                         SEQUENCE LISTING

<110>  Emory University
       GEWIRTZ, Andrew T.
       ZHANG, Benyue
 
<120>  TLR5 LIGANDS, THERAPEUTIC METHODS, AND COMPOSITIONS RELATED 
       THERETO

<130>  10150 PCT

<150>  US 61/368,138
<151>  2010-09-24

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  495
<212>  PRT
<213>  Salmonella typhimurium

<400>  1

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala 
                85                  90                  95      


Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile 
            100                 105                 110         


Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly 
        115                 120                 125             


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu 
    130                 135                 140                 


Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu 
145                 150                 155                 160 


Lys Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Thr Leu Asn Val Gln 
                165                 170                 175     


Gln Lys Tyr Lys Val Ser Asp Thr Ala Ala Thr Val Thr Gly Tyr Ala 
            180                 185                 190         


Asp Thr Thr Ile Ala Leu Asp Asn Ser Thr Phe Lys Ala Ser Ala Thr 
        195                 200                 205             


Gly Leu Gly Gly Thr Asp Gln Lys Ile Asp Gly Asp Leu Lys Phe Asp 
    210                 215                 220                 


Asp Thr Thr Gly Lys Tyr Tyr Ala Lys Val Thr Val Thr Gly Gly Thr 
225                 230                 235                 240 


Gly Lys Asp Gly Tyr Tyr Glu Val Ser Val Asp Lys Thr Asn Gly Glu 
                245                 250                 255     


Val Thr Leu Ala Gly Gly Ala Thr Ser Pro Leu Thr Gly Gly Leu Pro 
            260                 265                 270         


Ala Thr Ala Thr Glu Asp Val Lys Asn Val Gln Val Ala Asn Ala Asp 
        275                 280                 285             


Leu Thr Glu Ala Lys Ala Ala Leu Thr Ala Ala Gly Val Thr Gly Thr 
    290                 295                 300                 


Ala Ser Val Val Lys Met Ser Tyr Thr Asp Asn Asn Gly Lys Thr Ile 
305                 310                 315                 320 


Asp Gly Gly Leu Ala Val Lys Val Gly Asp Asp Tyr Tyr Ser Ala Thr 
                325                 330                 335     


Gln Asn Lys Asp Gly Ser Ile Ser Ile Asn Thr Thr Lys Tyr Thr Ala 
            340                 345                 350         


Asp Asp Gly Thr Ser Lys Thr Ala Leu Asn Lys Leu Gly Gly Ala Asp 
        355                 360                 365             


Gly Lys Thr Glu Val Val Ser Ile Gly Gly Lys Thr Tyr Ala Ala Ser 
    370                 375                 380                 


Lys Ala Glu Gly His Asn Phe Lys Ala Gln Pro Asp Leu Ala Glu Ala 
385                 390                 395                 400 


Ala Ala Thr Thr Thr Glu Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu 
                405                 410                 415     


Ala Gln Val Asp Thr Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg 
            420                 425                 430         


Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Thr 
        435                 440                 445             


Ser Ala Arg Ser Arg Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser 
    450                 455                 460                 


Asn Met Ser Arg Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
465                 470                 475                 480 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
                485                 490                 495 


<210>  2
<211>  506
<212>  PRT
<213>  Salmonella typhimurium

<400>  2

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala 
                85                  90                  95      


Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile 
            100                 105                 110         


Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly 
        115                 120                 125             


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu 
    130                 135                 140                 


Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu 
145                 150                 155                 160 


Lys Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Ser Leu Asn Val Gln 
                165                 170                 175     


Lys Ala Tyr Asp Val Lys Asp Thr Ala Val Thr Thr Lys Ala Tyr Ala 
            180                 185                 190         


Asn Asn Gly Thr Thr Leu Asp Val Ser Gly Leu Asp Asp Ala Ala Ile 
        195                 200                 205             


Lys Ala Ala Thr Gly Gly Thr Asn Gly Thr Ala Ser Val Thr Gly Gly 
    210                 215                 220                 


Ala Val Lys Phe Asp Ala Asp Asn Asn Lys Tyr Phe Val Thr Ile Gly 
225                 230                 235                 240 


Gly Phe Thr Gly Ala Asp Ala Ala Lys Asn Gly Asp Tyr Glu Val Asn 
                245                 250                 255     


Val Ala Thr Asp Gly Thr Val Thr Leu Ala Ala Gly Ala Thr Lys Thr 
            260                 265                 270         


Thr Met Pro Ala Gly Ala Thr Thr Lys Thr Glu Val Gln Glu Leu Lys 
        275                 280                 285             


Asp Thr Pro Ala Val Val Ser Ala Asp Ala Lys Asn Ala Leu Ile Ala 
    290                 295                 300                 


Gly Gly Val Asp Ala Thr Asp Ala Asn Gly Ala Glu Leu Val Lys Met 
305                 310                 315                 320 


Ser Tyr Thr Asp Lys Asn Gly Lys Thr Ile Glu Gly Gly Tyr Ala Leu 
                325                 330                 335     


Lys Ala Gly Asp Lys Tyr Tyr Ala Ala Asp Tyr Asp Glu Ala Thr Gly 
            340                 345                 350         


Ala Ile Lys Ala Lys Thr Thr Ser Tyr Thr Ala Ala Asp Gly Thr Thr 
        355                 360                 365             


Lys Thr Ala Ala Asn Gln Leu Gly Gly Val Asp Gly Lys Thr Glu Val 
    370                 375                 380                 


Val Thr Ile Asp Gly Lys Thr Tyr Asn Ala Ser Lys Ala Ala Gly His 
385                 390                 395                 400 


Asp Phe Lys Ala Gln Pro Glu Leu Ala Glu Ala Ala Ala Lys Thr Thr 
                405                 410                 415     


Glu Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Ala 
            420                 425                 430         


Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
        435                 440                 445             


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg 
    450                 455                 460                 


Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala 
465                 470                 475                 480 


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
                485                 490                 495     


Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
            500                 505     


<210>  3
<211>  398
<212>  PRT
<213>  Salmonella typhimurium

<400>  3

Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Asn 
1               5                   10                  15      


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
            20                  25                  30          


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val Gln Ser Ala Asn 
        35                  40                  45              


Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile Gln Ala Glu Ile Thr 
    50                  55                  60                  


Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly Gln Thr Gln Phe Asn 
65                  70                  75                  80  


Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu Thr Ile Gln Val Gly 
                85                  90                  95      


Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Lys Gln Ile Asn Ser 
            100                 105                 110         


Gln Thr Leu Gly Leu Asp Thr Leu Asn Val Gln Gln Lys Tyr Lys Val 
        115                 120                 125             


Ser Asp Thr Ala Ala Thr Val Thr Gly Tyr Ala Asp Thr Thr Ile Ala 
    130                 135                 140                 


Leu Asp Asn Ser Thr Phe Lys Ala Ser Ala Thr Gly Leu Gly Gly Thr 
145                 150                 155                 160 


Asp Gln Lys Ile Asp Gly Asp Leu Lys Phe Asp Asp Thr Thr Gly Lys 
                165                 170                 175     


Tyr Tyr Ala Lys Val Thr Val Thr Gly Gly Thr Gly Lys Asp Gly Tyr 
            180                 185                 190         


Tyr Glu Val Ser Val Asp Lys Thr Asn Gly Glu Val Thr Leu Ala Gly 
        195                 200                 205             


Gly Ala Thr Ser Pro Leu Thr Gly Gly Leu Pro Ala Thr Ala Thr Glu 
    210                 215                 220                 


Asp Val Lys Asn Val Gln Val Ala Asn Ala Asp Leu Thr Glu Ala Lys 
225                 230                 235                 240 


Ala Ala Leu Thr Ala Ala Gly Val Thr Gly Thr Ala Ser Val Val Lys 
                245                 250                 255     


Met Ser Tyr Thr Asp Asn Asn Gly Lys Thr Ile Asp Gly Gly Leu Ala 
            260                 265                 270         


Val Lys Val Gly Asp Asp Tyr Tyr Ser Ala Thr Gln Asn Lys Asp Gly 
        275                 280                 285             


Ser Ile Ser Ile Asn Thr Thr Lys Tyr Thr Ala Asp Asp Gly Thr Ser 
    290                 295                 300                 


Lys Thr Ala Leu Asn Lys Leu Gly Gly Ala Asp Gly Lys Thr Glu Val 
305                 310                 315                 320 


Val Ser Ile Gly Gly Lys Thr Tyr Ala Ala Ser Lys Ala Glu Gly His 
                325                 330                 335     


Asn Phe Lys Ala Gln Pro Asp Leu Ala Glu Ala Ala Ala Thr Thr Thr 
            340                 345                 350         


Glu Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Thr 
        355                 360                 365             


Leu Arg Ser Asp Leu Ala Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
    370                 375                 380                 


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Thr Ser Ala Arg 
385                 390                 395             


<210>  4
<211>  290
<212>  PRT
<213>  Salmonella typhimurium

<400>  4

Met Ala Leu Thr Val Asn Thr Asn Ile Ala Ser Leu Asn Thr Gln Arg 
1               5                   10                  15      


Asn Leu Asn Asn Ser Ser Ala Ser Leu Asn Thr Ser Leu Gln Arg Leu 
            20                  25                  30          


Ser Thr Gly Ser Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Leu 
        35                  40                  45              


Gln Ile Ala Asn Arg Leu Thr Ser Gln Val Asn Gly Leu Asn Val Ala 
    50                  55                  60                  


Thr Lys Asn Ala Asn Asp Gly Ile Ser Leu Ala Gln Thr Ala Glu Gly 
65                  70                  75                  80  


Ala Leu Gln Gln Ser Thr Asn Ile Leu Gln Arg Met Arg Asp Leu Ser 
                85                  90                  95      


Leu Gln Ser Ala Asn Gly Ser Asn Ser Asp Ser Glu Arg Thr Ala Leu 
            100                 105                 110         


Asn Gly Glu Val Lys Gln Leu Gln Lys Glu Leu Asp Arg Ile Ser Asn 
        115                 120                 125             


Thr Thr Thr Phe Gly Gly Arg Lys Leu Leu Asp Gly Ser Phe Gly Val 
    130                 135                 140                 


Ala Ser Phe Gln Val Gly Ser Ala Ala Asn Glu Ile Ile Ser Val Gly 
145                 150                 155                 160 


Ile Gly Gly Gly Lys Leu Met Ile Lys Leu Lys Phe Gly Val Phe Phe 
                165                 170                 175     


Thr Val Leu Leu Ser Ser Ala Tyr Ala His Gly Thr Pro Gln Asn Ile 
            180                 185                 190         


Thr Asp Leu Cys Ala Glu Tyr His Asn Thr Gln Ile His Thr Leu Asn 
        195                 200                 205             


Asp Lys Ile Phe Ser Tyr Thr Glu Ser Leu Ala Gly Lys Arg Glu Met 
    210                 215                 220                 


Ala Ile Ile Thr Phe Lys Asn Gly Ala Thr Phe Gln Val Glu Val Pro 
225                 230                 235                 240 


Gly Ser Gln His Ile Asp Ser Gln Lys Lys Ala Ile Glu Arg Met Lys 
                245                 250                 255     


Asp Thr Leu Arg Ile Ala Tyr Leu Thr Glu Ala Lys Val Glu Lys Leu 
            260                 265                 270         


Cys Val Trp Asn Asn Lys Thr Pro His Ala Ile Ala Ala Ile Ser Met 
        275                 280                 285             


Ala Asn 
    290 


<210>  5
<211>  39
<212>  PRT
<213>  Salmonella typhimurium

<400>  5

Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu 
1               5                   10                  15      


Ala Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser 
            20                  25                  30          


Ile Gln Ala Glu Ile Thr Gln 
        35                  


<210>  6
<211>  44
<212>  PRT
<213>  Salmonella typhimurium

<400>  6

Thr Gln Phe Ser Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu Thr 
1               5                   10                  15      


Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Lys 
            20                  25                  30          


Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Thr Leu 
        35                  40                  


<210>  7
<211>  50
<212>  PRT
<213>  Salmonella typhimurium

<400>  7

Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu 
1               5                   10                  15      


Leu Ala Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp 
            20                  25                  30          


Ser Ile Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val 
        35                  40                  45              


Asn Gly 
    50  


<210>  8
<211>  98
<212>  PRT
<213>  Salmonella typhimurium

<400>  8

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala Ser 
    50                  55                  60                  


Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala 
65                  70                  75                  80  


Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val 
                85                  90                  95      


Gln Ser 
        


<210>  9
<211>  32
<212>  PRT
<213>  Salmonella typhimurium

<400>  9

Leu Gln Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Thr Leu Arg Ser 
1               5                   10                  15      


Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu 
            20                  25                  30          


<210>  10
<211>  29
<212>  PRT
<213>  Salmonella typhimurium

<400>  10

Thr Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala 
1               5                   10                  15      


Ile Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Ser 
            20                  25                  


<210>  11
<211>  51
<212>  PRT
<213>  Salmonella typhimurium

<400>  11

Glu Gln Ala Ala Lys Thr Thr Glu Asn Pro Leu Gln Lys Ile Asp Ala 
1               5                   10                  15      


Ala Leu Ala Gln Val Asp Thr Leu Arg Ser Asp Leu Gly Ala Val Gln 
            20                  25                  30          


Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Asn Asn 
        35                  40                  45              


Leu Ser Ser 
    50      


<210>  12
<211>  984
<212>  PRT
<213>  Salmonella typhimurium


<220>
<221>  MISC_FEATURE
<223>  GAG = GLU

<220>
<221>  MISC_FEATURE
<223>  CTT = LEU

<220>
<221>  MISC_FEATURE
<223>  CCG = PRO

<400>  12

Met Glu Thr Ala Arg Gly Gly Leu Tyr Ser Glu Arg His Ile Ser His 
1               5                   10                  15      


Ile Ser His Ile Ser His Ile Ser His Ile Ser His Ile Ser Gly Leu 
            20                  25                  30          


Tyr Met Glu Thr Ala Leu Ala Ser Glu Arg Met Glu Thr Thr His Arg 
        35                  40                  45              


Gly Leu Tyr Gly Leu Asn Gly Leu Asn Met Glu Thr Gly Leu Tyr Ala 
    50                  55                  60                  


Arg Gly Ala Ser Pro Cys Thr Thr Thr Tyr Arg Ala Ser Pro Ala Ser 
65                  70                  75                  80  


Pro Ala Ser Pro Ala Ser Pro Leu Tyr Ser Ala Ser Pro Cys Cys Gly 
                85                  90                  95      


Met Glu Thr Ala Leu Ala Gly Leu Asn Val Ala Leu Ile Leu Glu Ala 
            100                 105                 110         


Ser Asn Thr His Arg Ala Ser Asn Ser Glu Arg Cys Thr Thr Ser Glu 
        115                 120                 125             


Arg Cys Thr Thr Cys Thr Thr Thr His Arg Gly Leu Asn Ala Ser Asn 
    130                 135                 140                 


Ala Ser Asn Cys Thr Thr Ala Ser Asn Leu Tyr Ser Ser Glu Arg Gly 
145                 150                 155                 160 


Leu Asn Ser Glu Arg Ser Glu Arg Cys Thr Thr Ser Glu Arg Ser Glu 
                165                 170                 175     


Arg Ala Leu Ala Ile Leu Glu Gly Ala Gly Ala Arg Gly Cys Thr Thr 
            180                 185                 190         


Ser Glu Arg Ser Glu Arg Gly Leu Tyr Cys Thr Thr Ala Arg Gly Ile 
        195                 200                 205             


Leu Glu Ala Ser Asn Ser Glu Arg Ala Leu Ala Leu Tyr Ser Ala Ser 
    210                 215                 220                 


Pro Ala Ser Pro Ala Leu Ala Ala Leu Ala Gly Leu Tyr Gly Leu Asn 
225                 230                 235                 240 


Ala Leu Ala Ile Leu Glu Ala Leu Ala Ala Ser Asn Ala Arg Gly Pro 
                245                 250                 255     


His Glu Thr His Arg Ser Glu Arg Ala Ser Asn Ile Leu Glu Leu Tyr 
            260                 265                 270         


Ser Gly Leu Tyr Cys Thr Thr Thr His Arg Gly Leu Asn Ala Leu Ala 
        275                 280                 285             


Ser Glu Arg Ala Arg Gly Ala Ser Asn Ala Leu Ala Ala Ser Asn Ala 
    290                 295                 300                 


Ser Pro Gly Leu Tyr Ile Leu Glu Ser Glu Arg Ile Leu Glu Ala Leu 
305                 310                 315                 320 


Ala Gly Leu Asn Thr His Arg Thr His Arg Gly Ala Gly Gly Leu Tyr 
                325                 330                 335     


Ala Leu Ala Cys Thr Thr Ala Ser Asn Gly Ala Gly Ile Leu Glu Ala 
            340                 345                 350         


Ser Asn Ala Ser Asn Ala Ser Asn Cys Thr Thr Gly Leu Asn Ala Arg 
        355                 360                 365             


Gly Val Ala Leu Ala Arg Gly Gly Ala Gly Cys Thr Thr Ser Glu Arg 
    370                 375                 380                 


Val Ala Leu Gly Leu Asn Ala Leu Ala Thr His Arg Ala Ser Asn Gly 
385                 390                 395                 400 


Leu Tyr Thr His Arg Ala Ser Asn Ser Glu Arg Ala Ser Pro Ser Glu 
                405                 410                 415     


Arg Ala Ser Pro Cys Thr Thr Leu Tyr Ser Ser Glu Arg Ile Leu Glu 
            420                 425                 430         


Gly Leu Asn Ala Ser Pro Gly Ala Gly Ile Leu Glu Gly Leu Asn Gly 
        435                 440                 445             


Leu Asn Ala Arg Gly Cys Thr Thr Gly Ala Gly Gly Ala Gly Ile Leu 
    450                 455                 460                 


Glu Ala Ser Pro Ala Arg Gly Val Ala Leu Ser Glu Arg Ala Ser Asn 
465                 470                 475                 480 


Gly Leu Asn Thr His Arg Gly Leu Asn Pro His Glu Ala Ser Asn Gly 
                485                 490                 495     


Leu Tyr Val Ala Leu Leu Tyr Ser Val Ala Leu Cys Thr Thr Ser Glu 
            500                 505                 510         


Arg Gly Leu Asn Ala Ser Pro Ala Ser Asn Gly Leu Asn Met Glu Thr 
        515                 520                 525             


Leu Tyr Ser Ile Leu Glu Gly Leu Asn Val Ala Leu Gly Leu Tyr Ala 
    530                 535                 540                 


Leu Ala Ala Ser Asn Ala Ser Pro Gly Leu Tyr Gly Ala Gly Thr His 
545                 550                 555                 560 


Arg Ile Leu Glu Thr His Arg Ile Leu Glu Ala Ser Pro Cys Thr Thr 
                565                 570                 575     


Gly Leu Asn Leu Tyr Ser Ile Leu Glu Ala Ser Pro Val Ala Leu Leu 
            580                 585                 590         


Tyr Ser Ser Glu Arg Cys Thr Thr Gly Leu Tyr Cys Thr Thr Ala Ser 
        595                 600                 605             


Pro Gly Leu Tyr Pro His Glu Ala Ser Asn Val Ala Leu Ala Ser Asn 
    610                 615                 620                 


Ser Glu Arg Cys Cys Gly Gly Leu Tyr Ile Leu Glu Ser Glu Arg Gly 
625                 630                 635                 640 


Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Ile Leu 
                645                 650                 655     


Glu Cys Thr Thr Ala Ser Pro Ser Glu Arg Met Glu Thr Gly Leu Tyr 
            660                 665                 670         


Thr His Arg Cys Thr Thr Ile Leu Glu Ala Ser Asn Gly Ala Gly Ala 
        675                 680                 685             


Ser Pro Ala Leu Ala Ala Leu Ala Ala Leu Ala Ala Leu Ala Leu Tyr 
    690                 695                 700                 


Ser Leu Tyr Ser Ser Glu Arg Thr His Arg Ala Leu Ala Ala Ser Asn 
705                 710                 715                 720 


Cys Cys Gly Cys Thr Thr Ala Leu Ala Ser Glu Arg Ile Leu Glu Ala 
                725                 730                 735     


Ser Pro Ser Glu Arg Ala Leu Ala Cys Thr Thr Ser Glu Arg Leu Tyr 
            740                 745                 750         


Ser Val Ala Leu Ala Ser Pro Ala Leu Ala Val Ala Leu Ala Arg Gly 
        755                 760                 765             


Ser Glu Arg Ser Glu Arg Cys Thr Thr Gly Leu Tyr Ala Leu Ala Ile 
    770                 775                 780                 


Leu Glu Gly Leu Asn Ala Ser Asn Ala Arg Gly Pro His Glu Ala Ser 
785                 790                 795                 800 


Pro Ser Glu Arg Ala Leu Ala Ile Leu Glu Thr His Arg Ala Ser Asn 
                805                 810                 815     


Cys Thr Thr Gly Leu Tyr Ala Ser Asn Thr His Arg Val Ala Leu Thr 
            820                 825                 830         


His Arg Ala Ser Asn Cys Thr Thr Ala Ser Asn Ser Glu Arg Ala Leu 
        835                 840                 845             


Ala Ala Arg Gly Ser Glu Arg Ala Arg Gly Ile Leu Glu Gly Ala Gly 
    850                 855                 860                 


Ala Ser Pro Ala Leu Ala Ala Ser Pro Thr Tyr Arg Ala Leu Ala Thr 
865                 870                 875                 880 


His Arg Gly Ala Gly Val Ala Leu Ser Glu Arg Ala Ser Asn Met Glu 
                885                 890                 895     


Thr Ser Glu Arg Leu Tyr Ser Ala Leu Ala Gly Leu Asn Ile Leu Glu 
            900                 905                 910         


Cys Thr Thr Gly Leu Asn Gly Leu Asn Ala Leu Ala Gly Leu Tyr Thr 
        915                 920                 925             


His Arg Ser Glu Arg Val Ala Leu Cys Thr Thr Ala Leu Ala Gly Leu 
    930                 935                 940                 


Asn Ala Leu Ala Ala Ser Asn Gly Leu Asn Val Ala Leu Cys Cys Gly 
945                 950                 955                 960 


Gly Leu Asn Ala Ser Asn Val Ala Leu Cys Thr Thr Ser Glu Arg Cys 
                965                 970                 975     


Thr Thr Cys Thr Thr Ala Arg Gly 
            980                 


