
                                SEQUENCE LISTING

<110> Sul, Hei Sook
      Ahmadian, Maryam

<120> Compositions and Methods for Modulating
  Desnutrin-Mediated Adipocyte Lipolysis
  

<130> BERK-148WO

<150> 61/384,617          
<151> 2010-09-20  

<160> 31

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 504
<212> PRT
<213> Homo sapiens

<400> 1
Met Phe Pro Arg Glu Lys Thr Trp Asn Ile Ser Phe Ala Gly Cys Gly
 1               5                  10                  15      
Phe Leu Gly Val Tyr Tyr Val Gly Val Ala Ser Cys Leu Arg Glu His
            20                  25                  30          
Ala Pro Phe Leu Val Ala Asn Ala Thr His Ile Tyr Gly Ala Ser Ala
        35                  40                  45              
Gly Ala Leu Thr Ala Thr Ala Leu Val Thr Gly Val Cys Leu Gly Glu
    50                  55                  60                  
Ala Gly Ala Lys Phe Ile Glu Val Ser Lys Glu Ala Arg Lys Arg Phe
65                  70                  75                  80  
Leu Gly Pro Leu His Pro Ser Phe Asn Leu Val Lys Ile Ile Arg Ser
                85                  90                  95      
Phe Leu Leu Lys Val Leu Pro Ala Asp Ser His Glu His Ala Ser Gly
            100                 105                 110         
Arg Leu Gly Ile Ser Leu Thr Arg Val Ser Asp Gly Glu Asn Val Ile
        115                 120                 125             
Ile Ser His Phe Asn Ser Lys Asp Glu Leu Ile Gln Ala Asn Val Cys
    130                 135                 140                 
Ser Gly Phe Ile Pro Val Tyr Cys Gly Leu Ile Pro Pro Ser Leu Gln
145                 150                 155                 160 
Gly Val Arg Tyr Val Asp Gly Gly Ile Ser Asp Asn Leu Pro Leu Tyr
                165                 170                 175     
Glu Leu Lys Asn Thr Ile Thr Val Ser Pro Phe Ser Gly Glu Ser Asp
            180                 185                 190         
Ile Cys Pro Gln Asp Ser Ser Thr Asn Ile His Glu Leu Arg Val Thr
        195                 200                 205             
Asn Thr Ser Ile Gln Phe Asn Leu Arg Asn Leu Tyr Arg Leu Ser Lys
    210                 215                 220                 
Ala Leu Phe Pro Pro Glu Pro Leu Val Leu Arg Glu Met Cys Lys Gln
225                 230                 235                 240 
Gly Tyr Arg Asp Gly Leu Arg Phe Leu Gln Arg Asn Gly Leu Leu Asn
                245                 250                 255     
Arg Pro Asn Pro Leu Leu Ala Leu Pro Pro Ala Arg Pro His Gly Pro
            260                 265                 270         
Glu Asp Lys Asp Gln Ala Val Glu Ser Ala Gln Ala Glu Asp Tyr Ser
        275                 280                 285             
Gln Leu Pro Gly Glu Asp His Ile Leu Glu His Leu Pro Ala Arg Leu
    290                 295                 300                 
Asn Glu Ala Leu Leu Glu Ala Cys Val Glu Pro Thr Asp Leu Leu Thr
305                 310                 315                 320 
Thr Leu Ser Asn Met Leu Pro Val Arg Leu Ala Thr Ala Met Met Val
                325                 330                 335     
Pro Tyr Thr Leu Pro Leu Glu Ser Ala Leu Ser Phe Thr Ile Arg Leu
            340                 345                 350         
Leu Glu Trp Leu Pro Asp Val Pro Glu Asp Ile Arg Trp Met Lys Glu
        355                 360                 365             
Gln Thr Gly Ser Ile Cys Gln Tyr Leu Val Met Arg Ala Lys Arg Lys
    370                 375                 380                 
Leu Gly Arg His Leu Pro Ser Arg Leu Pro Glu Gln Val Glu Leu Arg
385                 390                 395                 400 
Arg Val Gln Ser Leu Pro Ser Val Pro Leu Ser Cys Ala Ala Tyr Arg
                405                 410                 415     
Glu Ala Leu Pro Gly Trp Met Arg Asn Asn Leu Ser Leu Gly Asp Ala
            420                 425                 430         
Leu Ala Lys Trp Glu Glu Cys Gln Arg Gln Leu Leu Leu Gly Leu Phe
        435                 440                 445             
Cys Thr Asn Val Ala Phe Pro Pro Glu Ala Leu Arg Met Arg Ala Pro
    450                 455                 460                 
Ala Asp Pro Ala Pro Ala Pro Ala Asp Pro Ala Ser Pro Gln His Gln
465                 470                 475                 480 
Leu Ala Gly Pro Ala Pro Leu Leu Ser Thr Pro Ala Pro Glu Ala Arg
                485                 490                 495     
Pro Val Ile Gly Ala Leu Gly Leu
            500                 


<210> 2
<211> 1515
<212> DNA
<213> Homo sapiens

<400> 2
atgtttcccc gcgagaagac gtggaacatc tcgttcgcgg gctgcggctt cctcggcgtc 60
tactacgtcg gcgtggcctc ctgcctccgc gagcacgcgc ccttcctggt ggccaacgcc 120
acgcacatct acggcgcctc ggccggggcg ctcacggcca cggcgctggt caccggggtc 180
tgcctgggtg aggctggtgc caagttcatt gaggtatcta aagaggcccg gaagcggttc 240
ctgggccccc tgcacccctc cttcaacctg gtaaagatca tccgcagttt cctgctgaag 300
gtcctgcctg ctgatagcca tgagcatgcc agtgggcgcc tgggcatctc cctgacccgc 360
gtgtcagacg gcgagaatgt cattatatcc cacttcaact ccaaggacga gctcatccag 420
gccaatgtct gcagcggttt catccccgtg tactgtgggc tcatccctcc ctccctccag 480
ggggtgcgct acgtggatgg tggcatttca gacaacctgc cactctatga gcttaagaac 540
accatcacag tgtccccctt ctcgggcgag agtgacatct gtccgcagga cagctccacc 600
aacatccacg agctgcgggt caccaacacc agcatccagt tcaacctgcg caacctctac 660
cgcctctcca aggccctctt cccgccggag cccctggtgc tgcgagagat gtgcaagcag 720
ggataccggg atggcctgcg ctttctgcag cggaacggcc tcctgaaccg gcccaacccc 780
ttgctggcgt tgccccccgc ccgcccccac ggcccagagg acaaggacca ggcagtggag 840
agcgcccaag cggaggatta ctcgcagctg cccggagaag atcacatcct ggagcacctg 900
cccgcccggc tcaatgaggc cctgctggag gcctgcgtgg agcccacgga cctgctgacc 960
accctctcca acatgctgcc tgtgcgtctg gccacggcca tgatggtgcc ctacacgctg 1020
ccgctggaga gcgctctgtc cttcaccatc cgcttgctgg agtggctgcc cgacgttccc 1080
gaggacatcc ggtggatgaa ggagcagacg ggcagcatct gccagtacct ggtgatgcgc 1140
gccaagagga agctgggcag gcacctgccc tccaggctgc cggagcaggt ggagctgcgc 1200
cgcgtccagt cgctgccgtc cgtgccgctg tcctgcgccg cctacagaga ggcactgccc 1260
ggctggatgc gcaacaacct ctcgctgggg gacgcgctgg ccaagtggga ggagtgccag 1320
cgccagctgc tgctcggcct cttctgcacc aacgtggcct tcccgcccga agctctgcgc 1380
atgcgcgcac ccgccgaccc ggctcccgcc cccgcggacc cagcatcccc gcagcaccag 1440
ctggccgggc ctgccccctt gctgagcacc cctgctcccg aggcccggcc cgtgatcggg 1500
gccctggggc tgtga                                                  1515

<210> 3
<211> 306
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Gly Leu Thr Ala Ser Asp Val His Pro Thr Leu Gly Val Gln
 1               5                  10                  15      
Leu Phe Ser Ala Gly Ile Ala Ala Cys Leu Ala Asp Val Ile Thr Phe
            20                  25                  30          
Pro Leu Asp Thr Ala Lys Val Arg Leu Gln Val Gln Gly Glu Cys Pro
        35                  40                  45              
Thr Ser Ser Val Ile Arg Tyr Lys Gly Val Leu Gly Thr Ile Thr Ala
    50                  55                  60                  
Val Val Lys Thr Glu Gly Arg Met Lys Leu Tyr Ser Gly Leu Pro Ala
65                  70                  75                  80  
Gly Leu Gln Arg Gln Ile Ser Ser Ala Ser Leu Arg Ile Gly Leu Tyr
                85                  90                  95      
Asp Thr Val Gln Glu Phe Leu Thr Ala Gly Lys Glu Thr Pro Ser Leu
            100                 105                 110         
Gly Ser Lys Ile Leu Ala Gly Leu Thr Thr Gly Gly Val Ala Val Phe
        115                 120                 125             
Ile Gly Gln Pro Thr Glu Val Val Lys Val Arg Leu Gln Ala Gln Ser
    130                 135                 140                 
His Leu His Gly Ile Lys Pro Arg Tyr Thr Gly Thr Tyr Asn Ala Tyr
145                 150                 155                 160 
Arg Ile Ile Ala Thr Thr Glu Gly Leu Thr Gly Leu Trp Lys Gly Thr
                165                 170                 175     
Thr Pro Asn Leu Met Arg Ser Val Ile Ile Asn Cys Thr Glu Leu Val
            180                 185                 190         
Thr Tyr Asp Leu Met Lys Glu Ala Phe Val Lys Asn Asn Ile Leu Ala
        195                 200                 205             
Asp Asp Val Pro Cys His Leu Val Ser Ala Leu Ile Ala Gly Phe Cys
    210                 215                 220                 
Ala Thr Ala Met Ser Ser Pro Val Asp Val Val Lys Thr Arg Phe Ile
225                 230                 235                 240 
Asn Ser Pro Pro Gly Gln Tyr Lys Ser Val Pro Asn Cys Ala Met Lys
                245                 250                 255     
Val Phe Thr Asn Glu Gly Pro Thr Ala Phe Phe Lys Gly Leu Val Pro
            260                 265                 270         
Ser Phe Leu Arg Leu Gly Ser Trp Asn Val Ile Met Phe Val Cys Phe
        275                 280                 285             
Glu Gln Leu Lys Arg Glu Leu Ser Lys Ser Arg Gln Thr Met Asp Cys
    290                 295                 300                 
Ala Thr
305     


<210> 4
<211> 921
<212> DNA
<213> Homo sapiens

<400> 4
atggggggcc tgacagcctc ggacgtacac ccgaccctgg gggtccagct cttctcagct 60
ggaatagcgg cgtgcttggc ggacgtgatc accttcccgc tggacacggc caaagtccgg 120
ctccaggtcc aaggtgaatg cccgacgtcc agtgttatta ggtataaagg tgtcctggga 180
acaatcaccg ctgtggtaaa aacagaaggg cggatgaaac tctacagcgg gctgcctgcg 240
gggcttcagc ggcaaatcag ctccgcctct ctcaggatcg gcctctacga cacggtccag 300
gagttcctca ccgcagggaa agaaacacct agtttaggaa gcaagatttt agctggtcta 360
acgactggag gagtggcagt attcattggg caacccacag aggtcgtgaa agtcagactt 420
caagcacaga gccatctcca cggaatcaaa cctcgctaca cggggactta taatgcgtac 480
agaataatag caacaaccga aggcttgacg ggtctttgga aagggactac tcccaatctg 540
atgagaagtg tcatcatcaa ttgtacagag ctagtaacat atgatctaat gaaggaggcc 600
tttgtgaaaa acaacatatt agcagatgac gtcccctgcc acttggtgtc ggctcttatc 660
gctggatttt gcgcaacagc tatgtcctcc ccggtggatg tagtaaaaac cagatttatt 720
aattctccac caggacagta caaaagtgtg cccaactgtg caatgaaagt gttcactaac 780
gaaggaccaa cggctttctt caaggggttg gtaccttcct tcttgcgact tggatcctgg 840
aacgtcatta tgtttgtgtg ctttgaacaa ctgaaacgag aactgtcaaa gtcaaggcag 900
actatggact gtgccacata a                                           921

<210> 5
<211> 167
<212> PRT
<213> Homo sapiens

<400> 5
Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu
 1               5                  10                  15      
Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys
            20                  25                  30          
Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr
        35                  40                  45              
Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro
    50                  55                  60                  
Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala
65                  70                  75                  80  
Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln
                85                  90                  95      
Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala
            100                 105                 110         
Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu
        115                 120                 125             
Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val
    130                 135                 140                 
Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln
145                 150                 155                 160 
Leu Asp Leu Ser Pro Gly Cys
                165         


<210> 6
<211> 504
<212> DNA
<213> Homo sapiens

<400> 6
atgcattggg gaaccctgtg cggattcttg tggctttggc cctatctttt ctatgtccaa 60
gctgtgccca tccaaaaagt ccaagatgac accaaaaccc tcatcaagac aattgtcacc 120
aggatcaatg acatttcaca cacgcagtca gtctcctcca aacagaaagt caccggtttg 180
gacttcattc ctgggctcca ccccatcctg accttatcca agatggacca gacactggca 240
gtctaccaac agatcctcac cagtatgcct tccagaaacg tgatccaaat atccaacgac 300
ctggagaacc tccgggatct tcttcacgtg ctggccttct ctaagagctg ccacttgccc 360
tgggccagtg gcctggagac cttggacagc ctggggggtg tcctggaagc ttcaggctac 420
tccacagagg tggtggccct gagcaggctg caggggtctc tgcaggacat gctgtggcag 480
ctggacctca gccctgggtg ctga                                        504

<210> 7
<211> 244
<212> PRT
<213> Homo sapiens

<400> 7
Met Leu Leu Leu Gly Ala Val Leu Leu Leu Leu Ala Leu Pro Gly His
 1               5                  10                  15      
Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro Leu Pro
            20                  25                  30          
Lys Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro Gly
        35                  40                  45              
His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly Glu
    50                  55                  60                  
Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp Ile
65                  70                  75                  80  
Gly Glu Thr Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro Gly
                85                  90                  95      
Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala Tyr Val Tyr Arg
            100                 105                 110         
Ser Ala Phe Ser Val Gly Leu Glu Thr Tyr Val Thr Ile Pro Asn Met
        115                 120                 125             
Pro Ile Arg Phe Thr Lys Ile Phe Tyr Asn Gln Gln Asn His Tyr Asp
    130                 135                 140                 
Gly Ser Thr Gly Lys Phe His Cys Asn Ile Pro Gly Leu Tyr Tyr Phe
145                 150                 155                 160 
Ala Tyr His Ile Thr Val Tyr Met Lys Asp Val Lys Val Ser Leu Phe
                165                 170                 175     
Lys Lys Asp Lys Ala Met Leu Phe Thr Tyr Asp Gln Tyr Gln Glu Asn
            180                 185                 190         
Asn Val Asp Gln Ala Ser Gly Ser Val Leu Leu His Leu Glu Val Gly
        195                 200                 205             
Asp Gln Val Trp Leu Gln Val Tyr Gly Glu Gly Glu Arg Asn Gly Leu
    210                 215                 220                 
Tyr Ala Asp Asn Asp Asn Asp Ser Thr Phe Thr Gly Phe Leu Leu Tyr
225                 230                 235                 240 
His Asp Thr Asn
                


<210> 8
<211> 735
<212> DNA
<213> Homo sapiens

<400> 8
atgctgttgc tgggagctgt tctactgcta ttagctctgc ccggtcatga ccaggaaacc 60
acgactcaag ggcccggagt cctgcttccc ctgcccaagg gggcctgcac aggttggatg 120
gcgggcatcc cagggcatcc gggccataat ggggccccag gccgtgatgg cagagatggc 180
acccctggtg agaagggtga gaaaggagat ccaggtctta ttggtcctaa gggagacatc 240
ggtgaaaccg gagtacccgg ggctgaaggt ccccgaggct ttccgggaat ccaaggcagg 300
aaaggagaac ctggagaagg tgcctatgta taccgctcag cattcagtgt gggattggag 360
acttacgtta ctatccccaa catgcccatt cgctttacca agatcttcta caatcagcaa 420
aaccactatg atggctccac tggtaaattc cactgcaaca ttcctgggct gtactacttt 480
gcctaccaca tcacagtcta tatgaaggat gtgaaggtca gcctcttcaa gaaggacaag 540
gctatgctct tcacctatga tcagtaccag gaaaataatg tggaccaggc ctccggctct 600
gtgctcctgc atctggaggt gggcgaccaa gtctggctcc aggtgtatgg ggaaggagag 660
cgtaatggac tctatgctga taatgacaat gactccacct tcacaggctt tcttctctac 720
catgacacca actga                                                  735

<210> 9
<211> 108
<212> PRT
<213> Homo sapiens

<400> 9
Met Lys Ala Leu Cys Leu Leu Leu Leu Pro Val Leu Gly Leu Leu Val
 1               5                  10                  15      
Ser Ser Lys Thr Leu Cys Ser Met Glu Glu Ala Ile Asn Glu Arg Ile
            20                  25                  30          
Gln Glu Val Ala Gly Ser Leu Ile Phe Arg Ala Ile Ser Ser Ile Gly
        35                  40                  45              
Leu Glu Cys Gln Ser Val Thr Ser Arg Gly Asp Leu Ala Thr Cys Pro
    50                  55                  60                  
Arg Gly Phe Ala Val Thr Gly Cys Thr Cys Gly Ser Ala Cys Gly Ser
65                  70                  75                  80  
Trp Asp Val Arg Ala Glu Thr Thr Cys His Cys Gln Cys Ala Gly Met
                85                  90                  95      
Asp Trp Thr Gly Ala Arg Cys Cys Arg Val Gln Pro
            100                 105             


<210> 10
<211> 327
<212> DNA
<213> Homo sapiens

<400> 10
atgaaagctc tctgtctcct cctcctccct gtcctggggc tgttggtgtc tagcaagacc 60
ctgtgctcca tggaagaagc catcaatgag aggatccagg aggtcgccgg ctccctaata 120
tttagggcaa taagcagcat tggcctggag tgccagagcg tcacctccag gggggacctg 180
gctacttgcc cccgaggctt cgccgtcacc ggctgcactt gtggctccgc ctgtggctcg 240
tgggatgtgc gcgccgagac cacatgtcac tgccagtgcg cgggcatgga ctggaccgga 300
gcgcgctgct gtcgtgtgca gccctga                                     327

<210> 11
<211> 658
<212> PRT
<213> Homo sapiens

<400> 11
Met Val Pro Arg Leu Leu Leu Arg Ala Trp Pro Arg Gly Pro Ala Val
 1               5                  10                  15      
Gly Pro Gly Ala Pro Ser Arg Pro Leu Ser Ala Gly Ser Gly Pro Gly
            20                  25                  30          
Gln Tyr Leu Gln Arg Ser Ile Val Pro Thr Met His Tyr Gln Asp Ser
        35                  40                  45              
Leu Pro Arg Leu Pro Ile Pro Lys Leu Glu Asp Thr Ile Arg Arg Tyr
    50                  55                  60                  
Leu Ser Ala Gln Lys Pro Leu Leu Asn Asp Gly Gln Phe Arg Lys Thr
65                  70                  75                  80  
Glu Gln Phe Cys Lys Ser Phe Glu Asn Gly Ile Gly Lys Glu Leu His
                85                  90                  95      
Glu Gln Leu Val Ala Leu Asp Lys Gln Asn Lys His Thr Ser Tyr Ile
            100                 105                 110         
Ser Gly Pro Trp Phe Asp Met Tyr Leu Ser Ala Arg Asp Ser Val Val
        115                 120                 125             
Leu Asn Phe Asn Pro Phe Met Ala Phe Asn Pro Asp Pro Lys Ser Glu
    130                 135                 140                 
Tyr Asn Asp Gln Leu Thr Arg Ala Thr Asn Met Thr Val Ser Ala Ile
145                 150                 155                 160 
Arg Phe Leu Lys Thr Leu Arg Ala Gly Leu Leu Glu Pro Glu Val Phe
                165                 170                 175     
His Leu Asn Pro Ala Lys Ser Asp Thr Ile Thr Phe Lys Arg Leu Ile
            180                 185                 190         
Arg Phe Val Pro Ser Ser Leu Ser Trp Tyr Gly Ala Tyr Leu Val Asn
        195                 200                 205             
Ala Tyr Pro Leu Asp Met Ser Gln Tyr Phe Arg Leu Phe Asn Ser Thr
    210                 215                 220                 
Arg Leu Pro Lys Pro Ser Arg Asp Glu Leu Phe Thr Asp Asp Lys Ala
225                 230                 235                 240 
Arg His Leu Leu Val Leu Arg Lys Gly Asn Phe Tyr Ile Phe Asp Val
                245                 250                 255     
Leu Asp Gln Asp Gly Asn Ile Val Ser Pro Ser Glu Ile Gln Ala His
            260                 265                 270         
Leu Lys Tyr Ile Leu Ser Asp Ser Ser Pro Ala Pro Glu Phe Pro Leu
        275                 280                 285             
Ala Tyr Leu Thr Ser Glu Asn Arg Asp Ile Trp Ala Glu Leu Arg Gln
    290                 295                 300                 
Lys Leu Met Ser Ser Gly Asn Glu Glu Ser Leu Arg Lys Val Asp Ser
305                 310                 315                 320 
Ala Val Phe Cys Leu Cys Leu Asp Asp Phe Pro Ile Lys Asp Leu Val
                325                 330                 335     
His Leu Ser His Asn Met Leu His Gly Asp Gly Thr Asn Arg Trp Phe
            340                 345                 350         
Asp Lys Ser Phe Asn Leu Ile Ile Ala Lys Asp Gly Ser Thr Ala Val
        355                 360                 365             
His Phe Glu His Ser Trp Gly Asp Gly Val Ala Val Leu Arg Phe Phe
    370                 375                 380                 
Asn Glu Val Phe Lys Asp Ser Thr Gln Thr Pro Ala Val Thr Pro Gln
385                 390                 395                 400 
Ser Gln Pro Ala Thr Thr Asp Ser Thr Val Thr Val Gln Lys Leu Asn
                405                 410                 415     
Phe Glu Leu Thr Asp Ala Leu Lys Thr Gly Ile Thr Ala Ala Lys Glu
            420                 425                 430         
Lys Phe Asp Ala Thr Met Lys Thr Leu Thr Ile Asp Cys Val Gln Phe
        435                 440                 445             
Gln Arg Gly Gly Lys Glu Phe Leu Lys Lys Gln Lys Leu Ser Pro Asp
    450                 455                 460                 
Ala Val Ala Gln Leu Ala Phe Gln Met Ala Phe Leu Arg Gln Tyr Gly
465                 470                 475                 480 
Gln Thr Val Ala Thr Tyr Glu Ser Cys Ser Thr Ala Ala Phe Lys His
                485                 490                 495     
Gly Arg Thr Glu Thr Ile Arg Pro Ala Ser Val Tyr Thr Lys Arg Cys
            500                 505                 510         
Ser Glu Ala Phe Val Arg Glu Pro Ser Arg His Ser Ala Gly Glu Leu
        515                 520                 525             
Gln Gln Met Met Val Glu Cys Ser Lys Tyr His Gly Gln Leu Thr Lys
    530                 535                 540                 
Glu Ala Ala Met Gly Gln Gly Phe Asp Arg His Leu Phe Ala Leu Arg
545                 550                 555                 560 
His Leu Ala Ala Ala Lys Gly Ile Ile Leu Pro Glu Leu Tyr Leu Asp
                565                 570                 575     
Pro Ala Tyr Gly Gln Ile Asn His Asn Val Leu Ser Thr Ser Thr Leu
            580                 585                 590         
Ser Ser Pro Ala Val Asn Leu Gly Gly Phe Ala Pro Val Val Ser Asp
        595                 600                 605             
Gly Phe Gly Val Gly Tyr Ala Val His Asp Asn Trp Ile Gly Cys Asn
    610                 615                 620                 
Val Ser Ser Tyr Pro Gly Arg Asn Ala Arg Glu Phe Leu Gln Cys Val
625                 630                 635                 640 
Glu Lys Ala Leu Glu Asp Met Phe Asp Ala Leu Glu Gly Lys Ser Ile
                645                 650                 655     
Lys Ser
        


<210> 12
<211> 1977
<212> DNA
<213> Homo sapiens

<400> 12
atggtgcccc gcctgctgct gcgcgcctgg ccccggggcc ccgcggttgg tccgggagcc 60
cccagtcggc ccctcagcgc cggctccggg cccggccagt acctgcagcg cagcatcgtg 120
cccaccatgc actaccagga cagcctgccc aggctgccta ttcccaaact tgaagacacc 180
attaggagat acctcagtgc acagaagcct ctcttgaatg atggccagtt caggaaaaca 240
gaacaatttt gcaagagttt tgaaaatggg attggaaaag aactgcatga gcagctggtt 300
gctctggaca aacagaataa acatacaagc tacatttcgg gaccctggtt tgatatgtac 360
ctatctgctc gagactccgt tgttctgaac tttaatccat ttatggcttt caatcctgac 420
ccaaaatctg agtataatga ccagctcacc cgggcaacca acatgactgt ttctgccatc 480
cggtttctga agacactccg ggctggcctt ctggagccag aagtgttcca cttgaaccct 540
gcaaaaagtg acactatcac cttcaagaga ctcatacgct ttgtgccttc ctctctgtcc 600
tggtatgggg cctacctggt caatgcgtat cccctggata tgtcccagta ttttcggctt 660
ttcaactcaa ctcgtttacc caaacccagt cgggatgaac tcttcactga tgacaaggcc 720
agacacctcc tggtcctaag gaaaggaaat ttttatatct ttgatgtcct ggatcaagat 780
gggaacattg tgagcccctc ggaaatccag gcacatctga agtacattct ctcagacagc 840
agccccgccc ccgagtttcc cctggcatac ctgaccagtg agaaccgaga catctgggca 900
gagctcaggc agaagctgat gagtagtggc aatgaggaga gcctgaggaa agtggactcg 960
gcagtgttct gtctctgcct agatgacttc cccattaagg accttgtcca cttgtcccac 1020
aatatgctgc atggggatgg cacaaaccgc tggtttgata aatcctttaa cctcattatc 1080
gccaaggatg gctctactgc cgtccacttt gagcactctt ggggtgatgg tgtggcagtg 1140
ctcagatttt ttaatgaagt atttaaagac agcactcaga cccctgccgt cactccacag 1200
agccagccag ctaccactga ctctactgtc acggtgcaga aactcaactt cgagctgact 1260
gatgccttaa agactggcat cacagctgct aaggaaaagt ttgatgccac catgaaaacc 1320
ctcactattg actgcgtcca gtttcagaga ggaggcaaag aattcctgaa gaagcaaaag 1380
ctgagccctg acgcagttgc ccagctggca ttccagatgg ccttcctgcg gcagtacggg 1440
cagacagtgg ccacctacga gtcctgtagc actgccgcat tcaagcacgg ccgcactgag 1500
accatccgcc cggcctccgt ctatacaaag aggtgctctg aggcctttgt cagggagccc 1560
tccaggcaca gtgctggtga gcttcagcag atgatggttg agtgctccaa gtaccatggc 1620
cagctgacca aagaagcagc aatgggccag ggctttgacc gacacttgtt tgctctgcgg 1680
catctggcag cagccaaagg gatcatcttg cctgagctct acctggaccc tgcatacggg 1740
cagataaacc acaatgtcct gtccacgagc acactgagca gcccagcagt gaaccttggg 1800
ggctttgccc ctgtggtctc tgatggcttt ggtgttgggt atgctgttca tgacaactgg 1860
ataggctgca atgtctcttc ctacccaggc cgcaatgccc gggagtttct ccaatgtgtg 1920
gagaaggcct tagaagacat gtttgatgcc ttagaaggca aatccatcaa aagttaa    1977

<210> 13
<211> 420
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Ala Gly Phe Gly Arg Cys Cys Arg Val Leu Arg Ser Ile Ser
 1               5                  10                  15      
Arg Phe His Trp Arg Ser Gln His Thr Lys Ala Asn Arg Gln Arg Glu
            20                  25                  30          
Pro Gly Leu Gly Phe Ser Phe Glu Phe Thr Glu Gln Gln Lys Glu Phe
        35                  40                  45              
Gln Ala Thr Ala Arg Lys Phe Ala Arg Glu Glu Ile Ile Pro Val Ala
    50                  55                  60                  
Ala Glu Tyr Asp Lys Thr Gly Glu Tyr Pro Val Pro Leu Ile Arg Arg
65                  70                  75                  80  
Ala Trp Glu Leu Gly Leu Met Asn Thr His Ile Pro Glu Asn Cys Gly
                85                  90                  95      
Gly Leu Gly Leu Gly Thr Phe Asp Ala Cys Leu Ile Ser Glu Glu Leu
            100                 105                 110         
Ala Tyr Gly Cys Thr Gly Val Gln Thr Ala Ile Glu Gly Asn Ser Leu
        115                 120                 125             
Gly Gln Met Pro Ile Ile Ile Ala Gly Asn Asp Gln Gln Lys Lys Lys
    130                 135                 140                 
Tyr Leu Gly Arg Met Thr Glu Glu Pro Leu Met Cys Ala Tyr Cys Val
145                 150                 155                 160 
Thr Glu Pro Gly Ala Gly Ser Asp Val Ala Gly Ile Lys Thr Lys Ala
                165                 170                 175     
Glu Lys Lys Gly Asp Glu Tyr Ile Ile Asn Gly Gln Lys Met Trp Ile
            180                 185                 190         
Thr Asn Gly Gly Lys Ala Asn Trp Tyr Phe Leu Leu Ala Arg Ser Asp
        195                 200                 205             
Pro Asp Pro Lys Ala Pro Ala Asn Lys Ala Phe Thr Gly Phe Ile Val
    210                 215                 220                 
Glu Ala Asp Thr Pro Gly Ile Gln Ile Gly Arg Lys Glu Leu Asn Met
225                 230                 235                 240 
Gly Gln Arg Cys Ser Asp Thr Arg Gly Ile Val Phe Glu Asp Val Lys
                245                 250                 255     
Val Pro Lys Glu Asn Val Leu Ile Gly Asp Gly Ala Gly Phe Lys Val
            260                 265                 270         
Ala Met Gly Ala Phe Asp Lys Thr Arg Pro Val Val Ala Ala Gly Ala
        275                 280                 285             
Val Gly Leu Ala Gln Arg Ala Leu Asp Glu Ala Thr Lys Tyr Ala Leu
    290                 295                 300                 
Glu Arg Lys Thr Phe Gly Lys Leu Leu Val Glu His Gln Ala Ile Ser
305                 310                 315                 320 
Phe Met Leu Ala Glu Met Ala Met Lys Val Glu Leu Ala Arg Met Ser
                325                 330                 335     
Tyr Gln Arg Ala Ala Trp Glu Val Asp Ser Gly Arg Arg Asn Thr Tyr
            340                 345                 350         
Tyr Ala Ser Ile Ala Lys Ala Phe Ala Gly Asp Ile Ala Asn Gln Leu
        355                 360                 365             
Ala Thr Asp Ala Val Gln Ile Leu Gly Gly Asn Gly Phe Asn Thr Glu
    370                 375                 380                 
Tyr Pro Val Glu Lys Leu Met Arg Asp Ala Lys Ile Tyr Gln Ile Tyr
385                 390                 395                 400 
Glu Gly Thr Ser Gln Ile Gln Arg Leu Ile Val Ala Arg Glu His Ile
                405                 410                 415     
Asp Lys Tyr Lys
            420 


<210> 14
<211> 1266
<212> DNA
<213> Homo sapiens

<400> 14
atggcagcgg ggttcgggcg atgctgcagg gtcctgagaa gtatttctcg ttttcattgg 60
agatcacagc atacaaaagc caatcgacaa cgtgaaccag gattaggatt tagttttgag 120
ttcaccgaac agcagaaaga atttcaagct actgctcgta aatttgccag agaggaaatc 180
atcccagtgg ctgcagaata tgataaaact ggtgaatatc cagtccccct aattagaaga 240
gcctgggaac ttggtttaat gaacacacac attccagaga actgtggagg tcttggactt 300
ggaacttttg atgcttgttt aattagtgaa gaattggctt atggatgtac aggggttcag 360
actgctattg aaggaaattc tttggggcaa atgcctatta ttattgctgg aaatgatcaa 420
caaaagaaga agtatttggg gagaatgact gaggagccat tgatgtgtgc ttattgtgta 480
acagaacctg gagcaggctc tgatgtagct ggtataaaga ccaaagcaga aaagaaagga 540
gatgagtata ttattaatgg tcagaagatg tggataacca acggaggaaa agctaattgg 600
tattttttat tggcacgttc tgatccagat cctaaagctc ctgctaataa agcctttact 660
ggattcattg tggaagcaga taccccagga attcagattg ggagaaagga attaaacatg 720
ggccagcgat gttcagatac tagaggaatt gtcttcgaag atgtgaaagt gcctaaagaa 780
aatgttttaa ttggtgacgg agctggtttc aaagttgcaa tgggagcttt tgataaaacc 840
agacctgtag tagctgctgg tgctgttgga ttagcacaaa gagctttgga tgaagctacc 900
aagtatgccc tggaaaggaa aactttcgga aagctacttg tagagcacca agcaatatca 960
tttatgctgg ctgaaatggc aatgaaagtt gaactagcta gaatgagtta ccagagagca 1020
gcttgggagg ttgattctgg tcgtcgaaat acctattatg cttctattgc aaaggcattt 1080
gctggagata ttgcaaatca gttagctact gatgctgtgc agatacttgg aggcaatgga 1140
tttaatacag aatatcctgt agaaaaacta atgagggatg ccaaaatcta tcagatttat 1200
gaaggtactt cacaaattca aagacttatt gtagcccgtg aacacattga caagtacaaa 1260
aattaa                                                            1266

<210> 15
<211> 1276
<212> PRT
<213> Homo sapiens

<400> 15
Met Arg Ser Lys Ala Arg Ala Arg Lys Leu Ala Lys Ser Asp Gly Asp
 1               5                  10                  15      
Val Val Asn Asn Met Tyr Glu Pro Asn Arg Asp Leu Leu Ala Ser His
            20                  25                  30          
Ser Ala Glu Asp Glu Ala Glu Asp Ser Ala Met Ser Pro Ile Pro Val
        35                  40                  45              
Gly Ser Pro Pro Pro Phe Pro Thr Ser Glu Asp Phe Thr Pro Lys Glu
    50                  55                  60                  
Gly Ser Pro Tyr Glu Ala Pro Val Tyr Ile Pro Glu Asp Ile Pro Ile
65                  70                  75                  80  
Pro Ala Asp Phe Glu Leu Arg Glu Ser Ser Ile Pro Gly Ala Gly Leu
                85                  90                  95      
Gly Val Trp Ala Lys Arg Lys Met Glu Ala Gly Glu Arg Leu Gly Pro
            100                 105                 110         
Cys Val Val Val Pro Arg Ala Ala Ala Lys Glu Thr Asp Phe Gly Trp
        115                 120                 125             
Glu Gln Ile Leu Thr Asp Val Glu Val Ser Pro Gln Glu Gly Cys Ile
    130                 135                 140                 
Thr Lys Ile Ser Glu Asp Leu Gly Ser Glu Lys Phe Cys Val Asp Ala
145                 150                 155                 160 
Asn Gln Ala Gly Ala Gly Ser Trp Leu Lys Tyr Ile Arg Val Ala Cys
                165                 170                 175     
Ser Cys Asp Asp Gln Asn Leu Thr Met Cys Gln Ile Ser Glu Gln Val
            180                 185                 190         
Ile Tyr Tyr Lys Val Ile Lys Asp Ile Glu Pro Gly Glu Glu Leu Leu
        195                 200                 205             
Val His Val Lys Glu Gly Val Tyr Pro Leu Gly Thr Val Pro Pro Gly
    210                 215                 220                 
Leu Asp Glu Glu Pro Thr Phe Arg Cys Asp Glu Cys Asp Glu Leu Phe
225                 230                 235                 240 
Gln Ser Lys Leu Asp Leu Arg Arg His Lys Lys Tyr Thr Cys Gly Ser
                245                 250                 255     
Val Gly Ala Ala Leu Tyr Glu Gly Leu Ala Glu Glu Leu Lys Pro Glu
            260                 265                 270         
Gly Leu Gly Gly Gly Ser Gly Gln Ala His Glu Cys Lys Asp Cys Glu
        275                 280                 285             
Arg Met Phe Pro Asn Lys Tyr Ser Leu Glu Gln His Met Val Ile His
    290                 295                 300                 
Thr Glu Glu Arg Glu Tyr Lys Cys Asp Gln Cys Pro Lys Ala Phe Asn
305                 310                 315                 320 
Trp Lys Ser Asn Phe Ile Arg His Gln Met Ser His Asp Ser Gly Lys
                325                 330                 335     
Arg Phe Glu Cys Glu Asn Cys Val Lys Val Phe Thr Asp Pro Ser Asn
            340                 345                 350         
Leu Gln Arg His Ile Arg Ser Gln His Val Gly Ala Arg Ala His Ala
        355                 360                 365             
Cys Pro Asp Cys Gly Lys Thr Phe Ala Thr Ser Ser Gly Leu Lys Gln
    370                 375                 380                 
His Lys His Ile His Ser Thr Val Lys Pro Phe Ile Cys Glu Val Cys
385                 390                 395                 400 
His Lys Ser Tyr Thr Gln Phe Ser Asn Leu Cys Arg His Lys Arg Met
                405                 410                 415     
His Ala Asp Cys Arg Thr Gln Ile Lys Cys Lys Asp Cys Gly Gln Met
            420                 425                 430         
Phe Ser Thr Thr Ser Ser Leu Asn Lys His Arg Arg Phe Cys Glu Gly
        435                 440                 445             
Lys Asn His Tyr Thr Pro Gly Gly Ile Phe Ala Pro Gly Leu Pro Leu
    450                 455                 460                 
Thr Pro Ser Pro Met Met Asp Lys Ala Lys Pro Ser Pro Ser Leu Asn
465                 470                 475                 480 
His Ala Ser Leu Gly Phe Asn Glu Tyr Phe Pro Tyr Arg Pro His Pro
                485                 490                 495     
Gly Ser Leu Pro Phe Ser Thr Ala Pro Pro Thr Phe Pro Ala Leu Thr
            500                 505                 510         
Pro Gly Phe Pro Gly Ile Phe Pro Pro Ser Leu Tyr Pro Arg Pro Pro
        515                 520                 525             
Leu Leu Pro Pro Thr Ser Leu Leu Lys Ser Pro Leu Asn His Thr Gln
    530                 535                 540                 
Asp Ala Lys Leu Pro Ser Pro Leu Gly Asn Pro Ala Leu Pro Leu Val
545                 550                 555                 560 
Ser Ala Val Ser Asn Ser Ser Gln Gly Thr Thr Ala Ala Ala Gly Pro
                565                 570                 575     
Glu Glu Lys Phe Glu Ser Arg Leu Glu Asp Ser Cys Val Glu Lys Leu
            580                 585                 590         
Lys Thr Arg Ser Ser Asp Met Ser Asp Gly Ser Asp Phe Glu Asp Val
        595                 600                 605             
Asn Thr Thr Thr Gly Thr Asp Leu Asp Thr Thr Thr Gly Thr Gly Ser
    610                 615                 620                 
Asp Leu Asp Ser Asp Val Asp Ser Asp Pro Asp Lys Asp Lys Gly Lys
625                 630                 635                 640 
Gly Lys Ser Ala Glu Gly Gln Pro Lys Phe Gly Gly Gly Leu Ala Pro
                645                 650                 655     
Pro Gly Ala Pro Asn Ser Val Ala Glu Val Pro Val Phe Tyr Ser Gln
            660                 665                 670         
His Ser Phe Phe Pro Pro Pro Asp Glu Gln Leu Leu Thr Ala Thr Gly
        675                 680                 685             
Ala Ala Gly Asp Ser Ile Lys Ala Ile Ala Ser Ile Ala Glu Lys Tyr
    690                 695                 700                 
Phe Gly Pro Gly Phe Met Gly Met Gln Glu Lys Lys Leu Gly Ser Leu
705                 710                 715                 720 
Pro Tyr His Ser Ala Phe Pro Phe Gln Phe Leu Pro Asn Phe Pro His
                725                 730                 735     
Ser Leu Tyr Pro Phe Thr Asp Arg Ala Leu Ala His Asn Leu Leu Val
            740                 745                 750         
Lys Ala Glu Pro Lys Ser Pro Arg Asp Ala Leu Lys Val Gly Gly Pro
        755                 760                 765             
Ser Ala Glu Cys Pro Phe Asp Leu Thr Thr Lys Pro Lys Asp Val Lys
    770                 775                 780                 
Pro Ile Leu Pro Met Pro Lys Gly Pro Ser Ala Pro Ala Ser Gly Glu
785                 790                 795                 800 
Glu Gln Pro Leu Asp Leu Ser Ile Gly Ser Arg Ala Arg Ala Ser Gln
                805                 810                 815     
Asn Gly Gly Gly Arg Glu Pro Arg Lys Asn His Val Tyr Gly Glu Arg
            820                 825                 830         
Lys Leu Gly Ala Gly Glu Gly Leu Pro Gln Val Cys Pro Ala Arg Met
        835                 840                 845             
Pro Gln Gln Pro Pro Leu His Tyr Ala Lys Pro Ser Pro Phe Phe Met
    850                 855                 860                 
Asp Pro Ile Tyr Arg Val Glu Lys Arg Lys Val Thr Asp Pro Val Gly
865                 870                 875                 880 
Ala Leu Lys Glu Lys Tyr Leu Arg Pro Ser Pro Leu Leu Phe His Pro
                885                 890                 895     
Gln Met Ser Ala Ile Glu Thr Met Thr Glu Lys Leu Glu Ser Phe Ala
            900                 905                 910         
Ala Met Lys Ala Asp Ser Gly Ser Ser Leu Gln Pro Leu Pro His His
        915                 920                 925             
Pro Phe Asn Phe Arg Ser Pro Pro Pro Thr Leu Ser Asp Pro Ile Leu
    930                 935                 940                 
Arg Lys Gly Lys Glu Arg Tyr Thr Cys Arg Tyr Cys Gly Lys Ile Phe
945                 950                 955                 960 
Pro Arg Ser Ala Asn Leu Thr Arg His Leu Arg Thr His Thr Gly Glu
                965                 970                 975     
Gln Pro Tyr Arg Cys Lys Tyr Cys Asp Arg Ser Phe Ser Ile Ser Ser
            980                 985                 990         
Asn Leu Gln Arg His Val Arg Asn Ile His Asn Lys Glu Lys Pro Phe
        995                 1000                1005            
Lys Cys His Leu Cys Asn Arg Cys Phe Gly Gln Gln Thr Asn Leu Asp
    1010                1015                1020                
Arg His Leu Lys Lys His Glu His Glu Asn Ala Pro Val Ser Gln His
1025                1030                1035               1040 
Pro Gly Val Leu Thr Asn His Leu Gly Thr Ser Ala Ser Ser Pro Thr
                1045                1050                1055    
Ser Glu Ser Asp Asn His Ala Leu Leu Asp Glu Lys Glu Asp Ser Tyr
            1060                1065                1070        
Phe Ser Glu Ile Arg Asn Phe Ile Ala Asn Ser Glu Met Asn Gln Ala
        1075                1080                1085            
Ser Thr Arg Thr Glu Lys Arg Ala Asp Met Gln Ile Val Asp Gly Ser
    1090                1095                1100                
Ala Gln Cys Pro Gly Leu Ala Ser Glu Lys Gln Glu Asp Val Glu Glu
1105                1110                1115               1120 
Glu Asp Asp Asp Asp Leu Glu Glu Asp Asp Glu Asp Ser Leu Ala Gly
                1125                1130                1135    
Lys Ser Gln Asp Asp Thr Val Ser Pro Ala Pro Glu Pro Gln Ala Ala
            1140                1145                1150        
Tyr Glu Asp Glu Glu Asp Glu Glu Pro Ala Ala Ser Leu Ala Val Gly
        1155                1160                1165            
Phe Asp His Thr Arg Arg Cys Ala Glu Asp His Glu Gly Gly Leu Leu
    1170                1175                1180                
Ala Leu Glu Pro Met Pro Thr Phe Gly Lys Gly Leu Asp Leu Arg Arg
1185                1190                1195               1200 
Ala Ala Glu Glu Ala Phe Glu Val Lys Asp Val Leu Asn Ser Thr Leu
                1205                1210                1215    
Asp Ser Glu Ala Leu Lys His Thr Leu Cys Arg Gln Ala Lys Asn Gln
            1220                1225                1230        
Ala Tyr Ala Met Met Leu Ser Leu Ser Glu Asp Thr Pro Leu His Thr
        1235                1240                1245            
Pro Ser Gln Gly Ser Leu Asp Ala Trp Leu Lys Val Thr Gly Ala Thr
    1250                1255                1260                
Ser Glu Ser Gly Ala Phe His Pro Ile Asn His Leu
1265                1270                1275    


<210> 16
<211> 3831
<212> DNA
<213> Homo sapiens

<400> 16
atgcgatcca aggcgagggc gaggaagcta gccaaaagtg acggtgacgt tgtaaataat 60
atgtatgagc ccaaccggga cctgctggcc agccacagcg cggaggacga ggccgaggac 120
agtgccatgt cgcccatccc cgtggggtca ccgcccccct tccccaccag cgaggacttc 180
acccccaagg agggctcgcc gtacgaggcc cctgtctaca ttcctgaaga cattccgatc 240
ccagcagact tcgagctccg agagtcctcc atcccagggg ctggcctggg ggtctgggcc 300
aagaggaaga tggaagccgg ggagaggctg ggcccctgcg tggtggtgcc ccgggcggcg 360
gcaaaggaga cagacttcgg atgggagcaa atactgacgg acgtggaagt gtcgccccag 420
gaaggctgca tcacaaagat ctccgaagac ctgggcagtg agaagttctg cgtggatgca 480
aatcaggcgg gggctggcag ctggctcaag tacatccgtg tggcgtgctc ctgcgatgac 540
cagaacctca ccatgtgtca gatcagtgag caggtaattt actataaagt cattaaggac 600
attgagccag gtgaggagct gctggtgcac gtgaaggaag gcgtctaccc cctgggcaca 660
gtgccgcccg gcctggacga ggagcccacg ttccgctgtg acgagtgtga cgaactcttc 720
cagtccaagc tggacctgcg gcgccataag aagtacacgt gtggctcagt gggggctgcg 780
ctctacgagg gcctggctga ggagctcaag cccgagggcc ttggcggtgg cagcggccaa 840
gcccacgagt gcaaggactg cgagcggatg ttccccaaca agtacagcct ggagcagcac 900
atggtcatcc acacggagga gcgcgagtac aaatgcgacc agtgtcccaa ggccttcaac 960
tggaagtcca acttcatccg ccaccagatg tcccacgaca gcggcaaacg cttcgaatgt 1020
gaaaactgcg tgaaggtgtt cacggacccc agcaaccttc agcggcacat ccgctcgcag 1080
cacgtgggcg ctcgggccca cgcctgcccc gactgcggga agaccttcgc cacgtcctcc 1140
ggcctcaagc agcacaagca tatccacagc acggtgaagc ctttcatatg tgaggtctgc 1200
cacaagtcct acacgcagtt ctccaacctg tgccggcaca agcggatgca cgccgactgc 1260
cgcacgcaga tcaagtgcaa ggactgtggc cagatgttca gcactacctc ctccctcaac 1320
aagcaccggc gcttctgcga gggcaagaac cattacacgc cgggcggcat ctttgccccg 1380
ggcctgccct tgacccccag ccccatgatg gacaaggcaa aaccctcccc cagcctcaat 1440
cacgccagcc tgggcttcaa cgagtacttt ccctacaggc cgcacccggg gagcctgccc 1500
ttctccacgg cgcctcccac gttccccgca ctcacccccg gcttcccggg catcttccct 1560
ccatccttgt acccccggcc gcctctgcta cctcccacat cgctgctcaa gagccccctg 1620
aaccacaccc aggacgccaa gctccccagt cccctgggga acccagccct gcccctggtc 1680
tccgccgtca gcaacagcag ccagggcacg acggcagctg cggggcccga ggagaagttc 1740
gagagccgcc tggaggactc ctgtgtggag aagctgaaga ccaggagcag cgacatgtcg 1800
gacggcagtg actttgagga cgtcaacacc accacgggga ccgacctgga cacgaccacg 1860
gggacgggct cggacctgga cagcgacgtg gacagcgacc ctgacaagga caagggcaag 1920
ggcaagtccg ccgagggcca gcccaagttt gggggcggct tggcgccccc gggggccccg 1980
aacagcgtgg ccgaggtgcc tgtcttctat tcccagcact cattcttccc gccacccgac 2040
gagcagctgc tgactgcaac gggcgccgcc ggggactcca tcaaggccat cgcatccatt 2100
gccgagaagt actttggccc cggcttcatg gggatgcagg agaagaagct gggctcgctc 2160
ccctaccact cggcgttccc cttccagttc ctgcccaact tcccccactc cctttacccc 2220
ttcacggacc gagccctcgc ccacaacttg ctggtcaagg ccgagccaaa gtcaccccgg 2280
gacgccctca aggtgggcgg ccccagtgcc gagtgcccct ttgatctcac caccaagccc 2340
aaagacgtga agcccatcct gcccatgccc aagggcccct cggcccccgc atccggcgag 2400
gagcagccgc tggacctgag catcggcagc cgggcccgtg ccagccaaaa cggcggcggg 2460
cgggagcccc gcaagaacca cgtctatggg gaacgcaagc tgggcgccgg cgaggggctg 2520
ccccaggtgt gcccggcgcg gatgccccag cagcccccgc tccactacgc caagccctcg 2580
cccttcttca tggaccccat ctacagggta gaaaagcgga aggtcacaga ccccgtggga 2640
gccctgaagg agaagtacct gcggccgtcc ccgctgctct tccaccccca gatgtcagcc 2700
atagagacca tgacagagaa gctggagagc tttgcagcca tgaaggcgga ctcgggcagc 2760
tccctgcagc ccctccccca ccaccccttc aacttccggt ccccaccccc aacgctctcc 2820
gaccccatcc tcaggaaggg caaggagcga tacacgtgca ggtactgtgg gaagatcttc 2880
cccagatcag ccaatctcac cagacacctg aggacgcaca ctggggagca gccgtacagg 2940
tgtaagtact gcgaccgctc cttcagcatc tcttcgaacc tccagcggca cgtccggaac 3000
atccacaaca aggagaagcc tttcaagtgc cacctgtgca accgctgctt cgggcagcag 3060
accaacctgg accggcacct caagaagcac gagcacgaga acgcaccagt gagccagcac 3120
cccggggtcc tcacgaacca cctggggacc agcgcgtcct ctcccacctc agagtcggac 3180
aaccacgcac ttttagacga gaaagaagac tcttatttct cggaaatcag aaactttatt 3240
gccaatagtg agatgaacca agcatcaacg cgaacagaga aacgggcgga catgcagatc 3300
gtggacggca gtgcccagtg tccaggccta gccagtgaga agcaggagga cgtggaggag 3360
gaggacgacg atgacctgga ggaggacgat gaggacagcc tggccgggaa gtcgcaggat 3420
gacaccgtgt cccccgcacc cgagccccag gccgcctacg aggatgagga ggatgaggag 3480
ccagccgcct ccctggccgt gggctttgac cacacccgaa ggtgtgctga ggaccacgaa 3540
ggcggtctgt tagctttgga gccgatgccg acttttggga aggggctgga cctccgcaga 3600
gcagctgagg aagcatttga agttaaagat gtgcttaatt ccaccttaga ttctgaggct 3660
ttaaaacata cactgtgcag gcaggctaag aaccaggcat atgcaatgat gctgtccctt 3720
tccgaagaca ctcctctcca caccccctcc cagggttctc tggacgcttg gttgaaggtc 3780
actggagcca cgtcggagtc tggagcattt caccccatca accacctctg a          3831

<210> 17
<211> 358
<212> PRT
<213> Homo sapiens

<400> 17
Met Glu Ser Ala Asp Phe Tyr Glu Ala Glu Pro Arg Pro Pro Met Ser
 1               5                  10                  15      
Ser His Leu Gln Ser Pro Pro His Ala Pro Ser Ser Ala Ala Phe Gly
            20                  25                  30          
Phe Pro Arg Gly Ala Gly Pro Ala Gln Pro Pro Ala Pro Pro Ala Ala
        35                  40                  45              
Pro Glu Pro Leu Gly Gly Ile Cys Glu His Glu Thr Ser Ile Asp Ile
    50                  55                  60                  
Ser Ala Tyr Ile Asp Pro Ala Ala Phe Asn Asp Glu Phe Leu Ala Asp
65                  70                  75                  80  
Leu Phe Gln His Ser Arg Gln Gln Glu Lys Ala Lys Ala Ala Val Gly
                85                  90                  95      
Pro Thr Gly Gly Gly Gly Gly Gly Asp Phe Asp Tyr Pro Gly Ala Pro
            100                 105                 110         
Ala Gly Pro Gly Gly Ala Val Met Pro Gly Gly Ala His Gly Pro Pro
        115                 120                 125             
Pro Gly Tyr Gly Cys Ala Ala Ala Gly Tyr Leu Asp Gly Arg Leu Glu
    130                 135                 140                 
Pro Leu Tyr Glu Arg Val Gly Ala Pro Ala Leu Arg Pro Leu Val Ile
145                 150                 155                 160 
Lys Gln Glu Pro Arg Glu Glu Asp Glu Ala Lys Gln Leu Ala Leu Ala
                165                 170                 175     
Gly Leu Phe Pro Tyr Gln Pro Pro Pro Pro Pro Pro Pro Ser His Pro
            180                 185                 190         
His Pro His Pro Pro Pro Ala His Leu Ala Ala Pro His Leu Gln Phe
        195                 200                 205             
Gln Ile Ala His Cys Gly Gln Thr Thr Met His Leu Gln Pro Gly His
    210                 215                 220                 
Pro Thr Pro Pro Pro Thr Pro Val Pro Ser Pro His Pro Ala Pro Ala
225                 230                 235                 240 
Leu Gly Ala Ala Gly Leu Pro Gly Pro Gly Ser Ala Leu Lys Gly Leu
                245                 250                 255     
Gly Ala Ala His Pro Asp Leu Arg Ala Ser Gly Gly Ser Gly Ala Gly
            260                 265                 270         
Lys Ala Lys Lys Ser Val Asp Lys Asn Ser Asn Glu Tyr Arg Val Arg
        275                 280                 285             
Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser Arg Asp Lys Ala Lys
    290                 295                 300                 
Gln Arg Asn Val Glu Thr Gln Gln Lys Val Leu Glu Leu Thr Ser Asp
305                 310                 315                 320 
Asn Asp Arg Leu Arg Lys Arg Val Glu Gln Leu Ser Arg Glu Leu Asp
                325                 330                 335     
Thr Leu Arg Gly Ile Phe Arg Gln Leu Pro Glu Ser Ser Leu Val Lys
            340                 345                 350         
Ala Met Gly Asn Cys Ala
        355             


<210> 18
<211> 1077
<212> DNA
<213> Homo sapiens

<400> 18
atggagtcgg ccgacttcta cgaggcggag ccgcggcccc cgatgagcag ccacctgcag 60
agccccccgc acgcgcccag cagcgccgcc ttcggctttc cccggggcgc gggccccgcg 120
cagcctcccg ccccacctgc cgccccggag ccgctgggcg gcatctgcga gcacgagacg 180
tccatcgaca tcagcgccta catcgacccg gccgccttca acgacgagtt cctggccgac 240
ctgttccagc acagccggca gcaggagaag gccaaggcgg ccgtgggccc cacgggcggc 300
ggcggcggcg gcgactttga ctacccgggc gcgcccgcgg gccccggcgg cgccgtcatg 360
cccgggggag cgcacgggcc cccgcccggc tacggctgcg cggccgccgg ctacctggac 420
ggcaggctgg agcccctgta cgagcgcgtc ggggcgccgg cgctgcggcc gctggtgatc 480
aagcaggagc cccgcgagga ggatgaagcc aagcagctgg cgctggccgg cctcttccct 540
taccagccgc cgccgccgcc gccgccctcg cacccgcacc cgcacccgcc gcccgcgcac 600
ctggccgccc cgcacctgca gttccagatc gcgcactgcg gccagaccac catgcacctg 660
cagcccggtc accccacgcc gccgcccacg cccgtgccca gcccgcaccc cgcgcccgcg 720
ctcggtgccg ccggcctgcc gggccctggc agcgcgctca aggggctggg cgccgcgcac 780
cccgacctcc gcgcgagtgg cggcagcggc gcgggcaagg ccaagaagtc ggtggacaag 840
aacagcaacg agtaccgggt gcggcgcgag cgcaacaaca tcgcggtgcg caagagccgc 900
gacaaggcca agcagcgcaa cgtggagacg cagcagaagg tgctggagct gaccagtgac 960
aatgaccgcc tgcgcaagcg ggtggaacag ctgagccgcg aactggacac gctgcggggc 1020
atcttccgcc agctgccaga gagctccttg gtcaaggcca tgggcaactg cgcgtga    1077

<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 19
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  10      


<210> 20
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 20
Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg
 1               5                  10          


<210> 21
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 21
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu
 1               5                  10                  15      
Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu
            20                  25          


<210> 22
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 22
Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala
 1               5                  10                  15      
Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu
            20                  25                  30          
Ala
    


<210> 23
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 23
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys
 1               5                  10                  15      


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 24
Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  


<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 25
Arg Lys Lys Arg Arg Gln Arg Arg
 1               5              


<210> 26
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 26
Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala
 1               5                  10      


<210> 27
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 27
Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg
 1               5                  10      


<210> 28
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide

<400> 28
Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg
 1               5                  10      


<210> 29
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 29
agcttgctgt cactcctcta ca                                          22

<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 30
tgaggaaagg gttgaccttg                                             20

<210> 31
<211> 468
<212> PRT
<213> Homo sapiens

<400> 31
Met Val Asp Thr Glu Ser Pro Leu Cys Pro Leu Ser Pro Leu Glu Ala
 1               5                  10                  15      
Gly Asp Leu Glu Ser Pro Leu Ser Glu Glu Phe Leu Gln Glu Met Gly
            20                  25                  30          
Asn Ile Gln Glu Ile Ser Gln Ser Ile Gly Glu Asp Ser Ser Gly Ser
        35                  40                  45              
Phe Gly Phe Thr Glu Tyr Gln Tyr Leu Gly Ser Cys Pro Gly Ser Asp
    50                  55                  60                  
Gly Ser Val Ile Thr Asp Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser
65                  70                  75                  80  
Val Thr Tyr Pro Val Val Pro Gly Ser Val Asp Glu Ser Pro Ser Gly
                85                  90                  95      
Ala Leu Asn Ile Glu Cys Arg Ile Cys Gly Asp Lys Ala Ser Gly Tyr
            100                 105                 110         
His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg
        115                 120                 125             
Thr Ile Arg Leu Lys Leu Val Tyr Asp Lys Cys Asp Arg Ser Cys Lys
    130                 135                 140                 
Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys Arg Phe His Lys
145                 150                 155                 160 
Cys Leu Ser Val Gly Met Ser His Asn Ala Ile Arg Phe Gly Arg Met
                165                 170                 175     
Pro Arg Ser Glu Lys Ala Lys Leu Lys Ala Glu Ile Leu Thr Cys Glu
            180                 185                 190         
His Asp Ile Glu Asp Ser Glu Thr Ala Asp Leu Lys Ser Leu Ala Lys
        195                 200                 205             
Arg Ile Tyr Glu Ala Tyr Leu Lys Asn Phe Asn Met Asn Lys Val Lys
    210                 215                 220                 
Ala Arg Val Ile Leu Ser Gly Lys Ala Ser Asn Asn Pro Pro Phe Val
225                 230                 235                 240 
Ile His Asp Met Glu Thr Leu Cys Met Ala Glu Lys Thr Leu Val Ala
                245                 250                 255     
Lys Leu Val Ala Asn Gly Ile Gln Asn Lys Glu Ala Glu Val Arg Ile
            260                 265                 270         
Phe His Cys Cys Gln Cys Thr Ser Val Glu Thr Val Thr Glu Leu Thr
        275                 280                 285             
Glu Phe Ala Lys Ala Ile Pro Gly Phe Ala Asn Leu Asp Leu Asn Asp
    290                 295                 300                 
Gln Val Thr Leu Leu Lys Tyr Gly Val Tyr Glu Ala Ile Phe Ala Met
305                 310                 315                 320 
Leu Ser Ser Val Met Asn Lys Asp Gly Met Leu Val Ala Tyr Gly Asn
                325                 330                 335     
Gly Phe Ile Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Cys
            340                 345                 350         
Asp Ile Met Glu Pro Lys Phe Asp Phe Ala Met Lys Phe Asn Ala Leu
        355                 360                 365             
Glu Leu Asp Asp Ser Asp Ile Ser Leu Phe Val Ala Ala Ile Ile Cys
    370                 375                 380                 
Cys Gly Asp Arg Pro Gly Leu Leu Asn Val Gly His Ile Glu Lys Met
385                 390                 395                 400 
Gln Glu Gly Ile Val His Val Leu Arg Leu His Leu Gln Ser Asn His
                405                 410                 415     
Pro Asp Asp Ile Phe Leu Phe Pro Lys Leu Leu Gln Lys Met Ala Asp
            420                 425                 430         
Leu Arg Gln Leu Val Thr Glu His Ala Gln Leu Val Gln Ile Ile Lys
        435                 440                 445             
Lys Thr Glu Ser Asp Ala Ala Leu His Pro Leu Leu Gln Glu Ile Tyr
    450                 455                 460                 
Arg Asp Met Tyr
465             

