                         SEQUENCE LISTING

<110>  Academisch Ziekenhuis bij de Universiteit van Amsterdam
       Arthrogen B.V.
 
<120>  Treatment of the Sjgren's syndrome

<130>  P6032717PCT

<160>  30    

<170>  PatentIn version 3.3

<210>  1
<211>  285
<212>  PRT
<213>  homo sapiens

<400>  1

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210>  2
<211>  1052
<212>  DNA
<213>  homo sapiens

<400>  2
tgccaagccc tgccatgtag tgcacgcagg acatcaacaa acacagataa caggaaatga     60

tccattccct gtggtcactt attctaaagg ccccaacctt caaagttcaa gtagtgatat    120

ggatgactcc acagaaaggg agcagtcacg ccttacttct tgccttaaga aaagagaaga    180

aatgaaactg aaggagtgtg tttccatcct cccacggaag gaaagcccct ctgtccgatc    240

ctccaaagac ggaaagctgc tggctgcaac cttgctgctg gcactgctgt cttgctgcct    300

cacggtggtg tctttctacc aggtggccgc cctgcaaggg gacctggcca gcctccgggc    360

agagctgcag ggccaccacg cggagaagct gccagcagga gcaggagccc ccaaggccgg    420

cctggaggaa gctccagctg tcaccgcggg actgaaaatc tttgaaccac cagctccagg    480

agaaggcaac tccagtcaga acagcagaaa taagcgtgcc gttcagggtc cagaagaaac    540

agtcactcaa gactgcttgc aactgattgc agacagtgaa acaccaacta tacaaaaagg    600

atcttacaca tttgttccat ggcttctcag ctttaaaagg ggaagtgccc tagaagaaaa    660

agagaataaa atattggtca aagaaactgg ttactttttt atatatggtc aggttttata    720

tactgataag acctacgcca tgggacatct aattcagagg aagaaggtcc atgtctttgg    780

ggatgaattg agtctggtga ctttgtttcg atgtattcaa aatatgcctg aaacactacc    840

caataattcc tgctattcag ctggcattgc aaaactggaa gaaggagatg aactccaact    900

tgcaatacca agagaaaatg cacaaatatc actggatgga gatgtcacat tttttggtgc    960

attgaaactg ctgtgaccta cttacaccat gtctgtagct attttcctcc ctttctctgt   1020

acctctaaga agaaagaatc taactgaaaa ta                                 1052


<210>  3
<211>  309
<212>  PRT
<213>  mus musculus

<400>  3

Met Asp Glu Ser Ala Lys Thr Leu Pro Pro Pro Cys Leu Cys Phe Cys 
1               5                   10                  15      


Ser Glu Lys Gly Glu Asp Met Lys Val Gly Tyr Asp Pro Ile Thr Pro 
            20                  25                  30          


Gln Lys Glu Glu Gly Ala Trp Phe Gly Ile Cys Arg Asp Gly Arg Leu 
        35                  40                  45              


Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Ser Ser Phe Thr Ala 
    50                  55                  60                  


Met Ser Leu Tyr Gln Leu Ala Ala Leu Gln Ala Asp Leu Met Asn Leu 
65                  70                  75                  80  


Arg Met Glu Leu Gln Ser Tyr Arg Gly Ser Ala Thr Pro Ala Ala Ala 
                85                  90                  95      


Gly Ala Pro Glu Leu Thr Ala Gly Val Lys Leu Leu Thr Pro Ala Ala 
            100                 105                 110         


Pro Arg Pro His Asn Ser Ser Arg Gly His Arg Asn Arg Arg Ala Phe 
        115                 120                 125             


Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala Pro Pro 
    130                 135                 140                 


Ala Pro Cys Leu Pro Gly Cys Arg His Ser Gln His Asp Asp Asn Gly 
145                 150                 155                 160 


Met Asn Leu Arg Asn Ile Ile Gln Asp Cys Leu Gln Leu Ile Ala Asp 
                165                 170                 175     


Ser Asp Thr Pro Thr Ile Arg Lys Gly Thr Tyr Thr Phe Val Pro Trp 
            180                 185                 190         


Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys 
        195                 200                 205             


Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu 
    210                 215                 220                 


Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys 
225                 230                 235                 240 


Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys 
                245                 250                 255     


Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala 
            260                 265                 270         


Gly Ile Ala Arg Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro 
        275                 280                 285             


Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly 
    290                 295                 300                 


Ala Leu Lys Leu Leu 
305                 


<210>  4
<211>  1710
<212>  DNA
<213>  mus musculus

<400>  4
ggcacgaggc agattgagca atccatggaa ggccagagcc agagaaccta cttcagggta     60

gcaaaagatg cagaagaaag tcaggagagc gctcctgggg gaacccagcc ctgccatgct    120

ctgagggcag tctcccagga cacagatgac aggaaatgac ccacccctgt ggtcacttac    180

tccaaaggcc tagaccttca aagtgctcct cgtggaatgg atgagtctgc aaagaccctg    240

ccaccaccgt gcctctgttt ttgctccgag aaaggagaag atatgaaagt gggatatgat    300

cccatcactc cgcagaagga ggagggtgcc tggtttggga tctgcaggga tggaaggctg    360

ctggctgcta ccctcctgct ggccctgttg tccagcagtt tcacagcgat gtccttgtac    420

cagttggctg ccttgcaagc agacctgatg aacctgcgca tggagctgca gagctaccga    480

ggttcagcaa caccagccgc cgcgggtgct ccagagttga ccgctggagt caaactcctg    540

acaccggcag ctcctcgacc ccacaactcc agccgcggcc acaggaacag acgcgctttc    600

cagggaccag aggaaacaga acaagatgta gacctctcag ctcctcctgc accatgcctg    660

cctggatgcc gccattctca acatgatgat aatggaatga acctcagaaa catcattcaa    720

gactgtctgc agctgattgc agacagcgac acgccgacta tacgaaaagg aacttacaca    780

tttgttccat ggcttctcag ctttaaaaga ggaaatgcct tggaggagaa agagaacaaa    840

atagtggtga ggcaaacagg ctatttcttc atctacagcc aggttctata cacggacccc    900

atctttgcta tgggtcatgt catccagagg aagaaagtac acgtctttgg ggacgagctg    960

agcctggtga ccctgttccg atgtattcag aatatgccca aaacactgcc caacaattcc   1020

tgctactcgg ctggcatcgc gaggctggaa gaaggagatg agattcagct tgcaattcct   1080

cgggagaatg cacagatttc acgcaacgga gacgacacct tctttggtgc cctaaaactg   1140

ctgtaactca cttgctggag tgcgtgatcc ccttccctcg tcttctctgt acctccgagg   1200

gagaaacaga cgactggaaa aactaaaaga tggggaaagc cgtcagcgaa agttttctcg   1260

tgacccgttg aatctgatcc aaaccaggaa atataacaga cagccacaac cgaagtgtgc   1320

catgtgagtt atgagaaacg gagcccgcgc tcagaaagac cggatgagga agaccgtttt   1380

ctccagtcct ttgccaacac gcaccgcaac cttgcttttt gccttgggtg acacatgttc   1440

agaatgcagg gagatttcct tgttttgcga tttgccatga gaagagggcc cacaactgca   1500

ggtcactgaa gcattcacgc taagtctcag gatttactct cccttctcat gctaagtaca   1560

cacacgctct tttccaggta atactatggg atactatgga aaggttgttt gtttttaaat   1620

ctagaagtct tgaactggca atagacaaaa atccttataa attcaagtgt aaaataaact   1680

taattaaaaa ggtttaagtg tgaaaaaaaa                                    1710


<210>  5
<211>  266
<212>  PRT
<213>  homo sapiens

<400>  5

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Gly Ser Tyr 
    130                 135                 140                 


Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu 
145                 150                 155                 160 


Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile 
                165                 170                 175     


Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu 
            180                 185                 190         


Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val 
        195                 200                 205             


Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn 
    210                 215                 220                 


Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu 
225                 230                 235                 240 


Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp 
                245                 250                 255     


Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
            260                 265     


<210>  6
<211>  801
<212>  DNA
<213>  homo sapiens

<400>  6
atggatgact ccacagaaag ggagcagtca cgccttactt cttgccttaa gaaaagagaa     60

gaaatgaaac tgaaggagtg tgtttccatc ctcccacgga aggaaagccc ctctgtccga    120

tcctccaaag acggaaagct gctggctgca accttgctgc tggcactgct gtcttgctgc    180

ctcacggtgg tgtctttcta ccaggtggcc gccctgcaag gggacctggc cagcctccgg    240

gcagagctgc agggccacca cgcggagaag ctgccagcag gagcaggagc ccccaaggcc    300

ggcctggagg aagctccagc tgtcaccgcg ggactgaaaa tctttgaacc accagctcca    360

ggagaaggca actccagtca gaacagcaga aataagcgtg ccgttcaggg tccagaagaa    420

acaggatctt acacatttgt tccatggctt ctcagcttta aaaggggaag tgccctagaa    480

gaaaaagaga ataaaatatt ggtcaaagaa actggttact tttttatata tggtcaggtt    540

ttatatactg ataagaccta cgccatggga catctaattc agaggaagaa ggtccatgtc    600

tttggggatg aattgagtct ggtgactttg tttcgatgta ttcaaaatat gcctgaaaca    660

ctacccaata attcctgcta ttcagctggc attgcaaaac tggaagaagg agatgaactc    720

caacttgcaa taccaagaga aaatgcacaa atatcactgg atggagatgt cacatttttt    780

ggtgcattga aactgctgtg a                                              801


<210>  7
<211>  290
<212>  PRT
<213>  mus musculus

<400>  7

Met Asp Glu Ser Ala Lys Thr Leu Pro Pro Pro Cys Leu Cys Phe Cys 
1               5                   10                  15      


Ser Glu Lys Gly Glu Asp Met Lys Val Gly Tyr Asp Pro Ile Thr Pro 
            20                  25                  30          


Gln Lys Glu Glu Gly Ala Trp Phe Gly Ile Cys Arg Asp Gly Arg Leu 
        35                  40                  45              


Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Ser Ser Phe Thr Ala 
    50                  55                  60                  


Met Ser Leu Tyr Gln Leu Ala Ala Leu Gln Ala Asp Leu Met Asn Leu 
65                  70                  75                  80  


Arg Met Glu Leu Gln Ser Tyr Arg Gly Ser Ala Thr Pro Ala Ala Ala 
                85                  90                  95      


Gly Ala Pro Glu Leu Thr Ala Gly Val Lys Leu Leu Thr Pro Ala Ala 
            100                 105                 110         


Pro Arg Pro His Asn Ser Ser Arg Gly His Arg Asn Arg Arg Ala Phe 
        115                 120                 125             


Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala Pro Pro 
    130                 135                 140                 


Ala Pro Cys Leu Pro Gly Cys Arg His Ser Gln His Asp Asp Asn Gly 
145                 150                 155                 160 


Met Asn Leu Arg Asn Arg Thr Tyr Thr Phe Val Pro Trp Leu Leu Ser 
                165                 170                 175     


Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys Ile Val Val 
            180                 185                 190         


Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu Tyr Thr Asp 
        195                 200                 205             


Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys Val His Val 
    210                 215                 220                 


Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn 
225                 230                 235                 240 


Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala 
                245                 250                 255     


Arg Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro Arg Glu Asn 
            260                 265                 270         


Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly Ala Leu Lys 
        275                 280                 285             


Leu Leu 
    290 


<210>  8
<211>  873
<212>  DNA
<213>  mus musculus

<400>  8
atggatgagt ctgcaaagac cctgccacca ccgtgcctct gtttttgctc cgagaaagga     60

gaagatatga aagtgggata tgatcccatc actccgcaga aggaggaggg tgcctggttt    120

gggatctgca gggatggaag gctgctggct gctaccctcc tgctggccct gttgtccagc    180

agtttcacag cgatgtcctt gtaccagttg gctgccttgc aagcagacct gatgaacctg    240

cgcatggagc tgcagagcta ccgaggttca gcaacaccag ccgccgcggg tgctccagag    300

ttgaccgctg gagtcaaact cctgacaccg gcagctcctc gaccccacaa ctccagccgc    360

ggccacagga acagacgcgc tttccaggga ccagaggaaa cagaacaaga tgtagacctc    420

tcagctcctc ctgcaccatg cctgcctgga tgccgccatt ctcaacatga tgataatgga    480

atgaacctca gaaacagaac ttacacattt gttccatggc ttctcagctt taaaagagga    540

aatgccttgg aggagaaaga gaacaaaata gtggtgaggc aaacaggcta tttcttcatc    600

tacagccagg ttctatacac ggaccccatc tttgctatgg gtcatgtcat ccagaggaag    660

aaagtacacg tctttgggga cgagctgagc ctggtgaccc tgttccgatg tattcagaat    720

atgcccaaaa cactgcccaa caattcctgc tactcggctg gcatcgcgag gctggaagaa    780

ggagatgaga ttcagcttgc aattcctcgg gagaatgcac agatttcacg caacggagac    840

gacaccttct ttggtgccct aaaactgctg taa                                 873


<210>  9
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  DNA coding for murine antisense BAFF

<400>  9
tatagtcggc gtgtcgctgt ctgcaatcag ctgcagacag                           40


<210>  10
<211>  3034
<212>  DNA
<213>  mus musculus

<400>  10
ggatccccta cccagctggg accctcccca acccccttct tcctcaccct ctgcacgaga     60

acgaagttct tcgtcaccag ctttttggta aggatggagg aggggaggcg tacgtgaggg    120

aagaccagaa cagaggaact cgggggggta gaagggccaa atggagtttg gagagagatg    180

tgagcagcta agatagaaac ggagacctga ggcccttcta aaggagcctc aagagctagg    240

gctcgttccc ttctaaagga gcctcaagag ctagggctcg ttccgttcca ccacaggccg    300

acagatagag cataggctag gtgctgtaac tttgcatttt agcctcagct tcctctgtct    360

gtctggaacg ttggctgact gtccccatcc agcagtcatt tactcctgtg ccttcttctc    420

acagctgccc cttaccggga cctgccggcc tccctttctg ctccaatgtc agcggctcat    480

cagctgcagg ccatgcacgc gcagtcagct gagctgcagc gcttggcgct ggaacagcag    540

cagtggctac atgctcatca cccattgcac agcgtgccac tacctgccca ggaagactac    600

tacaggtact ccaggttgcc cccagagcac aaggggaagt gggttctggg catggtccaa    660

caggacaccg agcccttggg aggggaagcc ccctttctca gtctcatctc tgcattgcct    720

cttatctagt cacctgaaga aggagagtga caagccgctg tagagctgcg atccagacag    780

cacccactgc tccttcatcc agaccttgga ggaccacccc aaccttttga ccccacccca    840

cccccagccg aggagagggt gctgcccgct tgcagagctc ctgcagctgg gtagagggag    900

ggagggaaga agggacagac aaggtcaggg cccggggttg tgtgcagagg tgggaagtgg    960

caagggtggg ggcagaaagt gcacagtatc ttggaccagg tccctcctcc tatcccctgc   1020

ttttcttctc ctctatgccg aatccttggt ggccactgcc cctcccctaa cccattggtg   1080

tgattttttt catctgttag atgtggctgt tttgcgtagc attgtgtgct gccccgcccc   1140

atccctgtgt gtgcaccccc tccctcggcg atatgtgccc ttacccgtcc cacattaata   1200

atttatatat ataaatatct atatgatgct ctttaaaaaa catcctgacc aaaaccaacc   1260

aaacaaaaac atcctcacag ttccccagga atatgtctgt gacgtgtttt ttatttgggg   1320

gagggtggtt gcagtgggta gggtgttggg gtgggtaggg agagaggtct ggttgttgta   1380

ggggaagtgg gaagggatga atggggtttt cttatggaaa cttaggagtt ggacaaggct   1440

cttttttatt actcatttat tttacaagag tcttcatgca taccagaaga gaatatcaaa   1500

tcccattaca gatggttgtg agccaccaag tggttgctgg gaattgaact caggacacct   1560

ggaagagcag tctgtgctct taaccccctg agccatctct ttaacctgac aaggctcttc   1620

ttgatcttgg atgctcagct atacttatgg ggtgccctgt cctagacctt tagattgggg   1680

agttcaggct cctgaggccg ttcagagcaa gaataggcgc acagcaagca taagcaaatc   1740

taagacctac tcagcccttg gaagtacatc actgacataa tgtgccacca gagtgctcca   1800

gagacagttt cagagatctg aatcccttct cagcatagtt tatgatttga aacagttaaa   1860

ggtgtataac atggaggcca ataagattag tatttgtaaa agatttacta atagttaggt   1920

gtatgagctc atgtctgcgc ttatgaatgc aaggcctcaa aagagaccag aagctgttgg   1980

gtccctgtag cttggagtta gggcagttag gaattgccaa gcagggtgag ccatctttgc   2040

aacccctcta tttttaatga agcagggcca tggagcccaa gctggccttg aacttctcag   2100

cttttgtgct ggtatcacag aaatgtggcg ctatgcccgg tcgggcctga tgttccagag   2160

tctttgcagt gtggggaact tgtaaggatg agactacaag acatcgggcc acatcgcctg   2220

ccactactta agtccgattc acttcggctt tagctccaag cctttaatct cgcgaagctc   2280

tttttttttt tttaacaaca taggagctgt gattggctgt tttcagccaa tcagcactga   2340

ctcatttgca tagcctttac aagcggtcac aaactcaaga aacgagcggt tttaatagtc   2400

ttttagaata ttgtttatcg aaccgaataa ggaactgtgc tttgtgattc acatatcagt   2460

ggaggggtgt ggaaatggca ccttgatctc accctcatcg aaagtggagt tgatgtcctt   2520

ccctggctcg ctacagacgc acttccgcaa gtgttacagc tcttttagaa tttgtctagc   2580

aggttttctg acttcggtcg gaaaacccct cccaatttca ctggtctaca atgaaagcaa   2640

aacagttctc ttccccgctc cccggtgtgt gagaggggct ttgatccttc tctggtttcc   2700

taggaaacgc gtatgtgcta gagccacgct ctgagacttc cgcctcgtgc ggtcccgctt   2760

cctttctgcc tcctctggcc tgcatccgtg ggggaggtgg ctggctgcag ggttctccgg   2820

atctcttctg tgttcccact actcaagcac cgagtggcgt tctatggcgt ccgcctcggc   2880

tcagcccgcg gccctgagcg cggagcaggc caagggtgag gaaagagcct agtctgggtg   2940

tgggccgtct tctgggggga gggcgcgata ctattctttg cctctccaag tggggccctt   3000

gcccattagg gcgaagggtt gggaggacaa gctt                               3034


<210>  11
<211>  407
<212>  DNA
<213>  mus musculus

<400>  11
taacaacata ggagctgtga ttggctgttt tcagccaatc agcactgact catttgcata     60

gcctttacaa gcggtcacaa actcaagaaa cgagcggttt taatagtctt ttagaatatt    120

gtttatcgaa ccgaataagg aactgtgctt tgtgattcac atatcagtgg aggggtgtgg    180

aaatggcacc ttgatctcac cctcatcgaa agtggagttg atgtccttcc ctggctcgct    240

acagacgcac ttccgcaaaa tttttggagc aggttttctg acttcggtcg gaaaacccct    300

cccaatttca ctggtctaca atgaaagcaa aacagttctc ttccccgctc cccggtgtgt    360

gagaggggct ttgatccttc tctggtttcc taggaaacgc gtatgtg                  407


<210>  12
<211>  447
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid  molecule encoding a mus musculus small nuclear 
       protein U7 linked with a nucleic acid molecule encoding a murine 
       BAFF antisense oligonucleotide

<400>  12
taacaacata ggagctgtga ttggctgttt tcagccaatc agcactgact catttgcata     60

gcctttacaa gcggtcacaa actcaagaaa cgagcggttt taatagtctt ttagaatatt    120

gtttatcgaa ccgaataagg aactgtgctt tgtgattcac atatcagtgg aggggtgtgg    180

aaatggcacc ttgatctcac cctcatcgaa agtggagttg atgtccttcc ctggctcgct    240

acagacgcac ttccgcaata tagtcggcgt gtcgctgtct gcaatcagct gcagacagaa    300

tttttggagc aggttttctg acttcggtcg gaaaacccct cccaatttca ctggtctaca    360

atgaaagcaa aacagttctc ttccccgctc cccggtgtgt gagaggggct ttgatccttc    420

tctggtttcc taggaaacgc gtatgtg                                        447


<210>  13
<211>  4450
<212>  DNA
<213>  artificial

<220>
<223>  AAV161

<400>  13
ctagagcatg gctacgtaga taagtagcat ggcgggttaa tcattaacta caaggaaccc     60

ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga    120

ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc    180

cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct    240

gaatggcgaa tggattccag acgattgagc gtcaaaatgt aggtatttcc atgagcgttt    300

ttccgttgca atggctggcg gtaatattgt tctggatatt accagcaagg ccgatagttt    360

gagttcttct actcaggcaa gtgatgttat tactaatcaa agaagtattg cgacaacggt    420

taatttgcgt gatggacaga ctcttttact cggtggcctc actgattata aaaacacttc    480

tcaggattct ggcgtaccgt tcctgtctaa aatcccttta atcggcctcc tgtttagctc    540

ccgctctgat tctaacgagg aaagcacgtt atacgtgctc gtcaaagcaa ccatagtacg    600

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta    660

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt    720

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg    780

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat    840

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac    900

tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag    960

ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg   1020

cgaattttaa caaaatatta acgtttacaa tttaaatatt tgcttataca atcttcctgt   1080

ttttggggct tttctgatta tcaaccgggg tacatatgat tgacatgcta gttttacgat   1140

taccgttcat cgattctctt gtttgctcca gactctcagg caatgacctg atagcctttg   1200

tagagacctc tcaaaaatag ctaccctctc cggcatgaat ttatcagcta gaacggttga   1260

atatcatatt gatggtgatt tgactgtctc cggcctttct cacccgtttg aatctttacc   1320

tacacattac tcaggcattg catttaaaat atatgagggt tctaaaaatt tttatccttg   1380

cgttgaaata aaggcttctc ccgcaaaagt attacagggt cataatgttt ttggtacaac   1440

cgatttagct ttatgctctg aggctttatt gcttaatttt gctaattctt tgccttgcct   1500

gtatgattta ttggatgttg gaatcgtcct gatgcggtat tttctcctta cgcatctgtg   1560

cggtatttca caccgcatat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt   1620

aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc   1680

ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc   1740

accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt   1800

taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg   1860

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca   1920

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt   1980

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga   2040

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga   2100

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat   2160

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca   2220

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt   2280

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac   2340

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct   2400

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga   2460

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac   2520

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat   2580

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg   2640

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc   2700

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc   2760

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg   2820

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta   2880

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg   2940

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga   3000

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt   3060

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag   3120

agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa   3180

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag   3240

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca   3300

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac   3360

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa   3420

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc   3480

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg   3540

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc   3600

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc   3660

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag   3720

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa   3780

accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tgcgcgctcg ctcgctcact   3840

gaggccgccc gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc   3900

gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctt gtagttaatg   3960

attaacccgc catgctactt atctacgtag ccatgctcta gccacatacg cgtttcctag   4020

gaaaccagag aaggatcaaa gcccctctca cacaccgggg agcggggaag agaactgttt   4080

tgctttcatt gtagaccagt gaaattggga ggggttttcc gaccgaagtc agaaaacctg   4140

ctccaaaaat ttacttttca gtcattcaag actgtctgca gctgattgca gttgcggaag   4200

tgcgtctgta gcgagccagg gaaggacatc aactccactt tcgatgaggg tgagatcaag   4260

gtgccatttc cacacccctc cactgatatg tgaatcacaa agcacagttc cttattcggt   4320

tcgataaaca atattctaaa agactattaa aaccgctcgt ttcttgagtt tgtgaccgct   4380

tgtaaaggct atgcaaatga gtcagtgctg attggctgaa aacagccaat cacagctcct   4440

atgttgttat                                                          4450


<210>  14
<211>  4450
<212>  DNA
<213>  artificial

<220>
<223>  AAV162

<400>  14
ctagagcatg gctacgtaga taagtagcat ggcgggttaa tcattaacta caaggaaccc     60

ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga    120

ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc    180

cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct    240

gaatggcgaa tggattccag acgattgagc gtcaaaatgt aggtatttcc atgagcgttt    300

ttccgttgca atggctggcg gtaatattgt tctggatatt accagcaagg ccgatagttt    360

gagttcttct actcaggcaa gtgatgttat tactaatcaa agaagtattg cgacaacggt    420

taatttgcgt gatggacaga ctcttttact cggtggcctc actgattata aaaacacttc    480

tcaggattct ggcgtaccgt tcctgtctaa aatcccttta atcggcctcc tgtttagctc    540

ccgctctgat tctaacgagg aaagcacgtt atacgtgctc gtcaaagcaa ccatagtacg    600

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta    660

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt    720

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg    780

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat    840

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac    900

tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag    960

ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg   1020

cgaattttaa caaaatatta acgtttacaa tttaaatatt tgcttataca atcttcctgt   1080

ttttggggct tttctgatta tcaaccgggg tacatatgat tgacatgcta gttttacgat   1140

taccgttcat cgattctctt gtttgctcca gactctcagg caatgacctg atagcctttg   1200

tagagacctc tcaaaaatag ctaccctctc cggcatgaat ttatcagcta gaacggttga   1260

atatcatatt gatggtgatt tgactgtctc cggcctttct cacccgtttg aatctttacc   1320

tacacattac tcaggcattg catttaaaat atatgagggt tctaaaaatt tttatccttg   1380

cgttgaaata aaggcttctc ccgcaaaagt attacagggt cataatgttt ttggtacaac   1440

cgatttagct ttatgctctg aggctttatt gcttaatttt gctaattctt tgccttgcct   1500

gtatgattta ttggatgttg gaatcgtcct gatgcggtat tttctcctta cgcatctgtg   1560

cggtatttca caccgcatat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt   1620

aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc   1680

ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc   1740

accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt   1800

taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg   1860

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca   1920

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt   1980

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga   2040

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga   2100

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat   2160

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca   2220

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt   2280

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac   2340

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct   2400

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga   2460

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac   2520

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat   2580

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg   2640

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc   2700

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc   2760

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg   2820

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta   2880

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg   2940

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga   3000

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt   3060

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag   3120

agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa   3180

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag   3240

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca   3300

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac   3360

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa   3420

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc   3480

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg   3540

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc   3600

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc   3660

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag   3720

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa   3780

accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tgcgcgctcg ctcgctcact   3840

gaggccgccc gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc   3900

gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctt gtagttaatg   3960

attaacccgc catgctactt atctacgtag ccatgctcta gataacaaca taggagctgt   4020

gattggctgt tttcagccaa tcagcactga ctcatttgca tagcctttac aagcggtcac   4080

aaactcaaga aacgagcggt tttaatagtc ttttagaata ttgtttatcg aaccgaataa   4140

ggaactgtgc tttgtgattc acatatcagt ggaggggtgt ggaaatggca ccttgatctc   4200

accctcatcg aaagtggagt tgatgtcctt ccctggctcg ctacagacgc acttccgcaa   4260

tatagtcggc gtgtcgctgt ctgcaatcag ctgcagacag aatttttgga gcaggttttc   4320

tgacttcggt cggaaaaccc ctcccaattt cactggtcta caatgaaagc aaaacagttc   4380

tcttccccgc tccccggtgt gtgagagggg ctttgatcct tctctggttt cctaggaaac   4440

gcgtatgtgg                                                          4450


<210>  15
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  15
gtagccatgc tctagccaca                                                 20


<210>  16
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  16
cggtgtgtga gaggggcttt g                                               21


<210>  17
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  17
ctaggaaacc agagaag                                                    17


<210>  18
<211>  57
<212>  DNA
<213>  artificial

<220>
<223>  DNA coding for exon 3 of human BAFF

<400>  18
tcactcaaga ctgcttgcaa ctgattgcag acagtgaaac accaactata caaaaag        57


<210>  19
<211>  57
<212>  DNA
<213>  artificial

<220>
<223>  DNA coding for exon 4 of murine BAFF

<400>  19
tcattcaaga ctgtctgcag ctgattgcag acagcgacac gccgactata cgaaaag        57


<210>  20
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid molecule encoding a human BAFF antisense

<400>  20
ctgcttgcaa ctgattgcag acagtgaaac accaactata                           40


<210>  21
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  21
aatagcctgt ttgcctcacc                                                 20


<210>  22
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  22
gactgtctgc agctgatttg c                                               21


<210>  23
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  23
ggaatgaacc tcagaaacaa acttac                                          26


<210>  24
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  24
ccgtgtatag aacctggctg tag                                             23


<210>  25
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  25
catcactccg cagaaggag                                                  19


<210>  26
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  26
ggaattgttg ggcagtgttt                                                 20


<210>  27
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  27
agacagtgaa acaccaacta ta                                              22


<210>  28
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  28
ggcgtaggtc ttatcagt                                                   18


<210>  29
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  29
agaagaaaca ggatcttaca ca                                              22


<210>  30
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  30
tggcgtaggt cttatcagt                                                  19


