                         SEQUENCE LISTING

<110>  Lymperopoulos, Anastasios
       Koch, Walter
 
<120>  Methods and Compositions for Therapeutic Modulation of 
       Aldosterone Levels in Heart Disease

<130>  7752-P11-008

<150>  US 61/389,819
<151>  2010-10-05

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  1357
<212>  DNA
<213>  Rattus norvegicus

<400>  1
cgccgccgcg gacctccctg cggccgccgc ggaccatggg cgacaaaggg acacgagtgt       60

tcaagaaggc aagccccaat ggaaagctca ccgtctacct gggaaagcgg gactttgtgg      120

accacattga cctggtggac cccgtggatg gcgtggtcct ggtggatcct gagtatctca      180

aagaaaggcg agtctacgtg acactgacct gcgccttccg gtatggccgg gaagacctgg      240

atgtcttggg tctgactttt cgcaaagacc tgtttgtggc taacgtgcag tccttcccac      300

cggcccctga ggacaagaag ccactgactc ggctacaaga gcgactcatc aagaagctgg      360

gcgagcatgc ctaccccttc acctttgaga tcccgccaaa ccttccgtgc tcagtcacat      420

tgcaacctgg gcctgaggac acagggaagg cctgcggtgt ggattatgaa gtgaaagcct      480

tctgtgctga gaacctggag gagaagatcc acaaaaggaa ttctgtgcgg ctagtcatcc      540

ggaaggttca atatgcccct gagaggcctg gccctcagcc cacggctgag accaccagac      600

agttcctcat gtcggacaag cccctgcacc ttgaggcatc tctggataag gagatctatt      660

atcatggaga acccatcagc gtcaatgtcc atgtcaccaa caacaccaac aagactgtga      720

agaagatcaa gatctcggtg cgccagtatg cagacatctg tctcttcaac acagctcagt      780

acaagtgccc agtggccatg gaggaagctg atgatactgt ggcacccagc tcaacattct      840

gcaaggtcta cacactgact cccttcctgg caaacaacag agagaagcgg gggcttgccc      900

tcgacgggaa gctcaagcat gaagacacaa atctggcttc cagcactctg ttgcgggaag      960

gcgccaaccg tgaaatcctg ggtatcattg tttcctacaa agtcaaagtg aagctggtgg     1020

tgtcccgggg cggcctgttg ggagaccttg catccagtga tgtggctgtg gaactgccct     1080

ttaccttaat gcaccccaag cctaaagagg agcccccaca tcgggaagtt ccagagagcg     1140

agactccagt agacaccaat ctcatagagc ttgacaccaa tgatgacgac attgtgtttg     1200

aggactttgc tcgtcagcgg ctgaaaggca tgaaggatga caaggacgaa gaggatgatg     1260

gcaccggctc tccacacctc aacaacagat agactggggc cagcctcagc ccagcagctc     1320

caggttcact ctcgcactcg gatgctttct cgtctct                              1357


<210>  2
<211>  418
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Gly Asp Lys Gly Thr Arg Val Phe Lys Lys Ala Ser Pro Asn Gly 
1               5                   10                  15      


Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Ile Asp 
            20                  25                  30          


Leu Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu 
        35                  40                  45              


Lys Glu Arg Arg Val Tyr Val Thr Leu Thr Cys Ala Phe Arg Tyr Gly 
    50                  55                  60                  


Arg Glu Asp Leu Asp Val Leu Gly Leu Thr Phe Arg Lys Asp Leu Phe 
65                  70                  75                  80  


Val Ala Asn Val Gln Ser Phe Pro Pro Ala Pro Glu Asp Lys Lys Pro 
                85                  90                  95      


Leu Thr Arg Leu Gln Glu Arg Leu Ile Lys Lys Leu Gly Glu His Ala 
            100                 105                 110         


Tyr Pro Phe Thr Phe Glu Ile Pro Pro Asn Leu Pro Cys Ser Val Thr 
        115                 120                 125             


Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp Tyr 
    130                 135                 140                 


Glu Val Lys Ala Phe Cys Ala Glu Asn Leu Glu Glu Lys Ile His Lys 
145                 150                 155                 160 


Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Tyr Ala Pro Glu 
                165                 170                 175     


Arg Pro Gln Pro Gln Pro Thr Ala Glu Thr Thr Arg Gln Phe Leu Met 
            180                 185                 190         


Ser Asp Lys Pro Leu His Leu Glu Ala Ser Leu Asp Lys Glu Ile Tyr 
        195                 200                 205             


Tyr His Gly Glu Pro Ile Ser Val Asn Val His Val Thr Asn Asn Thr 
    210                 215                 220                 


Asn Lys Thr Val Lys Lys Ile Lys Ile Ser Val Arg Gln Tyr Ala Asp 
225                 230                 235                 240 


Ile Cys Leu Phe Asn Thr Ala Gln Tyr Lys Cys Pro Val Ala Met Glu 
                245                 250                 255     


Glu Ala Asp Asp Thr Val Ala Pro Ser Ser Thr Phe Cys Lys Val Tyr 
            260                 265                 270         


Thr Leu Thr Pro Phe Leu Ala Asn Asn Arg Glu Lys Arg Gly Leu Ala 
        275                 280                 285             


Leu Asp Gly Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr 
    290                 295                 300                 


Leu Leu Arg Glu Gly Ala Asn Arg Glu Ile Leu Gly Ile Ile Val Ser 
305                 310                 315                 320 


Tyr Lys Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Leu Leu Gly 
                325                 330                 335     


Asp Leu Ala Ser Ser Asp Val Ala Val Glu Leu Pro Phe Thr Leu Met 
            340                 345                 350         


His Pro Lys Pro Lys Glu Glu Pro Pro His Arg Glu Val Pro Glu Ser 
        355                 360                 365             


Glu Thr Pro Val Asp Thr Asn Leu Ile Glu Leu Asp Thr Asn Asp Asp 
    370                 375                 380                 


Asp Ile Val Phe Glu Asp Phe Ala Arg Gln Arg Leu Lys Gly Met Lys 
385                 390                 395                 400 


Asp Asp Lys Asp Glu Glu Asp Asp Gly Thr Gly Ser Pro His Leu Asn 
                405                 410                 415     


Asn Arg 
        


<210>  3
<211>  50
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Glu Thr Pro Val Asp Thr Asn Leu Ile Glu Leu Asp Thr Asn Asp Asp 
1               5                   10                  15      


Asp Ile Val Phe Glu Asp Phe Ala Arg Gln Arg Leu Lys Gly Met Lys 
            20                  25                  30          


Asp Asp Lys Asp Glu Glu Asp Asp Gly Thr Gly Ser Pro His Leu Asn 
        35                  40                  45              


Asn Arg 
    50  


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin II Type-I Receptor agonist peptide

<400>  4

Arg Val Tyr Cys His Pro Leu 
1               5           


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence for PCR

<400>  5
gtccacgagg tgacaaaggt                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence for PCR

<400>  6
catcttttcc aggaggtcca                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence for PCR

<400>  7
caccccttct gcgttgtatt                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence for PCR

<400>  8
ttgaccctaa ccaaggatgc                                                   20


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence for PCR

<400>  9
tgcctgcacc tttgtgatat cg                                                22


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence for PCR

<400>  10
catggcagga caatcgaacc                                                   20


<210>  11
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence for PCR

<400>  11
catcctggac aacctgc                                                      17


<210>  12
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence for PCR

<400>  12
taggtccgaa ccttgcc                                                      17


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence for PCR

<400>  13
tcaagaacga aagtcggagg                                                   20


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence for PCR

<400>  14
ggacatctaa gggcatcac                                                    19


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin II Type-I Receptor agonist peptide

<400>  15

Arg Val Tyr Met His Pro Leu 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin II Type-1 Receptor analog peptide

<400>  16

Asp Arg Val Tyr Met His Pro 
1               5           


