                         SEQUENCE LISTING

<110>  Marsh, Henry C.
       Smith, Richard J.H.
       Zhang, Yuzhou
      	 
<120>  Treatment of Chronic Nephropathies Using Soluble Complement Receptor Type I (sCR1)

<130>  CDX-455.1 PCT

<140>  (to be assigned)
<141>  (filed concurrently herewith)

<150>  US 61383004
<151>  2010-09-15

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  1931
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1931)
<223>  soluble CR1 polypeptide

<400>  1

Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn Leu 
1               5                   10                  15      


Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys 
            20                  25                  30          


Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn 
        35                  40                  45              


Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg 
    50                  55                  60                  


Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu 
                85                  90                  95      


Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile 
            100                 105                 110         


Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro 
        115                 120                 125             


Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
    130                 135                 140                 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
                165                 170                 175     


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
            180                 185                 190         


Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val 
        195                 200                 205             


Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg 
    210                 215                 220                 


Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln 
225                 230                 235                 240 


Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys 
                245                 250                 255     


Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys 
            260                 265                 270         


Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly 
        275                 280                 285             


Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp 
    290                 295                 300                 


Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe 
305                 310                 315                 320 


Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln 
                325                 330                 335     


Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys 
            340                 345                 350         


Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp 
        355                 360                 365             


Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro 
    370                 375                 380                 


Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro 
385                 390                 395                 400 


Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly 
                405                 410                 415     


Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp 
            420                 425                 430         


Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile 
        435                 440                 445             


Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys 
    450                 455                 460                 


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
465                 470                 475                 480 


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
                485                 490                 495     


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
            500                 505                 510         


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
        515                 520                 525             


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
    530                 535                 540                 


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala 
545                 550                 555                 560 


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
                565                 570                 575     


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
            580                 585                 590         


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser 
        595                 600                 605             


Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
    610                 615                 620                 


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
625                 630                 635                 640 


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
                645                 650                 655     


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
            660                 665                 670         


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
        675                 680                 685             


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
    690                 695                 700                 


Val Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg 
705                 710                 715                 720 


Asp Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu 
                725                 730                 735     


Pro Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln 
            740                 745                 750         


Gly Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp 
        755                 760                 765             


Asp Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn 
    770                 775                 780                 


Leu Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln 
785                 790                 795                 800 


Leu Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser 
                805                 810                 815     


Leu Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser 
            820                 825                 830         


Pro Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val 
        835                 840                 845             


Phe Pro Phe Gly Lys Ala Val Asn Tyr Thr Cys Asp Pro His Pro Asp 
    850                 855                 860                 


Arg Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr 
865                 870                 875                 880 


Ser Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys 
                885                 890                 895     


Gly Ile Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys 
            900                 905                 910         


Leu Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu 
        915                 920                 925             


Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr 
    930                 935                 940                 


Cys Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg 
945                 950                 955                 960 


Lys Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val 
                965                 970                 975     


Ile Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr 
            980                 985                 990         


Gly His Arg Leu Ile Gly His Ser  Ser Ala Glu Cys Ile  Leu Ser Gly 
        995                 1000                 1005             


Asn Thr  Ala His Trp Ser Thr  Lys Pro Pro Ile Cys  Gln Arg Ile 
    1010                 1015                 1020             


Pro Cys  Gly Leu Pro Pro Thr  Ile Ala Asn Gly Asp  Phe Ile Ser 
    1025                 1030                 1035             


Thr Asn  Arg Glu Asn Phe His  Tyr Gly Ser Val Val  Thr Tyr Arg 
    1040                 1045                 1050             


Cys Asn  Leu Gly Ser Arg Gly  Arg Lys Val Phe Glu  Leu Val Gly 
    1055                 1060                 1065             


Glu Pro  Ser Ile Tyr Cys Thr  Ser Asn Asp Asp Gln  Val Gly Ile 
    1070                 1075                 1080             


Trp Ser  Gly Pro Ala Pro Gln  Cys Ile Ile Pro Asn  Lys Cys Thr 
    1085                 1090                 1095             


Pro Pro  Asn Val Glu Asn Gly  Ile Leu Val Ser Asp  Asn Arg Ser 
    1100                 1105                 1110             


Leu Phe  Ser Leu Asn Glu Val  Val Glu Phe Arg Cys  Gln Pro Gly 
    1115                 1120                 1125             


Phe Val  Met Lys Gly Pro Arg  Arg Val Lys Cys Gln  Ala Leu Asn 
    1130                 1135                 1140             


Lys Trp  Glu Pro Glu Leu Pro  Ser Cys Ser Arg Val  Cys Gln Pro 
    1145                 1150                 1155             


Pro Pro  Glu Ile Leu His Gly  Glu His Thr Pro Ser  His Gln Asp 
    1160                 1165                 1170             


Asn Phe  Ser Pro Gly Gln Glu  Val Phe Tyr Ser Cys  Glu Pro Gly 
    1175                 1180                 1185             


Tyr Asp  Leu Arg Gly Ala Ala  Ser Leu His Cys Thr  Pro Gln Gly 
    1190                 1195                 1200             


Asp Trp  Ser Pro Glu Ala Pro  Arg Cys Ala Val Lys  Ser Cys Asp 
    1205                 1210                 1215             


Asp Phe  Leu Gly Gln Leu Pro  His Gly Arg Val Leu  Phe Pro Leu 
    1220                 1225                 1230             


Asn Leu  Gln Leu Gly Ala Lys  Val Ser Phe Val Cys  Asp Glu Gly 
    1235                 1240                 1245             


Phe Arg  Leu Lys Gly Ser Ser  Val Ser His Cys Val  Leu Val Gly 
    1250                 1255                 1260             


Met Arg  Ser Leu Trp Asn Asn  Ser Val Pro Val Cys  Glu His Ile 
    1265                 1270                 1275             


Phe Cys  Pro Asn Pro Pro Ala  Ile Leu Asn Gly Arg  His Thr Gly 
    1280                 1285                 1290             


Thr Pro  Ser Gly Asp Ile Pro  Tyr Gly Lys Glu Ile  Ser Tyr Thr 
    1295                 1300                 1305             


Cys Asp  Pro His Pro Asp Arg  Gly Met Thr Phe Asn  Leu Ile Gly 
    1310                 1315                 1320             


Glu Ser  Thr Ile Arg Cys Thr  Ser Asp Pro His Gly  Asn Gly Val 
    1325                 1330                 1335             


Trp Ser  Ser Pro Ala Pro Arg  Cys Glu Leu Ser Val  Arg Ala Gly 
    1340                 1345                 1350             


His Cys  Lys Thr Pro Glu Gln  Phe Pro Phe Ala Ser  Pro Thr Ile 
    1355                 1360                 1365             


Pro Ile  Asn Asp Phe Glu Phe  Pro Val Gly Thr Ser  Leu Asn Tyr 
    1370                 1375                 1380             


Glu Cys  Arg Pro Gly Tyr Phe  Gly Lys Met Phe Ser  Ile Ser Cys 
    1385                 1390                 1395             


Leu Glu  Asn Leu Val Trp Ser  Ser Val Glu Asp Asn  Cys Arg Arg 
    1400                 1405                 1410             


Lys Ser  Cys Gly Pro Pro Pro  Glu Pro Phe Asn Gly  Met Val His 
    1415                 1420                 1425             


Ile Asn  Thr Asp Thr Gln Phe  Gly Ser Thr Val Asn  Tyr Ser Cys 
    1430                 1435                 1440             


Asn Glu  Gly Phe Arg Leu Ile  Gly Ser Pro Ser Thr  Thr Cys Leu 
    1445                 1450                 1455             


Val Ser  Gly Asn Asn Val Thr  Trp Asp Lys Lys Ala  Pro Ile Cys 
    1460                 1465                 1470             


Glu Ile  Ile Ser Cys Glu Pro  Pro Pro Thr Ile Ser  Asn Gly Asp 
    1475                 1480                 1485             


Phe Tyr  Ser Asn Asn Arg Thr  Ser Phe His Asn Gly  Thr Val Val 
    1490                 1495                 1500             


Thr Tyr  Gln Cys His Thr Gly  Pro Asp Gly Glu Gln  Leu Phe Glu 
    1505                 1510                 1515             


Leu Val  Gly Glu Arg Ser Ile  Tyr Cys Thr Ser Lys  Asp Asp Gln 
    1520                 1525                 1530             


Val Gly  Val Trp Ser Ser Pro  Pro Pro Arg Cys Ile  Ser Thr Asn 
    1535                 1540                 1545             


Lys Cys  Thr Ala Pro Glu Val  Glu Asn Ala Ile Arg  Val Pro Gly 
    1550                 1555                 1560             


Asn Arg  Ser Phe Phe Ser Leu  Thr Glu Ile Ile Arg  Phe Arg Cys 
    1565                 1570                 1575             


Gln Pro  Gly Phe Val Met Val  Gly Ser His Thr Val  Gln Cys Gln 
    1580                 1585                 1590             


Thr Asn  Gly Arg Trp Gly Pro  Lys Leu Pro His Cys  Ser Arg Val 
    1595                 1600                 1605             


Cys Gln  Pro Pro Pro Glu Ile  Leu His Gly Glu His  Thr Leu Ser 
    1610                 1615                 1620             


His Gln  Asp Asn Phe Ser Pro  Gly Gln Glu Val Phe  Tyr Ser Cys 
    1625                 1630                 1635             


Glu Pro  Ser Tyr Asp Leu Arg  Gly Ala Ala Ser Leu  His Cys Thr 
    1640                 1645                 1650             


Pro Gln  Gly Asp Trp Ser Pro  Glu Ala Pro Arg Cys  Thr Val Lys 
    1655                 1660                 1665             


Ser Cys  Asp Asp Phe Leu Gly  Gln Leu Pro His Gly  Arg Val Leu 
    1670                 1675                 1680             


Leu Pro  Leu Asn Leu Gln Leu  Gly Ala Lys Val Ser  Phe Val Cys 
    1685                 1690                 1695             


Asp Glu  Gly Phe Arg Leu Lys  Gly Arg Ser Ala Ser  His Cys Val 
    1700                 1705                 1710             


Leu Ala  Gly Met Lys Ala Leu  Trp Asn Ser Ser Val  Pro Val Cys 
    1715                 1720                 1725             


Glu Gln  Ile Phe Cys Pro Asn  Pro Pro Ala Ile Leu  Asn Gly Arg 
    1730                 1735                 1740             


His Thr  Gly Thr Pro Phe Gly  Asp Ile Pro Tyr Gly  Lys Glu Ile 
    1745                 1750                 1755             


Ser Tyr  Ala Cys Asp Thr His  Pro Asp Arg Gly Met  Thr Phe Asn 
    1760                 1765                 1770             


Leu Ile  Gly Glu Ser Ser Ile  Arg Cys Thr Ser Asp  Pro Gln Gly 
    1775                 1780                 1785             


Asn Gly  Val Trp Ser Ser Pro  Ala Pro Arg Cys Glu  Leu Ser Val 
    1790                 1795                 1800             


Pro Ala  Ala Cys Pro His Pro  Pro Lys Ile Gln Asn  Gly His Tyr 
    1805                 1810                 1815             


Ile Gly  Gly His Val Ser Leu  Tyr Leu Pro Gly Met  Thr Ile Ser 
    1820                 1825                 1830             


Tyr Ile  Cys Asp Pro Gly Tyr  Leu Leu Val Gly Lys  Gly Phe Ile 
    1835                 1840                 1845             


Phe Cys  Thr Asp Gln Gly Ile  Trp Ser Gln Leu Asp  His Tyr Cys 
    1850                 1855                 1860             


Lys Glu  Val Asn Cys Ser Phe  Pro Leu Phe Met Asn  Gly Ile Ser 
    1865                 1870                 1875             


Lys Glu  Leu Glu Met Lys Lys  Val Tyr His Tyr Gly  Asp Tyr Val 
    1880                 1885                 1890             


Thr Leu  Lys Cys Glu Asp Gly  Tyr Thr Leu Glu Gly  Ser Pro Trp 
    1895                 1900                 1905             


Ser Gln  Cys Gln Ala Asp Asp  Arg Trp Asp Pro Pro  Leu Ala Lys 
    1910                 1915                 1920             


Cys Thr  Ser Arg Ala His Asp  Ala 
    1925                 1930     






