                         SEQUENCE LISTING

<110>  Wisconsin Alumni Research Foundation
       Striker, Robert
       Ansari, Israr
 
<120>  COMPOSITIONS AND METHODS FOR PREDICTING HCV SUSCEPTIBILITY TO 
       ANTIVIRAL AGENTS

<130>  960296.01271

<150>  US 61/386,306
<151>  2010-09-24

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  3011
<212>  PRT
<213>  Hepatitis C virus

<400>  1

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Met Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Gly Arg Thr Thr Ala Gly Leu Val 
385                 390                 395                 400 


Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Leu 
465                 470                 475                 480 


Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Met 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Ile Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Arg Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Phe Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Met Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Val Glu Ala Gln Leu His Val Trp Val Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Thr Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ile Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Ile 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Gln 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Val Gln  Ile Val Ser Thr Ala  Thr Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Gln Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ser Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Val  Thr Val Ser His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Val Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ser Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Phe Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Phe Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Pro Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Ile Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ala Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Gln Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Ile Thr Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Val Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Gly Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Ala Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Arg Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Arg  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Lys Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Arg  Val Gly Asp Phe His  Tyr Val Ser 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Ile Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Lys Ala Thr Cys  Thr Ala Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Arg  Phe Ala Arg 
    2270                 2275                 2280             


Ala Leu  Pro Val Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Thr  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Arg  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Val Leu  Thr Glu Ser Thr Leu  Ser Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asn Thr  Thr Thr Ser Ser Glu  Pro Ala Pro 
    2360                 2365                 2370             


Ser Gly  Cys Pro Pro Asp Ser  Asp Val Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Gly Ala Asp Thr Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Ser  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Ala His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Ser Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asn Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Ser Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Asp Ile  Tyr His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Phe Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


<210>  2
<211>  3010
<212>  PRT
<213>  Hepatitis C virus

<400>  2

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Leu Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ala 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Gly 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Thr Met Ala Lys Asn Thr Leu Gly Ile Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ser Ser Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Val His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Ser Pro Ile Asp Ala 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Asn Glu Ser His Ser Ser 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ala Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Ile Gly Asn 
                565                 570                 575     


Lys Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Val Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Val Ala Gly Ala His Gly Ile Leu Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Ala Ala Trp Tyr Ile Lys Gly Arg Leu Val Pro 
    770                 775                 780                 


Gly Ala Ala Tyr Ala Leu Tyr Gly Val Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Pro Arg Ala Tyr Ala Met Asp Arg Glu Met Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Ala Val Phe Val Gly Leu Ile Leu Leu Thr Leu Ser 
            820                 825                 830         


Pro His Tyr Lys Leu Phe Leu Ala Arg Leu Ile Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Ile Thr Arg Ala Glu Ala His Leu Gln Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Thr Cys Ala Ile 
865                 870                 875                 880 


His Pro Glu Leu Ile Phe Thr Ile Thr Lys Ile Leu Leu Ala Ile Leu 
                885                 890                 895     


Gly Pro Leu Met Val Leu Gln Ala Gly Ile Thr Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Ala His Gly Leu Ile Arg Ala Cys Met Leu Val Arg Lys Val 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Leu Met Lys Leu Ala Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asp His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Ala Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Asp Met Glu Thr Lys Val Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Leu Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  His Leu Gly Pro Ala  Asp Ser Leu Glu Gly  Gln Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ser Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Arg Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Val Gln  Val Val Ser Thr Ala  Thr Gln Ser 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Val Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Ser Lys Thr Leu  Ala Gly Pro Lys Gly  Pro Ile Thr 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Gln Asp Leu Val Gly  Trp Gln Ala 
    1100                 1105                 1110             


Pro Pro  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Val 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ser 
    1160                 1165                 1170             


Gly His  Ala Val Gly Ile Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Val Pro Val Glu Ser  Met Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Thr Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Ile Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ala Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ser 
    1310                 1315                 1320             


Thr Thr  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Val  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Ser Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Ile Glu 
    1370                 1375                 1380             


Thr Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Ser Gly Leu  Gly Leu Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Ile Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Phe Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Phe Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Val Pro Gln Asp  Ala Val Ser Arg Ser  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Arg  Met Gly Ile Tyr Arg  Phe Val Thr 
    1490                 1495                 1500             


Pro Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Ser Val Arg Leu Arg  Ala Tyr Leu Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Ser  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ala Gly  Asp Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Ile Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Thr Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Ala Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ala Tyr Cys Leu  Thr Thr Gly Ser Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Ile Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ala Ser 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Gln Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Ile Gly Leu  Leu Gln Thr Ala Thr  Lys Gln Ala 
    1730                 1735                 1740             


Glu Ala  Ala Ala Pro Val Val  Glu Ser Lys Trp Arg  Thr Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ser Ile Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Gln His  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Pro Pro Ser Ala  Ala Ser Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Ile Ala  Gly Ala Ala Val Gly  Ser Ile Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Val Met Ser  Gly Glu Met Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Gln Ile Leu Ser Ser  Leu Thr Ile 
    1940                 1945                 1950             


Thr Gln  Leu Leu Lys Arg Leu  His Gln Trp Ile Asn  Glu Asp Cys 
    1955                 1960                 1965             


Ser Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Val  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Thr Val Leu Thr Asp  Phe Lys Thr Trp Leu  Gln Ser Lys 
    1985                 1990                 1995             


Leu Leu  Pro Arg Leu Pro Gly  Val Pro Phe Phe Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  Gln Thr Thr 
    2015                 2020                 2025             


Cys Pro  Cys Gly Ala Gln Ile  Thr Gly His Val Lys  Asn Gly Ser 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Arg  Thr Cys Ser Asn Thr  Trp His Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Ser 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Ser Arg  Ala Leu Trp Arg Val  Ala Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Val Thr Arg  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Val  Lys Cys Pro Cys Gln  Val Pro Ala 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Val  Asp Gly Val Arg Leu  His Arg Tyr 
    2120                 2125                 2130             


Ala Pro  Ala Cys Lys Pro Leu  Leu Arg Glu Glu Val  Thr Phe Leu 
    2135                 2140                 2145             


Val Gly  Leu Asn Gln Tyr Leu  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Thr  Ala Lys Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Leu Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Lys Ala Thr Cys  Thr Thr Arg His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Asp  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Glu Pro Leu Gln  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Arg Ser Arg Lys  Phe Pro Arg 
    2270                 2275                 2280             


Ala Met  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Leu 
    2285                 2290                 2295             


Glu Ser  Trp Lys Asp Pro Asp  Tyr Val Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Ala Lys  Ala Pro Pro Ile Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Lys  Arg Thr Val Val Leu  Ser Glu Ser Thr Val  Ser Ser Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Thr Phe Gly Ser Ser  Glu Ser Ser 
    2345                 2350                 2355             


Ala Val  Asp Ser Gly Thr Ala  Thr Ala Ser Pro Asp  Gln Pro Ser 
    2360                 2365                 2370             


Asp Asp  Gly Asp Ala Gly Ser  Asp Val Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Glu  Glu Ala Ser Glu Asp  Val Val Cys 
    2405                 2410                 2415             


Cys Ser  Met Ser Tyr Thr Trp  Thr Gly Ala Leu Ile  Thr Pro Cys 
    2420                 2425                 2430             


Ala Ala  Glu Glu Thr Lys Leu  Pro Ile Asn Ala Leu  Ser Asn Ser 
    2435                 2440                 2445             


Leu Leu  Arg His His Asn Leu  Val Tyr Ala Thr Thr  Ser Arg Ser 
    2450                 2455                 2460             


Ala Ser  Leu Arg Gln Lys Lys  Val Thr Phe Asp Arg  Leu Gln Val 
    2465                 2470                 2475             


Leu Asp  Asp His Tyr Arg Asp  Val Leu Lys Glu Met  Lys Ala Lys 
    2480                 2485                 2490             


Ala Ser  Thr Val Lys Ala Lys  Leu Leu Ser Val Glu  Glu Ala Cys 
    2495                 2500                 2505             


Lys Leu  Thr Pro Pro His Ser  Ala Arg Ser Lys Phe  Gly Tyr Gly 
    2510                 2515                 2520             


Ala Lys  Asp Val Arg Asn Leu  Ser Ser Lys Ala Val  Asn His Ile 
    2525                 2530                 2535             


Arg Ser  Val Trp Lys Asp Leu  Leu Glu Asp Thr Glu  Thr Pro Ile 
    2540                 2545                 2550             


Asp Thr  Thr Ile Met Ala Lys  Asn Glu Val Phe Cys  Val Gln Pro 
    2555                 2560                 2565             


Glu Lys  Gly Gly Arg Lys Pro  Ala Arg Leu Ile Val  Phe Pro Asp 
    2570                 2575                 2580             


Leu Gly  Val Arg Val Cys Glu  Lys Met Ala Leu Tyr  Asp Val Val 
    2585                 2590                 2595             


Ser Thr  Leu Pro Gln Ala Val  Met Gly Ser Ser Tyr  Gly Phe Gln 
    2600                 2605                 2610             


Tyr Ser  Pro Gly Gln Arg Val  Glu Phe Leu Val Asn  Ala Trp Lys 
    2615                 2620                 2625             


Ala Lys  Lys Cys Pro Met Gly  Phe Ala Tyr Asp Thr  Arg Cys Phe 
    2630                 2635                 2640             


Asp Ser  Thr Val Thr Glu Asn  Asp Ile Arg Val Glu  Glu Ser Ile 
    2645                 2650                 2655             


Tyr Gln  Cys Cys Asp Leu Ala  Pro Glu Ala Arg Gln  Ala Ile Arg 
    2660                 2665                 2670             


Ser Leu  Thr Glu Arg Leu Tyr  Ile Gly Gly Pro Leu  Thr Asn Ser 
    2675                 2680                 2685             


Lys Gly  Gln Asn Cys Gly Tyr  Arg Arg Cys Arg Ala  Ser Gly Val 
    2690                 2695                 2700             


Leu Thr  Thr Ser Cys Gly Asn  Thr Leu Thr Cys Tyr  Leu Lys Ala 
    2705                 2710                 2715             


Ala Ala  Ala Cys Arg Ala Ala  Lys Leu Gln Asp Cys  Thr Met Leu 
    2720                 2725                 2730             


Val Cys  Gly Asp Asp Leu Val  Val Ile Cys Glu Ser  Ala Gly Thr 
    2735                 2740                 2745             


Gln Glu  Asp Glu Ala Ser Leu  Arg Ala Phe Thr Glu  Ala Met Thr 
    2750                 2755                 2760             


Arg Tyr  Ser Ala Pro Pro Gly  Asp Pro Pro Lys Pro  Glu Tyr Asp 
    2765                 2770                 2775             


Leu Glu  Leu Ile Thr Ser Cys  Ser Ser Asn Val Ser  Val Ala His 
    2780                 2785                 2790             


Asp Ala  Ser Gly Lys Arg Val  Tyr Tyr Leu Thr Arg  Asp Pro Thr 
    2795                 2800                 2805             


Thr Pro  Leu Ala Arg Ala Ala  Trp Glu Thr Ala Arg  His Thr Pro 
    2810                 2815                 2820             


Val Asn  Ser Trp Leu Gly Asn  Ile Ile Met Tyr Ala  Pro Thr Leu 
    2825                 2830                 2835             


Trp Ala  Arg Met Ile Leu Met  Thr His Phe Phe Ser  Ile Leu Leu 
    2840                 2845                 2850             


Ala Gln  Glu Gln Leu Glu Lys  Ala Leu Asp Cys Gln  Ile Tyr Gly 
    2855                 2860                 2865             


Ala Cys  Tyr Ser Ile Glu Pro  Leu Asp Leu Pro Gln  Ile Ile Gln 
    2870                 2875                 2880             


Arg Leu  His Gly Leu Ser Ala  Phe Ser Leu His Ser  Tyr Ser Pro 
    2885                 2890                 2895             


Gly Glu  Ile Asn Arg Val Ala  Ser Cys Leu Arg Lys  Leu Gly Val 
    2900                 2905                 2910             


Pro Pro  Leu Arg Val Trp Arg  His Arg Ala Arg Ser  Val Arg Ala 
    2915                 2920                 2925             


Arg Leu  Leu Ser Gln Gly Gly  Arg Ala Ala Thr Cys  Gly Lys Tyr 
    2930                 2935                 2940             


Leu Phe  Asn Trp Ala Val Arg  Thr Lys Leu Lys Leu  Thr Pro Ile 
    2945                 2950                 2955             


Pro Ala  Ala Ser Gln Leu Asp  Leu Ser Ser Trp Phe  Val Ala Gly 
    2960                 2965                 2970             


Tyr Ser  Gly Gly Asp Ile Tyr  His Ser Leu Ser Arg  Ala Arg Pro 
    2975                 2980                 2985             


Arg Trp  Phe Met Trp Cys Leu  Leu Leu Leu Ser Val  Gly Val Gly 
    2990                 2995                 3000             


Ile Tyr  Leu Leu Pro Asn Arg  
    3005                 3010 


<210>  3
<211>  447
<212>  PRT
<213>  Hepatitis C virus

<400>  3

Ser Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu Val Leu 
1               5                   10                  15      


Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Gln Leu Pro 
            20                  25                  30          


Gly Ile Pro Phe Val Ser Cys Gln Arg Gly Tyr Arg Gly Val Trp Arg 
        35                  40                  45              


Gly Asp Gly Ile Met His Thr Arg Cys His Cys Gly Ala Glu Ile Thr 
    50                  55                  60                  


Gly His Val Lys Asn Gly Thr Met Arg Ile Val Gly Pro Arg Thr Cys 
65                  70                  75                  80  


Arg Asn Met Trp Ser Gly Thr Phe Pro Ile Asn Ala Tyr Thr Thr Gly 
                85                  90                  95      


Pro Cys Thr Pro Leu Pro Ala Pro Asn Tyr Lys Phe Ala Leu Trp Arg 
            100                 105                 110         


Val Ser Ala Glu Glu Tyr Val Glu Ile Arg Arg Val Gly Asp Phe His 
        115                 120                 125             


Tyr Val Ser Gly Met Thr Thr Asp Asn Leu Lys Cys Pro Cys Gln Ile 
    130                 135                 140                 


Pro Ser Pro Glu Phe Phe Thr Glu Leu Asp Gly Val Arg Leu His Arg 
145                 150                 155                 160 


Phe Ala Pro Pro Cys Lys Pro Leu Leu Arg Glu Glu Val Ser Phe Arg 
                165                 170                 175     


Val Gly Leu His Glu Tyr Pro Val Gly Ser Gln Leu Pro Cys Glu Pro 
            180                 185                 190         


Glu Pro Asp Val Ala Val Leu Thr Ser Met Leu Thr Asp Pro Ser His 
        195                 200                 205             


Ile Thr Ala Glu Ala Ala Gly Arg Arg Leu Ala Arg Gly Ser Pro Pro 
    210                 215                 220                 


Ser Met Ala Ser Ser Ser Ala Ser Gln Leu Ser Ala Pro Ser Leu Lys 
225                 230                 235                 240 


Ala Thr Cys Thr Ala Asn His Asp Ser Pro Asp Ala Glu Leu Ile Glu 
                245                 250                 255     


Ala Asn Leu Leu Trp Arg Gln Glu Met Gly Gly Asn Ile Thr Arg Val 
            260                 265                 270         


Glu Ser Glu Asn Lys Val Val Ile Leu Asp Ser Phe Asp Pro Leu Val 
        275                 280                 285             


Ala Glu Glu Asp Glu Arg Glu Val Ser Val Pro Ala Glu Ile Leu Arg 
    290                 295                 300                 


Lys Ser Arg Arg Phe Ala Arg Ala Leu Pro Val Trp Ala Arg Pro Asp 
305                 310                 315                 320 


Tyr Asn Pro Pro Leu Val Glu Thr Trp Lys Lys Pro Asp Tyr Glu Pro 
                325                 330                 335     


Pro Val Val His Gly Cys Pro Leu Pro Pro Pro Arg Ser Pro Pro Val 
            340                 345                 350         


Pro Pro Pro Arg Lys Lys Arg Thr Val Val Leu Thr Glu Ser Thr Leu 
        355                 360                 365             


Ser Thr Ala Leu Ala Glu Leu Ala Thr Lys Ser Phe Gly Ser Ser Ser 
    370                 375                 380                 


Thr Ser Gly Ile Thr Gly Asp Asn Thr Thr Thr Ser Ser Glu Pro Ala 
385                 390                 395                 400 


Pro Ser Gly Cys Pro Pro Asp Ser Asp Val Glu Ser Tyr Ser Ser Met 
                405                 410                 415     


Pro Pro Leu Glu Gly Glu Pro Gly Asp Pro Asp Leu Ser Asp Gly Ser 
            420                 425                 430         


Trp Ser Thr Val Ser Ser Gly Ala Asp Thr Glu Asp Val Val Cys 
        435                 440                 445         


<210>  4
<211>  60
<212>  PRT
<213>  Hepatitis C virus

<400>  4

Arg Ala Leu Pro Val Trp Ala Arg Pro Asp Tyr Asn Pro Pro Leu Val 
1               5                   10                  15      


Glu Thr Trp Lys Lys Pro Asp Tyr Glu Pro Pro Val Val His Gly Cys 
            20                  25                  30          


Pro Leu Pro Pro Pro Arg Ser Pro Pro Val Pro Pro Pro Arg Lys Lys 
        35                  40                  45              


Arg Thr Val Val Leu Thr Glu Ser Thr Leu Ser Thr 
    50                  55                  60  


<210>  5
<211>  60
<212>  PRT
<213>  Hepatitis C virus

<400>  5

Arg Ala Met Pro Ile Trp Ala Arg Pro Asp Tyr Asn Pro Pro Leu Leu 
1               5                   10                  15      


Glu Ser Trp Lys Asp Pro Asp Tyr Val Pro Pro Val Val His Gly Cys 
            20                  25                  30          


Pro Leu Pro Pro Ala Lys Ala Pro Pro Ile Pro Pro Pro Arg Arg Lys 
        35                  40                  45              


Arg Thr Val Val Leu Ser Glu Ser Thr Val Ser Ser 
    50                  55                  60  


<210>  6
<211>  60
<212>  PRT
<213>  Hepatitis C virus

<400>  6

Arg Ala Leu Pro Val Trp Ala Arg Pro Asp Tyr Asn Pro Pro Leu Val 
1               5                   10                  15      


Glu Pro Trp Lys Lys Pro Asp Tyr Glu Pro Pro Val Val His Gly Cys 
            20                  25                  30          


Pro Leu Pro Pro Pro Gln Ser Pro Pro Val Pro Pro Pro Arg Lys Lys 
        35                  40                  45              


Arg Thr Val Val Leu Thr Glu Ser Thr Leu Pro Thr 
    50                  55                  60  


<210>  7
<211>  59
<212>  PRT
<213>  Hepatitis C virus

<400>  7

Arg Ala Leu Pro Ile Trp Ala Arg Pro Asp Tyr Asn Pro Pro Leu Val 
1               5                   10                  15      


Glu Ser Trp Lys Lys Pro Asp Tyr Glu Pro Pro Val Val His Gly Cys 
            20                  25                  30          


Pro Leu Pro Pro Pro Arg Ser Pro Pro Val Pro Pro Pro Arg Lys Lys 
        35                  40                  45              


Arg Thr Val Val Leu Thr Glu Ser Thr Leu Pro 
    50                  55                  


<210>  8
<211>  13
<212>  PRT
<213>  Hepatitis C virus

<400>  8

Trp Ala Arg Pro Asp Tyr Asn Pro Pro Leu Val Glu Pro 
1               5                   10              


<210>  9
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  9
gtaaaacgac ggccagtccg ctccatctct caaggc                                 36


<210>  10
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  10
caggaaacag ctatgactgc ctttggcaag cactgcg                                37


<210>  11
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  11
gtaaaacgac ggccagaacc acctgtggtc catgg                                  35


<210>  12
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  12
caggaaacag ctatgactta cgacccccct tctcrgg                                37


<210>  13
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  13
gtaaaacgac ggccagggar gaygtcgtgt gctgc                                  35


<210>  14
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  14
caggaaacag ctatgacatt gcctcctccg tacgg                                  35


<210>  15
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  15
ttcgctcgag ccctgcccgt ttgggcgcgg ccggactaca accccccgct agtagagccc       60

tggaaaaag                                                               69


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  16
ccatgtatac gacattgagc agcag                                             25


