                         SEQUENCE LISTING

<110>  Merial
 
<120>  Her2 DNA Vaccine as Adjunct Treatment for Cancers in Companion 
       Animals

<130>  MER 10-155

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  4727
<212>  DNA
<213>  Rattus norvegicus

<400>  1
gcgccccttc ccaggcggcc ccttccggcg ccgcgcctgt gcctgccctc gccgcgcccc       60

gcgcccgcag cctggtccag cctgagccat ggggccggag ccgcaatgat catcatggag      120

ctggcggcct ggtgccgctg ggggttcctc ctcgccctcc tgccccccgg aatcgcgggc      180

acccaagtgt gtaccggcac agacatgaag ttgcggctcc ctgccagtcc tgagacccac      240

ctggacatgc tccgccacct gtaccagggc tgtcaggtag tgcagggcaa cttggagctt      300

acctacgtgc ctgccaatgc cagcctctca ttcctgcagg acatccagga agttcagggt      360

tacatgctca tcgctcacaa ccaggtgaag cgcgtcccac tgcaaaggct gcgcatcgtg      420

agagggaccc agctctttga ggacaagtat gccctggctg tgctagacaa ccgagatcct      480

caggacaatg tcgccgcctc caccccaggc agaaccccag aggggctgcg ggagctgcag      540

cttcgaagtc tcacagagat cctgaaggga ggagttttga tccgtgggaa ccctcagctc      600

tgctaccagg acatggtttt gtggaaggac gtcttccgca agaataacca actggctcct      660

gtcgatatag acaccaatcg ttcccgggcc tgtccacctt gtgcccccgc ctgcaaagac      720

aatcactgtt ggggtgagag tccggaagac tgtcagatct tgactggcac catctgtacc      780

agtggttgtg cccggtgcaa gggccggctg cccactgact gctgccatga gcagtgtgcc      840

gcaggctgca cgggccccaa gcattctgac tgcctggcct gcctccactt caatcatagt      900

ggtatctgtg agctgcactg cccagccctc gtcacctaca acacagacac ctttgagtcc      960

atgcacaacc ctgagggtcg ctacaccttt ggtgccagct gcgtgaccac ctgcccctac     1020

aactacctgt ctacggaagt gggatcctgc actctggtgt gtcccccgaa taaccaagag     1080

gtcacagctg aggacggaac acagcgttgt gagaaatgca gcaagccctg tgctcgagtg     1140

tgctatggtc tgggcatgga gcaccttcga ggggcgaggg ccatcaccag tgacaatgtc     1200

caggagtttg atggctgcaa gaagatcttt gggagcctgg catttttgcc ggagagcttt     1260

gatggggacc cctcctccgg cattgctccg ctgaggcctg agcagctcca agtgttcgaa     1320

accctggagg agatcacagg ttacctgtac atctcagcat ggccagacag tctccgtgac     1380

ctcagtgtct tccagaacct tcgaatcatt cggggacgga ttctccacga tggcgcgtac     1440

tcattgacac tgcaaggcct ggggatccac tcgctggggc tgcgctcact gcgggagctg     1500

ggcagtggat tggctctgat tcaccgcaac gcccatctct gctttgtaca cactgtacct     1560

tgggaccagc tcttccggaa cccacatcag gccctgctcc acagtgggaa ccggccggaa     1620

gaggattgtg gtctcgaggg cttggtctgt aactcactgt gtgcccacgg gcactgctgg     1680

gggccagggc ccacccagtg tgtcaactgc agtcatttcc ttcggggcca ggagtgtgtg     1740

gaggagtgcc gagtatggaa ggggctcccc cgggagtatg tgagtgacaa gcgctgtctg     1800

ccgtgtcacc ccgagtgtca gcctcaaaac agctcagaga cctgctttgg atcggaggct     1860

gatcagtgtg cagcctgcgc ccactacaag gactcgtcct cctgtgtggc tcgctgcccc     1920

agtggtgtga aaccggacct ctcctacatg cccatctgga agtacccgga tgaggagggc     1980

atatgccagc cgtgccccat caactgcacc cactcctgtg tggatctgga tgaacgaggc     2040

tgcccagcag agcagagagc cagcccggtg acattcatca ttgcaactgt agtgggcgtc     2100

ctgctgttcc tgatcttagt ggtggtcgtt ggaatcctaa tcaaacgaag gagacagaag     2160

atccggaagt atacgatgcg taggctgctg caggaaactg agttagtgga gccgctgacg     2220

cccagcggag caatgcccaa ccaggctcag atgcggatcc taaaagagac ggagctaagg     2280

aaggtgaagg tgcttggatc aggagctttt ggcactgtct acaagggcat ctggatccca     2340

gatggggaga atgtgaaaat ccccgtggct atcaaggtgt tgagagaaaa cacatctcct     2400

aaagccaaca aagaaattct agatgaagcg tatgtgatgg ctggtgtggg ttctccgtat     2460

gtgtcccgcc tcctgggcat ctgcctgaca tccacagtac agctggtgac acagcttatg     2520

ccctacggct gccttctgga ccatgtccga gaacaccgag gtcgcctagg ctcccaggac     2580

ctgctcaact ggtgtgttca gattgccaag gggatgagct acctggagga cgtgcggctt     2640

gtacacaggg acctggctgc ccggaatgtg ctagtcaaga gtcccaacca cgtcaagatt     2700

acagatttcg ggctggctcg gctgctggac attgatgaga cagagtacca tgcagatggg     2760

ggcaaggtgc ccatcaaatg gatggcattg gaatctattc tcagacgccg gttcacccat     2820

cagagtgatg tgtggagcta tggagtgact gtgtgggagc tgatgacttt tggggccaaa     2880

ccttacgatg gaatcccagc ccgggagatc cctgatttgc tggagaaggg agaacgccta     2940

cctcagcctc caatctgcac cattgatgtc tacatgatta tggtcaaatg ttggatgatt     3000

gactctgaat gtcgcccgag attccgggag ttggtgtcag aattttcacg tatggcgagg     3060

gacccccagc gttttgtggt catccagaac gaggacttgg gcccatccag ccccatggac     3120

agtaccttct accgttcact gctggaagat gatgacatgg gtgacctggt agacgctgaa     3180

gagtatctgg tgccccagca gggattcttc tccccggacc ctaccccagg cactgggagc     3240

acagcccata gaaggcaccg cagctcgtcc accaggagtg gaggtggtga gctgacactg     3300

ggcctggagc cctcggaaga agggcccccc agatctccac tggctccctc ggaaggggct     3360

ggctccgatg tgtttgatgg tgacctggca atgggggtaa ccaaagggct gcagagcctc     3420

tctccacatg acctcagccc tctacagcgg tacagcgagg accccacatt acctctgccc     3480

cccgagactg atggctatgt tgctcccctg gcctgcagcc cccagcccga gtatgtgaac     3540

caatcagagg ttcagcctca gcctccttta accccagagg gtcctctgcc tcctgtccgg     3600

cctgctggtg ctactctaga aagacccaag actctctctc ctgggaagaa tggggttgtc     3660

aaagacgttt ttgccttcgg gggtgctgtg gagaaccctg aatacttagt accgagagaa     3720

ggcactgcct ctccgcccca cccttctcct gccttcagcc cagcctttga caacctctat     3780

tactgggacc agaactcatc ggagcagggg cctccaccaa gtaactttga agggaccccc     3840

actgcagaga accctgagta cctaggcctg gatgtacctg tatgagacgt gtgcagacgt     3900

cctgtgcttt cagagtgggg aaggcctgac ttgtggtctc catcgccaca aagcagggag     3960

agggtcctct ggccacatta catccagggc agacggctct accaggaacc tgccccgagg     4020

aacctttcct tgctgcttga atcctgagtg gttaagaggg ccctgcctgg ctgggagaga     4080

tggcactgga cggcctctgg attacagacc ctgccctgac agactatagg gtccagtggg     4140

tatcatggcc atggcttctt gcctggcctg gctctcttgg ttctgaggac tgaggaaagc     4200

tcagcctaga agggaagagg tctggaggga acatcctggg aacaggacaa gccactagga     4260

ctgagacaca tgcatcccaa cagggggctg cactttcatc cagaccagtc tttgtacaga     4320

gtgtattttg ttctgttttt acttttgctt ttttttttaa aaaaagatga aataaggaca     4380

cggagggaga gtggatgtta gggaatggtg tccctctttc ttcatttaca atgagatttg     4440

taaaatagct gggccccagc ctatgcctgg gagtggtccc aggctagacc ttactgctca     4500

cctgacacac agctcctcct tgagttgagt gtgtagaagt tttccaaaag tttgagatgg     4560

tttggctttg gggttgaggg actgggaagt taggatcctt tctgagggcc ctttggcaac     4620

aggatcattc ttcattggac gcactcattc caaggctacc cctagaatga agtccttccc     4680

tcccagtggg agagtggccc ttgaaaggag cactgtcaca tgactca                   4727


<210>  2
<211>  1259
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Ile Ile Met Glu Leu Ala Ala Trp Cys Arg Trp Gly Phe Leu Leu 
1               5                   10                  15      


Ala Leu Leu Pro Pro Gly Ile Ala Gly Thr Gln Val Cys Thr Gly Thr 
            20                  25                  30          


Asp Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met 
        35                  40                  45              


Leu Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu 
    50                  55                  60                  


Leu Thr Tyr Val Pro Ala Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile 
65                  70                  75                  80  


Gln Glu Val Gln Gly Tyr Met Leu Ile Ala His Asn Gln Val Lys Arg 
                85                  90                  95      


Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu 
            100                 105                 110         


Asp Lys Tyr Ala Leu Ala Val Leu Asp Asn Arg Asp Pro Gln Asp Asn 
        115                 120                 125             


Val Ala Ala Ser Thr Pro Gly Arg Thr Pro Glu Gly Leu Arg Glu Leu 
    130                 135                 140                 


Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Arg 
145                 150                 155                 160 


Gly Asn Pro Gln Leu Cys Tyr Gln Asp Met Val Leu Trp Lys Asp Val 
                165                 170                 175     


Phe Arg Lys Asn Asn Gln Leu Ala Pro Val Asp Ile Asp Thr Asn Arg 
            180                 185                 190         


Ser Arg Ala Cys Pro Pro Cys Ala Pro Ala Cys Lys Asp Asn His Cys 
        195                 200                 205             


Trp Gly Glu Ser Pro Glu Asp Cys Gln Ile Leu Thr Gly Thr Ile Cys 
    210                 215                 220                 


Thr Ser Gly Cys Ala Arg Cys Lys Gly Arg Leu Pro Thr Asp Cys Cys 
225                 230                 235                 240 


His Glu Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys 
                245                 250                 255     


Leu Ala Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys 
            260                 265                 270         


Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met His Asn 
        275                 280                 285             


Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Thr Cys Pro 
    290                 295                 300                 


Tyr Asn Tyr Leu Ser Thr Glu Val Gly Ser Cys Thr Leu Val Cys Pro 
305                 310                 315                 320 


Pro Asn Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu 
                325                 330                 335     


Lys Cys Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu 
            340                 345                 350         


His Leu Arg Gly Ala Arg Ala Ile Thr Ser Asp Asn Val Gln Glu Phe 
        355                 360                 365             


Asp Gly Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser 
    370                 375                 380                 


Phe Asp Gly Asp Pro Ser Ser Gly Ile Ala Pro Leu Arg Pro Glu Gln 
385                 390                 395                 400 


Leu Gln Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile 
                405                 410                 415     


Ser Ala Trp Pro Asp Ser Leu Arg Asp Leu Ser Val Phe Gln Asn Leu 
            420                 425                 430         


Arg Ile Ile Arg Gly Arg Ile Leu His Asp Gly Ala Tyr Ser Leu Thr 
        435                 440                 445             


Leu Gln Gly Leu Gly Ile His Ser Leu Gly Leu Arg Ser Leu Arg Glu 
    450                 455                 460                 


Leu Gly Ser Gly Leu Ala Leu Ile His Arg Asn Ala His Leu Cys Phe 
465                 470                 475                 480 


Val His Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala 
                485                 490                 495     


Leu Leu His Ser Gly Asn Arg Pro Glu Glu Asp Cys Gly Leu Glu Gly 
            500                 505                 510         


Leu Val Cys Asn Ser Leu Cys Ala His Gly His Cys Trp Gly Pro Gly 
        515                 520                 525             


Pro Thr Gln Cys Val Asn Cys Ser His Phe Leu Arg Gly Gln Glu Cys 
    530                 535                 540                 


Val Glu Glu Cys Arg Val Trp Lys Gly Leu Pro Arg Glu Tyr Val Ser 
545                 550                 555                 560 


Asp Lys Arg Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Ser 
                565                 570                 575     


Ser Glu Thr Cys Phe Gly Ser Glu Ala Asp Gln Cys Ala Ala Cys Ala 
            580                 585                 590         


His Tyr Lys Asp Ser Ser Ser Cys Val Ala Arg Cys Pro Ser Gly Val 
        595                 600                 605             


Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Tyr Pro Asp Glu Glu 
    610                 615                 620                 


Gly Ile Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp 
625                 630                 635                 640 


Leu Asp Glu Arg Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Val Thr 
                645                 650                 655     


Phe Ile Ile Ala Thr Val Val Gly Val Leu Leu Phe Leu Ile Leu Val 
            660                 665                 670         


Val Val Val Gly Ile Leu Ile Lys Arg Arg Arg Gln Lys Ile Arg Lys 
        675                 680                 685             


Tyr Thr Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu 
    690                 695                 700                 


Thr Pro Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys 
705                 710                 715                 720 


Glu Thr Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly 
                725                 730                 735     


Thr Val Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile 
            740                 745                 750         


Pro Val Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn 
        755                 760                 765             


Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro 
    770                 775                 780                 


Tyr Val Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu 
785                 790                 795                 800 


Val Thr Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu 
                805                 810                 815     


His Arg Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Val Gln 
            820                 825                 830         


Ile Ala Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg 
        835                 840                 845             


Asp Leu Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys 
    850                 855                 860                 


Ile Thr Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu 
865                 870                 875                 880 


Tyr His Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu 
                885                 890                 895     


Ser Ile Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr 
            900                 905                 910         


Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp 
        915                 920                 925             


Gly Ile Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg 
    930                 935                 940                 


Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val 
945                 950                 955                 960 


Lys Cys Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu 
                965                 970                 975     


Val Ser Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val 
            980                 985                 990         


Ile Gln Asn Glu Asp Leu Gly Pro  Ser Ser Pro Met Asp  Ser Thr Phe 
        995                 1000                 1005             


Tyr Arg  Ser Leu Leu Glu Asp  Asp Asp Met Gly Asp  Leu Val Asp 
    1010                 1015                 1020             


Ala Glu  Glu Tyr Leu Val Pro  Gln Gln Gly Phe Phe  Ser Pro Asp 
    1025                 1030                 1035             


Pro Thr  Pro Gly Thr Gly Ser  Thr Ala His Arg Arg  His Arg Ser 
    1040                 1045                 1050             


Ser Ser  Thr Arg Ser Gly Gly  Gly Glu Leu Thr Leu  Gly Leu Glu 
    1055                 1060                 1065             


Pro Ser  Glu Glu Gly Pro Pro  Arg Ser Pro Leu Ala  Pro Ser Glu 
    1070                 1075                 1080             


Gly Ala  Gly Ser Asp Val Phe  Asp Gly Asp Leu Ala  Met Gly Val 
    1085                 1090                 1095             


Thr Lys  Gly Leu Gln Ser Leu  Ser Pro His Asp Leu  Ser Pro Leu 
    1100                 1105                 1110             


Gln Arg  Tyr Ser Glu Asp Pro  Thr Leu Pro Leu Pro  Pro Glu Thr 
    1115                 1120                 1125             


Asp Gly  Tyr Val Ala Pro Leu  Ala Cys Ser Pro Gln  Pro Glu Tyr 
    1130                 1135                 1140             


Val Asn  Gln Ser Glu Val Gln  Pro Gln Pro Pro Leu  Thr Pro Glu 
    1145                 1150                 1155             


Gly Pro  Leu Pro Pro Val Arg  Pro Ala Gly Ala Thr  Leu Glu Arg 
    1160                 1165                 1170             


Pro Lys  Thr Leu Ser Pro Gly  Lys Asn Gly Val Val  Lys Asp Val 
    1175                 1180                 1185             


Phe Ala  Phe Gly Gly Ala Val  Glu Asn Pro Glu Tyr  Leu Val Pro 
    1190                 1195                 1200             


Arg Glu  Gly Thr Ala Ser Pro  Pro His Pro Ser Pro  Ala Phe Ser 
    1205                 1210                 1215             


Pro Ala  Phe Asp Asn Leu Tyr  Tyr Trp Asp Gln Asn  Ser Ser Glu 
    1220                 1225                 1230             


Gln Gly  Pro Pro Pro Ser Asn  Phe Glu Gly Thr Pro  Thr Ala Glu 
    1235                 1240                 1245             


Asn Pro  Glu Tyr Leu Gly Leu  Asp Val Pro Val 
    1250                 1255                 


<210>  3
<211>  3768
<212>  DNA
<213>  Mus musculus

<400>  3
atggagctgg cggcctggtg ccgttggggg ttcctcctcg ccctcctgtc ccccggagcc       60

gcgggtaccc aagtgtgtac cggtaccgac atgaagttgc gactccctgc cagtcctgag      120

acccacctgg acatgcttcg ccacctctac cagggctgtc aggtggtgca gggcaatttg      180

gagcttacct acctgcccgc caatgccagc ctctcattcc tgcaggacat ccaggaagtc      240

cagggataca tgctcatcgc tcacaaccga gtgaaacacg tcccactgca gaggttgcgc      300

atcgtgagag ggactcagct ctttgaggac aagtatgccc tggctgtgct agacaaccga      360

gaccctttgg acaacgtcac caccgccgcc ccaggcagaa ccccagaagg gctgcgggag      420

ctgcagcttc gaagtctcac agagatcttg aagggaggag ttttgatccg tgggaaccct      480

cagctctgct accaggacat ggttttgtgg aaggatgtcc tccgtaagaa taaccagctg      540

gctcctgtcg acatggacac caatcgttcc cgggcctgtc caccttgtgc cccaacctgc      600

aaagacaatc actgttgggg tgagagtcct gaagactgtc agatcttgac tggcaccatc      660

tgtactagtg gctgtgcccg gtgcaagggc cggctgccca ctgactgttg ccatgagcag      720

tgtgctgcag gctgcacggg tcccaagcat tctgactgcc tggcctgcct ccacttcaat      780

catagtggta tctgtgagct gcactgcccg gccctcatca cctacaacac agacaccttc      840

gagtccatgc tcaaccctga gggtcgctac acctttggtg ccagctgtgt gaccacctgc      900

ccctacaact acctctccac ggaagtggga tcctgcactc tggtctgtcc cccgaacaac      960

caagaggtca cagctgagga cggaacacag cggtgtgaga aatgcagcaa gccctgtgct     1020

ggagtatgct atggtctggg catggagcac ctccgagggg cgagggccat caccagtgac     1080

aatatccagg agtttgctgg ctgcaagaag atctttggga gcctggcatt tttgccggag     1140

agctttgatg ggaacccctc ctccggcgtt gccccactga agccagagca tctccaagtg     1200

ttcgaaaccc tggaggagat cacaggttac ctatacattt cagcatggcc agagagcttc     1260

caagacctca gtgtcttcca gaaccttcgg gtcattcggg gacggattct ccatgatggt     1320

gcttactcat tgacgttgca aggcctgggg attcactcac tggggctacg ctcactgcgg     1380

gagctgggca gtggattggc tctcattcac cgcaacaccc atctctgctt tgtaaacact     1440

gtaccttggg accagctctt ccggaacccg caccaggccc tactccacag tgggaaccgg     1500

ccagaagagg catgtggtct tgagggcttg gtctgtaact cactgtgtgc ccgtgggcac     1560

tgctgggggc cagggcccac ccagtgtgtc aactgcagtc agttcctccg gggccaggag     1620

tgtgtggagg agtgccgagt atggaagggg ctccccaggg agtatgtgag gggcaagcac     1680

tgtctgccat gccaccccga gtgtcagcct caaaacagct cggagacctg ctatggatcg     1740

gaggctgacc agtgtgaggc ttgtgcccac tacaaggact catcttcctg tgtggctcgc     1800

tgccccagtg gtgtgaagcc agacctctcc tacatgccta tctggaagta cccggatgag     1860

gagggcatat gtcagccatg ccccatcaac tgcacccact catgtgtgga cctggacgaa     1920

cgaggctgcc cagcagagca gagagccagc ccagtgacat tcatcattgc aactgtggtg     1980

ggcgtcctgt tgttcctgat catagtggtg gtcattggaa tcctaatcaa acgaaggcga     2040

cagaagatcc ggaagtatac catgcgtagg ctgctgcagg agaccgagct ggtggagccg     2100

ctgacgccca gtggagctgt gcccaaccag gctcagatgc ggatcctaaa ggagacagag     2160

ctaaggaagc tgaaggtgct tgggtcagga gccttcggca ctgtctacaa gggcatctgg     2220

atcccagatg gggagaacgt gaaaatcccc gtggccatca aggtgttgag ggaaaacaca     2280

tctcctaaag ctaacaaaga aatcctagat gaagcgtacg tcatggctgg tgtgggttct     2340

ccatatgtgt cccgcctcct gggcatctgc ctgacatcca cagtgcagct ggtgacacag     2400

cttatgccct atggctgcct tctggaccat gtccgagaac accgaggtcg cttaggctcc     2460

caggacctgc tcaactggtg tgttcagatt gccaagggga tgagctacct ggaggaagtt     2520

cggcttgttc acagggacct agctgcccga aacgtgctag tcaagagtcc caaccacgtc     2580

aagattaccg acttcgggct ggcacggctg ctggacattg atgagactga ataccatgca     2640

gatgggggca aggtgcccat caagtggatg gcattggaat ctattctcag acgccggttc     2700

acccatcaga gtgatgtgtg gagctatggt gtgactgtgt gggagctgat gacctttggg     2760

gccaaacctt acgatgggat cccagctcgg gagatccctg atttgctgga gaagggagaa     2820

cgcctacctc agcctccaat ctgcaccatc gacgtctaca tgatcatggt caaatgttgg     2880

atgattgact ccgaatgtcg cccgagattc cgggagttgg tatcagaatt ctcccgtatg     2940

gcaagggacc cccagcgctt tgtggtcatc cagaacgagg acttaggccc ctccagcccc     3000

atggacagca ccttctaccg ttcactgctg gaggatgatg acatggggga gctggtcgat     3060

gctgaagagt acctggtacc ccagcaggga ttcttctccc cagaccctgc cctaggtact     3120

gggagcacag cccaccgcag acaccgcagc tcgtcggcca ggagtggcgg tggtgagctg     3180

acactgggcc tggagccctc ggaagaagag ccccccagat ctccactggc tccctccgaa     3240

ggggctggct ccgatgtgtt tgatggtgac ctggcagtgg gggtaaccaa aggactgcag     3300

agcctctctc cacatgacct cagccctcta cagcggtaca gtgaggatcc cacattacct     3360

ctgccccccg agactgatgg ctacgttgct cccctggcct gcagccccca gcccgagtat     3420

gtgaaccagc cagaggttcg gcctcagtct cccttgaccc cagagggtcc tccgcctccc     3480

atccgacctg ctggtgctac tctagaaaga cccaagactc tctctcctgg gaaaaatggg     3540

gttgtcaaag acgtttttgc ctttgggggt gctgtggaga accctgaata cttagcaccc     3600

agagcaggca ctgcctctca gccccaccct tctcctgcct tcagcccagc ctttgacaac     3660

ctctattact gggaccagaa ctcatcggag cagggtcctc caccaagtac ctttgaaggg     3720

acccccactg cagagaaccc tgagtaccta ggcctggatg tgccagta                  3768


<210>  4
<211>  3765
<212>  DNA
<213>  homo sapiens

<400>  4
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag     1920

ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc ggtggttggc     1980

attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggcagcag     2040

aagatccgga agtacacgat gcggagactg ctgcaggaaa cggagctggt ggagccgctg     2100

acacctagcg gagcgatgcc caaccaggcg cagatgcgga tcctgaaaga gacggagctg     2160

aggaaggtga aggtgcttgg atctggcgct tttggcacag tctacaaggg catctggatc     2220

cctgatgggg agaatgtgaa aattccagtg gccatcaaag tgttgaggga aaacacatcc     2280

cccaaagcca acaaagaaat cttagacgaa gcatacgtga tggctggtgt gggctcccca     2340

tatgtctccc gccttctggg catctgcctg acatccacgg tgcagctggt gacacagctt     2400

atgccctatg gctgcctctt agaccatgtc cgggaaaacc gcggacgcct gggctcccag     2460

gacctgctga actggtgtat gcagattgcc aaggggatga gctacctgga ggatgtgcgg     2520

ctcgtacaca gggacttggc cgctcggaac gtgctggtca agagtcccaa ccatgtcaaa     2580

attacagact tcgggctggc tcggctgctg gacattgacg agacagagta ccatgcagat     2640

gggggcaagg tgcccatcaa gtggatggcg ctggagtcca ttctccgccg gcggttcacc     2700

caccagagtg atgtgtggag ttatggtgtg actgtgtggg agctgatgac ttttggggcc     2760

aaaccttacg atgggatccc agcccgggag atccctgacc tgctggaaaa gggggagcgg     2820

ctgccccagc cccccatctg caccattgat gtctacatga tcatggtcaa atgttggatg     2880

attgactctg aatgtcggcc aagattccgg gagttggtgt ctgaattctc ccgcatggcc     2940

agggaccccc agcgctttgt ggtcatccag aatgaggact tgggcccagc cagtcccttg     3000

gacagcacct tctaccgctc actgctggag gacgatgaca tgggggacct ggtggatgct     3060

gaggagtatc tggtacccca gcagggcttc ttctgtccag accctgcccc gggcgctggg     3120

ggcatggtcc accacaggca ccgcagctca tctaccagga gtggcggtgg ggacctgaca     3180

ctagggctgg agccctctga agaggaggcc cccaggtctc cactggcacc ctccgaaggg     3240

gctggctccg atgtatttga tggtgacctg ggaatggggg cagccaaggg gctgcaaagc     3300

ctccccacac atgaccccag ccctctacag cggtacagtg aggaccccac agtacccctg     3360

ccctctgaga ctgatggcta cgttgccccc ctgacctgca gcccccagcc tgaatatgtg     3420

aaccagccag atgttcggcc ccagccccct tcgccccgag agggccctct gcctgctgcc     3480

cgacctgctg gtgccactct ggaaaggccc aagactctct ccccagggaa gaatggggtc     3540

gtcaaagacg tttttgcctt tgggggtgcc gtggagaacc ccgagtactt gacaccccag     3600

ggaggagctg cccctcagcc ccaccctcct cctgccttca gcccagcctt cgacaacctc     3660

tattactggg accaggaccc accagagcgg ggggctccac ccagcacctt caaagggaca     3720

cctacggcag agaacccaga gtacctgggt ctggacgtgc cagtg                     3765


