                         SEQUENCE LISTING

<110>  D'Angelo, Marina
       Selim, Abdulhafez A.
 
<120>  COMPOSITIONS AND METHODS FOR INHIBITION OF MMP:MMP-SUBSTRATE 
       INTERACTIONS

<130>  P224717.WO.01

<160>  151   

<170>  PatentIn version 3.5

<210>  1
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Pro Asp Lys Cys Asp Pro Ser Leu Ser Leu Asp Ala Ile Thr Ser 
1               5                   10                  15      


Leu Arg Gly Glu Thr Met Ile Phe Lys Asp Arg Phe Phe Trp Arg Leu 
            20                  25                  30          


His Pro Gln Gln Val Asp Ala Glu Leu Phe Leu Thr Lys Ser Phe Trp 
        35                  40                  45              


Pro Glu Leu Pro Asn Arg Ile Asp Ala Ala Tyr Glu His Pro Ser His 
    50                  55                  60                  


Asp Leu Ile Phe Ile Phe Arg Gly Arg Lys Phe Trp Ala Leu Asn Gly 
65                  70                  75                  80  


Tyr Asp Ile Leu Glu Gly Tyr Pro Lys Lys Ile Ser Glu Leu Gly Leu 
                85                  90                  95      


Pro Lys Glu Val Lys Lys Ile Ser Ala Ala Val His Phe Glu Asp Thr 
            100                 105                 110         


Gly Lys Thr Leu Leu Phe Ser Gly Asn Gln Val Trp Arg Tyr Asp Asp 
        115                 120                 125             


Thr Asn His Ile Met Asp Lys Asp Tyr Pro Arg Leu Ile Glu Glu Asp 
    130                 135                 140                 


Phe Pro Gly Ile Gly Asp Lys Val Asp Ala Val Tyr Glu Lys Asn Gly 
145                 150                 155                 160 


Tyr Ile Tyr Phe Phe Asn Gly Pro Ile Gln Phe Glu Tyr Ser Ile Trp 
                165                 170                 175     


Ser Asn Arg Ile Val Arg Val Met Pro Ala Asn Ser Ile Leu Trp Cys 
            180                 185                 190         


<210>  2
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Pro Ala Pro Arg Pro Ser Arg Cys Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser 
            20                  25                  30          


Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly 
        35                  40                  45              


Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala 
    50                  55                  60                  


Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala 
65                  70                  75                  80  


Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro 
                85                  90                  95      


Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr 
            100                 105                 110         


Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile 
        115                 120                 125             


Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile 
    130                 135                 140                 


Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg 
145                 150                 155                 160 


Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp 
                165                 170                 175     


Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe 
            180                 185                 190         


Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn 
        195                 200                 205             


Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg 
    210                 215                 220                 


Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu 
225                 230                 235                 240 


Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile 
                245                 250                 255     


Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro 
            260                 265                 270         


Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly 
        275                 280                 285             


Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser 
    290                 295                 300                 


Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp 
305                 310                 315                 320 


Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe 
                325                 330                 335     


Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly 
            340                 345                 350         


Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile 
        355                 360                 365             


Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly 
    370                 375                 380                 


Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro 
385                 390                 395                 400 


Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp 
                405                 410                 415     


Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly 
            420                 425                 430         


Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu 
        435                 440                 445             


Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg 
    450                 455                 460                 


Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly 
465                 470                 475                 480 


Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly 
                485                 490                 495     


Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly 
            500                 505                 510         


Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu 
        515                 520                 525             


Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val Leu 
    530                 535                 540                 


Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe 
545                 550                 555                 560 


Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln Arg 
                565                 570                 575     


Ser Leu Leu Asp Lys Val 
            580         


<210>  3
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His 
1               5                   10                  15      


His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala 
            20                  25                  30          


Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln 
        35                  40                  45              


Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg 
    50                  55                  60                  


Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr 
65                  70                  75                  80  


Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met 
                85                  90                  95      


Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys 
            100                 105                 110         


Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln 
        115                 120                 125             


His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly 
    130                 135                 140                 


Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln 
145                 150                 155                 160 


Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu 
                165                 170                 175     


Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe 
            180                 185                 190         


His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His 
        195                 200                 205             


Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser 
    210                 215                 220                 


Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu 
225                 230                 235                 240 


Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His 
                245                 250                 255     


Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu 
            260                 265                 270         


Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys 
        275                 280                 285             


Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro 
    290                 295                 300                 


Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn 
305                 310                 315                 320 


Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro 
                325                 330                 335     


Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile 
            340                 345                 350         


Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val 
        355                 360                 365             


Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe 
    370                 375                 380                 


Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp 
385                 390                 395                 400 


Gly Asn Phe Val Phe Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp 
                405                 410                 415     


Thr Thr Leu Gln Pro Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Ser 
            420                 425                 430         


Gly Ile Pro Pro His Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val 
        435                 440                 445             


Gly Lys Thr Tyr Phe Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu 
    450                 455                 460                 


Glu Met Lys Thr Met Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp 
465                 470                 475                 480 


Lys Gly Ile Pro Glu Ser Pro Gln Gly Ala Phe Val His Lys Glu Asn 
                485                 490                 495     


Gly Phe Thr Tyr Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn 
            500                 505                 510         


Gln Ile Leu Lys Val Glu Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp 
        515                 520                 525             


Phe Met Gly Cys Asp Gly Pro Thr Asp Arg Val Lys Glu Gly His Ser 
    530                 535                 540                 


Pro Pro Asp Asp Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser 
545                 550                 555                 560 


Thr Val Lys Ala Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys 
                565                 570                 575     


Leu Leu Val Leu Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr 
            580                 585                 590         


Pro Arg His Ile Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val 
        595                 600                 605         


<210>  4
<211>  660
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Ala Leu Met Ala Arg Gly Ala Leu Thr Gly Pro Leu Arg Ala 
1               5                   10                  15      


Leu Cys Leu Leu Gly Cys Leu Leu Ser His Ala Ala Ala Ala Pro Ser 
            20                  25                  30          


Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys Thr Asp Lys Glu 
        35                  40                  45              


Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser 
    50                  55                  60                  


Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe 
65                  70                  75                  80  


Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr 
                85                  90                  95      


Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe 
            100                 105                 110         


Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile 
        115                 120                 125             


Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe 
    130                 135                 140                 


Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser 
145                 150                 155                 160 


Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp 
                165                 170                 175     


Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala 
            180                 185                 190         


His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp 
        195                 200                 205             


Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys 
    210                 215                 220                 


Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe 
                245                 250                 255     


Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly 
            260                 265                 270         


Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly 
        275                 280                 285             


Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser 
    290                 295                 300                 


Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr 
305                 310                 315                 320 


Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala 
                325                 330                 335     


Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro 
            340                 345                 350         


Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg 
        355                 360                 365             


Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp 
    370                 375                 380                 


Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val 
385                 390                 395                 400 


Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp 
                405                 410                 415     


Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg 
            420                 425                 430         


Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser 
        435                 440                 445             


Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val 
    450                 455                 460                 


Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln 
465                 470                 475                 480 


Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr 
                485                 490                 495     


Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe 
            500                 505                 510         


Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln 
        515                 520                 525             


Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser 
    530                 535                 540                 


Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly 
545                 550                 555                 560 


Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys 
                565                 570                 575     


Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn 
            580                 585                 590         


Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp 
        595                 600                 605             


Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln 
    610                 615                 620                 


Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu 
625                 630                 635                 640 


Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp 
                645                 650                 655     


Trp Leu Gly Cys 
            660 


<210>  5
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 
    50                  55                  60                  


Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 
        275                 280                 285             


Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 
                325                 330                 335     


Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 
            340                 345                 350         


Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 
    450                 455                 460                 


Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 
465                 470                 475                 480 


Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 
                485                 490                 495     


Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 
            500                 505                 510         


Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 
        515                 520                 525             


Pro Ala Gly Glu Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp 
    530                 535                 540                 


Arg Phe Ser Glu Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile 
545                 550                 555                 560 


Ala Asp Lys Trp Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu 
                565                 570                 575     


Glu Arg Leu Ser Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp 
            580                 585                 590         


Val Tyr Thr Gly Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu 
        595                 600                 605             


Gly Leu Gly Ala Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly 
    610                 615                 620                 


Arg Gly Lys Met Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp 
625                 630                 635                 640 


Val Lys Ala Gln Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg 
                645                 650                 655     


Met Phe Pro Gly Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg 
            660                 665                 670         


Glu Lys Ala Tyr Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser 
        675                 680                 685             


Arg Ser Glu Leu Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp 
    690                 695                 700                 


Ile Leu Gln Cys Pro Glu Asp 
705                 710     


<210>  6
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn Cys Gln Gln Leu Trp Leu Gly Phe Leu Leu Pro Met Thr Val 
1               5                   10                  15      


Ser Gly Arg Val Leu Gly Leu Ala Glu Val Ala Pro Val Asp Tyr Leu 
            20                  25                  30          


Ser Gln Tyr Gly Tyr Leu Gln Lys Pro Leu Glu Gly Ser Asn Asn Phe 
        35                  40                  45              


Lys Pro Glu Asp Ile Thr Glu Ala Leu Arg Ala Phe Gln Glu Ala Ser 
    50                  55                  60                  


Glu Leu Pro Val Ser Gly Gln Leu Asp Asp Ala Thr Arg Ala Arg Met 
65                  70                  75                  80  


Arg Gln Pro Arg Cys Gly Leu Glu Asp Pro Phe Asn Gln Lys Thr Leu 
                85                  90                  95      


Lys Tyr Leu Leu Leu Gly Arg Trp Arg Lys Lys His Leu Thr Phe Arg 
            100                 105                 110         


Ile Leu Asn Leu Pro Ser Thr Leu Pro Pro His Thr Ala Arg Ala Ala 
        115                 120                 125             


Leu Arg Gln Ala Phe Gln Asp Trp Ser Asn Val Ala Pro Leu Thr Phe 
    130                 135                 140                 


Gln Glu Val Gln Ala Gly Ala Ala Asp Ile Arg Leu Ser Phe His Gly 
145                 150                 155                 160 


Arg Gln Ser Ser Tyr Cys Ser Asn Thr Phe Asp Gly Pro Gly Arg Val 
                165                 170                 175     


Leu Ala His Ala Asp Ile Pro Glu Leu Gly Ser Val His Phe Asp Glu 
            180                 185                 190         


Asp Glu Phe Trp Thr Glu Gly Thr Tyr Arg Gly Val Asn Leu Arg Ile 
        195                 200                 205             


Ile Ala Ala His Glu Val Gly His Ala Leu Gly Leu Gly His Ser Arg 
    210                 215                 220                 


Tyr Ser Gln Ala Leu Met Ala Pro Val Tyr Glu Gly Tyr Arg Pro His 
225                 230                 235                 240 


Phe Lys Leu His Pro Asp Asp Val Ala Gly Ile Gln Ala Leu Tyr Gly 
                245                 250                 255     


Lys Lys Ser Pro Val Ile Arg Asp Glu Glu Glu Glu Glu Thr Glu Leu 
            260                 265                 270         


Pro Thr Val Pro Pro Val Pro Thr Glu Pro Ser Pro Met Pro Asp Pro 
        275                 280                 285             


Cys Ser Ser Glu Leu Asp Ala Met Met Leu Gly Pro Arg Gly Lys Thr 
    290                 295                 300                 


Tyr Ala Phe Lys Gly Asp Tyr Val Trp Thr Val Ser Asp Ser Gly Pro 
305                 310                 315                 320 


Gly Pro Leu Phe Arg Val Ser Ala Leu Trp Glu Gly Leu Pro Gly Asn 
                325                 330                 335     


Leu Asp Ala Ala Val Tyr Ser Pro Arg Thr Gln Trp Ile His Phe Phe 
            340                 345                 350         


Lys Gly Asp Lys Val Trp Arg Tyr Ile Asn Phe Lys Met Ser Pro Gly 
        355                 360                 365             


Phe Pro Lys Lys Leu Asn Arg Val Glu Pro Asn Leu Asp Ala Ala Leu 
    370                 375                 380                 


Tyr Trp Pro Leu Asn Gln Lys Val Phe Leu Phe Lys Gly Ser Gly Tyr 
385                 390                 395                 400 


Trp Gln Trp Asp Glu Leu Ala Arg Thr Asp Phe Ser Ser Tyr Pro Lys 
                405                 410                 415     


Pro Ile Lys Gly Leu Phe Thr Gly Val Pro Asn Gln Pro Ser Ala Ala 
            420                 425                 430         


Met Ser Trp Gln Asp Gly Arg Val Tyr Phe Phe Lys Gly Lys Val Tyr 
        435                 440                 445             


Trp Arg Leu Asn Gln Gln Leu Arg Val Glu Lys Gly Tyr Pro Arg Asn 
    450                 455                 460                 


Ile Ser His Asn Trp Met His Cys Arg Pro Arg Thr Ile Asp Thr Thr 
465                 470                 475                 480 


Pro Ser Gly Gly Asn Thr Thr Pro Ser Gly Thr Gly Ile Thr Leu Asp 
                485                 490                 495     


Thr Thr Leu Ser Ala Thr Glu Thr Thr Phe Glu Tyr 
            500                 505             


<210>  7
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Arg Arg Ala Ala Arg Gly Pro Gly Pro Pro Pro Pro Gly Pro 
1               5                   10                  15      


Gly Leu Ser Arg Leu Pro Leu Pro Leu Leu Leu Leu Leu Ala Leu Gly 
            20                  25                  30          


Thr Arg Gly Gly Cys Ala Ala Pro Ala Pro Ala Pro Arg Ala Glu Asp 
        35                  40                  45              


Leu Ser Leu Gly Val Glu Trp Leu Ser Arg Phe Gly Tyr Leu Pro Pro 
    50                  55                  60                  


Ala Asp Pro Thr Thr Gly Gln Leu Gln Thr Gln Glu Glu Leu Ser Lys 
65                  70                  75                  80  


Ala Ile Thr Ala Met Gln Gln Phe Gly Gly Leu Glu Ala Thr Gly Ile 
                85                  90                  95      


Leu Asp Glu Ala Thr Leu Ala Leu Met Lys Thr Pro Arg Cys Ser Leu 
            100                 105                 110         


Pro Asp Leu Pro Val Leu Thr Gln Ala Arg Arg Arg Arg Gln Ala Pro 
        115                 120                 125             


Ala Pro Thr Lys Trp Asn Lys Arg Asn Leu Ser Trp Arg Val Arg Thr 
    130                 135                 140                 


Phe Pro Arg Asp Ser Pro Leu Gly His Asp Thr Val Arg Ala Leu Met 
145                 150                 155                 160 


Tyr Tyr Ala Leu Lys Val Trp Ser Asp Ile Ala Pro Leu Asn Phe His 
                165                 170                 175     


Glu Val Ala Gly Ser Ala Ala Asp Ile Gln Ile Asp Phe Ser Lys Ala 
            180                 185                 190         


Asp His Asn Asp Gly Tyr Pro Phe Asp Gly Pro Gly Gly Thr Val Ala 
        195                 200                 205             


His Ala Phe Phe Pro Gly His His His Thr Ala Gly Asp Thr His Phe 
    210                 215                 220                 


Asp Asp Asp Glu Ala Trp Thr Phe Arg Ser Ser Asp Ala His Gly Met 
225                 230                 235                 240 


Asp Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala Ile Gly Leu 
                245                 250                 255     


Ser His Val Ala Ala Ala His Ser Ile Met Arg Pro Tyr Tyr Gln Gly 
            260                 265                 270         


Pro Val Gly Asp Pro Leu Arg Tyr Gly Leu Pro Tyr Glu Asp Lys Val 
        275                 280                 285             


Arg Val Trp Gln Leu Tyr Gly Val Arg Glu Ser Val Ser Pro Thr Ala 
    290                 295                 300                 


Gln Pro Glu Glu Pro Pro Leu Leu Pro Glu Pro Pro Asp Asn Arg Ser 
305                 310                 315                 320 


Ser Ala Pro Pro Arg Lys Asp Val Pro His Arg Cys Ser Thr His Phe 
                325                 330                 335     


Asp Ala Val Ala Gln Ile Arg Gly Glu Ala Phe Phe Phe Lys Gly Lys 
            340                 345                 350         


Tyr Phe Trp Arg Leu Thr Arg Asp Arg His Leu Val Ser Leu Gln Pro 
        355                 360                 365             


Ala Gln Met His Arg Phe Trp Arg Gly Leu Pro Leu His Leu Asp Ser 
    370                 375                 380                 


Val Asp Ala Val Tyr Glu Arg Thr Ser Asp His Lys Ile Val Phe Phe 
385                 390                 395                 400 


Lys Gly Asp Arg Tyr Trp Val Phe Lys Asp Asn Asn Val Glu Glu Gly 
                405                 410                 415     


Tyr Pro Arg Pro Val Ser Asp Phe Ser Leu Pro Pro Gly Gly Ile Asp 
            420                 425                 430         


Ala Ala Phe Ser Trp Ala His Asn Asp Arg Thr Tyr Phe Phe Lys Asp 
        435                 440                 445             


Gln Leu Tyr Trp Arg Tyr Asp Asp His Thr Arg His Met Asp Pro Gly 
    450                 455                 460                 


Tyr Pro Ala Gln Ser Pro Leu Trp Arg Gly Val Pro Ser Thr Leu Asp 
465                 470                 475                 480 


Asp Ala Met Arg Trp Ser Asp Gly Ala Ser Tyr Phe Phe Arg Gly Gln 
                485                 490                 495     


Glu Tyr Trp Lys Val Leu Asp Gly Glu Leu Glu Val Ala Pro Gly Tyr 
            500                 505                 510         


Pro Gln Ser Thr Ala Arg Asp Trp Leu Val Cys Gly Asp Ser Gln Ala 
        515                 520                 525             


Asp Gly Ser Val Ala Ala Gly Val Asp Ala Ala Glu Gly Pro Arg Ala 
    530                 535                 540                 


Pro Pro Gly Gly Gln His Asp Gln Ser Arg Ser Glu Asp Gly Tyr Glu 
545                 550                 555                 560 


Val Cys Ser Cys Thr Ser Gly Ala Ser Ser Pro Pro Gly Ala Pro Gly 
                565                 570                 575     


Pro Leu Val Ala Ala Thr Met Leu Leu Leu Leu Pro Pro Leu Ser Pro 
            580                 585                 590         


Gly Ala Leu Trp Thr Ala Ala Gln Ala Leu Thr Leu 
        595                 600                 


<210>  8
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Ser Asp Pro Ser Ala Pro Gly Arg Pro Gly Trp Thr Gly Ser 
1               5                   10                  15      


Leu Leu Gly Asp Arg Glu Glu Ala Ala Arg Pro Arg Leu Leu Pro Leu 
            20                  25                  30          


Leu Leu Val Leu Leu Gly Cys Leu Gly Leu Gly Val Ala Ala Glu Asp 
        35                  40                  45              


Ala Glu Val His Ala Glu Asn Trp Leu Arg Leu Tyr Gly Tyr Leu Pro 
    50                  55                  60                  


Gln Pro Ser Arg His Met Ser Thr Met Arg Ser Ala Gln Ile Leu Ala 
65                  70                  75                  80  


Ser Ala Leu Ala Glu Met Gln Arg Phe Tyr Gly Ile Pro Val Thr Gly 
                85                  90                  95      


Val Leu Asp Glu Glu Thr Lys Glu Trp Met Lys Arg Pro Arg Cys Gly 
            100                 105                 110         


Val Pro Asp Gln Phe Gly Val Arg Val Lys Ala Asn Leu Arg Arg Arg 
        115                 120                 125             


Arg Lys Arg Tyr Ala Leu Thr Gly Arg Lys Trp Asn Asn His His Leu 
    130                 135                 140                 


Thr Phe Ser Ile Gln Asn Tyr Thr Glu Lys Leu Gly Trp Tyr His Ser 
145                 150                 155                 160 


Met Glu Ala Val Arg Arg Ala Phe Arg Val Trp Glu Gln Ala Thr Pro 
                165                 170                 175     


Leu Val Phe Gln Glu Val Pro Tyr Glu Asp Ile Arg Leu Arg Arg Gln 
            180                 185                 190         


Lys Glu Ala Asp Ile Met Val Leu Phe Ala Ser Gly Phe His Gly Asp 
        195                 200                 205             


Ser Ser Pro Phe Asp Gly Thr Gly Gly Phe Leu Ala His Ala Tyr Phe 
    210                 215                 220                 


Pro Gly Pro Gly Leu Gly Gly Asp Thr His Phe Asp Ala Asp Glu Pro 
225                 230                 235                 240 


Trp Thr Phe Ser Ser Thr Asp Leu His Gly Asn Asn Leu Phe Leu Val 
                245                 250                 255     


Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asn 
            260                 265                 270         


Pro Asn Ala Ile Met Ala Pro Phe Tyr Gln Trp Lys Asp Val Asp Asn 
        275                 280                 285             


Phe Lys Leu Pro Glu Asp Asp Leu Arg Gly Ile Gln Gln Leu Tyr Gly 
    290                 295                 300                 


Thr Pro Asp Gly Gln Pro Gln Pro Thr Gln Pro Leu Pro Thr Val Thr 
305                 310                 315                 320 


Pro Arg Arg Pro Gly Arg Pro Asp His Arg Pro Pro Arg Pro Pro Gln 
                325                 330                 335     


Pro Pro Pro Pro Gly Gly Lys Pro Glu Arg Pro Pro Lys Pro Gly Pro 
            340                 345                 350         


Pro Val Gln Pro Arg Ala Thr Glu Arg Pro Asp Gln Tyr Gly Pro Asn 
        355                 360                 365             


Ile Cys Asp Gly Asp Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met 
    370                 375                 380                 


Phe Val Phe Lys Gly Arg Trp Phe Trp Arg Val Arg His Asn Arg Val 
385                 390                 395                 400 


Leu Asp Asn Tyr Pro Met Pro Ile Gly His Phe Trp Arg Gly Leu Pro 
                405                 410                 415     


Gly Asp Ile Ser Ala Ala Tyr Glu Arg Gln Asp Gly Arg Phe Val Phe 
            420                 425                 430         


Phe Lys Gly Asp Arg Tyr Trp Leu Phe Arg Glu Ala Asn Leu Glu Pro 
        435                 440                 445             


Gly Tyr Pro Gln Pro Leu Thr Ser Tyr Gly Leu Gly Ile Pro Tyr Asp 
    450                 455                 460                 


Arg Ile Asp Thr Ala Ile Trp Trp Glu Pro Thr Gly His Thr Phe Phe 
465                 470                 475                 480 


Phe Gln Glu Asp Arg Tyr Trp Arg Phe Asn Glu Glu Thr Gln Arg Gly 
                485                 490                 495     


Asp Pro Gly Tyr Pro Lys Pro Ile Ser Val Trp Gln Gly Ile Pro Ala 
            500                 505                 510         


Ser Pro Lys Gly Ala Phe Leu Ser Asn Asp Ala Ala Tyr Thr Tyr Phe 
        515                 520                 525             


Tyr Lys Gly Thr Lys Tyr Trp Lys Phe Asp Asn Glu Arg Leu Arg Met 
    530                 535                 540                 


Glu Pro Gly Tyr Pro Lys Ser Ile Leu Arg Asp Phe Met Gly Cys Gln 
545                 550                 555                 560 


Glu His Val Glu Pro Gly Pro Arg Trp Pro Asp Val Ala Arg Pro Pro 
                565                 570                 575     


Phe Asn Pro His Gly Gly Ala Glu Pro Gly Ala Asp Ser Ala Glu Gly 
            580                 585                 590         


Asp Val Gly Asp Gly Asp Gly Asp Phe Gly Ala Gly Val Asn Lys Asp 
        595                 600                 605             


Gly Gly Ser Arg Val Val Val Gln Met Glu Glu Val Ala Arg Thr Val 
    610                 615                 620                 


Asn Val Val Met Val Leu Val Pro Leu Leu Leu Leu Leu Cys Val Leu 
625                 630                 635                 640 


Gly Leu Thr Tyr Ala Leu Val Gln Met Gln Arg Lys Gly Ala Pro Arg 
                645                 650                 655     


Val Leu Leu Tyr Cys Lys Arg Ser Leu Gln Glu Trp Val 
            660                 665                 


<210>  9
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Val Leu Pro Ala Ser Gly Leu Ala Val Phe Leu Ile Met Ala 
1               5                   10                  15      


Leu Thr Phe Ser Thr Ala Ala Pro Ser Leu Val Ala Ala Ser Pro Arg 
            20                  25                  30          


Thr Trp Arg Asn Asn Tyr Arg Leu Ala Gln Ala Tyr Leu Asp Lys Tyr 
        35                  40                  45              


Tyr Thr Asn Lys Glu Gly His Gln Ile Gly Glu Met Val Ala Arg Gly 
    50                  55                  60                  


Ser Asn Ser Met Ile Arg Lys Ile Lys Glu Leu Gln Ala Phe Phe Gly 
65                  70                  75                  80  


Leu Gln Val Thr Gly Lys Leu Asp Gln Thr Thr Met Asn Val Ile Lys 
                85                  90                  95      


Lys Pro Arg Cys Gly Val Pro Asp Val Ala Asn Tyr Arg Leu Phe Pro 
            100                 105                 110         


Gly Glu Pro Lys Trp Lys Lys Asn Thr Leu Thr Tyr Arg Ile Ser Lys 
        115                 120                 125             


Tyr Thr Pro Ser Met Ser Ser Val Glu Val Asp Lys Ala Val Glu Met 
    130                 135                 140                 


Ala Leu Gln Ala Trp Ser Ser Ala Val Pro Leu Ser Phe Val Arg Ile 
145                 150                 155                 160 


Asn Ser Gly Glu Ala Asp Ile Met Ile Ser Phe Glu Asn Gly Asp His 
                165                 170                 175     


Gly Asp Ser Tyr Pro Phe Asp Gly Pro Arg Gly Thr Leu Ala His Ala 
            180                 185                 190         


Phe Ala Pro Gly Glu Gly Leu Gly Gly Asp Thr His Phe Asp Asn Ala 
        195                 200                 205             


Glu Lys Trp Thr Met Gly Thr Asn Gly Phe Asn Leu Phe Thr Val Ala 
    210                 215                 220                 


Ala His Glu Phe Gly His Ala Leu Gly Leu Ala His Ser Thr Asp Pro 
225                 230                 235                 240 


Ser Ala Leu Met Tyr Pro Thr Tyr Lys Tyr Lys Asn Pro Tyr Gly Phe 
                245                 250                 255     


His Leu Pro Lys Asp Asp Val Lys Gly Ile Gln Ala Leu Tyr Gly Pro 
            260                 265                 270         


Arg Lys Val Phe Leu Gly Lys Pro Thr Leu Pro His Ala Pro His His 
        275                 280                 285             


Lys Pro Ser Ile Pro Asp Leu Cys Asp Ser Ser Ser Ser Phe Asp Ala 
    290                 295                 300                 


Val Thr Met Leu Gly Lys Glu Leu Leu Leu Phe Lys Asp Arg Ile Phe 
305                 310                 315                 320 


Trp Arg Arg Gln Val His Leu Arg Thr Gly Ile Arg Pro Ser Thr Ile 
                325                 330                 335     


Thr Ser Ser Phe Pro Gln Leu Met Ser Asn Val Asp Ala Ala Tyr Glu 
            340                 345                 350         


Val Ala Glu Arg Gly Thr Ala Tyr Phe Phe Lys Gly Pro His Tyr Trp 
        355                 360                 365             


Ile Thr Arg Gly Phe Gln Met Gln Gly Pro Pro Arg Thr Ile Tyr Asp 
    370                 375                 380                 


Phe Gly Phe Pro Arg His Val Gln Gln Ile Asp Ala Ala Val Tyr Leu 
385                 390                 395                 400 


Arg Glu Pro Gln Lys Thr Leu Phe Phe Val Gly Asp Glu Tyr Tyr Ser 
                405                 410                 415     


Tyr Asp Glu Arg Lys Arg Lys Met Glu Lys Asp Tyr Pro Lys Asn Thr 
            420                 425                 430         


Glu Glu Glu Phe Ser Gly Val Asn Gly Gln Ile Asp Ala Ala Val Glu 
        435                 440                 445             


Leu Asn Gly Tyr Ile Tyr Phe Phe Ser Gly Pro Lys Thr Tyr Lys Tyr 
    450                 455                 460                 


Asp Thr Glu Lys Glu Asp Val Val Ser Val Val Lys Ser Ser Ser Trp 
465                 470                 475                 480 


Ile Gly Cys 
            


<210>  10
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  10

Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 
1               5                   10                  15      


Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 
        35                  40                  45              


Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 
    50                  55                  60                  


Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 
65                  70                  75                  80  


Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 
        115                 120                 125             


Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 
        195                 200                 205             


Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 
225                 230                 235                 240 


Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 
                245                 250                 255     


Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 
            260                 265                 270         


Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 
        275                 280                 285             


Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 
    290                 295                 300                 


Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 
305                 310                 315                 320 


Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 
                325                 330                 335     


Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 
            340                 345                 350         


Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 
        355                 360                 365             


Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 
    370                 375                 380                 


Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 
385                 390                 395                 400 


Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 
                405                 410                 415     


His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 
            420                 425                 430         


Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 
        435                 440                 445             


Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 
    450                 455                 460                 


Asn Cys Arg Lys Asn 
465                 


<210>  11
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Arg Ser Arg Gly Gly Arg Ala Ala Pro Gly Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Gly Gln Ala Pro Arg Trp Ser Arg Trp Arg Val Pro 
            20                  25                  30          


Gly Arg Leu Leu Leu Leu Leu Leu Pro Ala Leu Cys Cys Leu Pro Gly 
        35                  40                  45              


Ala Ala Arg Ala Ala Ala Ala Ala Ala Gly Ala Gly Asn Arg Ala Ala 
    50                  55                  60                  


Val Ala Val Ala Val Ala Arg Ala Asp Glu Ala Glu Ala Pro Phe Ala 
65                  70                  75                  80  


Gly Gln Asn Trp Leu Lys Ser Tyr Gly Tyr Leu Leu Pro Tyr Asp Ser 
                85                  90                  95      


Arg Ala Ser Ala Leu His Ser Ala Lys Ala Leu Gln Ser Ala Val Ser 
            100                 105                 110         


Thr Met Gln Gln Phe Tyr Gly Ile Pro Val Thr Gly Val Leu Asp Gln 
        115                 120                 125             


Thr Thr Ile Glu Trp Met Lys Lys Pro Arg Cys Gly Val Pro Asp His 
    130                 135                 140                 


Pro His Leu Ser Arg Arg Arg Arg Asn Lys Arg Tyr Ala Leu Thr Gly 
145                 150                 155                 160 


Gln Lys Trp Arg Gln Lys His Ile Thr Tyr Ser Ile His Asn Tyr Thr 
                165                 170                 175     


Pro Lys Val Gly Glu Leu Asp Thr Arg Lys Ala Ile Arg Gln Ala Phe 
            180                 185                 190         


Asp Val Trp Gln Lys Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr 
        195                 200                 205             


His Glu Ile Lys Ser Asp Arg Lys Glu Ala Asp Ile Met Ile Phe Phe 
    210                 215                 220                 


Ala Ser Gly Phe His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly 
225                 230                 235                 240 


Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr 
                245                 250                 255     


His Phe Asp Ser Asp Glu Pro Trp Thr Leu Gly Asn Ala Asn His Asp 
            260                 265                 270         


Gly Asn Asp Leu Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu 
        275                 280                 285             


Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile Met Ala Pro Phe Tyr 
    290                 295                 300                 


Gln Tyr Met Glu Thr His Asn Phe Lys Leu Pro Gln Asp Asp Leu Gln 
305                 310                 315                 320 


Gly Ile Gln Lys Ile Tyr Gly Pro Pro Ala Glu Pro Leu Glu Pro Thr 
                325                 330                 335     


Arg Pro Leu Pro Thr Leu Pro Val Arg Arg Ile His Ser Pro Ser Glu 
            340                 345                 350         


Arg Lys His Glu Arg Gln Pro Arg Pro Pro Arg Pro Pro Leu Gly Asp 
        355                 360                 365             


Arg Pro Ser Thr Pro Gly Thr Lys Pro Asn Ile Cys Asp Gly Asn Phe 
    370                 375                 380                 


Asn Thr Val Ala Leu Phe Arg Gly Glu Met Phe Val Phe Lys Asp Arg 
385                 390                 395                 400 


Trp Phe Trp Arg Leu Arg Asn Asn Arg Val Gln Glu Gly Tyr Pro Met 
                405                 410                 415     


Gln Ile Glu Gln Phe Trp Lys Gly Leu Pro Ala Arg Ile Asp Ala Ala 
            420                 425                 430         


Tyr Glu Arg Ala Asp Gly Arg Phe Val Phe Phe Lys Gly Asp Lys Tyr 
        435                 440                 445             


Trp Val Phe Lys Glu Val Thr Val Glu Pro Gly Tyr Pro His Ser Leu 
    450                 455                 460                 


Gly Glu Leu Gly Ser Cys Leu Pro Arg Glu Gly Ile Asp Thr Ala Leu 
465                 470                 475                 480 


Arg Trp Glu Pro Val Gly Lys Thr Tyr Phe Phe Lys Gly Glu Arg Tyr 
                485                 490                 495     


Trp Arg Tyr Ser Glu Glu Arg Arg Ala Thr Asp Pro Gly Tyr Pro Lys 
            500                 505                 510         


Pro Ile Thr Val Trp Lys Gly Ile Pro Gln Ala Pro Gln Gly Ala Phe 
        515                 520                 525             


Ile Ser Lys Glu Gly Tyr Tyr Thr Tyr Phe Tyr Lys Gly Arg Asp Tyr 
    530                 535                 540                 


Trp Lys Phe Asp Asn Gly Ile Asn Lys Leu Ser Val Glu Pro Gly Tyr 
545                 550                 555                 560 


Pro Arg Asn Ile Leu Arg Asp Trp Met Gly Cys Asn Gln Lys Glu Val 
                565                 570                 575     


Glu Arg Arg Lys Glu Arg Arg Leu Pro Gln Asp Asp Val Asp Ile Met 
            580                 585                 590         


Val Thr Ile Asn Asp Val Pro Gly Ser Val Asn Ala Val Ala Val Val 
        595                 600                 605             


Ile Pro Cys Ile Leu Ser Leu Cys Ile Leu Val Leu Val Tyr Thr Ile 
    610                 615                 620                 


Phe Gln Phe Lys Asn Lys Thr Gly Pro Gln Pro Val Thr Tyr Tyr Lys 
625                 630                 635                 640 


Arg Pro Val Gln Glu Trp Val 
                645         


<210>  12
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Leu Arg Leu Arg Leu Leu Ala Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Pro Pro Ala Arg Ala Pro Lys Pro Ser Ala Gln Asp Val Ser Leu Gly 
            20                  25                  30          


Val Asp Trp Leu Thr Arg Tyr Gly Tyr Leu Pro Pro Pro His Pro Ala 
        35                  40                  45              


Gln Ala Gln Leu Gln Ser Pro Glu Lys Leu Arg Asp Ala Ile Lys Val 
    50                  55                  60                  


Met Gln Arg Phe Ala Gly Leu Pro Glu Thr Gly Arg Met Asp Pro Gly 
65                  70                  75                  80  


Thr Val Ala Thr Met Arg Lys Pro Arg Cys Ser Leu Pro Asp Val Leu 
                85                  90                  95      


Gly Val Ala Gly Leu Val Arg Arg Arg Arg Arg Tyr Ala Leu Ser Gly 
            100                 105                 110         


Ser Val Trp Lys Lys Arg Thr Leu Thr Trp Arg Val Arg Ser Phe Pro 
        115                 120                 125             


Gln Ser Ser Gln Leu Ser Gln Glu Thr Val Arg Val Leu Met Ser Tyr 
    130                 135                 140                 


Ala Leu Met Ala Trp Gly Met Glu Ser Gly Leu Thr Phe His Glu Val 
145                 150                 155                 160 


Asp Ser Pro Gln Gly Gln Glu Pro Asp Ile Leu Ile Asp Phe Ala Arg 
                165                 170                 175     


Ala Phe His Gln Asp Ser Tyr Pro Phe Asp Gly Leu Gly Gly Thr Leu 
            180                 185                 190         


Ala His Ala Phe Phe Pro Gly Glu His Pro Ile Ser Gly Asp Thr His 
        195                 200                 205             


Phe Asp Asp Glu Glu Thr Trp Thr Phe Gly Ser Lys Asp Gly Glu Gly 
    210                 215                 220                 


Thr Asp Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala Leu Gly 
225                 230                 235                 240 


Leu Gly His Ser Ser Ala Pro Asn Ser Ile Met Arg Pro Phe Tyr Gln 
                245                 250                 255     


Gly Pro Val Gly Asp Pro Asp Lys Tyr Arg Leu Ser Gln Asp Asp Arg 
            260                 265                 270         


Asp Gly Leu Gln Gln Leu Tyr Gly Lys Ala Pro Gln Thr Pro Tyr Asp 
        275                 280                 285             


Lys Pro Thr Arg Lys Pro Leu Ala Pro Pro Pro Gln Pro Pro Ala Ser 
    290                 295                 300                 


Pro Thr His Ser Pro Ser Phe Pro Ile Pro Asp Arg Cys Glu Gly Asn 
305                 310                 315                 320 


Phe Asp Ala Ile Ala Asn Ile Arg Gly Glu Thr Phe Phe Phe Lys Gly 
                325                 330                 335     


Pro Trp Phe Trp Arg Leu Gln Pro Ser Gly Gln Leu Val Ser Pro Arg 
            340                 345                 350         


Pro Ala Arg Leu His Arg Phe Trp Glu Gly Leu Pro Ala Gln Val Arg 
        355                 360                 365             


Val Val Gln Ala Ala Tyr Ala Arg His Arg Asp Gly Arg Ile Leu Leu 
    370                 375                 380                 


Phe Ser Gly Pro Gln Phe Trp Val Phe Gln Asp Arg Gln Leu Glu Gly 
385                 390                 395                 400 


Gly Ala Arg Pro Leu Thr Glu Leu Gly Leu Pro Pro Gly Glu Glu Val 
                405                 410                 415     


Asp Ala Val Phe Ser Trp Pro Gln Asn Gly Lys Thr Tyr Leu Val Arg 
            420                 425                 430         


Gly Arg Gln Tyr Trp Arg Tyr Asp Glu Ala Ala Ala Arg Pro Asp Pro 
        435                 440                 445             


Gly Tyr Pro Arg Asp Leu Ser Leu Trp Glu Gly Ala Pro Pro Ser Pro 
    450                 455                 460                 


Asp Asp Val Thr Val Ser Asn Ala Gly Asp Thr Tyr Phe Phe Lys Gly 
465                 470                 475                 480 


Ala His Tyr Trp Arg Phe Pro Lys Asn Ser Ile Lys Thr Glu Pro Asp 
                485                 490                 495     


Ala Pro Gln Pro Met Gly Pro Asn Trp Leu Asp Cys Pro Ala Pro Ser 
            500                 505                 510         


Ser Gly Pro Arg Ala Pro Arg Pro Pro Lys Ala Thr Pro Val Ser Glu 
        515                 520                 525             


Thr Cys Asp Cys Gln Cys Glu Leu Asn Gln Ala Ala Gly Arg Trp Pro 
    530                 535                 540                 


Ala Pro Ile Pro Leu Leu Leu Leu Pro Leu Leu Val Gly Gly Val Ala 
545                 550                 555                 560 


Ser Arg 
        


<210>  13
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys Ser Leu Pro Ile Leu Leu Leu Leu Cys Val Ala Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Asp Gly Ala Ala Arg Gly Glu Asp Thr Ser Met Asn 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Asn Tyr Tyr Asp Leu Lys Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Val Arg Arg Lys Asp Ser Gly Pro Val Val Lys Lys Ile 
    50                  55                  60                  


Arg Glu Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp 
65                  70                  75                  80  


Ser Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Gly His Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp 
        115                 120                 125             


Ala Val Asp Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Asn Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn 
            180                 185                 190         


Gly Asp Ala His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr 
225                 230                 235                 240 


His Ser Leu Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile 
                245                 250                 255     


Asn Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Asp Ser Pro Glu Thr 
            260                 265                 270         


Pro Leu Val Pro Thr Glu Pro Val Pro Pro Glu Pro Gly Thr Pro Ala 
        275                 280                 285             


Asn Cys Asp Pro Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly 
    290                 295                 300                 


Glu Ile Leu Ile Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg 
305                 310                 315                 320 


Lys Leu Glu Pro Glu Leu His Leu Ile Ser Ser Phe Trp Pro Ser Leu 
                325                 330                 335     


Pro Ser Gly Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val 
            340                 345                 350         


Phe Ile Phe Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val 
        355                 360                 365             


Arg Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr 
    370                 375                 380                 


Val Arg Lys Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr 
385                 390                 395                 400 


Tyr Phe Phe Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn 
                405                 410                 415     


Ser Met Glu Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly 
            420                 425                 430         


Ile Asp Ser Lys Ile Asp Ala Val Phe Glu Glu Phe Gly Phe Phe Tyr 
        435                 440                 445             


Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys Lys 
    450                 455                 460                 


Val Thr His Thr Leu Lys Ser Asn Ser Trp Leu Asn Cys 
465                 470                 475         


<210>  14
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Ala Ala Ser Ile Phe Arg Pro Thr Leu Leu Leu Cys Trp Leu 
1               5                   10                  15      


Ala Ala Pro Trp Pro Thr Gln Pro Glu Ser Leu Phe His Ser Arg Asp 
            20                  25                  30          


Arg Ser Asp Leu Glu Pro Ser Pro Leu Arg Gln Ala Lys Pro Ile Ala 
        35                  40                  45              


Asp Leu His Ala Ala Gln Arg Phe Leu Ser Arg Tyr Gly Trp Ser Gly 
    50                  55                  60                  


Val Trp Ala Ala Trp Gly Pro Ser Pro Glu Gly Pro Pro Glu Thr Pro 
65                  70                  75                  80  


Lys Gly Ala Ala Leu Ala Glu Ala Val Arg Arg Phe Gln Arg Ala Asn 
                85                  90                  95      


Ala Leu Pro Ala Ser Gly Glu Leu Asp Ala Ala Thr Leu Ala Ala Met 
            100                 105                 110         


Asn Arg Pro Arg Cys Gly Val Pro Asp Met Arg Pro Pro Pro Pro Ser 
        115                 120                 125             


Ala Pro Pro Ser Pro Pro Gly Pro Pro Pro Arg Ala Arg Ser Arg Arg 
    130                 135                 140                 


Ser Pro Arg Ala Pro Leu Ser Leu Ser Arg Arg Gly Trp Gln Pro Arg 
145                 150                 155                 160 


Gly Tyr Pro Asp Gly Gly Ala Ala Gln Ala Phe Ser Lys Arg Thr Leu 
                165                 170                 175     


Ser Trp Arg Leu Leu Gly Glu Ala Leu Ser Ser Gln Leu Ser Ala Ala 
            180                 185                 190         


Asp Gln Arg Arg Ile Val Ala Leu Ala Phe Arg Met Trp Ser Glu Val 
        195                 200                 205             


Thr Pro Leu Asp Phe Arg Glu Asp Leu Ala Ala Pro Gly Ala Ala Val 
    210                 215                 220                 


Asp Ile Lys Leu Gly Phe Gly Arg Gly Arg His Leu Gly Cys Pro Arg 
225                 230                 235                 240 


Ala Phe Asp Gly Ser Gly Gln Glu Phe Ala His Ala Trp Arg Leu Gly 
                245                 250                 255     


Asp Ile His Phe Asp Asp Asp Glu His Phe Thr Pro Pro Thr Ser Asp 
            260                 265                 270         


Thr Gly Ile Ser Leu Leu Lys Val Ala Val His Glu Ile Gly His Val 
        275                 280                 285             


Leu Gly Leu Pro His Thr Tyr Arg Thr Gly Ser Ile Met Gln Pro Asn 
    290                 295                 300                 


Tyr Ile Pro Gln Glu Pro Ala Phe Glu Leu Asp Trp Ser Asp Arg Lys 
305                 310                 315                 320 


Ala Ile Gln Lys Leu Tyr Gly Ser Cys Glu Gly Ser Phe Asp Thr Ala 
                325                 330                 335     


Phe Asp Trp Ile Arg Lys Glu Arg Asn Gln Tyr Gly Glu Val Met Val 
            340                 345                 350         


Arg Phe Ser Thr Tyr Phe Phe Arg Asn Ser Trp Tyr Trp Leu Tyr Glu 
        355                 360                 365             


Asn Arg Asn Asn Arg Thr Arg Tyr Gly Asp Pro Ile Gln Ile Leu Thr 
    370                 375                 380                 


Gly Trp Pro Gly Ile Pro Thr His Asn Ile Asp Ala Phe Val His Ile 
385                 390                 395                 400 


Trp Thr Trp Lys Arg Asp Glu Arg Tyr Phe Phe Gln Gly Asn Gln Tyr 
                405                 410                 415     


Trp Arg Tyr Asp Ser Asp Lys Asp Gln Ala Leu Thr Glu Asp Glu Gln 
            420                 425                 430         


Gly Lys Ser Tyr Pro Lys Leu Ile Ser Glu Gly Phe Pro Gly Ile Pro 
        435                 440                 445             


Ser Pro Leu Asp Thr Ala Phe Tyr Asp Arg Arg Gln Lys Leu Ile Tyr 
    450                 455                 460                 


Phe Phe Lys Glu Ser Leu Val Phe Ala Phe Asp Val Asn Arg Asn Arg 
465                 470                 475                 480 


Val Leu Asn Ser Tyr Pro Lys Arg Ile Thr Glu Val Phe Pro Ala Val 
                485                 490                 495     


Ile Pro Gln Asn His Pro Phe Arg Asn Ile Asp Ser Ala Tyr Tyr Ser 
            500                 505                 510         


Tyr Ala Tyr Asn Ser Ile Phe Phe Phe Lys Gly Asn Ala Tyr Trp Lys 
        515                 520                 525             


Val Val Asn Asp Lys Asp Lys Gln Gln Asn Ser Trp Leu Pro Ala Asn 
    530                 535                 540                 


Gly Leu Phe Pro Lys Lys Phe Ile Ser Glu Lys Trp Phe Asp Val Cys 
545                 550                 555                 560 


Asp Val His Ile Ser Thr Leu Asn Met 
                565                 


<210>  15
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Val Ala Arg Val Gly Leu Leu Leu Arg Ala Leu Gln Leu Leu Leu 
1               5                   10                  15      


Trp Gly His Leu Asp Ala Gln Pro Ala Glu Arg Gly Gly Gln Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Glu Ala Phe Leu Glu Lys Tyr Gly Tyr Leu Asn Glu 
        35                  40                  45              


Gln Val Pro Lys Ala Pro Thr Ser Thr Arg Phe Ser Asp Ala Ile Arg 
    50                  55                  60                  


Ala Phe Gln Trp Val Ser Gln Leu Pro Val Ser Gly Val Leu Asp Arg 
65                  70                  75                  80  


Ala Thr Leu Arg Gln Met Thr Arg Pro Arg Cys Gly Val Thr Asp Thr 
                85                  90                  95      


Asn Ser Tyr Ala Ala Trp Ala Glu Arg Ile Ser Asp Leu Phe Ala Arg 
            100                 105                 110         


His Arg Thr Lys Met Arg Arg Lys Lys Arg Phe Ala Lys Gln Gly Asn 
        115                 120                 125             


Lys Trp Tyr Lys Gln His Leu Ser Tyr Arg Leu Val Asn Trp Pro Glu 
    130                 135                 140                 


His Leu Pro Glu Pro Ala Val Arg Gly Ala Val Arg Ala Ala Phe Gln 
145                 150                 155                 160 


Leu Trp Ser Asn Val Ser Ala Leu Glu Phe Trp Glu Ala Pro Ala Thr 
                165                 170                 175     


Gly Pro Ala Asp Ile Arg Leu Thr Phe Phe Gln Gly Asp His Asn Asp 
            180                 185                 190         


Gly Leu Gly Asn Ala Phe Asp Gly Pro Gly Gly Ala Leu Ala His Ala 
        195                 200                 205             


Phe Leu Pro Arg Arg Gly Glu Ala His Phe Asp Gln Asp Glu Arg Trp 
    210                 215                 220                 


Ser Leu Ser Arg Arg Arg Gly Arg Asn Leu Phe Val Val Leu Ala His 
225                 230                 235                 240 


Glu Ile Gly His Thr Leu Gly Leu Thr His Ser Pro Ala Pro Arg Ala 
                245                 250                 255     


Leu Met Ala Pro Tyr Tyr Lys Arg Leu Gly Arg Asp Ala Leu Leu Ser 
            260                 265                 270         


Trp Asp Asp Val Leu Ala Val Gln Ser Leu Tyr Gly Lys Pro Leu Gly 
        275                 280                 285             


Gly Ser Val Ala Val Gln Leu Pro Gly Lys Leu Phe Thr Asp Phe Glu 
    290                 295                 300                 


Thr Trp Asp Ser Tyr Ser Pro Gln Gly Arg Arg Pro Glu Thr Gln Gly 
305                 310                 315                 320 


Pro Lys Tyr Cys His Ser Ser Phe Asp Ala Ile Thr Val Asp Arg Gln 
                325                 330                 335     


Gln Gln Leu Tyr Ile Phe Lys Gly Ser His Phe Trp Glu Val Ala Ala 
            340                 345                 350         


Asp Gly Asn Val Ser Glu Pro Arg Pro Leu Gln Glu Arg Trp Val Gly 
        355                 360                 365             


Leu Pro Pro Asn Ile Glu Ala Ala Ala Val Ser Leu Asn Asp Gly Asp 
    370                 375                 380                 


Phe Tyr Phe Phe Lys Gly Gly Arg Cys Trp Arg Phe Arg Gly Pro Lys 
385                 390                 395                 400 


Pro Val Trp Gly Leu Pro Gln Leu Cys Arg Ala Gly Gly Leu Pro Arg 
                405                 410                 415     


His Pro Asp Ala Ala Leu Phe Phe Pro Pro Leu Arg Arg Leu Ile Leu 
            420                 425                 430         


Phe Lys Gly Ala Arg Tyr Tyr Val Leu Ala Arg Gly Gly Leu Gln Val 
        435                 440                 445             


Glu Pro Tyr Tyr Pro Arg Ser Leu Gln Asp Trp Gly Gly Ile Pro Glu 
    450                 455                 460                 


Glu Val Ser Gly Ala Leu Pro Arg Pro Asp Gly Ser Ile Ile Phe Phe 
465                 470                 475                 480 


Arg Asp Asp Arg Tyr Trp Arg Leu Asp Gln Ala Lys Leu Gln Ala Thr 
                485                 490                 495     


Thr Ser Gly Arg Trp Ala Thr Glu Leu Pro Trp Met Gly Cys Trp His 
            500                 505                 510         


Ala Asn Ser Gly Ser Ala Leu Phe 
        515                 520 


<210>  16
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln 
1               5                   10                  15      


Ile Ser Lys Ala Phe Pro Val Ser Ser Lys Glu Lys Asn Thr Lys Thr 
            20                  25                  30          


Val Gln Asp Tyr Leu Glu Lys Phe Tyr Gln Leu Pro Ser Asn Gln Tyr 
        35                  40                  45              


Gln Ser Thr Arg Lys Asn Gly Thr Asn Val Ile Val Glu Lys Leu Lys 
    50                  55                  60                  


Glu Met Gln Arg Phe Phe Gly Leu Asn Val Thr Gly Lys Pro Asn Glu 
65                  70                  75                  80  


Glu Thr Leu Asp Met Met Lys Lys Pro Arg Cys Gly Val Pro Asp Ser 
                85                  90                  95      


Gly Gly Phe Met Leu Thr Pro Gly Asn Pro Lys Trp Glu Arg Thr Asn 
            100                 105                 110         


Leu Thr Tyr Arg Ile Arg Asn Tyr Thr Pro Gln Leu Ser Glu Ala Glu 
        115                 120                 125             


Val Glu Arg Ala Ile Lys Asp Ala Phe Glu Leu Trp Ser Val Ala Ser 
    130                 135                 140                 


Pro Leu Ile Phe Thr Arg Ile Ser Gln Gly Glu Ala Asp Ile Asn Ile 
145                 150                 155                 160 


Ala Phe Tyr Gln Arg Asp His Gly Asp Asn Ser Pro Phe Asp Gly Pro 
                165                 170                 175     


Asn Gly Ile Leu Ala His Ala Phe Gln Pro Gly Gln Gly Ile Gly Gly 
            180                 185                 190         


Asp Ala His Phe Asp Ala Glu Glu Thr Trp Thr Asn Thr Ser Ala Asn 
        195                 200                 205             


Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Ala His Ser Ser Asp Pro Gly Ala Leu Met Tyr Pro Asn Tyr Ala 
225                 230                 235                 240 


Phe Arg Glu Thr Ser Asn Tyr Ser Leu Pro Gln Asp Asp Ile Asp Gly 
                245                 250                 255     


Ile Gln Ala Ile Tyr Gly Leu Ser Ser Asn Pro Thr Ile Glu Gln Pro 
            260                 265                 270         


Thr Gly Pro Ser Thr Pro Lys Pro Cys Asp Pro Ser Leu Thr Phe Asp 
        275                 280                 285             


Ala Ile Thr Thr Leu Arg Gly Glu Thr Ile Glu Leu Phe Phe Lys Asp 
    290                 295                 300                 


Arg Tyr Phe Trp Arg Arg His Pro Gln Leu Gln Arg Val Glu Met Asn 
305                 310                 315                 320 


Phe Ile Ser Leu Phe Trp Pro Ser Leu Pro Thr Gly Ile Gln Ala Ala 
                325                 330                 335     


Tyr Glu Asp Phe Asp Arg Asp Leu Ile Phe Leu Phe Lys Gly Asn Gln 
            340                 345                 350         


Tyr Trp Ala Leu Ser Gly Tyr Asp Ile Leu Gln Gly Tyr Pro Lys Asp 
        355                 360                 365             


Ile Ser Asn Tyr Gly Phe Pro Ser Ser Val Gln Ala Thr Ile Glu Asp 
    370                 375                 380                 


Ala Ala Val Phe Tyr Arg Ser Lys Thr Tyr Phe Phe Val Asn Asp Gln 
385                 390                 395                 400 


Phe Trp Arg Tyr Asp Asn Gln Arg Gln Phe Met Glu Pro Gly Tyr Pro 
                405                 410                 415     


Lys Ser Ile Ser Gly Ala Phe Pro Gly Thr Ile Glu Glu Ser Lys Val 
            420                 425                 430         


Asp Ala Val Phe Gln Gln Glu His Phe Phe His Val Phe Ser Gly Pro 
        435                 440                 445             


Arg Tyr Tyr Ala Phe Asp Leu Ile Ala Gln Arg Val Thr Arg Val Ala 
    450                 455                 460                 


Arg Gly Asn Lys Trp Leu Asn Cys Arg Tyr Gly 
465                 470                 475 


<210>  17
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Lys Phe Leu Leu Ile Leu Leu Leu Gln Ala Thr Ala Ser Gly Ala 
1               5                   10                  15      


Leu Pro Leu Asn Ser Ser Thr Ser Leu Glu Lys Asn Asn Val Leu Phe 
            20                  25                  30          


Gly Glu Arg Tyr Leu Glu Lys Phe Tyr Gly Leu Glu Ile Asn Lys Leu 
        35                  40                  45              


Pro Val Thr Lys Met Lys Tyr Ser Gly Asn Leu Met Lys Glu Lys Ile 
    50                  55                  60                  


Gln Glu Met Gln His Phe Leu Gly Leu Lys Val Thr Gly Gln Leu Asp 
65                  70                  75                  80  


Thr Ser Thr Leu Glu Met Met His Ala Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val His His Phe Arg Glu Met Pro Gly Gly Pro Val Trp Arg Lys His 
            100                 105                 110         


Tyr Ile Thr Tyr Arg Ile Asn Asn Tyr Thr Pro Asp Met Asn Arg Glu 
        115                 120                 125             


Asp Val Asp Tyr Ala Ile Arg Lys Ala Phe Gln Val Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Lys Phe Ser Lys Ile Asn Thr Gly Met Ala Asp Ile Leu 
145                 150                 155                 160 


Val Val Phe Ala Arg Gly Ala His Gly Asp Phe His Ala Phe Asp Gly 
                165                 170                 175     


Lys Gly Gly Ile Leu Ala His Ala Phe Gly Pro Gly Ser Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Phe Trp Thr Thr His Ser Gly 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Thr Ala Val His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Gly His Ser Ser Asp Pro Lys Ala Val Met Phe Pro Thr Tyr 
225                 230                 235                 240 


Lys Tyr Val Asp Ile Asn Thr Phe Arg Leu Ser Ala Asp Asp Ile Arg 
                245                 250                 255     


Gly Ile Gln Ser Leu Tyr Gly Asp Pro Lys Glu Asn Gln Arg Leu Pro 
            260                 265                 270         


Asn Pro Asp Asn Ser Glu Pro Ala Leu Cys Asp Pro Asn Leu Ser Phe 
        275                 280                 285             


Asp Ala Val Thr Thr Val Gly Asn Lys Ile Phe Phe Phe Lys Asp Arg 
    290                 295                 300                 


Phe Phe Trp Leu Lys Val Ser Glu Arg Pro Lys Thr Ser Val Asn Leu 
305                 310                 315                 320 


Ile Ser Ser Leu Trp Pro Thr Leu Pro Ser Gly Ile Glu Ala Ala Tyr 
                325                 330                 335     


Glu Ile Glu Ala Arg Asn Gln Val Phe Leu Phe Lys Asp Asp Lys Tyr 
            340                 345                 350         


Trp Leu Ile Ser Asn Leu Arg Pro Glu Pro Asn Tyr Pro Lys Ser Ile 
        355                 360                 365             


His Ser Phe Gly Phe Pro Asn Phe Val Lys Lys Ile Asp Ala Ala Val 
    370                 375                 380                 


Phe Asn Pro Arg Phe Tyr Arg Thr Tyr Phe Phe Val Asp Asn Gln Tyr 
385                 390                 395                 400 


Trp Arg Tyr Asp Glu Arg Arg Gln Met Met Asp Pro Gly Tyr Pro Lys 
                405                 410                 415     


Leu Ile Thr Lys Asn Phe Gln Gly Ile Gly Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Phe Tyr Ser Lys Asn Lys Tyr Tyr Tyr Phe Phe Gln Gly Ser Asn Gln 
        435                 440                 445             


Phe Glu Tyr Asp Phe Leu Leu Gln Arg Ile Thr Lys Thr Leu Lys Ser 
    450                 455                 460                 


Asn Ser Trp Phe Gly Cys 
465                 470 


<210>  18
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Arg Leu Leu Leu Leu Phe Leu Phe Phe Ile Thr Phe Ser Ser 
1               5                   10                  15      


Ala Phe Pro Leu Val Arg Met Thr Glu Asn Glu Glu Asn Met Gln Leu 
            20                  25                  30          


Ala Gln Ala Tyr Leu Asn Gln Phe Tyr Ser Leu Glu Ile Glu Gly Asn 
        35                  40                  45              


His Leu Val Gln Ser Lys Asn Arg Ser Leu Ile Asp Asp Lys Ile Arg 
    50                  55                  60                  


Glu Met Gln Ala Phe Phe Gly Leu Thr Val Thr Gly Lys Leu Asp Ser 
65                  70                  75                  80  


Asn Thr Leu Glu Ile Met Lys Thr Pro Arg Cys Gly Val Pro Asp Val 
                85                  90                  95      


Gly Gln Tyr Gly Tyr Thr Leu Pro Gly Trp Arg Lys Tyr Asn Leu Thr 
            100                 105                 110         


Tyr Arg Ile Ile Asn Tyr Thr Pro Asp Met Ala Arg Ala Ala Val Asp 
        115                 120                 125             


Glu Ala Ile Gln Glu Gly Leu Glu Val Trp Ser Lys Val Thr Pro Leu 
    130                 135                 140                 


Lys Phe Thr Lys Ile Ser Lys Gly Ile Ala Asp Ile Met Ile Ala Phe 
145                 150                 155                 160 


Arg Thr Arg Val His Gly Arg Cys Pro Arg Tyr Phe Asp Gly Pro Leu 
                165                 170                 175     


Gly Val Leu Gly His Ala Phe Pro Pro Gly Pro Gly Leu Gly Gly Asp 
            180                 185                 190         


Thr His Phe Asp Glu Asp Glu Asn Trp Thr Lys Asp Gly Ala Gly Phe 
        195                 200                 205             


Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu 
    210                 215                 220                 


Ser His Ser Asn Asp Gln Thr Ala Leu Met Phe Pro Asn Tyr Val Ser 
225                 230                 235                 240 


Leu Asp Pro Arg Lys Tyr Pro Leu Ser Gln Asp Asp Ile Asn Gly Ile 
                245                 250                 255     


Gln Ser Ile Tyr Gly Gly Leu Pro Lys Glu Pro Ala Lys Pro Lys Glu 
            260                 265                 270         


Pro Thr Ile Pro His Ala Cys Asp Pro Asp Leu Thr Phe Asp Ala Ile 
        275                 280                 285             


Thr Thr Phe Arg Arg Glu Val Met Phe Phe Lys Gly Arg His Leu Trp 
    290                 295                 300                 


Arg Ile Tyr Tyr Asp Ile Thr Asp Val Glu Phe Glu Leu Ile Ala Ser 
305                 310                 315                 320 


Phe Trp Pro Ser Leu Pro Ala Asp Leu Gln Ala Ala Tyr Glu Asn Pro 
                325                 330                 335     


Arg Asp Lys Ile Leu Val Phe Lys Asp Glu Asn Phe Trp Met Ile Arg 
            340                 345                 350         


Gly Tyr Ala Val Leu Pro Asp Tyr Pro Lys Ser Ile His Thr Leu Gly 
        355                 360                 365             


Phe Pro Gly Arg Val Lys Lys Ile Asp Ala Ala Val Cys Asp Lys Thr 
    370                 375                 380                 


Thr Arg Lys Thr Tyr Phe Phe Val Gly Ile Trp Cys Trp Arg Phe Asp 
385                 390                 395                 400 


Glu Met Thr Gln Thr Met Asp Lys Gly Phe Pro Gln Arg Val Val Lys 
                405                 410                 415     


His Phe Pro Gly Ile Ser Ile Arg Val Asp Ala Ala Phe Gln Tyr Lys 
            420                 425                 430         


Gly Phe Phe Phe Phe Ser Arg Gly Ser Lys Gln Phe Glu Tyr Asp Ile 
        435                 440                 445             


Lys Thr Lys Asn Ile Thr Arg Ile Met Arg Thr Asn Thr Trp Phe Gln 
    450                 455                 460                 


Cys Lys Glu Pro Lys Asn Ser Ser Phe Gly Phe Asp Ile Asn Lys Glu 
465                 470                 475                 480 


Lys Ala His Ser Gly Gly Ile Lys Ile Leu Tyr His Lys Ser Leu Ser 
                485                 490                 495     


Leu Phe Ile Phe Gly Ile Val His Leu Leu Lys Asn Thr Ser Ile Tyr 
            500                 505                 510         


Gln 
    


<210>  19
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Pro Ala Ala Trp Leu Arg Ser Ala Ala Ala Arg Ala Leu Leu 
1               5                   10                  15      


Pro Pro Met Leu Leu Leu Leu Leu Gln Pro Pro Pro Leu Leu Ala Arg 
            20                  25                  30          


Ala Leu Pro Pro Asp Val His His Leu His Ala Glu Arg Arg Gly Pro 
        35                  40                  45              


Gln Pro Trp His Ala Ala Leu Pro Ser Ser Pro Ala Pro Ala Pro Ala 
    50                  55                  60                  


Thr Gln Glu Ala Pro Arg Pro Ala Ser Ser Leu Arg Pro Pro Arg Cys 
65                  70                  75                  80  


Gly Val Pro Asp Pro Ser Asp Gly Leu Ser Ala Arg Asn Arg Gln Lys 
                85                  90                  95      


Arg Phe Val Leu Ser Gly Gly Arg Trp Glu Lys Thr Asp Leu Thr Tyr 
            100                 105                 110         


Arg Ile Leu Arg Phe Pro Trp Gln Leu Val Gln Glu Gln Val Arg Gln 
        115                 120                 125             


Thr Met Ala Glu Ala Leu Lys Val Trp Ser Asp Val Thr Pro Leu Thr 
    130                 135                 140                 


Phe Thr Glu Val His Glu Gly Arg Ala Asp Ile Met Ile Asp Phe Ala 
145                 150                 155                 160 


Arg Tyr Trp His Gly Asp Asp Leu Pro Phe Asp Gly Pro Gly Gly Ile 
                165                 170                 175     


Leu Ala His Ala Phe Phe Pro Lys Thr His Arg Glu Gly Asp Val His 
            180                 185                 190         


Phe Asp Tyr Asp Glu Thr Trp Thr Ile Gly Asp Asp Gln Gly Thr Asp 
        195                 200                 205             


Leu Leu Gln Val Ala Ala His Glu Phe Gly His Val Leu Gly Leu Gln 
    210                 215                 220                 


His Thr Thr Ala Ala Lys Ala Leu Met Ser Ala Phe Tyr Thr Phe Arg 
225                 230                 235                 240 


Tyr Pro Leu Ser Leu Ser Pro Asp Asp Cys Arg Gly Val Gln His Leu 
                245                 250                 255     


Tyr Gly Gln Pro Trp Pro Thr Val Thr Ser Arg Thr Pro Ala Leu Gly 
            260                 265                 270         


Pro Gln Ala Gly Ile Asp Thr Asn Glu Ile Ala Pro Leu Glu Pro Asp 
        275                 280                 285             


Ala Pro Pro Asp Ala Cys Glu Ala Ser Phe Asp Ala Val Ser Thr Ile 
    290                 295                 300                 


Arg Gly Glu Leu Phe Phe Phe Lys Ala Gly Phe Val Trp Arg Leu Arg 
305                 310                 315                 320 


Gly Gly Gln Leu Gln Pro Gly Tyr Pro Ala Leu Ala Ser Arg His Trp 
                325                 330                 335     


Gln Gly Leu Pro Ser Pro Val Asp Ala Ala Phe Glu Asp Ala Gln Gly 
            340                 345                 350         


His Ile Trp Phe Phe Gln Gly Ala Gln Tyr Trp Val Tyr Asp Gly Glu 
        355                 360                 365             


Lys Pro Val Leu Gly Pro Ala Pro Leu Thr Glu Leu Gly Leu Val Arg 
    370                 375                 380                 


Phe Pro Val His Ala Ala Leu Val Trp Gly Pro Glu Lys Asn Lys Ile 
385                 390                 395                 400 


Tyr Phe Phe Arg Gly Arg Asp Tyr Trp Arg Phe His Pro Ser Thr Arg 
                405                 410                 415     


Arg Val Asp Ser Pro Val Pro Arg Arg Ala Thr Asp Trp Arg Gly Val 
            420                 425                 430         


Pro Ser Glu Ile Asp Ala Ala Phe Gln Asp Ala Asp Gly Tyr Ala Tyr 
        435                 440                 445             


Phe Leu Arg Gly Arg Leu Tyr Trp Lys Phe Asp Pro Val Lys Val Lys 
    450                 455                 460                 


Ala Leu Glu Gly Phe Pro Arg Leu Val Gly Pro Asp Phe Phe Gly Cys 
465                 470                 475                 480 


Ala Glu Pro Ala Asn Thr Phe Leu 
                485             


<210>  20
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Met His Leu Ala Phe Leu Val Leu Leu Cys Leu Pro Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Ser Gly Ala Ala Lys Glu Glu Asp Ser Asn Lys Asp 
            20                  25                  30          


Leu Ala Gln Gln Tyr Leu Glu Lys Tyr Tyr Asn Leu Glu Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Arg Arg Lys Asp Ser Asn Leu Ile Val Lys Lys Ile Gln 
    50                  55                  60                  


Gly Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp Thr 
65                  70                  75                  80  


Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp Val 
                85                  90                  95      


Gly His Phe Ser Ser Phe Pro Gly Met Pro Lys Trp Arg Lys Thr His 
            100                 105                 110         


Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Arg Asp Ala 
        115                 120                 125             


Val Asp Ser Ala Ile Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr 
    130                 135                 140                 


Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile 
145                 150                 155                 160 


Ser Phe Ala Val Lys Glu His Gly Asp Phe Tyr Ser Phe Asp Gly Pro 
                165                 170                 175     


Gly His Ser Leu Ala His Ala Tyr Pro Pro Gly Pro Gly Leu Tyr Gly 
            180                 185                 190         


Asp Ile His Phe Asp Asp Asp Glu Lys Trp Thr Glu Asp Ala Ser Gly 
        195                 200                 205             


Thr Asn Leu Phe Leu Val Ala Ala His Glu Leu Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr Asn 
225                 230                 235                 240 


Ser Phe Thr Glu Leu Ala Gln Phe Arg Leu Ser Gln Asp Asp Val Asn 
                245                 250                 255     


Gly Thr Ile Glu Gln Ser Leu Tyr Gly Pro Pro Pro Ala Ser Thr Glu 
            260                 265                 270         


Glu Pro Leu Val Pro Thr Lys Ser Val Pro Ser Gly Ser Glu Met Pro 
        275                 280                 285             


Ala Lys Cys Asp Pro Ala Leu Ser Phe Asp Ala Ile Ser Thr Leu Arg 
    290                 295                 300                 


Gly Glu Tyr Leu Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg Ser His 
305                 310                 315                 320 


Trp Asn Pro Glu Pro Glu Phe His Leu Ile Ser Ala Phe Trp Pro Ser 
                325                 330                 335     


Leu Pro Ser Tyr Leu Asp Ala Ala Tyr Glu Val Asn Ser Arg Asp Thr 
            340                 345                 350         


Val Phe Ile Phe Lys Gly Asn Glu Phe Trp Ala Ile Arg Gly Asn Glu 
        355                 360                 365             


Val Gln Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro 
    370                 375                 380                 


Thr Ile Arg Lys Ile Asp Ala Ala Val Ser Asp Lys Glu Lys Lys Lys 
385                 390                 395                 400 


Thr Tyr Phe Phe Ala Ala Asp Lys Tyr Trp Arg Phe Asp Glu Asn Ser 
                405                 410                 415     


Gln Ser Met Glu Gln Gly Phe Pro Arg Leu Ile Ala Asp Asp Phe Pro 
            420                 425                 430         


Gly Val Glu Pro Lys Val Asp Ala Val Leu Gln Ala Phe Gly Phe Phe 
        435                 440                 445             


Tyr Phe Phe Ser Gly Ser Ser Gln Phe Glu Phe Asp Pro Asn Ala Arg 
    450                 455                 460                 


Met Val Thr His Ile Leu Lys Ser Asn Ser Trp Leu His Cys 
465                 470                 475             


<210>  21
<211>  20
<212>  DNA
<213>  Avian

<400>  21
ttaacgagga tccattggag                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Avian

<400>  22
agcctgcttt gaacactcta                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Avian

<400>  23
agaggagtac tcctgaaagt                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Avian

<400>  24
actgctgaac ataagctcct                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  25
ccgcatcaag gtggtcttta                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  26
catacactca ccattagggc                                                   20


<210>  27
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  27
tgtggagggc agtgctgc                                                     18


<210>  28
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  28
taaagaccac cttgatgcgg                                                   20


<210>  29
<211>  21
<212>  DNA
<213>  Avian

<400>  29
tactgctgat atcatgatct c                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Avian

<400>  30
tctagaatca tctgaccaag t                                                 21


<210>  31
<211>  20
<212>  DNA
<213>  Avian

<400>  31
aatgacagca tcaggtacgg                                                   20


<210>  32
<211>  19
<212>  DNA
<213>  Avian

<400>  32
atggtcagga ctgaggcac                                                    19


<210>  33
<211>  22
<212>  DNA
<213>  Avian

<400>  33
agatgtatca gatgcaagat ct                                                22


<210>  34
<211>  21
<212>  DNA
<213>  Avian

<400>  34
gaagtctgct tctacaggta t                                                 21


<210>  35
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  35

Leu Arg Gly Glu Thr Met Ile Phe Lys Asp 
1               5                   10  


<210>  36
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  36

Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala Ala Val His 
1               5                   10                  15      


Phe Glu Asp 
            


<210>  37
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  37

Lys Lys Ile Ser Ala Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu 
1               5                   10                  15      


Leu Phe Ser Gly Asn Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile 
            20                  25                  30          


Met Asp Lys Asp Tyr Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile 
        35                  40                  45              


Gly Asp 
    50  


<210>  38
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  38

Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn Gln Val Trp 
1               5                   10                  15      


Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr Pro Arg Leu 
            20                  25                  30          


Ile Glu Glu Asp Phe Pro Gly 
        35                  


<210>  39
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  39

Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr Pro Arg Leu 
1               5                   10                  15      


Ile Glu Glu Asp Phe Pro Gly 
            20              


<210>  40
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  40

Lys Val Asp Ala Val Tyr Glu Lys Asn Gly Tyr Ile Tyr Phe Phe Asn 
1               5                   10                  15      


Gly Pro Ile Gln Phe Glu Tyr Ser Ile Trp Ser Asn Arg Ile Val Arg 
            20                  25                  30          


Val Met Pro Ala Asn Ser Ile Leu Trp Cys 
        35                  40          


<210>  41
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Tyr Ile Tyr Phe Phe Asn Gly Pro Ile Gln Phe Glu Tyr Ser Ile 
1               5                   10                  15      


Trp Ser Asn Arg Ile 
            20      


<210>  42
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  42

Leu Pro Asn Arg Ile Asp Ala Ala Tyr Glu His Pro Ser His Asp Leu 
1               5                   10                  15      


Ile Phe Ile Phe Arg Gly Arg Lys Phe Trp Ala Leu Asn Gly Tyr Asp 
            20                  25                  30          


Ile Gly Tyr Pro Lys Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val 
        35                  40                  45              


<210>  43
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  43

Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg Lys Phe 
1               5                   10                  15      


Trp Ala Leu Asn Gly Tyr Asp Ile 
            20                  


<210>  44
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  44

Thr Pro Asp Lys Cys Asp Pro Ser Leu Ser Leu Asp Ala Ile Thr Ser 
1               5                   10                  15      


Leu Arg Gly Glu Thr Met Ile Phe Lys Asp Arg Phe Phe Trp Arg Leu 
            20                  25                  30          


His Pro Gln Gln Val Asp Ala Glu Leu Phe Leu Thr Lys Ser Phe Trp 
        35                  40                  45              


Pro Glu 
    50  


<210>  45
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  45

Ser Leu Arg Gly Glu Thr Met Ile Phe Lys Asp Arg Phe Phe Trp Arg 
1               5                   10                  15      


Leu His Pro Gln Gln Val Asp Ala Glu Leu Phe Leu Thr Lys Ser Phe 
            20                  25                  30          


Trp Pro Glu 
        35  


<210>  46
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  46

Pro Ile Gln Phe Glu Tyr Ser Ile Trp Ser Asn Arg Ile Val Arg Met 
1               5                   10                  15      


Pro Ala 
        


<210>  47
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  47

Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn Gln Val Trp 
1               5                   10                  15      


Arg Tyr Asp Asp Thr 
            20      


<210>  48
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  48

Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe Lys Glu 
1               5                   10                  15      


Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly Tyr Pro 
            20                  25                  30          


Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala 
        35                  40                  


<210>  49
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  49

Ile Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys 
1               5                   10                  15      


Gly Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr 
            20                  25                  30          


Pro Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr 
        35                  40                  45  


<210>  50
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  50

Ile Asp Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe 
1               5                   10                  15      


Arg Gly Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp 
            20                  25                  30          


Ser Glu Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu 
        35                  40                  45          


<210>  51
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  51

Pro Arg Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr 
1               5                   10                  15      


Lys Gly Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu 
            20                  25                  30          


Pro Gly Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys 
        35                  40                  45      


<210>  52
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  52

Phe Asn Thr Leu Ala Ile Leu Arg Arg Glu Met Phe Val Phe Lys Asp 
1               5                   10                  15      


Gln Trp Phe Trp Arg Val Arg Asn Asn Arg Val Met Asp Gly Tyr Pro 
            20                  25                  30          


Met Gln Ile Thr Tyr Phe Trp Arg Gly Leu Pro Pro 
        35                  40                  


<210>  53
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  53

Ile Asp Ala Val Tyr Glu Asn Ser Asp Gly Asn Phe Val Phe Phe Lys 
1               5                   10                  15      


Gly Asn Lys Tyr Trp Val Phe Lys Asp Thr Thr Leu Gln Pro Gly Tyr 
            20                  25                  30          


Pro His Asp Leu Ile Thr Leu Gly Ser Gly Ile Pro Pro 
        35                  40                  45  


<210>  54
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  54

Ile Asp Ser Ala Ile Trp Trp Glu Asp Val Gly Lys Thr Tyr Phe Phe 
1               5                   10                  15      


Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu Glu Met Lys Thr Met Asp 
            20                  25                  30          


Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp Lys Gly Ile Pro Glu 
        35                  40                  45          


<210>  55
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  55

Pro Gln Gly Ala Phe Val His Lys Glu Asn Gly Phe Thr Tyr Phe Tyr 
1               5                   10                  15      


Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn Gln Ile Leu Lys Val Glu 
            20                  25                  30          


Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp Phe Met Gly Cys 
        35                  40                  45      


<210>  56
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  56

Phe Asp Gly Ile Ala Gln Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp 
1               5                   10                  15      


Arg Phe Ile Trp Arg Thr Val Thr Pro Arg Asp Lys Pro Met Gly Pro 
            20                  25                  30          


Leu Leu Val Ala Thr Phe Trp Pro Glu Leu Pro 
        35                  40              


<210>  57
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  57

Ile Asp Ala Val Tyr Glu Ala Pro Gln Glu Glu Lys Ala Val Phe Phe 
1               5                   10                  15      


Ala Gly Asn Glu Tyr Trp Ile Tyr Ser Ala Ser Thr Leu Glu Arg Gly 
            20                  25                  30          


Tyr Pro Lys Pro Leu Thr Ser Leu Gly Leu Pro Pro 
        35                  40                  


<210>  58
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  58

Val Asp Ala Ala Phe Asn Trp Ser Lys Asn Lys Lys Thr Tyr Ile Phe 
1               5                   10                  15      


Ala Gly Asp Lys Phe Trp Arg Tyr Asn Glu Val Lys Lys Lys Met Asp 
            20                  25                  30          


Pro Gly Phe Pro Lys Leu Ile Ala Asp Ala Trp Asn Ala Ile Pro Asp 
        35                  40                  45              


<210>  59
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  59

Leu Asp Ala Val Val Asp Leu Gln Gly Gly Gly His Ser Tyr Phe Phe 
1               5                   10                  15      


Lys Gly Ala Tyr Tyr Leu Lys Leu Glu Asn Gln Ser Leu Lys Ser Val 
            20                  25                  30          


Lys Phe Gly Ser Ile Lys Ser Asp Trp Leu Gly Cys 
        35                  40                  


<210>  60
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  60

Phe Asp Ala Ile Ala Glu Ile Gly Asn Gln Leu Tyr Leu Phe Lys Asp 
1               5                   10                  15      


Gly Lys Tyr Trp Arg Phe Ser Glu Gly Arg Gly Ser Arg Pro Gln Gly 
            20                  25                  30          


Pro Phe Leu Ile Ala Asp Lys Trp Pro Ala Leu Pro Arg 
        35                  40                  45  


<210>  61
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  61

Leu Asp Ser Val Phe Glu Glu Arg Leu Ser Lys Lys Leu Phe Phe Phe 
1               5                   10                  15      


Ser Gly Arg Gln Val Trp Val Tyr Thr Gly Ala Ser Val Leu Gly Pro 
            20                  25                  30          


Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 
        35                  40          


<210>  62
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  62

Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met Leu Leu Phe Ser 
1               5                   10                  15      


Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln Met Val Asp Pro 
            20                  25                  30          


Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly Val Pro Leu 
        35                  40                  45          


<210>  63
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  63

Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr Phe Cys Gln Asp 
1               5                   10                  15      


Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu Asn Gln Val Asp 
            20                  25                  30          


Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 
        35                  40                  


<210>  64
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  64

Leu Asp Ala Met Met Leu Gly Pro Arg Gly Lys Thr Tyr Ala Phe Lys 
1               5                   10                  15      


Gly Asp Tyr Val Trp Thr Val Ser Asp Ser Gly Pro Gly Pro Leu Phe 
            20                  25                  30          


Arg Val Ser Ala Leu Trp Glu Gly Leu Pro Gly 
        35                  40              


<210>  65
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  65

Leu Asp Ala Ala Val Tyr Ser Pro Arg Thr Gln Trp Ile His Phe Phe 
1               5                   10                  15      


Lys Gly Asp Lys Val Trp Arg Tyr Ile Asn Phe Lys Met Ser Pro Gly 
            20                  25                  30          


Phe Pro Lys Lys Leu Asn Arg Val Glu Pro 
        35                  40          


<210>  66
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  66

Leu Asp Ala Ala Leu Tyr Trp Pro Leu Asn Gln Lys Val Phe Leu Phe 
1               5                   10                  15      


Lys Gly Ser Gly Tyr Trp Gln Trp Asp Glu Leu Ala Arg Thr Asp Phe 
            20                  25                  30          


Ser Ser Tyr Pro Lys Pro Ile Lys Gly Leu Phe Thr Gly Val Pro Asn 
        35                  40                  45              


<210>  67
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  67

Pro Ser Ala Ala Met Ser Trp Gln Asp Gly Arg Val Tyr Phe Phe Lys 
1               5                   10                  15      


Gly Lys Val Tyr Trp Arg Leu Asn Gln Gln Leu Arg Val Glu Lys Gly 
            20                  25                  30          


Tyr Pro Arg Asn Ile Ser His Asn Trp Met His Cys 
        35                  40                  


<210>  68
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  68

Phe Asp Ala Val Ala Gln Ile Arg Gly Glu Ala Phe Phe Phe Lys Gly 
1               5                   10                  15      


Lys Tyr Phe Trp Arg Leu Thr Arg Asp Arg His Leu Val Ser Leu Gln 
            20                  25                  30          


Pro Ala Gln Met His Arg Phe Trp Arg Gly Leu Pro Leu 
        35                  40                  45  


<210>  69
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  69

Val Asp Ala Val Tyr Glu Arg Thr Ser Asp His Lys Ile Val Phe Phe 
1               5                   10                  15      


Lys Gly Asp Arg Tyr Trp Val Phe Lys Asp Asn Asn Val Glu Glu Gly 
            20                  25                  30          


Tyr Pro Arg Pro Val Ser Asp Phe Ser Leu Pro Pro 
        35                  40                  


<210>  70
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  70

Val Asp Ala Val Tyr Glu Arg Thr Ser Asp His Lys Ile Val Phe Phe 
1               5                   10                  15      


Lys Gly Asp Arg Tyr Trp Val Phe Lys Asp Asn Asn Val Glu Glu Gly 
            20                  25                  30          


Tyr Pro Arg Pro Val Ser Asp Phe Ser Leu Pro Pro 
        35                  40                  


<210>  71
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  71

Ile Asp Ala Ala Phe Ser Trp Ala His Asn Asp Arg Thr Tyr Phe Phe 
1               5                   10                  15      


Lys Asp Gln Leu Tyr Trp Arg Tyr Asp Asp His Thr Arg His Met Asp 
            20                  25                  30          


Pro Gly Tyr Pro Ala Gln Ser Pro Leu Trp Arg Gly Val Pro Ser 
        35                  40                  45          


<210>  72
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  72

Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe Lys Gly 
1               5                   10                  15      


Arg Trp Phe Trp Arg Val Arg His Asn Arg Val Leu Asp Asn Tyr Pro 
            20                  25                  30          


Met Pro Ile Gly His Phe Trp Arg Gly Leu Pro Gly 
        35                  40                  


<210>  73
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  73

Ile Ser Ala Ala Tyr Glu Arg Gln Asp Gly Arg Phe Val Phe Phe Lys 
1               5                   10                  15      


Gly Asp Arg Tyr Trp Leu Phe Arg Glu Ala Asn Leu Glu Pro Gly Tyr 
            20                  25                  30          


Pro Gln Pro Leu Thr Ser Tyr Gly Leu Gly Ile Pro Tyr 
        35                  40                  45  


<210>  74
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  74

Ile Asp Thr Ala Ile Trp Trp Glu Pro Thr Gly His Thr Phe Phe Phe 
1               5                   10                  15      


Gln Glu Asp Arg Tyr Trp Arg Phe Asn Glu Glu Thr Gln Arg Gly Asp 
            20                  25                  30          


Pro Gly Tyr Pro Lys Pro Ile Ser Val Trp Gln Gly Ile Pro Ala 
        35                  40                  45          


<210>  75
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  75

Pro Lys Gly Ala Phe Leu Ser Asn Asp Ala Ala Tyr Thr Tyr Phe Tyr 
1               5                   10                  15      


Lys Gly Thr Lys Tyr Trp Lys Phe Asp Asn Glu Arg Leu Arg Met Glu 
            20                  25                  30          


Pro Gly Tyr Pro Lys Ser Ile Leu Arg Asp Phe Met Gly Cys 
        35                  40                  45      


<210>  76
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  76

Phe Asp Ala Val Thr Met Leu Gly Lys Glu Leu Leu Leu Phe Lys Asp 
1               5                   10                  15      


Arg Ile Phe Trp Arg Arg Gln Val His Leu Arg Thr Gly Ile Arg Pro 
            20                  25                  30          


Ser Thr Ile Thr Ser Ser Phe Pro Gln Leu Met Ser 
        35                  40                  


<210>  77
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  77

Val Asp Ala Ala Tyr Glu Val Ala Glu Arg Gly Thr Ala Tyr Phe Phe 
1               5                   10                  15      


Lys Gly Pro His Tyr Trp Ile Thr Arg Gly Phe Gln Met Gln Gly Pro 
            20                  25                  30          


Pro Arg Thr Ile Tyr Asp Phe Gly Phe Pro Arg 
        35                  40              


<210>  78
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  78

Ile Asp Ala Ala Val Tyr Leu Arg Glu Pro Gln Lys Thr Leu Phe Phe 
1               5                   10                  15      


Val Gly Asp Glu Tyr Tyr Ser Tyr Asp Glu Arg Lys Arg Lys Met Glu 
            20                  25                  30          


Lys Asp Tyr Pro Lys Asn Thr Glu Glu Glu Phe Ser Gly Val Asn Gly 
        35                  40                  45              


<210>  79
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  79

Ile Asp Ala Ala Val Glu Leu Asn Gly Tyr Ile Tyr Phe Phe Ser Gly 
1               5                   10                  15      


Pro Lys Thr Tyr Lys Tyr Asp Thr Glu Lys Glu Asp Val Val Ser Val 
            20                  25                  30          


Val Lys Ser Ser Ser Trp Ile Gly Cys 
        35                  40      


<210>  80
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  80

Phe Asp Ala Ile Thr Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp 
1               5                   10                  15      


Arg Phe Tyr Met Arg Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn 
            20                  25                  30          


Phe Ile Ser Val Phe Trp Pro Gln Leu Pro Asn 
        35                  40              


<210>  81
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  81

Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu Val Arg Phe Phe 
1               5                   10                  15      


Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn Val Leu His Gly 
            20                  25                  30          


Tyr Pro Lys 
        35  


<210>  82
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  82

Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly Lys Thr Tyr Phe Phe 
1               5                   10                  15      


Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr Lys Arg Ser Met Asp 
            20                  25                  30          


Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe Pro Gly Ile Gly His 
        35                  40                  45              


<210>  83
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  83

Val Asp Ala Val Phe Met Lys Asp Gly Phe Phe Tyr Phe Phe His Gly 
1               5                   10                  15      


Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr Lys Arg Ile Leu Thr Leu 
            20                  25                  30          


Gln Lys Ala Asn Ser Trp Phe Asn Cys 
        35                  40      


<210>  84
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  84

Arg Gln Pro Arg Pro Pro Arg Pro Pro Leu Gly Asp Arg Pro Ser Thr 
1               5                   10                  15      


Pro Gly Thr Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Val Phe 
            20                  25                  30          


Arg Gly Glu Met Phe Val Phe Lys Asp Arg 
        35                  40          


<210>  85
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  85

Phe Trp Arg Leu Arg Asn Asn Arg Val Gln Glu Gly Tyr Pro Met Gln 
1               5                   10                  15      


Ile Glu Gln Phe Trp Lys Gly Leu Pro Ala Arg Ile Asp Ala Ala Tyr 
            20                  25                  30          


Glu Arg Ala Asp Gly Arg Phe Val Phe Phe Lys Gly Asp 
        35                  40                  45  


<210>  86
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  86

Trp Val Phe Lys Glu Val Thr Val Glu Pro Gly Tyr Pro His Ser Leu 
1               5                   10                  15      


Gly Glu Leu Gly Ser Cys Leu Pro Arg Glu Gly Ile Asp Thr Ala Leu 
            20                  25                  30          


Arg Trp Glu Pro Val Gly Lys Thr Tyr Phe Phe Lys Gly Glu Arg 
        35                  40                  45          


<210>  87
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  87

Trp Arg Tyr Ser Glu Glu Arg Arg Ala Thr Asp Pro Gly Tyr Pro Lys 
1               5                   10                  15      


Pro Ile Thr Val Trp Lys Gly Ile Pro Gln Ala Pro Gln Gly Ala Phe 
            20                  25                  30          


Ile Ser Lys Glu Gly Tyr Tyr Thr Tyr Phe Tyr Lys Gly Arg 
        35                  40                  45      


<210>  88
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  88

Phe Asp Ala Ile Ala Asn Ile Arg Gly Glu Thr Phe Phe Phe Lys Gly 
1               5                   10                  15      


Pro Trp Phe Trp Arg Leu Gln Pro Ser Gly Gln Leu Val Ser Pro Arg 
            20                  25                  30          


Pro Ala Arg Leu His Arg Phe Trp Glu Gly Leu Pro 
        35                  40                  


<210>  89
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  89

Val Gln Ala Ala Tyr Ala Arg His Arg Asp Gly Arg Ile Leu Leu Phe 
1               5                   10                  15      


Ser Gly Pro Gln Phe Trp Val Phe Gln Asp Arg Gln Leu Glu Gly Gly 
            20                  25                  30          


Ala Arg Pro Leu Thr Glu Leu Gly Leu Pro Pro 
        35                  40              


<210>  90
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  90

Val Asp Ala Val Phe Ser Trp Pro Gln Asn Gly Lys Thr Tyr Leu Val 
1               5                   10                  15      


Arg Gly Arg Gln Tyr Trp Arg Tyr Asp Glu Ala Ala Ala Arg Pro Asp 
            20                  25                  30          


Pro Gly Tyr Pro Arg Asp Leu Ser Leu Trp Glu Gly Ala Pro Pro 
        35                  40                  45          


<210>  91
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  91

Pro Asp Asp Val Thr Val Ser Asn Ala Gly Asp Thr Tyr Phe Phe Lys 
1               5                   10                  15      


Gly Ala His Tyr Trp Arg Phe Pro Lys Asn Ser Ile Lys Thr Glu Pro 
            20                  25                  30          


Asp Ala Pro Gln Pro Met Gly Pro Asn Trp Leu Asp Cys 
        35                  40                  45  


<210>  92
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  92

Phe Asp Ala Val Ser Thr Leu Arg Gly Glu Ile Leu Ile Phe Lys Asp 
1               5                   10                  15      


Arg His Phe Trp Arg Lys Ser Leu Arg Lys Leu Glu Pro Glu Leu His 
            20                  25                  30          


Leu Ile Ser Ser Phe Trp Pro Ser Leu Pro 
        35                  40          


<210>  93
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  93

Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val Phe Ile Phe 
1               5                   10                  15      


Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val Arg Ala Gly 
            20                  25                  30          


Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro 
        35                  40              


<210>  94
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  94

Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr Tyr Phe Phe 
1               5                   10                  15      


Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn Ser Met Glu 
            20                  25                  30          


Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly Ile Asp Ser 
        35                  40                  45              


<210>  95
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  95

Pro Ser Gly Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val 
1               5                   10                  15      


Phe Ile Phe Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val 
            20                  25                  30          


Arg Ala Gly Tyr Pro Arg Gly Ile His 
        35                  40      


<210>  96
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  96

Phe Asp Thr Ala Phe Asp Trp Ile Arg Lys Glu Arg Asn Gln Tyr Gly 
1               5                   10                  15      


Glu Val Met Val Arg Phe Ser Thr Tyr Phe Phe Arg Asn Ser Trp Tyr 
            20                  25                  30          


Trp Leu Tyr Glu Asn Arg Asn Asn Arg Thr Arg Tyr Gly Asp Pro Ile 
        35                  40                  45              


Gln Ile Leu Thr Gly Trp Pro Gly Ile Pro Thr 
    50                  55                  


<210>  97
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  97

Ile Asp Ala Phe Val His Ile Trp Thr Trp Lys Arg Asp Glu Arg Tyr 
1               5                   10                  15      


Phe Phe Gln Gly Asn Gln Tyr Trp Arg Tyr Asp Ser Asp Lys Asp Gln 
            20                  25                  30          


Ala Leu Thr Glu Asp Glu Gln Gly Lys Ser Tyr Pro Lys Leu Ile Ser 
        35                  40                  45              


Glu Gly Phe Pro Gly Ile Pro Ser 
    50                  55      


<210>  98
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  98

Leu Asp Thr Ala Phe Tyr Asp Arg Arg Gln Lys Leu Ile Tyr Phe Phe 
1               5                   10                  15      


Lys Glu Ser Leu Val Phe Ala Phe Asp Val Asn Arg Asn Arg Val Leu 
            20                  25                  30          


Asn Ser Tyr Pro Lys Arg Ile Thr Glu Val Thr Pro Ala Val Ile Pro 
        35                  40                  45              


Gln 
    


<210>  99
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  99

Ile Asp Ser Ala Tyr Tyr Ser Tyr Ala Tyr Asn Ser Ile Phe Phe Phe 
1               5                   10                  15      


Lys Gly Asn Ala Tyr Trp Lys Val Val Asn Asp Lys Asp Lys Gln Gln 
            20                  25                  30          


Asn Ser Trp Leu Pro Ala Asn Gly Leu Phe Pro Lys 
        35                  40                  


<210>  100
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  100

Phe Asp Ala Ile Thr Val Asp Arg Gln Gln Gln Leu Tyr Ile Phe Lys 
1               5                   10                  15      


Gly Ser His Phe Trp Glu Val Ala Ala Asp Gly Asn Val Ser Glu Pro 
            20                  25                  30          


Arg Pro Leu Gln Glu Arg Trp Val Gly Leu Pro Pro 
        35                  40                  


<210>  101
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  101

Ile Glu Ala Ala Ala Val Ser Leu Asn Asp Gly Asp Phe Tyr Phe Phe 
1               5                   10                  15      


Lys Gly Gly Arg Cys Trp Arg Phe Arg Gly Pro Lys Pro Val Trp Gly 
            20                  25                  30          


Leu Pro Gln Leu Cys Arg Ala Gly Gly Leu Pro Arg 
        35                  40                  


<210>  102
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  102

Pro Asp Ala Ala Leu Phe Phe Pro Pro Leu Arg Arg Leu Ile Leu Phe 
1               5                   10                  15      


Lys Gly Ala Arg Tyr Tyr Val Leu Arg Gly Leu Gln Val Glu Pro Tyr 
            20                  25                  30          


Tyr Pro Arg Ser Leu Gln Asp Trp Gly Gly Ile Pro Glu 
        35                  40                  45  


<210>  103
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  103

Val Ser Gly Ala Leu Pro Arg Pro Asp Gly Ser Ile Ile Phe Phe Arg 
1               5                   10                  15      


Asp Asp Arg Tyr Trp Arg Leu Asp Gln Ala Lys Leu Gln Ala Thr Thr 
            20                  25                  30          


Ser Gly Arg Trp Ala Thr Glu Leu Pro Trp Met Gly Cys 
        35                  40                  45  


<210>  104
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  104

Phe Asp Ala Ile Thr Thr Leu Arg Gly Glu Ile Leu Phe Phe Lys Asp 
1               5                   10                  15      


Arg Tyr Trp Arg Arg His Pro Gln Leu Gln Arg Val Glu Met Asn Phe 
            20                  25                  30          


Ile Ser Leu Phe Trp Pro Ser Leu Pro Thr 
        35                  40          


<210>  105
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  105

Ile Gln Ala Ala Tyr Glu Asp Phe Asp Arg Asp Leu Ile Phe Leu Phe 
1               5                   10                  15      


Lys Gly Asn Gln Tyr Trp Ala Leu Ser Gly Tyr Asp Ile Leu Gln Gly 
            20                  25                  30          


Tyr Pro Lys Asp Ile Ser Asn Tyr Gly Phe Pro Ser 
        35                  40                  


<210>  106
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  106

Ile Asp Ala Ala Val Phe Tyr Arg Ser Lys Thr Tyr Phe Phe Val Asn 
1               5                   10                  15      


Asp Gln Phe Trp Arg Tyr Asp Asn Gln Arg Gln Phe Met Glu Pro Gly 
            20                  25                  30          


Tyr Pro Lys Ser Ile Ser Gly Ala Phe Pro Gly Ile Glu Ser 
        35                  40                  45      


<210>  107
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  107

Val Asp Ala Val Phe Gln Gln Glu His Phe Phe His Val Phe Ser Gly 
1               5                   10                  15      


Pro Arg Tyr Tyr Ala Phe Asp Leu Ile Ala Gln Arg Val Thr Arg Val 
            20                  25                  30          


Arg Asn Lys Trp Leu Asn Cys 
        35                  


<210>  108
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  108

Phe Asp Ala Val Thr Thr Val Gly Asn Lys Ile Phe Phe Phe Lys Asp 
1               5                   10                  15      


Arg Phe Phe Trp Leu Lys Val Ser Pro Lys Thr Ser Val Asn Leu Ile 
            20                  25                  30          


Ser Ser Leu Trp Pro Thr Leu Pro Ser 
        35                  40      


<210>  109
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  109

Ile Glu Ala Ala Tyr Glu Ile Glu Ala Arg Asn Gln Val Phe Leu Phe 
1               5                   10                  15      


Lys Asp Asp Lys Tyr Trp Leu Ile Ser Asn Leu Arg Pro Glu Pro Asn 
            20                  25                  30          


Tyr Pro Lys Ser Ile His Ser Phe Gly Phe Pro Asn 
        35                  40                  


<210>  110
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  110

Ile Asp Ala Ala Val Phe Asn Pro Arg Phe Tyr Arg Thr Tyr Phe Phe 
1               5                   10                  15      


Val Asp Asn Gln Tyr Trp Arg Tyr Asp Glu Arg Arg Gln Met Met Asp 
            20                  25                  30          


Pro Gly Tyr Pro Lys Leu Ile Thr Lys Asn Phe Gln Gly Ile Gly 
        35                  40                  45          


<210>  111
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  111

Ile Asp Ala Val Phe Tyr Ser Lys Asn Lys Tyr Tyr Tyr Phe Phe Gln 
1               5                   10                  15      


Gly Ser Asn Gln Phe Glu Tyr Asp Phe Leu Leu Gln Arg Ile Thr Lys 
            20                  25                  30          


Thr Leu Lys Ser Asn Ser Trp Phe Gly Cys 
        35                  40          


<210>  112
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  112

Phe Asp Ala Ile Thr Thr Phe Arg Arg Glu Val Met Phe Phe Lys Gly 
1               5                   10                  15      


Arg His Leu Trp Arg Ile Tyr Tyr Asp Ile Thr Asp Val Glu Phe Glu 
            20                  25                  30          


Leu Ile Ala Ser Phe Trp Pro Ser Leu Pro Ala 
        35                  40              


<210>  113
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  113

Leu Gln Ala Ala Tyr Glu Asn Pro Arg Asp Lys Ile Leu Val Phe Lys 
1               5                   10                  15      


Asp Glu Asn Phe Trp Met Ile Arg Gly Tyr Ala Val Leu Pro Asp Tyr 
            20                  25                  30          


Pro Lys Ser Ile His Thr Leu Gly Phe Pro Gly 
        35                  40              


<210>  114
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  114

Ile Asp Ala Ala Val Cys Asp Lys Thr Thr Arg Lys Thr Tyr Phe Phe 
1               5                   10                  15      


Val Gly Ile Trp Cys Trp Arg Phe Asp Glu Met Thr Gln Thr Met Asp 
            20                  25                  30          


Lys Gly Phe Pro Gln Arg Val Val Lys His Phe Pro Gly Ile Ser Ile 
        35                  40                  45              


<210>  115
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  115

Val Asp Ala Ala Phe Gln Tyr Lys Gly Phe Phe Phe Phe Ser Arg Gly 
1               5                   10                  15      


Ser Lys Gln Phe Glu Tyr Asp Ile Lys Thr Lys Asn Ile Thr Arg Ile 
            20                  25                  30          


Met Arg Thr Asn Thr Trp Phe Gln Cys 
        35                  40      


<210>  116
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  116

Phe Asp Ala Val Ser Thr Ile Arg Gly Glu Leu Phe Phe Phe Lys Ala 
1               5                   10                  15      


Gly Phe Val Trp Arg Leu Arg Gly Gly Gln Leu Gln Pro Gly Tyr Pro 
            20                  25                  30          


Ala Ser Arg His Trp Gln Gly Leu Pro Ser 
        35                  40          


<210>  117
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  117

Val Asp Ala Ala Phe Glu Asp Ala Gln Gly His Ile Trp Phe Phe Gln 
1               5                   10                  15      


Gly Ala Gln Tyr Trp Val Tyr Asp Gly Glu Lys Pro Val Leu Gly Pro 
            20                  25                  30          


Ala Pro Leu Thr Glu Leu Gly Leu Val Arg 
        35                  40          


<210>  118
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  118

Val His Ala Ala Leu Val Trp Gly Pro Glu Lys Asn Lys Ile Tyr Phe 
1               5                   10                  15      


Phe Arg Gly Arg Asp Tyr Trp Arg Phe His Pro Ser Thr Arg Arg Val 
            20                  25                  30          


Asp Ser Pro Val Pro Arg Arg Ala Thr Asp Trp Arg Gly Val Pro Ser 
        35                  40                  45              


<210>  119
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  119

Ile Asp Ala Ala Phe Gln Asp Ala Asp Gly Tyr Ala Tyr Phe Leu Arg 
1               5                   10                  15      


Gly Arg Leu Tyr Trp Lys Phe Asp Pro Val Lys Val Lys Ala Leu Glu 
            20                  25                  30          


Gly Phe Pro Arg Leu Val Gly Pro Asp Phe Phe Gly Cys 
        35                  40                  45  


<210>  120
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  120

Phe Asp Ala Ile Ser Thr Leu Arg Gly Glu Tyr Leu Phe Phe Lys Asp 
1               5                   10                  15      


Arg Tyr Phe Trp Arg Arg Ser His Trp Asn Pro Glu Pro Glu Phe His 
            20                  25                  30          


Leu Ile Ser Ala Phe Trp Pro Ser Leu Pro Ser 
        35                  40              


<210>  121
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  121

Leu Asp Ala Ala Tyr Glu Val Asn Ser Arg Asp Thr Val Phe Ile Phe 
1               5                   10                  15      


Lys Gly Asn Glu Phe Trp Ala Ile Arg Gly Asn Glu Val Gln Ala Gly 
            20                  25                  30          


Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro 
        35                  40                  


<210>  122
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  122

Ile Asp Ala Ala Val Ser Asp Lys Glu Lys Lys Lys Thr Tyr Phe Phe 
1               5                   10                  15      


Ala Ala Asp Lys Tyr Trp Arg Phe Asp Glu Asn Ser Gln Ser Met Glu 
            20                  25                  30          


Gln Gly Phe Pro Arg Leu Ile Ala Asp Asp Phe Pro Gly Val Glu Pro 
        35                  40                  45              


<210>  123
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  123

Val Asp Ala Val Leu Gln Ala Phe Gly Phe Phe Tyr Phe Phe Ser Gly 
1               5                   10                  15      


Ser Ser Gln Phe Glu Phe Asp Pro Asn Ala Arg Met Val Thr His Ile 
            20                  25                  30          


Leu Lys Ser Asn Ser Trp Leu His Cys 
        35                  40      


<210>  124
<211>  448
<212>  PRT
<213>  Dog

<400>  124

Ala Phe Leu Phe Leu Ser Trp Thr Gln Cys Trp Ser Leu Pro Leu Pro 
1               5                   10                  15      


Ser Asp Gly Asp Asp Asp Leu Ser Glu Glu Asp Phe Gln Leu Ala Glu 
            20                  25                  30          


Arg Tyr Leu Lys Ser Tyr Tyr Tyr Pro Leu Asn Pro Ala Gly Ile Leu 
        35                  40                  45              


Lys Lys Ser Ala Ala Gly Ser Val Ala Asp Arg Leu Arg Glu Met Gln 
    50                  55                  60                  


Ser Phe Phe Gly Leu Glu Val Thr Gly Lys Leu Asp Asp Asn Thr Leu 
65                  70                  75                  80  


Asp Ile Met Lys Lys Pro Arg Cys Gly Val Pro Asp Val Gly Glu Tyr 
                85                  90                  95      


Asn Val Phe Pro Arg Thr Leu Lys Trp Ser Lys Thr Asn Leu Tyr Ile 
            100                 105                 110         


Val Asn Tyr Thr Pro Asp Leu Thr His Ser Glu Val Glu Lys Ala Phe 
        115                 120                 125             


Lys Lys Ala Phe Lys Val Trp Ser Asp Val Thr Pro Leu Asn Phe Thr 
    130                 135                 140                 


Arg Leu His Asp Gly Thr Ala Asp Ile Met Ile Ser Phe Gly Thr Lys 
145                 150                 155                 160 


Glu His Gly Asp Phe Tyr Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala 
                165                 170                 175     


His Ala Phe Pro Pro Gly Pro Asn Tyr Gly Gly Asp Ala His Phe Asp 
            180                 185                 190         


Asp Asp Glu Thr Trp Thr Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu 
        195                 200                 205             


Val Ala Ala His Glu Phe Gly His Ser Leu Gly Leu Asp His Ser Lys 
    210                 215                 220                 


Asp Pro Gly Ala Leu Met Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser 
225                 230                 235                 240 


His Phe Met Leu Pro Asp Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr 
                245                 250                 255     


Gly Pro Gly Asp Glu Asp Pro Asn Pro Arg His Pro Lys Thr Pro Asp 
            260                 265                 270         


Lys Cys Asp Pro Ser Leu Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly 
        275                 280                 285             


Glu Thr Met Ile Phe Lys Asp Arg Phe Phe Trp Arg Leu His Pro Gln 
    290                 295                 300                 


Gln Val Asp Ala Glu Leu Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu 
305                 310                 315                 320 


Pro Asn Arg Ile Asp Ala Ala Tyr Glu His Pro Ser Arg Asp Leu Ile 
                325                 330                 335     


Phe Ile Phe Arg Gly Arg Lys Tyr Trp Ala Leu Asn Gly Tyr Asp Ile 
            340                 345                 350         


Gly Tyr Pro Gln Lys Ile Ser Glu Leu Gly Phe Pro Lys Glu Val Lys 
        355                 360                 365             


Lys Ile Ser Ala Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Phe 
    370                 375                 380                 


Phe Ser Gly Asn Gln Val Trp Ser Tyr Asp Asp Thr Asn Gln Ile Met 
385                 390                 395                 400 


Asp Lys Asp Tyr Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly 
                405                 410                 415     


Asp Lys Val Asp Ala Val Tyr Glu Lys Asn Gly Tyr Ile Tyr Phe Phe 
            420                 425                 430         


Asn Gly Pro Ile Gln Phe Glu Tyr Asn Ile Trp Ser Asn Pro Tyr Cys 
        435                 440                 445             


<210>  125
<211>  1348
<212>  PRT
<213>  Dog

<400>  125

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Ser Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Ala Thr Ala Arg Lys 
            20                  25                  30          


Gly Pro Thr Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Asp Asp Gly Ile Pro Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ser Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Arg Pro Pro Gly Pro Pro Gly Lys Ala Gly Glu Asp Gly His 
    130                 135                 140                 


Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly Pro Gln 
145                 150                 155                 160 


Gly Arg Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe Lys Gly Ile Arg 
                165                 170                 175     


Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro Gly Ala Pro Gly 
            180                 185                 190         


Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly Thr Pro Gly Gln 
        195                 200                 205             


Thr Gly Arg Leu Pro Gly Glu Arg Gly Arg Val Gly Ala Pro Gly Pro 
    210                 215                 220                 


Ala Gly Arg Ser Asp Gly Ser Val Gly Pro Val Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Ile Gly Ser Ala Gly Pro Pro Gly Phe Pro Gly Ala Pro Gly Pro Lys 
                245                 250                 255     


Gly Glu Ile Gly Pro Val Gly Asn Pro Gly Pro Ala Gly Pro Ala Gly 
            260                 265                 270         


Pro Arg Gly Glu Val Gly Leu Pro Gly Val Ser Gly Pro Val Gly Pro 
        275                 280                 285             


Pro Gly Asn Pro Gly Ala Asn Gly Leu Thr Gly Ala Lys Gly Ala Ala 
    290                 295                 300                 


Gly Leu Pro Gly Val Ala Gly Ala Pro Gly Leu Pro Gly Pro Arg Gly 
305                 310                 315                 320 


Ile Pro Gly Pro Val Gly Ala Ala Gly Ala Thr Gly Arg Ile Val Gly 
                325                 330                 335     


Glu Pro Gly Pro Ala Gly Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu 
            340                 345                 350         


Pro Gly Ser Ala Gly Ala Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu 
        355                 360                 365             


Gly Lys Arg Gly Pro Asn Gly Glu Ala Gly Ser Ala Gly Pro Ser Gly 
    370                 375                 380                 


Pro Pro Gly Leu Arg Gly Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala 
385                 390                 395                 400 


Asp Gly Pro Ala Gly Val Met Gly Pro Pro Gly Pro Arg Gly Ala Thr 
                405                 410                 415     


Gly Pro Ala Gly Val Arg Gly Pro Asn Gly Asp Ser Gly Arg Pro Gly 
            420                 425                 430         


Glu Pro Gly Leu Met Gly Pro Arg Gly Phe Pro Gly Ala Pro Gly Asn 
        435                 440                 445             


Val Gly Pro Ala Gly Lys Glu Gly Pro Met Gly Leu Pro Gly Ile Asp 
    450                 455                 460                 


Gly Arg Pro Gly Pro Ile Gly Pro Ala Gly Arg Glu Pro Gly Asn Ile 
465                 470                 475                 480 


Gly Phe Pro Gly Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly 
                485                 490                 495     


Asp Lys Gly His Ala Gly Leu Ala Gly Arg Ala Pro Gly Pro Asp Gly 
            500                 505                 510         


Asn Asn Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly 
        515                 520                 525             


Lys Gly Glu Gln Gly Pro Ala Gly Pro Pro Gly Phe Gln Gly Leu Pro 
    530                 535                 540                 


Gly Pro Ala Gly Thr Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly 
545                 550                 555                 560 


Leu Pro Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu 
                565                 570                 575     


Arg Gly Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Ser Gly Pro Ile 
            580                 585                 590         


Gly Ser Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly 
        595                 600                 605             


Glu Pro Gly Val Leu Gly Ala Pro Gly Thr Ala Gly Ala Ser Gly Pro 
    610                 615                 620                 


Gly Gly Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys 
625                 630                 635                 640 


Gly Glu Lys Gly Glu Thr Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly 
                645                 650                 655     


Arg Asp Gly Arg Ala Pro Gly Ala Met Gly Ala Pro Gly Pro Ala Gly 
            660                 665                 670         


Ala Thr Gly Asp Arg Gly Glu Ala Gly Pro Ala Gly Pro Ala Gly Pro 
        675                 680                 685             


Ala Gly Pro Arg Gly Thr Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
    690                 695                 700                 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
705                 710                 715                 720 


Ala Lys Gly Glu Arg Gly Thr Lys Gly Pro Lys Gly Glu Asn Gly Pro 
                725                 730                 735     


Val Gly Pro Thr Gly Pro Ile Gly Ser Ala Gly Pro Ser Gly Pro Asn 
            740                 745                 750         


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
        755                 760                 765             


Ala Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
    770                 775                 780                 


Ser Gly Ile Thr Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly Lys Glu 
785                 790                 795                 800 


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
                805                 810                 815     


Glu Thr Gly Ala Ser Gly Pro Pro Gly Phe Thr Gly Glu Lys Gly Pro 
            820                 825                 830         


Ser Gly Glu Pro Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
        835                 840                 845             


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
    850                 855                 860                 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ser Val Gly Glu Pro Gly Pro 
865                 870                 875                 880 


Leu Gly Ile Ala Gly Pro Pro Gly Arg Pro Pro Gly Ala Val Gly Ala 
                885                 890                 895     


Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly Asn Pro 
            900                 905                 910         


Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Ala Gly His Lys Gly 
        915                 920                 925             


Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Val Gly Ala 
    930                 935                 940                 


Pro Gly Pro His Gly Pro Val Gly Pro Thr Gly Lys His Gly Asn Arg 
945                 950                 955                 960 


Gly Glu Pro Gly Pro Ala Gly Ser Val Gly Pro Val Gly Ala Val Gly 
                965                 970                 975     


Pro Arg Gly Pro Ser Gly Pro Gln Gly Ile Arg Gly Asp Lys Gly Glu 
            980                 985                 990         


Pro Gly Glu Lys Gly Pro Arg Gly  Leu Pro Gly Leu Lys  Gly His Asn 
        995                 1000                 1005             


Gly Leu  Gln Gly Leu Pro Gly  Leu Ala Gly Gln His  Gly Asp Gln 
    1010                 1015                 1020             


Gly Ala  Pro Gly Ser Val Gly  Pro Ala Gly Pro Arg  Gly Pro Ala 
    1025                 1030                 1035             


Gly Pro  Ser Gly Pro Ala Gly  Lys Asp Gly Arg Thr  Gly Gln Pro 
    1040                 1045                 1050             


Gly Thr  Val Gly Pro Ala Gly  Ile Arg Gly Ser Gln  Gly Ser Gln 
    1055                 1060                 1065             


Gly Pro  Ala Gly Pro Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ser Gly Gly Gly Tyr  Asp Phe Gly Tyr Glu  Gly Asp Phe 
    1085                 1090                 1095             


Tyr Arg  Ala Asp Gln Pro Arg  Ser Pro Pro Ser Leu  Arg Pro Lys 
    1100                 1105                 1110             


Asp Tyr  Glu Val Asp Ala Thr  Leu Lys Ser Leu Asn  Asn Gln Ile 
    1115                 1120                 1125             


Glu Thr  Leu Leu Thr Pro Glu  Gly Ser Arg Lys Asn  Pro Ala Arg 
    1130                 1135                 1140             


Thr Cys  Arg Asp Leu Arg Leu  Ser His Pro Glu Trp  Ser Ser Gly 
    1145                 1150                 1155             


Tyr Tyr  Trp Ile Asp Pro Asn  Gln Gly Cys Thr Met  Asp Ala Ile 
    1160                 1165                 1170             


Lys Val  Tyr Cys Asp Phe Ser  Thr Gly Glu Thr Cys  Ile Arg Ala 
    1175                 1180                 1185             


Gln Pro  Glu Asn Ile Pro Ala  Lys Asn Trp Tyr Arg  Asn Ser Lys 
    1190                 1195                 1200             


Val Lys  Lys His Ile Trp Leu  Gly Glu Thr Ile Asn  Gly Gly Thr 
    1205                 1210                 1215             


Gln Phe  Glu Tyr Asn Val Glu  Gly Val Thr Thr Lys  Glu Met Ala 
    1220                 1225                 1230             


Thr Gln  Leu Ala Phe Met Arg  Leu Leu Ala Asn His  Ala Ser Gln 
    1235                 1240                 1245             


Asn Ile  Thr Tyr His Cys Lys  Asn Ser Ile Ala Tyr  Met Asp Glu 
    1250                 1255                 1260             


Glu Thr  Gly Asn Leu Lys Lys  Ala Val Ile Leu Gln  Gly Ser Asn 
    1265                 1270                 1275             


Asp Val  Glu Leu Val Ala Glu  Gly Asn Ser Arg Phe  Thr Tyr Thr 
    1280                 1285                 1290             


Val Leu  Val Asp Gly Cys Ser  Lys Lys Thr Asn Glu  Trp Arg Lys 
    1295                 1300                 1305             


Thr Ile  Ile Glu Tyr Lys Thr  Asn Lys Pro Ser Arg  Leu Pro Ile 
    1310                 1315                 1320             


Leu Asp  Ile Ala Pro Leu Asp  Ile Gly Asp Ala Asp  Gln Glu Phe 
    1325                 1330                 1335             


Arg Val  Asp Val Gly Pro Val  Cys Phe Lys 
    1340                 1345             


<210>  126
<211>  2321
<212>  PRT
<213>  Dog

<400>  126

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Ser Ser Glu Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Glu Pro Ser Pro Met Arg Val Leu Leu Gly Ser Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Ile Thr Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Gln Val Arg Ile 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Ile Gln Asn Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Ile Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Leu 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 
        275                 280                 285             


Ala Trp Gln Gly Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Leu His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Ile Gln Thr Val Thr Trp Pro Asp Val Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Arg Asn Val Ile Leu Thr Val Lys 
385                 390                 395                 400 


Pro Ile Phe Asp Leu Ser Pro Thr Ala Pro Glu Pro Glu Glu Pro Phe 
                405                 410                 415     


Thr Phe Val Pro Glu Pro Glu Lys Pro Phe Thr Phe Ala Thr Asp Val 
            420                 425                 430         


Gly Val Thr Ala Phe Pro Glu Ala Glu Asn Arg Thr Gly Glu Ala Thr 
        435                 440                 445             


Arg Pro Trp Gly Val Pro Glu Glu Ser Thr Pro Gly Pro Ala Phe Thr 
    450                 455                 460                 


Ala Phe Thr Ser Glu Asp His Val Val Gln Val Thr Ala Val Pro Gly 
465                 470                 475                 480 


Ala Ala Glu Val Pro Gly Gln Pro Arg Leu Pro Gly Gly Val Val Phe 
                485                 490                 495     


His Tyr Arg Pro Gly Ser Ala Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
            500                 505                 510         


Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Asp Glu Gln Leu Gln 
        515                 520                 525             


Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu Gln 
    530                 535                 540                 


Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro Cys Val 
545                 550                 555                 560 


Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val Arg Pro 
                565                 570                 575     


Pro Ser Glu Thr Tyr Asp Val Tyr Cys Tyr Val Asp Lys Leu Glu Gly 
            580                 585                 590         


Glu Val Phe Phe Ile Thr Arg Leu Glu Gln Phe Thr Phe Gln Glu Ala 
        595                 600                 605             


Phe Cys Glu Ser His Asn Ala Thr Leu Ala Ser Thr Gly Gln Leu Tyr 
    610                 615                 620                 


Ala Ala Trp Arg Gln Gly Leu Asp Lys Cys Tyr Ala Gly Trp Leu Ser 
625                 630                 635                 640 


Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg Pro Ser Cys Gly 
                645                 650                 655     


Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr Pro Asn Gln Thr 
            660                 665                 670         


Gly Leu Pro Asp Pro Leu Ser Arg His His Val Phe Cys Phe Arg Gly 
        675                 680                 685             


Val Ser Gly Val Pro Ser Pro Gly Glu Glu Glu Gly Gly Thr Pro Thr 
    690                 695                 700                 


Pro Ser Val Val Glu Asp Trp Ile Pro Thr Gln Val Gly Pro Val Val 
705                 710                 715                 720 


Pro Ser Val Pro Met Gly Glu Glu Thr Thr Ala Ile Leu Asp Phe Thr 
                725                 730                 735     


Ile Glu Pro Glu Asn Gln Thr Glu Trp Glu Pro Ala Tyr Ser Pro Ala 
            740                 745                 750         


Gly Thr Ser Pro Leu Pro Gly Ile Pro Pro Thr Trp Pro Pro Thr Ser 
        755                 760                 765             


Thr Ala Thr Glu Glu Ser Thr Glu Gly Pro Ser Gly Thr Glu Val Pro 
    770                 775                 780                 


Ser Val Ser Glu Glu Pro Ser Pro Ser Glu Glu Pro Phe Pro Trp Glu 
785                 790                 795                 800 


Glu Leu Ser Thr Leu Ser Pro Pro Gly Pro Ser Gly Thr Glu Leu Pro 
                805                 810                 815     


Gly Ser Gly Glu Ala Ser Gly Val Pro Glu Val Ser Gly Asp Phe Thr 
            820                 825                 830         


Gly Ser Gly Glu Val Ser Gly His Pro Asp Ser Ser Gly Gln Leu Ser 
        835                 840                 845             


Gly Glu Ser Ala Ser Gly Leu Pro Ser Glu Asp Leu Asp Ser Ser Gly 
    850                 855                 860                 


Leu Thr Ser Ala Val Gly Ser Gly Leu Ala Ser Gly Asp Glu Asp Arg 
865                 870                 875                 880 


Ile Thr Leu Ser Ser Ile Pro Lys Val Glu Gly Glu Gly Leu Glu Thr 
                885                 890                 895     


Ser Ala Ser Gly Val Glu Asp Leu Ser Gly Leu Pro Ser Gly Arg Glu 
            900                 905                 910         


Gly Leu Glu Thr Ser Thr Ser Gly Val Gly Asp Leu Ser Gly Leu Pro 
        915                 920                 925             


Ser Gly Glu Gly Leu Glu Val Ser Ala Ser Gly Val Glu Asp Leu Ser 
    930                 935                 940                 


Gly Leu Pro Ser Gly Glu Gly Pro Glu Thr Ser Thr Ser Gly Val Gly 
945                 950                 955                 960 


Asp Leu Ser Arg Leu Pro Ser Gly Glu Gly Pro Glu Val Ser Ala Ser 
                965                 970                 975     


Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Arg Glu Gly Leu Glu 
            980                 985                 990         


Thr Ser Thr Ser Gly Val Glu Asp  Leu Ser Gly Leu Pro  Ser Gly Glu 
        995                 1000                 1005             


Gly Pro  Glu Ala Ser Thr Ser  Gly Val Gly Asp Leu  Ser Arg Leu 
    1010                 1015                 1020             


Pro Ser  Gly Glu Gly Pro Glu  Val Ser Ala Ser Gly  Val Glu Asp 
    1025                 1030                 1035             


Leu Ser  Gly Leu Pro Ser Gly  Glu Gly Leu Glu Ala  Ser Ala Ser 
    1040                 1045                 1050             


Gly Val  Gly Asp Leu Ser Gly  Leu Pro Ser Gly Glu  Gly Pro Glu 
    1055                 1060                 1065             


Ala Ser  Ala Ser Gly Val Gly  Asp Leu Ser Arg Leu  Pro Ser Gly 
    1070                 1075                 1080             


Glu Gly  Pro Glu Val Ser Ala  Ser Gly Val Glu Asp  Leu Ser Gly 
    1085                 1090                 1095             


Leu Ser  Ser Gly Glu Ser Pro  Glu Ala Ser Ala Ser  Gly Val Gly 
    1100                 1105                 1110             


Asp Leu  Ser Gly Leu Pro Ser  Gly Arg Glu Gly Leu  Glu Thr Ser 
    1115                 1120                 1125             


Ala Ser  Gly Val Gly Asp Leu  Ser Gly Leu Pro Ser  Gly Glu Gly 
    1130                 1135                 1140             


Gln Glu  Ala Ser Ala Ser Gly  Val Glu Asp Leu Ser  Arg Leu Pro 
    1145                 1150                 1155             


Ser Gly  Glu Gly Pro Glu Ala  Ser Ala Ser Gly Val  Gly Glu Leu 
    1160                 1165                 1170             


Ser Gly  Leu Pro Ser Gly Arg  Glu Gly Leu Glu Thr  Ser Ala Ser 
    1175                 1180                 1185             


Gly Val  Gly Asp Leu Ser Gly  Leu Pro Ser Gly Glu  Gly Pro Glu 
    1190                 1195                 1200             


Ala Phe  Ala Ser Gly Val Glu  Asp Leu Ser Ile Leu  Pro Ser Gly 
    1205                 1210                 1215             


Glu Gly  Pro Glu Ala Ser Ala  Ser Gly Val Gly Asp  Leu Ser Gly 
    1220                 1225                 1230             


Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Thr Ser Thr  Ser Gly Val 
    1235                 1240                 1245             


Gly Asp  Leu Ser Gly Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Thr 
    1250                 1255                 1260             


Ser Thr  Ser Gly Val Gly Asp  Leu Ser Gly Leu Pro  Ser Gly Glu 
    1265                 1270                 1275             


Gly Pro  Glu Ala Ser Ala Ser  Gly Ile Gly Asp Ile  Ser Gly Leu 
    1280                 1285                 1290             


Pro Ser  Gly Arg Glu Gly Leu  Glu Thr Ser Ser Ser  Gly Val Glu 
    1295                 1300                 1305             


Asp His  Pro Glu Thr Ser Ala  Ser Gly Val Glu Asp  Leu Ser Gly 
    1310                 1315                 1320             


Leu Pro  Ser Gly Val Glu Gly  His Pro Glu Thr Ser  Ala Ser Gly 
    1325                 1330                 1335             


Val Glu  Asp Leu Ser Asp Leu  Ser Ser Gly Gly Glu  Gly Leu Glu 
    1340                 1345                 1350             


Thr Ser  Ala Ser Gly Ala Glu  Asp Leu Ser Gly Phe  Pro Ser Gly 
    1355                 1360                 1365             


Lys Glu  Asp Leu Ile Gly Ser  Ala Ser Gly Ala Leu  Asp Phe Gly 
    1370                 1375                 1380             


Arg Ile  Pro Ser Gly Thr Leu  Gly Ser Gly Gln Ala  Pro Glu Ala 
    1385                 1390                 1395             


Ser Ser  Leu Pro Ser Gly Phe  Ser Gly Glu Tyr Ser  Gly Val Asp 
    1400                 1405                 1410             


Phe Gly  Ser Gly Pro Ile Ser  Gly Leu Pro Asp Phe  Ser Gly Leu 
    1415                 1420                 1425             


Pro Ser  Gly Phe Pro Thr Ile  Ser Leu Val Asp Thr  Thr Leu Val 
    1430                 1435                 1440             


Glu Val  Ile Thr Thr Thr Ser  Ala Ser Glu Leu Glu  Gly Arg Gly 
    1445                 1450                 1455             


Thr Ile  Gly Ile Ser Gly Ala  Gly Glu Thr Ser Gly  Leu Pro Val 
    1460                 1465                 1470             


Ser Glu  Leu Asp Ile Ser Gly  Ala Val Ser Gly Leu  Pro Ser Gly 
    1475                 1480                 1485             


Ala Glu  Leu Ser Gly Gln Ala  Ser Gly Ser Pro Asp  Met Ser Gly 
    1490                 1495                 1500             


Glu Thr  Ser Gly Phe Phe Gly  Val Ser Gly Gln Pro  Ser Gly Phe 
    1505                 1510                 1515             


Pro Asp  Ile Ser Gly Gly Thr  Ser Gly Leu Phe Glu  Val Ser Gly 
    1520                 1525                 1530             


Gln Pro  Ser Gly Phe Ser Gly  Glu Thr Ser Gly Val  Thr Glu Leu 
    1535                 1540                 1545             


Ser Gly  Ser Gly Gln Pro Asp  Val Ser Gly Glu Ala  Ser Gly Val 
    1550                 1555                 1560             


Pro Ser  Gly Ser Gly Gln Pro  Phe Gly Met Thr Asp  Leu Ser Gly 
    1565                 1570                 1575             


Glu Thr  Ser Gly Val Pro Asp  Ile Ser Gly Gln Pro  Ser Gly Leu 
    1580                 1585                 1590             


Pro Glu  Phe Ser Gly Thr Thr  Ser Gly Ile Pro Asp  Leu Val Ser 
    1595                 1600                 1605             


Ser Thr  Met Ser Gly Ser Gly  Glu Ser Ser Gly Ile  Thr Phe Val 
    1610                 1615                 1620             


Asp Thr  Ser Leu Val Glu Val  Thr Pro Thr Thr Phe  Lys Glu Lys 
    1625                 1630                 1635             


Lys Arg  Leu Gly Ser Val Glu  Leu Ser Gly Leu Pro  Ser Gly Glu 
    1640                 1645                 1650             


Val Asp  Leu Ser Gly Ala Ser  Gly Thr Met Asp Ile  Ser Gly Gln 
    1655                 1660                 1665             


Ser Ser  Gly Ala Thr Asp Ser  Ser Gly Leu Thr Ser  His Leu Pro 
    1670                 1675                 1680             


Lys Phe  Ser Gly Leu Pro Ser  Gly Ala Ala Glu Val  Ser Gly Glu 
    1685                 1690                 1695             


Ser Ser  Gly Ala Glu Val Gly  Ser Ser Leu Pro Ser  Gly Thr Tyr 
    1700                 1705                 1710             


Glu Gly  Ser Gly Asn Phe His  Pro Ala Phe Pro Thr  Val Phe Leu 
    1715                 1720                 1725             


Val Asp  Arg Thr Leu Val Glu  Ser Val Thr Gln Ala  Pro Thr Ala 
    1730                 1735                 1740             


Gln Glu  Ala Gly Glu Gly Pro  Ser Gly Ile Leu Ser  Gly Ala His 
    1745                 1750                 1755             


Ser Gly  Ala Pro Asp Val Ser  Gly Asp His Ser Gly  Ser Leu Asp 
    1760                 1765                 1770             


Leu Ser  Gly Met Gln Ser Gly  Leu Val Glu Pro Ser  Gly Glu Pro 
    1775                 1780                 1785             


Ser Ser  Thr Pro Tyr Phe Ser  Gly Asp Phe Ser Gly  Thr Met Asp 
    1790                 1795                 1800             


Val Thr  Gly Glu Pro Ser Thr  Ala Met Ser Ala Ser  Gly Glu Ala 
    1805                 1810                 1815             


Ser Gly  Leu Leu Glu Val Thr  Leu Ile Thr Ser Glu  Phe Val Glu 
    1820                 1825                 1830             


Gly Val  Thr Glu Pro Thr Val  Ser Gln Glu Leu Ala  Gln Arg Pro 
    1835                 1840                 1845             


Pro Val  Thr His Thr Pro Gln  Leu Phe Glu Ser Ser  Gly Glu Ala 
    1850                 1855                 1860             


Ser Ala  Ser Gly Glu Ile Ser  Gly Ala Thr Pro Ala  Phe Pro Gly 
    1865                 1870                 1875             


Ser Gly  Leu Glu Ala Ser Ser  Val Pro Glu Ser Ser  Ser Glu Thr 
    1880                 1885                 1890             


Ser Asp  Phe Pro Glu Arg Ala  Val Gly Val Ser Ala  Ala Pro Glu 
    1895                 1900                 1905             


Ala Ser  Gly Gly Ala Ser Gly  Ala Pro Asp Val Ser  Glu Ala Thr 
    1910                 1915                 1920             


Ser Thr  Phe Pro Glu Ala Asp  Val Glu Gly Ala Ser  Gly Leu Gly 
    1925                 1930                 1935             


Val Ser  Gly Gly Thr Ser Ala  Phe Pro Glu Ala Pro  Arg Glu Gly 
    1940                 1945                 1950             


Ser Ala  Thr Pro Glu Val Gln  Glu Glu Pro Thr Thr  Ser Tyr Asp 
    1955                 1960                 1965             


Val Gly  Arg Glu Ala Leu Gly  Trp Pro Ser Ala Thr  Pro Thr Ala 
    1970                 1975                 1980             


Ser Gly  Asp Arg Ile Glu Val  Ser Gly Asp Leu Ser  Gly His Thr 
    1985                 1990                 1995             


Ser Gly  Leu Asp Val Val Ile  Ser Thr Ser Val Pro  Glu Ser Glu 
    2000                 2005                 2010             


Trp Ile  Gln Gln Thr Gln Arg  Pro Ala Glu Ala His  Leu Glu Ile 
    2015                 2020                 2025             


Glu Ala  Ser Ser Pro Leu His  Ser Gly Glu Glu Thr  Gln Thr Ala 
    2030                 2035                 2040             


Glu Thr  Ala Thr Ser Pro Thr  Asp Asp Ala Ser Ile  Pro Thr Ser 
    2045                 2050                 2055             


Pro Ser  Gly Thr Asp Glu Ser  Ala Pro Ala Ile Pro  Asp Ile Asp 
    2060                 2065                 2070             


Glu Cys  Leu Ser Ser Pro Cys  Leu Asn Gly Ala Thr  Cys Val Asp 
    2075                 2080                 2085             


Ala Ile  Asp Ser Phe Thr Cys  Leu Cys Leu Pro Ser  Tyr Arg Gly 
    2090                 2095                 2100             


Asp Leu  Cys Glu Ile Asp Gln  Glu Leu Cys Glu Glu  Gly Trp Thr 
    2105                 2110                 2115             


Lys Phe  Gln Gly His Cys Tyr  Arg Tyr Phe Pro Asp  Arg Glu Ser 
    2120                 2125                 2130             


Trp Val  Asp Ala Glu Ser Arg  Cys Arg Ala Gln Gln  Ser His Leu 
    2135                 2140                 2145             


Ser Ser  Ile Val Thr Pro Glu  Glu Gln Glu Phe Val  Asn Asn Asn 
    2150                 2155                 2160             


Ala Gln  Asp Tyr Gln Trp Ile  Gln Asp Arg Thr Ile  Glu Gly Asp 
    2165                 2170                 2175             


Phe Arg  Trp Ser Asp Gly His  Ser Leu Gln Phe Glu  Asn Trp Arg 
    2180                 2185                 2190             


Pro Asn  Gln Pro Asp Asn Phe  Phe Val Ser Gly Glu  Asp Cys Val 
    2195                 2200                 2205             


Val Met  Ile Trp His Glu Lys  Gly Glu Trp Asn Asp  Val Pro Cys 
    2210                 2215                 2220             


Asn Tyr  Tyr Leu Pro Phe Thr  Cys Lys Lys Gly Thr  Val Ala Cys 
    2225                 2230                 2235             


Gly Asp  Pro Pro Val Val Glu  His Ala Arg Thr Phe  Gly Gln Lys 
    2240                 2245                 2250             


Lys Asp  Arg Tyr Glu Ile Asn  Ser Leu Val Arg Tyr  Gln Cys Thr 
    2255                 2260                 2265             


Glu Gly  Phe Val Gln Arg His  Val Pro Thr Ile Arg  Cys Gln Pro 
    2270                 2275                 2280             


Ser Gly  His Trp Glu Lys Pro  Arg Ile Thr Cys Thr  Asp Pro Ser 
    2285                 2290                 2295             


Thr Tyr  Lys Arg Arg Leu Gln  Lys Arg Ser Ser Arg  Ala Pro Arg 
    2300                 2305                 2310             


Arg Ser  Arg Pro Ser Thr Ala  His 
    2315                 2320     


<210>  127
<211>  518
<212>  PRT
<213>  Dog

<400>  127

Tyr Glu Val Ser Val Tyr Ala Leu Lys Asp Thr Leu Thr Ser Arg Pro 
1               5                   10                  15      


Ala Gln Gly Val Val Thr Thr Leu Glu Asn Val Ser Pro Pro Arg Arg 
            20                  25                  30          


Ala Arg Val Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile Ser Trp Arg 
        35                  40                  45              


Thr Lys Thr Glu Thr Ile Thr Gly Phe Gln Val Asp Ala Ile Pro Ala 
    50                  55                  60                  


Asn Gly Gln Asn Pro Ile Gln Arg Thr Ile Arg Pro Asp Val Arg Ser 
65                  70                  75                  80  


Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp Tyr Lys Ile Tyr Leu 
                85                  90                  95      


Tyr Thr Leu Asn Asp Asn Ala Arg Ser Ser Pro Val Val Ile Asp Ala 
            100                 105                 110         


Ser Thr Ala Ile Asp Ala Pro Ser Asn Leu Arg Phe Leu Ala Thr Thr 
        115                 120                 125             


Pro Asn Ser Leu Leu Val Ser Trp Gln Pro Pro Arg Ala Arg Ile Thr 
    130                 135                 140                 


Gly Tyr Ile Ile Lys Tyr Glu Lys Pro Gly Ser Pro Pro Arg Glu Val 
145                 150                 155                 160 


Val Pro Arg Pro Arg Pro Gly Val Thr Glu Ala Thr Ile Thr Gly Leu 
                165                 170                 175     


Glu Pro Gly Thr Glu Tyr Thr Ile Gln Val Ile Ala Leu Lys Asn Asn 
            180                 185                 190         


Gln Lys Ser Glu Pro Leu Ile Gly Arg Lys Lys Thr Asp Glu Leu Pro 
        195                 200                 205             


Gln Leu Val Thr Leu Pro His Pro Asn Leu His Gly Pro Glu Ile Leu 
    210                 215                 220                 


Asp Val Pro Ser Thr Val Gln Lys Thr Pro Phe Ile Thr Asn Pro Gly 
225                 230                 235                 240 


Tyr Asp Thr Gly Asn Gly Ile Gln Leu Pro Gly Thr Ser Gly Gln Gln 
                245                 250                 255     


Pro Ser Val Gly Gln Gln Met Ile Phe Glu Glu His Gly Phe Arg Arg 
            260                 265                 270         


Thr Thr Pro Pro Thr Thr Ala Thr Pro Val Arg His Arg Pro Arg Pro 
        275                 280                 285             


Tyr Pro Pro Asn Val Asn Glu Glu Ile Gln Val Gly His Val Pro Arg 
    290                 295                 300                 


Gly Asp Val Asp His His Leu Tyr Pro His Val Met Gln Pro Asn Ala 
305                 310                 315                 320 


Ser Thr Gly Gln Glu Ala Leu Ser Gln Thr Thr Ile Ser Trp Thr Pro 
                325                 330                 335     


Phe Gln Glu Ser Ser Glu Tyr Ile Ile Ser Cys His Pro Val Gly Ile 
            340                 345                 350         


Asp Glu Glu Pro Leu Gln Phe Arg Val Pro Gly Thr Ser Ala Ser Ala 
        355                 360                 365             


Thr Leu Thr Gly Leu Thr Arg Gly Ala Thr Tyr Asn Ile Ile Val Glu 
    370                 375                 380                 


Ala Leu Lys Asp Gln Lys Arg His Lys Val Arg Glu Glu Val Val Thr 
385                 390                 395                 400 


Val Gly Asn Ser Val Asp Gln Gly Leu Asn Gln Pro Thr Asp Asp Ser 
                405                 410                 415     


Cys Phe Asp Pro Tyr Thr Val Ser His Tyr Ala Ile Gly Glu Glu Trp 
            420                 425                 430         


Glu Arg Leu Ser Glu Ser Gly Phe Lys Leu Ser Cys Gln Cys Leu Gly 
        435                 440                 445             


Phe Gly Ser Gly His Phe Arg Cys Asp Ser Ser Lys Trp Cys His Asp 
    450                 455                 460                 


Asn Gly Val Asn Tyr Lys Ile Gly Glu Lys Trp Asp Arg Gln Gly Glu 
465                 470                 475                 480 


Asn Gly Gln Met Met Ser Cys Thr Cys Leu Gly Asn Gly Lys Gly Glu 
                485                 490                 495     


Phe Lys Cys Asp Phe Ala Thr Cys Tyr Asp Asp Gly Lys Thr Tyr His 
            500                 505                 510         


Val Gly Glu His Trp Gln 
        515             


<210>  128
<211>  700
<212>  PRT
<213>  Dog

<400>  128

Met Ser Pro Arg Gln Pro Leu Val Leu Val Phe Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Ser Ala Ala Pro Arg Pro His Lys Pro Thr Val Val Val Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Lys Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Phe Arg Tyr Gly Tyr Thr Gln Val Ala Glu Leu Ser Asn Asp Lys 
    50                  55                  60                  


Gln Ser Leu Ser Arg Gly Leu Arg Leu Leu Gln Arg Arg Leu Ala Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Lys Thr Thr Leu Glu Ala Met Arg Ala 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Lys Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His Asn Asp Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Asp Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Val Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Gly Pro Glu Ala Asp Ile Ile Ile Gln Phe Gly Val Arg Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asn Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Glu Glu 
        195                 200                 205             


Leu Trp Thr Leu Gly Lys Gly Val Val Val Pro Thr His Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Pro Cys His Phe Pro Phe Thr Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Asp Thr Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asp Tyr Asp Thr Asp Arg Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Lys Leu Tyr Ala Gln Asp Gly Asn Gly Asp Gly Lys Pro Cys 
        275                 280                 285             


Val Phe Pro Phe Thr Phe Glu Gly Arg Ser Tyr Ser Thr Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ser Thr Thr Ala Asp Tyr 
305                 310                 315                 320 


Asp Gln Asp Lys Leu Tyr Gly Phe Cys Pro Thr Arg Val Asp Ser Ala 
                325                 330                 335     


Val Thr Gly Gly Asn Ser Ala Gly Glu Pro Cys Val Phe Pro Phe Ile 
            340                 345                 350         


Phe Leu Gly Lys Gln Tyr Ser Thr Cys Thr Arg Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly His Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Arg Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Ser Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Glu Asp Asp Val Arg Gly Ile Gln His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Gln Pro Pro Thr Ala Pro Pro Thr Ala Pro Pro Thr Val 
    450                 455                 460                 


Cys Ala Thr Gly Pro Pro Thr Trp Ser Pro Thr Ala Gly Pro Thr Gly 
465                 470                 475                 480 


Pro Pro Ala Ala Gly Pro Thr Gly Pro Pro Thr Ala Gly Pro Ser Glu 
                485                 490                 495     


Ala Pro Thr Val Pro Val Asp Pro Ala Glu Asp Ile Cys Lys Val Asn 
            500                 505                 510         


Ile Phe Asp Ala Ile Ala Glu Ile Arg Asn Tyr Leu His Phe Phe Lys 
        515                 520                 525             


Glu Gly Lys Tyr Trp Arg Phe Ser Lys Gly Lys Gly Arg Arg Val Gln 
    530                 535                 540                 


Gly Pro Phe Leu Ser Pro Ser Thr Trp Pro Ala Leu Pro Arg Lys Leu 
545                 550                 555                 560 


Asp Ser Ala Phe Glu Asp Gly Leu Thr Lys Lys Thr Phe Phe Phe Ser 
                565                 570                 575     


Gly Arg Gln Val Trp Val Tyr Thr Gly Thr Ser Val Val Gly Pro Arg 
            580                 585                 590         


Arg Leu Asp Lys Leu Gly Leu Gly Pro Glu Val Thr Gln Val Thr Gly 
        595                 600                 605             


Ala Leu Pro Gln Gly Gly Gly Lys Val Leu Leu Phe Ser Arg Gln Arg 
    610                 615                 620                 


Phe Trp Ser Phe Asp Val Lys Thr Gln Thr Val Asp Pro Arg Ser Ala 
625                 630                 635                 640 


Gly Ser Val Glu Gln Met Tyr Pro Gly Val Pro Leu Asn Thr His Asp 
                645                 650                 655     


Ile Phe Gln Tyr Gln Glu Lys Ala Tyr Phe Cys Gln Asp Arg Phe Tyr 
            660                 665                 670         


Trp Arg Val Asn Ser Arg Asn Glu Val Asn Gln Val Asp Glu Val Gly 
        675                 680                 685             


Tyr Val Thr Phe Asp Ile Leu Gln Cys Pro Glu Asp 
    690                 695                 700 


<210>  129
<211>  478
<212>  PRT
<213>  Dog

<400>  129

Met Gln Asn Leu Pro Ala Leu Leu Leu Phe Cys Gly Val Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Val Asp Arg Ala Ala Glu Asp Glu Asn Asn Asn Met Glu 
            20                  25                  30          


Leu Thr Gln Gln Tyr Leu Glu Asn Tyr Tyr Asn Leu Gly Lys Asp Val 
        35                  40                  45              


Lys Pro Phe Val Arg Arg Arg Asn Ser Gly Pro Val Val Glu Lys Ile 
    50                  55                  60                  


Arg Glu Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Val Asp 
65                  70                  75                  80  


Ser Asp Thr Leu Ala Met Met Arg Arg Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Gly Asp Phe Thr Thr Phe Pro Gly Met Pro Lys Trp Arg Lys Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Met Asn Tyr Thr Pro Asp Leu Pro Arg Asp 
        115                 120                 125             


Ala Val Asp Ser Ala Ile Glu Lys Ala Leu Asn Val Trp Lys Glu Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Ser Arg Thr Asp Glu Gly Glu Ala Asp Ile Lys 
145                 150                 155                 160 


Ile Ser Phe Ala Val Arg Asp His Gly Asp Phe Asn Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Asn Val Leu Gly His Ala Tyr Pro Pro Gly Pro Gly Ile Tyr 
            180                 185                 190         


Gly Asp Ala His Phe Asp Asp Asp Glu Gln Trp Thr Ser Asp Thr Ser 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Val Ala Ala His Glu Leu Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Phe His Ser Ala Asp Pro Ser Ala Leu Met Tyr Pro Val Tyr 
225                 230                 235                 240 


Asn Val Leu Ala Asp Leu Ala Arg Phe His Leu Ser Gln Asp Asp Val 
                245                 250                 255     


Asn Gly Ile Gln Ser Leu Tyr Gly Gly Pro Pro Ser Asp Ser Ser Asn 
            260                 265                 270         


Asp Pro Val Val Pro Thr Glu Ser Val Pro Pro Gly Pro Gly Thr Pro 
        275                 280                 285             


Ala Ala Cys Asp Pro Thr Leu Ser Phe Asp Ala Ile Ser Thr Leu Arg 
    290                 295                 300                 


Gly Glu Phe Leu Phe Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu 
305                 310                 315                 320 


Arg Thr Leu Glu Pro Gly Phe Tyr Leu Ile Ser Ser Phe Trp Pro Ser 
                325                 330                 335     


Leu Pro Ser Gly Leu Asp Ala Ala Tyr Glu Glu Thr Ser Lys Asp Ile 
            340                 345                 350         


Val Phe Ile Phe Lys Gly Asn Gln Phe Trp Ala Met Arg Gly Thr Glu 
        355                 360                 365             


Val Gln Ala Gly Tyr Pro Lys Gly Ile His Thr Leu Gly Phe Pro Pro 
    370                 375                 380                 


Thr Val Lys Lys Ile Asp Ala Ala Val Phe Asp Lys Glu Lys Lys Lys 
385                 390                 395                 400 


Thr Tyr Phe Phe Val Gly Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg 
                405                 410                 415     


Gln Ser Met Glu Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro 
            420                 425                 430         


Gly Val Asp Ser Lys Val Asp Ala Ala Phe Glu Ala Phe Gly Phe Tyr 
        435                 440                 445             


Tyr Phe Phe Asn Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys 
    450                 455                 460                 


Lys Val Thr His Val Leu Lys Ser Asn Ser Trp Leu Asn Cys 
465                 470                 475             


<210>  130
<211>  445
<212>  PRT
<213>  Dog

<400>  130

Val Arg Arg Gly Pro Gln Pro Trp His Glu Ala Gly Pro Ser Ser Leu 
1               5                   10                  15      


Val Pro Ala Pro Thr Ala Gln Asp Thr Pro Gln Pro Ala Ser Ser Pro 
            20                  25                  30          


Arg Pro Pro Arg Cys Gly Val Pro Asp Pro Pro Asp Gly Leu Ser Ala 
        35                  40                  45              


Arg Asn Arg Gln Lys Arg Phe Val Leu Ser Gly Gly Arg Trp Asp Lys 
    50                  55                  60                  


Thr Asp Leu Thr Tyr Arg Ile Leu Arg Phe Pro Trp Gln Leu Val Arg 
65                  70                  75                  80  


Glu Gln Val Arg Gln Thr Val Ala Glu Ala Leu Gln Val Trp Ser Glu 
                85                  90                  95      


Val Thr Pro Leu Thr Phe Thr Glu Val His Glu Gly Arg Ala Asp Ile 
            100                 105                 110         


Met Ile Asp Phe Thr Arg Tyr Trp His Gly Asp Asn Leu Pro Phe Asp 
        115                 120                 125             


Gly Pro Gly Gly Ile Leu Ala His Ala Phe Phe Pro Lys Thr His Arg 
    130                 135                 140                 


Glu Gly Asp Val His Phe Asp Tyr Asp Glu Thr Trp Thr Ile Gly Asn 
145                 150                 155                 160 


Asn Gln Gly Thr Asp Leu Leu Gln Val Ala Ala His Glu Phe Gly His 
                165                 170                 175     


Thr Leu Gly Leu Gln His Thr Thr Ala Ala Lys Ala Leu Met Ser Pro 
            180                 185                 190         


Phe Tyr Thr Phe Arg Tyr Pro Leu Ser Leu Ser Pro Asp Asp Arg Arg 
        195                 200                 205             


Gly Ile Gln His Leu Tyr Gly Gln Pro Arg Thr Ala Pro Thr Ser Arg 
    210                 215                 220                 


Pro Pro Ala Val Gly Pro Gln Ala Gly Val Asp Thr Asn Glu Ile Ala 
225                 230                 235                 240 


Pro Leu Glu Pro Glu Ala Pro Pro Asp Ala Cys Glu Ile Thr Phe Asp 
                245                 250                 255     


Ala Val Ser Thr Ile Arg Gly Glu Leu Phe Phe Phe Lys Ala Gly Phe 
            260                 265                 270         


Val Trp Arg Leu Arg Gly Gly Arg Leu Gln Pro Gly Tyr Pro Ala Leu 
        275                 280                 285             


Ala Ser Arg His Trp Gln Gly Leu Pro Ser Pro Val Asp Ala Ala Phe 
    290                 295                 300                 


Glu Asp Ala Gln Gly His Ile Trp Phe Phe Gln Gly Ala Gln Tyr Trp 
305                 310                 315                 320 


Val Tyr Asn Gly Glu Lys Pro Val Leu Gly Pro Ala Pro Leu Ser Glu 
                325                 330                 335     


Leu Gly Leu Leu Gly Ser Pro Ile Gln Ala Ala Leu Ala Trp Gly Pro 
            340                 345                 350         


Glu Lys Asn Lys Ile Tyr Phe Phe Gly Gly Arg Asp Tyr Trp Arg Phe 
        355                 360                 365             


His Leu Ser Thr Arg Arg Val Asp Ser Pro Val Pro Arg Arg Ala Thr 
    370                 375                 380                 


Asp Trp Arg Gly Val Pro Ser Glu Ile Asp Ala Ala Phe Arg Asp Ala 
385                 390                 395                 400 


Asp Gly Tyr Ala Tyr Phe Leu Arg Gly Arg Leu Tyr Trp Lys Phe Asp 
                405                 410                 415     


Pro Val Lys Val Lys Ala Leu Glu Gly Phe Pro Arg Leu Val Gly Pro 
            420                 425                 430         


Asp Phe Phe Gly Cys Thr Glu Pro Ala Asn Thr Phe Arg 
        435                 440                 445 


<210>  131
<211>  582
<212>  PRT
<213>  Dog

<400>  131

Met Ser Pro Ala Pro Arg Pro Ala Gly Gly Arg Leu Leu Pro Leu Leu 
1               5                   10                  15      


Thr Leu Ala Thr Ala Leu Ala Ser Leu Ser Ser Ala Gln Ser Ser Phe 
            20                  25                  30          


Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly Asp 
        35                  40                  45              


Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Phe Ser Ala Ala Ile 
    50                  55                  60                  


Ala Ala Met Gln Lys Phe Tyr Gly Leu Arg Val Thr Gly Lys Ala Asp 
65                  70                  75                  80  


Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr Ala 
            100                 105                 110         


Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile Gln 
        115                 120                 125             


Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Phe Glu Ala Ile Arg 
    130                 135                 140                 


Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg Glu 
145                 150                 155                 160 


Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp Ile 
                165                 170                 175     


Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe Asp 
            180                 185                 190         


Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn Ile 
        195                 200                 205             


Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg Asn 
    210                 215                 220                 


Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu Leu 
225                 230                 235                 240 


Gly His Ala Leu Gly Leu Glu His Ser Asn Asp Pro Ser Ala Ile Met 
                245                 250                 255     


Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro Asp 
            260                 265                 270         


Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Ser Glu Ser Gly Ser 
        275                 280                 285             


Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser Val 
    290                 295                 300                 


Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp Gly 
305                 310                 315                 320 


Asn Phe Asp Thr Val Ala Val Leu Arg Gly Glu Met Phe Val Phe Lys 
                325                 330                 335     


Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly Tyr 
            340                 345                 350         


Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile Asn 
        355                 360                 365             


Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly Asp 
    370                 375                 380                 


Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro Lys 
385                 390                 395                 400 


His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp Ala 
                405                 410                 415     


Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly Asn 
            420                 425                 430         


Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu Tyr 
        435                 440                 445             


Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg Gly 
    450                 455                 460                 


Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly Asn 
465                 470                 475                 480 


Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly Tyr 
                485                 490                 495     


Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Ser Gly Ser 
            500                 505                 510         


Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu 
        515                 520                 525             


Val Asp Glu Glu Gly Ser Gly Ala Val Ser Ala Ala Ala Val Val Leu 
    530                 535                 540                 


Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe 
545                 550                 555                 560 


Phe Phe Arg Arg His Gly Thr Pro Lys Arg Leu Leu Tyr Cys Gln Arg 
                565                 570                 575     


Ser Leu Leu Asp Lys Val 
            580         


<210>  132
<211>  261
<212>  PRT
<213>  Dog

<400>  132

Met Gln Ala Ala Ile Leu Lys Val Thr Val Phe Leu Pro Trp Cys Leu 
1               5                   10                  15      


Ala Phe Pro Val Pro Pro Ala Thr Asp Leu Lys Gly Leu Asp Phe Val 
            20                  25                  30          


Lys Asn Tyr Phe His Gln Leu Phe Leu Thr Lys Arg Glu Leu Pro Leu 
        35                  40                  45              


Phe Thr Gln Glu Asp Lys Ile Gln Arg Leu Lys Gln Phe His Leu Asn 
    50                  55                  60                  


Glu Thr Val Leu Gln Asp Glu Gln Met Leu Val Val Ser Arg Gln Pro 
65                  70                  75                  80  


His Cys Gly Gly Asn Asp Gly Ala Lys Asp Ser Thr Phe Pro Gly Ser 
                85                  90                  95      


Ser Met Trp Asp Lys His Thr Leu Thr Tyr Arg Ile Ile Asn Tyr Pro 
            100                 105                 110         


Arg Asp Ile Asn Pro Ser Thr Val Lys Asn Ile Met Gln Asn Ala Val 
        115                 120                 125             


Ser Ile Trp Ser Asn Val Thr Pro Leu Ile Phe Gln Gln Val Lys Ser 
    130                 135                 140                 


Gln Asp Ala Asp Ile Lys Ile Ser Phe Trp Asp Leu Ala His Gly Asp 
145                 150                 155                 160 


Cys Trp Pro Phe Asp Gly Pro Gly Gly Val Leu Gly His Ala Phe Leu 
                165                 170                 175     


Pro Asn Ser Arg Ala Pro Gly Val Ile His Phe Asp Arg Gly Glu His 
            180                 185                 190         


Trp Ser Thr Ser Tyr Arg Gly Phe Asn Leu Phe Leu Val Ala Ile His 
        195                 200                 205             


Glu Leu Gly His Ser Leu Gly Leu Leu His Ser Lys Ser Leu Asn Ser 
    210                 215                 220                 


Ile Met Tyr Pro Arg Tyr Val Asn Arg Asp Pro Arg Thr Phe His Leu 
225                 230                 235                 240 


Asp Gly Asp Asp Ile Lys Arg Ile Gln Gln Leu Tyr Gly Glu Arg Cys 
                245                 250                 255     


Ser Ser Glu Met Pro 
            260     


<210>  133
<211>  267
<212>  PRT
<213>  Dog

<400>  133

Met Trp Pro Ala Val Leu Cys Ala Leu Cys Leu Leu Pro Ser Cys Leu 
1               5                   10                  15      


Ala Leu Pro Leu Pro Arg Glu Ala Gly Gly Met Ser Glu Pro Gln Trp 
            20                  25                  30          


Lys Gln Ala Gln Asp Tyr Leu Lys Arg Phe Tyr Pro Ser Asp Ser Lys 
        35                  40                  45              


Thr Arg Asp Ala Asp Ser Phe Lys Thr Lys Leu Lys Glu Met Gln Lys 
    50                  55                  60                  


Phe Phe Arg Leu Pro Val Thr Gly Ile Leu Asn Ser Arg Thr Ile Glu 
65                  70                  75                  80  


Ile Met Gln Lys Pro Arg Cys Gly Val Pro Asp Val Ala His Phe Ser 
                85                  90                  95      


Leu Phe Pro Asn Arg Pro Lys Trp Thr Ser Glu Val Ile Thr Tyr Arg 
            100                 105                 110         


Ile Ala Ser Tyr Thr Pro Asp Leu Pro Arg Phe Arg Val Asn Gln Leu 
        115                 120                 125             


Val Ala Lys Ala Leu Ala Met Trp Ser Lys Glu Ile Pro Leu Ser Phe 
    130                 135                 140                 


Arg Arg Val Pro Arg Gly Thr Ala Asp Ile Met Ile Gly Phe Ala Arg 
145                 150                 155                 160 


Gly Ala His Gly Asp Tyr Tyr Pro Phe Asp Gly Pro Gly Asn Ile Leu 
                165                 170                 175     


Ala His Ala Phe Ala Pro Gly Pro Asp Leu Gly Gly Asp Ala His Phe 
            180                 185                 190         


Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Arg Ile Gly Ile Asn Phe 
        195                 200                 205             


Leu Ile Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Leu Gly His 
    210                 215                 220                 


Ser Ser Asp Pro Asp Ala Val Met Tyr Pro Thr Tyr Ser Ile Arg Asp 
225                 230                 235                 240 


Ser Lys Ser Phe Lys Leu Ser Gln Asp Asp Ile Glu Gly Ile Gln Lys 
                245                 250                 255     


Leu Tyr Val Leu Gln Asp Asn Pro Gln Gln Arg 
            260                 265         


<210>  134
<211>  423
<212>  PRT
<213>  Dog

<400>  134

Met Gln Arg Phe Gly Gly Leu Glu Ala Thr Gly Ile Leu Asp Val Ala 
1               5                   10                  15      


Thr Leu Ala Leu Met Lys Thr Pro Arg Cys Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Ala Ala Ala Pro Ala Arg Arg Arg Arg Gln Ala Pro Ala Pro Thr Thr 
        35                  40                  45              


Trp His Lys Arg Ser Leu Ser Trp Arg Val Arg Thr Phe Pro Arg Asp 
    50                  55                  60                  


Ser Pro Leu Gly Pro Asp Thr Val Arg Ala Leu Met His Tyr Ala Leu 
65                  70                  75                  80  


Lys Val Trp Ser Asp Ile Thr Pro Leu Asn Phe His Glu Val Ala Gly 
                85                  90                  95      


Ser Ala Ala Asp Ile Gln Ile Asp Phe Ser Lys Ala Asp His Asn Asp 
            100                 105                 110         


Ala Tyr Pro Phe Asp Gly Pro Gly Gly Thr Val Ala His Ala Phe Phe 
        115                 120                 125             


Pro Gly Asp His His Thr Ala Gly Asp Ala His Phe Asp Asp Asp Glu 
    130                 135                 140                 


Ser Trp Ala Phe Arg Ser Ser Asp Ala His Asp Met Asp Leu Phe Ala 
145                 150                 155                 160 


Val Ala Val His Glu Phe Gly His Ala Ile Gly Leu Ser His Val Ala 
                165                 170                 175     


Ala Thr Ser Ser Ile Met Gln Pro Tyr Tyr Gln Gly Pro Val Gly Asp 
            180                 185                 190         


Pro Leu His Tyr Arg Leu Pro Tyr Glu Asp Arg Val Arg Ile Trp Gln 
        195                 200                 205             


Leu Tyr Gly Glu Ser Phe Pro Ser Asn Leu Pro Leu Ser Pro Gln Asp 
    210                 215                 220                 


Val Pro His Arg Cys Ser Thr Asp Phe Asp Ala Val Ala Gln Ile Arg 
225                 230                 235                 240 


Gly Glu Ala Phe Phe Phe Lys Gly Lys Tyr Phe Trp Arg Leu Thr Arg 
                245                 250                 255     


Asp Gly His Leu Val Ser Leu Gln Pro Ala Gln Met His Arg Phe Trp 
            260                 265                 270         


Arg Gly Leu Pro Leu Gln Leu Asp Ser Val Asp Ala Val Tyr Glu Arg 
        275                 280                 285             


Thr Ser Asp His Lys Ile Val Phe Phe Lys Gly Asp Arg Tyr Trp Val 
    290                 295                 300                 


Phe Lys Asp Asn Asn Val Glu Glu Gly Tyr Pro Arg Pro Val Ser Asp 
305                 310                 315                 320 


Phe Gly Leu Pro Pro Gly Gly Val Asp Ala Ala Phe Ser Trp Ser His 
                325                 330                 335     


Asn Asp Lys Thr Tyr Phe Phe Lys Asp Gln Leu Tyr Trp Arg Phe Asp 
            340                 345                 350         


Glu His Thr Arg Arg Met Asp Pro Gly His Pro Ala Arg Ser Pro Pro 
        355                 360                 365             


Trp Arg Gly Ile Pro Ser Thr Leu Asp Asp Ala Met Cys Trp Ser Asp 
    370                 375                 380                 


Gly Ala Ala Tyr Phe Phe Arg Gly Lys Glu Tyr Trp Lys Val Leu Asp 
385                 390                 395                 400 


Ser Glu Leu Glu Val Ala Pro Gly Tyr Pro Gln Ser Thr Ala Arg Asp 
                405                 410                 415     


Trp Leu Val Cys Arg Asp Leu 
            420             


<210>  135
<211>  560
<212>  PRT
<213>  Dog

<400>  135

Met Leu Arg Leu Leu Val Leu Leu Leu Ser Val Leu Pro Pro Pro Ala 
1               5                   10                  15      


Arg Ala Arg Glu Pro Ser Ala Gln Asp Val Ser Leu Gly Val Asp Trp 
            20                  25                  30          


Leu Thr Arg Tyr Gly Tyr Leu Pro Ser Pro His Pro Ala Gln Ala Gln 
        35                  40                  45              


Leu Gln Ser Pro Thr Lys Leu Arg Asp Ala Ile Lys Val Met Gln Arg 
    50                  55                  60                  


Phe Ala Gly Leu Pro Glu Thr Gly Val Leu Asp Ser Ala Thr Met Ala 
65                  70                  75                  80  


Thr Met Gln Lys Pro Arg Cys Ser Leu Pro Asp Val Leu Gly Val Ala 
                85                  90                  95      


Glu Leu Val Arg Arg Arg Arg Arg Arg Arg Tyr Ala Leu Ser Gly Ser 
            100                 105                 110         


Met Trp Arg Lys Arg Thr Leu Thr Trp Arg Val Arg Ser Phe Pro Gln 
        115                 120                 125             


Ser Ser Ala Leu Thr Gln Glu Thr Val Arg Thr Leu Met His His Ala 
    130                 135                 140                 


Leu Thr Thr Trp Gly Val Glu Ser Gly Leu Ile Gln Glu Leu Val Ser 
145                 150                 155                 160 


Gln Ala Pro Thr Glu Pro Asp Ile Leu Ile Asp Phe Ala Arg Ala Tyr 
                165                 170                 175     


His Gln Asp Ser Tyr Pro Phe Asp Gly Gln Gly Gly Thr Leu Ala His 
            180                 185                 190         


Ala Phe Phe Pro Gly Glu His Pro Ile Ser Gly Asp Thr His Phe Asp 
        195                 200                 205             


Asp Glu Glu Thr Trp Thr Tyr Gly Ser Lys Asp Gly Glu Gly Thr Asp 
    210                 215                 220                 


Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala Leu Gly Leu Gly 
225                 230                 235                 240 


His Ser Ser Ala Pro Asn Ser Ile Met Arg Pro Phe Tyr Gln Gly Pro 
                245                 250                 255     


Val Gly Asp Pro His Glu Tyr Arg Leu Ser Asp Asp Asp Arg Glu Gly 
            260                 265                 270         


Leu Gln Gln Leu Tyr Gly Lys Val Pro Gln Thr Pro Tyr Asp Lys Pro 
        275                 280                 285             


Thr Arg Lys Pro Leu Ala Pro Pro Pro Pro Pro Pro Ala Leu Pro Pro 
    290                 295                 300                 


Asp Ser Pro Ser Leu Pro Ile Pro Asp Arg Cys Asp Gly Asn Phe Asp 
305                 310                 315                 320 


Ala Ile Ala Asn Ile Arg Gly Glu Ile Phe Phe Phe Lys Gly Pro Trp 
                325                 330                 335     


Phe Trp Arg Leu Gln Pro Ser Gly Gln Leu Val Ser Pro Arg Pro Ala 
            340                 345                 350         


Arg Leu His Arg Phe Trp Glu Gly Leu Pro Ala Ala Val Asp Val Val 
        355                 360                 365             


Gln Ala Ala Tyr Ala Arg His Pro Asp Gly Arg Ile Leu Leu Phe Ser 
    370                 375                 380                 


Gly Pro Arg Phe Trp Val Phe Arg Asp Arg Gln Leu Glu Gly Ala Pro 
385                 390                 395                 400 


Arg Pro Leu Lys Gly Leu Gly Leu Pro Ala Gly Glu Gln Gly Asp Pro 
                405                 410                 415     


Gln Phe Ser Trp Pro Leu Asn Gly Lys Thr His Leu Ile Arg Gly Arg 
            420                 425                 430         


Gly Tyr Trp Gly Tyr His Lys Ala Ala Ala Arg Ala Asp Pro Gly Tyr 
        435                 440                 445             


Pro Arg Asp Leu Ser Leu Trp Glu Gly Ala Pro His Ala Pro Asp Asp 
    450                 455                 460                 


Val Thr Val Ser Asn Thr Gly Asp Thr Tyr Phe Phe Lys Gly Ala His 
465                 470                 475                 480 


Tyr Trp Arg Phe Pro Lys Gly Ser Val Lys Ala Glu Pro Asp Ser Pro 
                485                 490                 495     


Gln Pro Met Gly Pro Lys Trp Leu Asp Cys Pro Ala Ala Ser Ala Asp 
            500                 505                 510         


Pro Arg Ala Pro Arg Pro Pro Arg Gly Thr Leu Ala Pro Gly Thr Cys 
        515                 520                 525             


Asp Cys His Cys Glu Ile Asn Gln Ala Ser Gly Arg Pro Ser Leu Ser 
    530                 535                 540                 


Leu Glu Val Ser Leu Leu Ala Leu Leu Leu Gly Gly Val Ala Ser Val 
545                 550                 555                 560 


<210>  136
<211>  531
<212>  PRT
<213>  Dog

<400>  136

Met Asn Trp Gln Trp Leu Cys Leu Gly Phe Leu Leu Pro Ala Thr Val 
1               5                   10                  15      


Ser Gly Arg Ala Leu Gly Thr Ala Arg Lys Glu Thr Ala Val Asp Tyr 
            20                  25                  30          


Leu Leu Gln Tyr Gly Tyr Leu Gln Lys Pro Leu Glu Gly Pro Asp Asn 
        35                  40                  45              


Phe Arg Pro Glu Asp Ile Met Glu Ala Leu Arg Thr Phe Gln Glu Ala 
    50                  55                  60                  


Ser Glu Leu Pro Val Ser Gly Gln Leu Asp Asp Ala Thr Arg Ala Arg 
65                  70                  75                  80  


Met Arg Gln Pro Arg Cys Gly Leu Glu Asp Pro Phe Asn Gln Lys Thr 
                85                  90                  95      


Leu Lys Tyr Leu Leu Leu Gly Arg Trp Arg Lys Lys His Leu Thr Phe 
            100                 105                 110         


Arg Ile Phe Asn Leu Pro Ser Thr Leu Pro Pro Asp Thr Ala Arg Ala 
        115                 120                 125             


Ala Leu Leu Gln Ala Phe Gln Tyr Trp Ser Ser Ala Ala Pro Leu Thr 
    130                 135                 140                 


Phe Arg Glu Val Gln Ala Gly Trp Ala Asp Ile Arg Leu Ser Phe His 
145                 150                 155                 160 


Gly Arg Gln Ser Pro Tyr Cys Ser Asn Ser Phe Asp Gly Pro Gly Arg 
                165                 170                 175     


Val Leu Ala His Ala Asp Ile Pro Glu Leu Gly Ser Val His Phe Asp 
            180                 185                 190         


Glu Asp Glu Leu Trp Thr Glu Arg Thr Tyr Arg Gly Val Asn Leu Arg 
        195                 200                 205             


Ile Ile Ala Ala His Glu Leu Gly His Ala Leu Gly Leu Gly His Ser 
    210                 215                 220                 


Arg Tyr Thr Gln Ala Leu Met Ala Pro Val Tyr Ala Gly Tyr Arg Pro 
225                 230                 235                 240 


His Phe Lys Leu His Pro Asp Asp Val Ala Gly Ile Gln Ala Leu Tyr 
                245                 250                 255     


Gly Lys Lys Ser Pro Glu Thr Glu Glu Glu Glu Glu Glu Met Glu Leu 
            260                 265                 270         


Pro Ala Ile Pro His Met Pro Thr Glu Pro Gly Pro Met Pro Asp Pro 
        275                 280                 285             


Cys Ser Gly Glu Leu Asp Ala Ile Met Leu Gly Pro Arg Gly Lys Thr 
    290                 295                 300                 


Tyr Ala Phe Lys Gly Asn Tyr Val Trp Thr Val Thr Asp Ser Gly Leu 
305                 310                 315                 320 


Gly Pro Leu Phe Gln Val Ser Ala Leu Trp Glu Gly Leu Pro Gly Asn 
                325                 330                 335     


Leu Asp Ala Ala Val Tyr Ser Pro Arg Thr Gln Trp Ile His Phe Phe 
            340                 345                 350         


Lys Gly Asp Lys Val Trp Arg Tyr Ile Asn Phe Lys Arg Ser Pro Gly 
        355                 360                 365             


Phe Pro Lys Lys Leu Asn Arg Ile Glu Pro Asn Leu Asp Ala Ala Leu 
    370                 375                 380                 


Tyr Trp Pro Phe Asn Gln Lys Val Phe Leu Phe Lys Gly Ser Gly Tyr 
385                 390                 395                 400 


Trp Gln Trp Asp Glu Leu Ala Arg Thr Asp Phe Ser His Tyr Pro Lys 
                405                 410                 415     


Pro Ile Lys Arg Leu Phe Thr Gly Val Pro Asp Gln Pro Ser Ala Ala 
            420                 425                 430         


Val Ser Trp Arg Asp Gly Arg Val Tyr Phe Phe Lys Asp Lys Gln Tyr 
        435                 440                 445             


Trp Arg Leu Asn Arg Gln Leu Arg Val Glu Lys Gly Tyr Pro Arg Asp 
    450                 455                 460                 


Thr Ala Pro Asn Trp Met His Cys His Pro Gln Thr Ser Asp Pro Pro 
465                 470                 475                 480 


Pro Ser Gly Gly Asp Ile Arg Pro Ser Ala Thr Ala Ile Asp Thr Thr 
                485                 490                 495     


Leu Asn Asn Asp Pro Ser Pro Gly Asp Pro Ile Leu Asp Ile Thr Pro 
            500                 505                 510         


Ser Ala Thr Ala Ser Pro Thr Leu Ser Phe Pro Gly Thr Val Thr Leu 
        515                 520                 525             


Pro Glu Ala 
    530     


<210>  137
<211>  632
<212>  PRT
<213>  Dog

<400>  137

Ala Ala Pro Ser Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys 
1               5                   10                  15      


Thr Asp Lys Glu Leu Ala Val Gln Tyr Leu Asn Thr Tyr Tyr Gly Cys 
            20                  25                  30          


Pro Lys Glu Arg Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys 
        35                  40                  45              


Met Gln Lys Phe Phe Gly Leu Pro Gln Thr Gly Glu Leu Asp Gln Ser 
    50                  55                  60                  


Thr Ile Glu Thr Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala 
65                  70                  75                  80  


Asn Tyr Asn Phe Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile 
                85                  90                  95      


Thr Tyr Arg Ile Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val 
            100                 105                 110         


Asp Asp Ala Phe Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro 
        115                 120                 125             


Leu Arg Phe Ser Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn 
    130                 135                 140                 


Phe Gly Arg Trp Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp 
145                 150                 155                 160 


Gly Leu Leu Ala His Ala Phe Ala Pro Gly Pro Gly Val Gly Gly Asp 
                165                 170                 175     


Ser His Phe Asp Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val 
            180                 185                 190         


Val Arg Val Lys Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro 
        195                 200                 205             


Phe Leu Phe Asn Gly Arg Glu Tyr Thr Ser Cys Thr Asp Thr Gly Arg 
    210                 215                 220                 


Ser Asp Gly Phe Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp 
225                 230                 235                 240 


Gly Lys Tyr Gly Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly 
                245                 250                 255     


Asn Ala Asp Gly Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr 
            260                 265                 270         


Ser Tyr Asp Ser Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp 
        275                 280                 285             


Cys Gly Thr Thr Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys 
    290                 295                 300                 


Pro Glu Thr Ala Met Ser Thr Ile Gly Gly Asn Ser Glu Gly Ala Pro 
305                 310                 315                 320 


Cys Val Phe Pro Phe Thr Phe Leu Gly Asn Lys His Glu Ser Cys Thr 
                325                 330                 335     


Ser Ala Gly Arg Ser Asp Gly Lys Val Trp Cys Ala Thr Thr Ala Asn 
            340                 345                 350         


Tyr Asp Asp Asp Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser 
        355                 360                 365             


Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu 
    370                 375                 380                 


His Ser Glu Asp Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr 
385                 390                 395                 400 


Lys Asn Phe Arg Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu 
                405                 410                 415     


Tyr Gly Ala Ser Pro Asp Ala Gly Thr Gly Thr Gly Pro Thr Pro Thr 
            420                 425                 430         


Leu Gly Pro Val Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp 
        435                 440                 445             


Gly Ile Ser Gln Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe 
    450                 455                 460                 


Ile Trp Arg Thr Val Thr Pro Arg Asn Lys Pro Met Gly Pro Leu Leu 
465                 470                 475                 480 


Val Ala Thr Phe Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr 
                485                 490                 495     


Glu Ala Pro Gln Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr 
            500                 505                 510         


Trp Val Tyr Ser Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu 
        515                 520                 525             


Thr Ser Leu Gly Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe 
    530                 535                 540                 


Asn Trp Ser Lys Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe 
545                 550                 555                 560 


Trp Arg Tyr Asn Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys 
                565                 570                 575     


Leu Ile Ala Asp Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val 
            580                 585                 590         


Val Asp Leu Gln Gly Ser Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr 
        595                 600                 605             


Tyr Leu Lys Leu Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser 
    610                 615                 620                 


Ile Lys Ser Asp Trp Leu Gly Cys 
625                 630         


<210>  138
<211>  512
<212>  PRT
<213>  Dog

<400>  138

Met Lys Ser Leu Leu Leu Gln Phe Phe Leu Phe Ile Thr Phe Ser Ser 
1               5                   10                  15      


Ala Phe Pro Thr Glu Gln Lys Met Asp Thr Glu Glu Asn Met Gln Leu 
            20                  25                  30          


Ala Gln Val Tyr Leu Asn Gln Phe Tyr Ser Leu Glu Ile Glu Gly Ser 
        35                  40                  45              


His Leu Ala Gln Ser Lys Asn Lys Ser Leu Leu Val Gly Lys Ile Arg 
    50                  55                  60                  


Glu Met Gln Ala Phe Phe Gly Leu Thr Val Thr Gly Gln Leu Asp Ser 
65                  70                  75                  80  


Asn Thr Leu Glu Ile Met Lys Thr Pro Arg Cys Gly Val Pro Asp Val 
                85                  90                  95      


Gly Gln Tyr Gly Tyr Thr Leu Pro Gly Trp Arg Lys Tyr Asn Leu Thr 
            100                 105                 110         


Tyr Arg Ile Val Asn Tyr Thr Pro Asp Met Ala Arg Val Asp Val Asp 
        115                 120                 125             


Lys Ala Ile Gln Asn Gly Leu Glu Val Trp Ser Gly Val Thr Pro Leu 
    130                 135                 140                 


Thr Phe Thr Lys Ile Ser Lys Gly Ile Ala Asp Ile Met Ile Ala Phe 
145                 150                 155                 160 


Arg Thr Arg Val His Gly Trp Cys Pro Arg Tyr Phe Asp Gly Pro Leu 
                165                 170                 175     


Gly Val Leu Gly His Ala Phe Pro Pro Gly Leu Gly Leu Gly Gly Asp 
            180                 185                 190         


Thr His Phe Asp Glu Asp Glu Asp Trp Thr Lys Asp Gly Ala Gly Phe 
        195                 200                 205             


Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu 
    210                 215                 220                 


Ser His Ser Asn Asp Gln Thr Ala Leu Met Phe Pro Asn Tyr Val Ser 
225                 230                 235                 240 


Leu Asp Pro Asn Lys Tyr Pro Leu Ser Gln Asp Asp Ile Asn Gly Ile 
                245                 250                 255     


Gln Ser Ile Tyr Gly Ser Leu Pro Thr Ala Ser Ala Lys Pro Lys Glu 
            260                 265                 270         


Ser Thr Ile Leu His Ala Cys Asp Pro Asp Leu Thr Phe Asp Ala Ile 
        275                 280                 285             


Thr Thr Phe Arg Arg Glu Val Met Phe Phe Lys Gly Arg His Val Trp 
    290                 295                 300                 


Arg Ile Tyr Tyr Asp Ile Thr Asp Val Glu Phe Glu Leu Ile Ser Ser 
305                 310                 315                 320 


Phe Trp Pro Ser Leu Pro Ala Asp Ile Gln Ala Ala Tyr Glu Asn Pro 
                325                 330                 335     


Lys Asp Lys Met Leu Val Phe Lys Asp Asp Asn Phe Trp Met Ile Arg 
            340                 345                 350         


Gly Tyr Ala Val Leu Pro Asp Phe Pro Lys Pro Ile Arg Thr Leu Gly 
        355                 360                 365             


Phe Pro Arg Ser Val Lys Lys Ile Asp Ala Ala Val Cys Asp His Ser 
    370                 375                 380                 


Thr Arg Lys Thr Tyr Phe Phe Val Gly Ile Trp Cys Trp Arg Tyr Asp 
385                 390                 395                 400 


Glu Val Thr Gln Thr Met Asp Lys Gly Tyr Pro Arg Arg Val Val Lys 
                405                 410                 415     


Tyr Phe Pro Gly Val Gly Leu Arg Val Asp Ala Ala Phe Gln His Lys 
            420                 425                 430         


Gly Phe Phe Tyr Phe Phe Arg Gly Ser Lys Gln Phe Glu Tyr Asp Leu 
        435                 440                 445             


Lys Ala Lys Asn Ile Thr Arg Ile Met Lys Ile Asn Thr Trp Phe Arg 
    450                 455                 460                 


Cys Lys Glu Pro Leu Asn Val Ser Ser Asp Phe Ser Ile Ser Glu Glu 
465                 470                 475                 480 


Val His Ser Gly Gly Val Glu Thr Phe Tyr His Lys Asn Leu Asn Leu 
                485                 490                 495     


Leu Ile Phe Asn Ile Val His Val Leu Lys Lys Ile Tyr Ser Tyr Gln 
            500                 505                 510         


<210>  139
<211>  520
<212>  PRT
<213>  Dog

<400>  139

Met Ala Ala Arg Val Gly Leu Leu Leu Arg Ala Leu Trp Leu Leu Leu 
1               5                   10                  15      


Trp Gly Gly Leu Asp Ala Gln Leu Ala Glu Arg Gly Gly Gln Glu Leu 
            20                  25                  30          


Arg Arg Glu Ala Glu Ala Phe Leu Glu Lys Tyr Gly Tyr Leu Asn Glu 
        35                  40                  45              


Gln Val Pro Lys Asp Leu Thr Ser Ala Arg Phe Ser Asn Ala Ile Arg 
    50                  55                  60                  


Glu Phe Gln Trp Val Ser Gln Leu Pro Ile Ser Gly Val Leu Asp Pro 
65                  70                  75                  80  


Val Thr Leu Arg Gln Met Thr Arg Pro Arg Cys Gly Val Ala Asp Thr 
                85                  90                  95      


Asp Ser Gln Ala Ala Trp Asn Glu Arg Val Ser Ala Leu Phe Ala Gly 
            100                 105                 110         


Gly Arg Ala Lys Met Arg Arg Lys Lys Arg Phe Ala Lys Gln Gly Ser 
        115                 120                 125             


Lys Trp Tyr Lys Gln His Leu Ser Tyr Arg Leu Val Asn Trp Pro Gln 
    130                 135                 140                 


His Leu Pro Glu Pro Ala Val Arg Gly Ala Val Arg Ala Ala Phe Gln 
145                 150                 155                 160 


Leu Trp Ser Asn Val Ser Ala Leu Glu Phe Trp Glu Ala Pro Ala Thr 
                165                 170                 175     


Val Pro Ala Asp Ile Arg Leu Thr Phe Phe Gln Gly Asp His Asn Asp 
            180                 185                 190         


Gly Leu Gly Asn Ala Phe Asp Gly Pro Gly Gly Ala Leu Gly His Ala 
        195                 200                 205             


Phe Leu Pro Arg Arg Gly Glu Ala His Phe Asp Gly Asp Glu Arg Trp 
    210                 215                 220                 


Ser Leu Ser Arg Arg Arg Gly Arg Asn Leu Phe Val Gly Leu Ala His 
225                 230                 235                 240 


Glu Ile Gly His Thr Leu Gly Leu Ala His Ser Pro Ala Pro Arg Ala 
                245                 250                 255     


Leu Met Ala Pro Tyr Tyr Lys Arg Leu Gly Arg Asp Ala Leu Leu Ser 
            260                 265                 270         


Trp Asp Asp Val Leu Ala Val Gln Gly Leu Tyr Gly Lys Pro Gln Gly 
        275                 280                 285             


Gly Ser Val Ala Ile Gln Leu Pro Gly Lys Leu Phe Thr Asp Phe Glu 
    290                 295                 300                 


Ala Trp Asp Pro His Arg Pro Gln Gly Arg Arg Pro Glu Ile Gln Gly 
305                 310                 315                 320 


Pro Lys Tyr Cys His Ser Ser Phe Asp Ala Ile Thr Val Asp Gly Gln 
                325                 330                 335     


Gln Arg Leu Tyr Ile Phe Gln Gly Ser His Phe Trp Glu Val Ala Pro 
            340                 345                 350         


Asp Gly Asn Val Ser Glu Pro Leu Pro Leu Gln Glu Arg Trp Ala Gly 
        355                 360                 365             


Leu Pro Pro His Ile Glu Ala Ala Ala Val Ser Leu Asp Ser Gly Asp 
    370                 375                 380                 


Phe His Phe Phe Lys Gly Ser Arg Cys Trp Arg Phe Arg Gly Pro Lys 
385                 390                 395                 400 


Pro Val Trp Gly Ser Pro Gln Leu Cys Arg Ala Gly Gly Leu Pro Arg 
                405                 410                 415     


His Pro Asp Ala Ala Leu Phe Phe Pro Pro Leu Gly Arg Leu Val Leu 
            420                 425                 430         


Phe Lys Gly Ala Arg Tyr Tyr Val Leu Ala Arg Asp Gly Leu Gln Val 
        435                 440                 445             


Glu Pro Tyr Tyr Pro Arg Gly Leu Gln Asp Trp Gly Gly Val Pro Lys 
    450                 455                 460                 


Glu Val Asn Gly Ala Leu Pro Arg Pro Asp Gly Ser Ile Ile Phe Phe 
465                 470                 475                 480 


Arg Asp Asp Arg Tyr Trp Arg Leu Asp Gln Ala Lys Leu Gln Ala Thr 
                485                 490                 495     


Ala Trp Gly Arg Trp Ala Ala Glu Leu Pro Trp Met Gly Cys Trp His 
            500                 505                 510         


Ala Asn Ser Glu Gly Ala Leu Phe 
        515                 520 


<210>  140
<211>  483
<212>  PRT
<213>  Dog

<400>  140

Met Thr Val Leu Pro Met Cys Gly Leu Ala Leu Leu Leu Gly Ala Ala 
1               5                   10                  15      


Leu Glu Phe Cys Thr Ala Ala Pro Ser Val Ser Ala Ala Ala Pro Arg 
            20                  25                  30          


Thr Thr Gln Asn Lys Tyr His Leu Ala Gln Ala Tyr Leu Asp Lys Tyr 
        35                  40                  45              


Tyr Thr Ser Lys Ala Gly Pro Gln Val Gly Glu Met Gly Ala Pro Gly 
    50                  55                  60                  


Gly Arg Ala Leu Ile Lys Lys Ile Lys Glu Leu Gln Ala Phe Phe Gly 
65                  70                  75                  80  


Leu Arg Ile Thr Gly Lys Leu Asp Arg Pro Thr Met Asp Met Ile Lys 
                85                  90                  95      


Arg Pro Arg Cys Gly Val Pro Asp Val Ala Asn Tyr Arg Leu Phe Pro 
            100                 105                 110         


Gly Glu Pro Lys Trp Lys Lys Asn Thr Leu Thr Tyr Arg Ile Ser Lys 
        115                 120                 125             


Tyr Thr Ser Ser Met Ser Pro Ala Glu Val Asp Lys Ala Val Glu Met 
    130                 135                 140                 


Ala Leu Gln Ala Trp Gly Ser Ala Val Pro Leu Ser Phe Ile Arg Val 
145                 150                 155                 160 


Asn Ser Gly Glu Ala Asp Ile Met Ile Ser Phe Glu Thr Gly Asp His 
                165                 170                 175     


Gly Asp Ser Tyr Pro Phe Asp Gly Pro Arg Gly Thr Leu Ala His Ala 
            180                 185                 190         


Phe Ala Pro Gly Glu Gly Leu Gly Gly Asp Thr His Phe Asp Asn Ala 
        195                 200                 205             


Glu Lys Trp Thr Met Gly Met Asn Gly Phe Asn Leu Phe Thr Val Ala 
    210                 215                 220                 


Ala His Glu Phe Gly His Ala Leu Gly Leu Ala His Ser Thr Asp Pro 
225                 230                 235                 240 


Ser Ala Leu Met Tyr Pro Thr Tyr Lys Tyr Gln His Pro Tyr Gly Phe 
                245                 250                 255     


His Leu Pro Lys Asp Asp Val Lys Gly Ile Gln Ala Leu Tyr Gly Pro 
            260                 265                 270         


Arg Lys Thr Leu Leu Gly Lys Pro Thr Val Pro His Ala Pro Pro Gln 
        275                 280                 285             


Ser Pro Ser Ile Pro Asp Leu Cys Asp Ser Ser Ser Ser Phe Asp Ala 
    290                 295                 300                 


Val Thr Met Leu Gly Lys Glu Leu Leu Leu Phe Arg Asp Arg Ile Phe 
305                 310                 315                 320 


Trp Arg Arg Gln Val His Leu Met Ala Gly Ile Arg Pro Ser Thr Ile 
                325                 330                 335     


Thr Ser Ser Phe Pro Gln Leu Met Ser Asn Val Asp Ala Ala Tyr Glu 
            340                 345                 350         


Val Ala Glu Arg Gly Thr Ala Tyr Phe Phe Lys Gly Pro His Tyr Trp 
        355                 360                 365             


Ile Thr Arg Gly Phe Gln Met Gln Gly Pro Pro Arg Thr Ile Tyr Asp 
    370                 375                 380                 


Phe Gly Phe Pro Arg Tyr Val Gln Arg Ile Asp Ala Ala Val Tyr Leu 
385                 390                 395                 400 


Lys Asp Val Gln Lys Thr Leu Phe Phe Val Gly Asp Glu Tyr Tyr Ser 
                405                 410                 415     


Tyr Asp Glu Arg Lys Arg Lys Met Glu Lys Asp Tyr Pro Lys Asn Thr 
            420                 425                 430         


Glu Glu Glu Phe Ser Gly Val Asn Gly Gln Ile Asp Ala Ala Val Glu 
        435                 440                 445             


Leu Asn Gly Tyr Ile Tyr Phe Phe Ser Gly Pro Lys Ala Tyr Lys Tyr 
    450                 455                 460                 


Asp Thr Glu Lys Glu Asp Val Val Ser Val Leu Lys Ser Ser Ser Trp 
465                 470                 475                 480 


Ile Gly Cys 
            


<210>  141
<211>  394
<212>  PRT
<213>  Dog

<400>  141

Met Gly Leu Gly Ala Cys Val Ser Ser Ala Ala Ser Gly Ala Gln Ala 
1               5                   10                  15      


Gln Ala Arg Trp Leu Gly Ala Val Leu Gly Ala Leu Cys Leu Leu Pro 
            20                  25                  30          


Val Leu Leu Leu Leu Ala Arg Pro Gly Ala Pro Ala Ala Arg Leu Gly 
        35                  40                  45              


Ala Ser Ala Ala Gln Gly Asp Leu Ala Ala Pro Tyr Pro Val Gly Val 
    50                  55                  60                  


Phe Ala Thr Pro Gly Pro Ser Pro Leu Pro Leu Gln Ala Pro Arg Arg 
65                  70                  75                  80  


Arg Arg Tyr Thr Leu Thr Pro Ala Arg Leu Arg Trp Asp His Phe Asn 
                85                  90                  95      


Leu Thr Tyr Arg Ile Leu Ser Phe Pro Arg Asn Leu Leu Ser Pro Ser 
            100                 105                 110         


Glu Thr Arg Arg Gly Leu Ala Thr Ala Phe Arg Met Trp Ser Asp Val 
        115                 120                 125             


Ser Pro Phe Ser Phe Arg Glu Val Ala Pro Glu Gln Pro Ser Asp Leu 
    130                 135                 140                 


Arg Ile Gly Phe Tyr Pro Val Asn His Thr Asp Cys Leu Val Ser Ala 
145                 150                 155                 160 


Leu His His Cys Phe Asp Gly Pro Thr Gly Glu Leu Ala His Ala Phe 
                165                 170                 175     


Phe Pro Pro His Gly Gly Ile His Phe Asp Asp Ser Glu Tyr Trp Val 
            180                 185                 190         


Leu Gly Pro Thr Arg Tyr Ser Trp Lys Lys Gly Val Trp Leu Thr Asp 
        195                 200                 205             


Leu Val His Val Ala Ala His Glu Ile Gly His Ala Leu Gly Leu Met 
    210                 215                 220                 


His Ser Gln His Gly Arg Ala Leu Met His Leu Asn Ala Thr Leu Arg 
225                 230                 235                 240 


Gly Trp Lys Thr Leu Ser Gln Asp Glu Leu Trp Gly Leu His Arg Leu 
                245                 250                 255     


Tyr Gly Cys Leu Asp Arg Leu Phe Val Cys Thr Ser Trp Ala Arg Arg 
            260                 265                 270         


Gly Phe Cys Asp Thr Arg Arg Arg Leu Met Lys Arg Leu Cys Pro Ser 
        275                 280                 285             


Ser Cys Asp Phe Cys Tyr Glu Phe Pro Phe Pro Thr Val Ala Ala Thr 
    290                 295                 300                 


Ala Pro Pro Pro Arg Thr Lys Thr Arg Leu Val Pro Glu Gly Arg Asn 
305                 310                 315                 320 


Val Thr Phe Arg Cys Gly Gln Lys Ile Leu His Lys Lys Gly Lys Val 
                325                 330                 335     


Tyr Trp Tyr Lys Asp Gln Glu Pro Leu Glu Phe Ser Tyr Pro Gly Tyr 
            340                 345                 350         


Leu Ala Leu Gly Glu Ala His Leu Ser Ile Ile Ala Asn Ala Ile Asn 
        355                 360                 365             


Glu Gly Thr Tyr Thr Cys Val Val Arg Arg Arg Gln Arg Val Leu Ser 
    370                 375                 380                 


Thr Tyr Ser Trp Arg Val Arg Val Arg Gly 
385                 390                 


<210>  142
<211>  240
<212>  PRT
<213>  Dog

<400>  142

Ser Ser Gly Thr Leu Glu Ala Ser Val Leu Val Thr Ile Glu Pro Ser 
1               5                   10                  15      


Ser Pro Gly Pro Ile Pro Ala Pro Gly Leu Ala Gln Pro Ile Tyr Ile 
            20                  25                  30          


Glu Ala Ser Ser Ser His Val Ala Glu Gly Gln Ser Leu Asp Leu Asn 
        35                  40                  45              


Cys Val Val Pro Gly Gln Ala His Ala Gln Val Thr Trp Tyr Lys Arg 
    50                  55                  60                  


Gly Gly Ser Leu Pro Ala Arg His Gln Thr His Gly Ser Arg Leu Arg 
65                  70                  75                  80  


Leu His His Val Ser Pro Ala Asp Ser Gly Glu Tyr Val Cys Arg Val 
                85                  90                  95      


Val Gly Gly Ser Gly Pro Glu Gln Glu Ala Ser Phe Thr Val Thr Val 
            100                 105                 110         


Leu Pro Ser Ala Gly Ser Ser Tyr Arg Leu Arg Ser Pro Val Ile Ser 
        115                 120                 125             


Ile Asp Pro Pro Ser Ser Thr Val Gln Gln Gly Gln Asp Ala Ser Phe 
    130                 135                 140                 


Lys Cys Leu Ile His Asp Gly Ala Ala Pro Ile Ser Leu Glu Trp Lys 
145                 150                 155                 160 


Thr Arg Asn Gln Glu Leu Glu Asp Asn Val His Ile Ser Pro Asn Gly 
                165                 170                 175     


Ser Ile Ile Thr Ile Val Gly Thr Arg Pro Ser Asn His Gly Thr Tyr 
            180                 185                 190         


Arg Cys Val Ala Ser Asn Ala Tyr Gly Val Ala Gln Ser Val Val Asn 
        195                 200                 205             


Leu Ser Val His Gly Pro Pro Thr Val Ser Val Leu Pro Glu Gly Pro 
    210                 215                 220                 


Val Arg Val Lys Val Gly Lys Ser Val Thr Leu Glu Cys Val Ser Ala 
225                 230                 235                 240 


<210>  143
<211>  171
<212>  PRT
<213>  Dog

<400>  143

Phe Phe Gln Ile Arg Phe Tyr Met Arg Val Asn Pro Phe Tyr Pro Glu 
1               5                   10                  15      


Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Asn Leu Pro Asn Gly 
            20                  25                  30          


Leu Gln Ala Ala Tyr Glu Val Ser Glu Arg Asp Glu Val Arg Phe Phe 
        35                  40                  45              


Lys Gly Asp Lys Tyr Trp Val Val Gln Gly Gln Asp Val Leu Tyr Gly 
    50                  55                  60                  


Tyr Pro Lys Asp Ile His Arg Ser Phe Gly Phe Pro Arg Thr Val Lys 
65                  70                  75                  80  


Ser Ile Asp Ala Ala Val Ser Asp Glu Asn Thr Gly Lys Thr Tyr Phe 
                85                  90                  95      


Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr Lys Gln Ser Met 
            100                 105                 110         


Asp Ala Gly Tyr Pro Gln Met Ile Ala Ala Gly Phe Pro Gly Ile Gly 
        115                 120                 125             


His Lys Val Asp Ala Val Phe Gln Lys Asp Gly Phe Phe Tyr Phe Phe 
    130                 135                 140                 


His Gly Lys Arg Gln Tyr Lys Phe Asp Leu Arg Thr Lys Arg Val Leu 
145                 150                 155                 160 


Ser Leu Asp Lys Ala Asn Ser Trp Phe Asn Cys 
                165                 170     


<210>  144
<211>  564
<212>  PRT
<213>  Dog

<400>  144

Gln Asn Trp Leu Lys Ser Tyr Gly Tyr Leu Leu Pro Tyr Asp Ser Arg 
1               5                   10                  15      


Ala Ser Ala Leu His Ser Gly Lys Ala Leu Gln Ser Ala Val Ser Thr 
            20                  25                  30          


Met Gln Gln Phe Tyr Gly Ile Pro Val Thr Gly Val Leu Asp Gln Thr 
        35                  40                  45              


Thr Ile Glu Trp Met Lys Lys Pro Arg Cys Gly Val Pro Asp His Pro 
    50                  55                  60                  


His Leu Ser Arg Arg Arg Arg Asn Lys Arg Tyr Ala Leu Thr Gly Gln 
65                  70                  75                  80  


Lys Trp Arg Gln Lys His Ile Thr Tyr Ser Ile His Asn Tyr Thr Pro 
                85                  90                  95      


Lys Val Gly Glu Leu Asp Thr Arg Lys Ala Ile Arg Gln Ala Phe Asp 
            100                 105                 110         


Val Trp Gln Lys Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr His 
        115                 120                 125             


Glu Ile Lys Ser Asp Arg Lys Glu Ala Asp Ile Met Ile Phe Phe Ala 
    130                 135                 140                 


Ser Gly Phe His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe 
145                 150                 155                 160 


Leu Ala His Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His 
                165                 170                 175     


Phe Asp Ser Asp Glu Pro Trp Thr Leu Gly Asn Ala Asn His Asp Gly 
            180                 185                 190         


Asn Asp Leu Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly 
        195                 200                 205             


Leu Glu His Ser Asn Asp Pro Ser Ala Ile Met Ala Pro Phe Tyr Gln 
    210                 215                 220                 


Tyr Met Glu Thr His Asn Phe Lys Leu Pro Gln Asp Asp Leu Gln Gly 
225                 230                 235                 240 


Ile Gln Lys Ile Tyr Gly Pro Pro Ala Glu Pro Leu Glu Pro Thr Arg 
                245                 250                 255     


Pro Leu Pro Thr Leu Pro Val Arg Arg Ile His Ser Pro Ser Glu Arg 
            260                 265                 270         


Lys His Glu Arg Gln Pro Arg Pro Pro Arg Pro Pro Leu Gly Asp Arg 
        275                 280                 285             


Pro Ser Thr Pro Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn 
    290                 295                 300                 


Thr Val Ala Leu Phe Arg Gly Glu Met Phe Val Phe Lys Asp Arg Trp 
305                 310                 315                 320 


Phe Trp Arg Leu Arg Asn Asn Arg Val Gln Glu Gly Tyr Pro Met Gln 
                325                 330                 335     


Ile Glu Gln Phe Trp Lys Gly Leu Pro Ala Arg Ile Asp Ala Ala Tyr 
            340                 345                 350         


Glu Arg Ala Asp Gly Arg Phe Val Phe Phe Lys Gly Asp Lys Tyr Trp 
        355                 360                 365             


Val Phe Lys Glu Val Thr Val Glu Pro Gly Tyr Pro His Ser Leu Gly 
    370                 375                 380                 


Glu Leu Gly Ser Cys Leu Pro Arg Glu Gly Ile Asp Thr Ala Leu Arg 
385                 390                 395                 400 


Trp Glu Pro Val Gly Lys Thr Tyr Phe Phe Lys Gly Glu Arg Tyr Trp 
                405                 410                 415     


Arg Tyr Ser Glu Glu Arg Arg Ala Thr Asp Pro Gly Tyr Pro Lys Pro 
            420                 425                 430         


Ile Thr Val Trp Lys Gly Ile Pro Gln Ala Pro Gln Gly Ala Phe Ile 
        435                 440                 445             


Ser Lys Glu Gly Tyr Tyr Thr Tyr Phe Tyr Lys Gly Arg Asp Tyr Trp 
    450                 455                 460                 


Lys Phe Asp Asn Gln Lys Leu Ser Val Glu Pro Gly Tyr Pro Arg Asn 
465                 470                 475                 480 


Ile Leu Arg Asp Trp Met Gly Cys Asn Gln Lys Glu Val Glu Arg Arg 
                485                 490                 495     


Lys Glu Arg Arg Leu Pro Gln Asp Asp Val Asp Ile Met Val Thr Ile 
            500                 505                 510         


Asn Asp Val Pro Gly Ser Val Asn Ala Val Ala Val Val Ile Pro Cys 
        515                 520                 525             


Ile Leu Ser Leu Cys Ile Leu Val Leu Val Tyr Thr Ile Phe Gln Phe 
    530                 535                 540                 


Lys Asn Lys Ala Gly Pro Gln Pro Val Thr Tyr Tyr Lys Arg Pro Val 
545                 550                 555                 560 


Gln Glu Trp Val 
                


<210>  145
<211>  571
<212>  PRT
<213>  Dog

<400>  145

Lys Glu Leu Tyr Leu Leu Gln Val Trp Leu Gln Lys Tyr Gly Tyr Leu 
1               5                   10                  15      


Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg Ser Ala Glu Thr Met 
            20                  25                  30          


Gln Ala Ala Leu Ala Ala Met Gln Gln Phe Tyr Gly Ile Asn Met Thr 
        35                  40                  45              


Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met Lys Lys Pro Arg Cys 
    50                  55                  60                  


Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys Phe Asn Ile Arg Arg 
65                  70                  75                  80  


Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln His Lys His Ile Thr 
                85                  90                  95      


Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly Asp Pro Glu Thr Arg 
            100                 105                 110         


Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln Asn Val Thr Pro Leu 
        115                 120                 125             


Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu Asn Gly Lys Arg Asp 
    130                 135                 140                 


Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe His Gly Asp Ser Ser 
145                 150                 155                 160 


Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly 
                165                 170                 175     


Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser Asp Glu Pro Trp Thr 
            180                 185                 190         


Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu Phe Leu Val Ala Val 
        195                 200                 205             


His Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Asn Asp Pro Thr 
    210                 215                 220                 


Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu Thr Asp Asn Phe Lys 
225                 230                 235                 240 


Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys Ile Tyr Gly Pro Pro 
                245                 250                 255     


Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro Thr Val Pro Pro His 
            260                 265                 270         


Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn Asp Arg Pro Lys Pro 
        275                 280                 285             


Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro Gly Ala Lys Pro Asn 
    290                 295                 300                 


Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile Leu Arg Arg Glu Met 
305                 310                 315                 320 


Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val Arg Asn Asn Arg Val 
                325                 330                 335     


Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe Trp Arg Gly Leu Pro 
            340                 345                 350         


Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp Gly Asn Phe Val Phe 
        355                 360                 365             


Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp Thr Thr Leu Gln Pro 
    370                 375                 380                 


Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Ser Gly Ile Pro Pro His 
385                 390                 395                 400 


Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val Gly Lys Thr Tyr Phe 
                405                 410                 415     


Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu Glu Met Lys Thr Met 
            420                 425                 430         


Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp Lys Gly Ile Pro Glu 
        435                 440                 445             


Ser Pro Gln Gly Ala Phe Val Glu Lys Lys Asn Lys Gly Phe Thr Tyr 
    450                 455                 460                 


Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn Gln Ile Leu Lys 
465                 470                 475                 480 


Val Glu Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp Phe Met Gly Cys 
                485                 490                 495     


Asp Gly Pro Thr Asp Arg Asp Lys Glu Gly His Ser Pro Pro Asp Asp 
            500                 505                 510         


Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser Thr Val Lys Ala 
        515                 520                 525             


Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys Leu Leu Val Leu 
    530                 535                 540                 


Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr Pro Arg His Ile 
545                 550                 555                 560 


Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val 
                565                 570     


<210>  146
<211>  523
<212>  PRT
<213>  Dog

<400>  146

Cys Arg Arg Leu Ser Leu Ala Pro Pro Ser Leu Leu Pro Cys Pro Pro 
1               5                   10                  15      


Pro Pro Ser Phe Pro Arg Asn Ser Phe Arg Ala Gly Gly His Ser Pro 
            20                  25                  30          


Ala Arg Leu Pro Ala Ala Ala His Lys Ala Gln Pro Ile Ala Asp Leu 
        35                  40                  45              


Pro Ala Ala Gln Arg Gly Ala Leu Thr Pro Gly Arg Ala His Ala Gly 
    50                  55                  60                  


His Arg Trp Gly Leu Pro Gln Pro Ala Gly Thr Pro His Trp Lys Gly 
65                  70                  75                  80  


Arg Ser Leu Ala Gln Ala Val Arg Arg Phe Gln Lys Val Asn Ala Leu 
                85                  90                  95      


Pro Ala Ser Gly Arg Leu Asp Ala Ala Thr Leu Ala Ala Met Asn Arg 
            100                 105                 110         


Pro Arg Cys Gly Val Pro Asp Thr Arg Ala Glu Val Phe Ala Lys Arg 
        115                 120                 125             


Thr Leu Ser Trp Arg Leu Leu Arg Glu Gly Ala Ser Gly Gln Leu Ala 
    130                 135                 140                 


Glu Ala Glu Gln Arg Arg Ile Leu Arg Leu Ala Phe Arg Met Trp Ser 
145                 150                 155                 160 


Glu Val Met Pro Leu His Phe Arg Glu Asp Leu Ala Ala Pro Gly Ala 
                165                 170                 175     


Ala Val Asp Ile Lys Leu Ala Phe Gly Arg Gly Arg His Leu Gly Cys 
            180                 185                 190         


Pro Arg Val Phe Asp Gly Ser Gly Gln Glu Phe Ala His Ala Trp Arg 
        195                 200                 205             


Leu Gly Asp Ile His Phe Asp Asp Asp Glu His Phe Thr Pro Pro Thr 
    210                 215                 220                 


Ser Asp Ser Gly Ile Ser Leu Leu Lys Val Ala Val His Glu Ile Gly 
225                 230                 235                 240 


His Val Leu Gly Leu Pro His Thr Tyr Arg Ala Gly Ser Ile Met Gln 
                245                 250                 255     


Pro Asn Tyr Val Pro Gln Glu Pro Val Phe Glu Leu Asp Trp Ser Asp 
            260                 265                 270         


Arg Lys Ala Ile Gln Lys Leu Tyr Gly Ser Cys Glu Gly Ser Phe Asp 
        275                 280                 285             


Thr Ala Phe Asp Trp Ile Arg Lys Glu Arg Asn Gln His Gly Ala Val 
    290                 295                 300                 


Arg Met Arg Phe Ser Thr Tyr Phe Phe Arg Asn Ser Trp Tyr Trp Leu 
305                 310                 315                 320 


Tyr Glu Asn Arg Asn Asn Arg Thr Arg Tyr Gly Asp Pro Ile Gln Ile 
                325                 330                 335     


Leu Ser Gly Trp His Gly Ile Pro Thr Gln His Ile Asp Ala Phe Val 
            340                 345                 350         


His Leu Trp Thr Trp Arg Arg Asp Glu Arg Tyr Phe Phe Lys Gly Asn 
        355                 360                 365             


Gln Tyr Trp Arg Tyr Asp Ser Asp Lys Asp Gln Ala Tyr Thr Glu Asp 
    370                 375                 380                 


Glu Gln Gly Asn Ile Tyr Pro Lys Leu Ile Ser Glu Gly Phe Pro Gly 
385                 390                 395                 400 


Ile Pro Ser Pro Leu Asp Thr Ala Phe Tyr Asp Arg Arg Lys Gln Leu 
                405                 410                 415     


Ile Tyr Phe Phe Lys Glu Ser Leu Val Phe Ala Phe Asp Val Asn Arg 
            420                 425                 430         


Asn Gln Val Leu Asp Ser Tyr Pro Met Lys Ile Thr Glu Val Phe Pro 
        435                 440                 445             


Gly Ile Glu Pro Gln Asn His Pro Phe Arg Asn Ile Asp Ser Ala Tyr 
    450                 455                 460                 


Tyr Ser Tyr Ala His Asn Ser Leu Phe Phe Phe Lys Gly Ser Ala Tyr 
465                 470                 475                 480 


Trp Lys Val Val Asn Asp Lys Asp Lys Gln Gln His Ser Trp Leu Pro 
                485                 490                 495     


Ser Asn Gly Leu Phe Pro Lys Gln Ser Ile Ser Glu Arg Trp Phe Asp 
            500                 505                 510         


Ile Cys Asp Val His Ala Ser Thr Leu Thr Val 
        515                 520             


<210>  147
<211>  523
<212>  PRT
<213>  Dog

<400>  147

Cys Arg Arg Leu Ser Leu Ala Pro Pro Ser Leu Leu Pro Cys Pro Pro 
1               5                   10                  15      


Pro Pro Ser Phe Pro Arg Asn Ser Phe Arg Ala Gly Gly His Ser Pro 
            20                  25                  30          


Ala Arg Leu Pro Ala Ala Ala His Lys Ala Gln Pro Ile Ala Asp Leu 
        35                  40                  45              


Pro Ala Ala Gln Arg Gly Ala Leu Thr Pro Gly Arg Ala His Ala Gly 
    50                  55                  60                  


His Arg Trp Gly Leu Pro Gln Pro Ala Gly Thr Pro His Trp Lys Gly 
65                  70                  75                  80  


Arg Ser Leu Ala Gln Ala Val Arg Arg Phe Gln Lys Val Asn Ala Leu 
                85                  90                  95      


Pro Ala Ser Gly Arg Leu Asp Ala Ala Thr Leu Ala Ala Met Asn Arg 
            100                 105                 110         


Pro Arg Cys Gly Val Pro Asp Thr Arg Ala Glu Val Phe Ala Lys Arg 
        115                 120                 125             


Thr Leu Ser Trp Arg Leu Leu Arg Glu Gly Ala Ser Gly Gln Leu Ala 
    130                 135                 140                 


Glu Ala Glu Gln Arg Arg Ile Leu Arg Leu Ala Phe Arg Met Trp Ser 
145                 150                 155                 160 


Glu Val Met Pro Leu His Phe Arg Glu Asp Leu Ala Ala Pro Gly Ala 
                165                 170                 175     


Ala Val Asp Ile Lys Leu Ala Phe Gly Arg Gly Arg His Leu Gly Cys 
            180                 185                 190         


Pro Arg Val Phe Asp Gly Ser Gly Gln Glu Phe Ala His Ala Trp Arg 
        195                 200                 205             


Leu Gly Asp Ile His Phe Asp Asp Asp Glu His Phe Thr Pro Pro Thr 
    210                 215                 220                 


Ser Asp Ser Gly Ile Ser Leu Leu Lys Val Ala Val His Glu Ile Gly 
225                 230                 235                 240 


His Val Leu Gly Leu Pro His Thr Tyr Arg Ala Gly Ser Ile Met Gln 
                245                 250                 255     


Pro Asn Tyr Val Pro Gln Glu Pro Val Phe Glu Leu Asp Trp Ser Asp 
            260                 265                 270         


Arg Lys Ala Ile Gln Lys Leu Tyr Gly Ser Cys Glu Gly Ser Phe Asp 
        275                 280                 285             


Thr Ala Phe Asp Trp Ile Arg Lys Glu Arg Asn Gln His Gly Ala Val 
    290                 295                 300                 


Arg Met Arg Phe Ser Thr Tyr Phe Phe Arg Asn Ser Trp Tyr Trp Leu 
305                 310                 315                 320 


Tyr Glu Asn Arg Asn Asn Arg Thr Arg Tyr Gly Asp Pro Ile Gln Ile 
                325                 330                 335     


Leu Ser Gly Trp His Gly Ile Pro Thr Gln His Ile Asp Ala Phe Val 
            340                 345                 350         


His Leu Trp Thr Trp Arg Arg Asp Glu Arg Tyr Phe Phe Lys Gly Asn 
        355                 360                 365             


Gln Tyr Trp Arg Tyr Asp Ser Asp Lys Asp Gln Ala Tyr Thr Glu Asp 
    370                 375                 380                 


Glu Gln Gly Asn Ile Tyr Pro Lys Leu Ile Ser Glu Gly Phe Pro Gly 
385                 390                 395                 400 


Ile Pro Ser Pro Leu Asp Thr Ala Phe Tyr Asp Arg Arg Lys Gln Leu 
                405                 410                 415     


Ile Tyr Phe Phe Lys Glu Ser Leu Val Phe Ala Phe Asp Val Asn Arg 
            420                 425                 430         


Asn Gln Val Leu Asp Ser Tyr Pro Met Lys Ile Thr Glu Val Phe Pro 
        435                 440                 445             


Gly Ile Glu Pro Gln Asn His Pro Phe Arg Asn Ile Asp Ser Ala Tyr 
    450                 455                 460                 


Tyr Ser Tyr Ala His Asn Ser Leu Phe Phe Phe Lys Gly Ser Ala Tyr 
465                 470                 475                 480 


Trp Lys Val Val Asn Asp Lys Asp Lys Gln Gln His Ser Trp Leu Pro 
                485                 490                 495     


Ser Asn Gly Leu Phe Pro Lys Gln Ser Ile Ser Glu Arg Trp Phe Asp 
            500                 505                 510         


Ile Cys Asp Val His Ala Ser Thr Leu Thr Val 
        515                 520             


<210>  148
<211>  635
<212>  PRT
<213>  Dog

<400>  148

Arg Met Pro Arg Glu Leu Gln Glu Ser Pro Ser Gln Ser Pro Pro Ile 
1               5                   10                  15      


Phe Val Phe Ala Gln Asp Tyr Leu Glu Lys Phe Tyr Gln Leu Pro Arg 
            20                  25                  30          


Asn Arg Phe Gln Ser Glu Arg Lys Asn Ser Thr Ser Val Ile Met Glu 
        35                  40                  45              


Lys Leu Arg Glu Met Gln Arg Phe Phe Gly Leu Asn Glu Thr Gly Lys 
    50                  55                  60                  


Pro Asn Gln Glu Thr Leu Glu Met Met Gln Lys Pro Arg Cys Gly Val 
65                  70                  75                  80  


Pro Asp Ser Gly Asp Phe Met Leu Thr Pro Gly Asn Pro Lys Trp Lys 
                85                  90                  95      


Gln Thr Asn Leu Thr Tyr Arg Ile Ile Lys Tyr Thr Pro Gln Leu Ser 
            100                 105                 110         


Glu Ala Asn Val Glu Thr Ala Ile Gln Lys Ala Phe Gln Val Trp Ser 
        115                 120                 125             


Asn Val Ser Pro Leu Thr Phe Thr Lys Val Ser Gln Gly Glu Val Asp 
    130                 135                 140                 


Ile Arg Ile Ser Phe Val Gln Gly Asp His Gly Asp Asn Ser Pro Phe 
145                 150                 155                 160 


Asp Gly Pro Asn Gly Ile Leu Ala His Ala Phe Gln Pro Gly Gln Gly 
                165                 170                 175     


Ile Gly Gly Asp Val His Phe Asp Ala Glu Glu Thr Trp Thr Glu Asn 
            180                 185                 190         


Ser Ser Ser Gln Val Glu Leu His Lys Ala Thr Gly Gln Gln Tyr Thr 
        195                 200                 205             


Thr Glu His Cys Arg Lys Gln Glu Arg Lys Leu Leu Ser Leu Leu Gly 
    210                 215                 220                 


Ile Cys Ser Ser His His Phe Leu Asn Ile Tyr Ile Val Phe Ile Ser 
225                 230                 235                 240 


Pro Lys Ser Leu Tyr Trp Glu Leu Cys Glu Pro Lys Glu Leu Asn Asp 
                245                 250                 255     


Pro Asn Ser His Leu Asp Cys Gln Pro Pro Ile Ser Pro Thr Leu Lys 
            260                 265                 270         


Phe Ser Gln His Ala Ser Lys Ile Cys Ile Trp Lys Val His Leu Arg 
        275                 280                 285             


Leu Cys His Met Leu Pro His Leu Asp Phe Gln Gln Lys Trp Gly Leu 
    290                 295                 300                 


Ser Pro Gln Asn Ala Asn Ser Leu Cys Phe Ser Phe Ser Asn Cys Ser 
305                 310                 315                 320 


Pro His Cys Ala Val Pro Phe Thr Leu Leu Ala Tyr Ile Ser Leu Ser 
                325                 330                 335     


Gln Leu Cys Phe Met Thr Glu Pro Pro Glu Pro Leu Thr Thr Tyr Ser 
            340                 345                 350         


Arg Pro Ser Lys Met Ser Ser Glu Met Tyr Ser Gly Met Gln Lys Met 
        355                 360                 365             


Gln Gly Tyr Tyr Asn Leu Phe Leu Val Ala Ala His Glu Val Gly His 
    370                 375                 380                 


Ser Leu Gly Leu Ser His Ser Thr Asp Pro Gly Ala Leu Met Tyr Pro 
385                 390                 395                 400 


Asn Tyr Val Phe His Asp Pro Ser Thr Tyr Thr Leu Pro Gln Asp Asp 
                405                 410                 415     


Ile Asn Gly Ile Gln Thr Ile Tyr Gly Lys Ser Val Gly Arg Thr Leu 
            420                 425                 430         


Ser Thr Cys Asn Pro Val Gln Pro Thr Gly Pro Ser Thr Pro Thr Thr 
        435                 440                 445             


Cys Asp Pro Arg Leu Thr Phe Asp Ala Ile Ala Thr Leu Arg Gly Glu 
    450                 455                 460                 


Ile Leu Phe Phe Lys Asp Lys Tyr Phe Trp Arg Arg His Pro Gln Leu 
465                 470                 475                 480 


Pro Arg Val Glu Leu Asn Phe Ile Ser Leu Phe Trp Pro Ser Leu Pro 
                485                 490                 495     


Asp Gly Ile Gln Ala Ala Tyr Glu Asp Val Asp Lys Asp Leu Val Phe 
            500                 505                 510         


Leu Phe Lys Gly Ser Gln Tyr Trp Ala Leu Ser Gly Tyr Asp Ile Lys 
        515                 520                 525             


Gln Gly Tyr Pro Lys Asp Ile Ser Asp Tyr Ser Phe Pro Ser Ser Val 
    530                 535                 540                 


Gln Ala Ile Asp Ala Ala Val Tyr Tyr Arg Arg Lys Thr Tyr Phe Phe 
545                 550                 555                 560 


Val Asn Asp Gln Val Trp Ser Arg Tyr Asp Asn Gln Arg Gln Ser Met 
                565                 570                 575     


Glu Pro Gly Tyr Pro Lys Ser Ile Ala Ser Ile Phe Pro Gly Ile Glu 
            580                 585                 590         


Ser Thr Val Asp Ala Val Phe Gln Gln Asn His Val Phe Leu Phe Phe 
        595                 600                 605             


Ser Gly Pro Arg Tyr Tyr Ala Phe Asp Leu Gly Ala His Glu Val Ile 
    610                 615                 620                 


Arg Val Gly Arg Ser Asn Arg Trp Leu Asn Cys 
625                 630                 635 


<210>  149
<211>  470
<212>  PRT
<213>  Dog

<400>  149

Met Lys Phe Leu Leu Leu Val Leu Ile Leu Gln Val Thr Ala Ser Gly 
1               5                   10                  15      


Thr Ile Pro Leu Thr Asn Ser Ala Ser Ser Lys Glu Asn Asp Val Ala 
            20                  25                  30          


Ser Ser Gln Arg Tyr Leu Glu Asn Phe Tyr Gly Phe Val Met Asp Gly 
        35                  40                  45              


Ile Pro Lys Thr Lys Met Gly Val Gly Gly Asn Leu Met Glu Asn Lys 
    50                  55                  60                  


Ile Gln Glu Met Gln Gln Phe Leu Gly Leu Lys Val Thr Gly Lys Leu 
65                  70                  75                  80  


Asp Ala Ser Thr Leu Asp Met Met His Met Pro Arg Cys Gly Leu Pro 
                85                  90                  95      


Asp Val Gln His Phe Ser Thr Met Gln Gly Arg Pro Val Trp Lys Lys 
            100                 105                 110         


His Leu Ile Thr Tyr Arg Ile Asn Asn Tyr Thr Pro Asp Met Gln Pro 
        115                 120                 125             


Ala Asp Val Asp Tyr Ala Ile His Lys Ala Phe Glu Val Trp Ser Asn 
    130                 135                 140                 


Val Thr Pro Leu Lys Phe Arg Lys Val Asn Ser Gly Glu Ala Asp Ile 
145                 150                 155                 160 


Met Ile Leu Phe Ala Ser Arg Ala His Gly Asp Phe Ser Pro Phe Asp 
                165                 170                 175     


Gly Arg Gly Gly Val Ile Ala His Ala Phe Gly Pro Gly Pro Gln Ile 
            180                 185                 190         


Gly Gly Asp Met His Phe Asp Glu Ala Glu Ile Trp Thr Lys Thr Tyr 
        195                 200                 205             


Lys Gly Thr Asn Leu Phe Leu Val Ala Val His Glu Leu Gly His Ser 
    210                 215                 220                 


Leu Gly Leu Gly His Ser Ser Asp Pro Lys Ala Ile Met Phe Pro Thr 
225                 230                 235                 240 


Tyr Ser Tyr Val Asn Pro Asn Thr Phe His Leu Ser Ala Asp Asp Ile 
                245                 250                 255     


His Gly Ile Gln Ser Leu Tyr Gly Gly Pro Glu Lys His Gln Phe Ser 
            260                 265                 270         


Ser Asn Thr Asp Gly Thr Glu Ser Ala Asn Cys Asp Ser Asn Leu Ser 
        275                 280                 285             


Phe Asp Ala Val Thr Thr Val Gly Asn Lys Ile Phe Phe Phe Lys Asp 
    290                 295                 300                 


Arg Phe Leu Trp Trp Arg His Pro Glu Ser Pro Lys Asn Ser Val Thr 
305                 310                 315                 320 


Leu Ile Ser Ser Leu Trp Pro Thr Leu Pro Ser Gly Ile Gln Ala Ala 
                325                 330                 335     


Tyr Glu Ile Gly Ala Arg Asn Gln Val Phe Leu Phe Lys Asp Asp Lys 
            340                 345                 350         


Tyr Trp Leu Ile Ser Asn Leu Arg Pro Gln Pro His Tyr Pro Lys Asn 
        355                 360                 365             


Ile His Ser Leu Gly Phe Pro Asp Ser Val Lys Lys Ile Asp Ala Ala 
    370                 375                 380                 


Val Phe Asn Pro Leu Leu Tyr Lys Thr Tyr Phe Phe Val Asp Asp Gln 
385                 390                 395                 400 


Phe Trp Arg Tyr Asp Glu Lys Thr Gln Phe Met Asp Pro Gly Tyr Pro 
                405                 410                 415     


Lys Leu Ile Thr Lys Tyr Phe Pro Gly Ile Lys Pro Thr Val Asp Ala 
            420                 425                 430         


Val Tyr Tyr Tyr Asn Arg His Tyr Tyr Phe Phe Gln Gly Pro Asp Val 
        435                 440                 445             


Phe Glu Tyr Asp Val Ile Ser His Arg Ile Thr Lys Lys Pro Lys Gln 
    450                 455                 460                 


Ser Ile Met Ser Gly Cys 
465                 470 


<210>  150
<211>  13
<212>  PRT
<213>  Dog


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  150

His Glu Xaa Gly His Xaa Xaa Gly Xaa Xaa His Ser Thr 
1               5                   10              


<210>  151
<211>  7
<212>  PRT
<213>  Dog

<400>  151

Arg Glu His Gly Ala Arg Ser 
1               5           


