                         SEQUENCE LISTING<110> MedImmune Limited<120>  Therapies for improving pulmonary function<130>  MED0593.PRO<140>  <141>  <150>  <151>  <150>  <151>  <150>  <151>  <150>  <151>  
<160>  249   <170>  PatentIn version 3.1<210>  1<211>  5<212>  PRT<213>  Homo sapiens<400>  1

Asn Tyr Gly Leu Ser 
1               5   


<210>  2<211>  17<212>  PRT<213>  Homo sapiens<400>  2

Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe Gln Gly 
1               5                   10                  15      


<210>  3<211>  13<212>  PRT<213>  Homo sapiens<400>  3

Asp Ser Ser Ser Asn Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  4<211>  11<212>  PRT<213>  Homo sapiens<400>  4

Gly Gly Asn Asn Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  5<211>  7<212>  PRT<213>  Homo sapiens<400>  5

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  6<211>  11<212>  PRT<213>  Homo sapiens<400>  6

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      


<210>  7<211>  5<212>  PRT<213>  Homo sapiens<400>  7

Asn Tyr Gly Leu Ser 
1               5   


<210>  8<211>  17<212>  PRT<213>  Homo sapiens<400>  8

Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe Gln Gly 
1               5                   10                  15      


<210>  9<211>  13<212>  PRT<213>  Homo sapiens<400>  9

Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  10<211>  11<212>  PRT<213>  Homo sapiens<400>  10

Gly Gly Asn Ile Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  11<211>  7<212>  PRT<213>  Homo sapiens<400>  11

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  12<211>  11<212>  PRT<213>  Homo sapiens<400>  12

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      


<210>  13<211>  122<212>  PRT<213>  Homo sapiens<400>  13

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Met Thr Thr Glu Thr Ser Thr Asn Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Ser Ser Asn Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Lys Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  14<211>  108<212>  PRT<213>  Homo sapiens<400>  14

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Pro Cys Gly Gly Asn Asn Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ile Asp Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  15<211>  122<212>  PRT<213>  Homo sapiens<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  16<211>  108<212>  PRT<213>  Homo sapiens<400>  16

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  17<211>  30<212>  PRT<213>  Homo sapiens<400>  17

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg 
            20                  25                  30  


<210>  18<211>  14<212>  PRT<213>  Homo sapiens<400>  18

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  19<211>  32<212>  PRT<213>  Homo sapiens<400>  19

Arg Ile Thr Met Thr Thr Glu Thr Ser Thr Asn Thr Ala His Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210>  20<211>  22<212>  PRT<213>  Homo sapiens<400>  20

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Pro Cys 
            20          


<210>  21<211>  15<212>  PRT<213>  Homo sapiens<400>  21

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
1               5                   10                  15  


<210>  22<211>  32<212>  PRT<213>  Homo sapiens<400>  22

Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Ile Asp Ala Gly Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  23<211>  120<212>  PRT<213>  Homo sapiens<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Ala Ala Gly Glu Gly Tyr Tyr Gly Tyr Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  24<211>  110<212>  PRT<213>  Homo sapiens<400>  24

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Asp Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Asn Asn Asp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  25<211>  123<212>  PRT<213>  Homo sapiens<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Ser Ile Ser Ala Ser Gly Asp Ser Thr Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asn Lys Asn Met Val 
65                  70                  75                  80  


Phe Leu Gln Val Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Lys Asp Trp Ser Gln Trp Leu Val Gly Asp Ala Phe Asp Val 
            100                 105                 110         


Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  26<211>  108<212>  PRT<213>  Homo sapiens<400>  26

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Leu Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Gly Ser Thr Leu Gln Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Thr Phe Ser Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala 
            100                 105             


<210>  27<211>  30<212>  PRT<213>  Homo sapiens<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  28<211>  14<212>  PRT<213>  Homo sapiens<400>  28

Trp Tyr Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  29<211>  32<212>  PRT<213>  Homo sapiens<400>  29

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  30<211>  22<212>  PRT<213>  Homo sapiens<400>  30

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys 
            20          


<210>  31<211>  15<212>  PRT<213>  Homo sapiens<400>  31

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
1               5                   10                  15  


<210>  32<211>  32<212>  PRT<213>  Homo sapiens<400>  32

Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  33<211>  122<212>  PRT<213>  Homo sapiens<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Lys Ala Thr Thr Glu Glu Gly Tyr Tyr Gly Tyr Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  34<211>  110<212>  PRT<213>  Homo sapiens<400>  34

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Asp Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Asn Asn Asp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  35<211>  122<212>  PRT<213>  Homo sapiens<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Glu Gln Thr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  36<211>  108<212>  PRT<213>  Homo sapiens<400>  36

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  37<211>  122<212>  PRT<213>  Homo sapiens<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Tyr Asp Gly Gly Asn Thr Gln Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  38<211>  108<212>  PRT<213>  Homo sapiens<400>  38

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  39<211>  122<212>  PRT<213>  Homo sapiens<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Leu Asn Gly Glu Thr Leu Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  40<211>  108<212>  PRT<213>  Homo sapiens<400>  40

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  41<211>  122<212>  PRT<213>  Homo sapiens<400>  41

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ala Thr Pro Asp Gly Gln Thr Ser Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Asn Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  42<211>  108<212>  PRT<213>  Homo sapiens<400>  42

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  43<211>  122<212>  PRT<213>  Homo sapiens<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asp Thr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  44<211>  108<212>  PRT<213>  Homo sapiens<400>  44

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  45<211>  122<212>  PRT<213>  Homo sapiens<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Ser Asn Gly Tyr Thr Ser Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  46<211>  108<212>  PRT<213>  Homo sapiens<400>  46

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  47<211>  122<212>  PRT<213>  Homo sapiens<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Asp Ala Thr Gly Asp Thr Gln Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  48<211>  108<212>  PRT<213>  Homo sapiens<400>  48

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  49<211>  122<212>  PRT<213>  Homo sapiens<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Arg Asn Ile Asp Gly Tyr Thr Ile Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  50<211>  108<212>  PRT<213>  Homo sapiens<400>  50

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  51<211>  122<212>  PRT<213>  Homo sapiens<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Asp Asp Ser Gly Thr Thr Ile Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  52<211>  108<212>  PRT<213>  Homo sapiens<400>  52

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  53<211>  122<212>  PRT<213>  Homo sapiens<400>  53

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Thr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  54<211>  108<212>  PRT<213>  Homo sapiens<400>  54

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  55<211>  5<212>  PRT<213>  Homo sapiens<400>  55

Ser Tyr Ala Met Ser 
1               5   


<210>  56<211>  17<212>  PRT<213>  Homo sapiens<400>  56

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  57<211>  11<212>  PRT<213>  Homo sapiens<400>  57

Val Gly Ala Ala Gly Glu Gly Tyr Tyr Gly Tyr 
1               5                   10      


<210>  58<211>  13<212>  PRT<213>  Homo sapiens<400>  58

Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 
1               5                   10              


<210>  59<211>  7<212>  PRT<213>  Homo sapiens<400>  59

Asp Asp Asn Gln Arg Pro Ser 
1               5           


<210>  60<211>  9<212>  PRT<213>  Homo sapiens<400>  60

Gln Ser Tyr Asp Ser Asn Asn Asp Val 
1               5                   


<210>  61<211>  5<212>  PRT<213>  Homo sapiens<400>  61

Gln Thr Gly Val Ser 
1               5   


<210>  62<211>  17<212>  PRT<213>  Homo sapiens<400>  62

Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe Gln Gly 
1               5                   10                  15      


<210>  63<211>  13<212>  PRT<213>  Homo sapiens<400>  63

Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  64<211>  11<212>  PRT<213>  Homo sapiens<400>  64

Gly Gly Asn Ile Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  65<211>  7<212>  PRT<213>  Homo sapiens<400>  65

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  66<211>  11<212>  PRT<213>  Homo sapiens<400>  66

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      


<210>  67<211>  5<212>  PRT<213>  Homo sapiens<400>  67

Asn Thr Gly Ile Ser 
1               5   


<210>  68<211>  17<212>  PRT<213>  Homo sapiens<400>  68

Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe Gln Gly 
1               5                   10                  15      


<210>  69<211>  13<212>  PRT<213>  Homo sapiens<400>  69

Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  70<211>  11<212>  PRT<213>  Homo sapiens<400>  70

Gly Gly Asn Ile Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  71<211>  7<212>  PRT<213>  Homo sapiens<400>  71

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  72<211>  11<212>  PRT<213>  Homo sapiens<400>  72

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      


<210>  73<211>  5<212>  PRT<213>  Homo sapiens<400>  73

Asn Tyr Gly Leu Ser 
1               5   


<210>  74<211>  17<212>  PRT<213>  Homo sapiens<400>  74

Trp Ile Ser Gly Ser Asn Gly Tyr Thr Ser Tyr Gly Gln Glu Phe Gln Gly 
1               5                   10                  15      


<210>  75<211>  13<212>  PRT<213>  Homo sapiens<400>  75

Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  76<211>  11<212>  PRT<213>  Homo sapiens<400>  76

Gly Gly Asn Ile Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  77<211>  7<212>  PRT<213>  Homo sapiens<400>  77

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  78<211>  11<212>  PRT<213>  Homo sapiens<400>  78

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      


<210>  79<211>  5<212>  PRT<213>  Homo sapiens<400>  79

Asn Tyr Gly Leu Ser 
1               5   


<210>  80<211>  17
<212>  PRT<213>  Homo sapiens<400>  80

Trp Ile Asn Asp Ala Thr Gly Asp Thr Gln Tyr Gly Gln Glu Phe Gln Gly 
1               5                   10                  15      


<210>  81<211>  13<212>  PRT<213>  Homo sapiens<400>  81

Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  82<211>  11<212>  PRT<213>  Homo sapiens<400>  82

Gly Gly Asn Ile Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  83<211>  7<212>  PRT<213>  Homo sapiens<400>  83

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  84<211>  11<212>  PRT<213>  Homo sapiens<400>  84

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      


<210>  85<211>  5<212>  PRT<213>  Homo sapiens<400>  85

Asp Thr Gly Val Ser 
1               5   


<210>  86<211>  17<212>  PRT<213>  Homo sapiens<400>  86

Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe Gln Gly 
1               5                   10                  15      


<210>  87<211>  13<212>  PRT<213>  Homo sapiens<400>  87

Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  88<211>  11<212>  PRT<213>  Homo sapiens<400>  88

Gly Gly Asn Ile Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  89<211>  7<212>  PRT<213>  Homo sapiens<400>  89

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  90<211>  11<212>  PRT<213>  Homo sapiens<400>  90

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      


<210>  91<211>  5<212>  PRT<213>  Homo sapiens<400>  91

Asn Tyr Gly Leu Ser 
1               5   


<210>  92<211>  17<212>  PRT<213>  Homo sapiens<400>  92

Trp Ile Ala Thr Pro Asp Gly Gln Thr Ser Tyr Gly Gln Glu Phe Gln Gly 
1               5                   10                  15      


<210>  93<211>  13<212>  PRT<213>  Homo sapiens<400>  93

Asp Ser Asn Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  94<211>  11<212>  PRT<213>  Homo sapiens<400>  94

Gly Gly Asn Ile Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  95<211>  7<212>  PRT<213>  Homo sapiens<400>  95

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  96<211>  11<212>  PRT<213>  Homo sapiens<400>  96

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      


<210>  97<211>  5<212>  PRT<213>  Homo sapiens<400>  97

Asn Tyr Gly Leu Ser 
1               5   


<210>  98<211>  17<212>  PRT<213>  Homo sapiens<400>  98

Trp Ile Asn Tyr Asp Gly Gly Asn Thr Gln Tyr Gly Gln Glu Phe Gln Gly 
1               5                   10                  15      


<210>  99<211>  13<212>  PRT<213>  Homo sapiens<400>  99

Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  100<211>  11<212>  PRT<213>  Homo sapiens<400>  100

Gly Gly Asn Ile Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  101<211>  7<212>  PRT<213>  Homo sapiens<400>  101

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  102<211>  11<212>  PRT<213>  Homo sapiens<400>  102

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      


<210>  103<211>  5<212>  PRT<213>  Homo sapiens<400>  103

Asp Tyr Gly Leu Ser 
1               5   


<210>  104<211>  16<212>  PRT<213>  Homo sapiens<400>  104

Trp Arg Ile Asn Asp Gly Tyr Thr Ile Tyr Gly Gln Glu Phe Gln Gly 
1               5                   10                  15      


<210>  105<211>  13<212>  PRT<213>  Homo sapiens<400>  105

Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  106<211>  11<212>  PRT<213>  Homo sapiens<400>  106

Gly Gly Asn Ile Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  107<211>  7<212>  PRT<213>  Homo sapiens<400>  107

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  108<211>  11<212>  PRT<213>  Homo sapiens<400>  108

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      


<210>  109<211>  366<212>  DNA<213>  Homo sapiens<400>  109
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttaca aattatggtc tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcagcgcta ataatggcga cacaaattat    180

ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

agcagcaact gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  110<211>  327<212>  DNA<213>  Homo sapiens<400>  110
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggtaagac ggccaggatt     60

acctgtgggg gaaacaacat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  111<211>  366<212>  DNA<213>  Homo sapiens<400>  111
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttaca aattatggtc tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcagcgcta ataatggcga cacaaattat    180

ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

agcagcagct gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  112<211>  327<212>  DNA<213>  Homo sapiens<400>  112
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt     60

acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  113<211>  366<212>  DNA<213>  Homo sapiens<400>  113
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttaca aattatggtc tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atctccggct tgaacggcga gacattgtat    180

ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

agcagcagct gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  114<211>  327<212>  DNA<213>  Homo sapiens<400>  114
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt     60

acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  115<211>  366<212>  DNA<213>  Homo sapiens<400>  115
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttaca aattatggtc tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcgcaaccc cagacggcca gacaagctat    180

ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

aacagcagct gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  116<211>  327<212>  DNA<213>  Homo sapiens<400>  116
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt     60

acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  117<211>  366<212>  DNA<213>  Homo sapiens<400>  117
caagtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttgag cagaccggcg tctcctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcagcgcta ataatggcga cacaaattat    180

ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

agcagcagct gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  118<211>  327<212>  DNA<213>  Homo sapiens<400>  118
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt     60

acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  119<211>  366<212>  DNA<213>  Homo sapiens<400>  119
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttatc gacaccgggg tctcctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcagcgcta ataatggcga cacaaattat    180

ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

agcagcagct gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  120<211>  327<212>  DNA<213>  Homo sapiens<400>  120
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt     60

acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  121<211>  366<212>  DNA<213>  Homo sapiens<400>  121
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttaca aattatggtc tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcaactacg acggcggcaa cacacagtat    180

ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

agcagcagct gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  122<211>  327<212>  DNA<213>  Homo sapiens<400>  122
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt     60

acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  123<211>  366<212>  DNA<213>  Homo sapiens<400>  123
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttaca aattatggtc tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcagcggga gcaacggcta cacatcttat    180

ggacaggaat tccagggcag agtcaccatg accacagata cgtccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

agcagcagct gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  124<211>  327<212>  DNA<213>  Homo sapiens<400>  124
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt     60

acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  125<211>  366<212>  DNA<213>  Homo sapiens<400>  125
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttaca aattatggtc tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcaacgacg ccaccggcga cacacagtat    180

ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

agcagcagct gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  126<211>  327<212>  DNA<213>  Homo sapiens<400>  126
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt     60

acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  127<211>  366<212>  DNA<213>  Homo sapiens<400>  127
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttaca gattatggtc tcagctgggt gcgacaggcc    120

cctggacaag ggctagagtg gatgggatgg atccgcaaca tcgacggcta cacaatttat    180

ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

agcagcagct gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  128<211>  327<212>  DNA<213>  Homo sapiens<400>  128
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt     60

acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  129<211>  366<212>  DNA<213>  Homo sapiens<400>  129
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttaca aattatggtc tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcgacgacg acagcggcac gacaatatat    180

ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

agcagcagct gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  130<211>  327<212>  DNA<213>  Homo sapiens<400>  130
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt     60

acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  131<211>  366<212>  DNA<213>  Homo sapiens<400>  131
caagtgcagt tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttgcg aacaccggga tctcgtgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcagcgcta ataatggcga cacaaattat    180

ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac    240

atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc    300

agcagcagct gggcccgctg gtttttcgat ctctggggtc gggggacact ggtcaccgtc    360

tcctca                                                               366


<210>  132<211>  327<212>  DNA<213>  Homo sapiens<400>  132
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt     60

acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc    120

caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga    180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg    240

gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc    300

ggagggacca agctgaccgt cctaggt                                        327


<210>  133<211>  122<212>  PRT<213>  Homo sapiens<400>  133

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Asn Asn Gly Glu Thr Asn Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Glu Thr Pro Thr Asn Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Ser Ser Asn Trp Ala Arg Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  134<211>  109<212>  PRT<213>  Homo sapiens<400>  134

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Pro Cys Gly Gly Asn Asn Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ile Asp Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  135<211>  5<212>  PRT<213>  Homo sapiens<400>  135

Asn Tyr Gly Leu Ser 
1               5   


<210>  136<211>  17<212>  PRT<213>  Homo sapiens<400>  136

Trp Ile Ser Ala Asn Asn Gly Glu Thr Asn Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  137<211>  13<212>  PRT<213>  Homo sapiens<400>  137

Asp Ser Ser Ser Asn Trp Ala Arg Trp Tyr Phe Asp Leu 
1               5                   10              


<210>  138<211>  11<212>  PRT<213>  Homo sapiens<400>  138

Gly Gly Asn Asn Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  139<211>  7<212>  PRT<213>  Homo sapiens<400>  139

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  140<211>  11<212>  PRT<213>  Homo sapiens<400>  140

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      


<210>  141<211>  5<212>  PRT<213>  Homo sapiens<400>  141

Ser Tyr Ala Met Ser 
1               5   


<210>  142<211>  17<212>  PRT<213>  Homo sapiens<400>  142

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  143<211>  11<212>  PRT<213>  Homo sapiens<400>  143

Val Gly Ala Ala Gly Glu Gly Tyr Tyr Gly Tyr 
1               5                   10      


<210>  144<211>  13<212>  PRT<213>  Homo sapiens<400>  144

Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Glu 
1               5                   10              


<210>  145<211>  7<212>  PRT<213>  Homo sapiens<400>  145

Asp Asp Asn Gln Arg Pro Ser 
1               5           


<210>  146<211>  9<212>  PRT<213>  Homo sapiens<400>  146

Gln Ser Tyr Asp Ser Asn Asn Asp Val 
1               5                   


<210>  147<211>  5<212>  PRT<213>  Homo sapiens<400>  147

Ser Tyr Ala Met Ser 
1               5   


<210>  148<211>  17<212>  PRT<213>  Homo sapiens<400>  148

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  149<211>  13<212>  PRT<213>  Homo sapiens<400>  149

Val Gly Arg Ala Thr Thr Asp Glu Gly Tyr Tyr Gly Tyr 
1               5                   10              


<210>  150<211>  13<212>  PRT<213>  Homo sapiens<400>  150

Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 
1               5                   10              


<210>  151<211>  7<212>  PRT<213>  Homo sapiens<400>  151

Asp Asp Asn Gln Arg Pro Ser 
1               5           


<210>  152<211>  9<212>  PRT<213>  Homo sapiens<400>  152

Gln Ser Tyr Asp Ser Asn Asn Asp Val 
1               5                   


<210>  153<211>  5<212>  PRT<213>  Homo sapiens<400>  153

Ser Tyr Ala Met Ser 
1               5   


<210>  154<211>  17<212>  PRT<213>  Homo sapiens<400>  154

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  155<211>  11<212>  PRT<213>  Homo sapiens<400>  155

Val Gly Lys Ala Thr Thr Glu Glu Gly Tyr Tyr 
1               5                   10      


<210>  156<211>  13<212>  PRT<213>  Homo sapiens<400>  156

Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 
1               5                   10              


<210>  157<211>  7<212>  PRT<213>  Homo sapiens<400>  157

Asp Asp Asn Gln Arg Pro Ser 
1               5           


<210>  158<211>  9<212>  PRT<213>  Homo sapiens<400>  158

Gln Ser Tyr Asp Ser Asn Asn Asp Val 
1               5                   


<210>  159<211>  15<212>  DNA<213>  Homo sapiens<400>  159
aattatggtc tcagc                                                      15


<210>  160<211>  51<212>  DNA<213>  Homo sapiens<400>  160
tggatcagcg ctaataatgg cgacacaaat tatggacagg aattccaggg c              51


<210>  161<211>  39<212>  DNA<213>  Homo sapiens<400>  161
gactccagca gcaactgggc ccgctggttt ttcgatctc                            39


<210>  162<211>  33<212>  DNA<213>  Homo sapiens<400>  162
gggggaaaca acattggaag taaacttgta cac                                  33


<210>  163<211>  21<212>  DNA<213>  Homo sapiens<400>  163
gatgatggcg accggccctc a                                               21


<210>  164<211>  33<212>  DNA<213>  Homo sapiens<400>  164
caggtgtggg atactggtag tgatcccgtg gta                                  33


<210>  165<211>  15<212>  DNA<213>  Homo sapiens<400>  165
aattatggtc tcagc                                                      15


<210>  166<211>  51<212>  DNA<213>  Homo sapiens<400>  166
tggatcagcg ctaataatgg cgacacaaat tatggacagg aattccaggg c              51


<210>  167<211>  39<212>  DNA<213>  Homo sapiens<400>  167
gactccagca gcagctgggc ccgctggttt ttcgatctc                            39


<210>  168<211>  33<212>  DNA<213>  Homo sapiens<400>  168
gggggaaaca tcattggaag taaacttgta cac                                  33


<210>  169<211>  21<212>  DNA<213>  Homo sapiens<400>  169
gatgatggcg accggccctc a                                               21


<210>  170<211>  33<212>  DNA<213>  Homo sapiens<400>  170
caggtgtggg atactggtag tgatcccgtg gta                                  33


<210>  171<211>  327<212>  PRT<213>  Homo sapiens<400>  171

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  172<211>  105<212>  PRT<213>  Homo sapiens<400>  172

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  173<211>  132<212>  PRT<213>  Homo sapiens<400>  173

Met Ala Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Phe Ala Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu 
            20                  25                  30          


Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys 
        35                  40                  45              


Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys 
    50                  55                  60                  


Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu 
65                  70                  75                  80  


Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala 
                85                  90                  95      


Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala 
            100                 105                 110         


Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu 
        115                 120                 125             


Gly Arg Phe Asn 
    130         


<210>  174<211>  132<212>  PRT<213>  Macaca fascicularis<400>  174

Met Ala Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Phe Ala Ser Pro Ser Pro Val Pro Pro Ser Thr Ala Leu Lys Glu Leu 
            20                  25                  30          


Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys 
        35                  40                  45              


Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Val Tyr Cys 
    50                  55                  60                  


Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu 
65                  70                  75                  80  


Lys Thr Gln Arg Met Leu Asn Gly Phe Cys Pro His Lys Val Ser Ala 
                85                  90                  95      


Gly Gln Phe Ser Ser Leu Arg Val Arg Asp Thr Lys Ile Glu Val Ala 
            100                 105                 110         


Gln Phe Val Lys Asp Leu Leu Val His Leu Lys Lys Leu Phe Arg Glu 
        115                 120                 125             


Gly Gln Phe Asn 
    130         


<210>  175<211>  131<212>  PRT<213>  Mus sp.<400>  175

Met Ala Leu Trp Val Thr Ala Val Leu Ala Leu Ala Cys Leu Gly Gly 
1               5                   10                  15      


Leu Ala Ala Pro Gly Pro Val Pro Arg Ser Val Ser Leu Pro Leu Thr 
            20                  25                  30          


Leu Lys Glu Leu Ile Glu Glu Leu Ser Asn Ile Thr Gln Asp Gln Thr 
        35                  40                  45              


Pro Leu Cys Asn Gly Ser Met Val Trp Ser Val Asp Leu Ala Ala Gly 
    50                  55                  60                  


Gly Phe Cys Val Ala Leu Asp Ser Leu Thr Asn Ile Ser Asn Cys Asn 
65                  70                  75                  80  


Ala Ile Tyr Arg Thr Gln Arg Ile Leu His Gly Leu Cys Asn Arg Lys 
                85                  90                  95      


Ala Pro Thr Thr Val Ser Ser Leu Pro Asp Thr Lys Ile Glu Val Ala 
            100                 105                 110         


His Phe Ile Thr Lys Leu Leu Ser Tyr Thr Lys Gln Leu Phe Arg His 
        115                 120                 125             


Gly Pro Phe 
    130     


<210>  176<211>  5<212>  PRT<213>  Artificial sequence<220><223>  HCDR1 formula

<220><221>  MISC_FEATURE<222>  (1)..(1)<223>  Xaa is selected from the group consisting of Asn, Gln, Asp, Leu, 
       Gly and Glu

<220><221>  MISC_FEATURE<222>  (2)..(2)<223>  Xaa is selected from the group consisting of Tyr and Thr

<220><221>  MISC_FEATURE<222>  (4)..(4)<223>  Xaa is selected from the group consisting of Val, Ile, Phe and Le
       u

<400>  176

Xaa Xaa Gly Xaa Ser 
1               5   


<210>  177<211>  17<212>  PRT<213>  Artificial sequence<220><223>  HCDR2 formula

<220><221>  MISC_FEATURE<222>  (3)..(3)<223>  Xaa is selected from the group consisting of Ser, Asp, Asn, Ala, 
       Arg, Gly and Glu

<220><221>  MISC_FEATURE<222>  (4)..(4)<223>  Xaa is selected from the group consisting of Ala, Asp, Gly, Thr, 
       Pro, Asn and Tyr

<220><221>  MISC_FEATURE<222>  (5)..(5)<223>  Xaa is selected from the group consisting of Asn, Asp, Leu, Ala, 
       Pro, Thr, Ser, Ile and Arg

<220><221>  MISC_FEATURE<222>  (6)..(6)<223>  Xaa is selected from the group consisting of Asn, Ser, Thr, Asp, 
       Gly, Lys and Ile

<220><221>  MISC_FEATURE<222>  (8)..(8)<223>  Xaa is selected from the group consisting of Asp, Thr, Glu, Gln, 
       Leu, Tyr, Asn, Val, Ala, Met and Gly

<220><221>  MISC_FEATURE<222>  (10)..(10)<223>  Xaa is selected from the group consisting of Asn, Ile, Leu, Gln, 
       Ser, Met, His, Asp and Lys

<220><221>  MISC_FEATURE<222>  (12)..(12)<223>  Xaa is selected from the group consisting of Gly and Arg

<220><221>  MISC_FEATURE<222>  (13)..(13)<223>  Xaa is selected from the group consisting of Gln and Arg

<220><221>  MISC_FEATURE<222>  (14)..(14)<223>  Xaa is selected from the group consisting of Glu, Lys and Gly

<220><221>  MISC_FEATURE<222>  (16)..(16)<223>  Xaa is selected from the group consisting of Gln and Arg

<220><221>  MISC_FEATURE<222>  (17)..(17)<223>  Xaa is selected from the group consisting of Gly and Lys

<400>  177

Trp Ile Xaa Xaa Xaa Xaa Gly Xaa Thr Xaa Tyr Xaa Xaa Xaa Phe Xaa 
1               5                   10                  15      


Xaa 
    


<210>  178<211>  13<212>  PRT<213>  Artificial sequence<220><223>  HCDR3 formula

<220><221>  MISC_FEATURE<222>  (2)..(2)<223>  Xaa is selected from the group consisting of Ser, Arg and Asp

<220><221>  MISC_FEATURE<222>  (3)..(3)<223>  Xaa is selected from the group consisting of Ser, Asn, Asp, Thr a
       nd Pro

<220><221>  MISC_FEATURE<222>  (4)..(4)<223>  Xaa is selected from the group consisting of Ser and Arg

<220><221>  MISC_FEATURE<222>  (5)..(5)<223>  Xaa is selected from the group consisting of Ser, Asn, Ala, Ile, 
       Arg, Pro and Lys

<220><221>  MISC_FEATURE<222>  (10)..(10)<223>  Xaa is selected from the group consisting of Phe and Tyr

<220><221>  MISC_FEATURE<222>  (12)..(12)<223>  Xaa is selected from the group consisting of Asp and Tyr

<400>  178

Asp Xaa Xaa Xaa Xaa Trp Ala Arg Trp Xaa Phe Xaa Leu 
1               5                   10              


<210>  179<211>  11<212>  PRT<213>  Artificial sequence<220><223>  LCDR1 formula

<220><221>  MISC_FEATURE<222>  (3)..(3)<223>  Xaa is selected from the group consisting of Asn, Asp and Ser

<220><221>  MISC_FEATURE<222>  (4)..(4)<223>  Xaa is selected from the group consisting of Asn, Ile, Leu, Met, 
       Cys, Val, Lys, Tyr, Phe, Arg, Thr, Ser, Ala, His and Gly

<220><221>  MISC_FEATURE<222>  (5)..(5)<223>  Xaa is selected from the group consisting of Ile and Val

<220><221>  MISC_FEATURE<222>  (7)..(7)<223>  Xaa is selected from the group consisting of Ser and Gly

<220><221>  MISC_FEATURE<222>  (8)..(8)<223>  Xaa is selected from the group consisting of Lys and Arg

<400>  179

Gly Gly Xaa Xaa Xaa Gly Xaa Xaa Leu Val His 
1               5                   10      


<210>  180<211>  7<212>  PRT<213>  Artificial sequence<220><223>  LCDR2 formula

<220><221>  MISC_FEATURE<222>  (7)..(7)<223>  Xaa is selected from the group consisting of Ser and Thr

<400>  180

Asp Asp Gly Asp Arg Pro Xaa 
1               5           


<210>  181<211>  11<212>  PRT<213>  Artificial sequence<220><223>  LCDR3 formula

<220><221>  MISC_FEATURE<222>  (8)..(8)<223>  Xaa is selected from the group consisting of Asp and Asn

<220><221>  MISC_FEATURE<222>  (11)..(11)<223>  Xaa is selected from the group consisting of Val and Ile

<400>  181

Gln Val Trp Asp Thr Gly Ser Xaa Pro Val Xaa 
1               5                   10      


<210>  182<211>  5<212>  PRT<213>  Homo sapiens<400>  182

Leu Thr Gly Val Ser 
1               5   


<210>  183<211>  5<212>  PRT<213>  Homo sapiens<400>  183

Gly Thr Gly Val Ser 
1               5   


<210>  184<211>  5<212>  PRT<213>  Homo sapiens<400>  184

Glu Thr Gly Ile Ser 
1               5   


<210>  185<211>  5<212>  PRT<213>  Homo sapiens<400>  185

Asp Thr Gly Ile Ser 
1               5   


<210>  186<211>  5<212>  PRT<213>  Homo sapiens<400>  186

Gly Thr Gly Ile Ser 
1               5   


<210>  187<211>  5<212>  PRT<213>  Homo sapiens<400>  187

Asn Tyr Gly Phe Ser 
1               5   


<210>  188<211>  17<212>  PRT<213>  Homo sapiens<400>  188

Trp Ile Arg Pro Thr Asp Gly Leu Thr Met Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  189<211>  17<212>  PRT<213>  Homo sapiens<400>  189

Trp Ile Asp Asp Arg Thr Gly Thr Thr Gln Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  190<211>  17<212>  PRT<213>  Homo sapiens<400>  190

Trp Ile Arg Ala Ser Asp Gly Gln Thr Ile Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  191<211>  17<212>  PRT<213>  Homo sapiens<400>  191

Trp Ile Ser Gly Ile Asp Gly Val Thr Leu Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  192<211>  17<212>  PRT<213>  Homo sapiens<400>  192

Trp Ile Arg Ala Ala Asp Gly Glu Thr His Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  193<211>  17<212>  PRT<213>  Homo sapiens<400>  193

Trp Ile Gly Asn Asn Asn Gly Asp Thr Leu Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  194<211>  17<212>  PRT<213>  Homo sapiens<400>  194

Trp Ile Gly Pro Ser Lys Gly Glu Thr Ser Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  195<211>  17<212>  PRT<213>  Homo sapiens<400>  195

Trp Ile Arg Pro Arg Asp Gly Thr Thr His Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  196<211>  17<212>  PRT<213>  Homo sapiens<400>  196

Trp Ile Ser Gly Arg Ser Gly Ala Thr Leu Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  197<211>  17<212>  PRT<213>  Homo sapiens<400>  197

Trp Ile Glu Gly Ser Thr Gly Asn Thr Ile Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  198<211>  17<212>  PRT<213>  Homo sapiens<400>  198

Trp Ile Gly Pro Ile Asn Gly Met Thr His Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  199<211>  17<212>  PRT<213>  Homo sapiens<400>  199

Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  200<211>  17<212>  PRT<213>  Homo sapiens<400>  200

Trp Ile Ser Ala Asn Asn Gly Asp Thr Asp Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  201<211>  17<212>  PRT<213>  Homo sapiens<400>  201

Trp Ile Ser Ala Asn Asn Gly Gly Thr Asn Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  202<211>  17<212>  PRT<213>  Homo sapiens<400>  202

Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Arg Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  203<211>  17<212>  PRT<213>  Homo sapiens<400>  203

Trp Ile Gly Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  204<211>  17<212>  PRT<213>  Homo sapiens<400>  204

Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  205<211>  17<212>  PRT<213>  Homo sapiens<400>  205

Trp Ile Ser Ala Asn Asn Gly Asp Thr Ile Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  206<211>  17<212>  PRT<213>  Homo sapiens<400>  206

Trp Ile Ser Thr Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  207<211>  17<212>  PRT<213>  Homo sapiens<400>  207

Trp Ile Ser Ala Asn Asn Gly Asp Thr Ile Tyr Arg Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  208<211>  17<212>  PRT<213>  Homo sapiens<400>  208

Trp Ile Ser Ala Asn Asn Gly Asp Thr Ser Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  209<211>  17<212>  PRT<213>  Homo sapiens<400>  209

Trp Ile Ser Ala Asn Asn Gly Asp Thr Lys Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  210<211>  17<212>  PRT<213>  Homo sapiens<400>  210

Trp Ile Gly Ala Asn Asn Gly Asp Thr Asp Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  211<211>  17<212>  PRT<213>  Homo sapiens<400>  211

Trp Ile Ser Ala Asn Ile Gly Asp Thr Asn Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  212<211>  17<212>  PRT<213>  Homo sapiens<400>  212

Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Gly Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  213<211>  17<212>  PRT<213>  Homo sapiens<400>  213

Trp Ile Ser Thr Asn Asn Gly Asp Thr Asn Tyr Gly Arg Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  214<211>  17<212>  PRT<213>  Homo sapiens<400>  214

Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      


Lys 
    


<210>  215<211>  13<212>  PRT<213>  Homo sapiens<400>  215

Asp Ser Asp Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  216<211>  13<212>  PRT<213>  Homo sapiens<400>  216

Asp Ser Thr Ser Ala Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  217<211>  13<212>  PRT<213>  Homo sapiens<400>  217

Asp Ser Asn Ser Ala Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  218<211>  13<212>  PRT<213>  Homo sapiens<400>  218

Asp Ser Ser Ser Ile Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  219<211>  13<212>  PRT<213>  Homo sapiens<400>  219

Asp Ser Thr Ser Arg Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  220<211>  13<212>  PRT<213>  Homo sapiens<400>  220

Asp Asp Pro Arg Pro Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  221<211>  13<212>  PRT<213>  Homo sapiens<400>  221

Asp Ser Ser Ser Lys Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  222<211>  13<212>  PRT<213>  Homo sapiens<400>  222

Asp Ser Asn Ser Asn Trp Ala Arg Trp Phe Phe Tyr Leu 
1               5                   10              


<210>  223<211>  13<212>  PRT<213>  Homo sapiens<400>  223

Asp Ser Asn Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  224<211>  13<212>  PRT<213>  Homo sapiens<400>  224

Asp Arg Asp Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              


<210>  225<211>  11<212>  PRT<213>  Homo sapiens<400>  225

Gly Gly Asn Leu Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  226<211>  11<212>  PRT<213>  Homo sapiens<400>  226

Gly Gly Asn Met Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  227<211>  11<212>  PRT<213>  Homo sapiens<400>  227

Gly Gly Asn Cys Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  228<211>  11<212>  PRT<213>  Homo sapiens<400>  228

Gly Gly Asn Val Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  229<211>  11<212>  PRT<213>  Homo sapiens<400>  229

Gly Gly Asn Lys Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  230<211>  11<212>  PRT<213>  Homo sapiens<400>  230

Gly Gly Asn Tyr Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  231<211>  11<212>  PRT<213>  Homo sapiens<400>  231

Gly Gly Asn Phe Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  232<211>  11<212>  PRT<213>  Homo sapiens<400>  232

Gly Gly Asn Arg Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  233<211>  11<212>  PRT<213>  Homo sapiens<400>  233

Gly Gly Asn Thr Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  234<211>  11<212>  PRT<213>  Homo sapiens<400>  234

Gly Gly Asn Asn Ile Gly Gly Lys Leu Val His 
1               5                   10      


<210>  235<211>  11<212>  PRT<213>  Homo sapiens<400>  235

Gly Gly Asn Ser Ile Gly Ser Arg Leu Val His 
1               5                   10      


<210>  236<211>  11<212>  PRT<213>  Homo sapiens<400>  236

Gly Gly Asp Asn Ile Gly Gly Lys Leu Val His 
1               5                   10      


<210>  237<211>  11<212>  PRT<213>  Homo sapiens<400>  237

Gly Gly Asn Ser Ile Gly Gly Lys Leu Val His 
1               5                   10      


<210>  238<211>  11<212>  PRT<213>  Homo sapiens<400>  238

Gly Gly Asn Ala Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  239<211>  11<212>  PRT<213>  Homo sapiens<400>  239

Gly Gly Asn Ser Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  240<211>  11<212>  PRT<213>  Homo sapiens<400>  240

Gly Gly Asn His Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  241<211>  11<212>  PRT<213>  Homo sapiens<400>  241

Gly Gly Asn Gly Ile Gly Ser Lys Leu Val His 
1               5                   10      


<210>  242<211>  11<212>  PRT<213>  Homo sapiens<400>  242

Gly Gly Ser Asn Ile Gly Gly Lys Leu Val His 
1               5                   10      


<210>  243<211>  11<212>  PRT<213>  Homo sapiens<400>  243

Gly Gly Asn Asn Val Gly Gly Lys Leu Val His 
1               5                   10      


<210>  244<211>  11<212>  PRT<213>  Homo sapiens<400>  244

Gly Gly Asn Asn Ile Gly Ser Arg Leu Val His 
1               5                   10      


<210>  245<211>  7<212>  PRT<213>  Homo sapiens<400>  245

Asp Asp Gly Asp Arg Pro Thr 
1               5           


<210>  246<211>  11<212>  PRT<213>  Homo sapiens<400>  246

Gln Val Trp Asp Thr Gly Ser Asn Pro Val Val 
1               5                   10      


<210>  247<211>  11<212>  PRT<213>  Homo sapiens<400>  247

Gln Val Trp Asp Thr Gly Ser Asp Pro Val Ile 
1               5                   10      


<210>  248<211>  132<212>  PRT<213>  Artificial sequence<220><223>  Consensus between human IL-3 and Cynomolgus IL-3

<220><221>  MISC_FEATURE<222>  (21, 30, 62, 87, 103, 120, 130)<223>  Xaa = no consensus

<400>  248

Met Ala Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly 
1               5                   10                  15      


Phe Ala Ser Pro Xaa Pro Val Pro Pro Ser Thr Ala Leu Xaa Glu Leu 
            20                  25                  30          


Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys 
        35                  40                  45              


Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Xaa Tyr Cys 
    50                  55                  60                  


Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu 
65                  70                  75                  80  


Lys Thr Gln Arg Met Leu Xaa Gly Phe Cys Pro His Lys Val Ser Ala 
                85                  90                  95      


Gly Gln Phe Ser Ser Leu Xaa Val Arg Asp Thr Lys Ile Glu Val Ala 
            100                 105                 110         


Gln Phe Val Lys Asp Leu Leu Xaa His Leu Lys Lys Leu Phe Arg Glu 
        115                 120                 125             


Gly Xaa Phe Asn 
    130         


<210>  249<211>  136<212>  PRT<213>  Artificial sequence<220><223>  Consensus between human IL-3 and murine IL-3

<220><221>  MISC_FEATURE<222>  (4, 5, 7, 9, 12, 17, 19, 25, 27..32, 34, 41, 46, 48)<223>  Xaa = no consensus

<220><221>  MISC_FEATURE<222>  (49, 60, 61, 63, 66, 67, 69, 72, 75, 77, 79, 81, 84)<223>  Xaa = no consensus

<220><221>  MISC_FEATURE<222>  (85, 89, 91, 93, 95, 96, 98..103, 107..109, 117)<223>  Xaa = no consensus

<220><221>  MISC_FEATURE<222>  (119..121, 124..126, 128, 132, 134, 136)<223>  Xaa = no consensus

<400>  249

Met Ala Leu Xaa Xaa Thr Xaa Val Xaa Ala Leu Xaa Cys Leu Gly Gly 
1               5                   10                  15      


Xaa Ala Xaa Pro Gly Pro Val Pro Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Leu Xaa Glu Leu Ile Glu Glu Leu Xaa Asn Ile Thr Gln Xaa Gln Xaa 
        35                  40                  45              


Xaa Pro Leu Cys Asn Gly Ser Met Val Trp Ser Xaa Xaa Leu Xaa Ala 
    50                  55                  60                  


Gly Xaa Xaa Cys Xaa Ala Leu Xaa Ser Leu Xaa Asn Xaa Ser Xaa Cys 
65                  70                  75                  80  


Xaa Ala Ile Xaa Xaa Thr Gln Arg Xaa Leu Xaa Gly Xaa Cys Xaa Xaa 
                85                  90                  95      


Lys Xaa Xaa Xaa Xaa Xaa Xaa Ser Ser Leu Xaa Xaa Xaa Asp Thr Lys 
            100                 105                 110         


Ile Glu Val Ala Xaa Phe Xaa Xaa Xaa Leu Leu Xaa Xaa Xaa Lys Xaa 
        115                 120                 125             


Leu Phe Arg Xaa Gly Xaa Phe Xaa 
    130                 135     





73

