SEQUENCE LISTING


<110> KUNDRA, VIKAS

<120> SOMATOSTATIN RECEPTOR-BASED THERAPY

<130> UTFC.P1065WO

<140> UNKNOWN
<141> 2011-09-08

<150> 61/380,920
<151> 2010-09-08

<160> 22                            

<170> PatentIn Ver. 2.1

<210> 1
<211> 4000
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (275)..(1450)

<400> 1
tgcggtgctc ccacatcctg gcctctcctc tccacagtcg cctgtgcccg ggcaccccgg 60    

agctgcaaac tgcagagccc aggcaaccgc tgggctgtgc gccccgccgg cgccggtagg 120   

agccgcgctc cccgcagcgg ttgcgctcta cccggaggcg ctgggcggct gcgggctgca 180   

ggcaagcggt cgggtgggga gggagggcgc aggcggcggg tgcgcgagga gaaagcccca 240   

gccctggcag ccccactggc ccccctcagc tggg atg ttc ccc aat ggc acc gcc 295   
                                      Met Phe Pro Asn Gly Thr Ala
                                        1               5        

tcc tct cct tcc tcc tct cct agc ccc agc ccg ggc agc tgc ggc gaa   343   
Ser Ser Pro Ser Ser Ser Pro Ser Pro Ser Pro Gly Ser Cys Gly Glu
         10                  15                  20            

ggc ggc ggc agc agg ggc ccc ggg gcc ggc gct gcg gac ggc atg gag   391   
Gly Gly Gly Ser Arg Gly Pro Gly Ala Gly Ala Ala Asp Gly Met Glu
     25                  30                  35                

gag cca ggg cga aat gcg tcc cag aac ggg acc ttg agc gag ggc cag   439   
Glu Pro Gly Arg Asn Ala Ser Gln Asn Gly Thr Leu Ser Glu Gly Gln
 40                  45                  50                  55

ggc agc gcc atc ctg atc tct ttc atc tac tcc gtg gtg tgc ctg gtg   487   
Gly Ser Ala Ile Leu Ile Ser Phe Ile Tyr Ser Val Val Cys Leu Val
                 60                  65                  70    

ggg ctg tgt ggg aac tct atg gtc atc tac gtg atc ctg cgc tat gcc   535   
Gly Leu Cys Gly Asn Ser Met Val Ile Tyr Val Ile Leu Arg Tyr Ala
             75                  80                  85        

aag atg aag acg gcc acc aac atc tac atc cta aat ctg gcc att gct   583   
Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Leu Asn Leu Ala Ile Ala
         90                  95                 100            

gat gag ctg ctc atg ctc agc gtg ccc ttc cta gtc acc tcc acg ttg   631   
Asp Glu Leu Leu Met Leu Ser Val Pro Phe Leu Val Thr Ser Thr Leu
    105                 110                 115                

ttg cgc cac tgg ccc ttc ggt gcg ctg ctc tgc cgc ctc gtg ctc agc   679   
Leu Arg His Trp Pro Phe Gly Ala Leu Leu Cys Arg Leu Val Leu Ser
120                 125                 130                 135

gtg gac gcg gtc aac atg ttc acc agc atc tac tgt ctg act gtg ctc   727   
Val Asp Ala Val Asn Met Phe Thr Ser Ile Tyr Cys Leu Thr Val Leu
                140                 145                 150    

agc gtg gac cgc tac gtg gcc gtg gtg cat ccc atc aag gcg gcc cgc   775   
Ser Val Asp Arg Tyr Val Ala Val Val His Pro Ile Lys Ala Ala Arg
            155                 160                 165        

tac cgc cgg ccc acc gtg gcc aag gta gta aac ctg ggc gtg tgg gtg   823   
Tyr Arg Arg Pro Thr Val Ala Lys Val Val Asn Leu Gly Val Trp Val
        170                 175                 180            

cta tcg ctg ctc gtc atc ctg ccc atc gtg gtc ttc tct cgc acc gcg   871   
Leu Ser Leu Leu Val Ile Leu Pro Ile Val Val Phe Ser Arg Thr Ala
    185                 190                 195                

gcc aac agc gac ggc acg gtg gct tgc aac atg ctc atg cca gag ccc   919   
Ala Asn Ser Asp Gly Thr Val Ala Cys Asn Met Leu Met Pro Glu Pro
200                 205                 210                 215

gct caa cgc tgg ctg gtg ggc ttc gtg ttg tac aca ttt ctc atg ggc   967   
Ala Gln Arg Trp Leu Val Gly Phe Val Leu Tyr Thr Phe Leu Met Gly
                220                 225                 230    

ttc ctg ctg ccc gtg ggg gct atc tgc ctg tgc tac gtg ctc atc att   1015  
Phe Leu Leu Pro Val Gly Ala Ile Cys Leu Cys Tyr Val Leu Ile Ile
            235                 240                 245        

gct aag atg cgc atg gtg gcc ctc aag gcc ggc tgg cag cag cgc aag   1063  
Ala Lys Met Arg Met Val Ala Leu Lys Ala Gly Trp Gln Gln Arg Lys
        250                 255                 260            

cgc tcg gag cgc aag atc acc tta atg gtg atg atg gtg gtg atg gtg   1111  
Arg Ser Glu Arg Lys Ile Thr Leu Met Val Met Met Val Val Met Val
    265                 270                 275                

ttt gtc atc tgc tgg atg cct ttc tac gtg gtg cag ctg gtc aac gtg   1159  
Phe Val Ile Cys Trp Met Pro Phe Tyr Val Val Gln Leu Val Asn Val
280                 285                 290                 295

ttt gct gag cag gac gac gcc acg gtg agt cag ctg tcg gtc atc ctc   1207  
Phe Ala Glu Gln Asp Asp Ala Thr Val Ser Gln Leu Ser Val Ile Leu
                300                 305                 310    

ggc tat gcc aac agc tgc gcc aac ccc atc ctc tat ggc ttt ctc tca   1255  
Gly Tyr Ala Asn Ser Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser
            315                 320                 325        

gac aac ttc aag cgc tct ttc caa cgc atc cta tgc ctc agc tgg atg   1303  
Asp Asn Phe Lys Arg Ser Phe Gln Arg Ile Leu Cys Leu Ser Trp Met
        330                 335                 340            

gac aac gcc gcg gag gag ccg gtt gac tat tac gcc acc gcg ctc aag   1351  
Asp Asn Ala Ala Glu Glu Pro Val Asp Tyr Tyr Ala Thr Ala Leu Lys
    345                 350                 355                

agc cgt gcc tac agt gtg gaa gac ttc caa cct gag aac ctg gag tcc   1399  
Ser Arg Ala Tyr Ser Val Glu Asp Phe Gln Pro Glu Asn Leu Glu Ser
360                 365                 370                 375

ggc ggc gtc ttc cgt aat ggc acc tgc acg tcc cgg atc acg acg ctc   1447  
Gly Gly Val Phe Arg Asn Gly Thr Cys Thr Ser Arg Ile Thr Thr Leu
                380                 385                 390    

tga gcccgggcca cgcaggggct ctgagcccgg gccacgcagg ggccctgagc        1500  
                                                          

caaaagaggg ggagaatgag aagggaaggc cgggtgcgaa agggacggta tccagggcgc 1560  

cagggtgctg tcgggataac gtggggctag gacactgaca gcctttgatg gaggaaccca 1620  

agaaaggcgc gcgacaatgg tagaagtgag agctttgctt ataaactggg aaggctttca 1680  

ggctaccttt ttctgggtct cccactttct gttccttcct ccactgcgct tactcctctg 1740  

accctccttc tattttccct accctgcaac ttctatcctt tcttccgcac cgtcccgcca 1800  

gtgcagatca cgaactcatt aacaactcat tctgatcctc agcccctcca gtcgttattt 1860  

ctgtttgttt aagctgagcc acggataccg ccacgggttt ccctcggcgt tagtccctag 1920  

ccgcgcgggg ccgctgtcca ggttctgtct ggtgccccta ctggagtccc gggaatgacc 1980  

gctctccctt tgcgcagccc taccttaagg aaagttggac ttgagaaaga tctaagcagc 2040  

tggtcttttc tcctactctt gggtgaaggt gcatctttcc ctgccctccc ctgtccccct 2100  

ctcgccgccc gcccgccacc accactctca ctccacccag agtagagcca ggtgcttagt 2160  

aaaataggtc ccgcgcttcg aactccaggc tttctggagt tcccacccaa gccctccttt 2220  

ggagcaaaga aggagctgag aacaagccga atgaggagtt tttataagat tgcggggtcg 2280  

gagtgtgggc gcgtaatagg aatcaccctc ctactgcgcg ttttcaaaga ccaagcgctg 2340  

ggcgctcccg ggccgcgcgt ctgcgttagg cagggcaggg tagtgcaggg cacaccttcc 2400  

ccggggttcg gggttcgggg ttcggttgca gggctgcagc ccgccttggc tttctccctc 2460  

acccaagttt ccggaggagc cgacctaaaa gtaacaatag ataaggtttc ctgctccagt 2520  

gtatctcaaa agaccgggcg ccaggggcgg gggacctagg gcgacgtctt cagagtccgc 2580  

cagtgttggc ggtgtcgccg caacctgcag gctcccgagt ggggcctgcc tggtctctag 2640  

agggttgctg cctttcaagc ggtgcctaag aagttatttt cttgtttaac atatatattt 2700  

attaatttat ttgtcgtgtt ggaaaatgtg tctctgcttt ccttttctct gcttgcctag 2760  

ccccaggtct tttctttggg accctggggg cgggcatgga agtggaagta ggggcaagct 2820  

cttgccccac tccctggcca tctcaacgcc tctcctcaat gctgggccct cttatctcat 2880  

cctttcctct agcttttcta tttttgattg tgttgagtga agtttggaga tttttcatac 2940  

ttttcttact atagtctctt gtttgtctta ttaggataat acataaatga taatgtgggt 3000  

tatcctcctc tccatgcaca gtggaaagtc ctgaactcct ggctttccag gagacatata 3060  

taggggaaca tcaccctata tataatttga gtgtatatat atttatatat atgatgtgga 3120  

catatgtata cttatcttgc tccattgtca tgagtccatg agtctaagta tagccactga 3180  

tggtgacagg tgtgagtctg gctggaacac tttcagtttc aggagtgcaa gcagcactca 3240  

aacctggagc tgaggaatct aattcagaca gagactttaa tcactgctga agatgcccct 3300  

gctccctctg ggttccagca gaggtgattc ttacatatga tccagttaac atcatcactt 3360  

tttttgagga cattgaaagt gaaataattt gtgtctgtgt ttaatattac caactacatt 3420  

ggaagcctga gcagggcgag gaccaataat tttaattatt tatatttcct gtattgcttt 3480  

agtatgctgg cttgtacata gtaggcacta aatacatgtt tgttggttga ttgtttaagc 3540  

cagagtgtat tacaacaatc tggagatact aaatctgggg ttctcaggtt cactcattga 3600  

catgatatac aatggttaaa atcactattg aaaaatacgt tttgtgtata tttgcttcaa 3660  

caactttgtg ctttcctgaa agcagtaacc aagagttaag atatccctaa tgttttgctt 3720  

aaactaatga acaaatatgc tttgggtcat aaatcagaaa gtttagatct gtcccttaat 3780  

aaaaatatat attactactc ctttggaaaa tagattttta atggttaaga actgtgaaat 3840  

ttacaaatca aaatcttaat cattatcctt ctaagaggat acaaatttag tgctcttaac 3900  

ttgttaccat tgtaatatta actaaataaa cagatgtatt atgctgttaa aaaaaaaaaa 3960  

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                       4000  


<210> 2
<211> 391        
<212> PRT
<213> Homo sapiens

<400> 2
Met Phe Pro Asn Gly Thr Ala Ser Ser Pro Ser Ser Ser Pro Ser Pro  
  1               5                  10                  15      
Ser Pro Gly Ser Cys Gly Glu Gly Gly Gly Ser Arg Gly Pro Gly Ala  
             20                  25                  30          
Gly Ala Ala Asp Gly Met Glu Glu Pro Gly Arg Asn Ala Ser Gln Asn  
         35                  40                  45              
Gly Thr Leu Ser Glu Gly Gln Gly Ser Ala Ile Leu Ile Ser Phe Ile  
     50                  55                  60                  
Tyr Ser Val Val Cys Leu Val Gly Leu Cys Gly Asn Ser Met Val Ile  
 65                  70                  75                  80  
Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ala Thr Asn Ile Tyr  
                 85                  90                  95      
Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Leu Met Leu Ser Val Pro  
            100                 105                 110          
Phe Leu Val Thr Ser Thr Leu Leu Arg His Trp Pro Phe Gly Ala Leu  
        115                 120                 125              
Leu Cys Arg Leu Val Leu Ser Val Asp Ala Val Asn Met Phe Thr Ser  
    130                 135                 140                  
Ile Tyr Cys Leu Thr Val Leu Ser Val Asp Arg Tyr Val Ala Val Val  
145                 150                 155                 160  
His Pro Ile Lys Ala Ala Arg Tyr Arg Arg Pro Thr Val Ala Lys Val  
                165                 170                 175      
Val Asn Leu Gly Val Trp Val Leu Ser Leu Leu Val Ile Leu Pro Ile  
            180                 185                 190          
Val Val Phe Ser Arg Thr Ala Ala Asn Ser Asp Gly Thr Val Ala Cys  
        195                 200                 205              
Asn Met Leu Met Pro Glu Pro Ala Gln Arg Trp Leu Val Gly Phe Val  
    210                 215                 220                  
Leu Tyr Thr Phe Leu Met Gly Phe Leu Leu Pro Val Gly Ala Ile Cys  
225                 230                 235                 240  
Leu Cys Tyr Val Leu Ile Ile Ala Lys Met Arg Met Val Ala Leu Lys  
                245                 250                 255      
Ala Gly Trp Gln Gln Arg Lys Arg Ser Glu Arg Lys Ile Thr Leu Met  
            260                 265                 270          
Val Met Met Val Val Met Val Phe Val Ile Cys Trp Met Pro Phe Tyr  
        275                 280                 285              
Val Val Gln Leu Val Asn Val Phe Ala Glu Gln Asp Asp Ala Thr Val  
    290                 295                 300                  
Ser Gln Leu Ser Val Ile Leu Gly Tyr Ala Asn Ser Cys Ala Asn Pro  
305                 310                 315                 320  
Ile Leu Tyr Gly Phe Leu Ser Asp Asn Phe Lys Arg Ser Phe Gln Arg  
                325                 330                 335      
Ile Leu Cys Leu Ser Trp Met Asp Asn Ala Ala Glu Glu Pro Val Asp  
            340                 345                 350          
Tyr Tyr Ala Thr Ala Leu Lys Ser Arg Ala Tyr Ser Val Glu Asp Phe  
        355                 360                 365              
Gln Pro Glu Asn Leu Glu Ser Gly Gly Val Phe Arg Asn Gly Thr Cys  
    370                 375                 380                  
Thr Ser Arg Ile Thr Thr Leu                                      
385                 390                                          



<210> 3
<211> 2014
<212> DNA
<213> Mus musculus

<220> 
<221> CDS
<222> (426)..(1601)

<400> 3
gagacatcat tgacttgggg atctgaaggc ctgaaatctc caggtacagg tttaaagaac 60    

tggcaagcag gaaaggagct gctgacgcga tggtgccgct tattaatcat tcatcagtcc 120   

agagcctttc cacttaatgg atgtgccgcg ctgggctcta gcctcttggc ctctcctctc 180   

cactctccag tgtgcccagg acccccggag ctgcaagaga gacagcgctc aagcaagctg 240   

ccgctgggtg atgctcccgg cggcctcagt cggagccgcg ctcgccacag ctgctgcgct 300   

ctgccgggtg gcgccaggcg gcggtgagct gtgagcttgg ggccttgagc ctagggaggg 360   

cgcagacagc aagggcgcaa ggtgagcgcc ccagccggca gccgcaccgg cccacttcag 420   

ctggg atg ttc ccc aat ggc acc gcc tcc tct ccc tcc tct tct cca agc 470   
      Met Phe Pro Asn Gly Thr Ala Ser Ser Pro Ser Ser Ser Pro Ser
        1               5                  10                  15

ccc agc cca ggc agc tgc ggg gaa gga gcc tgc agc agg ggt ccg ggg   518   
Pro Ser Pro Gly Ser Cys Gly Glu Gly Ala Cys Ser Arg Gly Pro Gly
                 20                  25                  30    

tcc ggc gct gcg gac ggc atg gaa gag cct gga cga aac gct tcc cag   566   
Ser Gly Ala Ala Asp Gly Met Glu Glu Pro Gly Arg Asn Ala Ser Gln
             35                  40                  45        

aat ggg acc tta agc gag gga cag ggt agc gcc att ctc atc tct ttc   614   
Asn Gly Thr Leu Ser Glu Gly Gln Gly Ser Ala Ile Leu Ile Ser Phe
         50                  55                  60            

atc tac tcc gtg gta tgc ttg gtg gga ctg tgt ggg aac tct atg gtc   662   
Ile Tyr Ser Val Val Cys Leu Val Gly Leu Cys Gly Asn Ser Met Val
     65                  70                  75                

atc tat gtg atc ctg cgc tac gcc aag atg aag acc gct acc aac atc   710   
Ile Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ala Thr Asn Ile
 80                  85                  90                  95

tac att cta aac ctg gct att gct gat gag ctg ctc atg ctc agc gtg   758   
Tyr Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Leu Met Leu Ser Val
                100                 105                 110    

ccc ttt ctg gtc act tcc acg ctg ttg cgc cac tgg ccc ttc ggc gcg   806   
Pro Phe Leu Val Thr Ser Thr Leu Leu Arg His Trp Pro Phe Gly Ala
            115                 120                 125        

cta ctt tgc cgc ctg gtg ctc agc gtg gat gcg gtc aac atg ttc acc   854   
Leu Leu Cys Arg Leu Val Leu Ser Val Asp Ala Val Asn Met Phe Thr
        130                 135                 140            

agc atc tac tgt ctg act gtg ctt agt gtg gac cgc tat gtg gct gtg   902   
Ser Ile Tyr Cys Leu Thr Val Leu Ser Val Asp Arg Tyr Val Ala Val
    145                 150                 155                

gtg cac ccg atc aag gca gcg cgc tac cgt cgg ccc act gtg gcc aaa   950   
Val His Pro Ile Lys Ala Ala Arg Tyr Arg Arg Pro Thr Val Ala Lys
160                 165                 170                 175

gta gtg aac ctg ggc gtg tgg gtc ctg tca tta ctg gtt atc ttg ccc   998   
Val Val Asn Leu Gly Val Trp Val Leu Ser Leu Leu Val Ile Leu Pro
                180                 185                 190    

atc gtg gtc ttc tca cgc acc gca gcc aac agc gat ggc acg gta gcc   1046  
Ile Val Val Phe Ser Arg Thr Ala Ala Asn Ser Asp Gly Thr Val Ala
            195                 200                 205        

tgc aac atg ctc atg ccc gag ccc gcc cag cgc tgg ttg gtg ggc ttc   1094  
Cys Asn Met Leu Met Pro Glu Pro Ala Gln Arg Trp Leu Val Gly Phe
        210                 215                 220            

gtc tta tac aca ttt ctc atg ggc ttc ctg ctg cct gtc ggg gcc att   1142  
Val Leu Tyr Thr Phe Leu Met Gly Phe Leu Leu Pro Val Gly Ala Ile
    225                 230                 235                

tgc ctg tgt tat gtg ctc atc att gcc aag atg cgc atg gtg gcc ctc   1190  
Cys Leu Cys Tyr Val Leu Ile Ile Ala Lys Met Arg Met Val Ala Leu
240                 245                 250                 255

aag gct ggc tgg cag cag cgc aag cgc tca gag cgc aag atc act cta   1238  
Lys Ala Gly Trp Gln Gln Arg Lys Arg Ser Glu Arg Lys Ile Thr Leu
                260                 265                 270    

atg gtg atg atg gtg gtg atg gtt ttt gtc atc tgc tgg atg cct ttc   1286  
Met Val Met Met Val Val Met Val Phe Val Ile Cys Trp Met Pro Phe
            275                 280                 285        

tac gtg gta cag ctg gtc aac gtg ttc gcc gag caa gac gac gcc acc   1334  
Tyr Val Val Gln Leu Val Asn Val Phe Ala Glu Gln Asp Asp Ala Thr
        290                 295                 300            

gtg agc cag ttg tct gtc atc ctg ggc tat gcc aac agc tgt gcc aac   1382  
Val Ser Gln Leu Ser Val Ile Leu Gly Tyr Ala Asn Ser Cys Ala Asn
    305                 310                 315                

ccc atc ctc tac ggc ttc ctg tcg gac aac ttc aag cgc tct ttc cag   1430  
Pro Ile Leu Tyr Gly Phe Leu Ser Asp Asn Phe Lys Arg Ser Phe Gln
320                 325                 330                 335

cgc atc ctg tgc ctc agc tgg atg gat aac gct gcg gag gaa cca gtc   1478  
Arg Ile Leu Cys Leu Ser Trp Met Asp Asn Ala Ala Glu Glu Pro Val
                340                 345                 350    

gac tac tat gcc act gcc ctg aag agt cga gcc tac agc gtg gag gac   1526  
Asp Tyr Tyr Ala Thr Ala Leu Lys Ser Arg Ala Tyr Ser Val Glu Asp
            355                 360                 365        

ttc cag ccc gag aat ctg gag tct gga ggc gtt ttc cgt aat ggc acc   1574  
Phe Gln Pro Glu Asn Leu Glu Ser Gly Gly Val Phe Arg Asn Gly Thr
        370                 375                 380            

tgc gct tcc agg atc agc acg ctt tga ggccgggcac tgccgggagg         1621  
Cys Ala Ser Arg Ile Ser Thr Leu                          
    385                 390                              

gggggagtgg tcagaaagat ggagctggga agcgggtggg agggaatggt aacccgacac 1681  

caggtgctga agtcatagtg catgacagcg atgcagcgcc cctgcgctga accctgttcc 1741  

gctgcgcagg tcagcgggcc agactctttt cagagtggct acaagacagt ccctaatcac 1801  

cgctctcctt tcgcagagcc ttactgtcaa ggaagcacag ctcgaggatg tctaggcaac 1861  

ttgtcttttc tactctcaga gaaggaaggc acattttccc ttgggccctt cctctgctcc 1921  

actccatccc gagcagagct aggcgcttaa gaaaaagttc tgtgccctga tctccagtct 1981  

tggtatagta ccacacatat gcttctttgg agc                              2014  


<210> 4
<211> 391        
<212> PRT
<213> Mus musculus

<400> 4
Met Phe Pro Asn Gly Thr Ala Ser Ser Pro Ser Ser Ser Pro Ser Pro  
  1               5                  10                  15      
Ser Pro Gly Ser Cys Gly Glu Gly Ala Cys Ser Arg Gly Pro Gly Ser  
             20                  25                  30          
Gly Ala Ala Asp Gly Met Glu Glu Pro Gly Arg Asn Ala Ser Gln Asn  
         35                  40                  45              
Gly Thr Leu Ser Glu Gly Gln Gly Ser Ala Ile Leu Ile Ser Phe Ile  
     50                  55                  60                  
Tyr Ser Val Val Cys Leu Val Gly Leu Cys Gly Asn Ser Met Val Ile  
 65                  70                  75                  80  
Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ala Thr Asn Ile Tyr  
                 85                  90                  95      
Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Leu Met Leu Ser Val Pro  
            100                 105                 110          
Phe Leu Val Thr Ser Thr Leu Leu Arg His Trp Pro Phe Gly Ala Leu  
        115                 120                 125              
Leu Cys Arg Leu Val Leu Ser Val Asp Ala Val Asn Met Phe Thr Ser  
    130                 135                 140                  
Ile Tyr Cys Leu Thr Val Leu Ser Val Asp Arg Tyr Val Ala Val Val  
145                 150                 155                 160  
His Pro Ile Lys Ala Ala Arg Tyr Arg Arg Pro Thr Val Ala Lys Val  
                165                 170                 175      
Val Asn Leu Gly Val Trp Val Leu Ser Leu Leu Val Ile Leu Pro Ile  
            180                 185                 190          
Val Val Phe Ser Arg Thr Ala Ala Asn Ser Asp Gly Thr Val Ala Cys  
        195                 200                 205              
Asn Met Leu Met Pro Glu Pro Ala Gln Arg Trp Leu Val Gly Phe Val  
    210                 215                 220                  
Leu Tyr Thr Phe Leu Met Gly Phe Leu Leu Pro Val Gly Ala Ile Cys  
225                 230                 235                 240  
Leu Cys Tyr Val Leu Ile Ile Ala Lys Met Arg Met Val Ala Leu Lys  
                245                 250                 255      
Ala Gly Trp Gln Gln Arg Lys Arg Ser Glu Arg Lys Ile Thr Leu Met  
            260                 265                 270          
Val Met Met Val Val Met Val Phe Val Ile Cys Trp Met Pro Phe Tyr  
        275                 280                 285              
Val Val Gln Leu Val Asn Val Phe Ala Glu Gln Asp Asp Ala Thr Val  
    290                 295                 300                  
Ser Gln Leu Ser Val Ile Leu Gly Tyr Ala Asn Ser Cys Ala Asn Pro  
305                 310                 315                 320  
Ile Leu Tyr Gly Phe Leu Ser Asp Asn Phe Lys Arg Ser Phe Gln Arg  
                325                 330                 335      
Ile Leu Cys Leu Ser Trp Met Asp Asn Ala Ala Glu Glu Pro Val Asp  
            340                 345                 350          
Tyr Tyr Ala Thr Ala Leu Lys Ser Arg Ala Tyr Ser Val Glu Asp Phe  
        355                 360                 365              
Gln Pro Glu Asn Leu Glu Ser Gly Gly Val Phe Arg Asn Gly Thr Cys  
    370                 375                 380                  
Ala Ser Arg Ile Ser Thr Leu                                      
385                 390                                          



<210> 5
<211> 1769
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (361)..(1470)

<400> 5
cgcagccacc catgcgcgcg cgctcgcaag accaccagcg cccagagccc cagtctgagg 60    

cttggcgccg ggggtctgcg ggcgagggga gctctctacg tgcgaggggc tagcgggagc 120   

cggcacaaga gggtcgagga gccaggaacc ccaaacgtcc ggcgccaggc gctagccaag 180   

ctgctgcgcg ccccggcgcc cagctggctc ggggacagcc gctgggtgtc ggagaccgga 240   

gctagcggat tgcagcggaa aagcaaagat gtcacactgg atccttggcc tccagggtcc 300   

attaaggtga gaataagatc tctgggctgg ctggaactag cctaagactg aaaagcagcc 360   

atg gac atg gcg gat gag cca ctc aat gga agc cac aca tgg cta tcc   408   
Met Asp Met Ala Asp Glu Pro Leu Asn Gly Ser His Thr Trp Leu Ser
  1               5                  10                  15    

att cca ttt gac ctc aat ggc tct gtg gtg tca acc aac acc tca aac   456   
Ile Pro Phe Asp Leu Asn Gly Ser Val Val Ser Thr Asn Thr Ser Asn
             20                  25                  30        

cag aca gag ccg tac tat gac ctg aca agc aat gca gtc ctc aca ttc   504   
Gln Thr Glu Pro Tyr Tyr Asp Leu Thr Ser Asn Ala Val Leu Thr Phe
         35                  40                  45            

atc tat ttt gtg gtc tgc atc att ggg ttg tgt ggc aac aca ctt gtc   552   
Ile Tyr Phe Val Val Cys Ile Ile Gly Leu Cys Gly Asn Thr Leu Val
     50                  55                  60                

att tat gtc atc ctc cgc tat gcc aag atg aag acc atc acc aac att   600   
Ile Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ile Thr Asn Ile
 65                  70                  75                  80

tac atc ctc aac ctg gcc atc gca gat gag ctc ttc atg ctg ggt ctg   648   
Tyr Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Phe Met Leu Gly Leu
                 85                  90                  95    

cct ttc ttg gct atg cag gtg gct ctg gtc cac tgg ccc ttt ggc aag   696   
Pro Phe Leu Ala Met Gln Val Ala Leu Val His Trp Pro Phe Gly Lys
            100                 105                 110        

gcc att tgc cgg gtg gtc atg act gtg gat ggc atc aat cag ttc acc   744   
Ala Ile Cys Arg Val Val Met Thr Val Asp Gly Ile Asn Gln Phe Thr
        115                 120                 125            

agc atc ttc tgc ctg aca gtc atg agc atc gac cga tac ctg gct gtg   792   
Ser Ile Phe Cys Leu Thr Val Met Ser Ile Asp Arg Tyr Leu Ala Val
    130                 135                 140                

gtc cac ccc atc aag tcg gcc aag tgg agg aga ccc cgg acg gcc aag   840   
Val His Pro Ile Lys Ser Ala Lys Trp Arg Arg Pro Arg Thr Ala Lys
145                 150                 155                 160

atg atc acc atg gct gtg tgg gga gtc tct ctg ctg gtc atc ttg ccc   888   
Met Ile Thr Met Ala Val Trp Gly Val Ser Leu Leu Val Ile Leu Pro
                165                 170                 175    

atc atg ata tat gct ggg ctc cgg agc aac cag tgg ggg aga agc agc   936   
Ile Met Ile Tyr Ala Gly Leu Arg Ser Asn Gln Trp Gly Arg Ser Ser
            180                 185                 190        

tgc acc atc aac tgg cca ggt gaa tct ggg gct tgg tac aca ggg ttc   984   
Cys Thr Ile Asn Trp Pro Gly Glu Ser Gly Ala Trp Tyr Thr Gly Phe
        195                 200                 205            

atc atc tac act ttc att ctg ggg ttc ctg gta ccc ctc acc atc atc   1032  
Ile Ile Tyr Thr Phe Ile Leu Gly Phe Leu Val Pro Leu Thr Ile Ile
    210                 215                 220                

tgt ctt tgc tac ctg ttc att atc atc aag gtg aag tcc tct gga atc   1080  
Cys Leu Cys Tyr Leu Phe Ile Ile Ile Lys Val Lys Ser Ser Gly Ile
225                 230                 235                 240

cga gtg ggc tcc tct aag agg aag aag tct gag aag aag gtc acc cga   1128  
Arg Val Gly Ser Ser Lys Arg Lys Lys Ser Glu Lys Lys Val Thr Arg
                245                 250                 255    

atg gtg tcc atc gtg gtg gct gtc ttc atc ttc tgc tgg ctt ccc ttc   1176  
Met Val Ser Ile Val Val Ala Val Phe Ile Phe Cys Trp Leu Pro Phe
            260                 265                 270        

tac ata ttc aac gtt tct tcc gtc tcc atg gcc atc agc ccc acc cca   1224  
Tyr Ile Phe Asn Val Ser Ser Val Ser Met Ala Ile Ser Pro Thr Pro
        275                 280                 285            

gcc ctt aaa ggc atg ttt gac ttt gtg gtg gtc ctc acc tat gct aac   1272  
Ala Leu Lys Gly Met Phe Asp Phe Val Val Val Leu Thr Tyr Ala Asn
    290                 295                 300                

agc tgt gcc aac cct atc cta tat gcc ttc ttg tct gac aac ttc aag   1320  
Ser Cys Ala Asn Pro Ile Leu Tyr Ala Phe Leu Ser Asp Asn Phe Lys
305                 310                 315                 320

aag agc ttc cag aat gtc ctc tgc ttg gtc aag gtg agc ggc aca gat   1368  
Lys Ser Phe Gln Asn Val Leu Cys Leu Val Lys Val Ser Gly Thr Asp
                325                 330                 335    

gat ggg gag cgg agt gac agt aag cag gac aaa tcc cgg ctg aat gag   1416  
Asp Gly Glu Arg Ser Asp Ser Lys Gln Asp Lys Ser Arg Leu Asn Glu
            340                 345                 350        

acc acg gag acc cag agg acc ctc ctc aat gga gac ctc caa acc agt   1464  
Thr Thr Glu Thr Gln Arg Thr Leu Leu Asn Gly Asp Leu Gln Thr Ser
        355                 360                 365            

atc tga actgcttggg gggtgggaaa gaaccaagcc atgctctgtc tactggcaat    1520  
Ile                                                           
    370                                                       

gggctcccta cccacactgg cttcctgcct cccacccctc acacctggct tctagaatag 1580  

aggattgctc agcatgagtc cagttcagag aacggtgttt gagtcagctt gtctgattga 1640  

atgataatgt gctaaattga ttacctcccc cttaaagcga acactgaaat gcaggtagac 1700  

aattcaaagt ctggagaaga gggatcatgc ctggatatga tctttagaaa caacaaaaaa 1760  

aaaaaaaaa                                                         1769  


<210> 6
<211> 369        
<212> PRT
<213> Homo sapiens

<400> 6
Met Asp Met Ala Asp Glu Pro Leu Asn Gly Ser His Thr Trp Leu Ser  
  1               5                  10                  15      
Ile Pro Phe Asp Leu Asn Gly Ser Val Val Ser Thr Asn Thr Ser Asn  
             20                  25                  30          
Gln Thr Glu Pro Tyr Tyr Asp Leu Thr Ser Asn Ala Val Leu Thr Phe  
         35                  40                  45              
Ile Tyr Phe Val Val Cys Ile Ile Gly Leu Cys Gly Asn Thr Leu Val  
     50                  55                  60                  
Ile Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ile Thr Asn Ile  
 65                  70                  75                  80  
Tyr Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Phe Met Leu Gly Leu  
                 85                  90                  95      
Pro Phe Leu Ala Met Gln Val Ala Leu Val His Trp Pro Phe Gly Lys  
            100                 105                 110          
Ala Ile Cys Arg Val Val Met Thr Val Asp Gly Ile Asn Gln Phe Thr  
        115                 120                 125              
Ser Ile Phe Cys Leu Thr Val Met Ser Ile Asp Arg Tyr Leu Ala Val  
    130                 135                 140                  
Val His Pro Ile Lys Ser Ala Lys Trp Arg Arg Pro Arg Thr Ala Lys  
145                 150                 155                 160  
Met Ile Thr Met Ala Val Trp Gly Val Ser Leu Leu Val Ile Leu Pro  
                165                 170                 175      
Ile Met Ile Tyr Ala Gly Leu Arg Ser Asn Gln Trp Gly Arg Ser Ser  
            180                 185                 190          
Cys Thr Ile Asn Trp Pro Gly Glu Ser Gly Ala Trp Tyr Thr Gly Phe  
        195                 200                 205              
Ile Ile Tyr Thr Phe Ile Leu Gly Phe Leu Val Pro Leu Thr Ile Ile  
    210                 215                 220                  
Cys Leu Cys Tyr Leu Phe Ile Ile Ile Lys Val Lys Ser Ser Gly Ile  
225                 230                 235                 240  
Arg Val Gly Ser Ser Lys Arg Lys Lys Ser Glu Lys Lys Val Thr Arg  
                245                 250                 255      
Met Val Ser Ile Val Val Ala Val Phe Ile Phe Cys Trp Leu Pro Phe  
            260                 265                 270          
Tyr Ile Phe Asn Val Ser Ser Val Ser Met Ala Ile Ser Pro Thr Pro  
        275                 280                 285              
Ala Leu Lys Gly Met Phe Asp Phe Val Val Val Leu Thr Tyr Ala Asn  
    290                 295                 300                  
Ser Cys Ala Asn Pro Ile Leu Tyr Ala Phe Leu Ser Asp Asn Phe Lys  
305                 310                 315                 320  
Lys Ser Phe Gln Asn Val Leu Cys Leu Val Lys Val Ser Gly Thr Asp  
                325                 330                 335      
Asp Gly Glu Arg Ser Asp Ser Lys Gln Asp Lys Ser Arg Leu Asn Glu  
            340                 345                 350          
Thr Thr Glu Thr Gln Arg Thr Leu Leu Asn Gly Asp Leu Gln Thr Ser  
        355                 360                 365              
Ile                                                              



<210> 7
<211> 1110
<212> DNA
<213> Mus musculus

<220> 
<221> CDS
<222> (1)..(1110)

<400> 7
atg gag atg agc tct gag cag ttg aat ggg agc caa gta tgg gtg tcc   48    
Met Glu Met Ser Ser Glu Gln Leu Asn Gly Ser Gln Val Trp Val Ser
  1               5                  10                  15    

tct cca ttt gac ctc aac ggc tca ctg ggg cca agc aat ggc tcc aac   96    
Ser Pro Phe Asp Leu Asn Gly Ser Leu Gly Pro Ser Asn Gly Ser Asn
             20                  25                  30        

cag acc gag cca tac tac gac atg aca agc aac gcc gtc ctc acg ttc   144   
Gln Thr Glu Pro Tyr Tyr Asp Met Thr Ser Asn Ala Val Leu Thr Phe
         35                  40                  45            

atc tac ttc gtg gtg tgt gtt gtc ggg ctg tgc ggc aac acg ctg gtc   192   
Ile Tyr Phe Val Val Cys Val Val Gly Leu Cys Gly Asn Thr Leu Val
     50                  55                  60                

att tat gtc atc ctc cgc tat gcc aag atg aag acc atc acc aac atc   240   
Ile Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ile Thr Asn Ile
 65                  70                  75                  80

tac atc ctt aac ctg gcc att gca gat gaa ctc ttc atg cta ggg ctg   288   
Tyr Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Phe Met Leu Gly Leu
                 85                  90                  95    

ccc ttc ttg gcc atg cag gtg gcg cta gtc cac tgg cct ttt ggc aag   336   
Pro Phe Leu Ala Met Gln Val Ala Leu Val His Trp Pro Phe Gly Lys
            100                 105                 110        

gcc atc tgc cgg gtg gtc atg act gta gat ggc atc aat cag ttc acc   384   
Ala Ile Cys Arg Val Val Met Thr Val Asp Gly Ile Asn Gln Phe Thr
        115                 120                 125            

agt atc ttc tgc ttg acg gtc atg agc atc gac cgc tac ctg gcc gtg   432   
Ser Ile Phe Cys Leu Thr Val Met Ser Ile Asp Arg Tyr Leu Ala Val
    130                 135                 140                

gtg cac ccc att aag tca gcc aaa tgg agg cga ccc cgg aca gcc aag   480   
Val His Pro Ile Lys Ser Ala Lys Trp Arg Arg Pro Arg Thr Ala Lys
145                 150                 155                 160

atg atc aat gta gct gtg tgg tgt gtg tct ctg ctc gtc att ttg ccc   528   
Met Ile Asn Val Ala Val Trp Cys Val Ser Leu Leu Val Ile Leu Pro
                165                 170                 175    

atc atg ata tac gcc ggc ctc cgg agc aac cag tgg ggc agg agc agc   576   
Ile Met Ile Tyr Ala Gly Leu Arg Ser Asn Gln Trp Gly Arg Ser Ser
            180                 185                 190        

tgt acc atc aac tgg cca ggc gaa tcc ggg gcg tgg tac aca ggt ttc   624   
Cys Thr Ile Asn Trp Pro Gly Glu Ser Gly Ala Trp Tyr Thr Gly Phe
        195                 200                 205            

att atc tac gcc ttc atc ctg ggg ttc ctg gta ccc ctt acc atc att   672   
Ile Ile Tyr Ala Phe Ile Leu Gly Phe Leu Val Pro Leu Thr Ile Ile
    210                 215                 220                

tgt ctc tgc tac ctg ttc atc atc atc aag gtg aag tcc tct gga atc   720   
Cys Leu Cys Tyr Leu Phe Ile Ile Ile Lys Val Lys Ser Ser Gly Ile
225                 230                 235                 240

cga gtg gga tca tcc aag agg aaa aag tca gag aaa aag gtg acc cgc   768   
Arg Val Gly Ser Ser Lys Arg Lys Lys Ser Glu Lys Lys Val Thr Arg
                245                 250                 255    

atg gtg tcc atc gta gtg gct gtc ttc atc ttc tgc tgg ctc ccc ttc   816   
Met Val Ser Ile Val Val Ala Val Phe Ile Phe Cys Trp Leu Pro Phe
            260                 265                 270        

tac atc ttc aac gtc tct tcc gtg tct gtg gcc atc agt ccc acc cca   864   
Tyr Ile Phe Asn Val Ser Ser Val Ser Val Ala Ile Ser Pro Thr Pro
        275                 280                 285            

gcc ctg aaa ggc atg ttt gac ttt gtg gtg atc ctc acc tat gcc aac   912   
Ala Leu Lys Gly Met Phe Asp Phe Val Val Ile Leu Thr Tyr Ala Asn
    290                 295                 300                

agc tgc gcc aac ccc atc ctg tac gcc ttc ttg tct gac aac ttc aag   960   
Ser Cys Ala Asn Pro Ile Leu Tyr Ala Phe Leu Ser Asp Asn Phe Lys
305                 310                 315                 320

aag agc ttc cag aat gtt ctt tgc ttg gtc aag gtg agt ggt acg gag   1008  
Lys Ser Phe Gln Asn Val Leu Cys Leu Val Lys Val Ser Gly Thr Glu
                325                 330                 335    

gat ggg gag agg agc gac agt aag cag gac aaa tcc cgg ctg aat gag   1056  
Asp Gly Glu Arg Ser Asp Ser Lys Gln Asp Lys Ser Arg Leu Asn Glu
            340                 345                 350        

acc acg gag acc cag agg acc ctc ctc aat gga gac ctc caa acc agt   1104  
Thr Thr Glu Thr Gln Arg Thr Leu Leu Asn Gly Asp Leu Gln Thr Ser
        355                 360                 365            

atc tga                                                           1110  
Ile    
    370


<210> 8
<211> 369        
<212> PRT
<213> Mus musculus

<400> 8
Met Glu Met Ser Ser Glu Gln Leu Asn Gly Ser Gln Val Trp Val Ser  
  1               5                  10                  15      
Ser Pro Phe Asp Leu Asn Gly Ser Leu Gly Pro Ser Asn Gly Ser Asn  
             20                  25                  30          
Gln Thr Glu Pro Tyr Tyr Asp Met Thr Ser Asn Ala Val Leu Thr Phe  
         35                  40                  45              
Ile Tyr Phe Val Val Cys Val Val Gly Leu Cys Gly Asn Thr Leu Val  
     50                  55                  60                  
Ile Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ile Thr Asn Ile  
 65                  70                  75                  80  
Tyr Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Phe Met Leu Gly Leu  
                 85                  90                  95      
Pro Phe Leu Ala Met Gln Val Ala Leu Val His Trp Pro Phe Gly Lys  
            100                 105                 110          
Ala Ile Cys Arg Val Val Met Thr Val Asp Gly Ile Asn Gln Phe Thr  
        115                 120                 125              
Ser Ile Phe Cys Leu Thr Val Met Ser Ile Asp Arg Tyr Leu Ala Val  
    130                 135                 140                  
Val His Pro Ile Lys Ser Ala Lys Trp Arg Arg Pro Arg Thr Ala Lys  
145                 150                 155                 160  
Met Ile Asn Val Ala Val Trp Cys Val Ser Leu Leu Val Ile Leu Pro  
                165                 170                 175      
Ile Met Ile Tyr Ala Gly Leu Arg Ser Asn Gln Trp Gly Arg Ser Ser  
            180                 185                 190          
Cys Thr Ile Asn Trp Pro Gly Glu Ser Gly Ala Trp Tyr Thr Gly Phe  
        195                 200                 205              
Ile Ile Tyr Ala Phe Ile Leu Gly Phe Leu Val Pro Leu Thr Ile Ile  
    210                 215                 220                  
Cys Leu Cys Tyr Leu Phe Ile Ile Ile Lys Val Lys Ser Ser Gly Ile  
225                 230                 235                 240  
Arg Val Gly Ser Ser Lys Arg Lys Lys Ser Glu Lys Lys Val Thr Arg  
                245                 250                 255      
Met Val Ser Ile Val Val Ala Val Phe Ile Phe Cys Trp Leu Pro Phe  
            260                 265                 270          
Tyr Ile Phe Asn Val Ser Ser Val Ser Val Ala Ile Ser Pro Thr Pro  
        275                 280                 285              
Ala Leu Lys Gly Met Phe Asp Phe Val Val Ile Leu Thr Tyr Ala Asn  
    290                 295                 300                  
Ser Cys Ala Asn Pro Ile Leu Tyr Ala Phe Leu Ser Asp Asn Phe Lys  
305                 310                 315                 320  
Lys Ser Phe Gln Asn Val Leu Cys Leu Val Lys Val Ser Gly Thr Glu  
                325                 330                 335      
Asp Gly Glu Arg Ser Asp Ser Lys Gln Asp Lys Ser Arg Leu Asn Glu  
            340                 345                 350          
Thr Thr Glu Thr Gln Arg Thr Leu Leu Asn Gly Asp Leu Gln Thr Ser  
        355                 360                 365              
Ile                                                              



<210> 9
<211> 4730
<212> DNA
<213> Mus musculus

<220> 
<221> CDS
<222> (2091)..(3200)

<400> 9
ggtaccagcc accagcttcg acccactgag catcagctgg gacatggtga aaatcacaga 60    

agacttgggg ccagctggtt ctcgtccaag tgctcactcc accaagcact ttaactctct 120   

aagcctcagt ttccactgag ggaggacgga atcctcacct cctggggaca atggggacaa 180   

tgggtgtgac tagactccat ccggtttttt attttattta tttatttatt tatttatctg 240   

tttatttatt tatttatttc gtgtatgtga gtacaccatt gttctcttca tacataccag 300   

aagaggcacc ggatcccatt acaaatggtt gtgagccacc atgtggttgc tgggaattga 360   

actcaggacc tctaaaagag tagtcagagc tcttaaccat ctctccagcc caagaaacac 420   

tttaattctt gatagataaa taaataaata aataaataaa taaaagcatc tttgacattc 480   

atgaaaagcc tacatccctc ccctagttcc ctgggttttt tttttttttt tttttttttg 540   

tcctaagtca gagaactgca ggcaaaaggt ctttaggaga gagccttccc aagcagagat 600   

ggagtggaga atggagaaca ttgatgttac aaaatcagaa ccaggaggag gagaagagaa 660   

agagggggaa gagaagaggg aggaagagga gagggcctaa agcatcatta aaaaaaaaaa 720   

aagccagact cttactttta atattgaaga ctataacttg attcactgtg taggcaggct 780   

tcaataaatt agagataatg agacagtaga cggggggagg taacgtttat gaggctctga 840   

ttataagcct gcacaatgct aggatttgca cacactttct cttgtttaac cttcatgaca 900   

cccctgtgtt gacaaaggag agttacagca gttaagggct gggcatgggg tcacgtgggg 960   

ctcaactctg gagccaaagt ttgttctccc tttaacttct tgagttttcc caccacgggg 1020  

gcgggggtat ctctgatggt ggcagacatc aagccagcat agagttgttc ttggggtccc 1080  

caaatgctgg tgtcagactc ctccagggac aggggttgaa accctccaag atctgccttt 1140  

ttccagtctg gatcggtcaa ttccttaggg gtcaaagtct atgtgtttga agccatagcc 1200  

gtctgccaca tgtgtgtcat ctaggatgat ggtttaactc aaacccttcc cccaccattg 1260  

aaaaaaagac ctcaaaaagt cttcaggctg acaggtgggc tggcagctag acagaaaaaa 1320  

aaaaaaagaa aacttgcttt tcaattgaaa aatgcataga aggggaacaa gggattggta 1380  

gctcactgtg actccaaaca gcagaggccc aggcatggga gtgctacgca tgaaagtcag 1440  

ctaaggctac atagtgagct ccaggctagc tcagctcaag gaagaaggag gaggggaaag 1500  

ggaggaggga gagaggggag gaggaggagg aagaagagag gaggaagaag aaggaagaga 1560  

gggagtgatg tgggagggaa agaaaagaag gaaggaggga ggaagagggg gagatggctc 1620  

cgtcaataaa gcacctgact tgcaagcaag aagacctgag ttcaacctcc agaaccacat 1680  

aaaactgccg gtatatttga tacatatctg taatcacagc cgtgggggag gcagacacag 1740  

gtggatctct gcagctcact gaacagctag cccaagctac atggtgaaac atcatgactc 1800  

aaaaaagggt gaggctatca aacctatgta aacacacaca cacaaacaca cacatacacc 1860  

atgcagcagc acacatgaat acatgaaaaa aaaagaggaa ttgggggggc atggaacgtg 1920  

aaactaagaa gatgaacaag aaacagaggg agcctaagta gcctgggact gacggctact 1980  

ttttctgctt cttttcccag atgtcacagt agactcttgg cccccagagc cctgtgaggc 2040  

gagaggaaga tctctaggca gcttggttct agacggagtg gaaagcagcc atg gag    2096  
                                                       Met Glu
                                                         1    

atg agc tct gag cag ttg aat ggg agc caa gta tgg gtg tcc tct cca   2144  
Met Ser Ser Glu Gln Leu Asn Gly Ser Gln Val Trp Val Ser Ser Pro
          5                  10                  15            

ttt gac ctc aac ggc tca ctg ggg cca agc aat ggc tcc aac cag acc   2192  
Phe Asp Leu Asn Gly Ser Leu Gly Pro Ser Asn Gly Ser Asn Gln Thr
     20                  25                  30                

gag cca tac tac gac atg aca agc aac gcc gtc ctc acg ttc atc tac   2240  
Glu Pro Tyr Tyr Asp Met Thr Ser Asn Ala Val Leu Thr Phe Ile Tyr
 35                  40                  45                  50

ttc gtg gtg tgt gtt gtc ggg ctg tgc ggc aac acg ctg gtc att tat   2288  
Phe Val Val Cys Val Val Gly Leu Cys Gly Asn Thr Leu Val Ile Tyr
                 55                  60                  65    

gtc atc ctc cgc tat gcc aag atg aag acc atc acc aac atc tac atc   2336  
Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ile Thr Asn Ile Tyr Ile
             70                  75                  80        

ctt aac ctg gcc att gca gat gaa ctc ttc atg cta ggg ctg ccc ttc   2384  
Leu Asn Leu Ala Ile Ala Asp Glu Leu Phe Met Leu Gly Leu Pro Phe
         85                  90                  95            

ttg gcc atg cag gtg gcg cta gtc cac tgg cct ttt ggc aag gcc atc   2432  
Leu Ala Met Gln Val Ala Leu Val His Trp Pro Phe Gly Lys Ala Ile
    100                 105                 110                

tgc cgg gtg gtc atg act gta gat ggc atc aat cag ttc acc agt atc   2480  
Cys Arg Val Val Met Thr Val Asp Gly Ile Asn Gln Phe Thr Ser Ile
115                 120                 125                 130

ttc tgc ttg acg gtc atg agc atc gac cgc tac ctg gcc gtg gtg cac   2528  
Phe Cys Leu Thr Val Met Ser Ile Asp Arg Tyr Leu Ala Val Val His
                135                 140                 145    

ccc att aag tca gcc aaa tgg agg cga ccc cgg aca gcc aag atg atc   2576  
Pro Ile Lys Ser Ala Lys Trp Arg Arg Pro Arg Thr Ala Lys Met Ile
            150                 155                 160        

aat gta gct gtg tgg tgt gtg tct ctg ctc gtc att ttg ccc atc atg   2624  
Asn Val Ala Val Trp Cys Val Ser Leu Leu Val Ile Leu Pro Ile Met
        165                 170                 175            

ata tac gcc ggc ctc cgg agc aac cag tgg ggc agg agc agc tgt acc   2672  
Ile Tyr Ala Gly Leu Arg Ser Asn Gln Trp Gly Arg Ser Ser Cys Thr
    180                 185                 190                

atc aac tgg cca ggc gaa tcc ggg gcg tgg tac aca ggt ttc att atc   2720  
Ile Asn Trp Pro Gly Glu Ser Gly Ala Trp Tyr Thr Gly Phe Ile Ile
195                 200                 205                 210

tac gcc ttc atc ctg ggg ttc ctg gta ccc ctt acc atc att tgt ctc   2768  
Tyr Ala Phe Ile Leu Gly Phe Leu Val Pro Leu Thr Ile Ile Cys Leu
                215                 220                 225    

tgc tac ctg ttc atc atc atc aag gtg aag tcc tct gga atc cga gtg   2816  
Cys Tyr Leu Phe Ile Ile Ile Lys Val Lys Ser Ser Gly Ile Arg Val
            230                 235                 240        

gga tca tcc aag agg aaa aag tca gag aaa aag gtg acc cgc atg gtg   2864  
Gly Ser Ser Lys Arg Lys Lys Ser Glu Lys Lys Val Thr Arg Met Val
        245                 250                 255            

tcc atc gta gtg gct gtc ttc atc ttc tgc tgg ctc ccc ttc tac atc   2912  
Ser Ile Val Val Ala Val Phe Ile Phe Cys Trp Leu Pro Phe Tyr Ile
    260                 265                 270                

ttc aac gtc tct tcc gtg tct gtg gcc atc agt ccc acc cca gcc ctg   2960  
Phe Asn Val Ser Ser Val Ser Val Ala Ile Ser Pro Thr Pro Ala Leu
275                 280                 285                 290

aaa ggc atg ttt gac ttt gtg gtg atc ctc acc tat gcc aac agc tgc   3008  
Lys Gly Met Phe Asp Phe Val Val Ile Leu Thr Tyr Ala Asn Ser Cys
                295                 300                 305    

gcc aac ccc atc ctg tac gcc ttc ttg tct gac aac ttc aag aag agc   3056  
Ala Asn Pro Ile Leu Tyr Ala Phe Leu Ser Asp Asn Phe Lys Lys Ser
            310                 315                 320        

ttc cag aat gtt ctt tgc ttg gtc aag gtg agt ggt acg gag gat ggg   3104  
Phe Gln Asn Val Leu Cys Leu Val Lys Val Ser Gly Thr Glu Asp Gly
        325                 330                 335            

gag agg agc gac agt aag cag gac aaa tcc cgg ctg aat gag acc acg   3152  
Glu Arg Ser Asp Ser Lys Gln Asp Lys Ser Arg Leu Asn Glu Thr Thr
    340                 345                 350                

gag acc cag agg acc ctc ctc aat gga gac ctc caa acc agt atc tga   3200  
Glu Thr Gln Arg Thr Leu Leu Asn Gly Asp Leu Gln Thr Ser Ile    
355                 360                 365                 370

acaacccagg aacgcaacat gcacacacac tagccaagcc ctgactcctg tcagtgtgtc 3260  

tcccattccc tggcttcccg cctcccctat ccatcacacc cggcttctag aacagagctg 3320  

tgttctacac gcgccccgtt cagagaacag gatttgagtc tggcttgtcc gaaagtatac 3380  

ccctctggtc acgtctcccc taaagtgaac gttttcgtgc aggcagacaa ttcacaatcc 3440  

ggagcggaag acatcattgc ctgggtgtga cctggtggaa aacagctgcc cggcagaaac 3500  

cggaaaaacc aaaactaaat caaagtcctg tgtgtatgtg tgctaacacg ttacgtaaat 3560  

cttgtgatct gatatttaca tttgtatatt ctcccctccc cggtcacaca aacatgtccc 3620  

gtgtttgtaa gcccaagtag ctagttcgtg tgcgtctagt ataggtggac agttaccaca 3680  

acgctgaacc tgaagaaaag gactcgccac gtcacagtca gtccaatcta agcttccagc 3740  

atctgtcttg catgggccat ccccagacac tggaggagca tgagcagtat gtatgttcat 3800  

aggataatat aataatatgt tcgtagaata atataataat atgtttttgt aaaaaaaaaa 3860  

ttgaaagtaa ggtggttttg tattctttat cctagagggc ccctgtcata tatatggtcc 3920  

tagcctcgca ggcgctgcac ctgcgccagg aagggtattt catcaatttc aaacatgtga 3980  

agttggagta agaagagaca gtgagaatat tctgtgagag tcagaatgta aactcgggtt 4040  

tgaatgtaac tctcagatac gatcagttat tcatttaccc aaaaggactt taagggttgt 4100  

ggccatagag catgccattt atcaggacga agcctgcttt gagatcagat tatagatttc 4160  

tctcctcaaa ttcctttcgc ttcggaaacc attggggaag ggaggggtca ggagcctgag 4220  

aggcaaaaac cagactatga ttcccatggg gaaacaaatt ttctcctcaa cacatacctg 4280  

tgcctgtgtg agttcataca cacacacaca cacacacaca cacacacaca cacacacaca 4340  

caaataataa tgaaaagaaa aaagaagtag aattatgcct ttaagggcaa ccatgaagtt 4400  

gtcttgtttt taatgccagg taggatttct taatgaaaga aaacagaact gtaattccac 4460  

aactccttaa aggtgctttg ggttggcttg tccttggttg gtttgttctt ggggacaggt 4520  

ggttgttgtt tcttcctgtc ttatgtgtat gcagtgggta tgtgtgttta tgcctctgtg 4580  

tgtgtgtgtg tgcgctcgtg tacttatgtg tgtgcaggct ggaggctgat actgctacct 4640  

ccctacatca ttgactaact ttactgagac agggtctctt gctgaacgtg aagccttctg 4700  

gtcaagtgag ccggcttgcc tcgaggatcc                                  4730  


<210> 10
<211> 369        
<212> PRT
<213> Mus musculus

<400> 10
Met Glu Met Ser Ser Glu Gln Leu Asn Gly Ser Gln Val Trp Val Ser  
  1               5                  10                  15      
Ser Pro Phe Asp Leu Asn Gly Ser Leu Gly Pro Ser Asn Gly Ser Asn  
             20                  25                  30          
Gln Thr Glu Pro Tyr Tyr Asp Met Thr Ser Asn Ala Val Leu Thr Phe  
         35                  40                  45              
Ile Tyr Phe Val Val Cys Val Val Gly Leu Cys Gly Asn Thr Leu Val  
     50                  55                  60                  
Ile Tyr Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ile Thr Asn Ile  
 65                  70                  75                  80  
Tyr Ile Leu Asn Leu Ala Ile Ala Asp Glu Leu Phe Met Leu Gly Leu  
                 85                  90                  95      
Pro Phe Leu Ala Met Gln Val Ala Leu Val His Trp Pro Phe Gly Lys  
            100                 105                 110          
Ala Ile Cys Arg Val Val Met Thr Val Asp Gly Ile Asn Gln Phe Thr  
        115                 120                 125              
Ser Ile Phe Cys Leu Thr Val Met Ser Ile Asp Arg Tyr Leu Ala Val  
    130                 135                 140                  
Val His Pro Ile Lys Ser Ala Lys Trp Arg Arg Pro Arg Thr Ala Lys  
145                 150                 155                 160  
Met Ile Asn Val Ala Val Trp Cys Val Ser Leu Leu Val Ile Leu Pro  
                165                 170                 175      
Ile Met Ile Tyr Ala Gly Leu Arg Ser Asn Gln Trp Gly Arg Ser Ser  
            180                 185                 190          
Cys Thr Ile Asn Trp Pro Gly Glu Ser Gly Ala Trp Tyr Thr Gly Phe  
        195                 200                 205              
Ile Ile Tyr Ala Phe Ile Leu Gly Phe Leu Val Pro Leu Thr Ile Ile  
    210                 215                 220                  
Cys Leu Cys Tyr Leu Phe Ile Ile Ile Lys Val Lys Ser Ser Gly Ile  
225                 230                 235                 240  
Arg Val Gly Ser Ser Lys Arg Lys Lys Ser Glu Lys Lys Val Thr Arg  
                245                 250                 255      
Met Val Ser Ile Val Val Ala Val Phe Ile Phe Cys Trp Leu Pro Phe  
            260                 265                 270          
Tyr Ile Phe Asn Val Ser Ser Val Ser Val Ala Ile Ser Pro Thr Pro  
        275                 280                 285              
Ala Leu Lys Gly Met Phe Asp Phe Val Val Ile Leu Thr Tyr Ala Asn  
    290                 295                 300                  
Ser Cys Ala Asn Pro Ile Leu Tyr Ala Phe Leu Ser Asp Asn Phe Lys  
305                 310                 315                 320  
Lys Ser Phe Gln Asn Val Leu Cys Leu Val Lys Val Ser Gly Thr Glu  
                325                 330                 335      
Asp Gly Glu Arg Ser Asp Ser Lys Gln Asp Lys Ser Arg Leu Asn Glu  
            340                 345                 350          
Thr Thr Glu Thr Gln Arg Thr Leu Leu Asn Gly Asp Leu Gln Thr Ser  
        355                 360                 365              
Ile                                                              



<210> 11
<211> 1266
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (10)..(1266)

<400> 11
gcccttacc atg gac atg ctt cat cca tca tcg gtg tcc acg acc tca gaa 51    
          Met Asp Met Leu His Pro Ser Ser Val Ser Thr Thr Ser Glu
            1               5                  10                

cct gag aat gcc tcc tcg gcc tgg ccc cca gat gcc acc ctg ggc aac   99    
Pro Glu Asn Ala Ser Ser Ala Trp Pro Pro Asp Ala Thr Leu Gly Asn
 15                  20                  25                  30

gtg tcg gca ggc cca agc ccg gca ggg ctg gcc gtc agt ggc gtt ctg   147   
Val Ser Ala Gly Pro Ser Pro Ala Gly Leu Ala Val Ser Gly Val Leu
                 35                  40                  45    

atc ccc ctg gtc tac ctg gtg gtg tgc gtg gtg ggc ctg ctg ggt aac   195   
Ile Pro Leu Val Tyr Leu Val Val Cys Val Val Gly Leu Leu Gly Asn
             50                  55                  60        

tcg ctg gtc atc tat gtg gtc ctg cgg cac acg gcc agc cct tca gtc   243   
Ser Leu Val Ile Tyr Val Val Leu Arg His Thr Ala Ser Pro Ser Val
         65                  70                  75            

acc aac gtc tac atc ctc aac ctg gcg ctg gcc gac gag ctc ttc atg   291   
Thr Asn Val Tyr Ile Leu Asn Leu Ala Leu Ala Asp Glu Leu Phe Met
     80                  85                  90                

ctg ggg ctg ccc ttc ctg gcc gcc cag aac gcc ctg tcc tac tgg ccc   339   
Leu Gly Leu Pro Phe Leu Ala Ala Gln Asn Ala Leu Ser Tyr Trp Pro
 95                 100                 105                 110

ttc ggc tcc ctc atg tgc cgc ctg gtc atg gcg gtg gat ggc atc aac   387   
Phe Gly Ser Leu Met Cys Arg Leu Val Met Ala Val Asp Gly Ile Asn
                115                 120                 125    

cag ttc acc agc ata ttc tgc ctg act gtc atg agc gtg gac cgc tac   435   
Gln Phe Thr Ser Ile Phe Cys Leu Thr Val Met Ser Val Asp Arg Tyr
            130                 135                 140        

ctg gcc gtg gta cat ccc acc cgc tca gcc cgc tgg cgc aca gct ccg   483   
Leu Ala Val Val His Pro Thr Arg Ser Ala Arg Trp Arg Thr Ala Pro
        145                 150                 155            

gtg gcc cgc acg gtc agc gcg gct gtg tgg gtg gcc tca gcc gtg gtg   531   
Val Ala Arg Thr Val Ser Ala Ala Val Trp Val Ala Ser Ala Val Val
    160                 165                 170                

gtg ctg ccc gtg gtg gtc ttc tcg gga gtg ccc cgc ggc atg agc acc   579   
Val Leu Pro Val Val Val Phe Ser Gly Val Pro Arg Gly Met Ser Thr
175                 180                 185                 190

tgc cac atg cag tgg ccc gag ccg gcg gcg gcc tgg cga gcc ggc ttc   627   
Cys His Met Gln Trp Pro Glu Pro Ala Ala Ala Trp Arg Ala Gly Phe
                195                 200                 205    

atc atc tac acg gcc gca ctg ggc ttc ttc ggg ccg ctg ctg gtc atc   675   
Ile Ile Tyr Thr Ala Ala Leu Gly Phe Phe Gly Pro Leu Leu Val Ile
            210                 215                 220        

tgc ctc tgc tac ctg ctc atc gtg gtg aag gtg cgc tca gct ggg cgc   723   
Cys Leu Cys Tyr Leu Leu Ile Val Val Lys Val Arg Ser Ala Gly Arg
        225                 230                 235            

cgg gtg tgg gca ccc tcg tgc cag cgg cgg cgg cgc tcc gaa cgc agg   771   
Arg Val Trp Ala Pro Ser Cys Gln Arg Arg Arg Arg Ser Glu Arg Arg
    240                 245                 250                

gtc acg cgc atg gtg gtg gcc gtg gtg gca ctc ttc gtg ctc tgc tgg   819   
Val Thr Arg Met Val Val Ala Val Val Ala Leu Phe Val Leu Cys Trp
255                 260                 265                 270

atg ccc ttc tat gtg ctc aac atc gtc aac gtg gtg tgc cca ctg ccc   867   
Met Pro Phe Tyr Val Leu Asn Ile Val Asn Val Val Cys Pro Leu Pro
                275                 280                 285    

gag gag cct gcc ttc ttt ggg ctc tac ttc ctg gtg gtg gcg ctg ccc   915   
Glu Glu Pro Ala Phe Phe Gly Leu Tyr Phe Leu Val Val Ala Leu Pro
            290                 295                 300        

tat gcc aac agc tgt gcc aac ccc atc ctt tat ggc ttc ctc tcc tac   963   
Tyr Ala Asn Ser Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser Tyr
        305                 310                 315            

cgc ttc aag cag ggc ttc cgc agg gtc ctg ctg cgg ccc tcc cgc cgt   1011  
Arg Phe Lys Gln Gly Phe Arg Arg Val Leu Leu Arg Pro Ser Arg Arg
    320                 325                 330                

gtg cgc agc cag gag ccc act gtg ggg ccc ccg gag aag act gag gag   1059  
Val Arg Ser Gln Glu Pro Thr Val Gly Pro Pro Glu Lys Thr Glu Glu
335                 340                 345                 350

gag gat gag gag gag gag gat ggg gag gag agc agg gag ggg ggc aag   1107  
Glu Asp Glu Glu Glu Glu Asp Gly Glu Glu Ser Arg Glu Gly Gly Lys
                355                 360                 365    

ggg aag gag atg aac ggc cgg gtc agc cag atc acg cag cct ggc acc   1155  
Gly Lys Glu Met Asn Gly Arg Val Ser Gln Ile Thr Gln Pro Gly Thr
            370                 375                 380        

agc ggg cag gag cgg ccg ccc agc aga gtg gcc agc aag gag cag cag   1203  
Ser Gly Gln Glu Arg Pro Pro Ser Arg Val Ala Ser Lys Glu Gln Gln
        385                 390                 395            

ctc cta ccc caa gag gct tcc act ggg gag aag tcc agc acg atg cgc   1251  
Leu Leu Pro Gln Glu Ala Ser Thr Gly Glu Lys Ser Ser Thr Met Arg
    400                 405                 410                

atc agc tac ctg tag                                               1266  
Ile Ser Tyr Leu    
415                


<210> 12
<211> 418        
<212> PRT
<213> Homo sapiens

<400> 12
Met Asp Met Leu His Pro Ser Ser Val Ser Thr Thr Ser Glu Pro Glu  
  1               5                  10                  15      
Asn Ala Ser Ser Ala Trp Pro Pro Asp Ala Thr Leu Gly Asn Val Ser  
             20                  25                  30          
Ala Gly Pro Ser Pro Ala Gly Leu Ala Val Ser Gly Val Leu Ile Pro  
         35                  40                  45              
Leu Val Tyr Leu Val Val Cys Val Val Gly Leu Leu Gly Asn Ser Leu  
     50                  55                  60                  
Val Ile Tyr Val Val Leu Arg His Thr Ala Ser Pro Ser Val Thr Asn  
 65                  70                  75                  80  
Val Tyr Ile Leu Asn Leu Ala Leu Ala Asp Glu Leu Phe Met Leu Gly  
                 85                  90                  95      
Leu Pro Phe Leu Ala Ala Gln Asn Ala Leu Ser Tyr Trp Pro Phe Gly  
            100                 105                 110          
Ser Leu Met Cys Arg Leu Val Met Ala Val Asp Gly Ile Asn Gln Phe  
        115                 120                 125              
Thr Ser Ile Phe Cys Leu Thr Val Met Ser Val Asp Arg Tyr Leu Ala  
    130                 135                 140                  
Val Val His Pro Thr Arg Ser Ala Arg Trp Arg Thr Ala Pro Val Ala  
145                 150                 155                 160  
Arg Thr Val Ser Ala Ala Val Trp Val Ala Ser Ala Val Val Val Leu  
                165                 170                 175      
Pro Val Val Val Phe Ser Gly Val Pro Arg Gly Met Ser Thr Cys His  
            180                 185                 190          
Met Gln Trp Pro Glu Pro Ala Ala Ala Trp Arg Ala Gly Phe Ile Ile  
        195                 200                 205              
Tyr Thr Ala Ala Leu Gly Phe Phe Gly Pro Leu Leu Val Ile Cys Leu  
    210                 215                 220                  
Cys Tyr Leu Leu Ile Val Val Lys Val Arg Ser Ala Gly Arg Arg Val  
225                 230                 235                 240  
Trp Ala Pro Ser Cys Gln Arg Arg Arg Arg Ser Glu Arg Arg Val Thr  
                245                 250                 255      
Arg Met Val Val Ala Val Val Ala Leu Phe Val Leu Cys Trp Met Pro  
            260                 265                 270          
Phe Tyr Val Leu Asn Ile Val Asn Val Val Cys Pro Leu Pro Glu Glu  
        275                 280                 285              
Pro Ala Phe Phe Gly Leu Tyr Phe Leu Val Val Ala Leu Pro Tyr Ala  
    290                 295                 300                  
Asn Ser Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser Tyr Arg Phe  
305                 310                 315                 320  
Lys Gln Gly Phe Arg Arg Val Leu Leu Arg Pro Ser Arg Arg Val Arg  
                325                 330                 335      
Ser Gln Glu Pro Thr Val Gly Pro Pro Glu Lys Thr Glu Glu Glu Asp  
            340                 345                 350          
Glu Glu Glu Glu Asp Gly Glu Glu Ser Arg Glu Gly Gly Lys Gly Lys  
        355                 360                 365              
Glu Met Asn Gly Arg Val Ser Gln Ile Thr Gln Pro Gly Thr Ser Gly  
    370                 375                 380                  
Gln Glu Arg Pro Pro Ser Arg Val Ala Ser Lys Glu Gln Gln Leu Leu  
385                 390                 395                 400  
Pro Gln Glu Ala Ser Thr Gly Glu Lys Ser Ser Thr Met Arg Ile Ser  
                405                 410                 415      
Tyr Leu                                                          



<210> 13
<211> 1383
<212> DNA
<213> Mus musculus

<220> 
<221> CDS
<222> (41)..(1327)

<400> 13
gttagggctg gttggctgct gactgatcct catctcagcc atg gcc act gtt acc   55    
                                            Met Ala Thr Val Thr
                                              1               5

tat ccc tca tcc gag cct atg acc ttg gac cct ggg aac aca tcc tcg   103   
Tyr Pro Ser Ser Glu Pro Met Thr Leu Asp Pro Gly Asn Thr Ser Ser
                 10                  15                  20    

acc tgg ccc ctg gat acc acc ctg ggg aac aca tcc gct ggc gct agc   151   
Thr Trp Pro Leu Asp Thr Thr Leu Gly Asn Thr Ser Ala Gly Ala Ser
             25                  30                  35        

ctg aca ggc ctg gct gtc agt ggc atc ttg atc tct ctg gtg tac ctg   199   
Leu Thr Gly Leu Ala Val Ser Gly Ile Leu Ile Ser Leu Val Tyr Leu
         40                  45                  50            

gtg gtg tgc gtg gtg ggt ctg ctg ggc aac tcg ctg gtg atc tac gtg   247   
Val Val Cys Val Val Gly Leu Leu Gly Asn Ser Leu Val Ile Tyr Val
     55                  60                  65                

gtc ctg cgg cac acg tcc agc cca tca gtg acc agt gtc tat atc ctc   295   
Val Leu Arg His Thr Ser Ser Pro Ser Val Thr Ser Val Tyr Ile Leu
 70                  75                  80                  85

aac ctg gct ctg gct gat gag ctc ttc atg cta ggg cta ccc ttc ctg   343   
Asn Leu Ala Leu Ala Asp Glu Leu Phe Met Leu Gly Leu Pro Phe Leu
                 90                  95                 100    

gct gct cag aac gcc ctg tcc tac tgg ccc ttt gga tct ctc atg tgc   391   
Ala Ala Gln Asn Ala Leu Ser Tyr Trp Pro Phe Gly Ser Leu Met Cys
            105                 110                 115        

cgt ctg gtc atg gcc gtg gat ggc atc aac cag ttc acc agc atc ttc   439   
Arg Leu Val Met Ala Val Asp Gly Ile Asn Gln Phe Thr Ser Ile Phe
        120                 125                 130            

tgc ctc acc gtc atg agt gtg gac cgc tat ctg gct gtg gtg cac ccc   487   
Cys Leu Thr Val Met Ser Val Asp Arg Tyr Leu Ala Val Val His Pro
    135                 140                 145                

aca cgc tca gcc cgc tgg cgc acg gca cca gtg gct cgc acg gtc agt   535   
Thr Arg Ser Ala Arg Trp Arg Thr Ala Pro Val Ala Arg Thr Val Ser
150                 155                 160                 165

gca gct gtc tgg gtg gcc tcg gct gtg gtg gtg ctg cct gtg gtt gtg   583   
Ala Ala Val Trp Val Ala Ser Ala Val Val Val Leu Pro Val Val Val
                170                 175                 180    

ttc tca gga gtg ccc cgg ggc atg agc acg tgc cac atg cag tgg cca   631   
Phe Ser Gly Val Pro Arg Gly Met Ser Thr Cys His Met Gln Trp Pro
            185                 190                 195        

gag cca gcg gct gcc tgg cga aca gcc ttc atc atc tac acg gcc gca   679   
Glu Pro Ala Ala Ala Trp Arg Thr Ala Phe Ile Ile Tyr Thr Ala Ala
        200                 205                 210            

ctg ggc ttc ttt ggg ccc ctg ctg gtc atc tgc ttg tgc tac ttg ctc   727   
Leu Gly Phe Phe Gly Pro Leu Leu Val Ile Cys Leu Cys Tyr Leu Leu
    215                 220                 225                

att gtg gta aag gtg cgg tcg acc acc cgg cgg gtg cgg gcg ccc tcg   775   
Ile Val Val Lys Val Arg Ser Thr Thr Arg Arg Val Arg Ala Pro Ser
230                 235                 240                 245

tgt cag tgg gta cag gca ccc gca tgc cag cgg cga cgc cgc tct gag   823   
Cys Gln Trp Val Gln Ala Pro Ala Cys Gln Arg Arg Arg Arg Ser Glu
                250                 255                 260    

cgc agg gtc aca cgc atg gtg gtg gcc gtg gtg gca ctc ttc gtc ctc   871   
Arg Arg Val Thr Arg Met Val Val Ala Val Val Ala Leu Phe Val Leu
            265                 270                 275        

tgc tgg atg cct ttc tat ctg ctc aac atc gtc aat gtg gtg tgc ccg   919   
Cys Trp Met Pro Phe Tyr Leu Leu Asn Ile Val Asn Val Val Cys Pro
        280                 285                 290            

ctg ccg gag gag ccc gcc ttc ttc ggc ctc tac ttc ctg gtg gtg gcg   967   
Leu Pro Glu Glu Pro Ala Phe Phe Gly Leu Tyr Phe Leu Val Val Ala
    295                 300                 305                

ctg ccc tac gcc aac agc tgc gca aac ccc atc ctc tac ggc ttc ctc   1015  
Leu Pro Tyr Ala Asn Ser Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu
310                 315                 320                 325

tcc tac cgc ttc aag cag ggc ttt cgc agg atc ctg cta aga cca tca   1063  
Ser Tyr Arg Phe Lys Gln Gly Phe Arg Arg Ile Leu Leu Arg Pro Ser
                330                 335                 340    

cgt cgc att cgg agc cag gag cca ggg tcg gga cct cca gag aag act   1111  
Arg Arg Ile Arg Ser Gln Glu Pro Gly Ser Gly Pro Pro Glu Lys Thr
            345                 350                 355        

gaa gag gag gag gat gaa gaa gaa gaa gag aga agg gaa gag gag gag   1159  
Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Arg Arg Glu Glu Glu Glu
        360                 365                 370            

cgg agg atg cag aga ggg cag gag atg aac ggg agg ctc agt cag atc   1207  
Arg Arg Met Gln Arg Gly Gln Glu Met Asn Gly Arg Leu Ser Gln Ile
    375                 380                 385                

gca cag gct ggc act agt gga caa cag cca cgg ccc tgc aca ggg act   1255  
Ala Gln Ala Gly Thr Ser Gly Gln Gln Pro Arg Pro Cys Thr Gly Thr
390                 395                 400                 405

gct aag gag cag cag ctt ctg ccc cag gag gcc aca gct ggg gac aag   1303  
Ala Lys Glu Gln Gln Leu Leu Pro Gln Glu Ala Thr Ala Gly Asp Lys
                410                 415                 420    

gcc agc aca ctg agc cat ctg taa ggaccttcaa agaaccagcg tggttcagaa  1357  
Ala Ser Thr Leu Ser His Leu                                     
            425                                                 

aagagcagaa gctgggcttg acctcg                                      1383  


<210> 14
<211> 428        
<212> PRT
<213> Mus musculus

<400> 14
Met Ala Thr Val Thr Tyr Pro Ser Ser Glu Pro Met Thr Leu Asp Pro  
  1               5                  10                  15      
Gly Asn Thr Ser Ser Thr Trp Pro Leu Asp Thr Thr Leu Gly Asn Thr  
             20                  25                  30          
Ser Ala Gly Ala Ser Leu Thr Gly Leu Ala Val Ser Gly Ile Leu Ile  
         35                  40                  45              
Ser Leu Val Tyr Leu Val Val Cys Val Val Gly Leu Leu Gly Asn Ser  
     50                  55                  60                  
Leu Val Ile Tyr Val Val Leu Arg His Thr Ser Ser Pro Ser Val Thr  
 65                  70                  75                  80  
Ser Val Tyr Ile Leu Asn Leu Ala Leu Ala Asp Glu Leu Phe Met Leu  
                 85                  90                  95      
Gly Leu Pro Phe Leu Ala Ala Gln Asn Ala Leu Ser Tyr Trp Pro Phe  
            100                 105                 110          
Gly Ser Leu Met Cys Arg Leu Val Met Ala Val Asp Gly Ile Asn Gln  
        115                 120                 125              
Phe Thr Ser Ile Phe Cys Leu Thr Val Met Ser Val Asp Arg Tyr Leu  
    130                 135                 140                  
Ala Val Val His Pro Thr Arg Ser Ala Arg Trp Arg Thr Ala Pro Val  
145                 150                 155                 160  
Ala Arg Thr Val Ser Ala Ala Val Trp Val Ala Ser Ala Val Val Val  
                165                 170                 175      
Leu Pro Val Val Val Phe Ser Gly Val Pro Arg Gly Met Ser Thr Cys  
            180                 185                 190          
His Met Gln Trp Pro Glu Pro Ala Ala Ala Trp Arg Thr Ala Phe Ile  
        195                 200                 205              
Ile Tyr Thr Ala Ala Leu Gly Phe Phe Gly Pro Leu Leu Val Ile Cys  
    210                 215                 220                  
Leu Cys Tyr Leu Leu Ile Val Val Lys Val Arg Ser Thr Thr Arg Arg  
225                 230                 235                 240  
Val Arg Ala Pro Ser Cys Gln Trp Val Gln Ala Pro Ala Cys Gln Arg  
                245                 250                 255      
Arg Arg Arg Ser Glu Arg Arg Val Thr Arg Met Val Val Ala Val Val  
            260                 265                 270          
Ala Leu Phe Val Leu Cys Trp Met Pro Phe Tyr Leu Leu Asn Ile Val  
        275                 280                 285              
Asn Val Val Cys Pro Leu Pro Glu Glu Pro Ala Phe Phe Gly Leu Tyr  
    290                 295                 300                  
Phe Leu Val Val Ala Leu Pro Tyr Ala Asn Ser Cys Ala Asn Pro Ile  
305                 310                 315                 320  
Leu Tyr Gly Phe Leu Ser Tyr Arg Phe Lys Gln Gly Phe Arg Arg Ile  
                325                 330                 335      
Leu Leu Arg Pro Ser Arg Arg Ile Arg Ser Gln Glu Pro Gly Ser Gly  
            340                 345                 350          
Pro Pro Glu Lys Thr Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Arg  
        355                 360                 365              
Arg Glu Glu Glu Glu Arg Arg Met Gln Arg Gly Gln Glu Met Asn Gly  
    370                 375                 380                  
Arg Leu Ser Gln Ile Ala Gln Ala Gly Thr Ser Gly Gln Gln Pro Arg  
385                 390                 395                 400  
Pro Cys Thr Gly Thr Ala Lys Glu Gln Gln Leu Leu Pro Gln Glu Ala  
                405                 410                 415      
Thr Ala Gly Asp Lys Ala Ser Thr Leu Ser His Leu                  
            420                 425                              



<210> 15
<211> 1258
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (65)..(1231)

<400> 15
ccgagctctc tggcgcagcg ctagctccgc cgcgctcagc tgccctgcgc cggcacccct 60    

ggtc atg agc gcc ccc tcg acg ctg ccc ccc ggg ggc gag gaa ggg ctg  109   
     Met Ser Ala Pro Ser Thr Leu Pro Pro Gly Gly Glu Glu Gly Leu
       1               5                  10                  15

ggg acg gcc tgg ccc tct gca gcc aat gcc agt agc gct ccg gcg gag   157   
Gly Thr Ala Trp Pro Ser Ala Ala Asn Ala Ser Ser Ala Pro Ala Glu
                 20                  25                  30    

gcg gag gag gcg gtg gcg ggg ccc ggg gac gcg cgg gcg gcg ggc atg   205   
Ala Glu Glu Ala Val Ala Gly Pro Gly Asp Ala Arg Ala Ala Gly Met
             35                  40                  45        

gtc gct atc cag tgc atc tac gcg ctg gtg tgc ctg gtg ggg ctg gtg   253   
Val Ala Ile Gln Cys Ile Tyr Ala Leu Val Cys Leu Val Gly Leu Val
         50                  55                  60            

ggc aac gcc ctg gtc atc ttc gtg atc ctt cgc tac gcc aag atg aag   301   
Gly Asn Ala Leu Val Ile Phe Val Ile Leu Arg Tyr Ala Lys Met Lys
     65                  70                  75                

acg gct acc aac atc tac ctg ctc aac ctg gcc gta gcc gac gag ctc   349   
Thr Ala Thr Asn Ile Tyr Leu Leu Asn Leu Ala Val Ala Asp Glu Leu
 80                  85                  90                  95

ttc atg ctg agc gtg ccc ttc gtg gcc tcg tcg gcc gcc ctg cgc cac   397   
Phe Met Leu Ser Val Pro Phe Val Ala Ser Ser Ala Ala Leu Arg His
                100                 105                 110    

tgg ccc ttc ggc tcc gtg ctg tgc cgc gcg gtg ctc agc gtc gac ggc   445   
Trp Pro Phe Gly Ser Val Leu Cys Arg Ala Val Leu Ser Val Asp Gly
            115                 120                 125        

ctc aac atg ttc acc agc gtc ttc tgt ctc acc gtg ctc agc gtg gac   493   
Leu Asn Met Phe Thr Ser Val Phe Cys Leu Thr Val Leu Ser Val Asp
        130                 135                 140            

cgc tac gtg gcc gtg gtg cac cct ctg cgc gcg gcg acc tac cgg cgg   541   
Arg Tyr Val Ala Val Val His Pro Leu Arg Ala Ala Thr Tyr Arg Arg
    145                 150                 155                

ccc agc gtg gcc aag ctc atc aac ctg ggc gtg tgg ctg gca tcc ctg   589   
Pro Ser Val Ala Lys Leu Ile Asn Leu Gly Val Trp Leu Ala Ser Leu
160                 165                 170                 175

ttg gtc act ctc ccc atc gcc atc ttc gca gac acc aga ccg gct cgc   637   
Leu Val Thr Leu Pro Ile Ala Ile Phe Ala Asp Thr Arg Pro Ala Arg
                180                 185                 190    

ggc ggc cag gcc gtg gcc tgc aac ctg cag tgg cca cac ccg gcc tgg   685   
Gly Gly Gln Ala Val Ala Cys Asn Leu Gln Trp Pro His Pro Ala Trp
            195                 200                 205        

tcg gca gtc ttc gtg gtc tac act ttc ctg ctg ggc ttc ctg ctg ccc   733   
Ser Ala Val Phe Val Val Tyr Thr Phe Leu Leu Gly Phe Leu Leu Pro
        210                 215                 220            

gtg ctg gcc att ggc ctg tgc tac ctg ctc atc gtg ggc aag atg cgc   781   
Val Leu Ala Ile Gly Leu Cys Tyr Leu Leu Ile Val Gly Lys Met Arg
    225                 230                 235                

gcc gtg gcc ctg cgc gct ggc tgg cag cag cgc agg cgc tcg gag aag   829   
Ala Val Ala Leu Arg Ala Gly Trp Gln Gln Arg Arg Arg Ser Glu Lys
240                 245                 250                 255

aaa atc acc agg ctg gtg ctg atg gtc gtg gtc gtc ttt gtg ctc tgc   877   
Lys Ile Thr Arg Leu Val Leu Met Val Val Val Val Phe Val Leu Cys
                260                 265                 270    

tgg atg cct ttc tac gtg gtg cag ctg ctg aac ctc ttc gtg acc agc   925   
Trp Met Pro Phe Tyr Val Val Gln Leu Leu Asn Leu Phe Val Thr Ser
            275                 280                 285        

ctt gat gcc acc gtc aac cac gtg tcc ctt atc ctt agc tat gcc aac   973   
Leu Asp Ala Thr Val Asn His Val Ser Leu Ile Leu Ser Tyr Ala Asn
        290                 295                 300            

agc tgc gcc aac ccc att ctc tat ggc ttc ctc tcc gac aac ttc cgc   1021  
Ser Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser Asp Asn Phe Arg
    305                 310                 315                

cga ttc ttc cag cgg gtt ctc tgc ctg cgc tgc tgc ctc ctg gaa ggt   1069  
Arg Phe Phe Gln Arg Val Leu Cys Leu Arg Cys Cys Leu Leu Glu Gly
320                 325                 330                 335

gct gga ggt gct gag gag gag ccc ctg gac tac tat gcc act gct ctc   1117  
Ala Gly Gly Ala Glu Glu Glu Pro Leu Asp Tyr Tyr Ala Thr Ala Leu
                340                 345                 350    

aag agc aaa ggt ggg gca ggg tgc atg tgc ccc cca ctc ccc tgc cag   1165  
Lys Ser Lys Gly Gly Ala Gly Cys Met Cys Pro Pro Leu Pro Cys Gln
            355                 360                 365        

cag gaa gcc ctg caa cca gaa ccc ggc cgc aag cgc atc ccc ctc acc   1213  
Gln Glu Ala Leu Gln Pro Glu Pro Gly Arg Lys Arg Ile Pro Leu Thr
        370                 375                 380            

agg acc acc acc ttc tga ggagcccttc ccctacccac cctgcgt             1258  
Arg Thr Thr Thr Phe                                  
    385                                              


<210> 16
<211> 388        
<212> PRT
<213> Homo sapiens

<400> 16
Met Ser Ala Pro Ser Thr Leu Pro Pro Gly Gly Glu Glu Gly Leu Gly  
  1               5                  10                  15      
Thr Ala Trp Pro Ser Ala Ala Asn Ala Ser Ser Ala Pro Ala Glu Ala  
             20                  25                  30          
Glu Glu Ala Val Ala Gly Pro Gly Asp Ala Arg Ala Ala Gly Met Val  
         35                  40                  45              
Ala Ile Gln Cys Ile Tyr Ala Leu Val Cys Leu Val Gly Leu Val Gly  
     50                  55                  60                  
Asn Ala Leu Val Ile Phe Val Ile Leu Arg Tyr Ala Lys Met Lys Thr  
 65                  70                  75                  80  
Ala Thr Asn Ile Tyr Leu Leu Asn Leu Ala Val Ala Asp Glu Leu Phe  
                 85                  90                  95      
Met Leu Ser Val Pro Phe Val Ala Ser Ser Ala Ala Leu Arg His Trp  
            100                 105                 110          
Pro Phe Gly Ser Val Leu Cys Arg Ala Val Leu Ser Val Asp Gly Leu  
        115                 120                 125              
Asn Met Phe Thr Ser Val Phe Cys Leu Thr Val Leu Ser Val Asp Arg  
    130                 135                 140                  
Tyr Val Ala Val Val His Pro Leu Arg Ala Ala Thr Tyr Arg Arg Pro  
145                 150                 155                 160  
Ser Val Ala Lys Leu Ile Asn Leu Gly Val Trp Leu Ala Ser Leu Leu  
                165                 170                 175      
Val Thr Leu Pro Ile Ala Ile Phe Ala Asp Thr Arg Pro Ala Arg Gly  
            180                 185                 190          
Gly Gln Ala Val Ala Cys Asn Leu Gln Trp Pro His Pro Ala Trp Ser  
        195                 200                 205              
Ala Val Phe Val Val Tyr Thr Phe Leu Leu Gly Phe Leu Leu Pro Val  
    210                 215                 220                  
Leu Ala Ile Gly Leu Cys Tyr Leu Leu Ile Val Gly Lys Met Arg Ala  
225                 230                 235                 240  
Val Ala Leu Arg Ala Gly Trp Gln Gln Arg Arg Arg Ser Glu Lys Lys  
                245                 250                 255      
Ile Thr Arg Leu Val Leu Met Val Val Val Val Phe Val Leu Cys Trp  
            260                 265                 270          
Met Pro Phe Tyr Val Val Gln Leu Leu Asn Leu Phe Val Thr Ser Leu  
        275                 280                 285              
Asp Ala Thr Val Asn His Val Ser Leu Ile Leu Ser Tyr Ala Asn Ser  
    290                 295                 300                  
Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser Asp Asn Phe Arg Arg  
305                 310                 315                 320  
Phe Phe Gln Arg Val Leu Cys Leu Arg Cys Cys Leu Leu Glu Gly Ala  
                325                 330                 335      
Gly Gly Ala Glu Glu Glu Pro Leu Asp Tyr Tyr Ala Thr Ala Leu Lys  
            340                 345                 350          
Ser Lys Gly Gly Ala Gly Cys Met Cys Pro Pro Leu Pro Cys Gln Gln  
        355                 360                 365              
Glu Ala Leu Gln Pro Glu Pro Gly Arg Lys Arg Ile Pro Leu Thr Arg  
    370                 375                 380                  
Thr Thr Thr Phe                                                  
385                                                              



<210> 17
<211> 1898
<212> DNA
<213> Mus musculus

<220> 
<221> CDS
<222> (86)..(1240)

<400> 17
gaccccagcc cagcctcttg gtccttggct cacggtccgc tgctctccac gcattccgct 60    

gctccggggt gggctacccc gagac atg aac gcg cca gca act ctg ctc cgg   112   
                            Met Asn Ala Pro Ala Thr Leu Leu Arg
                              1               5                

ggg gtc gag gac acc acc tgg acc cct ggg atc aac gcc agc tgg gct   160   
Gly Val Glu Asp Thr Thr Trp Thr Pro Gly Ile Asn Ala Ser Trp Ala
 10                  15                  20                  25

ccg gag cag gag gag gat gcg atg ggg tcc gac ggc aca ggg aca gcg   208   
Pro Glu Gln Glu Glu Asp Ala Met Gly Ser Asp Gly Thr Gly Thr Ala
                 30                  35                  40    

ggc atg gtc act atc cag tgc atc tat gcg ctc gtg tgt ctg gtg ggc   256   
Gly Met Val Thr Ile Gln Cys Ile Tyr Ala Leu Val Cys Leu Val Gly
             45                  50                  55        

ctg gtg gga aac gcc ctg gtc atc ttc gtg atc cta cgc tat gcc aag   304   
Leu Val Gly Asn Ala Leu Val Ile Phe Val Ile Leu Arg Tyr Ala Lys
         60                  65                  70            

atg aag aca gcc acc aac atc tac cta ctc aac ctg gcc gtc gcc gat   352   
Met Lys Thr Ala Thr Asn Ile Tyr Leu Leu Asn Leu Ala Val Ala Asp
     75                  80                  85                

gag ctc ttc atg ctc agc gtg cca ttc gtg cgc tcg gcg gct gcc ctg   400   
Glu Leu Phe Met Leu Ser Val Pro Phe Val Arg Ser Ala Ala Ala Leu
 90                  95                 100                 105

cgc cac tgg ccg ttc ggg gcg gtg ctg tgt cgc gca gtg ctt agc gtg   448   
Arg His Trp Pro Phe Gly Ala Val Leu Cys Arg Ala Val Leu Ser Val
                110                 115                 120    

gac ggc ctg aac atg ttc act agt gtc ttc tgc ctc acc gtg ctc agc   496   
Asp Gly Leu Asn Met Phe Thr Ser Val Phe Cys Leu Thr Val Leu Ser
            125                 130                 135        

gtg gac cgc tat gtg gct gtt gtg cac cct ctg cgc acc gcc acc tac   544   
Val Asp Arg Tyr Val Ala Val Val His Pro Leu Arg Thr Ala Thr Tyr
        140                 145                 150            

cgg cgg ccc agc gtg gcc aag cta atc aac ctg gga gtg tgg cta gca   592   
Arg Arg Pro Ser Val Ala Lys Leu Ile Asn Leu Gly Val Trp Leu Ala
    155                 160                 165                

tcc ttg ctg gtc acc ctg ccc atc gca gtc ttc gct gac acc agg cca   640   
Ser Leu Leu Val Thr Leu Pro Ile Ala Val Phe Ala Asp Thr Arg Pro
170                 175                 180                 185

gct cgt ggg ggt gag gcc gtg gct tgc aac ctg cac tgg cct cac ccg   688   
Ala Arg Gly Gly Glu Ala Val Ala Cys Asn Leu His Trp Pro His Pro
                190                 195                 200    

gcc tgg tct gcg gtc ttt gtg atc tat act ttt ttg ttg ggc ttc cta   736   
Ala Trp Ser Ala Val Phe Val Ile Tyr Thr Phe Leu Leu Gly Phe Leu
            205                 210                 215        

ccc ccg gtt ctg gcc atc gga tta tgc tac ctg ctt att gtg ggc aag   784   
Pro Pro Val Leu Ala Ile Gly Leu Cys Tyr Leu Leu Ile Val Gly Lys
        220                 225                 230            

atg cgc gct gtg gcc ctg cgc ggt ggc tgg caa caa cgg agg cgc tca   832   
Met Arg Ala Val Ala Leu Arg Gly Gly Trp Gln Gln Arg Arg Arg Ser
    235                 240                 245                

gag aag aag atc act agg ctc gtg cta atg gtg gtg acc gtc ttt gtg   880   
Glu Lys Lys Ile Thr Arg Leu Val Leu Met Val Val Thr Val Phe Val
250                 255                 260                 265

cta tgc tgg atg cct ttc tat gtg gtg cag ctt ctg aac ctg ttt gtc   928   
Leu Cys Trp Met Pro Phe Tyr Val Val Gln Leu Leu Asn Leu Phe Val
                270                 275                 280    

acc agc ctc gat gcc act gtc aac cat gtg tcc ctc atc ctg agc tat   976   
Thr Ser Leu Asp Ala Thr Val Asn His Val Ser Leu Ile Leu Ser Tyr
            285                 290                 295        

gcc aac agc tgt gcc aat ccc att ctc tat ggc ttc ctc tct gac aac   1024  
Ala Asn Ser Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser Asp Asn
        300                 305                 310            

ttc cgg cgc tct ttc cag cgg gtt ctg tgc ctg cgc tgc tgt ctc ctg   1072  
Phe Arg Arg Ser Phe Gln Arg Val Leu Cys Leu Arg Cys Cys Leu Leu
    315                 320                 325                

gaa aca act gga ggt gct gag gaa gag ccc ctg gac tac tat gcc act   1120  
Glu Thr Thr Gly Gly Ala Glu Glu Glu Pro Leu Asp Tyr Tyr Ala Thr
330                 335                 340                 345

gct ctc aaa agc aga ggg ggt gca gga tgc ata tgc cct cct ctg ccc   1168  
Ala Leu Lys Ser Arg Gly Gly Ala Gly Cys Ile Cys Pro Pro Leu Pro
                350                 355                 360    

tgc cag cag gag ccc gtg caa gca gaa cct ggc tgc aag caa gtc cct   1216  
Cys Gln Gln Glu Pro Val Gln Ala Glu Pro Gly Cys Lys Gln Val Pro
            365                 370                 375        

ttc acc aag acc act act ttc tga aaaccatttt accctccctc acctcgcctg  1270  
Phe Thr Lys Thr Thr Thr Phe                                     
        380                 385                                 

caaacgggtc tgcgccactc tctcaagcca gcaacttcaa gaacaactcc tgttttcact 1330  

aagccaggcc ctttcagcag cctgtgtgct gtccccagga gcctcaggac tcctgctagt 1390  

ccctccctct cctaggactg gctccaagga cacctccatg ggggtaggac tgccctggga 1450  

tttgggctaa agtaccatcc attcctgggc ctctggcaat ttttcaagag gtgggaagca 1510  

ggtggtggtc agaaaggaat gtctaccctt gtgtgacttg tgacagtgac tgcttgaaag 1570  

agcccttggg aggctgaggt aggcagagct gtgctctgtg taggctcttt gctgtatggt 1630  

agcatagtgt gtatggtgag acaagggaga agataggata actccaagtg gtttccctct 1690  

gtgtcggtct gaggctctcg ttgctaagtg agatgtctac gtaacagacg aagggcactt 1750  

gcactgtcac tgtacaagtg ttttccagtt gtcaaggggc cagtagagac ttcctgtgag 1810  

tgtgaaaggc ttaaagaagc atgatgtggg gcggtttttg caaggcataa aacttctggt 1870  

caggaattca aaggcagaag gattaaaa                                    1898  


<210> 18
<211> 384        
<212> PRT
<213> Mus musculus

<400> 18
Met Asn Ala Pro Ala Thr Leu Leu Arg Gly Val Glu Asp Thr Thr Trp  
  1               5                  10                  15      
Thr Pro Gly Ile Asn Ala Ser Trp Ala Pro Glu Gln Glu Glu Asp Ala  
             20                  25                  30          
Met Gly Ser Asp Gly Thr Gly Thr Ala Gly Met Val Thr Ile Gln Cys  
         35                  40                  45              
Ile Tyr Ala Leu Val Cys Leu Val Gly Leu Val Gly Asn Ala Leu Val  
     50                  55                  60                  
Ile Phe Val Ile Leu Arg Tyr Ala Lys Met Lys Thr Ala Thr Asn Ile  
 65                  70                  75                  80  
Tyr Leu Leu Asn Leu Ala Val Ala Asp Glu Leu Phe Met Leu Ser Val  
                 85                  90                  95      
Pro Phe Val Arg Ser Ala Ala Ala Leu Arg His Trp Pro Phe Gly Ala  
            100                 105                 110          
Val Leu Cys Arg Ala Val Leu Ser Val Asp Gly Leu Asn Met Phe Thr  
        115                 120                 125              
Ser Val Phe Cys Leu Thr Val Leu Ser Val Asp Arg Tyr Val Ala Val  
    130                 135                 140                  
Val His Pro Leu Arg Thr Ala Thr Tyr Arg Arg Pro Ser Val Ala Lys  
145                 150                 155                 160  
Leu Ile Asn Leu Gly Val Trp Leu Ala Ser Leu Leu Val Thr Leu Pro  
                165                 170                 175      
Ile Ala Val Phe Ala Asp Thr Arg Pro Ala Arg Gly Gly Glu Ala Val  
            180                 185                 190          
Ala Cys Asn Leu His Trp Pro His Pro Ala Trp Ser Ala Val Phe Val  
        195                 200                 205              
Ile Tyr Thr Phe Leu Leu Gly Phe Leu Pro Pro Val Leu Ala Ile Gly  
    210                 215                 220                  
Leu Cys Tyr Leu Leu Ile Val Gly Lys Met Arg Ala Val Ala Leu Arg  
225                 230                 235                 240  
Gly Gly Trp Gln Gln Arg Arg Arg Ser Glu Lys Lys Ile Thr Arg Leu  
                245                 250                 255      
Val Leu Met Val Val Thr Val Phe Val Leu Cys Trp Met Pro Phe Tyr  
            260                 265                 270          
Val Val Gln Leu Leu Asn Leu Phe Val Thr Ser Leu Asp Ala Thr Val  
        275                 280                 285              
Asn His Val Ser Leu Ile Leu Ser Tyr Ala Asn Ser Cys Ala Asn Pro  
    290                 295                 300                  
Ile Leu Tyr Gly Phe Leu Ser Asp Asn Phe Arg Arg Ser Phe Gln Arg  
305                 310                 315                 320  
Val Leu Cys Leu Arg Cys Cys Leu Leu Glu Thr Thr Gly Gly Ala Glu  
                325                 330                 335      
Glu Glu Pro Leu Asp Tyr Tyr Ala Thr Ala Leu Lys Ser Arg Gly Gly  
            340                 345                 350          
Ala Gly Cys Ile Cys Pro Pro Leu Pro Cys Gln Gln Glu Pro Val Gln  
        355                 360                 365              
Ala Glu Pro Gly Cys Lys Gln Val Pro Phe Thr Lys Thr Thr Thr Phe  
    370                 375                 380                  



<210> 19
<211> 10494
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (7926)..(9020)

<400> 19
ggccagggga ctcctgccca gaactcaggg tggccgatgt ggggaggggc actgtggggc 60    

cgacaggtcc cctctctggc catcaggccc ccaggagggc ccaggtgctt ggaggtgggg 120   

ggtgtcccag cttgatgttg gggatgtgag tagatccagc gcccacccac ccgcagggct 180   

gagctcccac tgggcgctgg gccgtgactc gcacaccgga ccctgcaccc ctggggcacc 240   

cagtgattcc agaacagtgg gaccccagag gcttctcagg gagccccaga acatgacaga 300   

tgggggccca ggtgcgaggc agtgggagct ggaggaacac agccaggggc tgaggcgaga 360   

accatgagga tggtgggcag aggctgaggg gaggggcagc agatggagat gggggaggag 420   

ttaggggtca caaagggggt tctcagagga tctgccttgg gaagccactg ctgtgggagg 480   

gtgggaggga tacagcccag gtacctccag agaggatgga aaggcttatg gggcggattc 540   

tgggcagggg acctgggacc agcctgcagc ctcccctgag ggcctggcca tggccgcagg 600   

ctggggagga ggggagggga ccttggggcc aggtgccatg gtcctctaag cactcttgct 660   

cgatggtaaa cataacacgc gctgcttgca gaacatgtgg aaacactgaa acgcttaaag 720   

gagagaacat ggtcccggta cccggccttc aagggagctg ctggcgcctg ttcaacagga 780   

gccgacccca cctgtgaaca gacggcaggc ggctgctccc atgtcccctc agagaggggc 840   

cctccgagtt ctgctgtcac ctgggggcgc ctcacttcat tcagccagtg gcggggctcc 900   

ctgggtcggc acagagtcag gggagggggc tgggggacct cctggtggga aaatgtccgg 960   

tgatccccag cctccgcgct cagcgggagg aggcgctcgg tcccgcttct tacaaccagc 1020  

ggcgctcacg gcgggcccgg ggatcagcat cccgggagct tctcaggaat gcagattccc 1080  

aggccctcac tgcctgggga gtcgggggcc cagctcgagg cccaggaatc tgctttgagg 1140  

acccaggtga ctctgctgcc tgcctgagaa ccccacctta ggtgagggac taaggtgtac 1200  

ccatggattc atttcagggg aaataaaaag aacaacttag caggtagtct atgcttaaat 1260  

atgtgtagga tccacaaata aggcatggat aaaacccgag tggagtgtcc tggaaatccc 1320  

acgaccacgg acccccctcg ctggggctgc ctgccgcccc caccagcctc cacacaccca 1380  

cttatctcca caaccccagc ccacccctca gagacgtctg cagagcccct gaccctctcc 1440  

ccttgaacaa ggaccctcca ccctcttcag actctcgacg agggaccccc tggactcctg 1500  

ctggcggcag gacccccacc ccaagctggg gtctaccaca gagcggacag caagaaaata 1560  

gggtgggggc gcaggcgatc atggggtcac tgccagtggg accagggctg tgggcgagtg 1620  

cgccagggtt cccggaggcc agacgtggga cccgggagtc gagcaggtga agcggccctg 1680  

ccccgccccc accaggcact ggccccgccc ccgccccgcc ccgccccctc ccagccggcg 1740  

cccgggagcc cggagccagt gccgcgcgga catcggggct cccccgttca gagggcgccg 1800  

ccgcccaggt gagtgccgcc cgccccatgt ccccctcccg cgcgggcacc ccctgccctc 1860  

ggctgttatc cccactgggg gtttcaccct gtgtgcgcag ccccggcccg gggtcccgcc 1920  

gtgcgccccc agcccgctgc acgcactgtc ccccacgcgc cctccgcaca cccgcggggc 1980  

tctcctgccg ccgccggggg tccctcccct cccgttccat ccactcccag cagctccatc 2040  

cctcccatct cctgccccca ccccacaact caccatctgc aggcaccccg tgtgccaggg 2100  

tcagcccaga agccacaggg gacccagatg gccccactct gcccaccgcg ccgctcccgg 2160  

cctctcctcc ccacgacggg ggccacagcg gggctggctc ctggagctgg aggagggtgg 2220  

gtaaggctgg ggagggctcg gagcctgggg ctgggggccg gaagtggcac tcaggccaca 2280  

gggaaccact gggccacgga aggagggtcc cagggtgccc gtggcaccca gcgaggggag 2340  

gatccgcaat ttgggtgccg ggggaggcaa ctggtgcctg cgcgcagctg ggtcggtgag 2400  

ctcctggaag gcagcaggca gaggccagca cccaggggcc ctgtgacctg gcactcacag 2460  

atgggttccc tgaaacccaa gactggggag gctggggtgc caccccgccc gctgcgaaca 2520  

gagccccctc ctgtccaagg caccgcgtgt acctggaatc ctcctggcgt cttcaccctc 2580  

tccagaatag agaacacgcc actggggtgt gtgcccttgg ccctcctccc ccaccccaga 2640  

cccacccacg tgcccgaccc gctgtcccca gcctgccagc ctgcctgggg ccccctcaag 2700  

ggcaagagag cggagtgcat ggtgacagaa gttggggatg gttccagtga ggctgagccc 2760  

tttctgaagg cagtgattct ggactatgta ggtggggact gccagagcct cctgggcaga 2820  

aactggtcaa cagcaccaag gacaggcgcc tggcgttgat ttccagagca agacccagcg 2880  

aggctgtcag gaggtgcctg gtgtggaggg tgccccgaga agcgttcgcg gagcacgcgg 2940  

gacccctgct gctgctgctc caggctggcc cacacctgcc tcagtttccc tctcctgggg 3000  

agggtatgtg cccctggcca caggctgccg cagggacagg tggcgtgtat gtgggggaca 3060  

ggcaggggtg ccattggctg cactcacaga gctggacccc aagggggcag tggcctgcca 3120  

ccaggccacc cttacgacag aggaaacagg tcagaacgct tgtcctggga gcacaggcct 3180  

ggctccgggg cctttggagg ggctggggcc tgtagtctta gctagggtgt cccccgacgt 3240  

ttgcccctgc ccagcacaca atggaggagc ccgggtgggt ctgcagcctc tccagggtgc 3300  

ggcgtgggcc ccggccgtgt gagccgctgc ctccccgagc agcaggttcc gcagcccctc 3360  

caagctgcag ccgcatcgct gccccccatg aaggagccga ctccccgacc tcgtgctggg 3420  

ttagcctgga aggagttggc agggtgcagg ctagacctcc acccagtcat ggaggacttg 3480  

gtgctgaggc cccgcctctg gtcccaggcc cctgtgaaga ctgccccctt ctccgaggag 3540  

cccagcggcc tcctggatgc tggggaaatg ctgggctgct tagggcagct tgtgggagca 3600  

atcgttgagc gcccagtgta tgccagcccc gctgtggtcc ccgtcgtggg gaggtgaggc 3660  

cgggagcggt gctgtgggca gactggggcc atctgggtcc cctgtggctt ctgggctgac 3720  

cctggcacac cgggcacctg cagatggtga gttgtggggt gggggcagga gatgggaggg 3780  

atggatgctg ctgggagtgg atgcacgcag caccctgcac acagaagctc actcagtttc 3840  

atcagctcag caaccctaca gtttgcagga gttgcctatc ccagaagctg ggctcagaga 3900  

agcccgtgac ttaccccaga ccacgcagcc cgtgtgggga gtggtcaggg gccggggtct 3960  

ctcccagtgc catgtcaggc tgagcagatc ccttcgtggc cgagggctcg ggatcagaaa 4020  

gctcctactg ctggctcccc ctccagtgaa tcccccaccc acaagggaca gggccaccgg 4080  

gacaattccc cgtgagtgcg taattttatg attcagagga tactgcttcc aaataacggc 4140  

tcttgcagaa ttatgttcca agagtcaggt acagcaataa tggtctattt gtgtcctttg 4200  

ctgctctgaa gtctaactcc ggaggtggag cactgggggc cgcagagccg gggacctggc 4260  

agcctgtgga gcccctcgct gggctctggg catgggagtg gccttggagg aaccctgagg 4320  

ctcctctgaa gctaagaagc tacaaagaca gggaggctga ggcaggagga tcacttgagc 4380  

acaggtcgag gctgcagtga gctgtgatca cagcaccact tcgatccagc tcgggcaaca 4440  

gagcaagacc ccatctcgaa aacaaaaaat caaacaggca tttgggaacc acacgtgctg 4500  

gggacccagg gcctgtgttg gagatggacc ggagcccgac agccgccctc tccctgtccc 4560  

accatcggtg gctcctctgt cccctccacc tggcctcctt gctacggagg aatgggccga 4620  

aagtgcctcc ccagggaggg tgcagctcag aggcctctgc acctgggccg ccatcccacc 4680  

cacctggact cccacgcagc ccgcgggctg tctccagacc actgtccttc cggaatgcat 4740  

gctccacagg cagccagagg gagccgcaaa catggcgtgt tggatttcca tgctggtccc 4800  

tggggagcgg agagccacag gcctcttccc ctccctctcc ctctccctcc ctccctctct 4860  

ccccctaccc tgtctctctc tctccccccc cactctctct ccctccctct ctccccccac 4920  

cctgtctttc tctctccctc cccacctccc cctctctctc cctccccctc ctcccctccc 4980  

cctccctttc cctccctctc tccctctctc ctcgccgcct ccccatccct ctccctctcc 5040  

ctcctctctc tctcccctac cctgtctttc tctctgcctc cccgcctccc cttccctctc 5100  

cccccacctt ttctctctcc ctccccacct ccccctccct ctccctcccc cctcacctcc 5160  

cctccctttc cctccctctc tccctctctc ctccccgcct ccccatccct ctccctctcc 5220  

ctcctctctc tctcccccta ccctgttttc tctctccctc cccgcctccc cctccctctc 5280  

ccccataccc tatctttctc tctccctccc tgccacccac tccctctccc tctccctctc 5340  

cctctccctc cctctctccc cacaccctgt ctttctttct ccctccccac ctcccctctt 5400  

ctcccacccc cggggtctgc gtggaggcca ctgctccgtc cctgctgagg attctgctgc 5460  

actctggctc ctgcctgtgg gaatccgtcc tgtctctctg gctggtgtct ctctggctgg 5520  

cgtccctgcc cagatgccgc agcttgatgg ggatgctctt tcattccttt atgctgcttg 5580  

ggacaggtgc gctcccagaa gggatcctgt cgccagttct gggggagccc agccatgctc 5640  

tccccctgcc caccccacag agccctctct ggaccttgtg ccagcaccct gctccagtga 5700  

atctttcaac cctcttccca ttcaccaatt ctctcttcag tgctgtccac actggagttg 5760  

gttctgacca cttttgtagt gtttttttcc acttaaatga ttgtattttt tacatccagg 5820  

atttgtaatt tttaaaaata gatgcctgtt cattttactc cttagacaga agccaaatgt 5880  

atttcctaac attttatcca tgctgtctct gtggatcctg cacatattta aacatagcct 5940  

aagcgtacct gtttgctcgt tatttttatc tccctgagat ggatccatgg gtccactggc 6000  

cctgttgatt ttctgagtcg tatttcttag tgtgtttggg ccatgcgagc ttggggatgt 6060  

tgatttctag gtttgttggg gacagagggc tttctctttg tgctgtcagc cttgtgttct 6120  

gggctccccc gtccccagct ctcctttcct tgtctaccag atttcagtgg ccttggccca 6180  

gccccacagc ccccagccag gactgtggcc tttcctggca gctgctgggg tcgtcctgtg 6240  

ctctgaggtg cctccagggt cagggccggt cagctgagca gccccagggc tccagacggc 6300  

acatgctgag gtcaccacag ccggctccac ccctgctcag gccgaggtcc cccagggagg 6360  

ggcttgtccc tggtctggat cctaggggac actttgattc tctgctggcc acccccagag 6420  

tcacacagct ccagggtcaa cccaaacatc cggacttcct ccgccccact cgtcagggga 6480  

ggcattgatc ttctttttga gacagggtct tgctcagtca cccaggctgg cgtgcagtgg 6540  

tgtaatcaca gctcactgca gcctcaacct cctgggctca aatgatcctc ctgactcagc 6600  

ctcctcagtg gctgggacta caggcgcccg ccaccacact tggctaattt ttgtattttt 6660  

tgtagagacg ggggtctcac catgttgccc aggctggtct tgaactcctg tcctcaggtg 6720  

atccacccgc ctcggcctcc cacagtgctg ggatgacagg cttgagccac tgcacccagc 6780  

cggagtatca tttttatgaa tgatttcaaa catgcagaaa aatacaaaaa caatatacga 6840  

ggtacacacg tgcccatggc cttggaccca cagacgtcac cattcccagc ccacccttct 6900  

ccatggacac ccctccctcc cctcccccaa gtctcccctg ttctctctct gggccacagt 6960  

ggggggttcc agggcctggg agggggctca aagctccgat gggactgggc agtgtcaggt 7020  

ggctgcagcc cccatacgct atgcctctga cccgcccaca ccccccaccg cggcttctcc 7080  

tccgggctgc agggtgtgca gcccccgccc gcagtccccc ctccttcgcc ctgtgtgact 7140  

cctggggctc cgtgtgacca ctctgtgtgg tttgtgtgtt tgcttctctg cagccgcccc 7200  

gtggggaggg tggtgtctct ctggccctgt gctgtgcccc cgcctgggtt tacagatgtc 7260  

tgtcattgct gtgggggtga cggtccctgc gctggcctgg agagaggttc ggggccaacg 7320  

ggcagcgggc accccggtga aagtccctcg aggctgcggt ggcgacacca cgtccagcca 7380  

cttctcaggt cgtcctagcc aggtgccatt catcccaggc ggacaggggg ccgaccaccg 7440  

gccccatctc tctccactgc cacctctccc tgtgtgtccc gggaggggcc gcccgctggg 7500  

cctcggctcc ttacctggta gacgagggca gcagcactgc agggcaggct ctgaggggct 7560  

tcagggagac gcaggtgctg gcctcagact ccaggatgct gcggccaggc caggcgccat 7620  

ctgggtgcag gggcggccac agggcagctg tcgccatatc gacagcagcc gtccgtctgg 7680  

gctcccgggg ccacctgccc gccgctcctt cctctcctgg cttattttcc aaacaatttg 7740  

cttaacgtga ttcccggcca agctaaacat gactaatcgt gtttacccgg tgatcccgcg 7800  

cctcctggca ggcggggctg gggcccagga ggaaggaatg cctgcatgtg ctggttcagg 7860  

gactcaccac cctggcgtcc tcccttcttc tcttgcagag cctgacgcac cccagggctg 7920  

ccgcc atg gag ccc ctg ttc cca gcc tcc acg ccc agc tgg aac gcc tcc 7970  
      Met Glu Pro Leu Phe Pro Ala Ser Thr Pro Ser Trp Asn Ala Ser
        1               5                  10                  15

tcc ccg ggg gct gcc tct gga ggc ggt gac aac agg acg ctg gtg ggg   8018  
Ser Pro Gly Ala Ala Ser Gly Gly Gly Asp Asn Arg Thr Leu Val Gly
                 20                  25                  30    

ccg gcg ccc tcg gca ggg gcc cgg gcg gtg ctg gtg ccc gtg ctg tac   8066  
Pro Ala Pro Ser Ala Gly Ala Arg Ala Val Leu Val Pro Val Leu Tyr
             35                  40                  45        

ctg ctg gtg tgt gcg gcc ggg ctg ggc ggg aac acg ctg gtc atc tac   8114  
Leu Leu Val Cys Ala Ala Gly Leu Gly Gly Asn Thr Leu Val Ile Tyr
         50                  55                  60            

gtg gtg ctg cgc ttc gcc aag atg aag acc gtc acc aac atc tac att   8162  
Val Val Leu Arg Phe Ala Lys Met Lys Thr Val Thr Asn Ile Tyr Ile
     65                  70                  75                

ctc aac ctg gca gtg gcc gac gtc ctg tac atg ctg ggg ctg cct ttc   8210  
Leu Asn Leu Ala Val Ala Asp Val Leu Tyr Met Leu Gly Leu Pro Phe
 80                  85                  90                  95

ctg gcc acg cag aac gcc gcg tcc ttc tgg ccc ttc ggc ccc gtc ctg   8258  
Leu Ala Thr Gln Asn Ala Ala Ser Phe Trp Pro Phe Gly Pro Val Leu
                100                 105                 110    

tgc cgc ctg gtc atg acg ctg gac ggc gtc aac cag ttc acc agt gtc   8306  
Cys Arg Leu Val Met Thr Leu Asp Gly Val Asn Gln Phe Thr Ser Val
            115                 120                 125        

ttc tgc ctg aca gtc atg agc gtg gac cgc tac ctg gca gtg gtg cac   8354  
Phe Cys Leu Thr Val Met Ser Val Asp Arg Tyr Leu Ala Val Val His
        130                 135                 140            

ccg ctg agc tcg gcc cgc tgg cgc cgc ccg cgt gtg gcc aag ctg gcg   8402  
Pro Leu Ser Ser Ala Arg Trp Arg Arg Pro Arg Val Ala Lys Leu Ala
    145                 150                 155                

agc gcc gcg gcc tgg gtc ctg tct ctg tgc atg tcg ctg ccg ctc ctg   8450  
Ser Ala Ala Ala Trp Val Leu Ser Leu Cys Met Ser Leu Pro Leu Leu
160                 165                 170                 175

gtg ttc gcg gac gtg cag gag ggc ggt acc tgc aac gcc agc tgg ccg   8498  
Val Phe Ala Asp Val Gln Glu Gly Gly Thr Cys Asn Ala Ser Trp Pro
                180                 185                 190    

gag ccc gtg ggg ctg tgg ggc gcc gtc ttc atc atc tac acg gcc gtg   8546  
Glu Pro Val Gly Leu Trp Gly Ala Val Phe Ile Ile Tyr Thr Ala Val
            195                 200                 205        

ctg ggc ttc ttc gcg ccg ctg ctg gtc atc tgc ctg tgc tac ctg ctc   8594  
Leu Gly Phe Phe Ala Pro Leu Leu Val Ile Cys Leu Cys Tyr Leu Leu
        210                 215                 220            

atc gtg gtg aag gtg agg gcg gcg ggc gtg cgc gtg ggc tgc gtg cgg   8642  
Ile Val Val Lys Val Arg Ala Ala Gly Val Arg Val Gly Cys Val Arg
    225                 230                 235                

cgg cgc tcg gag cgg aag gtg acg cgc atg gtg ttg gtg gtg gtg ctg   8690  
Arg Arg Ser Glu Arg Lys Val Thr Arg Met Val Leu Val Val Val Leu
240                 245                 250                 255

gtg ttt gcg gga tgt tgg ctg ccc ttc ttc acc gtc aac atc gtc aac   8738  
Val Phe Ala Gly Cys Trp Leu Pro Phe Phe Thr Val Asn Ile Val Asn
                260                 265                 270    

ctg gcc gtg gcg ctg ccc cag gag ccc gcc tcc gcc ggc ctc tac ttc   8786  
Leu Ala Val Ala Leu Pro Gln Glu Pro Ala Ser Ala Gly Leu Tyr Phe
            275                 280                 285        

ttc gtg gtc atc ctc tcc tac gcc aac agc tgt gcc aac ccc gtc ctc   8834  
Phe Val Val Ile Leu Ser Tyr Ala Asn Ser Cys Ala Asn Pro Val Leu
        290                 295                 300            

tac ggc ttc ctc tct gac aac ttc cgc cag agc ttc cag aag gtt ctg   8882  
Tyr Gly Phe Leu Ser Asp Asn Phe Arg Gln Ser Phe Gln Lys Val Leu
    305                 310                 315                

tgc ctc cgc aag ggc tct ggt gcc aag gac gct gac gcc acg gag ccg   8930  
Cys Leu Arg Lys Gly Ser Gly Ala Lys Asp Ala Asp Ala Thr Glu Pro
320                 325                 330                 335

cgt cca gac agg atc cgg cag cag cag gag gcc acg ccg ccc gcg cac   8978  
Arg Pro Asp Arg Ile Arg Gln Gln Gln Glu Ala Thr Pro Pro Ala His
                340                 345                 350    

cgc gcc gca gcc aac ggg ctt atg cag acc agc aag ctg tga           9020  
Arg Ala Ala Ala Asn Gly Leu Met Gln Thr Ser Lys Leu    
            355                 360                 365

gagtgcaggc ggggggtggg cggccccgtg tcacccccag gagcggaggt tgcactgcgg 9080  

tgacccccac ccatgacctg ccagtcagga tgctccccgg cggtggtgtg aggacagagc 9140  

tggctgaagc caggctgggg tagacacagg gcagtaggtt ccccaccgtg accgaccatc 9200  

ccctctaacc gtctgccaca cagcgggggc tcccgggagg taggggaggt ggccagaccg 9260  

gtggggggct ccgccatgcc gtgcaagtgc tcagggccgc ctcaccctcc atctggcccc 9320  

agcccatgcc ggccttccct ctggggagcg acttttccag aaggccggcc aggcgagagg 9380  

gtcttcctga cggcggagct gacctgcccg gcccaccagc tgcatgtcag ctccgagcca 9440  

ccgggtcccc gtccaaggct gctctgctaa gttaaagaca cccgaaagcg cttgactcag 9500  

gtccccggag tccctggcca gggccccagc ccctcgcttg ccctgcactg tgtggactct 9560  

ggggatgcag gtgtaagggg agtgtggctg ggcagcccct ggtcagccag ggtcacgcct 9620  

gtcctggggg ccccaccctg ctgcccgaca ccccccatgg gaggctgcgg gcggcagttg 9680  

ctgtctcaga gaggggagtg tgggggcttg ggcgctggcc tagccagggg cgaggtgggg 9740  

aggcggctgg tgcagaggag agctgggggc tgaggttggg gtgaaggctg cagccctcca 9800  

ggctgctggg ggtgcagatg gctgtgccgt gctgagattg gctctgtctg gaggggtcca 9860  

gtgtggggtg cctgagggca ctagggagag gtgctcctgc tgcaggagga cctgagggtc 9920  

agggcttgga gaggacaggg aacctgcggc cgtctcttct gctttggggc aggggctctg 9980  

gcccgggaga gggaacgggg acaggagcag aggacggtca tccaggcgca gcggggagct 10040 

gctccccagg ccacagcaga cagcactgct gagaggcagc ggccgcgcgg gtgacgcaaa 10100 

tggcaggccc tgggaatccc gccgcctccc acctagaatt gtcctacctc ccccacccca 10160 

aacaccagct tttcctggcg ccccaggccc agaacgtggg cccagagagc cttgctgggg 10220 

tctctggggc accttggcct tgctctgagg ctggaaggag aaggaccagg gtgcggcatc 10280 

actcggcctc agggacccct ctgccctgcc cagcactggc cccgacccgt gctcccgccg 10340 

tctgcccaga gcaggacctc aacctcctgg agggcacagg gagcggctga gtgggcacaa 10400 

atcctggcag gagaaaggcc caggctgagg ccaggcctgg gaaacatcca agcagtgagg 10460 

acacgcgtgt ttgacaactg ctcccctgaa taaa                             10494 


<210> 20
<211> 364        
<212> PRT
<213> Homo sapiens

<400> 20
Met Glu Pro Leu Phe Pro Ala Ser Thr Pro Ser Trp Asn Ala Ser Ser  
  1               5                  10                  15      
Pro Gly Ala Ala Ser Gly Gly Gly Asp Asn Arg Thr Leu Val Gly Pro  
             20                  25                  30          
Ala Pro Ser Ala Gly Ala Arg Ala Val Leu Val Pro Val Leu Tyr Leu  
         35                  40                  45              
Leu Val Cys Ala Ala Gly Leu Gly Gly Asn Thr Leu Val Ile Tyr Val  
     50                  55                  60                  
Val Leu Arg Phe Ala Lys Met Lys Thr Val Thr Asn Ile Tyr Ile Leu  
 65                  70                  75                  80  
Asn Leu Ala Val Ala Asp Val Leu Tyr Met Leu Gly Leu Pro Phe Leu  
                 85                  90                  95      
Ala Thr Gln Asn Ala Ala Ser Phe Trp Pro Phe Gly Pro Val Leu Cys  
            100                 105                 110          
Arg Leu Val Met Thr Leu Asp Gly Val Asn Gln Phe Thr Ser Val Phe  
        115                 120                 125              
Cys Leu Thr Val Met Ser Val Asp Arg Tyr Leu Ala Val Val His Pro  
    130                 135                 140                  
Leu Ser Ser Ala Arg Trp Arg Arg Pro Arg Val Ala Lys Leu Ala Ser  
145                 150                 155                 160  
Ala Ala Ala Trp Val Leu Ser Leu Cys Met Ser Leu Pro Leu Leu Val  
                165                 170                 175      
Phe Ala Asp Val Gln Glu Gly Gly Thr Cys Asn Ala Ser Trp Pro Glu  
            180                 185                 190          
Pro Val Gly Leu Trp Gly Ala Val Phe Ile Ile Tyr Thr Ala Val Leu  
        195                 200                 205              
Gly Phe Phe Ala Pro Leu Leu Val Ile Cys Leu Cys Tyr Leu Leu Ile  
    210                 215                 220                  
Val Val Lys Val Arg Ala Ala Gly Val Arg Val Gly Cys Val Arg Arg  
225                 230                 235                 240  
Arg Ser Glu Arg Lys Val Thr Arg Met Val Leu Val Val Val Leu Val  
                245                 250                 255      
Phe Ala Gly Cys Trp Leu Pro Phe Phe Thr Val Asn Ile Val Asn Leu  
            260                 265                 270          
Ala Val Ala Leu Pro Gln Glu Pro Ala Ser Ala Gly Leu Tyr Phe Phe  
        275                 280                 285              
Val Val Ile Leu Ser Tyr Ala Asn Ser Cys Ala Asn Pro Val Leu Tyr  
    290                 295                 300                  
Gly Phe Leu Ser Asp Asn Phe Arg Gln Ser Phe Gln Lys Val Leu Cys  
305                 310                 315                 320  
Leu Arg Lys Gly Ser Gly Ala Lys Asp Ala Asp Ala Thr Glu Pro Arg  
                325                 330                 335      
Pro Asp Arg Ile Arg Gln Gln Gln Glu Ala Thr Pro Pro Ala His Arg  
            340                 345                 350          
Ala Ala Ala Asn Gly Leu Met Gln Thr Ser Lys Leu                  
        355                 360                                  



<210> 21
<211> 1525
<212> DNA
<213> Mus musculus

<220> 
<221> CDS
<222> (241)..(1329)

<400> 21
ccgagccacc catcctcctg tccctgcagg tggcttcttc ttcctctcta gcttgttttc 60    

caaacaattt gcttaatgtg attcctggtc aagttgaaca tgactaaagg tgtttttact 120   

catcaccgtc tggcaggcgg gctccccacg acaggaggaa ggaatgcctg aatgtgccca 180   

ctagtgacac cctcttctct tgcagagata catgtgctct ggcatcctga acctcacagc 240   

atg gag ccc ctc tct ttg gct tcc aca cct agc tgg aat gcc tca gct   288   
Met Glu Pro Leu Ser Leu Ala Ser Thr Pro Ser Trp Asn Ala Ser Ala
  1               5                  10                  15    

gct tcc agc ggt agc cat aac tgg tca cta gtg gac ccg gtg tca ccc   336   
Ala Ser Ser Gly Ser His Asn Trp Ser Leu Val Asp Pro Val Ser Pro
             20                  25                  30        

atg gga gcc cgg gcg gta tta gtg cct gtg ctc tac ttg ttg gta tgc   384   
Met Gly Ala Arg Ala Val Leu Val Pro Val Leu Tyr Leu Leu Val Cys
         35                  40                  45            

acc gtg gga ctg ggt gga aac aca ctg gtc atc tat gtg gtg ttg cgg   432   
Thr Val Gly Leu Gly Gly Asn Thr Leu Val Ile Tyr Val Val Leu Arg
     50                  55                  60                

tat gcc aag atg aag aca gtt act aat gtg tac atc ctg aac ctg gcc   480   
Tyr Ala Lys Met Lys Thr Val Thr Asn Val Tyr Ile Leu Asn Leu Ala
 65                  70                  75                  80

gtg gct gac gtg ttg ttt atg ttg ggg ctt cct ttc ctg gca acg cag   528   
Val Ala Asp Val Leu Phe Met Leu Gly Leu Pro Phe Leu Ala Thr Gln
                 85                  90                  95    

aat gct gtc tcc tac tgg ccc ttt ggc tcc ttc ttg tgc cgc ctg gtc   576   
Asn Ala Val Ser Tyr Trp Pro Phe Gly Ser Phe Leu Cys Arg Leu Val
            100                 105                 110        

atg acg ctg gac ggt atc aac cag ttc acc agt atc ttc tgc ctg atg   624   
Met Thr Leu Asp Gly Ile Asn Gln Phe Thr Ser Ile Phe Cys Leu Met
        115                 120                 125            

gtc atg agt gtc gac cgc tac ctg gcc gtg gtc cac cct ctc cgc tca   672   
Val Met Ser Val Asp Arg Tyr Leu Ala Val Val His Pro Leu Arg Ser
    130                 135                 140                

gcc cgg tgg cgt cgc cca cgg gta gcc aag ctg gct agt gct gcc gtc   720   
Ala Arg Trp Arg Arg Pro Arg Val Ala Lys Leu Ala Ser Ala Ala Val
145                 150                 155                 160

tgg gtc ttc tcg ctg ctc atg tct ctg ccg ctc ttg gtc ttt gcg gat   768   
Trp Val Phe Ser Leu Leu Met Ser Leu Pro Leu Leu Val Phe Ala Asp
                165                 170                 175    

gtc cag gaa ggc tgg ggc acc tgc aac ctg agc tgg cca gag cct gtg   816   
Val Gln Glu Gly Trp Gly Thr Cys Asn Leu Ser Trp Pro Glu Pro Val
            180                 185                 190        

gga ctg tgg ggt gca gcc ttc atc act tac aca tct gtg ctg ggc ttc   864   
Gly Leu Trp Gly Ala Ala Phe Ile Thr Tyr Thr Ser Val Leu Gly Phe
        195                 200                 205            

ttt ggg ccc ctg ctg gtc atc tgc ttg tgc tat ttg ctc atc gta gtg   912   
Phe Gly Pro Leu Leu Val Ile Cys Leu Cys Tyr Leu Leu Ile Val Val
    210                 215                 220                

aag gtg aag gct gca ggt atg cgt gtg ggc tcc tca cgg cgg agg cgc   960   
Lys Val Lys Ala Ala Gly Met Arg Val Gly Ser Ser Arg Arg Arg Arg
225                 230                 235                 240

tca gaa cgc aag gtg act cgc atg gtg gtg gta gtg gtg ctg gtg ttc   1008  
Ser Glu Arg Lys Val Thr Arg Met Val Val Val Val Val Leu Val Phe
                245                 250                 255    

gtg ggc tgc tgg ctg cct ttc ttc atc gtc aac atc gtc aac ctg gcc   1056  
Val Gly Cys Trp Leu Pro Phe Phe Ile Val Asn Ile Val Asn Leu Ala
            260                 265                 270        

ttc acg cta ccc gag gag ccc acc tct gcc ggc ctc tac ttc ttt gtg   1104  
Phe Thr Leu Pro Glu Glu Pro Thr Ser Ala Gly Leu Tyr Phe Phe Val
        275                 280                 285            

gtg gtc ctg tct tat gcc aat agc tgt gcc aac ccc ctg ctg cta tgg   1152  
Val Val Leu Ser Tyr Ala Asn Ser Cys Ala Asn Pro Leu Leu Leu Trp
    290                 295                 300                

ctt ctc tct gat aac ttc cgc cag agt ttc cgg aag gct ctg tgc cta   1200  
Leu Leu Ser Asp Asn Phe Arg Gln Ser Phe Arg Lys Ala Leu Cys Leu
305                 310                 315                 320

cgt aga gga tac ggt gtg gag gat gca gat gcc ata gag cca cgg cca   1248  
Arg Arg Gly Tyr Gly Val Glu Asp Ala Asp Ala Ile Glu Pro Arg Pro
                325                 330                 335    

gac aag agt ggg cgg cca cag acc aca ctg ccc aca cgc agc tgt gag   1296  
Asp Lys Ser Gly Arg Pro Gln Thr Thr Leu Pro Thr Arg Ser Cys Glu
            340                 345                 350        

gcc aac ggg ctc atg cag acc agc agg ctt tga gtgtcccagt aacacctggg 1349  
Ala Asn Gly Leu Met Gln Thr Ser Arg Leu                          
        355                 360                                  

gggtcctgcg gggcctctgt ggtgttgtct tctgggatat gagagtttgc tgagatgcac 1409  

tcgcccccag gcctataagt tggactcctc ttggtggcag tgtgaagaca gctgtctgcg 1469  

gctaagccat gggtgactga tcatctctct caccaaaacg ttctgctaga ccaggg     1525  


<210> 22
<211> 362        
<212> PRT
<213> Mus musculus

<400> 22
Met Glu Pro Leu Ser Leu Ala Ser Thr Pro Ser Trp Asn Ala Ser Ala  
  1               5                  10                  15      
Ala Ser Ser Gly Ser His Asn Trp Ser Leu Val Asp Pro Val Ser Pro  
             20                  25                  30          
Met Gly Ala Arg Ala Val Leu Val Pro Val Leu Tyr Leu Leu Val Cys  
         35                  40                  45              
Thr Val Gly Leu Gly Gly Asn Thr Leu Val Ile Tyr Val Val Leu Arg  
     50                  55                  60                  
Tyr Ala Lys Met Lys Thr Val Thr Asn Val Tyr Ile Leu Asn Leu Ala  
 65                  70                  75                  80  
Val Ala Asp Val Leu Phe Met Leu Gly Leu Pro Phe Leu Ala Thr Gln  
                 85                  90                  95      
Asn Ala Val Ser Tyr Trp Pro Phe Gly Ser Phe Leu Cys Arg Leu Val  
            100                 105                 110          
Met Thr Leu Asp Gly Ile Asn Gln Phe Thr Ser Ile Phe Cys Leu Met  
        115                 120                 125              
Val Met Ser Val Asp Arg Tyr Leu Ala Val Val His Pro Leu Arg Ser  
    130                 135                 140                  
Ala Arg Trp Arg Arg Pro Arg Val Ala Lys Leu Ala Ser Ala Ala Val  
145                 150                 155                 160  
Trp Val Phe Ser Leu Leu Met Ser Leu Pro Leu Leu Val Phe Ala Asp  
                165                 170                 175      
Val Gln Glu Gly Trp Gly Thr Cys Asn Leu Ser Trp Pro Glu Pro Val  
            180                 185                 190          
Gly Leu Trp Gly Ala Ala Phe Ile Thr Tyr Thr Ser Val Leu Gly Phe  
        195                 200                 205              
Phe Gly Pro Leu Leu Val Ile Cys Leu Cys Tyr Leu Leu Ile Val Val  
    210                 215                 220                  
Lys Val Lys Ala Ala Gly Met Arg Val Gly Ser Ser Arg Arg Arg Arg  
225                 230                 235                 240  
Ser Glu Arg Lys Val Thr Arg Met Val Val Val Val Val Leu Val Phe  
                245                 250                 255      
Val Gly Cys Trp Leu Pro Phe Phe Ile Val Asn Ile Val Asn Leu Ala  
            260                 265                 270          
Phe Thr Leu Pro Glu Glu Pro Thr Ser Ala Gly Leu Tyr Phe Phe Val  
        275                 280                 285              
Val Val Leu Ser Tyr Ala Asn Ser Cys Ala Asn Pro Leu Leu Leu Trp  
    290                 295                 300                  
Leu Leu Ser Asp Asn Phe Arg Gln Ser Phe Arg Lys Ala Leu Cys Leu  
305                 310                 315                 320  
Arg Arg Gly Tyr Gly Val Glu Asp Ala Asp Ala Ile Glu Pro Arg Pro  
                325                 330                 335      
Asp Lys Ser Gly Arg Pro Gln Thr Thr Leu Pro Thr Arg Ser Cys Glu  
            340                 345                 350          
Ala Asn Gly Leu Met Gln Thr Ser Arg Leu                          
        355                 360                                  
