                         SEQUENCE LISTING

<110>  Bioanalytica SA
       Sidera, Katerina
       Mamalaki, Avgi
       Patsavoudi, Evangelia
 
<120>  COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA

<130>  M/52402-PCT

<150>  US 61/386,764
<151>  2010-09-27

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  645
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence encoding mAb 4C5

<400>  1
gagctcgtca tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattaat agctatttaa gctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcaacag cctggagtat      240

gaagatatgg gaatttatta ttgtctacag tatgatgagt ttcctcggct cacgttcggt      300

gctgggacca ggctggagct gaaacgggct gatgctgcac caactgtatc catcttccca      360

ccatccagtg agcagttaac atctggaggt gcctcagtcg tgtgcttctt gaacaacttc      420

tatatcaaag acatcaatgt caagtggaag attgatggca gtgaacgaca aaatggcgtc      480

ctgaacagtt ggactgatca ggacagcaaa gacagcacct acagcatgag cagcaccctc      540

acgttgacca aggacgagta tgaacgacat aacagctata cctgtgaggc cactcacaag      600

acatcaactt cacccattgt caagagcttc aacaggaatg agtgt                      645


<210>  2
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of mAb 4C5

<400>  2

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Arg 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys Arg Ala Asp Ala 
            100                 105                 110         


Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser 
        115                 120                 125             


Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Ile Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val 
145                 150                 155                 160 


Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser 
            180                 185                 190         


Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys 
        195                 200                 205             


Ser Phe Asn Arg Asn Glu Cys 
    210                 215 


<210>  3
<211>  645
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence of chimeric 4C5

<400>  3
gagctcgtca tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattaat agctatttaa gctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcaacag cctggagtat      240

gaagatatgg gaatttatta ttgtctacag tatgatgagt ttcctcggct cacgttcggt      300

gctgggacca ggctggagct gaaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctgggact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagtt cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  4
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of chimeric 4C5

<400>  4

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Arg 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  5
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of CDR1 of 4C5

<400>  5

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  6
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of CDR2 of 4C5

<400>  6

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  7
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of CDR3 of 4C5

<400>  7

Leu Gln Tyr Asp Glu Phe Pro Arg Leu Thr 
1               5                   10  


