                         SEQUENCE LISTING

<110>  Santaris Pharma
 
<120>  COMPOUNDS FOR THE MODULATION OF AURORA KINASE B EXPRESSION

<130>  1110WO

<150>  EP10176416.5
<151>  2010-09-13

<150>  US61/382039
<151>  2010-09-13

<160>  39    

<170>  PatentIn version 3.3

<210>  1
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  1
ggtgacaggc tctttc                                                     16


<210>  2
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage
<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<400>  2
aggacaagtg cagatg                                                     16


<210>  3
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage
<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<400>  3
cgcccaatct caaagt                                                     16


<210>  4
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>   Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage
<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<400>  4
ttgcctttgc ccagag                                                     16


<210>  5
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methylcytosine

<400>  5
ttgcccagag gacgcc                                                     16


<210>  6
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage
<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  6
cccgagccaa gtacac                                                     16


<210>  7
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methylcytosine

<400>  7
gacttgaaga ggacct                                                     16


<210>  8
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  8
tagaatcaag tagatc                                                     16


<210>  9
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<400>  9
tgccaactcc tccatg                                                     16


<210>  10
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<400>  10
ggctttatgt ctctgt                                                     16


<210>  11
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<400>  11
agccctaaga gcagat                                                     16


<210>  12
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  12
gtcagcaatc ttcagc                                                     16


<210>  13
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methylcytosine

<400>  13
catgcacaga ccagcc                                                     16


<210>  14
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<400>  14
cctcaatcat ctctgg                                                     16


<210>  15
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methylcytosine

<400>  15
ctccaatgca ccacag                                                     16


<210>  16
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  16
tcatagcaaa gcactc                                                     16


<210>  17
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methylcytosine

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methylcytosine

<400>  17
ggaactttag gtccac                                                     16


<210>  18
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methylcytosine

<400>  18
ggttatgcct gagcag                                                     16


<210>  19
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer design or LNA oligomer compound


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Internucleoside linkage, preferably phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  DNA

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methylcytosine

<400>  19
ggaggcagca ccctcc                                                     16


<210>  20
<211>  1253
<212>  DNA
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (1)..(1253)
<223>  cDNA

<220>
<221>  misc_feature
<222>  (1)..(1253)
<223>  cDNA

<400>  20
gggcggccgg gagagtagca gtgccttgga ccccagctct cctccccctt tctctctaag     60

gatggcccag aaggagaact cctacccctg gccctacggc cgacagacgg ctccatctgg    120

cctgagcacc ctgccccagc gagtcctccg gaaagagcct gtcaccccat ctgcacttgt    180

cctcatgagc cgctccaatg tccagcccac agctgcccct ggccagaagg tgatggagaa    240

tagcagtggg acacccgaca tcttaacgcg gcacttcaca attgatgact ttgagattgg    300

gcgtcctctg ggcaaaggca agtttggaaa cgtgtacttg gctcgggaga agaaaagcca    360

tttcatcgtg gcgctcaagg tcctcttcaa gtcccagata gagaaggagg gcgtggagca    420

tcagctgcgc agagagatcg aaatccaggc ccacctgcac catcccaaca tcctgcgtct    480

ctacaactat ttttatgacc ggaggaggat ctacttgatt ctagagtatg ccccccgcgg    540

ggagctctac aaggagctgc agaagagctg cacatttgac gagcagcgaa cagccacgat    600

catggaggag ttggcagatg ctctaatgta ctgccatggg aagaaggtga ttcacagaga    660

cataaagcca gaaaatctgc tcttagggct caagggagag ctgaagattg ctgacttcgg    720

ctggtctgtg catgcgccct ccctgaggag gaagacaatg tgtggcaccc tggactacct    780

gcccccagag atgattgagg ggcgcatgca caatgagaag gtggatctgt ggtgcattgg    840

agtgctttgc tatgagctgc tggtggggaa cccacccttt gagagtgcat cacacaacga    900

gacctatcgc cgcatcgtca aggtggacct aaagttcccc gcttccgtgc ccatgggagc    960

ccaggacctc atctccaaac tgctcaggca taacccctcg gaacggctgc ccctggccca   1020

ggtctcagcc cacccttggg tccgggccaa ctctcggagg gtgctgcctc cctctgccct   1080

tcaatctgtc gcctgatggt ccctgtcatt cactcgggtg cgtgtgtttg tatgtctgtg   1140

tatgtatagg ggaaagaagg gatccctaac tgttccctta tctgttttct acctcctcct   1200

ttgtttaata aaggctgaag ctttttgtac tcatgaaaaa aaaaaaaaaa aaa          1253


<210>  21
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  21
ggtgacaggc tctttc                                                     16


<210>  22
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  22
aggacaagtg cagatg                                                     16


<210>  23
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  23
cgcccaatct caaagt                                                     16


<210>  24
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  24
ttgcctttgc ccagag                                                     16


<210>  25
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  25
ttgcccagag gacgcc                                                     16


<210>  26
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  26
cccgagccaa gtacac                                                     16


<210>  27
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  27
gacttgaaga ggacct                                                     16


<210>  28
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)f


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  28
tagaatcaag tagatc                                                     16


<210>  29
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  29
tgccaactcc tccatg                                                     16


<210>  30
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  30
ggctttatgt ctctgt                                                     16


<210>  31
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  31
agccctaaga gcagat                                                     16


<210>  32
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  32
gtcagcaatc ttcagc                                                     16


<210>  33
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  33
catgcacaga ccagcc                                                     16


<210>  34
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  34
cctcaatcat ctctgg                                                     16


<210>  35
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  35
ctccaatgca ccacag                                                     16


<210>  36
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  36
tcatagcaaa gcactc                                                     16


<210>  37
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  37
ggaactttag gtccac                                                     16


<210>  38
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  38
ggttatgcct gagcag                                                     16


<210>  39
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  Oligomer sequence motif - sequence of monomers (nucleotides)


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  DNA

<400>  39
ggaggcagca ccctcc                                                     16


