                               SEQUENCE LISTING	

<110> ZHU, YORK YUANYUAN
      CHEN, LI
      LI, TIEJUN
      LU, YIXIANG
      SUN, YUNCHENG
      WANG, JINKANG
      TUO, JINGSHENG
 
<120> THE APPLICATION OF HIGHLY CONSERVED DOMAIN SEQUENCES FROM VIRAL 
      GENOME AS TEMPLATE TO DESIGN THERAPEUTIC SLIRNAS

<130> 40246-701.601

<140> 12/886,446
<141> 2010-09-20

<150> 12/886,446
<151> 2010-09-20

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 644
<212> DNA
<213> enterovirus

<400> 1
ttaaaacagc tctggggttg ttcccacccc agaggcccac gtggcggcta gtactccggt       60

accccggtac ccttgtacgc ctgttttata ctccctttcc caagtaactt tagaagaaat      120

aaactaatgt tcaacaggag ggggtacaaa ccagtaccac cacgaacaca cacttctgtt      180

tccccggtga agttgcatag actgtaccca cggttgaaag cgatgaatcc gttacccgct      240

taggtacttc gagaagccta gtatcatctt ggaatcttcg atgcgttgcg atcagcactc      300

taccccgagt gtagcttggg tcgatgagtc tggacacccc acaccggcga cggtggtcca      360

ggctgcgttg gcggcctacc catggctagc accatgggac gctagttgtg aacaaggtgc      420

gaagagccta ttgagctacc tgagagtcct ccggcccctg aatgcggcta atcccaacca      480

cggagcaaat gctcacaatc cagtgagtgg tttgtcgtaa tgcgcaagtc tgtggcggaa      540

ccgactactt tgggcgtccg tgtttccttt tatttttatt atggctgctt atggtgacaa      600

tctgagattg ttatcatata gctattggat tagccatccg gtga                       644


<210> 2
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
uagguacuuc gagaagccua gua                                               23


<210> 3
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
uacuaggcuu cucgaaguac cua                                               23


<210> 4
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 4
caaugcauug agaggccugg autt                                              24


<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	

<400> 5
auccaggccu cucaaugcau ugtt                                              24


<210> 6
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	

<400> 6
uagguacuuc gagaagccua guatt                                             25


<210> 7
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	

<400> 7
uacuaggcuu cucgaaguac cuatt                                             25


<210> 8
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	

<400> 8
ccugagaguc cuccggcccc utt                                               23


<210> 9
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	

<400> 9
aggggccgga ggacucucag gtt                                               23


<210> 10
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	

<400> 10
agagagaaag uagagaaggg ctt                                               23


<210> 11
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	

<400> 11
gcccuucucu acuuucucuc utt                                               23


<210> 12
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	

<400> 12
uaggaaccca agaaccccuc ctt                                               23


<210> 13
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	

<400> 13
ggagggguuc uuggguuccu att                                               23


<210> 14
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	


<220>
<221> modified_base
<222> (24)..(25)
<223> Cytosine, guanine, adenine, and thymine, or the deoxygen forms 
      thereof

<220>
<221> misc_feature
<222> (24)..(25)
<223> This region may encompass 0-2 repeating 'N' bases

<400> 14
uagguacuuc gagaagccua guann                                             25


<210> 15
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide	


<220>
<221> modified_base
<222> (24)..(25)
<223> Cytosine, guanine, adenine, and thymine, or the deoxygen forms 
      thereof

<220>
<221> misc_feature
<222> (24)..(25)
<223> This region may encompass 0-2 repeating 'N' bases

<400> 15
uacuaggcuu cucgaaguac cuann                                             25


<210> 16
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 16
taggtacttc gagaagccta gtatt                                             25


<210> 17
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 17
uacuaggcuu cucgaaguac cuatt                                             25


<210> 18
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 18
caatgcattg agaggcctgg attt                                              24


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
atccaggcct ctcaatgcat tgtt                                              24


<210> 20
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ctggaactac acaagaacga gag                                               23


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
cttcaagtcc tcatagatgc tacc                                              24


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
tttagagtcc aacggcttag                                                   20


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
tggaggttca gtgaccttag                                                   20


<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
gacatcttcc aggagtacc                                                    19


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
tgctgtagga agctcatctc                                                   20


<210> 26
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
gtatgactcc actcacggca aa                                                22


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
ggtctcgctc ctggaagatg                                                   20


<210> 28
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
tttttttttt ttttt                                                        15


