                         SEQUENCE LISTING

<110>  LFB Biotechnologies
       LFB Biotechnologies
 
<120>  Utilisation d'un anticorps anti-CD20 pour le traitement du 
       lymphome crbral primitif

<130>  BIP207281PC00

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  318
<212>  DNA
<213>  Mus sp.

<400>  1
caaattgttc tctcccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca       60

atgacttgca gggccagctc aagtgtaagt tacatgcact ggtaccagca gaagccagga      120

tcctccccca aaccctggat ttatgccaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttat tctttcacaa tcagcagagt ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg acttttaacc cacccacgtt cggagggggg      300

accaggctgg aaataaaa                                                    318


<210>  2
<211>  354
<212>  DNA
<213>  Mus sp.

<400>  2
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacaata tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggaggt atttatccag gaaatggtga tacttcctac      180

aatcagaagt tcaagggcaa ggccacactg actgtaggca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaagac tctgcggtct atttctgtgc aagatatgac      300

tacaactatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  3
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  3
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  4
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  4
cggactgtgg ctgcaccaag tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  5
<211>  639
<212>  DNA
<213>  Artificial

<220>
<223>  Chimrique Souris (Mus sp.) - Humain (Homo sapiens)

<400>  5
caaattgttc tctcccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca       60

atgacttgca gggccagctc aagtgtaagt tacatgcact ggtaccagca gaagccagga      120

tcctccccca aaccctggat ttatgccaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttat tctttcacaa tcagcagagt ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg acttttaacc cacccacgtt cggagggggg      300

accaggctgg aaataaaacg gactgtggct gcaccaagtg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             639


<210>  6
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  Chimrique Souris (Mus sp.) - Humain (Homo sapiens)

<400>  6
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacaata tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggaggt atttatccag gaaatggtga tacttcctac      180

aatcagaagt tcaagggcaa ggccacactg actgtaggca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaagac tctgcggtct atttctgtgc aagatatgac      300

tacaactatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctcagcctcc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  7
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  Chimrique Souris (Mus sp.) - Humain (Homo sapiens)

<400>  7

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Phe Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  8
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  Chimrique Souris (Mus sp.) - Humain (Homo sapiens)

<400>  8

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Gly Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  9
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Amorces de transcription inverse : Amorce antisens spcifique 
       Kappa murin

<400>  9
actgccatca atcttccact tgac                                              24


<210>  10
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Amorces de transcription inverse : Amorce antisens spcifique G2a
       murin

<400>  10
ctgagggtgt agaggtcaga ctg                                               23


<210>  11
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Amorces de PCR 5'RACE : Amorce antisens spcifique Kappa murin

<400>  11
ttgttcaaga agcacacgac tgaggcac                                          28


<210>  12
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Amorces de PCR 5'RACE : Amorce antisens spcifique G2a murin

<400>  12
gagttccagg tcaaggtcac tggctcag                                          28


<210>  13
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Vecteur chane lgre Kappa de l'anticorps EMAB603 : amorce sens 
       VK

<400>  13
ctcagtacta gtgccgccac catggatttt caagtgcaga ttttcag                     47


<210>  14
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Vecteur chane lgre Kappa de l'anticorps EMAB603 : amorce 
       antisens VK

<400>  14
tgaagacact tggtgcagcc acagtccgtt ttatttccag cctggt                      46


<210>  15
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Vecteur chane lourde : amorce sens VH

<400>  15
ctcagtacta gtgccgccac catgggattc agcaggatct ttctc                       45


<210>  16
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Vecteur chane lourde : amorce antisens VH

<400>  16
gaccgatggg cccttggtgg aggctgagga gacggtgact gaggttcc                    48


<210>  17
<211>  11141
<212>  DNA
<213>  Artificial

<220>
<223>  Squence brute du plasmide HK463-25

<400>  17
gatctcccga tcccctatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa       60

gccagtatct gctccctgct tgtgtgttgg aggtcgctga gtagtgcgcg agcaaaattt      120

aagctacaac aaggcaaggc ttgaccgaca attgcatgaa gaatctgctt agggttaggc      180

gttttgcgct gcttcgcgat gtacgggcca gatatacgcg tatctgaggg gactagggtg      240

tgtttaggcg aaaagcgggg cttcggttgt acgcggttag gagtcccctc aggatatagt      300

agtttcgctt ttgcataggg agggggaaat gtagtcttat gcaatactct tgtagtcttg      360

caacatggta acgatgagtt agcaacatgc cttacaagga gagaaaaagc accgtgcatg      420

ccgattggtg gaagtaaggt ggtacgatcg tgccttatta ggaaggcaac agacgggtct      480

gacatggatt ggacgaacca ctgaattccg cattgcagag atattgtatt taagtgccta      540

gctcgataca ataaacgcca tttgaccatt caccacattg gtgtgcacct ccaagcttgg      600

taccgagctc ggatccacta gagcagaagt tggtcgtgag gcactgggca ggtaagtatc      660

aaggttacaa gacaggttta aggagaccaa tagaaactgg gcttgtcgag acagagaaga      720

ctcttgcgtt tctgataggc acctattggt cttactgaca tccactttgc ctttctctcc      780

acaggtgtcc actcccagtt caattacagc tcttgctagc gccgccacca tgggattcag      840

caggatcttt ctcttcctcc tgtcagtaac tacaggtgtc cactcccagg cttatctaca      900

gcagtctggg gctgagctgg tgaggcctgg ggcctcagtg aagatgtcct gcaaggcttc      960

tggctacaca tttaccagtt acaatatgca ctgggtaaag cagacaccta gacagggcct     1020

ggaatggatt ggaggtattt atccaggaaa tggtgatact tcctacaatc agaagttcaa     1080

gggcaaggcc acactgactg taggcaaatc ctccagcaca gcctacatgc agctcagcag     1140

cctgacatct gaagactctg cggtctattt ctgtgcaaga tatgactaca actatgctat     1200

ggactactgg ggtcaaggaa cctcagtcac cgtctcctca gcctccacca agggcccatc     1260

ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg     1320

cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac     1380

cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag     1440

cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca     1500

caagcccagc aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca     1560

cacatgccca ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc     1620

cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt     1680

ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt     1740

gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag     1800

cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc     1860

caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg     1920

agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag     1980

cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa     2040

tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt     2100

cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc     2160

atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc     2220

tccgggtaaa tgatagggcg cgccgctaga gaggatcccg ggtggcatcc ctgtgacccc     2280

tccccagtgc ctctcctggc cctggaagtt gccactccag tgcccaccag ccttgtccta     2340

ataaaattaa gttgcatcat tttgtctgac taggtgtcct tctataatat tatggggtgg     2400

aggggggtgg tatggagcaa ggggcaagtt gggaagacaa cctgtagggc ctgcggggtc     2460

tattgggaac caagctggag tgcagtggca caatcttggc tcactgcaat ctccgcctcc     2520

tgggttcaag cgattctcct gcctcagcct cccgagttgt tgggattcca ggcatgcatg     2580

accaggctca gctaattttt gtttttttgg tagagacggg gtttcaccat attggccagg     2640

ctggtctcca actcctaatc tcaggtgatc tacccacctt ggcctcccaa attgctggga     2700

ttacaggcgt gaaccactgc tcccttccct gtccttctga ttttaaaata actataccag     2760

caggaggacg tccagacaca gcataggcta cctggccatg cccaaccggt gggacatttg     2820

agttgcttgc ttggcactgt cctctcatgc gttgggtcca ctcagtagat gcctgttcat     2880

atgctcgaga tctcccgatc ccctatggtg cactctcagt acaatctgct ctgatgccgc     2940

atagttaagc cagtatctgc tccctgcttg tgtgttggag gtcgctgagt agtgcgcgag     3000

caaaatttaa gctacaacaa ggcaaggctt gaccgacaat tgcatgaaga atctgcttag     3060

ggttaggcgt tttgcgctgc ttcgcgatgt acgggccaga tatacgcgta tctgagggga     3120

ctagggtgtg tttaggcgaa aagcggggct tcggttgtac gcggttagga gtcccctcag     3180

gatatagtag tttcgctttt gcatagggag ggggaaatgt agtcttatgc aatactcttg     3240

tagtcttgca acatggtaac gatgagttag caacatgcct tacaaggaga gaaaaagcac     3300

cgtgcatgcc gattggtgga agtaaggtgg tacgatcgtg ccttattagg aaggcaacag     3360

acgggtctga catggattgg acgaaccact gaattccgca ttgcagagat attgtattta     3420

agtgcctagc tcgatacaat aaacgccatt tgaccattca ccacattggt gtgcacctcc     3480

aagcttggta ccgagctcgg atccactaga gcagaagttg gtcgtgaggc actgggcagg     3540

taagtatcaa ggttacaaga caggtttaag gagaccaata gaaactgggc ttgtcgagac     3600

agagaagact cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct     3660

ttctctccac aggtgtccac tcccagttca attacagctc ttactagtgc cgccaccatg     3720

gattttcaag tgcagatttt cagcttcctg ctaatcagtg cttcagtcat aatgtccaga     3780

ggacaaattg ttctctccca gtctccagca atcctgtctg catctccagg ggagaaggtc     3840

acaatgactt gcagggccag ctcaagtgta agttacatgc actggtacca gcagaagcca     3900

ggatcctccc ccaaaccctg gatttatgcc acatccaacc tggcttctgg agtccctgct     3960

cgcttcagtg gcagtgggtc tgggacctct tattctttca caatcagcag agtggaggct     4020

gaagatgctg ccacttatta ctgccagcag tggactttta acccacccac gttcggaggg     4080

gggaccaggc tggaaataaa acggactgtg gctgcaccaa gtgtcttcat cttcccgcca     4140

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     4200

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     4260

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     4320

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     4380

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttagtgaac tctagagagg     4440

atcccgggtg gcatccctgt gacccctccc cagtgcctct cctggccctg gaagttgcca     4500

ctccagtgcc caccagcctt gtcctaataa aattaagttg catcattttg tctgactagg     4560

tgtccttcta taatattatg gggtggaggg gggtggtatg gagcaagggg caagttggga     4620

agacaacctg tagggcctgc ggggtctatt gggaaccaag ctggagtgca gtggcacaat     4680

cttggctcac tgcaatctcc gcctcctggg ttcaagcgat tctcctgcct cagcctcccg     4740

agttgttggg attccaggca tgcatgacca ggctcagcta atttttgttt ttttggtaga     4800

gacggggttt caccatattg gccaggctgg tctccaactc ctaatctcag gtgatctacc     4860

caccttggcc tcccaaattg ctgggattac aggcgtgaac cactgctccc ttccctgtcc     4920

ttctgatttt aaaataacta taccagcagg aggacgtcca gacacagcat aggctacctg     4980

gccatgccca accggtggga catttgagtt gcttgcttgg cactgtcctc tcatgcgttg     5040

ggtccactca gtagatgcct gttcatatgc tcgagattta aatactgggg ctcgactgtg     5100

gaatgtgtgt cagttagggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca     5160

aagcatgcat ctcaattagt cagcaaccag gtgtggaaag tccccaggct ccccagcagg     5220

cagaagtatg caaagcatgc atctcaatta gtcagcaacc atagtcccgc ccctaactcc     5280

gcccatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat     5340

tttttttatt tatgcagagg ccgaggccgc ctcggcctct gagctattcc agaagtagtg     5400

aggaggcttt tttggaggcc taggcttttg caaaaagctt gggggggggg acagctcagg     5460

gctgcgattt cgcgccaaac ttgacggcaa tcctagcgtg aaggctggta ggattttatc     5520

cccgctgcca tcatggttcg accattgaac tgcatcgtcg ccgtgtccca aaatatgggg     5580

attggcaaga acggagacct accctggcct ccgctcagga acgagttcaa gtacttccaa     5640

agaatgacca caacctcttc agtggaaggt aaacagaatc tggtgattat gggtaggaaa     5700

acctggttct ccattcctga gaagaatcga cctttaaagg acagaattaa tatagttctc     5760

agtagagaac tcaaagaacc accacgagga gctcattttc ttgccaaaag tttggatgat     5820

gccttaagac ttattgaaca accggaattg gcaagtaaag tagacatggt ttggatagtc     5880

ggaggcagtt ctgtttacca ggaagccatg aatcaaccag gccacctcag actctttgtg     5940

acaaggatca tgcaggaatt tgaaagtgac acgtttttcc cagaaattga tttggggaaa     6000

tataaacttc tcccagaata cccaggcgtc ctctctgagg tccaggagga aaaaggcatc     6060

aagtataagt ttgaagtcta cgagaagaaa gactaacagg aagatgcttt caagttctct     6120

gctcccctcc taaagctatg catttttata agaccatggg acttttgctg gctttagatc     6180

gatctttgtg aaggaacctt acttctgtgg tgtgacataa ttggacaaac tacctacaga     6240

gatttaaagc tctaaggtaa atataaaatt tttaagtgta taatgtgtta aactactgat     6300

tctaattgtt tgtgtatttt agattccaac ctatggaact gatgaatggg agcagtggtg     6360

gaatgccttt aatgaggaaa acctgttttg ctcagaagaa atgccatcta gtgatgatga     6420

ggctactgct gactctcaac attctactcc tccaaaaaag aagagaaagg tagaagaccc     6480

caaggacttt ccttcagaat tgctaagttt tttgagtcat gctgtgttta gtaatagaac     6540

tcttgcttgc tttgctattt acaccacaaa ggaaaaagct gcactgctat acaagaaaat     6600

tatggaaaaa tattctgtaa cctttataag taggcataac agttataatc ataacatact     6660

gttttttctt actccacaca ggcatagagt gtctgctatt aataactatg ctcaaaaatt     6720

gtgtaccttt agctttttaa tttgtaaagg ggttaataag gaatatttga tgtatagtgc     6780

cttgactaga gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa     6840

acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact     6900

tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata     6960

aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc     7020

atgtctggat ccgcgtatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa     7080

gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg     7140

catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac     7200

cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta     7260

atgtcatgat aataatggtt tcttagagat ctcgagggtg ggccatcgcc ctgatagacg     7320

gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact     7380

ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt     7440

tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa     7500

atattaacgc ttacaatttc ctgatgcggt attttctcct tacgcatctg tgcggtattt     7560

cacaccgcat acgcggatct gcgcagcacc atggcctgaa ataacctctg aaagaggaac     7620

ttggttaggt accttctgag gcggaaagaa ccagctgtgg aatgtgtgtc agttagggtg     7680

tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc     7740

agcaaccagg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca     7800

tctcaattag tcagcaacca tagtcccgcc cctaactccg cccatcccgc ccctaactcc     7860

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc     7920

cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct     7980

aggcttttgc aaaaagcttg attcttctga cacaacagtc tcgaacttaa ggctagagcc     8040

accatgattg aacaagatgg attgcacgca ggttctccgg ccgcttgggt ggagaggcta     8100

ttcggctatg actgggcaca acagacaatc ggctgctctg atgccgccgt gttccggctg     8160

tcagcgcagg ggcgcccggt tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa     8220

ctgcaggacg aggcagcgcg gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct     8280

gtgctcgacg ttgtcactga agcgggaagg gactggctgc tattgggcga agtgccgggg     8340

caggatctcc tgtcatctca ccttgctcct gccgagaaag tatccatcat ggctgatgca     8400

atgcggcggc tgcatacgct tgatccggct acctgcccat tcgaccacca agcgaaacat     8460

cgcatcgagc gagcacgtac tcggatggaa gccggtcttg tcgatcagga tgatctggac     8520

gaagagcatc aggggctcgc gccagccgaa ctgttcgcca ggctcaaggc gcgcatgccc     8580

gacggcgagg atctcgtcgt gacccatggc gatgcctgct tgccgaatat catggtggaa     8640

aatggccgct tttctggatt catcgactgt ggccggctgg gtgtggcgga ccgctatcag     8700

gacatagcgt tggctacccg tgatattgct gaagagcttg gcggcgaatg ggctgaccgc     8760

ttcctcgtgc tttacggtat cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt     8820

cttgacgagt tcttctgagc gggactctgg ggttcgaaat gaccgaccaa gcgacgccca     8880

acctgccatc acgatggccg caataaaata tctttatttt cattacatct gtgtgttggt     8940

tttttgtgtg aatcgatagc gataaggatc gatcctctag ctagagtcga tcgacctgca     9000

gggatccgcg tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag     9060

ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc     9120

gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca     9180

tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc     9240

atgataataa tggtttctta gagatcttag atatccggac gtgtatacca gtttaaacat     9300

gttaattaag tcgacgcggc cgcaggtggc acttttcggg gaaatgtgcg cggaacccct     9360

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     9420

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     9480

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     9540

aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc     9600

aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact     9660

tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc     9720

ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag     9780

catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat     9840

aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt     9900

ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa     9960

gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc    10020

aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg    10080

gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt    10140

gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca    10200

gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat    10260

gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca    10320

gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg    10380

atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg    10440

ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt    10500

ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg    10560

ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata    10620

ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca    10680

ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag    10740

tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc    10800

tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga    10860

tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg    10920

tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac    10980

gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg    11040

tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg    11100

ttcctggcct tttgctggcc ttttgctcac atggctcgac a                        11141


