                         SEQUENCE LISTING

<110>  NEOGENIX ONCOLOGY, INC.
       Wang, XuePing
 
<120>  Colon and Pancreas Cancer Peptidomimetics

<130>  77685.008202

<140>  Unassigned
<141>  2011-09-23

<150>  61/385,587
<151>  2010-09-23

<150>  61/407,112
<151>  2010-10-27

<150>  61/435,163
<151>  2011-01-21

<150>  61/435,176
<151>  2011-01-21

<150>  61/467,896
<151>  2011-03-25

<150>  PCT/US2011/41502
<151>  2011-06-22

<160>  89    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 Peptidomimetic


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa may be Leu

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa may be Glu or Asp

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa may be Tyr or Trp

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa may be Thr or Ile

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa may be Gln or Tyr

<400>  1

Ser Xaa Pro Xaa Asp Xaa Phe Arg Tyr Xaa Asn Xaa 
1               5                   10          


<210>  2
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa may be Leu

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa may be Glu or Asp

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa may be Tyr or Trp

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa may be Thr or Ile

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa may be Gln or Tyr

<400>  2

Ser Xaa Pro Xaa Asp Xaa Phe Arg Tyr Xaa Asn Xaa Lys 
1               5                   10              


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa may be Glu or Asp

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa may be Trp or Tyr

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa may be Thr or Ile

<400>  3

Ser Leu Glu Pro Glu Xaa Asp Trp Xaa Phe Arg Tyr Xaa Asn Tyr 
1               5                   10                  15  


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  4

Phe Pro Glu Asp Tyr Phe Arg Tyr Thr Asn Gln Lys 
1               5                   10          


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  5

Ser Leu Pro Asp Asp Trp Phe Arg Tyr Ile Asn Tyr 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic


<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa may be any amino acid

<400>  6

Ser Phe Pro Val Asn Cys Cys Arg Tyr Lys Lys Xaa 
1               5                   10          


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  7

Ser Phe Pro Val Asn Cys Cys Arg Tyr Lys Lys 
1               5                   10      


<210>  8
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  8

Phe Leu Glu Val Tyr Ile Arg Lys Val Ile Arg Arg Val Glu Val Gln 
1               5                   10                  15      


Arg Asn Phe Asp Arg Cys Leu Ala Glu Ser His Thr Arg 
            20                  25                  


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  9

Ala Glu Thr Val Glu Ser Cys Leu Ala Lys Ser His Thr Glu Asn Ser 
1               5                   10                  15      


Phe Thr Asn Val 
            20  


<210>  10
<211>  16
<212>  PRT
<213>  Ariticial Sequence

<400>  10

Ala Glu Thr Val Glu Ser Cys Leu Ala Lys Ser His Thr Glu Asn Ser 
1               5                   10                  15      


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  11

Trp His Thr Leu Pro Glu Lys Ser Leu Asp Glu Asn 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  12

Trp His Thr Leu Pro Glu Ser Gly Glu Val Thr Ser 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  13

Glu Tyr Gly Leu Gln Gln Gly Thr Pro Asn Ser Lys 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  14

Phe Pro Ala Ile Met Ser Arg Thr Pro Ala Ala Thr 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  15

Val His Ala Ile Glu Asp Asn Trp Ser Pro Arg Gly 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  16

Glu Ala Ser Lys Ser Ser His Thr Leu Trp Thr Asp 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  17

Ser Gln Lys Pro Thr His Ile Gln Lys Ala Leu Ser 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  18

Phe Asn Asp Gly Gly Ala Leu Ser Ser Leu Arg Arg 
1               5                   10          


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  19

Tyr Ser His Ser Phe Pro Glu Asp Tyr Phe Arg Tyr Thr Asn Gln Lys 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  20

Tyr Ser His Ser Ser Leu Pro Asp Asp Trp Phe Arg Tyr Ile Asn Tyr 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  21

Tyr Ser His Ser Trp His Thr Leu Pro Glu Lys Ser Leu Asp Glu Asn 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  22

Tyr Ser His Ser Trp His Thr Leu Pro Glu Ser Gly Glu Val Thr Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  23

Tyr Ser His Ser Val His Ala Ile Glu Asp Asn Trp Ser Pro Arg Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  24
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 epitope peptidomimetic

<400>  24

Ser Leu Pro Asp Asp Trp Phe Arg Tyr Ile Asn Tyr Ser Leu Pro Asp 
1               5                   10                  15      


Asp Trp Phe Arg Tyr Ile Asn Tyr 
            20                  


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M13 N-terminal sequence

<400>  25

Tyr Ser His Ser 
1               


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M13 C-terminal sequence

<400>  26

Gly Gly Gly Ser 
1               


<210>  27
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC thermolysin fragment

<400>  27

Leu Val Thr Thr Ser Thr Thr Ser Thr Pro Gln Thr Ser Thr Thr Ser 
1               5                   10                  15      


Ala Pro Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser 
            20                  25                  30          


Ala Pro Thr Thr Ser Thr Thr Ser Thr Pro Gln Thr Ser 
        35                  40                  45  


<210>  28
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC thermolysin fragment

<400>  28

Ser Ser Pro Thr Thr Ser Thr Thr Pro Thr Pro Gln Thr Ser Thr Thr 
1               5                   10                  15      


Ser Ser Pro Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr 
            20                  25                  30          


Ser Ala Pro Thr Thr Ser Thr Thr Ser Thr Pro Gln Thr Ser 
        35                  40                  45      


<210>  29
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC thermolysin fragment

<400>  29

Ile Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser 
1               5                   10                  15      


Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser 
            20                  25                  30          


Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Thr Pro Thr Ser Ser 
        35                  40                  45              


Thr Thr Ser Thr Pro Gln Thr Ser Thr Thr Ser 
    50                  55                  


<210>  30
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC thermolysin fragment

<400>  30

Ala Ser Ile Pro Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser 
1               5                   10                  15      


Ala Pro Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser 
            20                  25                  30          


Thr Pro Gln Thr Thr Thr Ser Ser Ala Pro Thr Ser Ser Thr Thr Ser 
        35                  40                  45              


Ala Pro Thr Thr Ser Thr 
    50                  


<210>  31
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC thermolysin fragment

<400>  31

Met Thr Ser Gly Pro Gly Thr Thr Pro Ser Pro Val Pro Thr Thr Ser 
1               5                   10                  15      


Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Gly Pro Gly Thr Thr 
            20                  25                  30          


Pro Ser Pro Val Pro Thr Thr Ser Thr Thr Ser Ala Pro 
        35                  40                  45  


<210>  32
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC thermolysin fragment

<400>  32

Ile Thr Ser Met Pro Ser Gly Pro Gly Thr Thr Pro Ser Pro Val Pro 
1               5                   10                  15      


Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Gly Pro 
            20                  25                  30          


Gly Thr Thr Pro Ser Pro Val Pro Thr Thr Ser Thr Thr Ser Ala Pro 
        35                  40                  45              


Thr Thr Ser Thr Thr Ser 
    50                  


<210>  33
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC thermolysin fragment

<400>  33

Leu Ser Pro Val Pro Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser 
1               5                   10                  15      


Thr Thr Ser Gly Pro Gly Thr Thr Pro Ser Pro Val Pro Thr Thr Ser 
            20                  25                  30          


Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Gly Pro Gly Thr Thr 
        35                  40                  45              


Pro Ser Pro Val Pro Thr Thr Ser Thr Thr Pro 
    50                  55                  


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC thermolysin consensus peptide

<400>  34

Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Ala Pro 
1               5                   10                  15      


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC NPC-1 epitope identified by deletion studies

<400>  35

Gly Cys Pro Val Thr Ser Thr Pro Val Thr Ala Pro Ser Thr Pro 
1               5                   10                  15  


<210>  36
<211>  5030
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Val Gly Arg Arg Lys Leu Ala Leu Leu Trp Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Cys Thr Arg His Thr Gly His Ala Gln Asp Gly Ser Ser 
            20                  25                  30          


Glu Ser Ser Tyr Lys His His Pro Ala Leu Ser Pro Ile Ala Arg Gly 
        35                  40                  45              


Pro Ser Gly Val Pro Leu Arg Gly Ala Thr Val Phe Pro Ser Leu Arg 
    50                  55                  60                  


Thr Ile Pro Val Val Arg Ala Ser Asn Pro Ala His Asn Gly Arg Val 
65                  70                  75                  80  


Cys Ser Thr Trp Gly Ser Phe His Tyr Lys Thr Phe Asp Gly Asp Val 
                85                  90                  95      


Phe Arg Phe Pro Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Gly 
            100                 105                 110         


Ala Ala Tyr Glu Asp Phe Asn Ile Gln Leu Arg Arg Ser Gln Glu Ser 
        115                 120                 125             


Ala Ala Pro Thr Leu Ser Arg Val Leu Met Lys Val Asp Gly Val Val 
    130                 135                 140                 


Ile Gln Leu Thr Lys Gly Ser Val Leu Val Asn Gly His Pro Val Leu 
145                 150                 155                 160 


Leu Pro Phe Ser Gln Ser Gly Val Leu Ile Gln Gln Ser Ser Ser Tyr 
                165                 170                 175     


Thr Lys Val Glu Ala Arg Leu Gly Leu Val Leu Met Trp Asn His Asp 
            180                 185                 190         


Asp Ser Leu Leu Leu Glu Leu Asp Thr Lys Tyr Ala Asn Lys Thr Cys 
        195                 200                 205             


Gly Leu Cys Gly Asp Phe Asn Gly Met Pro Val Val Ser Glu Leu Leu 
    210                 215                 220                 


Ser His Asn Thr Lys Leu Thr Pro Met Glu Phe Gly Asn Leu Gln Lys 
225                 230                 235                 240 


Met Asp Asp Pro Thr Glu Gln Cys Gln Asp Pro Val Pro Glu Pro Pro 
                245                 250                 255     


Arg Asn Cys Ser Thr Gly Phe Gly Ile Cys Glu Glu Leu Leu His Gly 
            260                 265                 270         


Gln Leu Phe Ser Gly Cys Val Ala Leu Val Asp Val Gly Ser Tyr Leu 
        275                 280                 285             


Glu Ala Cys Arg Gln Asp Leu Cys Phe Cys Glu Asp Thr Asp Leu Leu 
    290                 295                 300                 


Ser Cys Val Cys His Thr Leu Ala Glu Tyr Ser Arg Gln Cys Thr His 
305                 310                 315                 320 


Ala Gly Gly Leu Pro Gln Asp Trp Arg Gly Pro Asp Phe Cys Pro Gln 
                325                 330                 335     


Lys Cys Pro Asn Asn Met Gln Tyr His Glu Cys Arg Ser Pro Cys Ala 
            340                 345                 350         


Asp Thr Cys Ser Asn Gln Glu His Ser Arg Ala Cys Glu Asp His Cys 
        355                 360                 365             


Val Ala Gly Cys Phe Cys Pro Glu Gly Thr Val Leu Asp Asp Ile Gly 
    370                 375                 380                 


Gln Thr Gly Cys Val Pro Val Ser Lys Cys Ala Cys Val Tyr Asn Gly 
385                 390                 395                 400 


Ala Ala Tyr Ala Pro Gly Ala Thr Tyr Ser Thr Asp Cys Thr Asn Cys 
                405                 410                 415     


Thr Cys Ser Gly Gly Arg Trp Ser Cys Gln Glu Val Pro Cys Pro Asp 
            420                 425                 430         


Thr Cys Ser Val Leu Gly Gly Ala His Phe Ser Thr Phe Asp Gly Lys 
        435                 440                 445             


Gln Tyr Thr Val His Gly Asp Cys Ser Tyr Val Leu Thr Lys Pro Cys 
    450                 455                 460                 


Asp Ser Ser Ala Phe Thr Val Leu Ala Glu Leu Arg Arg Cys Gly Leu 
465                 470                 475                 480 


Thr Asp Ser Glu Thr Cys Leu Lys Ser Val Thr Leu Ser Leu Asp Gly 
                485                 490                 495     


Ala Gln Thr Val Val Val Ile Lys Ala Ser Gly Glu Val Phe Leu Asn 
            500                 505                 510         


Gln Ile Tyr Thr Gln Leu Pro Ile Ser Ala Ala Asn Val Thr Ile Phe 
        515                 520                 525             


Arg Pro Ser Thr Phe Phe Ile Ile Ala Gln Thr Ser Leu Gly Leu Gln 
    530                 535                 540                 


Leu Asn Leu Gln Pro Val Pro Thr Met Gln Leu Phe Met Gln Leu Ala 
545                 550                 555                 560 


Pro Lys Leu Arg Gly Gln Thr Cys Gly Leu Cys Gly Asn Phe Asn Ser 
                565                 570                 575     


Ile Gln Ala Asp Asp Phe Arg Thr Leu Ser Gly Val Val Glu Ala Thr 
            580                 585                 590         


Ala Ala Ala Phe Phe Asn Thr Phe Lys Thr Gln Ala Ala Cys Pro Asn 
        595                 600                 605             


Ile Arg Asn Ser Phe Glu Asp Pro Cys Ser Leu Ser Val Glu Asn Glu 
    610                 615                 620                 


Lys Tyr Ala Gln His Trp Cys Ser Gln Leu Thr Asp Ala Asp Gly Pro 
625                 630                 635                 640 


Phe Gly Arg Cys His Ala Ala Val Lys Pro Gly Thr Tyr Tyr Ser Asn 
                645                 650                 655     


Cys Val Phe Asp Thr Cys Asn Cys Glu Arg Ser Glu Asp Cys Leu Cys 
            660                 665                 670         


Ala Ala Leu Ser Ser Tyr Val His Ala Cys Ala Ala Lys Gly Val Gln 
        675                 680                 685             


Leu Gly Gly Trp Arg Asp Gly Val Cys Thr Lys Pro Met Thr Thr Cys 
    690                 695                 700                 


Pro Lys Ser Met Thr Tyr His Tyr His Val Ser Thr Cys Gln Pro Thr 
705                 710                 715                 720 


Cys Arg Ser Leu Ser Glu Gly Asp Ile Thr Cys Ser Val Gly Phe Ile 
                725                 730                 735     


Pro Val Asp Gly Cys Ile Cys Pro Lys Gly Thr Phe Leu Asp Asp Thr 
            740                 745                 750         


Gly Lys Cys Val Gln Ala Ser Asn Cys Pro Cys Tyr His Arg Gly Ser 
        755                 760                 765             


Met Ile Pro Asn Gly Glu Ser Val His Asp Ser Gly Ala Ile Cys Thr 
    770                 775                 780                 


Cys Thr His Gly Lys Leu Ser Cys Ile Gly Gly Gln Ala Pro Ala Pro 
785                 790                 795                 800 


Val Cys Ala Ala Pro Met Val Phe Phe Asp Cys Arg Asn Ala Thr Pro 
                805                 810                 815     


Gly Asp Thr Gly Ala Gly Cys Gln Lys Ser Cys His Thr Leu Asp Met 
            820                 825                 830         


Thr Cys Tyr Ser Pro Gln Cys Val Pro Gly Cys Val Cys Pro Asp Gly 
        835                 840                 845             


Leu Val Ala Asp Gly Glu Gly Gly Cys Ile Thr Ala Glu Asp Cys Pro 
    850                 855                 860                 


Cys Val His Asn Glu Ala Ser Tyr Arg Ala Gly Gln Thr Ile Arg Val 
865                 870                 875                 880 


Gly Cys Asn Thr Cys Thr Cys Asp Ser Arg Met Trp Arg Cys Thr Asp 
                885                 890                 895     


Asp Pro Cys Leu Ala Thr Cys Ala Val Tyr Gly Asp Gly His Tyr Leu 
            900                 905                 910         


Thr Phe Asp Gly Gln Ser Tyr Ser Phe Asn Gly Asp Cys Glu Tyr Thr 
        915                 920                 925             


Leu Val Gln Asn His Cys Gly Gly Lys Asp Ser Thr Gln Asp Ser Phe 
    930                 935                 940                 


Arg Val Val Thr Glu Asn Val Pro Cys Gly Thr Thr Gly Thr Thr Cys 
945                 950                 955                 960 


Ser Lys Ala Ile Lys Ile Phe Leu Gly Gly Phe Glu Leu Lys Leu Ser 
                965                 970                 975     


His Gly Lys Val Glu Val Ile Gly Thr Asp Glu Ser Gln Glu Val Pro 
            980                 985                 990         


Tyr Thr Ile Gln Gln Met Gly Ile  Tyr Leu Val Val Asp  Thr Asp Ile 
        995                 1000                 1005             


Gly Leu  Val Leu Leu Trp Asp  Lys Lys Thr Ser Ile  Phe Ile Asn 
    1010                 1015                 1020             


Leu Ser  Pro Glu Phe Lys Gly  Arg Val Cys Gly Leu  Cys Gly Asn 
    1025                 1030                 1035             


Phe Asp  Asp Ile Ala Val Asn  Asp Phe Ala Thr Arg  Ser Arg Ser 
    1040                 1045                 1050             


Val Val  Gly Asp Val Leu Glu  Phe Gly Asn Ser Trp  Lys Leu Ser 
    1055                 1060                 1065             


Pro Ser  Cys Pro Asp Ala Leu  Ala Pro Lys Asp Pro  Cys Thr Ala 
    1070                 1075                 1080             


Asn Pro  Phe Arg Lys Ser Trp  Ala Gln Lys Gln Cys  Ser Ile Leu 
    1085                 1090                 1095             


His Gly  Pro Thr Phe Ala Ala  Cys His Ala His Val  Glu Pro Ala 
    1100                 1105                 1110             


Arg Tyr  Tyr Glu Ala Cys Val  Asn Asp Ala Cys Ala  Cys Asp Ser 
    1115                 1120                 1125             


Gly Gly  Asp Cys Glu Cys Phe  Cys Thr Ala Val Ala  Ala Tyr Ala 
    1130                 1135                 1140             


Gln Ala  Cys His Glu Val Gly  Leu Cys Val Cys Leu  Arg Thr Pro 
    1145                 1150                 1155             


Ser Ile  Cys Pro Leu Phe Cys  Asp Tyr Tyr Asn Pro  Glu Gly Gln 
    1160                 1165                 1170             


Cys Glu  Trp His Tyr Gln Pro  Cys Gly Val Pro Cys  Leu Arg Thr 
    1175                 1180                 1185             


Cys Arg  Asn Pro Arg Gly Asp  Cys Leu Arg Asp Val  Arg Gly Leu 
    1190                 1195                 1200             


Glu Gly  Cys Tyr Pro Lys Cys  Pro Pro Glu Ala Pro  Ile Phe Asp 
    1205                 1210                 1215             


Glu Asp  Lys Met Gln Cys Val  Ala Thr Cys Pro Thr  Pro Pro Leu 
    1220                 1225                 1230             


Pro Pro  Arg Cys His Val His  Gly Lys Ser Tyr Arg  Pro Gly Ala 
    1235                 1240                 1245             


Val Val  Pro Ser Asp Lys Asn  Cys Gln Ser Cys Leu  Cys Thr Glu 
    1250                 1255                 1260             


Arg Gly  Val Glu Cys Thr Tyr  Lys Ala Glu Ala Cys  Val Cys Thr 
    1265                 1270                 1275             


Tyr Asn  Gly Gln Arg Phe His  Pro Gly Asp Val Ile  Tyr His Thr 
    1280                 1285                 1290             


Thr Asp  Gly Thr Gly Gly Cys  Ile Ser Ala Arg Cys  Gly Ala Asn 
    1295                 1300                 1305             


Gly Thr  Ile Glu Arg Arg Val  Tyr Pro Cys Ser Pro  Thr Thr Pro 
    1310                 1315                 1320             


Val Pro  Pro Thr Thr Phe Ser  Phe Ser Thr Pro Pro  Leu Val Val 
    1325                 1330                 1335             


Ser Ser  Thr His Thr Pro Ser  Asn Gly Pro Ser Ser  Ala His Thr 
    1340                 1345                 1350             


Gly Pro  Pro Ser Ser Ala Trp  Pro Thr Thr Ala Gly  Thr Ser Pro 
    1355                 1360                 1365             


Arg Thr  Arg Leu Pro Thr Ala  Ser Ala Ser Leu Pro  Pro Val Cys 
    1370                 1375                 1380             


Gly Glu  Lys Cys Leu Trp Ser  Pro Trp Met Asp Val  Ser Arg Pro 
    1385                 1390                 1395             


Gly Arg  Gly Thr Asp Ser Gly  Asp Phe Asp Thr Leu  Glu Asn Leu 
    1400                 1405                 1410             


Arg Ala  His Gly Tyr Arg Val  Cys Glu Ser Pro Arg  Ser Val Glu 
    1415                 1420                 1425             


Cys Arg  Ala Glu Asp Ala Pro  Gly Val Pro Leu Arg  Ala Leu Gly 
    1430                 1435                 1440             


Gln Arg  Val Gln Cys Ser Pro  Asp Val Gly Leu Thr  Cys Arg Asn 
    1445                 1450                 1455             


Arg Glu  Gln Ala Ser Gly Leu  Cys Tyr Asn Tyr Gln  Ile Arg Val 
    1460                 1465                 1470             


Gln Cys  Cys Thr Pro Leu Pro  Cys Ser Thr Ser Ser  Ser Pro Ala 
    1475                 1480                 1485             


Gln Thr  Thr Pro Pro Thr Thr  Ser Lys Thr Thr Glu  Thr Arg Ala 
    1490                 1495                 1500             


Ser Gly  Ser Ser Ala Pro Ser  Ser Thr Pro Gly Thr  Val Ser Leu 
    1505                 1510                 1515             


Ser Thr  Ala Arg Thr Thr Pro  Ala Pro Gly Thr Ala  Thr Ser Val 
    1520                 1525                 1530             


Lys Lys  Thr Phe Ser Thr Pro  Ser Pro Pro Pro Val  Pro Ala Thr 
    1535                 1540                 1545             


Ser Thr  Ser Ser Met Ser Thr  Thr Ala Pro Gly Thr  Ser Val Val 
    1550                 1555                 1560             


Ser Ser  Lys Pro Thr Pro Thr  Glu Pro Ser Thr Ser  Ser Cys Leu 
    1565                 1570                 1575             


Gln Glu  Leu Cys Thr Trp Thr  Glu Trp Ile Asp Gly  Ser Tyr Pro 
    1580                 1585                 1590             


Ala Pro  Gly Ile Asn Gly Gly  Asp Phe Asp Thr Phe  Gln Asn Leu 
    1595                 1600                 1605             


Arg Asp  Glu Gly Tyr Thr Phe  Cys Glu Ser Pro Arg  Ser Val Gln 
    1610                 1615                 1620             


Cys Arg  Ala Glu Ser Phe Pro  Asn Thr Pro Leu Ala  Asp Leu Gly 
    1625                 1630                 1635             


Gln Asp  Val Ile Cys Ser His  Thr Glu Gly Leu Ile  Cys Leu Asn 
    1640                 1645                 1650             


Lys Asn  Gln Leu Pro Pro Ile  Cys Tyr Asn Tyr Glu  Ile Arg Ile 
    1655                 1660                 1665             


Gln Cys  Cys Glu Thr Val Asn  Val Cys Arg Asp Ile  Thr Arg Leu 
    1670                 1675                 1680             


Pro Lys  Thr Val Ala Thr Thr  Arg Pro Thr Pro His  Pro Thr Gly 
    1685                 1690                 1695             


Ala Gln  Thr Gln Thr Thr Phe  Thr Thr His Met Pro  Ser Ala Ser 
    1700                 1705                 1710             


Thr Glu  Gln Pro Thr Ala Thr  Ser Arg Gly Gly Pro  Thr Ala Thr 
    1715                 1720                 1725             


Ser Val  Thr Gln Gly Thr His  Thr Thr Leu Val Thr  Arg Asn Cys 
    1730                 1735                 1740             


His Pro  Arg Cys Thr Trp Thr  Lys Trp Phe Asp Val  Asp Phe Pro 
    1745                 1750                 1755             


Ser Pro  Gly Pro His Gly Gly  Asp Lys Glu Thr Tyr  Asn Asn Ile 
    1760                 1765                 1770             


Ile Arg  Ser Gly Glu Lys Ile  Cys Arg Arg Pro Glu  Glu Ile Thr 
    1775                 1780                 1785             


Arg Val  Gln Cys Arg Ala Lys  Ser His Pro Glu Val  Ser Ile Glu 
    1790                 1795                 1800             


His Leu  Gly Gln Val Val Gln  Cys Ser Arg Glu Glu  Gly Leu Val 
    1805                 1810                 1815             


Cys Arg  Asn Gln Asp Gln Gln  Gly Pro Phe Lys Met  Cys Leu Asn 
    1820                 1825                 1830             


Tyr Glu  Val Arg Val Leu Cys  Cys Glu Thr Pro Arg  Gly Cys His 
    1835                 1840                 1845             


Met Thr  Ser Thr Pro Gly Ser  Thr Ser Ser Ser Pro  Ala Gln Thr 
    1850                 1855                 1860             


Thr Pro  Ser Thr Thr Ser Lys  Thr Thr Glu Ile Gln  Ala Ser Gly 
    1865                 1870                 1875             


Ser Ser  Ala Pro Ser Ser Thr  Pro Gly Thr Val Ser  Leu Ser Thr 
    1880                 1885                 1890             


Ala Arg  Thr Thr Pro Ala Pro  Gly Thr Ala Thr Ser  Val Lys Lys 
    1895                 1900                 1905             


Thr Phe  Ser Thr Pro Ser Pro  Pro Pro Val Pro Ala  Thr Ser Thr 
    1910                 1915                 1920             


Ser Ser  Met Ser Thr Thr Ala  Pro Gly Thr Ser Val  Val Ser Ser 
    1925                 1930                 1935             


Lys Pro  Thr Pro Thr Glu Pro  Ser Thr Ser Ser Cys  Leu Gln Glu 
    1940                 1945                 1950             


Leu Cys  Thr Trp Thr Glu Trp  Ile Asp Gly Ser Tyr  Pro Ala Pro 
    1955                 1960                 1965             


Gly Ile  Asn Gly Gly Asp Phe  Asp Thr Phe Gln Asn  Leu Arg Asp 
    1970                 1975                 1980             


Glu Gly  Tyr Thr Phe Cys Glu  Ser Pro Arg Ser Val  Gln Cys Arg 
    1985                 1990                 1995             


Ala Glu  Ser Phe Pro Asn Thr  Pro Leu Gly Arg Leu  Gly Gln Asp 
    2000                 2005                 2010             


Val Ile  Cys Ser His Thr Glu  Gly Leu Ile Cys Leu  Asn Lys Asn 
    2015                 2020                 2025             


Gln Leu  Pro Pro Ile Cys Tyr  Asn Tyr Glu Ile Arg  Ile Gln Cys 
    2030                 2035                 2040             


Cys Glu  Thr Val Asn Val Cys  Arg Asp Ile Thr Arg  Pro Pro Lys 
    2045                 2050                 2055             


Thr Val  Ala Thr Thr Arg Pro  Thr Pro His Pro Thr  Gly Ala Gln 
    2060                 2065                 2070             


Thr Gln  Thr Thr Phe Thr Thr  His Met Pro Ser Ala  Ser Thr Glu 
    2075                 2080                 2085             


Gln Pro  Thr Ala Thr Ser Arg  Gly Gly Pro Thr Ala  Thr Ser Val 
    2090                 2095                 2100             


Thr Gln  Gly Thr His Thr Thr  Pro Val Thr Arg Asn  Cys His Pro 
    2105                 2110                 2115             


Arg Cys  Thr Trp Thr Thr Trp  Phe Asp Val Asp Phe  Pro Ser Pro 
    2120                 2125                 2130             


Gly Pro  His Gly Gly Asp Lys  Glu Thr Tyr Asn Asn  Ile Ile Arg 
    2135                 2140                 2145             


Ser Gly  Glu Lys Ile Cys Arg  Arg Pro Glu Glu Ile  Thr Arg Leu 
    2150                 2155                 2160             


Gln Cys  Arg Ala Lys Ser His  Pro Glu Val Ser Ile  Glu His Leu 
    2165                 2170                 2175             


Gly Gln  Val Val Gln Cys Ser  Arg Glu Glu Gly Leu  Val Cys Arg 
    2180                 2185                 2190             


Asn Gln  Asp Gln Gln Gly Pro  Phe Lys Met Cys Leu  Asn Ile Glu 
    2195                 2200                 2205             


Val Arg  Val Leu Cys Cys Glu  Thr Pro Lys Gly Cys  Pro Val Thr 
    2210                 2215                 2220             


Ser Thr  Pro Val Thr Ala Pro  Ser Thr Pro Ser Gly  Arg Ala Ile 
    2225                 2230                 2235             


Ser Pro  Thr Gln Ser Thr Ser  Ser Trp Gln Lys Ser  Arg Thr Thr 
    2240                 2245                 2250             


Thr Leu  Val Thr Thr Ser Thr  Thr Ser Thr Pro Gln  Thr Ser Thr 
    2255                 2260                 2265             


Thr Tyr  Ala His Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Ala Arg 
    2270                 2275                 2280             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Val  Pro Thr Thr 
    2285                 2290                 2295             


Ser Thr  Ile Ser Gly Pro Lys  Thr Thr Pro Ser Pro  Val Pro Thr 
    2300                 2305                 2310             


Thr Ser  Thr Thr Ser Ala Ala  Thr Thr Ser Thr Ile  Ser Ala Pro 
    2315                 2320                 2325             


Thr Thr  Ser Thr Thr Ser Val  Pro Gly Thr Thr Pro  Ser Pro Val 
    2330                 2335                 2340             


Leu Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Arg  Thr Thr Ser 
    2345                 2350                 2355             


Ala Ser  Pro Ala Gly Thr Thr  Ser Gly Pro Gly Asn  Thr Pro Ser 
    2360                 2365                 2370             


Pro Val  Pro Thr Thr Ser Thr  Ile Ser Ala Pro Thr  Thr Ser Ile 
    2375                 2380                 2385             


Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Ser Ser 
    2390                 2395                 2400             


Thr Thr  Ser Gly Pro Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr 
    2405                 2410                 2415             


Ser Ile  Thr Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    2420                 2425                 2430             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Pro 
    2435                 2440                 2445             


Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr Ser Thr  Thr Ser Thr 
    2450                 2455                 2460             


Pro Thr  Ser Ser Thr Thr Ser  Thr Pro Gln Thr Ser  Thr Thr Ser 
    2465                 2470                 2475             


Ala Ser  Thr Thr Ser Ile Thr  Ser Gly Pro Gly Thr  Thr Pro Ser 
    2480                 2485                 2490             


Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr 
    2495                 2500                 2505             


Thr Ser  Ala Ala Thr Thr Ser  Thr Ile Ser Ala Pro  Thr Thr Ser 
    2510                 2515                 2520             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Ala  Ser Thr Ala 
    2525                 2530                 2535             


Ser Lys  Thr Ser Gly Leu Gly  Thr Thr Pro Ser Pro  Ile Pro Thr 
    2540                 2545                 2550             


Thr Ser  Thr Thr Ser Pro Pro  Thr Thr Ser Thr Thr  Ser Ala Ser 
    2555                 2560                 2565             


Thr Ala  Ser Lys Thr Ser Gly  Pro Gly Thr Thr Pro  Ser Pro Val 
    2570                 2575                 2580             


Pro Thr  Thr Ser Thr Ile Phe  Ala Pro Arg Thr Ser  Thr Thr Ser 
    2585                 2590                 2595             


Ala Ser  Thr Thr Ser Thr Thr  Pro Gly Pro Gly Thr  Thr Pro Ser 
    2600                 2605                 2610             


Pro Val  Pro Thr Thr Ser Thr  Ala Ser Val Ser Lys  Thr Ser Thr 
    2615                 2620                 2625             


Ser His  Val Ser Ile Ser Lys  Thr Thr His Ser Gln  Pro Val Thr 
    2630                 2635                 2640             


Arg Asp  Cys His Leu Arg Cys  Thr Trp Thr Lys Trp  Phe Asp Val 
    2645                 2650                 2655             


Asp Phe  Pro Ser Pro Gly Pro  His Gly Gly Asp Lys  Glu Thr Tyr 
    2660                 2665                 2670             


Asn Asn  Ile Ile Arg Ser Gly  Glu Lys Ile Cys Arg  Arg Pro Glu 
    2675                 2680                 2685             


Glu Ile  Thr Arg Leu Gln Cys  Arg Ala Glu Ser His  Pro Glu Val 
    2690                 2695                 2700             


Ser Ile  Glu His Leu Gly Gln  Val Val Gln Cys Ser  Arg Glu Glu 
    2705                 2710                 2715             


Gly Leu  Val Cys Arg Asn Gln  Asp Gln Gln Gly Pro  Phe Lys Met 
    2720                 2725                 2730             


Cys Leu  Asn Tyr Glu Val Arg  Val Leu Cys Cys Glu  Thr Pro Lys 
    2735                 2740                 2745             


Gly Cys  Pro Val Thr Ser Thr  Pro Val Thr Ala Pro  Ser Thr Pro 
    2750                 2755                 2760             


Ser Gly  Arg Ala Thr Ser Pro  Thr Gln Ser Thr Ser  Ser Trp Gln 
    2765                 2770                 2775             


Lys Ser  Arg Thr Thr Thr Leu  Val Thr Thr Ser Thr  Thr Ser Thr 
    2780                 2785                 2790             


Pro Gln  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    2795                 2800                 2805             


Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr 
    2810                 2815                 2820             


Ser Thr  Pro Gln Thr Ser Ile  Ser Ser Ala Pro Thr  Ser Ser Thr 
    2825                 2830                 2835             


Thr Ser  Ala Pro Thr Ser Ser  Thr Ile Ser Ala Arg  Thr Thr Ser 
    2840                 2845                 2850             


Ile Ile  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Ser  Pro Thr Thr 
    2855                 2860                 2865             


Ser Thr  Thr Ser Ala Thr Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    2870                 2875                 2880             


Ser Ser  Thr Thr Ser Thr Pro  Gln Thr Ser Lys Thr  Ser Ala Ala 
    2885                 2890                 2895             


Thr Ser  Ser Thr Thr Ser Ser  Ser Gly Thr Thr Pro  Ser Pro Val 
    2900                 2905                 2910             


Thr Thr  Thr Ser Thr Ala Ser  Val Ser Lys Thr Ser  Thr Ser His 
    2915                 2920                 2925             


Val Ser  Val Ser Lys Thr Thr  His Ser Gln Pro Val  Thr Arg Asp 
    2930                 2935                 2940             


Cys His  Pro Arg Cys Thr Trp  Thr Lys Trp Phe Asp  Val Asp Phe 
    2945                 2950                 2955             


Pro Ser  Pro Gly Pro His Gly  Gly Asp Lys Glu Thr  Tyr Asn Asn 
    2960                 2965                 2970             


Ile Ile  Arg Ser Gly Glu Lys  Ile Cys Arg Arg Pro  Gln Glu Ile 
    2975                 2980                 2985             


Thr Arg  Leu Gln Cys Arg Ala  Lys Ser His Pro Glu  Val Ser Ile 
    2990                 2995                 3000             


Glu His  Leu Gly Gln Val Val  Gln Cys Ser Arg Glu  Glu Gly Leu 
    3005                 3010                 3015             


Val Cys  Arg Asn Gln Asp Gln  Gln Gly Pro Phe Lys  Met Cys Leu 
    3020                 3025                 3030             


Asn Tyr  Glu Val Arg Val Leu  Cys Cys Glu Thr Pro  Lys Gly Cys 
    3035                 3040                 3045             


Pro Val  Thr Ser Thr Ser Val  Thr Ala Pro Ser Pro  Leu Val Gly 
    3050                 3055                 3060             


Glu Pro  Pro Ala Gln Thr Gln  Ser Thr Ser Ser Trp  Gln Lys Ser 
    3065                 3070                 3075             


Arg Thr  Thr Thr Leu Val Thr  Ser Ser Ile Thr Ser  Thr Thr Gln 
    3080                 3085                 3090             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Pro Ala Ser 
    3095                 3100                 3105             


Ile Pro  Ser Thr Thr Ser Ala  Pro Thr Thr Ser Thr  Thr Ser Ala 
    3110                 3115                 3120             


Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    3125                 3130                 3135             


Thr Pro  Gln Thr Thr Thr Ser  Ser Ala Pro Thr Ser  Ser Thr Thr 
    3140                 3145                 3150             


Ser Ala  Pro Thr Thr Ser Thr  Ile Ser Ala Pro Thr  Thr Ser Thr 
    3155                 3160                 3165             


Ile Ser  Ala Pro Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Ala Ser 
    3170                 3175                 3180             


Thr Thr  Ser Ala Pro Thr Ser  Thr Ser Ser Ala Pro  Thr Thr Asn 
    3185                 3190                 3195             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Ala  Pro Ile Thr 
    3200                 3205                 3210             


Ser Thr  Ile Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Thr Pro Gln 
    3215                 3220                 3225             


Thr Ser  Thr Ile Ser Ser Pro  Thr Thr Ser Thr Thr  Pro Thr Pro 
    3230                 3235                 3240             


Gln Thr  Ser Thr Thr Ser Ser  Pro Thr Thr Ser Thr  Thr Ser Ala 
    3245                 3250                 3255             


Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    3260                 3265                 3270             


Thr Pro  Gln Thr Ser Ile Ser  Ser Ala Pro Thr Ser  Ser Thr Thr 
    3275                 3280                 3285             


Ser Ala  Pro Thr Ala Ser Thr  Ile Ser Ala Pro Thr  Thr Ser Thr 
    3290                 3295                 3300             


Thr Ser  Phe His Thr Thr Ser  Thr Thr Ser Pro Pro  Thr Ser Ser 
    3305                 3310                 3315             


Thr Ser  Ser Thr Pro Gln Thr  Ser Lys Thr Ser Ala  Ala Thr Ser 
    3320                 3325                 3330             


Ser Thr  Thr Ser Gly Ser Gly  Thr Thr Pro Ser Pro  Val Pro Thr 
    3335                 3340                 3345             


Thr Ser  Thr Ala Ser Val Ser  Lys Thr Ser Thr Ser  His Val Ser 
    3350                 3355                 3360             


Val Ser  Lys Thr Thr His Ser  Gln Pro Val Thr Arg  Asp Cys His 
    3365                 3370                 3375             


Pro Arg  Cys Thr Trp Thr Lys  Trp Phe Asp Val Asp  Phe Pro Ser 
    3380                 3385                 3390             


Pro Gly  Pro His Gly Gly Asp  Lys Glu Thr Tyr Asn  Asn Ile Ile 
    3395                 3400                 3405             


Arg Ser  Gly Glu Lys Ile Cys  Arg Arg Pro Glu Glu  Ile Thr Arg 
    3410                 3415                 3420             


Leu Gln  Cys Arg Ala Glu Ser  His Pro Glu Val Ser  Ile Glu His 
    3425                 3430                 3435             


Leu Gly  Gln Val Val Gln Cys  Ser Arg Glu Glu Gly  Leu Val Cys 
    3440                 3445                 3450             


Arg Asn  Gln Asp Gln Gln Gly  Pro Phe Lys Met Cys  Leu Asn Tyr 
    3455                 3460                 3465             


Glu Val  Arg Val Leu Cys Cys  Glu Thr Pro Lys Gly  Cys Pro Val 
    3470                 3475                 3480             


Thr Ser  Thr Pro Val Thr Ala  Pro Ser Thr Pro Ser  Gly Arg Ala 
    3485                 3490                 3495             


Thr Ser  Pro Thr Gln Ser Thr  Ser Ser Trp Gln Lys  Ser Arg Thr 
    3500                 3505                 3510             


Thr Thr  Leu Val Thr Thr Ser  Thr Thr Ser Thr Pro  Gln Thr Ser 
    3515                 3520                 3525             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Ile Pro Ala  Ser Thr Pro 
    3530                 3535                 3540             


Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    3545                 3550                 3555             


Thr Ser  Thr Thr Ser Ala Pro  Thr His Arg Thr Thr  Ser Gly Pro 
    3560                 3565                 3570             


Thr Thr  Ser Thr Thr Leu Ala  Pro Thr Thr Ser Thr  Thr Ser Ala 
    3575                 3580                 3585             


Pro Thr  Thr Ser Thr Asn Ser  Ala Pro Thr Thr Ser  Thr Ile Ser 
    3590                 3595                 3600             


Ala Ser  Thr Thr Ser Thr Ile  Ser Ala Pro Thr Thr  Ser Thr Ile 
    3605                 3610                 3615             


Ser Ser  Pro Thr Ser Ser Thr  Thr Ser Thr Pro Gln  Thr Ser Lys 
    3620                 3625                 3630             


Thr Ser  Ala Ala Thr Ser Ser  Thr Thr Ser Gly Ser  Gly Thr Thr 
    3635                 3640                 3645             


Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr Ser Ala  Ser Thr Thr 
    3650                 3655                 3660             


Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Gly Pro Gly 
    3665                 3670                 3675             


Thr Thr  Pro Ser Pro Val Pro  Ser Thr Ser Ile Thr  Ser Ala Ala 
    3680                 3685                 3690             


Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr Arg Thr  Thr Ser Ala 
    3695                 3700                 3705             


Pro Thr  Ser Ser Met Thr Ser  Gly Pro Gly Thr Thr  Pro Ser Pro 
    3710                 3715                 3720             


Val Pro  Thr Thr Ser Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr 
    3725                 3730                 3735             


Ser Gly  Pro Gly Thr Thr Pro  Ser Pro Val Pro Thr  Thr Ser Thr 
    3740                 3745                 3750             


Thr Ser  Ala Pro Ile Thr Ser  Thr Thr Ser Gly Pro  Gly Ser Thr 
    3755                 3760                 3765             


Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr 
    3770                 3775                 3780             


Ser Thr  Thr Ser Ala Ser Thr  Ala Ser Thr Thr Ser  Gly Pro Thr 
    3785                 3790                 3795             


Thr Ser  Thr Thr Ser Ala Ser  Thr Thr Ser Thr Ile  Ser Pro Leu 
    3800                 3805                 3810             


Thr Thr  Ser Thr Thr Ser Ala  Pro Ile Thr Ser Met  Pro Ser Gly 
    3815                 3820                 3825             


Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr Thr Ser  Thr Thr Ser 
    3830                 3835                 3840             


Ala Pro  Thr Thr Ser Thr Thr  Ser Gly Pro Gly Thr  Thr Pro Ser 
    3845                 3850                 3855             


Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr 
    3860                 3865                 3870             


Thr Ser  Ala Ser Thr Ala Ser  Thr Thr Ser Gly Pro  Gly Thr Thr 
    3875                 3880                 3885             


Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr 
    3890                 3895                 3900             


Ser Thr  Thr Ser Ala Ser Thr  Ala Ser Thr Thr Ser  Gly Pro Gly 
    3905                 3910                 3915             


Thr Ser  Leu Ser Pro Val Pro  Thr Thr Ser Thr Thr  Ser Ala Pro 
    3920                 3925                 3930             


Thr Thr  Ser Thr Thr Ser Gly  Pro Gly Thr Thr Pro  Ser Pro Val 
    3935                 3940                 3945             


Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    3950                 3955                 3960             


Gly Pro  Gly Thr Thr Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr 
    3965                 3970                 3975             


Pro Val  Ser Lys Thr Ser Thr  Ser His Leu Ser Val  Ser Lys Thr 
    3980                 3985                 3990             


Thr His  Ser Gln Pro Val Thr  Ser Asp Cys His Pro  Leu Cys Ala 
    3995                 4000                 4005             


Trp Thr  Lys Trp Phe Asp Val  Asp Phe Pro Ser Pro  Gly Pro His 
    4010                 4015                 4020             


Gly Gly  Asp Lys Glu Thr Tyr  Asn Asn Ile Ile Arg  Ser Gly Glu 
    4025                 4030                 4035             


Lys Ile  Cys Arg Arg Pro Glu  Glu Ile Thr Arg Leu  Gln Cys Arg 
    4040                 4045                 4050             


Ala Glu  Ser His Pro Glu Val  Asn Ile Glu His Leu  Gly Gln Val 
    4055                 4060                 4065             


Val Gln  Cys Ser Arg Glu Glu  Gly Leu Val Cys Arg  Asn Gln Asp 
    4070                 4075                 4080             


Gln Gln  Gly Pro Phe Lys Met  Cys Leu Asn Tyr Glu  Val Arg Val 
    4085                 4090                 4095             


Leu Cys  Cys Glu Thr Pro Arg  Gly Cys Pro Val Thr  Ser Val Thr 
    4100                 4105                 4110             


Pro Tyr  Gly Thr Ser Pro Thr  Asn Ala Leu Tyr Pro  Ser Leu Ser 
    4115                 4120                 4125             


Thr Ser  Met Val Ser Ala Ser  Val Ala Ser Thr Ser  Val Ala Ser 
    4130                 4135                 4140             


Ser Ser  Val Ala Ser Ser Ser  Val Ala Tyr Ser Thr  Gln Thr Cys 
    4145                 4150                 4155             


Phe Cys  Asn Val Ala Asp Arg  Leu Tyr Pro Ala Gly  Ser Thr Ile 
    4160                 4165                 4170             


Tyr Arg  His Arg Asp Leu Ala  Gly His Cys Tyr Tyr  Ala Leu Cys 
    4175                 4180                 4185             


Ser Gln  Asp Cys Gln Val Val  Arg Gly Val Asp Ser  Asp Cys Pro 
    4190                 4195                 4200             


Ser Thr  Thr Leu Pro Pro Ala  Pro Ala Thr Ser Pro  Ser Ile Ser 
    4205                 4210                 4215             


Thr Ser  Glu Pro Val Thr Glu  Leu Gly Cys Pro Asn  Ala Val Pro 
    4220                 4225                 4230             


Pro Arg  Lys Lys Gly Glu Thr  Trp Ala Thr Pro Asn  Cys Ser Glu 
    4235                 4240                 4245             


Ala Thr  Cys Glu Gly Asn Asn  Val Ile Ser Leu Ser  Pro Arg Thr 
    4250                 4255                 4260             


Cys Pro  Arg Val Glu Lys Pro  Thr Cys Ala Asn Gly  Tyr Pro Ala 
    4265                 4270                 4275             


Val Lys  Val Ala Asp Gln Asp  Gly Cys Cys His His  Tyr Gln Cys 
    4280                 4285                 4290             


Gln Cys  Val Cys Ser Gly Trp  Gly Asp Pro His Tyr  Ile Thr Phe 
    4295                 4300                 4305             


Asp Gly  Thr Tyr Tyr Thr Phe  Leu Asp Asn Cys Thr  Tyr Val Leu 
    4310                 4315                 4320             


Val Gln  Gln Ile Val Pro Val  Tyr Gly His Phe Arg  Val Leu Val 
    4325                 4330                 4335             


Asp Asn  Tyr Phe Cys Gly Ala  Glu Asp Gly Leu Ser  Cys Pro Arg 
    4340                 4345                 4350             


Ser Ile  Ile Leu Glu Tyr His  Gln Asp Arg Val Val  Leu Thr Arg 
    4355                 4360                 4365             


Lys Pro  Val His Gly Val Met  Thr Asn Glu Ile Ile  Phe Asn Asn 
    4370                 4375                 4380             


Lys Val  Val Ser Pro Gly Phe  Arg Lys Asn Gly Ile  Val Val Ser 
    4385                 4390                 4395             


Arg Ile  Gly Val Lys Met Tyr  Ala Thr Ile Pro Glu  Leu Gly Val 
    4400                 4405                 4410             


Gln Val  Met Phe Ser Gly Leu  Ile Phe Ser Val Glu  Val Pro Phe 
    4415                 4420                 4425             


Ser Lys  Phe Ala Asn Asn Thr  Glu Gly Gln Cys Gly  Thr Cys Thr 
    4430                 4435                 4440             


Asn Asp  Arg Lys Asp Glu Cys  Arg Thr Pro Arg Gly  Thr Val Val 
    4445                 4450                 4455             


Ala Ser  Cys Ser Glu Met Ser  Gly Leu Trp Asn Val  Ser Ile Pro 
    4460                 4465                 4470             


Asp Gln  Pro Ala Cys His Arg  Pro His Pro Thr Pro  Thr Thr Val 
    4475                 4480                 4485             


Gly Pro  Thr Thr Val Gly Ser  Thr Thr Val Gly Pro  Thr Thr Val 
    4490                 4495                 4500             


Gly Ser  Thr Thr Val Gly Pro  Thr Thr Pro Pro Ala  Pro Cys Leu 
    4505                 4510                 4515             


Pro Ser  Pro Ile Cys His Leu  Ile Leu Ser Lys Val  Phe Glu Pro 
    4520                 4525                 4530             


Cys His  Thr Val Ile Pro Pro  Leu Leu Phe Tyr Glu  Gly Cys Val 
    4535                 4540                 4545             


Phe Asp  Arg Cys His Met Thr  Asp Leu Asp Val Val  Cys Ser Ser 
    4550                 4555                 4560             


Leu Glu  Leu Tyr Ala Ala Leu  Cys Ala Ser His Asp  Ile Cys Ile 
    4565                 4570                 4575             


Asp Trp  Arg Gly Arg Thr Gly  His Met Cys Pro Phe  Thr Cys Pro 
    4580                 4585                 4590             


Ala Asp  Lys Val Tyr Gln Pro  Cys Gly Pro Ser Asn  Pro Ser Tyr 
    4595                 4600                 4605             


Cys Tyr  Gly Asn Asp Ser Ala  Ser Leu Gly Ala Leu  Arg Glu Ala 
    4610                 4615                 4620             


Gly Pro  Ile Thr Glu Gly Cys  Phe Cys Pro Glu Gly  Met Thr Leu 
    4625                 4630                 4635             


Phe Ser  Thr Ser Ala Gln Val  Cys Val Pro Thr Gly  Cys Pro Arg 
    4640                 4645                 4650             


Cys Leu  Gly Pro His Gly Glu  Pro Val Lys Val Gly  His Thr Val 
    4655                 4660                 4665             


Gly Met  Asp Cys Gln Glu Cys  Thr Cys Glu Ala Ala  Thr Trp Thr 
    4670                 4675                 4680             


Leu Thr  Cys Arg Pro Lys Leu  Cys Pro Leu Pro Pro  Ala Cys Pro 
    4685                 4690                 4695             


Leu Pro  Gly Phe Val Pro Val  Pro Ala Ala Pro Gln  Ala Gly Gln 
    4700                 4705                 4710             


Cys Cys  Pro Gln Tyr Ser Cys  Ala Cys Asn Thr Ser  Arg Cys Pro 
    4715                 4720                 4725             


Ala Pro  Val Gly Cys Pro Glu  Gly Ala Arg Ala Ile  Pro Thr Tyr 
    4730                 4735                 4740             


Gln Glu  Gly Ala Cys Cys Pro  Val Gln Asn Cys Ser  Trp Thr Val 
    4745                 4750                 4755             


Cys Ser  Ile Asn Gly Thr Leu  Tyr Gln Pro Gly Ala  Val Val Ser 
    4760                 4765                 4770             


Ser Ser  Leu Cys Glu Thr Cys  Arg Cys Glu Leu Pro  Gly Gly Pro 
    4775                 4780                 4785             


Pro Ser  Asp Ala Phe Val Val  Ser Cys Glu Thr Gln  Ile Cys Asn 
    4790                 4795                 4800             


Thr His  Cys Pro Val Gly Phe  Glu Tyr Gln Glu Gln  Ser Gly Gln 
    4805                 4810                 4815             


Cys Cys  Gly Thr Cys Val Gln  Val Ala Cys Val Thr  Asn Thr Ser 
    4820                 4825                 4830             


Lys Ser  Pro Ala His Leu Phe  Tyr Pro Gly Glu Thr  Trp Ser Asp 
    4835                 4840                 4845             


Ala Gly  Asn His Cys Val Thr  His Gln Cys Glu Lys  His Gln Asp 
    4850                 4855                 4860             


Gly Leu  Val Val Val Thr Thr  Lys Lys Ala Cys Pro  Pro Leu Ser 
    4865                 4870                 4875             


Cys Ser  Leu Asp Glu Ala Arg  Met Ser Lys Asp Gly  Cys Cys Arg 
    4880                 4885                 4890             


Phe Cys  Pro Leu Pro Pro Pro  Pro Tyr Gln Asn Gln  Ser Thr Cys 
    4895                 4900                 4905             


Ala Val  Tyr His Arg Ser Leu  Ile Ile Gln Gln Gln  Gly Cys Ser 
    4910                 4915                 4920             


Ser Ser  Glu Pro Val Arg Leu  Ala Tyr Cys Arg Gly  Asn Cys Gly 
    4925                 4930                 4935             


Asp Ser  Ser Ser Met Tyr Ser  Leu Glu Gly Asn Thr  Val Glu His 
    4940                 4945                 4950             


Arg Cys  Gln Cys Cys Gln Glu  Leu Arg Thr Ser Leu  Arg Asn Val 
    4955                 4960                 4965             


Thr Leu  His Cys Thr Asp Gly  Ser Ser Arg Ala Phe  Ser Tyr Thr 
    4970                 4975                 4980             


Glu Val  Glu Glu Cys Gly Cys  Met Gly Arg Arg Cys  Pro Ala Pro 
    4985                 4990                 4995             


Gly Asp  Thr Gln His Ser Glu  Glu Ala Glu Pro Glu  Pro Ser Gln 
    5000                 5005                 5010             


Glu Ala  Glu Ser Gly Ser Trp  Glu Arg Gly Val Pro  Val Ser Pro 
    5015                 5020                 5025             


Met His  
    5030 


<210>  37
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Cys Cys Ala Cys Cys Cys Ala Thr Thr Cys Thr Cys Ala Ala Cys 
1               5                   10                  15      


Cys Thr Gly Thr Thr Ala Cys Thr Cys Gly Thr Gly Ala Thr Thr Gly 
            20                  25                  30          


Thr Cys Ala Thr Cys Thr Gly Cys Gly Thr Thr Gly Cys Ala Cys Cys 
        35                  40                  45              


Thr Gly Gly Ala Cys Thr Ala Ala Ala Thr Gly Gly Thr Thr Cys Gly 
    50                  55                  60                  


Ala Cys Gly Thr Thr Gly Ala Cys Thr Thr Cys Cys Cys Gly Thr Cys 
65                  70                  75                  80  


Cys Cys Cys Ala Gly Gly Thr Cys Cys Ala Cys Ala Cys Gly Gly Thr 
                85                  90                  95      


Gly Gly Thr Gly Ala Cys Ala Ala Gly Gly Ala Ala Ala Cys Cys Thr 
            100                 105                 110         


Ala Thr Ala Ala Cys Ala Ala Cys Ala Thr Cys Ala Thr Thr Cys Gly 
        115                 120                 125             


Thr Thr Cys Cys Gly Gly Thr Gly Ala Gly Ala Ala Ala Ala Thr Cys 
    130                 135                 140                 


Thr Gly Cys Cys Gly Thr Cys Gly Thr Cys Cys Gly Gly Ala Gly Gly 
145                 150                 155                 160 


Ala Ala Ala Thr Cys Ala Cys Cys Cys Gly Thr Cys Thr Gly Cys Ala 
                165                 170                 175     


Gly Thr Gly Cys Cys Gly Thr Gly Cys Ala Gly Ala Gly Thr Cys Cys 
            180                 185                 190         


Cys Ala Cys Cys Cys Gly Gly Ala Gly Gly Thr Ala Thr Cys Thr Ala 
        195                 200                 205             


Thr Cys Gly Ala Ala Cys Ala Thr Cys Thr Gly Gly Gly Cys Cys Ala 
    210                 215                 220                 


Gly Gly Thr Thr Gly Thr Gly Cys Ala Gly Thr Gly Cys Ala Gly Cys 
225                 230                 235                 240 


Cys Gly Thr Gly Ala Ala Gly Ala Ala Gly Gly Thr Cys Thr Gly Gly 
                245                 250                 255     


Thr Thr Thr Gly Cys Cys Gly Thr Ala Ala Cys Cys Ala Ala Gly Ala 
            260                 265                 270         


Thr Cys Ala Gly Cys Ala Gly Gly Gly Cys Cys Cys Gly Thr Thr Cys 
        275                 280                 285             


Ala Ala Ala Ala Thr Gly Thr Gly Cys Cys Thr Gly Ala Ala Cys Thr 
    290                 295                 300                 


Ala Thr Gly Ala Ala Gly Thr Cys Cys Gly Thr Gly Thr Cys Cys Thr 
305                 310                 315                 320 


Gly Thr Gly Cys Thr Gly Cys Gly Ala Ala Ala Cys Cys Cys Cys Ala 
                325                 330                 335     


Ala Ala Ala Gly Gly Cys Thr Gly Thr Cys Cys Ala Gly Thr Thr Ala 
            340                 345                 350         


Cys Thr Thr Cys Thr Ala Cys Cys Cys Cys Gly Gly Thr Thr Ala Cys 
        355                 360                 365             


Cys Gly Cys Gly Cys Cys Gly Thr Cys Cys Ala Cys Thr Cys Cys Ala 
    370                 375                 380                 


Ala Gly Cys Gly Gly Cys Cys Gly Cys Gly Cys Gly Ala Cys Cys Ala 
385                 390                 395                 400 


Gly Cys Cys Cys Gly Ala Cys Cys Cys Ala Gly Ala Gly Cys Ala Cys 
                405                 410                 415     


Cys Thr Cys Cys Thr Cys Thr Thr Gly Gly Cys Ala Gly Ala Ala Ala 
            420                 425                 430         


Thr Cys Cys Cys Gly Cys Ala Cys Cys Ala Cys Thr Ala Cys Cys Cys 
        435                 440                 445             


Thr Gly Gly Thr Thr Ala Cys Thr Ala Cys Cys Thr Cys Thr Ala Cys 
    450                 455                 460                 


Thr Ala Cys Cys Thr Cys Cys Ala Cys Thr Cys Cys Ala Cys Ala Gly 
465                 470                 475                 480 


Ala Cys Thr Thr Cys Cys Ala Cys Cys Ala Cys Cys Thr Cys Cys Gly 
                485                 490                 495     


Cys Cys Cys Cys Gly Ala Cys Thr Ala Cys Cys Ala Gly Cys Ala Cys 
            500                 505                 510         


Thr Ala Cys Cys Ala Gly Cys Gly Cys Cys Cys Cys Gly Ala Cys Cys 
        515                 520                 525             


Ala Cys Thr Ala Gly Cys Ala Cys Thr Ala Cys Cys Thr Cys Cys Gly 
    530                 535                 540                 


Cys Thr Cys Cys Gly Ala Cys Cys Ala Cys Cys Thr Cys Cys Ala Cys 
545                 550                 555                 560 


Cys Ala Cys Thr Thr Cys Thr Ala Cys Cys Cys Cys Gly Cys Ala Gly 
                565                 570                 575     


Ala Cys Cys Thr Cys Thr Ala Thr Cys Thr Cys Thr Thr Cys Thr Gly 
            580                 585                 590         


Cys Gly Cys Cys Gly Ala Cys Cys Ala Gly Cys Thr Cys Thr Ala Cys 
        595                 600                 605             


Cys Ala Cys Cys Ala Gly Cys Gly Cys Thr Cys Cys Gly Ala Cys Thr 
    610                 615                 620                 


Ala Gly Cys Thr Cys Cys Ala Cys Gly Ala Thr Thr Thr Cys Thr Gly 
625                 630                 635                 640 


Cys Thr Cys Gly Thr Ala Cys Thr Ala Cys Thr Thr Cys Thr Ala Thr 
                645                 650                 655     


Cys Ala Thr Thr Thr Cys Cys Gly Cys Cys Cys Cys Thr Ala Cys Gly 
            660                 665                 670         


Ala Cys Cys Thr Cys Thr Ala Cys Cys Ala Cys Thr Thr Cys Thr Ala 
        675                 680                 685             


Gly Cys Cys Cys Thr Ala Cys Cys Ala Cys Cys Thr Cys Thr Ala Cys 
    690                 695                 700                 


Cys Ala Cys Gly Thr Cys Cys Gly Cys Gly Ala Cys Cys Ala Cys Cys 
705                 710                 715                 720 


Ala Cys Cys Thr Cys Cys Ala Cys Thr Ala Cys Cys Thr Cys Thr Gly 
                725                 730                 735     


Cys Ala Cys Cys Ala Ala Cys Thr Thr Cys Cys Thr Cys Thr Ala Cys 
            740                 745                 750         


Thr Ala Cys Gly Ala Gly Cys Ala Cys Gly Cys Cys Gly Cys Ala Gly 
        755                 760                 765             


Ala Cys Thr Thr Cys Thr Ala Ala Ala Ala Cys Cys Thr Cys Thr Gly 
    770                 775                 780                 


Cys Gly Gly Cys Ala Ala Cys Cys Thr Cys Thr Thr Cys Thr Ala Cys 
785                 790                 795                 800 


Cys Ala Cys Cys Ala Gly Cys Ala Gly Cys Thr Cys Thr Gly Gly Cys 
                805                 810                 815     


Ala Cys Cys Ala Cys Thr Cys Cys Gly Ala Gly Cys Cys Cys Gly Gly 
            820                 825                 830         


Thr Gly Ala Cys Cys Ala Cys Cys Ala Cys Thr Ala Gly Cys Ala Cys 
        835                 840                 845             


Cys Gly Cys Thr Thr Cys Thr Gly Thr Gly Thr Cys Cys Ala Ala Gly 
    850                 855                 860                 


Ala Cys Cys Ala Gly Cys Ala Cys Cys Thr Cys Thr Cys Ala Cys Gly 
865                 870                 875                 880 


Thr Gly Thr Cys Thr Gly Thr Thr Thr Cys Thr Ala Ala Ala Ala Cys 
                885                 890                 895     


Gly Ala Cys Cys Cys Ala Cys Thr Cys Cys Cys Ala Gly Cys Cys Gly 
            900                 905                 910         


Gly Thr Thr Ala Cys Cys Cys Gly Cys 
        915                 920     


<210>  38
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223> N-terminal fragment of MUC5AC (long)

<400>  38

Thr Thr His Ser Gln Pro Val Thr Arg Asp Cys His Leu Arg Cys Thr 
1               5                   10                  15      


Trp Thr Lys Trp Phe Asp Val Asp Phe Pro Ser Pro Gly Pro His Gly 
            20                  25                  30          


Gly Asp Lys Glu Thr Tyr Asn Asn Ile Ile Arg Ser Gly Glu Lys Ile 
        35                  40                  45              


Cys Arg Arg Pro Glu Glu Ile Thr Arg Leu Gln Cys Arg Ala Glu Ser 
    50                  55                  60                  


His Pro Glu Val Ser Ile Glu His Leu Gly Gln Val Val Gln Cys Ser 
65                  70                  75                  80  


Arg Glu Glu Gly Leu Val Cys Arg Asn Gln Asp Gln Gln Gly Pro Phe 
                85                  90                  95      


Lys Met Cys Leu Asn Tyr Glu Val Arg Val Leu Cys Cys Glu Thr Pro 
            100                 105                 110         


Lys Gly Cys Pro Val Thr Ser Thr Pro Val Thr Ala Pro Ser Thr Pro 
        115                 120                 125             


Ser Gly Arg Ala Thr Ser Pro Thr Gln Ser Thr Ser Ser Trp Gln Lys 
    130                 135                 140                 


Ser Arg Thr Thr Thr Leu Val Thr Thr Ser Thr Thr Ser Thr Pro Gln 
145                 150                 155                 160 


Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Ala Pro Thr 
                165                 170                 175     


Thr Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Thr Pro Gln 
            180                 185                 190         


Thr Ser Ile Ser Ser Ala Pro Thr Ser Ser Thr Thr Ser Ala Pro Thr 
        195                 200                 205             


Ser Ser Thr Ile Ser Ala Arg Thr Thr Ser Ile Ile Ser Ala Pro Thr 
    210                 215                 220                 


Thr Ser Thr Thr Ser Ser Pro Thr Thr Ser Thr Thr Ser Ala Thr Thr 
225                 230                 235                 240 


Thr Ser Thr Thr Ser Ala Pro Thr Ser Ser Thr Thr Ser Thr Pro Gln 
                245                 250                 255     


Thr Ser Lys Thr Ser Ala Ala Thr Ser Ser Thr Thr Ser Ser Ser Gly 
            260                 265                 270         


Thr Thr Pro Ser Pro Val Thr Thr Thr Ser Thr Ala Ser Val Ser Lys 
        275                 280                 285             


Thr Thr Ser His Val Ser Val Ser Lys Thr Thr His Ser Gln Pro Val 
    290                 295                 300                 


Thr Arg 
305     


<210>  39
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223> N-terminal fragment of MUC5AC (long)

<400>  39
actactcatt ctcaacctgt aactcgtgat tgtcatctgc gctgtacttg gactaaatgg       60

tttgacgtgg acttcccgtc ccctggcccg cacggtggtg ataaagaaac ctacaataac      120

atcattcgct ctggtgagaa aatctgccgt cgtccggaag aaatcactcg tctgcaatgt      180

cgtgccgaat cccacccgga ggtgagcatc gaacacctgg gtcaggttgt tcagtgttct      240

cgtgaggaag gtctggtatg ccgtaaccaa gatcagcaag gcccattcaa aatgtgcctg      300

aactacgaag ttcgtgttct gtgttgcgag actccgaaag gttgcccggt tacgagcacg      360

cctgtcaccg caccgagcac gccg                                             384


<210>  40
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal fragment of MUC5AC (short)

<400>  40

Thr Thr His Ser Gln Pro Val Thr Arg Asp Cys His Leu Arg Cys Thr 
1               5                   10                  15      


Trp Thr Lys Trp Phe Asp Val Asp Phe Pro Ser Pro Gly Pro His Gly 
            20                  25                  30          


Gly Asp Lys Glu Thr Tyr Asn Asn Ile Ile Arg Ser Gly Glu Lys Ile 
        35                  40                  45              


Cys Arg Arg Pro Glu Glu Ile Thr Arg Leu Gln Cys Arg Ala Glu Ser 
    50                  55                  60                  


His Pro Glu Val Ser Ile Glu His Leu Gly Gln Val Val Gln Cys Ser 
65                  70                  75                  80  


Arg Glu Glu Gly Leu Val Cys Arg Asn Gln Asp Gln Gln Gly Pro Phe 
                85                  90                  95      


Lys Met Cys Leu Asn Tyr Glu Val Arg Val Leu Cys Cys Glu Thr Pro 
            100                 105                 110         


Lys Gly Cys Pro Val Thr Ser Thr Pro Val Thr Ala Pro Ser Thr Pro 
        115                 120                 125             


<210>  41
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N-terminal fragment of MUC5AC (short)

<400>  41
actactcatt ctcaacctgt aactcgtgat tgtcatctgc gctgtacttg gactaaatgg       60

tttgacgtgg acttcccgtc ccctggcccg cacggtggtg ataaagaaac ctacaataac      120

atcattcgct ctggtgagaa aatctgccgt cgtccggaag aaatcactcg tctgcaatgt      180

cgtgccgaat cccacccgga ggtgagcatc gaacacctgg gtcaggttgt tcagtgttct      240

cgtgaggaag gtctggtatg ccgtaaccaa gatcagcaag gcccattcaa aatgtgcctg      300

aactacgaag ttcgtgttct gtgttgcgag actccgaaag gttgcccggt tacgagcacg      360

cctgtcaccg caccgagcac gccg                                             384


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC tandem repeat

<400>  42

Thr Thr Ser Thr Thr Ser Ala Pro 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC tandem repeat

<400>  43

Gly Ser Thr Pro Ser Pro Val Pro 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC tandem repeat

<400>  44

Thr Ala Ser Thr Thr Ser Gly Pro 
1               5               


<210>  45
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC truncation construct (85)

<400>  45

Ala Thr Met Ser Val Gly Arg Arg Lys Leu Ala Leu Leu Trp Ala Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ala Cys Thr Thr Thr His Ser Gln Pro Val Thr Arg 
            20                  25                  30          


Asp Cys His Leu Arg Cys Thr Trp Thr Lys Trp Phe Asp Val Asp Phe 
        35                  40                  45              


Pro Ser Pro Gly Pro His Gly Gly Asp Lys Glu Thr Tyr Asn Asn Ile 
    50                  55                  60                  


Ile Arg Ser Gly Glu Lys Ile Cys Arg Arg Pro Glu Glu Ile Thr Arg 
65                  70                  75                  80  


Leu Gln Cys Arg Ala 
                85  


<210>  46
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC truncation construct (136)

<400>  46

Ala Thr Met Ser Val Gly Arg Arg Lys Leu Ala Leu Leu Trp Ala Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ala Cys Thr Thr Thr His Ser Gln Pro Val Thr Arg 
            20                  25                  30          


Asp Cys His Leu Arg Cys Thr Trp Thr Lys Trp Phe Asp Val Asp Phe 
        35                  40                  45              


Pro Ser Pro Gly Pro His Gly Gly Asp Lys Glu Thr Tyr Asn Asn Ile 
    50                  55                  60                  


Ile Arg Ser Gly Glu Lys Ile Cys Arg Arg Pro Glu Glu Ile Thr Arg 
65                  70                  75                  80  


Leu Gln Cys Arg Ala Glu Ser His Pro Glu Val Ser Ile Glu His Leu 
                85                  90                  95      


Gly Gln Val Val Gln Cys Ser Arg Glu Glu Gly Leu Val Cys Arg Asn 
            100                 105                 110         


Gln Asp Gln Gln Gly Pro Phe Lys Met Cys Leu Asn Tyr Glu Val Arg 
        115                 120                 125             


Val Leu Cys Cys Glu Thr Pro Lys 
    130                 135     


<210>  47
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC truncation construct (151)

<400>  47

Ala Thr Met Ser Val Gly Arg Arg Lys Leu Ala Leu Leu Trp Ala Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ala Cys Thr Thr Thr His Ser Gln Pro Val Thr Arg 
            20                  25                  30          


Asp Cys His Leu Arg Cys Thr Trp Thr Lys Trp Phe Asp Val Asp Phe 
        35                  40                  45              


Pro Ser Pro Gly Pro His Gly Gly Asp Lys Glu Thr Tyr Asn Asn Ile 
    50                  55                  60                  


Ile Arg Ser Gly Glu Lys Ile Cys Arg Arg Pro Glu Glu Ile Thr Arg 
65                  70                  75                  80  


Leu Gln Cys Arg Ala Glu Ser His Pro Glu Val Ser Ile Glu His Leu 
                85                  90                  95      


Gly Gln Val Val Gln Cys Ser Arg Glu Glu Gly Leu Val Cys Arg Asn 
            100                 105                 110         


Gln Asp Gln Gln Gly Pro Phe Lys Met Cys Leu Asn Tyr Glu Val Arg 
        115                 120                 125             


Val Leu Cys Cys Glu Thr Pro Lys Gly Cys Pro Val Thr Ser Thr Pro 
    130                 135                 140                 


Val Thr Ala Pro Ser Thr Pro 
145                 150     


<210>  48
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC truncation construct (187)

<400>  48

Ala Thr Met Ser Val Gly Arg Arg Lys Leu Ala Leu Leu Trp Ala Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ala Cys Thr Thr Thr His Ser Gln Pro Val Thr Arg 
            20                  25                  30          


Asp Cys His Leu Arg Cys Thr Trp Thr Lys Trp Phe Asp Val Asp Phe 
        35                  40                  45              


Pro Ser Pro Gly Pro His Gly Gly Asp Lys Glu Thr Tyr Asn Asn Ile 
    50                  55                  60                  


Ile Arg Ser Gly Glu Lys Ile Cys Arg Arg Pro Glu Glu Ile Thr Arg 
65                  70                  75                  80  


Leu Gln Cys Arg Ala Glu Ser His Pro Glu Val Ser Ile Glu His Leu 
                85                  90                  95      


Gly Gln Val Val Gln Cys Ser Arg Glu Glu Gly Leu Val Cys Arg Asn 
            100                 105                 110         


Gln Asp Gln Gln Gly Pro Phe Lys Met Cys Leu Asn Tyr Glu Val Arg 
        115                 120                 125             


Val Leu Cys Cys Glu Thr Pro Lys Gly Cys Pro Val Thr Ser Thr Pro 
    130                 135                 140                 


Val Thr Ala Pro Ser Thr Pro Ser Gly Arg Ala Thr Ser Pro Thr Gln 
145                 150                 155                 160 


Ser Thr Ser Ser Trp Gln Lys Ser Arg Thr Thr Thr Leu Val Thr Thr 
                165                 170                 175     


Ser Thr Thr Ser Thr Pro Gln Thr Ser Thr Thr 
            180                 185         


<210>  49
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC truncation construct (289)

<400>  49

Ala Thr Met Ser Val Gly Arg Arg Lys Leu Ala Leu Leu Trp Ala Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ala Cys Thr Thr Thr His Ser Gln Pro Val Thr Arg 
            20                  25                  30          


Asp Cys His Leu Arg Cys Thr Trp Thr Lys Trp Phe Asp Val Asp Phe 
        35                  40                  45              


Pro Ser Pro Gly Pro His Gly Gly Asp Lys Glu Thr Tyr Asn Asn Ile 
    50                  55                  60                  


Ile Arg Ser Gly Glu Lys Ile Cys Arg Arg Pro Glu Glu Ile Thr Arg 
65                  70                  75                  80  


Leu Gln Cys Arg Ala Glu Ser His Pro Glu Val Ser Ile Glu His Leu 
                85                  90                  95      


Gly Gln Val Val Gln Cys Ser Arg Glu Glu Gly Leu Val Cys Arg Asn 
            100                 105                 110         


Gln Asp Gln Gln Gly Pro Phe Lys Met Cys Leu Asn Tyr Glu Val Arg 
        115                 120                 125             


Val Leu Cys Cys Glu Thr Pro Lys Gly Cys Pro Val Thr Ser Thr Pro 
    130                 135                 140                 


Val Thr Ala Pro Ser Thr Pro Ser Gly Arg Ala Thr Ser Pro Thr Gln 
145                 150                 155                 160 


Ser Thr Ser Ser Trp Gln Lys Ser Arg Thr Thr Thr Leu Val Thr Thr 
                165                 170                 175     


Ser Thr Thr Ser Thr Pro Gln Thr Ser Thr Thr Ser Ala Pro Thr Thr 
            180                 185                 190         


Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr 
        195                 200                 205             


Ser Thr Thr Ser Thr Pro Gln Thr Ser Ile Ser Ser Ala Pro Thr Ser 
    210                 215                 220                 


Ser Thr Thr Ser Ala Pro Thr Ser Ser Thr Ile Ser Ala Arg Thr Thr 
225                 230                 235                 240 


Ser Ile Ile Ser Ala Pro Thr Thr Ser Thr Thr Ser Ser Pro Thr Thr 
                245                 250                 255     


Ser Thr Thr Ser Ala Thr Thr Thr Ser Thr Thr Ser Ala Pro Thr Ser 
            260                 265                 270         


Ser Thr Thr Ser Thr Pro Gln Thr Ser Lys Thr Ser Ala Ala Thr Ser 
        275                 280                 285             


Ser 
    


<210>  50
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC5AC truncation construct (338)

<400>  50

Ala Thr Met Ser Val Gly Arg Arg Lys Leu Ala Leu Leu Trp Ala Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ala Cys Thr Thr Thr His Ser Gln Pro Val Thr Arg 
            20                  25                  30          


Asp Cys His Leu Arg Cys Thr Trp Thr Lys Trp Phe Asp Val Asp Phe 
        35                  40                  45              


Pro Ser Pro Gly Pro His Gly Gly Asp Lys Glu Thr Tyr Asn Asn Ile 
    50                  55                  60                  


Ile Arg Ser Gly Glu Lys Ile Cys Arg Arg Pro Glu Glu Ile Thr Arg 
65                  70                  75                  80  


Leu Gln Cys Arg Ala Glu Ser His Pro Glu Val Ser Ile Glu His Leu 
                85                  90                  95      


Gly Gln Val Val Gln Cys Ser Arg Glu Glu Gly Leu Val Cys Arg Asn 
            100                 105                 110         


Gln Asp Gln Gln Gly Pro Phe Lys Met Cys Leu Asn Tyr Glu Val Arg 
        115                 120                 125             


Val Leu Cys Cys Glu Thr Pro Lys Gly Cys Pro Val Thr Ser Thr Pro 
    130                 135                 140                 


Val Thr Ala Pro Ser Thr Pro Ser Gly Arg Ala Thr Ser Pro Thr Gln 
145                 150                 155                 160 


Ser Thr Ser Ser Trp Gln Lys Ser Arg Thr Thr Thr Leu Val Thr Thr 
                165                 170                 175     


Ser Thr Thr Ser Thr Pro Gln Thr Ser Thr Thr Ser Ala Pro Thr Thr 
            180                 185                 190         


Ser Thr Thr Ser Ala Pro Thr Thr Ser Thr Thr Ser Ala Pro Thr Thr 
        195                 200                 205             


Ser Thr Thr Ser Thr Pro Gln Thr Ser Ile Ser Ser Ala Pro Thr Ser 
    210                 215                 220                 


Ser Thr Thr Ser Ala Pro Thr Ser Ser Thr Ile Ser Ala Arg Thr Thr 
225                 230                 235                 240 


Ser Ile Ile Ser Ala Pro Thr Thr Ser Thr Thr Ser Ser Pro Thr Thr 
                245                 250                 255     


Ser Thr Thr Ser Ala Thr Thr Thr Ser Thr Thr Ser Ala Pro Thr Ser 
            260                 265                 270         


Ser Thr Thr Ser Thr Pro Gln Thr Ser Lys Thr Ser Ala Ala Thr Ser 
        275                 280                 285             


Ser Thr Thr Ser Ser Ser Gly Thr Thr Pro Ser Pro Val Thr Thr Thr 
    290                 295                 300                 


Ser Thr Ala Ser Val Ser Lys Thr Ser Thr Ser His Val Ser Val Ser 
305                 310                 315                 320 


Lys Thr Thr His Ser Gln Pro Val Thr Arg Cys Thr His His His His 
                325                 330                 335     


His His 


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA ID# s9074 (sense)

<400>  51
agaugugccu caacuacgat t                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA ID# s9074 (antisense)

<400>  52
ucguaguuga ggcacaucut g                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA ID# s9075 (sense)

<400>  53
gcucuggaac gugagcauat t                                                 21


<210>  54
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA ID# s9075 (antisense)

<400>  54
uaugcucacg uuccagagcc g                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA ID# s9076

<400>  55
gcgugcucgu cgacaacuat t                                                 21


<210>  56
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA ID# s9076 (antisense)

<400>  56
uaguugucga cgagcacgcg g                                                 21


<210>  57
<211>  965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NPC-1 antibody light chain

<400>  57
atgagaatac cattaattag ctagggacca aaattcaaag acaaaatgga ttttcaggtg       60

cagattttca gcttcctgct aatcagtgcc tcagtcatac tgtccagagg acaagttgtt      120

ctcacccagt ctccagtaat catgtctgca tctccagggg agaaggtcac catgacctgc      180

agtgccagct caagtataag ttacatgtac tggtaccagc agaagccagg cacctccccc      240

aaaagatgga tttatgacac atccaaactg gcttctggag tccctgctcg cttcagtggc      300

agtgggtctg ggacctctta ttctctcaca atcagcaaca tggaggctgg agatgctgcc      360

acttattact gccatcagcg ggattcttac ccatggacgt tcggtggagg caccaacctg      420

gaaatcaaac gggctgatgc tgcaccaact gtatccatct tcccaccatc cagtgagcag      480

ttaacatctg gaggtgcctc agtcgtgtgc ttcttgaaca acttctaccc caaagacatc      540

aatgtcaagt ggaagattga tggcagtgaa cgacaaaatg gcgtcctgaa cagttggact      600

gatcaggaca gcaaagacag cacctacagc atgagcagca ccctcacgtt gaccaaggac      660

gagtatgaac gacataacag ctatacctgt gaggccactc acaagacatc aacttcaccc      720

attgtcaaga gcttcaacag gaatgagtgt tagagacaaa ggtcctgaga cgccaccacc      780

agctccccag ctccatccta tcttcccttc taaggtcttg gaggcttccc cacaagcgac      840

ctaccactgt tgcggtgctc caaacctcct ccccacctcc ttctcctcct cctccctttc      900

cttggctttt atcatgctaa tatttgcaga aaatattcaa taaagtgagt ctttgcactt      960

gaaaa                                                                  965


<210>  58
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 antibody light chain


<220>
<221>  MISC_FEATURE
<222>  (46)..(55)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (71)..(77)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (110)..(118)
<223>  CDR3

<400>  58

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Gln Val Val Leu Thr Gln Ser Pro Val Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Ile Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Thr Ser 
    50                  55                  60                  


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Met Glu Ala Gly Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg 
            100                 105                 110         


Asp Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
        115                 120                 125             


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
                165                 170                 175     


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
        195                 200                 205             


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
    210                 215                 220                 


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235 


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 light chain CDR1

<400>  59

Ser Ala Ser Ser Ser Ile Ser Tyr Met Tyr 
1               5                   10  


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 light chain CDR2

<400>  60

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 antibody light chain CDR3

<400>  61

His Gln Arg Asp Ser Tyr Pro Trp Thr 
1               5                   


<210>  62
<211>  1520
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NPC-1 antibody heavy chain

<400>  62
ttttccatcc tcttctcata gagcctccat cagaccatgg ctgtcctggc actgctcctc       60

tgcctggtga cattcccaag ctgtgtcctg tcccaggtgc agctgaagga gtcaggacct      120

gacctggtgg cgccctcaca gagcctgtcc atcacatgca ctgtctcagg attctcatta      180

agcaaatttg gtgtaaactg ggttcgccag cctccaggaa agggtctgga gtggctggga      240

gtaatatggg gtgacgggag cacaagttat aattcaggtc tcatatcaag actgagcatc      300

agcaaggaga actccaagag ccaggttttc ttaaaactga acagtctgca agctgatgac      360

acagccacat actactgtgt caaaccgggg ggtgactact ggggtcacgg aacctcagtc      420

accgtctcct cagccaaaac gacaccccca tctgtctatc cactggcccc tggatctgct      480

gcccaaacta actccatggt gaccctggga tgcctggtca agggctattt ccctgagcca      540

gtgacagtga cctggaactc tggatccctg tccagcggtg tgcacacctt cccagctgtc      600

ctgcagtctg acctctacac tctgagcagc tcagtgactg tcccctccag cacctggccc      660

agcgagaccg tcacctgcaa cgttgcccac ccggccagca gcaccaaggt ggacaagaaa      720

attgtgccca gggattgtgg ttgtaagcct tgcatatgta cagtcccaga agtatcatct      780

gtcttcatct tccccccaaa gcccaaggat gtgctcacca ttactctgac tcctaaggtc      840

acgtgtgttg tggtagacat cagcaaggat gatcccgagg tccagttcag ctggtttgta      900

gatgtggagg tgcacacagc tcagacgcaa ccccgggagg agcagttcaa cagcactttc      960

cgctcagtca gtgaacttcc catcatgcac caggactggc tcaatggcaa ggagttcaaa     1020

tgcagggtca acagtgcagc tttccctgcc cccatcgaga aaaccatctc caaaaccaaa     1080

ggcagaccga aggctccaca ggtgtacacc attccacctc ccaaggagca gatggccaag     1140

gataaagtca gtctgacctg catgataaca gacttcttcc ctgaagacat tactgtggag     1200

tggcagtgga atgggcagcc agcggagaac tacaagaaca ctcagcccat catggacaca     1260

gatggctctt acttcgtcta cagcaagctc aatgtgcaga agagcaactg ggaggcagga     1320

aatactttca cctgctctgt gttacatgag ggcctgcaca accaccatac tgagaagagc     1380

ctctcccact ctcctggtaa atgatcccag tgtccttgga gccctctggt cctacaggac     1440

tctgacacct acctccaccc ctccctgtat aaataaagca cccagcactg ccttgggacc     1500

ctgcaaaaaa aaaaaaaaaa                                                 1520


<210>  63
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 antibody heavy chain


<220>
<221>  MISC_FEATURE
<222>  (49)..(54)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (69)..(84)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (114)..(121)
<223>  CDR3

<400>  63

Met Ala Val Leu Ala Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Asp Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Lys Phe Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Ser Tyr Asn Ser 
65                  70                  75                  80  


Gly Leu Ile Ser Arg Leu Ser Ile Ser Lys Glu Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Lys Leu Asn Ser Leu Gln Ala Asp Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Val Lys Pro Gly Gly Asp Tyr Trp Gly His Gly Thr Ser Val 
        115                 120                 125             


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
    130                 135                 140                 


Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
                165                 170                 175     


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
            180                 185                 190         


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro 
        195                 200                 205             


Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile 
225                 230                 235                 240 


Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val 
        275                 280                 285             


Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln 
    290                 295                 300                 


Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala 
                325                 330                 335     


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro 
            340                 345                 350         


Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala 
        355                 360                 365             


Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu 
    370                 375                 380                 


Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr 
385                 390                 395                 400 


Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr 
                405                 410                 415     


Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe 
            420                 425                 430         


Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys 
        435                 440                 445             


Ser Leu Ser His Ser Pro Gly Lys 
    450                 455     


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 antibody heavy chain CDR1

<400>  64

Ser Lys Phe Gly Val Asn 
1               5       


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 heavy chain CDR2

<400>  65

Val Ile Trp Gly Asp Gly Ser Thr Ser Tyr Asn Ser Gly Leu Ile Ser 
1               5                   10                  15      


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 antibody heavy chain CDR3

<400>  66

Cys Val Lys Pro Gly Gly Asp Tyr 
1               5               


<210>  67
<211>  737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NPC-1 Chi-antibody light chain

<400>  67
gcatagatct gccaccatgg actttcaggt ccagatattt agctttctat tgattagcgc       60

ctctgtcatt ctgagtaggg ggcaggtggt gctcacccag tctccagtga tcatgtcagc      120

ctcaccagga gaaaaagtga ctatgacctg ctcagcatcc tccagcatca gttacatgta      180

ctggtaccag cagaagccag gcacctcgcc caagcgttgg atctacgata cttccaagct      240

ggcaagtggg gtacccgcac gcttcagtgg aagtggctcc ggaacctcgt acagtttgac      300

catttcaaat atggaagctg gggacgcagc tacatattat tgccaccaga gagactccta      360

cccgtggacc ttcggaggcg gtactaattt agagatcaag aggaccgtag ccgctccttc      420

cgtgttcatc tttccccctt ccgacgaaca actgaaaagc ggtacagcct ccgtggtttg      480

tctgctgaac aacttctacc cccgggaggc taaagttcag tggaaggttg acaatgctct      540

gcagtcaggc aactctcaag agagcgtcac ggagcaagat agcaaagatt ctacatattc      600

tctctcttct acacttacac ttagcaaggc cgattatgag aagcacaagg tgtatgcctg      660

cgaggtgact catcagggtc tttcttctcc tgtcactaaa agcttcaacc gaggcgaatg      720

ttgatgaaga tcttacg                                                     737


<210>  68
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 chi-antibody light chain with signal peptide


<220>
<221>  SIGNAL
<222>  (1)..(22)

<220>
<221>  MISC_FEATURE
<222>  (46)..(55)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (71)..(77)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (110)..(118)
<223>  CDR3

<400>  68

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Gln Val Val Leu Thr Gln Ser Pro Val Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Ile Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Thr Ser 
    50                  55                  60                  


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Met Glu Ala Gly Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg 
            100                 105                 110         


Asp Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 chi-antibody light chain CDR1

<400>  69

Ser Ala Ser Ser Ser Ile Ser Tyr Met Tyr 
1               5                   10  


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 chi-antibody light chain CDR2

<400>  70

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 chi-antibody light chain CDR3

<400>  71

His Gln Arg Asp Ser Tyr Pro Trp Thr 
1               5                   


<210>  72
<211>  1418
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NPC-1 chi-antibody heavy chain

<400>  72
gagcggtacc gccaccatgg cagtgctggc ccttcttcta tgtctggtga ccttcccatc       60

ctgcgtcctg agccaggtac aactgaagga gtcgggccca gacctagtgg ctccgtcaca      120

atcactctcc attacgtgca ctgtctccgg cttctctttg tctaaattcg gcgtgaattg      180

ggtgcgacag ccccccggga aggggcttga gtggttagga gttatctggg gtgacggctc      240

aaccagctac aactcaggac taatctcacg cttgtcaatt tcaaaggaga attcaaagtc      300

tcaggtgttc cttaagctca actcgctgca agccgacgat accgcaacct attactgcgt      360

caaacctggc ggggactact ggggccatgg cacctccgtc acagtgagtt ccgcatccac      420

aaagggtccc agtgtttttc ctttggcgcc ctctagcaaa tcgacatctg gcggcacagc      480

cgcacttggg tgcttggtta aagactactt ccccgaaccg gtgacagtat cttggaactc      540

tggcgctctt accagcggag ttcatacctt ccctgccgta ttacagtcta gcgggcccta      600

ctccctctcc tctgtcgtga cagtcccaag ctcttctctg ggaactcaaa cctacatctg      660

caatgtgaac cataaaccta gcaacacgaa agtggacaaa aaggtcgaac ccaagagttg      720

cgacaagaca cacacctgcc ctccttgtcc tgctccagag ctcctcggcg gacctagcgt      780

tttcttgttc cctccgaaac caaaggacac cttgatgatt tctcggaccc ccgaggtgac      840

atgtgtagta gttgatgtct cccacgagga ccctgaggtc aagtttaatt ggtatgtgga      900

cggtgtggag gtccacaacg ccaaaacaaa accacgggag gaacagtaca attccacata      960

tagggtggtg agcgtcctta ccgtcctgca tcaggattgg ttaaatggta aggagtataa     1020

gtgtaaggtg tctaacaagg ctctgcctgc tcccatcgaa aaaactataa gtaaggccaa     1080

aggacagccc agggaacctc aggtgtatac tcttccaccc agtagagatg agctgactaa     1140

aaaccaggtg tccctgactt gtctggtgaa gggattttac ccatccgata tcgccgtgga     1200

atgggagtcc aacggacagc cagaaaacaa ttataaaact atgccaccag tgctggatag     1260

tgatggtagt ttttttctgt acagtaagct gactgttgat aagagtagat ggcagcaggg     1320

taatgttttt agttgtagcg ttatgcacga agctctgcac aatcactata ctcagaagag     1380

cctgagcctg agccccggta agtgatgagg taccgagc                             1418


<210>  73
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 chi-antibody heavy chain


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  73

Met Ala Val Leu Ala Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Asp Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Lys Phe Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Ser Tyr Asn Ser 
65                  70                  75                  80  


Gly Leu Ile Ser Arg Leu Ser Ile Ser Lys Glu Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Lys Leu Asn Ser Leu Gln Ala Asp Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Val Lys Pro Gly Gly Asp Tyr Trp Gly His Gly Thr Ser Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Pro Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Met Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 chi-antibody heavy chain CDR1

<400>  74

Gly Phe Ser Leu Ser Lys Phe Gly Val Asn 
1               5                   10  


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 chi-antibody heavy chain CDR2

<400>  75

Val Ile Trp Gly Asp Gly Ser Thr Ser Tyr Asn Ser Gly Leu Ile Ser 
1               5                   10                  15      


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPC-1 chi-antibody heavy chain CDR3

<400>  76

Pro Gly Gly Asp Tyr 
1               5   


<210>  77
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized NEO 103 light chain

<400>  77
aagcttgcca ccatgaagta cctgctgccc accgctgctg ctggcttgct gctgctggca       60

gctcagcctg ccatggccga gatcgtgctg acccagtctc ctggcaccct gtctctgagc      120

cctggcgaga gagctaccct gtcctgctcc gcctcctcca gcatctccta catgtactgg      180

tatcagcaga agcccggcca ggcccctcgg ctgctgatct acgatacctc caagctggcc      240

tccggcatcc ccgacagatt ctccggctct ggctctggca ccgacttcac cctgaccatc      300

tcccggctgg aacccgagga cttcgccgtg tactactgcc accagcggga ctcctacccc      360

tggacctttg gccagggcac caagctggaa atcaagcgga ccgtggccgc tccctccgtg      420

ttcatcttcc caccttccga cgagcagctg aagtccggca ccgcttctgt cgtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

tccggcaact cccaggaatc cgtgaccgag caggactcca aggacagcac ctactccctg      600

tcctctaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      660

gtgacccacc agggcctgtc tagccccgtg accaagtctt tcaaccgggg cgagtgctga      720

tgaggatcct gatga                                                       735


<210>  78
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized NEO 103 light chain

<400>  78

Lys Leu Ala Thr Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Ile Val Leu Thr Gln 
            20                  25                  30          


Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
        35                  40                  45              


Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met Tyr Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala 
65                  70                  75                  80  


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            100                 105                 110         


Cys His Gln Arg Asp Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  79
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized NEO 103 heavy chain

<400>  79
aagcttgcca ccatggacct gctgtgcaag aacatgaagc acctgtggtt ctttctgctg       60

ctggtggccg ctcccagatg ggtgctgtct caggtgcagc tggtggaatc tggccctggc      120

ctggtgcagc cttccagatc cctgtctctg acctgctcct ccagcggctt cagcctgtcc      180

aagttcggcg tgaactgggt gcgacagcct cctggcaagg gcctggaatg ggtgggagtg      240

atctggggcg acggctccac ctcctacaac tccggcctga tctccagagt gaccatctcc      300

cgggacacct ccaagaacca gctgttcctg aagatggact ccctgaccgc cgaggacacc      360

gccgtgtact actgtgctag acctggcggc gactactggg gccagggcac aacagtgacc      420

gtgtcctccg cttccaccaa gggcccctct gtgtttcctc tggccccctc cagcaagtcc      480

acctctggtg gaactgccgc tctgggctgc ctcgtgaagg actacttccc cgagcccgtg      540

acagtgtcct ggaactctgg cgctctgacc tccggcgtgc acacctttcc agctgtgctg      600

cagtccagcg gcctgtactc cctgtcctcc gtcgtgaccg tgccttccag ctctctgggc      660

acccagacct acatctgcaa cgtgaaccac aagccctcca ataccaaggt ggacaagaag      720

gtggaaccca agtcctgcga caagacccac acctgtcccc cttgtcctgc ccctgaactg      780

ctgggcggac cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatctcc      840

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      900

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      960

cagtacaact ccacctaccg ggtggtgtcc gtgctgaccg tgctgcatca ggactggctg     1020

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgaaaag     1080

accatcagca aggctaaggg ccagccccgc gagccccagg tgtacacact gcctccatcc     1140

cgggaagaga tgaccaagaa tcaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1200

tccgatatcg ccgtggaatg ggagtccaac ggccagcccg agaacaacta caagaccacc     1260

ccccctgtgc tggactccga cggctcattc ttcctgtaca gcaagctgac agtggacaag     1320

tcccggtggc agcagggcaa cgtgttctcc tgctccgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagtccct gtccctgagc cccggcaagt gatgatgagg atcctga        1437


<210>  80
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized NEO 103 heavy chain

<400>  80

Lys Leu Ala Thr Met Asp Leu Leu Cys Lys Asn Met Lys His Leu Trp 
1               5                   10                  15      


Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp Val Leu Ser Gln Val 
            20                  25                  30          


Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Arg Ser Leu 
        35                  40                  45              


Ser Leu Thr Cys Ser Ser Ser Gly Phe Ser Leu Ser Lys Phe Gly Val 
    50                  55                  60                  


Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val Gly Val 
65                  70                  75                  80  


Ile Trp Gly Asp Gly Ser Thr Ser Tyr Asn Ser Gly Leu Ile Ser Arg 
                85                  90                  95      


Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Leu Phe Leu Lys Met 
            100                 105                 110         


Asp Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro 
        115                 120                 125             


Gly Gly Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  81
<211>  554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B6 antibody light chain

<400>  81
aacctgtggg gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga       60

aaaggtcact ttgaactgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa      120

ctacttggct tggtaccagc aaaaaccagg gcagtctcct aaattactga tctactgggc      180

atccactagg gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt      240

cactctcacc atcaacagtg tgcaggctga agacctggca gtttattact gcaagcaatc      300

ttataatctc ttcacgttcg gctcggggac aaagtmgaag taaaacgggc tgatgctgca      360

ccaactgtat ccatcttccc accatccagt gagcagttaa catctggagg tgcctcagtc      420

gtgtgcttct tgaacaactt ctaccccaaa gacaccaatg tcaagtggaa gattgatggc      480

agtgaacgac aaaatggcgt cctgaacagt tggactgatc aggacagcaa agacagcacc      540

tacagcatga gcag                                                        554


<210>  82
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B6 antibody light chain


<220>
<221>  MISC_FEATURE
<222>  (30)..(41)
<223>  4B6 antibody light chain CDR1

<220>
<221>  MISC_FEATURE
<222>  (59)..(61)
<223>  4B6 antibody light chain CDR2

<220>
<221>  MISC_FEATURE
<222>  (98)..(105)
<223>  4B6 antibody light chain CDR3

<400>  82

Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val 
1               5                   10                  15      


Ser Ala Gly Glu Lys Val Thr Leu Asn Cys Lys Ser Ser Gln Ser Leu 
            20                  25                  30          


Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        35                  40                  45              


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
    50                  55                  60                  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
65                  70                  75                  80  


Thr Leu Thr Ile Asn Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
                85                  90                  95      


Cys Lys Gln Ser Tyr Asn Leu Phe Thr Phe Gly Ser Gly Thr Lys Leu 
            100                 105                 110         


Glu Val Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
        115                 120                 125             


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
    130                 135                 140                 


Asn Asn Phe Tyr Pro Lys Asp Thr Asn Val Lys Trp Lys Ile Asp Gly 
145                 150                 155                 160 


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
                165                 170                 175     


Lys Asp Ser Thr Tyr Ser Met Ser 
            180                 


<210>  83
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B6 antibody light chain CDR1

<400>  83

Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B6 light chain CDR3

<400>  84

Lys Gln Ser Tyr Asn Leu Phe Thr 
1               5               


<210>  85
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B6 heavy chain

<400>  85
tgaggtgcag ctggaggagt ctggagctga actggcgagg cccggggctt cagtgaagct       60

gtcttgtaag gcttctggct actccttcac tgactattat ataaattggg tgaagcagag      120

gactggacag ggccttgagt ggattggaga aatttatcct ttaggtggta ctagtttcta      180

caatgagagg ttcaaggaca aggccacact gactgcagac aaatcctcca gcacagtcta      240

catggaactc agcagcctga catctgagga ctcggcagtc tatttctgtg caagagggga      300

taattattac gacgtctact ttgactactg gggccaaggg accacggtca c               351


<210>  86
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B6 antibody heavy chain


<220>
<221>  MISC_FEATURE
<222>  (26)..(33)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (51)..(58)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (97)..(109)
<223>  CDR3

<400>  86

Glu Val Gln Leu Glu Glu Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Leu Gly Gly Thr Ser Phe Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Asn Tyr Tyr Asp Val Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110     


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B6 heavy chain CDR1

<400>  87

Gly Tyr Ser Phe Thr Asp Tyr Tyr 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B6 heavy chain CDR2

<400>  88

Ile Tyr Pro Leu Gly Gly Thr Ser 
1               5               


<210>  89
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B6 heavy chain CDR3

<400>  89

Ala Arg Gly Asp Asn Tyr Tyr Asp Val Tyr Phe Asp Tyr 
1               5                   10              



