                               SEQUENCE LISTING	

<110> CHINA AGRICULTURAL UNIVERSITY
 
<120> COMBINED ANTIGEN AND DNA VACCINE FOR PREVENTING AND TREATING 
      AUTOIMMUNE DISEASES

<130> P53132WO/TCL

<140>
<141>

<150> 61/466,741
<151> 2011-03-23

<150> 61/386,839
<151> 2010-09-27

<160> 192   

<170> PatentIn version 3.5

<210> 1
<211> 15
<212> PRT
<213> Pulex irritans

<400> 1
Gln Glu Lys Glu Lys Cys Met Lys Phe Cys Lys Lys Val Cys Lys 
1               5                   10                  15  


<210> 2
<211> 14
<212> PRT
<213> Pulex irritans

<400> 2
Pro Asp Trp Lys Val Ser Lys Glu Cys Lys Asp Pro Asn Asn 
1               5                   10                  


<210> 3
<211> 320
<212> PRT
<213> Dermatophagoides pternyssinus

<400> 3
Met Lys Ile Val Leu Ala Ile Ala Ser Leu Leu Ala Leu Ser Ala Val 
1               5                   10                  15      


Tyr Ala Arg Pro Ser Ser Ile Lys Thr Phe Glu Glu Tyr Lys Lys Ala 
            20                  25                  30          


Phe Asn Lys Ser Tyr Ala Thr Phe Glu Asp Glu Glu Ala Ala Arg Lys 
        35                  40                  45              


Asn Phe Leu Glu Ser Val Lys Tyr Val Gln Ser Asn Gly Gly Ala Ile 
    50                  55                  60                  


Asn His Leu Ser Asp Leu Ser Leu Asp Glu Phe Lys Asn Arg Phe Leu 
65                  70                  75                  80  


Met Ser Ala Glu Ala Phe Glu His Leu Lys Thr Gln Phe Asp Leu Asn 
                85                  90                  95      


Ala Glu Thr Asn Ala Cys Ser Ile Asn Gly Asn Ala Pro Ala Glu Ile 
            100                 105                 110         


Asp Leu Arg Gln Met Arg Thr Val Thr Pro Ile Arg Met Gln Gly Gly 
        115                 120                 125             


Cys Gly Ser Cys Trp Ala Phe Ser Gly Val Ala Ala Thr Glu Ser Ala 
    130                 135                 140                 


Tyr Leu Ala Tyr Arg Asn Gln Ser Leu Asp Leu Ala Glu Gln Glu Leu 
145                 150                 155                 160 


Val Asp Cys Ala Ser Gln His Gly Cys His Gly Asp Thr Ile Pro Arg 
                165                 170                 175     


Gly Ile Glu Tyr Ile Gln His Asn Gly Val Val Gln Glu Ser Tyr Tyr 
            180                 185                 190         


Arg Tyr Val Ala Arg Glu Gln Ser Cys Arg Arg Pro Asn Ala Gln Arg 
        195                 200                 205             


Phe Gly Ile Ser Asn Tyr Cys Gln Ile Tyr Pro Pro Asn Val Asn Lys 
    210                 215                 220                 


Ile Arg Glu Ala Leu Ala Gln Thr His Ser Ala Ile Ala Val Ile Ile 
225                 230                 235                 240 


Gly Ile Lys Asp Leu Asp Ala Phe Arg His Tyr Asp Gly Arg Thr Ile 
                245                 250                 255     


Ile Gln Arg Asp Asn Gly Tyr Gln Pro Asn Tyr His Ala Val Asn Ile 
            260                 265                 270         


Val Gly Tyr Ser Asn Ala Gln Gly Val Asp Tyr Trp Ile Val Arg Asn 
        275                 280                 285             


Ser Trp Asp Thr Asn Trp Gly Asp Asn Gly Tyr Gly Tyr Phe Ala Ala 
    290                 295                 300                 


Asn Ile Asp Leu Met Met Ile Glu Glu Tyr Pro Tyr Val Val Ile Leu 
305                 310                 315                 320 


<210> 4
<211> 110
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210> 5
<211> 11
<212> PRT
<213> Homo sapiens

<400> 5
Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala 
1               5                   10      


<210> 6
<211> 9
<212> PRT
<213> Homo sapiens

<400> 6
Leu Tyr Leu Val Cys Gly Glu Arg Gly 
1               5                   


<210> 7
<211> 15
<212> PRT
<213> Homo sapiens

<400> 7
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
1               5                   10                  15  


<210> 8
<211> 13
<212> PRT
<213> Homo sapiens

<400> 8
Gln His Leu Gln Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe 
1               5                   10              


<210> 9
<211> 13
<212> PRT
<213> Homo sapiens

<400> 9
Tyr Thr Phe Leu Asn Phe Met Ser Asn Val Gly Asp Pro 
1               5                   10              


<210> 10
<211> 13
<212> PRT
<213> Homo sapiens

<400> 10
Arg Val Leu Asn Ile Asp Leu Leu Trp Ser Val Pro Ile 
1               5                   10              


<210> 11
<211> 13
<212> PRT
<213> Homo sapiens

<400> 11
Asp Trp Ile His Ile Asp Thr Thr Pro Phe Ala Gly Leu 
1               5                   10              


<210> 12
<211> 13
<212> PRT
<213> Homo sapiens

<400> 12
Lys Gly Leu Gly Val Asp Leu Leu Trp Thr Leu Glu Lys 
1               5                   10              


<210> 13
<211> 13
<212> PRT
<213> Homo sapiens

<400> 13
Glu Trp Val His Ile Asp Thr Thr Pro Phe Ala Ser Leu 
1               5                   10              


<210> 14
<211> 13
<212> PRT
<213> Homo sapiens

<400> 14
Phe Thr Leu Gly Leu Asp Leu Ser Trp Ser Ile Ser Leu 
1               5                   10              


<210> 15
<211> 13
<212> PRT
<213> Homo sapiens

<400> 15
Glu Trp Ile His Val Asp Ser Arg Pro Phe Ala Ser Leu 
1               5                   10              


<210> 16
<211> 247
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Val Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Phe 
                245         


<210> 17
<211> 22
<212> PRT
<213> Homo sapiens

<400> 17
Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu 
            20          


<210> 18
<211> 23
<212> PRT
<213> Homo sapiens

<400> 18
Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu Val 
1               5                   10                  15      


Glu Leu Pro Cys Arg Ile Ser 
            20              


<210> 19
<211> 33
<212> PRT
<213> Homo sapiens

<400> 19
Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg 
            20                  25                  30          


Gly 
    


<210> 20
<211> 197
<212> PRT
<213> Homo sapiens

<400> 20
Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly 
    130                 135                 140                 


Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp 
145                 150                 155                 160 


Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 
                165                 170                 175     


Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser 
            180                 185                 190         


Pro Met Ala Arg Arg 
        195         


<210> 21
<211> 23
<212> PRT
<213> Homo sapiens

<400> 21
Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu Cys 
1               5                   10                  15      


Asn Met Tyr Lys Asp Ser His 
            20              


<210> 22
<211> 15
<212> PRT
<213> Homo sapiens

<400> 22
Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu 
1               5                   10                  15  


<210> 23
<211> 20
<212> PRT
<213> Homo sapiens

<400> 23
Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 
1               5                   10                  15      


Lys Ser His Gly 
            20  


<210> 24
<211> 26
<212> PRT
<213> Homo sapiens

<400> 24
Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala 
1               5                   10                  15      


Ser Asp Tyr Lys Ser Ala His Lys Gly Phe 
            20                  25      


<210> 25
<211> 15
<212> PRT
<213> Homo sapiens

<400> 25
Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly 
1               5                   10                  15  


<210> 26
<211> 12
<212> PRT
<213> Homo sapiens

<400> 26
Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
1               5                   10          


<210> 27
<211> 274
<212> PRT
<213> Homo sapiens

<400> 27
Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Ile Thr Tyr Ala Leu Thr Val Val Trp 
145                 150                 155                 160 


Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn 
                165                 170                 175     


Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala 
            180                 185                 190         


Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro 
        195                 200                 205             


Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser Ile 
    210                 215                 220                 


Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe Ile Ala Ala 
225                 230                 235                 240 


Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr Phe Met Ile 
                245                 250                 255     


Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg Gly Thr 
            260                 265                 270         


Lys Phe 
        


<210> 28
<211> 19
<212> PRT
<213> Homo sapiens

<400> 28
Leu Phe Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu 
1               5                   10                  15      


Ile Glu Thr 
            


<210> 29
<211> 11
<212> PRT
<213> Homo sapiens

<400> 29
Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala 
1               5                   10                  


<210> 30
<211> 21
<212> PRT
<213> Homo sapiens

<400> 30
Leu Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr 
1               5                   10                  15      


Gln Asp Tyr Glu Tyr 
            20      


<210> 31
<211> 20
<212> PRT
<213> Homo sapiens

<400> 31
Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly 
1               5                   10                  15      


Ser Leu Cys Ala 
            20  


<210> 32
<211> 16
<212> PRT
<213> Homo sapiens

<400> 32
Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala 
1               5                   10                  15      


<210> 33
<211> 20
<212> PRT
<213> Homo sapiens

<400> 33
Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
1               5                   10                  15      


Val Leu Pro Trp 
            20  


<210> 34
<211> 81
<212> PRT
<213> Homo sapiens

<400> 34
Met Ser Gln Lys Pro Ala Lys Glu Gly Pro Arg Leu Ser Lys Asn Gln 
1               5                   10                  15      


Lys Tyr Ser Glu His Phe Ser Ile His Cys Cys Pro Pro Phe Thr Phe 
            20                  25                  30          


Leu Asn Ser Lys Lys Glu Ile Val Asp Arg Lys Tyr Ser Ile Cys Lys 
        35                  40                  45              


Ser Gly Cys Phe Tyr Gln Lys Lys Glu Glu Asp Trp Ile Cys Cys Ala 
    50                  55                  60                  


Cys Gln Lys Thr Arg Leu Lys Arg Lys Ile Arg Pro Thr Pro Lys Lys 
65                  70                  75                  80  


Lys 
    


<210> 35
<211> 218
<212> PRT
<213> Homo sapiens

<400> 35
Met Val Ala Thr Cys Leu Gln Val Val Gly Phe Val Thr Ser Phe Val 
1               5                   10                  15      


Gly Trp Ile Gly Val Ile Val Thr Thr Ser Thr Asn Asp Trp Val Val 
            20                  25                  30          


Thr Cys Gly Tyr Thr Ile Pro Thr Cys Arg Lys Leu Asp Glu Leu Gly 
        35                  40                  45              


Ser Lys Gly Leu Trp Ala Asp Cys Val Met Ala Thr Gly Leu Tyr His 
    50                  55                  60                  


Cys Lys Pro Leu Val Asp Ile Leu Ile Leu Pro Gly Tyr Val Gln Ala 
65                  70                  75                  80  


Cys Arg Ala Leu Met Ile Ala Ala Ser Val Leu Gly Leu Pro Ala Ile 
                85                  90                  95      


Leu Leu Leu Leu Thr Val Leu Pro Cys Ile Arg Met Gly Gln Glu Pro 
            100                 105                 110         


Gly Val Ala Lys Tyr Arg Arg Ala Gln Leu Ala Gly Val Leu Leu Ile 
        115                 120                 125             


Leu Leu Ala Leu Cys Ala Leu Val Ala Thr Ile Trp Phe Pro Val Cys 
    130                 135                 140                 


Ala His Arg Glu Thr Thr Ile Val Ser Phe Gly Tyr Ser Leu Tyr Ala 
145                 150                 155                 160 


Gly Trp Ile Gly Ala Val Leu Cys Leu Val Gly Gly Cys Val Ile Leu 
                165                 170                 175     


Cys Cys Ala Gly Asp Ala Gln Ala Phe Gly Glu Asn Val Ser Thr Thr 
            180                 185                 190         


Leu Arg Ala Leu Ala Pro Arg Leu Met Arg Arg Val Pro Thr Tyr Lys 
        195                 200                 205             


Arg Ala Ala Arg Leu Pro Thr Glu Val Leu 
    210                 215             


<210> 36
<211> 14
<212> PRT
<213> Homo sapiens

<400> 36
His Pro Ile Arg Ala Leu Val Gly Asp Glu Val Glu Leu Pro 
1               5                   10                  


<210> 37
<211> 20
<212> PRT
<213> Homo sapiens

<400> 37
Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr Arg 
1               5                   10                  15      


Asn Gly Lys Asp 
            20  


<210> 38
<211> 26
<212> PRT
<213> Homo sapiens

<400> 38
Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val 
1               5                   10                  15      


Leu Leu Ala Val Leu Pro Val Leu Leu Leu 
            20                  25      


<210> 39
<211> 638
<212> PRT
<213> Homo sapiens

<400> 39
Met Ala Gly Gly Ser Ala Thr Thr Trp Gly Tyr Pro Val Ala Leu Leu 
1               5                   10                  15      


Leu Leu Val Ala Thr Leu Gly Leu Gly Arg Trp Leu Gln Pro Asp Pro 
            20                  25                  30          


Gly Leu Pro Gly Leu Arg His Ser Tyr Asp Cys Gly Ile Lys Gly Met 
        35                  40                  45              


Gln Leu Leu Val Phe Pro Arg Pro Gly Gln Thr Leu Arg Phe Lys Val 
    50                  55                  60                  


Val Asp Glu Phe Gly Asn Arg Phe Asp Val Asn Asn Cys Ser Ile Cys 
65                  70                  75                  80  


Tyr His Trp Val Thr Ser Arg Pro Gln Glu Pro Ala Val Phe Ser Ala 
                85                  90                  95      


Asp Tyr Arg Gly Cys His Val Leu Glu Lys Asp Gly Arg Phe His Leu 
            100                 105                 110         


Arg Val Phe Met Glu Ala Val Leu Pro Asn Gly Arg Val Asp Val Ala 
        115                 120                 125             


Gln Asp Ala Thr Leu Ile Cys Pro Lys Pro Asp Pro Ser Arg Thr Leu 
    130                 135                 140                 


Asp Ser Gln Leu Ala Pro Pro Ala Met Phe Ser Val Ser Thr Pro Gln 
145                 150                 155                 160 


Thr Leu Ser Phe Leu Pro Thr Ser Gly His Thr Ser Gln Gly Ser Gly 
                165                 170                 175     


His Ala Phe Pro Ser Pro Leu Asp Pro Gly His Ser Ser Val His Pro 
            180                 185                 190         


Thr Pro Ala Leu Pro Ser Pro Gly Pro Gly Pro Thr Leu Ala Thr Leu 
        195                 200                 205             


Ala Gln Pro His Trp Gly Thr Leu Glu His Trp Asp Val Asn Lys Arg 
    210                 215                 220                 


Asp Tyr Ile Gly Thr His Leu Ser Gln Glu Gln Cys Gln Val Ala Ser 
225                 230                 235                 240 


Gly His Leu Pro Cys Ile Val Arg Arg Thr Ser Lys Glu Ala Cys Gln 
                245                 250                 255     


Gln Ala Gly Cys Cys Tyr Asp Asn Thr Arg Glu Val Pro Cys Tyr Tyr 
            260                 265                 270         


Gly Asn Thr Ala Thr Val Gln Cys Phe Arg Asp Gly Tyr Phe Val Leu 
        275                 280                 285             


Val Val Ser Gln Glu Met Ala Leu Thr His Arg Ile Thr Leu Ala Asn 
    290                 295                 300                 


Ile His Leu Ala Tyr Ala Pro Thr Ser Cys Ser Pro Thr Gln His Thr 
305                 310                 315                 320 


Glu Ala Phe Val Val Phe Tyr Phe Pro Leu Thr His Cys Gly Thr Thr 
                325                 330                 335     


Met Gln Val Ala Gly Asp Gln Leu Ile Tyr Glu Asn Trp Leu Val Ser 
            340                 345                 350         


Gly Ile His Ile Gln Lys Gly Pro Gln Gly Ser Ile Thr Arg Asp Ser 
        355                 360                 365             


Thr Phe Gln Leu His Val Arg Cys Val Phe Asn Ala Ser Asp Phe Leu 
    370                 375                 380                 


Pro Ile Gln Ala Ser Ile Phe Pro Pro Pro Ser Pro Ala Pro Met Thr 
385                 390                 395                 400 


Gln Pro Gly Pro Leu Arg Leu Glu Leu Arg Ile Ala Lys Asp Glu Thr 
                405                 410                 415     


Phe Ser Ser Tyr Tyr Gly Glu Asp Asp Tyr Pro Ile Val Arg Leu Leu 
            420                 425                 430         


Arg Glu Pro Val His Val Glu Val Arg Leu Leu Gln Arg Thr Asp Pro 
        435                 440                 445             


Asn Leu Val Leu Leu Leu His Gln Cys Trp Gly Ala Pro Ser Ala Asn 
    450                 455                 460                 


Pro Phe Gln Gln Pro Gln Trp Pro Ile Leu Ser Asp Gly Cys Pro Phe 
465                 470                 475                 480 


Lys Gly Asp Ser Tyr Arg Thr Gln Met Val Ala Leu Asp Gly Ala Thr 
                485                 490                 495     


Pro Phe Gln Ser His Tyr Gln Arg Phe Thr Val Ala Thr Phe Ala Leu 
            500                 505                 510         


Leu Asp Ser Gly Ser Gln Arg Ala Leu Arg Gly Leu Val Tyr Leu Phe 
        515                 520                 525             


Cys Ser Thr Ser Ala Cys His Thr Ser Gly Leu Glu Thr Cys Ser Thr 
    530                 535                 540                 


Ala Cys Ser Thr Gly Thr Thr Arg Gln Arg Arg Ser Ser Gly His Arg 
545                 550                 555                 560 


Asn Asp Thr Ala Arg Pro Gln Asp Ile Val Ser Ser Pro Gly Pro Val 
                565                 570                 575     


Gly Phe Glu Asp Ser Tyr Gly Gln Glu Pro Thr Leu Gly Pro Thr Asp 
            580                 585                 590         


Ser Asn Gly Asn Ser Ser Leu Arg Pro Leu Leu Trp Ala Val Leu Leu 
        595                 600                 605             


Leu Pro Ala Val Ala Leu Val Leu Gly Phe Gly Val Phe Val Gly Leu 
    610                 615                 620                 


Ser Gln Thr Trp Ala Gln Lys Leu Trp Glu Ser Asn Arg Gln 
625                 630                 635             


<210> 40
<211> 745
<212> PRT
<213> Homo sapiens

<400> 40
Met Ala Cys Arg Gln Arg Gly Gly Ser Trp Ser Pro Ser Gly Trp Phe 
1               5                   10                  15      


Asn Ala Gly Trp Ser Thr Tyr Arg Ser Ile Ser Leu Phe Phe Ala Leu 
            20                  25                  30          


Val Thr Ser Gly Asn Ser Ile Asp Val Ser Gln Leu Val Asn Pro Ala 
        35                  40                  45              


Phe Pro Gly Thr Val Thr Cys Asp Glu Arg Glu Ile Thr Val Glu Phe 
    50                  55                  60                  


Pro Ser Ser Pro Gly Thr Lys Lys Trp His Ala Ser Val Val Asp Pro 
65                  70                  75                  80  


Leu Gly Leu Asp Met Pro Asn Cys Thr Tyr Ile Leu Asp Pro Glu Lys 
                85                  90                  95      


Leu Thr Leu Arg Ala Thr Tyr Asp Asn Cys Thr Arg Arg Val His Gly 
            100                 105                 110         


Gly His Gln Met Thr Ile Arg Val Met Asn Asn Ser Ala Ala Leu Arg 
        115                 120                 125             


His Gly Ala Val Met Tyr Gln Phe Phe Cys Pro Ala Met Gln Val Glu 
    130                 135                 140                 


Glu Thr Gln Gly Leu Ser Ala Ser Thr Ile Cys Gln Lys Asp Phe Met 
145                 150                 155                 160 


Ser Phe Ser Leu Pro Arg Val Phe Ser Gly Leu Ala Asp Asp Ser Lys 
                165                 170                 175     


Gly Thr Lys Val Gln Met Gly Trp Ser Ile Glu Val Gly Asp Gly Ala 
            180                 185                 190         


Arg Ala Lys Thr Leu Thr Leu Pro Glu Ala Met Lys Glu Gly Phe Ser 
        195                 200                 205             


Leu Leu Ile Asp Asn His Arg Met Thr Phe His Val Pro Phe Asn Ala 
    210                 215                 220                 


Thr Gly Val Thr His Tyr Val Gln Gly Asn Ser His Leu Tyr Met Val 
225                 230                 235                 240 


Ser Leu Lys Leu Thr Phe Ile Ser Pro Gly Gln Lys Val Ile Phe Ser 
                245                 250                 255     


Ser Gln Ala Ile Cys Ala Pro Asp Pro Val Thr Cys Asn Ala Thr His 
            260                 265                 270         


Met Thr Leu Thr Ile Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Ser 
        275                 280                 285             


Phe Glu Asn Gln Asn Ile Asp Val Ser Gln Leu His Asp Asn Gly Ile 
    290                 295                 300                 


Asp Leu Glu Ala Thr Asn Gly Met Lys Leu His Phe Ser Lys Thr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Lys Cys Leu Leu His Gln Phe Tyr Leu 
                325                 330                 335     


Ala Ser Leu Lys Leu Thr Phe Leu Leu Arg Pro Glu Thr Val Ser Met 
            340                 345                 350         


Val Ile Tyr Pro Glu Cys Leu Cys Glu Ser Pro Val Ser Ile Val Thr 
        355                 360                 365             


Gly Glu Leu Cys Thr Gln Asp Gly Phe Met Asp Val Glu Val Tyr Ser 
    370                 375                 380                 


Tyr Gln Thr Gln Pro Ala Leu Asp Leu Gly Thr Leu Arg Val Gly Asn 
385                 390                 395                 400 


Ser Ser Cys Gln Pro Val Phe Glu Ala Gln Ser Gln Gly Leu Val Arg 
                405                 410                 415     


Phe His Ile Pro Leu Asn Gly Cys Gly Thr Arg Tyr Lys Phe Glu Asp 
            420                 425                 430         


Asp Lys Val Val Tyr Glu Asn Glu Ile His Ala Leu Trp Thr Asp Phe 
        435                 440                 445             


Pro Pro Ser Lys Ile Ser Arg Asp Ser Glu Phe Arg Met Thr Val Lys 
    450                 455                 460                 


Cys Ser Tyr Ser Arg Asn Asp Met Leu Leu Asn Ile Asn Val Glu Ser 
465                 470                 475                 480 


Leu Thr Pro Pro Val Ala Ser Val Lys Leu Gly Pro Phe Thr Leu Ile 
                485                 490                 495     


Leu Gln Ser Tyr Pro Asp Asn Ser Tyr Gln Gln Pro Tyr Gly Glu Asn 
            500                 505                 510         


Glu Tyr Pro Leu Val Arg Phe Leu Arg Gln Pro Ile Tyr Met Glu Val 
        515                 520                 525             


Arg Val Leu Asn Arg Asp Asp Pro Asn Ile Lys Leu Val Leu Asp Asp 
    530                 535                 540                 


Cys Trp Ala Thr Ser Thr Met Asp Pro Asp Ser Phe Pro Gln Trp Asn 
545                 550                 555                 560 


Val Val Val Asp Gly Cys Ala Tyr Asp Leu Asp Asn Tyr Gln Thr Thr 
                565                 570                 575     


Phe His Pro Val Gly Ser Ser Val Thr His Pro Asp His Tyr Gln Arg 
            580                 585                 590         


Phe Asp Met Lys Ala Phe Ala Phe Val Ser Glu Ala His Val Leu Ser 
        595                 600                 605             


Ser Leu Val Tyr Phe His Cys Ser Ala Leu Ile Cys Asn Arg Leu Ser 
    610                 615                 620                 


Pro Asp Ser Pro Leu Cys Ser Val Thr Cys Pro Val Ser Ser Arg His 
625                 630                 635                 640 


Arg Arg Ala Thr Gly Ala Thr Glu Ala Glu Lys Met Thr Val Ser Leu 
                645                 650                 655     


Pro Gly Pro Ile Leu Leu Leu Ser Asp Asp Ser Ser Phe Arg Gly Val 
            660                 665                 670         


Gly Ser Ser Asp Leu Lys Ala Ser Gly Ser Ser Gly Glu Lys Ser Arg 
        675                 680                 685             


Ser Glu Thr Gly Glu Glu Val Gly Ser Arg Gly Ala Met Asp Thr Lys 
    690                 695                 700                 


Gly His Lys Thr Ala Gly Asp Val Gly Ser Lys Ala Val Ala Ala Val 
705                 710                 715                 720 


Ala Ala Phe Ala Gly Val Val Ala Thr Leu Gly Phe Ile Tyr Tyr Leu 
                725                 730                 735     


Tyr Glu Lys Arg Thr Val Ser Asn His 
            740                 745 


<210> 41
<211> 373
<212> PRT
<213> Homo sapiens

<400> 41
Met Val Met Val Ser Lys Asp Leu Phe Gly Thr Gly Lys Leu Ile Arg 
1               5                   10                  15      


Ala Ala Asp Leu Thr Leu Gly Pro Glu Ala Cys Glu Pro Leu Val Ser 
            20                  25                  30          


Met Asp Thr Glu Asp Val Val Arg Phe Glu Val Gly Leu His Glu Cys 
        35                  40                  45              


Gly Asn Ser Met Gln Val Thr Asp Asp Ala Leu Val Tyr Ser Thr Phe 
    50                  55                  60                  


Leu Leu His Asp Pro Arg Pro Val Gly Asn Leu Ser Ile Val Arg Thr 
65                  70                  75                  80  


Asn Arg Ala Glu Ile Pro Ile Glu Cys Arg Tyr Pro Arg Gln Gly Asn 
                85                  90                  95      


Val Ser Ser Gln Ala Ile Leu Pro Thr Trp Leu Pro Phe Arg Thr Thr 
            100                 105                 110         


Val Phe Ser Glu Glu Lys Leu Thr Phe Ser Leu Arg Leu Met Glu Glu 
        115                 120                 125             


Asn Trp Asn Ala Glu Lys Arg Ser Pro Thr Phe His Leu Gly Asp Ala 
    130                 135                 140                 


Ala His Leu Gln Ala Glu Ile His Thr Gly Ser His Val Pro Leu Arg 
145                 150                 155                 160 


Leu Phe Val Asp His Cys Val Ala Thr Pro Thr Pro Asp Gln Asn Ala 
                165                 170                 175     


Ser Pro Tyr His Thr Ile Val Asp Phe His Gly Cys Leu Val Asp Gly 
            180                 185                 190         


Leu Thr Asp Ala Ser Ser Ala Phe Lys Val Pro Arg Pro Gly Pro Asp 
        195                 200                 205             


Thr Leu Gln Phe Thr Val Asp Val Phe His Phe Ala Asn Asp Ser Arg 
    210                 215                 220                 


Asn Met Ile Tyr Ile Thr Cys His Leu Lys Val Thr Leu Ala Glu Gln 
225                 230                 235                 240 


Asp Pro Asp Glu Leu Asn Lys Ala Cys Ser Phe Ser Lys Pro Ser Asn 
                245                 250                 255     


Ser Trp Phe Pro Val Glu Gly Ser Ala Asp Ile Cys Gln Cys Cys Asn 
            260                 265                 270         


Lys Gly Asp Cys Gly Thr Pro Ser His Ser Arg Arg Gln Pro His Val 
        275                 280                 285             


Met Ser Gln Trp Ser Arg Ser Ala Ser Arg Asn Arg Arg His Val Thr 
    290                 295                 300                 


Glu Glu Ala Asp Val Thr Val Gly Pro Leu Ile Phe Leu Asp Arg Arg 
305                 310                 315                 320 


Gly Asp His Glu Val Glu Gln Trp Ala Leu Pro Ser Asp Thr Ser Val 
                325                 330                 335     


Val Leu Leu Gly Val Gly Leu Ala Val Val Val Ser Leu Thr Leu Thr 
            340                 345                 350         


Ala Val Ile Leu Val Leu Thr Arg Arg Cys Arg Thr Ala Ser His Pro 
        355                 360                 365             


Val Ser Ala Ser Glu 
    370             


<210> 42
<211> 13
<212> PRT
<213> Homo sapiens

<400> 42
Asn Ser Ser Ser Ser Gln Phe Gln Ile His Gly Pro Arg 
1               5                   10              


<210> 43
<211> 8
<212> PRT
<213> Homo sapiens

<400> 43
Gln Phe Gln Ile His Gly Pro Arg 
1               5               


<210> 44
<211> 11
<212> PRT
<213> Homo sapiens

<400> 44
Asn Ser Ser Ser Ser Gln Phe Gln Ile His Gly 
1               5                   10      


<210> 45
<211> 1937
<212> PRT
<213> Homo sapiens

<400> 45
Met Ser Ala Ser Ser Asp Ala Glu Met Ala Val Phe Gly Glu Arg Ala 
1               5                   10                  15      


Pro Tyr Leu Arg Lys Ser Glu Lys Glu Arg Ile Glu Ala Gln Asn Lys 
            20                  25                  30          


Pro Phe Asp Ala Lys Thr Ser Val Phe Val Ala Glu Pro Lys Glu Ser 
        35                  40                  45              


Tyr Val Lys Ser Thr Ile Gln Ser Lys Glu Gly Gly Lys Val Thr Val 
    50                  55                  60                  


Lys Thr Glu Gly Gly Ala Thr Leu Thr Val Arg Glu Asp Gln Val Phe 
65                  70                  75                  80  


Pro Met Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met 
                85                  90                  95      


Thr His Leu His Glu Pro Gly Val Leu Tyr Asn Leu Lys Glu Arg Tyr 
            100                 105                 110         


Ala Ala Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val 
        115                 120                 125             


Asn Pro Tyr Lys Trp Leu Pro Val Tyr Lys Pro Glu Val Val Ala Ala 
    130                 135                 140                 


Tyr Arg Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile 
145                 150                 155                 160 


Ser Asp Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser 
                165                 170                 175     


Ile Leu Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys 
            180                 185                 190         


Arg Val Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys 
        195                 200                 205             


Lys Asp Glu Ser Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile 
    210                 215                 220                 


Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg 
225                 230                 235                 240 


Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly 
                245                 250                 255     


Thr Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu 
            260                 265                 270         


Lys Ser Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile 
        275                 280                 285             


Phe Tyr Gln Ile Thr Ser Asn Lys Lys Pro Asp Leu Ile Glu Met Leu 
    290                 295                 300                 


Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Glu 
305                 310                 315                 320 


Ile Thr Val Pro Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp 
                325                 330                 335     


Ser Ala Ile Asp Ile Leu Gly Phe Thr Pro Glu Glu Lys Val Ser Ile 
            340                 345                 350         


Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys 
        355                 360                 365             


Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala 
    370                 375                 380                 


Asp Lys Ala Ala Tyr Leu Gln Ser Leu Asn Ser Ala Asp Leu Leu Lys 
385                 390                 395                 400 


Ala Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys 
                405                 410                 415     


Gly Gln Thr Val Gln Gln Val Tyr Asn Ala Val Gly Ala Leu Ala Lys 
            420                 425                 430         


Ala Val Tyr Glu Lys Met Phe Leu Trp Met Val Thr Arg Ile Asn Gln 
        435                 440                 445             


Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp 
    450                 455                 460                 


Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys 
465                 470                 475                 480 


Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met 
                485                 490                 495     


Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr 
            500                 505                 510         


Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu 
        515                 520                 525             


Lys Pro Leu Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro 
    530                 535                 540                 


Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu 
545                 550                 555                 560 


Gly Lys Ser Ala Asn Phe Gln Lys Pro Lys Val Val Lys Gly Lys Ala 
                565                 570                 575     


Glu Ala His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn 
            580                 585                 590         


Ile Thr Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Asp Thr Val 
        595                 600                 605             


Val Gly Leu Tyr Gln Lys Ser Ala Met Lys Thr Leu Ala Ser Leu Phe 
    610                 615                 620                 


Ser Thr Tyr Ala Ser Ala Glu Ala Asp Ser Ser Ala Lys Lys Gly Ala 
625                 630                 635                 640 


Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg Glu 
                645                 650                 655     


Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His Phe 
            660                 665                 670         


Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met Glu 
        675                 680                 685             


His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly 
    690                 695                 700                 


Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Gly Asp 
705                 710                 715                 720 


Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile Pro Glu Gly 
                725                 730                 735     


Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu Ala Ser Ile 
            740                 745                 750         


Asp Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe 
        755                 760                 765             


Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Lys Leu 
    770                 775                 780                 


Ala Gln Ile Ile Thr Arg Thr Gln Ala Val Cys Arg Gly Phe Leu Met 
785                 790                 795                 800 


Arg Val Glu Tyr Gln Lys Met Leu Gln Arg Arg Glu Ala Leu Phe Cys 
                805                 810                 815     


Ile Gln Tyr Asn Val Arg Ala Phe Met Asn Val Lys His Trp Pro Trp 
            820                 825                 830         


Met Lys Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr 
        835                 840                 845             


Glu Lys Glu Met Ala Thr Met Lys Glu Glu Phe Gln Lys Thr Lys Asp 
    850                 855                 860                 


Glu Leu Ala Lys Ser Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys Met 
865                 870                 875                 880 


Val Thr Leu Leu Lys Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ser 
                885                 890                 895     


Glu Ala Asp Ser Leu Ala Asp Ala Glu Glu Arg Cys Glu Gln Leu Ile 
            900                 905                 910         


Lys Asn Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Val Thr Glu Arg 
        915                 920                 925             


Ala Glu Glu Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys Arg 
    930                 935                 940                 


Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu 
945                 950                 955                 960 


Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn 
                965                 970                 975     


Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Thr Ile 
            980                 985                 990         


Ala Lys Leu Ser Lys Glu Lys Lys  Ala Leu Gln Glu Thr  His Gln Gln 
        995                 1000                 1005             


Thr Leu  Asp Asp Leu Gln Ala  Glu Glu Asp Lys Val  Asn Ile Leu 
    1010                 1015                 1020             


Thr Lys  Ala Lys Thr Lys Leu  Glu Gln Gln Val Asp  Asp Leu Glu 
    1025                 1030                 1035             


Gly Ser  Leu Glu Gln Glu Lys  Lys Leu Arg Met Asp  Leu Glu Arg 
    1040                 1045                 1050             


Ala Lys  Arg Lys Leu Glu Gly  Asp Leu Lys Leu Ala  Gln Glu Ser 
    1055                 1060                 1065             


Thr Met  Asp Met Glu Asn Asp  Lys Gln Gln Leu Asp  Glu Lys Leu 
    1070                 1075                 1080             


Glu Lys  Lys Glu Phe Glu Ile  Ser Asn Leu Ile Ser  Lys Ile Glu 
    1085                 1090                 1095             


Asp Glu  Gln Ala Val Glu Ile  Gln Leu Gln Lys Lys  Ile Lys Glu 
    1100                 1105                 1110             


Leu Gln  Ala Arg Ile Glu Glu  Leu Gly Glu Glu Ile  Glu Ala Glu 
    1115                 1120                 1125             


Arg Ala  Ser Arg Ala Lys Ala  Glu Lys Gln Arg Ser  Asp Leu Ser 
    1130                 1135                 1140             


Arg Glu  Leu Glu Glu Ile Ser  Glu Arg Leu Glu Glu  Ala Gly Gly 
    1145                 1150                 1155             


Ala Thr  Ser Ala Gln Val Glu  Leu Asn Lys Lys Arg  Glu Ala Glu 
    1160                 1165                 1170             


Phe Gln  Lys Leu Arg Arg Asp  Leu Glu Glu Ala Thr  Leu Gln His 
    1175                 1180                 1185             


Glu Ala  Met Val Ala Ala Leu  Arg Lys Lys His Ala  Asp Ser Met 
    1190                 1195                 1200             


Ala Glu  Leu Gly Glu Gln Ile  Asp Asn Leu Gln Arg  Val Lys Gln 
    1205                 1210                 1215             


Lys Leu  Glu Lys Glu Lys Ser  Glu Leu Lys Met Glu  Thr Asp Asp 
    1220                 1225                 1230             


Leu Ser  Ser Asn Ala Glu Ala  Ile Ser Lys Ala Lys  Gly Asn Leu 
    1235                 1240                 1245             


Glu Lys  Met Cys Arg Ser Leu  Glu Asp Gln Val Ser  Glu Leu Lys 
    1250                 1255                 1260             


Thr Lys  Glu Glu Glu Gln Gln  Arg Leu Ile Asn Asp  Leu Thr Ala 
    1265                 1270                 1275             


Gln Arg  Ala Arg Leu Gln Thr  Glu Ala Gly Glu Tyr  Ser Arg Gln 
    1280                 1285                 1290             


Leu Asp  Glu Lys Asp Ala Leu  Val Ser Gln Leu Ser  Arg Ser Lys 
    1295                 1300                 1305             


Gln Ala  Ser Thr Gln Gln Ile  Glu Glu Leu Lys His  Gln Leu Glu 
    1310                 1315                 1320             


Glu Glu  Thr Lys Ala Lys Asn  Ala Leu Ala His Ala  Leu Gln Ser 
    1325                 1330                 1335             


Ser Arg  His Asp Cys Asp Leu  Leu Arg Glu Gln Tyr  Glu Glu Glu 
    1340                 1345                 1350             


Gln Glu  Gly Lys Ala Glu Leu  Gln Arg Ala Leu Ser  Lys Ala Asn 
    1355                 1360                 1365             


Ser Glu  Val Ala Gln Trp Arg  Thr Lys Tyr Glu Thr  Asp Ala Ile 
    1370                 1375                 1380             


Gln Arg  Thr Glu Glu Leu Glu  Glu Ala Lys Lys Lys  Leu Ala Gln 
    1385                 1390                 1395             


Arg Leu  Gln Glu Ala Glu Glu  His Val Glu Ala Val  Asn Ala Lys 
    1400                 1405                 1410             


Cys Ala  Ser Leu Glu Lys Thr  Lys Gln Arg Leu Gln  Asn Glu Val 
    1415                 1420                 1425             


Glu Asp  Leu Met Leu Asp Val  Glu Arg Ser Asn Ala  Ala Cys Ala 
    1430                 1435                 1440             


Ala Leu  Asp Lys Lys Gln Arg  Asn Phe Asp Lys Val  Leu Ser Glu 
    1445                 1450                 1455             


Trp Lys  Gln Lys Tyr Glu Glu  Thr Gln Ala Glu Leu  Glu Ala Ser 
    1460                 1465                 1470             


Gln Lys  Glu Ser Arg Ser Leu  Ser Thr Glu Leu Phe  Lys Val Lys 
    1475                 1480                 1485             


Asn Val  Tyr Glu Glu Ser Leu  Asp Gln Leu Glu Thr  Leu Arg Arg 
    1490                 1495                 1500             


Glu Asn  Lys Asn Leu Gln Gln  Glu Ile Ser Asp Leu  Thr Glu Gln 
    1505                 1510                 1515             


Ile Ala  Glu Gly Gly Lys Gln  Ile His Glu Leu Glu  Lys Ile Lys 
    1520                 1525                 1530             


Lys Gln  Val Glu Gln Glu Lys  Cys Glu Ile Gln Ala  Ala Leu Glu 
    1535                 1540                 1545             


Glu Ala  Glu Ala Ser Leu Glu  His Glu Glu Gly Lys  Ile Leu Arg 
    1550                 1555                 1560             


Ile Gln  Leu Glu Leu Asn Gln  Val Lys Ser Glu Val  Asp Arg Lys 
    1565                 1570                 1575             


Ile Ala  Glu Lys Asp Glu Glu  Ile Asp Gln Leu Lys  Arg Asn His 
    1580                 1585                 1590             


Thr Arg  Val Val Glu Thr Met  Gln Ser Thr Leu Asp  Ala Glu Ile 
    1595                 1600                 1605             


Arg Ser  Arg Asn Asp Ala Leu  Arg Val Lys Lys Lys  Met Glu Gly 
    1610                 1615                 1620             


Asp Leu  Asn Glu Met Glu Ile  Gln Leu Asn His Ala  Asn Arg Leu 
    1625                 1630                 1635             


Ala Ala  Glu Ser Leu Arg Asn  Tyr Arg Asn Thr Gln  Gly Ile Leu 
    1640                 1645                 1650             


Lys Glu  Thr Gln Leu His Leu  Asp Asp Ala Leu Arg  Gly Gln Glu 
    1655                 1660                 1665             


Asp Leu  Lys Glu Gln Leu Ala  Ile Val Glu Arg Arg  Ala Asn Leu 
    1670                 1675                 1680             


Leu Gln  Ala Glu Ile Glu Glu  Leu Trp Ala Thr Leu  Glu Gln Thr 
    1685                 1690                 1695             


Glu Arg  Ser Arg Lys Ile Ala  Glu Gln Glu Leu Leu  Asp Ala Ser 
    1700                 1705                 1710             


Glu Arg  Val Gln Leu Leu His  Thr Gln Asn Thr Ser  Leu Ile Asn 
    1715                 1720                 1725             


Thr Lys  Lys Lys Leu Glu Asn  Asp Val Ser Gln Leu  Gln Ser Glu 
    1730                 1735                 1740             


Val Glu  Glu Val Ile Gln Glu  Ser Arg Asn Ala Glu  Glu Lys Ala 
    1745                 1750                 1755             


Lys Lys  Ala Ile Thr Asp Ala  Ala Met Met Ala Glu  Glu Leu Lys 
    1760                 1765                 1770             


Lys Glu  Gln Asp Thr Ser Ala  His Leu Glu Arg Met  Lys Lys Asn 
    1775                 1780                 1785             


Leu Glu  Gln Thr Val Lys Asp  Leu Gln His Arg Leu  Asp Glu Ala 
    1790                 1795                 1800             


Glu Gln  Leu Ala Leu Lys Gly  Gly Lys Lys Gln Ile  Gln Lys Leu 
    1805                 1810                 1815             


Glu Ala  Arg Val Arg Glu Leu  Glu Gly Glu Val Glu  Asn Glu Gln 
    1820                 1825                 1830             


Lys Arg  Asn Ala Glu Ala Val  Lys Gly Leu Arg Lys  His Glu Arg 
    1835                 1840                 1845             


Arg Val  Lys Glu Leu Thr Tyr  Gln Thr Glu Glu Asp  Arg Lys Asn 
    1850                 1855                 1860             


Val Leu  Arg Leu Gln Asp Leu  Val Asp Lys Leu Gln  Ala Lys Val 
    1865                 1870                 1875             


Lys Ser  Tyr Lys Arg Gln Ala  Glu Glu Ala Glu Glu  Gln Ser Asn 
    1880                 1885                 1890             


Ala Asn  Leu Ser Lys Phe Arg  Lys Leu Gln His Glu  Leu Glu Glu 
    1895                 1900                 1905             


Ala Glu  Glu Arg Ala His Ile  Ala Glu Ser Gln Val  Asn Lys Leu 
    1910                 1915                 1920             


Arg Val  Lys Ser Arg Glu Val  His Thr Lys Ile Ser  Ala Glu 
    1925                 1930                 1935         


<210> 46
<211> 30
<212> PRT
<213> Homo sapiens


<220>
<223> N-term acetylated

<400> 46
Ser Leu Lys Leu Met Ala Thr Leu Phe Ser Thr Tyr Ala Ser Ala Asp 
1               5                   10                  15      


Thr Gly Asp Ser Gly Lys Gly Lys Gly Gly Lys Lys Lys Gly 
            20                  25                  30  


<210> 47
<211> 14
<212> PRT
<213> Homo sapiens

<400> 47
Gly Gln Phe Ile Asp Ser Gly Lys Ala Gly Ala Glu Lys Leu 
1               5                   10                  


<210> 48
<211> 14
<212> PRT
<213> Homo sapiens

<400> 48
Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu Glu 
1               5                   10                  


<210> 49
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 49
Met Gly Ala Gln Val Ser Thr Gln Lys Thr Gly Ala His Glu Thr Ser 
1               5                   10                  15      


Leu Ser Ala Ser 
            20  


<210> 50
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 50
Gly Asn Ser Ile Ile His Tyr Thr Asn Ile Asn Tyr Tyr Lys Asp Ala 
1               5                   10                  15      


Ala Ser Asn Ser 
            20  


<210> 51
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 51
Asn Tyr Tyr Lys Asp Ala Ala Ser Asn Ser Ala Asn Arg Gln Asp Phe 
1               5                   10                  15      


Thr Gln Asp Pro 
            20  


<210> 52
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 52
Ala Asn Arg Gln Asp Phe Thr Gln Asp Pro Ser Lys Phe Thr Glu Pro 
1               5                   10                  15      


Val Lys Asp Val 
            20  


<210> 53
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 53
Ser Lys Phe Thr Glu Pro Val Lys Asp Val Met Ile Lys Ser Leu Pro 
1               5                   10                  15      


Ala Leu Asn Ser 
            20  


<210> 54
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 54
Met Ile Lys Ser Leu Pro Ala Leu Asn Ser Pro Thr Val Glu Glu Cys 
1               5                   10                  15      


Gly Tyr Ser Asp 
            20  


<210> 55
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 55
Pro Thr Val Glu Glu Cys Gly Tyr Ser Asp Arg Val Arg Ser Ile Thr 
1               5                   10                  15      


Leu Gly Asn Ser 
            20  


<210> 56
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 56
Arg Val Arg Ser Ile Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
1               5                   10                  15      


Cys Ala Asn Val 
            20  


<210> 57
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 57
Thr Ile Thr Thr Gln Glu Cys Ala Asn Val Val Val Gly Tyr Gly Val 
1               5                   10                  15      


Trp Pro Asp Tyr 
            20  


<210> 58
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 58
Leu Ser Asp Glu Glu Ala Thr Ala Glu Asp Gln Pro Thr Gln Pro Asp 
1               5                   10                  15      


Val Ala Thr Cys 
            20  


<210> 59
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 59
Gln Pro Thr Gln Pro Asp Val Ala Thr Cys Arg Phe Tyr Thr Leu Asn 
1               5                   10                  15      


Ser Val Lys Trp 
            20  


<210> 60
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 60
Arg Phe Tyr Thr Leu Asn Ser Val Lys Trp Glu Met Gln Ser Ala Gly 
1               5                   10                  15      


Trp Trp Trp Lys 
            20  


<210> 61
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 61
Phe Pro Asp Ala Leu Ser Glu Met Gly Leu Phe Gly Gln Asn Met Gln 
1               5                   10                  15      


Tyr His Tyr Leu 
            20  


<210> 62
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 62
Phe Gly Gln Asn Met Gln Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr 
1               5                   10                  15      


Ile His Val Gln 
            20  


<210> 63
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 63
Gly Arg Ser Gly Tyr Thr Ile His Val Gln Cys Asn Ala Ser Lys Phe 
1               5                   10                  15      


His Gln Gly Cys 
            20  


<210> 64
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 64
Cys Asn Ala Ser Lys Phe His Gln Gly Cys Leu Leu Val Val Cys Val 
1               5                   10                  15      


Pro Glu Ala Glu 
            20  


<210> 65
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 65
Ala Tyr Gly Asp Leu Cys Gly Gly Glu Thr Ala Lys Ser Phe Glu Gln 
1               5                   10                  15      


Asn Ala Ala Thr 
            20  


<210> 66
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 66
Ala Lys Ser Phe Glu Gln Asn Ala Ala Thr Gly Lys Thr Ala Val Gln 
1               5                   10                  15      


Thr Ala Val Cys 
            20  


<210> 67
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 67
Gly Lys Thr Ala Val Gln Thr Ala Val Cys Asn Ala Gly Met Gly Val 
1               5                   10                  15      


Gly Val Gly Asn 
            20  


<210> 68
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 68
Leu Thr Ile Tyr Pro His Gln Trp Ile Asn Leu Arg Thr Asn Asn Ser 
1               5                   10                  15      


Ala Thr Ile Val 
            20  


<210> 69
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 69
Leu Arg Thr Asn Asn Ser Ala Thr Ile Val Met Pro Tyr Ile Asn Ser 
1               5                   10                  15      


Val Pro Met Asp 
            20  


<210> 70
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 70
Met Pro Tyr Ile Asn Ser Val Pro Met Asp Asn Met Phe Arg His Asn 
1               5                   10                  15      


Asn Phe Thr Leu 
            20  


<210> 71
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 71
Asn Met Phe Arg His Asn Asn Phe Thr Leu Met Ile Ile Pro Phe Ala 
1               5                   10                  15      


Pro Leu Asp Tyr 
            20  


<210> 72
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 72
Tyr Asn Gly Leu Arg Leu Ala Gly His Gln Gly Leu Pro Thr Met Leu 
1               5                   10                  15      


Thr Pro Gly Ser 
            20  


<210> 73
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 73
Ser Pro Ser Ala Met Pro Gln Phe Asp Val Thr Pro Glu Met Asn Ile 
1               5                   10                  15      


Pro Gly Gln Val 
            20  


<210> 74
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 74
Thr Pro Glu Met Asn Ile Pro Gly Gln Val Arg Asn Leu Met Glu Ile 
1               5                   10                  15      


Ala Glu Val Asp 
            20  


<210> 75
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 75
Arg Asn Leu Met Glu Ile Ala Glu Val Asp Ser Val Val Pro Ile Asn 
1               5                   10                  15      


Asn Leu Lys Ala 
            20  


<210> 76
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 76
Ser Val Val Pro Ile Asn Asn Leu Lys Ala Asn Leu Met Thr Met Glu 
1               5                   10                  15      


Ala Tyr Arg Val 
            20  


<210> 77
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 77
Asn Leu Met Thr Met Glu Ala Tyr Arg Val Gln Val Arg Ser Thr Asp 
1               5                   10                  15      


Glu Met Gly Gly 
            20  


<210> 78
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 78
Gln Val Arg Ser Thr Asp Glu Met Gly Gly Gln Ile Phe Gly Phe Pro 
1               5                   10                  15      


Leu Gln Pro Gly 
            20  


<210> 79
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 79
Gln Ile Phe Gly Phe Pro Leu Gln Pro Gly Ala Ser Ser Val Leu Gln 
1               5                   10                  15      


Arg Thr Leu Leu 
            20  


<210> 80
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 80
Ala Ser Ser Val Leu Gln Arg Thr Leu Leu Gly Glu Ile Leu Asn Tyr 
1               5                   10                  15      


Tyr Thr His Trp 
            20  


<210> 81
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 81
Gly Glu Ile Leu Asn Tyr Tyr Thr His Trp Ser Gly Ser Leu Lys Leu 
1               5                   10                  15      


Thr Phe Val Phe 
            20  


<210> 82
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 82
Ser Gly Ser Leu Lys Leu Thr Phe Val Phe Cys Gly Ser Ala Met Ala 
1               5                   10                  15      


Thr Gly Lys Phe 
            20  


<210> 83
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 83
Asp Asp Lys Tyr Thr Ala Ser Gly Phe Ile Ser Cys Trp Tyr Gln Thr 
1               5                   10                  15      


Asn Val Ile Val 
            20  


<210> 84
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 84
Met Cys Phe Val Ser Ala Cys Asn Asp Phe Ser Val Arg Met Leu Arg 
1               5                   10                  15      


Asp Thr Gln Phe 
            20  


<210> 85
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 85
Leu Arg Arg Lys Met Glu Met Phe Thr Tyr Ile Arg Cys Asp Met Glu 
1               5                   10                  15      


Leu Thr Phe Val 
            20  


<210> 86
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 86
Val Pro Thr Ser Val Asn Asp Tyr Val Trp Gln Thr Ser Thr Asn Pro 
1               5                   10                  15      


Ser Ile Phe Trp 
            20  


<210> 87
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 87
Gln Thr Ser Thr Asn Pro Ser Ile Phe Trp Thr Glu Gly Asn Ala Pro 
1               5                   10                  15      


Pro Arg Met Ser 
            20  


<210> 88
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 88
Thr Glu Gly Asn Ala Pro Pro Arg Met Ser Ile Pro Phe Met Ser Ile 
1               5                   10                  15      


Gly Asn Ala Tyr 
            20  


<210> 89
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 89
Ile Pro Phe Met Ser Ile Gly Asn Ala Tyr Thr Met Phe Tyr Asp Gly 
1               5                   10                  15      


Trp Ser Asn Phe 
            20  


<210> 90
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 90
Ser Arg Asp Gly Ile Tyr Gly Tyr Asn Ser Leu Asn Asn Met Gly Thr 
1               5                   10                  15      


Ile Tyr Ala Arg 
            20  


<210> 91
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 91
Leu Asn Asn Met Gly Thr Ile Tyr Ala Arg His Val Asn Asp Ser Ser 
1               5                   10                  15      


Pro Gly Gly Leu 
            20  


<210> 92
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 92
His Val Asn Asp Ser Ser Pro Gly Gly Leu Thr Ser Thr Ile Arg Ile 
1               5                   10                  15      


Tyr Phe Lys Pro 
            20  


<210> 93
<211> 20
<212> PRT
<213> Coxsackievirus

<400> 93
Ser Val Asn Phe Asp Val Glu Ala Val Thr Ala Glu Arg Ala Ser Leu 
1               5                   10                  15      


Ile Thr Thr Gly 
            20  


<210> 94
<211> 19
<212> PRT
<213> Coxsackievirus

<400> 94
Gly Leu Lys Thr Glu Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly Leu 
1               5                   10                  15      


Lys Thr Glu 
            


<210> 95
<211> 18
<212> PRT
<213> Coxsackievirus

<400> 95
Lys Lys Glu His Glu Ala Glu Asn Asp Lys Leu Lys Gln Gln Arg Asp 
1               5                   10                  15      


Thr Leu 
        


<210> 96
<211> 18
<212> PRT
<213> Coxsackievirus

<400> 96
Val Lys Asp Lys Ile Ala Lys Glu Gln Glu Asn Lys Glu Thr Ile Gly 
1               5                   10                  15      


Thr Leu 
        


<210> 97
<211> 18
<212> PRT
<213> Coxsackievirus

<400> 97
Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys 
1               5                   10                  15      


Ile Ala 
        


<210> 98
<211> 18
<212> PRT
<213> Coxsackievirus

<400> 98
Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys Leu 
1               5                   10                  15      


Ala Lys 
        


<210> 99
<211> 16
<212> PRT
<213> Coxsackievirus

<400> 99
Lys Gly Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln 
1               5                   10                  15      


<210> 100
<211> 18
<212> PRT
<213> Coxsackievirus

<400> 100
Leu Lys Thr Lys Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly Leu Lys 
1               5                   10                  15      


Thr Glu 
        


<210> 101
<211> 18
<212> PRT
<213> Coxsackievirus

<400> 101
Lys Lys Glu His Glu Ala Glu Asn Asp Lys Leu Lys Gln Gln Arg Asp 
1               5                   10                  15      


Thr Leu 
        


<210> 102
<211> 18
<212> PRT
<213> Coxsackievirus

<400> 102
Gln Arg Asp Thr Leu Ser Thr Gln Lys Glu Thr Leu Glu Arg Glu Val 
1               5                   10                  15      


Gln Asn 
        


<210> 103
<211> 18
<212> PRT
<213> Coxsackievirus

<400> 103
Arg Glu Val Gln Asn Thr Gln Tyr Asn Asn Glu Thr Leu Lys Ile Lys 
1               5                   10                  15      


Asn Gly 
        


<210> 104
<211> 18
<212> PRT
<213> Coxsackievirus

<400> 104
Lys Ile Lys Asn Gly Asp Leu Thr Lys Glu Leu Asn Lys Thr Arg Gln 
1               5                   10                  15      


Glu Leu 
        


<210> 105
<211> 19
<212> PRT
<213> Coxsackievirus

<400> 105
Thr Arg Gln Glu Leu Ala Asn Lys Gln Gln Glu Ser Lys Glu Asn Glu 
1               5                   10                  15      


Lys Ala Leu 
            


<210> 106
<211> 18
<212> PRT
<213> Coxsackievirus

<400> 106
Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys 
1               5                   10                  15      


Ile Ala 
        


<210> 107
<211> 18
<212> PRT
<213> Coxsackievirus

<400> 107
Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys Leu 
1               5                   10                  15      


Ala Lys 
        


<210> 108
<211> 35
<212> PRT
<213> Coxsackievirus

<400> 108
Ala Val Thr Arg Gly Thr Ile Asn Asp Pro Gln Arg Ala Lys Glu Ala 
1               5                   10                  15      


Leu Asp Lys Tyr Glu Leu Glu Asn His Asp Leu Lys Thr Lys Asn Glu 
            20                  25                  30          


Gly Leu Lys 
        35  


<210> 109
<211> 27
<212> PRT
<213> Coxsackievirus

<400> 109
Lys Thr Lys Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly Leu Lys Thr 
1               5                   10                  15      


Glu Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly 
            20                  25          


<210> 110
<211> 16
<212> PRT
<213> Coxsackievirus

<400> 110
Leu Lys Thr Glu Lys Lys Glu His Glu Ala Glu Asn Asp Lys Leu Lys 
1               5                   10                  15      


<210> 111
<211> 30
<212> PRT
<213> Coxsackievirus

<400> 111
Asp Leu Thr Lys Glu Leu Asn Lys Thr Arg Gln Glu Leu Ala Asn Lys 
1               5                   10                  15      


Gln Gln Glu Ser Lys Glu Asn Glu Lys Ala Ile Asn Glu Leu 
            20                  25                  30  


<210> 112
<211> 30
<212> PRT
<213> Coxsackievirus

<400> 112
Leu Glu Lys Thr Val Lys Asp Lys Ile Ala Lys Glu Gln Glu Asn Lys 
1               5                   10                  15      


Glu Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val 
            20                  25                  30  


<210> 113
<211> 16
<212> PRT
<213> Coxsackievirus

<400> 113
Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys 
1               5                   10                  15      


<210> 114
<211> 21
<212> PRT
<213> Streptococcus pyogenes

<400> 114
Ile Ser Asp Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu Asp Ala Ser 
1               5                   10                  15      


Arg Glu Ala Lys Lys 
            20      


<210> 115
<211> 20
<212> PRT
<213> Streptococcus pyogenes

<400> 115
Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Ile Glu Glu 
1               5                   10                  15      


Ala Asn Ser Lys 
            20  


<210> 116
<211> 20
<212> PRT
<213> Streptococcus pyogenes

<400> 116
Ala Leu Glu Glu Ala Asn Ser Lys Leu Ala Ala Leu Glu Lys Leu Asn 
1               5                   10                  15      


Lys Glu Leu Glu 
            20  


<210> 117
<211> 31
<212> PRT
<213> Streptococcus pyogenes

<400> 117
Glu Leu Glu Glu Ser Lys Lys Leu Thr Glu Lys Glu Lys Ala Glu Leu 
1               5                   10                  15      


Gln Ala Lys Leu Glu Ala Glu Ala Lys Gln Leu Lys Glu Gln Leu 
            20                  25                  30      


<210> 118
<211> 30
<212> PRT
<213> Streptococcus pyogenes

<400> 118
Ala Lys Gln Ala Glu Glu Leu Ala Lys Leu Arg Ala Gly Lys Ala Ser 
1               5                   10                  15      


Asp Ser Gln Thr Pro Asp Thr Lys Pro Gly Asn Lys Ala Val 
            20                  25                  30  


<210> 119
<211> 37
<212> PRT
<213> Streptococcus pyogenes

<400> 119
Val Pro Gly Lys Gly Gln Ala Pro Gln Ala Gly Thr Lys Pro Asn Gln 
1               5                   10                  15      


Asn Lys Ala Pro Met Lys Glu Thr Lys Arg Gln Leu Pro Ser Thr Gly 
            20                  25                  30          


Glu Thr Ala Asn Pro 
        35          


<210> 120
<211> 19
<212> PRT
<213> Streptococcus pyogenes

<400> 120
Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu 
1               5                   10                  15      


Lys Ala Ile 
            


<210> 121
<211> 20
<212> PRT
<213> Streptococcus pyogenes

<400> 121
Ala Lys Lys Gln Val Glu Lys Ala Leu Glu Glu Ala Asn Ser Lys Leu 
1               5                   10                  15      


Ala Ala Leu Glu 
            20  


<210> 122
<211> 20
<212> PRT
<213> Streptococcus pyogenes

<400> 122
Lys Leu Thr Glu Lys Glu Lys Ala Glu Leu Gln Ala Lys Leu Glu Ala 
1               5                   10                  15      


Glu Ala Lys Ala 
            20  


<210> 123
<211> 20
<212> PRT
<213> Streptococcus pyogenes

<400> 123
Gln Ala Lys Leu Glu Ala Glu Ala Lys Ala Leu Lys Glu Gln Leu Ala 
1               5                   10                  15      


Lys Gln Ala Glu 
            20  


<210> 124
<211> 20
<212> PRT
<213> Streptococcus pyogenes

<400> 124
Leu Lys Glu Gln Leu Ala Lys Gln Ala Glu Glu Leu Ala Lys Leu Arg 
1               5                   10                  15      


Ala Gly Lys Ala 
            20  


<210> 125
<211> 25
<212> PRT
<213> Streptococcus pyogenes

<400> 125
Thr Val Thr Arg Gly Thr Ile Ser Asp Pro Gln Arg Ala Lys Glu Ala 
1               5                   10                  15      


Leu Asp Lys Tyr Glu Leu Glu Asn His 
            20                  25  


<210> 126
<211> 24
<212> PRT
<213> Streptococcus pyogenes

<400> 126
Asp Lys Leu Lys Gln Gln Arg Asp Thr Leu Ser Thr Gln Lys Glu Thr 
1               5                   10                  15      


Leu Glu Arg Glu Val Gln Asn Ile 
            20                  


<210> 127
<211> 15
<212> PRT
<213> Streptococcus pyogenes

<400> 127
Glu Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys 
1               5                   10                  15  


<210> 128
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 128
Ala Val Thr Arg Gly Thr Ile Asn Asp Pro Gln Arg Ala Lys Glu Ala 
1               5                   10                  15      


Leu Asp 
        


<210> 129
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 129
Lys Glu Ala Leu Asp Lys Tyr Glu Leu Glu Asn His Asp Leu Lys Thr 
1               5                   10                  15      


Lys Asn 
        


<210> 130
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 130
Leu Lys Thr Lys Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly Leu Lys 
1               5                   10                  15      


Thr Glu 
        


<210> 131
<211> 19
<212> PRT
<213> Streptococcus pyogenes

<400> 131
Gly Leu Lys Thr Glu Asn Glu Gly Leu Lys Thr Glu Asn Glu Gly Leu 
1               5                   10                  15      


Lys Thr Glu 
            


<210> 132
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 132
Lys Lys Glu His Glu Ala Glu Asn Asp Lys Leu Lys Gln Gln Arg Asp 
1               5                   10                  15      


Thr Leu 
        


<210> 133
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 133
Gln Arg Asp Thr Leu Ser Thr Gln Lys Glu Thr Leu Glu Arg Glu Val 
1               5                   10                  15      


Gln Asn 
        


<210> 134
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 134
Arg Glu Val Gln Asn Thr Gln Tyr Asn Asn Glu Thr Leu Lys Ile Lys 
1               5                   10                  15      


Asn Gly 
        


<210> 135
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 135
Lys Ile Lys Asn Gly Asp Leu Thr Lys Glu Leu Asn Lys Thr Arg Gln 
1               5                   10                  15      


Glu Leu 
        


<210> 136
<211> 19
<212> PRT
<213> Streptococcus pyogenes

<400> 136
Thr Arg Gln Glu Leu Ala Asn Lys Gln Gln Glu Ser Lys Glu Asn Glu 
1               5                   10                  15      


Lys Ala Leu 
            


<210> 137
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 137
Glu Asn Glu Lys Ala Leu Asn Glu Leu Leu Glu Lys Thr Val Lys Asp 
1               5                   10                  15      


Lys Ile 
        


<210> 138
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 138
Val Lys Asp Lys Ile Ala Lys Glu Gln Glu Asn Lys Glu Thr Ile Gly 
1               5                   10                  15      


Thr Leu 
        


<210> 139
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 139
Thr Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys 
1               5                   10                  15      


Ile Ala 
        


<210> 140
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 140
Lys Asp Lys Ile Ala Lys Glu Gln Glu Asn Lys Glu Thr Ile Gly Thr 
1               5                   10                  15      


Leu Lys 
        


<210> 141
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 141
Ile Gly Thr Leu Lys Lys Ile Leu Asp Glu Thr Val Lys Asp Lys Leu 
1               5                   10                  15      


Ala Lys 
        


<210> 142
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 142
Asp Lys Leu Ala Lys Glu Gln Lys Ser Lys Gln Asn Ile Gly Ala Leu 
1               5                   10                  15      


Lys Gln 
        


<210> 143
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 143
Gly Ala Leu Lys Gln Glu Leu Ala Lys Lys Asp Glu Ala Asn Lys Ile 
1               5                   10                  15      


Ser Asp 
        


<210> 144
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 144
Asn Lys Ile Ser Asp Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu Asp 
1               5                   10                  15      


Ala Ser 
        


<210> 145
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 145
Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Leu Glu Ala Glu His 
1               5                   10                  15      


Gln Lys 
        


<210> 146
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 146
Ala Glu His Gln Lys Leu Glu Glu Gln Asn Lys Ile Ser Glu Ala Ser 
1               5                   10                  15      


Arg Lys 
        


<210> 147
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 147
Glu Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu 
1               5                   10                  15      


Ala Lys 
        


<210> 148
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 148
Ser Arg Glu Ala Lys Lys Gln Leu Glu Ala Glu Gln Gln Lys Leu Glu 
1               5                   10                  15      


Glu Gln 
        


<210> 149
<211> 18
<212> PRT
<213> Streptococcus pyogenes

<400> 149
Lys Leu Glu Glu Gln Asn Lys Ile Ser Glu Ala Ser Arg Lys Gly Leu 
1               5                   10                  15      


Arg Arg 
        


<210> 150
<211> 16
<212> PRT
<213> Streptococcus pyogenes

<400> 150
Lys Gly Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln 
1               5                   10                  15      


<210> 151
<211> 1487
<212> PRT
<213> Homo sapiens

<400> 151
Met Ile Arg Leu Gly Ala Pro Gln Thr Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Gln Glu Ala Gly 
            20                  25                  30          


Ser Cys Val Gln Asp Gly Gln Arg Tyr Asn Asp Lys Asp Val Trp Lys 
        35                  40                  45              


Pro Glu Pro Cys Arg Ile Cys Val Cys Asp Thr Gly Thr Val Leu Cys 
    50                  55                  60                  


Asp Asp Ile Ile Cys Glu Asp Val Lys Asp Cys Leu Ser Pro Glu Ile 
65                  70                  75                  80  


Pro Phe Gly Glu Cys Cys Pro Ile Cys Pro Thr Asp Leu Ala Thr Ala 
                85                  90                  95      


Ser Gly Gln Pro Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile 
            100                 105                 110         


Lys Asp Ile Val Gly Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala 
        115                 120                 125             


Gly Glu Gln Gly Pro Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly 
    130                 135                 140                 


Ala Pro Gly Pro Arg Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn 
145                 150                 155                 160 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly 
                165                 170                 175     


Gly Asn Phe Ala Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly 
            180                 185                 190         


Gly Ala Gln Leu Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro 
        195                 200                 205             


Arg Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 
    210                 215                 220                 


Gly Asn Pro Gly Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly 
225                 230                 235                 240 


Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu 
                245                 250                 255     


Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln 
            260                 265                 270         


Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly 
        275                 280                 285             


His Arg Gly Tyr Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala 
    290                 295                 300                 


Pro Gly Val Lys Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro 
305                 310                 315                 320 


Gly Pro Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly 
                325                 330                 335     


Pro Ala Gly Ala Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro 
            340                 345                 350         


Ala Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Pro Gly Ala Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly 
    370                 375                 380                 


Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro 
                405                 410                 415     


Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly 
            420                 425                 430         


Phe Pro Gly Pro Arg Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro 
        435                 440                 445             


Leu Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys 
    450                 455                 460                 


Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly 
465                 470                 475                 480 


Ala Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu 
                485                 490                 495     


Pro Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Asn Arg Gly Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly 
        515                 520                 525             


Ala Pro Gly Glu Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala 
    530                 535                 540                 


Asn Gly Asp Pro Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg 
545                 550                 555                 560 


Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly 
                565                 570                 575     


Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 
            580                 585                 590         


Gln Gly Ala Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys 
        595                 600                 605             


Gly Ala Asn Gly Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly 
    610                 615                 620                 


Ala Pro Gly Leu Arg Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala 
625                 630                 635                 640 


Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln 
                645                 650                 655     


Gly Ala Pro Gly Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Glu Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro 
    690                 695                 700                 


Gly Glu Arg Gly Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Thr Pro Gly Thr Asp Gly Pro Lys Gly Ala Ser Gly Pro 
                725                 730                 735     


Ala Gly Pro Pro Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro 
            740                 745                 750         


Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly 
        755                 760                 765             


Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly 
    770                 775                 780                 


Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn 
785                 790                 795                 800 


Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly 
                805                 810                 815     


Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro 
            820                 825                 830         


Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys 
        835                 840                 845             


Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val 
865                 870                 875                 880 


Thr Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr 
                885                 890                 895     


Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly 
            900                 905                 910         


Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro 
        915                 920                 925             


Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 
    930                 935                 940                 


Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
945                 950                 955                 960 


Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu 
                965                 970                 975     


Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg 
            980                 985                 990         


Gly Phe Pro Gly Leu Pro Gly Pro  Ser Gly Glu Pro Gly  Lys Gln Gly 
        995                 1000                 1005             


Ala Pro  Gly Ala Ser Gly Asp  Arg Gly Pro Pro Gly  Pro Val Gly 
    1010                 1015                 1020             


Pro Pro  Gly Leu Thr Gly Pro  Ala Gly Glu Pro Gly  Arg Glu Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Asp Gly Pro  Pro Gly Arg Asp Gly  Ala Ala Gly 
    1040                 1045                 1050             


Val Lys  Gly Asp Arg Gly Glu  Thr Gly Ala Val Gly  Ala Pro Gly 
    1055                 1060                 1065             


Ala Pro  Gly Pro Pro Gly Ser  Pro Gly Pro Ala Gly  Pro Thr Gly 
    1070                 1075                 1080             


Lys Gln  Gly Asp Arg Gly Glu  Ala Gly Ala Gln Gly  Pro Met Gly 
    1085                 1090                 1095             


Pro Ser  Gly Pro Ala Gly Ala  Arg Gly Ile Gln Gly  Pro Gln Gly 
    1100                 1105                 1110             


Pro Arg  Gly Asp Lys Gly Glu  Ala Gly Glu Pro Gly  Glu Arg Gly 
    1115                 1120                 1125             


Leu Lys  Gly His Arg Gly Phe  Thr Gly Leu Gln Gly  Leu Pro Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Ser Gly Asp  Gln Gly Ala Ser Gly  Pro Ala Gly 
    1145                 1150                 1155             


Pro Ser  Gly Pro Arg Gly Pro  Pro Gly Pro Val Gly  Pro Ser Gly 
    1160                 1165                 1170             


Lys Asp  Gly Ala Asn Gly Ile  Pro Gly Pro Ile Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Arg  Gly Arg Ser Gly Glu  Thr Gly Pro Ala Gly  Pro Pro Gly 
    1190                 1195                 1200             


Asn Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Gly Ile 
    1205                 1210                 1215             


Asp Met  Ser Ala Phe Ala Gly  Leu Gly Pro Arg Glu  Lys Gly Pro 
    1220                 1225                 1230             


Asp Pro  Leu Gln Tyr Met Arg  Ala Asp Gln Ala Ala  Gly Gly Leu 
    1235                 1240                 1245             


Arg Gln  His Asp Ala Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1250                 1255                 1260             


Asn Gln  Ile Glu Ser Ile Arg  Ser Pro Glu Gly Ser  Arg Lys Asn 
    1265                 1270                 1275             


Pro Ala  Arg Thr Cys Arg Asp  Leu Lys Leu Cys His  Pro Glu Trp 
    1280                 1285                 1290             


Lys Ser  Gly Asp Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Leu 
    1295                 1300                 1305             


Asp Ala  Met Lys Val Phe Cys  Asn Met Glu Thr Gly  Glu Thr Cys 
    1310                 1315                 1320             


Val Tyr  Pro Asn Pro Ala Asn  Val Pro Lys Lys Asn  Trp Trp Ser 
    1325                 1330                 1335             


Ser Lys  Ser Lys Glu Lys Lys  His Ile Trp Phe Gly  Glu Thr Ile 
    1340                 1345                 1350             


Asn Gly  Gly Phe His Phe Ser  Tyr Gly Asp Asp Asn  Leu Ala Pro 
    1355                 1360                 1365             


Asn Thr  Ala Asn Val Gln Met  Thr Phe Leu Arg Leu  Leu Ser Thr 
    1370                 1375                 1380             


Glu Gly  Ser Gln Asn Ile Thr  Tyr His Cys Lys Asn  Ser Ile Ala 
    1385                 1390                 1395             


Tyr Leu  Asp Glu Ala Ala Gly  Asn Leu Lys Lys Ala  Leu Leu Ile 
    1400                 1405                 1410             


Gln Gly  Ser Asn Asp Val Glu  Ile Arg Ala Glu Gly  Asn Ser Arg 
    1415                 1420                 1425             


Phe Thr  Tyr Thr Ala Leu Lys  Asp Gly Cys Thr Lys  His Thr Gly 
    1430                 1435                 1440             


Lys Trp  Gly Lys Thr Val Ile  Glu Tyr Arg Ser Gln  Lys Thr Ser 
    1445                 1450                 1455             


Arg Leu  Pro Ile Ile Asp Ile  Ala Pro Met Asp Ile  Gly Gly Pro 
    1460                 1465                 1470             


Glu Gln  Glu Phe Gly Val Asp  Ile Gly Pro Val Cys  Phe Leu 
    1475                 1480                 1485         


<210> 152
<211> 8
<212> PRT
<213> Homo sapiens

<400> 152
Ala Gly Glu Arg Gly Pro Pro Gly 
1               5               


<210> 153
<211> 15
<212> PRT
<213> Homo sapiens

<400> 153
Ala Gly Gly Phe Asp Glu Lys Ala Gly Gly Ala Gln Leu Gly Val 
1               5                   10                  15  


<210> 154
<211> 11
<212> PRT
<213> Homo sapiens

<400> 154
Val Gly Pro Ala Gly Gly Pro Gly Phe Pro Gly 
1               5                   10      


<210> 155
<211> 12
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (5)..(5)
<223> 3, 5, 3', 5'-Tetraiodothyronine (thyroxine)

<400> 155
Asn Ile Phe Glu Xaa Gln Val Asp Ala Gln Pro Leu 
1               5                   10          


<210> 156
<211> 22
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> 3, 5, 3', 5'-Tetraiodothyronine (thyroxine)

<400> 156
Tyr Ser Leu Glu His Ser Thr Asp Asp Xaa Ala Ser Phe Ser Arg Ala 
1               5                   10                  15      


Leu Glu Asn Ala Thr Arg 
            20          


<210> 157
<211> 20
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (10)..(10)
<223> 3, 5, 3', 5'-Tetraiodothyronine (thyroxine)

<400> 157
Arg Ala Leu Glu Asn Ala Thr Arg Asp Xaa Phe Ile Ile Cys Pro Ile 
1               5                   10                  15      


Ile Asp Met Ala 
            20  


<210> 158
<211> 14
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (12)..(12)
<223> 3, 5, 3', 5'-Tetraiodothyronine (thyroxine)

<400> 158
Leu Leu Ser Leu Gln Glu Pro Gly Ser Lys Thr Xaa Ser Lys 
1               5                   10                  


<210> 159
<211> 16
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (7)..(7)
<223> 3, 5, 3', 5'-Tetraiodothyronine (thyroxine)

<400> 159
Glu His Ser Thr Asp Asp Xaa Ala Ser Phe Ser Arg Ala Leu Glu Asn 
1               5                   10                  15      


<210> 160
<211> 14
<212> PRT
<213> Homo sapiens

<400> 160
Leu Lys Lys Arg Gly Ile Leu Ser Pro Ala Gln Leu Leu Ser 
1               5                   10                  


<210> 161
<211> 16
<212> PRT
<213> Homo sapiens

<400> 161
Ser Gly Val Ile Ala Arg Ala Ala Glu Ile Met Glu Thr Ser Ile Gln 
1               5                   10                  15      


<210> 162
<211> 14
<212> PRT
<213> Homo sapiens

<400> 162
Pro Pro Val Arg Glu Val Thr Arg His Val Ile Gln Val Ser 
1               5                   10                  


<210> 163
<211> 15
<212> PRT
<213> Homo sapiens

<400> 163
Pro Arg Gln Gln Met Asn Gly Leu Thr Ser Phe Leu Asp Ala Ser 
1               5                   10                  15  


<210> 164
<211> 15
<212> PRT
<213> Homo sapiens

<400> 164
Leu Thr Ala Leu His Thr Leu Trp Leu Arg Glu His Asn Arg Leu 
1               5                   10                  15  


<210> 165
<211> 15
<212> PRT
<213> Homo sapiens

<400> 165
His Asn Arg Leu Ala Ala Ala Leu Lys Ala Leu Asn Ala His Trp 
1               5                   10                  15  


<210> 166
<211> 14
<212> PRT
<213> Homo sapiens

<400> 166
Ala Arg Lys Val Val Gly Ala Leu His Gln Ile Ile Thr Leu 
1               5                   10                  


<210> 167
<211> 16
<212> PRT
<213> Homo sapiens

<400> 167
Leu Pro Gly Leu Trp Leu His Gln Ala Phe Phe Ser Pro Trp Thr Leu 
1               5                   10                  15      


<210> 168
<211> 17
<212> PRT
<213> Homo sapiens

<400> 168
Met Asn Glu Glu Leu Thr Glu Arg Leu Phe Val Leu Ser Asn Ser Ser 
1               5                   10                  15      


Thr 
    


<210> 169
<211> 11
<212> PRT
<213> Homo sapiens

<400> 169
Leu Asp Leu Ala Ser Ile Asn Leu Gln Arg Gly 
1               5                   10      


<210> 170
<211> 16
<212> PRT
<213> Homo sapiens

<400> 170
Arg Ser Val Ala Asp Lys Ile Leu Asp Leu Tyr Lys His Pro Asp Asn 
1               5                   10                  15      


<210> 171
<211> 14
<212> PRT
<213> Homo sapiens

<400> 171
Ile Asp Val Trp Leu Gly Gly Leu Ala Glu Asn Phe Leu Pro 
1               5                   10                  


<210> 172
<211> 12
<212> PRT
<213> Homo sapiens

<400> 172
Gln Gln Gln His Glu Arg Arg Lys Gln Glu Arg Lys 
1               5                   10          


<210> 173
<211> 14
<212> PRT
<213> Homo sapiens

<400> 173
Pro Thr Lys Glu Ile Glu Ile Gln Val Asp Trp Asn Ser Glu 
1               5                   10                  


<210> 174
<211> 780
<212> PRT
<213> Homo sapiens

<400> 174
Met Ala Ala Pro Gly Gly Arg Ser Glu Pro Pro Gln Leu Pro Glu Tyr 
1               5                   10                  15      


Ser Cys Ser Tyr Met Val Ser Arg Pro Val Tyr Ser Glu Leu Ala Phe 
            20                  25                  30          


Gln Gln Gln His Glu Arg Arg Leu Gln Glu Arg Lys Thr Leu Arg Glu 
        35                  40                  45              


Ser Leu Ala Lys Cys Cys Ser Cys Ser Arg Lys Arg Ala Phe Gly Val 
    50                  55                  60                  


Leu Lys Thr Leu Val Pro Ile Leu Glu Trp Leu Pro Lys Tyr Arg Val 
65                  70                  75                  80  


Lys Glu Trp Leu Leu Ser Asp Val Ile Ser Gly Val Ser Thr Gly Leu 
                85                  90                  95      


Val Ala Thr Leu Gln Gly Met Ala Tyr Ala Leu Leu Ala Ala Val Pro 
            100                 105                 110         


Val Gly Tyr Gly Leu Tyr Ser Ala Phe Phe Pro Ile Leu Thr Tyr Phe 
        115                 120                 125             


Ile Phe Gly Thr Ser Arg His Ile Ser Val Gly Pro Phe Pro Val Val 
    130                 135                 140                 


Ser Leu Met Val Gly Ser Val Val Leu Ser Met Ala Pro Asp Glu His 
145                 150                 155                 160 


Phe Leu Val Ser Ser Ser Asn Gly Thr Val Leu Asn Thr Thr Met Ile 
                165                 170                 175     


Asp Thr Ala Ala Arg Asp Thr Ala Arg Val Leu Ile Ala Ser Ala Leu 
            180                 185                 190         


Thr Leu Leu Val Gly Ile Ile Gln Leu Ile Phe Gly Gly Leu Gln Ile 
        195                 200                 205             


Gly Phe Ile Val Arg Tyr Leu Ala Asp Pro Leu Val Gly Gly Phe Thr 
    210                 215                 220                 


Thr Ala Ala Ala Phe Gln Val Leu Val Ser Gln Leu Lys Ile Val Leu 
225                 230                 235                 240 


Asn Val Ser Thr Lys Asn Tyr Asn Gly Val Leu Ser Ile Ile Tyr Thr 
                245                 250                 255     


Leu Val Glu Ile Phe Gln Asn Ile Gly Asp Thr Asn Leu Ala Asp Phe 
            260                 265                 270         


Thr Ala Gly Leu Leu Thr Ile Val Val Cys Met Ala Val Lys Glu Leu 
        275                 280                 285             


Asn Asp Arg Phe Arg His Lys Ile Pro Val Pro Ile Pro Ile Glu Val 
    290                 295                 300                 


Ile Val Thr Ile Ile Ala Thr Ala Ile Ser Tyr Gly Ala Asn Leu Glu 
305                 310                 315                 320 


Lys Asn Tyr Asn Ala Gly Ile Val Lys Ser Ile Pro Arg Gly Phe Leu 
                325                 330                 335     


Pro Pro Glu Leu Pro Pro Val Ser Leu Phe Ser Glu Met Leu Ala Ala 
            340                 345                 350         


Ser Phe Ser Ile Ala Val Val Ala Tyr Ala Ile Ala Val Ser Val Gly 
        355                 360                 365             


Lys Val Tyr Ala Thr Lys Tyr Asp Tyr Thr Ile Asp Gly Asn Gln Glu 
    370                 375                 380                 


Phe Ile Ala Phe Gly Ile Ser Asn Ile Phe Ser Gly Phe Phe Ser Cys 
385                 390                 395                 400 


Phe Val Ala Thr Thr Ala Leu Ser Arg Thr Ala Val Gln Glu Ser Thr 
                405                 410                 415     


Gly Gly Lys Thr Gln Val Ala Gly Ile Ile Ser Ala Ala Ile Val Met 
            420                 425                 430         


Ile Ala Ile Leu Ala Leu Gly Lys Leu Leu Glu Pro Leu Gln Lys Ser 
        435                 440                 445             


Val Leu Ala Ala Val Val Ile Ala Asn Leu Lys Gly Met Phe Met Gln 
    450                 455                 460                 


Leu Cys Asp Ile Pro Arg Leu Trp Arg Gln Asn Lys Ile Asp Ala Val 
465                 470                 475                 480 


Ile Trp Val Phe Thr Cys Ile Val Ser Ile Ile Leu Gly Leu Asp Leu 
                485                 490                 495     


Gly Leu Leu Ala Gly Leu Ile Phe Gly Leu Leu Thr Val Val Leu Arg 
            500                 505                 510         


Val Gln Phe Pro Ser Trp Asn Gly Leu Gly Ser Ile Pro Ser Thr Asp 
        515                 520                 525             


Ile Tyr Lys Ser Thr Lys Asn Tyr Lys Asn Ile Glu Glu Pro Gln Gly 
    530                 535                 540                 


Val Lys Ile Leu Arg Phe Ser Ser Pro Ile Phe Tyr Gly Asn Val Asp 
545                 550                 555                 560 


Gly Phe Lys Lys Cys Ile Lys Ser Thr Val Gly Phe Asp Ala Ile Arg 
                565                 570                 575     


Val Tyr Asn Lys Arg Leu Lys Ala Leu Arg Lys Ile Gln Lys Leu Ile 
            580                 585                 590         


Lys Ser Gly Gln Leu Arg Ala Thr Lys Asn Gly Ile Ile Ser Asp Ala 
        595                 600                 605             


Val Ser Thr Asn Asn Ala Phe Glu Pro Asp Glu Asp Ile Glu Asp Leu 
    610                 615                 620                 


Glu Glu Leu Asp Ile Pro Thr Lys Glu Ile Glu Ile Gln Val Asp Trp 
625                 630                 635                 640 


Asn Ser Glu Leu Pro Val Lys Val Asn Val Pro Lys Val Pro Ile His 
                645                 650                 655     


Ser Leu Val Leu Asp Cys Gly Ala Ile Ser Phe Leu Asp Val Val Gly 
            660                 665                 670         


Val Arg Ser Leu Arg Val Ile Val Lys Glu Phe Gln Arg Ile Asp Val 
        675                 680                 685             


Asn Val Tyr Phe Ala Ser Leu Gln Asp Tyr Val Ile Glu Lys Leu Glu 
    690                 695                 700                 


Gln Cys Gly Phe Phe Asp Asp Asn Ile Arg Lys Asp Thr Phe Phe Leu 
705                 710                 715                 720 


Thr Val His Asp Ala Ile Leu Tyr Leu Gln Asn Gln Val Lys Ser Gln 
                725                 730                 735     


Glu Gly Gln Gly Ser Ile Leu Glu Thr Ile Thr Leu Ile Gln Asp Cys 
            740                 745                 750         


Lys Asp Thr Leu Glu Leu Ile Glu Thr Glu Leu Thr Glu Glu Glu Leu 
        755                 760                 765             


Asp Val Gln Asp Glu Ala Met Arg Thr Leu Ala Ser 
    770                 775                 780 


<210> 175
<211> 457
<212> PRT
<213> Homo sapiens

<400> 175
Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile 
225                 230                 235                 240 


Pro Cys Leu Leu Phe Ser Phe Leu Thr Gly Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Thr Asp Ser Gly Glu Lys Met Thr Leu Ser Ile Ser Val Leu Leu Ser 
            260                 265                 270         


Leu Thr Val Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Thr Ser 
        275                 280                 285             


Ser Ala Val Pro Leu Ile Gly Lys Tyr Met Leu Phe Thr Met Val Phe 
    290                 295                 300                 


Val Ile Ala Ser Ile Ile Ile Thr Val Ile Val Ile Asn Thr His His 
305                 310                 315                 320 


Arg Ser Pro Ser Thr His Val Met Pro Asn Trp Val Arg Lys Val Phe 
                325                 330                 335     


Ile Asp Thr Ile Pro Asn Ile Met Phe Phe Ser Thr Met Lys Arg Pro 
            340                 345                 350         


Ser Arg Glu Lys Gln Asp Lys Lys Ile Phe Thr Glu Asp Ile Asp Ile 
        355                 360                 365             


Ser Asp Ile Ser Gly Lys Pro Gly Pro Pro Pro Met Gly Phe His Ser 
    370                 375                 380                 


Pro Leu Ile Lys His Pro Glu Val Lys Ser Ala Ile Glu Gly Ile Lys 
385                 390                 395                 400 


Tyr Ile Ala Glu Thr Met Lys Ser Asp Gln Glu Ser Asn Asn Ala Ala 
                405                 410                 415     


Ala Glu Trp Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly 
            420                 425                 430         


Val Phe Met Leu Val Cys Ile Ile Gly Thr Leu Ala Val Phe Ala Gly 
        435                 440                 445             


Arg Leu Ile Glu Leu Asn Gln Gln Gly 
    450                 455         


<210> 176
<211> 403
<212> PRT
<213> Homo sapiens

<400> 176
Leu Val Ala Lys Leu Phe Lys Asp Tyr Ser Ser Val Val Arg Pro Val 
1               5                   10                  15      


Glu Asp His Arg Gln Val Val Glu Val Thr Val Gly Leu Gln Leu Ile 
            20                  25                  30          


Gln Leu Ile Asn Val Asp Glu Val Asn Gln Ile Val Thr Thr Asn Val 
        35                  40                  45              


Arg Leu Lys Gln Gln Trp Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp 
    50                  55                  60                  


Asp Tyr Gly Gly Val Lys Lys Ile His Ile Pro Ser Glu Lys Ile Trp 
65                  70                  75                  80  


Arg Pro Asp Leu Val Leu Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile 
                85                  90                  95      


Val Lys Phe Thr Lys Val Leu Leu Gln Tyr Thr Gly His Ile Thr Trp 
            100                 105                 110         


Thr Pro Pro Ala Ile Phe Lys Ser Tyr Cys Glu Ile Ile Val Thr His 
        115                 120                 125             


Phe Pro Phe Asp Glu Gln Asn Cys Ser Met Lys Leu Gly Thr Trp Thr 
    130                 135                 140                 


Tyr Asp Gly Ser Val Val Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp 
145                 150                 155                 160 


Leu Ser Asn Phe Met Glu Ser Gly Glu Trp Val Ile Lys Glu Ser Arg 
                165                 170                 175     


Gly Trp Lys His Ser Val Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr 
            180                 185                 190         


Leu Asp Ile Thr Tyr His Phe Val Met Gln Arg Leu Pro Leu Tyr Phe 
        195                 200                 205             


Ile Val Asn Val Ile Ile Pro Cys Leu Leu Phe Ser Phe Leu Thr Gly 
    210                 215                 220                 


Leu Val Phe Tyr Leu Pro Thr Asp Ser Gly Glu Lys Met Thr Leu Ser 
225                 230                 235                 240 


Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu Val Ile Val Glu 
                245                 250                 255     


Leu Ile Pro Ser Thr Ser Ser Ala Val Pro Leu Ile Gly Lys Tyr Met 
            260                 265                 270         


Leu Phe Thr Met Val Phe Val Ile Ala Ser Ile Ile Ile Thr Val Ile 
        275                 280                 285             


Val Ile Asn Thr His His Arg Ser Pro Ser Thr His Val Met Pro Asn 
    290                 295                 300                 


Trp Val Arg Lys Val Phe Ile Asp Thr Ile Pro Asn Ile Met Phe Phe 
305                 310                 315                 320 


Ser Thr Met Lys Arg Pro Ser Arg Glu Lys Gln Asp Lys Lys Ile Phe 
                325                 330                 335     


Thr Glu Asp Ile Asp Ile Ser Asp Ile Ser Gly Lys Pro Gly Pro Pro 
            340                 345                 350         


Pro Met Gly Phe His Ser Pro Leu Ile Lys His Pro Glu Val Lys Ser 
        355                 360                 365             


Ala Ile Glu Gly Ile Lys Tyr Ile Ala Glu Thr Met Lys Ser Asp Gln 
    370                 375                 380                 


Glu Ser Asn Asn Ala Ala Ala Glu Trp Lys Tyr Val Ala Met Val Met 
385                 390                 395                 400 


Asp His Ile 
            


<210> 177
<211> 8
<212> PRT
<213> Homo sapiens

<400> 177
Glu Ile Ile Val Thr His Phe Pro 
1               5               


<210> 178
<211> 30
<212> PRT
<213> Homo sapiens

<400> 178
Trp Thr Pro Pro Ala Ile Phe Lys Ser Tyr Cys Glu Ile Ile Val Thr 
1               5                   10                  15      


His Phe Pro Phe Asp Glu Gln Asn Cys Ser Met Lys Leu Gly 
            20                  25                  30  


<210> 179
<211> 15
<212> PRT
<213> Homo sapiens

<400> 179
Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln Asn Cys Ser 
1               5                   10                  15  


<210> 180
<211> 14
<212> PRT
<213> Homo sapiens

<400> 180
Ile Phe Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro 
1               5                   10                  


<210> 181
<211> 181
<212> PRT
<213> Homo sapiens

<400> 181
Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu 
            180     


<210> 182
<211> 437
<212> PRT
<213> Homo sapiens

<400> 182
Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile 
225                 230                 235                 240 


Pro Cys Leu Leu Phe Ser Phe Leu Thr Gly Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Thr Asp Ser Gly Glu Lys Met Thr Leu Ser Ile Ser Val Leu Leu Ser 
            260                 265                 270         


Leu Thr Val Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Thr Ser 
        275                 280                 285             


Ser Ala Val Pro Leu Ile Gly Lys Tyr Met Leu Phe Thr Met Val Phe 
    290                 295                 300                 


Val Ile Ala Ser Ile Ile Ile Thr Val Ile Val Ile Asn Thr His His 
305                 310                 315                 320 


Arg Ser Pro Ser Thr His Val Met Pro Asn Trp Val Arg Lys Val Phe 
                325                 330                 335     


Ile Asp Thr Ile Pro Asn Ile Met Phe Phe Ser Thr Met Lys Arg Pro 
            340                 345                 350         


Ser Arg Glu Lys Gln Asp Lys Lys Ile Phe Thr Glu Asp Ile Asp Ile 
        355                 360                 365             


Ser Asp Ile Ser Gly Lys Pro Gly Pro Pro Pro Met Gly Phe His Ser 
    370                 375                 380                 


Pro Leu Ile Lys His Pro Glu Val Lys Ser Ala Ile Glu Gly Ile Lys 
385                 390                 395                 400 


Tyr Ile Ala Glu Thr Met Lys Ser Asp Gln Glu Ser Asn Asn Ala Ala 
                405                 410                 415     


Ala Glu Trp Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly 
            420                 425                 430         


Val Phe Met Leu Val 
        435         


<210> 183
<211> 20
<212> PRT
<213> Homo sapiens

<400> 183
Val Gln His Ala Pro Leu Glu Met Gly Pro Gln Pro Arg Ala Glu Ala 
1               5                   10                  15      


Thr Trp Gln Phe 
            20  


<210> 184
<211> 20
<212> PRT
<213> Homo sapiens

<400> 184
Gly Phe Leu Gly Glu Leu Thr Ser Ser Glu Val Ala Thr Glu Val Pro 
1               5                   10                  15      


Phe Arg Leu Met 
            20  


<210> 185
<211> 20
<212> PRT
<213> Homo sapiens

<400> 185
Val Ala Thr Glu Val Pro Phe Arg Leu Met His Pro Gln Pro Glu Asp 
1               5                   10                  15      


Pro Ala Lys Glu 
            20  


<210> 186
<211> 20
<212> PRT
<213> Homo sapiens

<400> 186
Tyr Leu Leu Thr Ser His Arg Thr Ala Thr Ala Ala Glu Glu Phe Ala 
1               5                   10                  15      


Phe Leu Met Gln 
            20  


<210> 187
<211> 17
<212> PRT
<213> Gallus gallus

<400> 187
Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 
1               5                   10                  15      


Arg 
    


<210> 188
<211> 15
<212> PRT
<213> Pulex irritans

<400> 188
Gly Pro Asp Trp Lys Val Ser Lys Glu Cys Lys Asp Pro Asn Asn 
1               5                   10                  15  


<210> 189
<211> 15
<212> PRT
<213> Pulex irritans

<400> 189
Gln Glu Lys Glu Lys Cys Met Lys Phe Cys Lys Lys Val Cys Lys 
1               5                   10                  15  


<210> 190
<211> 5
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Gln or Arg

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Lys or Arg

<400> 190
Xaa Xaa Arg Ala Ala 
1               5   


<210>  191
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  191

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly 
1               5                   10                  15  

<210>  192
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 

