                         SEQUENCE LISTING

<110>  Duke University
       Zhang, Zhiquan
       MacKensen, G. Burhard
       Ma, Qing
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARDIAC 
       SURGERY-ASSOCIATED ACUTE KIDNEY INJURY WITH ANNEXIN A1 PEPTIDE

<130>  5405-442WO

<150>  US 61/393,402
<151>  2010-10-15

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1399
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (75)..(1115)

<400>  1
agtgtgaaat cttcagagaa gaatttctct ttagttcttt gcaagaaggt agagataaag       60

acactttttc aaaa atg gca atg gta tca gaa ttc ctc aag cag gcc tgg        110
                Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp           
                1               5                   10                    

ttt att gaa aat gaa gag cag gaa tat gtt caa act gtg aag tca tcc        158
Phe Ile Glu Asn Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser           
        15                  20                  25                        

aaa ggt ggt ccc gga tca gcg gtg agc ccc tat cct acc ttc aat cca        206
Lys Gly Gly Pro Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro           
    30                  35                  40                            

tcc tcg gat gtc gct gcc ttg cat aag gcc ata atg gtt aaa ggt gtg        254
Ser Ser Asp Val Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val           
45                  50                  55                  60            

gat gaa gca acc atc att gac att cta act aag cga aac aat gca cag        302
Asp Glu Ala Thr Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln           
                65                  70                  75                

cgt caa cag atc aaa gca gca tat ctc cag gaa aca gga aag ccc ctg        350
Arg Gln Gln Ile Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu           
            80                  85                  90                    

gat gaa aca ctt aag aaa gcc ctt aca ggt cac ctt gag gag gtt gtt        398
Asp Glu Thr Leu Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val           
        95                  100                 105                       

tta gct ctg cta aaa act cca gcg caa ttt gat gct gat gaa ctt cgt        446
Leu Ala Leu Leu Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg           
    110                 115                 120                           

gct gcc atg aag ggc ctt gga act gat gaa gat act cta att gag att        494
Ala Ala Met Lys Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile           
125                 130                 135                 140           

ttg gca tca aga act aac aaa gaa atc aga gac att aac agg gtc tac        542
Leu Ala Ser Arg Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr           
                145                 150                 155               

aga gag gaa ctg aag aga gat ctg gcc aaa gac ata acc tca gac aca        590
Arg Glu Glu Leu Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr           
            160                 165                 170                   

tct gga gat ttt cgg aac gct ttg ctt tct ctt gct aag ggt gac cga        638
Ser Gly Asp Phe Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg           
        175                 180                 185                       

tct gag gac ttt ggt gtg aat gaa gac ttg gct gat tca gat gcc agg        686
Ser Glu Asp Phe Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg           
    190                 195                 200                           

gcc ttg tat gaa gca gga gaa agg aga aag ggg aca gac gta aac gtg        734
Ala Leu Tyr Glu Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val           
205                 210                 215                 220           

ttc aat acc atc ctt acc acc aga agc tat cca caa ctt cgc aga gtg        782
Phe Asn Thr Ile Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val           
                225                 230                 235               

ttt cag aaa tac acc aag tac agt aag cat gac atg aac aaa gtt ctg        830
Phe Gln Lys Tyr Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu           
            240                 245                 250                   

gac ctg gag ttg aaa ggt gac att gag aaa tgc ctc aca gct atc gtg        878
Asp Leu Glu Leu Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val           
        255                 260                 265                       

aag tgc gcc aca agc aaa cca gct ttc ttt gca gag aag ctt cat caa        926
Lys Cys Ala Thr Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln           
    270                 275                 280                           

gcc atg aaa ggt gtt gga act cgc cat aag gca ttg atc agg att atg        974
Ala Met Lys Gly Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met           
285                 290                 295                 300           

gtt tcc cgt tct gaa att gac atg aat gat atc aaa gca ttc tat cag       1022
Val Ser Arg Ser Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln           
                305                 310                 315               

aag atg tat ggt atc tcc ctt tgc caa gcc atc ctg gat gaa acc aaa       1070
Lys Met Tyr Gly Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys           
            320                 325                 330                   

gga gat tat gag aaa atc ctg gtg gct ctt tgt gga gga aac taa           1115
Gly Asp Tyr Glu Lys Ile Leu Val Ala Leu Cys Gly Gly Asn                   
        335                 340                 345                       

acattccctt gatggtctca agctatgatc agaagacttt aattatatat tttcatccta     1175

taagcttaaa taggaaagtt tcttcaacag gattacagtg tagctaccta catgctgaaa     1235

aatatagcct ttaaatcatt tttatattat aactctgtat aatagagata agtccatttt     1295

ttaaaaatgt tttccccaaa ccataaaacc ctatacaagt tgttctagta acaatacatg     1355

agaaagatgt ctatgtagct gaaaataaaa tgacgtcaca agac                      1399


<210>  2
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  3
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic ANXA1 peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal is acetylated

<400>  3

Lys Gln Ala Trp 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic ANXA1 peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal is optionally acetylated

<400>  4

Phe Gln Ala Trp 
1               


<210>  5
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic ANXA1 peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal is optionally acetylated

<400>  5

Phe Leu Lys Gln Ala Trp 
1               5       


<210>  6
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic ANXA1 peptide

<400>  6

Glu Phe Leu Lys Gln Ala Trp 
1               5           


<210>  7
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic ANXA1 peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal is optionally acetylated

<400>  7

Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp 
1               5                   10      


<210>  8
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic ANXA1 peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal is acetylated

<400>  8

Val Ser Glu Phe Leu Lys Gln Ala Trp 
1               5                   


<210>  9
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic ANXA1 peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal is acetylated

<400>  9

Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn Glu 
1               5                   10                  15      


Glu Gln Glu Tyr Val Gln Thr Val Lys 
            20                  25  


