcgataag gatgttaatt gtgagggtaa tgatgggtcg 1440
tattcgaagt gttacatgaa agataaccca ggagtttcta ttggactaac aaaggagcat 1500
atgagtgaac aaatttcaga tgcatggaaa caactcaaca aagaatgttt gaacacaaat 1560
ccattaccct catcttttac taaactttgt ctcaatgctg cacggatggt accaataatg 1620
tacaattatg atgggaatac tccttcaaag ctagaggagt atgtgaaatc gttgcttaat 1680
gatggtggtt acttacaaag tattcattcc ccaacatcag agcattctac agtatgagca 1740
ttcaaatttt gtgaagtagc tagtctcacc ttcatacaca tactactaga gagaatcacc 1800
aaattacaat gaaatttatg tattacttac ttaacaattg agtgcatgtt tgaaattacg 1860
gtaagtttcc tgattttacc gaacccaagt cacataaagt gtgaatgtac agtcatatgt 1920
gcttgggact tgggagttag gagcaaaatc gatatagtcc ttgtttggtt gtttgggagc 1980
tgggaattag gaggaaaagc atatagacct tctggaggag ggggaaagag aaagatattt 2040
ttcattattt gagattaatg tttgaaaggg aagcta                           2076

<210> 615
<211> 1656
<212> DNA
<213> Mentha x pipereta

<220> 
<223> (Z)-muurola-3,5-diene synthase

<400> 615
atggctacaa acggcgtcgt aattagttgc ttaagggaag taaggccacc tatgacgaag 60
catgcgccaa gcatgtggac tgataccttt tctaactttt ctcttgacga taaggaacaa 120
caaaagcgct cagaaaccat cgaagcactt aagcaagaag caagaggcat gcttatggct 180
gcaaccactc ctctccaaca aatgacacta atcgacactc tcgagcgttt gggattggct 240
ttccattttg agacggaggt cgaatacaaa atcgaacaaa tcaacgccgc tgcagaagac 300
gacggctttg atttgttcgc tacagctctt cgttttcgtt tgctcagaca gcatcaacgc 360
cacgtttctt gcgatgtttt cgacaagttc gtcgacaaag atggcaagtt tgaagaatcc 420
cttagcaata atgttgaagg cctattaagc ttgtatgaag cagctcatgt tgggtttcgc 480
gaagaaagga tattacaaga ggctgtaaat tttacgaggc atcacttgga aggagcagag 540
ttagatcagt ctccattatt gattagagag aaagtgaagc gagctttgga gcaccctctt 600
catagggatt tccccattgt ctatgcacgc cttttcatct ccatttacga aaaggatgac 660
tctagagatg aattacttct caagctatcc aaagttaact tcaaattcat gcagaatttg 720
tataagaaag agctctccca actctccagg tggtggaaca catgggatct gaaatcgaaa 780
ttaccatatg caagagatcg agtggtggag gcttacgtat ggggagtggg ataccattac 840
gaacctcagt actcatatgt tcgaatggga cttgccaaag gcatactaat tattggaatc 900
atggatgata cttatgataa ttatgctaca ctcaatgaag ctcaactttt tactcaagtc 960
ttagacaagt gggatagaga tgaagctgat cgactcccag aatacatgaa aatcgtttat 1020
gaatttattt tgagtacatg tgaaaattat gaacgtgatg cagcgaaact tggaaaaagc 1080
tttgcagctc cttattttaa ggaaaccgtg aaacaactgg caagggcatt taatcaggag 1140
cagaagtggg ttatggaaag gcagctaccg tcattccaag actacgtaaa gaattcagag 1200
aaaaccagct gcatttatac catgtttgct tctatcatcc caggcttgaa atctgttacc 1260
caagaaacca ttgattggat caagagtgaa cccacgctcg caacatcaac cggtatgatc 1320
ggccgatatt gggatgacat cggctctcac ctccgcgaaa gcaaaggagg ggaaatgctg 1380
actgcgttgg atttccacat gaaagaatat ggtctgacga aggaagaggc ggcatctaag 1440
tttgaaggat tggttgagga aacatggaag gatataaaca aggaattcat agccacaact 1500
aattataatg tgggtagaga aattgccatc acattcctca actacgctcg gatatgtgaa 1560
gccagttaca gcaaaactga cggagacgct tatttagatc ctaatgttgc caaggcaaat 1620
gtcgttgccc tctttgttga tgccatagtc ttttga                           1656

<210> 616
<211> 1959
<212> DNA
<213> Mentha x pipereta

<220> 
<223> (E)-beta-farnesene synthase

<400> 616
aaactctgca atttcatata taacatcata aaatcagaga gagagacaga gagtttgttg 60
tagtgaaaaa atggctacaa acggcgtcgt aattagttgc ttaagggaag taaggccacc 120
tatgacgaag catgcgccaa gcatgtggac tgataccttt tctaactttt ctcttgacga 180
taaggaacaa caaaagtgct cagaaaccat cgaagcactt aagcaagaag caagaggcat 240
gcttatggct gcaaccactc ctctccaaca aatgacacta atcgacactc tcgagcgttt 300
gggattgtct ttccattttg agacggagat cgaatacaaa atcgaactaa tcaacgctgc 360
agaagacgac ggctttgatt tgttcgctac tgctcttcgt ttccgtttgc tcagacaaca 420
tcaacgccac gtttcttgtg atgttttcga caagttcatc gacaaagatg gcaagttcga 480
agaatccctt agcaataatg ttgaaggcct attaagcttg tatgaagcag ctcatgttgg 540
gtttcgcgaa gaaagaatat tacaagaggc tgtaaatttt acgaggcatc acttggaagg 600
agcagagtta gatcagtctc cattattgat tagagagaaa gtgaagcgag ctttggagca 660
ccctcttcat agggatttcc ccattgtcta tgcacgcctt ttcatctcca tttacgaaaa 720
ggatgactct agagatgaat tacttctcaa gctatccaaa gtcaacttca aattcatgca 780
gaatttgtat aaggaagagc tctcccaact ctccaggtgg tggaacacat ggaatctgaa 840
atcaaaatta ccatatgcaa gagatcgagt cgtggaggct tatgtttggg gagtaggtta 900
ccattacgaa ccccaatact catatgttcg aatgggactt gccaaaggcg tactaatttg 960
tggaatcatg gacgatacat atgataatta tgctacactc aatgaagctc aactttttac 1020
tcaagtctta gacaagtggg atagagatga agctgaacga ctcccagaat acatgaaaat 1080
cgtttatcga tttattttga gtatatatga aaattatgaa cgtgatgcag cgaaacttgg 1140
aaaaagcttt gcagctcctt attttaagga aaccgtgaaa caactggcaa gggcatttaa 1200
tgaggagcag aagtgggtta tggaaaggca gctaccgtca ttccaagact acgtaaagaa 1260
ttcagagaaa accagctgca tttataccat gtttgcttct atcatcccag gcttgaaatc 1320
tgttacccaa gaaaccattg attggatcaa gagtgaaccc acgctcgcaa catcgaccgc 1380
tatgatcggt cggtattgga atgacaccag ctctcagctc cgtgaaagca aaggagggga 1440
aatgctgact gcgttggatt tccacatgaa agaatatggt ctgacgaagg aagaggcggc 1500
atctaagttt gaaggattgg ttgaggaaac atggaaggat ataaacaagg aattcatagc 1560
cacaactaat tataatgtgg gtagagaaat tgccatcaca ttcctcaact acgctcggat 1620
atgtgaagcc agttacagca aaactgacgg agacgcttat tcagatccta atgttgccaa 1680
ggcaaatgtc gttgctctct ttgttgatgc catagtcttt tgatttgcat aatcaaagac 1740
cctataatta taattatatg tgtttaagaa actaataagc ttgctttatg tatagttgtc 1800
aattgaataa taatgtatta attagtagag ttaagaagtt ataaagaata aagaggagct 1860
ggtagacgta aacaagaaat aatgtgtcaa aataacttca actttttcaa gaataaagaa 1920
ttggaagaga ccaatatata caaaaaaaaa aaaaaaaaa                        1959

<210> 617
<211> 1898
<212> DNA
<213> Mikania micrantha

<220> 
<223> beta-caryophyllene synthase

<400> 617
acgcggggac cacaacacaa tttgagaaga tagttccaat taagcataca tttaagcatg 60
ggttgtaagc aagaatcctt ccggcccttt cgtagcactt ctccaagtgt ttggggggat 120
atgtttctta actacgaaaa gaaagcagag caatgtgatg tagaacttac agttgaagac 180
ttgaaagaaa aagtgagaga agctataaca ggagctttag gcaatccaaa agaacatgtg 240
aatttgctaa aactaattga tgcaatccaa cgccttggta taccgtatta ttttgaagat 300
gagattacaa atgctttgca acatctttat gaagcatatg gtgatgagtg ggttggtggt 360
agcccttcaa tttggtttag actcctacga caacacggct tctatgtttc atgtgatatt 420
tttaacaagt actataagga caaacatgga gattttaagg aatcattaat caatgatgat 480
gaagaaatgg tcgagctata tgaggcaaca agcttgaggg tacggggaga agttgtacta 540
gacgaggcat ttgaatttac aagaaatcat tttgctaaca tagctaagga accccgttgt 600
agcaacgcca ctttgtcaac ccatatacag gtggcattag agacaccttt gcataaaagg 660
ataccaagat tagacgcgtt gcgttacata cgcttctatg aaaaacaagc ttctcataat 720
gaaagtttac ttaaacttgc caagttaggg ttcaacttac ttcagtcact acacaggagc 780
gagcttagcc aagtttctaa gtggtggaaa gatgttgatg tccaaaagaa tttgccttat 840
gctagagaca gaatggttga aagttacttt tgggcaattg gtgtatactc tgagcctaaa 900
tattctcttg gtagagtttt tttagcaaaa gtgattcaat tggcgactgc tatagatgac 960
acttttgatg cttacggtac ttatgaagaa ctccaaactt ttactagggc agttgaaagg 1020
tggagcatta catgcttaga tgagcttcca gagtatatga aactcttgta ccaagtttta 1080
ctggatttat acggagaaat ggaaccaatc atggaaaagg aacaattaac acctctattt 1140
aattgttcaa aagagtttat gatagagact gttaaagcct acatggtgga agcaaaatgg 1200
gtatatgagg ggcacatacc aactaaagat gaacatacat caattgcatt cgcaacaggt 1260
ggtggtccct tgttgatgtc gtcttgctat ctgggcatgg gtgatataat cacgaatgat 1320
tcgatcaatt gggttattag tgaacctcct cttttgaaag ctacaaatat gattggaaga 1380
ttactaaatg atattgtgtc ctctaagaag gagcaagaaa gagtgcattt ccagtctatt 1440
gttcaatgct acaagaaaca gtatgatgtg agtgaggagc atgccattaa cctggtgagg 1500
gaggaaattg aggacgtttg gaaagatatc aacaaggatt cactcaccgc caaagatgtt 1560
ccaaggcctc tcatactagt tgtggtcaac tatgcacgaa cattgtatta tttgtacaag 1620
tataatgata atttctttga agtggaagaa gacatcaaag aggatatcaa atcattgctc 1680
attcatccta tgagcatatg ataattaact tttatgaggc aagccgttca acctcctggt 1740
ggattatgca cgtttgattt taatctaata ataattttag ttaatgttat gtgtattgtg 1800
ttggacttta aataatatcc ccctgtattt ttatgtttta ctaataaata aattgtgttt 1860
ttgcttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                         1898

<210> 618
<211> 1869
<212> DNA
<213> Nicotiana attenuata

<220> 
<223> 5-epi-aristolochene synthase

<400> 618
caatggcctc agcagcagtt ggcaactacg aagaagaaat cgttcgtccc gtcgccgact 60
tctcccctag tctctggggt gatcacttcc tttcattctc cattgacaat catgttgcgc 120
aaaagtatgc tcaagagatt gaaccattga aggaacagac aagaagtatg ctggtagcaa 180
ccggaagaaa attggttgac acattgaatt tgatagacac cattgaacgc cttggcatat 240
cttatcactt tgagaaagaa attgatgaga ttttggatca aatttacaac caaaactcaa 300
acagcagtga tttgttcact tctgcacttc tttttcggtt gctcaggcaa catggtttca 360
acatctctcc tgaaattttc agcaaattcc aagacgaaaa tggcaaattc aaggaatcac 420
ttgctagtga tgtggtagga ttattgaact tgtatgaagc ttcacatgta aggactcatg 480
ctgacgatat cttagaagcc gcacttgctt tctccactat ccatcttgaa tctgcagctc 540
cacatttgaa atctccactt agggagcaag tggcacatgc tcttgagcaa tgtttgcaca 600
agggcgttcc tagagttgag acccgattct tcatctcatc aatatatgag aaggaacaat 660
cgaaaaataa tgtgttactt cgatttgcta ttttggattt caacttgctc cagatgttgc 720
acaaacaaga acttgctgaa gtatcaaggt ggtggaaaga tttggatttc gtaacaacac 780
ttccatatgc tagagatcga gtagttgaat gctacttttg ggcattagga gtttattttg 840
agcctcaata ctctcaagct cgtgtcatgc tcgttaagac catatcaatg atttcgattg 900
tcgatgacac ctttgatgct tatggtacag ttaaagaact tgagacatac acagatgcca 960
tacaaagatg ggatatcaat gaaattgatc ggcttcctga ttacatgaaa atcagttata 1020
aagctattct tgatctttac aaggattatg aaaaggaatt gtctagtgct ggaagatctc 1080
atattgtgtg ccatgcaata gaaagaatga aagaagtagt aagaaattat aatgtcgagt 1140
caacatggtt tattgaagga tatatgccac ctgtttctga atacctaagc aatgcactgg 1200
caactactac atattactac cttgcgacaa catcatattt gggtatgaag tctgcgacag 1260
agcaggattt tgagtggttg tcaaagaacc ctaaaattct tgaagctagt gtgattatat 1320
gccgagttat tgatgataca gcaacgtacg aggttgagaa aagcagagga caaattgcaa 1380
cagggattga gtgttgcatg agagattatg gtgtatcaac aaaagaggca atggataaat 1440
tccaacaaat ggctgagaca gcatggaagg atcttaatga aggacttctt aggccaactc 1500
cagtatctgc agagctttta actcctattc tcaatcttgc tcgtattgtt gaggttacat 1560
atatacacaa tctagatgga tatactcatc cggagaaagt cttaaaacct cacattattg 1620
gcctacttgt ggactctatc gatatttgag ctgccaattg ttgctcatct taaggaaact 1680
acattcttct ttgttgagaa agtagttata taagtttaat tttttcgttt tattgtataa 1740
ttaagttgtt ggggagctgc ttttgcgatt gtgcagtgca cttcctaact aggatctcct 1800
taattaagat ccttgtaaga aataatctac aaagtgttag aatccaaaaa aaaaaaaaaa 1860
aaaaaaaaa                                                         1869

<210> 619
<211> 3063
<212> DNA
<213> Nicotiana tabacum

<220> 
<223> 5-epi-aristolochene synthase

<400> 619
attataccca gcctctccga acccgggttt tgaagatcaa tgctgaccga accaggcggc 60
ggtacgtcat ccgcttgagg gtagagacgg atcagttctt gttgtcgtgt gtcgagctcg 120
ggacgtttgt cacatggctg gacgggttat tcgccgccat caacgtgtcg ccgccaatcg 180
acgagcgcga ctttcccaga gactttagcg tgccacggat caattacatt aactagtctc 240
tcaccactat atatacttgt cccttctctt ccatttaagt agagttcctt tctttcttcc 300
ttaaaactta aaagaacaag taaaaataca ctcatcttta attagcaatg gcctcagcag 360
cagttgcaaa ctatgaagaa gagattgttc gccccgtcgc cgacttctcc cctagtctct 420
ggggtgatca gttcctttca ttctccattg ataatcaggt aatttaacta atactagtat 480
tctttattta tatttatagt ttgttctcca ttgataatca ggtagtttat ttatgttgaa 540
caacattaat tttgctaatt tcagtttaat gtacattaca tataggttgc ggaaaagtat 600
atatatgctc aagagattga agcattgaag gaacaaacga ggagtatgct gttagcaacc 660
ggaaggaaat tggccgatac attgaatttg attgacatta ttgaacgcct tggtatatcc 720
taccactttg agaaagaaat tgatgagatt ttggatcaga tttacaacca aaactcaaac 780
tgcaatgatt tgtgcacctc tgcacttcaa tttcgattgc tcaggcaaca cggtttcaac 840
atctctcctg gtaagttcat catgaagttg ttaaaattat tatccattta ttggaagaag 900
gctaattcat cttgagtttt ctttcttgaa ataccagaaa ttttcagcaa attccaagat 960
gaaaatggca aattcaagga gtctcttgct agtgatgtct taggattatt aaacttgtat 1020
gaagcttcac atgtaaggac tcatgctgac gatatcttag aagacgcact tgctttctcc 1080
actatccatc ttgaatctgc agctccacat ttgaaatctc cacttaggga gcaagtgaca 1140
catgcccttg agcaatgttt gcacaagggt gttcctagag tcgagacccg attcttcatc 1200
tcatcaatct atgacaagga acaatcgaag aataatgtgt tacttcgatt tgccaaattg 1260
gatttcaact tgctccagat gttgcacaaa caagaacttg ctcaagtatc aaggtgcgat 1320
atataaaaac gatgaaccct ttttgattca tcatatctca agtactcatg ttaatttctt 1380
atgctgcagg tggtggaaag atttggattt tgtaacaaca cttccatatg ctagagatcg 1440
agtagttgaa tgctactttt gggcattagg agtttatttt gagcctcaat actctcaagc 1500
tcgcgtcatg ctcgttaaga ccatatcaat gatttcgatt gtcgatgaca cctttgatgc 1560
ttacggtaca gttaaagaac ttgaggcata cacagatgcc atacaaaggt atgaacttca 1620
tcaattcact tattccttga tagtgaatgt cgtcgtgaaa agattaagac gaatttctac 1680
tcattatagt tgtgctcttt caaaatgcat gaattcacct taattttgtc atcctgcaga 1740
tgggatatca acgaaattga tcggcttcct gattacatga aaatcagtta taaagctatt 1800
ctagatctct acaaggatta tgaaaaggaa ttgtctagtg ccggaagatc tcatattgtc 1860
tgccatgcaa tagaaagagt atgttcgagc aacttaacta tcgaaataca ttttttcctt 1920
aatccatttc tcactttggt ttaccttgtg ttcgtctttt agtgattaga aacttgatac 1980
agttcaatca atattttcta acacttgaac acatatatgt tttgtattca cagatgaaag 2040
aagtagtaag aaattataat gtcgagtcaa catggtttat tgaaggatat atgccacctg 2100
tttctgaata cctaagcaat gcactagcaa ctaccacata ttactacctc gcgacaacat 2160
cgtatttggg catgaagtct gccacggagc aagattttga gtggttgtca aagaatccaa 2220
aaattcttga agctagtgta attatatgtc gagttatcga tgacacagcc acgtacgagg 2280
tatgatttgc atctcaagaa attatatcat tatatgggat ttggacaaac aaagtgttgc 2340
gacgacaatt aaggcaatat aaaagctaac ctttaattta tctgctttct aggttgagaa 2400
aagcagggga caaattgcaa ctggaattga gtgctgcatg agagattatg gtatatcaac 2460
aaaagaggca atggctaaat ttcaaaatat ggctgagaca gcatggaaag atattaatga 2520
aggacttctt aggcccactc ccgtctctac agaattttta actcctattc tcaatcttgc 2580
tcgtattgtt gaggttacat atatacacaa tctagatgga tacactcatc cggagaaagt 2640
cttaaaacct cacattatta acctacttgt ggactccatc aaaatttgag ctgccatttg 2700
ttgctcatct caaggaaact tcattcttct ttgttgtata attacgttgt tagggagctg 2760
ttgtgcagtg cacttcctaa actaggacct tcttaagatc cttgtaatca caatattttg 2820
ttctcgatat tcatacctga atatacttgt ttaacacttc aaatgataga aattaaagtt 2880
catccgattt cacttctgtg ctatcagcat atatacattt tttcattccg tccattttct 2940
cctctttgta atttcatgta tatatctagg atgtaataat aactctaaac aacagtttta 3000
tttgggattt ttatcaagcc atacactata tgaaaccttt ttaccctccc tactcaagtt 3060
tca                                                               3063

<210> 620
<211> 1641
<212> DNA
<213> Ocimum basilicum

<220> 
<223> germacrene D synthase

<400> 620
atgactaata tgtttgcatc ggcggctcca atttcaacaa acaatactac cgtggaggat 60
atgcgtcgat cagtcaccta tcatcccagt gtttggaaag atcattttct tgattacgct 120
tcaggcatta cggaagttga gatggaacaa cttcaaaagc aaaaggaaag gattaagacg 180
ttgctagctc agactctgga cgattttgtg ctcaagattg aactaattga tgcaatccaa 240
cgacttgggg ttggctatca ttttgaaaaa gaaatcaacc actccttacg acaaatttac 300
gacacttttc aaataagtag caaagacaat gatattcgtg ttgttgctct tcgttttcgt 360
ctgctaagac aacatggata ccctgttcca agtgatgtat tcaagaaatt tatagacaac 420
caaggaagat tggatgagtc agtgatgaac aatgttgaag gaatgttaag cttgtacgag 480
gcatcgaatt atggaatgga gggagaggat attttggaca aagcattaga aatttctacg 540
tctcatcttg agcctctagc ttctcgttca agaagaatta atgaagcact ggagatgcca 600
attagcaaaa ctttggttag gttgggtgcc agaaagttca tatccatcta tgaagaagac 660
gagtcacgtg atgaagattt attaaagttt gccaaattgg acttcaatat attacaaaag 720
attcatcaag aagagctaac ccatattgca aggtggtgga aggaactaga cttgggaaac 780
aaactaccat ttgcaaggga tagagtcgtg gaatgctatt tttggatttt gggagtctac 840
tttgaaccac aatacaacat tgcaagaaga tttatgacta aagttatagc tatgacttcc 900
atcattgatg atatttatga tgttcatgga actttggaag aactccagcg tttcactgat 960
gctatccgaa gttgggatat cagagctatt gatgaattgc ccccctacat gagactatgt 1020
tatgaagctc ttttaggtat gtatgctgaa atggaaaatg aaatggtaaa gcaaaatcaa 1080
tcataccgca ttgaatatgc aagacaagag atgataaaat tggtaacgac atatatggaa 1140
gaggcaaagt ggtgctatag caagtatatt ccaaacatgg atgagtatat gaagttggct 1200
ctcgtatccg gcgcttatat gatgttggca accacttctt tagttggaat attgggggat 1260
ccaattacaa aacaagattt tgattggatt actaacgagc caccaatttt gcgagcagca 1320
tccgttattt gtagattgat ggacgacgtc gtaggccatg ggatagagca aaaaatatca 1380
agcgtggatt gttacatgaa agagaatggg tgttccaaga tggaggcggt tggtgaattt 1440
tcaaagcggg tgaagaaagc gtggaagaat ttaaatgaag aatgggttga gccaagagca 1500
gcgagtatgg tgattcttgt gcgtgtggta aatcttgctc gtgtaataaa tctattgtac 1560
gtgggtgaag attcatatgg gaattccagc gttaaaacca aggagttgat taaaggtgtg 1620
ctcgtacacc ccataaagtg a                                           1641

<210> 621
<211> 1626
<212> DNA
<213> Ocimum basilicum

<220> 
<223> alpha-zingiberene synthase

<400> 621
atggagtcaa gaaggtcagc aaactatcaa gccagcattt gggatgacaa cttcattcag 60
tccctcgcta gcccgtacgc gggagaaaag tacgcggaga aggccgagaa gctgaaaact 120
gaagtgaaga cgatgatcga tcaaaccaga gatgaattaa agcaacttga gctgattgac 180
aatctgcaaa ggcttggtat ttgccaccat tttcaagatc ttacaaagaa aatcttgcaa 240
aaaatttatg gggaagaaag aaatggtgat catcaacatt acaaagaaaa gggcttacac 300
ttcaccgctc tcagattcag gattctcaga caagatggat atcatgttcc tcaagatgtt 360
tttagtagct tcatgaacaa ggcaggagat ttcgaggaga gtctgagcaa agacacaaaa 420
ggactcgtat ctctatacga agcttcatac ctatccatgg aaggagaaac catacttgac 480
atggccaaag atttctcctc ccaccatctt cataaaatgg ttgaggacgc gacggataaa 540
cgtgtagcca accaaataat ccacagtttg gagatgccac tacaccggcg agtgcagaaa 600
ctcgaggcca tatggttcat acaattctac gagtgtgggt ccgatgcgaa ccctactttg 660
gtggagctag ctaagcttga tttcaacatg gtgcaagcca cgtaccagga agagctcaaa 720
cgcttatcga ggtggtacga agagaccggt ttgcaagaaa agttgagctt cgcgcggcat 780
cgattggcgg aggctttttt gtggtcaatg ggtatcatac cggaggggca ttttgggtat 840
ggaaggatgc atttgatgaa gattggagca tatattactt tactggatga tatttatgat 900
gtttatggaa cattggaaga actccaagtt cttaccgaga tcatagagag gtgggatatc 960
aatttgttgg accagcttcc agaatacatg caaatttttt tcctgtatat gttcaactca 1020
accaatgaac tggcttacga gattttgcga gaccaaggga tcaatgtcat ctcaaatctc 1080
aaaggattgt gggtggaact aagtcaatgc tatttcaagg aagcaacgtg gtttcacaat 1140
ggatacaccc caacaacaga agagtatctc aacgtagcat gcatttcggc atccggtcct 1200
gtcatcctct tcagtggcta cttcaccacc acaaacccca taaacaagca cgagttacag 1260
agcttagagc gacacgctca ttcgctatcc atgattcttc gtctcgcaga tgacttagga 1320
acttcatcgg atgagatgaa gagaggggat gttccgaaag cgatccagtg tttcatgaac 1380
gacacagggt gctgcgagga ggaagcgagg cagcacgtga agcgtctgat cgatgcagag 1440
tggaagaaga tgaacaagga catattgatg gagaagccat tcaagaattt ctgcccgacc 1500
gcgatgaatc ttggaagaat ctccatgagt ttttatgagc atggagatgg ctatggtggc 1560
cctcattcag acaccaagaa gaaaatggtg tccctcttcg tccaacccat gaatatcacc 1620
atataa                                                            1626

<210> 622
<211> 1653
<212> DNA
<213> Ocimum basilicum

<220> 
<223> beta-selinene synthase

<400> 622
atgagtgcaa actgtgtctc tgcagctccc acttcaccaa aaaattcaga tgttgaagag 60
atccgtaaat ccgcaactta tcactctagt gtttggggaa atcattttct ttcatatact 120
tcagacgtta cggaaattac tgcagctgag aaggaacaac ttgaaaaact aaaggaaaag 180
gtgaagaact tgctagcgca aactccagac gaatcaacgg gcaagatgga actcattgat 240
gcaatccaac gactaggggt tggttatcat ttcacaacag aaatccagga gtccttacga 300
caaattcatg aaggacaaat caggaatgac gacgatgatg ttcgtgttgt tgctcttcgt 360
tttcgtctgc tcagacaagg aggctaccga gccccatgcg atgtgttcga aaaattcatg 420
gacgacggag gaaattttaa ggagtcacta aagaaggatg ttgaagggat gttaagcttg 480
tacgaggcat cctattatgg aatagatgga gaggaaatta tggataaagc attagagttt 540
tcatcttctc atctcgagtc catgctgcac aatattagca ctaaaactaa taagtctctt 600
ttgaggcgat tgcaagaagc tttagacaca ccaattagca aggctgcgat cagattggga 660
gccacaaaat tcatatcaac gtaccgagaa gatgagtcac acaatgaaga catattaaat 720
tttgcaaaat tggatttcaa tatattgcaa aagatgcatc aagaagaggc aaactatctt 780
acaaggtggt gggaagattt agatcttgca agcaagttag attttgcaag agatagaatg 840
gtggagagct acttttggag tttgggggtt tatttccaac cacaataccg aacttcaaga 900
atctatctga caaaaatcat ttctattgtt gccgtcatcg atgatattta tgatgtttat 960
ggaagtttcg atgatctccg aagtttcacc gacgttattc aaagttggaa aattagtaat 1020
gctgatgaat tgccaccata catgagaata tgctttgaag ctcttttagg tatttatgag 1080
gatatggggg atcgaattgg ggctccatat gcaatagaca cgatgaaaga attggttgat 1140
acatatatgc aagaggcaga atggtgttac acagaatatg ttccaactgt ggatgaatat 1200
atgaaggtgg cactggttac aggcggttat ctgatggtgg caacaacttt tttaactgga 1260
ataaataata ttacaaaaaa agattttgat tggatcagaa atcgtccacg acttttacaa 1320
gtcgctgaag ttcttaccag attaatggat gacatagcag gccatgggac ggaaaagaag 1380
accacagctg tgagttgcta catgaaggaa tatgaatgct cagagatgga agcttctaga 1440
gagctgtcga agcaagtgaa gaaagcatgg aaagatctga acgatgaatg gatggaacca 1500
agatcttcat ctgcagagat aattggatgc attgtgaata tgtcaagggt cttgcatata 1560
atgtactcca ctggtgatga tggattcagt gattcttcca ctaggactac tcaggctgtt 1620
aaaactttgc tcgtagatca tcccatgaac tga                              1653

<210> 623
<211> 1623
<212> DNA
<213> Ocimum basilicum

<220> 
<223> delta-cadinene synthase

<400> 623
atggatgtca gtattttgag agatgtaagg ccacctgtga cgagttatgc accaaacata 60
tgggctgata cattctccaa catttcttta gatgaagaag tccagaagaa atatgcagaa 120
acaatagagg ctttgaagca agtagttcga ggtatgttaa tggctgctgc aacgcctatc 180
aaacaaatga tattcatcga cacactcgag cgattgggat tggcttatca ttttgagacg 240
gagatcgaac ataaactcca aaaaatatat gacgataacg tttgtggaga cgactgtgat 300
ttattcacga cagcacttcg atttcgtctg ctcaggcagc atcgccacca cgtttcatgc 360
gatgtttttg acaaattctt atacgaagaa ggaaagttta aaggggatgc agaggggcta 420
ttaagcttgt acgaagcatc tcatgttcgt tttcacaacg aaaaaatatt agaagaggct 480
gaaagattta caaggcaaga gttgagctgc tggatcaagt tacaatctcc tcttaaagac 540
aaagtgaaac gagctttgga gcgccccctt catcgagaag tgcccatctt atacgcgcgt 600
cacttcattt cgatttacga gaaggacgag tccatggatg aacaccttct caaactagca 660
aaattcaact tcaatttctt gcagaatttg tataagaaag agctctatga tctatcaagg 720
tggtggaaca aatttgatct caaaacaaaa ttgccataca taagagatcg actggcggag 780
gcttatctct ggggtgtagg ctaccatttc gaaccacaat actcttacgt tcgaaaggga 840
gttgtgttaa gcataaaaat tattggaatt ttggatgata catatgataa ttatgccact 900
gtcaatgaag ctcaactttt tactgaaatc ctagatcgat ggagcatgga tgagattgat 960
cgacttcctg attacatgaa aattgttctt cattttgtta tgagcgcgta cgaagaatat 1020
gagcgcgatg caaagatagt atatgggaaa aagtttgcat ctccttattt caaagaaacg 1080
attcaacaac ttgcaagggg ttataaccaa gagctaaaat gggttatgga aaaacagatg 1140
cctccattca aagactatct gaagaattcg gagataacaa gttgcattta tatcatgttt 1200
gcatctatca taccaggctt gaaatccttt acacaagaag ccattgattg gatcaagaat 1260
gagccaaact tcgcggtaaa agctggtttg atcggtcgct actgggatga cattggctcc 1320
cacaagcgtg agagcaaggg aggagaaatg ctcaccgtga tggactgcta catgaaacaa 1380
tacagtgtgt cgatacaaga gacgatatct gagtttgcca aagcagtgga ggattcgtgg 1440
aaggaagtga acgagggatg ggtttatacg atatccatgt ccaaagagat cactgtgcag 1500
tttctaaact attctcgaat gtgcgatgcg agttacaacc gaaacaatgg agacggttat 1560
acggatccaa gttttgccaa atcaaatatt actgctctat ttgttgatcc tataatcatt 1620
tga                                                               1623

<210> 624
<211> 1731
<212> DNA
<213> Oryza sativa

<220> 
<223> (E)-beta-caryophyllene synthase

<400> 624
atggcaacct ctgttccgag tgtactacta ctacctgtgc ctacctgcac cgatatgcta 60
gtctcaccag tagaaggagg agatctgctg cactgtaaac cccactttga tcaccatcct 120
aatgtctggg gcgattactt tcttaccttc tcaccctgca ctccatcaat gcttctgaat 180
atgaagagaa aagctcatgt ttccgaggaa caagtgagaa ggatgatact tgagtgttct 240
tctggcccca atttgcacgt aaaacttgag ctcgtcgaca ccttagaacg tctttgcatt 300
gactaccact acgagaagga gattgaaaat gtgttgcgcc gggttcatga ggaagaagac 360
gataccgaca atcactatga cctccacact acagctctcc ggttctatct gctcaggaag 420
catggatact atgcctctcc agatgtgttc cagaggttca gggacgagga aggaaatttc 480
acacgcgatg ataacaataa cggcacaaga agcatgctga gcttgtacaa tgctgcccat 540
ctcaggattc atggggagga gatactcgac gatgctatcg tcttcactag gaactatttg 600
cagtctgtgg taaaacatct gcagtcgcca atggcggacg aggtgtgcag tgcacttagg 660
acccctcttt tcaggaggcc aagaagagtt gaagcaaggc actacatctc agtttacgac 720
aagttgccca cacgaaatga gaccattttg gagttcgcca agctcgactt tgggattttg 780
caatctctgt attgcgagga gctcaatatc ctcaccatgt ggtggaaaga gctccaactc 840
caggatcatc taagctttgc gcgagatagg atggtggaga tgcacttttg gatgcttgga 900
gttctcttcg agcctcagta ctcatatggg agaaccatgc tcactaaatt gttcatcttt 960
gtctcgattt tcgatgacat ctacgacaac tacagcacct tggaagaaag caagctgttc 1020
acagaagcaa ttgaaagatg ggatgaggaa gccgctgaag aacttccagg ctacatgaag 1080
ttcttctaca agaaagtact gaccaccatg aaatccatag aaactgatct taaactccaa 1140
gggaacaagc atgtcgacta tgtcaaaaac ctattaatcg acgctacgag atgcttttac 1200
aacgaggtga aatggcgctc tgaaggtgca gatcaggtag ctgctacggt ggaggagcac 1260
ctcaagattt cagtgccaag cagctgctgc atgcacgtcc ctgtctacgc cttcgtcgcc 1320
atgggaaacg atgtcacaac cgatgatgct atcaactggg gcatggccta ccccaagatc 1380
atcacatctt cctgcatcgt tggccgatta ctcaatgaca tagcttcaca tgagagagag 1440
caagggtctt cgtcgtcgtc gtcgtcgacg gtggaagcct gcatgaggga gcacggcggc 1500
atcacgaagg aggaagccta cgcgaagctg agggagctcg tggaggagtc atggatggac 1560
atcgccgggg agtgtctccg gccggcggcg gctcagccgc cgccgctgct ggaggccgtc 1620
gtcaacgcca cacgcgtgct ggatttcgtc tacaaggacg accaagatgc atacactcat 1680
ccaagttcgc tcaaggatac aatacactcc atctacatcc tctctgttta a          1731

<210> 625
<211> 1731
<212> DNA
<213> Oryza sativa

<220> 
<223> (E)-beta-caryophyllene synthase

<400> 625
atggcaacct ctgttccgag tgtactacta ctacctgtgc ctacctgcac cgatatgcta 60
gtctcaccag tagaaggagg agatctgctg cactgtaaac cccactttga tcaccatcct 120
aatgtctggg gcgattactt tcttaccttc tcaccctgca ctccatcaat gcttctgaat 180
atgaagagaa aagctcatgt ttccgaggaa caagtgagaa ggatgatact tgagtgttct 240
tctggcccca atttgcacgt aaaacttgag ctcgtcgaca ccttagaacg tctttgcatt 300
gactaccact acgagaagga gattgaaaat gtgttgcgcc gggttcatga ggaagaagac 360
gataccgaca atcactatga cctccacact acagctctcc ggttctatct gctcaggaag 420
catggatact atgcctctcc agatgtgttc cagaggttca gggacgagga aggaaatttc 480
acacgcgatg ataacaataa cggcacaaga agcatgctga gcttgtacaa tgctgcccat 540
ctcaggattc atggggagga gatactcgac gatgctatcg tcttcactag gaactatttg 600
cagtctgtgg taaaacatct gcagtcgcca atggcggacg aggtgtgcag tgcacttagg 660
acccctcttt tcaggaggcc aagaagagtt gaagcaaggc actacatctc agtttacgac 720
aagttgccca cacgaaatga gaccattttg gagttcgcca agctcgactt tgggattttg 780
caatctctgt attgcgagga gctcaatatc ctcaccatgt ggtggaaaga gctccaactc 840
caggatcatc taagctttgc gcgagatagg atggtggaga tgcacttttg gatgcttgga 900
gttctcttcg agcctcagta ctcatatggg agaaccatgc tcactaaatt gttcatcttt 960
gtctcgattt tcgatgacat ctacgacaac tacagcacct tggaagaaag caagctgttc 1020
acagaagcaa ttgaaagatg ggatgaggaa gccgctgaag aacttccagg ctacatgaag 1080
ttcttctaca agaaagtact gaccaccatg aaatccatag aaactgatct taaactccaa 1140
gggaacaagc atgtcgacta tgtcaaaaac ctattaatcg acgctacgag atgcttttac 1200
aacgaggtga aatggcgctc tgaaggtgca gatcaggtag ctgctacggt ggaggagcac 1260
ctcaagattt cagtgccaag cagctgctgc atgcacgtcc ctgtctacgc cttcgtcgcc 1320
atgggaaacg atgtcacaac cgatgatgct atcaactggg gcatggccta ccccaagatc 1380
atcacatctt cctgcatcgt tggccgatta ctcaatgaca tagcttcaca tgagagagag 1440
caagggtctt cgtcgtcgtc gtcgtcgacg gtggaagcct gcatgaggga gcacggcggc 1500
atcacgaagg aggaagccta cgcgaagctg agggagctcg tggaggagtc atggatggac 1560
atcgccgggg agtgtctccg gccggcggcg gctcagccgc cgccgctgct ggaggccgtc 1620
gtcaacgcca cacgcgtgct ggatttcgtc tacaaggacg accaagatgc atacactcat 1680
ccaagttcgc tcaaggatac aatacactcc atctacatcc tctctgttta a          1731

<210> 626
<211> 1623
<212> DNA
<213> Oryza sativa

<220> 
<223> (E,E)-farnesol synthase

<400> 626
atggcgccgg ctttccaccc tgcgatattc ggtgacttct tcatcaacaa cgtccaacca 60
tcacccaaag agtcagatga atggatggaa gagagagtag atcagttggt tgaggaggta 120
ggtagaatgc ttgaggtttg caaggatgat gtggtaaagc aaatgaacct ggtggatgtg 180
ctccaacgtt tgggaataga tcatcatttt gaggagcaga tcgacaccat tctaaaaaat 240
attcatagag ctgagttcaa tagctctgac ctttacgagg ttgcccttcg gtttcgctta 300
cttaggaaac aagggtattg ggtctcgcca gatgaattca acaaattcaa agctgaagat 360
gggagcttta gtagtgatga cataactaat gatccgaagg gcttgttaag tttatacaac 420
gcagctcacc ttctaactca caacgagaaa gcacttgaag aagctatatt gtttgcaagg 480
catcacctac aattattgag aggcaacctc gcgtacccat tggatgaaca agtaacacgt 540
gcccttgaga taccgttacc aaggaccatg aagagagtag aggtgctaaa ttatatcttc 600
gagtatagcg ctgaagagaa aatgttcaat ccctctattt tggagctagc cgtgcttgat 660
ttcaatattc tacaaaaagt tcaccaaaat gaactcaagg aaatttgtca gtggtgggag 720
aatctttcaa gtgacattag actcgactac gtccgtgaac gtgtggttga gtgctatttt 780
tgtgcatacg ctgcctacta tgaaaaagag cacgcacggg cccgtatgat attcgccaag 840
aggtgtatgc tattttcact gctcgatgat acatacgatg tgcgtgcaac tttagaggag 900
gctcgcaagt ttaacgatgc tctgcaaaga tgggacaaga gtgacgtttc acttctacca 960
gaggacctga agagattttt tctgagcata ataagtaact ttagggagtt tgaggatgaa 1020
ttggaaccac atgagaaata tcgtaattct tacaacatta aagcgtttca aatactatcg 1080
agcaatttcc tccaagaagc agaatggttt catcaaaact atattccatg ctttactgat 1140
catgtgactg tttccctcca gaccggaggt gcaatagagt tacctgttag tttaattgtt 1200
ggcatgggtg atatagcaac taaggaggtg ttggattggg ccttggctaa ccctgatgct 1260
ggtagggcct ttgcagaggt ggcacgattc atggatgact tagctgcatc acacagtggg 1320
agggacaaga tggatgtggc gagcactgtg gagtgttaca tgaacgagca cggggtgacg 1380
agagaggtcg ccgaggcgaa gatcgctgga atggctgagg acgggtggaa aagcatgaac 1440
cagatacgct tcaagcaccg cgcgttcctc ccgttcgtgc agcggatcgc caacctgtgc 1500
atgtccgcca ccctcctata ccatggcaag aagaatggct tcagcaatag cctggagcta 1560
aaggatatgt tcgagagcca ttttgttaac ccaatcccgc ttaatcatat agattacgat 1620
taa                                                               1623

<210> 627
<211> 1641
<212> DNA
<213> Oryza sativa

<220> 
<223> alpha-zingiberene synthase

<400> 627
atgtcatcga cacctgcagc taatttctcc aatgaagacg atgagcgaaa ggctcctacc 60
ggcttccacc ccagcctctg gggcgatttc ttcatcagtt accagccacc tactgcacct 120
aagcatgctt acatgaaaga aagggctgaa gtgctaaaag aagaagttag aaaggtagta 180
aagggctcaa atgaagtacc agagatattg gatcttgtga tcacgctgca acgacttgga 240
ttggatagtt actacaaggc cgagatagat gagcttctct gcactgttta caacaccgac 300
tacaacgata aagatttaca cctagtttct cttcgatttt accttctacg gaagaacggc 360
tatgatgtgt catctgacat atttcaacat tttaaagaca aagaggggag ttttgttgct 420
gatgacacaa gaagtctttt aagcttatat aatgcggcat atatgaggac tcatggtgaa 480
aaagtacttg atgaagcagt tgttttcact actaaccgcc taagatcaga attgaaacat 540
ttgaaatctc cggtagccga tgaagtgtct cttgctcttg atacaccact attccggagg 600
gttagaataa tagaaacaca aaactatatt cctatttatg aaagcgcgac tacacgaaat 660
gaagccatat tagaatttgc aaagttgaat gtcaatctcc ttcaacttat ttattgtgag 720
gagttaaaaa ctatcacacg atggtggaaa gagcttaacg ttgaatccaa cttaagcttc 780
attcgggata gaatagtgga aatgcatttt tggatgacag gagcatgctc ggagccccat 840
tattctcttt tacgaattat acttacaaag atgacagcat ttatcaccat tctagatgat 900
atatttgata catatgctac aaccgaggag agcatgatgc ttgccaaagc gatatatatg 960
tgcaatgaat ctgcaacagt tctacttcca aaatacatga aggatttcta cttatattat 1020
ttaaagacat ttgattcatt tgaagaggca ctaggtccaa acaaaagtta tcgagtgctt 1080
tatttcaaag agctgttcaa gatattaatt aaaggatact ctgaagagat aaaatggcgt 1140
gatgatcatt acattccaaa aacaatagag gaacacctgg aactttccag aatgactgtt 1200
ggtgcctttc aactagcatg tgcttcttta gttgggatgg gtgattttat aacagaggat 1260
actctcgatt atcttttgac ttatccaaaa cttattaagt cttacacaac atgtgtacgg 1320
ctctcaaatg atattgcttc aacaaagcgt gaacaagcag gggaccacta tgcttccaca 1380
attcagtgtt acatgctgca gcatggtaca acaatacatg aagcatgcat tgggataaag 1440
gagttgatag aagattcgtg gaaggatatg atgaaagaat accttgcacc aacaaacctt 1500
cagccaaaaa tcgtggcaag aacagttatt gattttgcac gaactgggga ttatatatac 1560
aagcaagcag attcattcac cttttcacat acaatcaagg atatgatagc atcactttac 1620
gttgagccat atagcattta a                                           1641

<210> 628
<211> 1947
<212> DNA
<213> Perilla frutescens

<220> 
<223> sesquiterpene synthase

<400> 628
acaccatcac cttctgctct cagctctttg taagaatcag cagatctaat taattagcat 60
acaaaatggc ttcagaacaa gcacaaaatc atcggcctgt cgccgatttc tcccccagct 120
tgtggggaga tcagttcatc aaacatgatt cttgtccaca ggttgagaag aagtattcga 180
acacggttga tgttttgaag aaggaagtta agggtatgat aacagctcct ggaaccaaaa 240
tggtcgacac gatggagctg attgacacga tcgaacgtct aggcgtgtcg tatcactttc 300
aagatgagat tgaacataaa ttgcagcagt tttttgatct gaaaccagat tattgcaacg 360
atgatgatga cgcctatgat ttgcacactg ttgctcttca tttccgacta ttcaggcaac 420
atggctatcg tatatcttgc gacatttttg gcagatgggt ccatggggat gggaaattcg 480
aggagatact gaagagtgat gggaagggtt tgctaagtct gtacgaggcg tcgtatctga 540
gaacacgtgg cgaaaccata ctcgacgagg cgcttgactt tgctacggcc agtctgaagt 600
cgatagcgcc atgcctcgaa tcaccccttg ggaaacaagt tgtgcacgcc ctagtgcagc 660
ccttgcactt tggcactcca agaatcgaag cgcgtaattt catctccatc tatgaggaat 720
atgaaggcag gaatgaatct ctcttgatgt ttgctaaaat agactataat ctattgcaaa 780
tgctacataa ggaggagctt catcaagtct cgaggtggtg gaaagagttg gacctgatcg 840
cgaaacttcc atatgcacga gatagagtgg tggagtgttt cttttgggca attggagcat 900
accatgagcc gcaatattct cgtgctcgtg taatgctcac taaaaccatc gccatgacct 960
ctataataga tgacacttat gatgcttatg gtaccattaa agaacttgat atttttactg 1020
aagcaataga gaggtggaat gttaaagaga ctaaaaggct ccccgagtat atgaaaccat 1080
tatataaagc tcttttggaa ctctaccagc aatttgaaca agaactagaa aatgaaggaa 1140
gatcctacgt ggcatactat gccatcgaat ctcttaagga attggtgagg agctatcgtg 1200
ttgaggcaaa gtggtttata caaggatatt taccaccttt tgaagaatac ctaaagaatg 1260
cactcatcac ctgctcttac tgttaccaca caatgacgtc atttttgggg gttgaatcag 1320
ccattaaaga agattttgaa tggctaagca acaaacctaa aatgcttgta gctggccttc 1380
taatatgtcg actcgttgat gacatagcta cttatgaggt cgagaaggct aggggtcagg 1440
ttgctactgg catcgagtcc tacatgaagg ataatggcgc aacaaaagaa gaagccatgg 1500
cgaaattttt cgaaatagct agggatgcat ggaaggatat aaatgaggag tgcttgaggc 1560
caaaccttta taactcgagg gatgtttgga tgcgaatctt gaaccttgaa cgtataatac 1620
acgttgctta caaagacagc caagatggat acactcaacc agaaaaggtt ttgaagcctc 1680
acatcattgc tttgttcgtc gatcccattc aaatttagac attttatttc atggtctact 1740
gaataagccc ctcttctctc tttagttcga tctctctcct tgtttgttcc gatggtgtta 1800
tgtatttcca ttacattaga ggattgaata atacctacat tgtatccttt tctactttgg 1860
tttattttta tgtggtccga tttcatcttt tgcattatga tgtcatatgt aaaatttcac 1920
ttcatcaata tatgtagttg tactgta                                     1947

<210> 629
<211> 1653
<212> DNA
<213> Perilla frutescens

<220> 
<223> valencene synthase

<400> 629
atggcttcag aacaagcaca aaatcatcgc cccgtcgccg atttctcccc cagcttgtgg 60
ggcgatcagt tcgtcaaata tgattcttgt ccacaggttc agaagaagta ttcgaacacg 120
gttgatgttt tgaagaagga agttaagggt atgataactg ctcctggaac caaaatggtc 180
gacacgatgg agctgattga cacgatcgaa cgtctaggcg tgtcgtttca ctttcaagat 240
gagattgaac aaaaattgca gcagtttttt gatctcaaaa cagattattg caacgatggt 300
gatgacgcct atgatttgta cactgttgct cttcatttcc gattattcag gcaacatggc 360
taccgtatat cttgtgacat ttttggtaga tggatcgatg ggaatgggaa attcaaggag 420
ggactgaaga gtgatgggaa gagtttgcta agtctgtacg aggcgtcgta tctgagaaca 480
cgtggcgaaa ccatactcga cgaggcgctc gactttgctg cggctagtct gaagtcgata 540
gcgccacacc tccaatcacc ccttgggaaa caagttgtgc acgccctagt gcagcctttg 600
cactttggca atccaagaat cgaagcgcgt aatttcatct ccatctatga ggaatatgaa 660
ggcatgaatg aagctctctt gaggttagct aaattagact ataatctatt gcaaatgcta 720
cataaggagg aacttcatca agtctcgagg tggtggaaag atttggatct gatcacgaaa 780
cttccatatg caagagatag agtggtggag tgtttctttt gggcagtcgg agtataccat 840
gagccacaat attctcgtgc tcgtgtaatg cttactaaaa ccatcgttat gacctctata 900
atagatgata cttatgatgc ttatggtacc attgaagaac ttgatatttt cactgaagca 960
atagagaggt ggaatgttga agagactaaa aggctccccg agtacatgaa accattgtat 1020
aaagctcttc tggaactcta caagcagttt gaacaagaac tagaaaagga aggaagatcc 1080
tacgtggcat actatgccat cgaatctctt aaggaattgg tgagaagcta tcgcattgag 1140
gcaaagtggt ttatacaagg atatttacca ccttacgaag aatacctaaa gaatgcactg 1200
atcacctgca cttactgtta ccacacaacg acgtcgttgt tgggggttga atcagccatc 1260
aaggaaaact tcgaatggct aagcaacaaa cctaaaatgc ttgtagctgg cctcctaata 1320
tgtcgactca ttgatgacat agctacttat atcctggaga ggggtagggg tcaggttgct 1380
actggcatcg agtcctacat gaaggataat ggcgcaacac aagaagaacc catagctaaa 1440
attttcgaaa tagctacaga tgcatggaag gatataaatg acgaatgctt gagacctagc 1500
ctttacaact cgagggatgt tttgatgcga atatttaacc ttgaacgtat aatagacgtt 1560
acttacaaag gcaaccaaga tcgatacact caaccagaaa aggttttgaa gcctcacatc 1620
attgtcttct tcttcgatcc cattctcatt taa                              1653

<210> 630
<211> 2716
<212> DNA
<213> Picea abies

<220> 
<223> (E)-alpha-bisabolene synthase

<400> 630
cagatcagtc tgtctacaag ccaagccaat caatcaagaa atttgtttgc cattacaata 60
ttgcgtataa ctagtattag ccacttccaa gaatttcaaa tgactagcgt ttctgttgaa 120
tcaggaacag tgtcttgttt gtccagtaac aacttgatcc gaaggacggc caatcctcat 180
cctaatatct ggggttatga ttttgtgcat tctcttaaat cgccttacac tcatgattct 240
agttacagag aacgtgcgga gacacttatt agcgagatta aggtgatgct tggaggtgga 300
gaattaatga tgactccatc tgcttatgac acagcatggg tagcgagggt gccctccatt 360
gatggctctg cttgcccgca atttccccaa acagttgaat ggattttgaa aaatcagtta 420
aaagatggtt cctgggggac tgagtcgcac tttctactgt ccgaccgcct gcttgctact 480
ctttcttgtg ttcttgcgct ccttaaatgg aaagttgcag atgtgcaagt agagcagggc 540
attgaattca taaagagaaa tctacaagca ataaaggacg aaagagatca agacagtttg 600
gtaacagact ttgagatcat ctttccttcc ttgctaaaag aagcgcaatc tctcaacctc 660
ggacttccct acgacctgcc ttatatacgt ctgctgcaga cgaaacggca ggagagatta 720
gccaatctct caatggacaa aattcatggt ggaacattgt tgtcatcttt ggagggcata 780
caagatattg tcgagtggga aacaataatg gatgttcaaa gccaagatgg atctttcttg 840
agctcacctg cttctactgc ctgcgtcttc atgcacactg gagacatgaa atgccttgac 900
ttcttgaaca acgtgctcac taagtttggc agttctgttc catgcctgta tccagtggat 960
ctgctggaac gcctcttgat cgtggataat gttgaacgcc ttggaatcga tagacacttt 1020
gaaaaggaaa tcaaggaagc tctagattat gtttacaggc attggaatga tagaggaatt 1080
gggtggggca gactgagtcc catagcagat cttgagacca ctgctttggg atttcggctg 1140
cttaggctgc atcggtacaa cgtatctcca gtcgttttgg acaacttcaa agatgccgat 1200
ggggaattct tttgctcgac cggtcaattc aacaaagatg tagcaagcat gctgagcctt 1260
tatagagctt cccagctcgc atttcccgaa gaaagcattt tggatgaagc taaaagcttc 1320
agtactcaat atttgagaga agcccttgag aaaagtgaga ctttcagctc atggaaccac 1380
agacaaagcc taagcgaaga gattaaatac gcgctgaaga cttcttggca tgccagtgtc 1440
cccagagtgg aagcaaagag atactgtcaa gtgtatcgcc aagattatgc acacttagca 1500
aaaagcgttt acaagctgcc caaagtgaac aatgaaaaga ttttggagct ggcaaagttg 1560
gacttcaaca ttatccagtc catccaccaa aaagagatga agaatgtcac cagctggttt 1620
agagattcgg ggttgcctct gttcaccttt gctcgggaga ggccgctgga attctacttc 1680
ttaatagcgg gggggacgta tgagccccag tatgccaaat gcagattcct ctttacaaaa 1740
gtggcgtgtt tgcagactgt tctggatgat atgtatgata catatggaac ccctagtgaa 1800
ttgaagctat tcactgaggc tgtgagaaga tgggacctct cttttacaga aaaccttcca 1860
gactatatga aactatgtta caaaatctat tatgacatag ttcacgaagt ggcttgggag 1920
gtagagaagg aacaagggcg tgaattggtt agctttttca gaaagggatg ggaggattat 1980
cttctgggtt attacgagga agctgaatgg ttagctgctg agtatgtgcc tactttggac 2040
gagtacataa agaatgggat cacttccatc ggtcaacgta tacttctgct gagtggagtg 2100
ttgataatgg aagggcaact cctctcgcaa gaggcgttgg agaaagtaga ttatccagga 2160
agacgtgttc tcacagagct gaattccctc atttctcggc tggcggatga cacaaaaaca 2220
tataaggctg agaaggctcg tggagaattg gcttccagca ttgaatgtta catgaaagac 2280
catcctggat gtcaagaaga agaggctctc aatcacatct atggcattct ggagccggca 2340
gtaaaggagc tgacgaggga gtttctgaag gcagaccatg tcccattccc gtgcaagaag 2400
atgctttttg atgagaccag agtgacaatg gtgatattca aggacggaga tggctttggc 2460
atttccaaat tagaagtgaa ggatcacatc aaagagtgtc tgatcgaacc actcccactc 2520
taaccatgac tatgaatcga tgtagagact tgagaacata aatcatctcc tgttgtgatt 2580
gtgctaatta tggaatttcg aattcatttc cttttccctg ctctccctat atctatatgt 2640
actgttttat tgcatatttc cgaaaaataa ataaatcatc tcctcttgtg attatgctaa 2700
aaaaaaaaaa aaaaaa                                                 2716

<210> 631
<211> 2028
<212> DNA
<213> Picea abies

<220> 
<223> (E,E)-alpha-farnesene synthase

<400> 631
aatctgtgac acgcagaatc gctatggatt tggctgtaga aatcgctatg gatttggctg 60
tagatgatgt agaaagacgc gtaggcgatt atcattccaa cctgtgggac gatgatttca 120
tacagtctct ctcaacgcct tatggggcat cttcgtaccg tgaacgtgct gagagacttg 180
ttggggaggt gaaggagatg ttcacttcaa tttcaattga agatggagaa ttaacgagtg 240
atctccttca acgcctttgg atggtcgata acgttgaacg tttggggatc agcagacatt 300
tcgaaaatga gataaaagca gccattgatt atgtttacag ctattggagc gataaaggca 360
ttgtacgtgg gcgagatagt gctgttcctg atctcaactc aattgctttg gggtttagaa 420
ctcttcgact ccatggatac actgtgtctt cagatgtttt taaagttttc caagaccgaa 480
agggggagtt tgcctgctct gccatcccaa cggagggaga catcaaaggc gttctcaatt 540
tactccgggc ctcctacatt gcttttcctg gggagaaagt tatggaaaag gctcaaactt 600
tcgctgcaac atatctaaaa gaagccctgc aaaagattca ggtctcgagt ctttcgcgag 660
agatagagta cgttctggaa tatgggtggc tcacaaattt tccgagattg gaagcgagga 720
attacattga cgtatttgga gaggagattt gtccatactt taagaagcca tgtataatgg 780
ttgataaact tttagaactt gcaaaattag agttcaatct ctttcactcc ttacaacaga 840
cggagttaaa acatgtctcc agatggtgga aagattcggg tttctctcaa cttacattca 900
ctaggcatcg tcacgtggaa ttttacacgt tggcctcttg cattgctatt gaacccaaac 960
attctgcatt cagattaggc tttgctaaag tgtgttatct tggaatagtt ttggatgata 1020
tttatgacac ttttggaaag atgaaggagc ttgaactttt cacagcagca attaagaggt 1080
gggatccatc aaccacagag tgccttcctg aatatatgaa aggagtatac atggcctttt 1140
acaattgtgt caatgaactg gctcttcagg cggagaaaac tcaaggccga gatatgctca 1200
actatgcgcg aaaagcttgg gaagctttat ttgatgcgtt tttggaagaa gcaaagtgga 1260
tctcgagtgg ttatctgccg acatttgagg aatatttaga gaacggcaag gtgagttttg 1320
ggtatcgagc agccacactg caacccatcc tcacgttgga cattcctctt cctcttcaca 1380
tcctgcaaca aatcgatttt ccgtcgaggt ttaatgattt ggcatcttcc atccttcgct 1440
tacgaggtga catttgcggc taccaggcag agaggagccg cggagaagaa gcttcctcga 1500
tatcgtgtta tatgaaagat aatcctggat caaccgagga agatgctctc agtcatatca 1560
acgccatgat cagtgacaac atcaatgagt taaattggga gcttctcaaa cccaacagca 1620
atgttccaat ttcttccaag aaacacgctt ttgacattct gagagctttc taccacctct 1680
acaaataccg agatggcttc agcattgcta aaattgaaac aaagaatctg gtcatgagaa 1740
cagtccttga acctgtacct atgtaactct ccccagtcct gtaactggta gtgtgttatt 1800
tgtgagtgca ctcccctttc cggtagtgtg ttatttgtga atgtccctgt agtgggtgtt 1860
aaggaaatta tctaattaca tccttaacta gtttgttagt tagtttaccg ttacacgagt 1920
tggtaactct gtaacttctt gtaaccatat tgtgtaacta tacatgttca tattaataga 1980
atacacatca atagtgtagt gtgttgcatc aaaaaaaaaa aaaaaaaa              2028

<210> 632
<211> 1737
<212> DNA
<213> Picea abies

<220> 
<223> longifolene synthase

<400> 632
atggctcaga tttctaaatg ttcgtcactg tccgccgagt tgaacgaatc ctccatcatc 60
tctcatcatc atggaaatct gtgggacgac gatttcatac aatctcttaa gtcgtccaat 120
ggggcacctc aatatcatga acgcgctgcg aaacttgttg aagaaatcaa gaatttagtt 180
gtgagcgaga tgaaagattg caacgatgat ttaatcagac gtcttcagat ggttgacatt 240
tttgaatgtc taggaattga tcggcacttt cagcatgaaa tacaagttgc tcttgattac 300
gtgtacagat attggaacca gctggaaggc atcggtattg gatcaagaga ttcccttatc 360
aaagatttca atgctacagc tttgggattt cgggctctcc gactgcatcg atataacgtt 420
tcctcagatg tcttggagaa tttcaagaac gaaaacgggc agttcttctg cagttccacg 480
gttgaagaaa aagaagtgag atgcatgttg acgttatttc gagcttcaga aatttcattt 540
cccggagaaa aagtgatgga cgaggcaaag gcgttcacaa cagaatatct aaccaaagtt 600
ttaacgggag tggatgtaac ggacgtcaat caaagccttt tgagagaagt gaagtatgcc 660
ctggagtttc catggcattg cagtttgccg agatgggagg caaggagctt tatcgaaata 720
tgtggacaaa acgattcatg gctcaagtcg attatgaaca aacgagtttt agagttggcg 780
aaattggact tcaatatttt gcaatgggca catcatagag aactacagct tctgtcaagt 840
tggtggtcac aatcggatat agcgcagcag aatttctatc ggaagcgtca cgtggaattt 900
tacttatggg tggttatagg cacgttcgag ccggagtttt caacatgcag aatcaccttt 960
gcaaaaatct ctacactgat gactattcta gatgacctct acgatactca cggaacgttg 1020
gaacaactca aaatcttcac agagggagtg aaacgatggg atctttcgtt agtagaccgc 1080
cttccagact acataaagat tacattcgaa ttcttcctca acacatctaa tgaattgatt 1140
gctgaagttg cgaaaacgca agagcgggat atgtcagcct acatacgaaa aacatgggaa 1200
cgataccttg aagcttattt gcaagaagcg gaatggatag cagctcgaca cgtccctacg 1260
tttgatgagt acatgaagaa tggcatatcc agttctggga tgtgtatact aaatttgtat 1320
tcgcttctgt taatggggca acttctacct gacgacgttc tggagcaaat acactctcca 1380
tccaagatcc acgagcttgt agaattgacg gccagactgg tagacgactc aaaggatttt 1440
gagacgaaga aggttggtgg ggagttagct tcaggtatag agtgttacgt gaaagacaac 1500
cctgaatgta cactggaaga tgcttcaaat catctaaatg gcctccttga tcttaccgtt 1560
aaggaattga attgggagtt tgtaaggcat gacagcgtgg ccttgtgttt caagaagttc 1620
gccttcaacg ttgcacgagg cctccgactt atctacaaat acagagacgg ctttgacgtt 1680
tctaaccagg agatgaaaac ccacatattc aaaattctca tcgatccact tacttag    1737

<210> 633
<211> 2084
<212> DNA
<213> Pinus taeda

<220> 
<223> (E,E)-alpha-farnesene synthase

<400> 633
ggccaagtgt gtagggcgga gaaatctgtg agacacccgc catcaccatg agttctttgg 60
ctgtagatga tgcagaaaga cgcgtaggcg attatcatcc caacctgtgg gacgatgctc 120
tcatacagtc gctctccacg ccttatgggg catctccgta ccgtgatgtt gctgagaaac 180
ttattggcga aataaaggag atgttcgctt caatttcgat tgaagatgga gacgacgaga 240
tatgttattt ccttcaacgc ctttggatga tcgataacgt tgagcgtttg gggattagca 300
gacatttcga aaatgaaatc aaagcagcca tggaagatgt ttacagccgt cattggagtg 360
ataaaggcat tgcatgtggg cgacatagtg ttgttgctga tctcaactca actgctttgg 420
catttagaac tctacgatta catggataca gcgtgtgttc agatgttttt aagattttcc 480
aagaccaaaa gggggagttt gcctgctctg ccgatcagac agagggagag atcaaaggca 540
ttctcaattt actgcgggcc tcgctaattg cctttcctgg ggagagaatt ctgcaagagg 600
ctgaaatctt cgctacaaca tatttaaaag aagccctgcc aaaaattcag ggctcccgtc 660
tttcgcaaga gatagagtac gttctggaat atgggtggct cacagattta ccgagactgg 720
aaaccaggaa ttacattgaa gtattagcag aggagattac tccatatttt aagaagccat 780
gtatggcggt tgaaaagctg ttaaaacttg caaaaataga gttcaatctc tttcactcct 840
tacaacaaac agagttaaaa catctgtcca gatggtggaa agattcaggt ttcgctcaac 900
ttacattcac taggcatcgt catgtggaat tttacacgtt ggcctcttgc attgctatgg 960
aacccaaaca ttctgcattc agactgggct ttgctaaact gtgctatctt ggaatagttt 1020
tggatgatat ttatgacact tacggaaaga tggaggagct ggaacttttc acagcagcaa 1080
ttaagagatg ggatacatcg accacagagt gccttcctga atatatgaaa ggagtataca 1140
tggcatttta cgattgtgtt aatgaaatgg ctcgacaggc ggaaaaaact caaggctggg 1200
atacgctgga ctatgcgcga aaaacttggg aagctttaat cgatgcgttt atggaagaag 1260
caaagtggat ctccagtggt tatgtgccca catttcagaa atatttagac aacgggaagg 1320
tgagttttgg gtatcgagca gccactctcc aacccatcct cacgctggac attcctcttc 1380
ctctacacat cctgcaagaa atcgattttc catccagctt taatgatttg gcatcttcca 1440
ttcttcgctt gcgaggtgac atttgcggct accaggccga gagaagtcgt ggggaacaag 1500
cttcttcgat atcctgttat atgaaagata atccgggatc aactgaggaa gatgctctga 1560
gccatgtcaa cgccatgatc ggtgacaaga tccctgagtt taattgggag tttatgaaac 1620
ccagcaaggc tccaatttct tccaagaaat acgcttttga cattctcaga gctttctacc 1680
acctctacaa ataccgagat ggcttcagca ttgccaaaat tgaaacaaag aaattggtga 1740
tgagaactgt ccttgaccct gtaccaatgt aagtctatca ataaagtctg agtcctttcg 1800
agaactgtcc ttgaccctgt accatgttaa gtcctatcca aaaagtctga gtcctattga 1860
gtacaggcaa tacatatgga acatggaagc ctaaggaagc ttaataacat tataagagta 1920
aatgttcttt taacttttat gagaagtctt tttagactca agtaattacc ccatttcatc 1980
atggaactta tcagtgtttc gttagtgtat ttttaaaagg ttgattttca atttttatga 2040
aaataggttg atatttctga tactaaaaaa aaaaaaaaaa aaaa                  2084

<210> 634
<211> 2602
<212> DNA
<213> Pisum sativum

<220> 
<223> ent-kaurene synthase A

<400> 634
atcacacatc actctaaaac taaacattac ttacttcttt ccatcatcac catgtttact 60
cacttctcca cccactttca tcttccatct tcttcttctc tcttctttct tcatccattc 120
tacaaatcct cttctttagg tgctgtgtcg tttgtggcta aagacaaaga gaaaagatgt 180
agagctatat ccaaatcaag aactcaggaa tatgaaggag tatttcaaac taatgtagca 240
acattaaagt tgagtgaaat taatgtggaa gatgtcatag tcatagatga tgaagaggag 300
caagatatta gggtgggttt agtgaacaaa ataaaatcaa tattgagttc attggaagat 360
ggagagataa ctatatctgc ttatgatact gcttgggttg ctcttgttga agatgttaat 420
gctattagca cccctcaatt tccttctagt ctagagtgga ttgcaaaaaa tcaacttcaa 480
gatggttcat ggggtgatag ccgattattc tcggctcatg atcgaattat caatacattg 540
gcatgtgtaa tcgcgttacg atcatggaat atgcattcag aaaagtgtga caaaggaatg 600
atatttttta gagagaatct tagcaagctt gagaatgaga atgaggagca tatgccaatt 660
gggtttgaag ttgctttccc ttcactactt gaaggagcta gagggattaa accattgatg 720
tgcccaaatg attctccaat attgaaaaac atatttgaaa agagagatga aaaactcaca 780
agaataccaa aagagataat gcataaagtg ccaacaacat tgttgcatag cttggagggt 840
atgtctggct tggattggaa acaacttcta aaattgcaat cacaagatgg atcattcttg 900
ttttctccat cttccacagc ttttgcatta atgcaaacta aagatggaaa ttgcctaaaa 960
tacttgaata atgttgtcaa aaaattcaat ggaggagtcc caaatgtgta tccggtggat 1020
ttatttgaac atatttgggt ggttgatcgt ctcgaacgcc ttggaatatc tcgatttttt 1080
cgacatgaga tcaaagattg tatgaattat gtgtctaaga tatggagtga aaaaggaatt 1140
tgttgggcaa gaaattcaaa tgttcaagat attgatgaca cagcaatggc tttcagatta 1200
cttagattac atggtcacca agtttcagcc catgtgttta agcactttga gagaaatggt 1260
gaattcttct gctttgctgg tcaatgcaca caagcagtga caggaatgta taatctattt 1320
agagccagtc aagtgctttt tccaggagag aaaattcttg aacatgccaa acacttttct 1380
gccaaagttt tgaaggaaaa gagagaagca aatgaactca tagataagtg gatcataatg 1440
aagaatctgc ctgaagaggt tggttatgca ttggacatgc catggtatgc aaatttagat 1500
cgcattgaga caagatttta cattgatcaa tatggtgctg aaagcgatgt atggattggc 1560
aaaactcttt acaggatggc gtatgtgaac aacaacaatt atctcgagct tgctaaatta 1620
gactacaaca attgtcaagc acaacattta atcgaatgga atgtaattca aacatggtac 1680
ttagaatcta gattgggcga atttggattg agcaaaaggg atcttttatt ggcttatttt 1740
ttggccaccg ggagcatatt tgagcctgaa agatctcatg agagacttgc ttgggcaaaa 1800
actacggctc tccttgagac aatcaagtgt tatgttagga atgaagattt gaggaaagat 1860
tttgcgaaaa aattcaatga ccacatcgat gttcgagact attctattgc ccggaggatg 1920
aagaggaaca aaacagaaca tgaacttgtt gagagtctgt ttgcaaccat aggtgaaata 1980
tcatgggatg taagattgtc ttatggtcat gaaattggat atgatatgca tcaatgttgg 2040
aaaaagtggc tttcaagttg gcaaagtgaa ggagacaaat gtgaaggaga agcagaactt 2100
ttgatacaaa taataaacct atgttctaac cattggattt ctgagggacc aagtatgcaa 2160
tccacaatac agcatcttct tcaactcact aactctatat gccataaact tagttgctat 2220
caaaaggaca aggaattaaa aggcatcagc tgccaggaaa acatcaccaa ctcagaagta 2280
gagtccaaaa tgcaagaact tgtacaaatg gtgtttcaaa aatgtcctaa tgacattgat 2340
tttaatgtca agaatacttt cttcacaatt gcaaagtcct tttactatgc agctttctgt 2400
gattcaagga ccatcaactt tcatattgca aaagttctct ttgaaaaagt tgtttaatca 2460
aatttattga tttgtatagg tattagttca ctttcattca tgtgaatata tattttccct 2520
ttaatgtaat attgaaacaa aaaggaaaat atttgttatt gtgattcaat gtgtatatat 2580
tgtcgttttc taataaattt ca                                          2602

<210> 635
<211> 1638
<212> DNA
<213> Pogostemon cablin

<220> 
<223> (-)-germacrene D synthase

<400> 635
atggatttga atgaaatcac ctcttcatct cgtcctctcg caaattatca cccaaatgtg 60
tggggagacc gtttccttct gcatgaacca gaattcactt gccaggctgg tgagaaacaa 120
ctagttgaag agctgaaaga ggaagtgaga agggagctga aggaagcgtc gaacgactac 180
cttcgacagc tgaagatggt ggacgcaata caacgactag gcatcgagta tctctttgag 240
gaagagattg atgaagctct gagaaatctg ttggcaaaat tcgagaatta ttgcaaggat 300
aatcatgata tgtacgccac tgctcttagc tttcgccttc tcagacaaca cggatacaag 360
gtttcatgtg aagtttttga caagtttaag gatggggaag atggattcaa ggtggaagaa 420
gtgatggcag ttctcgagtt gtttgaggct acacatatga gaattcatgg agaagatgtg 480
ctcgatcaag cctttgtttt cacaaggaat taccttcaat caattcacgc aaccttgagt 540
aatccaattg ctaaacaagt tcacaacgca ttgaatggat actcttgtcg gagaggaatg 600
ccacgaatcg aagcgaggaa gtatataccc atctacgagg aatacggttg tcaccataaa 660
gccttgctca aacttgctaa gctcgatttc aatctacttc aatctatgca caaaagggag 720
ttgactcaac tttataggtg gtggaaagat ttggaaatgc caacaaagct accgtacata 780
agagatcgat tggtggagac atacttttgg gacatggggt tttattttga accacaatat 840
gctctagcta gaaatatctt agtcaaagta caatgtttgg tgtctatttt cgatgacact 900
tttgatgcat atggtgcttt taaggaatta caactcttca aagatgccat tgatagatgg 960
agtatctcat gcttagatga acttccagag tatatgcaga taatctacaa actggttttg 1020
gacgtgtttg aagaaattga gagtcatatg atcaaacaag gaacatcgta tcgtctggac 1080
tatgcaagag aagcgataaa aattgtgatt ggaggttact ttgatgaggc aaaatggagg 1140
gaagaagagt acaagccaag aatggaagag tacatgaaag tagctacaaa gagtgcagcc 1200
tacttaactc taatcatagt atcatttgta gggatgaaaa atgacattgc caccccacaa 1260
gccttccaat gggtcctttc tgaacctcaa attattacag cttctttagc tcttgccagg 1320
ctctccaatg atctcgtggg cattgagttt gagaaagaga gaaagtatat agcgacagca 1380
gtggagttgt acgaggaaga gcataaagtg tcaaaagaag aggctgtgtt ggaattgagg 1440
catgaaacag agtcggcatg gaaggaaatt aatgaggcgt tgttagagcc aactacattt 1500
gcgaccccaa ttcttgatcg tatacttaat tccgcccgag tacttgaagt tttttacgac 1560
aagaccgacc gctacacaca tgtggatctt gaattgcaga atatcatcgc ccaactatac 1620
attcacccta ttccttaa                                               1638

<210> 636
<211> 1665
<212> DNA
<213> Pogostemon cablin

<220> 
<223> (-)-germacrene A synthase

<400> 636
atggaattga aaaaccaaag tgttgcaata atctccagca atgcttctcg cccacttgcg 60
cattatcatc cagacgtatg gggagatcgt ttccttctct acaaaccaaa tcccagttct 120
gaggctggtc agaaaccagt tattgaagag ctgaaacagc aagtgagaag cgagctgaag 180
gaagcatcga acgactacat gcgacagctg aagatggtgg acgcaataca acgacttggc 240
atcgagagtc tctttgagga agacattgat aatgcattga agaatctgtc tgaaaatttt 300
gatgattact gcaaagataa gcatgatttg tatgccattg ctcttagctt tcgccttctc 360
agacaacatg gatacaggat ttcatgtgat gtattcgaca agttgaagga tggcgaagat 420
ggattcaaag ttcccccttc agatgaagcg cttgcagttg tagagttgtt agaggccacg 480
catctaagaa tccatggaga agttgtgctt gatcgtgcct ttgttttcgc caggattcac 540
cttgaatcga ttgaagcaaa tttgaataat ccagtcgcga aacaagttca taacgcgttg 600
tatggatact ctaatcggag aggaatgcaa caagtagaag cgaggaagta catacccatc 660
tacgagcaat atgcttctca tcatcaaggc ttgctcaaac ttgctacgct gaattttaac 720
ctgcaacaaa ccatgcacaa aagggagttg agtgaacttt caaggtggta tagagattta 780
gaagttccaa caatgttacc atttgctaga caacgattgg tggagacata cttctgggac 840
gctggagtag tttttgaacc agaaaatgat gttgccagga tgattttagt caaagtgcaa 900
tgcctaatct cttttcttga tgatactttt gatgcatatg gaagttttga ggaactacaa 960
ctcttcacgg atgcaattaa tacatgggat gtttcatgtt tagatcaact tccagattat 1020
atgaagataa tttacaaagc ccttttggga gtgtttgaag taattgagaa actaatgatc 1080
aaacaaggaa cattgtatcg tctcaactat gcaaaagaag cgatgaaaat agtggtggga 1140
ggttactttg ttgaggctaa atggagggaa gaaaagagca aacccacgac gcaagagtac 1200
atgcaggtag caacaaagag tgcaggatat atgactctta ttataacatc atttcttgga 1260
atggaagcaa atattgccac caaagaagcc ttcgattggg tgctttctga gcctgatgtt 1320
atgaaagctg caataactct tgccaggctc accaatgata tcgtcggaat tgagctcgag 1380
aaagaaagaa agcatatagc tacagcagtg gaagtgtacg aggacgagca taaattgtcc 1440
atgcaagagg ccatggttga aatcaagaat caaatcgagt cgggatggaa gaccataaat 1500
gaggcgtttc ttagaccaac taaatttcca acacctatac tttatcgtat actcaattac 1560
tgcagagttc ttgaggttat ttacgacaag agcgatcgct acacacatgt ggatcctgca 1620
ttgcaagaca tcatcaagca actatatatt caccctattc catag                 1665

<210> 637
<211> 1665
<212> DNA
<213> Pogostemon cablin

<220> 
<223> (+)- germacrene A synthase

<400> 637
atggctgtac aaatctccga aactgttcgc cctttcgcca atttttctcc caatcccagc 60
ttgtggggtg atcaattcat caaccacaaa tctaaaactc agcaaatatc gaggatatat 120
ttggaggaaa ttgaagggtt gaaaaatgaa gtaaagtgta tgctaacaag taccccagag 180
ggaaagatgg cggacaccgt caacctgatc gacacactcg agcgcctagg ggtatcgtat 240
catttcgaaa aggaaatcga agagaagatg aaacacttat tcaatctgat caaagcggat 300
aactataaag atcatgaagg ctgtgatttg tatactgatg ctcttcattt tcgattattc 360
aggcagcatg gttaccctat atcttctggg atttttaaca aatggatgga tgggaatgga 420
aaattcaagg agagcattaa gagtgatgca aagggtttgt tgagcttgta tgaagcatgc 480
tgtttgagaa cacatggaga caccctactc gacgaagccc ttgtttttgc tacggccagt 540
ctgaaatcca tggcagcaaa ccttgcgtca cccctaagga aacaggttga gcatgccctc 600
ttccagcact tgcattttgg cattccaaga gtcgaagcac gacacttcat caccttctac 660
gaagaggaag agcacaagaa tgagatgctg cttaggttcg ccaaattgga ctttaatgca 720
ttgcaagcac tgcacaaaga ggagctgagt gaaatcagca agtggtggaa agatttggat 780
ctcatctcga aacttccata tgcaagagac agggtggtag agtcttactt ttgggcagtg 840
ggagtgtact atcaacccaa gtactctcgt gcccgtatta tgctcactaa aaccattgcc 900
atgacggcta tattggatga cacctatgac tcttatggta cacttgaaga acttgatgtt 960
ctcacaaagg caattgagag gtgggatatc aaagaaatta atggactccc agagtacatc 1020
aaaggattct ataaacaggt gctgaaactc tatcagcaat tagaggaaga attagcaaag 1080
gaaggaagat cttatgctgt atactatgca atagaagctt gtaaggaatt ggcgaggagc 1140
tacgctgtgg aggcgaagtg gttcaagaaa gggtacttgc ccggatttga ggagtaccta 1200
atcaattctc tcgtcacctc cacggctggc tatctcaata taatctcgtt ttttggcgtg 1260
gaatctgtaa ccaaggaaga ttttgaatgg tttagcaaga agcctagaat cgctgtagcc 1320
actcagataa ttacaagagt tatcgatgac attgcaactt atgaggtaga gaaggagaag 1380
ggtcagagtg ccacaggaat agattgctac atgaaggaac atggggtgag caaagagaag 1440
gcaatgcaga gattctatga aatgagtacc aatgcatgga aggatattaa tgaggaaggc 1500
ctcagttggc catcttcttt ttccagggat attttcgtcc aactccgaaa ttttagtcgc 1560
atggttgatg ttacctatgg caaaaatgaa gatggatact ccaaacccga aaagattctc 1620
aagccactta tcattgctct gtttgttgat cagatcaagc tttaa                 1665

<210> 638
<211> 1659
<212> DNA
<213> Pogostemon cablin

<220> 
<223> patchoulol synthase

<400> 638
atggagttgt atgcccaaag tgttggagtg ggtgctgctt ctcgtcctct tgcgaatttt 60
catccatgtg tgtggggaga caaattcatt gtctacaacc cacaatcatg ccaggctgga 120
gagagagaag aggctgagga gctgaaagtg gagctgaaaa gagagctgaa ggaagcatca 180
gacaactaca tgcggcaact gaaaatggtg gatgcaatac aacgattagg cattgactat 240
ctttttgtgg aagatgttga tgaagctttg aagaatctgt ttgaaatgtt tgatgctttc 300
tgcaagaata atcatgacat gcacgccact gctctcagct ttcgccttct cagacaacat 360
ggatacagag tttcatgtga agtttttgaa aagtttaagg atggcaaaga tggatttaag 420
gttccaaatg aggatggagc ggttgcagtc cttgaattct tcgaagccac gcatctcaga 480
gtccatggag aagacgtcct tgataatgct tttgacttca ctaggaacta cttggaatca 540
gtctatgcaa ctttgaacga tccaaccgcg aaacaagtcc acaacgcatt gaatgagttc 600
tcttttcgaa gaggattgcc acgcgtggaa gcaaggaagt acatatcaat ctacgagcaa 660
tacgcatctc atcacaaagg cttgctcaaa cttgctaagc tggatttcaa cttggtacaa 720
gctttgcaca gaagggagct gagtgaagat tctaggtggt ggaagacttt acaagtgccc 780
acaaagctat cattcgttag agatcgattg gtggagtcct acttctgggc ttcgggatct 840
tatttcgaac cgaattattc ggtagctagg atgattttag caaaagggct ggctgtatta 900
tctcttatgg atgatgtgta tgatgcatat ggtacttttg aggaattaca aatgttcaca 960
gatgcaatcg aaaggtggga tgcttcatgt ttagataaac ttccagatta catgaaaata 1020
gtatacaagg cccttttgga tgtgtttgag gaagttgacg aggagttgat caagctaggc 1080
gcaccatatc gagcctacta tggaaaagaa gccatgaaat acgccgcgag agcttacatg 1140
gaagaggccc aatggaggga gcaaaagcac aaacccacaa ccaaggagta tatgaagctg 1200
gcaaccaaga catgtggcta cataactcta ataatattat catgtcttgg agtggaagag 1260
ggcattgtga ccaaagaagc cttcgattgg gtgttctccc gacctccttt catcgaggct 1320
acattaatca ttgccaggct cgtcaatgat attacaggac acgagtttga gaaaaaacga 1380
gagcacgttc gcactgcagt agaatgctac atggaagagc acaaagtggg gaagcaagag 1440
gtggtgtctg aattctacaa ccaaatggag tcagcatgga aggacattaa tgaggggttc 1500
ctcagaccag ttgaatttcc aatccctcta ctttatctta ttctcaattc agtccgaaca 1560
cttgaggtta tttacaaaga gggcgattcg tatacacacg tgggtcctgc aatgcaaaac 1620
atcatcaagc agttgtacct tcaccctgtt ccatattaa                        1659

<210> 639
<211> 1638
<212> DNA
<213> Pogostemon cablin

<220> 
<223> gamma-curcumene synthase

<400> 639
atggctgctt ttactgctaa tgctgttgat atgaggcctc ctgtcatcac cattcatccc 60
cgttccaaag atatcttctc tcagttttcc ttggacgata agcttcagaa gcagtacgca 120
caaggaattg aagctctgaa ggaagaagca agaagcatgt taatggctgc aaaatcagcc 180
aaagtcatga tactaataga cacactcgag cgtctgggat taggatatca ttttgagaag 240
gagatcgaag agaaactcga agcaatatac aagaaggaag atggtgacga ctatgatttg 300
ttcactactg cgcttagatt tcgtctgctc aggcaacatc agcgccgtgt tccctgcagt 360
gtttttgata agtttatgaa caaagagggc aagtttgagg aagaaccctt gattagtgat 420
gtggagggac tactgagtct gtatgatgca gcctacctgc agatccatgg ggaacacatc 480
ttgcaagaag ccctaatttt cacaacacat catttaactc gtatcgagcc acaattagac 540
gatcactctc cccttaaact caaactgaat cgagctttgg agtttccttt ttatcgagag 600
atccccatca tttatgcaca cttttacatc tccgtttacg agagggatga ctctagagat 660
gaagtgcttc tcaaaatggc aaaattgagc tacaatttct tgcaaaattt gtacaagaaa 720
gagctttctc aactctccag gtggtggaat aaattagaac taataccaaa cctaccatat 780
ataagagaca gcgtggcggg tgcctatctt tgggctgtag cattatattt cgaacctcaa 840
tattctgatg tccgaatggc cattgccaaa ttaatacaaa ttgctgctgc agtagatgat 900
acatacgata attatgcgac cattcgagaa gctcaacttc ttactgaagc tttggagagg 960
ttgaatgtgc atgaaattga tacccttcct gattatatga aaattgttta tcgtttcgtt 1020
atgagttggt cagaagattt cgaacgagat gcaacaatta aagaacagat gcttgcaact 1080
ccctacttca aagcggagat gaaaaaactt ggaagggctt acaatcaaga gctgaagtgg 1140
gttatggaaa ggcaattgcc ttcatttgaa gaatatatga aaaattctga gattacgagt 1200
ggtgtgtata taatgttcac tgtcatttca ccatacttga attctgctac acaaaaaaac 1260
attgattggt tgctgagtca acctcgtctc gcttcatcca ctgccatagt tatgagatgc 1320
tgcaatgact tgggcagcaa tcaacgcgag agcaagggtg gagaagtgat gacttccctg 1380
gattgctaca tgaaacaaca tggtgcatca aagcaagaaa ccatatctaa atttaaacta 1440
ataattgagg atgaatggaa gaatttgaac gaggaatggg cagcgaccac ttgtttgcca 1500
aaagtaatgg tggagatatt tcgcaactac gcaagaattg caggtttctg ttacaaaaac 1560
aatggagatg cttatacgag tcccaaaata gttcagcaat gttttgatgc cctttttgtt 1620
aaccctctac gcatttga                                               1638

<210> 640
<211> 1877
<212> DNA
<213> Populus balsamifera

<220> 
<223> (-)-germacrene D synthase

<400> 640
acagtatacc cttcaaaaca caaacgatcg aacctcagaa acccactaat tcccaaacca 60
tactaggaaa atgtctgttg aaggttctgc aattttctct actgccactg tcgagcccaa 120
tgttagtcgc cgttcggcag gttattctcc tagcatttgg ggtgaccatt ttctctcgta 180
cgcaaccgat tccatggaaa cgagtgacaa agcagagcat aaaaaactga aggaagaagt 240
gaaaagggag ctgatggcca atatcaataa gccttcacaa acactggact tcattgatgc 300
gatccaacgc ttaggcatct cttaccattt tgagattgag attgatgaaa tactaagaga 360
aatgtacaag tcccattgcg acttcgataa tggagatgat gatgatcatc atcataatga 420
cctatacgcc atttctctca aatttcgact gcttagacaa caaggttata aaatctcatg 480
tgatgtgttc ggcaaattca agaacagcca agggaccttc aatgattccc ttgccaatga 540
cactcgagga attttaagct tatatgaagc tacacatctc cgggtgcatg gagatgaggt 600
attagaagaa gcacttgtgt tcactacttc ccacctagag ttcttggcca cccattcaag 660
ctctccgctg agagcaaaaa taaatcatgc tttaaagcag cctgttcgca agaacatacc 720
aaggctagaa gcaaggcatt atttctctat ctaccaagaa gatccttcat gtagtgaagt 780
tttactgaac ttcgctaaat tagacttcaa cattttgcaa aagcaacacc agaaggaact 840
aagtgaaatt gcaaattggt ggaaagaatt agattttgct aagaagctgc cttttgcaag 900
agacagagtt atagagtgct acttttggat actaggagtg tacttggagc cagagtattt 960
cttggctcga aggatactga ccaaagttat tgccatgact tccgtcatcg atgacatcta 1020
cgatgtctat ggtacaccgg aagaactcga gctctttact gatgcaattg agaggtggga 1080
aattactgcc gtagatcagc tgccagagta catgaaagtg acttacaagg cacttctaga 1140
tgtctacaca gaaattgagg aaaatatggt cactgaagaa agatcatacc gtgtctacta 1200
tgcaaaagaa gcaatgaaga atctagttcg agcctactac cttgaatcta aatggttcca 1260
ccaaaaacac acaccaacaa tggaggaata catggctgtt gcattggtca cttcgggcta 1320
tgcaatgcta gcagctacat cctttgttgg aatgggacat gttgtaacta aggactcctt 1380
cgattggtta tttaggggac ctaagattct taaagcctca gaaataattt gcaggctcat 1440
ggatgacatc gtgtcccaca agttcgaaca aaagagaggg catgttgcct cgagcattga 1500
atgttacatg aaacagcatg gcaccacaga acaagaaact gtccacgaat ttcgaaaaca 1560
agttacagat gcttggaagg atctcaatga agagtttctc cacccaaccg ctgtccccat 1620
gcctcttctg acaaggatgc tcaatcttgc tcgtgtgatt gatgttgtgt acaaagatga 1680
agatggctat acaaatgctg gaactgtgct caaagatctt gtttctgctc tactcattga 1740
tcctgtgcca atgtgatcag ctagtaatta agacttaaac ctgtcatgtt gctgaactaa 1800
taggattaaa atcctctatc accagtaaat actgtgatgc tgattcaacc ggtccaataa 1860
attttttctc tgtttta                                                1877

<210> 641
<211> 2528
<212> DNA
<213> Pseudotsuga menziesii

<220> 
<223> (E)-beta-farnesene synthase

<400> 641
aagccaaatt tgtttgccat tcccttccaa attatagctc atattttatg agcttggaag 60
aattttatcc aatggctacc gtttatgtac cttcttctac tctgccttgt gctttgtcga 120
cgagtagcag tagcagcagc ttggtcagaa ggacggccaa tcctcatcct aatgtctggg 180
attatcattt tgtacaatct cttcaatcgc cttacactga tccttgctat ggagaacgtg 240
tggagacact tgttgctgag attaaggcga tgcttcatgg tgaaggaggc ttaatgatca 300
ccccatctgc ttatgacaca gcttgggtag ccagggtgcc ctccattgat ggctctgctc 360
gcccgcaatt tcctcaaaca gttcaatgga ttttgaaaaa ccagttaaaa gatggttctt 420
ggggtactga atcgcacttt ctactgtccg accgactgct tgccactctt tcttgtgttc 480
ttgcgctcct taaatggaaa gttggggatc tgcaagtaca gcagggcatt gaattcataa 540
agagcaatct agaagcaata aaggatgaaa acgatgaaga cagcttggtg acagactttg 600
acatcatctt cccttccttg ttaagagaag ctcaatatct agacattgaa cttcccctac 660
aacctgcctt atgtaagtct actccaccca agcggcagga gagattagca aatatgtcaa 720
gggaggaaat tcatggcgtt ccgtccccat tgttgtattc tttggagggc atagaagaca 780
tggtcgactg ggaaagaata atggatgttc gaagccagga tggctctttc ctaagctcac 840
ctgcttctat tgcgtgcgtc ttcatgcaca ctggagacat caaatgcctt gagttcttga 900
acaacgtgct cactaacttt ggtacttttg ttccctgctt gtatcctgtg gatctgctgg 960
aacgcctctt gatagtggat aatcttgtac aacttggaat cgatagacac tttgaaaagg 1020
aaatcaagga agctctcgat tatgttcaca ggcattggaa cgaaagagga attgggtggg 1080
gcagactgaa tcctatagca gatcttgaga tcactgcttt gggatttcga ctccttcggc 1140
tccatcggta caatgtatct ccagcggttt tcgagaactt caaagactca aatgggcact 1200
ttgtttgctc gggtgctcaa ttcaacaaag atgtagcaag catgctaagc ctttatagag 1260
cttcccagtt ggcatttccg ggagaaaata ttttggatga agctaaaagc ttcactagta 1320
aatatttaaa agaagctctt gagaaaagag agacttacag cgcgtggaac aacaaacaaa 1380
gcctaagcga agagattaaa tatgctctgg agaattcttg gcatgccagc gtcccgagag 1440
tggaagcaaa gagatattgt caagtgtatc gctcagacta tacatatcta gcaaaaagcg 1500
tttacaagct gccaaaggtg aacaacgaaa agattttaga gttggcaaaa ttggactttc 1560
aacattatcc aggccatcca ccaaaaagag atgaagaatg tcaccacctg gttaaaaatt 1620
cggagttccc tctattaccg ttcggtcggg agaggccggt ggagtgtttc ttcatagtag 1680
cggcaggcac gtatgagccc cagtatgcga aatgcagatt cctgttttca aaagtggcgt 1740
gcttgaatac tgttctggac gatatgtatg acacatatgg aacccttgat gaattgaagc 1800
tattcaccga ggctgtgaga agatgggacc tctccttgac agaaaacctt ccagactata 1860
tgaagctctg ctacaaaatc ttctacgaca tagttcacga agtggttttg gaggcagaga 1920
aggaacaggg acgcgaactg cttacttttt ttagaaaggg gtgggaggag tatctgatgg 1980
ggtattacga agaagcagaa tggttggcct gtgagtacct gccaagcttg gaggagtaca 2040
taaggaacgg gatcatttcc atcggacaac gaatacttgt ggtaagcggt gtgttattga 2100
tggagggcca aatcctttcg caagaggcgc tggaacagtt ggattatcca ggaagacgag 2160
tcctgacgga gttgaattcc atcattaccc ggctagcaga cgacatacat acatataagg 2220
cggagaaggc tcgtggagaa ttggcgtcga gcattgaatg ttatatgaga gaacatccgg 2280
gaagtacgga ggaagtggct gtgaattaca tgtacagcct tctggagccg gcagtgaagg 2340
agctgacctg ggagtttctg aagcccgagg acagtacagt ccacatccca ttccagtgca 2400
agaagatgct gatggaagag acgagagtga caatggtgat attcaaggaa ggagatgggt 2460
ttgggatctc aaaaacaaaa ataaaggatt acatcaaaga ctgtctaatt gaaccactgc 2520
ctctgtaa                                                          2528

<210> 642
<211> 2520
<212> DNA
<213> Pseudotsuga menziesii

<220> 
<223> (E)-gamma-bisabolene synthase

<400> 642
agtttgcgta gaagcagagc cattcaatca aaggattttt gtttgaaatt acatttcata 60
ctcttccttc aaatggcagc ttctactctt ccttccggtt tgtccactaa cgacttgatc 120
cgaaggacgg ccaatcctca tcctaatgtc tggggttatg atcttctatg ttctcttaaa 180
tcaccttact ctcgtgattc tagttacaaa gaacgtgcag acacacttat taatgagatt 240
aaggcgatgc ttggtgctgc gtttggagat ggaaaggaaa tgattactcc atctgcttat 300
gacacggcat gggtagcgag gataccctcc attgatggca gctctggctc tgctcgccct 360
caatttcctc aaacagttga ttggattttg aaaaaccagt tgaaagatgg ttcttgggga 420
actgagtcac actttttatt gtcagaaccc ctgctggcca ctatttcttg tgttcttgct 480
ctctttaaat ggcaagttgg ggatctgcaa gtagaacggg gcattgaatt cctaaagagc 540
agcctagaaa aaataaaaaa cgaaagcgat caagacagtt tggtaacaga ctttgagatc 600
atctttcctt ccatgttaag agaagctcag tctctccacc ttggacttcc gtacgacctg 660
ccttatatac agctgctgca gacgaaacgg caagagagat tagccaatct ctcaagggag 720
aaaattcatg gcggaatatt gcagctatca tctttggagg gcatagaaga tatggtcgag 780
tgggaaagat taatggatct tcaaagccta gatgggtctt tcttgagctc acctgcttct 840
accgctttcg ttttcataca cactggagac ctgaaatgtc tggcattctt gaacagcgtg 900
cttgctaagt ttggtgcttt tgttccatgc ctatatcatg tagatctgct ggaacgcctg 960
ttgatagtgg ataatattga acgccttgga atcgatagac actttgaaaa ggaaatcaat 1020
gaagctctag attatgttta caggtattgg tcgaacgaaa gaggaattgg gtggggcaga 1080
atgaatgcca ctgcagatct tgagaccact gctttgggat ttcgactgct tcgacttcat 1140
cgttatcatg tatctccagt cgttttcaag aaattcaaag atgctgatgg ggaattcttg 1200
agctcgatcg gtcaatttaa caaagatgta gcaagcatgc tgaaccttta tagagcttgc 1260
gagcttgcat ttcccggaga aaacattttg gatgaagcta aaggcttcac tgccaaatat 1320
ttgagagaag ctctggagaa aactgagact ttcagctcgt ggaacatcaa acgaaacctg 1380
agccaagaga ttaaatacgc actgaagact tcttggcatg ccagtatccc cagagtggaa 1440
gcaaagagat actgtcaagt gtatcgccca gattatgcac gcttagacaa aagcgtttac 1500
aagttgcacc acgtgaacaa cgaaaagatt ttggagctgg caaaattgga cttcaacatt 1560
atccagtcta tcctccaaga agagatgaag aatgtcacca gctggtttag agattcgggg 1620
ttgcctttgt tcagctttgc caggcagaga ccgctggaat tctacttctt gataacagcc 1680
gggacgtatg aaccccggta tgccaaatgc agattactct ttaccaaagt ggcgtgcgtg 1740
gaaactgttc tggacgatat gtatgacaca tatggaaccc ttgatgaatt aaagctattc 1800
actcaggctg tcagaagatg ggatccctcc cttacagaaa accttcctga ttacatgaaa 1860
cgttgctaca aaatctttta cgacatagtt cacgaagcgg cttgggaggc agaaaaggaa 1920
caggggcgtg aattggttag ctttttaaga aaggcatggg aggattttgt tttgagttat 1980
cacgaagaag ctgaatggtt aagtgctgag tatgtgcctg gcttcgacga gtacataaag 2040
aatgggatca cttccattgg ccaacgtgta cttttgctga gtggattgtt ggtgatggat 2100
gggcaactcc tttcgcaaaa ggcgttggag aaaatagatt atccagaaag atcacgtgtc 2160
ctcatggagc agatatgtct catttctcgg ctggcggatg acacacagtc atacaaggct 2220
gagaaggctc gtggagaatt ggcttccggc attgaatgtt acatgaaaga ccatcctgaa 2280
tgtacagagg aagaggccct gaatcacatc tatggcatta tggaggtgac agcgaaagag 2340
ttgacgaagg agtatctgaa ggtagacgac gacgacgtcc cattcgcgtg taagaagatg 2400
ctttttgaag agacgagagt gacgatggtg atattcaagg atggagaccg gttgagcaat 2460
tccaaattgg aaatgaagga tcatttcaag gagtgtctta ttgaaccact tcctctctaa 2520


<210> 643
<211> 1653
<212> DNA
<213> Ricinus communis

<220> 
<223> (+)-delta-cadinene synthase isozyme A

<400> 643
atgtcggctc aaactttggc aatttcgaat ttaaaaccca atactactcg tcacttggcg 60
agttttcatc cgaatatttg gggagatcgc tttctttcat gtgctgctga atccacggat 120
attgaggatg atatggagca acaagttgag agattaaagg aggaagtgaa aaagatgatt 180
gcttctgctg atgaaccctc acaaattctc aatctgattg atcttctcca acgattaggt 240
gtgtcttacc attttgaaaa agagattgag gaagcattgc agcaagtgtt gaatatgaac 300
agtgattctg acaaggatga tgaccttcat agtgtcgctc tccgatttcg attacttaga 360
gaacaaggcc tcaatgtctc ttgtgatgtt tttaacaagt tcagggatcg aaatgggcac 420
ttcattcaga cgctcaagac tgatctccag ggaatgttga gcttgtatga agctgcacat 480
ttcagagtcc atggagaagg catccttgac gacgcacttg ctttcactac cacttatctg 540
gagtccatag tccccaattt aagccctcct cttgcagccc aaatcagtcg caccttaagg 600
caaccgctga gaaagagctt ggcgagagtg gaggcaagac attttatctc catttaccaa 660
gaagatactt cccacaatga agtactacta acctttgcaa agttggactt caacctgttg 720
cagaaactgc accagaagga gctaaaatat atctcattgt ggtggaaaga tttagatttt 780
gtaaacaagc tcccttttac acgagacagg gtcgtggagg gttacttttg gatattggga 840
gtgtattttg agcctcagta ccatcgtgcc agaaagtttg taactaaagt aatcaatgta 900
gtatcagtaa tagatgatat atatgacgcg tacggcacac tggaagaact tgtagtcttt 960
actgatgcaa ttaacaggtg ggatattgat tgcatagacc aactccccga gtacatgaaa 1020
gtgtgctaca aagcactctt aaatgtgtat gaagaaatcg aaagggcatt atcagagcaa 1080
ggaagatctt accgccttca ttatgccaaa gaagcaatga agaagcttgt ccaagcatac 1140
ttggttgaag ccaattggat gaacaaaaat tatgtaccaa caatggatga gtatatgagc 1200
attgctttgg tatcttgtgc ctaccctctg cttacagtta catcttttgt tggcatgggt 1260
gatattgcaa caaaggaggt ctttgactgg gcttctaatg accctaaaat tgtgagagtt 1320
gcatctatca tttgtaggtt gatggatgac attgtatccc atgagttcga gcagaaaaga 1380
gggcatattg catctagtgt tgagtgctat atgaagcaaa atggtgtctc agaggaagca 1440
acaagagatg aattcaataa acaaatagtt gatgcttgga aggatataaa tgaggaacat 1500
cttcaaccaa attatgtacc aatgcctttc cgtacacgtg tggttaattc tgctcgtatt 1560
atggattact tatacaagga tgatgatgaa tacacacatg taggagaatt aatgaaaggt 1620
tccgttgcgg ctctattgat tgatccagca tag                              1653

<210> 644
<211> 1185
<212> DNA
<213> Ricinus communis

<220> 
<223> (+)-delta-cadinene synthase isozyme A

<400> 644
atgggaaaga gagataagaa acagaggcat cataatcaac acagaagcag agtagcttct 60
tactacaaca cagaacaaga agatgatggt tatagctatt cacagtcttc cttacctaat 120
gaagactcag acgcagaacc tgatgatgtt gaagaagaag aagaagaaga agaagagaaa 180
gaggacacta gtgatgcaaa agcatctaat gacgttcctt caaagtttct tctttaccaa 240
caatctgtac agtcgcccaa aggagatata agctatttgc aaaagttctt tttactgtat 300
gttggtggga ggttgcctct tcatttccag gaagatttct gcgggactgc tcttttaagt 360
acagaatggc tacgtagtga ctcaagacgg actgctgtag gagtggattt agaccttgag 420
gcactaaatt ggtgcatggc gaacaatgta aataaaattg gggctgatgg atattccaga 480
atatccctct ttcatggtaa tgtcttgcaa ccttctgatg ctgaattagt caggtttgag 540
ccccaagatc tgataagtaa catcaaattg ggagagcagg gagacaattc tgagaatact 600
gcactggaat ctgctctcca agtgggttca tcagcttctg ttagtgataa gtacttgaaa 660
agaaactttc agttaccagc aagagacatt gtgtgtgcct ttaactacag ctgctgttgt 720
ctccataaac gagcagatct ggttttatat ttcaaacatg ttcttgatgc cttgtccaaa 780
aagggtggtt tatttgtgat ggatttatat ggtggaacat catcagaagg caagctaagg 840
cttcagagaa gatttccaaa ttttacgtat atctgggagc aagctgaatt taacataatt 900
gagcgcaaaa caaggatcag cctccacttt catcttcaga agcagcagaa gaagcttcgc 960
catgcatttt catacagctg gaggctgtgg tcattgccag agatcagaga ctgcttagaa 1020
gaggctggat ttaaatccat tcacttctgg cttcggagga tgccagacag caaagacaac 1080
aggagcgtag agggattcgg gttcgggcga gacataaagt acgaggaggt caaaactttt 1140
gaacaagaag attcttggaa tgcatacatt gtagctgttg catag                 1185

<210> 645

<220> 
<223> Casbene synthase

<400> 645
 000

<210> 646
<211> 1994
<212> DNA
<213> Ricinus communis

<220> 
<223> casbene synthase, chloroplastic

<400> 646
actcagcagc cgcctctcct accccaatta gcacagaaga tttggtggtt cctctccttg 60
tgaaacatgg cattgccatc agctgctatg caatccaacc ctgaaaagct taacttattt 120
cacagattgt caagcttacc caccactagc ttggaatatg gcaataatcg cttccctttc 180
ttttcctcat ctgccaagtc acactttaaa aaaccaactc aagcatgttt atcctcaaca 240
acccaccaag aagttcgtcc attagcatac tttcctccta ctgtctgggg caatcgcttt 300
gcttccttga ccttcaatcc atcggaattt gaatcgtatg atgaacgggt aattgtgctg 360
aagaaaaaag ttaaggacat attaatttca tctacaagtg attcagtgga gaccgttatt 420
ttaatcgact tattatgtcg gcttggcgta tcatatcact ttgaaaatga tattgaagag 480
ctactaagta aaatcttcaa ctcccagcct gaccttgtcg atgaaaaaga atgtgatctc 540
tacactgcgg caattgtatt ccgagttttc agacagcatg gttttaaaat gtcttcggat 600
gtgtttagca aattcaagga cagtgatggt aagttcaagg aatccctacg gggtgatgct 660
aagggtatgc tcagcctttt tgaagcttcc catctaagtg tgcatggaga agacattctt 720
gaagaagcct ttgctttcac caaggattac ttacagtcct ctgcagttga gttattccct 780
aatctcaaaa ggcatataac gaacgcccta gagcagcctt tccacagtgg cgtgccgagg 840
ctagaggcca ggaaattcat cgatctatac gaagctgata ttgaatgccg gaatgaaact 900
ctgctcgagt ttgcaaagtt ggattataat agagttcagt tattgcacca acaagagctg 960
tgccagttct caaagtggtg gaaagacctg aatcttgctt cggatattcc ttatgcaaga 1020
gacagaatgg cagagatttt cttttgggca gtcgcgatgt actttgagcc tgactatgca 1080
cacacccgaa tgattattgc gaaggttgta ttgcttatat cactaataga tgatacaatt 1140
gatgcgtatg caacaatgga ggaaactcat attcttgctg aagcagtcgc aaggtgggac 1200
atgagctgcc tcgagaagct gccagattac atgaaagtta tttataaact attgctaaac 1260
accttctctg aattcgagaa agaattgacg gcggaaggca agtcctacag cgtcaaatac 1320
ggaagggaag cgtttcaaga actagtgaga ggttactacc tggaggctgt atggcgcgac 1380
gagggtaaaa taccatcgtt cgatgactac ttgtataatg gatccatgac caccggattg 1440
cctctcgtct caacagcttc tttcatggga gttcaagaaa ttacaggtct caacgaattc 1500
caatggctgg aaactaatcc caaattaagt tatgcttccg gtgcattcat ccgacttgtc 1560
aacgacttaa cttctcatgt gactgaacaa caaagaggac acgttgcatc ttgcatcgac 1620
tgctatatga accaacatgg agtttccaaa gacgaagcag tcaaaatact tcaaaaaatg 1680
gctacagatt gttggaaaga aattaatgaa gaatgtatga ggcagagtca agtgtcagtg 1740
ggtcacctaa tgagaatagt taatctggca cgtcttacgg atgtgagtta caagtatgga 1800
gacggttaca ctgattccca gcaattgaaa caatttgtta agggattgtt cgttgatcca 1860
atttctattt gaactcaata attccttttt tcattttgta cttcaataag ttataaatga 1920
cccgtgcact agcggtggtg attattgtat ttaaattgcc ttttaaatta atatatgaat 1980
caagaatttt atag                                                   1994

<210> 647
<211> 2358
<212> DNA
<213> Salvea sclarea

<220> 
<223> abdenediol diphosphate synthase

<400> 647
atgacttctg taaatttgag cagagcacca gcagcgatta cccggcgcag gctgcagcta 60
cagccggaat ttcatgccga gtgttcatgg ctgaaaagca gcagcaaaca cgcgcccttg 120
accttgagtt gccaaatccg tcctaagcaa ctctcccaaa tagctgaatt gagagtaaca 180
agcctggatg cgtcgcaagc gagtgaaaaa gacatttccc ttgttcaaac tccgcataag 240
gttgaggtta atgaaaagat cgaggagtca atcgagtacg tccaaaatct gttgatgacg 300
tcgggcgacg ggcgaataag cgtgtcaccc tatgacacgg cagtgatcgc cctgatcaag 360
gacttgaaag ggcgcgacgc cccgcagttt ccgtcatgtc tcgagtggat cgcgcaccac 420
caactggctg atggctcatg gggcgacgaa ttcttctgta tttatgatcg gattctaaat 480
acattggcat gtgtcgtagc cttgaaatca tggaaccttc actctgatat tattgaaaaa 540
ggagtgacgt acatcaagga gaatgtgcat aaacttaaag gtgcaaatgt tgagcacagg 600
acagcggggt tcgaacttgt ggttcctact tttatgcaaa tggccacaga tttgggcatc 660
caagatctgc cctatgatca tcccctcatc aaggagattg ctgacacaaa acaacaaaga 720
ttgaaagaga tacccaagga tttggtttac caaatgccaa cgaatttact gtacagttta 780
gaagggttag gagatttgga gtgggaaagg ctactgaaac tgcagtcggg caatggctcc 840
ttcctcactt cgccgtcgtc caccgccgcc gtcttgatgc ataccaaaga tgaaaaatgt 900
ttgaaataca tcgaaaacgc cctcaagaat tgcgacggag gagcaccaca tacttatcca 960
gtcgatatct tctcaagact ttgggcaatc gataggctac aacgcctagg aatttctcgt 1020
ttcttccagc acgagatcaa gtatttctta gatcacatcg aaagcgtttg ggaggagacc 1080
ggagttttca gtggaagata tacgaaattt agcgatattg atgacacgtc catgggcgtt 1140
aggcttctca aaatgcacgg atacgacgtc gatccaaatg tactaaaaca tttcaagcaa 1200
caagatggta aattttcctg ctacattggt caatcggtcg agtctgcatc tccaatgtac 1260
aatctttata gggctgctca actaagattt ccaggagaag aagttcttga agaagccact 1320
aaatttgcct ttaacttctt gcaagaaatg ctagtcaaag atcgacttca agaaagatgg 1380
gtgatatccg accacttatt tgatgagata aagctggggt tgaagatgcc atggtacgcc 1440
actctacccc gagtcgaggc tgcatattat ctagaccatt atgctggttc tggtgatgta 1500
tggattggca agagtttcta caggatgcca gaaatcagca atgatacata caaggagctt 1560
gcgatattgg atttcaacag atgccaaaca caacatcagt tggagtggat ccacatgcag 1620
gaatggtacg acagatgcag ccttagcgaa ttcgggataa gcaaaagaga gttgcttcgc 1680
tcttactttc tggccgcagc aaccatattc gaaccggaga gaactcaaga gaggcttctg 1740
tgggccaaaa ccagaattct ttctaagatg atcacttcat ttgtcaacat tagtggaaca 1800
acactatctt tggactacaa tttcaatggc ctcgatgaaa taattagtag tgccaatgaa 1860
gatcaaggac tggctgggac tctgctggca accttccatc aacttctaga cggattcgat 1920
atatacactc tccatcaact caaacatgtt tggagccaat ggttcatgaa agtgcagcaa 1980
ggagagggaa gcggcgggga agacgcggtg ctcctagcga acacgctcaa catctgcgcc 2040
ggcctcaacg aagacgtgtt gtccaacaat gaatacacgg ctctgtccac cctcacaaat 2100
aaaatctgca atcgcctcgc ccaaattcaa gacaataaga ttctccaagt tgtggatggg 2160
agcataaagg ataaggagct agaacaggat atgcaggcgt tggtgaagtt agtgcttcaa 2220
gaaaatggcg gcgccgtaga cagaaacatc agacacacgt ttttgtcggt ttccaagact 2280
ttctactacg atgcctacca cgacgatgag acgaccgatc ttcatatctt caaagtactc 2340
tttcgaccgg ttgtatga                                               2358

<210> 648
<211> 2355
<212> DNA
<213> Salvea sclarea

<220> 
<223> labdenediol diphosphate synthase

<400> 648
atgacttctg taaatttgag cagagcacca gcagcgatta tccggcgcag gctgcagcta 60
cagccggaat ttcatgccga gtgttcatgg ctgaaaagca gcagcaaaca cgcgcccttc 120
accttgagtt gccaaatccg tcctaagcaa ctctcccaaa tagctgaatt gagagtaaca 180
agcctggatg cgtcgcaagc gagtgaaaaa gacatttccc ttgttcaaac tccgcataag 240
gttgaggtta atgaaaagat cgaggagtca atcgagtacg tccaaaatct gttgatgacg 300
tcgggcgacg ggcgaataag cgtgtcaccc tatgacacgg cagtgatcgc cctgatcaag 360
gacttgaaag ggcgcgacgc cccgcagttt ccgtcatgtc tcgagtggat cgcgcaccac 420
caactggctg atggctcatg gggcgacgaa ttcttctgta tttatgatcg gattctaaat 480
acattggcat gtgtcgtagc cttgaaatca tggaaccttc aatctgatat tattgaaaaa 540
ggtgtgacgt acatcaagga gaatgtgcat aaacttaaag gtgcaaatgt tgagcacagg 600
acagcggggt tcgaacttgt ggttcctact tttatgcaaa tggccacaga tttgggcatc 660
caaggtctgc cctatgatca tcccctcatc aaggagattg ctgacacaaa acaacaaaga 720
ttgaaagaga tacccaagga tttggtttac caaatgccaa cgaatttact gtacagttta 780
gaagggttag gagatttgga gtgggaaagg ttactgaaac tgcagtcggg caatggctcc 840
ttcctcactt cgccgtcgtc caccgccgcc gtcttgatgc ataccaaaga tgaaaaatgt 900
ttgaaataca tcgaaaacgc cctcaagaat tgcgacggag gagcaccaca tacttatcca 960
gtcgatatct tctcaagact ttgggcaatc gataggctac aacgcctagg aatttctcgt 1020
ttcttccagc acgagatcaa gtatttctta gatcacatcg aaagcgtttg ggaggagacc 1080
ggagttttca gtggaagata tacgaaattt agcgatattg atgacacgtc catgggcgtt 1140
aggcttctca aaatgcacgg atacgacgtc gatccaaatg tactaaaaca tttcaagcaa 1200
caagatggta aattttcctg ctacattggt caatcggtcg agtctgcatc tccaatgtac 1260
aatctttata gggctgctca actaagattt ccaggagaag aagttcttga agaagccact 1320
aaatttgcct ttaacttctt gcaagaaatg ctagtcaaag atcgacttca agaaagatgg 1380
gtgatatccg accacttatt tgatgagata aagctggggt tgaagatgcc atggtacgcc 1440
actctacccc gagtcgaggc tgcatattat ctagaccatt atgctggttc tggtgatgta 1500
tggattggca agagtttcta caggatgcca gaaatcagca atgatacata caaggagctt 1560
gcgatattgg atttcaacag atgccaaaca caacatcagt tggagtggat ccagatgcag 1620
gaatggtacg acagatgcag ccttagcgaa ttcgggataa gcaaaagaga gttgcttcgc 1680
tcttactttc tggccgcagc aaccatattc gaaccggaga gaactcaaga gaggcttctg 1740
tgggccaaaa ccagaattct ttctaagatg atcacttcat ttgtcaacat tagtggaaca 1800
acactatctt tggactacaa tttcaatggc ctcgatgaaa taattagtgc caatgaagat 1860
caaggactgg ctgggactct gctggcaacc ttccatcaac ttctagacgg attcgatata 1920
tacactctcc atcaactcaa acatgtttgg agccaatggt tcatgaaagt gcagcaagga 1980
gagggaagcg gcggggaaga cgcggtgctc ctagcgaaca cgctcaacat ctgcgccggc 2040
ctcaacgaag acgtgttgtc caacaatgaa tacacggctc tgtccaccct cacaaataaa 2100
atctgcaatc gcctcgccca aattcaagac aataagattc tccaagttgt ggatgggagc 2160
ataaaggata aggagctaga acaggatatg caggcgttgg tgaagttagt gcttcaagaa 2220
aatggcggcg ccgtagacag aaacatcaga cacacgtttt tgtcggtttc caagactttc 2280
tactacgatg cctaccacga cgatgagacg accgatcttc atatcttcaa agtactcttt 2340
cgaccggttg tatga                                                  2355

<210> 649
<211> 1728
<212> DNA
<213> Salvea sclarea

<220> 
<223> sclareol synthase

<400> 649
atgtcgctcg ccttcaacgt cggagttacg cctttctccg gccaaagagt tgggagcagg 60
aaagaaaaat ttccagtcca aggatttcct gtgaccaccc ccaataggtc acgtctcatc 120
gttaactgca gccttactac aatagatttc atggcgaaaa tgaaagagaa tttcaagagg 180
gaagacgata aatttccaac gacaacgact cttcgatccg aagatatacc ctctaatttg 240
tgtataatcg acacccttca aaggttgggg gtcgatcaat tcttccaata tgaaatcaac 300
actattctag ataacacatt caggttgtgg caagaaaaac acaaagttat atatggcaat 360
gttactactc atgcaatggc atttaggctt ttgcgagtga aaggatacga agtttcatca 420
gaggagttgg ctccatatgg taaccaagag gctgttagcc agcaaacaaa tgacctgccg 480
atgattattg agctttatag agcagcaaat gagagaatat atgaagaaga gaggagtctt 540
gaaaaaattc ttgcttggac taccatcttt ctcaataagc aagtgcaaga taactcaatt 600
cccgacaaaa aactgcacaa actggtggaa ttctacttga ggaattacaa aggcataacc 660
ataagattgg gagctagacg aaacctcgag ctatatgaca tgacctacta tcaagctctg 720
aaatctacaa acaggttctc taatttatgc aacgaagatt ttctagtttt cgcaaagcaa 780
gatttcgata tacatgaagc ccagaaccag aaaggacttc aacaactgca aaggtggtat 840
gcagattgta ggttggacac cttaaacttt ggaagagatg tagttattat tgctaattat 900
ttggcttcat taattattgg tgatcatgcg tttgactatg ttcgtctcgc atttgccaaa 960
acatctgtgc ttgtaacaat tatggatgat tttttcgact gtcatggctc tagtcaagag 1020
tgtgacaaga tcattgaatt agtaaaagaa tggaaggaga atccggatgc agagtacgga 1080
tctgaggagc ttgagatcct ttttatggcg ttgtacaata cagtaaatga gttggcggag 1140
agggctcgtg ttgaacaggg gcgtagtgtc aaagagtttc tagtcaaact gtgggttgaa 1200
atactctcag ctttcaagat agaattagat acatggagca atggcacgca gcaaagcttc 1260
gatgaataca tttcttcgtc gtggttgtcg aacggttccc ggctgacagg tctcctgacg 1320
atgcaattcg tcggagtaaa attgtccgat gaaatgctta tgagtgaaga gtgcactgat 1380
ttggctaggc atgtctgtat ggtcggccgg ctgctcaacg acgtgtgcag ttctgagagg 1440
gagcgcgagg aaaatattgc aggaaaaagt tatagcattc tactagcaac tgagaaagat 1500
ggaagaaaag ttagtgaaga tgaagccatt gcagagatca atgaaatggt tgaatatcac 1560
tggagaaaag tgttgcagat tgtgtataaa aaagaaagca ttttgccaag aagatgcaaa 1620
gatgtatttt tggagatggc taagggtacg ttttatgctt atgggatcaa cgatgaattg 1680
acttctcctc agcaatccaa ggaagatatg aaatcctttg tcttttga              1728

<210> 650
<211> 1656
<212> DNA
<213> Santalum album

<220> 
<223> santalene synthase

<400> 650
atgtcaactc aacaagtttc atcagagaac attgttcgta acgctgcgaa tttccatcct 60
aatatatggg gaaaccattt cctcacatgt ccttctcaga cgattgatag ttggactcaa 120
cagcaccaca aagaactgaa agaagaggtg aggaaaatga tggtgtctga tgcaaataaa 180
cctgcccaga gattgcgctt gattgatact gtccaaaggc taggtgtggc ttaccacttt 240
gaaaaggaga ttgatgatgc attggagaaa ataggtcatg acccttttga tgataaagat 300
gatctctaca ttgtctctct ttgttttcga ttgctgaggc agcatggaat taagatatca 360
tgtgatgtgt ttgagaagtt taaagatgac gatggaaaat tcaaggcatc attgatgaat 420
gatgttcaag gcatgctaag tttatatgag gcagcacacc tagccattca cggagaagat 480
attttagatg aagcaattgt tttcacgacc actcacctta agtcaacggt atctaattct 540
cctgtaaact ctacttttgc tgaacaaata cgtcattctc tcagagttcc tctccgtaaa 600
gctgtaccta ggttagagtc gaggtatttc ttggatatct attcaagaga tgatttgcac 660
gataaaactt tgctcaattt cgcaaagtta gactttaata tactacaagc aatgcaccag 720
aaggaagcaa gtgagatgac caggtggtgg agagattttg acttccttaa aaagctgcct 780
tatataagag acagagtcgt ggagctatat ttttggattc tggtgggagt gtcttatcag 840
cccaaattca gcactggtag aatttttttg tccaaaataa tatgccttga gaccctcgta 900
gatgatacat ttgacgccta cggtactttt gacgagctcg caatctttac tgaagcagtt 960
acaagatggg accttggcca cagagatgca ctaccagaat acatgaaatt cattttcaag 1020
acactcattg atgtctacag tgaagctgag caagaactgg caaaggaagg gagatcatac 1080
agcatacact atgcaatacg atcgttccaa gaactagtta tgaagtactt ctgcgaagcc 1140
aagtggttaa ataaaggtta tgttccgagc ctggacgatt ataaatcagt ttcattaaga 1200
agtatcggtt ttttaccgat agcggtagct tccttcgttt tcatgggtga tattgcaact 1260
aaggaggtct ttgaatggga aatgaataac cctaagatca taatagccgc agaaacgatt 1320
ttcagattcc tggatgacat agcaggccat aggtttgagc aaaagagaga acatagtcca 1380
tcagctattg aatgctacaa gaatcaacat ggagtgtctg aggaagaggc agttaaagcg 1440
ttgtcgttag aagttgctaa tagttggaaa gatataaatg aggagctgct tctcaaccca 1500
atggctattc ctttacctct gcttcaggtg attcttgatc tctcacgttc ggccgatttt 1560
atgtacggta atgctcaaga tcgcttcacg cattcaacga tgatgaaaga ccaagttgat 1620
ttggtgctga aggaccccgt taagcttgac gattaa                           1656

<210> 651
<211> 1650
<212> DNA
<213> Santalum album

<220> 
<223> santalene synthase

<400> 651
atggctaccg ataatgacag ctctgaaaac cgtcgtatgg gtaattacaa gccgtccatc 60
tggaactacg acttcctgca gtccctggct acccgccaca atatcatgga agagcgccac 120
ttgaaactgg cggagaaact gaaaggccag gtgaagttta tgtttggtgc cccgatggag 180
ccgctggcca aactggagct ggttgatgtt gttcagcgcc tgggtctgaa tcatcgcttc 240
gagacggaga ttaaggaggc cctgttcagc atctacaagg atgagagcaa cggttggtgg 300
tttggccacc tgcatgccac cagcctgcgt tttcgcctgc tgcgccagtg tggtctgttc 360
attccgcaag acgttttcaa gacgttccaa agcaagaccg gcgagttcga catgaaactg 420
tgcgacaacg tcaagggttt gctgagcctg tacgaggctt cctttctggg ctggcgtgac 480
gaaaatatcc tggacgaagc gaaagctttt gccacgaagt acctgaagaa cgcatgggaa 540
aacattagcc agaagtggct ggcgaaacgc gtgaagcatg cgttggcact gccgttgcac 600
tggcgtgtgc ctcgtattga agcacgctgg tttgttgagg cgtacggcga ggaggaaaat 660
atgaatccga ccttgctgaa gctggctaag ttggatttta acatggtgca atctattcac 720
caaaaggaaa tcggtgaatt ggcacgttgg tgggtcacca ccggtctgga caaactggca 780
ttcgcgcgca ataatttgct gcaaagctac atgtggagct gcgcgatcgc atctgacccg 840
aagtttaagc tggctcgcga aaccatcgtg gagatcggtt ccgtgctgac tgttgtggat 900
gacgcctacg atgtttacgg tagcatggac gaactggact tgtataccaa tagcgtggag 960
cgttggagct gtacggaaat cgataagctg ccgaatacgc tgaaactgat ttttatggct 1020
atgtttaaca agaccaatga agttggtctg cgtgttcagc acgagcgtgg ttactccggc 1080
atcaccacct tcattaaggc atgggtcgaa cagtgtaaga gctatcaaaa agaagcgcgc 1140
tggtatcatg gtggtcacac gcctccgctg gaagagtact ccttgaatgg cttggtgagc 1200
attggtttcc cgctgctgct gattaccggc tacgtcgcca ttgccgaaaa cgaagcagcg 1260
ctggacaaag tgcatccgct gccggatctg ctgcactata gctctctgct gagccgcctg 1320
atcaacgaca tgggtacgag cagcgacgag ctggagcgcg gcgataatct gaaaagcatc 1380
caatgctata tgaatcagac cggcgcgagc gagaaggtgg cgcgcgagca catcaagggc 1440
atcattgagg agaattggaa gattctgaac gaatgttgct tcgaccaaag ccaatttcaa 1500
gagccgttcg tgacgttcaa cctgaacagc gttcgtggtt cccatttctt ttacgagttt 1560
ggtgacggtt tcggtgtgac gaatagctgg accaaggttg acatgaagag cgtcctgatt 1620
gatccgattc cactggatga agaataatga                                  1650

<210> 652
<211> 1656
<212> DNA
<213> Santalum album

<220> 
<223> santalene synthase

<400> 652
atggcaacct tgaagactga caccgacgct agcgagaatc gtcgcatggg caactataaa 60
ccgagcattt ggaactacga tttcctgcaa agcctggcta cccaccacaa tatcgtggag 120
gagcgtcacc tgaaactggc agaaaaattg aaaggccaag tgaaattcat gttcggcgca 180
ccgatggaac cgctggcgaa actggagctg gtcgacgtgg tccaacgcct gggtctgaat 240
cacctgtttg aaaccgaaat taaagaggca ctgttcagca tctataagga cggttcgaac 300
ggttggtggt tcggtcacct gcatgcaacc agcctgcgtt ttcgtctgct gcgtcagtgt 360
ggcctgttca ttccgcagga cgtctttaaa acctttcaga acaaaaccgg cgagtttgac 420
atgaagctgt gggacaatgt gaaaggcctg ttgagcctgt atgaggcgag ctacctgggt 480
tggaagggtg aaaacatcct ggatgaagca aaggcattta ccaccaagtg tctgaagagc 540
gcgtgggaaa atatctctga gaaatggttg gcgaaacgtg tgaagcacgc gctggcgctg 600
ccgctgcact ggcgcgttcc gcgcatcgaa gcgcgctggt ttatcgaagt ttatgaacag 660
gaagctaata tgaacccgac cctgctgaag ctggcgaagc tggatttcaa catggttcaa 720
agcattcatc aaaaggagat cggcgagctg gcccgctggt gggtgaccac gggtttggac 780
aagctggact ttgcacgtaa taatctgttg caaagctaca tgtggagctg cgctatcgca 840
tccgacccga aatttaagtt ggcacgtgaa accatcgttg aaattggtag cgtgctgact 900
gtggtggatg acggttacga tgtttacggt agcatggacg aactggacct gtacacgtcg 960
agcgtcgagc gctggagctg tgtcaaaatt gataagctgc cgaacacgct gaaactgatc 1020
ttcatgagca tgttcaacaa aaccaacgaa gtgggcctgc gcgtgcagca cgaacgtggc 1080
tataatagca ttccgacgtt tatcaaggca tgggtggagc aatgtaaaag ctaccaaaaa 1140
gaggcccgtt ggtttcatgg cggccatacc ccgcctctgg aggaatatag cctgaacggc 1200
ctggtgtcca ttggttttcc gctgctgctg atcaccggct acgtggcaat cgcggaaaat 1260
gaagccgcgc tggacaaggt ccatccactg ccggacctgt tgcattatag ctctctgctg 1320
agccgtctga tcaatgatat cggtacgagc ccggacgaga tggctcgtgg tgacaacctg 1380
aaaagcatcc attgttatat gaacgagacg ggtgcgtccg aagaggtcgc ccgcgagcat 1440
atcaagggcg ttattgagga gaactggaaa atcctgaatc aatgttgctt cgatcaaagc 1500
cagttccaag agccgttcat cacgttcaat ctgaacagcg ttcgcggtag ccactttttc 1560
tacgaatttg gcgacggttt tggcgttacg gacagctgga ccaaagttga tatgaaatcc 1620
gttctgatcg acccgatccc gttgggtgaa gagtag                           1656

<210> 653
<211> 2157
<212> DNA
<213> Santalum album

<220> 
<223> santalene synthase

<400> 653
acaaaataaa tctcttgttc tgttctttgg atctcgtttt cttcccctca gctctctcac 60
taatggattc ttccaccgcc accgccatga gagctccatt cattgatcat actgatcatg 120
tgaatctcag aactgataac gattcctcag agaatcgaag gatggggaat tataaaccca 180
gtatttggaa ctatgatttt ttgcaatcgc ttgcgactcg ccacaatatt atggaagaga 240
ggcatctaaa gctagctgag aagctgaagg gccaagtgaa gtttatgttt ggggcaccaa 300
tggagccgtt agcaaagctg gagcttgtgg atgtggttca aaggctcggg ctaaaccacc 360
gatttgagac agagatcaag gaagcgctat ttagtattta taaggatgag agcaatggat 420
ggtggtttgg ccacctccat gcgacatctc tccgatttag gctgctacga cagtgtgggc 480
tttttatccc ccaggatgtg tttaaaacat ttcagagcaa aactggtgaa tttgatatga 540
aactgtgtga caatgtaaaa ggattgctga gcttgtatga agcttcattc ttggggtgga 600
gggatgaaaa catcttagat gaagccaaag ccttcgccac caagtacttg aaaaatgcat 660
gggaaaacat atcccaaaag tggcttgcca aaagagtgaa gcatgcactg gctttgcctt 720
tgcactggag agtccctaga atcgaagcta gatggttcgt tgaggcatat ggggaagaag 780
agaatatgaa cccaacactt ctcaaacttg caaaattgga ctttaacatg gtgcaatcaa 840
ttcatcagaa agagattggg gaattagcga ggtggtgggt gactacgggg ttggataagt 900
tagcgtttgc taggaataat ttactgcaaa gctatatgtg gagctgcgcg attgcttccg 960
acccaaagtt caaacttgct agagaaacta ttgttgaaat cggaagtgta ctcacagttg 1020
ttgacgatgc atatgacgtc tatggttcaa tggatgaact tgatctctac acgaactccg 1080
ttgaaaggtg gagctgtaca gaaattgaca agttaccaaa cacattaaaa ttgattttta 1140
tgtctatgtt taacaagacc aatgaagttg gccttcgagt ccagcatgag cgaggctaca 1200
gtggcatcac tacttttatc aaagcgtggg ttgaacagtg taaatcgtac cagaaagaag 1260
caagatggta ccatggggga cacacgcctc cactggaaga atatagcttg aatggactgg 1320
tttccatagg attccctctc ttgttgatca caggctacgt ggcaatcgct gagaacgagg 1380
ctgcactgga taaagtgcac ccccttcctg atcttctgca ctactcctcc ctccttagtc 1440
gcctcatcaa tgatatggga acctcttcgg acgagttgga aaggggagat aatctgaagt 1500
caattcaatg ttacatgaac caaactgggg cttctgagaa agttgctcgt gagcacataa 1560
agggaataat cgaggaaaac tggaaaatac tgaatgagtg ttgctttgat caatctcagt 1620
ttcaggagcc ttttgtaaca ttcaatttga actctgttcg agggtctcat ttcttctacg 1680
aatttggaga tggctttggg gtgacggata gctggacaaa ggttgatatg aagtctgttt 1740
tgatcgatcc tattcctctc gacgaggagt agaaaactca aagcttgtgc ttggtttacg 1800
gtaatagtga ttcagtataa atataaaaat cggacgaact tgaggaatat gtgaggcata 1860
actattttta atgatcatga gttaaataat taagaaatat ctattcggct catgattctt 1920
gagtatatat tattccttat gcgttatatt tccatcaaat aattagtccg ctcctgtaag 1980
tcgactgtaa cattactcta agggtcgcta ttggttttat gttatattaa gtctactagt 2040
ttgaagtgat ggaataaatg tttgttttta agggggttat gcactatgtt ctcggttgcc 2100
ttttactaat aaatttttta tgaaactcaa aaaaaaaaaa aaaaaaaaaa aaaaaaa    2157

<210> 654
<211> 1725
<212> DNA
<213> Santalum album

<220> 
<223> santalene synthase

<400> 654
actaatggat tcttccaccg ccaccgccat gacagctcca ttcattgatc ctactgatca 60
tgtgaatctc aaaactgata ctgatgcctc agagaatcga aggatgggaa attataaacc 120
cagcatttgg aattatgatt ttttacaatc acttgcaact catcacaata ttgtggaaga 180
gaggcatcta aagctagctg agaagctgaa gggccaagtg aagtttatgt ttggggcacc 240
aatggagccg ttagcaaagc tggagcttgt ggatgtggtt caaaggcttg ggctaaacca 300
cctatttgag acagagatca aggaagcgct gtttagtatt tacaaggatg ggagcaatgg 360
atggtggttt ggccaccttc atgcgacatc tctccgattt aggctgctac gacagtgtgg 420
gctttttatt ccccaagatg tgtttaaaac gttccaaaac aaaactgggg aatttgatat 480
gaaactgtgg gacaacgtaa aagggctgct gagcttatat gaagcttcat acttgggatg 540
gaagggtgaa aacatcctag atgaagccaa ggccttcacc accaagtgct tgaaaagtgc 600
atgggaaaat atatccgaaa agtggttagc caaaagagtg aagcatgcat tggctttgcc 660
tttgcattgg agagtccctc gaatcgaagc tagatggttc attgaggtat atgagcaaga 720
agcgaatatg aacccaacac tactcaaact cgcaaaatta gactttaata tggtgcaatc 780
aattcatcag aaagagattg gggaattagc aaggtggtgg gtgactactg gcttggataa 840
gttagacttt gctaggaata atttactgca gagctatatg tggagctgcc cgattgcttc 900
cgacccgaag ttcaaacttg ctagagaaac tattgtcgaa atcggaagtg tactcacagt 960
tgttgacgat ggatatgacg tctatggttc aatggacgaa cttgatctct acacaagctc 1020
cgttgaaagg tggagctgtg tgaaaattga caagttgcca aacacgttaa aattaatttt 1080
tatgtctatg ttcaacaaga ccaatgaggt tggtcttcga gtccagcatg agcgaggcta 1140
caatagcatc cctactttta tcaaagcgtg ggttgaacag tgtaaatcat accagaaaga 1200
agcaagatgg ttccacgggg gacacacgcc tccattggaa gaatatagct tgaatggact 1260
tgtttccata ggattccctc tcttgttaat cacaggctac gtggcaatcg ctgagaacga 1320
ggctgcactg gataaagtgc acccccttcc tgatcttctg cactactcct ccctccttag 1380
tcgcctcatc aatgatatag gaacgtctcc ggatgagatg gcaagaggcg ataatctgaa 1440
gtcaatccat tgttacatga acgaaactgg ggcttccgag gaagttgctc gtgagcacat 1500
aaagggagta atcgaggaga attggaaaat actgaatcag tgctgctttg atcaatctca 1560
gtttcaggag ccttttataa ccttcaattt gaactctgtt cgagggtctc atttcttcta 1620
tgaatttggg gatggctttg gggtgacgga tagctggaca aaggttgata tgaagtccgt 1680
tttgatcgac cctattcctc tcggcgagga gtagtaagct cgaag                 1725

<210> 655
<211> 1680
<212> DNA
<213> Santalum album

<220> 
<223> sesquiterpene synthase

<400> 655
atggaaaatc aaaaagtgcc tatttcttct gtccccaacc tcaaggaact ttctcgcccc 60
attgctaatt ttccccccag catttggggt gaccgtttca tcaactacgc ctgtgaagat 120
gagaatgagc aagcacagaa agagagacaa gttgaagagt taaaagagca ggtaaggagg 180
gagttagctg ctaccgtcga taagcccttg cagcagctaa atatcatcga tgcaactcaa 240
cggctgggaa ttgcatacca cttcgaaaat gagattgaag aatcactcga acatatctac 300
ctccacacct atgtggagaa taattgtttt cagggctccc acgatcttta tagtgttgct 360
ctttggtttc gtctcctaag acaagatggt tacaaggttt catgcgatgt attcgacaag 420
tttagagact atgaggataa cttcaaaaat agcttaatgg aagacgcaaa aggcctatta 480
gaattgtatg aagcaactca cctaagcgtg catggagaag agatgctaga tgatgctcta 540
gagtttgcta agactcgcct cgagtcaatt gtaaatcatt tgaattaccc tctagctgaa 600
caagttcgcc atgccctata tcggccacta cgcaaaggct tgcctagact agaggctgta 660
tacttctttc ggatctatga agcatatgat tcccataaca aagctttatt gaagctggca 720
aaacttgatt tcaacttact tcagtctttg cacaagaaag agctcagtga catggctaga 780
tggtggaagt ctttggattt tgctgcaaaa tttccttttg caagggacag actagttgag 840
ggttattttt gggtactggg ggtgtacttt gagccacagt actcccttgc acggaaaatt 900
ataatcaaag tattcactat gatttctact atcgatgaca tttatgatgc atacggtaca 960
ttagatgagt tagagctatt tactaaagca atgcaaaggt gggatgttgg gagcttggat 1020
cagcttccag agtatatgaa accctgctat aaatcaattt tggatgttta caatgaaatt 1080
gaggaagaga tggacaatca aggaagcctg tttcggatgc actacgctaa agaagtgatg 1140
aagaaattag tggaaggcta tatggatgaa gccaaatggt gccatgagaa atatgtgccc 1200
acgttcgaag aatacatgcc cgtcgcactg gtgacatctg gctacacatt tctcacgact 1260
atatcatacc ttggaatggg cgagattgcg tcgaaggaag catttgattg gctttttagt 1320
cacccacccg ttatagaagc ttcggaatct gtttgtaggc ttatggatga tatgagatcc 1380
cacaagtttg agcaagagag aggacatgtt gcatcaggta tagaatgtta catgaagcag 1440
tatggtgtta cagaagaaga ggctcatgat gaatttcgta agcaattggt gaaagcttgg 1500
aaggacataa atgaagagtg cctaaggcca tatcgtgtgc cgaaacctct tttgatgcgc 1560
attctcaacc ttacacgagt gatagatgtt atttacaaga acgaagacgg ctacacacat 1620
gtgaagaagg ccatgaaaga taacattgca tccctactta tagatcccat gattgtttga 1680


<210> 656
<211> 1855
<212> DNA
<213> Santalum austrocaledonicum

<220> 
<223> sesquiterpene synthase

<400> 656
acacagctcc cgtctatgct ttgaagcact ccaaacatca tactgaactt ttcatttgcc 60
ctcatggaaa atcaaaaagt gcctatttct tctgtcccca acctcaagga actttctcgc 120
cccattgcta atttccctcc cagcatttgg ggtgaccgtt tcatcaacta cacctgtgaa 180
gatgagaatg agcaagccca gaaagagaga caagttgaag aattaaagga gcaggtgagg 240
agggagttag ctgctaccgt cgataagccc ttgcagcagc taaatatcat cgatgcaact 300
caacggctgg gaatcgcata ccacttcgaa aatgagattg aagaatcact cgaacatatc 360
tacctccaca cctatgtgaa gaataattgt tttcagggct cccacgatct ttacagtgtt 420
gctctttggt ttcgtctact aagacaagat ggttacaagg tttcatgcga tgtattcgac 480
aattttagag actatgaggg taacttcaaa aacagcttaa tggaagacgc aaaaggccta 540
ttagaattgt atgaagcaac tcacctaagc gtgcatggag aagagatgct agatgatgct 600
ctagagtttg ctaagactcg cctcgagtca attgtaaatc atttgaatta ccctctagct 660
gaacaagttc gccatgccct ataccggcca ctacgcaaag gcttgcctag actagaggct 720
gtatacttct ttcggatcta tgaagcatat cattcccata acaaagcttt attgaagctg 780
gcaaaacttg atttcaactt acttcagtct ttgcacagga aagagctcgg tgacatggct 840
agatggtgga ggtctttgga tttcgctaca aaatttcctt ttgcaagaga tagactagtt 900
gagggttatt tttggatatt gggggtttac tttgagccac agtactccct tgcacgggaa 960
attacaacca aagtattcgc tatgatttcc actatcgatg atatttatga tgcatatggc 1020
acattagatg agttaaagct atttactgaa gcaatccaaa ggtgggatgt tgggagcttg 1080
gatcagcttc cagagtatat gaaaccctgc tataaatcaa ttttggatgt ttacaatgaa 1140
attgaggaag agatggccaa tcaaggaagc ctgtttcgga tgcactacgc taaagaagtg 1200
atgaagacaa tagtcgaagg ctatatggat gaagccaaat ggtgccatga gaaatatgtg 1260
cccacgttcc aagagtacat gtcccttgca ctggtgacat ctggctacac atttctcacg 1320
actatatcgt accttggcat gggcggaatt gcctcgaagg aagcatttga atggcttttt 1380
agtcacccac ccattattga agcttcggaa tctatttgta ggcttatgga tgatatgagc 1440
tcccacaagt ttgaacaaga gagaggacat gttgcatcgg gtatagagtg ttacatgaag 1500
caatatggtg ttatagagga agaagcacat gatgaatttc ataagcgatt ggtgaaagca 1560
tggaaggaca taaacgaagg gttcctaagg ccgtatgccg tgccggaacc tcttttgatg 1620
cgcatcctca accttacacg agtgatggat gttatttaca agaatgaaga cagctacacg 1680
catgtgaaga aggccatgaa agataacatc gcatccctac ttatagatcc catgattgtt 1740
tgaatgcatc cgttggattt accgttatat aatgtaagtg aaatgccagt ttgtggttat 1800
taaaataaag agtaatagat tttcgttgat aaaaaaaaaa aaaaaaaaaa aaaaa      1855

<210> 657
<211> 1689
<212> DNA
<213> Santalum spicatum

<220> 
<223> sesquiterpene synthase

<400> 657
atggaaaatc aaaaagtgcc tatttcttct gtccccaacc tcaaggacct agatatgatt 60
tctcgcccca ttgccaattt cccccccagc gtttggggcg atcgtttcat caactacgcc 120
tgtgaagatg agaatgaaca agcccagaaa gaaagacaag ttgaagagct aaaggagcag 180
gtgaggaggg agctggctgc tgccatcgat aagccgttac agcagctgaa tatcatcgat 240
gcaactcaac ggctaggaat tgcttatcac ttcgaaaatg agatcgaaga atcacttaaa 300
catatctacc tccacaccta tgtggagaat acttgttttg agggctccga cgatctctgt 360
agtgttgctc tttggtttcg tctactaaga caagatggtt acagggtttc atgcgatgta 420
ttcaagaagt ttagagacag cgaaggtaac ttcaaaaaca gcttaatgga agacgcaaaa 480
ggcctgttag aattgtatga agcaactcac ttaagcgtta atggagaaga gatgctagat 540
gatgctctgg agtttactaa gactcacctc gagttagttg tgagccattt gaattatcct 600
ctagccgaac aagttcgcca tgccctatat cagccgcaac acaagggctt gcctagacta 660
gaggccgtat acttctttcg gatctatgaa gcttatgatt cccataacga agctttattg 720
aagctggcaa aacttgattt caacttactt cagtctttgc acatgaaaga gctcagtcac 780
atggctaaat ggtggaagtc tttggatttc gcaacaaaat ttccttttgc aagagacaga 840
ctagttgagg gttatttttg gatactgggg gtgtactttg agccacagta ctccctcgca 900
cggaaaatta taatcaaagt attcactatg atttctacta tcgatgacat ttatgatgca 960
tacggtacat tagatgagct aaagctattt actaaagcaa tccagaggtg ggatattggg 1020
agcttggatc agcttccaga gtatatgaaa ccctgctata aatcagtttt ggacgtttac 1080
aatgaaattg aggaagagat ggacaatcag ggaagcctgt ttcggatgca ctacgctaaa 1140
gaagagatga agaaaatagt ggaaggctat atggatgaag ccaaatggtg ccatgagaaa 1200
tatgtgccca cgttccaaga gtacatgtcc gtcgcactgg tgacagctgg ctacacattt 1260
ctcacgacaa tatcgtacct tggaatgggc gaaattgcgt cgaaggaagc atttgattgg 1320
ctttttagtc acccacccat tattgaagct tcagaatctg ttggtaggct tatggatgat 1380
atgagatccc acgagtttga gcaagagaga ggacatgttg catcgggtat agaatgttac 1440
atgaagcagt atggtgttac agaggaagag gcacatgata aatttcataa gcgattggtg 1500
aaagcttgga aggatatcaa cgaagggtgc ctaaggccgt atcctgtgcc gaaacctctt 1560
ttgatgcgca tcctcagcct tacacgagtg atagatgtta tttacaagaa cgaagactgg 1620
tacacgcatg tgaagaagcc catgaaagat aaaattgcat ccctacttat agatcccatg 1680
attgtttga                                                         1689

<210> 658
<211> 333
<212> DNA
<213> Scoparia dulcis

<220> 
<223> copalyl diphosphate

<400> 658
atgggatggg tcatacctac ctccacttcg ccggaagcag atgcaacgtg ggagcacggt 60
ttgtctgctg atgacgtgac cggcgtcaga ccagtcacag accggtcatt cttgtccacc 120
acgtgtcagt ttagcatgcc gcacgtctgt ccttcttcat acaatgactt ccttgcaatg 180
gttgcgatga agcctggaat gtatctggcc gggactggcg tgctaactcc aggagttagc 240
acgccggctc tggctaggga cgagtgcctg gaggctctca tcattccgac gggacggggc 300
gaggcgtgtg acaggctgcc tgctgccacc taa                              333

<210> 659
<211> 2030
<212> DNA
<213> Solanum habrochaites

<220> 
<223> sesquiterpene synthase 1

<220> 
<221> variation      
<222> 1721, 1723, 1773, 1832, 1850, 1859, 1880, 1882, 1894, 1901,
1904, 1908, 1913, 1926, 1929, 1948, 1949, 1978, 1989, 1997,
2004, 2008
<223> n = a or c or t or g

<400> 659
aaaaagagca aaccttagaa caaacaagca atggctgctt cttctgctaa taagtctcgt 60
cctttggcta attttcaccc aactgtttgg ggatatcatt tcctttctta tactcatgaa 120
attactaacc aagaaaaagt tgaagttgat gagtacaaag agacaattag aaaaatgttg 180
gtggaagctc ctgaaggtag tgaacaaaaa cttgtgttga tagacgcgat gcaacgattg 240
ggagtggcat atcatttcca taatgaaatt gaaacatcca ttcaaaacat ttttgatgcg 300
cccaaacaga acaacaacct tcacattgtt tctcttcgtt ttcgacttgt gaggcaacaa 360
ggacattaca tgtcttcaga tgtgttcaag caattcacca accaagatgg gaaattcaag 420
gaaacgctta ctaatgatgt ccaaggatta ttaagtttgt atgaagcatc atatctgaga 480
gtgcgtgatg aggagattct tgaagaagct cttgccttta ccactactca tctcaaatct 540
attgtctcaa ccatgagcaa taataataac tctcttaagg ttgaagttag tgaagcctta 600
actcagccta ttcgcatgac tttaccaagg atggaagcaa ggagatacat atccatttac 660
gaaaacaatg atgcacacaa ccatttgctt ttgaaatttg ctaaattgga tttcaacatg 720
ctgcagaagt tgcaccaaag agagcttagt gaccttacaa ggtggtggaa agatttggat 780
tttgcaaata aatatccata tgcaagagac aggttggttg agtgttactt ctggatatta 840
ggagtgtatt ttgagccaaa gtatagtcgt gcgagaaaaa tgatgacaaa agtactcaag 900
atgacctcca ttattgacga cacttttgat gcttatgcaa cctttgacga actagaacct 960
ttcaatgatg caatccagag atgggatgct aatgcaatcg attcaatacc accatatatg 1020
agacctgctt atcaagcttt tctagacatt tacagcgaaa tggaacaagt gttgtccaaa 1080
aaaggtaaac tggaccgcgt atactatgca aaaaatgaga tgaaaaagtt ggtgagagcc 1140
tattttaagg aaacccagtg gttgaatgat tgtgaccata ttccaaaata tgaggaacac 1200
atggagaatt cactcgtaag cggtggttat atgatgatac caacaacttg cttggtcggt 1260
atggaagaat ttatatccat agagactttt gaatggttaa tgaatgatcc tttgatagtt 1320
cgagcttcct cattgatagc cagagcaatg aacgatattg ttggacatga agttgaacaa 1380
gaaagaggac atgtagcttc acttattgaa tgttacatga aagattatgg agcttcaaag 1440
caagaggcat acgccaaatt caagaaagat gtcaccaatg catggaagga cataaacaaa 1500
gaattcttcc gtccaactga agtaccaatg tttgtccttg aacgagttct aaatttgaca 1560
cgtgcggctg aaccgttata taaagagaaa gatgcataca caaatgccaa aggaaaactt 1620
aaaaacatga ttaattcaat actaattgaa tctgtcaaaa tataaatata atgctgaaat 1680
tgccttccat cgttcaaata ttcagagcaa aaataagggc ntntaataaa ttggaagaac 1740
ctttaattat gctactcaca ccatattgag ttngtaaatt cctggggatg tttgaaataa 1800
acaataattg gttttaatta atttattaag cnaaagtgga aatttccacn cttggagtng 1860
gattaaatca tgtttaattn anttccactt gtangttggg nttntttntt ggnaaatatc 1920
atcacnttnt aatggacctg gaaccgaatg gatttggnnt gggattgggg gccataanaa 1980
aaattgaana aaaaatnttt ttgnttcnaa aaaaaaaaaa aaaaaaaaaa            2030

<210> 660
<211> 2000
<212> DNA
<213> Solanum habrochaites

<220> 
<223> sesquiterpene synthase 2

<400> 660
gcacgagaac aaacaagcaa tggctgcttc ttttgctaat aagtgtcgcc ccttggctaa 60
tttccaccca actgtttggg gatatcattt cctttattat aatcctgaaa ttactaacca 120
agaaaaaatt gaagttgatg agtacaaaga gacaattaga aaaatgttgg tggaagctcc 180
tgaaggtagt gaacaaaaac ttgtgttgat agacgcgatg caacgattgg gagtggcata 240
tcatttccat aatgaaattg aaacatccat tcaaaacatt tttgatgctc ccaaacagaa 300
caatgatgac aaccttcaca ttgtttctct tcgttttcga cttgtaaggc aacaaggaca 360
ttacatgtct tcagatgtgt tcaagcaatt caccaaccaa gatgggaaat tcaaggaaac 420
acttactaat gatgtccaag gattattgag tttgtatgaa gcatcacatc tgagagtgcg 480
taatgaggag attcttgaag aagctcttac atttaccacc actcatctcg agtctattgt 540
ctccaacttg agcaataaaa ataactctct taaggttgaa gttagtgaag ccttaagtca 600
gcctattcgc atgactttac caaggattgg agctagaaaa tacatatcca tttacgaaaa 660
caatgacgca cacaaccatt tgcttttgaa atttgctaaa ttggatttta acatgctgca 720
aaagtttcac caaagagagc ttagtgatct tacaaggtgg tggaaagatt tggattttgc 780
aaataaaatt ccatatgcaa gagacagatt ggttgagtgt tacttttgga tattaggagt 840
gtattttgag ccaaaatata gtcgtgcgag aaaaatgatg acaaaagtac tcaagatgac 900
ctccattatt gacgacactt ttgatgctta tgctaacttt gacgaacttg tgcctttcaa 960
tgatgcaatc cagagatggg atgctaatgc aatcgattca ataccgccat atatgagacc 1020
catttatcaa gctcttctag acatttacgg tgaaatggat caagtgttgt ccaaagaagg 1080
caaactggac cgtgtatact atgcaaaata tgagatgaaa aagttggtga gagcctattt 1140
taaggaatcc caatggttga acgatgataa tcatattcca aaatatgagg aacacatgga 1200
gaatgcaatc gtaactgttg gctatatgat gggagcaaca aattgcttgg ttggtatgga 1260
ggaatttata tctaaagaga cttttgaatg gttgatgagt gagcctgtga ttgttcgagc 1320
ttcctcattg atcggcagag caatggacga tattgttgga catgaagttg aacaagagag 1380
aggacatgta gcttcaatta ttgaatgtta catgaaagat tatggagctt caaagcaaga 1440
ggcttacgcc aaattcaaga aggatgtcac caatgcatgg aaggacataa acaaagaatt 1500
cttccgtcca actgaagtac caatgtttgt ccttgaacga gctttaaatt tcacacgtgt 1560
gatagacacg ttgtatcaag aggaagatga atatacaaac gccaaaggca aacttaaaaa 1620
catgattcac tcgatactga ttgaatctgt caaaatataa atataatgat gaaattgcac 1680
cttcatcatt caaatattca gagcaaaata aggcacatac aataaattga agacctttaa 1740
tatgctattc ataatatatg agctgttaat gaaataaaca atagttgttt ttaatttact 1800
tagcaaaagt gtgattggtt tgtctttttc ctgttttcaa aaaatataca acactcagag 1860
ttgtattaaa tcctgtttta tttcatttcc agcttgttgg atgattgtta attatcatca 1920
ctttataatg tattgtattt atattgtatt gttatcgtaa taaaatttga ataaattata 1980
tctttaaaaa agaaaaaaaa                                             2000

<210> 661
<211> 1647
<212> DNA
<213> Solanum lycopersicum

<220> 
<223> caryophyllene/alpha-humulene synthase

<400> 661
atggcttctt cttctgctaa taagtgtcgt cccttggcta attttcaccc aactgtttgg 60
ggatatcatt tcctttctta tactcatgaa attactaacc aagaaaaagt tgaagttgat 120
gagtacaaag aaacaattag aaaaatgctg gtggaagctc ctgaaggtag tgaacaaaaa 180
cttgtgttga tagacgcgat gcaacgattg ggagtggcat atcattttga taatgaaatt 240
gaaacatcca ttcaaaacat ttttgatgca tcgtccaaac agaatgataa tgacaacaac 300
ctttacgttg tgtctcttcg ttttcgactt gtgaggcaac aaggccatta catgtcttca 360
gatgtgttca agcaattcat caaccaagat gggaaattca aggaaacgct tactaatgat 420
gtccaaggat tattgagttt gtatgaagcg tcacatctga gagtgcgcga tgaggagatt 480
cttgaagaag ctcttacctt taccaccact catctcgagt ctactgtctc caacttgagc 540
aataataact ctcttaaggc tgaagtaact gaagccttta gtcagcctat tcgcatgact 600
ttaccaaggg tgggagcaag gaaatacata tccatttacg aaaacaatga tgcacacaac 660
catttgcttt tgaaatttgc taaattggat ttcaacatgc tgcaaaagtt gcaccaaaga 720
gagcttagtg accttacaag gtggtggaaa gatttggatt ttgcaaataa atatccatat 780
gcaagagaca ggttggttga gtgttacttc tggatattag gagtgtattt tgagccaaag 840
tatagtcgtg cgagaaaaat gatgacaaaa gtaatccaaa tggcctcctt ctttgatgac 900
acttttgatg cttatgcaac ctttgacgaa ctagaacctt tcaacaatgc aatccagaga 960
tgggatatta atgcaatcga ttcagtaccg ccatatctga gacatgctta tcaagctctt 1020
ctagacatat acagtgaaat ggaacaagcg ttggccaaag aatttaaatc agatcgtgta 1080
tactatgcaa aatatgagat gaaaaagttg gtgagagcct attttaagga agcccaatgg 1140
ttaaacaatg ataatcatat tccaaaatat gaggaacaca tggagaatgc gatggtaagt 1200
gctggctata tgatgggagc aacaacttgc ttggttggtg tggaggaatt tatatccaaa 1260
gagacttttg aatggatgat aaatgaacct ttgatagttc gagcttcctc attgattgcc 1320
agagcaatgg acgatattgt tggacatgaa gttgaacaac aaagagaaca tggagcttca 1380
cttattgaat gctacatgaa agattatgga gtttcaaagc aagaggctta cgttaaattc 1440
cagaaagaag tcaccaatgg atggatggac ataaacagag aattcttctg tccagacgta 1500
gaagtaccaa agtttgtcct tgaacgagtg ctaaatttca cacgcgtgat aaacacgtta 1560
tataaagaga aggatgagta cacaaactcc aaaggaaaat ttaaaaatat gataatttcg 1620
ttactggttg agtctgtcga aatatga                                     1647

<210> 662
<211> 2403
<212> DNA
<213> Solanum lycopersicum

<220> 
<223> copalyl diphosphate synthase

<400> 662
atgtcgatct cagcttcttt tttaagattt agcctcactg ctcactatca accttctcct 60
tcttcttctc caccaaatca acctttcaaa ttccttaaaa gcaacagaga acatgttgaa 120
ttcaatcgaa ttttgcaatg tcatgctgtt tctagacgtc gtacaaaaga ttacaaagag 180
gtgcaaagtg gttcgttgcc ggttatcaag tgggacgaca tagcagagga agtggacgag 240
gaaacacaca cacttgaggt gtacgatcca tcctccaacg aggaccatat cgatgctatt 300
cgatcgatgc taggatcaat gggagacgga gaaataagcg tctcggccta tgacacagca 360
tgggttgcca tggtgaaaga tgtgaagggg actgaaactc ctcagttccc ttcaagcctt 420
gagtggattg cgaacaatca gttggctgat ggttcatggg gtgacaactc cattttcttg 480
gtttatgatc gtgtcatcaa cacattggct tgtgttattg ccttgaagtc atggaacttg 540
catcctgaca agattctact tggaatgtcg tttatgagag agaatttgag caggattggt 600
gatgagaatg cagagcacat gcctataggc ttcgaagtgg catttccttc actcattgag 660
attgctaaaa agttaggctt agattttcct tatgattctc ccgtcttgca agacatctat 720
gccagtagac aactaaagct tacaaggata ccaaaggaca tcatgcacaa agtccccaca 780
actttactcc acagtttgga aggaatgaca gatttggact ggcaaaagtt gcttcaattt 840
cagtgcactg atggctcttt tctcttctct ccatcttcca ccgcatatgc acttatgcaa 900
actcaagatc ataattgtct caattatctc aaaaatgctg tccacaaatt caacggcgga 960
gttccaaatg tgtatccagt ggacctattt gaacatattt ggaccgttga tcggttgcaa 1020
aggcttggaa tttctcggta ttttgagcta aaaataaaaa agtgcattga ttactttagc 1080
aaatattgga caaataaagg aatctgctgg gctagaaatt ccccagttca agacattgat 1140
gacacggcta tggcttttag acttttgcgc ttgcatggct acgctgtttc tgctgacgta 1200
ttcaaacatt ttgagagcaa aggcgaattt ttctgcttcg tggggcaatc aaatcaagca 1260
gtgacaggaa tgtataatct ttatagggca tctcatgtaa tgttctcagg agagaaaata 1320
cttgaaaatg caaaaatatc cacttctaat tatctaagag aaaaacgagc tcaaaatcaa 1380
ctgctagaca agtggatcat tactaaagat ttacctggag aggtgggata tgcattagat 1440
gtgccatggt atgctagcct accccgccta gaaacaaggt tctttttaga acattatggt 1500
ggtgaagatg acgtgtggat tggcaaaaca ttgtacagga tgccattggt taacaatagc 1560
ctatacctag agctagcgaa atcggactat aacaattgcc aagctttgca ccagttcgag 1620
tggagaagaa ttcgcaagtg gtactacgaa tgcgggctaa gagagtttgg attaagtgaa 1680
aaaaggttgt tggttacgta ctatttaggc agtgctagta tatttgaggc acaaaggtcg 1740
accgagcgaa tggcttgggt caaaaccgca gctcttatgg actgtgtgag gtcttgtttt 1800
ggctccccac aagtatctgc agctgcattt ctttgcgaat tcgcacacta ctctagcacc 1860
gctctgaatt cgaggtacaa cacagaagat aggctcgttg gggtcattct tggaacccta 1920
aatcatctct cactgagtgc cttattaaca catggcagag acatccatca ctacttgcgt 1980
catgcttggg aaaattggct actgacggta ggagaaggag aaggagaagg agaaggaggt 2040
gctgaactca taattcgcac cttaaatttg tgcagtgttc attggatatc ggaggagata 2100
ttgttgtccc atccaactta ccaaaagcta ttggaaatta ccaatagagt ttctcaccga 2160
ctccgtctct acaagggaca cagtgaaaag caggtaggaa tgttgacttt tagtgaagaa 2220
atagaaggtg acatgcaaca gctagcagag ctcgtgctat ctcattcaga tgcttccgaa 2280
ttggatgcca atatcaaaga cacttttctc actgttgcca aaagttttta ctactcagct 2340
tattgtgatg atcgaacaat taactttcac atagccaaag tgctatttga aagagtagtt 2400
taa                                                               2403

<210> 663
<211> 2024
<212> DNA
<213> Solanum lycopersicum

<220> 
<223> germacrene C synthase

<400> 663
aaaaaaagcc aaaccttaga acaaacaagc aatggctgct tcttctgctg ataagtgtcg 60
ccccttggct aattttcacc catctgtttg gggatatcat ttcctttctt atactcatga 120
aattactaat caagaaaaag ttgaagttga tgagtacaaa gagacaatta gaaaaatgct 180
ggtggaaact tgcgacaata gcactcaaaa gcttgtgttg atagacgcga tgcaacgatt 240
gggagtggct tatcatttcg ataatgaaat tgaaacatcc attcaaaaca tttttgatgc 300
atcgtccaaa cagaatgata atgacaacaa cctttacgtt gtgtctcttc gttttcgact 360
tgtgaggcaa caaggccatt acatgtcttc agatgtgttc aagcaattca ccaaccaaga 420
tgggaaattc aaggaaacac ttactaatga tgtccaagga ttattgagtt tgtatgaagc 480
atcacatctg agagtgcgta atgaggagat tcttgaagaa gctcttacat ttaccaccac 540
tcatctcgag tctattgtct ccaacttgag caataataat aactctctta aggttgaagt 600
tggtgaagcc ttaactcagc ctattcgcat gactttacca aggatgggag ctagaaaata 660
catatccatt tacgaaaaca atgatgcaca ccaccatttg cttttgaaat ttgctaaatt 720
ggattttaac atgctgcaaa agtttcacca aagagagctt agtgatctta caaggtggtg 780
gaaagatttg gattttgcaa ataaatatcc atatgcaaga gacaggttgg ttgagtgtta 840
cttctggata ttaggagtgt attttgagcc aaaatatagt cgtgcgagaa aaatgatgac 900
aaaagtactc aacctgacct ccattattga cgacactttt gatgcttatg caacctttga 960
cgaacttgtg actttcaatg atgcaatcca gagatgggat gctaatgcaa ttgattcaat 1020
acaaccatat atgagacctg cttatcaagc tcttctagac atttacagtg aaatggaaca 1080
agtgttgtcc aaagaaggta aactggaccg tgtatactat gcaaaaaatg agatgaaaaa 1140
gttggtgaga gcctatttta aggaaaccca atggttgaat gattgtgacc atattccaaa 1200
atatgaggaa caagtggaga atgcaatcgt aagtgctggc tatatgatga tatcaacaac 1260
ttgcttggtc ggtatagaag aatttatatc ccacgagact tttgaatggt tgatgaatga 1320
gtctgtgatt gttcgagctt ccgcattgat tgccagagca atgaacgata ttgttggaca 1380
tgaagatgaa caagaaagag gacatgtagc ttcacttatt gaatgttaca tgaaagatta 1440
tggagcttca aagcaagaga cttacattaa gttcctgaaa gaggtcacca atgcatggaa 1500
ggacataaac aaacaattct cccgtccaac tgaagtacca atgtttgtcc ttgaacgagt 1560
tctaaatttg acacgtgtgg ctgacacgtt atataaggag aaagatacat attcaaccgc 1620
caaaggaaaa cttaaaaaca tgattaatcc aatactaatt gaatctgtca aaatataaat 1680
ataatgctga aattgcacct tcatcatcca actattcaca gcaaaataag gcatataata 1740
aattgaagac tcacaacata tgagttgtta attcctggga tgtttgaaat aaacaataat 1800
tgtttttatt taatttgcta agccaaagtg aaatatacaa cacttgagtt gtattaaatc 1860
atgttttatc tcatttccag cttgtgagtt tggattatta tattgttaat tatcatcact 1920
ttataatgta ctgtaatcgt attgtatttg tattgtagtg ttgtcataat aaaatttgaa 1980
taaaatatat ttttgtttca attccaaaaa aaaaaaaaaa aaaa                  2024

<210> 664
<211> 2539
<212> DNA
<213> Solanum lycopersicum

<220> 
<223> vetispiradiene synthase

<400> 664
ctcacaattc attcattata aatactcata tctcttctct tacaattcca tcatcatttg 60
ttcaattctc tactacagtc tacaaacata taacataacg aaggaaattt tttcagaaac 120
aaagagtata gtataaatgg cctcagctgc tgcattggtg agcaactaca gagaggagga 180
gattgttcgc cctgttgctg acttctctcc aagtctttgg ggtgatcgtt tccattcatt 240
ctcccttgac aataaggtat tgatatattt tctacgagtc tttcattttt ctttatcttg 300
ttggatgact ttgaatgtaa catacatttt cttttttaaa aaaatatttg cagattgctg 360
gaaaatatgc tcaagaaatt gaaactttga aggaacaatc aagagtaata ttatctgcat 420
cttctggaac aacattggct cagaaattgg atctgataga cattgttgag cgacttggct 480
tagcttatca ttttgagaaa caaatagacg atgtgttgga tcaaatttac aaagcagatc 540
ctaactctga ggctcaggaa tacaatgatt tacaaacttc atccatccaa tttcgactat 600
tgagacaaca tggttacaat atctcgccga gtaggtctat tatacacatg tttttcattg 660
attgttatat ttgtgtttct tgcttacacc aaggaatttt tgttttcttt ttactttttc 720
ttactaaaaa ctaatctttt atttttgttt atgatccaga actttttagc agattccaag 780
atgcaaaagg caaatttaac gaatctctta gcaacgacat caagggtctt ttgaacttat 840
atgaagcctc acatgtaagg actcatggag aagatatttt ggaagaggca cttgctttct 900
ctactgctca tcttgaatct gcagctccac atttgaagtc acctctgagt aagcaagtga 960
ctcatgccct tgagcaatct ctccataaga gcattccaag agttgagaca cgatacttca 1020
tctctatcta cgaagaggag gaacagaaga atgatttgtt gcttcgattt gcaaaactgg 1080
acttcaactt acttcagatg ttgcacaaac aagaactcag tgaagtatca aggttttgct 1140
agtaatttac atgaaaaata ttactactat taattgttta tagtgactct cagaatctta 1200
tatatatatt gttacttact ttgtaggtgg tggaaagatt tggattttgt gacaaccctt 1260
ccatatgcta gggatagagc agtcgaatgt tacttctgga cgatgggagt gtatgctgaa 1320
ccacaatact ctcaggctcg tgtcatgctt gctaagacta tagcaatgat ttcgatagta 1380
gatgacacat tcgatgctta tggcattgta aaagaactgg aggtctacac cgatgccata 1440
cagaggtatg gactacttct tatcatttaa ttggaagatc ccataaaggt gggaaaaaac 1500
catatcaaac aacatgttta tgtccaattt taattttttg cctacaattt attatccgag 1560
acaagcctag gagttaaaca ctagagattt ctgcttcttc tatgatatat gttcttttaa 1620
attgattact tatcaatttt attttatttt aatttatcag gtgggatatt agccatattg 1680
atcggctccc tgattacatg aaaatcagtt acaaagcact tttagatctc tacgatgatt 1740
atgaaacaga actgtcaaag gatggcagat ccgatgttgt acactacgct aaagaaagag 1800
tatgaatata atcagttata tcagtcacct aatttttttt tgaataaata gtgatgtttg 1860
aatgtcttta cctgttgttg acagatgaaa gaaattgtga gaaactattt tgtggaagca 1920
aaatggttca ttgaaggata catgccacca gtttctgagt atctttgcaa tgcattagct 1980
accagcactt attacttgct taccactaca tcctacttgg gcgtgaaatc tgctaacaag 2040
gaagattttg aatggttggc aaagaaccct aaaattcttg aagccaatgt gacactatgc 2100
cgagtcattg atgacatagc cacctatgat gttgagaagg gtagaggtca gattgcaact 2160
ggaattgaat gttacatgag agattatggc gtatccacag aagaggcaat ggaaaaattt 2220
gaagagatgg ctgagatagc atggaaggat gtaaatgaag gaatccttcg accaactcct 2280
gtctctacgg agattctcac tcgcattctc aatcttgctc gcattattga tgtcacttat 2340
aaacacaatc aagatggata caggcatcct gaaaaagtac taaaacctca tattattgcg 2400
ttgttggtgg actctattga aatttaaatc atctattgtt ttgtacattt gggagcactt 2460
gcttcctatc ccctaaaatt atagtaagta tttgattgat gccttgttgg tatctacgct 2520
gctagctaag atgggagtt                                              2539

<210> 665
<211> 1848
<212> DNA
<213> Solanum tuberosum

<220> 
<223> putative vetispiradiene synthase 4

<400> 665
atttctctaa gcacaaaacc aacaaaatta acacttcttt ttcacaagct aactgtagaa 60
gaaattaaat ggccctagct gctgcagtga tgagtaacta cggagaggag gagattgttc 120
gccctgttgc tgacttctct ccaagtcttt ggggtgatcg tttccattat ttctccctcg 180
ataatcaggt tgaaaaagag tatgctcaag agattgaaac attgaaagag caaacaagga 240
gtatgttgtt agctgcgagt ggaatgacat tggctgagaa gttgaatctg atagacattg 300
ttgagcgcct tggcttagct taccattttg agaaacaaat agaagacatg ttggatcaaa 360
tttacaaagc acatcctaac tttgagagtc atgaatacag tgacttaact actttatccg 420
ttcagtttcg actactgaga caacatggtt acaatatctc tccaaaaatt tttagcagat 480
accaagatgc aaagggaaaa tttaacgaac cccttagcaa cgacatcaaa ggtctattga 540
acttatatga agcttcacat gtaaggactc atggagaaga catcttagaa gaggcacttg 600
ctttctccac tgctcatctt gaatctgcag ctccacattt gaagtcacct ctgagtaagc 660
aagtcacaca tgcccttgag caatctctcc ataagagcat tccaagagtt gagacacgat 720
acttcatctc tatctacgaa gaggaggaac ataagaatga tgtgttgctt cgatttgcaa 780
aactggactt caacttactt cagatgttgc acaaacaaga actcagtgaa gtatcaaggt 840
ggtggaaaga tttggatttt gtgacaacac ttccatatgc tagggataga gcagtcgaat 900
gttacttttg gaccatggga gtgtatgctg aacctcaata ctctcaggct cgtgttatgc 960
ttgctaagac tatagcaatg atttctatag tagatgacac attcgatgct tatggaatcg 1020
taaaagaact cgaggtttac accgatgcca tacagaggtg ggatatcagc caaattgatc 1080
ggctcccaga ttacatgaaa atcagttata aagcacttct agatctctac aacgattatg 1140
aaacagagtt gtcaatggat ggtagatccg atgttgttca ctacgccaaa gaaagaatga 1200
aagaaatcgt gagaaactat tttgtggaag caaaatggtt cattgaagga tacatgccac 1260
ctgtttctga gtatcttagc aatgcattag ctactagcac ttattacttg cttacgacaa 1320
catcctactt gggcgtgaaa tctgctaaca aggaagattt tgaatggttg gctaagaacc 1380
ctaaaatcct tgaagccaat gtgactttat gtcgagtcat tgatgatata gcaacctatg 1440
aagttgagaa gggtagaggt cagattgcaa ctggaattga gtgttatatg agggattatg 1500
gcgtatcaac agaagtagca atggaaaaat tccaagagat ggctgagata gcatggaagg 1560
atgtaaatga aggaattctt cgaccaacac ctatctctac agaaatcctt actcgtattc 1620
tcaatctggc tcgtattata gatgtcactt acaagcacaa tcaagatgga tacactcatc 1680
cagagaaggt tctaaaacct cacattatcg ctttgttggt agattctatt gaaatttaaa 1740
ttatcaattc accaaggaat acttggtact tctcagtccc ttaaataagt aattggtgat 1800
atcgtgcaat gaagtaactt tcttaaaaaa aaaaaaaaaa aaaaaaaa              1848

<210> 666
<211> 1944
<212> DNA
<213> Solanum tuberosum

<220> 
<223> vetispiradiene synthase

<400> 666
gaaagaaaga aaattctctc tgttttttcc acaagcaaag agtacacaca ctagaaatga 60
ccccagctgc tgtagtaatg agtaactacg gagaggagga gattgttcgc cccatagctg 120
acttctctcc aagtctttgg ggtgatcgtt ttcattcatt ctccctcgac aatcagattg 180
ctggaaaata tgctcaagag atcgaaactt tgaaggaaca atcaagaatt atattatctg 240
catcttctcg aagaacattg gctgagaaat tggatctgat agacattgtt gagcgccttg 300
gcattgctta tcattttgaa aaacaaatag atgatatgtt ggatcaattt tacaaagcag 360
atcctaactt tgaggctcac gagtacaatg atttacaaac tttatccgtt caatttcgac 420
tattgagaca acatggttac aatatctccc caaaactttt tattagattc caagatgcaa 480
aaggcaaatt taaagaatct ctttgtaacg acatcaaggg tcttttgaac ttatacgaag 540
cctcgcatgt aaggactcat ggagaagata ttttggaaga ggcacttgct ttctctactg 600
ctcatcttga atctgcagct ccacatttga agtcacctct gagtaagcaa gtgacacatg 660
cccttgagca atctctccat aagagcattc caagagttga gacacgctac ttcatctcta 720
tctacgaaga ggaggaacag aagaatgatg tgttgcttca atttgcaaaa ctggacttca 780
acttacttca gatgttgcac aaacaagaac ttagtgaagt atcaaggtgg tggaaagatt 840
tggattttgt gacaacactt ccatatgcta gggatagagc agtggaatgc tacttttgga 900
cgatgggggt gtatgctgaa cctcaatact ctcaggctcg tgtcatgctt gctaagacta 960
tagcaatgat ttctatagta gatgacacat tcgatgctta tggcattgtc aaagaacttg 1020
agatctacac cgatgccata cagaggtggg atattagcca aattgatcgg ctccctgatt 1080
acatgaaaat cagttacaaa gcacttttag atctctacaa tgattatgaa atggagttgt 1140
ccaaggatgg tagatctgat gttgttcact acgcgaaaga aagaatgaaa gaaatcgtga 1200
gaaactattt tgtggaagca aaatggttca ttgaaggata tatgccgcca gtctctgagt 1260
atcttagcaa tgcattagct accagcactt attacttgct tacgactaca tcttatttgg 1320
gcatgaagtc tgctaacaag caagattttg aatggttggc caagaaccct aaaattcttg 1380
aggctaatgt gacgttatgc cgagtcatag atgacatagc cacctatgag gttgagaagg 1440
gtagaggtca gattgccact ggaattgaat gttacatgag agattatggt gtatccacag 1500
aaaaggccat ggaaaaattc caagaaatgg ctgagacagc atggaaggat gtaaatgaag 1560
gaatccttcg accaactccc gtctctacag agattctcac tcgcattctc aatcttgctc 1620
gcattatcga tgttacttat aagcacaatc aagatggata cactcatccg gaaaaagtac 1680
taaaacctca tattattgcg ttgttggtgg actctattga aatttaaatc atcgattgtt 1740
ttgtacatct gggagcactt gcttcccatc ccctaaaatt ataagtattt gattgatgcc 1800
ttgttggtat ctatgctgct aggcgctagc taagatagga gttgctggag atacatgtta 1860
tagtgcagtg cagttaattc cttaattttt ttttgtatca ttattgacat tttaaatata 1920
tatatatata tcactgcttt ttat                                        1944

<210> 667
<211> 1976
<212> DNA
<213> Solidago canadensis

<220> 
<223> germacrene A synthase

<400> 667
aaaattttaa tcaacataag aatctaagtc catataaaac atggctgcta aacaagtaga 60
ggttattcgc ccagttgcaa actatcatcc aagcctttgg ggagatcagt ttctacacta 120
tgatgagcaa gaggatgagc acgttgaggt agatcaacaa atcgaaattt tgaaggaaga 180
aacgcgaaaa gaaatacttg caagtttgga tgatccaaca aaacatacaa atttgctgaa 240
gctgattgat gttatccaac gtctcggtat agcctattat tttgaacatg agattacgca 300
agcattggac catatttata gtgtatacgg tgatgaatgg aatggtggtc gtacttccct 360
ttggtttcgg ctcctccgac aacaaggctt ttacgtttca tgtgatattt tcaatatcta 420
caagcttgat aatggatctt tcaaggattc cttaaccaag gatattgaat gcatgcttga 480
gttatatgag gcagcctata tgagggtgca aggcgaaatc attctagatg aggctcttga 540
gtttacaaaa actcatcttg aacacattgc aaaggatcca cttcgttgca acaacacgct 600
ctctagacac atacatgaag cactagagcg gcctgtacag aaaaggttgc caagactaga 660
tgcaatacga tacatacctt tctatgaaca acaagattct cacaacaagt ccttactaag 720
acttgcaaag ttggggttca accggcttca atccttgcat aagaaggagc ttagccaact 780
ttccaaatgg tggaaagaat ttgatgctcc aaagaatcta ccttacgtaa gagatagatt 840
ggttgaactc tacttttgga tactaggtgt ctacttcgaa cctcaatatt ctcgttcgag 900
aatattcttg acaaaaacaa ttaaaatggc agcaattcta gacgacacgt atgatatcta 960
tggtacttac gaagaacttg agatattcac caaagccgtt caaaggtggt caattacctg 1020
catggatacg cttccagatt acatgaaagt gatttataag agcctcttgg atgtttatga 1080
agaaatggag gaaatcatag aaaaggatgg aaaagcatat caagttcact atgcaaaaga 1140
gtcgatgata gatttggtta caagttatat gaccgaagca aaatggttac atgagggtca 1200
tgtgccaaca tttgacgagc ataactcagt tacaaacata actggtggct ataaaatgct 1260
tacagcatca agctttgttg gcatgcatgg tgatatagtt acacaagagt ctttcaaatg 1320
ggttctcaac aatcctccac ttataaaagc ttcatctgac attagtagga ttatgaatga 1380
tatcgtcggt cacaaggagg agcaacaaag aaagcatatt gcatctagtg tggaaatgta 1440
catgaaagaa tataatctcg cggaggagga cgtctatgat tttctcaaag aaagagttga 1500
agatgcatgg aaagatataa accgagaaac attaacatgt aaagacattc atatggctct 1560
taagatgcct ccgatcaacc tggcacgcgt aatggatatg ctatacaaaa acggtgataa 1620
tttaaaaaat gttggacaag aaatccaaga ttatatgaaa tcttgtttca ttaatcctat 1680
gagtgtttga tttttggtcc ttcatgacca attatcacgt ctcatagatc tgaaagatgt 1740
tggttcgcac ttttgaaaga tgcaaggtta tggtaccaca ctaaataaga cctcaagtcc 1800
actggagcta taaaactata tatagctgat acgtattgta tttgtggatt ttaatttatg 1860
tattgtattt catgtatttg tggattttaa tctatgtatt ttatttcatg tattttgtgg 1920
attttaattt atgttattgt atttcatgtt tttcgatgga aaaaaaaaaa aaaaaa     1976

<210> 668
<211> 1816
<212> DNA
<213> Solidago canadensis

<220> 
<223> germacrene D synthase

<400> 668
ataaaacatg gctgctaaac aaggagaggt tgttcgccca gatgcagact actcgtatca 60
tccaagcctt tggggagatc agtttctaca ctatgatgag caagaggatg atcaagttga 120
ggtagatcaa caaatcgaaa ttttgaagga agaaacgaga agagaaatac tctcaagttt 180
ggatgatcca gcaaaacata caaatttgct gaagctgatt gatgttatcc aacgtctcgg 240
tatagcctac tattttgaac atgagattac gcaagcattg gaccatattt ataatgtata 300
cggtgatgaa tggaatggtg gtagtacttc cctttggttt cggctcctcc gacaacaagg 360
cttttatgtt tcatgtgata ttttcaatat ctacaagctt gataatggat ctttcaagga 420
ttccttaacc aaggatattg aatgcatgct tgagttatat gaggcagcct atatgagggt 480
gcaaggcgaa atcattctag atgaggctct tgagtttaca aaaactcatc ttgaacaaat 540
tgcaaaggat ccccttcgtt gcaacaacac gctctctaga cacatatatg aagcgctgaa 600
gcggcctata cggaaaaggc taccaagagt ggatgcatta caatacatgc ctttctatga 660
acaacaagat tcacacaaca agtccttact aagacttgca aagttggggt tcaaccggct 720
tcaatccttg cataagaagg agcttagcca actttccaaa tggtggaaag aatttgatgc 780
tccaaagaat ctacgttacg taagagatag attggttgaa ctctactttt gggtactagg 840
tgtctacttc gaacctcaat attctcgttc aagaatattc ttgacgaagg taattaaaat 900
ggccacgatt ctagacgaca cgtatgatat ccatggcact tacgaagaac ttgagatatt 960
taccaaagcc gttcaaaggt ggtcaattac ctgcatggat acgcttccag attacatgaa 1020
aatgatttat aagagcctct tggatgttta tgaagaaatg gaggaaatca tagagaagga 1080
tggaaaagca tatcaagttc actatgcaaa agactcgatg atagatttgg ttacaagtta 1140
tatgaccgaa gcgaaatggt tacatgaggg tcatgtgcca acatttgagg agtataactc 1200
aattacaaac ttaactggtg gctataaaat gcttacaaca tcaagttttg ttgacatgcc 1260
tggtgatata gttacacaag agtctttcag atgggctctt aacaatcctc cacttataaa 1320
agcttcagct gacgttagta ggattatgga tgatatcgtc gggcacaagg aggagcaaca 1380
aagaaagcat cttccatcta gggtggaaat gtacatgaaa aaatatcatc ttgcggagga 1440
ggacgtctat gatttgctca aacaaagagt tgaagatgca tggaaagatc taaaccgaga 1500
aacattaaca tgtaaagaca ttcatatggc tcttaagatg cgtccgatca acctggcacg 1560
cgtaatagat atgctataca aaaacgatga taacttaaaa aatgttggac aagaaatcca 1620
agattatatc aaatcttgtt tcattaatgc tattagtgtt tgatttttgg tccttcatga 1680
ccaattatca cgtctcatag atctgaaaga tgttggttcg gtacttttga aagatgcaaa 1740
ggttatggta ccatactaaa taagacctca agtccatcgg agctataaaa aaaaaaaaaa 1800
aaaaaaaaaa aaaaaa                                                 1816

<210> 669
<211> 2590
<212> DNA
<213> Stevia rebaudiana

<220> 
<223> (-)-copalyl diphosphate synthase

<400> 669
gcaaaacaaa tccctctgat cctttcacca tgaagaccgg cttcatctct cccgccaccg 60
tcttccacca ccgtatttct ccggcaacca ccttccgcca ccacctttct ccggcgacca 120
ccaactccac tggaattgta gctcttagag acatcaactt ccggtgtaaa gcggtatcca 180
aagagtactc tgatttacta caaaaagatg aggcttcatt taccaagtgg gacgatgaca 240
aagtgaagga ccatttggac acaaataaga atttgtatcc aaacgatgag atcaaggagt 300
ttgttgagag cgtgaaagca atgtttggtt ctatgaatga cggagaaata aatgtgtcag 360
cgtatgatac ggcttgggtt gcactcgtgc aagatgttga tggaagtggt tcccctcaat 420
ttccatcaag tttggagtgg atcgcgaaca atcaactctc agatgggtct tggggcgatc 480
atttgttatt ttcggctcat gataggatca ttaacacgtt ggcatgtgtt atagcgctta 540
cttcttggaa cgtccatcca agtaaatgtg aaaaaggact gaattttctt agagaaaaca 600
tatgtaaact cgaagacgag aacgcggaac atatgccaat tggttttgaa gtcacgttcc 660
cgtcgctaat agatatcgca aagaagctaa atattgaagt tcctgaggat actcctgcct 720
taaaagaaat ttatgcaaga agagacataa aactcacaaa gataccaatg gaagtattgc 780
acaaagtgcc cacaacttta cttcatagtt tggaaggaat gccagatttg gaatgggaaa 840
aacttctgaa attgcaatgc aaagatggat catttctgtt ttctccatca tctactgctt 900
ttgcactcat gcaaacaaaa gatgaaaagt gtcttcagta tttgacaaat attgttacca 960
aattcaatgg tggagttccg aatgtgtacc cggtggatct attcgaacat atttgggtag 1020
ttgatcgact tcaacgactt gggattgctc gttatttcaa atcagagatc aaagattgcg 1080
ttgaatatat taacaagtat tggacaaaga atgggatttg ttgggcaaga aacacgcacg 1140
tacaagatat tgatgatacc gcaatgggat ttagggtttt aagagcacat ggttatgatg 1200
ttactccaga tgtatttcga caatttgaga aggatggtaa attcgtatgt ttcgctggac 1260
agtcaacaca agccgtcacc ggaatgttca atgtgtatag agcgtcacaa atgctctttc 1320
ccggagaaag aattcttgaa gatgcaaaga aattttcata taattatttg aaagaaaaac 1380
aatcgacaaa tgagcttctt gataaatgga tcatcgccaa agacttacct ggagaggttg 1440
gatatgcgct agacatacca tggtatgcaa gcttaccgcg actcgagaca agatattact 1500
tagagcaata cgggggcgag gatgatgttt ggattggaaa aactctatac aggatgggat 1560
atgtgagcaa taatacgtac cttgaaatgg ccaaattgga ctacaataac tatgtggccg 1620
tgcttcaact cgaatggtac actatccagc aatggtatgt tgatatcggt atcgaaaagt 1680
ttgaaagtga caatatcaaa agcgtattag tgtcgtatta cttggctgca gccagcatat 1740
tcgagccgga aaggtccaag gaacgaatcg cgtgggctaa aaccaccata ttagttgaca 1800
agatcacctc aatttttgat tcatcacaat cctcaaaaga ggacataaca gcctttatag 1860
acaaatttag gaacaaatcg tcttctaaga agcattcaat aaatggagaa ccatggcacg 1920
aggtgatggt tgcactgaaa aagaccctac acggcttcgc tttggatgca ctcatgactc 1980
atagtcaaga catccacccg caactccatc aagcttggga gatgtggttg acgaaattgc 2040
aagatggagt agatgtgaca gcggaattaa tggtacaaat gataaatatg acagctggtc 2100
gttgggtatc caaagaactt ttaactcatc ctcaatacca acgcctctca accgtcacaa 2160
atagtgtgtg tcacgatata actaagctcc ataacttcaa ggagaattcc acgacggtag 2220
actcgaaagt tcaagaacta gtgcaacttg tgtttagcga cacgcccgat gatcttgatc 2280
aggatatgaa acagacgttt ctaaccgtca tgaaaacctt ctactacaag gcgtggtgtg 2340
atccgaacac gataaatgac catatctcca aggtgttcga gattgtaata tgaaaacagc 2400
taattataat atggttgagt aagtgttgaa tggtaattta gatatcccaa tgtccatctt 2460
gagttagatt attcaatgtt ttaataaccg ggtcgggttg tgtgaccgtc ggaccagttt 2520
caaaagcata tattagaatt ttgatgatag gtgtgtaatt gttaaatatt aataaattgt 2580
gtctttaact                                                        2590

<210> 670
<211> 2792
<212> DNA
<213> Stevia rebaudiana

<220> 
<223> (-)-ent-kaurene synthase

<400> 670
cccactcatc ctttatcaac caataccatc gttctgccac cggaagactg atacgcgacg 60
gacctgacga cgcctttaat ctctgttgga ccacctaaca aaattccgac catcagatct 120
actccggtgg acagtttcat ttgcaattta gtaaatcagc aaactaaaca tcaatgaatc 180
tttcactatg catcgcgtcc cctttgttaa ccaaatcaaa tcgacccgcg gctctgtcag 240
ctattcatac agcatcaact tcacatggtg gacaaactaa tcccactaat ctgatcattg 300
atacaaccaa agaacggatc caaaaacagt ttaaaaatgt agaaatttct gtttcttcat 360
atgacacagc atgggtagcc atggtccctt ctccaaactc acccaaatcg ccttgtttcc 420
ctgagtgtct caattggtta attaataatc agcttaatga tggttcatgg ggtcttgtta 480
atcacactca taatcataat cacccgttgc ttaaagattc tctatcttca acattagcat 540
gtattgttgc attaaaaaga tggaatgttg gggaagatca aataaataaa ggtctaagtt 600
ttattgagtc aaatcttgct tcagctactg aaaaaagtca accatctccc attggttttg 660
acatcatatt tcctggtttg cttgagtatg cgaaaaactt ggacataaac ctcctttcaa 720
aacaaacaga ttttagtttg atgctacata agagggaatt ggagcaaaaa agatgccatt 780
caaatgagat ggatggatac ttggcgtata tctctgaagg actcggtaat ttatatgatt 840
ggaatatggt gaagaaatat cagatgaaaa atggttctgt tttcaactca ccatcagcaa 900
cagctgctgc tttcattaat catcaaaatc ctggttgtct taattattta aattcacttt 960
tggacaagtt tggtaatgca gtcccaacag tttatcctca tgatttattt atccgacttt 1020
ctatggttga cacaattgaa agattaggaa tttcacacca tttcagagtg gaaattaaaa 1080
atgttttaga tgaaacatac agatgttggg tggaacgaga tgagcaaata ttcatggatg 1140
ttgtaacatg tgctttagcc tttcggttat taaggatcaa tgggtatgaa gtttccccag 1200
atccattggc tgaaattact aatgaattag ctttgaaaga cgaatatgca gctcttgaaa 1260
catatcatgc gtcacatata ttataccaag aggatttatc ttctggaaaa caaatcttga 1320
agtcagctga tttcctcaaa gagataatat ccactgattc aaacaggctt tctaaattaa 1380
ttcacaaaga ggtggaaaat gctcttaagt tccctatcaa taccggttta gaacgcataa 1440
acactagacg aaatatacag ctttacaatg tagacaatac aagaattctg aaaactacat 1500
atcactcatc aaatattagt aacactgatt acctaaggtt ggctgttgaa gatttctaca 1560
cctgccaatc tatttatcgt gaagaattaa aaggtcttga aaggtgggtg gtagagaata 1620
agttggacca gctcaagttt gctaggcaaa agaccgccta ctgttatttc tctgttgctg 1680
caacactttc gtctcccgaa ttatcagatg cgcgtatttc atgggccaaa aatggcatat 1740
taactacagt agttgatgac ttttttgata tcggtggtac aatcgatgaa ttgaccaacc 1800
tgattcaatg tgttgaaaaa tggaatgtag atgtcgacaa ggattgttgt tcagagcatg 1860
ttcggatttt atttttagca ttaaaagatg caatctgttg gattggagat gaagctttta 1920
aatggcaagc gcgcgatgta actagccatg ttattcaaac ttggttggaa ctaatgaata 1980
gtatgttgag agaagctata tggacaagag atgcttatgt gccaacatta aatgaatata 2040
tggaaaacgc ttacgtgtca tttgcattag gcccgattgt caagccggct atttactttg 2100
tggggcccaa attatcagag gagattgttg aaagctctga atatcataat ctatttaagc 2160
taatgagcac gcagggtcga cttctaaacg atatccatag cttcaagagg gaatttaagg 2220
aaggcaaatt aaacgcggta gcattgcatt tgagtaacgg agaaagtggg aaagtggaag 2280
aagaggttgt ggaggagatg atgatgatga ttaaaaacaa gaggaaagaa ttaatgaaat 2340
taatttttga agaaaatggt agcattgttc ctagagcttg taaagatgca ttttggaaca 2400
tgtgtcacgt gttgaatttt ttttacgcaa acgatgacgg gtttactgga aacacgattc 2460
ttgatactgt gaaggacatc atttacaacc cgttggtgct tgtgaatgaa aatgaagaac 2520
aaaggtaatt ggcctttaaa agatgataat aatatcatgc tcttgacggg ggtactgttg 2580
tagttgtata ataaaggttg tagttgtata ataaaggtaa taggtaatca atagaaagct 2640
taagttatta agtttttccc tcgtgtcaca cacggtgagg ttcttgttaa agcagtttat 2700
tttatgttta gtacgacact tggtggttgt tcgttgttta ttctctaaga ggctttcact 2760
ttgttcttaa aaaaaaaaaa aaaaaaaaaa aa                               2792

<210> 671
<211> 3117
<212> DNA
<213> Stevia rebaudiana

<220> 
<223> kaurene synthase

<400> 671
atttcttttg ctctgattga acacacgatt atctgtattt atgaggattg tagcatattg 60
tttgattttt tatgattatt ttacacttat tctctgtcat ctccgagtct atttggtctg 120
acaagcaata caatatcctc ttagattcac tctacatagg atttaggatg cattgttatt 180
atcctaaaat catcttcatt ttgatccatt gcactgcctg ctccgtaagc ttcttatgat 240
tcggataatt ccggtagaga ataaagttcg gagtatgcat cattgaagtt aatattctgg 300
attgatgttc gttaggaatt ggtacagtag aaaattagct agtttgcttg atttgaccta 360
gaatatagct tcagaaattt gttaatctgt gagcaatgat tcagatgttg ataacttttg 420
gggcaacttc atgttaaaaa acttatatat taaaatgttt tcaagttggt gttgcagtaa 480
atcagcaaac taaacatcaa tgaatctttc actatgcatt gcgtcccctt tgttaaccaa 540
atcaagtcga cccacggctc tgtcagctat tcatacagca tcaacttcac atggtggaca 600
aactaatccc actaatctga tcattgatac aaccaaagaa cggatccaaa aactgtttaa 660
aaatgtagaa atttctgttt cttcatatga cacagcatgg gtagccatgg tcccttctcc 720
aaactcaccc aaatcgcctt gtttccctga gtgtctcaat tggttaatta ataatcagct 780
taatgatggt tcatggggtc ttgttaatca cactcataat cataatcacc cgttgcttaa 840
agattctcta tcttcaacat tagcatgtat tgttgcatta aaaagatgga atgttgggga 900
agatcaaata aataaaggtc taagttttat tgagtcaaat cttgcttcag caactgacaa 960
aagtcaacca tctcccattg gttttgatat catatttcct ggtttgcttg agtatgcgaa 1020
aaacttggac ataaacctcc tttcaaaaca aacagatttt agtttgatgc tacataagag 1080
ggaattggag caaaaaagat gccattcaaa tgagattgat ggatacttgg cgtatatctc 1140
tgaaggactc ggtaatttat atgattggaa tatggtgaag aaatatcaga tgaaaaatgg 1200
ttctgttttc aactcaccat cagcaacagc agctgctttc attaatcatc aaaatcccgg 1260
ttgtcttaat tatttaaatt cacttttgga caagtttggt aatgcagtcc caacagttta 1320
tcctcttgat ttatatatcc ggctttctat ggttgacaca attgaaagat taggaatttc 1380
acaccatttc agagtggaaa ttaaaaatgt tttagatgaa acatacagat gttgggtgga 1440
acgagatgag caaatattca tggatgttgt aacatgtgct ttagcctttc ggttattaag 1500
gatccacggg tataaagtct ccccagatca attggctgaa attactaatg aattagcttt 1560
caaagacgaa tacgcagctc ttgaaacata tcatgcatca cagatattat accaagagga 1620
tttatcttct ggaaaacaaa tcttgaagtc agctgatttc ctcaaaggga tattatccac 1680
tgattcaaac aggctttcta aattaattca caaagaggtg gaaaatgctc ttaagttccc 1740
tatcaatacc ggtttagaac gcataaacac tagacgaaat atacagcttt acaatgtaga 1800
caatacaaga attctgaaaa ctacatatca ctcatcaaat attagtaaca cttattacct 1860
aaggttggct gttgaagatt tctacacctg ccaatctatt tatcgtgaag aattaaaagg 1920
tcttgaaagg tgggtggtac agaataagtt ggaccagctc aagtttgcta ggcaaaagac 1980
cgcctactgt tatttctctg ttgctgcaac actttcgtct cccgaattat cagatgcgcg 2040
tatttcatgg gccaaaaatg gcatattaac tacagtagtt gatgactttt ttgatatcgg 2100
tggtacaatc gatgaattga ccaacctgat tcaatgtgtt gaaaaatgga atgtagatgt 2160
cgacaaggat tgttgttcag agcatgttcg gattttattt ttagcattaa aagatgcaat 2220
ctgttggatt ggagatgaag cttttaaatg gcaagcgcgc gatgtaacta gccatgttat 2280
tcaaacttgg ttggaactaa tgaatagtat gttgagagaa gctatatgga caagagatgc 2340
ttatgtgcca acattaaatg aatatatgga aaacgcttac gtgtcatttg cattaggccc 2400
gattgtcaag ccggctattt actttgtggg gcccaaatta tcagaggaga ttgttgaaag 2460
ctctgaatat cataatctat ttaagctaat gagcacgcag ggtcgacttc taaacgatat 2520
ccatagcttc aagagggaat ttaaggaagg caaattaaac gcggtagcat tgcatttgag 2580
taacggagaa agtgggaaag tggaagaaga ggttgtggag gagatgatga tgatgattaa 2640
aaacaagagg aaagaattaa tgaaattaat ttttgaagaa aatggtagca ttgttcctag 2700
agcttgtaaa gatgcatttt ggaacatgtg tcacgtgttg aatttttttt acgcaaacga 2760
tgacgggttt actggaaaca cgattcttga tactgtgaag gacatcattt acaacccgtt 2820
ggtgcttgtg aatgaaaatg aagaacaaag gtaattggcc tttaaaagat gataataata 2880
tcatgctctt gacgggggta ctgttgtagt tgtataataa aggttgtagt tgtataataa 2940
aggtaatagg taatcaatag aaagcttaag ttattaagtt tttccctcgt gtcacacacg 3000
gtgaggttct tgttaaagca gtttatttta tgtttagtac gacacttggt ggttgttcgt 3060
tgtttattct ctaagaggct ttcactttgt tcttaataag aagtttttat tgtgttg    3117

<210> 672
<211> 2706
<212> DNA
<213> Taxus wallilchiana

<220> 
<223> Taxadiene synthase

<400> 672
gggtaccatg gctcagctct catttaatgc agcgctgaag atgaatgcat tggggaacaa 60
ggcaatccac gatccaacga attgcagagc caaatctgag ggccaaatga tgtgggtttg 120
ctccaaatca gggcgaacca gagtaaaaat gtcgagagga agtggtggtc ctggtcctgt 180
cgtaatgatg agcagcagca ctggcactag caaggtggtt tccgagactt ccagtaccat 240
tgtggatgat atccctcgac tctccgccaa ttatcatggc gatctgtggc accacaatgt 300
tatacaaact ctggagacac catttcgtga gagttctact taccaagaac gggcagatga 360
gctggttgtg aaaattaaag atatgttcaa tgcgctcgga gacggagata tcagtccgtc 420
tgcatacgac actgcgtggg tggcgagggt ggcgaccatt tcctctgatg gatctgagaa 480
gccacggttt cctcaggctc tcaactgggt tttcaacaac cagctccagg atggatcgtg 540
gggtatcgaa tcgcacttta gtttatgcga tcgattgctt aacacgacca attctgttat 600
cgccctctcg gtttggaaaa cagggcacag ccaagtagaa caaggtactg agtttattgc 660
agagaatcta agattactca atgaggaaga tgagttgtcc ccggatttcg aaataatctt 720
tcctgctctg ctgcaaaagg caaaagcgtt ggggatcaat cttccttacg atcttccatt 780
tatcaaatat ttgtcgacaa cacgggaagc caggcttaca gatgtttctg cggcagcaga 840
caatattcca gccaacatgt tgaatgcgtt ggagggtctt gaggaagtta tggactggaa 900
gaagattatg aggtttcaaa gtaaagatgg atctttcctg agctcccctg cttccactgc 960
ctgtgtactg atgaatacag gggacgaaaa atgtttcact tttctcaaca atctgctggt 1020
caaattcggc ggctgcgtgc cctgtatgta ttccatcgat ctgctggaac gcctttcgct 1080
ggttgataac attgagcatc tcggaatcgg tcgccatttc aaacaagaaa tcaaagtagc 1140
tcttgattat gtctacagac attggagtga aaggggcatc ggttggggca gagacagcct 1200
cgttccagat ctcaacacaa cagccctcgg cctgcgaact cttcgcacgc acggatacga 1260
tgtttcttca gatgttttga ataatttcaa agatgaaaac gggcggttct tctcctctgc 1320
gggccaaacc catgtggaat tgagaagcgt ggtgattctt ttcagagctt ccgaccttgc 1380
atttcctgac gaaggagcta tggacgatgc tagaaaattt gcagaaccat atcttagaga 1440
cgcacttgca acaaaaatct caaccaatac aaaactattc aaagagattg agtacgtggt 1500
ggagtaccct tggcacatga gtatcccacg ctcagaagcc agaagttata ttgattcgta 1560
tgatgacgat tatgtatggg agaggaagac tctatataga atgccatctt tgagtaattc 1620
aaaatgttta gaattggcaa aattggactt caatatcgta caatctttgc atcaagagga 1680
gttgaagctt ctaacaagat ggtggaagga atccggcatg gcagatataa atttcactcg 1740
acaccgagtg gcggaggttt atttttcatc agctacattt gaacccgaat attctgccac 1800
tagaattgcc ttcacaaaaa ttggttgttt acaagtcctt tttgatgata tggctgacat 1860
ctttgcaaca ctagatgaat tgaaaagttt cactgaggga gtaaagagat gggatacatc 1920
tttgctacat gagattccag agtgtatgca aacttgcttt aaagtttggt tcaaattaat 1980
tgaagaagta aataatgatg tggttaaggt acaaggacgt gacatgctcg ctcacataag 2040
aaaaccctgg gagttgtact tcaattgtta tgtacaagaa agggagtggc ttgacgctgg 2100
gtatatacca acttttgaag agtacttaaa gacttatgct atatcagtag gccttggacc 2160
gtgtacccta caaccaatac tactaatggg tgagcttgtg aaagatgatg ttgttgagaa 2220
agtgcactat ccctcaaata tgtttgagct tgtatccttg agttggcgac taacaaacga 2280
caccaaaaca tatcaggctg aaaaggctcg aggacaacaa gcctcaggca tagcatgcta 2340
tatgaaggat aatctaggag caactgagga agatgccatc aagcacatat gtcgtgttgt 2400
tgaccgggcc ttgaaagaag caagctttga atatttcaaa ccatccaatg atatcccaat 2460
gggttgcaag tcctttattt ttaaccttag attgtgtgtc caaatctttt acaagtttat 2520
agatgggtac ggaatcgcca atgaggagat taaggattat ataagaaaag tttatattga 2580
tccaattcaa gtatgatata tcatgtaaaa cctttttttc ataataaatt gaattattat 2640
tgtattggca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2700
aaaaaa                                                            2706

<210> 673
<211> 1674
<212> DNA
<213> Vitis vinifera

<220> 
<223> (-)-germacrene D synthase

<400> 673
atgtctgttc agtcttcagg ggtacttctt gctccatcta aaaacctcag ccctgaggtt 60
ggccggcgct gtgcaaattt tcatcccagc atttgggggg atcatttcct ttcttatgct 120
tctgaattca caaacactga cgatcatttg aagcaacatg tccaacagct gaaagaagaa 180
gtgaggaaga tgctaatggc tgctgatgat gattctgcgc aaaagttgct cttgattgat 240
gcaatccaac ggctgggagt tgcttaccat tttgagagtg agattgatga agtattaaaa 300
cacatgttcg atggttccgt tgtctctgct gaagaagatg tttatactgc ttctctccga 360
tttcggttac taagacaaca agggtaccat gtctcatgtg atttattcaa caatttcaag 420
gataatgaag gaaacttcaa ggaatccctc agcagcgatg tgcggggaat gttaagcttg 480
tatgaagcca cacatttcag ggtgcatgga gaagatatat tagatgaagc acttgctttc 540
actaccactc accttcagtc cgccacaaag cactcttcaa atcctcttgc tgaacaagta 600
gttcatgccc tgaagcagcc catccgaaag gggttaccta ggctagaggc caggcattat 660
ttttctgtgt accaagcaga tgattctcat aacaaagctc tgctgaagct agcaaagttg 720
gatttcaacc tattacagaa attacaccag aaggagctaa gtgacatttc cgcgtggtgg 780
aaagatttag actttgcaca caagcttcct tttgcaagag atcgggtggt ggaatgctac 840
ttttggatat tgggggtgta ctttgagccc cagtttttct tcgctagaag gattctcact 900
aaagtaatag ccatgacctc tattattgat gacatctatg acgtgtatgg tacacttgaa 960
gaactcgagc tcttcaccga agcagttgag aggtgggata tcagtgccat agatcaactg 1020
ccagagtaca tgagagtgtg ttatcaagca ctcttatatg tgtacagtga aattgaggaa 1080
gaaatggcca aggaaggaag atcgtatcgg ctctactatg caaaagaagc aatgaaaaat 1140
caagtaagag catactatga ggaagccaaa tggcttcaag tgcaacaaat tccaaccatg 1200
gaggagtaca tgcctgtggc gttagttacc tctgcatact caatgctggc gaccacatcg 1260
tttgttggaa tgggagatgc tgtgacaaaa gaaagcttcg attggatttt cagtaagcct 1320
aagattgtaa gggcttcagc catagtttgc aggctcatgg atgatatggt tttccacaag 1380
tttgagcaga agagaggaca tgttgcctca gctgttgaat gttacatgaa gcaacatggt 1440
gcgtcggagc aggaaacgcc caacgaattt ccccaaccag ttagagaagc atggaaggat 1500
atcaatgaag agtgcctcat cccaacagct gtcccaatgc ccatcctcat gcgagttcta 1560
aatctcgcac gtgttataga tgttatatac aagaatgaag atggctatac tcattttggg 1620
gctgttttaa aggatttcgt aacttccatg ctaattgatc ctgtgccaat atga       1674

<210> 674
<211> 1671
<212> DNA
<213> Vitis vinifera

<220> 
<223> (+)-valencene synthase

<400> 674
atgtctactc aagtctcagc atcttctcta gcccagattc cccaacccaa aaatcgtcct 60
gtggcaaact ttcaccccaa catttggggt gaccaattta tcacctacac tcctgaagac 120
aaggttactc gtgcctgcaa agaggagcag attgaggatc tgaaaaagga agtgaaaagg 180
aaattaacgg ctgctgctgt tgctaaccct tcccaattgc tgaacttcat tgatgcagtg 240
caacgtcttg gggtggcata ccactttgag caagagatag aagaagcatt acaacatatt 300
tgtaatagtt ttcatgactg caatgatatg gatggtgatc tctacaatat tgctcttgga 360
tttcgactac taaggcaaca agggtacact atttcatgtg atatattcaa caagtttacg 420
gatgaacgag gtagattcaa ggaagctttg atcagcgatg taagaggcat gctaggcttg 480
tatgaagctg cacatctgag ggttcatgga gaggacatac ttgcaaaagc acttgctttc 540
accaccactc atctcaaggc catggtagaa agtttaggat atcatcttgc agaacaagtt 600
gctcatgccc tgaaccggcc cattagaaaa ggtttggaga ggctagaggc aagatggtat 660
atatctgtct accaagatga agctttccat gataaaactt tactagagct agcaaaatta 720
gatttcaatc tagtgcagtc actgcacaag gaagagctaa gcaatcttgc aaggtggtgg 780
aaagaattag actttgctac aaagttacct tttgcacgag acagattggt tgaaggctac 840
ttttggatgc atggggtgta ttttgagccc caatacttac ggggtagacg aattctaacc 900
aaagtaattg ccatgacatc cattctagat gatatccatg atgcatatgg cacacctgaa 960
gaactcaagc tcttcataga agccattgag agatgggata ttaacagcat aaatcagctt 1020
ccagaataca tgaaactctg ctatgtggca ctcttagatg tgtacaaaga aatcgaggaa 1080
gagatggaga aagaaggaaa ccaatatcgg gttcactatg ccaaagaagt aatgaagaat 1140
caagttcgag cttactttgc cgaggccaaa tggttacatg aagaacacgt accagcattt 1200
gaagagtaca tgcgtgttgc actagcaagc tctggatact gcctgcttgc aaccacgtcc 1260
tttgtgggaa tgggagaaat agcaacaaag gaggcctttg attgggtgac cagcgatcct 1320
aagattatgt catcttcaaa tttcattacg aggctcatgg atgacatcaa atcacataag 1380
tttgagcaaa agagagggca tgtggcctca gctgttgaat gttacatgaa gcaatatggt 1440
gtctctgagg aacaagtata cagtgaattt caaaagcaaa ttgagaatgc atggctggat 1500
attaaccagg aatgcctcaa acctactgct gtttcaatgc ctctccttgc tcgtcttctc 1560
aatcttacac gaaccatgga tgtcatttac aaagagcaag attcgtacac acatgttggg 1620
aaagtgatga gggataacat tgcgtctgtc ttcatcaacg ctgtaatata a          1671

<210> 675
<211> 1671
<212> DNA
<213> Vitis vinifera

<220> 
<223> (+)-valencene synthase

<400> 675
atgtctactc aagtctcagc atcttctcta gcccagattc cccaacccaa aaatcgtcct 60
gtggcaaact ttcaccccaa catttggggt gaccaattta tcacctacac tcctgaagac 120
aaggttactc gtgcctgcaa agaggagcag attgaggatc tgaaaaagga agtgaaaagg 180
aaattaacgg ctgctgctgt tgctaaccct tcccaattgc tgaacttcat tgatgcagtg 240
caacgtcttg gggtggcata ccactttgag caagagatag aagaagcatt acaacatatt 300
tgtaatagtt ttcatgactg caatgatatg gatggtgatc tctacaatat tgctcttgga 360
tttcgactac taaggcaaca agggtacact atttcatgtg atatattcaa caagtttacg 420
gatgaacgag gtagattcaa ggaagctttg atcagcgatg taagaggcat gctaggcttg 480
tatgaagctg cacatctgag ggttcatgga gaggacatac ttgcaaaagc acttgctttc 540
accaccactc atctcaaggc catggtagaa agtttaggat atcatcttgc agaacaagtt 600
gctcatgccc tgaaccggcc cattagaaaa ggtttggaga ggctagaggc aagatggtat 660
atatctgtct accaagatga agctttccat gataaaactt tactagagct agcaaaatta 720
gatttcaatc tagtgcagtc actgcacaag gaagagctaa gcaatcttgc aaggtggtgg 780
aaagaattag actttgctac aaagttacct tttgcacgag acagattggt tgaaggctac 840
ttttggatgc atggggtgta ttttgagccc caatacttac ggggtagacg aattctaacc 900
aaagtaattg ccatgacatc cattctagat gatatccatg atgcatatgg cacacctgaa 960
gaactcaagc tcttcataga agccattgag agatgggata ttaacagcat aaatcagctt 1020
ccagaataca tgaaactctg ctatgtggcg ctcttagatg tgtacaaaga aatcgaggaa 1080
gagatggaga aagaaggaaa ccaatatcgg gttcactatg ccaaagaagt aatgaagaat 1140
caagttcgag cttactttgc cgaggccaaa tggttacatg aagaacacgt accagcattt 1200
gaagagtaca tgcgtgttgc actagcaagc tctggatact gcctgcttgc aaccacgtcc 1260
tttgtgggaa tgggagaaat agcaacaaag gaggcctttg attgggtgac cagcgatcct 1320
aagattatgt catcttcaaa cttcattacg aggctcatgg atgacatcaa atcacataag 1380
tttgagcaaa agagagggca tgtgacctca gctgttgaat gttacatgaa gcaatatggt 1440
gtctctgagg aacaagtata cagtgaattt caaaagcaaa ttgagaatgc atggctggat 1500
attaaccagg aatgcctcaa acctactgct gtttcaatgc ctctccttgc tcgtcttctc 1560
aattttacac gaaccatgga tgtcatttac aaagagcaag attcgtacac acatgttggg 1620
aaagtgatga gggataacat tgcgtctgtt ttcatcaacg ctgtaatata a          1671

<210> 676
<211> 1644
<212> DNA
<213> Zea diploperennis

<220> 
<223> (E)-beta-caryophyllene synthase

<400> 676
atggcagctg atgaggcaag atccgtcagc aggctccata gtgaggagga catgcatggc 60
aagcaccact ccactctatg gggtgacttc ttccttcacc atgtcccatg tcgtccagga 120
cagtatttga ttatgaagga taaggtcaaa ataatgaagg aggaggtgaa gaaaatgtta 180
ctggatgttg gatcctctga tttgtctcat aagttagact gcattaatac actagaacgg 240
cttggattgg attaccacta taccaaggag attgatgaat taatgtgcaa tgtcttcgaa 300
gctagggatc aagatcttga tcttactaca acatcacagc ttttctattt gcttaggaag 360
catggatatc atgtttcttc tgatgtattt ttgaagttca gagatgataa aggagatatc 420
gtaacagatg atgcaaggtg tttactaaga atgtacgaag cggcacatgt tagagtgaac 480
ggtgaagaaa ttcttgacaa tattctcatt cacaccaaga gacaacttca atgtattgta 540
gacgatctcg aaccaacact gcaagaagaa gtgagatatg cattggagac acctcttttc 600
agaagactca acagagtaca ggccaggcaa ttcatctcaa catacgagaa aagcactacg 660
cgtaacaata tgctcctgga gttctcaaag ttagacttca acatcttgct caccctatac 720
tgtgaggagc taaaagatct tacgctgtgg tggaaagagt tccaagcaca ggctaacaca 780
gcaatctatg cacgagatag gatggtggag atgcatttct ggatgatggg agtctttttt 840
gagccccaat actcctattc acgaaagatg ctcacacaat tgtttatgat cgtgtctgta 900
ctcgatgact tgtatgacag ccattgcacc acagaggaag gcaacacctt cactgcagca 960
ttacaaaggt gggatgaaga aggcgtggaa caatgcccaa catacttgag gactttgtat 1020
acaaatatac gtgccaccgt aaaagccatc gaggaggact tgaatcttca aaacaacaaa 1080
catgcaaagt tggtaaaagg actgataatc gacatggcca tgtgctataa tgccgagaca 1140
gaatggcgtg acaagaaata tgtgccagcc accgttgatg aacatctgaa aatttcagca 1200
cgcagcagtg gctgtatgca cttggtgagc caggggttca tttcgatggg agatgtggca 1260
actagcgagg ccctcgagtg ggcctctacc tatcccaaaa tcgttcgagc tgtctgtatc 1320
attgcacgcc tcgctaacga tataatgtcg tacaagcgag aagcatcaaa caatactatg 1380
gtgtctacag tgcaaacttg tgcaaaagaa tacggcacca ccacagtaga acaggccata 1440
gaaaagatca gagagctgat cgaggaagcg tggatggaca tcacccatga gtgcctcaga 1500
cagccacagc cgaaggctct tctagagagg gcggtcaacc tggctcgtac aatggatttt 1560
ctgtacaaag atgtggatgg atacacagat tcacggagta tcaaaggcat attggattca 1620
ttgtatgtgc atctaataga ctaa                                        1644

<210> 677
<211> 1644
<212> DNA
<213> Zea luxurians

<220> 
<223> (E)-beta-caryophyllene synthase

<400> 677
atggcagctg atgaggcaag atccgtcagc aggctccacg gtgaggagga catgcatggc 60
aagcaccact ccactctatg gggtgacttc ttccttcacc atgtcccatg tcgtccagga 120
cagtatttga ttatgaagga taacgtcgaa ataatgaagg aggaggtgaa gaaaatgtta 180
ctggatgttg gatcctctga tttgtctcat aagttagact gcattgatac actaggacgg 240
cttggattgg attaccacta taccaaggag attgatgaat taatgtgcaa tgtcttcgaa 300
gctatggatc aagatcttga tcttactaca acatcgcagc ttttctattt gcttaggaag 360
catggatatc atatttcttc tgatgtattt ttgaagttca gagatgataa aggagatatt 420
gtaacaaatg atgcaaggtg tttactaagg atgtacgaag cggcacatgt tagagtgaac 480
ggtgaagaaa tacttgacaa tattctcatt cacaccaaga gacagcttca atgtattgta 540
gacgatctcg aaccaacact gcaagaagaa gtgagatatg cattggagac acctcttttc 600
agaagactca acagagtaca ggccaggcaa ttcatctcaa catacgagaa aagcactacg 660
cgtaacaata tgctcctgga gttctcaaag ttagacttca acatcttgct caccctatac 720
tgtgaggagc taaaagatct tacgctgtgg tggaaagagt tccaagcaca ggctaacatg 780
acaatctatg cacgagatag gatggtggag atgcatttct ggatgatggg agtcttcttt 840
gagccccaat actcctattc acgaaagatg ctcacacgat tgtttatgat cgtgtctgta 900
ctcgatgact tgtatgacag ccattgcacc acagaggaag gcaacgcctt cactgcagca 960
ttacaaaggt gggatgaaga aggcgtggag caatgcccaa catacttgag gactttgtat 1020
acaaatatac gtgccaccgt aaaagccatc gaggaggact tgaatcttca aaacaacaaa 1080
catgcaaagt tggtaaaagg actgataatc gacatggcca tgtgctataa tgccgagaca 1140
gaatggcgtg acaagaaata tgtgccagcc accgttgatg aacatctgaa aatttcagca 1200
cgcagcagtg gctgtatgca cttggtaagc caggggttca tttcgatggg agatgtggca 1260
actagcgagg ccctcgagtg ggcctctacc tatcccaaaa tcgttcgagc tgtctgtatc 1320
attgcacgcc tcgctaatga tataatgtcg tacaagcgag aagcatcaaa caatactatg 1380
gtgtctacag tgcaaacttg tgcaaaagaa tacggcacca ccacagtaga acaggccata 1440
gaaaagatca gagagctgat cgaggaagcg tggatggaca tcacccatga gtgcctcaga 1500
cagccacagc cgaaggctct tctagagagg gcggtcaacc tggctcgtac aatggatttt 1560
ctgtacaaag atgtggatgg atacacagat tcacggagta tcaaaggcat attggattca 1620
ttgtatgtgc atctaataga ctaa                                        1644

<210> 678
<211> 1644
<212> DNA
<213> Zea mays

<220> 
<223> (E)-beta-caryophyllene synthase

<400> 678
atggcagctg atgaggcaag atccgtcagc aggctccaca gtgaggagga catgcatggc 60
aagcaccact ccactctatg gggtgacttc ttccttcacc atgtcccatg tcgtccagga 120
caatattcaa ttatgaagga taacgtcaaa ataatgaagg aggaggtgaa gaaaatgtta 180
ctggatgttg gatcctctga tttgtctcat aagttagaat gcattgatac actagaacgg 240
cttggattgg attaccacta taccaaggag attgatgaat taatgtgcaa tgtcttcgaa 300
gctagggatc aagatcttga tcttactaca acatcacaac ttttctattt gcttaggaag 360
catggatatc atgtttcttc tgatgtattt ttgaagttcg gagatgataa aggagatatc 420
gtaacagatg atgcaaggtg tttactgaga atgtacgaag cggcacatgt tagagtgaat 480
ggtgaagaaa tacttgacaa tattctcatt cacaccaaga gacagcttca atgtattgta 540
gacgatctcg aaccaacact gcaagaagaa gtgagatatg cattggagac acctcttttc 600
agaagactca acagagtaca ggccaggcaa ttcatctcaa catacgagaa aagcactatg 660
cgtaacaata tgctcctgga gttctcaaag ttagacttca acatcttgct caccctatac 720
tgtgaggagc taaaagatct tacgatgtgg tggaaagagt tccaagcaca ggctaacacg 780
acaatctatg cacgagatag gatggtggag atgcatttct ggatgatggg agtcttcttt 840
gagccccaat actcctattc acgaaagatg ctcacacagt tgtttatgat cgtgtctgta 900
ctcgatgact tgtatgacag ccattgcacc acagaggaag gcaatgcctt cactgcagca 960
ttacaaaggt gggacgaaga aggcgtggag caatgtccaa catacttgag gactttgtat 1020
acaaatatac gtgccaccgt aaaagccatc gaggaagact tgaatcttca aaacaacaaa 1080
catgcaaagt tggtaaaagg actgataatc gacatggcca tgtgctataa tgccgagaca 1140
gaatggcgtg acaagaaata tgtgccagcc accgttgatg aacatctgaa aatttcagca 1200
cgcagcagtg gttgtatgca cttggtgagc caggggttca tttcgatggg agatgtggca 1260
actagcgagg ccctcgagtg ggcctctacc tatcccaaaa tcgttcgagc tgtctgtatc 1320
attgcacgcc tcgctaacga tataatgtcg tacaagcgag aagcatcaaa caatactatg 1380
gtgtctacag tgcaaacttg tgcaaaggaa tacggcacca ccacagtaga acaggccata 1440
gaaaagatca gagagttgat cgaggaagcg tggatggaca tcacccatga gtgcctcaga 1500
cagccacagc cgatggctct tctcgagagg gcggtcaacc tggctcgtac aatggatttt 1560
ctgtacaaag atgtggatgg atacacagat tcatggagta tcaaaggcat attggattca 1620
ttgtatgtgc atctaataga ctaa                                        1644

<210> 679
<211> 1647
<212> DNA
<213> Zea mays

<220> 
<223> (-)-beta-macrocarpene synthase

<400> 679
atggctgccc caacactaac tgcagatggt cctcgcctcg gccagcagga gatgaagaag 60
atgtctccct ccttccatcc aactctgtgg ggagatttct ttctttctta cgaggctccg 120
accgaggcac aggaagctca aatgagagaa aaggctgcag tgctaaagga agaagtgaga 180
aacatgatta aaggttcaca tgatgtgcca gaaatagtgg accttattat caccctgcag 240
cgactaaatc tggactacca ctacgaggat gagataaatg aaaagttgac tgttgtttac 300
aaatccaatt atgatggtgg taatttggac ttagtttcac gtcgattcta tcttctgcgt 360
aaatgtggct acgatgtttc atctgatgta ttcctaaaat tcaaagacca acttgggaat 420
tttgttgagg ctgataccag gagcttgtta agcttataca atgcagcatt cctgaggatt 480
catggagaga cagtgcttga cgaggcaatt tcttttacta tgagagttct tcaagataga 540
ttagaacatt tggaatcgcc attagcagag gaagtgtctt ctgctcttga cacaccactt 600
tttcgaaggg ttggaacttt ggaaatgaag gattacattc ctatctacga aaaggacgct 660
aaacaaaata aatcaatatt agagtttgcg aaactaaact tcaacctttt acaacttcgt 720
tattcatcag agctaaaaga gtgcacaacc tggtggaaag aacttcgcgt cgaatcaaac 780
ttgagtttcg tcagggatag gatagtagag gtgtactttt ggatgagtgg gggatgctat 840
gatcctcaat attctcattc tcgaattata cttacaaaga tagttgcttt catcacgatt 900
ctagatgata cccttgactc acatgctact tcttgtgaga gtatgcaact tgcagaagca 960
atcgaaaggt gggatgaaag tgcagtctct ctactcccag aatacatgaa ggatttctac 1020
atgtatttgt tgaagacatt ttcatcgttt gagaatgagt taggaccaga caagagctac 1080
cgagtgttct acttaaaaga agcggtgaag gaattagttc gggaatatac caaggaaata 1140
aaatggcgtg atgaggatta tgtgcccaaa acattgaaag agcaccttaa agtttcactc 1200
ataagcattg gaggcactct ggtgctatgt tctgcgtttg ttggaatggg tgatgtagta 1260
acaaagaaga tcatgaaatg ggttatgagt gatgctgaac ttgttaagtc ttttggtata 1320
tttgtacggc tctccaatga tattgtatca accaagcgtg aacaaagaga gaagcattgt 1380
gtctccactg ttcagtgtta catgaagcag catgaaataa caatggatga agcgtgtgag 1440
cagataaaag aacttacaga agattcatgg aagttcatga ttgaacaagg ccttgcacta 1500
aaagaatacc cgataattgt gccacgaacg gtactagagt ttgcacgaac tgtagactac 1560
atgtacaagg aagctgataa gtacactgtc tcacatacaa tcaaagacat gttaacgtcg 1620
ctttatgtga agccggtact catgtga                                     1647

<210> 680
<211> 1742
<212> DNA
<213> Zea mays

<220> 
<223> (-)-beta-macrocarpene synthase

<400> 680
cgactggagc acgaggacac tgacatggac tgaaggagta gaaaatccca tatctcacta 60
ccaaaagcat ccgatcccac acatctgcta aaaggatggc tgccccaaca ctaactgcag 120
atggtcctcg cctcggccag caggagatga agaagatgtc tccctccttc catccaactc 180
tgtggggaga tttctttctt tcttacgagg ctccgaccga ggcacaggag gctcaaatga 240
gagaaaaggc tgcagtgcta aaggaagaag tgagaaacat gattaaaggt tcacatgatg 300
tgccagaaat agtggacctt attatcaccc tgcagcgact aaatctggac taccactacg 360
aggatgagat aaatgaaaag ttgactgttg tttacaaatc caattatgat ggtggtaatt 420
tggacttagt ttcacgtcga ttctatcttc tgcgtaaatg tggctacgat gtttcatctg 480
atgtattcct aaaattcaaa gaccaacttg ggaattttgt tgaggctgat accaggagct 540
tgttaagctt atacaatgca gcattcctga ggattcatgg agagacagtg cttgacgagg 600
caatttcttt tactatgaga gttcttcaag atagattaga acatttggaa tcgccattag 660
cagaggaagt gtcttctgct cttgacgcac cactttttcg aagggttgga actttggaaa 720
tgaaggatta cattcctatc tacgaaaagg acgctaaaca aaataaatca atattagagt 780
ttgcgaaact aaacttcaac cttttacaac ttcgttattc atcagagcta aaagagtgca 840
caacctggtg gaaagaactt cgcgtcgaat caaacttgag tttcgtcagg gataggatag 900
tagaggtgta cttttggatg agtgggggat gctatgatcc tcaatattct cattctcgaa 960
ttatacttac aaagatagtt gctttcatca cgattctaga tgataccctt gactcacatg 1020
ctacttcttg tgagagtatg caacttgcag aagcaatcga aaggtgggat gaaagtgcag 1080
tctctctact cccagaatac atgaaggatt tctacatgta tttgttgaag acattttcat 1140
cgtttgagaa tgagttagga ccagacaaga gctaccgagt gttctactta aaagaagcgg 1200
tgaaggaatt agttcgggaa tataccaagg aaataaaatg gcgtgatgag gattatgtgc 1260
ccaaaacatt gaaagagcac cttaaagttt cactcataag cattggaggc actctggtgc 1320
tatgttctgc gtttgttgga atgggtgatg tagtaacaaa gaagatcatg aaatgggtta 1380
tgagtgatgc tgaacttgtt aagtcttttg gtatatttgt acggctctcc aatgatattg 1440
tatcaaccaa gcgtgaacaa agagagaagc attgtgtctc cactgttcag tgttacatga 1500
agcagcatga aataacaatg gatgaagcat gtgagcagat aaaagaactt acagaagatt 1560
catggaagtt catgattgaa caaggccttg cactaaaaga atacccgata attgtgccac 1620
gaacggtact agagtttgca cgaactgtag actacatgta caaggaagct gataagtaca 1680
ctgtctcaca tacaatcaaa gacatgttaa cgtcgcttta tgtgaagccg gtactcatgt 1740
ga                                                                1742

<210> 681
<211> 1647
<212> DNA
<213> Zea mays

<220> 
<223> (-)-beta-macrocarpene synthase

<400> 681
atggctgccc caacactaac tacagatggt cctcgcctcg gccagcagga gatgaagaag 60
atgtctccct ccttccatcc aactctgtgg ggagatttct ttctttctta cgaggcgccg 120
accgaggcac aggaagctga aatgcgacaa agggctgaag tgctgaggga agaagtgaga 180
aacatgatta aaggttcaca tgatgtgcca gaaatagtgg accttattat caccctgcag 240
cgactaaatc tggactacca ctacgaggat gagataaatg aaaagttggc tgttgtttac 300
aactccaatt atgatggtgg taatttggac ttagtttcac gccgattcta tcttctgcgt 360
aaatgtggct atcatgtttc atccgatgta tttctaaatt tcaaagacca atatggaaat 420
tttattgagg tagataccag gagcttgtta agcttataca atgcagcata cctgaggatt 480
catggagaga cagtgcttga tgaggcaatt tcttttacta cgagatgcct tcaagataga 540
ttagaacatt tggaatcacc aatagcagag gaagtgtcgt ctgcccttga taccccactt 600
tttagaaggg ttggaacttt ggaaatgaag gattacattc ctatctacga aaaggacgct 660
aaacaaaaca aatcaatatt agagtttgcg aaactgaact tcaaccttct acagcttctt 720
tattcatcag agctcaaaga gtgcacaacc tggtggaaag aactccgcgt cgaatcaaac 780
ttgagttttg tgagggatag aatagtagag gtgtactttt ggatgagtgg gggatgctat 840
gatcctcaat attctcattc tcgaattata cttacaaaga ttgttgcttt catcacgatt 900
ctagatgata cccttgactc acatgctaat tcttatgaga gtatgcaact tgcagaagca 960
gtcgaaaggt gggatgaaag tgcagtctca ctactcccag aatacatgaa ggatttctac 1020
atgtatttgt tgaagacatt ttcatcgttt gagaatgagt taggaccaga caagagctac 1080
cgagtgttct acttaaaaga agcggtgaag gaattagttc gggaatatac caaggaaata 1140
aaatggcgtg atgaggatta tgtccccaaa acattgaaag aacacctaaa agtttcactc 1200
ataagcattg gaggtacact ggtgctgtgt tccgcgtttg ttggaatggg tgatgtagta 1260
acaaagaaga tcatggaatg ggttatgagt gatgctgaac ttgttaagtc ttttggtata 1320
tttgtacggc tctccaatga tattgtatca accaagcgtg aacaaagaga gaagcattgt 1380
gtctccactg ttcagtgtta catgaagcag catgaactaa caatggatga agcatgtgag 1440
cagataaaag aacttacaga agattcatgg aagttcatga ttgaacaagg ccttgcacta 1500
aaagaatacc cgataattgt gccacgaacc gtactagagt ttgcacgaac tgtagactac 1560
atgtacaagg aagctgataa gtacactgtc tcccatacaa tcaaagacat gttaacatcg 1620
ctttatgtga agccggtact catgtga                                     1647

<210> 682
<211> 1644
<212> DNA
<213> Zea mays

<220> 
<223> (E)-beta-caryophyllene synthase

<400> 682
atggcagctg atgaggcaag atccgtcagc aggctccaca gtgaggagga catgcatggg 60
aagcaccact ccactctatg gggtgacttc ttccttcacc atgtcccatg tcgtccagga 120
cagtatttga ttatgaagga taacgtcgaa ataatgaagg aggaggtgaa gaaaatgtta 180
ctggatgttg gatcctctga tttgtctcat aagttagact gcattgatac actagaacgg 240
cttggactgg attaccacta taccaaggag attgatgaat taatgtgcaa tgtcttcgaa 300
gctagggatc aagatcttga tcttactaca acatcacagc ttttctattt gcttaggaag 360
catggatatc atatttcttc tgatgtattt ttgaagttca gagatgataa aggagatatc 420
gtaacaaatg atgcaaggtg tttactgagg atgtacgaag cggcacatgt tagagtgaac 480
ggtgaagaaa tacttgacaa tattctcatt cacaccaaga gacaacttca atgtattgta 540
gatgatctcg aaccaacact gcaagaagaa gttagatatg cattggagac acctcttttc 600
agaagactca acagagtaca ggccaggcaa ttcatctcaa catacgagaa aagcactacg 660
cgtatcaata tgctcctgga gttctcaaaa ttagacttca acatcttgct caccctatac 720
tgtgaggagc taaaagatct tacgctgtgg tggaaagagt tccaagcaca ggctaacacg 780
acaatctatg cacgagatag gatggtggag atgcatttct ggatgatggg agtcttcttt 840
gagccccaat actcctattc acgaaagatg ctcacgcagt tgtttatgat cgtgtctgta 900
ctcgatgact tgtatgacag ccattgcacc acagaggaag gcaacgcctt cactgcagca 960
ttacaaaggt gggatgaaga aggcgtggag caatgcccaa catacttgag gactctgtat 1020
acaaatatac gtgccaccat aaaagccatc gaggaggact tgaattttca aaacaacaaa 1080
catgcaaagt tggtaaaagg actgataatc gacatggcca tgtgctataa tgccgagaca 1140
gaatggcgtg acaagaaata tgtgccagcc accgttgatg aacatctgaa aatttcagca 1200
cgcagcagtg gctgtatgca cttggtgagc caggggttca tttcgatggg agatgtggca 1260
actagcgagg ccctcgagtg ggcctctacc tatcccaaaa tcgttcgagc tgtctgtatc 1320
attgcacgcc tcgctaatga tataatgtcg tacaagcgag aagcatcaaa caatactatg 1380
gtgtctacag tgcaaacttg tgcaaaagaa tacggcacca ccacagtaga acaggccata 1440
gaaaagatca gagagctgat cgaggaagcg tggatggaca tcacccatga gtgcctcaga 1500
cagccacagc cgaaggctct tctagagagg gcggtcaacc tggctcgtac aatggatttt 1560
ctgtacaaag atgcggatgg atacacagat tcacggagta tcaaaggcat attggattca 1620
ttgtatgtgc atctaataga ctaa                                        1644

<210> 683
<211> 1773
<212> DNA
<213> Zea mays

<220> 
<223> (E,E)-farnesol synthase

<400> 683
atggccatgc cagtgaagct gactcctgcc tccctctcgc tgaaggcggt ctgctgccgc 60
ttcagctccg gagggcatgc gctgcgcttc ggctcgtcgc taccgtgctg gaggaggacg 120
ccgacgcaac ggagcacgtc gtcgtctacg acgcgccctg cggctgaggt tagctctggc 180
aaaagcaagc agcacgatca agaagcatcg gaggctacga taagacagca gctccagcta 240
gtcgatgtgc ttgagaacat ggggatttct cggcattttg ctgctgaaat caaatgcatc 300
cttgacagga catacagaag ttggttacag agacatgagg aaattatgct ggacacaatg 360
acctgtgcga tggcatttcg tattctaagg ttgaatggat acaatgtctc ttctgatgag 420
ttgtatcatg ttgttgaagc ttccggactc cataattcac ttggaggata tctcaatgat 480
acaagaacct tgttagaatt acacaaggcc tcgacagtta gtatctctga agatgagtct 540
atcctggata gcataggctc aaggtcacgt accttactga gggaacaact agagtctggt 600
ggtgctctac gaaaaccttc actctttaaa gaggtggaac atgctctgga cggtcccttc 660
tacaccacat tggaccgtct acaccatagg tggaacatcg aaaatttcaa tattatagag 720
cagcacatgc tagagacacc atacttgtca aatcaacata ccagtagaga tattctagcg 780
ttgagtatta gagacttcag ttcctctcag tttacttacc agcaagaact tcaacatctt 840
gaaagctggg tgaaagagtg caggttagac cagctacaat ttgcgcgaca gaagttggca 900
tacttctact tgtctgctgc tggcaccatg ttctctcctg agctgtctga tgctcgaact 960
ttgtgggcca aaaatggtgt gctcacaact attgttgacg acttctttga tgttgcggga 1020
tcaaaagaag aacttgaaaa ccttgtcatg ttggttgaga tgtgggacga gcatcacaaa 1080
gttgagttct actcagaaca agtagagatt atattttctt caatttatga ctcagttaac 1140
caacttggtg aaaaggcttc tttggtacaa gaccgcagta ttaccaaaca cctagtagaa 1200
atatggttgg atttgctaaa gtctatgatg acagaggtag agtggcgttt gagcaaatat 1260
gtgccaacag agaaggaata catgataaat gcatctttaa tatttggact aggccccatt 1320
gtattgccag cattatattt tgttgggcca aagatctcag agtctattgt taaagatcca 1380
gaatatgatg aattgttcaa actgatgagc acatgtggtc gcctcttgaa tgatgttcag 1440
acttttgaga gggagtacaa cgagggcaag ttgaatagtg tttctctcct cgttcttcat 1500
ggtggcccca tgtccatatc agacgccaaa aggaaattac agaagcccat agacacatgc 1560
agaagagacc tcctaagttt agttcttcgt gaagaaagtg ttgttcctag gccctgcaag 1620
gaattatttt ggaaaatgtg caaggtgtgc tacttcttct actcgacgac ggatgggttt 1680
agctcacaag tggagagggc taaagaagtg gatgcggtga tcaatgagcc actaaagcta 1740
caaggaagtc atacgctggt gtctgatgtg tga                              1773

<210> 684
<211> 1665
<212> DNA
<213> Zea mays

<220> 
<223> sesquithujene synthase

<400> 684
atggcgtctc ctccagcaca tcgttccagc aaggcagctg atgaggagct gccaaaggct 60
tcttcgacct tccacccaag cctgtggggc agtttcttcc tgacctacca gccgccaact 120
gcaccccagc gagcaaacat gaaagaacga gctgaggttt taagagaacg tgttaggaag 180
gttttgaagg gctcgacgac tgatcaacta ccagaaacag tgaatcttat attaacattg 240
caaagacttg gactgggtta ctactacgag aacgagatag acaagttgct gcaccaaatt 300
tacagcaact ccgattacaa tgagaaagat cttaacttgg tttcgcagcg gttctacctt 360
cttcgaaaga acggctacga tgtgccatca gatgtatttc tgaacttcaa aacagaagaa 420
ggcggctttg cctgtgctgc tgctgacacg agaagcttgt taagcttata taacgcagca 480
tatctgagga agcatggaga ggaggtacta gacgaagcga tttcatcgac tagactccgc 540
ctccaagatc tccttggacg acttcttcca gaatcgccat ttgcaaagga ggtgtcttct 600
tcccttcgta cccctctctt cagaagggtt gggatactag aagcgagaaa ctacataccc 660
atttacgaaa aggaggcgac gcgaaatgaa gccgtattgg agcttgcgaa actgaatttt 720
aaccttcagc aacttgattt ctgtgaagag ctaaagcatt gctcagcgtg gtggaacgag 780
atgatagcca aatcaaagct gacctttgtt agagatagaa ttgtagagga gtatttctgg 840
atgaatggag catgctgtga tccgccgtac tccctttccc gaattatact gacaaagatc 900
acggggctta ttacaataat cgatgatatg tttgatacac atggtaccac tgaagattgc 960
atgaaattcg ctgaagcatt tggcagatgg gacgaaagtg caatacatct ccttccagag 1020
tacatgaagg atttctacat attgatgttg gagacatttc agtcatttga ggatgcttta 1080
gggccagaga agagctaccg tgtgctttac ctaaaacagg cgatggagcg tttagttgag 1140
ctatactcca aggaaataaa atggcgtgat caggattatg tggcgacaat gagtgaacac 1200
ctccaggttt cagcagagtc catcggagcc aatgctctaa catgttctgc atatgctggg 1260
atgggtgata tgtcgataac aaaggagacc ttcgagtggg ctttgagctt tcctcaattt 1320
ataagaactt ttggttcatt tgtacggctc tccaacgatg tcgtatcgac caagcgtgag 1380
caaacaaaag accatagtcc ctccactgtc cattgttaca tgaaggagca tggaacaacc 1440
atggacgatg catgtgaaaa gataaaggag cttatcgaag attcatggaa ggatatgcta 1500
gagcaatccc ttgcgctgaa agggctccca aaggttgtgc cacagctagt gtttgacttc 1560
tcaagaacca cggataatat gtacagggat cgtgacgcat tgacctcttc ggaagcactc 1620
aaggaaatga tacagctact gtttgtggag ccaatacccg aatga                 1665

<210> 685
<211> 1665
<212> DNA
<213> Zea mays

<220> 
<223> S-beta-bisabolene synthase

<400> 685
atggcgtctc ctccagcaca tcgttccagc aaggcagctg atgaggagct gccaaaggct 60
tcttcgacct ttcacccaag tctgtggggc agtttcttcc tgacctacca gccgccaact 120
gcacctcagc gagcaaacat gaaagaacga gctgaggttt taagagaacg tgttaggaag 180
gttttgaagg gctcgacgac tgatcaacta ccagaaacag tgaatcttat attaacattg 240
caaagacttg gactgggtta ctactacgag aacgagatag acaagttgct gcaccaaatt 300
tacagcaact ccgattacaa tgtgaaagat cttaacttgg tttcgcagcg gttctacctt 360
cttcgaaaga acggctacga tgtgccatca gatgtatttc tgagcttcaa aacagaagaa 420
ggcggcttcg cctgtgctgc tgctgacacg agaagcttgt taagcttata taacgcagca 480
tatctgagga agcatggaga ggaggtacta gacgaagcga tttcatcgac tagactccgc 540
ctccaagatc tccttggacg acttcttcca gaatcgccat ttgcaaagga ggtgtcttct 600
tcccttcgta cccctctctt cagaagggtt gggatactag aagcgagaaa ctacataccc 660
atttacgaaa cggaggcgac gcgaaacgaa gccgtattgg agcttgcgaa actgaatttt 720
aaccttcagc aacttgattt ctgtgaagag ctaaagcatt gctcagcgtg gtggaacgag 780
atgatagcca aatcaaagct gacctttgtt agagatagaa ttgtagagga gtatttctgg 840
atgaatggag catgctatga tccgccgtac tccctttccc gaattatact gacaaagatc 900
acgggactta ttacaataat cgatgatatg tttgatacac atggtaccac tgaagattgc 960
atgaaattcg ctgaagcgtt tggcagatgg gacgaaagtg caatacatct ccttccagag 1020
tacatgaagg atttctacat attgatgttg gagacatttc agtcatttga ggatgcttta 1080
gggccagaga agagctaccg tgtgctttac ctaaaacagg cgatggagcg tttagttgag 1140
ctatactcca aggaaataaa atggcgtgat gatgattatg tgccgacaat gagtgaacac 1200
ctccaggttt cagcagagac catcgcaacc attgctctaa catgttctgc atatgctggg 1260
atgggtgata tgtcgataag aaaggagacc ttcgagtggg ctttgagctt tcctcaattt 1320
ataagaactt ttggttcatt tgtacggctc tccaacgatg tcgtatcgac caagcgtgag 1380
caaacaaaag accatagtcc ctccactgtc cattgttaca tgaaggagca tggaacgacc 1440
atggacgatg catgtgaaaa gataaaggag cttatcgaag attcatggaa ggatatgcta 1500
gagcaatccc ttgcgctgaa agggctccca aaggttgtgc cacagctagt gtttgacttc 1560
tcaagaacca cggataatat gtacagggat cgtgacgcat tgacctcttc ggaagcactc 1620
aaggaaatga tacagctact gtttgtggag ccaatacccg aatga                 1665

<210> 686
<211> 1644
<212> DNA
<213> Zea mays

<220> 
<223> (E)-beta-caryophyllene synthase

<400> 686
atggcagctg atgaggcaag atccgtcagc aggctccaca gtgaggagga catgcatggg 60
aagcaccact ccactctatg gggtgacttc ttccttcacc atgtcccatg tcgtccagga 120
cagtatttga ttatgaagga taacgtcgaa ataatgaagg aggaggtgaa gaaaatgtta 180
ctggatgttg gatcctctga tttgtctcat aagttagact gcattgatac actagaacga 240
cttggattgg attaccacta taccaaggag attgatgaat taatgtgcaa tgtcttcgaa 300
gctagggatc aagatcttga tcttactaca acatcacaac ttttctattt gcttaggaag 360
catggatatc atatttcttc tgatgtattt ttgaagttca gagatgataa aggagatatt 420
gtaacaaatg atgcaaggtg tttactgagg atgtacgaag cggcacatgt tagagtgaac 480
ggtgaagaaa tacttgacaa tattctcatt cacaccaaga gacagcttca atgtattgta 540
gacgatctcg aaccaacact gcaagaagaa gtgagatatg cattggagac acctcttttc 600
agaagactca acagagtaca agccaggcaa ttcatctcaa catacgagaa aagcactacg 660
cgtaacaata tgctcctgga gttctcaaag ttagacttca acatcttgct caccctatat 720
tgtgaggagc taaaagatct tacgctgtgg tggaaagagt tccaagcaca ggctaacacg 780
acaatctatg cacgagatag gatggtggag atgcatttct ggatgatggg agtcttcttt 840
gagccccaat actcctattc acgaaagatg ctcacacagt tgtttatgat cgtgtctgta 900
ctcgatgact tgtatgacag ccattgcacc acagaggaag gcaacgcctt cactgcagca 960
ttacaaaggt gggatgaaga aggcgtggag caatgcccaa catacttgag gactctgtat 1020
acaaatatac gtgccaccgt aaaagccatc gaggaggact tgaatcttca aaacaacaaa 1080
catgcaaagt tggtaaaagg actgataatc gacatggcca tgtgctataa tgccgagaca 1140
gaatggcgtg acaagaaata tgtgccagcc accgttgatg aacatctgaa aatttcagca 1200
cgcagcagtg gctgtatgca cttggtgagc caggggttca tttcgatggg agatgtggca 1260
actagcgagg ccctcgagtg ggcctctacc tatcccaaaa tcgttcgagc tgtctgtatc 1320
attgcacgcc tcgctaacga tataatgtcg tacaagcgag aagcatcaaa caatactatg 1380
gtgtctacag tgcaaacttg tgcaaaggaa tacggcacca ccacagtaga acaggccata 1440
gaaaagatca gagagctgat cgaggaagcg tggatggaca tcacccatga gtgcctcaga 1500
cagccacagc cgatggctct tctcgagagg gcggtcaacc tggctcgtac aatggatttt 1560
ctgtacaaag atgtggatgg atacacagat tcacggagta tcaaaggcat attggattca 1620
ttgtatgtgc atctaataga ctaa                                        1644

<210> 687
<211> 1644
<212> DNA
<213> Zea mays

<220> 
<223> (E)-beta-caryophyllene synthase

<400> 687
atggcagctg atgaggcaag atccgtcagc aggctccaca gtgaggagga catgcatggg 60
aagcaccact ccactctatg gggtgacttc ttccttcacc atgtcccatg tcgtccagga 120
cagtatttga ttatgaagga taacgtcgaa ataatgaagg aggaggtgaa gaaaatgtta 180
ctggatgttg gatcctctga tttgtctcat aagttagact gcattgatac actagaacgg 240
cttggactgg attaccacta taccaaggag attgatgaat taatgtgcaa tgtcttcgaa 300
gctagggatc aagatcttga tcttactaca acatcacagc ttttctattt gcttaggaag 360
catggatatc atatttcttc tgatgtattt ttgaagttca gagatgataa aggagatatc 420
gtaacaaatg atgcaaggtg tttactgagg atgtacgaag cggcacatgt tagagtgaac 480
ggtgaagaaa tacttgacaa tattctcatt cacaccaaga gacaacttca atgtattgta 540
gacgatctcg aaccaacact gcaagaagaa gttagatatg cattggagac acctcttttc 600
agaagactca acagagtaca ggccaggcaa ttcatctcaa catacgagaa aagcactacg 660
cgtaacaata tgctcctgga gttctcaaaa ttagacttca acatcttgct caccctatac 720
tgtgaggagc taaaagatct tacgctgtgg tggaaagagt tccaagcaca ggctaacacg 780
acaatctatg cacgagatag gatggtggag atgcatttct ggatgatggg agtcttcttt 840
gagccccaat actcctattc acgaaagatg ctcacgcagt tgtttatgat cgtgtctgta 900
ctcgatgact tgtatgatag ccattgcacc acagaggaag gcaacgcctt cactgcagca 960
ttacaaaggt gggatgaaga aggcgtggag caatgcccaa catacttgag gactctgtat 1020
acaaatatac gtgccaccat aaaagccatc gaggaggact tgaattttca aaacaacaaa 1080
catgcaaagt tggtaaaagg actgataatc gacatggcca tgtgctataa tgccgagaca 1140
gaatggcgtg acaagaaata tgtgccagcc accgttgatg aacatctgaa aatttcagca 1200
cgcagcagtg gctgtatgca cttggtgagc caggggttca tttcgatggg agatgtggca 1260
actagcgagg ccctcgagtg ggcctctacc tatcccaaaa tcgttcgagc tgtctgtatc 1320
attgcacgcc tcgctaatga tataatgtcg tacaagcgag aagcatcaaa caatactatg 1380
gtgtctacag tgcaaacttg tgcaaaagaa tacggcacca ccacagtaga acaggccata 1440
gaaaagatca gagagctgat cgaggaagcg tggatggaca tcacccatga gtgcctcaga 1500
cagccacagc cgaaggctct tctagagagg gcggtcaacc tggctcgtac aatggatttt 1560
ctgtacaaag atgcggatgg atacacagat tcacggagta tcaaaggcat attggattca 1620
ttgtatgtgc atctaataga ctaa                                        1644

<210> 688
<211> 1644
<212> DNA
<213> Zea perennis

<220> 
<223> (E)-beta-caryophyllene synthase

<400> 688
atggcagctg atgaggcaag atccgtcagc aagctccaca gtgaggagga catgcatggc 60
aagcaccact ccactctatg gggtgacttc ttccttcacc atgtcccatg tcgtccagga 120
cagtatttga ttatgaagga taacgtcgaa ataatgaaag aggaggtgaa gaaaatgtta 180
ctagatgttg gatcctctga tttgtctcat aagttagact gcattgatac actagaacgg 240
cttggattgg gttaccacta taccaaggag attgatgaat taatgtgcaa tgtcttcgaa 300
gctagggatc aagatcttga tcttactaca acatcacaac ttttctattt gcttaggaag 360
catggatatc atatttcttc tgatgtattt ttgaagttca gagatgataa aggagatatc 420
gtaacagatg atgcaaggtg tttactgaga atgtacgaag cggcacatgt tagagtgaac 480
ggtgaagaaa tacttgacaa tattctcagc cacaccaaga gacaacttca atgtattgta 540
gacgacctcg aaccaacact gcaagaagaa gtgagatatg cattggagac acctcttttc 600
agaagactca acagagtaca ggccaggcaa ttcatctcaa catacgagaa aagcactacg 660
cgtaacaata tgctcctgga attctcaaag ttagacttca acatcttgct caccctatac 720
tgtgaggagc taaaagatct tacgctgtgg tggaaagagt tccaagcaca ggctaacaca 780
gcaatctatg cacgagatag gatggtggag atgcatttct ggatgatggg agtcttcttt 840
gagccccaat actcctattc acgaaagatg ctcacacaat tgtttatgat cgtgtctgta 900
ctcgatgact tgtatgacag ccattgcacc acagaggaag gcaacacctt cactgcagca 960
ttacaaaggt gggatgaaga aggcgtggaa caatgcccaa catacttgag gaccttgtat 1020
acaaatatac gtgccaccgt aaaagccatc gaggaggact tgaatcttca aaacaacaaa 1080
catgcaaagt tggtaaaagg actgataatc gacatggcca tgtgctataa tgccgagaca 1140
gaatggcgtg acaagaaata tgtgccagcc accgttgatg aacatctgaa aatttcagca 1200
cgcagcagtg gctgtatgca cttggtgagc caggggttca tttcgatggg agatgtggca 1260
actagcgaga ccctcgagtg ggcctctacc tatcccaaaa tcgttcgagc tgtctgtatc 1320
attgcacgcc tcgctaacga tataatgtcg tacaagcgag aagcatcaaa caatactatg 1380
gtgtctacag tgcaaacttg tgcaaaagaa tacggcacca ccacagtaga acaggccata 1440
gaaaagatca gagagctgat cgaggaagcg tggatggacg tcacccatga gtgcctcaga 1500
cagccacagc cgaaggctct tctagagagg gcggtcaacc tggctcgtac aatggatttt 1560
ctgtacaaag atgtggatgg atacacagat tcacggagta tcaaaggcat attggattca 1620
ttgtatgtgc atctaataga ctaa                                        1644

<210> 689
<211> 1653
<212> DNA
<213> Zingiber officinale

<220> 
<223> germacrene D synthase

<400> 689
atggagaacc aatctctaac ttttgttggt gatgaagaag caaaggttcg taagtcaaca 60
aaatttcatc caagcatttg gggtgattat tttatccaaa actcctcgct ctctcacgca 120
gaggagtcca ctcaaaggat gataaagagg gtggaagaat taaaggtgca agtaaagagc 180
atgttcaagg acactagtga catattgcaa cttatgaatt tgattgattc aattcaaatg 240
cttggattgg actaccattt tgagaatgaa atagataaag cactaagatt gatcaatgaa 300
gttgatgata agagctatgg actttatgaa acttctttaa gatttcgatt gcttaggcaa 360
catggaaatc atgtatctac agatattttt aacaagttca aaggtgacaa tggaagcttt 420
atatcttcct tgaatggaga tgccaaggga ttattaagct tatataatgc gtcttatctt 480
ggaacacatg gagagactat acttgatgaa gccaagtctt ttgcaaagcc tcagcttata 540
tccttattga gtgaacttga acaatcttta gccgcgcagg tcacactttt ccttgagtta 600
ccacttcata aaagagtcaa aattctcttg gtgagaaaat atatacttat ttatcaagag 660
ggtgcaatgc gaaacaatgt cctattagaa tttgcaaagt tgaatttcaa tttactacaa 720
tctctttatc aagaagaact gaagaaaatt tcaatatggt ggtatgattt agcacttgct 780
aaatcactaa gttttactcg tgaccgaatt gtggaatgct attattgggt tcttacttta 840
tattttgatc ctcaatattc tcattcccga ttgatttact ccaaagtgat ttctcttgta 900
tcaattatgg atgatatcta tgataactat ggcacattgg aagagtgcag acaattaact 960
gaagcaatca aaaggtggaa acctcaagct attgatagtt taccggaata tttgaaatat 1020
ttctatctca agctattaaa gacttttgaa gaaattggag aagagttgga acataatgag 1080
aaatatcgta tgctatatct tcaagatcaa ataaaggcta tagcggtagc ttatcttgaa 1140
gaagctaagt ggagtattga gcgacatgtg ccatcacttg atgaacactt gcattattcg 1200
ttaattacct ctgggtgttc tttagtccct tgtgcctctt acgtaggtat gggagaagtg 1260
gcaacaaaag aggtattcga ctggcattct agttttccca aggccgtaga agcttgttgt 1320
gcaattggaa gaatcttgaa tgatataaca tcatatgagc gggagcaagg gagaggcgat 1380
aatgcctcta cagtggaaag ttacatgaaa gatcatggta caaatgaaaa agacgcatgt 1440
aagaagctgc aagagatagt agagaaagca tggaaggatc tgaaccaaga gtctcttaat 1500
caaaaaaata tatctcgact tataattgaa agactggtca acttttcaag atcaatggaa 1560
gaaatataca tgtctaatga tatgtacacc aattccggca ctaagatgaa aggtaatatc 1620
actttagtgt tggttgaagc ttttcctgta taa                              1653

<210> 690
<211> 1647
<212> DNA
<213> Zingiber zerumbet

<220> 
<223> alpha-humulene synthase

<400> 690
atggagaggc agtcgatggc ccttgttggt gataaggaag agataattcg taagtcattt 60
gaatatcacc ctactgtttg gggtgactat ttcatccgga actactcttg tttgcccctc 120
gaaaaggagt gcatgataaa gagggtggaa gagttaaaag atcgagtgag aaacctattc 180
gaggaaacac atgacgtatt gcaaattatg attttggttg attcgattca acttcttgga 240
ttggattatc attttgagaa agaaataact gcggcactaa gattgattta cgaggctgat 300
gttgagaatt atgggcttta tgaagtttcc cttcgattta gattgcttag gcaacatgga 360
tataatttgt ctccagatgt tttcaacaag ttcaaagatg ataagggcag atttttgccg 420
accttgaatg gagatgcaaa gggactacta aacttataca atgcggctta tcttggaaca 480
catgaagaga ctatactcga cgaagctatt tcttttacaa agtgccaact tgaatctttg 540
ttgggtgaac ttgagcagcc tttagcaata gaggtgtctc ttttccttga aacaccacta 600
tatcgaagaa ctagaagact cttggtgaga aaatatatac ctatttatca agagaaagtg 660
atgcgaaatg atactatatt agaacttgca aagttggatt tcaatctact acaatctctc 720
catcaagagg aagtgaagaa aattacaata tggtggaatg atttagcact gactaaatct 780
ttaaaatttg ctcgtgaccg agtagtggaa tgttattatt ggatagttgc ggtgtatttt 840
gaacctcaat attctcgagc acgagtaatt acttccaagg ccatttctct tatgtcgatt 900
atggatgaca tctatgataa ctacagcaca ttagaagaaa gtcgactatt aactgaggca 960
atcgaaaggt gggaacccca agcagttgat tgtgtaccag aatacttaaa agacttttat 1020
ctcaagctat taaagactta caaagatttc gaagatgaac tagaacccaa tgaaaagtat 1080
cgcataccat atcttcaaga ggaaataaaa gttctatcaa gagcttattt ccaagaagct 1140
aaatggggtg tggaaagata tgtaccagca ctcgaggagc atcttcttgt ttcattgata 1200
acagccgggt attttgcggt tgcatgtgcc tcttacgtag gtttgggaga agatgcaaca 1260
aaagagacat ttgaatgggt tgctagttcc cctaagatcc ttaaatcctg cagtatacat 1320
tgtagactta tggatgatat aacttcacac cagcgggaac aagaaagaga ccatttcgct 1380
tcaacagttg agagttacat gaaagagcat ggtacaagtg caaaagtggc ttgcgagaag 1440
ttgcaagtga tggtggagca aaaatggaag gatttgaacg aggaatgcct acgtccaaca 1500
caagtagctc ggcctttaat tgaaataata ttgaacctct caagagccat ggaagacata 1560
tacaagcaca aagatactta tactaattcc aacactagga tgaaagacaa tgtctctctc 1620
atatttgttg aatcctttct tatttaa                                     1647

<210> 691
<211> 1665
<212> DNA
<213> Zingiber zerumbet

<220> 
<223> beta-eudesmol synthase

<400> 691
atggagaagc aatcactaac ttttgatggt gatgaagaag caaaaatcga tcgtaagtca 60
tcaaaatatc atccaagcat ttggggtgat tattttatcc aaaattcctc gctcactcat 120
gcaaaggagt ccactcaaag gatgataaag agagtggaag aattaaaggt gcaagtaaag 180
agcatgttca aggacactag tgacttattg caacttatga atttgattaa ttcaattcaa 240
atgcttggat tggactacca tttcgagaat gaaatagatg aagcactaag attgatttat 300
gaagttgatg ataaaagcta tgggctttat gaaacttctc taagatttca attgcttagg 360
caacatggat atcatgtatc tgcagatatt tttaacaagt tcaaagatga caatggaagc 420
tttatatctt ccttgaatgg agatgccaag ggattattaa gcttatataa tgtgtcttat 480
cttggaacac atggagagac tatacttgat gaagccaagt cttttacaaa gccacagctt 540
gtatcattaa tgagtgaact tgaacaatct ttagccgcgc aggtctctct tttccttgag 600
ttaccactat gtcgaagaaa taaaattctc ttggcgcgaa aatatatact tatttatcaa 660
gaagatgcaa tgcgaaacaa tgtcatatta gaacttgcaa agttgaattt caatttacta 720
caatctcttt atcaagagga attgaagaaa atttcaatat ggtggaatga tttagcattt 780
gctaagtctc taagttttac tcgtgaccga gttgtggaag gttattattg ggttcttact 840
atatattttg agcctcagca ttctcgtgca cgagtgattt gctccaaagt atttgctttt 900
ctatcaatta tggatgatat ttatgataac tatggcatat tggaagagtg tacactatta 960
actgaagcaa tcaaaaggtg gaatcctcaa gctattgacg gtttaccaga atacttgaaa 1020
gattactatc tcaagctatt aaagactttc gaagaatttg aagatgagtt ggaacttaat 1080
gagaagtatc gtatgctata tcttcaagat gaagtaaagg ctctagcaat atcttatctt 1140
caagaagcta agtggggtat cgagcgacat gtgccatcac ttgacgaaca cttgcataat 1200
tcattaatct ccagtgggag ttctacagtc atttgtgcct cttttgtagg tatgggggaa 1260
gtggcaacaa aagaggtgtt cgactggctt tctagttttc ccaaggttgt agaagcttgt 1320
tgtgtaattg gtagactctt gaatgatata agatcacatg agctggagca agggagagat 1380
cacactgcct ctacagtgga aagttacatg aaagagcatg acacaaatgt agatgttgca 1440
tgcgagaagc tgcgagagat agtagagaaa gcgtggaagg atctaaacaa cgagtcactt 1500
aatccaacaa aagtacctcg acttatgatt gaaagaatag tcaacctttc aaaatcaaat 1560
gaagaaatat acaagtataa cgatacgtac accaattctg acactacgat gaaagataat 1620
atctctttgg tgttagttga atcttgtgac tacttcaata agtaa                 1665

<210> 692
<211> 5181
<212> DNA
<213> Artificial Sequence

<220> 
<223> YEP352-URA plasmid

<400> 692
atgaccatga ttacgaattc gagctcggta cccggggatc ctctagagtc gacctgcagg 60
catgcaagct tggcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt 120
acccaactta atcgccttgc agcacatccc cccttcgcca gctggcgtaa tagcgaagag 180
gcccgcaccg atcgcccttc ccaacagttg cgcagcctga atggcgaatg gcgcctgatg 240
cggtattttc tccttacgca tctgtgcggt atttcacacc gcatagggta ataactgata 300
taattaaatt gaagctctaa tttgtgagtt tagtatacat gcatttactt ataatacagt 360
tttttagttt tgctggccgc atcttctcaa atatgcttcc cagcctgctt ttctgtaacg 420
ttcaccctct accttagcat cccttccctt tgcaaatagt cctcttccaa caataataat 480
gtcagatcct gtagagacca catcatccac ggttctatac tgttgaccca atgcgtctcc 540
cttgtcatct aaacccacac cgggtgtcat aatcaaccaa tcgtaacctt catctcttcc 600
acccatgtct ctttgagcaa taaagccgat aacaaaatct ttgtcgctct tcgcaatgtc 660
aacagtaccc ttagtatatt ctccagtaga tagggagccc ttgcatgaca attctgctaa 720
catcaaaagg cctctaggtt cctttgttac ttcttctgcc gcctgcttca aaccgctaac 780
aatacctggg cccaccacac cgtgtgcatt cgtaatgtct gcccattctg ctattctgta 840
tacacccgca gagtactgca atttgactgt attaccaatg tcagcaaatt ttctgtcttc 900
gaagagtaaa aaattgtact tggcggataa tgcctttagc ggcttaactg tgccctccat 960
ggaaaaatca gtcaagatat ccacatgtgt ttttagtaaa caaattttgg gacctaatgc 1020
ttcaactaac tccagtaatt ccttggtggt acgaacatcc aatgaagcac acaagtttgt 1080
ttgcttttcg tgcatgatat taaatagctt ggcagcaaca ggactaggat gagtagcagc 1140
acgttcctta tatgtagctt tcgacatgat ttatcttcgt ttcggttttt gttctgtgca 1200
gttgggttaa gaatactggg caatttcatg tttcttcaac actacatatg cgtatatata 1260
ccaatctaag tctgtgctcc ttccttcgtt cttccttctg ttcggagatt accgaatcaa 1320
aaaaatttca aagaaaccga aatcaaaaaa aagaataaaa aaaaaatgat gaattgaaaa 1380
gctcttgtta cccatcattg aattttgaac atccgaacct gggagttttc cctgaaacag 1440
atagtatatt tgaacctgta taataatata tagtctagcg ctttacggaa gacaatgtat 1500
gtatttcggt tcctggagaa actattgcat ctattgcata ggtaatcttg cacgtcgcat 1560
ccccggttca ttttctgcgt ttccatcttg cacttcaata gcatatcttt gttaacgaag 1620
catctgtgct tcattttgta gaacaaaaat gcaacgcgag agcgctaatt tttcaaacaa 1680
agaatctgag ctgcattttt acagaacaga aatgcaacgc gaaagcgcta ttttaccaac 1740
gaagaatctg tgcttcattt ttgtaaaaca aaaatgcaac gcgagagcgc taatttttca 1800
aacaaagaat ctgagctgca tttttacaga acagaaatgc aacgcgagag cgctatttta 1860
ccaacaaaga atctatactt cttttttgtt ctacaaaaat gcatcccgag agcgctattt 1920
ttctaacaaa gcatcttaga ttactttttt tctcctttgt gcgctctata atgcagtctc 1980
ttgataactt tttgcactgt aggtccgtta aggttagaag aaggctactt tggtgtctat 2040
tttctcttcc ataaaaaaag cctgactcca cttcccgcgt ttactgatta ctagcgaagc 2100
tgcgggtgca ttttttcaag ataaaggcat ccccgattat attctatacc gatgtggatt 2160
gcgcatactt tgtgaacaga aagtgatagc gttgatgatt cttcattggt cagaaaatta 2220
tgaacggttt cttctatttt gtctctatat actacgtata ggaaatgttt acattttcgt 2280
attgttttcg attcactcta tgaatagttc ttactacaat ttttttgtct aaagagtaat 2340
actagagata aacataaaaa atgtagaggt cgagtttaga tgcaagttca aggagcgaaa 2400
ggtggatggg taggttatat agggatatag cacagagata tatagcaaag agatactttt 2460
gagcaatgtt tgtggaagcg gtattcgcaa tattttagta gctcgttaca gtccggtgcg 2520
tttttggttt tttgaaagtg cgtcttcaga gcgcttttgg ttttcaaaag cgctctgaag 2580
ttcctatact ttctagctag agaataggaa cttcggaata ggaacttcaa agcgtttccg 2640
aaaacgagcg cttccgaaaa tgcaacgcga gctgcgcaca tacagctcac tgttcacgtc 2700
gcacctatat ctgcgtgttg cctgtatata tatatacatg agaagaacgg catagtgcgt 2760
gtttatgctt aaatgcgtta tggtgcactc tcagtacaat ctgctctgat gccgcatagt 2820
taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc 2880
cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt 2940
caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg 3000
ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc 3060
gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac 3120
aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt 3180
tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag 3240
aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg 3300
aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa 3360
tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc 3420
aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag 3480
tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa 3540
ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc 3600
taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg 3660
agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa 3720
caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa 3780
tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg 3840
gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag 3900
cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg 3960
caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt 4020
ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt 4080
aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac 4140
gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag 4200
atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg 4260
tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca 4320
gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga 4380
actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca 4440
gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc 4500
agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca 4560
ccgaactgag atacctacag cgtgagcatt gagaaagcgc cacgcttccc gaagggagaa 4620
aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc 4680
cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc 4740
gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg 4800
cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat 4860
cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca 4920
gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca 4980
aaccgcctct ccccgcgcgt tggccgattc attaatccag ctggcacgac aggtttcccg 5040
actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag ttacctcact cattaggcac 5100
cccaggcttt acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac 5160
aatttcacac aggaaacagc t                                           5181



<210> 693
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V182

<400> 693
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattaa actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg cccgaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 694
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V183

<400> 694
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcag tgaagctggg 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 695
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant 194

<400> 695
atgcagagca ttacggacaa gagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 696
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V196

<400> 696
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctgccca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcctt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 697
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V197

<400> 697
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttcttcgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 698
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V198

<400> 698
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctaagca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 699
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V200

<400> 699
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttataatg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt gatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca cggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 700
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V202

<400> 700
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgccttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 701
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V208

<220> 
<221> variation      
<222> 1334, 1336
<223> n = a or c or t or g

<400> 701
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattctcc ctcgcttctc gcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggncnatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 702
<211> 1641
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V232, V233, V234 and V235

<400> 702
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt taccactact catttgcaat ctgcagctcc acatttgaag 540
tcacctttgg ctgaacaaat taaccatgct ttgtatagac cattgagaaa aactttgcca 600
agattggaag caagatacat tatgtcaaga attgattcta cttctgatga tttggttaac 660
aagactttgt taaatttcgc taagttggat ttcaatattt tgttggattt gcataaagaa 720
gaattgaacg aattgactaa atggtggcaa gatttggatt ttactactaa attgccatat 780
gctagagata gattggttga attgtacttt tgggatttgg ggacttattt tgaatcacaa 840
tacgcttttg gtagaaaaat catgactaaa ttgaactaca ttttgtccat tattgatgat 900
acctacgatg cttacggtac tttggaagaa tgcacgatgt tcagtgaagc tgttgctcgt 960
tggaacattg aagctgttga tatgttgcca gattatatgc gaattatcta cagaactttg 1020
ttggatacat tcaacgaaat agaagaggat atggctaaac aacggagatc tcattgtgta 1080
agatacgcta aagaagaaat tcaaaaggtt attggtgctt attacgttca agctaagtgg 1140
ttttctgaag gttatgtccc tactattgaa gaatacatgc caattgcttt gacttcttgc 1200
gcttacagat ttgttattac caattctttt ttgggtatgg gtgatttcgc tacaaaggaa 1260
gtattcgaat ggatttctgg taatccaaaa gttgttaaat ctgcttctgt tatttgtaga 1320
ttgatggacg atatgcaagg acacgaattt gaacaaaaaa gaggtcacgt tgcatctgca 1380
attgaatgct atactaaaca acatggtgtt tccaaggaag aggctatcaa gatgttcgag 1440
gaagaggttg ctaacgcttg gaaggatatc aatgaagaat taatgatgaa accaccagtt 1500
gttgctagac cattgttagg tactattttg aatttggcta gagctatcga ttttatctat 1560
aaagaagatg acggttacac tcattcttat ttgattaagg aacaaatagc atctgttttg 1620
ggtgatcatg ttccatttta a                                           1641

<210> 703
<211> 1641
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V237 and V238

<400> 703
atgcgggaca agggtacgtg tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat ctgcagctcc acatttgaag 540
tcacctttgg ctgaacaaat taaccatgct ttgtatagac cattgagaaa aactttgcca 600
agattggaag caagatacat tatgtcaaga attgattcta cttctgatga tttggttaac 660
aagactttgt taaatttcgc taagttggat ttcaatattt tgttggattt gcataaagaa 720
gaattgaacg aattgactaa atggtggcaa gatttggatt ttactactaa attgccatat 780
gctagagata gattggttga attgtacttt tgggatttgg ggacttattt tgaatcacaa 840
tacgcttttg gtagaaaaat catgactaaa ttgaactaca ttttgtccat tattgatgat 900
acctacgatg cttacggtac tttggaagaa tgcacgatgt tcagtgaagc tgttgctcgt 960
tggaacattg aagctgttga tatgttgcca gattatatgc gaattatcta cagaactttg 1020
ttggatacat tcaacgaaat agaagaggat atggctaaac aacggagatc tcattgtgta 1080
agatacgcta aagaagaaat tcaaaaggtt attggtgctt attacgttca agctaagtgg 1140
ttttctgaag gttatgtccc tactattgaa gaatacatgc caattgcttt gacttcttgc 1200
gcttacagat ttgttattac caattctttt ttgggtatgg gtgatttcgc tacaaaggaa 1260
gtattcgaat ggatttctgg taatccaaaa gttgttaaat ctgcttctgt tatttgtaga 1320
ttgatggacg atatgcaagg acacgaattt gaacaaaaaa gaggtcacgt tgcatctgca 1380
attgaatgct atactaaaca acatggtgtt tccaaggaag aggctatcaa gatgttcgag 1440
gaagatgttg ctaacgcttg gaaggatatc aatgaagaat taatgatgaa accaccagtt 1500
gttgctagac cattgttagg tactattttg aatttggcta gagctatcga ttttatctat 1560
aaagaagatg acggttacac tcattcttat ttgattaagg aacaaatagc atctgttttg 1620
ggtgatcatg ttccatttta a                                           1641

<210> 704
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V209

<400> 704
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattacgg ccgttgccca gcccccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttcca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 705
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V210

<400> 705
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt taaaggaaga agttagaaga atgattcgag cacaaaccgc ccggccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaatccata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttacttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 706
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V211

<400> 706
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattcggt gcgttcagcc agagccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcca gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 707
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V212

<400> 707
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtggattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 708
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V213

<400> 708
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacaaatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaggctgtt 960
gctcgttgga acattgaggc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact atcgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 709
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V214

<400> 709
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatgggg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 710
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V215

<400> 710
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ctttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccagt tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 711
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V216

<400> 711
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaatcaac catgctttgt atagaccatt gagaaaaact 600
ttgccaaggt tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 712
<211> 1635
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V217 (encoding AA5-548)

<400> 712
gaaactttta gaccaactgc tgattttcat ccatctttgt ggagaaatca ttttttgcaa 60
ggtgcatcag attttaagac tgttgatcat acagctacaa atgaaagaca tgaagctttg 120
aaggaagaag ttagaagaat gattactgat gcagaagatc aaccaattca aaaattgaga 180
ttgattgatg aagttcaaag attgggtgtt gcttaccatt ttgaaaaaga aattgaagat 240
gctattcaac aattgtgtcc aattcatatt gattctgata aagctgattt gcatactgtt 300
tctttgcatt tcagattgtt gagacaacaa ggtattaaga tttcttgtga tgttttcgaa 360
caatttaagg atgatgaagg tagattcaaa agttctttga ttaatgatgt tcaaggcatg 420
ttgtctttgt atgaagctgc ttatatggct gttagaggtg aacatatttt ggatgaagct 480
attgcattta ctactactca tttgcaatca ttggttgcac aagatcatgt tactccaaga 540
ttggctgaac aagcgaacca tgctttgtat agaccattga gaaaaacttt gccaagattg 600
gaagcaagat acattatgtc aagaattgat tctacttctg atgatttggt taacaagact 660
ttgttaaatt tcgctaagtt ggatttcaat attttgttgg atttgcataa agaagaattg 720
aacgaattga ctaaatggtg gcaagatttg gattttacta ctaaattgcc atatgctaga 780
gatagattgg ttgaattgta cttttgggat ttgggtactt attttgaacc acaatacgct 840
tttggtagaa aaatcatgac taaattgaac tacattttgt ccattattga tgatacctac 900
gatgcttacg gtactttgga agaattgtct ttgttcaccg aagctgttgc tcgttggaac 960
attgaagctg ttgacatgtt gccagattat atgaagttaa tctacagaac tttgttggat 1020
acattcaacg aaatagaaga ggatatggct aaacaaggta gatctcattg tgtaagatac 1080
gctaaagaag aaattcaaaa ggttattggt gcttattacg ttcaagctaa gtggttttct 1140
gaaggttatg tccctactat tgaagaatac atgccaattg ctttgacttc ttgcgcttac 1200
agatttgtta ttaccaattc ttttttgggt atgggtgatt tcgctacaaa ggaagtattc 1260
gaatggattt ctggtaatcc aaaagttgtt aaatctgctt ctgttatttg tagattgatg 1320
gacgatatgc aaggacacga atttgaacaa aaaagaggtc acgttgcatc tgcaattgaa 1380
tgctatacta aacaacatgg tgtttccaag gaagaggcta tcaagatgtt cgaggaagag 1440
gttgctaacg cttggaagga tatcaatgaa gaattaatga tgaaaccacc agttgttgct 1500
agaccattgt taggtactat tttgaatttg gctagagcta tcgattttat ctataaagaa 1560
gatgacggtt acactcattc ttatttgatt aaggaacaaa tagcatctgt tttgggtgat 1620
catgttccat tttaa                                                  1635

<210> 713
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V239

<400> 713
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt cgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 714
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V240

<400> 714
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 715
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V241

<400> 715
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaagattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggagg tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 716
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V218 and V219

<400> 716
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactcac cccgaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 717
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V185

<400> 717
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcac aaggttattg gtgactatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattggcaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aaggattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 718
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V220

<400> 718
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctctgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaaattatc tgaggcgtat tcccgcagat 660
tctaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 719
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V221

<400> 719
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacgac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcagactatg agcaccaatc tattttagtt 660
caaaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 720
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V224

<400> 720
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaggctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaaatatgt cttcgtaccg ggggtgcagc 660
gtgaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaaactgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 721
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V225

<400> 721
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcagatgcaa acggtgaaaa ggtcttgagt 660
tttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 722
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V226

<400> 722
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcatcacgtt ccaagccgtt ttgctggacc 660
tccaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcctgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 723
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V182

<400> 723
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Pro Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 724
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V183

<400> 724
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Ser Glu Ala Gly
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 725
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V194

<400> 725
Met Gln Ser Ile Thr Asp Lys Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 726
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V196

<400> 726
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Ala His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 727
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V197

<400> 727
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Ser His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 728
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V198

<400> 728
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Lys His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 729
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V200

<400> 729
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Asn Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Thr Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 730
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V202

<400> 730
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Ala Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 731
<211> 546
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V208

<400> 731
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Pro Arg Phe Ser Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Met Gln Gly His
        435                 440                 445             
Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr
    450                 455                 460                 
Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe Glu
465                 470                 475                 480 
Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met Met
                485                 490                 495     
Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu
            500                 505                 510         
Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His
        515                 520                 525             
Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His Val
    530                 535                 540                 
Pro Phe
545     


<210> 732
<211> 546
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V232, V233, V234, V235 and V236

<400> 732
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Ala Ala
                165                 170                 175     
Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His Ala Leu Tyr
            180                 185                 190         
Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr Ile Met
        195                 200                 205             
Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr Leu Leu
    210                 215                 220                 
Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His Lys Glu
225                 230                 235                 240 
Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr Thr
                245                 250                 255     
Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp Asp
            260                 265                 270         
Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys Ile Met
        275                 280                 285             
Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp Ala
    290                 295                 300                 
Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val Ala Arg
305                 310                 315                 320 
Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg Ile Ile
                325                 330                 335     
Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp Met Ala
            340                 345                 350         
Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu Ile Gln
        355                 360                 365             
Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu Gly
    370                 375                 380                 
Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser Cys
385                 390                 395                 400 
Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly Asp Phe
                405                 410                 415     
Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys Val Val
            420                 425                 430         
Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln Gly His
        435                 440                 445             
Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr
    450                 455                 460                 
Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe Glu
465                 470                 475                 480 
Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met Met
                485                 490                 495     
Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu
            500                 505                 510         
Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His
        515                 520                 525             
Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His Val
    530                 535                 540                 
Pro Phe
545     


<210> 733
<211> 546
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V237 and V238

<400> 733
Met Arg Asp Lys Gly Thr Cys Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Ala Ala
                165                 170                 175     
Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His Ala Leu Tyr
            180                 185                 190         
Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr Ile Met
        195                 200                 205             
Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr Leu Leu
    210                 215                 220                 
Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His Lys Glu
225                 230                 235                 240 
Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr Thr
                245                 250                 255     
Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp Asp
            260                 265                 270         
Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys Ile Met
        275                 280                 285             
Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp Ala
    290                 295                 300                 
Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val Ala Arg
305                 310                 315                 320 
Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg Ile Ile
                325                 330                 335     
Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp Met Ala
            340                 345                 350         
Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu Ile Gln
        355                 360                 365             
Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu Gly
    370                 375                 380                 
Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser Cys
385                 390                 395                 400 
Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly Asp Phe
                405                 410                 415     
Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys Val Val
            420                 425                 430         
Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln Gly His
        435                 440                 445             
Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr
    450                 455                 460                 
Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe Glu
465                 470                 475                 480 
Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met Met
                485                 490                 495     
Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu
            500                 505                 510         
Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His
        515                 520                 525             
Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His Val
    530                 535                 540                 
Pro Phe
545     


<210> 734
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V209

<400> 734
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Ala Val Ala Gln Pro Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Phe His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 735
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V210

<400> 735
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Arg Ala Gln Thr Ala Arg Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 736
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V211

<400> 736
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Arg Cys Val Gln Pro Glu Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 737
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V212

<400> 737
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Gly Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 738
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V213

<400> 738
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu Gln Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 739
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V214

<400> 739
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Gly Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 740
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V215

<400> 740
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Val Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 741
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V216

<400> 741
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 742
<211> 544
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V217 (AA5-548)

<400> 742
Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser Leu Trp Arg Asn
 1               5                  10                  15      
His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val Asp His Thr Ala
            20                  25                  30          
Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val Arg Arg Met Ile
        35                  40                  45              
Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg Leu Ile Asp Glu
    50                  55                  60                  
Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys Glu Ile Glu Asp
65                  70                  75                  80  
Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser Asp Lys Ala Asp
                85                  90                  95      
Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg Gln Gln Gly Ile
            100                 105                 110         
Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp Asp Glu Gly Arg
        115                 120                 125             
Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met Leu Ser Leu Tyr
    130                 135                 140                 
Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile Leu Asp Glu Ala
145                 150                 155                 160 
Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val Ala Gln Asp His
                165                 170                 175     
Val Thr Pro Arg Leu Ala Glu Gln Ala Asn His Ala Leu Tyr Arg Pro
            180                 185                 190         
Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr Ile Met Ser Arg
        195                 200                 205             
Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr Leu Leu Asn Phe
    210                 215                 220                 
Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His Lys Glu Glu Leu
225                 230                 235                 240 
Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr Thr Lys Leu
                245                 250                 255     
Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp Asp Leu Gly
            260                 265                 270         
Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys Ile Met Thr Lys
        275                 280                 285             
Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp Ala Tyr Gly
    290                 295                 300                 
Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val Ala Arg Trp Asn
305                 310                 315                 320 
Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys Leu Ile Tyr Arg
                325                 330                 335     
Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp Met Ala Lys Gln
            340                 345                 350         
Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu Ile Gln Lys Val
        355                 360                 365             
Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu Gly Tyr Val
    370                 375                 380                 
Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser Cys Ala Tyr
385                 390                 395                 400 
Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly Asp Phe Ala Thr
                405                 410                 415     
Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys Val Val Lys Ser
            420                 425                 430         
Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln Gly His Glu Phe
        435                 440                 445             
Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr Thr Lys
    450                 455                 460                 
Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe Glu Glu Glu
465                 470                 475                 480 
Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met Met Lys Pro
                485                 490                 495     
Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu Ala Arg
            500                 505                 510         
Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His Ser Tyr
        515                 520                 525             
Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His Val Pro Phe
    530                 535                 540                 


<210> 743
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V239

<400> 743
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Ser Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 744
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V240

<400> 744
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 745
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V242

<220> 
<221> VARIANT        
<222> 62
<223> Xaa = Lys or Arg

<400> 745
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Xaa Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 746
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V218 and V219

<400> 746
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr His Pro Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 747
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V220

<400> 747
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Asn Tyr Leu Arg Arg Ile Pro Ala Asp Ser Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 748
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V221

<400> 748
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Arg Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Asp Tyr Glu His Gln Ser Ile Leu Val Gln Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 749
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V224

<400> 749
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Asn Met Ser Ser Tyr Arg Gly Cys Ser Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Thr Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 750
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V225

<400> 750
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Asp Ala Asn Gly Glu Lys Val Leu Ser Phe Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 751
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V226

<400> 751
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Ser Arg Ser Lys Pro Phe Cys Trp Thr Ser Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 752
<211> 548
<212> PRT
<213> Citrus paradisi

<220> 
<223> Citrus valencene synthase

<400> 752
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Lys Leu Cys Pro Asn Tyr Ile His Ser
                85                  90                  95      
Asn Ser Pro Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Tyr Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 753
<211> 1647
<212> DNA
<213> Citrus paradisi

<220> 
<223> Citrus valencene synthase

<400> 753
atgtcgtctg gagaaacatt tcgtcctact gcagatttcc atcctagttt atggagaaac 60
catttcctca aaggtgcttc tgatttcaag acagttgatc atactgcaac tcaagaacga 120
cacgaggcac tgaaagaaga ggtaaggaga atgataacag atgctgaaga taagcctgtt 180
cagaagttac gcttgattga tgaagtacaa cgcctggggg tggcttatca ctttgagaaa 240
gaaatagaag atgcaataca aaaattatgt ccaaactata ttcacagtaa tagccctgat 300
cttcacaccg tttctcttca ttttcgattg cttaggcagc aaggaatcaa gatttcatgt 360
gatgtgtttg agaagttcaa agatgatgag ggtagattca agtcatcgtt gataaacgat 420
gttcaaggga tgttaagttt gtacgaggca gcatacatgg cagttcgcgg agaacatata 480
ttagatgaag ccattgcttt cactaccact cacctgaagt cattggtagc tcaggatcat 540
gtaaccccta agcttgcgga acagataaat catgctttat accgtcctct tcgtaaaacc 600
ctaccaagat tagaggcgag gtattttatg tccatgatca attcaacaag tgatcattta 660
tacaataaaa ctctgctgaa ttttgcaaag ttagatttta acatattgct agagctgcac 720
aaggaggaac tcaatgaatt aacaaagtgg tggaaagatt tagacttcac tacaaaacta 780
ccttatgcaa gagacagatt agtggagtta tatttttggg atttagggac atacttcgag 840
cctcaatatg catttgggag aaagataatg acccaattaa attacatatt atccatcata 900
gatgatactt atgatgcgta tggtacactt gaagaactca gcctctttac tgaagcagtt 960
caaagatgga atattgaggc cgtagatatg cttccagaat acatgaaatt gatttacagg 1020
acactcttag atgcttttaa tgaaattgag gaagatatgg ccaagcaagg aagatcacac 1080
tgcgtacgtt atgcaaaaga ggagaatcaa aaagtaattg gagcatactc tgttcaagcc 1140
aaatggttca gtgaaggtta cgttccaaca attgaggagt atatgcctat tgcactaaca 1200
agttgtgctt acacattcgt cataacaaat tccttccttg gcatgggtga ttttgcaact 1260
aaagaggttt ttgaatggat ctccaataac cctaaggttg taaaagcagc atcagttatc 1320
tgcagactca tggatgacat gcaaggtcat gagtttgagc agaagagagg acatgttgcg 1380
tcagctattg aatgttacac gaagcagcat ggtgtctcta aggaagaggc aattaaaatg 1440
tttgaagaag aagttgcaaa tgcatggaaa gatattaacg aggagttgat gatgaagcca 1500
accgtcgttg cccgaccact gctcgggacg attcttaatc ttgctcgtgc aattgatttt 1560
atttacaaag aggacgacgg ctatacgcat tcttacctaa ttaaagatca aattgcttct 1620
gtgctaggag accacgttcc attttga                                     1647

<210> 754
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V179

<400> 754
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcatcttacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg cctgaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 755
<211> 1350
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V180 (encoding AA 100-548)

<400> 755
gatttgcata ctgtttcttt gcatttcaga ttgttgagac aacaaggtat taagatttct 60
tgtgatgttt tcgaacaatt taaggatgat gaaggtagat tcaaaagttc tttgattaat 120
gatgttcaag gcatgttgtc tttgtatgaa gctgcttata tggctgttag aggtgaacat 180
attttggatg aagctattgc atttactact actcatttgc aatcattggt tgcacaagat 240
catgttactc caagattggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 300
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 360
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 420
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 480
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 540
gaatcatctt acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 600
attgatgata cctacgatgc ttacggtact cacgaagaat tgtctttgtt caccaaagct 660
gttgctcgtt ggaacattga agctgttgac atgttgccag attatatgaa gttaatctac 720
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca aggtagatct 780
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 840
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 900
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 960
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1020
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1080
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1140
atgttcgagg aagaggttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1200
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1260
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1320
tctgttttgg gtgatcatgt tccattttaa                                  1350

<210> 756
<211> 1485
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V181 (encoding AA 55-548)

<400> 756
gcagaagatc aaccaattca aaaattgaga ttgattgatg aagttcaaag attgggtgtt 60
gcttaccatt ttgaaaaaga aattgaagat gctattcaac aattgtgtcc aattcatatt 120
gattctgata aagctgattt gcatactgtt tctttgcatt tcagattgtt gagacaacaa 180
ggtattaaga tttcttgtga tgttttcgaa caatttaagg atgatgaagg tagattcaaa 240
agttctttga ttaatgatgt tcaaggcatg ttgtctttgt atgaagctgc ttatatggct 300
gttagaggtg aacatatttt ggatgaagct attgcattta ctactactca tttgcaatca 360
ttggttgcac aagatcatgt tactccaaga ttggctgaac aaattaacca tgctttgtat 420
agaccattga gaaaaacttt gccaagattg gaagcaagat acattatgtc aagaattgat 480
tctacttctg atgatttggt taacaagact ttgttaaatt tcgctaagtt ggatttcaat 540
attttgttgg atttgcataa agaagaattg aacgaattga ctaaatggtg gcaagatttg 600
gattttacta ctaaattgcc atatgctaga gatagattgg ttgaattgta cttttgggat 660
ttggggactt attttgaatc atcttacgct tttggtagaa aaatcatgac taaattgaac 720
tacattttgt ccattattga tgatacctac gatgcttacg gtactcacga agaattgtct 780
ttgttcaccg aagctgttgc tcgttggaac attgaagctg ttgacatgtt gccagattat 840
atgaagttaa tctacagaac tttgttggat acattcaacg aaatagaaga ggatatggct 900
aaacaaggta gatctcattg tgtaagatac gctaaagaag aaattcaaaa ggttattggt 960
gcttattacg ttcaagctaa gtggttttct gaaggttatg tccctactat tgaagaatac 1020
atgccaattg ctttgacttc ttgcgcttac agatttgtta ttaccaattc ttttttgggt 1080
atgggtgatt tcgctacaaa ggaagtattc gaatggattt ctggtaatcc aaaagttgtt 1140
aaatctgctt ctgttatttg tagattgatg gacgatatgc aaggacacga atttgaacaa 1200
aaaagaggtc acgttgcatc tgcaattgaa tgctatacta aacaacatgg tgtttccaag 1260
gaagaggcta tcaagatgtt cgaggaagag gttgctaacg cttggaagga tatcaatgaa 1320
gaattaatga tgaaaccacc agttgttgct agaccattgt taggtactat tttgaatttg 1380
gctagagcta tcgattttat ctataaagaa gatgacggtt acactcattc ttatttgatt 1440
aaggaacaaa tagcatctgt tttgggtgat catgttccat tttaa                 1485

<210> 757
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V184

<400> 757
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctctt 1080
tgtgtaagat acgctaaaga agaaattcac aaggttattg gtgactatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattggcaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aaggattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 758
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V186

<400> 758
atgccgcgtc gggatagggc gagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 759
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V187

<400> 759
atgtctttat cacatgacag tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 760
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V188

<400> 760
atgacgcgag gtatcctcaa aagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 761
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V189

<400> 761
atgttagata gtatcgcagg gagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 762
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V190

<400> 762
atgcatgagc cctctgagac tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 763
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V191

<400> 763
atgctaggcg tttctgaaca aagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 764
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V192

<400> 764
atgcgggtgg cgcctaaatt cagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggaagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggcg atcatgttcc attttaa                                     1647

<210> 765
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V193

<400> 765
atgagagctg aactgagcct tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 766
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V195

<400> 766
atgagggtga ttgatggcgg gagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 767
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V199

<400> 767
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattctag ccccaccgcc ccgcccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 768
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V201

<400> 768
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagatcgg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 769
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V203

<400> 769
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acgagttaac catgctttgt atagaccatt gagaaaaact 600
ttgtcaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gcgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaggaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 770
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V204

<400> 770
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttataatg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt gatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca cggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 771
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V205

<400> 771
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacgcatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 772
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V206

<400> 772
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaaaaaatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 773
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V207

<400> 773
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaacccaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaattgt ctttgttcac cgaagctgtt 960
gctcgttgga acattgaagc tgttgacatg ttgccagatt atatgaagtt aatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaagg tagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 774
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V222

<400> 774
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcatccctgg aacctccctt catgcacccc 660
tgcaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 775
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V223

<400> 775
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgagg ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcagcgatct atgcaaggac aggacgcatg 660
aacaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttgggtac ttattttgaa 840
ccacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 776
<211> 1641
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V242

<400> 776
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcaaggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag atacattatg tcaatctacg aagaggaggg atttaagaat 660
aagactttgt taaatttcgc taagttggat ttcaatattt tgttggattt gcataaagaa 720
gaattgaacg aattgactaa atggtggcaa gatttggatt ttactactaa attgccatat 780
gctagagata gattggttga attgtacttt tgggatttgg ggacttattt tgaatcacaa 840
tacgcttttg gtagaaaaat catgactaaa ttgaactaca ttttgtccat tattgatgat 900
acctacgatg cttacggtac tttggaagaa tgcacgatgt tcagtgaagc tgttgctcgt 960
tggaacattg aagctgttga tatgttgcca gattatatgc gaattatcta cagaactttg 1020
ttggatacat tcaacgaaat agaagaggat atggctaaac aacggagatc tcattgtgta 1080
agatacgcta aagaagaaat tcaaaaggtt attggtgctt attacgttca agctaagtgg 1140
ttttctgaag gttatgtccc tactattgaa gaatacatgc caattgcttt gacttcttgc 1200
gcttacagat ttgttattac caattctttt ttgggtatgg gtgatttcgc tacaaaggaa 1260
gtattcgaat ggatttctgg taatccaaaa gttgttaaat ctgcttctgt tatttgtaga 1320
ttgatggacg atatgcaagg acacgaattt gaacaaaaaa gaggtcacgt tgcatctgca 1380
attgaatgct atactaaaca acatggtgtt tccaaggaag aggctatcaa gatgttcgag 1440
gaagaggttg ctaacgcttg gaaggatatc aatgaagaat taatgatgaa accaccagtt 1500
gttgctagac cattgttagg tactattttg aatttggcta gagctatcga ttttatctat 1560
aaagaagatg acggttacac tcattcttat ttgattaagg aacaaatagc atctgttttg 1620
ggtgatcatg ttccatttta a                                           1641

<210> 777
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V243

<400> 777
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 778
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V244

<400> 778
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acactgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gaatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 779
<211> 1644
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V245

<400> 779
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcagtct accaagatga agctttccat 660
aacaagactt tgttaaattt cgctaagttg gatttcaata ttttgttgga tttgcataaa 720
gaagaattga acgaattgac taaatggtgg caagatttgg attttactac taaattgcca 780
tatgctagag atagattggt tgaattgtac ttttgggatt tggggactta ttttgaatca 840
caatacgctt ttggtagaaa aatcatgact aaattgaact acattttgtc cattattgat 900
gatacctacg atgcttacgg tactttggaa gaatgcacga tgttcagtga agctgttgct 960
cgttggaaca ttgaagctgt tgatatgttg ccagattata tgcgaattat ctacagaact 1020
ttgttggata cattcaacga aatagaagag gatatggcta aacaacggag atctcattgt 1080
gtaagatacg ctaaagaaga aattcaaaag gttattggtg cttattacgt tcaagctaag 1140
tggttttctg aaggttatgt ccctactatt gaagaataca tgccaattgc tttgacttct 1200
tgcgcttaca gatttgttat taccaattct tttttgggta tgggtgattt cgctacaaag 1260
gaagtattcg aatggatttc tggtaatcca aaagttgtta aatctgcttc tgttatttgt 1320
agattgatgg acgatatgca aggacacgaa tttgaacaaa aaagaggtca cgttgcatct 1380
gcaattgaat gctatactaa acaacatggt gtttccaagg aagaggctat caagatgttc 1440
gaggaagatg ttgctaacgc ttggaaggat atcaatgaag aattaatgat gaaaccacca 1500
gttgttgcta gaccattgtt aggtactatt ttgaatttgg ctagagctat cgattttatc 1560
tataaagaag atgacggtta cactcattct tatttgatta aggaacaaat agcatctgtt 1620
ttgggtgatc atgttccatt ttaa                                        1644

<210> 780
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V246

<400> 780
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtataggcc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatatt cacctaacgt tatcgaccta 660
gctccaaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg tacttatttt 840
gaaccacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat tgtctttgtt caccgaagct 960
gttgctcgtt ggaacattga agctgttgac atgttgccag attatatgaa gttaatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca aggtagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagaggttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 781
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V247

<400> 781
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaaagc ctgtgacgcg cagcctatcg 660
gcactgaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg tacttatttt 840
gaaccacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat tgtctttgtt caccgaagct 960
gctgctcgtt ggaacattga agctgttgac atgttgccag attatatgaa gttaatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca aggtagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagaggttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 782
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V248

<400> 782
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaatgc agcacttatg tttctcccgt 660
cataaaaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg tacttatttt 840
gaaccacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat tgtctttgtt caccgaagct 960
gttgctcgtt ggaacattga agctgttgac atgttgccag attatatgaa gttaatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca aggtagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagaggttgc taacgcttgg aaggatatca atgaagaatt aatgatgaag 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 783
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V249

<400> 783
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaggctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcattta attgtgtaaa atacgccttc 660
acccagaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg tacttatttt 840
gaaccacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat tgtctttgtt caccgaagct 960
gttgctcgtt ggaacattga agctgttgac atgttgccag attatatgaa gttaatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca aggtagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagaggttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 784
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V250

<400> 784
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatacc gtctaaatga taattacgca 660
gaatggaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg tacttatttt 840
gaaccacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat tgtctttgtt caccgaagct 960
gttgctcgtt ggaacattga agctgttgac atgttgccag attatatgaa gttaatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca aggtagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagaggttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 785
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V251

<400> 785
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc aggttttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaagattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcca aggcacaagc acatagcctc 660
gtgagtaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg tacttatttt 840
gaaccacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat tgtctttgtt caccgaagct 960
gttgctcgtt ggaacattga agctgttgac atgttgccag attatatgaa gttaatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca aggtagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagaggttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 786
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V252

<400> 786
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaagattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagtt tggtgcggtc tgagaaagat 660
ccaaataaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg tacttatttt 840
gaaccacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat tgtctttgtt caccgaagct 960
gttgctcgtt ggaacattga agctgttgac atgttgccag attatatgaa gttaatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca aggtagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagaggttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 787
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V253

<400> 787
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcacatc gcactccagc tttctgcaga 660
ggcgaaaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg tacttatttt 840
gaaccacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat tgtctttgtt caccgaagct 960
gttgctcgtt ggaacattga agctgttgac atgttgccag attatatgaa gttaatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca aggtagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagaggttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 788
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V254

<400> 788
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcacagg tgaggaagcg gtgtgtagaa 660
gcagtgaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg tacttatttt 840
gaaccacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat tgtctttgtt caccgaagct 960
gttgctcgtt ggaacattga agctgttgac atgttgccag attatatgaa gttaatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca aggtagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagaggttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 789
<211> 1644
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V255

<400> 789
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcagtct accaagatga agctttccat 660
aacaagactt tgttaaattt cgctaagttg gatttcaata ttttgttgga tttgcataaa 720
gaagaattga acgaattgac taaatggtgg caagatttgg attttactac taaattgcca 780
tatgctagag atagattggt tgaattgtac ttttgggatt tggggactta ttttgaatca 840
caatacgctt ttggtagaaa aatcatgact aaattgaact acattttgtc cattattgat 900
gatacctacg atgcttacgg tactttggaa gaatgcacga tgttcagtga agctgttgct 960
cgttggaaca ttgaagctgt tgatatgttg ccagattata tgcgaattat ctacagaact 1020
ttgttggata cattcaacga aatagaagag gatatggcta aacaacggag atctcattgt 1080
gtaagatacg ctaaagaaga aattcaaaag gttattggtg cttattacgt tcaagctaag 1140
tggttttctg aaggttatgt ccctactatt gaagaataca tgccaattgc tttgacttct 1200
tgcgcttaca gatttgttat taccaattct tttttgggta tgggtgattt cgctacaaag 1260
gaagtattcg aatggatttc tggtaatcca aaagttgtta aatctgcttc tgttatttgt 1320
agattgatgg acgatatgct aggacacgaa tttgaacaaa aaagaggtca cgttgcatct 1380
gcaattgaat gctatactaa acaacatggt gtttccaagg aagaggctat caagatgttc 1440
gaggaagatg ttgctaacgc ttggaaggat atcaatgaag aattaatgat gaaaccacca 1500
gttgttgcta gaccattgtt aggtactatt ttgaatttgg ctagagctat cgattttatc 1560
tataaagaag atgacggtta cactcattct tatttgatta aggaacaaat agcatctgtt 1620
ttgggtgatc atgttccatt ttaa                                        1644

<210> 790
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V256

<400> 790
atgcaaacgt ttaactgtgc tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 791
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V257

<400> 791
atggcaggcc ggggggcgtc cagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agagattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc catcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 792
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V258

<400> 792
atggttctca aatccaagcg cagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttgg caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 793
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V259 and V260

<400> 793
atgaaagaat gtacgatgtt aagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taagcaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 794
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutants V261 and V262

<400> 794
atgccatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 795
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V263

<400> 795
atgtgcatga caggtgaatc gagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 796
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V264

<400> 796
atgcagaatc ttggctactc gagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 797
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V265

<400> 797
atgttaaact caatcgattc gagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcctgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 798
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V266

<400> 798
atgcctgacc gcaccggacc aagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 799
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V267

<400> 799
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctcttcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 800
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V227

<400> 800
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt ccaattcata ttgattctga taaagctgat 300
ttgcatactg tttctttgca tttcagattg ttgagacaac aaggtattaa gatttcttgt 360
gatgttttcg aacaatttaa ggatgatgaa ggtagattca aaagttcttt gattaatgat 420
gttcagggca tgttgtcttt gtatgaagct gcttatatgg ctgttagagg tgaacatatt 480
ttggatgaag ctattgcatt tactactact catttgcaat cattggttgc acaagatcat 540
gttactccaa gattggctga acaaattaac catgctttgt atagaccatt gagaaaaact 600
ttgccaagat tggaagcaag ataccacatg tcaagaattg attctacttc tgatgatttg 660
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag aggttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 801
<211> 1587
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V268 (AA22-548)

<400> 801
tttttgcaag gtgcatcaga ttttaagact gttgatcata cagctacaaa tgaaagacat 60
gaagctttga aggaagaagt tagaagaatg attttagcaa ccggaaggaa accaattcaa 120
aaattgagat tgattgatga agttcaaaga ttgggtgttg cttaccattt tgaaaaagaa 180
attgaagata tgttggatca catttacaga gctgatcctt attttgaggc tcatgaatac 240
aatgatttgc atactgtttc tttgcatttc agattgttga gacaacaagg tattaagatt 300
tcttgtgatg ttttcgaaca atttaaggat gatgaaggta gattcaaaag ttctttgatt 360
aatgatgttc aaggcatgtt gtctttgtat gaagctgctt atatggctgt tagaggtgaa 420
catattttgg atgaagctat tgcatttact actactcatt tgcaatctgc agctccacat 480
ttgaagtcac ctttggctga acaaattaac catgctttgt atagaccatt gagaaaaact 540
ttgccaagat tggaagcaag atacgagatg tcaagaattg attctacttc tgatgatttg 600
gttaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 660
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 720
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 780
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 840
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 900
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 960
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1020
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1080
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1140
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1200
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1260
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1320
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1380
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1440
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1500
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1560
gttttgggtg atcatgttcc attttaa                                     1587

<210> 802
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V269

<400> 802
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattaggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt cgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacgaa atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 803
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V270

<400> 803
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatactta atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 804
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V271

<400> 804
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacacg atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 805
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V272

<400> 805
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcagcct ttctggcttg cggccgtcga 660
cccacaaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg tacttatttt 840
gaaccacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgac atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagaggttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 806
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V273

<400> 806
atggcaactt ctcacagtca gagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acactgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gaatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 807
<211> 1680
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V274

<400> 807
atgtctactc aagtctcagc atcttctcta gcccagattc cccaacccaa aaatcgtcct 60
gtggcaaact ttcaccccaa catttggggt gaccaattta tcacctacac tcctgaagac 120
aaggttactc gtgcctgcaa agaggagcag attgaagctt tgaaggaaga agttagaaga 180
atgattttag caaccggaag gaaaccaatt caaaaattga gattgattga tgaagttcaa 240
agattgggtg ttgcttacca ttttgaaaaa gaaattgaag atatgttgga tcacatttac 300
agagctgatc cttattttga ggctcatgaa tacaatgatt tgcatactgt ttctttgcat 360
ttcagattgt tgagacaaca aggtattaag atttcttgtg atgttttcga acaatttaag 420
gatgatgaag gtagattcaa aagttctttg attaatgatg ttcaaggcat gttgtctttg 480
tatgaagctg cttatatggc tgttagaggt gaacatattt tggatgaagc tattgcattt 540
actactactc atttgcaatc tgcagctcca catttgaagt cacctttggc tgaacaaatt 600
aaccatgctt tgtatagacc attgagaaaa actttgccaa gattggaagc aagatacatt 660
atgtcaagaa ttgattctac ttctgatgat ttggttaaca agactttgtt aaatttcgct 720
aagttggatt tcaatatttt gttggatttg cataaagaag aattgaacga attgactaaa 780
tggtggcaag atttggattt tactactaaa ttgccatatg ctagagatag attggttgaa 840
ttgtactttt gggatttggg gacttatttt gaatcacaat acgcttttgg tagaaaaatc 900
atgactaaat tgaactacat tttgtccatt attgatgata cctacgatgc ttacggtact 960
ttggaagaat gcacgatgtt cagtgaagct gttgctcgtt ggaacattga agctgttgat 1020
atgttgccag attatatgcg aattatctac agaactttgt tggatacatt caacgaaata 1080
gaagaggata tggctaaaca acggagatct cattgtgtaa gatacgctaa agaagaaatt 1140
caaaaggtta ttggtgctta ttacgttcaa gctaagtggt tttctgaagg ttatgtccct 1200
actattgaag aatacatgcc aattgctttg acttcttgcg cttacagatt tgttattacc 1260
aattcttttt tgggtatggg tgatttcgct acaaaggaag tattcgaatg gatttctggt 1320
aatccaaaag ttgttaaatc tgcttctgtt atttgtagat tgatggacga tatgcaagga 1380
cacgaatttg aacaaaaaag aggtcacgtt gcatctgcaa ttgaatgcta tactaaacaa 1440
catggtgttt ccaaggaaga ggctatcaag atgttcgagg aagatgttgc taacgcttgg 1500
aaggatatca atgaagaatt aatgatgaaa ccaccagttg ttgctagacc attgttaggt 1560
actattttga atttggctag agctatcgat tttatctata aagaagatga cggttacact 1620
cattcttatt tgattaagga acaaatagca tctgttttgg gtgatcatgt tccattttaa 1680


<210> 808
<211> 1653
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V275

<400> 808
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgcattaca acatatttgt aataattttc atgactgcaa tgatatggat 300
ggtgatttgc atactgtttc tttgcatttc agattgttga gacaacaagg tattaagatt 360
tcttgtgatg ttttcgaaca atttaaggat gatgaaggta gattcaaaag ttctttgatt 420
aatgatgttc aaggcatgtt gtctttgtat gaagctgctt atatggctgt tagaggtgaa 480
catattttgg atgaagctat tgcatttact actactcatt tgcaatcatt ggttgcacaa 540
gatcatgtta ctccaagatt ggctgaacaa attaaccatg ctttgtatag accattgaga 600
aaaactttgc caagattgga agcaagatac attatgtcaa gaattgattc tacttctgat 660
gatttggtta acaagacttt gttaaatttc gctaagttgg atttcaatat tttgttggat 720
ttgcataaag aagaattgaa cgaattgact aaatggtggc aagatttgga ttttactact 780
aaattgccat atgctagaga tagattggtt gaattgtact tttgggattt ggggacttat 840
tttgaatcac aatacgcttt tggtagaaaa atcatgacta aattgaacta cattttgtcc 900
attattgatg atacctacga tgcttacggt actttggaag aatgcacgat gttcagtgaa 960
gctgttgctc gttggaacat tgaagctgtt gatatgttgc cagattatat gcgaattatc 1020
tacagaactt tgttggatac attcaacgaa atagaagagg atatggctaa acaacggaga 1080
tctcattgtg taagatacgc taaagaagaa attcaaaagg ttattggtgc ttattacgtt 1140
caagctaagt ggttttctga aggttatgtc cctactattg aagaatacat gccaattgct 1200
ttgacttctt gcgcttacag atttgttatt accaattctt ttttgggtat gggtgatttc 1260
gctacaaagg aagtattcga atggatttct ggtaatccaa aagttgttaa atctgcttct 1320
gttatttgta gattgatgga cgatatgcaa ggacacgaat ttgaacaaaa aagaggtcac 1380
gttgcatctg caattgaatg ctatactaaa caacatggtg tttccaagga agaggctatc 1440
aagatgttcg aggaagaggt tgctaacgct tggaaggata tcaatgaaga attaatgatg 1500
aaaccaccag ttgttgctag accattgtta ggtactattt tgaatttggc tagagctatc 1560
gattttatct ataaagaaga tgacggttac actcattctt atttgattaa ggaacaaata 1620
gcatctgttt tgggtgatca tgttccattt taa                              1653

<210> 809
<211> 1653
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V276

<400> 809
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgcattaca acatatttgt aatagttttc atgactgcaa tgatatggat 300
ggtgatttgc atactgtttc tttgcatttc agattgttga gacaacaagg tattaagatt 360
tcttgtgatg ttttcgaaca atttaaggat gatgaaggta gattcaaaag ttctttgatt 420
aatgatgttc aaggcatgtt gtctctgtat gaagctgctt atatggctgt tagaggtgaa 480
catattttgg atgaagctat tgcatttact actactcatt tgcaatcatt ggttgcacaa 540
gatcatgtta ctccaagatt ggctgaacaa attaaccatg ctttgtatag accattgaga 600
aaaactttgc caagattgga agcaagatac attatgtcaa gaattgattc tacttctgat 660
gatttggtta acaagacttt gttaaatttc gctaagttgg atttcaatat tttgttggat 720
ttgcataaag aagaattgaa cgaattgact aaatggtggc aagatttgga ttttactact 780
aaattgccat atgctagaga tagattggtt gaattgtact tttgggattt ggggacttat 840
tttgaatcac aatacgcttt tggtagaaaa atcatgacta aattgaacta cattttgtcc 900
attattgatg atacctacga tgcttacggt actttggaag aatgcacgat gttcagtgaa 960
gctgttgctc gttggaacat tgaagctgtt gatatgttgc cagattatat gcgaattatc 1020
tacagaactt tgttggatac attcaacgaa atagaagagg atatggctaa acaacggaga 1080
tctcattgtg taagatacgc taaagaagaa attcaaaagg ttattggtgc ttattacgtt 1140
caagctaagt ggttttctga aggttgtgtc cctactattg aagaatacat gccaattgct 1200
ttgacttctt gcgcttacag atttgttatt accaattctt ttttgggtat gggtgatttc 1260
gctacaaagg aagtattcga atggatttct ggtaatccaa aagttgttaa atctgcttct 1320
gttatctgta gattgatgga cgatatgcaa ggacacgaat ttgaacaaaa aagaggtcac 1380
gttgcatctg caattgaatg ctatactaaa caacatggtg tttccaagga agaggctatc 1440
aagatgttcg aggaagaggt tgctaacgct tggaaggata tcaatgaaga attaatgatg 1500
aaaccaccag ttgttgctag accattgtta ggtactattt tgaatttggc tagagctatc 1560
gattttatct ataaagaaga tgacggttac actcattctt atttgattaa ggaacaaata 1620
gcatctgttt tgggtgatca tgttccattt taa                              1653

<210> 810
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V179

<400> 810
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Ser Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Pro Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 811
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V180 (AA100-548)

<400> 811
Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg Gln Gln Gly
 1               5                  10                  15      
Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp Asp Glu Gly
            20                  25                  30          
Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met Leu Ser Leu
        35                  40                  45              
Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile Leu Asp Glu
    50                  55                  60                  
Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val Ala Gln Asp
65                  70                  75                  80  
His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala Leu Tyr Arg
                85                  90                  95      
Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr Ile Met Ser
            100                 105                 110         
Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr Leu Leu Asn
        115                 120                 125             
Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His Lys Glu Glu
    130                 135                 140                 
Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr Thr Lys
145                 150                 155                 160 
Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp Asp Leu
                165                 170                 175     
Gly Thr Tyr Phe Glu Ser Ser Tyr Ala Phe Gly Arg Lys Ile Met Thr
            180                 185                 190         
Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp Ala Tyr
        195                 200                 205             
Gly Thr His Glu Glu Leu Ser Leu Phe Thr Lys Ala Val Ala Arg Trp
    210                 215                 220                 
Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys Leu Ile Tyr
225                 230                 235                 240 
Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp Met Ala Lys
                245                 250                 255     
Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu Ile Gln Lys
            260                 265                 270         
Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu Gly Tyr
        275                 280                 285             
Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser Cys Ala
    290                 295                 300                 
Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly Asp Phe Ala
305                 310                 315                 320 
Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys Val Val Lys
                325                 330                 335     
Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln Gly His Glu
            340                 345                 350         
Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr Thr
        355                 360                 365             
Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe Glu Glu
    370                 375                 380                 
Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met Met Lys
385                 390                 395                 400 
Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu Ala
                405                 410                 415     
Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His Ser
            420                 425                 430         
Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His Val Pro
        435                 440                 445             
Phe
    


<210> 812
<211> 494
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V181 (AA55-548)

<400> 812
Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg Leu Ile Asp Glu Val Gln
 1               5                  10                  15      
Arg Leu Gly Val Ala Tyr His Phe Glu Lys Glu Ile Glu Asp Ala Ile
            20                  25                  30          
Gln Gln Leu Cys Pro Ile His Ile Asp Ser Asp Lys Ala Asp Leu His
        35                  40                  45              
Thr Val Ser Leu His Phe Arg Leu Leu Arg Gln Gln Gly Ile Lys Ile
    50                  55                  60                  
Ser Cys Asp Val Phe Glu Gln Phe Lys Asp Asp Glu Gly Arg Phe Lys
65                  70                  75                  80  
Ser Ser Leu Ile Asn Asp Val Gln Gly Met Leu Ser Leu Tyr Glu Ala
                85                  90                  95      
Ala Tyr Met Ala Val Arg Gly Glu His Ile Leu Asp Glu Ala Ile Ala
            100                 105                 110         
Phe Thr Thr Thr His Leu Gln Ser Leu Val Ala Gln Asp His Val Thr
        115                 120                 125             
Pro Arg Leu Ala Glu Gln Ile Asn His Ala Leu Tyr Arg Pro Leu Arg
    130                 135                 140                 
Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr Ile Met Ser Arg Ile Asp
145                 150                 155                 160 
Ser Thr Ser Asp Asp Leu Val Asn Lys Thr Leu Leu Asn Phe Ala Lys
                165                 170                 175     
Leu Asp Phe Asn Ile Leu Leu Asp Leu His Lys Glu Glu Leu Asn Glu
            180                 185                 190         
Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr Thr Lys Leu Pro Tyr
        195                 200                 205             
Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp Asp Leu Gly Thr Tyr
    210                 215                 220                 
Phe Glu Ser Ser Tyr Ala Phe Gly Arg Lys Ile Met Thr Lys Leu Asn
225                 230                 235                 240 
Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp Ala Tyr Gly Thr His
                245                 250                 255     
Glu Glu Leu Ser Leu Phe Thr Glu Ala Val Ala Arg Trp Asn Ile Glu
            260                 265                 270         
Ala Val Asp Met Leu Pro Asp Tyr Met Lys Leu Ile Tyr Arg Thr Leu
        275                 280                 285             
Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp Met Ala Lys Gln Gly Arg
    290                 295                 300                 
Ser His Cys Val Arg Tyr Ala Lys Glu Glu Ile Gln Lys Val Ile Gly
305                 310                 315                 320 
Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu Gly Tyr Val Pro Thr
                325                 330                 335     
Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser Cys Ala Tyr Arg Phe
            340                 345                 350         
Val Ile Thr Asn Ser Phe Leu Gly Met Gly Asp Phe Ala Thr Lys Glu
        355                 360                 365             
Val Phe Glu Trp Ile Ser Gly Asn Pro Lys Val Val Lys Ser Ala Ser
    370                 375                 380                 
Val Ile Cys Arg Leu Met Asp Asp Met Gln Gly His Glu Phe Glu Gln
385                 390                 395                 400 
Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr Thr Lys Gln His
                405                 410                 415     
Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe Glu Glu Glu Val Ala
            420                 425                 430         
Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met Met Lys Pro Pro Val
        435                 440                 445             
Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu Ala Arg Ala Ile
    450                 455                 460                 
Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His Ser Tyr Leu Ile
465                 470                 475                 480 
Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His Val Pro Phe
                485                 490                 


<210> 813
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V184

<400> 813
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser Leu Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile His Lys Val Ile Gly Asp Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Gly Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Gly Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 814
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V186

<400> 814
Met Pro Arg Arg Asp Arg Ala Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 815
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V187

<400> 815
Met Ser Leu Ser His Asp Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 816
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V188

<400> 816
Met Thr Arg Gly Ile Leu Lys Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 817
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V189

<400> 817
Met Leu Asp Ser Ile Ala Gly Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 818
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V190

<400> 818
Met His Glu Pro Ser Glu Thr Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 819
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V191

<400> 819
Met Leu Gly Val Ser Glu Gln Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 820
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V192

<400> 820
Met Arg Val Ala Pro Lys Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 821
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V193

<400> 821
Met Arg Ala Glu Leu Ser Leu Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 822
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V195

<400> 822
Met Arg Val Ile Asp Gly Gly Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 823
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V199

<400> 823
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Pro Pro Pro Arg Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 824
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V201

<400> 824
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Asn Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Thr Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 825
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V203

<400> 825
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Arg Val Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Ser Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 826
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V204

<400> 826
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Asn Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Thr Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 827
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V205

<400> 827
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu Arg Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 828
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V206

<400> 828
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu Lys Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 829
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V207

<400> 829
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Pro Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 830
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V185

<400> 830
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile His Lys Val Ile Gly Asp Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Gly Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Gly Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 831
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V222

<400> 831
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Ser Leu Glu Pro Pro Phe Met His Pro Cys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 832
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V223

<400> 832
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Ala Ile Tyr Ala Arg Thr Gly Arg Met Asn Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 833
<211> 546
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V242

<400> 833
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Ile Met Ser Ile Tyr Glu Glu Glu Gly Phe Lys Asn Lys Thr Leu Leu
    210                 215                 220                 
Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His Lys Glu
225                 230                 235                 240 
Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr Thr
                245                 250                 255     
Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp Asp
            260                 265                 270         
Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys Ile Met
        275                 280                 285             
Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp Ala
    290                 295                 300                 
Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val Ala Arg
305                 310                 315                 320 
Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg Ile Ile
                325                 330                 335     
Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp Met Ala
            340                 345                 350         
Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu Ile Gln
        355                 360                 365             
Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu Gly
    370                 375                 380                 
Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser Cys
385                 390                 395                 400 
Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly Asp Phe
                405                 410                 415     
Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys Val Val
            420                 425                 430         
Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln Gly His
        435                 440                 445             
Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr
    450                 455                 460                 
Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe Glu
465                 470                 475                 480 
Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met Met
                485                 490                 495     
Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu
            500                 505                 510         
Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His
        515                 520                 525             
Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His Val
    530                 535                 540                 
Pro Phe
545     


<210> 834
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V243

<400> 834
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 835
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V244

<400> 835
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Thr Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 836
<211> 547
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V245

<400> 836
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Val Tyr Gln Asp Glu Ala Phe His Asn Lys Thr Leu
    210                 215                 220                 
Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His Lys
225                 230                 235                 240 
Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr
                245                 250                 255     
Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp
            260                 265                 270         
Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys Ile
        275                 280                 285             
Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp
    290                 295                 300                 
Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val Ala
305                 310                 315                 320 
Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg Ile
                325                 330                 335     
Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp Met
            340                 345                 350         
Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu Ile
        355                 360                 365             
Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu
    370                 375                 380                 
Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser
385                 390                 395                 400 
Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly Asp
                405                 410                 415     
Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys Val
            420                 425                 430         
Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln Gly
        435                 440                 445             
His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys
    450                 455                 460                 
Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe
465                 470                 475                 480 
Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met
                485                 490                 495     
Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn
            500                 505                 510         
Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr
        515                 520                 525             
His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His
    530                 535                 540                 
Val Pro Phe
545         


<210> 837
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V246

<400> 837
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Tyr Ser Pro Asn Val Ile Asp Leu Ala Pro Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Lys Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 838
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V247

<400> 838
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Lys Pro Val Thr Arg Ser Leu Ser Ala Leu Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala
305                 310                 315                 320 
Ala Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Lys Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 839
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V248

<400> 839
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Met Gln His Leu Cys Phe Ser Arg His Lys Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Lys Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 840
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V249

<400> 840
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Phe Asn Cys Val Lys Tyr Ala Phe Thr Gln Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Lys Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 841
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V250

<400> 841
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Tyr Arg Leu Asn Asp Asn Tyr Ala Glu Trp Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Lys Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 842
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V251

<400> 842
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Gly Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Arg Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Lys Ala Gln Ala His Ser Leu Val Ser Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Lys Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 843
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V252

<400> 843
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Arg Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Leu Val Arg Ser Glu Lys Asp Pro Asn Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Lys Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 844
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V253

<400> 844
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser His Arg Thr Pro Ala Phe Cys Arg Gly Glu Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Lys Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 845
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V254

<400> 845
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Gln Val Arg Lys Arg Cys Val Glu Ala Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Lys Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 846
<211> 547
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V255

<400> 846
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Val Tyr Gln Asp Glu Ala Phe His Asn Lys Thr Leu
    210                 215                 220                 
Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His Lys
225                 230                 235                 240 
Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr
                245                 250                 255     
Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp
            260                 265                 270         
Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys Ile
        275                 280                 285             
Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp
    290                 295                 300                 
Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val Ala
305                 310                 315                 320 
Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg Ile
                325                 330                 335     
Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp Met
            340                 345                 350         
Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu Ile
        355                 360                 365             
Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu
    370                 375                 380                 
Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser
385                 390                 395                 400 
Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly Asp
                405                 410                 415     
Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys Val
            420                 425                 430         
Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Leu Gly
        435                 440                 445             
His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys
    450                 455                 460                 
Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe
465                 470                 475                 480 
Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met
                485                 490                 495     
Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn
            500                 505                 510         
Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr
        515                 520                 525             
His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His
    530                 535                 540                 
Val Pro Phe
545         


<210> 847
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> SCVS mutant V256

<400> 847
Met Gln Thr Phe Asn Cys Ala Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 848
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V257

<400> 848
Met Ala Gly Arg Gly Ala Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 849
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V258

<400> 849
Met Val Leu Lys Ser Lys Arg Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 850
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V259 and V260

<400> 850
Met Lys Glu Cys Thr Met Leu Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 851
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutants V261 and V262

<400> 851
Met Pro Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 852
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V263

<400> 852
Met Cys Met Thr Gly Glu Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 853
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V264

<400> 853
Met Gln Asn Leu Gly Tyr Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 854
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V265

<400> 854
Met Leu Asn Ser Ile Asp Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 855
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V266

<400> 855
Met Pro Asp Arg Thr Gly Pro Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 856
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V267

<400> 856
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 857
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V227

<400> 857
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Pro Ile His Ile Asp Ser
                85                  90                  95      
Asp Lys Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
His Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 858
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V268

<400> 858
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Glu Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 859
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V269

<400> 859
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Ser Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Glu Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 860
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V270

<400> 860
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Leu Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 861
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V271

<400> 861
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Thr Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 862
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V272

<400> 862
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ala Phe Leu Ala Cys Gly Arg Arg Pro Thr Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 863
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V273

<400> 863
Met Ala Thr Ser His Ser Gln Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Thr Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 864
<211> 559
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V274

<400> 864
Met Ser Thr Gln Val Ser Ala Ser Ser Leu Ala Gln Ile Pro Gln Pro
 1               5                  10                  15      
Lys Asn Arg Pro Val Ala Asn Phe His Pro Asn Ile Trp Gly Asp Gln
            20                  25                  30          
Phe Ile Thr Tyr Thr Pro Glu Asp Lys Val Thr Arg Ala Cys Lys Glu
        35                  40                  45              
Glu Gln Ile Glu Ala Leu Lys Glu Glu Val Arg Arg Met Ile Leu Ala
    50                  55                  60                  
Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg Leu Ile Asp Glu Val Gln
65                  70                  75                  80  
Arg Leu Gly Val Ala Tyr His Phe Glu Lys Glu Ile Glu Asp Met Leu
                85                  90                  95      
Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe Glu Ala His Glu Tyr Asn
            100                 105                 110         
Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg Gln Gln Gly
        115                 120                 125             
Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp Asp Glu Gly
    130                 135                 140                 
Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met Leu Ser Leu
145                 150                 155                 160 
Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile Leu Asp Glu
                165                 170                 175     
Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Ala Ala Pro His Leu
            180                 185                 190         
Lys Ser Pro Leu Ala Glu Gln Ile Asn His Ala Leu Tyr Arg Pro Leu
        195                 200                 205             
Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr Ile Met Ser Arg Ile
    210                 215                 220                 
Asp Ser Thr Ser Asp Asp Leu Val Asn Lys Thr Leu Leu Asn Phe Ala
225                 230                 235                 240 
Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His Lys Glu Glu Leu Asn
                245                 250                 255     
Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr Thr Lys Leu Pro
            260                 265                 270         
Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp Asp Leu Gly Thr
        275                 280                 285             
Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys Ile Met Thr Lys Leu
    290                 295                 300                 
Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp Ala Tyr Gly Thr
305                 310                 315                 320 
Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val Ala Arg Trp Asn Ile
                325                 330                 335     
Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg Ile Ile Tyr Arg Thr
            340                 345                 350         
Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp Met Ala Lys Gln Arg
        355                 360                 365             
Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu Ile Gln Lys Val Ile
    370                 375                 380                 
Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu Gly Tyr Val Pro
385                 390                 395                 400 
Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser Cys Ala Tyr Arg
                405                 410                 415     
Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly Asp Phe Ala Thr Lys
            420                 425                 430         
Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys Val Val Lys Ser Ala
        435                 440                 445             
Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln Gly His Glu Phe Glu
    450                 455                 460                 
Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr Thr Lys Gln
465                 470                 475                 480 
His Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe Glu Glu Asp Val
                485                 490                 495     
Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met Met Lys Pro Pro
            500                 505                 510         
Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu Ala Arg Ala
        515                 520                 525             
Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His Ser Tyr Leu
    530                 535                 540                 
Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His Val Pro Phe
545                 550                 555                 


<210> 865
<211> 550
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V275

<400> 865
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Leu Gln His Ile Cys Asn Asn Phe His Asp Cys
                85                  90                  95      
Asn Asp Met Asp Gly Asp Leu His Thr Val Ser Leu His Phe Arg Leu
            100                 105                 110         
Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe
        115                 120                 125             
Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln
    130                 135                 140                 
Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu
145                 150                 155                 160 
His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser
                165                 170                 175     
Leu Val Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn
            180                 185                 190         
His Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala
        195                 200                 205             
Arg Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn
    210                 215                 220                 
Lys Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp
225                 230                 235                 240 
Leu His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu
                245                 250                 255     
Asp Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu
            260                 265                 270         
Tyr Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly
        275                 280                 285             
Arg Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp
    290                 295                 300                 
Thr Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu
305                 310                 315                 320 
Ala Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr
                325                 330                 335     
Met Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu
            340                 345                 350         
Glu Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys
        355                 360                 365             
Glu Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp
    370                 375                 380                 
Phe Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala
385                 390                 395                 400 
Leu Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly
                405                 410                 415     
Met Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn
            420                 425                 430         
Pro Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp
        435                 440                 445             
Met Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala
    450                 455                 460                 
Ile Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile
465                 470                 475                 480 
Lys Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu
                485                 490                 495     
Glu Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr
            500                 505                 510         
Ile Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp
        515                 520                 525             
Gly Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu
    530                 535                 540                 
Gly Asp His Val Pro Phe
545                 550 


<210> 866
<211> 550
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V276

<400> 866
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Leu Gln His Ile Cys Asn Ser Phe His Asp Cys
                85                  90                  95      
Asn Asp Met Asp Gly Asp Leu His Thr Val Ser Leu His Phe Arg Leu
            100                 105                 110         
Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe
        115                 120                 125             
Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln
    130                 135                 140                 
Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu
145                 150                 155                 160 
His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser
                165                 170                 175     
Leu Val Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn
            180                 185                 190         
His Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala
        195                 200                 205             
Arg Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn
    210                 215                 220                 
Lys Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp
225                 230                 235                 240 
Leu His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu
                245                 250                 255     
Asp Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu
            260                 265                 270         
Tyr Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly
        275                 280                 285             
Arg Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp
    290                 295                 300                 
Thr Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu
305                 310                 315                 320 
Ala Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr
                325                 330                 335     
Met Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu
            340                 345                 350         
Glu Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys
        355                 360                 365             
Glu Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp
    370                 375                 380                 
Phe Ser Glu Gly Cys Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala
385                 390                 395                 400 
Leu Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly
                405                 410                 415     
Met Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn
            420                 425                 430         
Pro Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp
        435                 440                 445             
Met Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala
    450                 455                 460                 
Ile Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile
465                 470                 475                 480 
Lys Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu
                485                 490                 495     
Glu Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr
            500                 505                 510         
Ile Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp
        515                 520                 525             
Gly Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu
    530                 535                 540                 
Gly Asp His Val Pro Phe
545                 550 


<210> 867
<211> 39
<212> PRT
<213> Citrus sinensis

<220> 
<223> CVS3-41

<400> 867
Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser Leu Trp
 1               5                  10                  15      
Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val Asp His
            20                  25                  30          
Thr Ala Thr Gln Glu Arg His
        35                  


<210> 868
<211> 6
<212> PRT
<213> Citrus sinensis

<220> 
<223> CVS53-58

<400> 868
Thr Asp Ala Glu Asp Lys
 1               5      


<210> 869
<211> 15
<212> PRT
<213> Citrus sinensis

<220> 
<223> CVS85-99

<400> 869
Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser Asn Arg Ala
 1               5                  10                  15  


<210> 870
<211> 11
<212> PRT
<213> Citrus sinensis

<220> 
<223> CVS174-184

<400> 870
Ser Leu Val Ala Gln Asp His Val Thr Pro Lys
 1               5                  10      


<210> 871
<211> 10
<212> PRT
<213> Citrus sinensis

<220> 
<223> CVS212-221

<400> 871
Met Ile Asn Ser Thr Ser Asp His Leu Tyr
 1               5                  10  


<210> 872
<211> 49
<212> PRT
<213> Vitis vinifera

<220> 
<223> Vitis vinifera amino acids 3-51

<400> 872
Thr Gln Val Ser Ala Ser Ser Leu Ala Gln Ile Pro Gln Pro Lys Asn
 1               5                  10                  15      
Arg Pro Val Ala Asn Phe His Pro Asn Ile Trp Gly Asp Gln Phe Ile
            20                  25                  30          
Thr Tyr Thr Pro Glu Asp Lys Val Thr Arg Ala Cys Lys Glu Glu Gln
        35                  40                  45              
Ile
    


<210> 873
<211> 6
<212> PRT
<213> Nicotiana tabacum

<220> 
<223> TEAS 58-63

<400> 873
Leu Ala Thr Gly Arg Lys
 1               5      


<210> 874
<211> 18
<212> PRT
<213> Hyoscyamus muticus

<220> 
<223> HPS 93-110

<400> 874
Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe Glu Ala His Glu
 1               5                  10                  15      
Tyr Asn
        


<210> 875
<211> 17
<212> PRT
<213> Vitis vinifera

<220> 
<223> Vitis vinifera 96-112

<400> 875
Ala Leu Gln His Ile Cys Asn Ser Phe His Asp Cys Asn Asp Met Asp
 1               5                  10                  15      
Gly
    


<210> 876
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Vitis vinifera 96-112 with S103N

<400> 876
Ala Leu Gln His Ile Cys Asn Asn Phe His Asp Cys Asn Asp Met Asp
 1               5                  10                  15      
Gly
    


<210> 877
<211> 9
<212> PRT
<213> Hyoscyamus muticus

<220> 
<223> HPS 185-193

<400> 877
Ser Ala Ala Pro His Leu Lys Ser Pro
 1               5                  


<210> 878
<211> 8
<212> PRT
<213> Hyoscyamus muticus

<220> 
<223> HPS 221-228

<400> 878
Ile Tyr Glu Glu Glu Glu Phe Lys
 1               5              


<210> 879
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HPS 221-228 with E226G mutation

<400> 879
Ile Tyr Glu Glu Glu Gly Phe Lys
 1               5              


<210> 880
<211> 9
<212> PRT
<213> Nicotiana tabacum

<220> 
<223> TEAS 213-221

<400> 880
Ser Ile Tyr Asp Lys Glu Gln Ser Lys
 1               5                  


<210> 881
<211> 8
<212> PRT
<213> Vitis vinifera

<220> 
<223> Vitis vinifera 223-230

<400> 881
Val Tyr Gln Asp Glu Ala Phe His
 1               5              


<210> 882
<211> 589
<212> PRT
<213> Chamaecyparis nootkatensis

<220> 
<223> valencene synthase

<400> 882
Met Ala Glu Met Phe Asn Gly Asn Ser Ser Asn Asp Gly Ser Ser Cys
 1               5                  10                  15      
Met Pro Val Lys Asp Ala Leu Arg Arg Thr Gly Asn His His Pro Asn
            20                  25                  30          
Leu Trp Thr Asp Asp Phe Ile Gln Ser Leu Asn Ser Pro Tyr Ser Asp
        35                  40                  45              
Ser Ser Tyr His Lys His Arg Glu Ile Leu Ile Asp Glu Ile Arg Asp
    50                  55                  60                  
Met Phe Ser Asn Gly Glu Gly Asp Glu Phe Gly Val Leu Glu Asn Ile
65                  70                  75                  80  
Trp Phe Val Asp Val Val Gln Arg Leu Gly Ile Asp Arg His Phe Gln
                85                  90                  95      
Glu Glu Ile Lys Thr Ala Leu Asp Tyr Ile Tyr Lys Phe Trp Asn His
            100                 105                 110         
Asp Ser Ile Phe Gly Asp Leu Asn Met Val Ala Leu Gly Phe Arg Ile
        115                 120                 125             
Leu Arg Leu Asn Arg Tyr Val Ala Ser Ser Asp Val Phe Lys Lys Phe
    130                 135                 140                 
Lys Gly Glu Glu Gly Gln Phe Ser Gly Phe Glu Ser Ser Asp Gln Asp
145                 150                 155                 160 
Ala Lys Leu Glu Met Met Leu Asn Leu Tyr Lys Ala Ser Glu Leu Asp
                165                 170                 175     
Phe Pro Asp Glu Asp Ile Leu Lys Glu Ala Arg Ala Phe Ala Ser Met
            180                 185                 190         
Tyr Leu Lys His Val Ile Lys Glu Tyr Gly Asp Ile Gln Glu Ser Lys
        195                 200                 205             
Asn Pro Leu Leu Met Glu Ile Glu Tyr Thr Phe Lys Tyr Pro Trp Arg
    210                 215                 220                 
Cys Arg Leu Pro Arg Leu Glu Ala Trp Asn Phe Ile His Ile Met Arg
225                 230                 235                 240 
Gln Gln Asp Cys Asn Ile Ser Leu Ala Asn Asn Leu Tyr Lys Ile Pro
                245                 250                 255     
Lys Ile Tyr Met Lys Lys Ile Leu Glu Leu Ala Ile Leu Asp Phe Asn
            260                 265                 270         
Ile Leu Gln Ser Gln His Gln His Glu Met Lys Leu Ile Ser Thr Trp
        275                 280                 285             
Trp Lys Asn Ser Ser Ala Ile Gln Leu Asp Phe Phe Arg His Arg His
    290                 295                 300                 
Ile Glu Ser Tyr Phe Trp Trp Ala Ser Pro Leu Phe Glu Pro Glu Phe
305                 310                 315                 320 
Ser Thr Cys Arg Ile Asn Cys Thr Lys Leu Ser Thr Lys Met Phe Leu
                325                 330                 335     
Leu Asp Asp Ile Tyr Asp Thr Tyr Gly Thr Val Glu Glu Leu Lys Pro
            340                 345                 350         
Phe Thr Thr Thr Leu Thr Arg Trp Asp Val Ser Thr Val Asp Asn His
        355                 360                 365             
Pro Asp Tyr Met Lys Ile Ala Phe Asn Phe Ser Tyr Glu Ile Tyr Lys
    370                 375                 380                 
Glu Ile Ala Ser Glu Ala Glu Arg Lys His Gly Pro Phe Val Tyr Lys
385                 390                 395                 400 
Tyr Leu Gln Ser Cys Trp Lys Ser Tyr Ile Glu Ala Tyr Met Gln Glu
                405                 410                 415     
Ala Glu Trp Ile Ala Ser Asn His Ile Pro Gly Phe Asp Glu Tyr Leu
            420                 425                 430         
Met Asn Gly Val Lys Ser Ser Gly Met Arg Ile Leu Met Ile His Ala
        435                 440                 445             
Leu Ile Leu Met Asp Thr Pro Leu Ser Asp Glu Ile Leu Glu Gln Leu
    450                 455                 460                 
Asp Ile Pro Ser Ser Lys Ser Gln Ala Leu Leu Ser Leu Ile Thr Arg
465                 470                 475                 480 
Leu Val Asp Asp Val Lys Asp Phe Glu Asp Glu Gln Ala His Gly Glu
                485                 490                 495     
Met Ala Ser Ser Ile Glu Cys Tyr Met Lys Asp Asn His Gly Ser Thr
            500                 505                 510         
Arg Glu Asp Ala Leu Asn Tyr Leu Lys Ile Arg Ile Glu Ser Cys Val
        515                 520                 525             
Gln Glu Leu Asn Lys Glu Leu Leu Glu Pro Ser Asn Met His Gly Ser
    530                 535                 540                 
Phe Arg Asn Leu Tyr Leu Asn Val Gly Met Arg Val Ile Phe Phe Met
545                 550                 555                 560 
Leu Asn Asp Gly Asp Leu Phe Thr His Ser Asn Arg Lys Glu Ile Gln
                565                 570                 575     
Asp Ala Ile Thr Lys Phe Phe Val Glu Pro Ile Ile Pro
            580                 585                 


<210> 883
<211> 589
<212> PRT
<213> Chamaecyparis nootkatensis

<220> 
<223> valencene synthase

<400> 883
Met Ala Glu Met Phe Asn Gly Asn Ser Ser Asn Asp Gly Ser Ser Cys
 1               5                  10                  15      
Met Pro Val Lys Asp Ala Leu Arg Arg Thr Gly Asn His His Pro Asn
            20                  25                  30          
Leu Trp Thr Asp Asp Phe Ile Gln Ser Leu Asn Ser Pro Tyr Ser Asp
        35                  40                  45              
Ser Ser Tyr His Lys His Arg Glu Ile Leu Ile Asp Glu Ile Arg Asp
    50                  55                  60                  
Met Phe Ser Asn Gly Glu Gly Asp Glu Phe Gly Val Leu Glu Asn Ile
65                  70                  75                  80  
Trp Phe Val Asp Val Val Gln Arg Leu Gly Ile Asp Arg His Phe Gln
                85                  90                  95      
Glu Glu Ile Lys Thr Ala Leu Asp Tyr Ile Tyr Lys Phe Trp Asn His
            100                 105                 110         
Asp Ser Ile Phe Gly Asp Leu Asn Met Val Ala Leu Gly Phe Arg Ile
        115                 120                 125             
Leu Arg Leu Asn Arg Tyr Val Ala Ser Ser Asp Val Phe Lys Lys Phe
    130                 135                 140                 
Lys Gly Glu Glu Gly Gln Phe Ser Gly Phe Glu Ser Ser Asp Gln Asp
145                 150                 155                 160 
Ala Lys Leu Glu Met Met Leu Asn Leu Tyr Lys Ala Ser Glu Leu Asp
                165                 170                 175     
Phe Pro Asp Glu Asp Ile Leu Lys Glu Ala Arg Ala Phe Ala Ser Met
            180                 185                 190         
Tyr Leu Lys His Val Ile Lys Glu Tyr Gly Asp Ile Gln Glu Ser Lys
        195                 200                 205             
Asn Pro Leu Leu Met Glu Ile Glu Tyr Thr Phe Lys Tyr Pro Trp Arg
    210                 215                 220                 
Cys Arg Leu Pro Arg Leu Glu Ala Trp Asn Phe Ile His Ile Met Arg
225                 230                 235                 240 
Gln Gln Asp Cys Asn Ile Ser Leu Ala Asn Asn Leu Tyr Lys Ile Pro
                245                 250                 255     
Lys Ile Tyr Met Lys Lys Ile Leu Glu Leu Ala Ile Leu Asp Phe Asn
            260                 265                 270         
Ile Leu Gln Ser Gln His Gln His Glu Met Lys Leu Ile Ser Thr Trp
        275                 280                 285             
Trp Lys Asn Ser Ser Ala Ile Gln Leu Asp Phe Phe Arg His Arg His
    290                 295                 300                 
Ile Glu Ser Tyr Phe Trp Trp Ala Ser Pro Leu Phe Glu Pro Glu Phe
305                 310                 315                 320 
Ser Thr Cys Arg Ile Asn Cys Thr Lys Leu Ser Thr Lys Met Phe Leu
                325                 330                 335     
Leu Asp Asp Ile Tyr Asp Thr Tyr Gly Thr Val Glu Glu Leu Lys Pro
            340                 345                 350         
Phe Thr Thr Thr Leu Thr Arg Trp Asp Val Ser Thr Val Asp Asn His
        355                 360                 365             
Pro Asp Tyr Met Lys Ile Ala Phe Asn Phe Ser Tyr Glu Ile Tyr Lys
    370                 375                 380                 
Glu Ile Ala Ser Glu Ala Glu Arg Lys His Gly Pro Phe Val Tyr Lys
385                 390                 395                 400 
Tyr Leu Gln Ser Cys Trp Lys Ser Tyr Ile Glu Ala Tyr Met Gln Glu
                405                 410                 415     
Ala Glu Trp Ile Ala Ser Asn His Ile Pro Gly Phe Asp Glu Tyr Leu
            420                 425                 430         
Met Asn Gly Val Lys Ser Ser Gly Met Arg Ile Leu Met Ile His Ala
        435                 440                 445             
Leu Ile Leu Met Asp Thr Pro Leu Ser Asp Glu Ile Leu Glu Gln Leu
    450                 455                 460                 
Asp Ile Pro Ser Ser Lys Ser Gln Ala Leu Leu Ser Leu Ile Thr Arg
465                 470                 475                 480 
Leu Val Asp Asp Val Lys Asp Phe Glu Asp Glu Gln Ala His Gly Glu
                485                 490                 495     
Met Ala Ser Ser Ile Glu Cys Tyr Met Lys Asp Asn His Gly Ser Thr
            500                 505                 510         
Arg Glu Asp Ala Leu Asn Tyr Leu Lys Ile Arg Ile Glu Ser Cys Val
        515                 520                 525             
Gln Glu Leu Asn Lys Glu Leu Leu Glu Pro Ser Asn Met His Gly Ser
    530                 535                 540                 
Phe Arg Asn Leu Tyr Leu Asn Val Gly Met Arg Val Ile Phe Phe Met
545                 550                 555                 560 
Leu Asn Asp Gly Asp Leu Phe Thr His Ser Asn Arg Lys Glu Ile Gln
                565                 570                 575     
Asp Ala Ile Thr Lys Phe Phe Val Glu Pro Ile Ile Pro
            580                 585                 


<210> 884
<211> 1722
<212> DNA
<213> Chamaecyparis nootkatensis

<220> 
<223> valencene synthase

<400> 884
atgcccgtga aggacgccct tcgtcggact ggaaatcatc atcctaactt gtggactgat 60
gatttcatac agtccctcaa ttctccatat tcggattctt cataccataa acatagggaa 120
atactaattg atgagattcg tgatatgttt tctaatggag aaggcgatga gttcggtgta 180
cttgaaaata tttggtttgt tgatgttgta caacgtttgg gaatagatcg acattttcaa 240
gaggaaatca aaactgcact tgattatatc tacaagttct ggaatcatga tagtattttt 300
ggcgatctca acatggtggc tctaggattt cggatactac gactgaatag atatgtcgct 360
tcttcagatg tttttaaaaa gttcaaaggt gaagaaggac aattctctgg ttttgaatct 420
agcgatcaag atgcaaaatt agaaatgatg ttaaatttat ataaagcttc agaattagat 480
tttcctgatg aagatatctt aaaagaagca agagcgtttg cttctatgta cctgaaacat 540
gttatcaaag aatatggtga catacaagaa tcaaaaaatc cacttctaat ggagatagag 600
tacactttta aatatccttg gagatgtagg cttccaaggt tggaggcttg gaactttatt 660
catataatga gacaacaaga ttgcaatata tcacttgcca ataaccttta taaaattcca 720
aaaatatata tgaaaaagat attggaacta gcaatactgg acttcaatat tttgcagtca 780
caacatcaac atgaaatgaa attaatatcc acatggtgga aaaattcaag tgcaattcaa 840
ttggatttct ttcggcatcg tcacatagaa agttattttt ggtgggctag tccattattt 900
gaacctgagt tcagtacatg tagaattaat tgtaccaaat tatctacaaa aatgttcctc 960
cttgacgata tttatgacac atatgggact gttgaggaat tgaaaccatt cacaacaaca 1020
ttaacaagat gggatgtttc cacagttgat aatcatccag actacatgaa aattgctttc 1080
aatttttcat atgagatata taaggaaatt gcaagtgaag ccgaaagaaa gcatggtccc 1140
tttgtttaca aataccttca atcttgctgg aagagttata tcgaggctta tatgcaagaa 1200
gcagaatgga tagcttctaa tcatatacca ggttttgatg aatacttgat gaatggagta 1260
aaaagtagcg gcatgcgaat tctaatgata catgcactaa tactaatgga tactccttta 1320
tctgatgaaa ttttggagca acttgatatc ccatcatcca agtcgcaagc tcttctatca 1380
ttaattactc gactagtgga tgatgtcaaa gactttgagg atgaacaagc tcatggggag 1440
atggcatcaa gtatagagtg ctacatgaaa gacaaccatg gttctacaag ggaagatgct 1500
ttgaattatc tcaaaattcg tatagagagt tgtgtgcaag agttaaataa ggagcttctc 1560
gagccttcaa atatgcatgg atcttttaga aacctatatc tcaatgttgg catgcgagta 1620
atatttttta tgctcaatga tggtgatctc tttacacact ccaatagaaa agagatacaa 1680
gatgcaataa caaaattttt tgtggaacca atcattccat ag                    1722

<210> 885
<211> 1770
<212> DNA
<213> Chamaecyparis nootkatensis

<220> 
<223> valencene synthase

<400> 885
atggctgaaa tgtttaatgg aaattccagc aatgatggaa gttcttgcat gcccgtgaag 60
gacgcccttc gtcggactgg aaatcatcat cctaacttgt ggactgatga tttcatacag 120
tccctcaatt ctccatattc ggattcttca taccataaac atagggaaat actaattgat 180
gagattcgtg atatgttttc taatggagaa ggcgatgagt tcggtgtact tgaaaatatt 240
tggtttgttg atgttgtaca acgtttggga atagatcgac attttcaaga ggaaatcaaa 300
actgcacttg attatatcta caagttctgg aatcatgata gtatttttgg cgatctcaac 360
atggtggctc taggatttcg gatactacga ctgaatagat atgtcgcttc ttcagatgtt 420
tttaaaaagt tcaaaggtga agaaggacaa ttctctggtt ttgaatctag cgatcaagat 480
gcaaaattag aaatgatgtt aaatttatat aaagcttcag aattagattt tcctgatgaa 540
gatatcttaa aagaagcaag agcgtttgct tctatgtacc tgaaacatgt tatcaaagaa 600
tatggtgaca tacaagaatc aaaaaatcca cttctaatgg agatagagta cacttttaaa 660
tatccttgga gatgtaggct tccaaggttg gaggcttgga actttattca tataatgaga 720
caacaagatt gcaatatatc acttgccaat aacctttata aaattccaaa aatatatatg 780
aaaaagatat tggaactagc aatactggac ttcaatattt tgcagtcaca acatcaacat 840
gaaatgaaat taatatccac atggtggaaa aattcaagtg caattcaatt ggatttcttt 900
cggcatcgtc acatagaaag ttatttttgg tgggctagtc cattatttga acctgagttc 960
agtacatgta gaattaattg taccaaatta tctacaaaaa tgttcctcct tgacgatatt 1020
tatgacacat atgggactgt tgaggaattg aaaccattca caacaacatt aacaagatgg 1080
gatgtttcca cagttgataa tcatccagac tacatgaaaa ttgctttcaa tttttcatat 1140
gagatatata aggaaattgc aagtgaagcc gaaagaaagc atggtccctt tgtttacaaa 1200
taccttcaat cttgctggaa gagttatatc gaggcttata tgcaagaagc agaatggata 1260
gcttctaatc atataccagg ttttgatgaa tacttgatga atggagtaaa aagtagcggc 1320
atgcgaattc taatgataca tgcactaata ctaatggata ctcctttatc tgatgaaatt 1380
ttggagcaac ttgatatccc atcatccaag tcgcaagctc ttctatcatt aattactcga 1440
ctagtggatg atgtcaaaga ctttgaggat gaacaagctc atggggagat ggcatcaagt 1500
atagagtgct acatgaaaga caaccatggt tctacaaggg aagatgcttt gaattatctc 1560
aaaattcgta tagagagttg tgtgcaagag ttaaataagg agcttctcga gccttcaaat 1620
atgcatggat cttttagaaa cctatatctc aatgttggca tgcgagtaat attttttatg 1680
ctcaatgatg gtgatctctt tacacactcc aatagaaaag agatacaaga tgcaataaca 1740
aaattttttg tggaaccaat cattccatag                                  1770

<210> 886
<211> 548
<212> PRT
<213> Citrus sinensis

<220> 
<223> Valencene synthase A517I, I518V

<400> 886
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Lys Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Gln Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Gly Asp Ala Ile Gln Lys Leu Cys Pro Ile Tyr Ile Asp Ser
                85                  90                  95      
Asn Arg Ala Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg
            100                 105                 110         
Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp
        115                 120                 125             
Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met
    130                 135                 140                 
Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile
145                 150                 155                 160 
Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Lys Ser Leu Val
                165                 170                 175     
Ala Gln Asp His Val Thr Pro Lys Leu Ala Glu Gln Ile Asn His Ala
            180                 185                 190         
Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr
        195                 200                 205             
Phe Met Ser Met Ile Asn Ser Thr Ser Asp His Leu Cys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Glu Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Gln Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu Ala Val
305                 310                 315                 320 
Gln Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Glu Tyr Met Lys
                325                 330                 335     
Leu Ile Tyr Arg Thr Leu Leu Asp Ala Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Asn Gln Lys Val Ile Gly Ala Tyr Ser Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Thr Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Asn Asn Pro Lys
            420                 425                 430         
Val Val Lys Ala Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Thr Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ile Val Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Asp Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 887
<211> 557
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V277

<400> 887
Met Ser Thr Gln Val Ser Ala Ser Ser Leu Ala Gln Ile Pro Gln Pro
 1               5                  10                  15      
Lys Asn Arg Pro Val Ala Asn Phe His Pro Asn Ile Trp Gly Asp Gln
            20                  25                  30          
Phe Ile Thr Tyr Thr Pro Glu Asp Lys Val Thr Arg Ala Cys Lys Glu
        35                  40                  45              
Glu Gln Ile Glu Ala Leu Lys Glu Glu Val Arg Arg Met Ile Leu Ala
    50                  55                  60                  
Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg Leu Ile Asp Glu Val Gln
65                  70                  75                  80  
Arg Leu Gly Val Ala Tyr His Phe Glu Lys Glu Ile Glu Asp Met Leu
                85                  90                  95      
Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe Glu Ala His Glu Tyr Asn
            100                 105                 110         
Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg Gln Gln Gly
        115                 120                 125             
Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp Asp Glu Gly
    130                 135                 140                 
Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met Leu Ser Leu
145                 150                 155                 160 
Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile Leu Asp Glu
                165                 170                 175     
Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Ala Ala Pro His Leu
            180                 185                 190         
Lys Ser Pro Leu Ala Glu Gln Ile Asn His Ala Leu Tyr Arg Pro Leu
        195                 200                 205             
Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr Ile Met Ser Val Tyr
    210                 215                 220                 
Gln Asp Glu Ala Phe His Asn Lys Thr Leu Leu Asn Phe Ala Lys Leu
225                 230                 235                 240 
Asp Phe Asn Ile Leu Leu Asp Leu His Lys Glu Glu Leu Asn Glu Leu
                245                 250                 255     
Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr Thr Lys Leu Pro Tyr Ala
            260                 265                 270         
Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp Asp Leu Gly Thr Tyr Phe
        275                 280                 285             
Glu Ser Gln Tyr Ala Phe Gly Arg Lys Ile Met Thr Lys Leu Asn Tyr
    290                 295                 300                 
Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp Ala Tyr Gly Thr Leu Glu
305                 310                 315                 320 
Glu Cys Thr Met Phe Ser Glu Ala Val Ala Arg Trp Asn Ile Glu Ala
                325                 330                 335     
Val Asp Met Leu Pro Asp Tyr Met Arg Ile Ile Tyr Arg Thr Leu Leu
            340                 345                 350         
Asp Thr Phe Asn Glu Ile Glu Glu Asp Met Ala Lys Gln Arg Arg Ser
        355                 360                 365             
His Cys Val Arg Tyr Ala Lys Glu Glu Ile Gln Lys Val Ile Gly Ala
    370                 375                 380                 
Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu Gly Tyr Val Pro Thr Ile
385                 390                 395                 400 
Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser Cys Ala Tyr Arg Phe Val
                405                 410                 415     
Ile Thr Asn Ser Phe Leu Gly Met Gly Asp Phe Ala Thr Lys Glu Val
            420                 425                 430         
Phe Glu Trp Ile Ser Gly Asn Pro Lys Val Val Lys Ser Ala Ser Val
        435                 440                 445             
Ile Cys Arg Leu Met Asp Asp Met Gln Gly His Glu Phe Glu Gln Lys
    450                 455                 460                 
Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr Thr Lys Gln His Gly
465                 470                 475                 480 
Val Ser Lys Glu Glu Ala Ile Lys Met Phe Glu Glu Asp Val Ala Asn
                485                 490                 495     
Ala Trp Lys Asp Ile Asn Glu Glu Leu Met Met Lys Pro Pro Val Val
            500                 505                 510         
Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu Ala Arg Ala Ile Asp
        515                 520                 525             
Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His Ser Tyr Leu Ile Lys
    530                 535                 540                 
Glu Gln Ile Ala Ser Val Leu Gly Asp His Val Pro Phe
545                 550                 555         


<210> 888
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V278

<400> 888
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Val Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Ser Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 889
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V279

<400> 889
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Ala Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Ser Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 890
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V280

<400> 890
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Val Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Leu Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 891
<211> 1674
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V277

<400> 891
atgtctactc aagtctcagc atcttctcta gcccagattc cccaacccaa aaatcgtcct 60
gtggcaaact ttcaccccaa catttggggt gaccaattta tcacctacac tcctgaagac 120
aaggttactc gtgcctgcaa agaggagcag attgaagctt tgaaggaaga agttagaaga 180
atgattttag caaccggaag gaaaccaatt caaaaattga gattgattga tgaagttcaa 240
agattgggtg ttgcttacca ttttgaaaaa gaaattgaag atatgttgga tcacatttac 300
agagctgatc cttattttga ggctcatgaa tacaatgatt tgcatactgt ttctttgcat 360
ttcagattgt tgagacaaca aggtattaag atttcttgtg atgttttcga acaatttaag 420
gatgatgaag gtagattcaa aagttctttg attaatgatg ttcaaggcat gttgtctttg 480
tatgaagctg cttatatggc tgttagaggt gaacatattt tggatgaagc tattgcattt 540
actactactc atttgcaatc tgcagctcca catttgaagt cacctttggc tgaacaaatt 600
aaccatgctt tgtatagacc attgagaaaa actttgccaa gattggaagc aagatacatt 660
atgtcagtct accaagatga agctttccat aacaagactt tgttaaattt cgctaagttg 720
gatttcaata ttttgttgga tttgcataaa gaagaattga acgaattgac taaatggtgg 780
caagatttgg attttactac taaattgcca tatgctagag atagattggt tgaactgtac 840
ttttgggatt tggggactta ttttgaatca caatacgctt ttggtagaaa aatcatgact 900
aaattgaact acattttgtc cattattgat gatacctacg atgcttacgg tactttggaa 960
gaatgcacga tgttcagtga agctgttgct cgttggaaca ttgaagctgt tgatatgttg 1020
ccagattata tgcgaattat ctacagaact ttgttggata cattcaacga aatagaagag 1080
gatatggcta aacaacggag atctcattgt gtaagatacg ctaaagaaga aattcaaaag 1140
gttattggtg cttattacgt tcaagctaag tggttttctg aaggttatgt ccctactatt 1200
gaagaataca tgccaattgc tttgacttct tgcgcttaca gatttgttat taccaattct 1260
tttttgggta tgggtgattt cgctacaaag gaagtattcg aatggatttc tggtaatcca 1320
aaagttgtta aatctgcttc tgttatttgt agattgatgg acgatatgca aggacacgaa 1380
tttgaacaaa aaagaggtca cgttgcatct gcaattgaat gctatactaa acaacatggt 1440
gtttccaagg aagaggctat caagatgttc gaggaagatg ttgctaacgc ttggaaggat 1500
atcaatgaag aattaatgat gaaaccacca gttgttgcta gaccattgtt aggtactatt 1560
ttgaatttgg ctagagctat cgattttatc tataaagaag atgacggtta cactcattct 1620
tatttgatta aggaacaaat cgcatctgtt ttgggtgatc atgttccatt ttaa       1674

<210> 892
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V278

<400> 892
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcacgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagcag cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgaggaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgtttctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagatc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 893
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V279

<400> 893
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tgctactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc agttcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 894
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V280

<400> 894
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccagtt 180
caaaaattga gattgattga tgaacttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcataccgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 895
<211> 547
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS mutant V281

<400> 895
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Pro Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Tyr Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Val Tyr Gln Asp Glu Ala Phe His Asn Lys Thr Leu
    210                 215                 220                 
Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His Lys
225                 230                 235                 240 
Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr
                245                 250                 255     
Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp
            260                 265                 270         
Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys Ile
        275                 280                 285             
Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp
    290                 295                 300                 
Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val Ala
305                 310                 315                 320 
Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg Ile
                325                 330                 335     
Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp Met
            340                 345                 350         
Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu Ile
        355                 360                 365             
Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu
    370                 375                 380                 
Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser
385                 390                 395                 400 
Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly Asp
                405                 410                 415     
Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys Val
            420                 425                 430         
Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln Gly
        435                 440                 445             
His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys
    450                 455                 460                 
Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe
465                 470                 475                 480 
Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met
                485                 490                 495     
Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn
            500                 505                 510         
Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr
        515                 520                 525             
His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His
    530                 535                 540                 
Val Pro Phe
545         


<210> 896
<211> 1644
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS mutant V281

<400> 896
atgtcatctg gtgaaacttt tagaccaact gctgatttcc atccatcttt gtggaaaaat 60
cattttttgc caggtgcatc agattttaag actgttgatc atacagctac atatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcagtct accaagatga agctttccat 660
aacaagactt tgttaaattt cgctaagttg gatttcaata ttttgttgga tttgcataaa 720
gaagaattga acgaattgac taaatggtgg caagatttgg attttactac taaattgcca 780
tatgctagag atagattggt tgaattgtac ttttgggatt tggggactta ttttgaatca 840
caatacgctt ttggtagaaa aatcatgact aaattgaact acattttgtc cattattgat 900
gatacctacg atgcttacgg tactttggaa gaatgcacga tgttcagtga agctgttgct 960
cgttggaaca ttgaagctgt tgatatgttg ccagattata tgcgaattat ctacagaact 1020
ttgttggata cattcaacga aatagaagag gatatggcta aacaacggag atctcattgt 1080
gtaagatacg ctaaagaaga aattcaaaag gttattggtg cttattacgt tcaagctaag 1140
tggttttctg aaggttatgt ccctactatt gaagaataca tgccaattgc tttgacttct 1200
tgcgcttaca gatttgttat taccaattct tttttgggta tgggtgattt cgctacaaag 1260
gaagtattcg aatggatttc tggtaatcca aaagttgtta aatctgcttc tgttatttgt 1320
agattgatgg acgatatgca aggacacgaa tttgaacaaa aaagaggtca cgttgcatct 1380
gcaattgaat gctatactaa acaacatggt gtttccaagg aagaggctat caagatgttc 1440
gaggaagatg ttgctaacgc ttggaaggat atcaatgaag aattaatgat gaaaccacca 1500
gttgttgcta gaccattgtt aggtactatt ttgaatttgg ctagagctat cgattttatc 1560
tataaagaag atgacggtta cactcattct tatttgatta aggaacaaat agcatctgtt 1620
ttgggtgatc atgttccatt ttaa                                        1644

<210> 897
<211> 56
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-73.39

<400> 897
aggtagatct cwttgtgtaa gatacgctaa agaagaaatt camaaggtta ttggtg     56

<210> 898
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-71.41

<400> 898
gctcgttgga acattgaagc tgttgacatg                                  30

<210> 899
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-71.42

<400> 899
catgtcaaca gcttcaatgt tccaacgagc                                  30

<210> 900
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-108.1

<220> 
<221> variation      
<222> (16)...(33)
<223> n = a or c or t or g

<400> 900
gttagaagaa tgattnnnnn nnnnnnnnnn nnnccaattc aaaaattg              48

<210> 901
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-108.2

<220> 
<221> variation      
<222> (16)...(33)
<223> n = a or c or t or g

<400> 901
caatttttga attggnnnnn nnnnnnnnnn nnnaatcatt cttctaac              48

<210> 902
<211> 73
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-140.1

<220> 
<221> variation      
<222> (22)...(51)
<223> n = a or c or t or g

<400> 902
gaagcaagat acattatgtc annnnnnnnn nnnnnnnnnn nnnnnnnnnn naacaagact 60
ttgttaaatt tcg                                                    73

<210> 903
<211> 73
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-140.2

<220> 
<221> variation      
<222> (23)...(52)
<223> n = a or c or t or g

<400> 903
cgaaatttaa caaagtcttg ttnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntgacataa 60
tgtatcttgc ttc                                                    73

<210> 904
<211> 59
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo revAA2-7rnd

<220> 
<221> variation      
<222> (20)...(27)
<223> n = a or c or t or g

<400> 904
gaaaatcagc agttggtctn nnnnnnnnnn nnnnnnncat ttttttaaat ggtaccgag  59

<210> 905
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.13

<400> 905
cgccccgtcg ccgacttctc cccatctttg tggaaaaatc                       40

<210> 906
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.14

<400> 906
gatttttcca caaagatggg gagaagtcgg cgacggggcg                       40

<210> 907
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.15

<400> 907
cgtcctgtgg caaactttca cccatctttg tggaaaaatc                       40

<210> 908
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.16

<400> 908
gatttttcca caaagatggg tgaaagtttg ccacaggacg                       40

<210> 909
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.17

<400> 909
cgccctgttg cagatttttc tccatctttg tggaaaaatc                       40

<210> 910
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.18

<400> 910
gatttttcca caaagatgga gaaaaatctg caacagggcg                       40

<210> 911
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.25

<400> 911
gaaaagtatg ctcaagagat tgaagctttg aaggaagaag                       40

<210> 912
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.26

<400> 912
cttcttcctt caaagcttca atctcttgag catacttttc                       40

<210> 913
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.27

<400> 913
gcctgcaaag aggagcagat tgaagctttg aaggaagaag                       40

<210> 914
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.28

<400> 914
cttcttcctt caaagcttca atctgctcct ctttgcaggc                       40

<210> 915
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.29

<400> 915
catttcagat tgttgagaca acaagggtac actatttcat gtg                   43

<210> 916
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.30

<400> 916
cacatgaaat agtgtaccct tgttgtctca acaatctgaa atg                   43

<210> 917
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.31

<400> 917
catttcagat tgttgagaca acacggtttc aacatctctc                       40

<210> 918
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.32

<400> 918
gagagatgtt gaaaccgtgt tgtctcaaca atctgaaatg                       40

<210> 919
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.33

<400> 919
catttcagat tgttgagaca acatggttac aacgtctctc c                     41

<210> 920
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.34

<400> 920
ggagagacgt tgtaaccatg ttgtctcaac aatctgaaat g                     41

<210> 921
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.35

<400> 921
gacatcaggg gcctactgaa cttgtatgaa gctgcttata tg                    42

<210> 922
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.36

<400> 922
catataagca gcttcataca agttcagtag gcccctgatg tc                    42

<210> 923
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.37

<400> 923
gatgtcttag gattattaaa cttgtatgaa gctgcttata tg                    42

<210> 924
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.38

<400> 924
catataagca gcttcataca agtttaataa tcctaagaca tc                    42

<210> 925
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.39

<400> 925
gatgtaagag gcatgctagg cttgtatgaa gctgcttata tg                    42

<210> 926
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.40

<400> 926
catataagca gcttcataca agcctagcat gcctcttaca tc                    42

<210> 927
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 11-154.4

<400> 927
agccgacaac cttgattgga gact                                        24

<210> 928
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 11-154.3

<400> 928
aatgagcaac ggtatacggc                                             20

<210> 929
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-130.3

<400> 929
catttacaga gctgatcctt attttgaggc tcatgaatac aatgatttgc atactgtttc 60


<210> 930
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-130.4

<400> 930
aaataaggat cagctctgta aatgtgatcc aacatatctt caatttcttt ttcaaaatgg 60


<210> 931
<211> 86
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-141.7

<400> 931
gaaaaagaaa ttgaagatgc attacaacat atttgtaata gttttcatga ctgcaatgat 60
atggatggtg atttgcatac tgtttc                                      86

<210> 932
<211> 86
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-141.8

<400> 932
gaaacagtat gcaaatcacc atccatatca ttgcagtcat gaaaactatt acaaatatgt 60
tgtaatgcat cttcaatttc tttttc                                      86

<210> 933
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-134.9

<400> 933
tctgcagctc cacatttgaa gtcacctttg gctgaacaaa ttaac                 45

<210> 934
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-134.10

<400> 934
aggtgacttc aaatgtggag ctgcagattg caaatgagta gtag                  44

<210> 935
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-141.5

<400> 935
gcaagataca ttatgtcaat ctacgaagag gaggaattta agaacaagac tttgttaaat 60
ttc                                                               63

<210> 936
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-141.6

<400> 936
gaaatttaac aaagtcttgt tcttaaattc ctcctcttcg tagattgaca taatgtatct 60
tgc                                                               63

<210> 937
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.1

<400> 937
gcaagataca ttatgtcatc aatctatgac aaggaacaat cgaagaacaa gactttgtta 60
aatttc                                                            66

<210> 938
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.2

<400> 938
gaaatttaac aaagtcttgt tcttcgattg ttccttgtca tagattgatg acataatgta 60
tcttgc                                                            66

<210> 939
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.3

<400> 939
gcaagataca ttatgtcagt ctaccaagat gaagctttcc ataacaagac tttgttaaat 60
ttc                                                               63

<210> 940
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligo 21-145.4

<400> 940
gaaatttaac aaagtcttgt tatggaaagc ttcatcttgg tagactgaca taatgtatct 60
tgc                                                               63

<210> 941
<211> 548
<212> PRT
<213> Nicotiana tabacum

<220> 
<223> 5-epi-aristolochene synthase

<400> 941
Met Ala Ser Ala Ala Val Ala Asn Tyr Glu Glu Glu Ile Val Arg Pro
 1               5                  10                  15      
Val Ala Asp Phe Ser Pro Ser Leu Trp Gly Asp Gln Phe Leu Ser Phe
            20                  25                  30          
Ser Ile Asp Asn Gln Val Ala Glu Lys Tyr Ala Gln Glu Ile Glu Ala
        35                  40                  45              
Leu Lys Glu Gln Thr Arg Ser Met Leu Leu Ala Thr Gly Arg Lys Leu
    50                  55                  60                  
Ala Asp Thr Leu Asn Leu Ile Asp Ile Ile Glu Arg Leu Gly Ile Ser
65                  70                  75                  80  
Tyr His Phe Glu Lys Glu Ile Asp Glu Ile Leu Asp Gln Ile Tyr Asn
                85                  90                  95      
Gln Asn Ser Asn Cys Asn Asp Leu Cys Thr Ser Ala Leu Gln Phe Arg
            100                 105                 110         
Leu Leu Arg Gln His Gly Phe Asn Ile Ser Pro Glu Ile Phe Ser Lys
        115                 120                 125             
Phe Gln Asp Glu Asn Gly Lys Phe Lys Glu Ser Leu Ala Ser Asp Val
    130                 135                 140                 
Leu Gly Leu Leu Asn Leu Tyr Glu Ala Ser His Val Arg Thr His Ala
145                 150                 155                 160 
Asp Asp Ile Leu Glu Asp Ala Leu Ala Phe Ser Thr Ile His Leu Glu
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Arg Glu Gln Val Thr His
            180                 185                 190         
Ala Leu Glu Gln Cys Leu His Lys Gly Val Pro Arg Val Glu Thr Arg
        195                 200                 205             
Phe Phe Ile Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Asn Val
    210                 215                 220                 
Leu Leu Arg Phe Ala Lys Leu Asp Phe Asn Leu Leu Gln Met Leu His
225                 230                 235                 240 
Lys Gln Glu Leu Ala Gln Val Ser Arg Trp Trp Lys Asp Leu Asp Phe
                245                 250                 255     
Val Thr Thr Leu Pro Tyr Ala Arg Asp Arg Val Val Glu Cys Tyr Phe
            260                 265                 270         
Trp Ala Leu Gly Val Tyr Phe Glu Pro Gln Tyr Ser Gln Ala Arg Val
        275                 280                 285             
Met Leu Val Lys Thr Ile Ser Met Ile Ser Ile Val Asp Asp Thr Phe
    290                 295                 300                 
Asp Ala Tyr Gly Thr Val Lys Glu Leu Glu Ala Tyr Thr Asp Ala Ile
305                 310                 315                 320 
Gln Arg Trp Asp Ile Asn Glu Ile Asp Arg Leu Pro Asp Tyr Met Lys
                325                 330                 335     
Ile Ser Tyr Lys Ala Ile Leu Asp Leu Tyr Lys Asp Tyr Glu Lys Glu
            340                 345                 350         
Leu Ser Ser Ala Gly Arg Ser His Ile Val Cys His Ala Ile Glu Arg
        355                 360                 365             
Met Lys Glu Val Val Arg Asn Tyr Asn Val Glu Ser Thr Trp Phe Ile
    370                 375                 380                 
Glu Gly Tyr Thr Pro Pro Val Ser Glu Tyr Leu Ser Asn Ala Leu Ala
385                 390                 395                 400 
Thr Thr Thr Tyr Tyr Tyr Leu Ala Thr Thr Ser Tyr Leu Gly Met Lys
                405                 410                 415     
Ser Ala Thr Glu Gln Asp Phe Glu Trp Leu Ser Lys Asn Pro Lys Ile
            420                 425                 430         
Leu Glu Ala Ser Val Ile Ile Cys Arg Val Ile Asp Asp Thr Ala Thr
        435                 440                 445             
Tyr Glu Val Glu Lys Ser Arg Gly Gln Ile Ala Thr Gly Ile Glu Cys
    450                 455                 460                 
Cys Met Arg Asp Tyr Gly Ile Ser Thr Lys Glu Ala Met Ala Lys Phe
465                 470                 475                 480 
Gln Asn Met Ala Glu Thr Ala Trp Lys Asp Ile Asn Glu Gly Leu Leu
                485                 490                 495     
Arg Pro Thr Pro Val Ser Thr Glu Phe Leu Thr Pro Ile Leu Asn Leu
            500                 505                 510         
Ala Arg Ile Val Glu Val Thr Tyr Ile His Asn Leu Asp Gly Tyr Thr
        515                 520                 525             
His Pro Glu Glu Val Leu Lys Pro His Ile Ile Asn Leu Leu Val Asp
    530                 535                 540                 
Ser Ile Lys Ile
545             


<210> 942
<211> 555
<212> PRT
<213> Hyoscyamus muticus

<220> 
<223> premnaspirodiene synthase

<400> 942
Met Ala Pro Ala Ile Val Met Ser Asn Tyr Glu Glu Glu Glu Ile Val
 1               5                  10                  15      
Arg Pro Val Ala Asp Phe Ser Pro Ser Leu Trp Gly Asp His Phe His
            20                  25                  30          
Ser Phe Ser Val Asp Asn Gln Val Ala Glu Lys Tyr Ala Gln Glu Ile
        35                  40                  45              
Glu Thr Leu Lys Glu Gln Thr Ser Thr Met Leu Ser Ala Ala Cys Gly
    50                  55                  60                  
Thr Thr Leu Thr Glu Lys Leu Asn Leu Ile Asp Ile Ile Glu Arg Leu
65                  70                  75                  80  
Gly Ile Ala Tyr His Phe Glu Lys Gln Ile Glu Asp Met Leu Asp His
                85                  90                  95      
Ile Tyr Arg Ala Asp Pro Tyr Phe Glu Ala His Glu Tyr Asn Asp Leu
            100                 105                 110         
Asn Thr Ser Ser Val Gln Phe Arg Leu Leu Arg Gln His Gly Tyr Asn
        115                 120                 125             
Val Ser Pro Asn Ile Phe Ser Arg Phe Gln Asp Ala Asn Gly Lys Phe
    130                 135                 140                 
Lys Glu Ser Leu Arg Ser Asp Ile Arg Gly Leu Leu Asn Leu Tyr Glu
145                 150                 155                 160 
Ala Ser His Val Arg Thr His Lys Glu Asp Ile Leu Glu Glu Ala Leu
                165                 170                 175     
Val Phe Ser Val Gly His Leu Glu Ser Ala Ala Pro His Leu Lys Ser
            180                 185                 190         
Pro Leu Ser Lys Gln Val Thr His Ala Leu Glu Gln Ser Leu His Lys
        195                 200                 205             
Ser Ile Pro Arg Val Glu Ile Arg Tyr Phe Ile Ser Ile Tyr Glu Glu
    210                 215                 220                 
Glu Glu Phe Lys Asn Asp Leu Leu Leu Arg Phe Ala Lys Leu Asp Tyr
225                 230                 235                 240 
Asn Leu Leu Gln Met Leu His Lys His Glu Leu Ser Glu Val Ser Arg
                245                 250                 255     
Trp Trp Lys Asp Leu Asp Phe Val Thr Thr Leu Pro Tyr Ala Arg Asp
            260                 265                 270         
Arg Ala Val Glu Cys Tyr Phe Trp Thr Met Gly Val Tyr Ala Glu Pro
        275                 280                 285             
Gln Tyr Ser Gln Ala Arg Val Met Leu Ala Lys Thr Ile Ala Met Ile
    290                 295                 300                 
Ser Ile Val Asp Asp Thr Phe Asp Ala Tyr Gly Ile Val Lys Glu Leu
305                 310                 315                 320 
Glu Val Tyr Thr Asp Ala Ile Gln Arg Trp Asp Ile Ser Gln Ile Asp
                325                 330                 335     
Arg Leu Pro Glu Tyr Met Lys Ile Ser Tyr Lys Ala Leu Leu Asp Leu
            340                 345                 350         
Tyr Asp Asp Tyr Glu Lys Glu Leu Ser Lys Asp Gly Arg Ser Asp Val
        355                 360                 365             
Val His Tyr Ala Lys Glu Arg Met Lys Glu Ile Val Gly Asn Tyr Phe
    370                 375                 380                 
Ile Glu Gly Lys Trp Phe Ile Glu Gly Tyr Met Pro Ser Val Ser Glu
385                 390                 395                 400 
Tyr Leu Ser Asn Ala Leu Ala Thr Ser Thr Tyr Tyr Leu Leu Thr Thr
                405                 410                 415     
Thr Ser Tyr Leu Gly Met Lys Ser Ala Thr Lys Glu His Phe Glu Trp
            420                 425                 430         
Leu Ala Thr Asn Pro Lys Ile Leu Glu Ala Asn Ala Thr Leu Cys Arg
        435                 440                 445             
Val Val Asp Asp Ile Ala Thr Tyr Glu Val Glu Lys Gly Arg Gly Gln
    450                 455                 460                 
Ile Ala Thr Gly Ile Glu Cys Tyr Met Arg Asp Tyr Gly Val Ser Thr
465                 470                 475                 480 
Glu Val Ala Met Glu Lys Phe Gln Glu Met Ala Asp Ile Ala Trp Lys
                485                 490                 495     
Asp Val Asn Glu Glu Ile Leu Arg Pro Thr Pro Val Ser Ser Glu Ile
            500                 505                 510         
Leu Thr Arg Ile Leu Asn Leu Ala Arg Ile Ile Asp Val Thr Tyr Lys
        515                 520                 525             
His Asn Gln Asp Gly Tyr Thr His Pro Glu Lys Val Leu Lys Pro His
    530                 535                 540                 
Ile Ile Ala Leu Val Val Asp Ser Ile Asp Ile
545                 550                 555 


<210> 943
<211> 1668
<212> DNA
<213> Hyoscyamus muticus

<220> 
<223> premnaspirodiene synthase

<400> 943
atggccccag ctatagtgat gagtaactac gaagaggagg agattgttcg ccctgttgca 60
gatttttctc caagtctttg gggtgatcat ttccattcat tctcagttga caatcaggtt 120
gcggaaaagt atgctcaaga gattgaaact ttgaaggaac aaacaagtac tatgttgtct 180
gctgcttgtg gaacaacatt gactgagaaa ttgaatttga tagatattat tgagcgcctt 240
ggaatagctt atcatttcga gaaacaaata gaagatatgt tggatcacat ttacagagct 300
gatccttatt ttgaggctca tgaatacaat gatttaaaca cttcatccgt tcaatttcga 360
ctactcagac aacatggtta caacgtctct ccaaatatat ttagcagatt ccaagatgca 420
aatggcaaat tcaaggagtc tcttagaagc gacatcaggg gcctactgaa cttatacgaa 480
gcttcacatg taaggactca taaagaggat attttggaag aagcacttgt tttttctgtt 540
ggtcatcttg aatctgcagc tccacatttg aagtcacctc tgagtaagca agtgacacat 600
gccctcgaac aatctctcca taagagcatt ccaagagtcg agatacggta cttcatctcc 660
atctacgaag aggaggaatt taagaatgat ttgttgcttc gatttgctaa attggattac 720
aacttacttc agatgttgca caagcatgaa ctcagtgaag tatcaaggtg gtggaaagat 780
ttggatttcg tgacaacact tccatatgct agggacagag cagttgagtg ctacttttgg 840
acgatggggg tgtatgctga acctcaatac tcccaggctc gtgtcatgct tgctaagact 900
atagcaatga tttccatagt agatgacaca ttcgatgctt atggcatcgt aaaagaactt 960
gaagtctaca cagatgccat acagaggtgg gatattagtc aaattgatcg actcccggaa 1020
tatatgaaaa tcagttataa ggctcttttg gatctctatg acgattatga aaaggagttg 1080
tcaaaggatg gtagatccga tgttgtccac tatgcaaaag aaagaatgaa ggagattgtg 1140
ggaaactatt ttattgaagg aaaatggttt attgagggat atatgccatc tgtttccgag 1200
taccttagca atgcactagc tactagcaca tattacttgc taactacgac atcctacttg 1260
ggaatgaaat cagcaaccaa ggaacatttt gaatggttgg ctacgaaccc taaaattctg 1320
gaagctaatg ctacattatg ccgagttgtt gatgacatag ccacgtatga ggttgagaag 1380
ggtaggggtc aaattgcaac aggaattgag tgttatatga gggattacgg tgtatccaca 1440
gaagtagcaa tggagaaatt ccaagaaatg gctgacatag catggaagga tgtaaatgaa 1500
gaaattcttc gaccaacacc tgtctcttca gaaattctta ctcgtattct caacctggct 1560
cgaattatag atgtcactta caagcataat caagatggat acactcatcc tgaaaaagta 1620
ctaaaacctc acatcatcgc cttggtggtg gattctattg atatttga              1668

<210> 944
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V287

<400> 944
Met Lys Glu Cys Thr Met Leu Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 945
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V287

<400> 945
atgaaagaat gtacgatgtt aagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattc tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgagatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taagcaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 946
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V288

<400> 946
Met Lys Glu Cys Thr Met Leu Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Ala Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Ala Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 947
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V288

<400> 947
atgaaagaat gtacgatgtt aagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgcg cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgctatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taagcaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 948
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V289

<400> 948
Met Cys Met Thr Gly Glu Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 949
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V289

<400> 949
atgtgcatga caggtgaatc gagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc actgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcgtcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 950
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V290

<400> 950
Met Cys Met Thr Gly Glu Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 951
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V290

<400> 951
atgtgcatga caggtgaatc gagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgcgtaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 952
<211> 547
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V292

<400> 952
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Val Tyr Gln Asp Glu Ala Phe His Asn Lys Thr Leu
    210                 215                 220                 
Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His Lys
225                 230                 235                 240 
Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr
                245                 250                 255     
Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp
            260                 265                 270         
Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys Ile
        275                 280                 285             
Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp
    290                 295                 300                 
Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val Ala
305                 310                 315                 320 
Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg Ile
                325                 330                 335     
Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp Met
            340                 345                 350         
Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu Ile
        355                 360                 365             
Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu
    370                 375                 380                 
Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser
385                 390                 395                 400 
Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly Asp
                405                 410                 415     
Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys Val
            420                 425                 430         
Val Lys Ser Ala Ser Leu Ile Cys Arg Leu Met Asp Asp Met Gln Gly
        435                 440                 445             
His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu Cys
    450                 455                 460                 
Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met Phe
465                 470                 475                 480 
Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu Met
                485                 490                 495     
Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn
            500                 505                 510         
Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr
        515                 520                 525             
His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp His
    530                 535                 540                 
Val Pro Phe
545         


<210> 953
<211> 1644
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V292

<400> 953
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctccg 540
catttgaagt cacctttggc tgaacaaatt aaccatgcat tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcagtct accaagatga agctttccat 660
aacaagactt tgttaaattt cgctaagttg gatttcaata ttttgttgga tttgcataaa 720
gaagaattga acgaattgac taaatggtgg caagatttgg attttactac taaattgcca 780
tatgctagag atagattggt tgaattgtac ttttgggatt tggggactta ttttgaatca 840
caatacgctt ttggtagaaa aatcatgact aaattgaact acattttgtc cattattgat 900
gatacctacg atgcttacgg tactttggaa gaatgcacga tgttcagtga agctgttgct 960
cgttggaaca ttgaagctgt tgatatgttg ccagattata tgcgaattat ctacagaact 1020
ttgttggata cattcaacga aatagaagag gatatggcta aacaacggag atctcattgt 1080
gtaagatacg ctaaagaaga aattcaaaag gttattggtg cttattacgt tcaagctaag 1140
tggttttctg aaggttatgt ccctactatt gaagaataca tgccaattgc tttgacttct 1200
tgcgcttaca gatttgttat taccaattct tttttgggta tgggtgattt cgctacaaag 1260
gaagtattcg aatggatttc tggtaatcca aaagttgtta aatctgcttc tcttatttgt 1320
agattgatgg acgatatgca aggacacgaa tttgaacaaa aaagaggtca cgttgcatct 1380
gcaattgaat gctatactaa acaacatggt gtttccaagg aagaggctat caagatgttc 1440
gaggaagatg ttgctaacgc ttggaaggat atcaatgaag aattaatgat gaaaccacca 1500
gttgttgcta gaccattgtt aggtactatt ttgaatttgg ctagagctat cgattttatc 1560
tataaagaag atgacggtta cactcattct tatttgatta aggaacaaat agcatctgtt 1620
ttgggtgatc atgttccatt ttaa                                        1644

<210> 954
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V293

<400> 954
Met Ala Gly Glu Ala Thr Gly Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Glu Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 955
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V293

<400> 955
atggctggag aggcgacagg aagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaggc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatggaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 956
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V294

<400> 956
Met Cys Met Thr Gly Glu Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 957
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V294

<400> 957
atgtgcatga caggtgaatc gagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc cttgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcagggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 958
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V295

<400> 958
Met Lys Glu Cys Thr Met Leu Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 959
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V295

<400> 959
atgaaagaat gtacgatgtt aagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc cttgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcac 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taagcaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 960
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V296

<400> 960
Met Lys Glu Cys Thr Met Leu Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 961
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V296

<400> 961
atgaaagaat gtacgatgtt aagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taagcaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 962
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V297

<400> 962
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Tyr Thr Ile Ser Cys Asp Ile Phe Asn Lys
        115                 120                 125             
Phe Thr Asp Glu Arg Gly Arg Phe Lys Glu Ala Leu Ile Ser Asp Val
    130                 135                 140                 
Arg Gly Met Leu Gly Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 963
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V297

<400> 963
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca agggtacact 360
atttcatgtg atatattcaa caagtttacg gatgaacgag gtagattcaa ggaagctttg 420
atcagcgatg taagaggcat gctaggcttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 964
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V298

<400> 964
Met Lys Glu Cys Thr Met Leu Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 965
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V298

<400> 965
atgaaagaat gtacgatgtt aagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
accttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg ccacgttgca 1380
tctgcaattg aatgctatac taagcaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 966
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V299

<400> 966
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Thr Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 967
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V299

<400> 967
atgtcctctg gtgaaacttt tagaccaact actgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg tagcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 968
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V300

<400> 968
Thr Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala His Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Arg Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Gln Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 969
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V300

<400> 969
acgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg ctcatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
catcgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactcaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 970
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V301

<400> 970
Met Cys Met Thr Gly Glu Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 971
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V301

<400> 971
atgtgcatga caggtgaatc gagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc gttgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 972
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V302

<400> 972
Met Cys Met Thr Gly Glu Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 973
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V302

<400> 973
atgtgcatga caggtgaatc gagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgcggaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 974
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V303

<400> 974
Met Lys Glu Cys Thr Met Leu Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Gln Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 975
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V303

<400> 975
atgaaagaat gtacgatgtt aagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
caattgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgaaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taagcaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 976
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V304

<400> 976
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Leu Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 977
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V304

<400> 977
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gtacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgctagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 978
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V305
      

<400> 978
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Asp Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Leu Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 979
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V305
      

<400> 979
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgatgc tattgcattt actactactc atttgcaatc tgcagctcca 540
catctgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gtacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgctagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 980
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V306
      

<400> 980
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Thr Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Leu Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 981
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V306
      

<400> 981
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt acgtctagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tctctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ctaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcctatt tgattaagga acaaatagca 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 982
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V307
      

<400> 982
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 983
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V307
      

<400> 983
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagcagatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcagggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaatgcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cggttacact cattcttatt tgattaagga acaaatagcg 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 984
<211> 549
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V308
      

<400> 984
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asp His Phe Ser Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Glu
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn Lys
    210                 215                 220                 
Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu
225                 230                 235                 240 
His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp
                245                 250                 255     
Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr
            260                 265                 270         
Phe Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg
        275                 280                 285             
Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr
    290                 295                 300                 
Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala
305                 310                 315                 320 
Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met
                325                 330                 335     
Arg Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu Glu
            340                 345                 350         
Asp Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu
        355                 360                 365             
Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe
    370                 375                 380                 
Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu
385                 390                 395                 400 
Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met
                405                 410                 415     
Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro
            420                 425                 430         
Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met
        435                 440                 445             
Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile
    450                 455                 460                 
Glu Ser Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys
465                 470                 475                 480 
Met Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu
                485                 490                 495     
Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile
            500                 505                 510         
Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly
        515                 520                 525             
Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Val Ser Val Leu Gly
    530                 535                 540                 
Asp His Val Pro Phe
545                 


<210> 985
<211> 1650
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V308
      

<400> 985
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggaaagac 60
catttttcgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaggttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttggaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcaagaa ttgattctac ttctgatgat 660
ttggttaaca agactttgtt aaatttcgct aagttggatt tcaatatttt gttggatttg 720
cataaagaag aattgaacga attgactaaa tggtggcaag atttggattt tactactaaa 780
ttgccatatg ctagagatag attggttgaa ttgtactttt gggatttggg gacttatttt 840
gaatcacaat acgcttttgg tagaaaaatc atgactaaat tgaactacat tttgtccatt 900
attgatgata cctacgatgc ttacggtact ttggaagaat gcacgatgtt cagtgaagct 960
gttgctcgtt ggaacattga agctgttgat atgttgccag attatatgcg aattatctac 1020
agaactttgt tggatacatt caacgaaata gaagaggata tggctaaaca acggagatct 1080
cattgtgtaa gatacgctaa agaagaaatt caaaaggtta ttggtgctta ttacgttcaa 1140
gctaagtggt tttctgaagg ttatgtccct actattgaag aatacatgcc aattgctttg 1200
acttcttgcg cttacagatt tgttattacc aattcttttt tgggtatggg tgatttcgct 1260
acaaaggaag tattcgaatg gatttctggt aatccaaaag ttgttaaatc tgcttctgtt 1320
atttgtagat tgatggacga tatgcaagga cacgaatttg aacaaaaaag aggtcacgtt 1380
gcatctgcaa ttgaaagcta tactaaacaa catggtgttt ccaaggaaga ggctatcaag 1440
atgttcgagg aagatgttgc taacgcttgg aaggatatca atgaagaatt aatgatgaaa 1500
ccaccagttg ttgctagacc attgttaggt actattttga atttggctag agctatcgat 1560
tttatctata aagaagatga cgggtacact cattcttatt tgattaagga acaaatagta 1620
tctgttttgg gtgatcatgt tccattttaa                                  1650

<210> 986
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V309
      

<400> 986
Met Cys Met Thr Gly Glu Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Ala Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 987
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V309
      

<400> 987
atgtgcatga caggtgaatc gagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa cgctatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 988
<211> 548
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V310
      

<400> 988
Met Cys Met Thr Gly Glu Ser Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Lys Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Leu Ala Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Met Leu Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe
                85                  90                  95      
Glu Ala His Glu Tyr Asn Asp Leu His Thr Val Ser Leu His Phe Arg
            100                 105                 110         
Leu Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln
        115                 120                 125             
Phe Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val
    130                 135                 140                 
Gln Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly
145                 150                 155                 160 
Glu His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln
                165                 170                 175     
Ser Ala Ala Pro His Leu Lys Ser Pro Leu Ala Glu Gln Ile Asn His
            180                 185                 190         
Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg
        195                 200                 205             
Tyr Ile Met Ser Ser Ile Tyr Asp Lys Glu Gln Ser Lys Asn Lys Thr
    210                 215                 220                 
Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp Leu His
225                 230                 235                 240 
Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu Asp Phe
                245                 250                 255     
Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu Tyr Phe
            260                 265                 270         
Trp Asp Leu Gly Thr Tyr Phe Glu Ser Gln Tyr Ala Phe Gly Arg Lys
        275                 280                 285             
Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp Thr Tyr
    290                 295                 300                 
Asp Ala Tyr Gly Thr Leu Glu Glu Cys Thr Met Phe Ser Glu Ala Val
305                 310                 315                 320 
Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr Met Arg
                325                 330                 335     
Ile Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Ser Ile Glu Glu Asp
            340                 345                 350         
Met Ala Lys Gln Arg Arg Ser His Cys Val Arg Tyr Ala Lys Glu Glu
        355                 360                 365             
Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp Phe Ser
    370                 375                 380                 
Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala Leu Thr
385                 390                 395                 400 
Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly Met Gly
                405                 410                 415     
Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn Pro Lys
            420                 425                 430         
Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp Met Gln
        435                 440                 445             
Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala Ile Glu
    450                 455                 460                 
Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile Lys Met
465                 470                 475                 480 
Phe Glu Glu Asp Val Ala Asn Ala Trp Lys Asp Ile Asn Glu Glu Leu
                485                 490                 495     
Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr Ile Leu
            500                 505                 510         
Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp Gly Tyr
        515                 520                 525             
Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu Gly Asp
    530                 535                 540                 
His Val Pro Phe
545             


<210> 989
<211> 1647
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V310
      

<400> 989
atgtgcatga caggtgaatc gagaccaact gctgattttc atccatcttt gtggaaaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattttag caaccggaag gaaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atatgttgga tcacatttac agagctgatc cttattttga ggctcatgaa 300
tacaatgatt tgcatactgt ttctttgcat ttcagattgt tgagacaaca aggtattaag 360
atttcttgtg atgttttcga acaatttaag gatgatgaag gtagattcaa aagttctttg 420
attaatgatg ttcaaggcat gttgtctttg tatgaagctg cttatatggc tgttagaggt 480
gaacatattt tggatgaagc tattgcattt actactactc atttgcaatc tgcagctcca 540
catttgaagt cacctttggc tgaacaaatt aaccatgctt tgtatagacc attgagaaaa 600
actttgccaa gattggaagc aagatacatt atgtcatcaa tctatgacaa ggaacaatcg 660
aagaacaaga ctttgttaaa tttcgctaag ttggatttca atattttgtt ggatttgcat 720
aaagaagaat tgaacgaatt gactaaatgg tggcaagatt tggattttac tactaaattg 780
ccatatgcta gagatagatt ggttgaattg tacttttggg atttggggac ttattttgaa 840
tcacaatacg cttttggtag aaaaatcatg actaaattga actacatttt gtccattatt 900
gatgatacct acgatgctta cggtactttg gaagaatgca cgatgttcag tgaagctgtt 960
gctcgttgga acattgaagc tgttgatatg ttgccagatt atatgcgaat tatctacaga 1020
actttgttgg atacattcaa ctcaatagaa gaggatatgg ctaaacaacg gagatctcat 1080
tgtgtaagat acgctaaaga agaaattcaa aaggttattg gtgcttatta cgttcaagct 1140
aagtggtttt ctgaaggtta tgtccctact attgaagaat acatgccaat tgctttgact 1200
tcttgcgctt acagatttgt tattaccaat tcttttttgg gtatgggtga tttcgctaca 1260
aaggaagtat tcgaatggat ttctggtaat ccaaaagttg ttaaatctgc ttctgttatt 1320
tgtagattga tggacgatat gcaaggacac gaatttgaac aaaaaagagg tcacgttgca 1380
tctgcaattg aatgctatac taaacaacat ggtgtttcca aggaagaggc tatcaagatg 1440
ttcgaggaag atgttgctaa cgcttggaag gatatcaatg aagaattaat gatgaaacca 1500
ccagttgttg ctagaccatt gttaggtact attttgaatt tggctagagc tatcgatttt 1560
atctataaag aagatgacgg ttacactcat tcttatttga ttaaggaaca aatagcatct 1620
gttttgggtg atcatgttcc attttaa                                     1647

<210> 990
<211> 550
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V311
      

<400> 990
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Ile Glu Asp Ala Ile Gln Gln Leu Cys Asn Ser Phe His Asp Cys
                85                  90                  95      
Asn Asp Met Asp Gly Asp Leu His Thr Val Ser Leu His Phe Arg Leu
            100                 105                 110         
Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe
        115                 120                 125             
Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln
    130                 135                 140                 
Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu
145                 150                 155                 160 
His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser
                165                 170                 175     
Leu Val Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn
            180                 185                 190         
His Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala
        195                 200                 205             
Arg Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn
    210                 215                 220                 
Lys Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp
225                 230                 235                 240 
Leu His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu
                245                 250                 255     
Asp Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu
            260                 265                 270         
Tyr Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly
        275                 280                 285             
Arg Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp
    290                 295                 300                 
Thr Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu
305                 310                 315                 320 
Ala Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr
                325                 330                 335     
Met Lys Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu
            340                 345                 350         
Glu Asp Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys
        355                 360                 365             
Glu Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp
    370                 375                 380                 
Phe Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala
385                 390                 395                 400 
Leu Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly
                405                 410                 415     
Met Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn
            420                 425                 430         
Pro Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp
        435                 440                 445             
Met Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala
    450                 455                 460                 
Ile Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile
465                 470                 475                 480 
Lys Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu
                485                 490                 495     
Glu Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr
            500                 505                 510         
Ile Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp
        515                 520                 525             
Gly Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu
    530                 535                 540                 
Gly Asp His Val Pro Phe
545                 550 


<210> 991
<211> 1653
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V311
      

<400> 991
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaaattgaag atgctattca acaattgtgt aatagttttc atgactgcaa tgatatggat 300
ggtgatttgc atactgtttc tttgcatttc agattgttga gacaacaagg tattaagatt 360
tcttgtgatg ttttcgaaca atttaaggat gatgaaggta gattcaaaag ttctttgatt 420
aatgatgttc aaggcatgtt gtctttgtat gaagctgctt atatggctgt tagaggtgaa 480
catattttgg atgaagctat tgcatttact actactcatt tgcaatcatt ggttgcacaa 540
gatcatgtta ctccaagatt ggctgaacaa attaaccatg ctttgtatag accattgaga 600
aaaactttgc caagattgga agcaagatac attatgtcaa gaattgattc tacttctgat 660
gatttggtta acaagacttt gttaaatttc gctaagttgg atttcaatat tttgttggat 720
ttgcataaag aagaattgaa cgaattgact aaatggtggc aagatttgga ttttactact 780
aaattgccat atgctagaga tagattggtt gaattgtact tttgggattt gggtacttat 840
tttgaaccac aatacgcttt tggtagaaaa atcatgacta aattgaacta cattttgtcc 900
attattgatg atacctacga tgcttacggt actttggaag aattgtcttt gttcaccgaa 960
gctgttgctc gttggaacat tgaagctgtt gacatgttgc cagattatat gaagttaatc 1020
tacagaactt tgttggatac attcaacgaa atagaagagg atatggctaa acaaggtaga 1080
tctcattgtg taagatacgc taaagaagaa attcaaaagg ttattggtgc ttattacgtt 1140
caagctaagt ggttttctga aggttatgtc cctactattg aagaatacat gccaattgct 1200
ttgacttctt gcgcttacag atttgttatt accaattctt ttttgggtat gggtgatttc 1260
gctacaaagg aagtattcga atggatttct ggtaatccaa aagttgttaa atctgcttct 1320
gttatttgta gattgatgga cgatatgcaa ggacacgaat ttgaacaaaa aagaggtcac 1380
gttgcatctg caattgaatg ctatactaaa caacatggtg tttccaagga agaggctatc 1440
aagatgttcg aggaagaggt tgctaacgct tggaaggata tcaatgaaga attaatgatg 1500
aaaccaccag ttgttgctag accattgtta ggtactattt tgaatttggc tagagctatc 1560
gattttatct ataaagaaga tgacggttac actcattctt atttgattaa ggaacaaata 1620
gcatctgttt tgggtgatca tgttccattt taa                              1653

<210> 992
<211> 550
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V312
      

<400> 992
Met Ser Ser Gly Glu Thr Phe Arg Pro Thr Ala Asp Phe His Pro Ser
 1               5                  10                  15      
Leu Trp Arg Asn His Phe Leu Gln Gly Ala Ser Asp Phe Lys Thr Val
            20                  25                  30          
Asp His Thr Ala Thr Asn Glu Arg His Glu Ala Leu Lys Glu Glu Val
        35                  40                  45              
Arg Arg Met Ile Thr Asp Ala Glu Asp Gln Pro Ile Gln Lys Leu Arg
    50                  55                  60                  
Leu Ile Asp Glu Val Gln Arg Leu Gly Val Ala Tyr His Phe Glu Lys
65                  70                  75                  80  
Glu Val Glu Asp Ala Ile Gln Gln Leu Cys Asn Ser Phe His Asp Cys
                85                  90                  95      
Asn Asp Met Asp Gly Asp Leu His Thr Val Ser Leu His Phe Arg Leu
            100                 105                 110         
Leu Arg Gln Gln Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe
        115                 120                 125             
Lys Asp Asp Glu Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln
    130                 135                 140                 
Gly Met Leu Ser Leu Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu
145                 150                 155                 160 
His Ile Leu Asp Glu Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser
                165                 170                 175     
Leu Val Ala Gln Asp His Val Thr Pro Arg Leu Ala Glu Gln Ile Asn
            180                 185                 190         
His Ala Leu Tyr Arg Pro Leu Arg Lys Thr Leu Pro Arg Leu Glu Ala
        195                 200                 205             
Arg Tyr Ile Met Ser Arg Ile Asp Ser Thr Ser Asp Asp Leu Val Asn
    210                 215                 220                 
Lys Thr Leu Leu Asn Phe Ala Lys Leu Asp Phe Asn Ile Leu Leu Asp
225                 230                 235                 240 
Leu His Lys Glu Glu Leu Asn Glu Leu Thr Lys Trp Trp Gln Asp Leu
                245                 250                 255     
Asp Phe Thr Thr Lys Leu Pro Tyr Ala Arg Asp Arg Leu Val Glu Leu
            260                 265                 270         
Tyr Phe Trp Asp Leu Gly Thr Tyr Phe Glu Pro Gln Tyr Ala Phe Gly
        275                 280                 285             
Arg Lys Ile Met Thr Lys Leu Asn Tyr Ile Leu Ser Ile Ile Asp Asp
    290                 295                 300                 
Thr Tyr Asp Ala Tyr Gly Thr Leu Glu Glu Leu Ser Leu Phe Thr Glu
305                 310                 315                 320 
Ala Val Ala Arg Trp Asn Ile Glu Ala Val Asp Met Leu Pro Asp Tyr
                325                 330                 335     
Met Lys Leu Ile Tyr Arg Thr Leu Leu Asp Thr Phe Asn Glu Ile Glu
            340                 345                 350         
Glu Asp Met Ala Lys Gln Gly Arg Ser His Cys Val Arg Tyr Ala Lys
        355                 360                 365             
Glu Glu Ile Gln Lys Val Ile Gly Ala Tyr Tyr Val Gln Ala Lys Trp
    370                 375                 380                 
Phe Ser Glu Gly Tyr Val Pro Thr Ile Glu Glu Tyr Met Pro Ile Ala
385                 390                 395                 400 
Ser Thr Ser Cys Ala Tyr Arg Phe Val Ile Thr Asn Ser Phe Leu Gly
                405                 410                 415     
Met Gly Asp Phe Ala Thr Lys Glu Val Phe Glu Trp Ile Ser Gly Asn
            420                 425                 430         
Pro Lys Val Val Lys Ser Ala Ser Val Ile Cys Arg Leu Met Asp Asp
        435                 440                 445             
Met Gln Gly His Glu Phe Glu Gln Lys Arg Gly His Val Ala Ser Ala
    450                 455                 460                 
Ile Glu Cys Tyr Thr Lys Gln His Gly Val Ser Lys Glu Glu Ala Ile
465                 470                 475                 480 
Lys Met Phe Glu Glu Glu Val Ala Asn Ala Trp Lys Asp Ile Asn Glu
                485                 490                 495     
Glu Leu Met Met Lys Pro Pro Val Val Ala Arg Pro Leu Leu Gly Thr
            500                 505                 510         
Ile Leu Asn Leu Ala Arg Ala Ile Asp Phe Ile Tyr Lys Glu Asp Asp
        515                 520                 525             
Gly Tyr Thr His Ser Tyr Leu Ile Lys Glu Gln Ile Ala Ser Val Leu
    530                 535                 540                 
Gly Asp His Val Pro Phe
545                 550 


<210> 993
<211> 1653
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V312
      

<400> 993
atgtcatctg gtgaaacttt tagaccaact gctgattttc atccatcttt gtggagaaat 60
cattttttgc aaggtgcatc agattttaag actgttgatc atacagctac aaatgaaaga 120
catgaagctt tgaaggaaga agttagaaga atgattactg atgcagaaga tcaaccaatt 180
caaaaattga gattgattga tgaagttcaa agattgggtg ttgcttacca ttttgaaaaa 240
gaagttgaag atgctattca acaattgtgt aatagttttc atgactgcaa tgatatggat 300
ggtgatttgc atactgtttc tttgcatttc agattgttga gacaacaagg tattaagatt 360
tcttgtgatg ttttcgaaca atttaaggat gatgaaggta gattcaaaag ttctttgatt 420
aatgatgttc aaggcatgtt gtctttgtat gaagctgctt atatggctgt tagaggtgaa 480
catattttgg atgaagctat tgcatttact actactcatt tgcaatcatt ggttgcacaa 540
gatcatgtta ctccaagatt ggctgaacaa attaaccatg ctttgtatag accattgaga 600
aaaactttgc caagattgga agcaagatac attatgtcaa gaattgattc tacttctgat 660
gatttggtta acaagacttt gttaaatttc gctaagttgg atttcaatat tttgttggat 720
ttgcataaag aagaattgaa cgaattgact aaatggtggc aagatttgga ttttactact 780
aaattgccat atgctagaga tagattggtt gaattgtact tttgggattt gggtacttat 840
tttgaaccac aatacgcttt tggtagaaaa atcatgacta aattgaacta cattttgtcc 900
attattgatg atacctacga tgcttacggt actttggaag aattgtcttt gttcaccgaa 960
gctgttgctc gttggaacat tgaagctgtt gacatgttgc cagattatat gaagttaatc 1020
tacagaactt tgttggatac attcaacgaa atagaagagg atatggctaa acaaggtaga 1080
tctcattgtg taagatacgc taaagaagaa attcaaaagg ttattggtgc ttattacgtt 1140
caagctaagt ggttttctga aggttatgtc cctactattg aagaatacat gccaattgct 1200
tcgacttctt gcgcttacag atttgttatt accaattctt ttttgggtat gggtgatttc 1260
gctacaaagg aagtattcga atggatttct ggtaatccaa aagttgttaa atctgcttct 1320
gttatttgta gattgatgga cgatatgcaa ggacacgaat ttgaacaaaa aagaggtcac 1380
gttgcatctg caattgaatg ctatactaaa caacatggtg tttccaagga agaggctatc 1440
aagatgttcg aggaagaggt tgctaacgct tggaaggata tcaatgaaga attaatgatg 1500
aaaccaccag ttgttgctag accattgtta ggtactattt tgaatttggc tagagctatc 1560
gattttatct ataaagaaga tgacggttac actcattctt atttgattaa ggaacaaata 1620
gcatctgttt tgggtgatca tgttccattt taa                              1653

<210> 994
<211> 556
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V313
      

<400> 994
Met Ser Thr Gln Val Ser Ala Ser Ser Leu Ala Gln Ile Pro Gln Pro
 1               5                  10                  15      
Lys Asn Arg Pro Val Ala Asn Phe His Pro Asn Ile Trp Gly Asp Gln
            20                  25                  30          
Phe Ile Thr Tyr Thr Pro Glu Asp Lys Val Thr Arg Ala Cys Lys Glu
        35                  40                  45              
Glu Gln Ile Glu Ala Leu Lys Glu Glu Ile Arg Arg Met Ile Leu Ala
    50                  55                  60                  
Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg Leu Ile Asp Glu Val Gln
65                  70                  75                  80  
Arg Leu Gly Val Ala Tyr His Phe Glu Lys Glu Ile Glu Asp Ala Leu
                85                  90                  95      
Gln His Ile Cys Asn Ser Phe His Asp Cys Asn Asp Met Asp Gly Asp
            100                 105                 110         
Leu Tyr Thr Val Ser Leu His Phe Arg Leu Leu Arg Gln Gln Gly Tyr
        115                 120                 125             
Thr Ile Ser Cys Asp Ile Phe Asn Lys Phe Thr Asp Glu Arg Gly Arg
    130                 135                 140                 
Phe Lys Glu Ala Leu Ile Ser Asp Val Arg Gly Met Leu Gly Leu Tyr
145                 150                 155                 160 
Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile Leu Asp Glu Ala
                165                 170                 175     
Ile Ala Phe Thr Thr Thr His Leu Gln Ser Ala Ala Pro His Leu Lys
            180                 185                 190         
Ser Pro Leu Ala Glu Gln Ile Asn His Ala Leu Tyr Arg Pro Leu Arg
        195                 200                 205             
Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr Ile Met Ser Val Tyr Gln
    210                 215                 220                 
Asp Glu Ala Phe His Asn Lys Thr Leu Leu Asn Phe Ala Lys Leu Asp
225                 230                 235                 240 
Phe Asn Ile Leu Leu Asp Leu His Lys Glu Glu Leu Asn Glu Leu Thr
                245                 250                 255     
Lys Trp Trp Gln Asp Leu Asp Phe Thr Thr Lys Leu Pro Tyr Ala Arg
            260                 265                 270         
Asp Arg Leu Val Glu Leu Tyr Phe Trp Asp Leu Gly Thr Tyr Phe Glu
        275                 280                 285             
Ser Gln Tyr Ala Phe Gly Arg Lys Ile Met Thr Lys Leu Asn Tyr Ile
    290                 295                 300                 
Leu Ser Ile Ile Asp Asp Thr Tyr Asp Ala Tyr Gly Thr Leu Glu Glu
305                 310                 315                 320 
Cys Thr Met Phe Ser Glu Ala Val Ala Arg Trp Asn Ile Glu Ala Val
                325                 330                 335     
Asp Met Leu Pro Asp Tyr Met Arg Ile Ile Tyr Arg Thr Leu Leu Asp
            340                 345                 350         
Thr Phe Asn Glu Ile Glu Glu Asp Met Ala Lys Gln Arg Arg Ser His
        355                 360                 365             
Cys Val Arg Tyr Ala Lys Glu Glu Ile Gln Lys Val Ile Gly Ala Tyr
    370                 375                 380                 
Tyr Val Gln Ala Lys Trp Phe Ser Glu Gly Tyr Val Pro Thr Ile Glu
385                 390                 395                 400 
Glu Tyr Met Pro Ile Ala Leu Thr Ser Cys Ala Tyr Arg Phe Val Ile
                405                 410                 415     
Thr Asn Ser Phe Leu Gly Met Gly Asp Phe Ala Thr Lys Glu Val Phe
            420                 425                 430         
Glu Trp Ile Ser Gly Asn Pro Lys Val Val Lys Ser Ala Ser Val Ile
        435                 440                 445             
Cys Arg Leu Met Asp Asp Met Gln Gly His Glu Phe Glu Gln Lys Arg
    450                 455                 460                 
Gly His Val Ala Ser Ala Ile Glu Cys Tyr Thr Lys Gln His Gly Val
465                 470                 475                 480 
Ser Lys Glu Glu Ala Ile Lys Met Phe Glu Glu Asp Val Ala Asn Ala
                485                 490                 495     
Trp Lys Asp Ile Asn Glu Glu Leu Met Met Lys Pro Pro Val Val Ala
            500                 505                 510         
Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu Ala Arg Ala Ile Asp Phe
        515                 520                 525             
Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His Ser Tyr Leu Ile Lys Glu
    530                 535                 540                 
Gln Ile Ala Ser Val Leu Gly Asp His Val Pro Phe
545                 550                 555     


<210> 995
<211> 1671
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V313
      

<400> 995
atgtctactc aagtctcagc atcttctcta gcccagattc cccaacccaa aaatcgtcct 60
gtggcaaact ttcaccccaa catttggggt gaccaattta tcacctacac tcctgaagac 120
aaggttactc gtgcctgcaa agaggagcag attgaagctt tgaaggaaga aattagaaga 180
atgattttag caaccggaag gaaaccaatt caaaaattga gattgattga tgaagttcaa 240
agattgggtg ttgcttacca ttttgaaaaa gaaattgaag atgcattaca acatatttgt 300
aatagttttc atgactgcaa tgatatggat ggtgatttgt atactgtttc tttgcatttc 360
agattgttga gacaacaagg gtacactatt tcatgtgata tattcaacaa gtttacggat 420
gaacgaggta gattcaagga agctttgatc agcgatgtaa gaggcatgct aggcttgtat 480
gaagctgctt atatggctgt tagaggtgaa catattttgg atgaagctat tgcatttact 540
actactcatt tgcaatctgc agctccacat ttgaagtcac ctttggctga acaaattaac 600
catgctttgt atagaccatt gagaaaaact ttgccaagat tggaagcaag atacattatg 660
tcagtctacc aagatgaagc tttccataac aagactttgt taaatttcgc taagttggat 720
ttcaatattt tgttggattt gcataaagaa gaattgaacg aattgactaa atggtggcaa 780
gatttggatt ttactactaa attgccatat gctagagata gattggttga actgtacttt 840
tgggatttgg ggacttattt tgaatcacaa tacgcttttg gtagaaaaat catgactaaa 900
ttgaactaca ttttgtccat tattgatgat acctacgatg cttacggtac tttggaagaa 960
tgcacgatgt tcagtgaagc tgttgctcgt tggaacattg aagctgttga tatgttgcca 1020
gattatatgc gaattatcta cagaactttg ttggatacat tcaacgaaat agaagaggat 1080
atggctaaac aacggagatc tcattgtgta agatacgcta aagaagaaat tcaaaaggtt 1140
attggtgctt attacgttca agctaagtgg ttttctgaag gttatgtccc tactattgaa 1200
gaatacatgc caattgcttt gacttcttgc gcttacagat ttgttattac caattctttt 1260
ttgggtatgg gtgatttcgc tacaaaggaa gtattcgaat ggatttctgg taatccaaaa 1320
gttgttaaat ctgcttctgt tatttgtaga ttgatggacg atatgcaagg acacgaattt 1380
gaacaaaaaa gaggtcacgt tgcatctgca attgaatgct atactaaaca acatggtgtt 1440
tccaaggaag aggctatcaa gatgttcgag gaagatgttg ctaacgcttg gaaggatatc 1500
aatgaagaat taatgatgaa accaccagtt gttgctagac cattgttagg tactattttg 1560
aatttggcta gagctatcga ttttatctat aaagaagatg acggttacac tcattcttat 1620
ttgattaagg aacaaatcgc atctgttttg ggtgatcatg ttccatttta a          1671

<210> 996
<211> 556
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V314
      

<400> 996
Met Ser Thr Gln Val Ser Ala Ser Ser Leu Ala Gln Ile Pro Gln Pro
 1               5                  10                  15      
Lys Asn Arg Pro Val Ala Asn Phe His Pro Asn Ile Trp Gly Asp Gln
            20                  25                  30          
Phe Ile Thr Tyr Thr Pro Glu Asp Lys Val Thr Arg Ala Cys Lys Glu
        35                  40                  45              
Glu Gln Ile Glu Ala Leu Lys Glu Glu Val Arg Arg Met Ile Leu Ala
    50                  55                  60                  
Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg Leu Ile Asp Glu Val Gln
65                  70                  75                  80  
Arg Leu Gly Val Ala Tyr His Phe Glu Lys Glu Ile Glu Asp Ala Leu
                85                  90                  95      
Gln His Ile Cys Asn Ser Phe His Asp Cys Asn Asp Met Asp Gly Asp
            100                 105                 110         
Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg Gln Gln Gly Ile
        115                 120                 125             
Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp Asp Glu Gly Arg
    130                 135                 140                 
Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met Leu Ser Leu Tyr
145                 150                 155                 160 
Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile Leu Asp Glu Ala
                165                 170                 175     
Ile Ala Phe Thr Thr Thr His Leu Gln Ser Ala Ala Pro His Leu Lys
            180                 185                 190         
Ser Pro Leu Ala Glu Gln Ile Asn His Ala Leu Tyr Arg Pro Leu Arg
        195                 200                 205             
Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr Ile Met Ser Val Tyr Gln
    210                 215                 220                 
Asp Glu Ala Phe His Asn Lys Thr Leu Leu Asn Phe Ala Lys Leu Asp
225                 230                 235                 240 
Phe Asn Ile Leu Leu Asp Leu His Lys Glu Glu Leu Asn Glu Leu Thr
                245                 250                 255     
Lys Trp Trp Gln Asp Leu Asp Phe Thr Thr Lys Leu Pro Tyr Ala Arg
            260                 265                 270         
Asp Arg Leu Val Glu Leu Tyr Phe Trp Asp Leu Gly Thr Tyr Phe Glu
        275                 280                 285             
Ser Gln Tyr Ala Phe Gly Arg Lys Ile Met Thr Lys Leu Asn Tyr Ile
    290                 295                 300                 
Leu Ser Ile Ile Asp Asp Thr Tyr Asp Ala Tyr Gly Thr Leu Glu Glu
305                 310                 315                 320 
Cys Thr Met Phe Ser Glu Ala Val Ala Arg Trp Asn Ile Glu Ala Val
                325                 330                 335     
Asp Met Leu Pro Asp Tyr Met Arg Ile Ile Tyr Arg Thr Leu Leu Asp
            340                 345                 350         
Thr Phe Asn Glu Ile Glu Glu Asp Met Ala Lys Gln Arg Arg Ser His
        355                 360                 365             
Cys Val Arg Tyr Ala Lys Glu Glu Ile Gln Lys Val Ile Gly Ala Tyr
    370                 375                 380                 
Tyr Val Gln Ala Lys Trp Phe Ser Glu Gly Tyr Val Pro Thr Ile Glu
385                 390                 395                 400 
Glu Tyr Met Pro Ile Ala Leu Thr Ser Cys Ala Tyr Arg Phe Val Ile
                405                 410                 415     
Thr Asn Ser Phe Leu Gly Met Gly Asp Phe Ala Thr Lys Glu Val Phe
            420                 425                 430         
Glu Trp Ile Ser Gly Asn Pro Lys Val Val Lys Ser Ala Ser Val Ile
        435                 440                 445             
Cys Arg Leu Met Asp Asp Met Gln Gly His Glu Phe Glu Gln Lys Arg
    450                 455                 460                 
Gly His Val Ala Ser Ala Ile Glu Cys Tyr Thr Lys Gln His Gly Val
465                 470                 475                 480 
Ser Lys Glu Glu Ala Ile Lys Met Phe Glu Glu Asp Val Ala Asn Ala
                485                 490                 495     
Trp Lys Asp Ile Asn Glu Glu Leu Met Met Lys Pro Pro Val Val Ala
            500                 505                 510         
Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu Ala Arg Ala Ile Asp Phe
        515                 520                 525             
Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His Ser Tyr Leu Ile Lys Glu
    530                 535                 540                 
Gln Ile Ala Ser Val Leu Gly Asp His Val Pro Phe
545                 550                 555     


<210> 997
<211> 1671
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V314
      

<400> 997
atgtctactc aagtctcagc atcttctcta gcccagattc cccaacccaa aaatcgtcct 60
gtggcaaact ttcaccccaa catttggggt gaccaattta tcacctacac tcctgaagac 120
aaggttactc gtgcctgcaa agaggagcag attgaagctt tgaaggaaga agttagaaga 180
atgattttag caaccggaag gaaaccaatt caaaaattga gattgattga tgaagttcaa 240
agattgggtg ttgcttacca ttttgaaaaa gaaattgaag atgcattaca acatatttgt 300
aatagttttc atgactgcaa tgatatggat ggtgatttgc atactgtttc tttgcatttc 360
agattgttga gacaacaagg tattaagatt tcttgtgatg ttttcgaaca atttaaggat 420
gatgaaggta gattcaaaag ttctttgatt aatgatgttc aaggcatgtt gtctttgtat 480
gaagctgctt atatggctgt tagaggtgaa catattttgg atgaagctat tgcatttact 540
actactcatt tgcaatctgc agctccacat ttgaagtcac ctttggctga acaaattaac 600
catgctttgt atagaccatt gagaaaaact ttgccaagat tggaagcaag atacattatg 660
tcagtctacc aagatgaagc tttccataac aagactttgt taaatttcgc taagttggat 720
ttcaatattt tgttggattt gcataaagaa gaattgaacg aattgactaa atggtggcaa 780
gatttggatt ttactactaa attgccatat gctagagata gattggttga actgtacttt 840
tgggatttgg ggacttattt tgaatcacaa tacgcttttg gtagaaaaat catgactaaa 900
ttgaactaca ttttgtccat tattgatgat acctacgatg cttacggtac tttggaagaa 960
tgcacgatgt tcagtgaagc tgttgctcgt tggaacattg aagctgttga tatgttgcca 1020
gattatatgc gaattatcta cagaactttg ttggatacat tcaacgaaat agaagaggat 1080
atggctaaac aacggagatc tcattgtgta agatacgcta aagaagaaat tcaaaaggtt 1140
attggtgctt attacgttca agctaagtgg ttttctgaag gttatgtccc tactattgaa 1200
gaatacatgc caattgcttt gacttcttgc gcttacagat ttgttattac caattctttt 1260
ttgggtatgg gtgatttcgc tacaaaggaa gtattcgaat ggatttctgg taatccaaaa 1320
gttgttaaat ctgcttctgt tatttgtaga ttgatggacg atatgcaagg acacgaattt 1380
gaacaaaaaa gaggtcacgt tgcatctgca attgaatgct atactaaaca acatggtgtt 1440
tccaaggaag aggctatcaa gatgttcgag gaagatgttg ctaacgcttg gaaggatatc 1500
aatgaagaat taatgatgaa accaccagtt gttgctagac cattgttagg tactattttg 1560
aatttggcta gagctatcga ttttatctat aaagaagatg acggttacac tcattcttat 1620
ttgattaagg aacaaatcgc atctgttttg ggtgatcatg ttccatttta a          1671

<210> 998
<211> 557
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS variant V315
      

<400> 998
Met Ser Thr Gln Val Ser Ala Ser Ser Leu Ala Gln Ile Pro Gln Pro
 1               5                  10                  15      
Lys Asn Arg Pro Val Ala Asn Phe His Pro Asn Ile Trp Gly Asp Gln
            20                  25                  30          
Phe Ile Thr Tyr Thr Pro Glu Asp Lys Val Thr Arg Ala Cys Lys Glu
        35                  40                  45              
Glu Gln Ile Glu Ala Leu Lys Glu Glu Val Arg Arg Met Ile Leu Ala
    50                  55                  60                  
Thr Gly Arg Lys Pro Ile Gln Lys Leu Arg Leu Ile Asp Glu Val Gln
65                  70                  75                  80  
Arg Leu Gly Val Ala Tyr His Phe Glu Lys Glu Ile Glu Asp Met Leu
                85                  90                  95      
Asp His Ile Tyr Arg Ala Asp Pro Tyr Phe Glu Ala His Glu Tyr Asn
            100                 105                 110         
Asp Leu His Thr Val Ser Leu His Phe Arg Leu Leu Arg Gln Gln Gly
        115                 120                 125             
Ile Lys Ile Ser Cys Asp Val Phe Glu Gln Phe Lys Asp Asp Glu Gly
    130                 135                 140                 
Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met Leu Ser Leu
145                 150                 155                 160 
Tyr Glu Ala Ala Tyr Met Ala Val Arg Gly Glu His Ile Leu Asp Glu
                165                 170                 175     
Ala Ile Ala Phe Thr Thr Thr His Leu Gln Ser Ala Ala Pro His Leu
            180                 185                 190         
Lys Ser Pro Leu Ala Glu Gln Ile Asn His Ala Leu Tyr Arg Pro Leu
        195                 200                 205             
Arg Lys Thr Leu Pro Arg Leu Glu Ala Arg Tyr Ile Met Ser Val Tyr
    210                 215                 220                 
Gln Asp Glu Ala Phe His Asn Lys Thr Leu Leu Asn Phe Ala Lys Leu
225                 230                 235                 240 
Asp Phe Asn Ile Leu Leu Asp Leu His Lys Glu Glu Leu Asn Glu Leu
                245                 250                 255     
Thr Lys Trp Trp Gln Asp Leu Asp Phe Thr Thr Lys Leu Pro Tyr Ala
            260                 265                 270         
Arg Asp Arg Leu Val Glu Leu Tyr Phe Trp Asp Leu Gly Thr Tyr Phe
        275                 280                 285             
Glu Ser Gln Tyr Ala Phe Gly Arg Lys Ile Met Thr Lys Leu Asn Tyr
    290                 295                 300                 
Ile Leu Ser Ile Ile Asp Asp Thr Tyr Asp Ala Tyr Gly Thr Leu Glu
305                 310                 315                 320 
Glu Cys Thr Met Phe Ser Glu Ala Val Ala Arg Trp Asn Ile Glu Ala
                325                 330                 335     
Val Asp Met Leu Pro Asp Tyr Met Arg Ile Ile Tyr Arg Thr Leu Leu
            340                 345                 350         
Asp Thr Phe Asn Glu Ile Glu Glu Asp Met Ala Lys Gln Arg Arg Ser
        355                 360                 365             
His Cys Val Arg Tyr Ala Lys Glu Glu Ile Gln Lys Val Ile Gly Ala
    370                 375                 380                 
Tyr Tyr Val Gln Ala Lys Trp Phe Ser Glu Gly Tyr Val Pro Thr Ile
385                 390                 395                 400 
Glu Glu Tyr Met Pro Ile Ala Leu Thr Ser Cys Ala Tyr Arg Phe Val
                405                 410                 415     
Ile Thr Asn Ser Phe Leu Gly Met Gly Asp Phe Ala Thr Lys Glu Val
            420                 425                 430         
Phe Glu Trp Ile Ser Gly Asn Pro Lys Val Val Lys Ser Ala Ser Val
        435                 440                 445             
Ile Cys Arg Leu Met Asp Asp Met Gln Gly His Glu Phe Glu Gln Lys
    450                 455                 460                 
Arg Gly His Val Ala Ser Ala Ile Glu Cys Tyr Thr Lys Gln His Gly
465                 470                 475                 480 
Val Ser Lys Glu Glu Ala Ile Lys Met Phe Glu Glu Asp Val Ala Asn
                485                 490                 495     
Ala Trp Lys Asp Ile Asn Glu Glu Leu Met Met Lys Pro Pro Val Val
            500                 505                 510         
Ala Arg Pro Leu Leu Gly Thr Ile Leu Asn Leu Ala Arg Ala Ile Asp
        515                 520                 525             
Phe Ile Tyr Lys Glu Asp Asp Gly Tyr Thr His Ser Tyr Leu Ile Lys
    530                 535                 540                 
Glu Gln Ile Ala Ser Val Leu Gly Asp His Val Pro Phe
545                 550                 555         


<210> 999
<211> 1674
<212> DNA
<213> Artificial Sequence

<220> 
<223> CVS variant V315
      

<400> 999
atgtctactc aagtctcagc atcttctcta gcccagattc cccaacccaa aaatcgtcct 60
gtggcaaact ttcaccccaa catttggggt gaccaattta tcacctacac tcctgaagac 120
aaggttactc gtgcctgcaa agaggagcag attgaagctt tgaaggaaga agttagaaga 180
atgattttag caaccggaag gaaaccaatt caaaaattga gattgattga tgaagttcaa 240
agattgggtg ttgcttacca ttttgaaaaa gaaattgaag atatgttgga tcacatttac 300
agagctgatc cttattttga ggctcatgaa tacaatgatt tgcatactgt ttctttgcat 360
ttcagattgt tgagacaaca aggtattaag atttcttgtg atgttttcga acaatttaag 420
gatgatgaag gtagattcaa aagttctttg attaatgatg ttcaaggcat gttgtctttg 480
tatgaagctg cttatatggc tgttagaggt gaacatattt tggatgaagc tattgcattt 540
actactactc atttgcaatc tgcagctcca catttgaagt cacctttggc tgaacaaatt 600
aaccatgctt tgtatagacc attgagaaaa actttgccaa gattggaagc aagatacatt 660
atgtcagtct accaagatga agctttccat aacaagactt tgttaaattt cgctaagttg 720
gatttcaata ttttgttgga tttgcataaa gaagaattga acgaattgac taaatggtgg 780
caagatttgg attttactac taaattgcca tatgctagag atagattggt tgaactgtac 840
ttttgggatt tggggactta ttttgaatca caatacgctt ttggtagaaa aatcatgact 900
aaattgaact acattttgtc cattattgat gatacctacg atgcttacgg tactttggaa 960
gaatgcacga tgttcagtga agctgttgct cgttggaaca ttgaagctgt tgatatgttg 1020
ccagattata tgcgaattat ctacagaact ttgttggata cattcaacga aatagaagag 1080
gatatggcta aacaacggag atctcattgt gtaagatacg ctaaagaaga aattcaaaag 1140
gttattggtg cttattacgt tcaagctaag tggttttctg aaggttatgt ccctactatt 1200
gaagaataca tgccaattgc tctgacttct tgcgcttaca gatttgttat taccaattct 1260
tttttgggta tgggtgattt cgctacaaag gaagtattcg aatggatttc tggtaatcca 1320
aaagttgtta aatctgcttc tgttatttgt agattgatgg acgatatgca aggacacgaa 1380
tttgaacaaa aaagaggtca cgttgcatct gcaattgaat gctatactaa acaacatggt 1440
gtttccaagg aagaggctat caagatgttc gaggaagatg ttgctaacgc ttggaaggat 1500
atcaatgaag aattaatgat gaaaccacca gttgttgcta gaccattgtt aggtactatt 1560
ttgaatttgg ctagagctat cgattttatc tataaagaag atgacggtta cactcattct 1620
tatttgatta aggaacaaat cgcatctgtt ttgggtgatc atgttccatt ttaa       1674

<210> 1000
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> CVS115-146
      

<400> 1000
Gly Ile Lys Ile Ser Cys Asp Val Phe Glu Lys Phe Lys Asp Asp Glu
 1               5                  10                  15      
Gly Arg Phe Lys Ser Ser Leu Ile Asn Asp Val Gln Gly Met Leu Ser
            20                  25                  30          


<210> 1001
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> VITIS128-159
      

<400> 1001
Gly Tyr Thr Ile Ser Cys Asp Ile Phe Asn Lys Phe Thr Asp Glu Arg
 1               5                  10                  15      
Gly Arg Phe Lys Glu Ala Leu Ile Ser Asp Val Arg Gly Met Leu Gly
            20                  25                  30          


<210> 1002
<211> 68
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer 21-141.3
      

<400> 1002
gctattcaac aattgtgtaa tagttttcat gactgcaatg atatggatgg tgatttgcat 60
actgtttc                                                          68

<210> 1003
<211> 68
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer 21-141.4
      

<400> 1003
gaaacagtat gcaaatcacc atccatatca ttgcagtcat gaaaactatt acacaattgt 60
tgaatagc                                                          68

<210> 1004
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer 21-145.29
      

<400> 1004
catttcagat tgttgagaca acaagggtac actatttcat gtg                   43

<210> 1005
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer 21-145.30
      

<400> 1005
cacatgaaat agtgtaccct tgttgtctca acaatctgaa atg                   43

<210> 1006
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer 21-145.39
      

<400> 1006
gatgtaagag gcatgctagg cttgtatgaa gctgcttata tg                    42

<210> 1007
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer 21-145.40

<400> 1007
catataagca gcttcataca agcctagcat gcctcttaca tc                    42
