                         SEQUENCE LISTING

<110>  OPKO CURNA LLC
 
<120>  TREATMENT OF SIALIDASE 4 (NEU4) RELATED DISEASES BY INHIBITION OF
        NATURAL ANTISENSE TRANSCRIPT TO NEU4

<130>  NEU4

<150>  US61/390216
<151>  2010-10-06

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  2053
<212>  DNA
<213>  Homo sapiens

<400>  1
gccgctgcgt tggcagccct gtccctgagc ggaacgcagg tcgtctctgg gaggaggagc       60

gagggttgga ctcagtggcc gctgcggtgg cagccctgtc cccaggcgtg gactctgccc      120

tcagcttcac agtcaccgaa gaaatgaagt tacaggaggg gcacaccgtc cttttgtctc      180

tgcctttgag gttggcggga actgaaactg agcatggggg tccctcgtac cccttcacgg      240

acagtgctct tcgagcggga gaggacgggc ctgacctacc gcgtgccctc gctgctcccc      300

gtgccccccg ggcccaccct gctggccttt gtggagcagc ggctcagccc tgacgactcc      360

cacgcccacc gcctggtgct gaggaggggc acgctggccg ggggctccgt gcggtggggt      420

gccctgcacg tgctggggac agcagccctg gcggagcacc ggtccatgaa cccctgccct      480

gtgcacgatg ctggcacggg caccgtcttc ctcttcttca tcgcggtgct gggccacacg      540

cctgaggccg tgcagatcgc cacgggaagg aacgccgcgc gcctctgctg tgtggccagc      600

cgtgacgccg gcctctcgtg gggcagcgcc cgggacctca ccgaggaggc catcggtggt      660

gccgtgcagg actgggccac attcgctgtg ggtcccggcc acggcgtgca gctgccctca      720

ggccgcctgc tggtacccgc ctacacctac cgcgtggacc gccgagagtg ttttggcaag      780

atctgccgga ccagccctca ctccttcgcc ttctacagcg atgaccacgg ccgcacctgg      840

cgctgtggag gcctcgtgcc caacctgcgc tcaggcgagt gccagctggc ggcggtggac      900

ggtgggcagg ccggcagctt cctctactgc aatgcccgga gcccactggg cagccgtgtg      960

caggcgctca gcactgacga gggcacctcc ttcctgcccg cagagcgcgt ggcttccctg     1020

cccgagactg cctggggctg ccagggcagc atcgtgggct tcccagcccc cgcccccaac     1080

aggccacggg atgacagttg gtcagtgggc cccgggagtc ccctccagcc tccactcctc     1140

ggtcctggag tccacgaacc cccagaggag gctgctgtag acccccgtgg aggccaggtg     1200

cctggtgggc ccttcagccg tctgcagcct cggggggatg gccccaggca gcctggcccc     1260

aggcctgggg tcagtgggga tgtggggtcc tggaccctgg cactccccat gccctttgct     1320

gccccgcccc agagccccac gtggctgctg tactcccacc cagtggggcg cagggctcgg     1380

ctacacatgg gtatccgcct gagccagtcc ccgctggacc cgcgcagctg gacagagccc     1440

tgggtgatct acgagggccc cagcggctac tccgacctgg cgtccatcgg gccggctcct     1500

gaggggggcc tggtttttgc ctgcctgtac gagagcgggg ccaggacctc ctatgatgag     1560

atttcctttt gtacattctc cctgcgtgag gtcctggaga acgtgcccgc cagccccaag     1620

ccgcccaacc ttggggacaa gcctcggggg tgctgctggc cctcctgaca ggccttctgg     1680

ccgtgcccat gccccttggg tgcctggggc agaggggtgg aatacgttgg ggtgccccac     1740

gatagctgtg gggggggctc ttagtgcaag atcctgtgga ttagaaacaa gttgctcctc     1800

agagctctca agcagggact gctctttagg aaggggagca gcggctggga gtgagcaggg     1860

cagggtgggg gcagggtggg ggcacgaagt gggccctggg tgacccccac agctcccttc     1920

cgaggctgca gggccaggcg cgggaccgca ggtagcccag ggtgttgtgg gtggcagcac     1980

ttgtttactg gctgctttct ggctcgaaat aaaggaatcg tgcttgtgtc gggaaaaaaa     2040

aaaaaaaaaa aaa                                                        2053


<210>  2
<211>  2119
<212>  DNA
<213>  Homo sapiens

<400>  2
aacatcttgg cgaggggcat tcacatgcac ccacataaag tgcagaggcc ctttgcacag       60

aatcccggca gggggccctc ggcggctctg accctcagcc tgcaccgtga gcgtcctggg      120

ccctggccag ggcgaagact ccgaccacag acccttcacc tggtagaggg tccccgacca      180

gcccatctgc agaacgaccc tgtgggctgg ggccggcccc ctgcattggg cccctcacaa      240

ccagtctgtc tccatcccat gccctgaatc tgcccccagg aaccctcagt gtcacaccca      300

ccctgtgggc caggtcaagg cactcaacac tggggtgctg aggacacggg ggtgcgccct      360

ccaacaaggg ctgtgctggg acaggcccag ctgtgaggcc gcagttgacc tcccagaggg      420

acacgggtct gctgctccag agacgcggcc ctgccaggag ggctccgtga gtgcacactc      480

tcctctgggc ttcccgggtg cggggcctcc cctggcacag cacagcccct cacagcacag      540

gcctcgctgg gctctagctc tgtatctgtg ctcctggcag gccagcaccc catcgcaatg      600

tcctgtgcct ctcagggccc agggtgaccc ctccccagca cagctgccct gcaggactcc      660

tgccagtccc attcacgctg gcctgccccc agcctgtccc cgcaggactc ctgccagtcc      720

cattcacgct ggcctgcccc cagcctgtcc ccgcaggact cctgccagtc cctttcacgc      780

tggcctgccc ccagcctgtc cccgcaggac tcctgccagt ccctttcacg ctggcctgcc      840

cccagcctgc catttcagag gcagccttgg taaccaatgc tcaaatgacc actgcccagg      900

ccagaatctc agaggaggcc acaggtcccc ggtatgttct gatggggcag cctccgtggg      960

ggatccctgg gccctgaaca ccctcctttc tcactgtccc tccctcccct gcgaagggca     1020

tcctcagctg cttctgaaac ctggggcgct gtggtgggaa acaggtaggt cacgtggttt     1080

ccaggctttt caagcccact gttttcaatc tagagatttc acagaaaaac ccgtgttttc     1140

agcttctctt gaaaagtcag atctgccctc aggtgccacc cacttcccca gggacaaaag     1200

gacggtgtgc ccctcctgta acttcatttc ttcggtgact gtgaagctga gggcagagtc     1260

cacgcctggg gacagggctg ccaccgcagc ggccactgcg tccaaccctc gctcctcctc     1320

ccagagacga cctgcgttcc gctcagggac agggctgcca acgcagcggc caccgcaccc     1380

aacgctcgct cctcctccca gagacaacct gagctctgct cagaagcggc acctcctcat     1440

gctggactca ctcgggccca catgtgccaa gggggcctgg ttttggggcc ggcgggttct     1500

gcctgatgct cagagggtaa ctggatgctg aaaactgtga gtctttcttc aactcagggg     1560

aatgtttcca gggcacgcca ggcctcactc acgcaggcct ccgcgacaac tgttcagcac     1620

tgactgaggg tgaagtgaaa tcctgaaagc tgagagccag cgccctcaca cgagggctgg     1680

gacgtaacaa aagcccatca agagttttgc ccagggcttt cttgggcctt gaagcatgac     1740

gagaccagga cccgtttagg attaaacaag ttttactggg ggtctgaaaa aactccccag     1800

gcctccacaa acaagtggag aaggaactcc ccaaacctcc atgatttagc agaagacaag     1860

ataagggtaa acacctgggc ccatttagat caagtaaatt tactgagtct tcagaggaag     1920

atcttcagga ccagacctca gttagagatg agaagaattg aatcacgtac gtctttagac     1980

gaatgcacac tgacacggag acacagagct tagaaggtgt gtaagctctg gaaaaactgt     2040

aatctggagt tggtctggcg atcatttcca ggccttctcc ctgtaaccag ttacagaaat     2100

aaaatccctc ttcttcccc                                                  2119


<210>  3
<211>  1245
<212>  DNA
<213>  Homo sapiens

<400>  3
cccacgcgtc cggaatctca gaggaggcca caggtccccg gtaagttctg atggggcagc       60

ctccgtgggg gatccctggg ccctgaacac cctcctttct cactgtccct ccctcccctg      120

cgaagggcat cctcagctgc ttctgaaacc tggggcgctg tggtgggaaa cagcccagac      180

aggctgttct caacactctc tactgcaaac tacacacagt tttacgtcgc cagaaagacc      240

ccaaatttct attcaaaaag accgtaccag tttcagttcc cgccaacctc aaaggcagag      300

acaaaaggac ggtgtgcccc tcctgtaact tcatttcttc ggtgactgtg aagctgaggg      360

cagagtccac gcctggggac agggctgcca ccgcagcggc cactgagtcc aaccctcgct      420

cctcctccca gagacgacct gcgttccgct cagggacagg gctgccaacg cagcggccac      480

cgcacccaac gctcgctcct cctcccagag acaacctgag ctctgctcag aagcggcacc      540

tcctcatgct ggactcactc gggcccacat gtgccaaggg ggcctggttt tggggccggc      600

gggttctgcc tgatgctcag agggtaactg gatgctgaaa actgtgagtc tttcttcaac      660

tcaggggaat gtttccaggg cacgccaggc ctcactcacg caggcctccg cgacaactgt      720

tcagcactga ctgagggtga agtgaaatcc tgaaagctga gagccagcgc cctcacacga      780

gggctgggac gtaacaaaag cccatcaaga gttttgccca gggctttctt gggccttgaa      840

gcatgacgag accaggaccc gtttaggatt aagcaagttt tactgggggt ctgaaaaaac      900

tccccaggcc tccacaaaca agtggagaag gaactcccca aacctccatg atttagcaga      960

aaacaagata agggtaaaca cctgggccca tttagatcaa gtaaatttac tgagtcttca     1020

gaggaagatc ttcaggacca aacctcagtt agagatgaga agaattgaat cacgtacgtc     1080

tttagacgaa tgcacactga cacggagaca cagagcttag aaggtgtgta agctctggaa     1140

aaactgtaat ctggagttgg tctggcgatc atttccaggc cttctccctg taaccagtta     1200

cagaaataaa atccctcttc ttccccagtt aaaaaaaaaa aaaaa                     1245


<210>  4
<211>  490
<212>  DNA
<213>  Homo sapiens

<400>  4
ccacgcgtcc gctcagagga ggccacaggt ccccgcccag acaggctgtt ctcaacactc       60

tctactgcaa actacacaca gttttacgtc gccagaaaga ccccaaattt ctattcaaaa      120

agaccgtacc agtttcagtt cccgccaacc tcaaaggcag agacaaaagg acggtgtgcc      180

cctcctgtaa cttcatttct tcggtgactg tgaagctgag ggcagagtcc acgcctgggg      240

acagggctgc caccgcagcg gccactgagt ccaaccctcg ctcctcctcc cagagacgac      300

ctgcgttccg ctcagggaca gggctgccaa cgcagcggcc accgcaccca acgctcgctc      360

ctcctcccag agacaacctg agctctgctc agaagcggca cctcctcatg ctggactcac      420

tcgggcccac atgtgccaag ggggcctggt tttggggccg gcgggttctg cctgatgctc      480

agagggtaac                                                             490


<210>  5
<211>  527
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (495)..(495)
<223>  n is a, c, g, or t

<400>  5
cccacgcgtc gcccacgcgt ccggaatctc agaggaggcc acaggtcccc ggtaagttct       60

gatggggcag cctccgtggg ggatccctgg gccctgaaca ccctcctttc tcactgtccc      120

tccctcccct gcgaagggca tcctcagctg cttctgaaac ctggggcgct gtggtgggaa      180

acagcccaga caggctgttc tcaacactct ctactgcaaa ctacacacag ttttacgtcg      240

ccagaaagac cccaaatttc tattcaaaaa gaccgtacca gtttcagttc ccgccaacct      300

caaaggcaga gacaaaagga cggtgtgccc ctccctgtaa cttcatttct tcggtgactg      360

tgaagctgag ggcagagtcc acgcctgggg acagggctgc caccgcagcg gccactgagt      420

ccaaccctcg ctcctcctcc cagagacgac ctgcgttccg ctcagggaca gggctgccaa      480

cgcagcggcc accgnaccca acgctcgctc ctcctcccag agacaac                    527


<210>  6
<211>  946
<212>  DNA
<213>  Homo sapiens

<400>  6
ctcagaggag gccacaggtc cccgcccaga caggctgttc tcaacactct ctactgcaaa       60

ctacacacag ttttacgtcg ccagaaagac cccaaatttc tattcaaaaa gaccgtacca      120

gtttcagttc ccgccaacct caaaggcaga gacaaaagga cggtgtgccc ctcctgtaac      180

ttcatttctt cggtgactgt gaagctgagg gcagagtcca cgcctgggga cagggctgcc      240

accgcagcgg ccactgagtc caaccctcgc tcctcctccc agagacgacc tgcgttccgc      300

tcagggacag ggctgccaac gcagcggcca ccgcacccaa cgctcgctcc tcctcccaga      360

gacaacctga gctctgctca gaagcggcac ctcctcatgc tggactcact cgggcccaca      420

tgtgccaagg gggcctggtt ttggggccgg cgggttctgc ctgatgctca gagggtaact      480

ggatgctgaa aactgtgagt ctttcttcaa ctcaggggaa tgtttccagg gcacgccagg      540

cctcactcac gcaggcctcc gcgacaactg ttcagcactg actgagggtg aagtgaaatc      600

ctgaaagctg agagccagcg ccctcacacg agggctttga ccgtaacaaa agccatcaag      660

agtatgccca gggctttctt gggccttgag catgacgaga ccaggaccgg ttaggatcac      720

ggcagttact gcgggtctga aaaactccca ggctcacaac agtgggcaca ggaatcccaa      780

gatcctccag gatttgccgc aaacacacgc atcagtggac acaccggggg cccattgact      840

caggacactc cgagacctga gatgaaaact ctgggcacaa acccgtatga agcagacaaa      900

gtacacgcgc gctaagacag gacgctgaca ggaacacaca gggtgc                     946


<210>  7
<211>  703
<212>  DNA
<213>  Homo sapiens

<400>  7
ctcagacgag gccacaggtc cccggtcatc ctcacctgct tctgaaacct ggggcgctgt       60

ggtgggaaac agcccagaca ggctgtcctc aacactctct actgcaaact acacacagtt      120

ttacgtcgcc agaaagaccc caaatttcta ttcacataaa gaccgatacc acgatttcaa      180

gttccacgcc gaaccgtcaa taggcagagg acaaagagga cgagtgtgcc ccatcctgta      240

actttcactt tccttcaggt gacctgatga acggccatga cggcgcacga cggtccaacc      300

gccatggggg aacagggtca tgccagccga catgccgagc cagctgagct ccaaatccct      360

cgacatccgt cactcgcgca gaaagaacga accgttgccg ctatccggcc atcaagggtc      420

acacgcggcc ctgtccagaa cgcacacgcc gcgggccagc ccggcaaccc caagagaccg      480

ccttcggtca ttctcgtccc gttcctccat gaaagaagca gagcccgttg gaatggcctt      540

ccctggccat tcaaggcaac aaggcgcgtg gtccacccct ttcgcttcca attgcccttg      600

gcgacacctt tacaaaccgt tccggagctg gcccccaagc cacttggttg cccccaaacg      660

cgcgggagcc ccttggcgct tttaaagggc acacgcgcac ccg                        703


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  8
gggtctgtgg tcggagtctt                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  9
ggcagattca gggcatggga                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  10
gacctacctg tttcccacca c                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  11
tgtcccagca cagcccttgt                                                   20


