                         SEQUENCE LISTING

<110>  Chen, Feng
       Grimm, Jan
       Baeriswyl, Jean-Luc
       Nitsch, Roger
       Hock, Christoph
       Panima Pharmaceuticals AG
       University of Zurich
 
<120>  HUMAN ANTI-TAU ANTIBODIES

<130>  2159.341PC02

<140>  To be assigned
<141>  Herewith

<150>  EP 10 013 494.9
<151>  2010-10-11

<150>  61/391,751
<151>  2010-10-11

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  352
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(352)
<223>  Isoform Fetal-Tau

<300>
<301>  Goedert M., Wischik C., Crowther R., Walker J., Klug A.
<302>  Cloning and sequencing of the cDNA encoding a core protein of the
        paired helical filament of Alzheimer disease: identification as 
       the microtubule-associated protein tau.
<303>  Proc. Natl. Acad. Sci. U.S.A.
<304>  85
<306>  4051-4055
<307>  1988-06-01

<300>
<308>  P10636-2
<309>  2010-10-05
<313>  (1)..(352)

<400>  1

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val 
    210                 215                 220                 


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
225                 230                 235                 240 


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
                245                 250                 255     


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr 
            260                 265                 270         


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
        275                 280                 285             


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
    290                 295                 300                 


Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser 
305                 310                 315                 320 


Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu 
                325                 330                 335     


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            340                 345                 350         


<210>  2
<211>  381
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(381)
<223>  Isoform Tau-B

<300>
<301>  Goedert M., Spillantini M.G., Jakes R., Rutherford D., Crowther 
       R.A.
<302>  Multiple isoforms of human microtubule-associated protein tau: 
       sequences and localization in neurofibrillary tangles of 
       Alzheimer's disease.
<303>  Neuron
<304>  3
<306>  519-526
<307>  1989-10-01

<300>
<308>  P10636-4
<309>  2010-10-05
<313>  (1)..(381)

<400>  2

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala 
    130                 135                 140                 


Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro 
145                 150                 155                 160 


Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
                165                 170                 175     


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
            180                 185                 190         


Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
        195                 200                 205             


Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu 
    210                 215                 220                 


Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
225                 230                 235                 240 


Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser 
                245                 250                 255     


Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro 
            260                 265                 270         


Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
        275                 280                 285             


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
    290                 295                 300                 


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu 
305                 310                 315                 320 


Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
                325                 330                 335     


Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser 
            340                 345                 350         


Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
        355                 360                 365             


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380     


<210>  3
<211>  410
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(410)
<223>  Isoform Tau-C

<300>
<301>  Goedert M., Spillantini M.G., Jakes R., Rutherford D., Crowther 
       R.A.
<302>  Multiple isoforms of human microtubule-associated protein tau: 
       sequences and localization in neurofibrillary tangles of 
       Alzheimer's disease.
<303>  Neuron
<304>  3
<306>  519-526
<307>  1989-10-01

<300>
<308>  P10636-5
<309>  2010-10-05
<313>  (1)..(410)

<400>  3

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr 
        275                 280                 285             


Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly 
    290                 295                 300                 


Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln 
305                 310                 315                 320 


Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly 
                325                 330                 335     


Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys 
            340                 345                 350         


Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val 
        355                 360                 365             


Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly 
    370                 375                 380                 


Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu 
385                 390                 395                 400 


Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410 


<210>  4
<211>  383
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(383)
<223>  Isoform Tau-D

<300>
<301>  Goedert M., Spillantini M.G., Potier M.-C., Ulrich J., Crowther 
       R.A.
<302>  Cloning and sequencing of the cDNA encoding an isoform of 
       microtubule-associated protein tau containing four tandem 
       repeats: differential expression of tau protein mRNAs in human 
       brain.
<303>  EMBO J.
<304>  8
<306>  393-399
<307>  1989-02-01

<300>
<308>  P10636-6
<309>  2010-10-05
<313>  (1)..(383)

<400>  4

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu 
    210                 215                 220                 


Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
225                 230                 235                 240 


His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp 
                245                 250                 255     


Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His 
            260                 265                 270         


Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
        275                 280                 285             


Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His 
    290                 295                 300                 


Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
305                 310                 315                 320 


Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
                325                 330                 335     


Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn 
            340                 345                 350         


Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala 
        355                 360                 365             


Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380             


<210>  5
<211>  412
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(412)
<223>  Isoform Tau-E

<300>
<301>  Goedert M., Spillantini M.G., Jakes R., Rutherford D., Crowther 
       R.A.
<302>  Multiple isoforms of human microtubule-associated protein tau: 
       sequences and localization in neurofibrillary tangles of 
       Alzheimer's disease.
<303>  Neuron
<304>  3
<306>  519-526
<307>  1989-10-01

<300>
<308>  P10636-7
<309>  2010-10-05
<313>  (1)..(412)

<400>  5

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala 
    130                 135                 140                 


Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro 
145                 150                 155                 160 


Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
                165                 170                 175     


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
            180                 185                 190         


Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
        195                 200                 205             


Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu 
    210                 215                 220                 


Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
225                 230                 235                 240 


Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser 
                245                 250                 255     


Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro 
            260                 265                 270         


Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
        275                 280                 285             


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
    290                 295                 300                 


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
305                 310                 315                 320 


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
                325                 330                 335     


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn 
            340                 345                 350         


Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
        355                 360                 365             


Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser 
    370                 375                 380                 


Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala 
385                 390                 395                 400 


Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410         


<210>  6
<211>  441
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(441)
<223>  Isoform Tau-F

<300>
<301>  Goedert M., Spillantini M.G., Jakes R., Rutherford D., Crowther 
       R.A.
<302>  Multiple isoforms of human microtubule-associated protein tau: 
       sequences and localization in neurofibrillary tangles of 
       Alzheimer's disease.
<303>  Neuron
<304>  3
<306>  519-526
<307>  1989-10-01

<300>
<308>  P10636-8
<309>  2010-10-05
<313>  (1)..(441)

<400>  6

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  7
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope recognized by NI-105.4E4 antibody


<220>
<221>  PEPTIDE
<222>  (1)..(7)
<223>  Epitope NI-105.4E4

<400>  7

Val Glu Val Lys Ser Glu Lys 
1               5           


<210>  8
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-105.4E4-VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(204)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (301)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  8
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gtc cag cct ggg gga         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aaa ctc tcc tgt gca gcc tct ggg ttc aat ttc aac atc tct         96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asn Ile Ser           
            20                  25                  30                    

gct ata cac tgg gtc cgc cag gct tcc ggg aaa ggg ctg gag tgg gtt        144
Ala Ile His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

ggc cga ata aga agt aaa tct cac aat tac gcg act tta tat gct gcg        192
Gly Arg Ile Arg Ser Lys Ser His Asn Tyr Ala Thr Leu Tyr Ala Ala           
    50                  55                  60                            

tcc ctg aaa ggc cgg ttc acc ctc tcc aga gat gat tca agg aac acg        240
Ser Leu Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Arg Asn Thr           
65                  70                  75                  80            

gcg tat ctg caa atg agc agc ctg caa acc gag gat atg gcc gtc tat        288
Ala Tyr Leu Gln Met Ser Ser Leu Gln Thr Glu Asp Met Ala Val Tyr           
                85                  90                  95                

tac tgt act gtt ctg agt gcg aat tac gac acc ttt gac tac tgg ggc        336
Tyr Cys Thr Val Leu Ser Ala Asn Tyr Asp Thr Phe Asp Tyr Trp Gly           
            100                 105                 110                   

cag gga acc ctg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  9
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asn Ile Ser 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ser His Asn Tyr Ala Thr Leu Tyr Ala Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Arg Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Ser Ser Leu Gln Thr Glu Asp Met Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Val Leu Ser Ala Asn Tyr Asp Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-105.4E4-VL variable light chain (VL) sequence wherein amino 
       acid sequence Ser-Tyr-Glu at positions 1-3 may also be 
       Leu-Pro-Val

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(291)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  10
tcc tat gag ctg act cag cca ccc tcg gtg tca gtg tcc cca gga cag         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

acg gcc agg atc tcc tgc ttt gga gat aca ttg cca aag caa tat act         96
Thr Ala Arg Ile Ser Cys Phe Gly Asp Thr Leu Pro Lys Gln Tyr Thr           
            20                  25                  30                    

tat tgg tat cag cag aag cct ggc cag gcc cct gtg tta gtg att tat        144
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr           
        35                  40                  45                        

aaa gac act gag agg ccc tca ggg atc ccc gag cga ttc tct ggc tcc        192
Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

agc tca ggg aca aca gtc acc ttg acc atc agt gga gtc cag gca gaa        240
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu           
65                  70                  75                  80            

gac gag gct gac tat tac tgt cta tca gct gac aac agt gct act tgg        288
Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Ala Asp Asn Ser Ala Thr Trp           
                85                  90                  95                

gtg ttc ggc gga ggg acc aag gtg acc gtc cta                            321
Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu                               
            100                 105                                       


<210>  11
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Phe Gly Asp Thr Leu Pro Lys Gln Tyr Thr 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Ala Asp Asn Ser Ala Thr Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  12
<211>  345
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(345)
<223>  NI-105.24B2-VH variable heavy chain (VH) sequence wherein Gln at 
       position 1 of the sequence may also be Glu

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(312)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  12
cag gtg cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tcg gtg aag gtt tcc tgt aag gca tct gga tac acc ttc gtc aat tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Val Asn Tyr           
            20                  25                  30                    

att ata cac tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga atc atc aat cct aat ggc gga aac aca agt tat gca gag aaa ttc        192
Gly Ile Ile Asn Pro Asn Gly Gly Asn Thr Ser Tyr Ala Glu Lys Phe           
    50                  55                  60                            

cag gcc cga gtc acc ttg acc agc gac acg tct acg agt acg gtg tac        240
Gln Ala Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr           
65                  70                  75                  80            

atg gac ctg agc agc ctg aca tct gag gac acg gcc gtc tat tac tgt        288
Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcc gtc ctt tcc cct tcg aat ccc tgg ggc cag ggg acc acg gtc acc        336
Ala Val Leu Ser Pro Ser Asn Pro Trp Gly Gln Gly Thr Thr Val Thr           
            100                 105                 110                   

gtc tcc tcg                                                            345
Val Ser Ser                                                               
        115                                                               


<210>  13
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Val Asn Tyr 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Asn Gly Gly Asn Thr Ser Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Ala Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Leu Ser Pro Ser Asn Pro Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  14
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-105.24B2-VL variable light chain (VL) sequence wherein Glu at 
       position 3 in the sequence may also be Val

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(294)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  14
tcc tat gag ctg act cag cca ccc tcg gtg tca gtg tcc cca gga cag         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

acg gcc ggg atc acc tgc tct gga gat gct ttg cca aag caa ttt gtt         96
Thr Ala Gly Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Phe Val           
            20                  25                  30                    

tat tgg tac cag aag aag cca ggc cag gcc cct gtg tta ttg ata tat        144
Tyr Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Ile Tyr           
        35                  40                  45                        

aaa gac act gag agg ccc tca cga atc cct gag cgc ttc tct ggc tcc        192
Lys Asp Thr Glu Arg Pro Ser Arg Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

acc tca ggg aca aca gtc gcg ttg acc atc aat ggg gtc cag gca gag        240
Thr Ser Gly Thr Thr Val Ala Leu Thr Ile Asn Gly Val Gln Ala Glu           
65                  70                  75                  80            

gac gag gct gac tat tac tgt caa tca gcc gac cgc agt ggt gct ctt        288
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Arg Ser Gly Ala Leu           
                85                  90                  95                

tgg gtg ttc ggc gga ggg acc aag ctg acc gtc cta                        324
Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                           
            100                 105                                       


<210>  15
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Gly Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Phe Val 
            20                  25                  30          


Tyr Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Ile Tyr 
        35                  40                  45              


Lys Asp Thr Glu Arg Pro Ser Arg Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Thr Thr Val Ala Leu Thr Ile Asn Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Arg Ser Gly Ala Leu 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  16
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  NI-105.4A3-VH variable heavy chain (VH) sequence wherein Gln at 
       positon 1 of the sequence may also be Glu and Ser at position 7 
       of the sequence may also be Thr

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(345)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  16
cag gtg cag ctg gtg gag tct ggg gga ggc gcg gtc cag cct ggg ggg         48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ala Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt gac tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr           
            20                  25                  30                    

gcc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg cag tgg gtg        144
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val           
        35                  40                  45                        

gca gtt ata tcg tat gag gga act tat aaa tac tat gca gac tcc gtg        192
Ala Val Ile Ser Tyr Glu Gly Thr Tyr Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac acg ctg aac        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asn           
65                  70                  75                  80            

ttg cag atg agc agc ctg aga gtt gaa gac acg gct gtg tat ttc tgt        288
Leu Gln Met Ser Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gtg aaa gct cga gcc ttt gcc tcc gga cag cga agc acc tcc acc gta        336
Val Lys Ala Arg Ala Phe Ala Ser Gly Gln Arg Ser Thr Ser Thr Val           
            100                 105                 110                   

cct gac tac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                378
Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  17
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ala Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Glu Gly Thr Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Lys Ala Arg Ala Phe Ala Ser Gly Gln Arg Ser Thr Ser Thr Val 
            100                 105                 110         


Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  18
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-105.4A3-VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(294)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  18
tcc tat gag ctg act cag cca ccc tcg gtg tca gtg tcc cca gga caa         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

acg gcc agg atc acc tgc tct gga gat gca ttg cca aaa aaa tat gct         96
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala           
            20                  25                  30                    

tat tgg tac cag cag aag tca ggc cag gcc cct gtg ttg gtc atc tat        144
Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr           
        35                  40                  45                        

gag gac aac aaa cga ccc tcc ggg atc cct gag aga ttc tct ggc tcc        192
Glu Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

agc tca ggg aca gtg gcc acc ttg act atc agt ggg gcc cag gtg gac        240
Ser Ser Gly Thr Val Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Asp           
65                  70                  75                  80            

gat gaa gct gac tac tac tgc tac tcg aca gac atc agt ggt gac ctt        288
Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ile Ser Gly Asp Leu           
                85                  90                  95                

cgg gtg ttc ggc gga ggg acc aag ctg acc gtc ctc                        324
Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                           
            100                 105                                       


<210>  19
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Val Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Asp 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ile Ser Gly Asp Leu 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  20
<211>  451
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mature ch4E4 heavy chain (mouse IgG2a)

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asn Ile Ser 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ser His Asn Tyr Ala Thr Leu Tyr Ala Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Arg Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Ser Ser Leu Gln Thr Glu Asp Met Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Val Leu Ser Ala Asn Tyr Asp Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
    210                 215                 220                 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
                245                 250                 255     


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
            260                 265                 270         


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
        275                 280                 285             


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
    290                 295                 300                 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
        355                 360                 365             


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
    370                 375                 380                 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
                405                 410                 415     


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
            420                 425                 430         


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  21
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mature ch4E4 light chain (mouse lambda)

<400>  21

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Phe Gly Asp Thr Leu Pro Lys Gln Tyr Thr 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Ala Asp Asn Ser Ala Thr Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys Ser 
            100                 105                 110         


Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Glu Thr 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr Pro Gly Val 
    130                 135                 140                 


Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr Gln Gly Met 
145                 150                 155                 160 


Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr Met Ala Ser 
                165                 170                 175     


Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His Ser Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys Ser Leu Ser 
        195                 200                 205             


Arg Ala Asp Cys Ser 
    210             


<210>  22
<211>  451
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mature ch4E4(N30Q) heavy chain (mouse IgG2a)

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Gln Ile Ser 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ser His Asn Tyr Ala Thr Leu Tyr Ala Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Arg Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Ser Ser Leu Gln Thr Glu Asp Met Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Val Leu Ser Ala Asn Tyr Asp Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
    210                 215                 220                 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
                245                 250                 255     


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
            260                 265                 270         


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
        275                 280                 285             


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
    290                 295                 300                 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
        355                 360                 365             


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
    370                 375                 380                 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
                405                 410                 415     


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
            420                 425                 430         


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  23
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4E4-VH (variable heavy chain sequence VH) CDR1

<400>  23

Ile Ser Ala Ile His 
1               5   


<210>  24
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4E4-VH (variable heavy chain sequence VH) CDR2

<400>  24

Arg Ile Arg Ser Lys Ser His Asn Tyr Ala Thr Leu Tyr Ala Ala Ser 
1               5                   10                  15      


Leu Lys Gly 
            


<210>  25
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4E4-VH (variable heavy chain sequence VH) CDR3

<400>  25

Leu Ser Ala Asn Tyr Asp Thr Phe Asp Tyr 
1               5                   10  


<210>  26
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4E4-VL (variable light chain sequence VL) CDR1

<400>  26

Phe Gly Asp Thr Leu Pro Lys Gln Tyr Thr Tyr 
1               5                   10      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4E4-VL (variable light chain sequence VL) CDR2

<400>  27

Lys Asp Thr Glu Arg Pro Ser 
1               5           


<210>  28
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4E4-VL (variable light chain sequence VL) CD3

<400>  28

Leu Ser Ala Asp Asn Ser Ala Thr Trp Val 
1               5                   10  


<210>  29
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.24B2-VH (variable heavy chain sequence VH) CDR1

<400>  29

Asn Tyr Ile Ile His 
1               5   


<210>  30
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.24B2-VH (variable heavy chain sequence VH) CD2

<400>  30

Ile Ile Asn Pro Asn Gly Gly Asn Thr Ser Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Ala 
    


<210>  31
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.24B2-VH (variable heavy chain sequence VH) CDR3

<400>  31

Leu Ser Pro Ser Asn Pro 
1               5       


<210>  32
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.24B2-VL (variable light chain sequence VL) CDR1

<400>  32

Ser Gly Asp Ala Leu Pro Lys Gln Phe Val Tyr 
1               5                   10      


<210>  33
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.24B2-VL (variable light chain sequence VL) CDR2

<400>  33

Lys Asp Thr Glu Arg Pro Ser 
1               5           


<210>  34
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.24B2-VL (variable light chain sequence VL) CDR3

<400>  34

Gln Ser Ala Asp Arg Ser Gly Ala Leu Trp Val 
1               5                   10      


<210>  35
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4A3-VH (variable heavy chain sequence VH) CDR1

<400>  35

Asp Tyr Ala Met His 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4A3-VH (variable heavy chain sequence VH) CDR2

<400>  36

Val Ile Ser Tyr Glu Gly Thr Tyr Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4A3-VH (variable heavy chain sequence VH) CDR3

<400>  37

Ala Arg Ala Phe Ala Ser Gly Gln Arg Ser Thr Ser Thr Val Pro Asp 
1               5                   10                  15      


Tyr 
    


<210>  38
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4A3-VL (variable light chain sequence VL) CDR1

<400>  38

Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala Tyr 
1               5                   10      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4A3-VL (variable light chain sequence VL) CDR2

<400>  39

Glu Asp Asn Lys Arg Pro Ser 
1               5           


<210>  40
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NI-105.4A3-VL (variable light chain sequence VL) CDR3

<400>  40

Tyr Ser Thr Asp Ile Ser Gly Asp Leu Arg Val 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide

<400>  41

Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
1               5                   10      


<210>  42
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide

<400>  42

Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  43

Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  44

Ala Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  45

Gly Ala Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  46

Gly Gln Ala Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  47

Gly Gln Val Ala Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  48

Gly Gln Val Glu Ala Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  49

Gly Gln Val Glu Val Ala Ser Glu Lys Leu Asp Phe Lys Asp Arg 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  50

Gly Gln Val Glu Val Lys Ala Glu Lys Leu Asp Phe Lys Asp Arg 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  51

Gly Gln Val Glu Val Lys Ser Ala Lys Leu Asp Phe Lys Asp Arg 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  52

Gly Gln Val Glu Val Lys Ser Glu Ala Leu Asp Phe Lys Asp Arg 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  53

Gly Gln Val Glu Val Lys Ser Glu Lys Ala Asp Phe Lys Asp Arg 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  54

Gly Gln Val Glu Val Lys Ser Glu Lys Leu Ala Phe Lys Asp Arg 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  55

Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Ala Lys Asp Arg 
1               5                   10                  15  


<210>  56
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  56

Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Ala Asp Arg 
1               5                   10                  15  


<210>  57
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  57

Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Ala Arg 
1               5                   10                  15  


<210>  58
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  58

Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Ala 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  59

Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  60

Ala Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  61

Lys Gly Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  62

Lys Pro Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  63

Lys Ala Ala Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  64

Lys Ala Lys Ala Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  65

Lys Ala Lys Thr Ala His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  66

Lys Ala Lys Thr Asp Ala Gly Ala Glu Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  67

Lys Ala Lys Thr Asp His Ala Ala Glu Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  68

Lys Ala Lys Thr Asp His Gly Gly Glu Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  69

Lys Ala Lys Thr Asp His Gly Pro Glu Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  70

Lys Ala Lys Thr Asp His Gly Ala Ala Ile Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  71

Lys Ala Lys Thr Asp His Gly Ala Glu Ala Val Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  72

Lys Ala Lys Thr Asp His Gly Ala Glu Ile Ala Tyr Lys Ser Pro 
1               5                   10                  15  


<210>  73
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  73

Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Ala Lys Ser Pro 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  74

Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Ala Ser Pro 
1               5                   10                  15  


<210>  75
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  75

Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ala Pro 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine mutagenesis 4E4 epitope

<400>  76

Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Ala 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  77

Ala Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  78

Gln Ala Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  79

Gln Glu Ala Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  80

Gln Glu Gly Ala Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  81

Gln Glu Gly Asp Ala Asp Ala Gly Leu Lys Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  82

Gln Glu Gly Asp Thr Ala Ala Gly Leu Lys Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  83
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  83

Gln Glu Gly Asp Thr Asp Gly Gly Leu Lys Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  84

Gln Glu Gly Asp Thr Asp Pro Gly Leu Lys Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  85

Gln Glu Gly Asp Thr Asp Ala Ala Leu Lys Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  86

Gln Glu Gly Asp Thr Asp Ala Gly Ala Lys Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  87

Gln Glu Gly Asp Thr Asp Ala Gly Leu Ala Glu Ser Pro Leu Gln 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  88

Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Ser Pro Leu Gln 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  89

Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ala Pro Leu Gln 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  90

Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Ala Leu Gln 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  91

Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Ala Gln 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Alanine Mutagenesis

<400>  92

Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu Ala 
1               5                   10                  15  


<210>  93
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH antibody

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Gln Ile Ser 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ser His Asn Tyr Ala Thr Leu Tyr Ala Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Arg Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Ser Ser Leu Gln Thr Glu Asp Met Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Val Leu Ser Ala Asn Tyr Asp Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120   