                         SEQUENCE LISTING

<110>  MORGAN, Richard A.
       CHINNASAMY, Nachimuthu
       ROSENBERG, Steven  A.
       WARGO, Jennifer A.
 
<120>  ANTI-MAGE-A3 T CELL RECEPTORS AND RELATED MATERIALS AND METHODS 
       OF USE

<130>  708842

<150>  US 61/405,668
<151>  2010-10-22

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  314
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 complete protein sequence.

<400>  1

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Val Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120.

<400>  2

Lys Val Ala Glu Leu Val His Phe Leu 
1               5                   


<210>  3
<211>  314
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A12 complete protein sequence.

<400>  3

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Gln Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Thr Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Arg Glu Val Pro Ala Ala Glu Ser Pro Ser Pro Pro His Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Thr Leu Pro Thr Thr Ile Asn Tyr Thr Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Asp Glu Gly Ser Ser Asn Glu Glu Gln Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Thr Ser Phe Gln Val Ala Leu Ser Arg Lys 
            100                 105                 110         


Met Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Phe Thr Lys Ala Glu Met Leu Gly Ser Val Ile Arg Asn Phe Gln 
    130                 135                 140                 


Asp Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Glu Tyr Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Val Val Glu Val Val Arg Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Val Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Lys Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Ala Ser Asp Gly Arg Glu Asp Ser Val Phe Ala 
225                 230                 235                 240 


His Pro Arg Lys Leu Leu Thr Gln Asp Leu Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Leu Leu Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Ala Phe Arg Glu Gly Glu Glu 
305                 310                 


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A12  peptide.

<400>  4

Lys Met Ala Glu Leu Val His Phe Leu 
1               5                   


<210>  5
<211>  314
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A2 complete protein sequence.

<400>  5

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Gln Thr Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Asp Ser Pro Ser Pro Pro His Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Phe Ser Thr Thr Ile Asn Tyr Thr Leu Trp 
65                  70                  75                  80  


Arg Gln Ser Asp Glu Gly Ser Ser Asn Gln Glu Glu Glu Gly Pro Arg 
                85                  90                  95      


Met Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Ile Ser Arg Lys 
            100                 105                 110         


Met Val Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Glu Ser Val Leu Arg Asn Cys Gln 
    130                 135                 140                 


Asp Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Glu Tyr Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Val Val Glu Val Val Pro Ile Ser His Leu Tyr 
                165                 170                 175     


Ile Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Val Met Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Ile Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Met Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Val Phe Ala 
225                 230                 235                 240 


His Pro Arg Lys Leu Leu Met Gln Asp Leu Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Ile Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Thr Leu Lys Ile Gly Gly Glu Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Arg Ala Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A2 peptide.

<400>  6

Lys Met Val Glu Leu Val His Phe Leu 
1               5                   


<210>  7
<211>  314
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A6 complete protein sequence.

<400>  7

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Lys Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Asp Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Val Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Thr Gly Phe Leu Ile Ile Ile Leu Ala Ile 
        195                 200                 205             


Ile Ala Lys Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Phe Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln Tyr Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Ile Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro Arg Ile Ser Tyr Pro Leu Leu 
    290                 295                 300                 


His Glu Trp Ala Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A6 peptide.

<400>  8

Lys Val Ala Lys Leu Val His Phe Leu 
1               5                   


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR1 alpha amino acid sequence .

<400>  9

Thr Ile Tyr Ser Asn Pro Phe 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR2 alpha amino acid sequence.

<400>  10

Ser Phe Thr Asp Asn Lys Arg 
1               5           


<210>  11
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR3 alpha amino acid sequence (wild type).

<400>  11

Cys Ala Phe Asp Thr Asn Ala Tyr Lys Val Ile Phe 
1               5                   10          


<210>  12
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR1 beta amino acid sequence.

<400>  12

Met Ser His Glu Thr 
1               5   


<210>  13
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR2 beta amino acid sequence.

<400>  13

Ser Tyr Asp Val Asp Ser 
1               5       


<210>  14
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR3 beta amino acid sequence.

<400>  14

Ala Ser Ser Ser Thr Asn Thr Glu Val Phe 
1               5                   10  


<210>  15
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 variable region alpha chain (wild type) amino 
       acid sequence.

<400>  15

Met Gly Pro Val Thr Cys Ser Val Leu Val Leu Leu Leu Met Leu Arg 
1               5                   10                  15      


Arg Ser Asn Gly Asp Gly Asp Ser Val Thr Gln Thr Glu Gly Leu Val 
            20                  25                  30          


Thr Leu Thr Glu Gly Leu Pro Val Met Leu Asn Cys Thr Tyr Gln Thr 
        35                  40                  45              


Ile Tyr Ser Asn Pro Phe Leu Phe Trp Tyr Val Gln His Leu Asn Glu 
    50                  55                  60                  


Ser Pro Arg Leu Leu Leu Lys Ser Phe Thr Asp Asn Lys Arg Thr Glu 
65                  70                  75                  80  


His Gln Gly Phe His Ala Thr Leu His Lys Ser Ser Ser Ser Phe His 
                85                  90                  95      


Leu Gln Lys Ser Ser Ala Gln Leu Ser Asp Ser Ala Leu Tyr Tyr Cys 
            100                 105                 110         


Ala Phe Asp Thr Asn Ala Tyr Lys Val Ile Phe 
        115                 120             


<210>  16
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 variable region beta chain amino acid sequence.

<400>  16

Met Arg Val Arg Leu Ile Ser Ala Val Val Leu Cys Ser Leu Gly Thr 
1               5                   10                  15      


Gly Leu Val Asp Met Lys Val Thr Gln Met Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Arg Met Gly Glu Asn Val Leu Leu Glu Cys Gly Gln Asp Met Ser His 
        35                  40                  45              


Glu Thr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Gln Leu 
    50                  55                  60                  


Ile Tyr Ile Ser Tyr Asp Val Asp Ser Asn Ser Glu Gly Asp Ile Pro 
65                  70                  75                  80  


Lys Gly Tyr Arg Val Ser Arg Lys Lys Arg Glu His Phe Ser Leu Ile 
                85                  90                  95      


Leu Asp Ser Ala Lys Thr Asn Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ser Thr Asn Thr Glu Val Phe 
        115                 120 


<210>  17
<211>  271
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 alpha chain (wild type) amino acid sequence.

<400>  17

Met Gly Pro Val Thr Cys Ser Val Leu Val Leu Leu Leu Met Leu Arg 
1               5                   10                  15      


Arg Ser Asn Gly Asp Gly Asp Ser Val Thr Gln Thr Glu Gly Leu Val 
            20                  25                  30          


Thr Leu Thr Glu Gly Leu Pro Val Met Leu Asn Cys Thr Tyr Gln Thr 
        35                  40                  45              


Ile Tyr Ser Asn Pro Phe Leu Phe Trp Tyr Val Gln His Leu Asn Glu 
    50                  55                  60                  


Ser Pro Arg Leu Leu Leu Lys Ser Phe Thr Asp Asn Lys Arg Thr Glu 
65                  70                  75                  80  


His Gln Gly Phe His Ala Thr Leu His Lys Ser Ser Ser Ser Phe His 
                85                  90                  95      


Leu Gln Lys Ser Ser Ala Gln Leu Ser Asp Ser Ala Leu Tyr Tyr Cys 
            100                 105                 110         


Ala Phe Asp Thr Asn Ala Tyr Lys Val Ile Phe Gly Lys Gly Thr His 
        115                 120                 125             


Leu His Val Leu Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Thr Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Leu 
            260                 265                 270     


<210>  18
<211>  303
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 beta chain amino acid sequence.

<400>  18

Met Arg Val Arg Leu Ile Ser Ala Val Val Leu Cys Ser Leu Gly Thr 
1               5                   10                  15      


Gly Leu Val Asp Met Lys Val Thr Gln Met Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Arg Met Gly Glu Asn Val Leu Leu Glu Cys Gly Gln Asp Met Ser His 
        35                  40                  45              


Glu Thr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Gln Leu 
    50                  55                  60                  


Ile Tyr Ile Ser Tyr Asp Val Asp Ser Asn Ser Glu Gly Asp Ile Pro 
65                  70                  75                  80  


Lys Gly Tyr Arg Val Ser Arg Lys Lys Arg Glu His Phe Ser Leu Ile 
                85                  90                  95      


Leu Asp Ser Ala Lys Thr Asn Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ser Thr Asn Thr Glu Val Phe Phe Gly Lys Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala 
            180                 185                 190         


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300             


<210>  19
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Linker peptide amino acid sequence.

<400>  19

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25          


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR3 alpha substituted amino acid sequence.

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa at 7 is Thr or Val.

<400>  20

Cys Ala Phe Asp Thr Asn Xaa Tyr Lys Val Ile Phe 
1               5                   10          


<210>  21
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 variable region alpha chain amino acid sequence 
       substituted.

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa at 118 is Thr or Val.

<400>  21

Met Gly Pro Val Thr Cys Ser Val Leu Val Leu Leu Leu Met Leu Arg 
1               5                   10                  15      


Arg Ser Asn Gly Asp Gly Asp Ser Val Thr Gln Thr Glu Gly Leu Val 
            20                  25                  30          


Thr Leu Thr Glu Gly Leu Pro Val Met Leu Asn Cys Thr Tyr Gln Thr 
        35                  40                  45              


Ile Tyr Ser Asn Pro Phe Leu Phe Trp Tyr Val Gln His Leu Asn Glu 
    50                  55                  60                  


Ser Pro Arg Leu Leu Leu Lys Ser Phe Thr Asp Asn Lys Arg Thr Glu 
65                  70                  75                  80  


His Gln Gly Phe His Ala Thr Leu His Lys Ser Ser Ser Ser Phe His 
                85                  90                  95      


Leu Gln Lys Ser Ser Ala Gln Leu Ser Asp Ser Ala Leu Tyr Tyr Cys 
            100                 105                 110         


Ala Phe Asp Thr Asn Xaa Tyr Lys Val Ile Phe 
        115                 120             


<210>  22
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 substituted whole alpha chain amino acid 
       sequence.

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa at 118 is Thr or Val.

<400>  22

Met Gly Pro Val Thr Cys Ser Val Leu Val Leu Leu Leu Met Leu Arg 
1               5                   10                  15      


Arg Ser Asn Gly Asp Gly Asp Ser Val Thr Gln Thr Glu Gly Leu Val 
            20                  25                  30          


Thr Leu Thr Glu Gly Leu Pro Val Met Leu Asn Cys Thr Tyr Gln Thr 
        35                  40                  45              


Ile Tyr Ser Asn Pro Phe Leu Phe Trp Tyr Val Gln His Leu Asn Glu 
    50                  55                  60                  


Ser Pro Arg Leu Leu Leu Lys Ser Phe Thr Asp Asn Lys Arg Thr Glu 
65                  70                  75                  80  


His Gln Gly Phe His Ala Thr Leu His Lys Ser Ser Ser Ser Phe His 
                85                  90                  95      


Leu Gln Lys Ser Ser Ala Gln Leu Ser Asp Ser Ala Leu Tyr Tyr Cys 
            100                 105                 110         


Ala Phe Asp Thr Asn Xaa Tyr Lys Val Ile Phe Gly Lys Gly Thr His 
        115                 120                 125             


Leu His Val Leu Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Thr Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Leu 
            260                 265                 270     


<210>  23
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR1 alpha amino acid sequence.

<400>  23

Tyr Ser Ala Ala Pro Tyr 
1               5       


<210>  24
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR2 alpha amino acid sequence.

<400>  24

Tyr Ile Thr Gly Asp Thr Val Val 
1               5               


<210>  25
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR3 alpha amino acid sequence.

<400>  25

Cys Ala Leu Glu Gly Pro Asp Thr Gly Asn Tyr Lys Tyr Val 
1               5                   10                  


<210>  26
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR1 beta amino acid sequence.

<400>  26

Ser Gly His Asn Asp 
1               5   


<210>  27
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR2 beta amino acid sequence.

<400>  27

Phe Arg Ser Lys Ser Leu 
1               5       


<210>  28
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR3 beta amino acid sequence.

<400>  28

Ala Ser Ser Phe Gly Thr Ala Ser Ala Glu Thr Leu Tyr 
1               5                   10              


<210>  29
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 variable region alpha chain amino acid sequence.

<400>  29

Met Val Leu Val Thr Ile Leu Leu Leu Ser Ala Phe Phe Ser Leu Arg 
1               5                   10                  15      


Gly Asn Ser Ala Gln Ser Val Asp Gln Pro Asp Ala His Val Thr Leu 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Ser Tyr Ser Tyr Ser Ala 
        35                  40                  45              


Ala Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln Ser Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Thr Val Val Lys Gly Thr Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Arg Lys Ser Asn Ser Ser Phe Asn Leu Lys 
                85                  90                  95      


Lys Ser Pro Ala His Trp Ser Asp Ser Ala Lys Tyr Phe Cys Ala Leu 
            100                 105                 110         


Glu Gly Pro Asp Thr Gly Asn Tyr Lys Tyr Val 
        115                 120             


<210>  30
<211>  124
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 variable region beta chain amino acid sequence.

<400>  30

Met Gly Ile Gln Thr Leu Cys Cys Val Ile Phe Tyr Val Leu Ile Ala 
1               5                   10                  15      


Asn His Thr Asp Ala Gly Val Thr Gln Thr Pro Arg His Glu Val Ala 
            20                  25                  30          


Glu Lys Gly Gln Thr Ile Ile Leu Lys Cys Glu Pro Val Ser Gly His 
        35                  40                  45              


Asn Asp Leu Phe Trp Tyr Arg Gln Thr Lys Ile Gln Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ser Tyr Phe Arg Ser Lys Ser Leu Met Glu Asp Gly Gly Ala Phe 
65                  70                  75                  80  


Lys Asp Arg Phe Lys Ala Glu Met Leu Asn Ser Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Thr Glu Pro Arg Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Phe Gly Thr Ala Ser Ala Glu Thr Leu Tyr 
        115                 120                 


<210>  31
<211>  271
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 whole alpha chain amino acid sequence.

<400>  31

Met Val Leu Val Thr Ile Leu Leu Leu Ser Ala Phe Phe Ser Leu Arg 
1               5                   10                  15      


Gly Asn Ser Ala Gln Ser Val Asp Gln Pro Asp Ala His Val Thr Leu 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Ser Tyr Ser Tyr Ser Ala 
        35                  40                  45              


Ala Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln Ser Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Thr Val Val Lys Gly Thr Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Arg Lys Ser Asn Ser Ser Phe Asn Leu Lys 
                85                  90                  95      


Lys Ser Pro Ala His Trp Ser Asp Ser Ala Lys Tyr Phe Cys Ala Leu 
            100                 105                 110         


Glu Gly Pro Asp Thr Gly Asn Tyr Lys Tyr Val Phe Gly Ala Gly Thr 
        115                 120                 125             


Arg Leu Lys Val Ile Ala His Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  32
<211>  306
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 whole beta chain amino acid sequence.

<400>  32

Met Gly Ile Gln Thr Leu Cys Cys Val Ile Phe Tyr Val Leu Ile Ala 
1               5                   10                  15      


Asn His Thr Asp Ala Gly Val Thr Gln Thr Pro Arg His Glu Val Ala 
            20                  25                  30          


Glu Lys Gly Gln Thr Ile Ile Leu Lys Cys Glu Pro Val Ser Gly His 
        35                  40                  45              


Asn Asp Leu Phe Trp Tyr Arg Gln Thr Lys Ile Gln Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ser Tyr Phe Arg Ser Lys Ser Leu Met Glu Asp Gly Gly Ala Phe 
65                  70                  75                  80  


Lys Asp Arg Phe Lys Ala Glu Met Leu Asn Ser Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Thr Glu Pro Arg Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Phe Gly Thr Ala Ser Ala Glu Thr Leu Tyr Phe Gly Ser Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  33
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR1 alpha nucleic acid sequence.

<400>  33
actatttact caaatccttt c                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR2 alpha nucleic acid sequence.

<400>  34
agcttcacag acaacaagag g                                                 21


<210>  35
<211>  36
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR3 alpha nucleic acid sequence (wild type).

<400>  35
tgtgctttcg acacaaatgc ttacaaagtc atcttt                                 36


<210>  36
<211>  15
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR1 beta nucleic acid sequence.

<400>  36
atgagccatg aaaca                                                        15


<210>  37
<211>  18
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR2 beta nucleic acid sequence.

<400>  37
tcatacgatg ttgatagt                                                     18


<210>  38
<211>  36
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR3 beta nucleic acid sequence.

<400>  38
tgtgctagca gttcaacaaa cacagaagtc ttcttt                                 36


<210>  39
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 variable region alpha chain (wild type) nucleic 
       acid sequence.

<400>  39
atgggtcctg tcacctgctc agttcttgtg ctcctcctaa tgctcaggag gagcaatggc       60

gatggagact ccgtgaccca gacagaaggc ctggtcactc tcacagaagg gttgcctgtg      120

atgctgaact gcacctatca gactatttac tcaaatcctt tccttttctg gtatgtgcaa      180

catctcaatg aatcccctcg gctactcctg aagagcttca cagacaacaa gaggaccgag      240

caccaagggt tccacgccac tctccataag agcagcagct ccttccatct gcagaagtcc      300

tcagcgcagc tgtcagactc tgccctgtac tactgtgctt tcgacacaaa tgcttacaaa      360

gtcatcttt                                                              369


<210>  40
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 variable region beta chain nucleic acid sequence.

<400>  40
atgagagtta ggctcatctc tgctgtggtg ctgtgttccc taggaacagg ccttgtggac       60

atgaaagtaa cccagatgcc aagatacctg atcaaaagaa tgggagagaa tgttttgctg      120

gaatgtggac aggacatgag ccatgaaaca atgtactggt atcgacaaga ccctggtctg      180

gggctacagc tgatttatat ctcatacgat gttgatagta acagcgaagg agacatccct      240

aaaggataca gggtctcacg gaagaagcgg gagcatttct ccctgattct ggattctgct      300

aaaacaaacc agacatctgt gtacttctgt gctagcagtt caacaaacac agaagtcttc      360

ttt                                                                    363


<210>  41
<211>  813
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 whole alpha chain (wild type) nucleic acid 
       sequence.

<400>  41
atgggtcctg tcacctgctc agttcttgtg ctcctcctaa tgctcaggag gagcaatggc       60

gatggagact ccgtgaccca gacagaaggc ctggtcactc tcacagaagg gttgcctgtg      120

atgctgaact gcacctatca gactatttac tcaaatcctt tccttttctg gtatgtgcaa      180

catctcaatg aatcccctcg gctactcctg aagagcttca cagacaacaa gaggaccgag      240

caccaagggt tccacgccac tctccataag agcagcagct ccttccatct gcagaagtcc      300

tcagcgcagc tgtcagactc tgccctgtac tactgtgctt tcgacacaaa tgcttacaaa      360

gtcatctttg gaaaagggac acatcttcat gttctcccta acatccagaa cccagaacct      420

gctgtgtacc agttaaaaga tcctcggtct caggacagca ccctctgcct gttcaccgac      480

tttgactccc aaatcaatgt gccgaaaacc atggaatctg gaacgttcat cactgacaaa      540

actgtgctgg acatgaaagc tatggattcc aagagcaatg gggccattgc ctggagcaac      600

cagacaagct tcacctgcca agatatcttc aaagagacca acaccaccta ccccagttca      660

gacgttccct gtgatgccac gttgactgag aaaagctttg aaacagatat gaacctaaac      720

tttcaaaacc tgtcagttat gggactccga atcctcctgc tgaaagtagc cggatttaac      780

ctgctcatga cgctgaggct gtggtccagt tga                                   813


<210>  42
<211>  912
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 whole beta chain nucleic acid sequence.

<400>  42
atgagagtta ggctcatctc tgctgtggtg ctgtgttccc taggaacagg ccttgtggac       60

atgaaagtaa cccagatgcc aagatacctg atcaaaagaa tgggagagaa tgttttgctg      120

gaatgtggac aggacatgag ccatgaaaca atgtactggt atcgacaaga ccctggtctg      180

gggctacagc tgatttatat ctcatacgat gttgatagta acagcgaagg agacatccct      240

aaaggataca gggtctcacg gaagaagcgg gagcatttct ccctgattct ggattctgct      300

aaaacaaacc agacatctgt gtacttctgt gctagcagtt caacaaacac agaagtcttc      360

tttggtaaag gaaccagact cacagttgta gaggatctga gaaatgtgac tccacccaag      420

gtctccttgt ttgagccatc aaaagcagag attgcaaaca aacaaaaggc taccctcgtg      480

tgcttggcca ggggcttctt ccctgaccac gtggagctga gctggtgggt gaatggcaag      540

gaggtccaca gtggggtcag cacggaccct caggcctaca aggagagcaa ttatagctac      600

tgcctgagca gccgcctgag ggtctctgct accttctggc acaatcctcg caaccacttc      660

cgctgccaag tgcagttcca tgggctttca gaggaggaca agtggccaga gggctcaccc      720

aaacctgtca cacagaacat cagtgcagag gcctggggcc gagcagactg tgggattacc      780

tcagcatcct atcaacaagg ggtcttgtct gccaccatcc tctatgagat cctgctaggg      840

aaagccaccc tgtatgctgt gcttgtcagt acactggtgg tgatggctat ggtcaaaaga      900

aagaactcgt ga                                                          912


<210>  43
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Linker peptide nucleic acid sequence.

<400>  43
cgggccaagc ggtccggatc cggagccacc aacttcagcc tgctgaagca ggccggcgac       60

gtggaggaga accccggccc c                                                 81


<210>  44
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 CDR3 alpha substituted nucleic acid sequence.

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Nnn at positions 19-21 is ACA, ACC, ACG, ACT, GTA, GTC, GTG, or 
       GTT.

<400>  44
tgtgctttcg acacaaatnn ntacaaagtc atcttt                                 36


<210>  45
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 variable region alpha chain nucleic acid sequence
       substituted.

<220>
<221>  misc_feature
<222>  (352)..(354)
<223>  Nnn at positions 352-354 is ACA, ACC, ACG, ACT, GTA, GTC, GTG, or
       GTT.

<400>  45
atgggtcctg tcacctgctc agttcttgtg ctcctcctaa tgctcaggag gagcaatggc       60

gatggagact ccgtgaccca gacagaaggc ctggtcactc tcacagaagg gttgcctgtg      120

atgctgaact gcacctatca gactatttac tcaaatcctt tccttttctg gtatgtgcaa      180

catctcaatg aatcccctcg gctactcctg aagagcttca cagacaacaa gaggaccgag      240

caccaagggt tccacgccac tctccataag agcagcagct ccttccatct gcagaagtcc      300

tcagcgcagc tgtcagactc tgccctgtac tactgtgctt tcgacacaaa tnnntacaaa      360

gtcatcttt                                                              369


<210>  46
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 substituted whole alpha chain nucleic acid 
       sequence.

<220>
<221>  misc_feature
<222>  (352)..(354)
<223>  Nnn at positions 352-354 is ACA, ACC, ACG, ACT, GTA, GTC, GTG, or
       GTT.

<400>  46
atgggtcctg tcacctgctc agttcttgtg ctcctcctaa tgctcaggag gagcaatggc       60

gatggagact ccgtgaccca gacagaaggc ctggtcactc tcacagaagg gttgcctgtg      120

atgctgaact gcacctatca gactatttac tcaaatcctt tccttttctg gtatgtgcaa      180

catctcaatg aatcccctcg gctactcctg aagagcttca cagacaacaa gaggaccgag      240

caccaagggt tccacgccac tctccataag agcagcagct ccttccatct gcagaagtcc      300

tcagcgcagc tgtcagactc tgccctgtac tactgtgctt tcgacacaaa tnnntacaaa      360

gtcatctttg gaaaagggac acatcttcat gttctcccta acatccagaa cccagaacct      420

gctgtgtacc agttaaaaga tcctcggtct caggacagca ccctctgcct gttcaccgac      480

tttgactccc aaatcaatgt gccgaaaacc atggaatctg gaacgttcat cactgacaaa      540

actgtgctgg acatgaaagc tatggattcc aagagcaatg gggccattgc ctggagcaac      600

cagacaagct tcacctgcca agatatcttc aaagagacca acaccaccta ccccagttca      660

gacgttccct gtgatgccac gttgactgag aaaagctttg aaacagatat gaacctaaac      720

tttcaaaacc tgtcagttat gggactccga atcctcctgc tgaaagtagc cggatttaac      780

ctgctcatga cgctgaggct gtggtccagt tga                                   813


<210>  47
<211>  18
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR1 alpha nucleic acid sequence.

<400>  47
tacagtgcag caccttac                                                     18


<210>  48
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR2 alpha nucleic acid sequence.

<400>  48
tacatcacag gagacaccgt tgtt                                              24


<210>  49
<211>  45
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR3 alpha nucleic acid sequence.

<400>  49
tgtgcactgg agggcccgga tacaggaaac tacaaatacg tcttt                       45


<210>  50
<211>  15
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR1 beta nucleic acid sequence.

<400>  50
tcaggccaca atgac                                                        15


<210>  51
<211>  18
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR2 beta nucleic acid sequence.

<400>  51
ttccgcagca agtctctt                                                     18


<210>  52
<211>  39
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 CDR3 beta nucleic acid sequence.

<400>  52
gccagcagtt ttgggacagc tagtgcagaa acgctgtat                              39


<210>  53
<211>  371
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 variable region alpha chain nucleic acid 
       sequence.

<400>  53
atggtcctag tgaccattct gctgctcagc gcgttcttct cactgagagg aaacagtgcc       60

cagtccgtgg accagcctga tgctcatgtc acgctctctg aaggagcctc cctggagctc      120

agatgcagtt attcatacag tgcagcacct tacctcttct ggtacgtgca gtatcctggc      180

cagagcctcc agtttctcct caaatacatc acaggagaca ccgttgttaa aggcaccaag      240

ggctttgagg ccgagtttag gaagagtaac tcctctttca acctgaagaa atccccagcc      300

cattggagcg actcagccaa gtacttctgt gcactggagg gcccggatac aggaaactac      360

aaatacgtct t                                                           371


<210>  54
<211>  375
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 variable region beta chain nucleic acid sequence.

<400>  54
atgggcatcc agaccctctg ttgtgtgatc ttttatgttc tgatagcaaa tcacacagat       60

gctggagtta cccagacacc cagacatgag gtggcagaga aaggacaaac aataatcctg      120

aagtgtgagc cagtttcagg ccacaatgac cttttctggt acagacagac caagatacag      180

ggactagagt tgctgagcta cttccgcagc aagtctctta tggaagatgg tggggctttc      240

aaggatcgat tcaaagctga gatgctaaat tcatccttct ccactctgaa gattcaacct      300

acagaaccca gggactcagc tgtgtatctg tgtgccagca gttttgggac agctagtgca      360

gaaacgctgt atttt                                                       375


<210>  55
<211>  816
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 whole alpha chain nucleic acid sequence.

<400>  55
atggtcctag tgaccattct gctgctcagc gcgttcttct cactgagagg aaacagtgcc       60

cagtccgtgg accagcctga tgctcatgtc acgctctctg aaggagcctc cctggagctc      120

agatgcagtt attcatacag tgcagcacct tacctcttct ggtacgtgca gtatcctggc      180

cagagcctcc agtttctcct caaatacatc acaggagaca ccgttgttaa aggcaccaag      240

ggctttgagg ccgagtttag gaagagtaac tcctctttca acctgaagaa atccccagcc      300

cattggagcg actcagccaa gtacttctgt gcactggagg gcccggatac aggaaactac      360

aaatacgtct ttggagcagg taccagactg aaggttatag cacacatcca gaacccagaa      420

cctgctgtgt accagttaaa agatcctcgg tctcaggaca gcaccctctg cctgttcacc      480

gactttgact cccaaatcaa tgtgccgaaa accatggaat ctggaacgtt catcactgac      540

aaaactgtgc tggacatgaa agctatggat tccaagagca atggggccat tgcctggagc      600

aaccagacaa gcttcacctg ccaagatatc ttcaaagaga ccaacgccac ctaccccagt      660

tcagacgttc cctgtgatgc cacgttgact gagaaaagct ttgaaacaga tatgaaccta      720

aacttccaaa acctgtcagt tatgggactc cgaatcctcc tgctgaaagt agccggattt      780

aacctgctca tgacgctgag gctgtggtcc agttga                                816


<210>  56
<211>  924
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 whole beta chain nucleic acid sequence.

<400>  56
atgggcatcc agaccctctg ttgtgtgatc ttttatgttc tgatagcaaa tcacacagat       60

gctggagtta cccagacacc cagacatgag gtggcagaga aaggacaaac aataatcctg      120

aagtgtgagc cagtttcagg ccacaatgac cttttctggt acagacagac caagatacag      180

ggactagagt tgctgagcta cttccgcagc aagtctctta tggaagatgg tggggctttc      240

aaggatcgat tcaaagctga gatgctaaat tcatccttct ccactctgaa gattcaacct      300

acagaaccca gggactcagc tgtgtatctg tgtgccagca gttttgggac agctagtgca      360

gaaacgctgt attttggctc aggaaccaga ctgactgttc tcgaggatct gagaaatgtg      420

actccaccca aggtctcctt gtttgagcca tcaaaagcag agattgcaaa caaacaaaag      480

gctaccctcg tgtgcttggc caggggcttc ttcccctgac acgtggagct gagctggtgg      540

gtgaatggca aggaggtcca cagtggggtc agcacggacc ctcaggccta caaggagagc      600

aattatagct actgcctgag cagccgcctg agggtctctg ctaccttctg gcacaatcct      660

cgaaaccact tccgctgtca agtgcagttc catgggcttt cagaggagga caagtggcca      720

gagggctcac ccaaacctgt cacacagaac atcagtgcag aggcctgggg ccgagcagac      780

tgtggaatca cttcagcatc ctatcatcag ggggttctgt ctgcaaccat cctctatgag      840

atcctactgg ggaaggccac cctatatgct gtgctggtca gtggcctggt gctgatggcc      900

atggtcaaga aaaaaaattc ctga                                             924


<210>  57
<211>  1803
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 wild type alpha and beta chains with linker.

<400>  57
atgggtcctg tcacctgctc agttcttgtg ctcctcctaa tgctcaggag gagcaatggc       60

gatggagact ccgtgaccca gacagaaggc ctggtcactc tcacagaagg gttgcctgtg      120

atgctgaact gcacctatca gactatttac tcaaatcctt tccttttctg gtatgtgcaa      180

catctcaatg aatcccctcg gctactcctg aagagcttca cagacaacaa gaggaccgag      240

caccaagggt tccacgccac tctccataag agcagcagct ccttccatct gcagaagtcc      300

tcagcgcagc tgtcagactc tgccctgtac tactgtgctt tcgacacaaa tgcttacaaa      360

gtcatctttg gaaaagggac acatcttcat gttctcccta acatccagaa cccagaacct      420

gctgtgtacc agttaaaaga tcctcggtct caggacagca ccctctgcct gttcaccgac      480

tttgactccc aaatcaatgt gccgaaaacc atggaatctg gaacgttcat cactgacaaa      540

actgtgctgg acatgaaagc tatggattcc aagagcaatg gggccattgc ctggagcaac      600

cagacaagct tcacctgcca agatatcttc aaagagacca acaccaccta ccccagttca      660

gacgttccct gtgatgccac gttgactgag aaaagctttg aaacagatat gaacctaaac      720

tttcaaaacc tgtcagttat gggactccga atcctcctgc tgaaagtagc cggatttaac      780

ctgctcatga cgctgaggct gtggtccagt cgggccaagc ggtccggatc cggagccacc      840

aacttcagcc tgctgaagca ggccggcgac gtggaggaga accccggccc catgagagtt      900

aggctcatct ctgctgtggt gctgtgttcc ctaggaacag gccttgtgga catgaaagta      960

acccagatgc caagatacct gatcaaaaga atgggagaga atgttttgct ggaatgtgga     1020

caggacatga gccatgaaac aatgtactgg tatcgacaag accctggtct ggggctacag     1080

ctgatttata tctcatacga tgttgatagt aacagcgaag gagacatccc taaaggatac     1140

agggtctcac ggaagaagcg ggagcatttc tccctgattc tggattctgc taaaacaaac     1200

cagacatctg tgtacttctg tgctagcagt tcaacaaaca cagaagtctt ctttggtaaa     1260

ggaaccagac tcacagttgt agaggatctg agaaatgtga ctccacccaa ggtctccttg     1320

tttgagccat caaaagcaga gattgcaaac aaacaaaagg ctaccctcgt gtgcttggcc     1380

aggggcttct tccctgacca cgtggagctg agctggtggg tgaatggcaa ggaggtccac     1440

agtggggtca gcacggaccc tcaggcctac aaggagagca attatagcta ctgcctgagc     1500

agccgcctga gggtctctgc taccttctgg cacaatcctc gcaaccactt ccgctgccaa     1560

gtgcagttcc atgggctttc agaggaggac aagtggccag agggctcacc caaacctgtc     1620

acacagaaca tcagtgcaga ggcctggggc cgagcagact gtgggattac ctcagcatcc     1680

tatcaacaag gggtcttgtc tgccaccatc ctctatgaga tcctgctagg gaaagccacc     1740

ctgtatgctg tgcttgtcag tacactggtg gtgatggcta tggtcaaaag aaagaactcg     1800

tga                                                                   1803


<210>  58
<211>  1803
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE-A3 112-120 substituted alpha chain and beta chain with 
       linker.

<220>
<221>  misc_feature
<222>  (352)..(354)
<223>  Nnn at positions 352-354 is ACA, ACC, ACG, ACT, GTA, GTC, GTG, or
       GTT.

<400>  58
atgggtcctg tcacctgctc agttcttgtg ctcctcctaa tgctcaggag gagcaatggc       60

gatggagact ccgtgaccca gacagaaggc ctggtcactc tcacagaagg gttgcctgtg      120

atgctgaact gcacctatca gactatttac tcaaatcctt tccttttctg gtatgtgcaa      180

catctcaatg aatcccctcg gctactcctg aagagcttca cagacaacaa gaggaccgag      240

caccaagggt tccacgccac tctccataag agcagcagct ccttccatct gcagaagtcc      300

tcagcgcagc tgtcagactc tgccctgtac tactgtgctt tcgacacaaa tnnntacaaa      360

gtcatctttg gaaaagggac acatcttcat gttctcccta acatccagaa cccagaacct      420

gctgtgtacc agttaaaaga tcctcggtct caggacagca ccctctgcct gttcaccgac      480

tttgactccc aaatcaatgt gccgaaaacc atggaatctg gaacgttcat cactgacaaa      540

actgtgctgg acatgaaagc tatggattcc aagagcaatg gggccattgc ctggagcaac      600

cagacaagct tcacctgcca agatatcttc aaagagacca acaccaccta ccccagttca      660

gacgttccct gtgatgccac gttgactgag aaaagctttg aaacagatat gaacctaaac      720

tttcaaaacc tgtcagttat gggactccga atcctcctgc tgaaagtagc cggatttaac      780

ctgctcatga cgctgaggct gtggtccagt cgggccaagc ggtccggatc cggagccacc      840

aacttcagcc tgctgaagca ggccggcgac gtggaggaga accccggccc catgagagtt      900

aggctcatct ctgctgtggt gctgtgttcc ctaggaacag gccttgtgga catgaaagta      960

acccagatgc caagatacct gatcaaaaga atgggagaga atgttttgct ggaatgtgga     1020

caggacatga gccatgaaac aatgtactgg tatcgacaag accctggtct ggggctacag     1080

ctgatttata tctcatacga tgttgatagt aacagcgaag gagacatccc taaaggatac     1140

agggtctcac ggaagaagcg ggagcatttc tccctgattc tggattctgc taaaacaaac     1200

cagacatctg tgtacttctg tgctagcagt tcaacaaaca cagaagtctt ctttggtaaa     1260

ggaaccagac tcacagttgt agaggatctg agaaatgtga ctccacccaa ggtctccttg     1320

tttgagccat caaaagcaga gattgcaaac aaacaaaagg ctaccctcgt gtgcttggcc     1380

aggggcttct tccctgacca cgtggagctg agctggtggg tgaatggcaa ggaggtccac     1440

agtggggtca gcacggaccc tcaggcctac aaggagagca attatagcta ctgcctgagc     1500

agccgcctga gggtctctgc taccttctgg cacaatcctc gcaaccactt ccgctgccaa     1560

gtgcagttcc atgggctttc agaggaggac aagtggccag agggctcacc caaacctgtc     1620

acacagaaca tcagtgcaga ggcctggggc cgagcagact gtgggattac ctcagcatcc     1680

tatcaacaag gggtcttgtc tgccaccatc ctctatgaga tcctgctagg gaaagccacc     1740

ctgtatgctg tgcttgtcag tacactggtg gtgatggcta tggtcaaaag aaagaactcg     1800

tga                                                                   1803


<210>  59
<211>  1818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 alpha and beta chains with linker.

<400>  59
atggtcctag tgaccattct gctgctcagc gcgttcttct cactgagagg aaacagtgcc       60

cagtccgtgg accagcctga tgctcatgtc acgctctctg aaggagcctc cctggagctc      120

agatgcagtt attcatacag tgcagcacct tacctcttct ggtacgtgca gtatcctggc      180

cagagcctcc agtttctcct caaatacatc acaggagaca ccgttgttaa aggcaccaag      240

ggctttgagg ccgagtttag gaagagtaac tcctctttca acctgaagaa atccccagcc      300

cattggagcg actcagccaa gtacttctgt gcactggagg gcccggatac aggaaactac      360

aaatacgtct ttggagcagg taccagactg aaggttatag cacacatcca gaacccagaa      420

cctgctgtgt accagttaaa agatcctcgg tctcaggaca gcaccctctg cctgttcacc      480

gactttgact cccaaatcaa tgtgccgaaa accatggaat ctggaacgtt catcactgac      540

aaaactgtgc tggacatgaa agctatggat tccaagagca atggggccat tgcctggagc      600

aaccagacaa gcttcacctg ccaagatatc ttcaaagaga ccaacgccac ctaccccagt      660

tcagacgttc cctgtgatgc cacgttgact gagaaaagct ttgaaacaga tatgaaccta      720

aacttccaaa acctgtcagt tatgggactc cgaatcctcc tgctgaaagt agccggattt      780

aacctgctca tgacgctgag gctgtggtcc agtcgggcca agcggtccgg atccggagcc      840

accaacttca gcctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccatgggc      900

atccagaccc tctgttgtgt gatcttttat gttctgatag caaatcacac agatgctgga      960

gttacccaga cacccagaca tgaggtggca gagaaaggac aaacaataat cctgaagtgt     1020

gagccagttt caggccacaa tgaccttttc tggtacagac agaccaagat acagggacta     1080

gagttgctga gctacttccg cagcaagtct cttatggaag atggtggggc tttcaaggat     1140

cgattcaaag ctgagatgct aaattcatcc ttctccactc tgaagattca acctacagaa     1200

cccagggact cagctgtgta tctgtgtgcc agcagttttg ggacagctag tgcagaaacg     1260

ctgtattttg gctcaggaac cagactgact gttctcgagg atctgagaaa tgtgactcca     1320

cccaaggtct ccttgtttga gccatcaaaa gcagagattg caaacaaaca aaaggctacc     1380

ctcgtgtgct tggccagggg cttcttcccc tgacacgtgg agctgagctg gtgggtgaat     1440

ggcaaggagg tccacagtgg ggtcagcacg gaccctcagg cctacaagga gagcaattat     1500

agctactgcc tgagcagccg cctgagggtc tctgctacct tctggcacaa tcctcgaaac     1560

cacttccgct gtcaagtgca gttccatggg ctttcagagg aggacaagtg gccagagggc     1620

tcacccaaac ctgtcacaca gaacatcagt gcagaggcct ggggccgagc agactgtgga     1680

atcacttcag catcctatca tcagggggtt ctgtctgcaa ccatcctcta tgagatccta     1740

ctggggaagg ccaccctata tgctgtgctg gtcagtggcc tggtgctgat ggccatggtc     1800

aagaaaaaaa attcctga                                                   1818


<210>  60
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE 112-120 alpha and beta chains with linker.

<400>  60

Met Gly Pro Val Thr Cys Ser Val Leu Val Leu Leu Leu Met Leu Arg 
1               5                   10                  15      


Arg Ser Asn Gly Asp Gly Asp Ser Val Thr Gln Thr Glu Gly Leu Val 
            20                  25                  30          


Thr Leu Thr Glu Gly Leu Pro Val Met Leu Asn Cys Thr Tyr Gln Thr 
        35                  40                  45              


Ile Tyr Ser Asn Pro Phe Leu Phe Trp Tyr Val Gln His Leu Asn Glu 
    50                  55                  60                  


Ser Pro Arg Leu Leu Leu Lys Ser Phe Thr Asp Asn Lys Arg Thr Glu 
65                  70                  75                  80  


His Gln Gly Phe His Ala Thr Leu His Lys Ser Ser Ser Ser Phe His 
                85                  90                  95      


Leu Gln Lys Ser Ser Ala Gln Leu Ser Asp Ser Ala Leu Tyr Tyr Cys 
            100                 105                 110         


Ala Phe Asp Thr Asn Ala Tyr Lys Val Ile Phe Gly Lys Gly Thr His 
        115                 120                 125             


Leu His Val Leu Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Thr Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala 
            260                 265                 270         


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Val Arg Leu Ile Ser 
    290                 295                 300                 


Ala Val Val Leu Cys Ser Leu Gly Thr Gly Leu Val Asp Met Lys Val 
305                 310                 315                 320 


Thr Gln Met Pro Arg Tyr Leu Ile Lys Arg Met Gly Glu Asn Val Leu 
                325                 330                 335     


Leu Glu Cys Gly Gln Asp Met Ser His Glu Thr Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Pro Gly Leu Gly Leu Gln Leu Ile Tyr Ile Ser Tyr Asp Val 
        355                 360                 365             


Asp Ser Asn Ser Glu Gly Asp Ile Pro Lys Gly Tyr Arg Val Ser Arg 
    370                 375                 380                 


Lys Lys Arg Glu His Phe Ser Leu Ile Leu Asp Ser Ala Lys Thr Asn 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Ser Thr Asn Thr Glu Val 
                405                 410                 415     


Phe Phe Gly Lys Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn 
            420                 425                 430         


Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile 
        435                 440                 445             


Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe 
    450                 455                 460                 


Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His 
465                 470                 475                 480 


Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser 
                485                 490                 495     


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn 
            500                 505                 510         


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu 
        515                 520                 525             


Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile 
    530                 535                 540                 


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
545                 550                 555                 560 


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
                565                 570                 575     


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met 
            580                 585                 590         


Ala Met Val Lys Arg Lys Asn Ser 
        595                 600 


<210>  61
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE 112-120 substituted alpha chain and beta chain with linker.

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa at 118 is Thr or Val.

<400>  61

Met Gly Pro Val Thr Cys Ser Val Leu Val Leu Leu Leu Met Leu Arg 
1               5                   10                  15      


Arg Ser Asn Gly Asp Gly Asp Ser Val Thr Gln Thr Glu Gly Leu Val 
            20                  25                  30          


Thr Leu Thr Glu Gly Leu Pro Val Met Leu Asn Cys Thr Tyr Gln Thr 
        35                  40                  45              


Ile Tyr Ser Asn Pro Phe Leu Phe Trp Tyr Val Gln His Leu Asn Glu 
    50                  55                  60                  


Ser Pro Arg Leu Leu Leu Lys Ser Phe Thr Asp Asn Lys Arg Thr Glu 
65                  70                  75                  80  


His Gln Gly Phe His Ala Thr Leu His Lys Ser Ser Ser Ser Phe His 
                85                  90                  95      


Leu Gln Lys Ser Ser Ala Gln Leu Ser Asp Ser Ala Leu Tyr Tyr Cys 
            100                 105                 110         


Ala Phe Asp Thr Asn Xaa Tyr Lys Val Ile Phe Gly Lys Gly Thr His 
        115                 120                 125             


Leu His Val Leu Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Thr Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala 
            260                 265                 270         


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Val Arg Leu Ile Ser 
    290                 295                 300                 


Ala Val Val Leu Cys Ser Leu Gly Thr Gly Leu Val Asp Met Lys Val 
305                 310                 315                 320 


Thr Gln Met Pro Arg Tyr Leu Ile Lys Arg Met Gly Glu Asn Val Leu 
                325                 330                 335     


Leu Glu Cys Gly Gln Asp Met Ser His Glu Thr Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Pro Gly Leu Gly Leu Gln Leu Ile Tyr Ile Ser Tyr Asp Val 
        355                 360                 365             


Asp Ser Asn Ser Glu Gly Asp Ile Pro Lys Gly Tyr Arg Val Ser Arg 
    370                 375                 380                 


Lys Lys Arg Glu His Phe Ser Leu Ile Leu Asp Ser Ala Lys Thr Asn 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Ser Thr Asn Thr Glu Val 
                405                 410                 415     


Phe Phe Gly Lys Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn 
            420                 425                 430         


Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile 
        435                 440                 445             


Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe 
    450                 455                 460                 


Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His 
465                 470                 475                 480 


Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser 
                485                 490                 495     


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn 
            500                 505                 510         


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu 
        515                 520                 525             


Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile 
    530                 535                 540                 


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
545                 550                 555                 560 


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
                565                 570                 575     


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met 
            580                 585                 590         


Ala Met Val Lys Arg Lys Asn Ser 
        595                 600 


<210>  62
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MAGE 271-279 alpha and beta chains with linker.

<400>  62

Met Val Leu Val Thr Ile Leu Leu Leu Ser Ala Phe Phe Ser Leu Arg 
1               5                   10                  15      


Gly Asn Ser Ala Gln Ser Val Asp Gln Pro Asp Ala His Val Thr Leu 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Ser Tyr Ser Tyr Ser Ala 
        35                  40                  45              


Ala Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln Ser Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Thr Val Val Lys Gly Thr Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Arg Lys Ser Asn Ser Ser Phe Asn Leu Lys 
                85                  90                  95      


Lys Ser Pro Ala His Trp Ser Asp Ser Ala Lys Tyr Phe Cys Ala Leu 
            100                 105                 110         


Glu Gly Pro Asp Thr Gly Asn Tyr Lys Tyr Val Phe Gly Ala Gly Thr 
        115                 120                 125             


Arg Leu Lys Val Ile Ala His Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
            260                 265                 270         


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Ile Gln Thr Leu 
    290                 295                 300                 


Cys Cys Val Ile Phe Tyr Val Leu Ile Ala Asn His Thr Asp Ala Gly 
305                 310                 315                 320 


Val Thr Gln Thr Pro Arg His Glu Val Ala Glu Lys Gly Gln Thr Ile 
                325                 330                 335     


Ile Leu Lys Cys Glu Pro Val Ser Gly His Asn Asp Leu Phe Trp Tyr 
            340                 345                 350         


Arg Gln Thr Lys Ile Gln Gly Leu Glu Leu Leu Ser Tyr Phe Arg Ser 
        355                 360                 365             


Lys Ser Leu Met Glu Asp Gly Gly Ala Phe Lys Asp Arg Phe Lys Ala 
    370                 375                 380                 


Glu Met Leu Asn Ser Ser Phe Ser Thr Leu Lys Ile Gln Pro Thr Glu 
385                 390                 395                 400 


Pro Arg Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Phe Gly Thr Ala 
                405                 410                 415     


Ser Ala Glu Thr Leu Tyr Phe Gly Ser Gly Thr Arg Leu Thr Val Leu 
            420                 425                 430         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        435                 440                 445             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    450                 455                 460                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
465                 470                 475                 480 


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
                485                 490                 495     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    530                 535                 540                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
        595                 600                 605 


<210>  63
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A3 271-279 peptide.

<400>  63

Phe Leu Trp Gly Pro Arg Ala Leu Val 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A1: 105-113.

<400>  64

Lys Val Ala Asp Leu Val Gly Phe Leu 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A4: 113-121.

<400>  65

Lys Val Asp Glu Leu Ala His Phe Leu 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-A8: 115-123.

<400>  66

Lys Val Ala Glu Leu Val Arg Phe Leu 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MAGE-C2: 144-152.

<400>  67

Lys Val Ala Glu Leu Val Glu Phe Leu 
1               5                   


<210>  68
<211>  13
<212>  PRT
<213>  Hepatitis B virus


<220>
<221>  misc_feature
<223>  HBVc: 128-140 helper peptide.

<400>  68

Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 
1               5                   10              


<210>  69
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Primer.

<400>  69
actggtacac agcaggttct gg                                                22


<210>  70
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Primer.

<400>  70
aaggagacct tgggtggagt c                                                 21


<210>  71
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Gly Pro Val Thr Cys Ser Val Leu Val Leu Leu Leu Met Leu Arg 
1               5                   10                  15      


Arg Ser Asn Gly Asp Gly Asp Ser Val Thr Gln Thr Glu Gly Leu Val 
            20                  25                  30          


Thr Leu Thr Glu Gly Leu Pro Val Met Leu Asn Cys Thr Tyr Gln Thr 
        35                  40                  45              


Ile Tyr Ser Asn Pro Phe Leu Phe Trp Tyr Val Gln His Leu Asn Glu 
    50                  55                  60                  


Ser Pro Arg Leu Leu Leu Lys Ser Phe Thr Asp Asn Lys Arg Thr Glu 
65                  70                  75                  80  


His Gln Gly Phe His Ala Thr Leu His Lys Ser Ser Ser Ser Phe His 
                85                  90                  95      


Leu Gln Lys Ser Ser Ala Gln Leu Ser Asp Ser Ala Leu Tyr Tyr Cys 
            100                 105                 110         


Ala Phe Asp Thr Asn Ala Tyr Lys Val Ile 
        115                 120         


<210>  72
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  72
atgggtcctg tcacctgctc agttcttgtg ctcctcctaa tgctcaggag gagcaatggc       60

gatggagact ccgtgaccca gacagaaggc ctggtcactc tcacagaagg gttgcctgtg      120

atgctgaact gcacctatca gactatttac tcaaatcctt tccttttctg gtatgtgcaa      180

catctcaatg aatcccctcg gctactcctg aagagcttca cagacaacaa gaggaccgag      240

caccaagggt tccacgccac tctccataag agcagcagct ccttccatct gcagaagtcc      300

tcagcgcagc tgtcagactc tgccctgtac tac                                   333


<210>  73
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Arg Val Arg Leu Ile Ser Ala Val Val Leu Cys Ser Leu Gly Thr 
1               5                   10                  15      


Gly Leu Val Asp Met Lys Val Thr Gln Met Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Arg Met Gly Glu Asn Val Leu Leu Glu Cys Gly Gln Asp Met Ser His 
        35                  40                  45              


Glu Thr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Gln Leu 
    50                  55                  60                  


Ile Tyr Ile Ser Tyr Asp Val Asp Ser Asn Ser Glu Gly Asp Ile Pro 
65                  70                  75                  80  


Lys Gly Tyr Arg Val Ser Arg Lys Lys Arg Glu His Phe Ser Leu Ile 
                85                  90                  95      


Leu Asp Ser Ala Lys Thr Asn Gln Thr Ser Val Tyr Phe Cys 
            100                 105                 110 


<210>  74
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  74
atgagagtta ggctcatctc tgctgtggtg ctgtgttccc taggaacagg ccttgtggac       60

atgaaagtaa cccagatgcc aagatacctg atcaaaagaa tgggagagaa tgttttgctg      120

gaatgtggac aggacatgag ccatgaaaca atgtactggt atcgacaaga ccctggtctg      180

gggctacagc tgatttatat ctcatacgat gttgatagta acagcgaagg agacatccct      240

aaaggataca gggtctcacg gaagaagcgg gagcatttct ccctgattct ggattctgct      300

aaaacaaacc agacatctgt gtacttc                                          327


<210>  75
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Val Leu Val Thr Ile Leu Leu Leu Ser Ala Phe Phe Ser Leu Arg 
1               5                   10                  15      


Gly Asn Ser Ala Gln Ser Val Asp Gln Pro Asp Ala His Val Thr Leu 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Ser Tyr Ser Tyr Ser Ala 
        35                  40                  45              


Ala Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln Ser Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Thr Val Val Lys Gly Thr Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Arg Lys Ser Asn Ser Ser Phe Asn Leu Lys 
                85                  90                  95      


Lys Ser Pro Ala His Trp Ser Asp Ser Ala Lys Tyr Phe 
            100                 105                 


<210>  76
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  76
atggtcctag tgaccattct gctgctcagc gcgttcttct cactgagagg aaacagtgcc       60

cagtccgtgg accagcctga tgctcatgtc acgctctctg aaggagcctc cctggagctc      120

agatgcagtt attcatacag tgcagcacct tacctcttct ggtacgtgca gtatcctggc      180

cagagcctcc agtttctcct caaatacatc acaggagaca ccgttgttaa aggcaccaag      240

ggctttgagg ccgagtttag gaagagtaac tcctctttca acctgaagaa atccccagcc      300

cattggagcg actcagccaa gtacttc                                          327


<210>  77
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Gly Ile Gln Thr Leu Cys Cys Val Ile Phe Tyr Val Leu Ile Ala 
1               5                   10                  15      


Asn His Thr Asp Ala Gly Val Thr Gln Thr Pro Arg His Glu Val Ala 
            20                  25                  30          


Glu Lys Gly Gln Thr Ile Ile Leu Lys Cys Glu Pro Val Ser Gly His 
        35                  40                  45              


Asn Asp Leu Phe Trp Tyr Arg Gln Thr Lys Ile Gln Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ser Tyr Phe Arg Ser Lys Ser Leu Met Glu Asp Gly Gly Ala Phe 
65                  70                  75                  80  


Lys Asp Arg Phe Lys Ala Glu Met Leu Asn Ser Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Thr Glu Pro Arg Asp Ser Ala Val Tyr Leu 
            100                 105                 110 


<210>  78
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  78
atgggcatcc agaccctctg ttgtgtgatc ttttatgttc tgatagcaaa tcacacagat       60

gctggagtta cccagacacc cagacatgag gtggcagaga aaggacaaac aataatcctg      120

aagtgtgagc cagtttcagg ccacaatgac cttttctggt acagacagac caagatacag      180

ggactagagt tgctgagcta cttccgcagc aagtctctta tggaagatgg tggggctttc      240

aaggatcgat tcaaagctga gatgctaaat tcatccttct ccactctgaa gattcaacct      300

acagaaccca gggactcagc tgtgtatctg                                       330


<210>  79
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  MAGE-A3 112-120 variable region alpha chain amino acid sequence 
       substituted.

<220>
<221>  MISC_FEATURE
<222>  (118)..(118)
<223>  Xaa at 118 is Thr or Val.

<400>  79

Met Gly Pro Val Thr Cys Ser Val Leu Val Leu Leu Leu Met Leu Arg 
1               5                   10                  15      


Arg Ser Asn Gly Asp Gly Asp Ser Val Thr Gln Thr Glu Gly Leu Val 
            20                  25                  30          


Thr Leu Thr Glu Gly Leu Pro Val Met Leu Asn Cys Thr Tyr Gln Thr 
        35                  40                  45              


Ile Tyr Ser Asn Pro Phe Leu Phe Trp Tyr Val Gln His Leu Asn Glu 
    50                  55                  60                  


Ser Pro Arg Leu Leu Leu Lys Ser Phe Thr Asp Asn Lys Arg Thr Glu 
65                  70                  75                  80  


His Gln Gly Phe His Ala Thr Leu His Lys Ser Ser Ser Ser Phe His 
                85                  90                  95      


Leu Gln Lys Ser Ser Ala Gln Leu Ser Asp Ser Ala Leu Tyr Tyr Cys 
            100                 105                 110         


Ala Phe Asp Thr Asn Xaa Tyr Lys Val Ile 
        115                 120         


