                         SEQUENCE LISTING

<110>  Hansson, Gran K.
 
<120>  IMMUNOMODULATORY METHODS AND SYSTEMS FOR TREATMENT AND/OR 
       PREVENTION OF ATHEROSCLEROSIS AND RELATED PROTEINS, PEPTIDES AND 
       COMPOSITIONS

<130>  PC1076EC

<150>  61/385, 548
<151>  2010-09-22

<150>  PCT/SE2010/050299
<151>  2010-03-17

<150>  SE0950161-0
<151>  2009-03-17

<150>  13/257,045
<151>  2011-09-16

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  1

Ala Thr Gly Gly Thr Leu Gln Gln Leu Phe Tyr Ser Ile Thr Val Gly 
1               5                   10                  15      


Gln Val 
        


<210>  2
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
tggatggttt gaaggacagt g                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
ctgtttatct ctgctgaccg g                                                 21


<210>  4
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
acgaaggaca aggattcact gt                                                22


<210>  5
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
ctggaggact caggcactta ct                                                22


<210>  6
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
ggtacccgac tcttttctgg t                                                 21


<210>  7
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
accctttcag aagatgactt cc                                                22


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
tttaaagtcc caaaggccaa                                                   20


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
tcctgaaagt cattacggct g                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
agagcctcaa gggacaaaga g                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
agactcccag cccagtgact                                                   20


<210>  12
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
acatcagaga gccgcaacc                                                    19


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
ccctgcccag ctaatcttaa t                                                 21


<210>  14
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
ctgcagctga gatgcaagta tt                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
tcctatggtg gatccattta cc                                                22


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
tggacagaaa acagagccaa                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
caggcaaagg tcttgtgtcc                                                   20


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
acgccactct ccataagagc a                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
gctctttgca catttcctcc                                                   20


<210>  20
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
tgcagttatg aggacagcac tt                                                22


<210>  21
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
ctgcagttat gagaacagtg ctt                                               23


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
ccagacgatt cgggaaagta                                                   20


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
ttccatcgga ctcatcatca c                                                 21


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
aacctgaaga aatccccagc                                                   20


<210>  25
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
ggaagacgga agattcacag tt                                                22


<210>  26
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
acgctcctaa tagacattcg ct                                                22


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
gttcctcttc agggtccaga                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
caccagcagg ttctgggttc                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
acacgggtca ctgatacgga                                                   20


<210>  30
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
atggacaatc agactgcctc a                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
tcactctgaa aatccaaccc a                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
taaacgaaac agttccaagg c                                                 21


<210>  33
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
acggtgccca gtcgttttat                                                   20


<210>  34
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
ggattcctac ccagcagatt c                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
agataaagga aacctgccca g                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
ccagaacaac gcaagaagac t                                                 21


<210>  37
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  37
ggctaccccc tctcagacat                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
tggcttccct ttctcagaca                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
gcgacacagc cacctatctc                                                   20


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
cgcagcaagt ctcttatgga a                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
atagatgatt cagggatgcc c                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
tgagaagttc caatccagtc g                                                 21


<210>  43
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
gaaggctatg atgcgtctcg                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
ttcccatcag tcatcccaac                                                   20


<210>  45
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
aaaatgccct gctaagaaac c                                                 21


<210>  46
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
cagcctggga atcagaacg                                                    19


<210>  47
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
gcatcctgga aatcctatcc t                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
agtgtccttc aaactcacct t                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
aaaggataca gggtctcacg g                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  50
ggacaagttt ccaatcagcc g                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  51
ttcatcctaa gcacggagaa g                                                 21


<210>  52
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  52
tgcaatctct gcttttgatg gctc                                              24


<210>  53
<211>  906
<212>  DNA
<213>  mouse


<220>
<221>  CDS
<222>  (1)..(906)
<223>  Sequence coding for V beta 31 from hybridomas 45

<400>  53
atg ctg tac tct ctc ctt gcc ttt ctc ctg ggc atg ttc ttg ggt gtt         48
Met Leu Tyr Ser Leu Leu Ala Phe Leu Leu Gly Met Phe Leu Gly Val           
1               5                   10                  15                

agt gct cag act atc cat caa tgg cca gtt gcc gag atc aag gct gtg         96
Ser Ala Gln Thr Ile His Gln Trp Pro Val Ala Glu Ile Lys Ala Val           
            20                  25                  30                    

ggc agc cca ctg tct ctg ggg tgt acc ata aag ggg aaa tca agc cct        144
Gly Ser Pro Leu Ser Leu Gly Cys Thr Ile Lys Gly Lys Ser Ser Pro           
        35                  40                  45                        

aac ctc tac tgg tac tgg cag gcc aca gga ggc acc ctc cag caa ctc        192
Asn Leu Tyr Trp Tyr Trp Gln Ala Thr Gly Gly Thr Leu Gln Gln Leu           
    50                  55                  60                            

ttc tac tct att act gtt ggc cag gta gag tcg gtg gtg caa ctg aac        240
Phe Tyr Ser Ile Thr Val Gly Gln Val Glu Ser Val Val Gln Leu Asn           
65                  70                  75                  80            

ctc tca gct tcc agg ccg aag gac gac caa ttc atc cta agc acg gag        288
Leu Ser Ala Ser Arg Pro Lys Asp Asp Gln Phe Ile Leu Ser Thr Glu           
                85                  90                  95                

aag ctg ctt ctc agc cac tct ggc ttc tac ctc tgt gcc tgg agt cta        336
Lys Leu Leu Leu Ser His Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu           
            100                 105                 110                   

ggc agc cag aga gtc ttc ttt ggt aaa gga acc aga ctc aca gtt gta        384
Gly Ser Gln Arg Val Phe Phe Gly Lys Gly Thr Arg Leu Thr Val Val           
        115                 120                 125                       

gag gat ctg aga aat gtg act cca ccc aag gtc tcc ttg ttt gag cca        432
Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro           
    130                 135                 140                           

tca aaa gca gag att gca aac aaa caa aag gct acc ctc gtg tgc ttg        480
Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu           
145                 150                 155                 160           

gcc agg ggc ttc ttc cct gac cac gtg gag ctg agc tgg tgg gtg aat        528
Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn           
                165                 170                 175               

ggc aag gag gtc cac agt ggg gtc agc acg gac cct cag gcc tac aag        576
Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys           
            180                 185                 190                   

gag agc aat tat agc tac tgc ctg agc agc cgc ctg agg gtc tct gct        624
Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala           
        195                 200                 205                       

acc ttc tgg cac aat cct cgc aac cac ttc cgc tgc caa gtg cag ttc        672
Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe           
    210                 215                 220                           

cat ggg ctt tca gag gag gac aag tgg cca gag ggc tca ccc aaa cct        720
His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro           
225                 230                 235                 240           

gtc aca cag aac atc agt gca gag gcc tgg ggc cga gca gac tgt ggg        768
Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly           
                245                 250                 255               

att acc tca gca tcc tat caa caa ggg gtc ttg tct gcc acc atc ctc        816
Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu           
            260                 265                 270                   

tat gag atc ctg cta ggg aaa gcc acc ctg tat gct gtg ctt gtc agt        864
Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser           
        275                 280                 285                       

aca ctg gtg gtg atg gct atg gtc aaa aga aag aat tca tga                906
Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser                       
    290                 295                 300                           


<210>  54
<211>  301
<212>  PRT
<213>  mouse

<400>  54

Met Leu Tyr Ser Leu Leu Ala Phe Leu Leu Gly Met Phe Leu Gly Val 
1               5                   10                  15      


Ser Ala Gln Thr Ile His Gln Trp Pro Val Ala Glu Ile Lys Ala Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Gly Cys Thr Ile Lys Gly Lys Ser Ser Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Trp Gln Ala Thr Gly Gly Thr Leu Gln Gln Leu 
    50                  55                  60                  


Phe Tyr Ser Ile Thr Val Gly Gln Val Glu Ser Val Val Gln Leu Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Lys Asp Asp Gln Phe Ile Leu Ser Thr Glu 
                85                  90                  95      


Lys Leu Leu Leu Ser His Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu 
            100                 105                 110         


Gly Ser Gln Arg Val Phe Phe Gly Lys Gly Thr Arg Leu Thr Val Val 
        115                 120                 125             


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
    130                 135                 140                 


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
                165                 170                 175     


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
            180                 185                 190         


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
        195                 200                 205             


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
    210                 215                 220                 


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
225                 230                 235                 240 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
                245                 250                 255     


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
            260                 265                 270         


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
        275                 280                 285             


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300     


<210>  55
<211>  301
<212>  PRT
<213>  mouse

<400>  55

Met Leu Tyr Ser Leu Leu Ala Phe Leu Leu Gly Met Phe Leu Gly Val 
1               5                   10                  15      


Ser Ala Gln Thr Ile His Gln Trp Pro Val Ala Glu Ile Lys Ala Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Gly Cys Thr Ile Lys Gly Lys Ser Ser Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Trp Gln Ala Thr Gly Gly Thr Leu Gln Gln Leu 
    50                  55                  60                  


Phe Tyr Ser Ile Thr Val Gly Gln Val Glu Ser Val Val Gln Leu Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Lys Asp Asp Gln Phe Ile Leu Ser Thr Glu 
                85                  90                  95      


Lys Leu Leu Leu Ser His Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu 
            100                 105                 110         


Gly Ser Gln Arg Val Phe Phe Gly Lys Gly Thr Arg Leu Thr Val Val 
        115                 120                 125             


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
    130                 135                 140                 


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
                165                 170                 175     


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
            180                 185                 190         


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
        195                 200                 205             


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
    210                 215                 220                 


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
225                 230                 235                 240 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
                245                 250                 255     


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
            260                 265                 270         


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
        275                 280                 285             


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300     


<210>  56
<211>  918
<212>  DNA
<213>  mouse


<220>
<221>  CDS
<222>  (1)..(918)
<223>  Sequence coding for V beta 31from hybridomas 15

<400>  56
atg ctg tac tct ctc ctt gcc ttt ctc ctg ggc atg ttc ttg ggt gtt         48
Met Leu Tyr Ser Leu Leu Ala Phe Leu Leu Gly Met Phe Leu Gly Val           
1               5                   10                  15                

agt gct cag act atc cat caa tgg cca gtt gcc gag atc aag gct gtg         96
Ser Ala Gln Thr Ile His Gln Trp Pro Val Ala Glu Ile Lys Ala Val           
            20                  25                  30                    

ggc agc cca ctg tct ctg ggg tgt acc ata aag ggg aaa tca agc cct        144
Gly Ser Pro Leu Ser Leu Gly Cys Thr Ile Lys Gly Lys Ser Ser Pro           
        35                  40                  45                        

aac ctc tac tgg tac tgg cag gcc aca gga ggc acc ctc cag caa ctc        192
Asn Leu Tyr Trp Tyr Trp Gln Ala Thr Gly Gly Thr Leu Gln Gln Leu           
    50                  55                  60                            

ttc tac tct att act gtt ggc cag gta gag tcg gtg gtg caa ctg aac        240
Phe Tyr Ser Ile Thr Val Gly Gln Val Glu Ser Val Val Gln Leu Asn           
65                  70                  75                  80            

ctc tca gct tcc agg ccg aag gac gac caa ttc atc cta agc acg gag        288
Leu Ser Ala Ser Arg Pro Lys Asp Asp Gln Phe Ile Leu Ser Thr Glu           
                85                  90                  95                

aag ctg ctt ctc agc cac tct ggc ttc tac ctc tgt gcc tgg agt cta        336
Lys Leu Leu Leu Ser His Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu           
            100                 105                 110                   

act ggg ggg aat agt caa aac acc ttg tac ttt ggt gcg ggc acc cga        384
Thr Gly Gly Asn Ser Gln Asn Thr Leu Tyr Phe Gly Ala Gly Thr Arg           
        115                 120                 125                       

cta tcg gtg cta gag gat ctg aga aat gtg act cca ccc aag gtc tcc        432
Leu Ser Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser           
    130                 135                 140                           

ttg ttt gag cca tca aaa gca gag att gca aac aaa caa aag gct acc        480
Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr           
145                 150                 155                 160           

ctc gtg tgc ttg gcc agg ggc ttc ttc cct gac cac gtg gag ctg agc        528
Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser           
                165                 170                 175               

tgg tgg gtg aat ggc aag gag gtc cac agt ggg gtc agc acg gac cct        576
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro           
            180                 185                 190                   

cag gcc tac aag gag agc aat tat agc tac tgc ctg agc agc cgc ctg        624
Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu           
        195                 200                 205                       

agg gtc tct gct acc ttc tgg cac aat cct cga aac cac ttc cgc tgc        672
Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys           
    210                 215                 220                           

caa gtg cag ttc cat ggg ctt tca gag gag gac aag tgg cca gag ggc        720
Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly           
225                 230                 235                 240           

tca ccc aaa cct gtc aca cag aac atc agt gca gag gcc tgg ggc cga        768
Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg           
                245                 250                 255               

gca gac tgt gga atc act tca gca tcc tat cat cag ggg gtt ctg tct        816
Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser           
            260                 265                 270                   

gca acc atc ctc tat gag atc cta ctg ggg aag gcc acc cta tat gct        864
Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala           
        275                 280                 285                       

gtg ctg gtc agt ggc ctg gtg ctg atg gcc atg gtc aag aga aaa aat        912
Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Arg Lys Asn           
    290                 295                 300                           

tcc tga                                                                918
Ser                                                                       
305                                                                       


<210>  57
<211>  305
<212>  PRT
<213>  mouse

<400>  57

Met Leu Tyr Ser Leu Leu Ala Phe Leu Leu Gly Met Phe Leu Gly Val 
1               5                   10                  15      


Ser Ala Gln Thr Ile His Gln Trp Pro Val Ala Glu Ile Lys Ala Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Gly Cys Thr Ile Lys Gly Lys Ser Ser Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Trp Gln Ala Thr Gly Gly Thr Leu Gln Gln Leu 
    50                  55                  60                  


Phe Tyr Ser Ile Thr Val Gly Gln Val Glu Ser Val Val Gln Leu Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Lys Asp Asp Gln Phe Ile Leu Ser Thr Glu 
                85                  90                  95      


Lys Leu Leu Leu Ser His Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu 
            100                 105                 110         


Thr Gly Gly Asn Ser Gln Asn Thr Leu Tyr Phe Gly Ala Gly Thr Arg 
        115                 120                 125             


Leu Ser Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  58
<211>  305
<212>  PRT
<213>  mouse

<400>  58

Met Leu Tyr Ser Leu Leu Ala Phe Leu Leu Gly Met Phe Leu Gly Val 
1               5                   10                  15      


Ser Ala Gln Thr Ile His Gln Trp Pro Val Ala Glu Ile Lys Ala Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Gly Cys Thr Ile Lys Gly Lys Ser Ser Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Trp Gln Ala Thr Gly Gly Thr Leu Gln Gln Leu 
    50                  55                  60                  


Phe Tyr Ser Ile Thr Val Gly Gln Val Glu Ser Val Val Gln Leu Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Lys Asp Asp Gln Phe Ile Leu Ser Thr Glu 
                85                  90                  95      


Lys Leu Leu Leu Ser His Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu 
            100                 105                 110         


Thr Gly Gly Asn Ser Gln Asn Thr Leu Tyr Phe Gly Ala Gly Thr Arg 
        115                 120                 125             


Leu Ser Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  59
<211>  903
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  CDS
<222>  (1)..(903)
<223>  Sequence coding for V beta 31 from hybridomas 48

<400>  59
atg ctg tac tct ctc ctt gcc ttt ctc ctg ggc atg ttc ttg ggt gtt         48
Met Leu Tyr Ser Leu Leu Ala Phe Leu Leu Gly Met Phe Leu Gly Val           
1               5                   10                  15                

agt gct cag act atc cat caa tgg cca gtt gcc gag atc aag gct gtg         96
Ser Ala Gln Thr Ile His Gln Trp Pro Val Ala Glu Ile Lys Ala Val           
            20                  25                  30                    

ggc agc cca ctg tct ctg ggg tgt acc ata aag ggg aaa tca agc cct        144
Gly Ser Pro Leu Ser Leu Gly Cys Thr Ile Lys Gly Lys Ser Ser Pro           
        35                  40                  45                        

aac ctc tac tgg tac tgg cag gcc aca gga ggc acc ctc cag caa ctc        192
Asn Leu Tyr Trp Tyr Trp Gln Ala Thr Gly Gly Thr Leu Gln Gln Leu           
    50                  55                  60                            

ttc tac tct att act gtt ggc cag gta gag tcg gtg gtg caa ctg aac        240
Phe Tyr Ser Ile Thr Val Gly Gln Val Glu Ser Val Val Gln Leu Asn           
65                  70                  75                  80            

ctc tca gct tcc agg ccg aag gac gac caa ttc atc cta agc acg gag        288
Leu Ser Ala Ser Arg Pro Lys Asp Asp Gln Phe Ile Leu Ser Thr Glu           
                85                  90                  95                

aag ctg ctt ctc agc cac tct ggc ttc tac ctc tgt gcc tgg agt cta        336
Lys Leu Leu Leu Ser His Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu           
            100                 105                 110                   

gaa ggt gaa cag tac ttc ggt ccc ggc acc agg ctc acg gtt tta gag        384
Glu Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu           
        115                 120                 125                       

gat ctg aga aat gtg act cca ccc aag gtc tcc ttg ttt gag cca tca        432
Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser           
    130                 135                 140                           

aaa gca gag att gca aac aaa caa aag gct acc ctc gtg tgc ttg gcc        480
Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala           
145                 150                 155                 160           

agg ggc ttc ttc cct gac cac gtg gag ctg agc tgg tgg gtg aat ggc        528
Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly           
                165                 170                 175               

aag gag gtc cac agt ggg gtc agc acg gac cct cag gcc tac aag gag        576
Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu           
            180                 185                 190                   

agc aat tat agc tac tgc ctg agc agc cgc ctg agg gtc tct gct acc        624
Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr           
        195                 200                 205                       

ttc tgg cac aat cct cga aac cac ttc cgc tgc caa gtg cag ttc cat        672
Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His           
    210                 215                 220                           

ggg ctt tca gag gag gac aag tgg cca gag ggc tca ccc aaa cct gtc        720
Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val           
225                 230                 235                 240           

aca cag aac atc agt gca gag gcc tgg ggc cga gca gac tgt gga atc        768
Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile           
                245                 250                 255               

act tca gca tcc tat cat cag ggg gtt ctg tct gca acc atc ctc tat        816
Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr           
            260                 265                 270                   

gag atc cta ctg ggg aag gcc acc cta tat gct gtg ctg gtc agt ggc        864
Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Gly           
        275                 280                 285                       

ctg gtg ctg atg gcc atg gtc aag aaa aaa aat tcc tga                    903
Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser                           
    290                 295                 300                           


<210>  60
<211>  300
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  60

Met Leu Tyr Ser Leu Leu Ala Phe Leu Leu Gly Met Phe Leu Gly Val 
1               5                   10                  15      


Ser Ala Gln Thr Ile His Gln Trp Pro Val Ala Glu Ile Lys Ala Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Gly Cys Thr Ile Lys Gly Lys Ser Ser Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Trp Gln Ala Thr Gly Gly Thr Leu Gln Gln Leu 
    50                  55                  60                  


Phe Tyr Ser Ile Thr Val Gly Gln Val Glu Ser Val Val Gln Leu Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Lys Asp Asp Gln Phe Ile Leu Ser Thr Glu 
                85                  90                  95      


Lys Leu Leu Leu Ser His Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu 
            100                 105                 110         


Glu Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu 
        115                 120                 125             


Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
    130                 135                 140                 


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
145                 150                 155                 160 


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
                165                 170                 175     


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu 
            180                 185                 190         


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
        195                 200                 205             


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
    210                 215                 220                 


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
225                 230                 235                 240 


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
                245                 250                 255     


Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
            260                 265                 270         


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Gly 
        275                 280                 285             


Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300 


<210>  61
<211>  825
<212>  DNA
<213>  mouse


<220>
<221>  CDS
<222>  (1)..(825)
<223>  Sequence coding for V alpha 14 from hybridomas 15

<400>  61
atg gac aag atc ctg aca gca tcg ttt tta ctc cta ggc ctt cac cta         48
Met Asp Lys Ile Leu Thr Ala Ser Phe Leu Leu Leu Gly Leu His Leu           
1               5                   10                  15                

gct ggg gtg aat ggc cag cag aag gag aaa cat gac cag cag cag gtg         96
Ala Gly Val Asn Gly Gln Gln Lys Glu Lys His Asp Gln Gln Gln Val           
            20                  25                  30                    

aga caa agt ccc caa tct ctg aca gtc tgg gaa gga gga acc aca gtt        144
Arg Gln Ser Pro Gln Ser Leu Thr Val Trp Glu Gly Gly Thr Thr Val           
        35                  40                  45                        

ctg acc tgc agt tat gag gac agc act ttt aac tac ttc cca tgg tac        192
Leu Thr Cys Ser Tyr Glu Asp Ser Thr Phe Asn Tyr Phe Pro Trp Tyr           
    50                  55                  60                            

caa cag ttc cct ggg gaa ggc cct gca ctt ctg ata tcc ata ctt tca        240
Gln Gln Phe Pro Gly Glu Gly Pro Ala Leu Leu Ile Ser Ile Leu Ser           
65                  70                  75                  80            

gtg tcc gat aaa aag gaa gat gga cga ttc aca acc ttc ttc aat aaa        288
Val Ser Asp Lys Lys Glu Asp Gly Arg Phe Thr Thr Phe Phe Asn Lys           
                85                  90                  95                

agg gag aaa aag ctc tcc ttg cac atc ata gac tct cag cct gga gac        336
Arg Glu Lys Lys Leu Ser Leu His Ile Ile Asp Ser Gln Pro Gly Asp           
            100                 105                 110                   

tca gcc acc tac ttc tgt gca gca agt gtg ggt gcc aag ctc aca ttc        384
Ser Ala Thr Tyr Phe Cys Ala Ala Ser Val Gly Ala Lys Leu Thr Phe           
        115                 120                 125                       

gga ggg gga aca agg tta acg gtc aga ccc gac atc cag aac cca gaa        432
Gly Gly Gly Thr Arg Leu Thr Val Arg Pro Asp Ile Gln Asn Pro Glu           
    130                 135                 140                           

cct gct gtg tac cag tta aaa gat cct cgg tct cag gac agc acc ctc        480
Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu           
145                 150                 155                 160           

tgc ctg ttc acc gac ttt gac tcc caa atc aat gtg ccg aaa acc atg        528
Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met           
                165                 170                 175               

gaa tct gga acg ttc atc act gac aaa act gtg ctg gac atg aaa gct        576
Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala           
            180                 185                 190                   

atg gat tcc aag agc aat ggg gcc att gcc tgg agc aac cag aca agc        624
Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser           
        195                 200                 205                       

ttc acc tgc caa gat atc ttc aaa gag acc aac gcc acc tac ccc agt        672
Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser           
    210                 215                 220                           

tca gac gtt ccc tgt gat gcc acg ttg act gag aaa agc ttt gaa aca        720
Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr           
225                 230                 235                 240           

gat atg aac cta aac ttt caa aac ctg tca gtt atg gga ctc cga atc        768
Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile           
                245                 250                 255               

ctc ctg ctg aaa gta gcc gga ttt aac ctg ctc atg acg ctg agg ctg        816
Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu           
            260                 265                 270                   

tgg tcc tga                                                            825
Trp Ser                                                                   
                                                                          


<210>  62
<211>  274
<212>  PRT
<213>  mouse

<400>  62

Met Asp Lys Ile Leu Thr Ala Ser Phe Leu Leu Leu Gly Leu His Leu 
1               5                   10                  15      


Ala Gly Val Asn Gly Gln Gln Lys Glu Lys His Asp Gln Gln Gln Val 
            20                  25                  30          


Arg Gln Ser Pro Gln Ser Leu Thr Val Trp Glu Gly Gly Thr Thr Val 
        35                  40                  45              


Leu Thr Cys Ser Tyr Glu Asp Ser Thr Phe Asn Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Glu Gly Pro Ala Leu Leu Ile Ser Ile Leu Ser 
65                  70                  75                  80  


Val Ser Asp Lys Lys Glu Asp Gly Arg Phe Thr Thr Phe Phe Asn Lys 
                85                  90                  95      


Arg Glu Lys Lys Leu Ser Leu His Ile Ile Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Ser Val Gly Ala Lys Leu Thr Phe 
        115                 120                 125             


Gly Gly Gly Thr Arg Leu Thr Val Arg Pro Asp Ile Gln Asn Pro Glu 
    130                 135                 140                 


Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu 
145                 150                 155                 160 


Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met 
                165                 170                 175     


Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala 
            180                 185                 190         


Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser 
        195                 200                 205             


Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser 
    210                 215                 220                 


Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser 
        


<210>  63
<211>  274
<212>  PRT
<213>  mouse

<400>  63

Met Asp Lys Ile Leu Thr Ala Ser Phe Leu Leu Leu Gly Leu His Leu 
1               5                   10                  15      


Ala Gly Val Asn Gly Gln Gln Lys Glu Lys His Asp Gln Gln Gln Val 
            20                  25                  30          


Arg Gln Ser Pro Gln Ser Leu Thr Val Trp Glu Gly Gly Thr Thr Val 
        35                  40                  45              


Leu Thr Cys Ser Tyr Glu Asp Ser Thr Phe Asn Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Glu Gly Pro Ala Leu Leu Ile Ser Ile Leu Ser 
65                  70                  75                  80  


Val Ser Asp Lys Lys Glu Asp Gly Arg Phe Thr Thr Phe Phe Asn Lys 
                85                  90                  95      


Arg Glu Lys Lys Leu Ser Leu His Ile Ile Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Ser Val Gly Ala Lys Leu Thr Phe 
        115                 120                 125             


Gly Gly Gly Thr Arg Leu Thr Val Arg Pro Asp Ile Gln Asn Pro Glu 
    130                 135                 140                 


Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu 
145                 150                 155                 160 


Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met 
                165                 170                 175     


Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala 
            180                 185                 190         


Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser 
        195                 200                 205             


Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser 
    210                 215                 220                 


Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser 
        


<210>  64
<211>  807
<212>  DNA
<213>  mouse


<220>
<221>  CDS
<222>  (1)..(807)
<223>  Sequence coding for V alpha 12 from hybridomas 48

<400>  64
atg cgt cct gtc acc tcc tca gtt ctc gtg ctc ctc cta atg ctc aga         48
Met Arg Pro Val Thr Ser Ser Val Leu Val Leu Leu Leu Met Leu Arg           
1               5                   10                  15                

agg agc aat gga gac tca gtg acc cag aca gaa ggc ctg gtc act ctc         96
Arg Ser Asn Gly Asp Ser Val Thr Gln Thr Glu Gly Leu Val Thr Leu           
            20                  25                  30                    

acc gag ggg ttg cct gtg atg ctg aac tgc acc tat cag act gct tac        144
Thr Glu Gly Leu Pro Val Met Leu Asn Cys Thr Tyr Gln Thr Ala Tyr           
        35                  40                  45                        

tca act ttc ctt ttc tgg tat gtg caa cat ctc aat gaa gcc cct aaa        192
Ser Thr Phe Leu Phe Trp Tyr Val Gln His Leu Asn Glu Ala Pro Lys           
    50                  55                  60                            

cta ctc ctg aag agc tcc aca gac aac aag agg acc gag cac caa ggg        240
Leu Leu Leu Lys Ser Ser Thr Asp Asn Lys Arg Thr Glu His Gln Gly           
65                  70                  75                  80            

ttc cac gcc act ctc cat aag agc agc agc tcc ttc cat ctg cag aag        288
Phe His Ala Thr Leu His Lys Ser Ser Ser Ser Phe His Leu Gln Lys           
                85                  90                  95                

tcc tca gcg cag ctg tca gac tct gcc ctg tac tac tgt gct ctg agt        336
Ser Ser Ala Gln Leu Ser Asp Ser Ala Leu Tyr Tyr Cys Ala Leu Ser           
            100                 105                 110                   

gat caa gga ggg tct gcg aag ctc atc ttt ggg gag ggg aca aag ctg        384
Asp Gln Gly Gly Ser Ala Lys Leu Ile Phe Gly Glu Gly Thr Lys Leu           
        115                 120                 125                       

aca gtg agc tca tac atc cag aac cca gaa cct gct gtg tac cag tta        432
Thr Val Ser Ser Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu           
    130                 135                 140                           

aaa gat cct cgg tct cag gac agc acc ctc tgc ctg ttc acc gac ttt        480
Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe           
145                 150                 155                 160           

gac tcc caa atc aat gtg ccg aaa acc atg gaa tct gga acg ttc atc        528
Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile           
                165                 170                 175               

act gac aaa act gtg ctg gac atg aaa gct atg gat tcc aag agc aat        576
Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn           
            180                 185                 190                   

ggg gcc att gcc tgg agc aac cag aca agc ttc acc tgc caa gat atc        624
Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile           
        195                 200                 205                       

ttc aaa gag acc aac gcc acc tac ccc agt tca gac gtt ccc tgt gat        672
Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp           
    210                 215                 220                           

gcc acg ttg acc gag aaa agc ttt gaa aca gat atg aac cta aac ttt        720
Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe           
225                 230                 235                 240           

caa aac ctg tca gtt atg gga ctc cga atc ctc ctg ctg aaa gta gcg        768
Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala           
                245                 250                 255               

gga ttt aac ctg ctc atg acg ctg agg ctg tgg tcc tga                    807
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser                           
            260                 265                                       


<210>  65
<211>  268
<212>  PRT
<213>  mouse

<400>  65

Met Arg Pro Val Thr Ser Ser Val Leu Val Leu Leu Leu Met Leu Arg 
1               5                   10                  15      


Arg Ser Asn Gly Asp Ser Val Thr Gln Thr Glu Gly Leu Val Thr Leu 
            20                  25                  30          


Thr Glu Gly Leu Pro Val Met Leu Asn Cys Thr Tyr Gln Thr Ala Tyr 
        35                  40                  45              


Ser Thr Phe Leu Phe Trp Tyr Val Gln His Leu Asn Glu Ala Pro Lys 
    50                  55                  60                  


Leu Leu Leu Lys Ser Ser Thr Asp Asn Lys Arg Thr Glu His Gln Gly 
65                  70                  75                  80  


Phe His Ala Thr Leu His Lys Ser Ser Ser Ser Phe His Leu Gln Lys 
                85                  90                  95      


Ser Ser Ala Gln Leu Ser Asp Ser Ala Leu Tyr Tyr Cys Ala Leu Ser 
            100                 105                 110         


Asp Gln Gly Gly Ser Ala Lys Leu Ile Phe Gly Glu Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Ser Ser Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265             


<210>  66
<211>  268
<212>  PRT
<213>  mouse

<400>  66

Met Arg Pro Val Thr Ser Ser Val Leu Val Leu Leu Leu Met Leu Arg 
1               5                   10                  15      


Arg Ser Asn Gly Asp Ser Val Thr Gln Thr Glu Gly Leu Val Thr Leu 
            20                  25                  30          


Thr Glu Gly Leu Pro Val Met Leu Asn Cys Thr Tyr Gln Thr Ala Tyr 
        35                  40                  45              


Ser Thr Phe Leu Phe Trp Tyr Val Gln His Leu Asn Glu Ala Pro Lys 
    50                  55                  60                  


Leu Leu Leu Lys Ser Ser Thr Asp Asn Lys Arg Thr Glu His Gln Gly 
65                  70                  75                  80  


Phe His Ala Thr Leu His Lys Ser Ser Ser Ser Phe His Leu Gln Lys 
                85                  90                  95      


Ser Ser Ala Gln Leu Ser Asp Ser Ala Leu Tyr Tyr Cys Ala Leu Ser 
            100                 105                 110         


Asp Gln Gly Gly Ser Ala Lys Leu Ile Phe Gly Glu Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Ser Ser Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265             


<210>  67
<211>  804
<212>  DNA
<213>  mouse


<220>
<221>  CDS
<222>  (1)..(804)
<223>  Sequence coding for V alpha 4 from hybridomas 45

<400>  67
atg cag agg aac ctg gga gct gtg ctg ggg att ctg tgg gtg cag att         48
Met Gln Arg Asn Leu Gly Ala Val Leu Gly Ile Leu Trp Val Gln Ile           
1               5                   10                  15                

tgc tgg gtg aga gga gat cag gtg gag cag agt cct tca gcc ctg agc         96
Cys Trp Val Arg Gly Asp Gln Val Glu Gln Ser Pro Ser Ala Leu Ser           
            20                  25                  30                    

ctc cac gag gga acc ggt tct gct ctg aga tgc aat ttt acg acc acc        144
Leu His Glu Gly Thr Gly Ser Ala Leu Arg Cys Asn Phe Thr Thr Thr           
        35                  40                  45                        

atg agg gct gtg cag tgg ttc caa cag aat tcc agg ggc agc ctc atc        192
Met Arg Ala Val Gln Trp Phe Gln Gln Asn Ser Arg Gly Ser Leu Ile           
    50                  55                  60                            

aat ctg ttc tac ttg gct tca gga aca aag gag aat ggg agg tta aag        240
Asn Leu Phe Tyr Leu Ala Ser Gly Thr Lys Glu Asn Gly Arg Leu Lys           
65                  70                  75                  80            

tca aca ttc aat tct aag gag agc tac agc acc ctg cac atc agg gat        288
Ser Thr Phe Asn Ser Lys Glu Ser Tyr Ser Thr Leu His Ile Arg Asp           
                85                  90                  95                

gcc cag ctg gag gac tca ggc act tac ttc tgt gct gcc gta atg aat        336
Ala Gln Leu Glu Asp Ser Gly Thr Tyr Phe Cys Ala Ala Val Met Asn           
            100                 105                 110                   

aca gaa ggt gca gat aga ctc acc ttt ggg aaa gga act cag ctg atc        384
Thr Glu Gly Ala Asp Arg Leu Thr Phe Gly Lys Gly Thr Gln Leu Ile           
        115                 120                 125                       

atc cag ccc tac atc cag aac cca gaa cct gct gtg tac cag tta aaa        432
Ile Gln Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys           
    130                 135                 140                           

gat cct cgg tct cag gac agc acc ctc tgc ctg ttc acc gac ttt gac        480
Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp           
145                 150                 155                 160           

tcc caa atc aat gtg ccg aaa acc atg gaa tct gga acg ttc atc act        528
Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr           
                165                 170                 175               

gac aaa act gtg ctg gac atg aaa gct atg gat tcc aag agc aat ggg        576
Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly           
            180                 185                 190                   

gcc att gcc tgg agc aac cag aca agc ttc acc tgc caa gat atc ttc        624
Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe           
        195                 200                 205                       

aaa gag acc aac gcc acc tac ccc agt tca gac gtt ccc tgt gat gcc        672
Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala           
    210                 215                 220                           

acg ttg act gag aaa agc ttt gaa aca gat atg aac cta aac ttt caa        720
Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln           
225                 230                 235                 240           

aac ctg tca gtt atg gga ctc cga atc ctc ctg ctg aaa gta gcc gga        768
Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly           
                245                 250                 255               

ttt aac ctg ctc atg acg ctg agg ctg tgg tcc tga                        804
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser                               
            260                 265                                       


<210>  68
<211>  267
<212>  PRT
<213>  mouse

<400>  68

Met Gln Arg Asn Leu Gly Ala Val Leu Gly Ile Leu Trp Val Gln Ile 
1               5                   10                  15      


Cys Trp Val Arg Gly Asp Gln Val Glu Gln Ser Pro Ser Ala Leu Ser 
            20                  25                  30          


Leu His Glu Gly Thr Gly Ser Ala Leu Arg Cys Asn Phe Thr Thr Thr 
        35                  40                  45              


Met Arg Ala Val Gln Trp Phe Gln Gln Asn Ser Arg Gly Ser Leu Ile 
    50                  55                  60                  


Asn Leu Phe Tyr Leu Ala Ser Gly Thr Lys Glu Asn Gly Arg Leu Lys 
65                  70                  75                  80  


Ser Thr Phe Asn Ser Lys Glu Ser Tyr Ser Thr Leu His Ile Arg Asp 
                85                  90                  95      


Ala Gln Leu Glu Asp Ser Gly Thr Tyr Phe Cys Ala Ala Val Met Asn 
            100                 105                 110         


Thr Glu Gly Ala Asp Arg Leu Thr Phe Gly Lys Gly Thr Gln Leu Ile 
        115                 120                 125             


Ile Gln Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265         


<210>  69
<211>  267
<212>  PRT
<213>  mouse

<400>  69

Met Gln Arg Asn Leu Gly Ala Val Leu Gly Ile Leu Trp Val Gln Ile 
1               5                   10                  15      


Cys Trp Val Arg Gly Asp Gln Val Glu Gln Ser Pro Ser Ala Leu Ser 
            20                  25                  30          


Leu His Glu Gly Thr Gly Ser Ala Leu Arg Cys Asn Phe Thr Thr Thr 
        35                  40                  45              


Met Arg Ala Val Gln Trp Phe Gln Gln Asn Ser Arg Gly Ser Leu Ile 
    50                  55                  60                  


Asn Leu Phe Tyr Leu Ala Ser Gly Thr Lys Glu Asn Gly Arg Leu Lys 
65                  70                  75                  80  


Ser Thr Phe Asn Ser Lys Glu Ser Tyr Ser Thr Leu His Ile Arg Asp 
                85                  90                  95      


Ala Gln Leu Glu Asp Ser Gly Thr Tyr Phe Cys Ala Ala Val Met Asn 
            100                 105                 110         


Thr Glu Gly Ala Asp Arg Leu Thr Phe Gly Lys Gly Thr Gln Leu Ile 
        115                 120                 125             


Ile Gln Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265         


<210>  70
<211>  29
<212>  PRT
<213>  human

<400>  70

Ser Val Leu Leu Tyr Gln Lys Pro Asn Arg Asp Ile Cys Gln Ser Gly 
1               5                   10                  15      


Thr Ser Leu Lys Ile Gln Cys Val Ala Asp Ser Gln Val 
            20                  25                  


<210>  71
<211>  23
<212>  PRT
<213>  human

<400>  71

Val Ser Met Phe Trp Tyr Gln Gln Phe Gln Glu Gln Ser Leu Met Leu 
1               5                   10                  15      


Met Ala Thr Ala Asn Glu Gly 
            20              


<210>  72
<211>  19
<212>  PRT
<213>  human

<400>  72

Ser Glu Ala Thr Tyr Glu Ser Gly Phe Thr Lys Asp Lys Phe Pro Ile 
1               5                   10                  15      


Ser Arg Pro 
            


<210>  73
<211>  25
<212>  PRT
<213>  human

<400>  73

Asn Leu Thr Phe Ser Thr Leu Thr Val Asn Asn Ala Arg Pro Gly Asp 
1               5                   10                  15      


Ser Ser Ile Tyr Phe Cys Ser Ser Arg 
            20                  25  


