                         SEQUENCE LISTING

<110>  Universit Bordeaux Segalen
       INSERM
       Institut Bergoni
       Institut Curie
 
<120>  Signatures of clinical outcome in gastrointestinal stromal tumors
        and method of treatment of gastrointestinal stromal tumors

<130>  BIP208465PC00

<150>  EP10013806
<151>  2010-10-20

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  2
<211>  2339
<212>  DNA
<213>  cDNA corresponding to mRNA

<400>  2
acaaggcagc ctcgctcgag cgcaggccaa tcggctttct agctagaggg tttaactcct       60

atttaaaaag aagaaccttt gaattctaac ggctgagctc ttggaagact tgggtccttg      120

ggtcgcaggt gggagccgac gggtgggtag accgtggggg atatctcagt ggcggacgag      180

gacggcgggg acaaggggcg gctggtcgga gtggcggagc gtcaagtccc ctgtcggttc      240

ctccgtccct gagtgtcctt ggcgctgcct tgtgcccgcc cagcgccttt gcatccgctc      300

ctgggcaccg aggcgccctg taggatactg cttgttactt attacagcta gaggcatcat      360

ggaccgatct aaagaaaact gcatttcagg acctgttaag gctacagctc cagttggagg      420

tccaaaacgt gttctcgtga ctcagcaatt tccttgtcag aatccattac ctgtaaatag      480

tggccaggct cagcgggtct tgtgtccttc aaattcttcc cagcgcattc ctttgcaagc      540

acaaaagctt gtctccagtc acaagccggt tcagaatcag aagcagaagc aattgcaggc      600

aaccagtgta cctcatcctg tctccaggcc actgaataac acccaaaaga gcaagcagcc      660

cctgccatcg gcacctgaaa ataatcctga ggaggaactg gcatcaaaac agaaaaatga      720

agaatcaaaa aagaggcagt gggctttgga agactttgaa attggtcgcc ctctgggtaa      780

aggaaagttt ggtaatgttt atttggcaag agaaaagcaa agcaagttta ttctggctct      840

taaagtgtta tttaaagctc agctggagaa agccggagtg gagcatcagc tcagaagaga      900

agtagaaata cagtcccacc ttcggcatcc taatattctt agactgtatg gttatttcca      960

tgatgctacc agagtctacc taattctgga atatgcacca cttggaacag tttatagaga     1020

acttcagaaa ctttcaaagt ttgatgagca gagaactgct acttatataa cagaattggc     1080

aaatgccctg tcttactgtc attcgaagag agttattcat agagacatta agccagagaa     1140

cttacttctt ggatcagctg gagagcttaa aattgcagat tttgggtggt cagtacatgc     1200

tccatcttcc aggaggacca ctctctgtgg caccctggac tacctgcccc ctgaaatgat     1260

tgaaggtcgg atgcatgatg agaaggtgga tctctggagc cttggagttc tttgctatga     1320

atttttagtt gggaagcctc cttttgaggc aaacacatac caagagacct acaaaagaat     1380

atcacgggtt gaattcacat tccctgactt tgtaacagag ggagccaggg acctcatttc     1440

aagactgttg aagcataatc ccagccagag gccaatgctc agagaagtac ttgaacaccc     1500

ctggatcaca gcaaattcat caaaaccatc aaattgccaa aacaaagaat cagctagcaa     1560

acagtcttag gaatcgtgca gggggagaaa tccttgagcc agggctgcca tataacctga     1620

caggaacatg ctactgaagt ttattttacc attgactgct gccctcaatc tagaacgcta     1680

cacaagaaat atttgtttta ctcagcaggt gtgccttaac ctccctattc agaaagctcc     1740

acatcaataa acatgacact ctgaagtgaa agtagccacg agaattgtgc tacttatact     1800

ggttcataat ctggaggcaa ggttcgactg cagccgcccc gtcagcctgt gctaggcatg     1860

gtgtcttcac aggaggcaaa tccagagcct ggctgtgggg aaagtgacca ctctgccctg     1920

accccgatca gttaaggagc tgtgcaataa ccttcctagt acctgagtga gtgtgtaact     1980

tattgggttg gcgaagcctg gtaaagctgt tggaatgagt atgtgattct ttttaagtat     2040

gaaaataaag atatatgtac agacttgtat tttttctctg gtggcattcc tttaggaatg     2100

ctgtgtgtct gtccggcacc ccggtaggcc tgattgggtt tctagtcctc cttaaccact     2160

tatctcccat atgagagtgt gaaaaatagg aacacgtgct ctacctccat ttagggattt     2220

gcttgggata cagaagaggc catgtgtctc agagctgtta agggcttatt tttttaaaac     2280

attggagtca tagcatgtgt gtaaacttta aatatgcaaa taaataagta tctatgtct      2339


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  3
tggatctgct ggttgtccaa                                                   20


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  4
ccagtcttga tcagctgcac at                                                22


<210>  5
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  5
aggtgtttac tgccccacta ttatctggtt caga                                   34


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  6
tcatgtcaga gagagagctt gg                                                22


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  7
cgtgcactcc tgttctgacc                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  8
aatggttcac ctcgaacacc                                                   20


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  9
ctcggtaata caagcgaact cc                                                22


<210>  10
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  artificial sequence

<400>  10
cctccacaca ctccagttag g                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  11
tgatcagttg gtccttctcg                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  12
gcatggctct cagattcacc                                                   20


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  13
tcgaggaatg tgaggtattg g                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  14
tcttcctcat gctgttcagg                                                   20


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  15
tgtacacagt gtccaccaag g                                                 21


