                         SEQUENCE LISTING

<110>  CROW, JR., JAMES E.
       KRAUSE, JENS C.
       BLUM, DAVID L.
 
<120>  INFLUENZA VIRUS ANTIBODIES AND IMMUNOGENS AND USES THEREFOR

<130>  VBLT.P0185WO

<140>  UNKNOWN
<141>  2011-09-30

<150>  61/388,393
<151>  2010-09-30

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Phe Ser Gly Ser Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Pro Gly Pro Tyr Ile Val Val Ala Gly Leu Phe Glu Asn 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
        115                 120         


<210>  2
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  2
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cgcctttagc agctatggca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagca tttagtggaa gtggtactag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca aatccaagaa cactctgtat      240

ctgcaaatga acagcctgag agccgaagac acggccattt attactgtgc gaagcccccg      300

gggccctata tagtagtggc tggtcttttt gaaaactggg gccggggaac cctggtcacc      360

gtctcc                                                                 366


<210>  3
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Asp Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  4
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  4
gaaattgtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagtcacc       60

ctctcctgca gggccagtca gagtattacc gacggcttag cctggtacca gcagaaatct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctccggt aacgttcggc      300

caagggacca aggtggagat caaacgtacg                                       330


<210>  5
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Glu Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Asp Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Ala Arg Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Tyr Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ile Ile Trp Ser Ser Ser Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser 
        115             


<210>  6
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  6
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcagc agatactata tacactgggt gcgacaggcc      120

cctggacaag agcttgagtg gatgggatgg atcaaccctg acagtggtga cacaaactat      180

gcacagaagt ttcggggccg ggtcaccatg gccagggaca cgtccatcag cacagtctac      240

atggagttga acagcctgag atatgacgac acggccgtgt atttttgtgc aagaatcatt      300

tggagttctt ccggtatgga cgtctggggc caagggacca cggtcaccgt ctct            354


<210>  7
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys His Leu Tyr Val Gly Ser 
                85                  90                  95      


Ser Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Ala Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Lys Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Pro Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  8
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  8
cagtctgccc tgactcagcc tgcctctgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg agttataatc ttgtctcctg gtatcaacaa      120

cacccaggca aggcccccaa actgatgatt tatgaggtca gtaagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg acgaggctga ttattactgc cacttatatg taggtagtag taactgggtg      300

ttcggcggag ggaccaagct ggccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccac cctcctctaa ggagcttcaa gccaacaagg ccacactggt gtgtcccata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tacctgagcc tgacgcctga gcagtggaag tcccacaaaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcata g               651


<210>  9
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Phe Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Pro Tyr Cys Gly Gly Asp Cys Phe Ala Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser 
        115                 120         


<210>  10
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  10
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt aactatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactt atatcatttg atggaagcga taaatactac      180

gcagactccg tgaagggccg attcaccatg tccagagaca attccaagaa caccctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatgag      300

ccatattgtg gtggtgactg cttcgctttt gatgtctggg gccaagggac aatggtcacc      360

gtctct                                                                 366


<210>  11
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Ser Met Thr Cys Arg Ala Ser Gln Ile Ile Ser Ser Ser 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Glu Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr 
            100                 105                 110     


<210>  12
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  12
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgccggaga cagagtcagc       60

atgacttgcc gggcaagtca gatcattagt agttccttaa attggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctatgct gcatccaatt tacaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgga gctcactttc      300

ggcggaggga ccaaagtgga tatcaaacgt acg                                   333


<210>  13
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Asn Tyr Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Cys Ile 
        35                  40                  45              


Gly Tyr Ile Ser Asp Thr Gly Arg Thr Tyr Tyr Asn Pro Ser Leu Arg 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Pro Thr Gly Ser Arg Gln Lys Asn Ala Phe Asp Met Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser 
        115                 120 


<210>  14
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  14
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cttgtccctc       60

acctgctctg tctctggtgg ctccatcaat tattattact ggagctggat ccggcagccc      120

cccgggaagg gactggagtg cattggctat atctctgaca ctgggagaac ctactacaac      180

ccctccctca ggagtcgagt caccatatca gtagacacct ccaagaacca gttctccctt      240

aacctgacct ctatgaccgc tgcggacaca gccgtgtatt actgtgcgag agaccctact      300

gggagccgcc aaaaaaatgc ttttgatatg tggggccaag ggacaatggt caccgtgtct      360


<210>  15
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Gly Thr Thr Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr His Thr Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  16
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  16
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gaatattagg agttacttaa attggtatca gcagaagcca      120

gggaaagccc ctaacctcct gatttatggt accaccagtt tggagagtgg ggtcccatca      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg cgacttacta ctgtcaacag agttaccata cccctcaaac gttcggccaa      300

gggaccaagg tggagatcaa acgtacg                                          327


<210>  17
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser His Asp Gly Asn Leu Lys Tyr Tyr Gly Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Gly Ile Thr Asp Ala Phe Asp Ile Arg Gly Gln Gly 
            100                 105                 110         


Thr Met Val Val Val Ser 
        115             


<210>  18
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  18
gaggtgcagc tgttggagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggctt cacctttagg acctatggca tgcactgggt ccgccaggct      120

cctggcaagg ggctggagtg ggtggcagtc atctcacatg atggaaattt aaaatattat      180

ggaggctctg tgaagggccg attcaccatc tccagagaca attccaagaa cgcgctgtat      240

ttgcaaatga acagcctgag agttgacgac acggctctgt attactgtgc gagaggtatc      300

ggtataaccg atgcttttga tatccggggc caagggacaa tggtcgtcgt ctct            354


<210>  19
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Trp Met Met Leu Leu Leu Thr Leu Leu Ile His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala 
            20                  25                  30          


Pro Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Lys Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr 
                85                  90                  95      


Gly Leu Gln Thr Gly Asp Glu Ala Asp Tyr His Cys Gly Ala Trp Asp 
            100                 105                 110         


Ser Ser Leu Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  20
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  20
atggcctgga tgatgcttct cctcaccctt ctcattcact gcacagggtc ctgggcccag       60

tctgtgttga cgcagccgcc ctcagtgtct gcggccccag gacagaaggt caccatctcc      120

tgttctggaa gcagctccaa cattgggaaa aattatgtat cctggtacca gcaactccca      180

ggaacagccc ccaaactcct catttatgac aatgataagc gaccctcagg gattcctgac      240

cgattctctg gctccaagtc tggcacgtca gccaccctgg gcatcaccgg actccagact      300

ggggacgagg ccgattatca ctgcggagca tgggatagca gtctgaatgg gggggtgttc      360

ggcggaggga ccaaggtgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      420

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      480

gacttctacc cgggagccgt gacagtggcc tggaaggcag atagcagccc cgtcaaggcg      540

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctac      600

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      660

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttcatag                   708


<210>  21
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Ala Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Asp Leu Pro Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Gly Arg Gly Tyr Tyr Leu Gly Gly Asp Tyr Gly Ser Leu Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120             


<210>  22
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  22
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggagg caccttcaga agctatgctg tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcattgcta tctttggaac aacaaactac      180

gcacagaagt tccaggacag agtcacgatt accgcggacg atctcccgag cacagcctac      240

atggagttga ccagcctgag atctgaggac acggccgttt atttctgtgt gagagggcgt      300

ggatattacc tgggcggtga ctacgggtcc cttgactcct ggggccaggg aaccctggtc      360

accgtctcc                                                              369


<210>  23
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asp Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr 
            100                 105                 


<210>  24
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  24
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagaatcacc       60

atcacttgcc gggcgagtca gggcattgac aattatttag cctggtttca gcagaaacca      120

gggaaagttc ctgagctcct gatttatgct gcatccactc tgcaatcagg ggtcccatct      180

cggttcagcg gcagtggatc tgggacggga ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tatgacagtg ccccgctcac tttcggcgga      300

gggaccaaag tggatatcaa acgtacg                                          327


<210>  25
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Ala Gly Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asn Thr Phe Ser Ser Asn 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Leu Gly Met Leu Arg Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Phe Met Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Gly Tyr Tyr Pro Asp Tyr Phe His Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  26
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  26
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cgcctttagc agctatggca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagca tttagtggaa gtggtactag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca aatccaagaa cactctgtat      240

ctgcaaatga acagcctgag agccgaagac acggccattt attactgtgc gaagcccccg      300

gggccctata tagtagtggc tggtcttttt gaaaactggg gccggggaac cctggtcacc      360

gtctcc                                                                 366


<210>  27
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Asp Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  28
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  28
gaaattgtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagtcacc       60

ctctcctgca gggccagtca gagtattacc gacggcttag cctggtacca gcagaaatct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctccggt aacgttcggc      300

caagggacca aggtggagat caaacgtacg                                       330


<210>  29
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Asn Phe Asp Gly Tyr 
            20                  25                  30          


Ala Met Gln Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp His Ser Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Gly Lys Ser Ile Gly His Val Gly Gly Ser Tyr Arg His Pro Ile Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120             


<210>  30
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  30
gaggtgcagc tggtggagtc tgggggaggc ttagtccagc ctggcaggtc cctgagactc       60

tcctgtgtag ggtctggatt caactttgat ggatatgcca tgcagtgggt ccggcaagtt      120

ccagggaagg gcctggagtg ggtctcaggt attagttggc acagtgatag tactggctat      180

gcggactctg tgaggggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ttgcaaatgg acagtctgag acctgaggac acggccttct attactgtgg aaaatccatc      300

ggccatgttg gaggcagtta tcgacatccc attgactact ggggccaggg aaccctggtc      360

accgtctcc                                                              369


<210>  31
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  31

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Thr Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  32
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  32
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca gggcattacc gattatttag cctggtatca gcagaaacca      120

gggacaattc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcggtggata tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tataacagtg ccccgctcac tttcggcgga      300

gggaccaagg tggaaatcaa acgtacg                                          327


<210>  33
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Thr Pro Thr Ser Gly Lys Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Met Thr Arg Asn Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Pro Glu Arg Arg Thr Thr Ile Phe Asp Val Ile Leu Asp 
            100                 105                 110         


Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125     


<210>  34
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  34
gaggtgcagc tggtggagtc tggggctgaa gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgtaagg cttctggata caccttcacc agttttgata ttaactgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggatgg atgaccccaa ccagtggaaa gacaggctac      180

gcacagaagt tccagggcag aatcaccatg accaggaaca cctccataaa tacagcctac      240

atggagttga gcagcctgag atctgaggac acggccgtat atttctgtgc gagaggcccc      300

gagagacgta ctacaatttt tgacgtgatt ctggactggt tcgatccctg gggccaggga      360

accctggtca ccgtctcc                                                    378


<210>  35
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Ile Val Met Thr Gln Ser Pro Phe Ser Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ser Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Met Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  36
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  36
gacatcgtga tgacccagtc tccattctcc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattagc aactacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat tcatccaaca gggccactgg cgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggatgtacac ttttggccag      300

gggaccaagg tggaaatcaa acgtacg                                          327


<210>  37
<211>  118
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Asn Val Ser Gly Asp Ser Ile Asn Xaa Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Glu Met Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Ile Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Asp Tyr Asp Ser Gly Gly Ser Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  38
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  38
caggtgcagc tgcaggagtc gggcccaggg ctggtgaggc cttcggagac cctgtccctc       60

acctgcaatg tctctggtga ctccatcaat gattactact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtac atctattaca gtgggagcac caactacaac      180

ccctccctca acagtcgagt caccatttcg gtagaaatgt ccaagaacca gttctccctg      240

attctgaact ctgtgaccgc tgcggacacg gccgtgtatt actgtgccag agtggactat      300

gatagtggtg ggtctttcga cccctggggc cagggaaccc tggtcaccgt ctcc            354


<210>  39
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Trp Met Met Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Phe Tyr Cys Gln Ser Tyr 
            100                 105                 110         


Asp Ser Arg Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  40
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  40
atggcctgga tgatgcttct cctcactctc ctcgctcact gcacagggtc ctgggcccag       60

tctgtgctga cgcagccgcc ctcagtgtct ggggccccag ggcagagggt caccatctcc      120

tgcactggga gcagctccaa catcggggca ggatatgatg ttcactggta ccagcaactt      180

ccaggaacag cccccaaact cctcatctat ggtaacagca atcggccctc aggggtccct      240

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcac tgggctccag      300

gctgaggatg aggctgattt ttactgccag tcctatgaca gcagactgag tggttatgtc      360

ttcggaactg ggaccaaggt caccgtccta ggtcagccca aggccaaccc cactgtcact      420

ctgttcccgc cctcctctga ggagctccaa gccaacaagg ccacactagt gtgtctgatc      480

agtgacttct acccgggagc tgtgacagtg gcctggaagg cagatggcag ccccgtcaag      540

gcgggagtgg agaccaccaa accctccaaa cagagcaaca acaagtacgc ggccagcagc      600

tacctgagcc tgacgcccga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      660

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcata g               711


<210>  41
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Phe Ser Gly Ser Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Pro Gly Pro Tyr Ile Val Val Ala Gly Leu Phe Glu Asn 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
        115                 120         


<210>  42
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  42
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cgcctttagc agctatggca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagca tttagtggaa gtggtactag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagata aatccaagaa cactctgtat      240

ctgcaaatga acagcctgag agccgaagac acggccattt attactgtgc gaagcccccg      300

gggccctata tagtagtggc tggtcttttt gaaaactggg gccggggaac cctggtcacc      360

gtctcc                                                                 366


<210>  43
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Glu Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Ile Ile Asn Ala Asn Thr Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe 
            100                 105                 110         


Asp Ser Ser Leu Ser Gly Trp Leu Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  44
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  44
atggcctggg ctcttctcct cctcactctc ctcgctcact gcacagggtc ctgggcccag       60

tctgtgctga cgcagccgcc ctcagtgtct ggggccccag ggcagagggt caccatctcc      120

tgcactggga ccagctccaa catcggggcc ggctatgaag tacactggta ccagcaactt      180

ccaggaacag cccccaaact catcatcaat gctaatacca atcggccctc aggggtccct      240

gaccgattct ctggctccca gtctggcacc tcagcctccc tggccatcac tggtctccgg      300

gctgaggatg aggctgatta ttactgccag tcctttgaca gcagcctgag tggttggctg      360

ttcggcggag ggaccaaact gaccgtccta ggtcagccca aggctgcccc ctcggtcact      420

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      480

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      540

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      600

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      660

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcata g               711


<210>  45
<211>  128
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Val Gln Leu Leu Glu Ser Gly Gly Xaa Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Met Phe Ser Ser Tyr Val 
            20                  25                  30          


Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Val Ile Trp Tyr Asp Gly Ser Lys Thr Tyr Phe Ala Asp Ser Met Arg 
    50                  55                  60                  


Gly Arg Leu Thr Val Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gln Gln Asp Ser Gly Tyr Ser Gly Pro Glu Val Ser Tyr Tyr Ser 
            100                 105                 110         


His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Ile Val Ser 
        115                 120                 125             


<210>  46
<211>  387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n is a, c, g, or t

<400>  46
gaggtgcagc tgttggagtc tgggggaggn gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt catgttcagc agttatgtca tgcactgggt ccgccagcct      120

ccaggcaagg ggctggagtg ggtggctgtt atatggtatg atggaagtaa gacttatttc      180

gcagactcca tgaggggccg actcaccgtc tccagagaca attccaagaa cgcgctgtat      240

ctccaaatga acagactgag agccgaggac acggctgtgt attactgtgc gagacagcag      300

gatagtggat atagtggccc agaagtctct tattattctc attatggtat ggacgtctgg      360

ggccaaggga ccacggtcat cgtctcc                                          387


<210>  47
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Trp Ala Pro Leu Leu Leu Thr Leu Leu Thr His Cys Ala Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr 
            20                  25                  30          


Pro Gly Arg Ala Ile Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ser Asn Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Asp Glu His Arg Pro Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Pro Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
                85                  90                  95      


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
            100                 105                 110         


Asp Ser Leu Ser Gly Pro Ala Val Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         


<210>  48
<211>  731
<212>  DNA
<213>  Homo sapiens

<400>  48
aagcttgcca ccatggcctg ggctccgctc ctcctcaccc tcctcactca ctgtgcaggg       60

tcctgggccc agtctgtgct gactcagtca ccctcagcgt ctgggacccc cgggcgggca      120

atcaccatct cttgttctgg aagcagctcc aacatcggaa gtaatcctgt aaattggtat      180

cagcaactcc caggagcggc ccccaaactc ctcatctatg ctgatgaaca ccggccctca      240

ggggtccctg accgattctc tggccccaag tctggcacct cagcctccct ggccatcagt      300

gggctccagt ctgaggatga ggctgattat tattgtgcag catgggatga cagcctgagt      360

ggtccggctg tggttttcgg cggggggacc aagctgaccg tcctaggtca gcccaaggct      420

gccccctcgg tcactctgtt cccgccctcc tctgaggagc ttcaagccaa caaggccaca      480

ctggtgtgtc tcataagtga cttctacccg ggagccgtga cagtggcctg gaaggcagat      540

agcagccccg tcaaggcggg agtggagacc accacaccct ccaaacaaag caacaacaag      600

tacgcggcca gcagctatct gagcctgacg cctgagcagt ggaagtccca cagaagctac      660

agctgccagg tcacgcatga agggagcacc gtggagaaga cagtggcccc tacagaatgt      720

tcatagaatt c                                                           731


<210>  49
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Tyr Asn Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Val Tyr Tyr Ser Gly Ser Thr Tyr Phe Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Ile Ala Phe Tyr Tyr Asp Thr Asn Gly Tyr Thr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120     


<210>  50
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  50
caggtgcagt tgaaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtaact acaactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtgtct attatagtgg gagcacctac      180

ttcaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgacctctgt gaccgccgcg gacacggctg tgtattactg tgccagacta      300

atagcatttt actatgatac caatggttat acttggggcc agggaaccct ggtcaccgtc      360

tcc                                                                    363


<210>  51
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  51

Asn Ser Ile Met Thr Gln Ser Pro Phe Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Pro Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Phe Ala Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  52
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  52
aattcgatta tgacccagtc tccattcacc ctgtctgcgt ctgtaggaga caaagtcacc       60

atcacttgcc gggccagtca gagtattagt ccctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctataag gcatctagtt tagaaactgg ggtcccatca      180

agattcagcg gcagtgaatc tgggacagaa ttcactctca ccatcagcgg cctgcagcct      240

gatgattttg caacttatta ctgccaacag tattctagtt ttgcaaggac gttcggccaa      300

gggaccaagg tggaaatcaa acgaact                                          327


<210>  53
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  53

Gln Val Gln Leu Gln Glu Ser Ala Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Leu Ser Ser Ser 
            20                  25                  30          


Asp Trp Trp Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile His His Gly Gly Ser Thr Asn Ser Asn Pro Ser Leu 
    50                  55                  60                  


Gln Ser Arg Val Thr Ile Ser Ile Asp Lys Ser Lys Lys Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Thr Ser Val Thr Val Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Gly Ala Asp Ala Gly Pro Tyr Ser Glu Asn Ile His 
            100                 105                 110         


His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120             


<210>  54
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  54
caggtgcagc tgcaggagtc ggccccgggc ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgc ctccctcagc agttctgact ggtggacttg ggtccgccag      120

cccccaggca agggcctgga gtggattggg gaaatccatc atggaggcag taccaactcc      180

aacccgtccc tccagagtcg agtcaccata tccatagaca agtccaagaa gcagttctcc      240

ctgaagttga cctctgtgac cgtcgcagac acggccgtct attactgtgc gcgagccccc      300

ggcgccgatg ctggtcctta ctcggaaaac atccaccact ggggccaggg caccctggtc      360

accgtctcc                                                              369


<210>  55
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Leu His Cys Thr Gly 
1               5                   10                  15      


Ser Leu Ser Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser 
            20                  25                  30          


Leu Gly Ala Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Arg His Ser 
        35                  40                  45              


Asp Tyr Ala Ile Gly Trp His Gln Gln Gln Pro Gly Lys Gly Pro Arg 
    50                  55                  60                  


Tyr Leu Met Lys Leu Asn Pro Asp Gly Ser His Thr Lys Gly Asp Gly 
65                  70                  75                  80  


Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Leu Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
            100                 105                 110         


Thr Trp Gly Thr Gly Ile Gln Val Phe Gly Gly Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Ile Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Val Asp Ser 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  56
<211>  728
<212>  DNA
<213>  Homo sapiens

<400>  56
aagcttgcca ccatggcctg ggctctgctg ctcctcaccc tcctcctcca ctgcacaggg       60

tctctctccc agcttgtgct gactcaatcg ccctctgcct ctgcctccct gggagcctcg      120

gtcaagctca cctgcactct gagcagtaga cacagcgact acgccatcgg atggcatcag      180

cagcagccag ggaagggccc tcgttacttg atgaagctta accctgatgg cagccacacc      240

aagggggacg ggatccctga tcgcttctca ggctccagtt ctggggctga gcgctacctc      300

accatctcca acctcctgtc tgaggatgag gctgactatt actgtcagac ctggggcact      360

ggcattcagg tgttcggcgg agggacccgg ctgaccgtca taagtcagcc caaggctgcc      420

ccctcggtca ctctgttccc gccctcctct gaggagcttc aagccaacaa ggccacactg      480

gtgtgtctca taagtgactt ctacccggga gccgtgacag tggcctggaa ggtagatagc      540

agccccgtca aggcgggagt ggagaccacc acaccctcca aacaaagcaa caacaagtac      600

gcggccagca gctacctgag cctgacgcct gagcagtgga agtcccacaa aagctacagc      660

tgccaggtca cgcatgaagg gagcaccgtg gagaagacag tggcccctac agaatgttca      720

tagaattc                                                               728


<210>  57
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Phe Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Pro Tyr Cys Gly Gly Asp Cys Phe Ala Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser 
        115                 120         


<210>  58
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  58
gaagtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt aactatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactt atatcatttg atggaagcga taaatactac      180

gcagactccg tgaagggccg attcaccatg tccagagaca attccaagaa caccctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatgag      300

ccatattgtg gtggtgactg cttcgctttt gatgtctggg gccaagggac aatggtcacc      360

gtctct                                                                 366


<210>  59
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ala Asn Asn Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr 
            100                 105                 110         


Asp Ser Ser Leu Ser Gly Gly Val Phe Gly Thr Gly Thr Thr Val Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Gly Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  60
<211>  728
<212>  DNA
<213>  Homo sapiens

<400>  60
aagcttgcca ccatggcctg ggctctgctg cttctcactc tcctcgctca ctgcacaggg       60

tcctgggccc agtctgtgct gacgcagccg ccctcagtgt ctggggcccc agggcagagg      120

gtcaccatct cctgcactgg gagcagctcc aacatcgggg caggttatga tgtacactgg      180

taccagcagc ttccaggaac agcccccaaa ctcctcatct atgctaacaa caatcggccc      240

tcaggggtcc ctgaccgatt ctctggctcc aagtctggca cctcagcctc cctggccatc      300

actgggctcc aggctgagga tgaggctgat tattactgcc agtcctatga cagcagcctg      360

agtggagggg tcttcggaac tgggaccacg gtcaccgtcc taggtcagcc caaggccaac      420

cccactgtca ctctgttccc gccctcctct gaggagctcc aagccaacaa ggccacacta      480

gtgtgtctga tcagtgactt ctacccggga gctgtgacag tggcctggaa ggcagatggc      540

agccccgtca aggcgggagt ggagaccacc aaaccctcca aacagagcaa caacaagtac      600

gcggccagca gctacctgag cctgacgccc gagcagtgga agtcccacgg aagctacagc      660

tgccaggtca cgcatgaagg gagcaccgtg gagaagacag tggcccctac agaatgttca      720

tagaattc                                                               728


<210>  61
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  61

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Trp Ala Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly 
            20                  25                  30          


Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu 
        35                  40                  45              


Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr 
    50                  55                  60                  


Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Ser Gly Arg Leu Val 
65                  70                  75                  80  


Pro Arg Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
                85                  90                  95      


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
            100                 105                 110         


Phe Leu Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        115                 120                 125 


<210>  62
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  62

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Trp Ala Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            20                  25                  30          


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        35                  40                  45              


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    50                  55                  60                  


Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Ser Gly Arg Leu Val 
65                  70                  75                  80  


Pro Arg Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
                85                  90                  95      


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
            100                 105                 110         


Phe Leu Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        115                 120                 125 


<210>  63
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  63

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Trp Ala Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly 
            20                  25                  30          


Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu 
        35                  40                  45              


Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr 
    50                  55                  60                  


Glu Lys Val Lys Ser Gln Leu Lys Asn Met Lys Gln Ile Glu Asp Lys 
65                  70                  75                  80  


Ile Glu Glu Ile Leu Ser Lys Ile Tyr His Ile Glu Asn Glu Ile Ala 
                85                  90                  95      


Arg Ile Lys Lys Leu Ile Gly Glu Ala Gly Ser Ala Trp Ser His Pro 
            100                 105                 110         


Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Ala 
        115                 120                 125             


Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Cys 
145 


<210>  64
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  64

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Trp Ala Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            20                  25                  30          


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        35                  40                  45              


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    50                  55                  60                  


Glu Lys Thr Arg Arg Gln Leu Arg Glu Met Lys Gln Ile Glu Asp Lys 
65                  70                  75                  80  


Ile Glu Glu Ile Leu Ser Lys Ile Tyr His Ile Glu Asn Glu Ile Ala 
                85                  90                  95      


Arg Ile Lys Lys Leu Ile Gly Glu Ala Gly Ser Ala Trp Ser His Pro 
            100                 105                 110         


Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Ala 
        115                 120                 125             


Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Cys 
145 


<210>  65
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Ala Asp Met Lys Pro Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Pro Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Thr Pro Ile Phe Gly Ser Pro Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Asp Arg Val Ile Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Gly Gly Glu Trp Gly Ser Gly Arg Tyr Tyr Leu Asp His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120         


<210>  66
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  66
gaggtgcagc tggtggagtc tggggctgac atgaagccgc ctgggtcctc ggtgaaagtc       60

ccctgcaagg cttctggaga caccttctcc agctacacta tcacctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcaccccca tctttggttc accaaactac      180

gcacagaggt tccaggacag agtcatcatt accgcggacg aatccactag cacagcctac      240

atggaagtga gcaacctcag atctgaggac acggccgtct atttctgtgc gagggttgga      300

ggtgaatggg gcagtggccg ttactacctt gaccactggg gccagggaac cctggtcacc      360

gtctcc                                                                 366


<210>  67
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  67

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ala Gly Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr 
            100                 105                 110 


<210>  68
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  68
gacatccagt tgacccagtc tccagcctcc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttgcc ggcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcaccag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataatt ggcctccgtg gacgttcggc      300

caagggacca aagtggatat caaacgtacg                                       330


<210>  69
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ile Thr His 
            20                  25                  30          


Val Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Phe Ile Ala Ile Phe Gly Thr Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Ser Gly Ser Tyr Gly Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  70
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  70
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgtaagg cttctggagg caccttcatt acccatgttt ttacttgggt gcgacaggcc      120

cctggacaag ggcttgagtg ggttggaggg ttcatcgcta tctttggcac atcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcagacg agtctacgag cacagcctac      240

atggagctga ccagcctgac atctgaggac acggccgtgt attactgtgc gagaggaatt      300

agtgggagct atgggtggtt tgacccctgg ggccagggaa ccctggtcac cgtctcc         357


<210>  71
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  71

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Arg Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Val Lys Thr Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  72
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  72
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattaga aagtatttga attggtatca gcagaaacca      120

gggaaagccc ctaacctcct gatctacgat gcatccaatg tgaagacagg ggtcccttca      180

aggttccgtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tcccgatcac cttcggccaa      300

gggacacgac tggagattaa acgtacg                                          327


<210>  73
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  73

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Thr Val Ser Gly Gly Ser Ile Thr Arg Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Ser Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser 
        115         


<210>  74
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  74
gaggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

agttgcactg tctctggtgg ctccatcact agaagtagtt actattgggg ctggatccgc      120

cagcccccag ggaaggggct ggaatggatt gggaatatct attatagtgg gaccacgtac      180

tacaatccgt ccctcaagag tcgagtcacc atatccgtgg acacgtctaa gaaccagttc      240

tccctgaagt tgagttctgt gaccgccgca gacacggctg tatattactg tgcgagactc      300

tatgggtcgg ggttagacta ttggggccag ggaaccctgg tcaccgtctc c               351


<210>  75
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  75

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ser Ser Arg Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Leu Ala Ala Ser Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Leu Asn Gly Phe Leu Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  76
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  76
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcagtagt cgttatgtag cctggtatca gcaaaagcca      120

gggaaagccc ctaaactcct gatcttggct gcttccactt tgcatactgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttattc ctgtcaacag cttaatggtt tcctcctcac tttcggcgga      300

gggaccaagg tggaaatcaa acgtacg                                          327


<210>  77
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Asp 
1               5                   10                  15      


Ile Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Glu Ser Arg Leu Gly Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Phe Val Ser Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Val Arg Ser Gly Tyr Pro Asp Thr Ala Tyr Tyr Phe Asp 
            100                 105                 110         


Lys Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120             


<210>  78
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  78
gaggtgcagc tggtggagtc tggcccagga ctggtgaagc cttcggacat cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtaattact actggggctg gattcggcag      120

cccccaggga aggggctgga gtggattggg agtatctatc atagtgggag cacctactac      180

aagccgtctc tcgagagtcg actcggcata tcagtagaca cgtccaagaa ccaattctcc      240

ctgaagttga gttttgtgtc cgccgcagac acggccgtgt actattgtgc gcgacatgtt      300

aggagtggtt accccgatac tgcatactac tttgacaagt ggggccaggg aaccctggtc      360

accgtctcc                                                              369


<210>  79
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ala Trp Ala Leu Leu Leu Leu Gly Leu Leu Ser His Cys Thr Gly 
1               5                   10                  15      


Ser Val Thr Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala 
            20                  25                  30          


Pro Gly Glu Thr Ala Arg Ile Ser Cys Gly Gly Asn Asn Ile Gly Thr 
        35                  40                  45              


Lys Val Leu His Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val 
                85                  90                  95      


Glu Val Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ile Ser 
            100                 105                 110         


Thr Asp Gln Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
        115                 120                 125             


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
145                 150                 155                 160 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
                165                 170                 175     


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
            180                 185                 190         


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
        195                 200                 205             


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
    210                 215                 220                 


Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230             


<210>  80
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  80
atggcctggg ctctgctgct tctcggcctc ctctctcact gcacaggctc tgtgacctcc       60

tatgtgctga ctcagccacc ctcggtgtca gtggccccag gagagacggc caggatttcc      120

tgtgggggaa acaacattgg aactaaagtt ctacactggt accagcagac gccaggccag      180

gcccctgtgc tcgtcgtcta tgatgacagc gaccggccct cagggatccc tgagcgattc      240

tctggctcca actctgggaa cacggccacc ctgaccatca gcagggtcga agtcggggat      300

gaggccgact attactgtca ggtgtgggat atcagtactg atcaagcggt attcggcgga      360

gggaccaaac tgaccgtcct aggtcagccc aaggctgccc cctcggtcac tctgttcccg      420

ccctcctctg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc      480

tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      540

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc      600

ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      660

agcaccgtgg agaagacagt ggcccctaca gaatgttcat ag                         702


<210>  81
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  81

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Trp Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Pro Ile Phe Ser Ser Arg 
            20                  25                  30          


Ser Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Ile Pro Ile Phe Gly Gly Pro Thr Val Pro Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Met Thr Ala Asp Asp Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Tyr Tyr Ser Gly Ser Gly Thr Tyr Ala Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120         


<210>  82
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  82
gaggtgcagc tggtgcagtc tggggctgag tggaagaagc ctggatcctc ggtgagggtc       60

tcctgtaagg cctctggacc catcttcagc agcagatcaa taagttgggt gcggcaggcc      120

ccaggacaag ggcttgagtg gatggggggc gtcatcccta tttttggtgg gccgaccgtc      180

ccccagaagt ttcagggcag actcacaatg accgcggacg actccaccag cacagcctac      240

atggagttga atcgcctgac atctgacgac acggccgtct attactgtgc gaggacggga      300

tattattctg ggtcggggac ttatgccttt gactattggg gccaaggaac cctggtcacc      360

gtctcc                                                                 366


<210>  83
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  83

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Val Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Tyr His Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  84
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  84
gaaatagtga tgacacagtc tccagccacc gtgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc aacaacttag cctggtacca gcagaagcct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg caatttatta ctgtcagcag tatcataact ggcctccgct cactttcggc      300

ggagggacca aggtggaaat caaacgtacg                                       330


<210>  85
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Thr Phe Ser Leu Ile Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Phe Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Ser Tyr Ala Asp Thr Tyr Phe Tyr His Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 


<210>  86
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  86
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgtag cctccacgtt cagccttatt aactattgga tgacctgggt ccgccaggct      120

cctgggaagg ggctggagtg ggtggccaac ataaagcagg atggatttga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ttcactgtat      240

ctgcaaatga acagcctgag agtcgaggac acggctgtgt attactgtgc gagacaggga      300

tcctacgctg acacgtactt ctaccactac ggtatggacg tctggggcca agggaccacg      360

gtcaccgtct cc                                                          372


<210>  87
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ala Trp Met Met Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Asp Ala Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Gly Asn Ser Asn Arg Leu Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr 
            100                 105                 110         


Asp Ser Ser Leu Ser Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  88
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  88
atggcctgga tgatgcttct cctcactctc ctcgctcact gcacagggtc ctgggcccag       60

tctgcgctga cgcagccgcc ctcagtgtct ggggccccag ggcagagggt caccatctcc      120

tgcactggga gcagctccaa catcggggca ggttatgatg catactggta ccagcaactt      180

ccaggaacag cccccaaact cctcatctac ggtaacagca atcgactctc aggggtccct      240

gaccgattct ctgcctccaa gtctggcacc tcagcctccc tggccatcac tgggctccag      300

gctgaggatg aggctgatta ttactgccag tcctatgaca gcagcctgtc gattttcggc      360

ggagggacca agctgaccgt cctacgtcag cccaaggctg ccccctcggt cactctgttc      420

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      480

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      540

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctacctg      600

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      660

gggagcaccg tggagaagac agtggcccct acagaatgtt catag                      705


<210>  89
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Phe Phe Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ala Pro Tyr Asp Thr Tyr Tyr Tyr Tyr Tyr Ala Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 


<210>  90
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  90
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttaat agctattgga tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaattcttt      180

gtagactctg tgaagggccg attcaccatc tccagagaca acgccaagac ctcactgtat      240

ctgcaaatga acagcctgag agtcgaggac acggctgtgt attactgtgc gagagagggg      300

gccccctatg atacatacta ctactactac gctatggacg tctggggcca agggaccacg      360

gtcaccgtct cc                                                          372


<210>  91
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Gly Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala 
    50                  55                  60                  


Pro Lys Leu Leu Val Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr 
            100                 105                 110         


Asp Ile Ser Leu Ser Gly Ser Asn Val Phe Gly Thr Gly Thr Lys Val 
        115                 120                 125             


Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     


Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
            180                 185                 190         


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         


<210>  92
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  92
atggcctggg ctctgctact cctcactctc ctcgctcact gcacagggtc ctgggcccag       60

tctgtgctga cgcagccgcc ctcagtgtct ggggccccag ggcagagggt caccatctcc      120

tgcactggga ccagctccaa catcggggca ggttatggtg tacactggta ccagcagctt      180

ccaggagcag cccccaaact cctcgtctat ggtaacagca atcggccctc aggggtccct      240

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcac tgggctccag      300

gctgaggatg aggctgatta ttactgccag tcgtatgaca tcagcctgag tggttcgaat      360

gtcttcggaa ctgggaccaa ggtcaccgtc ctaggtcagc ccaaggccaa ccccactgtc      420

actctgttcc cgccctcctc tgaggagctc caagccaaca aggccacact agtgtgtctg      480

atcagtgact tctacccggg agctgtgaca gtggcctgga aggcagatgg cagccccgtc      540

aaggcgggag tggagaccac caaaccctcc aaacagagca acaacaagta cgcggccagc      600

agctacctga gcctgacgcc cgagcagtgg aagtcccaca gaagctacag ctgccaggtc      660

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            714


<210>  93
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Tyr Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Ser Tyr Leu Asp Thr Tyr Tyr Tyr His Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 


<210>  94
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  94
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggatt cagctttagt agctattgga tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttgccaac ataaagcaat atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactttat      240

ctacaaatga acagcctaag agacgacgac acggccgttt attactgtgc gagaatgggg      300

agttatctag atacttacta ctaccactac ggtatggacg tctggggcca agggaccacg      360

gtcaccgtct cc                                                          372


<210>  95
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ala Trp Met Met Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Leu Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Asp Tyr Asp Val Tyr Trp Tyr Gln His Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Met Tyr Gly Asp Gly Tyr Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr 
            100                 105                 110         


Asp Ser Ser Leu Ser Arg Arg Val Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Met Cys Leu 
145                 150                 155                 160 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         


<210>  96
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  96
atggcctgga tgatgcttct cctcactctc ctcgctcact gcacagggtc ctgggcccag       60

tctgtgctga cgcagccgcc ctcactgtct ggggccccag ggcagagggt caccatctcc      120

tgcacgggga gcagctccaa catcggggca gattatgatg tatattggta tcagcacctt      180

ccaggaacag cccccaaact cctcatgtat ggtgacggct atcggccctc aggggtccct      240

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcac tgggctccag      300

gctgaggatg aggctgatta ttactgccag tcctatgaca gcagtctgag tcgtcgtgtg      360

gtattcggcg gagggaccaa gctgaccgtc cttggtcagc ccaaggctgc cccctcggtc      420

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact gatgtgtctc      480

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      540

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      600

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      660

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc atag            714


<210>  97
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Asn Phe Lys Ser Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Asn Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu His 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Ser Ser Trp Asp Thr Tyr Tyr Tyr Tyr Tyr Ala Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 


<210>  98
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  98
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctacgactc       60

tcctgtgcag cctctgaatt caactttaag agttattgga tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaaaactat      180

gtggactctg tgaagggccg attcaccatc tccagagata atgccaagaa ctcgctgcat      240

ctgcaaatga gcagcctgag agtcgacgac acggctgtat attactgtgc gcgaacgggc      300

agcagttggg acacatacta ctactactac gctatggacg tctggggcca agggaccacg      360

gtcaccgtct cc                                                          372


<210>  99
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  99

Asp Ile Gln Leu Thr Gln Ser Pro Val Ser Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Arg Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105         


<210>  100
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  100
gacatccagt tgacccagtc tccagtctcc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tggtctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggcccc tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cgcgaagatt ttgcagtgta ttattgtcag cagtatggta ggtcttttgg ccaggggacc      300

aaggtggaga tcaaacgtac g                                                321


<210>  101
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Glu Ser Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Asn Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Ser Asn Trp Asp Thr Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 


<210>  102
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  102
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt catttttgaa agttactgga tgacctgggt ccgccaggct      120

ccagggaagg ggctggaatg ggtggccaac ataaagcaag atggaagtga gaaaaactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagac ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccatgt attactgtgc gagatcgggc      300

agcaactggg acacatatta ctactactac ggtatggacg tctggggcca agggaccacg      360

gtcaccgtct cc                                                          372


<210>  103
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  103

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Ser Asn 
            20                  25                  30          


Tyr Leu Gly Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105         


<210>  104
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  104
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttgac agcaactact taggctggta ccagcagaga      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcgtccca      180

gacaggttca gtgccagtgg gtctgggaca gacttcactc tcagcattag cagactggag      240

cctgaagatt ttgcagtgta ctactgtcag cagtatggta gctcttttgg ccaggggacc      300

aaggtggaaa tcaaacgtac g                                                321


<210>  105
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  105
ccatcagctg gggggtccct gagactctcc tg                                     32


<210>  106
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  106
cgctcagctt acctgaggag acggtgacc                                         29


<210>  107
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  107
cgtatcgcct ccctcgcgcc atcagctggg gggtccctga gactctcctg                  50


<210>  108
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  108
ctatgcgcct tgccagcccg ctcagcttac ctgaggagac ggtgacc                     47


<210>  109
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  109

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


