                         SEQUENCE LISTING



<110>  Technion Research & Development Foundation Ltd.

       Oregon Health & Science University

       The United States Government as represented by the 

       Department of Veterans Affairs

       Reiter, Yoram

       Dahan, Rony

       Vandenbark, Arthur A.

 

<120>  ANTIBODIES WHICH BIND SOLUBLE T-CELL RECEPTOR LIGANDS



<130>  52323



<150>  US 61/406,609

<151>  2010-10-26



<160>  456   



<170>  PatentIn version 3.5



<210>  1

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2E4 light chain CDR 1



<400>  1



Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 

1               5                   10      





<210>  2

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2E4 light chain CDR 2



<400>  2



Asp Ala Ser Asn Arg Ala Thr 

1               5           





<210>  3

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2E4 light chain CDR 3



<400>  3



Gln Gln Arg Ser Asn Trp Pro Pro Ser Tyr Thr 

1               5                   10      





<210>  4

<211>  33

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2E4 light chain CDR1



<400>  4

agggccagtc agagtgttag cagctactta gcc                                    33





<210>  5

<211>  21

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2E4 light chain CDR2



<400>  5

gatgcatcca acagggccac t                                                 21





<210>  6

<211>  33

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2E4 light chain CDR3



<400>  6

cagcagcgta gcaactggcc tccctcgtac act                                    33





<210>  7

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2E4 heavy chain CDR 1



<400>  7



Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His 

1               5                   10  





<210>  8

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2E4 heavy chain CDR 2



<400>  8



Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 

1               5                   10                  15      





<210>  9

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2E4 heavy chain CDR 3



<400>  9



Glu Gly Asp Asn Tyr Tyr Gly Asp Ala Phe Asp Ile 

1               5                   10          





<210>  10

<211>  30

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2E4 Heavy chain CDR1



<400>  10

ggatacacct tcaccagcta ctatatgcac                                        30





<210>  11

<211>  51

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2E4 Heavy chain CDR2



<400>  11

ataatcaacc ctagtggtgg tagcacaagc tacgcacaga agttccaggg c                51





<210>  12

<211>  36

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2E4 Heavy chain CDR3



<400>  12

gagggagata attactatgg tgatgctttt gatatc                                 36





<210>  13

<211>  217

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2E4 Fab light chain



<400>  13



Leu Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 

1               5                   10                  15      





Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 

            20                  25                  30          





Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 

        35                  40                  45              





Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 

    50                  55                  60                  





Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 

65                  70                  75                  80  





Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro 

                85                  90                  95      





Pro Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 

            100                 105                 110         





Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 

        115                 120                 125             





Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 

    130                 135                 140                 





Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 

145                 150                 155                 160 





Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 

                165                 170                 175     





Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 

            180                 185                 190         





Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 

        195                 200                 205             





Thr Lys Ser Phe Asn Arg Gly Glu Cys 

    210                 215         





<210>  14

<211>  651

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2E4 Fab light chain



<400>  14

cttgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg ggaaagagcc       60



accctctcct gcagggccag tcagagtgtt agcagctact tagcctggta ccaacagaaa      120



cctggccagg ctcccaggct cctcatctat gatgcatcca acagggccac tggcatccca      180



gccaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctagag      240



cctgaagatt ttgcagttta ttactgtcag cagcgtagca actggcctcc ctcgtacact      300



tttggccagg ggaccaagct ggagatcaaa cgaactgtgg ctgcaccatc tgtcttcatc      360



ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420



aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480



aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540



accctgacgc tgagcaaagc agactacgag aaacacaaac tctacgcctg cgaagtcacc      600



catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651





<210>  15

<211>  250

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2E4 Fab heavy chain



<400>  15



Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 

1               5                   10                  15      





Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 

            20                  25                  30          





Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 

        35                  40                  45              





Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 

    50                  55                  60                  





Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 

65                  70                  75                  80  





Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Arg Glu Gly Asp Asn Tyr Tyr Gly Asp Ala Phe Asp Ile Trp Gly 

            100                 105                 110         





Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 

        115                 120                 125             





Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 

    130                 135                 140                 





Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 

145                 150                 155                 160 





Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 

                165                 170                 175     





Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 

            180                 185                 190         





Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 

        195                 200                 205             





Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 

    210                 215                 220                 





Ala Ala Ala His His His His His His Gly Ala Ala Glu Gln Lys Leu 

225                 230                 235                 240 





Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala 

                245                 250 





<210>  16

<211>  753

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2E4 Fab heavy chain



<400>  16

gccgaggtgc agctggtgga gtccggggct gaggtgaaga agcctggggc ctcagtgaag       60



gtttcctgca aggcatctgg atacaccttc accagctact atatgcactg ggtgcggcag      120



gcccccggac aagggcttga gtggatggga ataatcaacc ctagtggtgg tagcacaagc      180



tacgcacaga agttccaggg cagagtcacc atgaccaggg acacgtccac gagcacagtc      240



tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgctagagag      300



ggagataatt actatggtga tgcttttgat atctggggcc aagggacaat ggtcaccgtc      360



tcaagcgcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420



tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480



gtgtcgtgga actcaggcgc cctgaccagc ggcgtccaca ccttcccggc tgtcctacag      540



tcctcaggac tctactccct cagcagcgta gtgaccgtgc cctccagcag cttgggcacc      600



cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      660



gagcccaaat cttgtgcggc cgcacatcat catcaccatc acggggccgc agaacaaaaa      720



ctcatctcag aagaggatct gaatggggcc gca                                   753





<210>  17

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1F11 light chain CDR 1



<400>  17



Arg Ala Ser Gln Ser Ile Ile Asn Ser His Leu Ala 

1               5                   10          





<210>  18

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1F11 light chain CDR 2



<400>  18



Gly Ala Ser Ser Arg Ala Thr 

1               5           





<210>  19

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1F11 light chain CDR 3



<400>  19



Gln Gln Tyr Gly Thr Ser Pro Leu Thr 

1               5                   





<210>  20

<211>  36

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1F11 light chain CDR1



<400>  20

agggccagtc agagtattat caacagccac ttagcc                                 36





<210>  21

<211>  21

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1F11 light chain CDR2



<400>  21

ggtgcatcca gcagggccac t                                                 21





<210>  22

<211>  27

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1F11 light chain CDR3



<400>  22

cagcagtatg gaacctctcc tctcact                                           27





<210>  23

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1F11 heavy chain CDR 1



<400>  23



Gly Val Ser Ile Ser Ser Arg Ser Gly His Trp Gly 

1               5                   10          





<210>  24

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1F11 heavy chain CDR 2



<400>  24



Ser Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 

1               5                   10                  15      





<210>  25

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1F11 heavy chain CDR 3



<400>  25



Glu Ser His Pro Ala Ala Ala Leu Val Gly 

1               5                   10  





<210>  26

<211>  36

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1F11 heavy chain  CDR1



<400>  26

ggtgtctcca tcagcagtag aagtggccac tggggc                                 36





<210>  27

<211>  48

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1F11 heavy chain  CDR2



<400>  27

agtatctctt atagtgggag cacctactac aacccgtccc tcaagagc                    48





<210>  28

<211>  30

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1F11 heavy chain  CDR3



<400>  28

gagtcgcacc cagcagctgc actggttggg                                        30





<210>  29

<211>  216

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1F11 Fab light chain



<400>  29



Leu Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 

1               5                   10                  15      





Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ile Asn 

            20                  25                  30          





Ser His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 

        35                  40                  45              





Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 

    50                  55                  60                  





Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu 

65                  70                  75                  80  





Glu Thr Glu Asp Phe Ala Leu Tyr Phe Cys Gln Gln Tyr Gly Thr Ser 

                85                  90                  95      





Pro Leu Thr Phe Gly Gly Gly Thr Arg Val Glu Thr Lys Arg Thr Val 

            100                 105                 110         





Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 

        115                 120                 125             





Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 

    130                 135                 140                 





Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 

145                 150                 155                 160 





Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 

                165                 170                 175     





Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 

            180                 185                 190         





Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 

        195                 200                 205             





Lys Ser Phe Asn Arg Gly Glu Cys 

    210                 215     





<210>  30

<211>  648

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1F11 Fab light chain



<400>  30

cttgaaacga cactcacgca gtctccaggc accctgtctt tgtctccagg ggaaagagcc       60



accctctcct gcagggccag tcagagtatt atcaacagcc acttagcctg gtaccagcag      120



aaacctggcc aggctcccag gctcctcatc tatggtgcat ccagcagggc cactggcatc      180



ccagacaggt tcagtggcgg tgggtctggg acagacttca ctctcaccat caccagactg      240



gaaactgaag attttgcact atatttctgc cagcagtatg gaacctctcc tctcactttc      300



ggcggaggga ccagggttga gaccaaacga actgtggctg caccatctgt cttcatcttc      360



ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420



ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480



tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540



ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600



caaggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648





<210>  31

<211>  249

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1F11 Fab  heavy chain



<400>  31



Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 

1               5                   10                  15      





Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Ile Ser Ser Arg 

            20                  25                  30          





Ser Gly His Trp Gly Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 

        35                  40                  45              





Trp Ile Gly Ser Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 

    50                  55                  60                  





Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu 

65                  70                  75                  80  





Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 

                85                  90                  95      





Cys Ala Arg Glu Ser His Pro Ala Ala Ala Leu Val Gly Trp Gly Gln 

            100                 105                 110         





Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 

        115                 120                 125             





Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 

    130                 135                 140                 





Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 

145                 150                 155                 160 





Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 

                165                 170                 175     





Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 

            180                 185                 190         





Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 

        195                 200                 205             





Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ala 

    210                 215                 220                 





Ala Ala His His His His His His Gly Ala Ala Glu Gln Lys Leu Ile 

225                 230                 235                 240 





Ser Glu Glu Asp Leu Asn Gly Ala Ala 

                245                 





<210>  32

<211>  747

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1F11 Fab  heavy chain



<400>  32

cagctgcagc tgcaggagtc cggcccagga ctggtgaagc cttcggagac cctgtccctc       60



acctgcactg tctctggtgt ctccatcagc agtagaagtg gccactgggg ctgggtccgc      120



cagcccccag ggaaggggct ggagtggatt ggaagtatct cttatagtgg gagcacctac      180



tacaacccgt ccctcaagag ccgagtcacc atatccgtag acacctccaa gaaccaactc      240



tccctgaagc tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgagagag      300



tcgcacccag cagctgcact ggttgggtgg ggccagggca ccctggtcac cgtctcaagc      360



gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420



ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480



tggaactcag gcgccctgac cagcggcgtc cacaccttcc cggctgtcct acagtcctca      540



ggactctact ccctcagcag cgtagtgacc gtgccctcca gcagcttggg cacccagacc      600



tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660



aaatcttgtg cggccgcaca tcatcatcac catcacgggg ccgcagaaca aaaactcatc      720



tcagaagagg atctgaatgg ggccgca                                          747





<210>  33

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3A3 light chain CDR 1



<400>  33



Arg Ala Ser Gln Val Ile Ser Ser Trp Leu Ala 

1               5                   10      





<210>  34

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3A3 light chain CDR 2



<400>  34



Thr Ala Ser Ser Leu Gln Ser 

1               5           





<210>  35

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3A3 light chain CDR 3



<400>  35



Gln Gln Ala Asn Ser Phe Pro Leu Thr 

1               5                   





<210>  36

<211>  33

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3A3 light chain CDR1



<400>  36

cgggcgagtc aggttattag cagctggtta gcc                                    33





<210>  37

<211>  21

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3A3 light chain CDR2



<400>  37

actgcatcca gtttgcaaag t                                                 21





<210>  38

<211>  27

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3A3 light chain CDR3



<400>  38

caacaggcta acagtttccc cctgacg                                           27





<210>  39

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3A3 heavy chain CDR 1



<400>  39



Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn 

1               5                   10  





<210>  40

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3A3 heavy chain CDR 2



<400>  40



Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 

1               5                   10                  15      





Gly 

    





<210>  41

<211>  26

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3A3 heavy chain CDR 3



<400>  41



Val Arg Gly His Arg Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Ser Ser 

1               5                   10                  15      





Asp Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 

            20                  25      





<210>  42

<211>  30

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3A3 heavy chain CDR1



<400>  42

ggattcacct tcagtagcta tagcatgaac                                        30





<210>  43

<211>  51

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3A3 heavy chain CDR2



<400>  43

tccattagta gtagtagtag ttacatatac tacgcagact cagtgaaggg c                51





<210>  44

<211>  78

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3A3 heavy chain CDR3



<400>  44

gtcagggggc accggtatta ctatgatagt agtggttatt actcatccga ttactactac       60



tactacggta tggacgtc                                                     78





<210>  45

<211>  215

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3A3 Fab light chain



<400>  45



Leu Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val 

1               5                   10                  15      





Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Val Ile Ser Ser 

            20                  25                  30          





Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 

        35                  40                  45              





Ile Ser Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Pro Arg Phe Ser 

    50                  55                  60                  





Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln 

65                  70                  75                  80  





Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro 

                85                  90                  95      





Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 

            100                 105                 110         





Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 

        115                 120                 125             





Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 

    130                 135                 140                 





Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 

145                 150                 155                 160 





Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 

                165                 170                 175     





Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 

            180                 185                 190         





Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 

        195                 200                 205             





Ser Phe Asn Arg Gly Glu Cys 

    210                 215 





<210>  46

<211>  645

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3A3 Fab light chain



<400>  46

cttgacatcc agttgaccca gtctccatct tccgtgtctg catctgtagg ggacagagtc       60



accatcactt gtcgggcgag tcaggttatt agcagctggt tagcctggta tcagcaaaaa      120



ccagggaaag cccctaagct cctgatctct actgcatcca gtttgcaaag tggggtccca      180



ccaaggttca gcggcagtgg gtctgggaca gatttcactc tcaccatcac cagcctgcag      240



cctgaagatt ttgcaactta ctattgtcaa caggctaaca gtttccccct gacgttcggc      300



caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      360



ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420



tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480



caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540



acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600



ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645





<210>  47

<211>  264

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3A3 Fab heavy chain



<400>  47



Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 

            20                  25                  30          





Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 

        35                  40                  45              





Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Arg Val Arg Gly His Arg Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr 

            100                 105                 110         





Ser Ser Asp Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 

        115                 120                 125             





Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 

    130                 135                 140                 





Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 

145                 150                 155                 160 





Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 

                165                 170                 175     





Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 

            180                 185                 190         





Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 

        195                 200                 205             





Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 

    210                 215                 220                 





Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ala Ala 

225                 230                 235                 240 





Ala His His His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser 

                245                 250                 255     





Glu Glu Asp Leu Asn Gly Ala Ala 

            260                 





<210>  48

<211>  792

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3A3 Fab heavy chain



<400>  48

caggtgcagc tgcaggagtc ggggggaggc ctggtcaagc ctggggggtc cctgagactc       60



tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct      120



ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac      180



gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240



ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagggtcagg      300



gggcaccggt attactatga tagtagtggt tattactcat ccgattacta ctactactac      360



ggtatggacg tctggggcca agggaccacg gtcaccgtct caagcgcctc caccaagggc      420



ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480



ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540



ctgaccagcg gcgtccacac cttcccggct gtcctacagt cctcaggact ctactccctc      600



agcagcgtag tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660



aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgcggcc      720



gcacatcatc atcaccatca cggggccgca gaacaaaaac tcatctcaga agaggatctg      780



aatggggccg ca                                                          792





<210>  49

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3H5 light chain CDR 1



<400>  49



Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Asn Tyr Leu Asp 

1               5                   10                  15      





<210>  50

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3H5 light chain CDR 2



<400>  50



Leu Gly Ser Asn Arg Ala Ser 

1               5           





<210>  51

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3H5 light chain CDR 3



<400>  51



Met Gln Ala Leu Gln Thr Pro Leu Thr 

1               5                   





<210>  52

<211>  48

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3H5 light chain CDR1



<400>  52

aggtctagtc agagcctctt gcatagtaat ggaaacaact atttggat                    48





<210>  53

<211>  21

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3H5 light chain CDR2



<400>  53

ttgggttcta atcgggcctc c                                                 21





<210>  54

<211>  27

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3H5 light chain CDR3



<400>  54

atgcaagctc ttcaaactcc gctcacc                                           27





<210>  55

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3H5 heavy chain CDR 1



<400>  55



Gly Gly Ser Ile Ser Gly Tyr Tyr Trp Ser 

1               5                   10  





<210>  56

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3H5 heavy chain CDR 2



<400>  56



Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 

1               5                   10                  15      





<210>  57

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3H5 heavy chain CDR 3



<400>  57



Asp Glu Arg Asp Ala Tyr Tyr Tyr Gly Met Asp Val 

1               5                   10          





<210>  58

<211>  30

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3H5 heavy chain CDR1



<400>  58

ggtggctcca tcagcggtta ctactggagc                                        30





<210>  59

<211>  48

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3H5 heavy chain CDR2



<400>  59

tatatctatt acagtgggag caccaactac aacccctccc tcaagagt                    48





<210>  60

<211>  36

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3H5 heavy chain CDR3



<400>  60

gatgaaaggg acgcctacta ctacggtatg gacgtc                                 36





<210>  61

<211>  220

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3H5 Fab light chain



<400>  61



Leu Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 

1               5                   10                  15      





Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His 

            20                  25                  30          





Ser Asn Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 

        35                  40                  45              





Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val 

    50                  55                  60                  





Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 

65                  70                  75                  80  





Ile Thr Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 

                85                  90                  95      





Ala Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Met Glu Ile 

            100                 105                 110         





Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 

        115                 120                 125             





Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 

    130                 135                 140                 





Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 

145                 150                 155                 160 





Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 

                165                 170                 175     





Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 

            180                 185                 190         





Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 

        195                 200                 205             





Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 

    210                 215                 220 





<210>  62

<211>  660

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3H5 Fab light chain



<400>  62

cttgaaattg tgatgacgca gtctccactc tccctgcccg tcacccctgg agagccggcc       60



tccatctcct gcaggtctag tcagagcctc ttgcatagta atggaaacaa ctatttggat      120



tggtacctgc agaagccagg gcagtctcca cagctcctga tctatttggg ttctaatcgg      180



gcctccgggg tccctgacag gttcagtggc agtggatcgg gcacagattt tacactgaaa      240



atcaccagag tggaggctga ggatgttggg gtttattact gcatgcaagc tcttcaaact      300



ccgctcacct tcggcggagg gaccaagatg gagatcaaac gaactgtggc tgcaccatct      360



gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420



ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480



caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540



ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600



gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660





<210>  63

<211>  249

<212>  PRT

<213>  Artificial sequence



<220>

<223>  3H5 Fab  heavy chain



<400>  63



Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 

1               5                   10                  15      





Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Gly Tyr 

            20                  25                  30          





Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 

        35                  40                  45              





Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 

    50                  55                  60                  





Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 

65                  70                  75                  80  





Arg Leu Ser Ser Val Thr Ala Ala Asp Ser Ala Val Tyr Phe Cys Ala 

                85                  90                  95      





Arg Asp Glu Arg Asp Ala Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 

            100                 105                 110         





Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 

        115                 120                 125             





Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 

    130                 135                 140                 





Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 

145                 150                 155                 160 





Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 

                165                 170                 175     





Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 

            180                 185                 190         





Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 

        195                 200                 205             





Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ala 

    210                 215                 220                 





Ala Ala His His His His His His Gly Ala Ala Glu Gln Lys Leu Ile 

225                 230                 235                 240 





Ser Glu Glu Asp Leu Asn Gly Ala Ala 

                245                 





<210>  64

<211>  747

<212>  DNA

<213>  Artificial sequence



<220>

<223>  3H5 Fab  heavy chain



<400>  64

caggtgcagc tgcaggagtc cggcccagga ctggtgaagc cttcggagac cctgtccctc       60



acctgcactg tctctggtgg ctccatcagc ggttactact ggagctggat ccggcagccc      120



ccagggaagg gactggagtg gattggctat atctattaca gtgggagcac caactacaac      180



ccctccctca agagtcgagt cagcatatca gtagacacgt ccaagaacca gttctccctg      240



aggctgagct ccgtgacggc cgcggactcg gccgtgtatt tctgtgcgag agatgaaagg      300



gacgcctact actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcaagc      360



gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420



ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480



tggaactcag gcgccctgac cagcggcgtc cacaccttcc cggctgtcct acagtcctca      540



ggactctact ccctcagcag cgtagtgacc gtgccctcca gcagcttggg cacccagacc      600



tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660



aaatcttgtg cggccgcaca tcatcatcac catcacgggg ccgcagaaca aaaactcatc      720



tcagaagagg atctgaatgg ggccgca                                          747





<210>  65

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2C3 light chain CDR 1



<400>  65



Arg Ser Ser Gln Ser Leu Leu His Ser Asp Gly Asn Asn Tyr Leu Asp 

1               5                   10                  15      





<210>  66

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2C3 light chain CDR 2



<400>  66



Leu Gly Ser Asn Arg Ala Ser 

1               5           





<210>  67

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2C3 light chain CDR 3



<400>  67



Met Gln Ala Leu His Ile Pro Leu Thr 

1               5                   





<210>  68

<211>  48

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2C3 light chain CDR1



<400>  68

aggtctagtc agagcctcct gcatagtgat ggaaacaact atttggat                    48





<210>  69

<211>  21

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2C3 light chain CDR2



<400>  69

ttgggttcta atcgggcctc c                                                 21





<210>  70

<211>  27

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2C3 light chain CDR3



<400>  70

atgcaagctc tacatattcc gctcacc                                           27





<210>  71

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2C3 heavy chain CDR 1



<400>  71



Gly Phe Thr Phe Ser Ser Tyr Ala Met His 

1               5                   10  





<210>  72

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2C3 heavy chain CDR 2



<400>  72



Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 

1               5                   10                  15      





Gly 

    





<210>  73

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2C3 heavy chain CDR 3



<400>  73



Asp Arg Ser Phe Trp Ser Gly Tyr Tyr Ile Ile Asn Tyr Tyr Tyr Tyr 

1               5                   10                  15      





Gly Met Asp Val 

            20  





<210>  74

<211>  30

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2C3 heavy chain CDR1



<400>  74

ggattcacct tcagtagcta tgctatgcac                                        30





<210>  75

<211>  51

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2C3 heavy chain CDR2



<400>  75

gttatatcat atgatggaag caataaatac tacgcagact ccgtgaaggg c                51





<210>  76

<211>  60

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2C3 heavy chain CDR3



<400>  76

gatcgctcct tttggagtgg ttattatata attaactact actactacgg tatggacgtc       60





<210>  77

<211>  220

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2C3 Fab light chain



<400>  77



Leu Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 

1               5                   10                  15      





Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His 

            20                  25                  30          





Ser Asp Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 

        35                  40                  45              





Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val 

    50                  55                  60                  





Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 

65                  70                  75                  80  





Ile Ser Arg Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 

                85                  90                  95      





Ala Leu His Ile Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 

            100                 105                 110         





Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 

        115                 120                 125             





Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 

    130                 135                 140                 





Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 

145                 150                 155                 160 





Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Arg Asp 

                165                 170                 175     





Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 

            180                 185                 190         





Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 

        195                 200                 205             





Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 

    210                 215                 220 





<210>  78

<211>  660

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2C3 Fab light chain



<400>  78

cttgatgttg tgatgactca gtctccactc tccctgcccg tcacacctgg agagccggcc       60



tccatctcct gcaggtctag tcagagcctc ctgcatagtg atggaaacaa ctatttggat      120



tggtacctgc agaagccagg gcagtctcca cagctcctga tctatttggg ttctaatcgg      180



gcctccgggg tccctgacag gttcagtggc agtggatcag gcacagattt tacactgaaa      240



atcagcagag tggagcctga ggatgtcggg gtttattact gcatgcaagc tctacatatt      300



ccgctcacct tcggccaagg gacacgactg gagattaagc gaactgtggc tgcaccatct      360



gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420



ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480



caatcgggta actcccagga gagtgtcaca gagcaggaca gcagggacag cacctacagc      540



ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600



gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660





<210>  79

<211>  258

<212>  PRT

<213>  Artificial sequence



<220>

<223>  2C3 Fab heavy chain



<400>  79



Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 

            20                  25                  30          





Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 

        35                  40                  45              





Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Arg Asp Arg Ser Phe Trp Ser Gly Tyr Tyr Ile Ile Asn Tyr Tyr 

            100                 105                 110         





Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 

        115                 120                 125             





Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 

    130                 135                 140                 





Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 

145                 150                 155                 160 





Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 

                165                 170                 175     





Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 

            180                 185                 190         





Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 

        195                 200                 205             





Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 

    210                 215                 220                 





Lys Lys Val Glu Pro Lys Ser Cys Ala Ala Ala His His His His His 

225                 230                 235                 240 





His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 

                245                 250                 255     





Ala Ala 

        





<210>  80

<211>  774

<212>  DNA

<213>  Artificial sequence



<220>

<223>  2C3 Fab heavy chain



<400>  80

caggtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60



tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct      120



ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac      180



gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240



ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatcgc      300



tccttttgga gtggttatta tataattaac tactactact acggtatgga cgtctggggc      360



caagggacca cggtcaccgt ctcaagcgcc tccaccaagg gcccatcggt cttccccctg      420



gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      480



tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtccac      540



accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt agtgaccgtg      600



ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      660



accaaggtgg acaagaaagt tgagcccaaa tcttgtgcgg ccgcacatca tcatcaccat      720



cacggggccg cagaacaaaa actcatctca gaagaggatc tgaatggggc cgca            774





<210>  81

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1B11 light chain CDR1



<400>  81



Arg Ala Ser Gln Asn Ile Gly Ser Ile Leu Ala 

1               5                   10      





<210>  82

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1B11 light chain CDR2



<400>  82



Gly Ala Ser Thr Arg Ala Thr 

1               5           





<210>  83

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1B11 light chain CDR3



<400>  83



Gln Gln Tyr Leu Tyr Trp Pro Phe Thr 

1               5                   





<210>  84

<211>  33

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1B11 light chain CDR1



<400>  84

agggccagtc agaatattgg cagcatctta gcc                                    33





<210>  85

<211>  21

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1B11 light chain CDR2



<400>  85

ggtgcatcca ccagggccac t                                                 21





<210>  86

<211>  27

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1B11 light chain CDR3



<400>  86

cagcaatatc tttactggcc gttcact                                           27





<210>  87

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1B11 heavy chain CDR1



<400>  87



Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser 

1               5                   10  





<210>  88

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1B11 heavy chain CDR2



<400>  88



Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 

1               5                   10                  15      





Gly 

    





<210>  89

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1B11 heavy chain CDR3



<400>  89



Asp Ile Arg Ala Tyr Gly Ser Gly Ser Tyr Ser Arg Tyr Tyr Tyr Tyr 

1               5                   10                  15      





Gly Met Asp Val 

            20  





<210>  90

<211>  30

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1B11 heavy chain CDR1



<400>  90

ggttacacct ttaccagcta tggtatcagc                                        30





<210>  91

<211>  51

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1B11 heavy chain CDR2



<400>  91

tggatcagcg cttacaatgg taacacaaac tatgcacaga agctccaggg c                51





<210>  92

<211>  60

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1B11 heavy chain CDR3



<400>  92

gatattcggg cctatggttc ggggagttat tcgcgctact actactacgg tatggacgtc       60





<210>  93

<211>  215

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1B11 Fab light chain



<400>  93



Leu Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro 

1               5                   10                  15      





Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Gly Ser 

            20                  25                  30          





Ile Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 

        35                  40                  45              





Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 

    50                  55                  60                  





Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 

65                  70                  75                  80  





Ser Asp Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Leu Tyr Trp Pro 

                85                  90                  95      





Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 

            100                 105                 110         





Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 

        115                 120                 125             





Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 

    130                 135                 140                 





Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 

145                 150                 155                 160 





Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 

                165                 170                 175     





Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 

            180                 185                 190         





Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 

        195                 200                 205             





Ser Phe Asn Arg Gly Glu Cys 

    210                 215 





<210>  94

<211>  645

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1B11 Fab light chain



<400>  94

cttgaaattg tgttgacaca gtctccagcc accctgtctg tgtctccagg agaaagagcc       60



accctctcct gcagggccag tcagaatatt ggcagcatct tagcctggta ccagcacaaa      120



cctggccagg ctcccaggct cctcatctat ggtgcatcca ccagggccac tggtatccca      180



gccaggttca gtggcagtgg gtctgggaca gagttcactc ttaccatcag cagcctgcag      240



tctgacgatt ttgcagttta ttactgtcag caatatcttt actggccgtt cactttcggc      300



ggagggacca aggtggagat caaacgaact gtggctgcac catctgtctt catcttcccg      360



ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420



tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480



caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540



acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600



ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645





<210>  95

<211>  258

<212>  PRT

<213>  Artificial sequence



<220>

<223>  1B11 Fab heavy chain



<400>  95



Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 

1               5                   10                  15      





Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 

            20                  25                  30          





Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 

        35                  40                  45              





Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 

    50                  55                  60                  





Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 

65                  70                  75                  80  





Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Arg Asp Ile Arg Ala Tyr Gly Ser Gly Ser Tyr Ser Arg Tyr Tyr 

            100                 105                 110         





Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 

        115                 120                 125             





Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 

    130                 135                 140                 





Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 

145                 150                 155                 160 





Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 

                165                 170                 175     





Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 

            180                 185                 190         





Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 

        195                 200                 205             





Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 

    210                 215                 220                 





Lys Lys Val Glu Pro Lys Ser Cys Ala Ala Ala His His His His His 

225                 230                 235                 240 





His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 

                245                 250                 255     





Ala Ala 

        





<210>  96

<211>  774

<212>  DNA

<213>  Artificial sequence



<220>

<223>  1B11 Fab heavy chain



<400>  96

gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgagggtc       60



tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120



cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180



gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240



atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatatt      300



cgggcctatg gttcggggag ttattcgcgc tactactact acggtatgga cgtctggggc      360



caagggacca cggtcaccgt ctcaagcgcc tccaccaagg gcccatcggt cttccccctg      420



gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      480



tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtccac      540



accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt agtgaccgtg      600



ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac      660



accaaggtgg acaagaaagt tgagcccaaa tcttgtgcgg ccgcacatca tcatcaccat      720



cacggggccg cagaacaaaa actcatctca gaagaggatc tgaatggggc cgca            774





<210>  97

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  D2 light chain CDR1



<400>  97



Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 

1               5                   10      





<210>  98

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  D2 light chain CDR2



<400>  98



Asp Ala Ser Asn Arg Ala Thr 

1               5           





<210>  99

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  D2 light chain CDR3



<400>  99



Gln Gln Arg Ser Asn Trp Pro Leu Thr 

1               5                   





<210>  100

<211>  33

<212>  DNA

<213>  Artificial sequence



<220>

<223>  D2 light chain CDR1



<400>  100

agggccagtc agagtgttag cagctactta gcc                                    33





<210>  101

<211>  21

<212>  DNA

<213>  Artificial sequence



<220>

<223>  D2 light chain CDR2



<400>  101

gatgcatcca acagggccac t                                                 21





<210>  102

<211>  27

<212>  DNA

<213>  Artificial sequence



<220>

<223>  D2 light chain CDR3



<400>  102

cagcagcgta gcaactggcc gctcact                                           27





<210>  103

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  D2 heavy chain CDR1



<400>  103



Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser 

1               5                   10  





<210>  104

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  D2 heavy chain CDR2



<400>  104



Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 

1               5                   10                  15      





Gly 

    





<210>  105

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  D2 heavy chain CDR3



<400>  105



Gly Gly Pro Thr Gly Ile Phe Asp Tyr 

1               5                   





<210>  106

<211>  30

<212>  DNA

<213>  Artificial sequence



<220>

<223>  D2 heavy chain CDR1



<400>  106

ggaggcacct tcagcagcta tgctatcagc                                        30





<210>  107

<211>  51

<212>  DNA

<213>  Artificial sequence



<220>

<223>  D2 heavy chain CDR2



<400>  107

ataatcaacc ctagtggtgg tagcacaagc tacgcacaga agttccaggg c                51





<210>  108

<211>  27

<212>  DNA

<213>  Artificial sequence



<220>

<223>  D2 heavy chain CDR3



<400>  108

ggggggccta caggcatctt tgactac                                           27





<210>  109

<211>  215

<212>  PRT

<213>  Artificial sequence



<220>

<223>  D2 Fab light chain



<400>  109



Leu Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 

1               5                   10                  15      





Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 

            20                  25                  30          





Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 

        35                  40                  45              





Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 

    50                  55                  60                  





Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 

65                  70                  75                  80  





Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro 

                85                  90                  95      





Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 

            100                 105                 110         





Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 

        115                 120                 125             





Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Lys 

    130                 135                 140                 





Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 

145                 150                 155                 160 





Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 

                165                 170                 175     





Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 

            180                 185                 190         





Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 

        195                 200                 205             





Ser Phe Asn Arg Gly Glu Cys 

    210                 215 





<210>  110

<211>  645

<212>  DNA

<213>  Artificial sequence



<220>

<223>  D2 Fab light chain



<400>  110

cttgaaattg tgctgactca gtctccagcc accctgtctt tgtctccagg ggaaagagcc       60



accctctcct gcagggccag tcagagtgtt agcagctact tagcctggta ccaacagaaa      120



cctggccagg ctcccaggct cctcatctat gatgcatcca acagggccac tggcatccca      180



gccaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctagag      240



cctgaagatt ttgcagttta ttactgtcag cagcgtagca actggccgct cactttcggc      300



ggagggacca aggtggagat caaacgaact gtggctgcac catctgtctt catcttcccg      360



ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420



tatcccagaa aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480



caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540



acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600



ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645





<210>  111

<211>  247

<212>  PRT

<213>  Artificial sequence



<220>

<223>  D2 Fab heavy chain



<400>  111



Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 

1               5                   10                  15      





Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 

            20                  25                  30          





Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 

        35                  40                  45              





Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 

    50                  55                  60                  





Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 

65                  70                  75                  80  





Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Arg Gly Gly Pro Thr Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr 

            100                 105                 110         





Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 

        115                 120                 125             





Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 

    130                 135                 140                 





Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 

145                 150                 155                 160 





Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 

                165                 170                 175     





Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 

            180                 185                 190         





Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 

        195                 200                 205             





Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ala Ala Ala 

    210                 215                 220                 





His His His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu 

225                 230                 235                 240 





Glu Asp Leu Asn Gly Ala Ala 

                245         





<210>  112

<211>  741

<212>  DNA

<213>  Artificial sequence



<220>

<223>  D2 Fab heavy chain



<400>  112

gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60



tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120



cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180



gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240



atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggg      300



cctacaggca tctttgacta ctggggccag ggcaccctgg tcaccgtctc aagcgcctcc      360



accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420



gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480



tcaggcgccc tgaccagcgg cgtccacacc ttcccggctg tcctacagtc ctcaggactc      540



tactccctca gcagcgtagt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600



tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660



tgtgcggccg cacatcatca tcaccatcac ggggccgcag aacaaaaact catctcagaa      720



gaggatctga atggggccgc a                                                741





<210>  113

<211>  110

<212>  PRT

<213>  Homo sapiens



<400>  113



Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 

1               5                   10                  15      





Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 

            20                  25                  30          





Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 

        35                  40                  45              





Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 

    50                  55                  60                  





Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 

65                  70                  75                  80  





Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 

                85                  90                  95      





Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 

            100                 105                 110 





<210>  114

<211>  86

<212>  PRT

<213>  Homo sapiens



<400>  114



Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 

1               5                   10                  15      





Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 

            20                  25                  30          





Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 

        35                  40                  45              





Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 

    50                  55                  60                  





Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 

65                  70                  75                  80  





Leu Glu Asn Tyr Cys Asn 

                85      





<210>  115

<211>  585

<212>  PRT

<213>  Homo sapiens



<400>  115



Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly 

1               5                   10                  15      





Ser Gly Asp Ser Glu Asn Pro Gly Thr Ala Arg Ala Trp Cys Gln Val 

            20                  25                  30          





Ala Gln Lys Phe Thr Gly Gly Ile Gly Asn Lys Leu Cys Ala Leu Leu 

        35                  40                  45              





Tyr Gly Asp Ala Glu Lys Pro Ala Glu Ser Gly Gly Ser Gln Pro Pro 

    50                  55                  60                  





Arg Ala Ala Ala Arg Lys Ala Ala Cys Ala Cys Asp Gln Lys Pro Cys 

65                  70                  75                  80  





Ser Cys Ser Lys Val Asp Val Asn Tyr Ala Phe Leu His Ala Thr Asp 

                85                  90                  95      





Leu Leu Pro Ala Cys Asp Gly Glu Arg Pro Thr Leu Ala Phe Leu Gln 

            100                 105                 110         





Asp Val Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg 

        115                 120                 125             





Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu Leu Leu Gln Glu 

    130                 135                 140                 





Tyr Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu 

145                 150                 155                 160 





Met His Cys Gln Thr Thr Leu Lys Tyr Ala Ile Lys Thr Gly His Pro 

                165                 170                 175     





Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp Met Val Gly Leu Ala 

            180                 185                 190         





Ala Asp Trp Leu Thr Ser Thr Ala Asn Thr Asn Met Phe Thr Tyr Glu 

        195                 200                 205             





Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr Leu Lys Lys Met 

    210                 215                 220                 





Arg Glu Ile Ile Gly Trp Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser 

225                 230                 235                 240 





Pro Gly Gly Ala Ile Ser Asn Met Tyr Ala Met Met Ile Ala Arg Phe 

                245                 250                 255     





Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg 

            260                 265                 270         





Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys Lys Gly 

        275                 280                 285             





Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Lys Cys 

    290                 295                 300                 





Asp Glu Arg Gly Lys Met Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu 

305                 310                 315                 320 





Glu Ala Lys Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr Ala 

                325                 330                 335     





Gly Thr Thr Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp 

            340                 345                 350         





Ile Cys Lys Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly 

        355                 360                 365             





Gly Gly Leu Leu Met Ser Arg Lys His Lys Trp Lys Leu Ser Gly Val 

    370                 375                 380                 





Glu Arg Ala Asn Ser Val Thr Trp Asn Pro His Lys Met Met Gly Val 

385                 390                 395                 400 





Pro Leu Gln Cys Ser Ala Leu Leu Val Arg Glu Glu Gly Leu Met Gln 

                405                 410                 415     





Asn Cys Asn Gln Met His Ala Ser Tyr Leu Phe Gln Gln Asp Lys His 

            420                 425                 430         





Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln Cys Gly Arg 

        435                 440                 445             





His Val Asp Val Phe Lys Leu Trp Leu Met Trp Arg Ala Lys Gly Thr 

    450                 455                 460                 





Thr Gly Phe Glu Ala His Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr 

465                 470                 475                 480 





Leu Tyr Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe Asp 

                485                 490                 495     





Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp Tyr Ile Pro Pro Ser 

            500                 505                 510         





Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys 

        515                 520                 525             





Val Ala Pro Val Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met 

    530                 535                 540                 





Val Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val 

545                 550                 555                 560 





Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu 

                565                 570                 575     





Glu Ile Glu Arg Leu Gly Gln Asp Leu 

            580                 585 





<210>  116

<211>  566

<212>  PRT

<213>  Homo sapiens



<400>  116



Met Pro Arg Gly Phe Leu Val Lys Arg Thr Lys Arg Thr Gly Gly Leu 

1               5                   10                  15      





Tyr Arg Val Arg Leu Ala Glu Arg Val Phe Pro Leu Leu Gly Pro Gln 

            20                  25                  30          





Gly Ala Pro Pro Phe Leu Glu Glu Ala Pro Ser Ala Ser Leu Pro Gly 

        35                  40                  45              





Ala Glu Arg Ala Thr Pro Pro Thr Arg Glu Glu Pro Gly Lys Gly Leu 

    50                  55                  60                  





Thr Ala Glu Ala Ala Arg Glu Gln Ser Gly Ser Pro Cys Arg Ala Ala 

65                  70                  75                  80  





Gly Val Ser Pro Gly Thr Gly Gly Arg Glu Gly Ala Glu Trp Arg Ala 

                85                  90                  95      





Gly Gly Arg Glu Gly Pro Gly Pro Ser Pro Ser Pro Ser Pro Ser Pro 

            100                 105                 110         





Ala Lys Pro Ala Gly Ala Glu Leu Arg Arg Ala Phe Leu Glu Arg Cys 

        115                 120                 125             





Leu Ser Ser Pro Val Ser Ala Glu Ser Phe Pro Gly Gly Ala Ala Ala 

    130                 135                 140                 





Val Ala Ala Phe Ser Cys Ser Val Ala Pro Ala Ala Ala Pro Thr Pro 

145                 150                 155                 160 





Gly Glu Gln Phe Leu Leu Pro Leu Arg Ala Pro Phe Pro Glu Pro Ala 

                165                 170                 175     





Leu Gln Pro Asp Pro Ala Pro Leu Ser Ala Ala Leu Gln Ser Leu Lys 

            180                 185                 190         





Arg Ala Ala Gly Gly Glu Arg Arg Gly Lys Ala Pro Thr Asp Cys Ala 

        195                 200                 205             





Ser Gly Pro Ala Ala Ala Gly Ile Lys Lys Pro Lys Ala Met Arg Lys 

    210                 215                 220                 





Leu Ser Phe Ala Asp Glu Val Thr Thr Ser Pro Val Leu Gly Leu Lys 

225                 230                 235                 240 





Ile Lys Glu Glu Glu Pro Gly Ala Pro Ser Arg Gly Leu Gly Gly Ser 

                245                 250                 255     





Arg Thr Pro Leu Gly Glu Phe Ile Cys Gln Leu Cys Lys Glu Gln Tyr 

            260                 265                 270         





Ala Asp Pro Phe Ala Leu Ala Gln His Arg Cys Ser Arg Ile Val Arg 

        275                 280                 285             





Val Glu Tyr Arg Cys Pro Glu Cys Asp Lys Val Phe Ser Cys Pro Ala 

    290                 295                 300                 





Asn Leu Ala Ser His Arg Arg Trp His Lys Pro Arg Pro Ala Ala Ala 

305                 310                 315                 320 





Asn Ala Ala Thr Val Ser Ser Ala Asp Gly Lys Pro Pro Ser Ser Ser 

                325                 330                 335     





Ser Ser Ser Ser Arg Asp Ser Gly Ala Ile Ala Ser Phe Leu Ala Glu 

            340                 345                 350         





Gly Lys Glu Asn Ser Arg Ile Glu Arg Thr Ala Asp Gln His Pro Gln 

        355                 360                 365             





Ala Arg Asp Ser Ser Gly Ala Asp Gln His Pro Asp Ser Ala Pro Arg 

    370                 375                 380                 





Gln Gly Leu Gln Val Leu Thr His Pro Glu Pro Pro Leu Pro Gln Gly 

385                 390                 395                 400 





Pro Tyr Thr Glu Gly Val Leu Gly Arg Arg Val Pro Val Pro Gly Ser 

                405                 410                 415     





Thr Ser Gly Gly Arg Gly Ser Glu Ile Phe Val Cys Pro Tyr Cys His 

            420                 425                 430         





Lys Lys Phe Arg Arg Gln Ala Tyr Leu Arg Lys His Leu Ser Thr His 

        435                 440                 445             





Glu Ala Gly Ser Ala Arg Ala Leu Ala Pro Gly Phe Gly Ser Glu Arg 

    450                 455                 460                 





Gly Ala Pro Leu Ala Phe Ala Cys Pro Leu Cys Gly Ala His Phe Pro 

465                 470                 475                 480 





Thr Ala Asp Ile Arg Glu Lys His Arg Leu Trp His Ala Val Arg Glu 

                485                 490                 495     





Glu Leu Leu Leu Pro Ala Leu Ala Gly Ala Pro Pro Glu Thr Ser Gly 

            500                 505                 510         





Pro Ser Gly Pro Ser Asp Gly Ser Ala Gln Gln Ile Phe Ser Cys Lys 

        515                 520                 525             





His Cys Pro Ser Thr Phe Phe Ser Ser Pro Gly Leu Thr Arg His Ile 

    530                 535                 540                 





Asn Lys Cys His Pro Ser Glu Ser Arg Gln Val Leu Leu Leu Gln Met 

545                 550                 555                 560 





Pro Leu Arg Pro Gly Cys 

                565     





<210>  117

<211>  986

<212>  PRT

<213>  Homo sapiens



<400>  117



Met Gly Pro Pro Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro 

1               5                   10                  15      





Pro Arg Val Leu Pro Ala Ala Pro Ser Ser Val Pro Arg Gly Arg Gln 

            20                  25                  30          





Leu Pro Gly Arg Leu Gly Cys Leu Leu Glu Glu Gly Leu Cys Gly Ala 

        35                  40                  45              





Ser Glu Ala Cys Val Asn Asp Gly Val Phe Gly Arg Cys Gln Lys Val 

    50                  55                  60                  





Pro Ala Met Asp Phe Tyr Arg Tyr Glu Val Ser Pro Val Ala Leu Gln 

65                  70                  75                  80  





Arg Leu Arg Val Ala Leu Gln Lys Leu Ser Gly Thr Gly Phe Thr Trp 

                85                  90                  95      





Gln Asp Asp Tyr Thr Gln Tyr Val Met Asp Gln Glu Leu Ala Asp Leu 

            100                 105                 110         





Pro Lys Thr Tyr Leu Arg Arg Pro Glu Ala Ser Ser Pro Ala Arg Pro 

        115                 120                 125             





Ser Lys His Ser Val Gly Ser Glu Arg Arg Tyr Ser Arg Glu Gly Gly 

    130                 135                 140                 





Ala Ala Leu Ala Asn Ala Leu Arg Arg His Leu Pro Phe Leu Glu Ala 

145                 150                 155                 160 





Leu Ser Gln Ala Pro Ala Ser Asp Val Leu Ala Arg Thr His Thr Ala 

                165                 170                 175     





Gln Asp Arg Pro Pro Ala Glu Gly Asp Asp Arg Phe Ser Glu Ser Ile 

            180                 185                 190         





Leu Thr Tyr Val Ala His Thr Ser Ala Leu Thr Tyr Pro Pro Gly Ser 

        195                 200                 205             





Arg Thr Gln Leu Arg Glu Asp Leu Leu Pro Arg Thr Leu Gly Gln Leu 

    210                 215                 220                 





Gln Pro Asp Glu Leu Ser Pro Lys Val Asp Ser Gly Val Asp Arg His 

225                 230                 235                 240 





His Leu Met Ala Ala Leu Ser Ala Tyr Ala Ala Gln Arg Pro Pro Ala 

                245                 250                 255     





Pro Pro Gly Glu Gly Ser Leu Glu Pro Gln Tyr Leu Leu Arg Ala Pro 

            260                 265                 270         





Ser Arg Met Pro Arg Pro Leu Leu Ala Pro Ala Ala Pro Gln Lys Trp 

        275                 280                 285             





Pro Ser Pro Leu Gly Asp Ser Glu Asp Pro Ser Ser Thr Gly Asp Gly 

    290                 295                 300                 





Ala Arg Ile His Thr Leu Leu Lys Asp Leu Gln Arg Gln Pro Ala Glu 

305                 310                 315                 320 





Val Arg Gly Leu Ser Gly Leu Glu Leu Asp Gly Met Ala Glu Leu Met 

                325                 330                 335     





Ala Gly Leu Met Gln Gly Val Asp His Gly Val Ala Arg Gly Ser Pro 

            340                 345                 350         





Gly Arg Ala Ala Leu Gly Glu Ser Gly Glu Gln Ala Asp Gly Pro Lys 

        355                 360                 365             





Ala Thr Leu Arg Gly Asp Ser Phe Pro Asp Asp Gly Val Gln Asp Asp 

    370                 375                 380                 





Asp Asp Arg Leu Tyr Gln Glu Val His Arg Leu Ser Ala Thr Leu Gly 

385                 390                 395                 400 





Gly Leu Leu Gln Asp His Gly Ser Arg Leu Leu Pro Gly Ala Leu Pro 

                405                 410                 415     





Phe Ala Arg Pro Leu Asp Met Glu Arg Lys Lys Ser Glu His Pro Glu 

            420                 425                 430         





Ser Ser Leu Ser Ser Glu Glu Glu Thr Ala Gly Val Glu Asn Val Lys 

        435                 440                 445             





Ser Gln Thr Tyr Ser Lys Asp Leu Leu Gly Gln Gln Pro His Ser Glu 

    450                 455                 460                 





Pro Gly Ala Ala Ala Phe Gly Glu Leu Gln Asn Gln Met Pro Gly Pro 

465                 470                 475                 480 





Ser Lys Glu Glu Gln Ser Leu Pro Ala Gly Ala Gln Glu Ala Leu Ser 

                485                 490                 495     





Asp Gly Leu Gln Leu Glu Val Gln Pro Ser Glu Glu Glu Ala Arg Gly 

            500                 505                 510         





Tyr Ile Val Thr Asp Arg Glu Val Leu Gly Pro Ala Val Thr Phe Lys 

        515                 520                 525             





Val Ser Ala Asn Val Gln Asn Val Thr Thr Glu Asp Val Glu Lys Ala 

    530                 535                 540                 





Thr Val Asp Asn Lys Asp Lys Leu Glu Glu Thr Ser Gly Leu Lys Ile 

545                 550                 555                 560 





Leu Gln Thr Gly Val Gly Ser Lys Ser Lys Leu Lys Phe Leu Pro Pro 

                565                 570                 575     





Gln Ala Glu Gln Glu Asp Ser Thr Lys Phe Ile Ala Leu Thr Leu Val 

            580                 585                 590         





Ser Leu Ala Cys Ile Leu Gly Val Leu Leu Ala Ser Gly Leu Ile Tyr 

        595                 600                 605             





Cys Leu Arg His Ser Ser Gln His Arg Leu Lys Glu Lys Leu Ser Gly 

    610                 615                 620                 





Leu Gly Gly Asp Pro Gly Ala Asp Ala Thr Ala Ala Tyr Gln Glu Leu 

625                 630                 635                 640 





Cys Arg Gln Arg Met Ala Thr Arg Pro Pro Asp Arg Pro Glu Gly Pro 

                645                 650                 655     





His Thr Ser Arg Ile Ser Ser Val Ser Ser Gln Phe Ser Asp Gly Pro 

            660                 665                 670         





Ile Pro Ser Pro Ser Ala Arg Ser Ser Ala Ser Ser Trp Ser Glu Glu 

        675                 680                 685             





Pro Val Gln Ser Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ser 

    690                 695                 700                 





Tyr Met Glu Asp His Leu Lys Asn Lys Asn Arg Leu Glu Lys Glu Trp 

705                 710                 715                 720 





Glu Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn Ser Ser Phe Val Ala 

                725                 730                 735     





Gln Arg Glu Glu Asn Val Pro Lys Asn Arg Ser Leu Ala Val Leu Thr 

            740                 745                 750         





Tyr Asp His Ser Arg Val Leu Leu Lys Ala Glu Asn Ser His Ser His 

        755                 760                 765             





Ser Asp Tyr Ile Asn Ala Ser Pro Ile Met Asp His Asp Pro Arg Asn 

    770                 775                 780                 





Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Pro Ala Thr Val Ala Asp 

785                 790                 795                 800 





Phe Trp Gln Met Val Trp Glu Ser Gly Cys Val Val Ile Val Met Leu 

                805                 810                 815     





Thr Pro Leu Ala Glu Asn Gly Val Arg Gln Cys Tyr His Tyr Trp Pro 

            820                 825                 830         





Asp Glu Gly Ser Asn Leu Tyr His Ile Tyr Glu Val Asn Leu Val Ser 

        835                 840                 845             





Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys 

    850                 855                 860                 





Asn Leu Gln Thr Asn Glu Thr Arg Thr Val Thr Gln Phe His Phe Leu 

865                 870                 875                 880 





Ser Trp Tyr Asp Arg Gly Val Pro Ser Ser Ser Arg Ser Leu Leu Asp 

                885                 890                 895     





Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro Ile 

            900                 905                 910         





Ile Val His Cys Ser Asp Gly Ala Gly Arg Ser Gly Thr Tyr Val Leu 

        915                 920                 925             





Ile Asp Met Val Leu Asn Lys Met Ala Lys Gly Ala Lys Glu Ile Asp 

    930                 935                 940                 





Ile Ala Ala Thr Leu Glu His Leu Arg Asp Gln Arg Pro Gly Met Val 

945                 950                 955                 960 





Gln Thr Lys Glu Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu 

                965                 970                 975     





Val Asn Ala Ile Leu Lys Ala Leu Pro Gln 

            980                 985     





<210>  118

<211>  355

<212>  PRT

<213>  Homo sapiens



<400>  118



Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 

1               5                   10                  15      





Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 

            20                  25                  30          





Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 

        35                  40                  45              





Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 

    50                  55                  60                  





Asp Trp Leu Asn Leu Ile Phe Lys Trp Ile Leu Phe Gly His Arg Pro 

65                  70                  75                  80  





Tyr Trp Trp Val Gln Glu Thr Gln Ile Tyr Pro Asn His Ser Ser Pro 

                85                  90                  95      





Cys Leu Glu Gln Phe Pro Thr Thr Cys Glu Thr Gly Pro Gly Ser Pro 

            100                 105                 110         





Ser Gly His Ala Met Gly Ala Ser Cys Val Trp Tyr Val Met Val Thr 

        115                 120                 125             





Ala Ala Leu Ser His Thr Val Cys Gly Met Asp Lys Phe Ser Ile Thr 

    130                 135                 140                 





Leu His Arg Leu Thr Trp Ser Phe Leu Trp Ser Val Phe Trp Leu Ile 

145                 150                 155                 160 





Gln Ile Ser Val Cys Ile Ser Arg Val Phe Ile Ala Thr His Phe Pro 

                165                 170                 175     





His Gln Val Ile Leu Gly Val Ile Gly Gly Met Leu Val Ala Glu Ala 

            180                 185                 190         





Phe Glu His Thr Pro Gly Ile Gln Thr Ala Ser Leu Gly Thr Tyr Leu 

        195                 200                 205             





Lys Thr Asn Leu Phe Leu Phe Leu Phe Ala Val Gly Phe Tyr Leu Leu 

    210                 215                 220                 





Leu Arg Val Leu Asn Ile Asp Leu Leu Trp Ser Val Pro Ile Ala Lys 

225                 230                 235                 240 





Lys Trp Cys Ala Asn Pro Asp Trp Ile His Ile Asp Thr Thr Pro Phe 

                245                 250                 255     





Ala Gly Leu Val Arg Asn Leu Gly Val Leu Phe Gly Leu Gly Phe Ala 

            260                 265                 270         





Ile Asn Ser Glu Met Phe Leu Leu Ser Cys Arg Gly Gly Asn Asn Tyr 

        275                 280                 285             





Thr Leu Ser Phe Arg Leu Leu Cys Ala Leu Thr Ser Leu Thr Ile Leu 

    290                 295                 300                 





Gln Leu Tyr His Phe Leu Gln Ile Pro Thr His Glu Glu His Leu Phe 

305                 310                 315                 320 





Tyr Val Leu Ser Phe Cys Lys Ser Ala Ser Ile Pro Leu Thr Val Val 

                325                 330                 335     





Ala Phe Ile Pro Tyr Ser Val His Met Leu Met Lys Gln Ser Gly Lys 

            340                 345                 350         





Lys Ser Gln 

        355 





<210>  119

<211>  154

<212>  PRT

<213>  Homo sapiens



<400>  119



Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 

1               5                   10                  15      





Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 

            20                  25                  30          





Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 

        35                  40                  45              





Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 

    50                  55                  60                  





Asp Trp Leu Asn Leu Ile Phe Lys Trp Ile Leu Phe Gly His Arg Pro 

65                  70                  75                  80  





Tyr Trp Trp Val Gln Glu Thr Gln Ile Tyr Pro Asn His Ser Ser Pro 

                85                  90                  95      





Cys Leu Glu Gln Phe Pro Thr Thr Cys Glu Thr Gly Pro Gly Ser Pro 

            100                 105                 110         





Ser Gly His Ala Met Gly Ala Ser Cys Val Trp Tyr Val Met Val Thr 

        115                 120                 125             





Ala Ala Leu Ser His Thr Val Cys Gly Met Asp Lys Phe Ser Ile Thr 

    130                 135                 140                 





Leu His Arg His Ala Gly Gly Arg Gly Leu 

145                 150                 





<210>  120

<211>  457

<212>  PRT

<213>  Homo sapiens



<400>  120



Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 

1               5                   10                  15      





Thr Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Thr Glu Val 

            20                  25                  30          





Met Lys Cys Ile Val Glu Val Ile Ser Asp Thr Leu Ser Lys Pro Ser 

        35                  40                  45              





Pro Met Pro Val Ser Gln Glu Cys Phe Glu Thr Leu Arg Gly Asp Glu 

    50                  55                  60                  





Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 

65                  70                  75                  80  





Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala His Gln Gln Lys Lys 

                85                  90                  95      





His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser 

            100                 105                 110         





Ser Gln Ala Glu Leu Lys Glu Ala Val Glu Glu Pro Ser Ser Lys Asp 

        115                 120                 125             





Val Met Glu Lys Arg Glu Asp Ser Lys Glu Ala Glu Lys Ser Gly Glu 

    130                 135                 140                 





Ala Thr Asp Gly Ala Arg Pro Gln Ala Leu Pro Glu Pro Met Gln Glu 

145                 150                 155                 160 





Ser Lys Ala Glu Gly Asn Asn Gln Ala Pro Gly Glu Glu Glu Glu Glu 

                165                 170                 175     





Glu Glu Glu Ala Thr Asn Thr His Pro Pro Ala Ser Leu Pro Ser Gln 

            180                 185                 190         





Lys Tyr Pro Gly Pro Gln Ala Glu Gly Asp Ser Glu Gly Leu Ser Gln 

        195                 200                 205             





Gly Leu Val Asp Arg Glu Lys Gly Leu Ser Ala Glu Pro Gly Trp Gln 

    210                 215                 220                 





Ala Lys Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Ala Gly 

225                 230                 235                 240 





Glu Glu Ala Val Pro Glu Glu Glu Gly Pro Thr Val Val Leu Asn Pro 

                245                 250                 255     





His Pro Ser Leu Gly Tyr Lys Glu Ile Arg Lys Gly Glu Ser Arg Ser 

            260                 265                 270         





Glu Ala Leu Ala Val Asp Gly Ala Gly Lys Pro Gly Ala Glu Glu Ala 

        275                 280                 285             





Gln Asp Pro Glu Gly Lys Gly Glu Gln Glu His Ser Gln Gln Lys Glu 

    290                 295                 300                 





Glu Glu Glu Glu Met Ala Val Val Pro Gln Gly Leu Phe Arg Gly Gly 

305                 310                 315                 320 





Lys Ser Gly Glu Leu Glu Gln Glu Glu Glu Arg Leu Ser Lys Glu Trp 

                325                 330                 335     





Glu Asp Ser Lys Arg Trp Ser Lys Met Asp Gln Leu Ala Lys Glu Leu 

            340                 345                 350         





Thr Ala Glu Lys Arg Leu Glu Gly Gln Glu Glu Glu Glu Asp Asn Arg 

        355                 360                 365             





Asp Ser Ser Met Lys Leu Ser Phe Arg Ala Arg Ala Tyr Gly Phe Arg 

    370                 375                 380                 





Gly Pro Gly Pro Gln Leu Arg Arg Gly Trp Arg Pro Ser Ser Arg Glu 

385                 390                 395                 400 





Asp Ser Leu Glu Ala Gly Leu Pro Leu Gln Val Arg Gly Tyr Pro Glu 

                405                 410                 415     





Glu Lys Lys Glu Glu Glu Gly Ser Ala Asn Arg Arg Pro Glu Asp Gln 

            420                 425                 430         





Glu Leu Glu Ser Leu Ser Ala Ile Glu Ala Glu Leu Glu Lys Val Ala 

        435                 440                 445             





His Gln Leu Gln Ala Leu Arg Arg Gly 

    450                 455         





<210>  121

<211>  369

<212>  PRT

<213>  Homo sapiens



<400>  121



Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys 

1               5                   10                  15      





Met Tyr Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val 

            20                  25                  30          





Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly 

        35                  40                  45              





Gly Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala 

    50                  55                  60                  





Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Ala Ile 

65                  70                  75                  80  





Cys Phe Ile Phe Met Ile Ala Glu Val Val Gly Gly His Ile Ala Gly 

                85                  90                  95      





Ser Leu Ala Val Val Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr 

            100                 105                 110         





Ser Phe Leu Leu Ser Leu Phe Ser Leu Trp Leu Ser Ser Lys Pro Pro 

        115                 120                 125             





Ser Lys Arg Leu Thr Phe Gly Trp His Arg Ala Glu Ile Leu Gly Ala 

    130                 135                 140                 





Leu Leu Ser Ile Leu Cys Ile Trp Val Val Thr Gly Val Leu Val Tyr 

145                 150                 155                 160 





Leu Ala Cys Glu Arg Leu Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Thr 

                165                 170                 175     





Val Met Ile Ile Val Ser Ser Cys Ala Val Ala Ala Asn Ile Val Leu 

            180                 185                 190         





Thr Val Val Leu His Gln Arg Cys Leu Gly His Asn His Lys Glu Val 

        195                 200                 205             





Gln Ala Asn Ala Ser Val Arg Ala Ala Phe Val His Ala Leu Gly Asp 

    210                 215                 220                 





Leu Phe Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile Ile Tyr Phe 

225                 230                 235                 240 





Lys Pro Glu Tyr Lys Ile Ala Asp Pro Ile Cys Thr Phe Ile Phe Ser 

                245                 250                 255     





Ile Leu Val Leu Ala Ser Thr Ile Thr Ile Leu Lys Asp Phe Ser Ile 

            260                 265                 270         





Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser Gly Val Lys 

        275                 280                 285             





Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val His Ser Leu His 

    290                 295                 300                 





Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala 

305                 310                 315                 320 





Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys 

                325                 330                 335     





Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu 

            340                 345                 350         





Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys 

        355                 360                 365             





Asp 

    





<210>  122

<211>  573

<212>  PRT

<213>  Homo sapiens



<400>  122



Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 

1               5                   10                  15      





Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 

            20                  25                  30          





Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 

        35                  40                  45              





Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 

    50                  55                  60                  





Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 

65                  70                  75                  80  





Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 

                85                  90                  95      





Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 

            100                 105                 110         





Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 

        115                 120                 125             





Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 

    130                 135                 140                 





Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 

145                 150                 155                 160 





Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 

                165                 170                 175     





Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 

            180                 185                 190         





Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 

        195                 200                 205             





Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 

    210                 215                 220                 





Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 

225                 230                 235                 240 





Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 

                245                 250                 255     





Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 

            260                 265                 270         





Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 

        275                 280                 285             





Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 

    290                 295                 300                 





Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 

305                 310                 315                 320 





Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 

                325                 330                 335     





Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 

            340                 345                 350         





Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 

        355                 360                 365             





Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 

    370                 375                 380                 





Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 

385                 390                 395                 400 





Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 

                405                 410                 415     





Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 

            420                 425                 430         





Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 

        435                 440                 445             





Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 

    450                 455                 460                 





Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 

465                 470                 475                 480 





Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 

                485                 490                 495     





Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 

            500                 505                 510         





Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 

        515                 520                 525             





Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 

    530                 535                 540                 





Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 

545                 550                 555                 560 





Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 

                565                 570             





<210>  123

<211>  641

<212>  PRT

<213>  Homo sapiens



<400>  123



Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 

1               5                   10                  15      





Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 

            20                  25                  30          





Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 

        35                  40                  45              





Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 

    50                  55                  60                  





Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 

65                  70                  75                  80  





Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 

                85                  90                  95      





Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 

            100                 105                 110         





Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 

        115                 120                 125             





Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 

    130                 135                 140                 





Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 

145                 150                 155                 160 





Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 

                165                 170                 175     





Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 

            180                 185                 190         





Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 

        195                 200                 205             





Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 

    210                 215                 220                 





Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 

225                 230                 235                 240 





Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 

                245                 250                 255     





Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 

            260                 265                 270         





Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 

        275                 280                 285             





Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 

    290                 295                 300                 





Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 

305                 310                 315                 320 





Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 

                325                 330                 335     





Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 

            340                 345                 350         





Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 

        355                 360                 365             





Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 

    370                 375                 380                 





Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 

385                 390                 395                 400 





Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 

                405                 410                 415     





Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 

            420                 425                 430         





Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 

        435                 440                 445             





Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 

    450                 455                 460                 





Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 

465                 470                 475                 480 





Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 

                485                 490                 495     





Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 

            500                 505                 510         





Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 

        515                 520                 525             





Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 

    530                 535                 540                 





Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 

545                 550                 555                 560 





Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 

                565                 570                 575     





Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 

            580                 585                 590         





Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 

        595                 600                 605             





Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 

    610                 615                 620                 





Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 

625                 630                 635                 640 





Asp 

    





<210>  124

<211>  641

<212>  PRT

<213>  Homo sapiens



<400>  124



Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 

1               5                   10                  15      





Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 

            20                  25                  30          





Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 

        35                  40                  45              





Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 

    50                  55                  60                  





Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 

65                  70                  75                  80  





Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 

                85                  90                  95      





Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 

            100                 105                 110         





Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 

        115                 120                 125             





Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 

    130                 135                 140                 





Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 

145                 150                 155                 160 





Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 

                165                 170                 175     





Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 

            180                 185                 190         





Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 

        195                 200                 205             





Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 

    210                 215                 220                 





Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 

225                 230                 235                 240 





Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 

                245                 250                 255     





Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 

            260                 265                 270         





Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 

        275                 280                 285             





Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 

    290                 295                 300                 





Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 

305                 310                 315                 320 





Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 

                325                 330                 335     





Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 

            340                 345                 350         





Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 

        355                 360                 365             





Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 

    370                 375                 380                 





Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 

385                 390                 395                 400 





Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 

                405                 410                 415     





Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 

            420                 425                 430         





Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 

        435                 440                 445             





Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 

    450                 455                 460                 





Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 

465                 470                 475                 480 





Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 

                485                 490                 495     





Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 

            500                 505                 510         





Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 

        515                 520                 525             





Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 

    530                 535                 540                 





Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 

545                 550                 555                 560 





Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 

                565                 570                 575     





Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 

            580                 585                 590         





Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 

        595                 600                 605             





Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 

    610                 615                 620                 





Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 

625                 630                 635                 640 





Asp 

    





<210>  125

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  GAD556-565 peptide



<400>  125



Phe Phe Arg Met Val Ile Ser Asn Pro Ala 

1               5                   10  





<210>  126

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Diabetes-associated autoantigenic peptide



<400>  126



Met Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 

1               5                   10              





<210>  127

<211>  197

<212>  PRT

<213>  Homo sapiens



<400>  127



Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 

1               5                   10                  15      





Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 

            20                  25                  30          





His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 

        35                  40                  45              





Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 

    50                  55                  60                  





Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 

65                  70                  75                  80  





Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 

                85                  90                  95      





Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 

            100                 105                 110         





Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 

        115                 120                 125             





Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly 

    130                 135                 140                 





Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp 

145                 150                 155                 160 





Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 

                165                 170                 175     





Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser 

            180                 185                 190         





Pro Met Ala Arg Arg 

        195         





<210>  128

<211>  277

<212>  PRT

<213>  Homo sapiens



<400>  128



Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 

1               5                   10                  15      





Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 

            20                  25                  30          





Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 

        35                  40                  45              





Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 

    50                  55                  60                  





Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 

65                  70                  75                  80  





Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 

                85                  90                  95      





Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 

            100                 105                 110         





Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 

        115                 120                 125             





Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 

    130                 135                 140                 





Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 

145                 150                 155                 160 





Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 

                165                 170                 175     





Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 

            180                 185                 190         





Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 

        195                 200                 205             





Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 

    210                 215                 220                 





Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 

225                 230                 235                 240 





Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 

                245                 250                 255     





Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 

            260                 265                 270         





Arg Gly Thr Lys Phe 

        275         





<210>  129

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  129



Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu 

1               5                   10                  15      





Tyr Arg Asn Gly Lys 

            20      





<210>  130

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  MHC class II-restricted MBP-85-99 antigenic peptide



<400>  130



Met Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 

1               5                   10                  15      





<210>  131

<211>  280

<212>  PRT

<213>  Aegilops tauschii



<400>  131



Met Lys Thr Phe Leu Ile Leu Ala Leu Leu Ala Ile Val Ala Thr Thr 

1               5                   10                  15      





Ala Thr Ile Ala Val Arg Val Pro Val Pro Gln Leu Gln Pro Gln Asn 

            20                  25                  30          





Pro Ser Gln Gln Gln Pro Gln Glu Gln Val Pro Leu Val Gln Gln Gln 

        35                  40                  45              





Gln Phe Pro Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro 

    50                  55                  60                  





Gln Pro Gln Pro Phe Pro Ser Gln Gln Pro Tyr Leu Gln Leu Gln Pro 

65                  70                  75                  80  





Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Pro Phe Arg Pro 

                85                  90                  95      





Gln Gln Pro Tyr Pro Gln Pro Gln Pro Gln Tyr Ser Gln Pro Gln Gln 

            100                 105                 110         





Pro Ile Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 

        115                 120                 125             





Gln Gln Ile Leu Gln Gln Ile Leu Gln Gln Gln Leu Ile Pro Cys Arg 

    130                 135                 140                 





Asp Val Val Leu Gln Gln His Asn Val Ala His Gly Ser Ser Gln Val 

145                 150                 155                 160 





Leu Gln Gln Ser Thr Tyr Gln Leu Val Gln Gln Leu Cys Cys Gln Gln 

                165                 170                 175     





Leu Trp Gln Ile Pro Glu Gln Ser Arg Cys Gln Ala Ile His Asn Val 

            180                 185                 190         





Val His Ala Ile Ile Leu His Gln Gln Gln Gln Gln Pro Leu Ser Gln 

        195                 200                 205             





Val Ser Phe Gln Gln Pro Gln Gln Gln Tyr Pro Ser Gly Gln Gly Ser 

    210                 215                 220                 





Phe Gln Pro Ser Gln Gln Asn Pro Gln Ala Gln Gly Ser Val Gln Pro 

225                 230                 235                 240 





Gln Gln Leu Pro Gln Phe Glu Glu Ile Arg Asn Leu Ala Leu Glu Thr 

                245                 250                 255     





Leu Pro Ala Met Cys Asn Val Tyr Ile Pro Pro Tyr Cys Thr Ile Ala 

            260                 265                 270         





Pro Gly Gly Ile Phe Gly Thr Asn 

        275                 280 





<210>  132

<211>  1487

<212>  PRT

<213>  Homo sapiens



<400>  132



Met Ile Arg Leu Gly Ala Pro Gln Thr Leu Val Leu Leu Thr Leu Leu 

1               5                   10                  15      





Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Gln Glu Ala Gly 

            20                  25                  30          





Ser Cys Val Gln Asp Gly Gln Arg Tyr Asn Asp Lys Asp Val Trp Lys 

        35                  40                  45              





Pro Glu Pro Cys Arg Ile Cys Val Cys Asp Thr Gly Thr Val Leu Cys 

    50                  55                  60                  





Asp Asp Ile Ile Cys Glu Asp Val Lys Asp Cys Leu Ser Pro Glu Ile 

65                  70                  75                  80  





Pro Phe Gly Glu Cys Cys Pro Ile Cys Pro Thr Asp Leu Ala Thr Ala 

                85                  90                  95      





Ser Gly Gln Pro Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile 

            100                 105                 110         





Lys Asp Ile Val Gly Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala 

        115                 120                 125             





Gly Glu Gln Gly Pro Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly 

    130                 135                 140                 





Ala Pro Gly Pro Arg Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn 

145                 150                 155                 160 





Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly 

                165                 170                 175     





Gly Asn Phe Ala Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly 

            180                 185                 190         





Gly Ala Gln Leu Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro 

        195                 200                 205             





Arg Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 

    210                 215                 220                 





Gly Asn Pro Gly Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly 

225                 230                 235                 240 





Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu 

                245                 250                 255     





Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln 

            260                 265                 270         





Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly 

        275                 280                 285             





His Arg Gly Tyr Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala 

    290                 295                 300                 





Pro Gly Val Lys Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro 

305                 310                 315                 320 





Gly Pro Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly 

                325                 330                 335     





Pro Ala Gly Ala Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro 

            340                 345                 350         





Ala Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro 

        355                 360                 365             





Gly Ala Pro Gly Ala Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly 

    370                 375                 380                 





Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser 

385                 390                 395                 400 





Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro 

                405                 410                 415     





Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly 

            420                 425                 430         





Phe Pro Gly Pro Arg Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro 

        435                 440                 445             





Leu Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys 

    450                 455                 460                 





Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly 

465                 470                 475                 480 





Ala Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu 

                485                 490                 495     





Pro Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro 

            500                 505                 510         





Gly Asn Arg Gly Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly 

        515                 520                 525             





Ala Pro Gly Glu Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala 

    530                 535                 540                 





Asn Gly Asp Pro Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg 

545                 550                 555                 560 





Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly 

                565                 570                 575     





Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 

            580                 585                 590         





Gln Gly Ala Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys 

        595                 600                 605             





Gly Ala Asn Gly Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly 

    610                 615                 620                 





Ala Pro Gly Leu Arg Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala 

625                 630                 635                 640 





Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln 

                645                 650                 655     





Gly Ala Pro Gly Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly 

            660                 665                 670         





Pro Pro Gly Glu Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu 

        675                 680                 685             





Ala Gly Ala Pro Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro 

    690                 695                 700                 





Gly Glu Arg Gly Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly 

705                 710                 715                 720 





Leu Pro Gly Thr Pro Gly Thr Asp Gly Pro Lys Gly Ala Ser Gly Pro 

                725                 730                 735     





Ala Gly Pro Pro Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro 

            740                 745                 750         





Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly 

        755                 760                 765             





Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly 

    770                 775                 780                 





Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn 

785                 790                 795                 800 





Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly 

                805                 810                 815     





Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro 

            820                 825                 830         





Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys 

        835                 840                 845             





Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly 

    850                 855                 860                 





Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val 

865                 870                 875                 880 





Thr Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr 

                885                 890                 895     





Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly 

            900                 905                 910         





Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro 

        915                 920                 925             





Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 

    930                 935                 940                 





Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 

945                 950                 955                 960 





Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu 

                965                 970                 975     





Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg 

            980                 985                 990         





Gly Phe Pro Gly Leu Pro Gly Pro  Ser Gly Glu Pro Gly  Lys Gln Gly 

        995                 1000                 1005             





Ala Pro  Gly Ala Ser Gly Asp  Arg Gly Pro Pro Gly  Pro Val Gly 

    1010                 1015                 1020             





Pro Pro  Gly Leu Thr Gly Pro  Ala Gly Glu Pro Gly  Arg Glu Gly 

    1025                 1030                 1035             





Ser Pro  Gly Ala Asp Gly Pro  Pro Gly Arg Asp Gly  Ala Ala Gly 

    1040                 1045                 1050             





Val Lys  Gly Asp Arg Gly Glu  Thr Gly Ala Val Gly  Ala Pro Gly 

    1055                 1060                 1065             





Ala Pro  Gly Pro Pro Gly Ser  Pro Gly Pro Ala Gly  Pro Thr Gly 

    1070                 1075                 1080             





Lys Gln  Gly Asp Arg Gly Glu  Ala Gly Ala Gln Gly  Pro Met Gly 

    1085                 1090                 1095             





Pro Ser  Gly Pro Ala Gly Ala  Arg Gly Ile Gln Gly  Pro Gln Gly 

    1100                 1105                 1110             





Pro Arg  Gly Asp Lys Gly Glu  Ala Gly Glu Pro Gly  Glu Arg Gly 

    1115                 1120                 1125             





Leu Lys  Gly His Arg Gly Phe  Thr Gly Leu Gln Gly  Leu Pro Gly 

    1130                 1135                 1140             





Pro Pro  Gly Pro Ser Gly Asp  Gln Gly Ala Ser Gly  Pro Ala Gly 

    1145                 1150                 1155             





Pro Ser  Gly Pro Arg Gly Pro  Pro Gly Pro Val Gly  Pro Ser Gly 

    1160                 1165                 1170             





Lys Asp  Gly Ala Asn Gly Ile  Pro Gly Pro Ile Gly  Pro Pro Gly 

    1175                 1180                 1185             





Pro Arg  Gly Arg Ser Gly Glu  Thr Gly Pro Ala Gly  Pro Pro Gly 

    1190                 1195                 1200             





Asn Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Gly Ile 

    1205                 1210                 1215             





Asp Met  Ser Ala Phe Ala Gly  Leu Gly Pro Arg Glu  Lys Gly Pro 

    1220                 1225                 1230             





Asp Pro  Leu Gln Tyr Met Arg  Ala Asp Gln Ala Ala  Gly Gly Leu 

    1235                 1240                 1245             





Arg Gln  His Asp Ala Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 

    1250                 1255                 1260             





Asn Gln  Ile Glu Ser Ile Arg  Ser Pro Glu Gly Ser  Arg Lys Asn 

    1265                 1270                 1275             





Pro Ala  Arg Thr Cys Arg Asp  Leu Lys Leu Cys His  Pro Glu Trp 

    1280                 1285                 1290             





Lys Ser  Gly Asp Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Leu 

    1295                 1300                 1305             





Asp Ala  Met Lys Val Phe Cys  Asn Met Glu Thr Gly  Glu Thr Cys 

    1310                 1315                 1320             





Val Tyr  Pro Asn Pro Ala Asn  Val Pro Lys Lys Asn  Trp Trp Ser 

    1325                 1330                 1335             





Ser Lys  Ser Lys Glu Lys Lys  His Ile Trp Phe Gly  Glu Thr Ile 

    1340                 1345                 1350             





Asn Gly  Gly Phe His Phe Ser  Tyr Gly Asp Asp Asn  Leu Ala Pro 

    1355                 1360                 1365             





Asn Thr  Ala Asn Val Gln Met  Thr Phe Leu Arg Leu  Leu Ser Thr 

    1370                 1375                 1380             





Glu Gly  Ser Gln Asn Ile Thr  Tyr His Cys Lys Asn  Ser Ile Ala 

    1385                 1390                 1395             





Tyr Leu  Asp Glu Ala Ala Gly  Asn Leu Lys Lys Ala  Leu Leu Ile 

    1400                 1405                 1410             





Gln Gly  Ser Asn Asp Val Glu  Ile Arg Ala Glu Gly  Asn Ser Arg 

    1415                 1420                 1425             





Phe Thr  Tyr Thr Ala Leu Lys  Asp Gly Cys Thr Lys  His Thr Gly 

    1430                 1435                 1440             





Lys Trp  Gly Lys Thr Val Ile  Glu Tyr Arg Ser Gln  Lys Thr Ser 

    1445                 1450                 1455             





Arg Leu  Pro Ile Ile Asp Ile  Ala Pro Met Asp Ile  Gly Gly Pro 

    1460                 1465                 1470             





Glu Gln  Glu Phe Gly Val Asp  Ile Gly Pro Val Cys  Phe Leu 

    1475                 1480                 1485         





<210>  133

<211>  998

<212>  PRT

<213>  Homo sapiens



<400>  133



Met Gly Pro Pro Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro 

1               5                   10                  15      





Pro Arg Val Leu Pro Ala Ala Pro Ser Ser Val Pro Arg Gly Arg Gln 

            20                  25                  30          





Leu Pro Gly Arg Leu Asp Gly Val Phe Gly Arg Cys Gln Lys Val Pro 

        35                  40                  45              





Ala Met Asp Phe Tyr Arg Tyr Glu Val Ser Pro Val Ala Leu Gln Arg 

    50                  55                  60                  





Leu Arg Val Ala Leu Gln Lys Leu Ser Gly Thr Gly Phe Thr Trp Gln 

65                  70                  75                  80  





Asp Asp Tyr Thr Gln Tyr Val Met Asp Gln Glu Leu Ala Asp Leu Pro 

                85                  90                  95      





Lys Thr Tyr Leu Arg Arg Pro Glu Ala Ser Ser Pro Ala Arg Pro Ser 

            100                 105                 110         





Lys His Ser Val Gly Ser Glu Arg Arg Tyr Ser Arg Glu Gly Gly Ala 

        115                 120                 125             





Ala Leu Ala Asn Ala Leu Arg Arg His Leu Pro Phe Leu Glu Ala Leu 

    130                 135                 140                 





Ser Gln Ala Pro Ala Ser Asp Val Leu Ala Arg Thr His Thr Ala Gln 

145                 150                 155                 160 





Asp Arg Pro Pro Ala Glu Gly Asp Asp Arg Phe Ser Glu Ser Ile Leu 

                165                 170                 175     





Thr Tyr Val Ala His Thr Ser Ala Leu Thr Tyr Pro Pro Gly Ser Arg 

            180                 185                 190         





Thr Gln Leu Arg Glu Asp Leu Leu Pro Arg Thr Leu Gly Gln Leu Gln 

        195                 200                 205             





Pro Asp Glu Leu Ser Pro Lys Val Asp Ser Gly Val Asp Arg His His 

    210                 215                 220                 





Leu Met Ala Ala Leu Ser Ala Tyr Ala Ala Gln Arg Pro Pro Ala Pro 

225                 230                 235                 240 





Pro Gly Glu Gly Ser Leu Glu Pro Gln Tyr Leu Leu Arg Ala Pro Ser 

                245                 250                 255     





Arg Met Pro Arg Pro Leu Leu Ala Pro Ala Ala Pro Gln Lys Trp Pro 

            260                 265                 270         





Ser Pro Leu Gly Asp Ser Glu Asp Pro Ser Ser Thr Gly Asp Gly Ala 

        275                 280                 285             





Arg Ile His Thr Leu Leu Lys Asp Leu Gln Arg Gln Pro Ala Glu Val 

    290                 295                 300                 





Arg Gly Leu Ser Gly Leu Glu Leu Asp Gly Met Ala Glu Leu Met Ala 

305                 310                 315                 320 





Gly Leu Met Gln Gly Val Asp His Gly Val Ala Arg Gly Ser Pro Gly 

                325                 330                 335     





Arg Ala Ala Leu Gly Glu Ser Gly Glu Gln Ala Asp Gly Pro Lys Ala 

            340                 345                 350         





Thr Leu Arg Gly Asp Ser Phe Pro Asp Asp Gly Val Gln Asp Asp Asp 

        355                 360                 365             





Asp Arg Leu Tyr Gln Glu Val His Arg Leu Ser Ala Thr Leu Gly Gly 

    370                 375                 380                 





Leu Leu Gln Asp His Gly Ser Arg Leu Leu Pro Gly Ala Leu Pro Phe 

385                 390                 395                 400 





Ala Arg Pro Leu Asp Met Glu Arg Lys Lys Ser Glu His Pro Glu Ser 

                405                 410                 415     





Ser Leu Ser Ser Glu Glu Glu Thr Ala Gly Val Glu Asn Val Lys Ser 

            420                 425                 430         





Gln Thr Tyr Ser Lys Asp Leu Leu Gly Gln Gln Pro His Ser Glu Pro 

        435                 440                 445             





Gly Ala Ala Ala Phe Gly Glu Leu Gln Asn Gln Met Pro Gly Pro Ser 

    450                 455                 460                 





Lys Glu Glu Gln Ser Leu Pro Ala Gly Ala Gln Glu Ala Leu Ser Asp 

465                 470                 475                 480 





Gly Leu Gln Leu Glu Val Gln Pro Ser Glu Glu Glu Ala Arg Gly Tyr 

                485                 490                 495     





Ile Val Thr Asp Arg Asp Pro Leu Arg Pro Glu Glu Gly Arg Arg Leu 

            500                 505                 510         





Val Glu Asp Val Ala Arg Leu Leu Gln Val Pro Ser Ser Ala Phe Ala 

        515                 520                 525             





Asp Val Glu Val Leu Gly Pro Ala Val Thr Phe Lys Val Ser Ala Asn 

    530                 535                 540                 





Val Gln Asn Val Thr Thr Glu Asp Val Glu Lys Ala Thr Val Asp Asn 

545                 550                 555                 560 





Lys Asp Lys Leu Glu Glu Thr Ser Gly Leu Lys Ile Leu Gln Thr Gly 

                565                 570                 575     





Val Gly Ser Lys Ser Lys Leu Lys Phe Leu Pro Pro Gln Ala Glu Gln 

            580                 585                 590         





Glu Asp Ser Thr Lys Phe Ile Ala Leu Thr Leu Val Ser Leu Ala Cys 

        595                 600                 605             





Ile Leu Gly Val Leu Leu Ala Ser Gly Leu Ile Tyr Cys Leu Arg His 

    610                 615                 620                 





Ser Ser Gln His Arg Leu Lys Glu Lys Leu Ser Gly Leu Gly Gly Asp 

625                 630                 635                 640 





Pro Gly Ala Asp Ala Thr Ala Ala Tyr Gln Glu Leu Cys Arg Gln Arg 

                645                 650                 655     





Met Ala Thr Arg Pro Pro Asp Arg Pro Glu Gly Pro His Thr Ser Arg 

            660                 665                 670         





Ile Ser Ser Val Ser Ser Gln Phe Ser Asp Gly Pro Ile Pro Ser Pro 

        675                 680                 685             





Ser Ala Arg Ser Ser Ala Ser Ser Trp Ser Glu Glu Pro Val Gln Ser 

    690                 695                 700                 





Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ser Tyr Met Glu Asp 

705                 710                 715                 720 





His Leu Lys Asn Lys Asn Arg Leu Glu Lys Glu Trp Glu Ala Leu Cys 

                725                 730                 735     





Ala Tyr Gln Ala Glu Pro Asn Ser Ser Phe Val Ala Gln Arg Glu Glu 

            740                 745                 750         





Asn Val Pro Lys Asn Arg Ser Leu Ala Val Leu Thr Tyr Asp His Ser 

        755                 760                 765             





Arg Val Leu Leu Lys Ala Glu Asn Ser His Ser His Ser Asp Tyr Ile 

    770                 775                 780                 





Asn Ala Ser Pro Ile Met Asp His Asp Pro Arg Asn Pro Ala Tyr Ile 

785                 790                 795                 800 





Ala Thr Gln Gly Pro Leu Pro Ala Thr Val Ala Asp Phe Trp Gln Met 

                805                 810                 815     





Val Trp Glu Ser Gly Cys Val Val Ile Val Met Leu Thr Pro Leu Ala 

            820                 825                 830         





Glu Asn Gly Val Arg Gln Cys Tyr His Tyr Trp Pro Asp Glu Gly Ser 

        835                 840                 845             





Asn Leu Tyr His Ile Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp 

    850                 855                 860                 





Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Leu Gln Thr 

865                 870                 875                 880 





Asn Glu Thr Arg Thr Val Thr Gln Phe His Phe Leu Ser Trp Tyr Asp 

                885                 890                 895     





Arg Gly Val Pro Ser Ser Ser Arg Ser Leu Leu Asp Phe Arg Arg Lys 

            900                 905                 910         





Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys 

        915                 920                 925             





Ser Asp Gly Ala Gly Arg Ser Gly Thr Tyr Val Leu Ile Asp Met Val 

    930                 935                 940                 





Leu Asn Lys Met Ala Lys Gly Ala Lys Glu Ile Asp Ile Ala Ala Thr 

945                 950                 955                 960 





Leu Glu His Leu Arg Asp Gln Arg Pro Gly Met Val Gln Thr Lys Glu 

                965                 970                 975     





Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile 

            980                 985                 990         





Leu Lys Ala Leu Pro Gln 

        995             





<210>  134

<211>  1015

<212>  PRT

<213>  Homo sapiens



<400>  134



Met Gly Pro Pro Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro 

1               5                   10                  15      





Pro Arg Val Leu Pro Ala Ala Pro Ser Ser Val Pro Arg Gly Arg Gln 

            20                  25                  30          





Leu Pro Gly Arg Leu Gly Cys Leu Leu Glu Glu Gly Leu Cys Gly Ala 

        35                  40                  45              





Ser Glu Ala Cys Val Asn Asp Gly Val Phe Gly Arg Cys Gln Lys Val 

    50                  55                  60                  





Pro Ala Met Asp Phe Tyr Arg Tyr Glu Val Ser Pro Val Ala Leu Gln 

65                  70                  75                  80  





Arg Leu Arg Val Ala Leu Gln Lys Leu Ser Gly Thr Gly Phe Thr Trp 

                85                  90                  95      





Gln Asp Asp Tyr Thr Gln Tyr Val Met Asp Gln Glu Leu Ala Asp Leu 

            100                 105                 110         





Pro Lys Thr Tyr Leu Arg Arg Pro Glu Ala Ser Ser Pro Ala Arg Pro 

        115                 120                 125             





Ser Lys His Ser Val Gly Ser Glu Arg Arg Tyr Ser Arg Glu Gly Gly 

    130                 135                 140                 





Ala Ala Leu Ala Asn Ala Leu Arg Arg His Leu Pro Phe Leu Glu Ala 

145                 150                 155                 160 





Leu Ser Gln Ala Pro Ala Ser Asp Val Leu Ala Arg Thr His Thr Ala 

                165                 170                 175     





Gln Asp Arg Pro Pro Ala Glu Gly Asp Asp Arg Phe Ser Glu Ser Ile 

            180                 185                 190         





Leu Thr Tyr Val Ala His Thr Ser Ala Leu Thr Tyr Pro Pro Gly Ser 

        195                 200                 205             





Arg Thr Gln Leu Arg Glu Asp Leu Leu Pro Arg Thr Leu Gly Gln Leu 

    210                 215                 220                 





Gln Pro Asp Glu Leu Ser Pro Lys Val Asp Ser Gly Val Asp Arg His 

225                 230                 235                 240 





His Leu Met Ala Ala Leu Ser Ala Tyr Ala Ala Gln Arg Pro Pro Ala 

                245                 250                 255     





Pro Pro Gly Glu Gly Ser Leu Glu Pro Gln Tyr Leu Leu Arg Ala Pro 

            260                 265                 270         





Ser Arg Met Pro Arg Pro Leu Leu Ala Pro Ala Ala Pro Gln Lys Trp 

        275                 280                 285             





Pro Ser Pro Leu Gly Asp Ser Glu Asp Pro Ser Ser Thr Gly Asp Gly 

    290                 295                 300                 





Ala Arg Ile His Thr Leu Leu Lys Asp Leu Gln Arg Gln Pro Ala Glu 

305                 310                 315                 320 





Val Arg Gly Leu Ser Gly Leu Glu Leu Asp Gly Met Ala Glu Leu Met 

                325                 330                 335     





Ala Gly Leu Met Gln Gly Val Asp His Gly Val Ala Arg Gly Ser Pro 

            340                 345                 350         





Gly Arg Ala Ala Leu Gly Glu Ser Gly Glu Gln Ala Asp Gly Pro Lys 

        355                 360                 365             





Ala Thr Leu Arg Gly Asp Ser Phe Pro Asp Asp Gly Val Gln Asp Asp 

    370                 375                 380                 





Asp Asp Arg Leu Tyr Gln Glu Val His Arg Leu Ser Ala Thr Leu Gly 

385                 390                 395                 400 





Gly Leu Leu Gln Asp His Gly Ser Arg Leu Leu Pro Gly Ala Leu Pro 

                405                 410                 415     





Phe Ala Arg Pro Leu Asp Met Glu Arg Lys Lys Ser Glu His Pro Glu 

            420                 425                 430         





Ser Ser Leu Ser Ser Glu Glu Glu Thr Ala Gly Val Glu Asn Val Lys 

        435                 440                 445             





Ser Gln Thr Tyr Ser Lys Asp Leu Leu Gly Gln Gln Pro His Ser Glu 

    450                 455                 460                 





Pro Gly Ala Ala Ala Phe Gly Glu Leu Gln Asn Gln Met Pro Gly Pro 

465                 470                 475                 480 





Ser Lys Glu Glu Gln Ser Leu Pro Ala Gly Ala Gln Glu Ala Leu Ser 

                485                 490                 495     





Asp Gly Leu Gln Leu Glu Val Gln Pro Ser Glu Glu Glu Ala Arg Gly 

            500                 505                 510         





Tyr Ile Val Thr Asp Arg Asp Pro Leu Arg Pro Glu Glu Gly Arg Arg 

        515                 520                 525             





Leu Val Glu Asp Val Ala Arg Leu Leu Gln Val Pro Ser Ser Ala Phe 

    530                 535                 540                 





Ala Asp Val Glu Val Leu Gly Pro Ala Val Thr Phe Lys Val Ser Ala 

545                 550                 555                 560 





Asn Val Gln Asn Val Thr Thr Glu Asp Val Glu Lys Ala Thr Val Asp 

                565                 570                 575     





Asn Lys Asp Lys Leu Glu Glu Thr Ser Gly Leu Lys Ile Leu Gln Thr 

            580                 585                 590         





Gly Val Gly Ser Lys Ser Lys Leu Lys Phe Leu Pro Pro Gln Ala Glu 

        595                 600                 605             





Gln Glu Asp Ser Thr Lys Phe Ile Ala Leu Thr Leu Val Ser Leu Ala 

    610                 615                 620                 





Cys Ile Leu Gly Val Leu Leu Ala Ser Gly Leu Ile Tyr Cys Leu Arg 

625                 630                 635                 640 





His Ser Ser Gln His Arg Leu Lys Glu Lys Leu Ser Gly Leu Gly Gly 

                645                 650                 655     





Asp Pro Gly Ala Asp Ala Thr Ala Ala Tyr Gln Glu Leu Cys Arg Gln 

            660                 665                 670         





Arg Met Ala Thr Arg Pro Pro Asp Arg Pro Glu Gly Pro His Thr Ser 

        675                 680                 685             





Arg Ile Ser Ser Val Ser Ser Gln Phe Ser Asp Gly Pro Ile Pro Ser 

    690                 695                 700                 





Pro Ser Ala Arg Ser Ser Ala Ser Ser Trp Ser Glu Glu Pro Val Gln 

705                 710                 715                 720 





Ser Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ser Tyr Met Glu 

                725                 730                 735     





Asp His Leu Lys Asn Lys Asn Arg Leu Glu Lys Glu Trp Glu Ala Leu 

            740                 745                 750         





Cys Ala Tyr Gln Ala Glu Pro Asn Ser Ser Phe Val Ala Gln Arg Glu 

        755                 760                 765             





Glu Asn Val Pro Lys Asn Arg Ser Leu Ala Val Leu Thr Tyr Asp His 

    770                 775                 780                 





Ser Arg Val Leu Leu Lys Ala Glu Asn Ser His Ser His Ser Asp Tyr 

785                 790                 795                 800 





Ile Asn Ala Ser Pro Ile Met Asp His Asp Pro Arg Asn Pro Ala Tyr 

                805                 810                 815     





Ile Ala Thr Gln Gly Pro Leu Pro Ala Thr Val Ala Asp Phe Trp Gln 

            820                 825                 830         





Met Val Trp Glu Ser Gly Cys Val Val Ile Val Met Leu Thr Pro Leu 

        835                 840                 845             





Ala Glu Asn Gly Val Arg Gln Cys Tyr His Tyr Trp Pro Asp Glu Gly 

    850                 855                 860                 





Ser Asn Leu Tyr His Ile Tyr Glu Val Asn Leu Val Ser Glu His Ile 

865                 870                 875                 880 





Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Leu Gln 

                885                 890                 895     





Thr Asn Glu Thr Arg Thr Val Thr Gln Phe His Phe Leu Ser Trp Tyr 

            900                 905                 910         





Asp Arg Gly Val Pro Ser Ser Ser Arg Ser Leu Leu Asp Phe Arg Arg 

        915                 920                 925             





Lys Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His 

    930                 935                 940                 





Cys Ser Asp Gly Ala Gly Arg Ser Gly Thr Tyr Val Leu Ile Asp Met 

945                 950                 955                 960 





Val Leu Asn Lys Met Ala Lys Gly Ala Lys Glu Ile Asp Ile Ala Ala 

                965                 970                 975     





Thr Leu Glu His Leu Arg Asp Gln Arg Pro Gly Met Val Gln Thr Lys 

            980                 985                 990         





Glu Gln Phe Glu Phe Ala Leu Thr  Ala Val Ala Glu Glu  Val Asn Ala 

        995                 1000                 1005             





Ile Leu  Lys Ala Leu Pro Gln  

    1010                 1015 





<210>  135

<211>  224

<212>  PRT

<213>  Homo sapiens



<400>  135



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 

        195                 200                 205             





Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 

    210                 215                 220                 





<210>  136

<211>  206

<212>  PRT

<213>  Homo sapiens



<400>  136



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Val Phe His Leu Glu Ala Leu Ser Gly 

        195                 200                 205     





<210>  137

<211>  108

<212>  PRT

<213>  Homo sapiens



<400>  137



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Asp Pro Phe 

            20                  25                  30          





Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val 

        35                  40                  45              





Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu Cys Leu Gln Tyr 

    50                  55                  60                  





Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr 

65                  70                  75                  80  





Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys Glu Pro Lys Lys 

                85                  90                  95      





Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 

            100                 105             





<210>  138

<211>  252

<212>  PRT

<213>  Homo sapiens



<400>  138



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 

        195                 200                 205             





Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 

    210                 215                 220                 





Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 

225                 230                 235                 240 





Glu Glu Leu Leu Phe His Leu Glu Ala Leu Ser Gly 

                245                 250         





<210>  139

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  139



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 

        195                 200                 205             





Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 

    210                 215                 220                 





Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 

225                 230                 235                 240 





Glu Glu Leu Arg Asn Pro Phe 

                245         





<210>  140

<211>  213

<212>  PRT

<213>  Homo sapiens



<400>  140



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 

        195                 200                 205             





Glu Ala Leu Ser Gly 

    210             





<210>  141

<211>  229

<212>  PRT

<213>  Homo sapiens



<400>  141



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 

        195                 200                 205             





Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 

    210                 215                 220                 





Glu Ala Leu Ser Gly 

225                 





<210>  142

<211>  208

<212>  PRT

<213>  Homo sapiens



<400>  142



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 

            20                  25                  30          





Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 

        35                  40                  45              





Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 

    50                  55                  60                  





Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 

65                  70                  75                  80  





Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 

                85                  90                  95      





Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 

            100                 105                 110         





Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 

        115                 120                 125             





Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 

    130                 135                 140                 





Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 

145                 150                 155                 160 





Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 

                165                 170                 175     





Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 

            180                 185                 190         





Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 

        195                 200                 205             





<210>  143

<211>  131

<212>  PRT

<213>  Homo sapiens



<400>  143



Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 

1               5                   10                  15      





Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Asp Pro Phe 

            20                  25                  30          





Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val 

        35                  40                  45              





Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu Cys Leu Gln Tyr 

    50                  55                  60                  





Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr 

65                  70                  75                  80  





Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile Thr Leu Phe 

                85                  90                  95      





Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu Ile Ile Cys Tyr 

            100                 105                 110         





Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu Glu Glu Leu Arg 

        115                 120                 125             





Asn Pro Phe 

    130     





<210>  144

<211>  171

<212>  PRT

<213>  Homo sapiens



<400>  144



Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 

1               5                   10                  15      





Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 

            20                  25                  30          





His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 

        35                  40                  45              





Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 

    50                  55                  60                  





Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 

65                  70                  75                  80  





Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 

                85                  90                  95      





Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu 

            100                 105                 110         





Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr 

        115                 120                 125             





Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly 

    130                 135                 140                 





Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg 

145                 150                 155                 160 





Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 

                165                 170     





<210>  145

<211>  160

<212>  PRT

<213>  Homo sapiens



<400>  145



Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 

1               5                   10                  15      





Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 

            20                  25                  30          





His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 

        35                  40                  45              





Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 

    50                  55                  60                  





Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 

65                  70                  75                  80  





Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 

                85                  90                  95      





Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg 

            100                 105                 110         





Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 

        115                 120                 125             





Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 

    130                 135                 140                 





Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 

145                 150                 155                 160 





<210>  146

<211>  197

<212>  PRT

<213>  Homo sapiens



<400>  146



Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 

1               5                   10                  15      





Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 

            20                  25                  30          





Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 

        35                  40                  45              





Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 

    50                  55                  60                  





Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 

65                  70                  75                  80  





His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 

                85                  90                  95      





Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 

            100                 105                 110         





Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 

        115                 120                 125             





Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 

    130                 135                 140                 





Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 

145                 150                 155                 160 





Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 

                165                 170                 175     





Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 

            180                 185                 190         





Val Ser Ser Glu Glu 

        195         





<210>  147

<211>  304

<212>  PRT

<213>  Homo sapiens



<400>  147



Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 

1               5                   10                  15      





Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 

            20                  25                  30          





Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 

        35                  40                  45              





Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 

    50                  55                  60                  





Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 

65                  70                  75                  80  





His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 

                85                  90                  95      





Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 

            100                 105                 110         





Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 

        115                 120                 125             





Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 

    130                 135                 140                 





Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 

145                 150                 155                 160 





Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 

                165                 170                 175     





Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 

            180                 185                 190         





Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 

        195                 200                 205             





Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 

    210                 215                 220                 





Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 

225                 230                 235                 240 





Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg 

                245                 250                 255     





Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 

            260                 265                 270         





Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 

        275                 280                 285             





Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 

    290                 295                 300                 





<210>  148

<211>  186

<212>  PRT

<213>  Homo sapiens



<400>  148



Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 

1               5                   10                  15      





Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 

            20                  25                  30          





His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 

        35                  40                  45              





Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 

    50                  55                  60                  





Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 

65                  70                  75                  80  





Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 

                85                  90                  95      





Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 

            100                 105                 110         





Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 

        115                 120                 125             





Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly 

    130                 135                 140                 





Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val 

145                 150                 155                 160 





Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp 

                165                 170                 175     





Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 

            180                 185     





<210>  149

<211>  277

<212>  PRT

<213>  Homo sapiens



<400>  149



Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 

1               5                   10                  15      





Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 

            20                  25                  30          





Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 

        35                  40                  45              





Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 

    50                  55                  60                  





Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 

65                  70                  75                  80  





Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 

                85                  90                  95      





Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 

            100                 105                 110         





Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 

        115                 120                 125             





Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 

    130                 135                 140                 





Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 

145                 150                 155                 160 





Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 

                165                 170                 175     





Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 

            180                 185                 190         





Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 

        195                 200                 205             





Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 

    210                 215                 220                 





Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 

225                 230                 235                 240 





Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 

                245                 250                 255     





Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 

            260                 265                 270         





Arg Gly Thr Lys Phe 

        275         





<210>  150

<211>  242

<212>  PRT

<213>  Homo sapiens



<400>  150



Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 

1               5                   10                  15      





Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 

            20                  25                  30          





Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 

        35                  40                  45              





Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 

    50                  55                  60                  





Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 

65                  70                  75                  80  





Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 

                85                  90                  95      





Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 

            100                 105                 110         





Leu Ser Ala Thr Phe Val Gly Ile Thr Tyr Ala Leu Thr Val Val Trp 

        115                 120                 125             





Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn 

    130                 135                 140                 





Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala 

145                 150                 155                 160 





Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro 

                165                 170                 175     





Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser Ile 

            180                 185                 190         





Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe Ile Ala Ala 

        195                 200                 205             





Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr Phe Met Ile 

    210                 215                 220                 





Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg Gly Thr 

225                 230                 235                 240 





Lys Phe 

        





<210>  151

<211>  246

<212>  PRT

<213>  Artificial sequence



<220>

<223>  RTL1000-BirA



<400>  151



Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu 

1               5                   10                  15      





Tyr Arg Asn Gly Lys Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser 

            20                  25                  30          





Gly Gly Gly Gly Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His 

        35                  40                  45              





Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr 

    50                  55                  60                  





Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 

65                  70                  75                  80  





Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 

                85                  90                  95      





Lys Asp Ile Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg 

            100                 105                 110         





His Asn Tyr Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Ile 

        115                 120                 125             





Lys Glu Glu His Asp Ile Asp Gln Asp Glu Asp Tyr Asp Asn Pro Asp 

    130                 135                 140                 





Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe His 

145                 150                 155                 160 





Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe Gly 

                165                 170                 175     





Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val 

            180                 185                 190         





Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro 

        195                 200                 205             





Ile Thr Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 

    210                 215                 220                 





Gly Ser Gly Gly Gly Gly Ser Leu His His Ile Leu Asp Ala Gln Lys 

225                 230                 235                 240 





Met Val Trp Asn His Arg 

                245     





<210>  152

<211>  209

<212>  PRT

<213>  Artificial sequence



<220>

<223>  RTL340-BirA



<400>  152



Met Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 

1               5                   10                  15      





Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Pro 

            20                  25                  30          





Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn Gly Thr 

        35                  40                  45              





Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu Glu Ser 

    50                  55                  60                  





Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 

65                  70                  75                  80  





Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 

                85                  90                  95      





Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val 

            100                 105                 110         





Val Glu Ser Phe Thr Val Gln Arg Arg Val Ile Lys Glu Glu His Asp 

        115                 120                 125             





Ile Asp Gln Asp Glu Asp Tyr Asp Asn Pro Asp Gln Ser Gly Glu Phe 

    130                 135                 140                 





Met Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys 

145                 150                 155                 160 





Lys Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe 

                165                 170                 175     





Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu 

            180                 185                 190         





Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Gly Gly 

        195                 200                 205             





Gly 

    





<210>  153

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  A linker between antigenic peptide and  Beta-1 domain



<400>  153



Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly 

1               5                   10                  15  





<210>  154

<211>  91

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Beta-1 domain of DR2



<400>  154



Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn Gly 

1               5                   10                  15      





Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu Glu 

            20                  25                  30          





Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu 

        35                  40                  45              





Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu 

    50                  55                  60                  





Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly 

65                  70                  75                  80  





Val Val Glu Ser Phe Thr Val Gln Arg Arg Val 

                85                  90      





<210>  155

<211>  84

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Alpha-1 domain of DR2



<400>  155



Ile Lys Glu Glu His Asp Ile Asp Gln Asp Glu Asp Tyr Asp Asn Pro 

1               5                   10                  15      





Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 

            20                  25                  30          





His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 

        35                  40                  45              





Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 

    50                  55                  60                  





Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 

65                  70                  75                  80  





Pro Ile Thr Asn 

                





<210>  156

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  A linker peptide connecting the Alpha-1 domain with the BirA tag



<400>  156



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 

1               5                   10                  15      





Gly Gly Gly Ser 

            20  





<210>  157

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  BirA tag



<400>  157



Leu His His Ile Leu Asp Ala Gln Lys Met Val Trp Asn His Arg 

1               5                   10                  15  





<210>  158

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  MHC class II insulin A1 antigenic peptide



<400>  158



Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 

1               5                   10                  15  





<210>  159

<211>  180

<212>  PRT

<213>  Artificial sequence



<220>

<223>  RTL800 (HLA-DQ2)



<400>  159



Met Gly Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys 

1               5                   10                  15      





His Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe 

            20                  25                  30          





Tyr His Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Phe 

        35                  40                  45              





Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser 

    50                  55                  60                  





Gln Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys 

65                  70                  75                  80  





Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 

                85                  90                  95      





Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 

            100                 105                 110         





Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 

        115                 120                 125             





His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 

    130                 135                 140                 





Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 

145                 150                 155                 160 





Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 

                165                 170                 175     





Pro Ile Thr Asn 

            180 





<210>  160

<211>  549

<212>  DNA

<213>  Artificial sequence



<220>

<223>  RTL800 (HLA-DQ2)



<400>  160

atgggggaca cccgaccacg cttcctggag caggttaaac atgagtgtca tttcttcaat       60



gggacggagc gggtgcggtt cctggacaga tacttctatc accaagagga gtacgtgcgc      120



ttcgacagcg acgtggggga gttccgggcg gtgacggagc tggggcggcc tgacgctgag      180



tactggaaca gccagaagga cctcctggag cagaagcggg ccgcggtgga cacctactgc      240



agacacaact acggggttgg tgagagcttc acagtgcagc ggcgagtcat caaagaagaa      300



catgtgatca tccaggccga gttctatctg aatcctgacc aatcaggcga gtttatgttt      360



gactttgatg gtgatgagat tttccatgtg gatatggcaa agaaggagac ggtctggcgg      420



cttgaagaat ttggacgatt tgccagcttt gaggctcaag gtgcattggc caacatagct      480



gtggacaaag ccaacctgga aatcatgaca aagcgctcca actatactcc gatcaccaat      540



taactcgag                                                              549





<210>  161

<211>  178

<212>  PRT

<213>  Artificial sequence



<220>

<223>  RTL600 (HLA-DP2)



<400>  161



Met Gly Asp Thr Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys 

1               5                   10                  15      





Tyr Ala Phe Asn Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn 

            20                  25                  30          





Arg Glu Glu Phe Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala 

        35                  40                  45              





Val Thr Glu Leu Gly Arg Pro Asp Glu Glu Tyr Trp Asn Ser Gln Lys 

    50                  55                  60                  





Asp Ile Leu Glu Glu Glu Arg Ala Val Pro Asp Arg Met Cys Arg His 

65                  70                  75                  80  





Asn Tyr Glu Leu Gly Gly Pro Met Thr Leu Gln Arg Arg Val Ile Lys 

                85                  90                  95      





Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg Pro 

            100                 105                 110         





Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr Val 

        115                 120                 125             





Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly Gln 

    130                 135                 140                 





Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile Leu 

145                 150                 155                 160 





Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln Ala 

                165                 170                 175     





Thr Asn 

        





<210>  162

<211>  543

<212>  DNA

<213>  Artificial sequence



<220>

<223>  RTL600 (HLA-DP2)



<400>  162

atgggggaca ctccggagaa ttaccttttc cagggacggc aggaatgcta cgcgtttaat       60



gggacacagc gcttcctgga gagatacatc tacaaccggg aggagttcgt gcgcttcgac      120



agcgacgtgg gggagttccg ggcggtgacg gagctggggc ggcctgatga ggagtactgg      180



aacagccaga aggacatcct ggaggaggag cgggcagtgc cggacaggat gtgcagacac      240



aactacgagc tgggcgggcc catgaccctg cagcgccgag tcatcaaagc ggaccatgtg      300



tcaacttatg ccgcgtttgt acagacgcat agaccaacag gggagtttat gtttgaattt      360



gatgaagatg agatgttcta tgtggatctg gacaagaagg agaccgtctg gcatctggag      420



gagtttggcc aagccttttc ctttgaggct cagggcgggc tggctaacat tgctatattg      480



aacaacaact tgaatacctt gatccagcgt tccaaccaca ctcaggccac caactaactc      540



gag                                                                    543





<210>  163

<211>  211

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Empty RTL 302 (empty DR2)



<400>  163



Met Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 

1               5                   10                  15      





Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 

            20                  25                  30          





Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 

        35                  40                  45              





Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 

    50                  55                  60                  





Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 

65                  70                  75                  80  





Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Ile Lys Glu Glu 

                85                  90                  95      





His Asp Ile Asp Gln Asp Glu Asp Tyr Asp Asn Pro Asp Gln Ser Gly 

            100                 105                 110         





Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met 

        115                 120                 125             





Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala 

    130                 135                 140                 





Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala 

145                 150                 155                 160 





Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn 

                165                 170                 175     





Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 

            180                 185                 190         





Gly Gly Gly Ser Leu His His Ile Leu Asp Ala Gln Lys Met Val Trp 

        195                 200                 205             





Asn His Arg 

    210     





<210>  164

<211>  633

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Empty RTL 302 (empty DR2)



<400>  164

atgccacgtt tcctgtggca gcctaagagg gagtgtcatt tcttcaatgg gacggagcgg       60



gtgcggttcc tggacagata cttctataac caggaggagt ccgtgcgctt cgacagcgac      120



gtgggggagt tccgggcggt gacggagctg gggcggcctg acgctgagta ctggaacagc      180



cagaaggaca tcctggagca ggcgcgggcc gcggtggaca cctactgcag acacaactac      240



ggggttgtgg agagcttcac agtgcagcgg cgagtcatca aagaagaaca tgacatcgac      300



caggacgagg actatgacaa tcctgaccaa tcaggcgagt ttatgtttga ctttgatggt      360



gatgagattt tccatgtgga tatggcaaag aaggagacgg tctggcggct tgaagaattt      420



ggacgatttg ccagctttga ggctcaaggt gcattggcca acatagctgt ggacaaagcc      480



aacttggaaa tcatgacaaa gcgctccaac tatactccga tcaccaatgg tggcggtgga      540



agcggtggcg gtggaagcgg tggcggtgga agcggtggcg gtggaagcct gcaccatatc      600



ctggacgccc agaagatggt gtggaatcac cgc                                   633





<210>  165

<211>  8

<212>  PRT

<213>  Artificial sequence



<220>

<223>  A linker between antigenic peptide and the Beta-1 domain of DR4



<400>  165



Gly Ser Gly Ser Gly Ser Gly Ser 

1               5               





<210>  166

<211>  95

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Beta-1 domain DR4



<400>  166



Gly Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His 

1               5                   10                  15      





Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr 

            20                  25                  30          





His Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg 

        35                  40                  45              





Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 

    50                  55                  60                  





Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg 

65                  70                  75                  80  





His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 

                85                  90                  95  





<210>  167

<211>  84

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Alpha-1 domain DR4



<400>  167



Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 

1               5                   10                  15      





Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 

            20                  25                  30          





His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 

        35                  40                  45              





Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 

    50                  55                  60                  





Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 

65                  70                  75                  80  





Pro Ile Thr Asn 

                





<210>  168

<211>  238

<212>  PRT

<213>  Artificial sequence



<220>

<223>  RTL2011



<400>  168



Met Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 

1               5                   10                  15      





Gly Ser Gly Ser Gly Ser Gly Ser Gly Asp Thr Arg Pro Arg Phe Leu 

            20                  25                  30          





Glu Gln Val Lys His Glu Cys His Phe Phe Asn Gly Thr Glu Arg Val 

        35                  40                  45              





Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu Glu Tyr Val Arg Phe 

    50                  55                  60                  





Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro 

65                  70                  75                  80  





Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu Gln Lys Arg 

                85                  90                  95      





Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val Gly Glu Ser 

            100                 105                 110         





Phe Thr Val Gln Arg Arg Val Ile Lys Glu Glu His Val Ile Ile Gln 

        115                 120                 125             





Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp 

    130                 135                 140                 





Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr 

145                 150                 155                 160 





Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln 

                165                 170                 175     





Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met 

            180                 185                 190         





Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Gly Gly Gly Gly Ser 

        195                 200                 205             





Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 

    210                 215                 220                 





His His Ile Leu Asp Ala Gln Lys Met Val Trp Asn His Arg 

225                 230                 235             





<210>  169

<211>  236

<212>  PRT

<213>  Artificial sequence



<220>

<223>  RTL2010



<400>  169



Met Met Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr Gly Ser 

1               5                   10                  15      





Gly Ser Gly Ser Gly Ser Gly Asp Thr Arg Pro Arg Phe Leu Glu Gln 

            20                  25                  30          





Val Lys His Glu Cys His Phe Phe Asn Gly Thr Glu Arg Val Arg Phe 

        35                  40                  45              





Leu Asp Arg Tyr Phe Tyr His Gln Glu Glu Tyr Val Arg Phe Asp Ser 

    50                  55                  60                  





Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala 

65                  70                  75                  80  





Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala 

                85                  90                  95      





Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr 

            100                 105                 110         





Val Gln Arg Arg Val Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu 

        115                 120                 125             





Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp 

    130                 135                 140                 





Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp 

145                 150                 155                 160 





Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala 

                165                 170                 175     





Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys 

            180                 185                 190         





Arg Ser Asn Tyr Thr Pro Ile Thr Asn Gly Gly Gly Gly Ser Gly Gly 

        195                 200                 205             





Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu His His 

    210                 215                 220                 





Ile Leu Asp Ala Gln Lys Met Val Trp Asn His Arg 

225                 230                 235     





<210>  170

<211>  738

<212>  DNA

<213>  Artificial sequence



<220>

<223>  RTL1000-BirA



<400>  170

atggaagttg gttggtaccg tccgccgttc tcccgtgttg ttcacctgta ccgtaacggt       60



aaaggaggtg gaggctcact agtgccccga ggctctggag gtggaggccc acgtttcctg      120



tggcagccta agagggagtg tcatttcttc aatgggacgg agcgggtgcg gttcctggac      180



agatacttct ataaccagga ggagtccgtg cgcttcgaca gcgacgtggg ggagttccgg      240



gcggtgacgg agctggggcg gcctgacgct gagtactgga acagccagaa ggacatcctg      300



gagcaggcgc gggccgcggt ggacacctac tgcagacaca actacggggt tgtggagagc      360



ttcacagtgc agcggcgagt catcaaagaa gaacatgaca tcgaccagga cgaggactat      420



gacaatcctg accaatcagg cgagtttatg tttgactttg atggtgatga gattttccat      480



gtggatatgg caaagaagga gacggtctgg cggcttgaag aatttggacg atttgccagc      540



tttgaggctc aaggtgcatt ggccaacata gctgtggaca aagccaactt ggaaatcatg      600



acaaagcgct ccaactatac tccgatcacc aatggtggcg gtggaagcgg tggcggtgga      660



agcggtggcg gtggaagcgg tggcggtgga agcctgcacc atatcctgga cgcccagaag      720



atggtgtgga atcaccgc                                                    738





<210>  171

<211>  63

<212>  DNA

<213>  Artificial sequence



<220>

<223>  sequence encoding peptide MOG-35-55



<400>  171

atggaagttg gttggtaccg tccgccgttc tcccgtgttg ttcacctgta ccgtaacggt       60



aaa                                                                     63





<210>  172

<211>  45

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Sequence encoding a linker between antigenic peptide and the 

       Beta1 domain in RTL



<400>  172

ggaggtggag gctcactagt gccccgaggc tctggaggtg gaggc                       45





<210>  173

<211>  273

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Sequence encoding  Beta-1 domain of DR2



<400>  173

ccacgtttcc tgtggcagcc taagagggag tgtcatttct tcaatgggac ggagcgggtg       60



cggttcctgg acagatactt ctataaccag gaggagtccg tgcgcttcga cagcgacgtg      120



ggggagttcc gggcggtgac ggagctgggg cggcctgacg ctgagtactg gaacagccag      180



aaggacatcc tggagcaggc gcgggccgcg gtggacacct actgcagaca caactacggg      240



gttgtggaga gcttcacagt gcagcggcga gtc                                   273





<210>  174

<211>  252

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Sequence encoding  Alpha-1 domain of DR2



<400>  174

atcaaagaag aacatgacat cgaccaggac gaggactatg acaatcctga ccaatcaggc       60



gagtttatgt ttgactttga tggtgatgag attttccatg tggatatggc aaagaaggag      120



acggtctggc ggcttgaaga atttggacga tttgccagct ttgaggctca aggtgcattg      180



gccaacatag ctgtggacaa agccaacttg gaaatcatga caaagcgctc caactatact      240



ccgatcacca at                                                          252





<210>  175

<211>  60

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Sequence encoding a linker between  Alpha-1 domain and the BirA 

       tag in RTL



<400>  175

ggtggcggtg gaagcggtgg cggtggaagc ggtggcggtg gaagcggtgg cggtggaagc       60





<210>  176

<211>  45

<212>  DNA

<213>  Artificial sequence



<220>

<223>  A sequence encoding for the BirA tag



<400>  176

ctgcaccata tcctggacgc ccagaagatg gtgtggaatc accgc                       45





<210>  177

<211>  46

<212>  DNA

<213>  Artificial sequence



<220>

<223>  A sequence encoding insulin A-1-15 antigenic peptide



<400>  177

ggtatcgttg aacagtgttg taccagcatc tgcagcctgt atcagg                      46





<210>  178

<211>  23

<212>  DNA

<213>  Artificial sequence



<220>

<223>  sequence encoding a linker between an antigenic peptide and the 

       Beta-1 domain in RTL



<400>  178

gttctggttc tggttctggt tct                                               23





<210>  179

<211>  285

<212>  DNA

<213>  Artificial sequence



<220>

<223>  A sequence encoding  the  Beta-1 domain DR4



<400>  179

ggggacaccc gaccacgctt cctggagcag gttaaacatg agtgtcattt cttcaatggg       60



acggagcggg tgcggttcct ggacagatac ttctatcacc aagaggagta cgtgcgcttc      120



gacagcgacg tgggggagtt ccgggcggtg acggagctgg ggcggcctga cgctgagtac      180



tggaacagcc agaaggacct cctggagcag aagcgggccg cggtggacac ctactgcaga      240



cacaactacg gggttggtga gagcttcaca gtgcagcggc gagtc                      285





<210>  180

<211>  252

<212>  DNA

<213>  Artificial sequence



<220>

<223>  A sequence encoding  the  Alpha-1 domain DR4



<400>  180

atcaaagaag aacatgacat cgaccaggac gaggactatg acaatcctga ccaatcaggc       60



gagtttatgt ttgactttga tggtgatgag attttccatg tggatatggc aaagaaggag      120



acggtctggc ggcttgaaga atttggacga tttgccagct ttgaggctca aggtgcattg      180



gccaacatag ctgtggacaa agccaacttg gaaatcatga caaagcgctc caactatact      240



ccgatcacca at                                                          252





<210>  181

<211>  714

<212>  DNA

<213>  Artificial sequence



<220>

<223>  RTL2011



<400>  181

atgggtatcg ttgaacagtg ttgtaccagc atctgcagcc tgtatcaggg ttctggttct       60



ggttctggtt ctggggacac ccgaccacgc ttcctggagc aggttaaaca tgagtgtcat      120



ttcttcaatg ggacggagcg ggtgcggttc ctggacagat acttctatca ccaagaggag      180



tacgtgcgct tcgacagcga cgtgggggag ttccgggcgg tgacggagct ggggcggcct      240



gacgctgagt actggaacag ccagaaggac ctcctggagc agaagcgggc cgcggtggac      300



acctactgca gacacaacta cggggttggt gagagcttca cagtgcagcg gcgagtcatc      360



aaagaagaac atgacatcga ccaggacgag gactatgaca atcctgacca atcaggcgag      420



tttatgtttg actttgatgg tgatgagatt ttccatgtgg atatggcaaa gaaggagacg      480



gtctggcggc ttgaagaatt tggacgattt gccagctttg aggctcaagg tgcattggcc      540



aacatagctg tggacaaagc caacttggaa atcatgacaa agcgctccaa ctatactccg      600



atcaccaatg gtggcggtgg aagcggtggc ggtggaagcg gtggcggtgg aagcggtggc      660



ggtggaagcc tgcaccatat cctggacgcc cagaagatgg tgtggaatca ccgc            714





<210>  182

<211>  708

<212>  DNA

<213>  Artificial sequence



<220>

<223>  RTL2010



<400>  182

atgaacttct ttcgtatggt tatcagcaat ccagctgcga ctggttctgg ttctggttct       60



ggttctgggg acacccgacc acgcttcctg gagcaggtta aacatgagtg tcatttcttc      120



aatgggacgg agcgggtgcg gttcctggac agatacttct atcaccaaga ggagtacgtg      180



cgcttcgaca gcgacgtggg ggagttccgg gcggtgacgg agctggggcg gcctgacgct      240



gagtactgga acagccagaa ggacctcctg gagcagaagc gggccgcggt ggacacctac      300



tgcagacaca actacggggt tggtgagagc ttcacagtgc agcggcgagt catcaaagaa      360



gaacatgaca tcgaccagga cgaggactat gacaatcctg accaatcagg cgagtttatg      420



tttgactttg atggtgatga gattttccat gtggatatgg caaagaagga gacggtctgg      480



cggcttgaag aatttggacg atttgccagc tttgaggctc aaggtgcatt ggccaacata      540



gctgtggaca aagccaactt ggaaatcatg acaaagcgct ccaactatac tccgatcacc      600



aatggtggcg gtggaagcgg tggcggtgga agcggtggcg gtggaagcgg tggcggtgga      660



agcctgcacc atatcctgga cgcccagaag atggtgtgga atcaccgc                   708





<210>  183

<211>  40

<212>  DNA

<213>  Artificial sequence



<220>

<223>  A sequence encoding GAD-555-567 antigenic peptide



<400>  183

aacttctttc gtatggttat cagcaatcca gctgcgactg                             40





<210>  184

<211>  96

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Beta-1 domain HLA-DQ2



<400>  184



Met Gly Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys 

1               5                   10                  15      





His Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe 

            20                  25                  30          





Tyr His Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Phe 

        35                  40                  45              





Arg Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser 

    50                  55                  60                  





Gln Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys 

65                  70                  75                  80  





Arg His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 

                85                  90                  95      





<210>  185

<211>  84

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Alpha-1 domain HLA-DQ2



<400>  185



Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 

1               5                   10                  15      





Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 

            20                  25                  30          





His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 

        35                  40                  45              





Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 

    50                  55                  60                  





Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 

65                  70                  75                  80  





Pro Ile Thr Asn 

                





<210>  186

<211>  288

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Beta-1 domain HLA-DQ2



<400>  186

atgggggaca cccgaccacg cttcctggag caggttaaac atgagtgtca tttcttcaat       60



gggacggagc gggtgcggtt cctggacaga tacttctatc accaagagga gtacgtgcgc      120



ttcgacagcg acgtggggga gttccgggcg gtgacggagc tggggcggcc tgacgctgag      180



tactggaaca gccagaagga cctcctggag cagaagcggg ccgcggtgga cacctactgc      240



agacacaact acggggttgg tgagagcttc acagtgcagc ggcgagtc                   288





<210>  187

<211>  261

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Alpha-1 domain HLA-DQ2



<400>  187

atcaaagaag aacatgtgat catccaggcc gagttctatc tgaatcctga ccaatcaggc       60



gagtttatgt ttgactttga tggtgatgag attttccatg tggatatggc aaagaaggag      120



acggtctggc ggcttgaaga atttggacga tttgccagct ttgaggctca aggtgcattg      180



gccaacatag ctgtggacaa agccaacctg gaaatcatga caaagcgctc caactatact      240



ccgatcacca attaactcga g                                                261





<210>  188

<211>  94

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Beta-1 domain of the empty RTL800



<400>  188



Met Gly Asp Thr Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys 

1               5                   10                  15      





Tyr Ala Phe Asn Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn 

            20                  25                  30          





Arg Glu Glu Phe Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala 

        35                  40                  45              





Val Thr Glu Leu Gly Arg Pro Asp Glu Glu Tyr Trp Asn Ser Gln Lys 

    50                  55                  60                  





Asp Ile Leu Glu Glu Glu Arg Ala Val Pro Asp Arg Met Cys Arg His 

65                  70                  75                  80  





Asn Tyr Glu Leu Gly Gly Pro Met Thr Leu Gln Arg Arg Val 

                85                  90                  





<210>  189

<211>  84

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Alpha-1 domain of the empty RTL800



<400>  189



Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His 

1               5                   10                  15      





Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe 

            20                  25                  30          





Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe 

        35                  40                  45              





Gly Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala 

    50                  55                  60                  





Ile Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr 

65                  70                  75                  80  





Gln Ala Thr Asn 

                





<210>  190

<211>  282

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Beta-1 domain of the empty RTL800



<400>  190

atgggggaca ctccggagaa ttaccttttc cagggacggc aggaatgcta cgcgtttaat       60



gggacacagc gcttcctgga gagatacatc tacaaccggg aggagttcgt gcgcttcgac      120



agcgacgtgg gggagttccg ggcggtgacg gagctggggc ggcctgatga ggagtactgg      180



aacagccaga aggacatcct ggaggaggag cgggcagtgc cggacaggat gtgcagacac      240



aactacgagc tgggcgggcc catgaccctg cagcgccgag tc                         282





<210>  191

<211>  261

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Alpha-1 domain of the empty RTL800



<400>  191

atcaaagcgg accatgtgtc aacttatgcc gcgtttgtac agacgcatag accaacaggg       60



gagtttatgt ttgaatttga tgaagatgag atgttctatg tggatctgga caagaaggag      120



accgtctggc atctggagga gtttggccaa gccttttcct ttgaggctca gggcgggctg      180



gctaacattg ctatattgaa caacaacttg aataccttga tccagcgttc caaccacact      240



caggccacca actaactcga g                                                261





<210>  192

<211>  45

<212>  DNA

<213>  Artificial sequence



<220>

<223>  DNA encoding the MBP-85-99 antigenic-peptide



<400>  192

gaaaacccgg ttgttcactt cttcaaaaac atcgttaccc cgcgt                       45





<210>  193

<211>  723

<212>  DNA

<213>  Artificial sequence



<220>

<223>  RTL340-BirA



<400>  193

atggaaaacc cggttgttca cttcttcaaa aacatcgtta ccccgcgtgg aggtggaggc       60



tcactagtgc cccgaggctc tggaggtgga ggcccacgtt tcctgtggca gcctaagagg      120



gagtgtcatt tcttcaatgg gacggagcgg gtgcggttcc tggacagata cttctataac      180



caggaggagt ccgtgcgctt cgacagcgac gtgggggagt tccgggcggt gacggagctg      240



gggcggcctg acgctgagta ctggaacagc cagaaggaca tcctggagca ggcgcgggcc      300



gcggtggaca cctactgcag acacaactac ggggttgtgg agagcttcac agtgcagcgg      360



cgagtcatca aagaagaaca tgacatcgac caggacgagg actatgacaa tcctgaccaa      420



tcaggcgagt ttatgtttga ctttgatggt gatgagattt tccatgtgga tatggcaaag      480



aaggagacgg tctggcggct tgaagaattt ggacgatttg ccagctttga ggctcaaggt      540



gcattggcca acatagctgt ggacaaagcc aacttggaaa tcatgacaaa gcgctccaac      600



tatactccga tcaccaatgg tggcggtgga agcggtggcg gtggaagcgg tggcggtgga      660



agcggtggcg gtggaagcct gcaccatatc ctggacgccc agaagatggt gtggaatcac      720



cgc                                                                    723





<210>  194

<211>  98

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  194

ttaagcgttg gcggaattct tatcagcggt gattccacac catcttctgg gcgtccagga       60



tatggtgcag agacccggga ttggtgatcg gagtatag                               98





<210>  195

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  CII-261-273 peptide



<400>  195



Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro 

1               5                   10              





<210>  196

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  HA-307-319 peptide



<400>  196



Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 

1               5                   10              





<210>  197

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  197



Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro 

1               5                   10      





<210>  198

<211>  22

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  198



Val Pro Val Pro Gln Leu Gln Pro Gln Asn Pro Ser Gln Gln Gln Pro 

1               5                   10                  15      





Gln Glu Gln Val Pro Leu 

            20          





<210>  199

<211>  279

<212>  PRT

<213>  Aegilops tauschii



<400>  199



Met Lys Thr Phe Leu Ile Leu Ala Leu Leu Ala Ile Val Ala Thr Thr 

1               5                   10                  15      





Ala Thr Thr Ala Val Arg Val Pro Val Pro Gln Leu Gln Pro Gln Asn 

            20                  25                  30          





Pro Ser Gln Gln Gln Pro Gln Glu Gln Val Pro Leu Val Gln Gln Gln 

        35                  40                  45              





Gln Phe Leu Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro 

    50                  55                  60                  





Gln Pro Gln Pro Phe Pro Ser Gln Gln Pro Tyr Leu Gln Leu Gln Pro 

65                  70                  75                  80  





Phe Pro Gln Pro Gln Leu Pro Tyr Ser Gln Pro Gln Pro Phe Arg Pro 

                85                  90                  95      





Gln Gln Pro Tyr Pro Gln Pro Gln Pro Gln Tyr Ser Gln Pro Gln Glu 

            100                 105                 110         





Pro Ile Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ile Leu 

        115                 120                 125             





Gln Gln Ile Leu Gln Gln Gln Leu Ile Pro Cys Met Asp Val Val Leu 

    130                 135                 140                 





Gln Gln His Asn Ile Ala His Gly Arg Ser Gln Val Leu Gln Gln Ser 

145                 150                 155                 160 





Thr Tyr Gln Leu Leu Gln Glu Leu Cys Cys Gln His Leu Trp Gln Ile 

                165                 170                 175     





Pro Glu Gln Ser Gln Cys Gln Ala Ile Gln Asn Val Val His Ala Ile 

            180                 185                 190         





Ile Leu His Gln Gln Gln Lys Gln Gln Gln Gln Pro Ser Ser Gln Val 

        195                 200                 205             





Ser Phe Gln Gln Pro Leu Gln Gln Tyr Pro Leu Gly Gln Gly Ser Phe 

    210                 215                 220                 





Arg Pro Ser Gln Gln Asn Pro Gln Asp Gln Gly Ser Val Gln Pro Gln 

225                 230                 235                 240 





Gln Leu Pro Gln Phe Glu Glu Ile Arg Asn Leu Ala Leu Gln Thr Leu 

                245                 250                 255     





Pro Ala Met Cys Asn Val Tyr Ile Pro Pro Tyr Cys Thr Ile Ala Pro 

            260                 265                 270         





Phe Gly Ile Phe Gly Thr Asn 

        275                 





<210>  200

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Mouse (m)MOG-35-55 peptide



<400>  200



Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 

1               5                   10                  15      





Tyr Arg Asn Gly Lys 

            20      





<210>  201

<211>  192

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Extracellular domain of HLA-DRB1*0401 beta chain



<400>  201



Gly Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His 

1               5                   10                  15      





Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr 

            20                  25                  30          





His Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg 

        35                  40                  45              





Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 

    50                  55                  60                  





Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg 

65                  70                  75                  80  





His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr 

                85                  90                  95      





Pro Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His 

            100                 105                 110         





Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu 

        115                 120                 125             





Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser 

    130                 135                 140                 





Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 

145                 150                 155                 160 





Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 

                165                 170                 175     





His Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 

            180                 185                 190         





<210>  202

<211>  181

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Extracellular domain of HLA-DRA1*0101 alpha chain



<400>  202



Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 

1               5                   10                  15      





Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 

            20                  25                  30          





His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 

        35                  40                  45              





Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 

    50                  55                  60                  





Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 

65                  70                  75                  80  





Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 

                85                  90                  95      





Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 

            100                 105                 110         





Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 

        115                 120                 125             





Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 

    130                 135                 140                 





Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 

145                 150                 155                 160 





Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 

                165                 170                 175     





His Trp Glu Phe Asp 

            180     





<210>  203

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  203



Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp 

1               5                   10              





<210>  204

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  204



Ile Ala Pro Val Phe Val Leu Leu Glu 

1               5                   





<210>  205

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  205



Leu Pro Arg Leu Ile Ala Phe Thr Ser Glu His Ser His Phe 

1               5                   10                  





<210>  206

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  206



Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys 

1               5                   10              





<210>  207

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  207



Thr Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp 

1               5                   10                  





<210>  208

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  208



Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly Gly Gly 

1               5                   10                  15  





<210>  209

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  209



Lys His Lys Trp Lys Leu Ser Gly Val Glu Arg Ala Asn Ser Val 

1               5                   10                  15  





<210>  210

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  210



Leu Tyr Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe 

1               5                   10                  15  





<210>  211

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  211



Pro Ser Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg 

1               5                   10                  15  





<210>  212

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  212



Arg Met Met Glu Tyr Gly Thr Thr Met Val Ser Tyr Gln Pro Leu 

1               5                   10                  15  





<210>  213

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  213



Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val 

1               5                   10                  15  





<210>  214

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  214



Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 

1               5                   10              





<210>  215

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  215



Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg 

1               5                   10                  15  





<210>  216

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  216



Ala Thr Asp Leu Leu Pro Ala Cys Asp 

1               5                   





<210>  217

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  217



Phe Asp Arg Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu 

1               5                   10                  15  





<210>  218

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  218



Glu Leu Leu Gln Glu Tyr Asn Trp Glu 

1               5                   





<210>  219

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  219



Glu Tyr Asn Trp Glu Leu Ala Asp Gln 

1               5                   





<210>  220

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  220



Asp Ile Asp Phe Leu Ile Glu Glu Ile 

1               5                   





<210>  221

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  221



Thr Gly His Pro Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp 

1               5                   10                  15  





<210>  222

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  222



Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr 

1               5                   10                  15  





<210>  223

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  223



Tyr Val Thr Leu Lys Lys Met Arg Glu 

1               5                   





<210>  224

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  224



Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser Pro Gly Gly Ala Ile Ser 

1               5                   10                  15      





Asn Met Tyr Ala 

            20  





<210>  225

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  225



Asn Met Tyr Ala Met Met Ile Ala Arg Phe Lys Met Phe Pro Glu Val 

1               5                   10                  15      





Lys Glu Lys Gly 

            20  





<210>  226

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  226



Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg Leu Ile Ala 

1               5                   10                  15      





Phe Thr Ser Glu 

            20  





<210>  227

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  227



Asp Ser Val Ile Leu Ile Lys Cys Asp 

1               5                   





<210>  228

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  228



Gly Lys Met Ile Pro Ser Asp Leu Glu 

1               5                   





<210>  229

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  229



Glu Arg Arg Ile Leu Glu Ala Lys Gln 

1               5                   





<210>  230

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  230



Glu Arg Ala Asn Ser Val Thr Trp Asn 

1               5                   





<210>  231

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  231



Gln Cys Ser Ala Leu Leu Val Arg Glu 

1               5                   





<210>  232

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  232



Lys His Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln 

1               5                   10                  15  





<210>  233

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  233



Ala Lys Gly Thr Thr Gly Phe Glu Ala His Val Asp Lys Cys Leu 

1               5                   10                  15  





<210>  234

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  234



Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Asn Ile Ile Lys 

1               5                   10                  15      





Asn Arg Glu Gly 

            20  





<210>  235

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  235



Ile Ile Lys Asn Arg Glu Gly Tyr Glu 

1               5                   





<210>  236

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  236



Met Val Phe Asp Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp 

1               5                   10                  15  





<210>  237

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  237



Cys Phe Trp Tyr Ile Pro Pro Ser Leu Arg Thr Leu Glu Asp Asn 

1               5                   10                  15  





<210>  238

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  238



Phe Trp Tyr Ile Pro Pro Ser Leu Arg Thr Leu Glu Asp 

1               5                   10              





<210>  239

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  239



Ser Leu Arg Thr Leu Glu Asp Asn Glu 

1               5                   





<210>  240

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  240



Glu Arg Met Ser Arg Leu Ser Lys Val Ala Pro Val Ile Lys Ala 

1               5                   10                  15  





<210>  241

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  241



Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met Val Ser Tyr 

1               5                   10                  15  





<210>  242

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  242



Arg Met Met Glu Tyr Gly Thr Thr Met Val Ser Tyr Gln Pro Leu 

1               5                   10                  15  





<210>  243

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  243



Val Ile Ser Asn Pro Ala Ala Thr His 

1               5                   





<210>  244

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  244



Ile Asp Phe Leu Ile Glu Glu Ile Glu 

1               5                   





<210>  245

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  245



Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu Met 

1               5                   10                  15      





His Cys Gln Thr 

            20  





<210>  246

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  246



Gly His Pro Arg Tyr Phe Asn Gln Leu Ser Thr Gly 

1               5                   10          





<210>  247

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  247



Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Leu Phe Tyr Val Thr Leu 

1               5                   10                  15      





Lys Lys Met Arg 

            20  





<210>  248

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  248



Val Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr His Gln 

1               5                   10                  15      





Asp 

    





<210>  249

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  249



Asp Lys Val Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 

1               5                   10                  15      





His Gln Asp Ile Asp 

            20      





<210>  250

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  250



Phe Phe Arg Met Val Ile Ser Asn Pro Ala 

1               5                   10  





<210>  251

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  251



Leu Thr Ile Gln Ile Glu Ser Ala Ala Asp Gln Asp Pro Ser 

1               5                   10                  





<210>  252

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  252



Arg Thr Gly Ile Ala Gln Ala Leu Ser Ser Phe Asp Leu His 

1               5                   10                  





<210>  253

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  253



Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Gly Ile Met Ile Thr 

1               5                   10                  





<210>  254

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  254



Ile Leu Ser Val His Val Ala Thr Ala Ala Ser Gln Asp Ser 

1               5                   10                  





<210>  255

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  255



Ser Lys Arg Leu Thr Phe Gly Trp Tyr Arg Ala Glu Ile Leu 

1               5                   10                  





<210>  256

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  256



Ala Ile Leu Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr 

1               5                   10                  





<210>  257

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  257



Lys Ala Thr Gly Asn Arg Ser Ser Lys Gln Ala His Ala Lys 

1               5                   10                  





<210>  258

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  258



Ala Val Asp Gly Val Ile Ser Val His Ser Leu His Ile Trp 

1               5                   10                  





<210>  259

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  259



Val Ser Ser Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro 

1               5                   10                  15      





Ser Ser Phe Ser Asp 

            20      





<210>  260

<211>  24

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  260



Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn 

1               5                   10                  15      





Thr Cys Ala Thr Ala Gln Gly Glu 

            20                  





<210>  261

<211>  24

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  261



Lys Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala 

1               5                   10                  15      





Ser Pro Ile Ile Glu His Asp Pro 

            20                  





<210>  262

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  262



Ile Lys Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn 

1               5                   10                  15      





Ala Ser Pro Ile 

            20  





<210>  263

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  263



Met Val Trp Glu Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu 

1               5                   10                  15      





Val Glu Asp Gly Val 

            20      





<210>  264

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  264



Arg Gln His Ala Arg Gln Gln Asp Lys Glu Arg Leu Ala Ala Leu Gly 

1               5                   10                  15      





Pro Glu 

        





<210>  265

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  265



Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe Glu Tyr Gln Asp Leu 

1               5                   10                  15      





Cys Arg 

        





<210>  266

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  266



Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser Val Ser Ser Gln Phe 

1               5                   10                  15      





Ser Asp 

        





<210>  267

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  267



Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His Ser Ser Thr Pro 

1               5                   10                  15      





Ser Trp 

        





<210>  268

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  268



Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys 

1               5                   10                  15      





Lys Asn 

        





<210>  269

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  269



Asn Ala Ser Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile 

1               5                   10                  15      





Ala Thr 

        





<210>  270

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  270



Asp Glu Gly Ser Ala Leu Tyr His Val Tyr Glu Val Asn Leu Val Ser 

1               5                   10                  15      





Glu His 

        





<210>  271

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  271



Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His Val Arg 

1               5                   10                  15      





Asp 

    





<210>  272

<211>  19

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  272



Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala 

1               5                   10                  15      





Leu Pro Gln 

            





<210>  273

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  273



Lys Asn Arg Ser Leu Ala Val Leu Thr Tyr Asp His Ser Arg Ile 

1               5                   10                  15  





<210>  274

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  274



Gly Ala Asp Pro Ser Ala Asp Ala Thr Glu Ala Tyr Gln Glu Leu 

1               5                   10                  15  





<210>  275

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  275



Glu Ile Asp Ile Ala Ala Thr Leu Glu 

1               5                   





<210>  276

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  276



Asn Thr Cys Ala Thr Ala Gln Gly Glu 

1               5                   





<210>  277

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  277



Glu Pro Asn Thr Cys Ala Thr Ala Gln 

1               5                   





<210>  278

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  278



Glu Arg Leu Ala Ala Leu Gly Pro Glu 

1               5                   





<210>  279

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  279



Gln His Ala Arg Gln Gln Asp Lys Glu 

1               5                   





<210>  280

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  280



Tyr Glu Val Asn Leu Val Ser Glu His 

1               5                   





<210>  281

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  281



Gly Ala Ser Leu Tyr His Val Tyr Glu 

1               5                   





<210>  282

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  282



Phe Ala Leu Thr Ala Val Ala Glu Glu 

1               5                   





<210>  283

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  283



Gly Ala His Gly Asp Thr Thr Phe Glu 

1               5                   





<210>  284

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  284



Gly Asp Thr Thr Phe Glu Tyr Gln Asp 

1               5                   





<210>  285

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  285



Ala Ala Gln Ala Ser Pro Ser Ser His 

1               5                   





<210>  286

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  286



Ser Arg Val Ser Ser Val Ser Ser Gln 

1               5                   





<210>  287

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  287



Thr Gln Phe His Phe Leu Ser Trp Pro 

1               5                   





<210>  288

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  288



Glu Glu Pro Ala Gln Ala Asn Met Asp 

1               5                   





<210>  289

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  289



Gly His Met Ile Leu Ala Tyr Met Glu 

1               5                   





<210>  290

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  290



Met Ile Leu Ala Tyr Met Glu Asp His 

1               5                   





<210>  291

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  291



Gln Ala Leu Cys Ala Tyr Gln Ala Glu 

1               5                   





<210>  292

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  292



Glu Trp Gln Ala Leu Cys Ala Tyr Gln 

1               5                   





<210>  293

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  293



Leu Val Arg Ser Lys Asp Gln Phe Glu 

1               5                   





<210>  294

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  294



Val Glu Asp Gly Val Lys Gln Cys Asp 

1               5                   





<210>  295

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  295



Tyr Ile Leu Ile Asp Met Val Leu Asn 

1               5                   





<210>  296

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  296



Glu Ser Gly Cys Thr Val Ile Val Met 

1               5                   





<210>  297

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  297



Leu Cys Ala Tyr Gln Ala Glu Pro Asn 

1               5                   





<210>  298

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  298



Glu Thr Arg Thr Leu Thr Gln Phe His 

1               5                   





<210>  299

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  299



Val Glu Ser Ser Pro Ser Arg Ser Asp 

1               5                   





<210>  300

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  300



Gly Pro Leu Ser His Thr Ile Ala Asp 

1               5                   





<210>  301

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  301



Ser Leu Phe Asn Arg Ala Glu Gly Pro 

1               5                   





<210>  302

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  302



His Pro Asp Phe Leu Pro Tyr Asp His 

1               5                   





<210>  303

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  303



His Phe Leu Ser Trp Pro Ala Glu Gly 

1               5                   





<210>  304

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  304



Asp Phe Arg Arg Lys Val Asn Lys Cys 

1               5                   





<210>  305

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  305



His Cys Ser Asp Gly Ala Gly Arg Thr 

1               5                   





<210>  306

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  306



Leu Val Arg Ser Phe Tyr Leu Lys Asn 

1               5                   





<210>  307

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  307



Lys Asn Arg Ser Leu Ala Val Leu Thr Tyr Asp His Ser Arg Ile 

1               5                   10                  15  





<210>  308

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  308



Gly Ala Asp Pro Ser Ala Asp Ala Thr Glu Ala Tyr Gln Glu Leu 

1               5                   10                  15  





<210>  309

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  309



Ala Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu 

1               5                   10                  15      





<210>  310

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  310



Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn Thr Cys Ala Thr 

1               5                   10                  15      





<210>  311

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  311



Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu Ser Gly 

1               5                   10                  15      





<210>  312

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  312



Asp Phe Trp Gln Met Val Trp Glu Ser Gly Cys Thr Val Ile Val Met 

1               5                   10                  15      





<210>  313

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  313



Trp Glu Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu 

1               5                   10                  15      





<210>  314

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  314



Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly Val Lys Gln Cys 

1               5                   10                  15      





<210>  315

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  315



Ser Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu 

1               5                   10                  15      





<210>  316

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  316



Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln 

1               5                   10                  15      





<210>  317

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  317



Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln 

1               5                   10                  15      





<210>  318

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  318



Asp Phe Arg Arg Lys Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro 

1               5                   10                  15      





<210>  319

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  319



Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala Lys Gly Val Lys 

1               5                   10                  15      





<210>  320

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  320



Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu 

1               5                   10                  15      





<210>  321

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  321



Glu Ala Leu Tyr Leu Val Cys Gly Glu 

1               5                   





<210>  322

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  322



Ser Ile Cys Ser Leu Tyr Gln Leu Glu 

1               5                   





<210>  323

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  323



Ala Leu Leu Ala Leu Trp Gly Pro Asp 

1               5                   





<210>  324

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  324



Gly Ser Leu Gln Pro Leu Ala Leu Glu 

1               5                   





<210>  325

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  325



Thr Pro Lys Thr Arg Arg Glu Ala Glu 

1               5                   





<210>  326

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  326



Pro Ala Ala Ala Phe Val Asn Gln His 

1               5                   





<210>  327

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  327



Asp Pro Ala Ala Ala Phe Val Asn Gln 

1               5                   





<210>  328

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  328



Pro Asp Pro Ala Ala Ala Phe Val Asn 

1               5                   





<210>  329

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  329



Gln Lys Arg Gly Ile Val Glu Gln Cys 

1               5                   





<210>  330

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  330



Glu Leu Gly Gly Gly Pro Gly Ala Gly 

1               5                   





<210>  331

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  331



Glu Ala Glu Asp Leu Gln Val Gly Gln 

1               5                   





<210>  332

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  332



Leu Gln Val Gly Gln Val Glu Leu Gly 

1               5                   





<210>  333

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  333



His Leu Cys Gly Ser His Leu Val Glu 

1               5                   





<210>  334

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  334



Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser 

1               5                   10          





<210>  335

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  335



Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser 

1               5                   10                  





<210>  336

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  336



Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Pro Ala Ala Ala Phe Val 

1               5                   10                  15      





<210>  337

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  337



Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val 

1               5                   10                  15      





<210>  338

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  338



Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly 

1               5                   10                  15  





<210>  339

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  339



Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp 

1               5                   10              





<210>  340

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  340



Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 

1               5                   10                  15      





Arg Gly 

        





<210>  341

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  341



Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 

1               5                   10                  15      





Ser 

    





<210>  342

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  342



Lys Phe Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu 

1               5                   10                  15      





Leu Ala Asp Ala 

            20  





<210>  343

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  343



Asn Pro Val Glu Ile Arg Arg Gly Val Met Leu Ala Val Asp Ala Val 

1               5                   10                  15      





Ile Ala Glu Leu 

            20  





<210>  344

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  344



Gln Ser Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro 

1               5                   10                  15      





Leu Val Ile Ile Ala 

            20      





<210>  345

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  345



Leu Val Leu Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys 

1               5                   10                  15      





Ala Pro Gly Phe 

            20  





<210>  346

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  346



Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile Pro Ala Leu 

1               5                   10                  15      





Asp Ser Leu Thr 

            20  





<210>  347

<211>  24

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  347



Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile Pro Ala Leu Asp 

1               5                   10                  15      





Ser Leu Thr Pro Ala Asn Glu Asp 

            20                  





<210>  348

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  348



Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala Lys 

1               5                   10                  15      





Asn Ala Gly Val 

            20  





<210>  349

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  349



Val Asn Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg 

1               5                   10                  15      





Thr Ala Leu Leu 

            20  





<210>  350

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  350



Met Ala Lys Ala Ala Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 

1               5                   10                  15      





Cys Val Gly Val 

            20  





<210>  351

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  351



Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile 

1               5                   10                  15      





Ala Tyr Gly Leu 

            20  





<210>  352

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  352



Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly Asp Thr 

1               5                   10                  15      





His Leu Gly Gly 

            20  





<210>  353

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  353



Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His Phe 

1               5                   10                  15      





Val Glu Glu Phe 

            20  





<210>  354

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  354



Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser 

1               5                   10                  15      





Leu Phe Glu Gly 

            20  





<210>  355

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  355



Leu Leu Leu Leu Asp Val Ala Pro Leu Ser Leu Gly Leu Glu Thr Ala 

1               5                   10                  15      





Gly Gly Val Met 

            20  





<210>  356

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  356



Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser Asp Asn Gln Pro 

1               5                   10                  15      





Gly Val Leu Ile 

            20  





<210>  357

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  357



Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 

1               5                   10                  15      





Glu Glu Ile Glu 

            20  





<210>  358

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  358



Lys Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala 

1               5                   10                  15      





Glu Asp Glu Val 

            20  





<210>  359

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  359



Gln His Leu Gln Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe 

1               5                   10              





<210>  360

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  360



Arg Val Leu Asn Ile Asp Leu Leu Trp Ser Val Pro Ile 

1               5                   10              





<210>  361

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  361



Tyr Thr Phe Leu Asn Phe Met Ser Asn Val Gly Asp Pro 

1               5                   10              





<210>  362

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  362



Asp Trp Ile His Ile Asp Thr Thr Pro Phe Ala Gly Leu 

1               5                   10              





<210>  363

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  363



Arg Ser Gln Pro Gly Leu Cys Asn Met Tyr Lys Asp Ser His His Pro 

1               5                   10                  15      





Ala Arg Thr Ala 

            20  





<210>  364

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  364



Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu 

1               5                   10                  15      





Gly Gly Arg Asp Ser 

            20      





<210>  365

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  365



Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu 

1               5                   10                  15      





Lys Pro Gly Arg Ser 

            20      





<210>  366

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  366



Arg Ser Gln Pro Gly Leu Cys Asn Met Tyr Lys Asp Ser His His Pro 

1               5                   10                  15      





Ala Arg Thr Ala 

            20  





<210>  367

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  367



Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln 

1               5                   10                  15      





Gly Thr Leu Ser Lys 

            20      





<210>  368

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  368



Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu 

1               5                   10                  15      





Gly Gly Arg Asp Ser 

            20      





<210>  369

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  369



Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln 

1               5                   10                  15      





Gly Thr Leu Ser Lys 

            20      





<210>  370

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  370



Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 

1               5                   10                  15  





<210>  371

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  371



Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn Thr Trp 

1               5                   10                  15      





Thr Thr Cys Gln Ser 

            20      





<210>  372

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  372



Tyr Ile Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro 

1               5                   10                  15      





Ser Lys Thr Ser Ala 

            20      





<210>  373

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  373



Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys Trp Leu Gly 

1               5                   10                  15      





His Pro Asp Lys Phe 

            20      





<210>  374

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  374



Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys 

1               5                   10                  15      





Gly Leu Ser Ala Thr 

            20      





<210>  375

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  375



Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 

1               5                   10                  15      





Arg Gly Thr Lys Phe 

            20      





<210>  376

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  376



Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys Trp Leu Gly 

1               5                   10                  15      





His Pro Asp Lys Phe 

            20      





<210>  377

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  377



Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys 

1               5                   10                  15      





Gly Leu Ser Ala Thr 

            20      





<210>  378

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  378



Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser 

1               5                   10                  15      





Leu Cys Ala Asp 

            20  





<210>  379

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  379



Ser Lys Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met 

1               5                   10                  15      





Tyr Gly Val Leu 

            20  





<210>  380

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  380



Gly Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn 

1               5                   10                  15      





Leu Leu Ser Ile 

            20  





<210>  381

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  381



Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 

1               5                   10                  15      





Arg Gly Thr Lys Phe 

            20      





<210>  382

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  382



Glu Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu 

1               5                   10                  15      





Val Leu Leu Ala Val 

            20      





<210>  383

<211>  20

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  383



Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile Thr Leu 

1               5                   10                  15      





Phe Val Ile Val 

            20  





<210>  384

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  384



Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu Ile Ile Cys Tyr 

1               5                   10                  15      





Asn Trp Leu His Arg 

            20      





<210>  385

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  385



Val Ala Leu Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly 

1               5                   10                  15      





Gln Phe Leu Glu Glu 

            20      





<210>  386

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  386



Gly Phe Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala 

1               5                   10                  15      





Met Glu Leu Lys Val 

            20      





<210>  387

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  387



Ile Thr Val Gly Leu Val Phe Leu Cys Leu Gln Tyr Arg Leu Arg Gly 

1               5                   10                  15      





Lys Leu Arg Ala Glu 

            20      





<210>  388

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  388



Val Ala Leu Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly 

1               5                   10                  15      





Gln Phe Leu Glu Glu 

            20      





<210>  389

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  389



Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu 

1               5                   10                  15      





His Arg Thr Phe Asp 

            20      





<210>  390

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  390



Glu Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu 

1               5                   10                  15      





Val Leu Leu Ala Val 

            20      





<210>  391

<211>  21

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  391



Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu 

1               5                   10                  15      





His Arg Thr Phe Asp 

            20      





<210>  392

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  BirA recognition motif



<400>  392



Leu Gly Gly Ile Phe Glu Ala Met Lys Met Glu Leu Arg Asp 

1               5                   10                  





<210>  393

<211>  25

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  393



Pro Glu Arg Tyr Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu 

1               5                   10                  15      





Gly Lys Val Thr Leu Arg Ile Arg Asn 

            20                  25  





<210>  394

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  394



Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu 

1               5                   10          





<210>  395

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  395



Phe Val Ile Val Pro Val Leu Gly Pro 

1               5                   





<210>  396

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  396



Lys Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro 

1               5                   10              





<210>  397

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  397



Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro 

1               5                   10              





<210>  398

<211>  18

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  398



Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu 

1               5                   10                  15      





Pro Gly 

        





<210>  399

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  399



Gly Val Val Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu 

1               5                   10                  15  





<210>  400

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  400



Leu Ser Gly Leu Pro Ser Gly Gly Glu Val Leu Glu Ile Ser Val 

1               5                   10                  15  





<210>  401

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  401



Ile Ser Gly Leu Pro Ser Gly Gly Asp Asp Leu Glu Thr Ser Thr 

1               5                   10                  15  





<210>  402

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  402



Phe Phe Tyr Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro 

1               5                   10                  15  





<210>  403

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  403



His Ala Tyr Ser Val Thr Gly Ala Glu Glu Val Glu Ser Asn Gly 

1               5                   10                  15  





<210>  404

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  404



Ser Ala Phe Trp Pro Ser Leu Pro Ser Gly Leu Asp Ala Ala Tyr 

1               5                   10                  15  





<210>  405

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  405



Cys Val Asp Thr Arg Ser Gly Asn Cys Tyr Leu Asp Ile Arg Pro 

1               5                   10                  15  





<210>  406

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  406



Val Lys Glu Gly His Ser Pro Pro Asp Asp Val Asp Ile Val Ile 

1               5                   10                  15  





<210>  407

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  407



Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Leu Asp Gly Pro Ser 

1               5                   10                  15  





<210>  408

<211>  17

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  408



Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 

1               5                   10                  15      





Thr 

    





<210>  409

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  409



Leu Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr 

1               5                   10              





<210>  410

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  410



Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr 

1               5                   10          





<210>  411

<211>  14

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  411



Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr 

1               5                   10                  





<210>  412

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  412



Pro Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr 

1               5                   10              





<210>  413

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  413



Gly Ile Ile Gln Pro Gln Gln Pro Ala Gln Leu 

1               5                   10      





<210>  414

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  414



Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln Gln Pro 

1               5                   10              





<210>  415

<211>  12

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  415



Phe Ser Gln Pro Gln Gln Gln Phe Pro Gln Pro Gln 

1               5                   10          





<210>  416

<211>  13

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  416



Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Tyr 

1               5                   10              





<210>  417

<211>  26

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  417



Phe Leu Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Tyr 

1               5                   10                  15      





Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln 

            20                  25      





<210>  418

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  418



Ala Leu Pro Thr Ala Gln Val Pro Thr Asp Pro 

1               5                   10      





<210>  419

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Autoantigenic peptide



<400>  419



Gly Arg Leu Phe Asp Gln Arg Phe Gly Glu Gly 

1               5                   10      





<210>  420

<211>  238

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Green Fluorescent protein



<400>  420



Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Ile Val Pro Val Leu Ile 

1               5                   10                  15      





Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser Val Arg Gly Glu 

            20                  25                  30          





Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile Lys Phe Ile Cys 

        35                  40                  45              





Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 

    50                  55                  60                  





Gly Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu His Met Lys Met 

65                  70                  75                  80  





Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg 

                85                  90                  95      





Thr Ile Phe Phe Gln Asp Asp Gly Lys Tyr Lys Thr Arg Gly Glu Val 

            100                 105                 110         





Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Met 

        115                 120                 125             





Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 

    130                 135                 140                 





Phe Asn Ser His Asn Val Tyr Ile Met Pro Asp Lys Ala Asn Asn Gly 

145                 150                 155                 160 





Leu Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Gly Gly Gly Val 

                165                 170                 175     





Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu Gly Asp Gly Pro 

            180                 185                 190         





Val Leu Ile Pro Ile Asn His Tyr Leu Ser Leu Gln Thr Ala Ile Ser 

        195                 200                 205             





Lys Asp Arg Asn Glu Thr Arg Asp His Met Val Phe Leu Glu Phe Phe 

    210                 215                 220                 





Ser Ala Cys Gly His Thr His Gly Met Asp Glu Leu Tyr Lys 

225                 230                 235             





<210>  421

<211>  489

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Alkaline phosphatase



<400>  421



Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 

1               5                   10                  15      





Pro Val Thr Lys Ala Arg Thr Pro Glu Met Pro Leu Gln Gly Thr Ala 

            20                  25                  30          





Val Asp Gly Gly Gly Gly Ser Met His Ala Ser Leu Glu Val Leu Glu 

        35                  40                  45              





Asn Arg Ala Ala Gln Gly Asp Ile Thr Ala Pro Gly Gly Ala Arg Arg 

    50                  55                  60                  





Leu Thr Gly Asp Gln Thr Ala Ala Leu Arg Asp Ser Leu Ser Asp Lys 

65                  70                  75                  80  





Pro Ala Lys Asn Ile Ile Leu Leu Ile Gly Asp Gly Met Gly Asp Ser 

                85                  90                  95      





Glu Ile Thr Ala Ala Arg Asn Tyr Ala Glu Gly Ala Gly Gly Phe Phe 

            100                 105                 110         





Lys Gly Ile Asp Ala Leu Pro Leu Thr Gly Gln Tyr Thr His Tyr Ala 

        115                 120                 125             





Leu Asn Lys Lys Thr Gly Lys Pro Asp Tyr Val Thr Asp Ser Ala Ala 

    130                 135                 140                 





Ser Ala Thr Ala Trp Ser Thr Gly Val Lys Thr Tyr Asn Gly Ala Leu 

145                 150                 155                 160 





Gly Val Asp Ile His Glu Lys Asp His Pro Thr Ile Leu Glu Met Ala 

                165                 170                 175     





Lys Ala Ala Gly Leu Ala Thr Gly Asn Val Ser Thr Ala Glu Leu Gln 

            180                 185                 190         





Asp Ala Thr Pro Ala Ala Leu Val Ala His Val Thr Ser Arg Lys Cys 

        195                 200                 205             





Tyr Gly Pro Ser Ala Thr Ser Glu Lys Cys Pro Gly Asn Ala Leu Glu 

    210                 215                 220                 





Lys Gly Gly Lys Gly Ser Ile Thr Glu Gln Leu Leu Asn Ala Arg Ala 

225                 230                 235                 240 





Asp Val Thr Leu Gly Gly Gly Ala Lys Thr Phe Ala Glu Thr Ala Thr 

                245                 250                 255     





Ala Gly Glu Trp Gln Gly Lys Thr Leu Arg Glu Gln Ala Gln Ala Arg 

            260                 265                 270         





Gly Tyr Gln Leu Val Ser Asp Ala Ala Ser Leu Asn Ser Val Thr Glu 

        275                 280                 285             





Ala Asn Gln Gln Lys Pro Leu Leu Gly Leu Phe Ala Asp Gly Asn Met 

    290                 295                 300                 





Pro Val Arg Trp Leu Gly Pro Lys Ala Thr Tyr His Gly Asn Ile Asp 

305                 310                 315                 320 





Lys Pro Ala Val Thr Cys Thr Pro Asn Pro Gln Arg Asn Asp Ser Val 

                325                 330                 335     





Pro Thr Leu Ala Gln Met Thr Asp Lys Ala Ile Glu Leu Leu Ser Lys 

            340                 345                 350         





Asn Glu Lys Gly Phe Phe Leu Gln Val Glu Gly Ala Ser Ile Asp Lys 

        355                 360                 365             





Gln Asp His Ala Ala Asn Pro Cys Gly Gln Ile Gly Glu Thr Val Asp 

    370                 375                 380                 





Leu Asp Glu Ala Val Gln Arg Ala Leu Glu Phe Ala Lys Lys Glu Gly 

385                 390                 395                 400 





Asn Thr Leu Val Ile Val Thr Ala Asp His Ala His Ala Ser Gln Ile 

                405                 410                 415     





Val Ala Pro Asp Thr Lys Ala Pro Gly Leu Thr Gln Ala Leu Asn Thr 

            420                 425                 430         





Lys Asp Gly Ala Val Met Val Met Ser Tyr Gly Asn Ser Glu Glu Asp 

        435                 440                 445             





Ser Gln Glu His Thr Gly Ser Gln Leu Arg Ile Ala Ala Tyr Gly Pro 

    450                 455                 460                 





His Ala Ala Asn Val Val Gly Leu Thr Asp Gln Thr Asp Leu Phe Tyr 

465                 470                 475                 480 





Thr Met Lys Ala Ala Leu Gly Leu Lys 

                485                 





<210>  422

<211>  309

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Peroxidase



<400>  422



Met Gln Leu Thr Pro Thr Phe Tyr Asp Asn Ser Cys Pro Asn Val Ser 

1               5                   10                  15      





Asn Ile Val Arg Asp Thr Ile Val Asn Glu Leu Arg Ser Asp Pro Arg 

            20                  25                  30          





Ile Ala Ala Ser Ile Leu Arg Leu His Phe His Asp Cys Phe Val Asn 

        35                  40                  45              





Gly Cys Asp Ala Ser Ile Leu Leu Asp Asn Thr Thr Ser Phe Arg Thr 

    50                  55                  60                  





Glu Lys Asp Ala Phe Gly Asn Ala Asn Ser Ala Arg Gly Phe Pro Val 

65                  70                  75                  80  





Ile Asp Arg Met Lys Ala Ala Val Glu Ser Ala Cys Pro Arg Thr Val 

                85                  90                  95      





Ser Cys Ala Asp Leu Leu Thr Ile Ala Ala Gln Gln Ser Val Thr Leu 

            100                 105                 110         





Ala Gly Gly Pro Ser Trp Arg Val Pro Leu Gly Arg Arg Asp Ser Leu 

        115                 120                 125             





Gln Ala Phe Leu Asp Leu Ala Asn Ala Asn Leu Pro Ala Pro Phe Phe 

    130                 135                 140                 





Thr Leu Pro Gln Leu Lys Asp Ser Phe Arg Asn Val Gly Leu Asn Arg 

145                 150                 155                 160 





Ser Ser Asp Leu Val Ala Leu Ser Gly Gly His Thr Phe Gly Lys Asn 

                165                 170                 175     





Gln Cys Arg Phe Ile Met Asp Arg Leu Tyr Asn Phe Ser Asn Thr Gly 

            180                 185                 190         





Leu Pro Asp Pro Thr Leu Asn Thr Thr Tyr Leu Gln Thr Leu Arg Gly 

        195                 200                 205             





Leu Cys Pro Leu Asn Gly Asn Leu Ser Ala Leu Val Asp Phe Asp Leu 

    210                 215                 220                 





Arg Thr Pro Thr Ile Phe Asp Asn Lys Tyr Tyr Val Asn Leu Glu Glu 

225                 230                 235                 240 





Gln Lys Gly Leu Ile Gln Ser Asp Gln Glu Leu Phe Ser Ser Pro Asn 

                245                 250                 255     





Ala Thr Asp Thr Ile Pro Leu Val Arg Ser Phe Ala Asn Ser Thr Gln 

            260                 265                 270         





Thr Phe Phe Asn Ala Phe Val Glu Ala Met Asp Arg Met Gly Asn Ile 

        275                 280                 285             





Thr Pro Leu Thr Gly Thr Gln Gly Gln Ile Arg Leu Asn Cys Arg Val 

    290                 295                 300                 





Val Asn Ser Asn Ser 

305                 





<210>  423

<211>  286

<212>  PRT

<213>  Artificial sequence



<220>

<223>  His and myc tag containing construct



<400>  423



Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 

1               5                   10                  15      





Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Thr Tyr 

            20                  25                  30          





Lys Ile Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 

        35                  40                  45              





Met Ile Tyr Asp Val Asn Gln Arg Pro Ser Gly Val Ser Asp Arg Phe 

    50                  55                  60                  





Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 

65                  70                  75                  80  





Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Gly 

                85                  90                  95      





Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser 

            100                 105                 110         





Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ala Leu 

        115                 120                 125             





Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 

    130                 135                 140                 





Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 

145                 150                 155                 160 





Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 

                165                 170                 175     





Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 

            180                 185                 190         





Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 

        195                 200                 205             





Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 

    210                 215                 220                 





Ala Arg His Arg Ala Ala Ser Gly Ser Pro Asp Ala Cys Asp Tyr Trp 

225                 230                 235                 240 





Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro 

                245                 250                 255     





Thr Leu Phe Pro Ala Ala Ala His His His His His His Gly Ala Ala 

            260                 265                 270         





Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala 

        275                 280                 285     





<210>  424

<211>  238

<212>  PRT

<213>  Artificial sequence



<220>

<223>  orange fluorescent protein



<400>  424



Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 

1               5                   10                  15      





Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser Val Arg Gly Glu 

            20                  25                  30          





Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile Lys Phe Ile Cys 

        35                  40                  45              





Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 

    50                  55                  60                  





Gly Tyr Gly Ile Leu Cys Phe Ala Arg Tyr Pro Glu His Met Lys Met 

65                  70                  75                  80  





Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg 

                85                  90                  95      





Thr Ile Phe Phe Gln Asp Asp Gly Lys Tyr Lys Thr Arg Gly Glu Val 

            100                 105                 110         





Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Met 

        115                 120                 125             





Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 

    130                 135                 140                 





Phe Asn Ser His Asn Val Tyr Ile Met Pro Asp Lys Ala Asn Asn Gly 

145                 150                 155                 160 





Leu Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Gly Gly Gly Val 

                165                 170                 175     





Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu Gly Asp Gly Pro 

            180                 185                 190         





Val Leu Ile Pro Ile Asn His Tyr Leu Ser Tyr Gln Thr Ala Ile Ser 

        195                 200                 205             





Lys Asp Arg Asn Glu Thr Arg Asp His Met Val Phe Leu Glu Phe Phe 

    210                 215                 220                 





Ser Ala Cys Gly His Thr His Gly Met Asp Glu Leu Tyr Lys 

225                 230                 235             





<210>  425

<211>  1019

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Beta galactosidase



<400>  425



Met Ala Asp Pro Val Val Leu Gln Arg Arg Asp Trp Glu Asn Pro Gly 

1               5                   10                  15      





Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro Phe Ala Ser Trp 

            20                  25                  30          





Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser Gln Gln Leu Arg 

        35                  40                  45              





Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro Ala Pro Glu Ala 

    50                  55                  60                  





Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu Ala Asp Thr Val 

65                  70                  75                  80  





Val Val Pro Ser Asn Trp Gln Met His Gly Tyr Asp Ala Pro Ile Tyr 

                85                  90                  95      





Thr Asn Val Thr Tyr Pro Ile Thr Val Asn Pro Pro Phe Val Pro Thr 

            100                 105                 110         





Glu Asn Pro Thr Gly Cys Tyr Ser Leu Thr Phe Asn Val Asp Glu Ser 

        115                 120                 125             





Trp Leu Gln Glu Gly Gln Thr Arg Ile Ile Phe Asp Gly Val Asn Ser 

    130                 135                 140                 





Ala Phe His Leu Trp Cys Asn Gly Arg Trp Val Gly Tyr Gly Gln Asp 

145                 150                 155                 160 





Ser Arg Leu Pro Ser Glu Phe Asp Leu Ser Ala Phe Leu Arg Ala Gly 

                165                 170                 175     





Glu Asn Arg Leu Ala Val Met Val Leu Arg Trp Ser Asp Gly Ser Tyr 

            180                 185                 190         





Leu Glu Asp Gln Asp Met Trp Arg Met Ser Gly Ile Phe Arg Asp Val 

        195                 200                 205             





Ser Leu Leu His Lys Pro Thr Thr Gln Ile Ser Asp Phe His Val Ala 

    210                 215                 220                 





Thr Arg Phe Asn Asp Asp Phe Ser Arg Ala Val Leu Glu Ala Glu Val 

225                 230                 235                 240 





Gln Met Cys Gly Glu Leu Arg Asp Tyr Leu Arg Val Thr Val Ser Leu 

                245                 250                 255     





Trp Gln Gly Glu Thr Gln Val Ala Ser Gly Thr Ala Pro Phe Gly Gly 

            260                 265                 270         





Glu Ile Ile Asp Glu Arg Gly Gly Tyr Ala Asp Arg Val Thr Leu Arg 

        275                 280                 285             





Leu Asn Val Glu Asn Pro Lys Leu Trp Ser Ala Glu Ile Pro Asn Leu 

    290                 295                 300                 





Tyr Arg Ala Val Val Glu Leu His Thr Ala Asp Gly Thr Leu Ile Glu 

305                 310                 315                 320 





Ala Glu Ala Cys Asp Val Gly Phe Arg Glu Val Arg Ile Glu Asn Gly 

                325                 330                 335     





Leu Leu Leu Leu Asn Gly Lys Pro Leu Leu Ile Arg Gly Val Asn Arg 

            340                 345                 350         





His Glu His His Pro Leu His Gly Gln Val Met Asp Glu Gln Thr Met 

        355                 360                 365             





Val Gln Asp Ile Leu Leu Met Lys Gln Asn Asn Phe Asn Ala Val Arg 

    370                 375                 380                 





Cys Ser His Tyr Pro Asn His Pro Leu Trp Tyr Thr Leu Cys Asp Arg 

385                 390                 395                 400 





Tyr Gly Leu Tyr Val Val Asp Glu Ala Asn Ile Glu Thr His Gly Met 

                405                 410                 415     





Val Pro Met Asn Arg Leu Thr Asp Asp Pro Arg Trp Leu Pro Ala Met 

            420                 425                 430         





Ser Glu Arg Val Thr Arg Met Val Gln Arg Asp Arg Asn His Pro Ser 

        435                 440                 445             





Val Ile Ile Trp Ser Leu Gly Asn Glu Ser Gly His Gly Ala Asn His 

    450                 455                 460                 





Asp Ala Leu Tyr Arg Trp Ile Lys Ser Val Asp Pro Ser Arg Pro Val 

465                 470                 475                 480 





Gln Tyr Glu Gly Gly Gly Ala Asp Thr Thr Ala Thr Asp Ile Ile Cys 

                485                 490                 495     





Pro Met Tyr Ala Arg Val Asp Glu Asp Gln Pro Phe Pro Ala Val Pro 

            500                 505                 510         





Lys Trp Ser Ile Lys Lys Trp Leu Ser Leu Pro Gly Glu Thr Arg Pro 

        515                 520                 525             





Leu Ile Leu Cys Glu Tyr Ala His Ala Met Gly Asn Ser Leu Gly Gly 

    530                 535                 540                 





Phe Ala Lys Tyr Trp Gln Ala Phe Arg Gln Tyr Pro Arg Leu Gln Gly 

545                 550                 555                 560 





Gly Phe Val Trp Asp Trp Val Asp Gln Ser Leu Ile Lys Tyr Asp Glu 

                565                 570                 575     





Asn Gly Asn Pro Trp Ser Ala Tyr Gly Gly Asp Phe Gly Asp Thr Pro 

            580                 585                 590         





Asn Asp Arg Gln Phe Cys Met Asn Gly Leu Val Phe Ala Asp Arg Thr 

        595                 600                 605             





Pro His Pro Ala Leu Thr Glu Ala Lys His Gln Gln Gln Phe Phe Gln 

    610                 615                 620                 





Phe Arg Leu Ser Gly Gln Thr Ile Glu Val Thr Ser Glu Tyr Leu Phe 

625                 630                 635                 640 





Arg His Ser Asp Asn Glu Leu Leu His Trp Met Val Ala Leu Asp Gly 

                645                 650                 655     





Lys Pro Leu Ala Ser Gly Glu Val Pro Leu Asp Val Ala Pro Gln Gly 

            660                 665                 670         





Lys Gln Leu Ile Glu Leu Pro Glu Leu Pro Gln Pro Glu Ser Ala Gly 

        675                 680                 685             





Gln Leu Trp Leu Thr Val Arg Val Val Gln Pro Asn Ala Thr Ala Trp 

    690                 695                 700                 





Ser Glu Ala Gly His Ile Ser Ala Trp Gln Gln Trp Arg Leu Ala Glu 

705                 710                 715                 720 





Asn Leu Ser Val Thr Leu Pro Ala Ala Ser His Ala Ile Pro His Leu 

                725                 730                 735     





Thr Thr Ser Glu Met Asp Phe Cys Ile Glu Leu Gly Asn Lys Arg Trp 

            740                 745                 750         





Gln Phe Asn Arg Gln Ser Gly Phe Leu Ser Gln Met Trp Ile Gly Asp 

        755                 760                 765             





Lys Lys Gln Leu Leu Thr Pro Leu Arg Asp Gln Phe Thr Arg Ala Pro 

    770                 775                 780                 





Leu Asp Asn Asp Ile Gly Val Ser Glu Ala Thr Arg Ile Asp Pro Asn 

785                 790                 795                 800 





Ala Trp Val Glu Arg Trp Lys Ala Ala Gly His Tyr Gln Ala Glu Ala 

                805                 810                 815     





Ala Leu Leu Gln Cys Thr Ala Asp Thr Leu Ala Asp Ala Val Leu Ile 

            820                 825                 830         





Thr Thr Ala His Ala Trp Gln His Gln Gly Lys Thr Leu Phe Ile Ser 

        835                 840                 845             





Arg Lys Thr Tyr Arg Ile Asp Gly Ser Gly Gln Met Ala Ile Thr Val 

    850                 855                 860                 





Asp Val Glu Val Ala Ser Asp Thr Pro His Pro Ala Arg Ile Gly Leu 

865                 870                 875                 880 





Asn Cys Gln Leu Ala Gln Val Ala Glu Arg Val Asn Trp Leu Gly Leu 

                885                 890                 895     





Gly Pro Gln Glu Asn Tyr Pro Asp Arg Leu Thr Ala Ala Cys Phe Asp 

            900                 905                 910         





Arg Trp Asp Leu Pro Leu Ser Asp Met Tyr Thr Pro Tyr Val Phe Pro 

        915                 920                 925             





Ser Glu Asn Gly Leu Arg Cys Gly Thr Arg Glu Leu Asn Tyr Gly Pro 

    930                 935                 940                 





His Gln Trp Arg Gly Asp Phe Gln Phe Asn Ile Ser Arg Tyr Ser Gln 

945                 950                 955                 960 





Gln Gln Leu Met Glu Thr Ser His Arg His Leu Leu His Ala Glu Glu 

                965                 970                 975     





Gly Thr Trp Leu Asn Ile Asp Gly Phe His Met Gly Ile Gly Gly Asp 

            980                 985                 990         





Asp Ser Trp Ser Pro Ser Val Ser  Ala Asp Phe Gln Leu  Ser Ala Gly 

        995                 1000                 1005             





Arg Tyr  His Tyr Gln Leu Val  Trp Cys Gln Lys 

    1010                 1015                 





<210>  426

<211>  159

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Streptavidin



<400>  426



Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala Gly 

1               5                   10                  15      





Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val Thr 

            20                  25                  30          





Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val Gly 

        35                  40                  45              





Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala Pro 

    50                  55                  60                  





Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp Lys 

65                  70                  75                  80  





Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln Tyr 

                85                  90                  95      





Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr Ser 

            100                 105                 110         





Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His Asp 

        115                 120                 125             





Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala Lys 

    130                 135                 140                 





Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 

145                 150                 155                 





<210>  427

<211>  717

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Green Fluorescent protein coding sequence



<400>  427

atgagtaaag gagaagaact tttcactggg attgtcccag ttctcattga gttagacggt       60



gatgtccatg gacataaatt ctctgtcaga ggagaagggg aaggcgatgc agattatgga      120



aaacttgaaa tcaaattcat ttgcactact ggaaagctac cagttccatg gccaacactt      180



gttactacac tgggctacgg catccaatgt ttcgcaagat acccagaaca catgaaaatg      240



aatgacttct tcaagagtgc catgcctgag ggttacattc aagaaagaac catctttttc      300



caagatgatg gaaaatacaa gacacgtggt gaagtcaagt ttgaaggtga tactcttgtt      360



aacagaattg agctcaaagg tatggacttt aaagaagatg gcaatatcct tggacacaag      420



ttggagtaca attttaattc acataatgta tacattatgc cggacaaagc caataatgga      480



ctcaaagtca atttcaaaat tagacacaat atcgaaggtg gtggtgtcca acttgctgat      540



cattaccaaa caaatgttcc ccttggagac ggtcctgtcc ttataccaat caatcactac      600



ctatccttgc aaacagccat ttcaaaagat cgaaatgaga cgagagatca tatggtgttt      660



ctggaatttt tctcagcttg tggacataca catggcatgg atgaactata caaataa         717





<210>  428

<211>  7151

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Alkaline phosphatase coding sequence



<400>  428

gaattccgga tgagcattca tcaggcgggc aagaatgtga ataaaggccg gataaaactt       60



gtgcttattt ttctttacgg tctttaaaaa ggccgtaata tccagctgaa cggtctggtt      120



ataggtacat tgagcaactg actgaaatgc ctcaaaatgt tctttacgat gccattggga      180



tatatcaacg gtggtatatc cagtgatttt tttctccatt ttagcttcct tagctcctga      240



aaatctcgat aactcaaaaa atacgcccgg tagtgatctt atttcattat ggtgaaagtt      300



ggaacctctt acgtgccgat caacgtctca ttttcgccaa aagttggccc agggcttccc      360



ggtatcaaca gggacaccag gatttattta ttctgcgaag tgatcttccg tcacaggtat      420



ttattcggcg caaagtgcgt cgggtgatgc tgccaactta ctgatttagt gtatgatggt      480



gtttttgagg tgctccagtg gcttctgttt ctatcagctg tccctcctgt tcagctactg      540



acggggtggt gcgtaacggc aaaagcaccg ccggacatca gcgctagcgg agtgtatact      600



ggcttactat gttggcactg atgagggtgt cagtgaagtg cttcatgtgg caggagaaaa      660



aaggctgcac cggtgcgtca gcagaatatg tgatacagga tatattccgc ttcctcgctc      720



actgactcgc tacgctcggt cgttcgactg cggcgagcgg aaatggctta cgaacggggc      780



ggagatttcc tggaagatgc caggaagata cttaacaggg aagtgagagg gccgcggcaa      840



agccgttttt ccataggctc cgcccccctg acaagcatca cgaaatctga cgctcaaatc      900



agtggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggcggctccc      960



tcgtgcgctc tcctgttcct gcctttcggt ttaccggtgt cattccgctg ttatggccgc     1020



gtttgtctca ttccacgcct gacactcagt tccgggtagg cagttcgctc caagctggac     1080



tgtatgcacg aaccccccgt tcagtccgac cgctgcgcct tatccggtaa ctatcgtctt     1140



gagtccaacc cggaaagaca tgcaaaagca ccactggcag cagccactgg taattgattt     1200



agaggagtta gtcttgaagt catgcgccgg ttaaggctaa actgaaagga caagttttgg     1260



tgactgcgct cctccaagcc agttacctcg gttcaaagag ttggtagctc agagaacctt     1320



cgaaaaaccg ccctgcaagg cggttttttc gttttcagag caagagatta cgcgcagacc     1380



aaaacgatct caagaagatc atcttattaa tcagataaaa tatttctaga tttcagtgca     1440



atttatctct tcaaatgtag cacctgaagt cagccccata cgatataagt tgtaattctc     1500



atgtttgaca gcttatcatc gataagcttt tttcgccagg cgcagacttg ctgttcttca     1560



ggcaatcact catgtaggtc ttacgagcat cccctttcaa cgcctgcgcc gtcgcctgct     1620



gattacagga ggtcatacgc tgttgttgtg gggttaaagt tctctcggca gcgccgacgg     1680



tggttaaaaa aaccagaccg aaaagcaagg taaccagtaa tgttattttc atagcaccat     1740



ccctcttcat gttttaacca tgagcgtatg cgcccgtgat ctgccattaa gtctggttgc     1800



taacagcaaa aaaaccaccc ggcagcgaaa attcactgcc gggcgcggtt ttatttcagc     1860



cccagagcgg ctttcatggt gtagaagaga tcggtctggt cggtcagtcc aacaacattg     1920



gcggcatgcg ggccatacgc cgcaatacgc aactgactgc cggtatgttc ttgtgaatcc     1980



tcttcggagt tcccgtaact catcaccatc actgcgccat ctttggtatt tagcgcctgg     2040



gtgaggcccg gagctttggt atccggcgca acaatctggc tggcgtgggc gtgatcagcg     2100



gtgactatga ccagcgtgtt accctccttt ttagcgaatt ccagcgcccg ttgtacggct     2160



tcatcgagat cgaccgtctc gccaatttgc ccacaaggat tcgcagcatg atcctgttta     2220



tcgattgacg caccttcaac ttgcaggaaa aagcctttct catttttact caacaattca     2280



atggctttgt cggtcatctg cgccagggtt ggtacactgt cattacgttg cggatttggc     2340



gtacaggtga ctgcgggctt atcgatattg ccatggtacg ttgctttcgg tcctagccag     2400



cgcactggca tattgccgtc agcaaacagg ccaagcaggg gtttttgctg attcgcttcc     2460



gtcaccgaat tcagtgaggc agcatcgctc accaactgat aaccacgcgc ctgtgcctgt     2520



tcacgcagcg tttttccctg ccattcacca gcggttgccg tttcagcaaa ggtttttgcg     2580



ccgccgccaa gcgtaacgtc ggcacgagcg ttaagcagct gttcggtaat cgatcctttt     2640



ccgccttttt ccagagcgtt acccggacat ttttcactgg tcgcgctcgg accgtagcat     2700



ttgcgcgagg tcacatgtgc caccagcgca gcgggcgtgg catcctgcaa ctctgcggta     2760



gaaacgttac cggtcgccag acctgcggct tttgccattt ccagaatcgt tgggtgatct     2820



ttttcgtgaa tatcgacgcc cagcgcgccg ttataggttt tgacaccggt tgaccaggcg     2880



gttgctgatg cagccgagtc ggtgacgtag tccggtttgc cggttttttt attcagcgca     2940



tagtgagtgt attgcccggt aagcggtaag gcatctatac ctttaaaaaa gccgcccgca     3000



ccttcggcat aattacgtgc ggcagtaatt tccgagtccc ccatcccatc gccaatcagc     3060



aaaataatat tttttgcagg tttatcgcta agagaatcac gcagagcggc agtctgatca     3120



cccgttaaac ggcgagcacc gccgggtgca gtaatatcgc cctgagcagc ccggttttcc     3180



agaacctcga ggctagcatg catagaaccg ccaccaccgt cgacagcggt accctgcaga     3240



ggcatttctg gtgtccgggc ttttgtcaca ggggtaaaca gtaacggtaa gagtgccagt     3300



gcaatagtgc tttgtttcac tttattttct ccatgtcgcg tcttatcagg gggaattctg     3360



tttcctgtgt gaaattgtta tccgctcaca attccacaca ttatacgagc cgatgattaa     3420



ttgtcaacag ctcatttcag aatatttgcc agaaccgtta tgatgtcggc gcaaaaaaca     3480



ttatctagag gggaattgtt atccgctcac aattccccta tagtgagtcg tattaatttc     3540



gcgggatcga gatctcgatc ctctacgccg gacgcatcgt ggccggcatc accggcgcca     3600



caggtgcggt tgctggcgcc tatatcgccg acatcaccga tggggaagat cgggctcgcc     3660



acttcgggct catgagcgct tgtttcggcg tgggtatggt ggcaggcccc gtggccgggg     3720



gactgttggg cgccatctcc ttgcatgcac cattccttgc ggcggcggtg ctcaacggcc     3780



tcaacctact actgggctgc ttcctaatgc aggagtcgca taagggagag cgtcgagatc     3840



ccggacacca tcgaatggcg caaaaccttt cgcggtatgg catgatagcg cccggaagag     3900



agtcaattca gggtggtgaa tgtgaaacca gtaacgttat acgatgtcgc agagtatgcc     3960



ggtgtctctt atcagaccgt ttcccgcgtg gtgaaccagg ccagccacgt ttctgcgaaa     4020



acgcgggaaa aagtggaagc ggcgatggcg gagctgaatt acattcccaa ccgcgtggca     4080



caacaactgg cgggcaaaca gtcgttgctg attggcgttg ccacctccag tctggccctg     4140



cacgcgccgt cgcaaattgt cgcggcgatt aaatctcgcg ccgatcaact gggtgccagc     4200



gtggtggtgt cgatggtaga acgaagcggc gtcgaagcct gtaaagcggc ggtgcacaat     4260



cttctcgcgc aacgcgtcag tgggctgatc attaactatc cgctggatga ccaggatgcc     4320



attgctgtgg aagctgcctg cactaatgtt ccggcgttat ttcttgatgt ctctgaccag     4380



acacccatca acagtattat tttctcccat gaagacggta cgcgactggg cgtggagcat     4440



ctggtcgcat tgggtcacca gcaaatcgcg ctgttagcgg gcccattaag ttctgtctcg     4500



gcgcgtctgc gtctggctgg ctggcataaa tatctcactc gcaatcaaat tcagccgata     4560



gcggaacggg aaggcgactg gagtgccatg tccggttttc aacaaaccat gcaaatgctg     4620



aatgagggca tcgttcccac tgcgatgctg gttgccaacg atcagatggc gctgggcgca     4680



atgcgcgcca ttaccgagtc cgggctgcgc gttggtgcgg atatctcggt agtgggatac     4740



gacgataccg aagacagctc atgttatatc ccgccgttaa ccaccatcaa acaggatttt     4800



cgcctgctgg ggcaaaccag cgtggaccgc ttgctgcaac tctctcaggg ccaggcggtg     4860



aagggcaatc agctgttgcc cgtctcactg gtgaaaagaa aaaccaccct ggcgcccaat     4920



acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt     4980



tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtaagttagc tcactcatta     5040



ggcaccggga tctcgaccga tgcccttgag agccttcaac ccagtcagct ccttccggtg     5100



ggcgcggggc atgactatcg tcgccgcact tatgactgtc ttctttatca tgcaactcgt     5160



aggacaggtg ccggcagcgc tctgggtcat tttcggcgag gaccgctttc gctggagcgc     5220



gacgatgatc ggcctgtcgc ttgcggtatt cggaatcttg cacgccctcg ctcaagcctt     5280



cgtcactggt cccgccacca aacgtttcgg cgagaagcag gccattatcg ccggcatggc     5340



ggccgacgcg ctgggctacg tcttgctggc gttcgcgacg cgaggctgga tggccttccc     5400



cattatgatt cttctcgctt ccggcggcat cgggatgccc gcgttgcagg ccatgctgtc     5460



caggcaggta gatgacgacc atcagggaca gcttcaagga tcgctcgcgg ctcttaccag     5520



cctaacttcg atcactggac cgctgatcgt cacggcgatt tatgccgcct cggcgagcac     5580



atggaacggg ttggcatgga ttgtaggcgc cgccctatac cttgtctgcc tccccgcgtt     5640



gcgtcgcggt gcatggagcc gggccacctc gacctgaatg gaagccggcg gcacctcgct     5700



aacggattca ccactccaag aattggagcc aatcaattct tgcggagaac tgtgaatgcg     5760



caaaccaacc cttggcagaa catatccatc gcgtccgcca tctccagcag ccgcacgcgg     5820



cgcatctcgg gcagcgttgg gtcctggcca cgggtgcgca tgatcgtgct cctgtcgttg     5880



aggacccggc taggctggcg gggttgcctt actggttagc agaatgaatc accgatacgc     5940



gagcgaacgt gaagcgactg ctgctgcaaa acgtctgcga cctgagcaac aacatgaatg     6000



gtcttcggtt tccgtgtttc gtaaagtctg gaaacgcgga agtcccctac gtgctgctga     6060



agttgcccgc aacagagagt ggaaccaacc ggtgatacca cgatactatg actgagagtc     6120



aacgccatga gcggcctcat ttcttattct gagttacaac agtccgcacc gctgtccggt     6180



agctccttcc ggtgggcgcg gggcatgact atcgtcgccg cacttatgac tgtcttcttt     6240



atcatgcaac tcgtaggaca ggtgccggca gcgcccaaca gtcccccggc cacggggcct     6300



gccaccatac ccacgccgaa acaagcgccc tgcaccatta tgttccggat ctgcatcgca     6360



ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg ctaaccgttt     6420



ttatcaggct ctgggaggca gaataaatga tcatatcgtc aattattacc tccacgggga     6480



gagcctgagc aaactggcct caggcatttg agaagcacac ggtcacactg cttccggtag     6540



tcaataaacc ggtaaaccag caatagacat aagcggctat ttaacgaccc tgccctgaac     6600



cgacgaccgg gtcgaatttg ctttcgaatt tctgccattc atccgcttat tatcacttat     6660



tcaggcgtag caccaggcgt ttaagggcac caataactgc cttaaaaaaa ttacgccccg     6720



ccctgccact catcgcagta ctgttgtaat tcattaagca ttctgccgac atggaagcca     6780



tcacagacgg catgatgaac ctgaatcgcc agcggcatca gcaccttgtc gccttgcgta     6840



taatatttgc ccatggtgaa aacgggggcg aagaagttgt ccatattggc cacgtttaaa     6900



tcaaaactgg tgaaactcac ccagggattg gctgagacga aaaacatatt ctcaataaac     6960



cctttaggga aataggccag gttttcaccg taacacgcca catcttgcga atatatgtgt     7020



agaaactgcc ggaaatcgtc gtggtattca ctccagagcg atgaaaacgt ttcagtttgc     7080



tcatggaaaa cggtgtaaca agggtgaaca ctatcccata tcaccagctc accgtctttc     7140



attgccatac g                                                          7151





<210>  429

<211>  955

<212>  DNA

<213>  Artificial sequence



<220>

<223>  peroxidase coding sequence



<400>  429

aagcttaacc atgcagttaa cccctacatt ctacgacaat agctgtccca acgtgtccaa       60



catcgttcgc gacacaatcg tcaacgagct cagatccgat cccaggatcg ctgcttcaat      120



attacgtctg cacttccatg actgcttcgt gaatggttgc gacgctagca tattactgga      180



caacaccacc agtttccgca ctgaaaagga tgcattcggg aacgctaaca gcgccagggg      240



ctttccagtg atcgatcgca tgaaggctgc cgttgagtca gcatgcccac gaacagtcag      300



ttgtgcagac ctgctgacta tagctgcgca acagagcgtg actcttgcag gcggaccgtc      360



ctggagagtg ccgctcggtc gacgtgactc cctacaggca ttcctagatc tggccaacgc      420



caacttgcct gctccattct tcaccctgcc ccagctgaag gatagcttta gaaacgtggg      480



tctgaatcgc tcgagtgacc ttgtggctct gtccggagga cacacatttg gaaagaacca      540



gtgtaggttc atcatggata ggctctacaa tttcagcaac actgggttac ctgaccccac      600



gctgaacact acgtatctcc agacactgag aggcttgtgc ccactgaatg gcaacctcag      660



tgcactagtg gactttgatc tgcggacccc aaccatcttc gataacaagt actatgtgaa      720



tctagaggag cagaaaggcc tgatacagag tgatcaagaa ctgtttagca gtccaaacgc      780



cactgacacc atcccactgg tgagaagttt tgctaactct actcaaacct tctttaacgc      840



cttcgtggaa gccatggacc gtatgggtaa cattacccct ctgacgggta cccaaggcca      900



gattcgtctg aactgcagag tggtcaacag caactcttaa taaggatccg aattc           955





<210>  430

<211>  861

<212>  DNA

<213>  Artificial sequence



<220>

<223>  His and myc tag containing construct



<400>  430

cagtctgtgt tgacgcagcc gccctcagtg tctgggtctc ctggacagtc gatcaccatc       60



tcctgcactg gaaccagcag tgatattggg acttataaaa ttgtctcctg gtaccaacag      120



caccctggca aagcccccaa actcatgatt tatgacgtca atcagcggcc ctcaggggtt      180



tctgatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240



caggctgagg acgaggctga ttattactgc agctcatata caagcggcag cactctggta      300



ttcggcgggg ggaccaagct gaccgtccta ggctcgagtg gtggaggcgg ttcaggcgga      360



ggtggctctg gcggtagtgc acttcaggta cagctgcagc agtcaggagc agaggtgaaa      420



aagcccgggg agtctctgaa gatctcctgt aagggttctg gatacagctt taccagctac      480



tggatcggct gggtgcgcca gatgcccggg aaaggcctgg agtggatggg gatcatctat      540



cctggtgact ctgataccag atacagcccg tccttccaag gccaggtcac catctcagcc      600



gacaagtcca tcagcaccgc ctacctgcag tggagcagcc tgaaggcctc ggacaccgcc      660



atgtattact gtgcgagaca tcgggccgct agtgggagcc cggacgcgtg tgactactgg      720



ggccagggaa ccctggtcac cgtctcctca gggagtgcat ccgccccaac ccttttcccc      780



gcggccgcac atcatcatca ccatcacggg gccgcagaac aaaaactcat ctcagaagag      840



gatctgaatg gggccgcata g                                                861





<210>  431

<211>  717

<212>  DNA

<213>  Artificial sequence



<220>

<223>  orange fluorescent protein coding sequence



<400>  431

atgagtaaag gagaagaact tttcactgga gttgtcccaa ttcttgttga attagatggt       60



gatgtccatg gacataaatt ctctgtcaga ggagaagggg aaggcgatgc agattatgga      120



aaacttgaaa tcaaattcat ttgcactact ggaaagctac cagttccatg gccaacactt      180



gttactacac tgggctatgg catcctatgt ttcgcaagat acccagaaca catgaaaatg      240



aatgacttct tcaagagtgc catgcctgag ggttacattc aagaaagaac catctttttc      300



caagatgatg gaaaatacaa gacacgtggt gaagtcaagt ttgaaggtga tactcttgtt      360



aacagaattg agctcaaagg tatggacttt aaagaagatg gcaatatcct tggacacaag      420



ttggagtaca attttaactc acataatgta tacattatgc cggacaaagc caataatgga      480



ctcaaagtca atttcaaaat tagacacaat atcgaaggtg gtggtgtcca actcgctgat      540



cattaccaaa caaatgttcc ccttggagac ggtcctgtcc ttataccaat caatcactac      600



ctatcctatc aaacagccat ttcaaaagat cgaaatgaga cgagagatca tatggtgttt      660



ctggaatttt tctcagcttg tggacataca catggcatgg atgaactata caaataa         717





<210>  432

<211>  8388

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Beta galactosidase coding sequence



<400>  432

acgttaaggg attttggtca tggacggcca gcaggtaggc cgacaggctc atgccggccg       60



ccgccgcctt ttcctcaatc gctcttcgtt cgtctggaag gcagtacacc ttgataggtg      120



ggctgccctt cctggttggc ttggtttcat cagccatccg cttgccctca tctgttacgc      180



cggcggtagc cggccagcct cgcagagcag gattcccgtt gagcaccgcc aggtgcgaat      240



aagggacagt gaagaaggaa cacccgctcg cgggtgggcc tacttcacct atcctgcccg      300



gctgacgccg ttggatacac caaggaaagt ctacacgaac cctttggcaa aatcctgtat      360



atcgtgcgaa aaaggatgga tataccgaaa aaatcgctat aatgaccccg aagcagggtt      420



atgcagcgga aaagcgctgc ttccctgctg ttttgtggaa tatctaccga ctggaaacag      480



gcaaatgcag gaaattactg aactgagggg acaggcgaga gacgatgcca aagagctaca      540



ccgacgagct ggccgagtgg gttgaatccc gcgcggccaa gaagcgccgg cgtgatgagg      600



ctgcggttgc gttcctggcg gtgagggcgg atgtcgatat gcgtaaggag aaaataccgc      660



atcaggcgca tatttgaatg tatttagaaa aataaacaaa aagagtttgt agaaacgcaa      720



aaaggccatc cgtcaggatg gccttctgct taatttgatg cctggcagtt tatggcgggc      780



gtcctgcccg ccaccctccg ggccgttgct tcgcaacgtt caaatccgct cccggcggat      840



ttgtcctact caggagagcg ttcaccgaca aacaacagat aaaacgaaag gcccagtctt      900



tcgactgagc ctttcgtttt atttgatgcc tggcagttcc ctactctcgc atggggagac      960



cccacactac catcggcgct acggcgtttc acttctgagt tcggcatggg gtcaggtggg     1020



accaccgcgc tactgccgcc aggcaaattc tgttttatca gaccgcttct gcgttctgat     1080



ttaatctgta tcaggctgaa aattaaggaa tcccccagga cccaacgctg cccgagtttg     1140



tcagaaagca gaccaaacag cggttggaat aatagcgaga acagagaaat agcggcaaaa     1200



ataatacccg tatcactttt gctgatatgg ttgatgtcat gtagccaaat cgggaaaaac     1260



gggaagtagg ctcccatgat aaaaaagtaa aagaaaaaga ataaaccgaa catccaaaag     1320



tttgtgtttt ttaaatagta cataatggat ttccttacgc gaaatacggg cagacatggc     1380



ctgcccggtt attattattt ttgacaccag accaactggt aatggtagcg accggcgctc     1440



agctggaaat ccgccgatac tgacgggctc caggagtcgt cgccaccaat ccccatatgg     1500



aaaccgtcga tattcagcca tgtgccttct tccgcgtgca gcagatggcg atggctggtt     1560



tccatcagtt gctgttgact gtagcggctg atgttgaact ggaagtcgcc gcgccactgg     1620



tgtgggccat aattcaattc gcgcgtcccg cagcgcagac cgttttcgct cgggaagacg     1680



tacggggtat acatgtctga caatggcaga tcccagcggt caaaacaggc ggcagtaagg     1740



cggtcgggat agttttcttg cggccctaat ccgagccagt ttacccgctc tgctacctgc     1800



gccagctggc agttcaggcc aatccgcgcc ggatgcggtg tatcgctcgc cacttcaaca     1860



tcaacggtaa tcgccatttg accactacca tcaatccggt aggttttccg gctgataaat     1920



aaggttttcc cctgatgctg ccacgcgtga gcggtcgtaa tcagcaccgc atcagcaagt     1980



gtatctgccg tgcactgcaa caacgctgct tcggcctggt aatggcccgc cgccttccag     2040



cgttcgaccc aggcgttagg gtcaatgcgg gtcgcttcac ttacgccaat gtcgttatcc     2100



agcggtgcac gggtgaactg atcgcgcagc ggcgtcagca gttgtttttt atcgccaatc     2160



cacatctgtg aaagaaagcc tgactggcgg ttaaattgcc aacgcttatt acccagctcg     2220



atgcaaaaat ccatttcgct ggtggtcaga tgcgggatgg cgtgggacgc ggcggggagc     2280



gtcacactga ggttttccgc cagacgccac tgctgccagg cgctgatgtg cccggcttct     2340



gaccatgcgg tcgcgttcgg ttgcactacg cgtactgtga gccagagttg cccggcgctc     2400



tccggctgcg gtagttcagg cagttcaatc aactgtttac cttgtggagc gacatccaga     2460



ggcacttcac cgcttgccag cggcttacca tccagcgcca ccatccagtg caggagctcg     2520



ttatcgctat gacggaacag gtattcgctg gtcacttcga tggtttgccc ggataaacgg     2580



aactggaaaa actgctgctg gtgttttgct tccgtcagcg ctggatgcgg cgtgcggtcg     2640



gcaaagacca gaccgttcat acagaactgg cgatcgttcg gcgtatcgcc aaaatcaccg     2700



ccgtaagccg accacgggtt gccgttttca tcatatttaa tcagcgactg atccacccag     2760



tcccagacga agccgccctg taaacgggga tactgacgaa acgcctgcca gtatttagcg     2820



aaaccgccaa gactgttacc catcgcgtgg gcgtattcgc aaaggatcag cgggcgcgtc     2880



tctccaggta gcgaaagcca ttttttgatg gaccatttcg gcacagccgg gaagggctgg     2940



tcttcatcca cgcgcgcgta catcgggcaa ataatatcgg tggccgtggt gtcggctccg     3000



ccgccttcat actgcaccgg gcgggaagga tcgacagatt tgatccagcg atacagcgcg     3060



tcgtgattag cgccgtggcc tgattcattc cccagcgacc agatgatcac actcgggtga     3120



ttacgatcgc gctgcaccat tcgcgttacg cgttcgctca tcgccggtag ccagcgcgga     3180



tcatcggtca gacgattcat tggcaccatg ccgtgggttt caatattggc ttcatccacc     3240



acatacaggc cgtagcggtc gcacagcgtg taccacagcg gatggttcgg ataatgcgaa     3300



cagcgcacgg cgttaaagtt gttctgcttc atcagcagga tatcctgcac catcgtctgc     3360



tcatccatga cctgaccatg cagaggatga tgctcgtgac ggttaacgcc tcgaatcagc     3420



aacggcttgc cgttcagcag cagcagacca ttttcaatcc gcacctcgcg gaaaccgaca     3480



tcgcaggctt ctgcttcaat cagcgtgccg tcggcggtgt gcagttcaac caccgcacga     3540



tagagattcg ggatttcggc gctccacagt ttcgggtttt cgacgttcag acgtagtgtg     3600



acgcgatcgg cataaccacc acgctcatcg ataatttcac cgccgaaagg cgcggtgccg     3660



ctggcgacct gcgtttcacc ctgccataaa gaaactgtta cccgtaggta gtcacgcaac     3720



tcgccgcaca tctgaacttc agcctccagt acagcgcggc tgaaatcatc attaaagcga     3780



gtggcaacat ggaaatcgct gatttgtgta gtcggtttat gcagcaacga gacgtcacgg     3840



aaaatgccgc tcatccgcca catatcctga tcttccagat aactgccgtc actccaacgc     3900



agcaccatca ccgcgaggcg gttttctccg gcgcgtaaaa atgcgctcag gtcaaattca     3960



gacggcaaac gactgtcctg gccgtaaccg acccagcgcc cgttgcacca cagatgaaac     4020



gccgagttaa cgccatcaaa aataattcgc gtctggcctt cctgtagcca gctttcatca     4080



acattaaatg tgagcgagta acaacccgtc ggattctccg tgggaacaaa cggcggattg     4140



accgtaatgg gataggttac gttggtgtag atgggcgcat cgtaaccgtg catctgccag     4200



tttgagggga cgacgacagt atcggcctca ggaagatcgc actccagcca gctttccggc     4260



accgcttctg gtgccggaaa ccaggcaaag cgccattcgc cattcaggct gcgcaactgt     4320



tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt     4380



gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg     4440



acgggatcag ccattttttt ctccttactt acttaggatc cccgggtacc gagctcgaat     4500



tggggatctt gaagttccta ttccgaagtt cctattctct agaaagtata ggaacttcag     4560



agcgcttttg aagctaattc gagctcggta cccggggatc ccccgggctc gactgcatta     4620



atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgctcgaat     4680



tgacataagc ctgttcggtt cgtaaactgt aatgcaagta gcgtatgcgc tcacgcaact     4740



ggtccagaac cttgaccgaa cgcagcggtg gtaacggcgc agtggcggtt ttcatggctt     4800



gttatgactg tttttttgta ctcgagcaga aagtcaaaag cctccgaccg gaggcttttg     4860



acttgagggg gatcgatccc ttatggctct gcacccggct ccatcaccaa caggtcgcgc     4920



acgcgcttca ctcggttgcg gatcgacact gccagcccaa caaagccggt tgccgccgcc     4980



gccaggatcg cgccgatgat gccggccaca ccggccatcg cccaccaggt cgccgccttc     5040



cggttccatt cctgctggta ctgcttcgca atgctggacc tcggctcacc ataggctgac     5100



cgctcgatgg cgtatgccgc ttctcccctt ggcgtaaaac ccagcgccgc aggcggcatt     5160



gccatgctgc ccgccgcttt cccgaccacg acgcgcgcac caggcttgcg gtccagacct     5220



tcggccacgg cgagctgcgc aaggacataa tcagccgccg acttggctcc acgcgcctcg     5280



atcagctctt gcactcgcgc gaaatccttg gcctccacgg ccgccatgaa tcgcgcacgc     5340



ggcgaaggct ccgcagggcc ggcgtcgtga tcgccgccga gaatgccctt caccaagttc     5400



gacgacacga aaatcatgct gacggctatc accatcatgc agacggatcg cacgaacccg     5460



cagaactcac ccccgaacac gagcacggca cccgcgacca ctatgccaag aatgcccaag     5520



gtaaaaattg ccggccccgc catgaagtcc gtgaatgccc cgacggccga agtgaagggc     5580



aggccgccac ccaggccgcc gccctcactg cccggcacct ggtcgctgaa tgtcgatgcc     5640



agcacctgcg gcacgtcaat gcttccgggc gtcgcgctcg ggctgatcgc ccatcccgtt     5700



actgccccga tcccggcaat ggcaaggact gccagcgccg cgatgaggaa gcgggtgccc     5760



cgcttcttca tcttcgcgcc tcgggcctcc aggccgccta cctgggcgaa aacatcggtg     5820



tttgtggcat tcatacggac tcctgttggg ccagctcgcg cacgggctgg cgggtcagct     5880



tggcttgaag atcgccacgc attgcggcga tctgcttctc ggcatccttg cgcttctgca     5940



cgccttcctg ctggatgcga ataacgtcct cgacggtctt gatgagcgtc gtctgaacct     6000



gcttgagcgt gtccacgtcg atcaccaggc gttggttctc cttcgccgtc tcgacggacg     6060



tgcgatgcag cagggccgca ttgcgcttca tcaggtcgtt ggtggtgtcg tcgatggccg     6120



tggccagttc gacggcgttc ttctgctcgt tgaggctcaa ggccagcatg aattgccgct     6180



tccacgccgg cacggtgatt tcgcggatgg tgtggaattt atcgaccagc atctggttgt     6240



tggcctggat catgcggatg gtcggcaggc tctgcatggc cgaatgttgc aaggcgatca     6300



ggtcgccgat gcgcttgtcc aggttggcaa ccatcgcatc gaggtcggcc agctcctgca     6360



cgcggccagg gtcgttcccg acattgccgc gcagaccctc ggcctgctcg cgcagctcgg     6420



caaggcggac cttgccggcc gcgatgtgga cgccaagaag gcggtgttcc tcgcgcacgg     6480



ctgcgaacat ttcgtcgagc gaggcattgc gctgcgcgat gccttgctgg gtggtctgca     6540



cttcgctgac caggtgttcg atctgctcgc gggtcgtgtc gaagcgcgcc atgaagcccg     6600



tcgaacggac gcggaagcgg tcgatcagcg ggccaatcag gggcaggcgg gaacggttgt     6660



cggacaaagg gccgacgttc agggaacggg ccttggcgac aacctgggtc agtttctcgc     6720



ctgcttcgtc caggtcgctg ttgcgcacct ggtccagcag gctatcggcg tagcgggacg     6780



tgtgctcggc cacgtcgcgg ccgaactcgg caacggtctg cggactgccg acctcgatcc     6840



gctgcgcgac cgcatggact tccggcacgt cgctttcctg caagcccagc tcgcgcaggg     6900



ttgccggggt catgtcgaag gcgacgatag gggccttggc gtcgtgcgtc gttttcagtg     6960



cgttcatagg gttctcccgc cgtgttattg gttgatgcct tccaggctct gcgaaaggct     7020



ccgcatgagc gcctggtgag ctttggccgc ctcggcgacc attgccggat tcatgttctt     7080



ggtggtgatg agcgcgaggg tgtgctgacg ccagacgggc accaggacgg atgccgtttc     7140



agagaagcgg tccagcatgt ccacggcctg cgcccgcgtg agcttcatct gagtgacgct     7200



catttcatgg gacgccatga gggttgccag gttggcgagc ttgcgcgcga agcgttcgcg     7260



cggcttgtcg aactcgatca cgccggcctt ggccgcgccg gcctcggggt tctcgtccag     7320



gaactcgcgc ccggcttgaa tgtaggctct gagccggtct acctcggcct catgcgtatt     7380



gagcatgtca tccaaggcgc gcaacgtgtc ccgcacgcgc tgcgctacgc cctcggcttc     7440



gtccagcaac tggtcgagcg tcttgcgggc gacctgatac ctcacctggc gttcaacctc     7500



acggccaagc atcttctcga accaggtagg cttttccgcg atcttgcggg ggtccgcgtc     7560



ggccagcttc gccacgatct ggctgatttt gtcggccagc gcggcaactg cgccgtgctc     7620



catcagattc gacagctcgt tgagggaatc cgccccgtcg atgccggccc cgtactcgcc     7680



aatcgtcgcc ggcgacgcga agagggcggg caaaacctcc cccttcaatc gcgccatgtt     7740



cacgctttgt tcttccatgg tatatctcct tcttaaagtt aaacaaaatt attcggaacc     7800



cagcatgata ttccggaaat accaactaag tcaacggctg atggccaatt cggcttcctc     7860



gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa     7920



ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagatcg     7980



atcagcagtt caacctgttg atagtacgta ctaagctctc atgtttcacg tactaagctc     8040



tcatgtttaa cgtactaagc tctcatgttt aacgaactaa accctcatgg ctaacgtact     8100



aagctctcat ggctaacgta ctaagctctc atgtttcacg tactaagctc tcatgtttga     8160



acaataaaat taatataaat cagcaactta aatagcctct aaggttttaa gttttataag     8220



aaaaaaaaga atatataagg cttttaaagc tagcttttaa ggtttaacgg ttgtggacaa     8280



caagccaggg atgtaacgca ctgagaagcc cttagagcct ctcaaagcaa ttttcagtga     8340



cacaggaaca cttaacggct gacatgacgc tcagtggaac gaaaactc                  8388





<210>  433

<211>  483

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Streptavidin coding sequence



<400>  433

gacccgagca aagattctaa agcacaagta tctgctgcag aagcaggaat tacaggcaca       60



tggtataatc agctgggatc tacatttatt gttacagccg gcgcagatgg agctcttaca      120



ggaacatatg aatctgctgt tggaaatgca gaatctagat acgtgcttac aggaagatat      180



gattctgcac ctgcaacaga tggatccgga acagcacttg gatggacagt tgcatggaaa      240



aacaattata gaaacgcaca tagcgctaca acatggtctg gccaatatgt gggaggtgca      300



gaagcaagaa ttaacacaca atggctttta acatctggaa caacagaagc aaatgcatgg      360



aaaagtactc ttgttggaca tgatacattt acaaaagtta aacctagcgc agcatctatc      420



gatgcagcga aaaaagcagg agttaacaat ggcaatcctt tagatgcagt tcaacaataa      480



tga                                                                    483





<210>  434

<211>  216

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Pseudomonas exotoxin



<400>  434



Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly 

1               5                   10                  15      





Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu 

            20                  25                  30          





Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu 

        35                  40                  45              





Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp 

    50                  55                  60                  





Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu 

65                  70                  75                  80  





Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile 

                85                  90                  95      





Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro 

            100                 105                 110         





Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly 

        115                 120                 125             





Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala 

    130                 135                 140                 





Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly 

145                 150                 155                 160 





Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr 

                165                 170                 175     





Asp Pro Arg Asn Val Gly Gly Asp Leu Ala Pro Ser Ser Ile Pro Asp 

            180                 185                 190         





Gln Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly 

        195                 200                 205             





Lys Pro Ser Arg Glu Asp Leu Lys 

    210                 215     





<210>  435

<211>  536

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Diphtheria toxin



<400>  435



Met Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu 

1               5                   10                  15      





Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile 

            20                  25                  30          





Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp 

        35                  40                  45              





Asp Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala 

    50                  55                  60                  





Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly 

65                  70                  75                  80  





Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys 

                85                  90                  95      





Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr 

            100                 105                 110         





Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe 

        115                 120                 125             





Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly 

    130                 135                 140                 





Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu 

145                 150                 155                 160 





Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln 

                165                 170                 175     





Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val 

            180                 185                 190         





Arg Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp 

        195                 200                 205             





Val Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His 

    210                 215                 220                 





Gly Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser 

225                 230                 235                 240 





Glu Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu 

                245                 250                 255     





Glu His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro 

            260                 265                 270         





Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln 

        275                 280                 285             





Val Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala 

    290                 295                 300                 





Leu Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly 

305                 310                 315                 320 





Ala Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu 

                325                 330                 335     





Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val 

            340                 345                 350         





Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu 

        355                 360                 365             





Phe Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly 

    370                 375                 380                 





His Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn 

385                 390                 395                 400 





Thr Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly 

                405                 410                 415     





His Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly 

            420                 425                 430         





Val Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys 

        435                 440                 445             





Thr His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala 

    450                 455                 460                 





Ile Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val 

465                 470                 475                 480 





Gly Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser 

                485                 490                 495     





Ser Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val 

            500                 505                 510         





Leu Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu 

        515                 520                 525             





Ser Leu Phe Phe Glu Ile Lys Ser 

    530                 535     





<210>  436

<211>  127

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Interleukin 2



<400>  436



Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln 

1               5                   10                  15      





Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg 

            20                  25                  30          





Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys 

        35                  40                  45              





His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu 

    50                  55                  60                  





Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile 

65                  70                  75                  80  





Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr 

                85                  90                  95      





Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu 

            100                 105                 110         





Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 

        115                 120                 125         





<210>  437

<211>  207

<212>  PRT

<213>  Artificial sequence



<220>

<223>  CD3



<400>  437



Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 

1               5                   10                  15      





Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 

            20                  25                  30          





Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 

        35                  40                  45              





Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 

    50                  55                  60                  





Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 

65                  70                  75                  80  





His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 

                85                  90                  95      





Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 

            100                 105                 110         





Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 

        115                 120                 125             





Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 

    130                 135                 140                 





Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 

145                 150                 155                 160 





Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 

                165                 170                 175     





Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 

            180                 185                 190         





Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 

        195                 200                 205         





<210>  438

<211>  290

<212>  PRT

<213>  Artificial sequence



<220>

<223>  CD16



<400>  438



Met Gly Gly Gly Ala Gly Glu Arg Leu Phe Thr Ser Ser Cys Leu Val 

1               5                   10                  15      





Gly Leu Val Pro Leu Gly Leu Arg Ile Ser Leu Val Thr Cys Pro Leu 

            20                  25                  30          





Gln Cys Gly Ile Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu 

        35                  40                  45              





Leu Val Ser Ala Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val 

    50                  55                  60                  





Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr 

65                  70                  75                  80  





Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp 

                85                  90                  95      





Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile 

            100                 105                 110         





Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn 

        115                 120                 125             





Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp 

    130                 135                 140                 





Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile 

145                 150                 155                 160 





His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr 

                165                 170                 175     





Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp 

            180                 185                 190         





Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys 

        195                 200                 205             





Arg Gly Leu Phe Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile 

    210                 215                 220                 





Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro 

225                 230                 235                 240 





Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala 

                245                 250                 255     





Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser 

            260                 265                 270         





Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln 

        275                 280                 285             





Asp Lys 

    290 





<210>  439

<211>  153

<212>  PRT

<213>  Artificial sequence



<220>

<223>  interleukin 4



<400>  439



Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 

1               5                   10                  15      





Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 

            20                  25                  30          





Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 

        35                  40                  45              





Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 

    50                  55                  60                  





Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 

65                  70                  75                  80  





Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 

                85                  90                  95      





Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 

            100                 105                 110         





Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 

        115                 120                 125             





Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 

    130                 135                 140                 





Arg Glu Lys Tyr Ser Lys Cys Ser Ser 

145                 150             





<210>  440

<211>  365

<212>  PRT

<213>  Artificial sequence



<220>

<223>  HLA-A2



<400>  440



Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 

1               5                   10                  15      





Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 

            20                  25                  30          





Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 

        35                  40                  45              





Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 

    50                  55                  60                  





Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 

65                  70                  75                  80  





Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln 

                85                  90                  95      





Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 

            100                 105                 110         





Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly 

        115                 120                 125             





Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 

    130                 135                 140                 





Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 

145                 150                 155                 160 





Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 

                165                 170                 175     





Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 

            180                 185                 190         





Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 

        195                 200                 205             





Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 

    210                 215                 220                 





Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 

225                 230                 235                 240 





Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 

                245                 250                 255     





Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 

            260                 265                 270         





Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 

        275                 280                 285             





Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 

    290                 295                 300                 





Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala 

305                 310                 315                 320 





Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 

                325                 330                 335     





Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 

            340                 345                 350         





Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 

        355                 360                 365 





<210>  441

<211>  178

<212>  PRT

<213>  Artificial sequence



<220>

<223>  interleukin 10



<400>  441



Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 

1               5                   10                  15      





Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 

            20                  25                  30          





Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 

        35                  40                  45              





Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 

    50                  55                  60                  





Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 

65                  70                  75                  80  





Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 

                85                  90                  95      





Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 

            100                 105                 110         





Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 

        115                 120                 125             





Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 

    130                 135                 140                 





Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 

145                 150                 155                 160 





Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 

                165                 170                 175     





Arg Asn 

        





<210>  442

<211>  576

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Ricin toxin



<400>  442



Met Lys Pro Gly Gly Asn Thr Ile Val Ile Trp Met Tyr Ala Val Ala 

1               5                   10                  15      





Thr Trp Leu Cys Phe Gly Ser Thr Ser Gly Trp Ser Phe Thr Leu Glu 

            20                  25                  30          





Asp Asn Asn Ile Phe Pro Lys Gln Tyr Pro Ile Ile Asn Phe Thr Thr 

        35                  40                  45              





Ala Gly Ala Thr Val Gln Ser Tyr Thr Asn Phe Ile Arg Ala Val Arg 

    50                  55                  60                  





Gly Arg Leu Thr Thr Gly Ala Asp Val Arg His Glu Ile Pro Val Leu 

65                  70                  75                  80  





Pro Asn Arg Val Gly Leu Pro Ile Asn Gln Arg Phe Ile Leu Val Glu 

                85                  90                  95      





Leu Ser Asn His Ala Glu Leu Ser Val Thr Leu Ala Leu Asp Val Thr 

            100                 105                 110         





Asn Ala Tyr Val Val Gly Tyr Arg Ala Gly Asn Ser Ala Tyr Phe Phe 

        115                 120                 125             





His Pro Asp Asn Gln Glu Asp Ala Glu Ala Ile Thr His Leu Phe Thr 

    130                 135                 140                 





Asp Val Gln Asn Arg Tyr Thr Phe Ala Phe Gly Gly Asn Tyr Asp Arg 

145                 150                 155                 160 





Leu Glu Gln Leu Ala Gly Asn Leu Arg Glu Asn Ile Glu Leu Gly Asn 

                165                 170                 175     





Gly Pro Leu Glu Glu Ala Ile Ser Ala Leu Tyr Tyr Tyr Ser Thr Gly 

            180                 185                 190         





Gly Thr Gln Leu Pro Thr Leu Ala Arg Ser Phe Ile Ile Cys Ile Gln 

        195                 200                 205             





Met Ile Ser Glu Ala Ala Arg Phe Gln Tyr Ile Glu Gly Glu Met Arg 

    210                 215                 220                 





Thr Arg Ile Arg Tyr Asn Arg Arg Ser Ala Pro Asp Pro Ser Val Ile 

225                 230                 235                 240 





Thr Leu Glu Asn Ser Trp Gly Arg Leu Ser Thr Ala Ile Gln Glu Ser 

                245                 250                 255     





Asn Gln Gly Ala Phe Ala Ser Pro Ile Gln Leu Gln Arg Arg Asn Gly 

            260                 265                 270         





Ser Lys Phe Ser Val Tyr Asp Val Ser Ile Leu Ile Pro Ile Ile Ala 

        275                 280                 285             





Leu Met Val Tyr Arg Cys Ala Pro Pro Pro Ser Ser Gln Phe Ser Leu 

    290                 295                 300                 





Leu Ile Arg Pro Val Val Pro Asn Phe Asn Ala Asp Val Cys Met Asp 

305                 310                 315                 320 





Pro Glu Pro Ile Val Arg Ile Val Gly Arg Asn Gly Leu Cys Val Asp 

                325                 330                 335     





Val Arg Asp Gly Arg Phe His Asn Gly Asn Ala Ile Gln Leu Trp Pro 

            340                 345                 350         





Cys Lys Ser Asn Thr Asp Ala Asn Gln Leu Trp Thr Leu Lys Arg Asp 

        355                 360                 365             





Asn Thr Ile Arg Ser Asn Gly Lys Cys Leu Thr Thr Tyr Gly Tyr Ser 

    370                 375                 380                 





Pro Gly Val Tyr Val Met Ile Tyr Asp Cys Asn Thr Ala Ala Thr Asp 

385                 390                 395                 400 





Ala Thr Arg Trp Gln Ile Trp Asp Asn Gly Thr Ile Ile Asn Pro Arg 

                405                 410                 415     





Ser Ser Leu Val Leu Ala Ala Thr Ser Gly Asn Ser Gly Thr Thr Leu 

            420                 425                 430         





Thr Val Gln Thr Asn Ile Tyr Ala Val Ser Gln Gly Trp Leu Pro Thr 

        435                 440                 445             





Asn Asn Thr Gln Pro Phe Val Thr Thr Ile Val Gly Leu Tyr Gly Leu 

    450                 455                 460                 





Cys Leu Gln Ala Asn Ser Gly Gln Val Trp Ile Glu Asp Cys Ser Ser 

465                 470                 475                 480 





Glu Lys Ala Glu Gln Gln Trp Ala Leu Tyr Ala Asp Gly Ser Ile Arg 

                485                 490                 495     





Pro Gln Gln Asn Arg Asp Asn Cys Leu Thr Ser Asp Ser Asn Ile Arg 

            500                 505                 510         





Glu Thr Val Val Lys Ile Leu Ser Cys Gly Pro Ala Ser Ser Gly Gln 

        515                 520                 525             





Arg Trp Met Phe Lys Asn Asp Gly Thr Ile Leu Asn Leu Tyr Ser Gly 

    530                 535                 540                 





Leu Val Leu Asp Val Arg Ala Ser Asp Pro Ser Leu Lys Gln Ile Ile 

545                 550                 555                 560 





Leu Tyr Pro Leu His Gly Asp Pro Asn Gln Ile Trp Leu Pro Leu Phe 

                565                 570                 575     





<210>  443

<211>  651

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Pseudomonas exotoxin coding sequence



<400>  443

gcggagttcc tcggcgacgg cggcgacgtc agcttcagca cccgcggcac gcagaactgg       60



acggtggagc ggctgctcca ggcgcaccgc caactggagg agcgcggcta tgtgttcgtc      120



ggctaccacg gcaccttcct cgaagcggcg caaagcatcg tcttcggcgg ggtgcgcgcg      180



cgcagccagg accttgacgc gatctggcgc ggtttctata tcgccggcga tccggcgctg      240



gcctacggct acgcccagga ccaggaaccc gacgcgcgcg gccggatccg caacggtgcc      300



ctgctgcggg tctatgtgcc gcgctcgagt ctgccgggct tctaccgcac cggcctgacc      360



ctggccgcgc cggaggcggc gggcgaggtc gaacggctga tcggccatcc gctgccgctg      420



cgcctggacg ccatcaccgg ccccgaggag gaaggcgggc gcctggagac cattctcggc      480



tggccgctgg ccgagcgcac cgtggtgatt ccctcggcga tccccaccga cccacgcaac      540



gtcggcggcg acctcgcccc gtccagcatc cccgaccagg aacaggcgat cagcgccctg      600



ccggactacg ccagccagcc cggcaaaccg tcgcgcgagg acctgaagta a               651





<210>  444

<211>  1611

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Diphtheria toxin coding sequence



<400>  444

atgggcgctg atgatgttgt tgattcttct aaatcttttg tgatggaaaa cttttcttcg       60



taccacggga ctaaacctgg ttatgtagat tccattcaaa aaggtataca aaagccaaaa      120



tctggtacac aaggaaatta tgacgatgat tggaaagggt tttatagtac cgacaataaa      180



tacgacgctg cgggatactc tgtagataat gaaaacccgc tctctggaaa agctggaggc      240



gtggtcaaag tgacgtatcc aggactgacg aaggttctcg cactaaaagt ggataatgcc      300



gaaactatta agaaagagtt aggtttaagt ctcactgaac cgttgatgga gcaagtcgga      360



acggaagagt ttatcaaaag gttcggtgat ggtgcttcgc gtgtagtgct cagccttccc      420



ttcgctgagg ggagttctag cgttgaatat attaataact gggaacaggc gaaagcgtta      480



agcgtagaac ttgagattaa ttttgaaacc cgtggaaaac gtggccaaga tgcgatgtat      540



gagtatatgg ctcaagcctg tgcaggaaat cgtgtcaggc gatcagtagg tagctcattg      600



tcatgcataa atcttgattg ggatgtcata agggataaaa ctaagacaaa gatagagtct      660



ttgaaagagc atggccctat caaaaataaa atgagcgaaa gtcccaataa aacagtatct      720



gaggaaaaag ctaaacaata cctagaagaa tttcatcaaa cggcattaga gcatcctgaa      780



ttgtcagaac ttaaaaccgt tactgggacc aatcctgtat tcgctggggc taactatgcg      840



gcgtgggcag taaacgttgc gcaagttatc gatagcgaaa cagctgataa tttggaaaag      900



acaactgctg ctctttcgat acttcctggt atcggtagcg taatgggcat tgcagacggt      960



gccgttcacc acaatacaga agagatagtg gcacaatcaa tagctttatc atctttaatg     1020



gttgctcaag ctattccatt ggtaggagag ctagttgata ttggtttcgc tgcatataat     1080



tttgtagaga gtattatcaa tttatttcaa gtagttcata attcgtataa tcgtcccgcg     1140



tattctccgg ggcataaaac gcaaccattt cttcatgacg ggtatgctgt cagttggaac     1200



actgttgaag attcgataat ccgaactggt tttcaagggg agagtgggca cgacataaaa     1260



attactgctg aaaatacccc gcttccaatc gcgggtgtcc tactaccgac tattcctgga     1320



aagctggacg ttaataagtc caagactcat atttccgtaa atggtcggaa aataaggatg     1380



cgttgcagag ctatagacgg tgatgtaact ttttgtcgcc ctaaatctcc tgtttatgtt     1440



ggtaatggtg tgcatgcgaa tcttcacgtg gcatttcaca gaagcagctc ggagaaaatt     1500



cattctaatg aaatttcatc ggattccata ggcgttcttg ggtaccagaa aacagtagat     1560



cacaccaagg ttaattctaa gctatcgcta ttttttgaaa tcaaaagctg a              1611





<210>  445

<211>  698

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Interleukin 2 coding sequence





<220>

<221>  misc_feature

<222>  (4)..(4)

<223>  n is a, c, g, or t



<400>  445

gggnggggga caaagaaaac acagctacaa ctggagcatt tacttctgga tttacagatg       60



attttgaatg gaattaataa ttacaagaat cccaaactca ccaggatgct cacatttaag      120



ttttacatgc ccaagaaggc cacagaactg aaacatcttc agtgtctaga agaagaactc      180



aaacctctgg aggaagtgct aaatttagct caaagcaaaa actttcactt aagacccagg      240



gacttaatca gcaatatcaa cgtaatagtt ctggaactaa agggatctga aacaacattc      300



atgtgtgaat atgctgatga gacagcaacc attgtagaat ttctgaacag atggattacc      360



ttttgtcaaa gcatcatctc aacactgact tgataattaa gtgcttccca cttaaaacat      420



atcaggcctt ctatttattt aaatatttaa attttatatt tattgttgaa tgtatggttt      480



gctacctatt gtaactatta ttcttaatct taaaactata aatatggatc ttttatgatt      540



ctttttgtaa gccctagggg ctctaaaatg gtttcactta tttatcccaa aatatttatt      600



attatgttga atgttaaata tagtatctat gtagattggt tagtaaaact atttaataaa      660



tttgataaat ataaacaaaa aaaaaaaaac cccccccc                              698





<210>  446

<211>  1311

<212>  DNA

<213>  Artificial sequence



<220>

<223>  CD3 coding sequence



<400>  446

gtaagtctgc tggcctccgc catcttagta aagtaacagt cccatgaaac aaagatgcag       60



tcgggcactc actggagagt tctgggcctc tgcctcttat cagttggcgt ttgggggcaa      120



gatggtaatg aagaaatggg tggtattaca cagacaccat ataaagtctc catctctgga      180



accacagtaa tattgacatg ccctcagtat cctggatctg aaatactatg gcaacacaat      240



gataaaaaca taggcggtga tgaggatgat aaaaacatag gcagtgatga ggatcacctg      300



tcactgaagg aattttcaga attggagcaa agtggttatt atgtctgcta ccccagagga      360



agcaaaccag aagatgcgaa cttttatctc tacctgaggg caagagtgtg tgagaactgc      420



atggagatgg atgtgatgtc ggtggccaca attgtcatag tggacatctg catcactggg      480



ggcttgctgc tgctggttta ctactggagc aagaatagaa aggccaaggc caagcctgtg      540



acacgaggag cgggtgctgg cggcaggcaa aggggacaaa acaaggagag gccaccacct      600



gttcccaacc cagactatga gcccatccgg aaaggccagc gggacctgta ttctggcctg      660



aatcagagac gcatctgacc ctctggagaa cactgcctcc cgctggccca ggtctcctct      720



ccagtccccc tgcgactccc tgtttcctgg gctagtcttg gaccccacga gagagaatcg      780



ttcctcagcc tcatggtgaa ctcgcgccct ccagcctgat cccccgctcc ctcctccctg      840



ccttctctgc tggtacccag tcctaaaata ttgctgcttc ctcttccttt gaagcatcat      900



cagtagtcac accctcacag ctggcctgcc ctcttgccag gatatttatt tgtgctattc      960



actcccttcc ctttggatgt aacttctccg ttcagttccc tccttttctt gcatgtaagt     1020



tgtcccccat cccaaagtat tccatctact tttctatcgc cgtccccttt tgcagccctc     1080



tctggggatg gactgggtaa atgttgacag aggccctgcc ccgttcacag atcctggccc     1140



tgagccagcc ctgtgctcct ccctccccca acactcccta ccaaccccct aatcccctac     1200



tccctccaac cccccctccc actgtaggcc actggatggt catttggcat ctccgtatat     1260



gtgctctggc tcctcagctg agagagaaaa aaataaactg tatttggctg c              1311





<210>  447

<211>  2406

<212>  DNA

<213>  Artificial sequence



<220>

<223>  CD16 coding sequence



<400>  447

gattctgtgt gtgtcctcag atgctcagcc acagaccttt gagggagtaa agggggcaga       60



cccacccacc ttgcctccag gctctttcct tcctggtcct gttctatggt ggggctccct      120



tgccagactt cagactgaga agtcagatga agtttcaaga aaaggaaatt ggtgggtgac      180



agagatgggt ggaggggctg gggaaaggct gtttacttcc tcctgtctag tcggtttggt      240



ccctttaggg ctccggatat ctttggtgac ttgtccactc cagtgtggca tcatgtggca      300



gctgctcctc ccaactgctc tgctacttct agtttcagct ggcatgcgga ctgaagatct      360



cccaaaggct gtggtgttcc tggagcctca atggtacagg gtgctcgaga aggacagtgt      420



gactctgaag tgccagggag cctactcccc tgaggacaat tccacacagt ggtttcacaa      480



tgagagcctc atctcaagcc aggcctcgag ctacttcatt gacgctgcca cagtcgacga      540



cagtggagag tacaggtgcc agacaaacct ctccaccctc agtgacccgg tgcagctaga      600



agtccatatc ggctggctgt tgctccaggc ccctcggtgg gtgttcaagg aggaagaccc      660



tattcacctg aggtgtcaca gctggaagaa cactgctctg cataaggtca catatttaca      720



gaatggcaaa ggcaggaagt attttcatca taattctgac ttctacattc caaaagccac      780



actcaaagac agcggctcct acttctgcag ggggcttttt gggagtaaaa atgtgtcttc      840



agagactgtg aacatcacca tcactcaagg tttggcagtg tcaaccatct catcattctt      900



tccacctggg taccaagtct ctttctgctt ggtgatggta ctcctttttg cagtggacac      960



aggactatat ttctctgtga agacaaacat tcgaagctca acaagagact ggaaggacca     1020



taaatttaaa tggagaaagg accctcaaga caaatgaccc ccatcccatg ggggtaataa     1080



gagcagtagc agcagcatct ctgaacattt ctctggattt gcaaccccat catcctcagg     1140



cctctctaca agcagcagga aacatagaac tcagagccag atcccttatc caactctcga     1200



cttttccttg gtctccagtg gaagggaaaa gcccatgatc ttcaagcagg gaagccccag     1260



tgagtagctg cattcctaga aattgaagtt tcagagctac acaaacactt tttctgtccc     1320



aaccgttccc tcacagcaaa gcaacaatac aggctaggga tggtaatcct ttaaacatac     1380



aaaaattgct cgtgttataa attacccagt ttagagggga aaaaaaaaca attattccta     1440



aataaatgga taagtagaat taatggttga ggcaggacca tacagagtgt gggaactgct     1500



ggggatctag ggaattcagt gggaccaatg aaagcatggc tgagaaatag caggtagtcc     1560



aggatagtct aagggaggtg ttcccatctg agcccagaga taagggtgtc ttcctagaac     1620



attagccgta gtggaattaa caggaaatca tgagggtgac gtagaattga gtcttccagg     1680



ggactctatc agaactggac catctccaag tatataacga tgagtcctct taatgctagg     1740



agtagaaaat ggtcctagga aggggactga ggattgcggt ggggggtggg gtggaaaaga     1800



aagtacagaa caaaccctgt gtcactgtcc caagttgcta agtgaacaga actatctcag     1860



catcagaatg agaaagcctg agaagaaaga accaaccaca agcacacagg aaggaaagcg     1920



caggaggtga aaatgctttc ttggccaggg tagtaagaat tagaggttaa tgcagggact     1980



gtaaaaccac cttttctgct tcaatatcta attcctgtgt agctttgttc attgcattta     2040



ttaaacaaat gttgtataac caatactaaa tgtactactg agcttcgctg agttaagtta     2100



tgaaactttc aaatccttca tcatgtcagt tccaatgagg tggggatgga gaagacaatt     2160



gttgcttatg aaagaaagct ttagctgtct ctgttttgta agctttaagc gcaacatttc     2220



ttggttccaa taaagcattt tacaagatct tgcatgctac tcttagatag aagatgggaa     2280



aaccatggta ataaaatatg aatgataaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2340



aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2400



aaaaaa                                                                2406





<210>  448

<211>  921

<212>  DNA

<213>  Artificial sequence



<220>

<223>  interleukin 4 coding sequence



<400>  448

ttctatgcaa agcaaaaagc cagcagcagc cccaagctga taagattaat ctaaagagca       60



aattatggtg taatttccta tgctgaaact ttgtagttaa ttttttaaaa aggtttcatt      120



ttcctattgg tctgatttca caggaacatt ttacctgttt gtgaggcatt ttttctcctg      180



gaagagaggt gctgattggc cccaagtgac tgacaatctg gtgtaacgaa aatttccaat      240



gtaaactcat tttccctcgg tttcagcaat tttaaatcta tatatagaga tatctttgtc      300



agcattgcat cgttagcttc tcctgataaa ctaattgcct cacattgtca ctgcaaatcg      360



acacctatta atgggtctca cctcccaact gcttccccct ctgttcttcc tgctagcatg      420



tgccggcaac tttgtccacg gacacaagtg cgatatcacc ttacaggaga tcatcaaaac      480



tttgaacagc ctcacagagc agaagactct gtgcaccgag ttgaccgtaa cagacatctt      540



tgctgcctcc aagaacacaa ctgagaagga aaccttctgc agggctgcga ctgtgctccg      600



gcagttctac agccaccatg agaaggacac tcgctgcctg ggtgcgactg cacagcagtt      660



ccacaggcac aagcagctga tccgattcct gaaacggctc gacaggaacc tctggggcct      720



ggcgggcttg aattcctgtc ctgtgaagga agccaaccag agtacgttgg aaaacttctt      780



ggaaaggcta aagacgatca tgagagagaa atattcaaag tgttcgagct gaatatttta      840



atttatgagt ttttgatagc tttatttttt aagtatttat atatttataa ctcatcataa      900



aataaagtat atatagaatc t                                                921





<210>  449

<211>  4000

<212>  DNA

<213>  Artificial sequence



<220>

<223>  HLA-A2  coding sequence



<400>  449

aagcttactc tctggcacca aactccatgg gatgattttt ccttcctaga agagtccagg       60



tggacaggta aggagtggga gtcagggagt ccagttccag ggacagagat tacgggataa      120



aaagtgaaag gagagggacg gggcccatgc cgagggtttc tcccttgttt ctcagacagc      180



tcttgggcca agactcaggg agacattgag acagagcgct tggcacagaa gcagaggggt      240



cagggcgaag tccagggccc caggcgttgg ctctcagggt ctcaggcccc gaaggcggtg      300



tatggattgg ggagtcccag ccttggggat tccccaactc cgcagtttct tttctccctc      360



tcccaaccta tgtagggtcc ttcttcctgg atactcacga cgcggaccca gttctcactc      420



ccattgggtg tcgggtttcc agagaagcca atcagtgtcg tcgcggtcgc ggttctaaag      480



tccgcacgca cccaccggga ctcagattct ccccagacgc cgaggatggc cgtcatggcg      540



ccccgaaccc tcgtcctgct actctcgggg gctctggccc tgacccagac ctgggcgggt      600



gagtgcgggg tcgggaggga aacggcctct gtggggagaa gcaacgggcc gcctggcggg      660



ggcgcaggac ccgggaagcc gcgccgggag gagggtcggg cgggtctcag ccactcctcg      720



tccccaggct ctcactccat gaggtatttc ttcacatccg tgtcccggcc cggccgcggg      780



gagccccgct tcatcgcagt gggctacgtg gacgacacgc agttcgtgcg gttcgacagc      840



gacgccgcga gccagaggat ggagccgcgg gcgccgtgga tagagcagga gggtccggag      900



tattgggacg gggagacacg gaaagtgaag gcccactcac agactcaccg agtggacctg      960



gggaccctgc gcggctacta caaccagagc gaggccggtg agtgaccccg gcccggggcg     1020



caggtcacga cctctcatcc cccacggacg ggccaggtcg cccacagtct ccgggtccga     1080



gatccgcccc gaagccgcgg gaccccgaga cccttgcccc gggagaggcc caggcgcctt     1140



tacccggttt cattttcagt ttaggccaaa aatcccccca ggttggtcgg ggcggggcgg     1200



ggctcggggg accgggctga ccgcggggtc cgggccaggt tctcacaccg tccagaggat     1260



gtatggctgc gacgtggggt cggactggcg cttcctccgc gggtaccacc agtacgccta     1320



cgacggcaag gattacatcg ccctgaaaga ggacctgcgc tcttggaccg cggcggacat     1380



ggcagctcag accaccaagc acaagtggga ggcggcccat gtggcggagc agttgagagc     1440



ctacctggag ggcacgtgcg tggagtggct ccgcagatac ctggagaacg ggaaggagac     1500



gctgcagcgc acgggtacca ggggccacgg ggcgcctccc tgatcgcctg tagatctccc     1560



gggctggcct cccacaagga ggggagacaa ttgggaccaa cactagaata tcgccctccc     1620



tctggtcctg agggagagga atcctcctgg gtttccagat cctgtaccag agagtgactc     1680



tgaggttccg ccctgctctc tgacacaatt aagggataaa atctctgaag gaatgacggg     1740



aagacgatcc ctcgaatact gatgagtggt tccctttgac acacacaggc agcagccttg     1800



ggcccgtgac ttttcctctc aggccttgtt ctctgcttca cactcaatgt gtgtgggggt     1860



ctgagtccag cacttctgag tccttcagcc tccactcagg tcaggaccag aagtcgctgt     1920



tccctcttca gggactagaa tttccacgga ataggagatt atcccaggtg cctgtgtcca     1980



ggctggtgtc tgggttctgt gctcccttcc ccatcccagg tgtcctgtcc attctcaaga     2040



tagccacatg tgtgctggag gagtgtccca tgacagatcg aaaatgcctg aatgatctga     2100



ctcttcctga cagacgcccc caaaacgcat atgactcacc acgctgtctc tgaccatgaa     2160



gccaccctga ggtgctgggc cctgagcttc taccctgcgg agatcacact gacctggcag     2220



cgggatgggg aggaccagac ccaggacacg gagctcgtgg agaccaggcc tgcaggggat     2280



ggaaccttcc agaagtgggc ggctgtggtg gtgccttctg gacaggagca gagatacacc     2340



tgccatgtgc agcatgaggg tttgcccaag cccctcaccc tgagatgggg taaggaggga     2400



gacgggggtg tcatgtcttt tagggaaagc aggagcctct ctgaccttta gcagggtcag     2460



ggcccctcac cttcccctct tttcccagag ccgtcttccc agcccaccat ccccatcgtg     2520



ggcatcattg ctggcctggt tctctttgga gctgtgatca ctggagctgt ggtcgctgct     2580



gtgatgtgga ggaggaagag ctcaggtggg gaaggggtga agggtgggtc tgagatttct     2640



tgtctcactg agggttccaa gacccaggta gaagtgtgcc ctgcctcgtt actgggaagc     2700



accacccaca attatgggcc tacccagcct gggccctgtg tgccagcact tactcttttg     2760



taaagcacct gttaaaatga aggacagatt tatcaccttg attacagcgg tgatgggacc     2820



tgatcccagc agtcacaagt cacaggggaa ggtccctgag gaccttcagg agggcggttg     2880



gtccaggacc cacacctgct ttcttcatgt ttcctgatcc cgccctgggt ctgcagtcac     2940



acatttctgg aaacttctct gaggtccaag acttggaggt tcctctagga ccttaaggcc     3000



ctgactcttt tctggtatct cacaggacat tttcttccca cagatagaaa aggagggagc     3060



tactctcagg ctgcaagtaa gtatgaagga ggctgatgcc tgaggtcctt gggatattgt     3120



gtttgggagc ccatggggga gctcacccac cccacaattc ctcctctagc cacatcttct     3180



gtgggatctg accaggttct gtttttgttc taccccaggc agtgacagtg cccagggctc     3240



tgatgtgtct ctcacagctt gtaaaggtga gagcctggag ggcctgatgt gtgttgggtg     3300



ttgggcggaa cagtggacac agctgtgcta tggggtttct ttccattgga tgtattgagc     3360



atgcgatggg ctgtttaaag tgtgacccct cactgtgaca gatacgaatt tgttcatgaa     3420



tatttttttc tatagtgtga gacagctgcc ttgtgtggga ctgagaggca agagttgttc     3480



ctgcccttcc ctttgtgact tgaagaaccc tgactttgtt tctgcaaagg cacctgcatg     3540



tgtctgtgtt cgtgtaggca taatgtgagg aggtggggag accaccccac ccccatgtcc     3600



accatgaccc tcttcccacg ctgacctgtg ctccctcccc aatcatcttt cctgttccag     3660



agaggtgggg ctgaggtgtc tccatctctg tctcaacttc atggtgcact gagctgtaac     3720



ttcttccttc cctattaaaa ttagaacctg agtataaatt tactttctca aattcttgcc     3780



atgagaggtt gatgagttaa ttaaaggaga agattcctaa aatttgagag acaaaataaa     3840



tggaacacat gagaaccttc cagagtccac gtgttgctta tgctgatttg ttgcagggga     3900



ggagagtaga tggggctgtg cccagtttct gttccggcca ctatgggctt tatgtggtca     3960



ctgcttggct gggtcatctt tgctgctcca ttgtccttgg                           4000





<210>  450

<211>  1601

<212>  DNA

<213>  Artificial sequence



<220>

<223>  interleukin 10 coding sequence



<400>  450

aaaccacaag acagacttgc aaaagaaggc atgcacagct cagcactgct ctgttgcctg       60



gtcctcctga ctggggtgag ggccagccca ggccagggca cccagtctga gaacagctgc      120



acccacttcc caggcaacct gcctaacatg cttcgagatc tccgagatgc cttcagcaga      180



gtgaagactt tctttcaaat gaaggatcag ctggacaact tgttgttaaa ggagtccttg      240



ctggaggact ttaagggtta cctgggttgc caagccttgt ctgagatgat ccagttttac      300



ctggaggagg tgatgcccca agctgagaac caagacccag acatcaaggc gcatgtgaac      360



tccctggggg agaacctgaa gaccctcagg ctgaggctac ggcgctgtca tcgatttctt      420



ccctgtgaaa acaagagcaa ggccgtggag caggtgaaga atgcctttaa taagctccaa      480



gagaaaggca tctacaaagc catgagtgag tttgacatct tcatcaacta catagaagcc      540



tacatgacaa tgaagatacg aaactgagac atcagggtgg cgactctata gactctagga      600



cataaattag aggtctccaa aatcggatct ggggctctgg gatagctgac ccagcccctt      660



gagaaacctt attgtacctc tcttatagaa tatttattac ctctgatacc tcaaccccca      720



tttctattta tttactgagc ttctctgtga acgatttaga aagaagccca atattataat      780



ttttttcaat atttattatt ttcacctgtt tttaagctgt ttccataggg tgacacacta      840



tggtatttga gtgttttaag ataaattata agttacataa gggaggaaaa aaaatgttct      900



ttggggagcc aacagaagct tccattccaa gcctgaccac gctttctagc tgttgagctg      960



ttttccctga cctccctcta atttatcttg tctctgggct tggggcttcc taactgctac     1020



aaatactctt aggaagagaa accagggagc ccctttgatg attaattcac cttccagtgt     1080



ctcggaggga ttcccctaac ctcattcccc aaccacttca ttcttgaaag ctgtggccag     1140



cttgttattt ataacaacct aaatttggtt ctaggccggg cgcggtggct cacgcctgta     1200



atcccagcac tttgggaggc tgaggcgggt ggatcacttg aggtcaggag ttcctaacca     1260



gcctggtcaa catggtgaaa ccccgtctct actaaaaata caaaaattag ccgggcatgg     1320



tggcgcgcac ctgtaatccc agctacttgg gaggctgagg caagagaatt gcttgaaccc     1380



aggagatgga agttgcagtg agctgatatc atgcccctgt actccagcct gggtgacaga     1440



gcaagactct gtctcaaaaa aataaaaata aaaataaatt tggttctaat agaactcagt     1500



tttaactaga atttattcaa ttcctctggg aatgttacat tgtttgtctg tcttcatagc     1560



agattttaat tttgaataaa taaatgtatc ttattcacat c                         1601





<210>  451

<211>  12150

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Ricin toxin coding sequence



<400>  451

atatttcacg aactgataca atatagcaag agattgaaaa aactcaaatt cttacaaaac       60



tgaactgaaa taaaacaaga gatgcataat aaaaaaatac aaatcttgat acttattaca      120



actggaatat gcgactaagc tgaaataaac tgacattaaa gacatgacag aaatacatgt      180



tttggtctat aacaacctaa gtagaaatcg cagcctgttg atgcacagat acatgtattc      240



ttatatattt gtattaatat tttaatttat gtacatatcg agatgaatga aaataagcta      300



atatttgtca tttagaaatt attccaaaac tgaatcatct tacttgagtt atttaattaa      360



taaaattaaa tatatttcat taaacaatgc attttctctt taaaacaatc catttgaatc      420



ttactttata ggaagacctt gatagataaa caatgtattg gatatacgtt ttttttagat      480



gctctaaaga ttgcattaga atgaaataaa actttttact tttaagattt ttgctcttta      540



aaataaaaag tacaaacttt gataagtttt atataaccta aaaagaaatt gtaacatgtg      600



agtttgagat gtcttatata atctacaaag atatttaaag agtataaaca gtaaagcaat      660



aatacttagg tgatgaaaat acctcactta gtactaatac aacaaagcaa gatatcgaac      720



aaatcttaaa tctttgcaaa actgaactga agtaaaacaa gaaatgcata ataataagac      780



aaatcttgga acttattata gctggaatat gccagtaagc tgaaataaat tgatactaag      840



gacacaacag aaacacatgc gtctgcaacc taagaagaag ttgcaacctg tcgatgcata      900



aatatacata tgcgacgtat attgctatgt atgaaaataa gcgaatactt atcatttgga      960



atttattcca aaattggatc atcttgctga gttattcaat taataataat gaatatattt     1020



tattaagaaa taaaaaattt accttttcct ctttaaaacg atttatttga atattacttt     1080



atgagaagac tttttataat cagaaaactt gatatataaa gaatgtattt gataatgttt     1140



ctttagagat gctctaaaga ttgtattgca cttaaataaa accttttact cttaatagtt     1200



tagtatttct caaaattatt actctttaaa gtaaatagct caaactttga gaagtcttat     1260



gtaaactaaa caaaaattgt aacctacgag tttgagatgt cttatacaac ctaaaataaa     1320



atttaaagaa tataaacttt aagatgtctt tttctatata atcaatttta ttttgaaaaa     1380



ccaccaaagc aaaaaaaatt taggtgatgg aaatatccta cctagaacta ataaaatata     1440



gcaaaagatt aaacaaatct caaattctta taaaattgaa ctgaagtaaa acaagagatg     1500



tataataaca aattttggta cttaatacaa aaatatgtca ttaagctaaa gtaaagtgat     1560



aataaggaca caatataaac acatgctttg gcctccagca atctaataag aaattgcaac     1620



ctatcgatgc acaaatacac gtatctttat atgcttatat aagtatttta atttgtgtac     1680



gtgtattcaa atgactgaaa ataaactaaa acttgtcata taaaattttt tcaaaattaa     1740



atgatcttgc taagttattc actaataata ataaatatat ttcattaaaa ataaaaattt     1800



gtcctttctc tataaaagag tccattagaa tcttactata tatgaaggct ttttataatt     1860



aaaaaacttg atatataaag aatgtattgg aggtgcattt tttttttgag atgttctgaa     1920



gattgcattg gactacaata aaagttttta cttttacttc ttagaattct tgctctttaa     1980



aataataagc acaaactttg agatgtcttg tagaacctaa gaaaaaaatt acaatttgtg     2040



atttttagat gttttataca atctaaaaag agatttgaag agtataaatt ttaagatgtt     2100



ttatacaacc taaaacaaat tgtaatctgt cgacgcacag acacgtattt ttatatattt     2160



ataaagatca ttttaattta tgtacttata tttagataaa taaaaataag ctaatatttg     2220



tcatatataa attatttcat aactgaattg tctgatttgt tagtgttatt aaattaataa     2280



taatagttat attttattaa ataataaaag atttaccttt tctctataaa aaggggaaga     2340



aatgtggtta ctaaaaccat ctcatattcc tccgctttct tcctcagctg ctcactttgt     2400



aagtattacg actttctcaa acttcctact tgttttcaat taatgttatt ctacctgact     2460



tcatatatat ctcttttctt ttgggatcat tattactgct actgtaatga tcgagaaaaa     2520



tctcttcttc ttatcattat gacttcatat attatcatct tctatcactt catataatgt     2580



ttttgatttt atgattcaat atatttataa ttaagttcta tctttaaacg agagcaacca     2640



attaaagaaa caagagtaaa tatatataaa ttgtaaggta ttatttgttt gatttaaatc     2700



attaaatagc tagatcttct ttttcttttc tttttttctt tctcatccaa agtttttatg     2760



aattgcaggc tattagtaat atagatggta gaaagaaaat taaaattaaa acttcttcaa     2820



tcatcacaaa tgagagtacc aactaaacta tgtgattttg gtaaaaaatg caaaacaagt     2880



acttatatat atatatatat atatatatat atatatatat atatatatat tcttttataa     2940



atcagtatat acattttact ctgattacca taatattata gattttacta aggtgacact     3000



aatgttatat attttggtta gaatggtagt gttttctttt cttaaagatg ctctagagga     3060



ttcttaacaa aagaatataa tatataaata atatattaaa gatgccctag aaaatgcatt     3120



tactgtactt aaataacctg ttttgctctt aatattttat tatttttatt tctataataa     3180



aaaatatttt aagaaatatt taagtataaa aaataaagta ttttattgat gtccactgta     3240



ctttttatat tttatttctt attttacttt tgtttccaag ggcatcaata tcttcttctt     3300



ttttctgttt aatttttatt aataaaaaaa ataattacaa atattaatta atcaaataca     3360



tagaaattta tttttataaa aaaaatcctt caaattcttt taaaatgtca ttttgaccct     3420



aaatttcttt taatagttag tgttctaata aaaaaaattt acccaataat ttttctaata     3480



tttcattatt cttttataag acaaactctt agcctctaga attattttaa ggatatatat     3540



aatttgtctc tctttctctt taacatagcc ttagtttcca ataaataaat aatgaaatat     3600



atttcactct tcatttcttt aaacttctta catttttttt tgtagcattc tttgtaagtg     3660



gaatgacaaa accgttaatg atgttctttt aaaagtgaaa gatgtttata tattgcagta     3720



cagataatga tatatctact gcactacata aaacaattta aatctccctg tttattttaa     3780



gaagttatat tttctttctt tctcatccta agaaagttaa attactgtaa tcgacattat     3840



atgaatttta actaattccg tttctaattt ataattattt cgttaaacca atcaattccc     3900



tttaaacact gcttatgcat attctgtctc aatttatata tggcatgcat cttccgtatt     3960



aatttataag ttcattttta ttgatcaagt atttgtggtt ttctttatat aaaaaaatgt     4020



attagtgttt ttctgtatta attttataag ttcatcttta tgagaatgct aatgtatttg     4080



gacagccaat aaaattccaa gaattgctgc aatcaaagat gaaaccggga ggaaatacta     4140



ttgtaatatg gatgtatgca gtggcaacat ggctttgttt tggatccacc tcagggtggt     4200



ctttcacatt agaggataac aacatattcc ccaaacaata cccaattata aactttacca     4260



cagcgggtgc cactgtgcaa agctacacaa actttatcag agctgttcgc ggtcgtttaa     4320



caactggagc tgatgtgaga catgaaatac cagtgttgcc aaacagagtt ggtttgccta     4380



taaaccaacg gtttatttta gttgaactct caaatcatgc agagctttct gttacattag     4440



cgctggatgt caccaatgca tatgtggtcg gctaccgtgc tggaaatagc gcatatttct     4500



ttcatcctga caatcaggaa gatgcagaag caatcactca tcttttcact gatgttcaaa     4560



atcgatatac attcgccttt ggtggtaatt atgatagact tgaacaactt gctggtaatc     4620



tgagagaaaa tatcgagttg ggaaatggtc cactagagga ggctatctca gcgctttatt     4680



attacagtac tggtggcact cagcttccaa ctctggctcg ttcctttata atttgcatcc     4740



aaatgatttc agaagcagca agattccaat atattgaggg agaaatgcgc acgagaatta     4800



ggtacaaccg gagatctgca ccagatccta gcgtaattac acttgagaat agttggggga     4860



gactttccac tgcaattcaa gagtctaacc aaggagcctt tgctagtcca attcaactgc     4920



aaagacgtaa tggttccaaa ttcagtgtgt acgatgtgag tatattaatc cctatcatag     4980



ctctcatggt gtatagatgc gcacctccac catcgtcaca gttttctttg cttataaggc     5040



cagtggtacc aaattttaat gctgatgttt gtatggatcc tgagcccata gtgcgtatcg     5100



taggtcgaaa tggtctatgt gttgatgtta gggatggaag attccacaac ggaaacgcaa     5160



tacagttgtg gccatgcaag tctaatacag atgcaaatca gctctggact ttgaaaagag     5220



acaatactat tcgatctaat ggaaagtgtt taactactta cgggtacagt ccgggagtct     5280



atgtgatgat ctatgattgc aatactgctg caactgatgc cacccgctgg caaatatggg     5340



ataatggaac catcataaat cccagatcta gtctagtttt agcagcgaca tcagggaaca     5400



gtggtaccac acttacagtg caaaccaaca tttatgccgt tagtcaaggt tggcttccta     5460



ctaataatac acaacctttt gtgacaacca ttgttgggct atatggtctg tgcttgcaag     5520



caaatagtgg acaagtatgg atagaggact gtagcagtga aaaggctgaa caacagtggg     5580



ctctttatgc agatggttca atacgtcctc agcaaaaccg agataattgc cttacaagtg     5640



attctaatat acgggaaaca gttgtcaaga tcctctcttg tggccctgca tcctctggcc     5700



aacgatggat gttcaagaat gatggaacca ttttaaattt gtatagtggg ttggtgttag     5760



atgtgagggc atcggatccg agccttaaac aaatcattct ttaccctctc catggtgacc     5820



caaaccaaat atggttacca ttattttgat agacagatta ctctcttgca gtgtgtatgt     5880



cctgccatga aaatagatgg cttaaataaa aaggacattg taaattttgt aactgaaagg     5940



acagcaagtt attgcagtcc agtatctaat aagagcacaa ctattgtctt gtgcattcta     6000



aatttatgga tgaattgtat gaattaagct aattattttg gtcatcagac ttgatatctt     6060



tttgaataaa ataaataata tgttttttca aacttataaa actatgaatg atatgaatat     6120



aatgcggaga ctagtcaatc ttttatgtaa ttctatgatg ataaaagctt gtctcttaac     6180



ttagtgaatt tgtatccaag taaaaaacag cctactaagt catggattcc ttcaaattta     6240



cgctcttatt ataagcttaa ttttcatcca cgatcatccc tattcatgtg atgcacaaga     6300



acttaaggta tatagatttg aagtaattcc ttaattataa tttttaagtt tatcactttc     6360



tttactttct aatttctttt tctcaaattg tactaattaa ctcattgaag aatttaacaa     6420



cttgttcatc agttccatag taattctcaa taaatttatg gtctcacaac tcaagcatcc     6480



atgggttcat aagttgtgat aatcaggcag cttcatatat attgaaatta acataaggag     6540



taaagtgggt tgagcaatgc caggtggtac atccaggtgg tacatccata tatacttctt     6600



cctccaaatc accatgtaaa aaagtatttt ttacatcaaa ttgtcttaat gcccatcctt     6660



tagttgctgc aatagaaatc agtattcaaa tcgtaccaag tttcgccaca ggtgcaaacg     6720



tttcctggta gtcaattcca tacttctgag taaatccttt cgctaccagt ctcgcttttc     6780



gcctgtctag actcccatct gccttaagct tcactgtata gatccattta cagccaatcg     6840



tattcttccc ctctggtaat ttcacaaact cccatgttgc attcttctct agggctttca     6900



cctcttcctc catcgcctct tttcatttca agtcttgcat tgcctcctgc acactattag     6960



gaatcgcaat cccggataat tcactagtgc taagtgcata ataatctgtt aaatgattat     7020



gtcgaatacc attcttagtt aaaaaattac ttaaatgact atccataaat tcctttgcat     7080



tatcagtttg ccaaactaaa acccatgtac gatattgatt tctaataaaa tttcaaaaat     7140



cacaaaaagc tttacttacc tcacttttgt tccgaagtaa ggttatccaa gtcatacgag     7200



tacattcgtc tataaaagtt ccgaaatatc tagcacctga taatgaagga atttttgcag     7260



gaccccaaac atcagaatgt ataacagcaa atggttcagt acttttatta aaactaggca     7320



aataagtagc acggtggctc ttaccaagtt cacacacatc acaattaaac acggaatcat     7380



ccaaattaac aaacaattca ggttttaatt ttttcaaata actaaatgac aaatgtccaa     7440



ggcgtcgatg ccatagccaa attctttcca ttgtattact taagctttca gtcgtgtaaa     7500



cctcacttat tttcttctct cctatctcag tcaagtctag ataataaagt ttgcctcgtt     7560



taacaccata accaagagtc tcccgagtca ggatgtcctg aaaaacacaa tatgaaggcc     7620



agaaagttac agtacagtta agagacgagg ttatttgtcc aaccgagagt aagttacaag     7680



acagtgtaag aacaatcaat acagatttta aattcagatt ttttgaaaga gtaatggatc     7740



cttctccact aacaatacat ttggatccat ttgttattga cacggtaaaa tgagaggatg     7800



gaatgaaaga ataaattcga tcagaattgc ataccatatg atcagatgca ccagggtcta     7860



ttgtccacaa tgttcacaca gcaagttaca tttttttcca gctccatttt tcctgttttt     7920



tccataattc tggcaaacct gaaatacagt aggctccaca gttgcatttg ttcctcccat     7980



tgtcttacat tgttgatctt ctcttcgaac ataagcatat gtttgttcta aatcaagttt     8040



agggtctttg cgcaaaatct cacctcggac ttgatcaaag tttgaatcaa gcccactgag     8100



gaagatatgc atgcgtagcc ttgccatggc agaatgcaac gctactactc catccactgt     8160



accttcatgt gactgagtac gatgatctat ctcttgaaag atttccatca actcagagta     8220



atacgtaggc aatggtctgc cctcttgttt gattgcgaaa gacttctgat tcaattcgaa     8280



taacctcgtt tcatcagttc catcataaaa tgtttttgct gctgcctccc aaacatcttt     8340



ggcagtagga agtctgatga aatgttgcat cagtgaaggt atcatcgaat caatcagcca     8400



gctctttacc ttttgattct cagttatcca ggtagagtat ctcgtatctg tagttgcagg     8460



cttcacttcc gatccggtta aatacccagt tttatttcgt gctccaatac gcatctccat     8520



gagctgtgac catagagaat aattcgattc atccagtata acactggtag ggaatgatac     8580



attatcttgt tgaatgataa tttgattcga agacggattc atgatttgag tatgaggtgg     8640



atcttctgta ctcataattc tgtttaggga ttcagttttg atttgaaaaa aatttgtttt     8700



cagtatggtg agcggctgtt gtgataccat gtgagtaatg aaactctaat aattgattaa     8760



ttttcatcct ttttctctat tcattcaacc tgaatatata caaaagtttg ttacaaggat     8820



aacttctaac tacttatgta acaagcaacc ttatcaaaaa tacaattaga ataacatcta     8880



actactacag cttatacata cttatctcta tactaacaaa ttaactaaat atagttaaca     8940



agttctgaat catagtaatt ttagtctcta taatattaac aaatgaggga ctaaaatact     9000



tttcttttct taaatatgat tctattttaa aaagcgggag atagaaaaat ttatataatt     9060



tcttactaaa aaaaagtaag gataatttta tttaattcta agaaacaaag caaaggaaaa     9120



tgggaaagtt tataatttga tctaatttct ttgcatgata gacaggtaac tgattctcaa     9180



tacgattcta agatgatcca atataaatta tttgtgggaa ataggttcac gaaaaagcca     9240



tttgttgggg attcaatgtt tattgatttg ttttgtgtag tatgttttgc atcaattaat     9300



tagatcagct agtcatttac atattcttgc aaatttgtgc catttacaaa tgaattatct     9360



gaatttagtg taatttgatt aatttaatta gacgggtttt ccttcttcag taatcaacat     9420



acacaaagtg aaaggcaaac gagttctagc aatttaattg attaggttca agttaattaa     9480



ttaatttgat aatttatggt tcagtccgtt actgaaaatt taaaaagaag tagcatgcat     9540



ctttagattc tttctctatt ttatgcatgc cattttctga ttaattgtat atgttcgttc     9600



ttcttgatta agtatttata tttatttttt atttgattag tgagctatat atatttttaa     9660



gagaatcttg atgtatttgg acaactaaaa aaattccaag aattgctaca attggagatg     9720



aaactgaaag gaaacactat ggtgtggata tacgcagtgg caacgtggct ctgcttggga     9780



tcagccttgg ggtggtaatt caatgccact gtaagctaca cattcccaac tgtaagcttt     9840



accactgttg atgccacgga gcaaatgtac agagagtgtt gtagaaaata agaataagta     9900



tatatactta tcggcttagt agccaagaag tcttttggta acctacaact cttaaacatc     9960



atatacttaa tacataagtt acacgcttaa tgaatatata tgtaacttac atatttaata    10020



ggtgactctt taatttcata acttaagcat taaaaactat acataatgat tattaaatta    10080



aatttagttt ttcaacactc cttaaattta atttcagatc aaaccgagtc ttgctcttaa    10140



tctggcaaaa tcttcaaact ttaatgcctt cgtcaaaata tcagcaagtt gatcttgcga    10200



cttgacatac ttcagctcta tttccttctt acggatactt tctctgatga aatgatatct    10260



tctattaatg tatttactct taacatgtaa aataggattc ttgctcaatg ctatagacga    10320



tttattatca ataaaaatat caattggttc ttcgtttgaa accaatagca cctctaacac    10380



ctttcttaac catgtggcat gacaaacaca agcagcagca acaacatact taacttcaca    10440



agttgaaaga attacaatag attacttctt tgaactccat gtaaaagcag tctctccaat    10500



agaaaacaca aaacccattg tactctttcg atcatcaata tcacctcctc aatcactatc    10560



actatagcct actagactga aactttttga aggtgagtaa aacaaaccat aatctaaagt    10620



tccttcgaca tatctcaaaa ttcttttacc agccttcatg tgcgaatctg ttggtgcctc    10680



catgtagcga ctaataagtc ctactccata aagaatatca ggtctagtac aagtcaagta    10740



cctcaagttt ccaacaaatc tttgaaacaa aattggattc accttctcag tattatcata    10800



tcttgacagc tttactccac attcaactag tgtgctgaca agctgacatt gctccatgcc    10860



aaactccttt aagatctttc ttacatagct cttgtgagaa ataaaaatgc catcattagt    10920



ttgtttcact ttgattccca gataataaga catcaaccct atatctgtca tctcaaattc    10980



agcagccatc tcctttttga attattcaat cattgctgaa ttatttttct gtaaagatca    11040



aatcatcaac atacaagcac accacaagaa catcaccatt ctctttcttc ttagaataaa    11100



gagaatattc atgaggatat ttcagaaaat ttttcttttt gaaataatca tcaatcctgt    11160



tgtaccatgc ccttagtact tgcttcaatc catacaaagg taccttcagt tttaaaactt    11220



tgttttcttc ccctctaaca acatatctga aaggttgttt tagatatcct tcttcttcta    11280



agtatccatt caagaacgcc gatttcacgt ccatttgaaa aattcttcat ctcttttgtg    11340



cagctaaagc aatgattaaa caaattattt ccaatcgagc aactactaca aagacttcat    11400



catagtcaat tccatgttgt tggctaaacc cttttgcaac aagtcgagcc ttgtatttct    11460



cgacatctcc gttttcattc tttttaactt tttataaatc catttcacac caacaacttg    11520



cttgccttag gaaagattgc taattcccaa gtgtcattct tttgaattga ttttatttcg    11580



tcatctatgg ctactctcca tttttcattt ttcatcgctt cttcaaaatt cattggttca    11640



gtatctgcag aaatacaata atgaacaaaa tctaaaactt catcaatgtt agcatatatg    11700



tcctacagat ttctcatctt tgtaggtttt tcagatgatc ttgaacgact tgaatctcct    11760



tgaatacttg ctggagttct tggaagtgtc aagttctgta catcaaaatt aaaatgttga    11820



acatcttgat ctgaataatc aaaaattgga aaaaaattat aattttctga ttgattctcc    11880



caatttcatc catcagcttc ctcaaacttg acatctcgac tcaggataat ctttttgctt    11940



gtcggattgt acaacttgta gactttagac tttgcatcat atccaacaaa aatgaatttt    12000



ccacttttat catccagctt aattctggtt tcatctgcaa catgaacata agcaacataa    12060



ccaaaaactc taagatgaga aagagttggc tttcttccac tccatgcttc ctgtggtata    12120



gacttctgca aactctttat aggacatatg                                     12150





<210>  452

<211>  345

<212>  PRT

<213>  Artificial sequence



<220>

<223>  PE38KDEL



<400>  452



Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu 

1               5                   10                  15      





Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 

            20                  25                  30          





Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 

        35                  40                  45              





Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala 

    50                  55                  60                  





Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu 

65                  70                  75                  80  





Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser 

                85                  90                  95      





Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala 

            100                 105                 110         





Asn Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 

        115                 120                 125             





Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr 

    130                 135                 140                 





Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg 

145                 150                 155                 160 





Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe 

                165                 170                 175     





Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser 

            180                 185                 190         





Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro 

        195                 200                 205             





Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly 

    210                 215                 220                 





Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser 

225                 230                 235                 240 





Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala 

                245                 250                 255     





Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu 

            260                 265                 270         





Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile 

        275                 280                 285             





Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile 

    290                 295                 300                 





Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile 

305                 310                 315                 320 





Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln 

                325                 330                 335     





Pro Gly Lys Pro Pro Lys Asp Glu Leu 

            340                 345 





<210>  453

<211>  1035

<212>  DNA

<213>  Artificial sequence



<220>

<223>  PE38KDEL coding sequence



<400>  453

gagggcggca gcctggccgc gctgaccgcg caccaggctt gccacctgcc gctggagact       60



ttcacccgtc atcgccagcc gcgcggctgg gaacaactgg agcagtgcgg ctatccggtg      120



cagcggctgg tcgccctcta cctggcggcg cggctgtcgt ggaaccaggt cgaccaggtg      180



atccgcaacg ccctggccag ccccggcagc ggcggcgacc tgggcgaagc gatccgcgag      240



cagccggagc aggcccgtct ggccctgacc ctggccgccg ccgagagcga gcgcttcgtc      300



cggcagggca ccggcaacga cgaggccggc gcggccaacg gcccggcgga cagcggcgac      360



gccctgctgg agcgcaacta tcccactggc gcggagttcc tcggcgacgg cggcgacgtc      420



agcttcagca cccgcggcac gcagaactgg acggtggagc ggctgctcca ggcgcaccgc      480



caactggagg agcgcggcta tgtgttcgtc ggctaccacg gcaccttcct cgaagcggcg      540



caaagcatcg tcttcggcgg ggtgcgcgcg cgcagccagg acctcgacgc gatctggcgc      600



ggtttctata tcgccggcga tccggcgctg gcctacggct acgcccagga ccaggaaccc      660



gacgcacgcg gccggatccg caacggtgcc ctgctgcggg tctatgtgcc gcgctcgagc      720



ctgccgggct tctaccgcac cagcctgacc ctggccgcgc cggaggcggc gggcgaggtc      780



gaacggctga tcggccatcc gctgccgctg cgcctggacg ccatcaccgg ccccgaggag      840



gaaggcgggc gcctggagac cattctcggc tggccgctgg ccgagcgcac cgtggtgatt      900



ccctcggcga tccccaccga cccgcgcaac gtcggcggcg acctcgaccc gtccagcatc      960



cccgacaagg aacaggcgat cagcgccctg ccggactacg ccagccagcc cggcaaaccg     1020



ccgaaagacg agctc                                                      1035





<210>  454

<211>  31

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  454

ttaagcgttg gcgcatatgg aagttggttg g                                      31





<210>  455

<211>  98

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  455

ttaagcgttg gcggaattct tatcagcggt gattccacac catcttctgg gcgtccagga       60



tatggtgcag agacccggga ttggtgatcg gagtatag                               98





<210>  456

<211>  32

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  456

ttaagcgttg gcgcatatgg gggacacccg ag                                     32





