SEQUENCE LISTING


<110>  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       ELRO PHARMA
       UNIVERSITE PARIS 12 - VAL DE MARNE
       ZIMMER, Robert
       COURTY, Jose
 
<120>  COMPOSITIONS COMPRISING MULTIVALENT SYNTHETIC LIGANDS OF SURFACE 
       NUCLEOLIN AND GLYCOSAMINOGLYCANS

<130>  359557D30161

<150>  US 61/389,519
<151>  2010-10-04

<160> 25     

<170> PatentIn version 3.3


<210> 1
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<400> 1

Lys Lys Lys Gly Pro Lys Glu Lys Gly Cys 
1               5                   10  


<210> 2
<211> 6
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<400> 2

Lys Lys Lys Lys Gly Cys 
1               5       


<210> 3
<211> 12
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<400> 3

Lys Lys Lys Lys Gly Pro Lys Lys Lys Lys Gly Ala 
1               5                   10          


<210> 4
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide


<220>
<221> MOD_RES
<222> (9)
<223> Xaa is (2S)-2-aminohexanamide

<400> 4

Lys Lys Lys Gly Pro Lys Glu Lys Xaa
1               5               


<210> 5
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide


<220>
<221> BINDING
<222> (1)
<223> Lysinyl proline

<220>
<221> BINDING
<222> (3)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (5)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (8)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (10)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> MOD_RES
<222> (11)
<223> Xaa is (2S)-2-aminohexanamide

<400> 5

Pro Arg Lys Lys Lys Gly Pro Lys Glu Lys Xaa
1               5                   10    


<210> 6
<211> 4
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (1)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (3)
<223> Aib (2-aminoisobutyric acid) 

<400> 6

Xaa Lys Xaa Gly 
1               


<210> 7
<211> 3
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (2)
<223> Aib (2-aminoisobutyric acid) 

<400> 7

Lys Xaa Gly 
1               


<210> 8
<211> 20
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (1)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (3)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (5)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (7)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (9)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (11)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (13)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (15)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (17)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (19)
<223> Aib (2-aminoisobutyric acid) 


<400> 8

Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly
1               5                   10                  15                  20 


<210> 9
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (2)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (5)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (8)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (11)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (14)
<223> Aib (2-aminoisobutyric acid) 


<400> 9

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly
1               5                   10                  15               


<210> 10
<211> 20
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (1)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (3)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (5)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (7)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (9)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (11)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (13)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (15)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (17)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (19)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> BINDING
<222> (2)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (6)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (10)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (14)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (18)
<223> N6-Arg-Pro-Lysinyl

<400> 10

Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly
1               5                   10                  15                  20 


<210> 11
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (2)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (5)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (8)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (11)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (14)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> BINDING
<222> (1)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (4)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (7)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (10)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (13)
<223> N6-Arg-Pro-Lysinyl

<400> 11

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly
1               5                   10                  15  


<210> 12
<211> 5
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<400> 12

Lys Ala Lys Pro Gly 
1               5   


<210> 13
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (1)
<223> Acetyl lysine

<220>
<221> MOD_RES
<222> (15)
<223> Amide glycine


<400> 13

Lys Ala Lys Pro Gly Lys Ala Lys Pro Gly Lys Ala Lys Pro Gly 
1               5                   10                  15  


<210> 14
<211> 24
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (1)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (3)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (5)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (7)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (9)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> VARIANT
<222> (11)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (13)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (15)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (16)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (17)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (21)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (23)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (1)
<223> Acetyl lysine

<220>
<221> MOD_RES
<222> (24)
<223> Amide glycine

<400> 14

Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly 
1               5                   10                  15      
Xaa Lys Xaa Gly Xaa Lys Xaa Gly 
            20                  


<210> 15
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (2)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (5)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (8)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (11)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (14)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (17)
<223> Aib (2-aminoisobutyric acid) 


<220>
<221> MOD_RES
<222> (1)
<223> Acetyl lysine

<220>
<221> MOD_RES
<222> (18)
<223> Amide glycine

<400> 15

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys 
1               5                   10                  15      
Xaa Gly 
        


<210> 16
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (2)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (5)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (8)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> VARIANT
<222> (11)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (14)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (17)
<223> Aib (2-aminoisobutyric acid) 


<220>
<221> MOD_RES
<222> (1)
<223> Acetyl lysine

<220>
<221> BINDING
<222> (1)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (4)
<223> LYS-X-PRO-ARG-LYS. X is the (-CH2NH-) binding


<220>
<221> BINDING
<222> (7)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (10)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (13)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (16)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> MOD_RES
<222> (18)
<223> Amide glycine

<400> 16

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys 
1               5                   10                  15      
Xaa Gly 
        


<210> 17
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (1)
<223> Acetyl lysine

<220>
<221> BINDING
<222> (1)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (3)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (6)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (8)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (11)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (13)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> MOD_RES
<222> (15)
<223> Amide glycine

<400> 17

Lys Ala Lys Pro Gly Lys Ala Lys Pro Gly Lys Ala Lys Pro Gly 
1               5                   10                  15  


<210> 18
<211> 20
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (1)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (3)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (5)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (7)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (9)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (11)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (13)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (15)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (17)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (19)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (1)
<223> Acetyl lysine

<220>
<221> MOD_RES
<222> (20)
<223> Amide glycine

<400> 18

Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly
1               5                   10                  15                  20 


<210> 19
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (2)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (5)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (8)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (11)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (14)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (1)
<223> Acetyl lysine

<220>
<221> MOD_RES
<222> (15)
<223> Amide glycine

<400> 19

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly
1               5                   10                  15               


<210> 20
<211> 20
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (1)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (3)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (5)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (7)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (9)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (11)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (13)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (15)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (17)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (19)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (1)
<223> Acetyl lysine

<220>
<221> BINDING
<222> (2)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (6)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (10)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (14)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (18)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> MOD_RES
<222> (20)
<223> Amide glycine

<400> 20

Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly
1               5                   10                  15                  20 


<210> 21
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> Synthetic peptide

<220>
<221> MOD_RES
<222> (2)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (5)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (8)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (11)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (14)
<223> Aib (2-aminoisobutyric acid) 

<220>
<221> MOD_RES
<222> (1)
<223> Acetyl lysine

<220>
<221> BINDING
<222> (1)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (4)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (7)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (10)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> BINDING
<222> (13)
<223> N6-Arg-Pro-Lysinyl

<220>
<221> MOD_RES
<222> (15)
<223> Amide glycine

<400> 21

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly
1               5                   10                  15  

<210>  22
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Acetyl Lysine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Amide glycine

<400>  22

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly 
1               5                   10          


<210>  23
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Acetyl lysine

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Amide glycine

<400>  23

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly 
1               5                   10          


<210>  24
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Acetyl Lysine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Amide glycine

<400>  24

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys 
1               5                   10                  15      


Xaa Gly Lys Xaa Gly Lys Xaa Gly 
            20                  


<210>  25
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Acetyl lysine

<220>
<221>  BINDING
<222>  (1)..(1)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  BINDING
<222>  (4)..(4)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  BINDING
<222>  (7)..(7)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  BINDING
<222>  (10)..(10)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  BINDING
<222>  (13)..(13)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  BINDING
<222>  (16)..(16)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  BINDING
<222>  (19)..(19)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  BINDING
<222>  (22)..(22)
<223>  N6-Arg-Pro-Lysinyl

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Aib (2-aminoisobutyric acid)

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Amide glycine

<400>  25

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys 
1               5                   10                  15      


Xaa Gly Lys Xaa Gly Lys Xaa Gly 
            20                  






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