
                                SEQUENCE LISTING

<110> Ikuo Hayashi
      John Majercak
      Sanjiv Shah

<120> METHODS FOR IDENTIFYING NOTCH-SPARING
  GAMMA SECRETASE INHIBITORS
  

<130> MRL-NOP-00139

<160> 16

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 1
His His Gln Lys
 1              


<210> 2
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 2
Asp His Gln Glu
 1              


<210> 3
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 3
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys
 1               5                  10                  15      
Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile
            20                  25                  30          
Gly Leu
        


<210> 4
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 4
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Asp His Gln Glu
 1               5                  10                  15      
Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile
            20                  25                  30          
Gly Leu
        


<210> 5
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 5
Lys Met Asp Ala
 1              


<210> 6
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 6
Asn Phe Glu Val
 1              


<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 7
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg
 1               5                  10                  15      
Ala
    


<210> 8
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 8
Leu Gly Thr Glu Leu Gly Ser Thr Ser Pro Val Trp Trp Asn Ser Ala
 1               5                  10                  15      
Asp Ile Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg
            20                  25                  30          
Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys
        35                  40                  45              
Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser
    50                  55                  60                  
Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg
65                  70                  75                  80  
Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met
                85                  90                  95      
Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly
            100                 105                 110         
Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu
        115                 120                 125             
Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile
    130                 135                 140                 
Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln
145                 150                 155                 160 
Leu Thr Val Ser Gly Ile Pro Gly Asp Leu Ala Pro Pro Thr Asp Val
                165                 170                 175     
Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu Asp Val Ala Met Ala
            180                 185                 190         
His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Asp Gly
        195                 200                 205             
Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp Ser Ala Pro Tyr Gly
    210                 215                 220                 
Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln Met Phe Thr Asp Ala
225                 230                 235                 240 
Leu Gly Ile Asp Glu Tyr Gly Gly Asp Ile Gln His Ser Gly Gly Arg
                245                 250                 255     


<210> 9
<211> 46
<212> DNA
<213> Synthetic

<400> 9
gatgcagaat tccgacatga ctcaggatat gaagttcatc atcaag                46

<210> 10
<211> 34
<212> DNA
<213> Synthetic

<400> 10
cgccgccgcc cgagccgtcc aggcggccag cagg                             34

<210> 11
<211> 50
<212> DNA
<213> Synthetic

<400> 11
catgactcag gatatgaagt tgatcatcaa gaattggtgt tctttgcaga            50

<210> 12
<211> 50
<212> DNA
<213> Synthetic

<400> 12
tctgcaaaga acaccaattc ttgatgatca acttcatatc ctgagtcatg            50

<210> 13
<211> 1090
<212> DNA
<213> Synthetic

<400> 13
atgctgcccg gtttggcact gctcctgctg gccgcctgga cggctcgggc ggcggcggat 60
gcagaattcc gacatgactc aggatatgaa gttcatcatc aagtattggt gttctttgca 120
gaagatgtgg gttcaaacaa aggtgcaatc attggactca tggtgggcgg tgttgtcata 180
gcgacagtga tcgtcatcac cttggtgatg ctgaagaaga aaaagcttgg taccgagctc 240
ggatccacta gtccagtgtg gtggaattct gcagatatca agctactgtc ttctatcgaa 300
caagcatgcg atatttgccg acttaaaaag ctcaagtgct ccaaagaaaa accgaagtgc 360
gccaagtgtc tgaagaacaa ctgggagtgt cgctactctc ccaaaaccaa aaggtctccg 420
ctgactaggg cacatctgac agaagtggaa tcaaggctag aaagactgga acagctattt 480
ctactgattt ttcctcgaga agaccttgac atgattttga aaatggattc tttacaggat 540
ataaaagcat tgttaacagg attatttgta caagataatg tgaataaaga tgccgtcaca 600
gatagattgg cttcagtgga gactgatatg cctctaacat tgagacagca tagaataagt 660
gcgacatcat catcggaaga gagtagtaac aaaggtcaaa gacagttgac tgtatcggga 720
attcccgggg atctggcccc cccgaccgat gtcagcctgg gggacgagct ccacttagac 780
ggcgaggacg tggcgatggc gcatgccgac gcgctagacg atttcgatct ggacatgttg 840
ggggacgggg attccccggg tccgggattt accccccacg actccgcccc ctacggcgct 900
ctggatatgg ccgacttcga gtttgagcag atgtttaccg atgcccttgg aattgacgag 960
tacggtgggg atatccagca cagtggcggc cgcgacgccg ctgtcacccc agaggagcgc 1020
cacctgtcca agatgcagca gaacggctac gaaaatccaa cctacaagtt ctttgagcag 1080
atgcagaact                                                        1090

<210> 14
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 14
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg
 1               5                  10                  15      
Ala Ala Ala Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His
            20                  25                  30          
His Gln Val Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly
        35                  40                  45              
Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile
    50                  55                  60                  
Val Ile Thr Leu Val Met Leu Lys Lys Lys Lys Leu Gly Thr Glu Leu
65                  70                  75                  80  
Gly Ser Thr Ser Pro Val Trp Trp Asn Ser Ala Asp Ile Lys Leu Leu
                85                  90                  95      
Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys
            100                 105                 110         
Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp
        115                 120                 125             
Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala
    130                 135                 140                 
His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe
145                 150                 155                 160 
Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp
                165                 170                 175     
Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp
            180                 185                 190         
Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr
        195                 200                 205             
Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser
    210                 215                 220                 
Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Gly
225                 230                 235                 240 
Ile Pro Gly Asp Leu Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu
                245                 250                 255     
Leu His Leu Asp Gly Glu Asp Val Ala Met Ala His Ala Asp Ala Leu
            260                 265                 270         
Asp Asp Phe Asp Leu Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro
        275                 280                 285             
Gly Phe Thr Pro His Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala
    290                 295                 300                 
Asp Phe Glu Phe Glu Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu
305                 310                 315                 320 
Tyr Gly Gly Asp Ile Gln His Ser Gly Gly Arg Asp Ala Ala Val Thr
                325                 330                 335     
Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn
            340                 345                 350         
Pro Thr Tyr Lys Phe Phe Glu Gln Met Gln Asn
        355                 360             


<210> 15
<211> 1090
<212> DNA
<213> Synthetic

<400> 15
atgctgcccg gtttggcact gctcctgctg gccgcctgga cggctcgggc ggcggcggat 60
gcagaattcc gacatgactc aggatatgaa gttgatcatc aagaattggt gttctttgca 120
gaagatgtgg gttcaaacaa aggtgcaatc attggactca tggtgggcgg tgttgtcata 180
gcgacagtga tcgtcatcac cttggtgatg ctgaagaaga aaaagcttgg taccgagctc 240
ggatccacta gtccagtgtg gtggaattct gcagatatca agctactgtc ttctatcgaa 300
caagcatgcg atatttgccg acttaaaaag ctcaagtgct ccaaagaaaa accgaagtgc 360
gccaagtgtc tgaagaacaa ctgggagtgt cgctactctc ccaaaaccaa aaggtctccg 420
ctgactaggg cacatctgac agaagtggaa tcaaggctag aaagactgga acagctattt 480
ctactgattt ttcctcgaga agaccttgac atgattttga aaatggattc tttacaggat 540
ataaaagcat tgttaacagg attatttgta caagataatg tgaataaaga tgccgtcaca 600
gatagattgg cttcagtgga gactgatatg cctctaacat tgagacagca tagaataagt 660
gcgacatcat catcggaaga gagtagtaac aaaggtcaaa gacagttgac tgtatcggga 720
attcccgggg atctggcccc cccgaccgat gtcagcctgg gggacgagct ccacttagac 780
ggcgaggacg tggcgatggc gcatgccgac gcgctagacg atttcgatct ggacatgttg 840
ggggacgggg attccccggg tccgggattt accccccacg actccgcccc ctacggcgct 900
ctggatatgg ccgacttcga gtttgagcag atgtttaccg atgcccttgg aattgacgag 960
tacggtgggg atatccagca cagtggcggc cgcgacgccg ctgtcacccc agaggagcgc 1020
cacctgtcca agatgcagca gaacggctac gaaaatccaa cctacaagtt ctttgagcag 1080
atgcagaact                                                        1090

<210> 16
<211> 363
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 16
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg
 1               5                  10                  15      
Ala Ala Ala Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val Asp
            20                  25                  30          
His Gln Glu Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly
        35                  40                  45              
Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile
    50                  55                  60                  
Val Ile Thr Leu Val Met Leu Lys Lys Lys Lys Leu Gly Thr Glu Leu
65                  70                  75                  80  
Gly Ser Thr Ser Pro Val Trp Trp Asn Ser Ala Asp Ile Lys Leu Leu
                85                  90                  95      
Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys
            100                 105                 110         
Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp
        115                 120                 125             
Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala
    130                 135                 140                 
His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe
145                 150                 155                 160 
Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp
                165                 170                 175     
Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp
            180                 185                 190         
Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr
        195                 200                 205             
Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser
    210                 215                 220                 
Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Gly
225                 230                 235                 240 
Ile Pro Gly Asp Leu Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu
                245                 250                 255     
Leu His Leu Asp Gly Glu Asp Val Ala Met Ala His Ala Asp Ala Leu
            260                 265                 270         
Asp Asp Phe Asp Leu Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro
        275                 280                 285             
Gly Phe Thr Pro His Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala
    290                 295                 300                 
Asp Phe Glu Phe Glu Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu
305                 310                 315                 320 
Tyr Gly Gly Asp Ile Gln His Ser Gly Gly Arg Asp Ala Ala Val Thr
                325                 330                 335     
Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn
            340                 345                 350         
Pro Thr Tyr Lys Phe Phe Glu Gln Met Gln Asn
        355                 360             

