
                                SEQUENCE LISTING

<110> CLARK, Neil James
      HASKOVA, Zdenka
      HOPSON, Christopher B.
      LEE, jUDITHANN m.
      JOHANSON, Kyung Oh
      JONAK, Zdenka Ludmila
      TAYLOR, Alexander H.
      TRULLI, Stephen H.
      WHITE, John R.
      XUE, Yu
      

<120> NOVEL ANTIGEN BINDING PROTEINS
  

<130> PU64334

<150> 61/379,840          
<151> 2010-09-03  

<150> 61/440,460          
<151> 2011-02-08  

<160> 105

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 118
<212> PRT
<213> Mus musculus

<400> 1
Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asn Trp Val Lys Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Ile Asn Pro Asn Tyr Gly Thr Thr Val Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Val Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Met Thr Thr Ile Val Pro Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Leu Thr Val Ser Ser
        115             


<210> 2
<211> 5
<212> PRT
<213> Mus musculus

<400> 2
Asp Tyr Asn Met Asn
 1               5  


<210> 3
<211> 17
<212> PRT
<213> Mus musculus

<400> 3
Gly Ile Asn Pro Asn Tyr Gly Thr Thr Val Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 4
<211> 9
<212> PRT
<213> Mus musculus

<400> 4
Met Thr Thr Ile Val Pro Phe Asp Tyr
 1               5                  


<210> 5
<211> 107
<212> PRT
<213> Mus musculus

<400> 5
Asp Ile Gln Met Thr Gln Thr Thr Phe Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Phe Leu Thr Ile Arg Asn Leu Glu Glu
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Tyr Thr Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys
            100                 105         


<210> 6
<211> 11
<212> PRT
<213> Mus musculus

<400> 6
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn
 1               5                  10      


<210> 7
<211> 7
<212> PRT
<213> Mus musculus

<400> 7
Tyr Thr Ser Thr Leu His Ser
 1               5          


<210> 8
<211> 9
<212> PRT
<213> Mus musculus

<400> 8
Gln Gln Gly Tyr Thr Leu Pro Trp Thr
 1               5                  


<210> 9
<211> 120
<212> PRT
<213> Mus musculus

<400> 9
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Gly Met His Trp Leu Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Tyr Ile Thr Ser Gly Ser Ser Glu Ile Tyr Tyr Val Asp Thr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Cys
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr His Cys
                85                  90                  95      
Ala Arg Gly Tyr Gly Tyr Arg Glu Gly Tyr Phe Asp Val Trp Gly Thr
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser
        115                 120 


<210> 10
<211> 5
<212> PRT
<213> Mus musculus

<400> 10
Asp Tyr Gly Met His
 1               5  


<210> 11
<211> 17
<212> PRT
<213> Mus musculus

<400> 11
Tyr Ile Thr Ser Gly Ser Ser Glu Ile Tyr Tyr Val Asp Thr Val Lys
 1               5                  10                  15      
Gly
    


<210> 12
<211> 11
<212> PRT
<213> Mus musculus

<400> 12
Gly Tyr Gly Tyr Arg Glu Gly Tyr Phe Asp Val
 1               5                  10      


<210> 13
<211> 112
<212> PRT
<213> Mus musculus

<400> 13
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
                85                  90                  95      
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 14
<211> 16
<212> PRT
<213> Mus musculus

<400> 14
Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn
 1               5                  10                  15      


<210> 15
<211> 7
<212> PRT
<213> Mus musculus

<400> 15
Leu Val Ser Lys Leu Asp Ser
 1               5          


<210> 16
<211> 9
<212> PRT
<213> Mus musculus

<400> 16
Trp Gln Gly Thr His Phe Pro Gln Thr
 1               5                  


<210> 17
<211> 107
<212> PRT
<213> Mus musculus

<400> 17
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Val Tyr Ser Asn
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Arg Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Gly Ala Thr Arg Leu Pro Asp Gly Val Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Leu Phe Trp Gly Ile Pro Leu
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 18
<211> 11
<212> PRT
<213> Mus musculus

<400> 18
Arg Thr Ser Glu Asn Val Tyr Ser Asn Leu Ala
 1               5                  10      


<210> 19
<211> 7
<212> PRT
<213> Mus musculus

<400> 19
Gly Ala Thr Arg Leu Pro Asp
 1               5          


<210> 20
<211> 9
<212> PRT
<213> Mus musculus

<400> 20
Gln Leu Phe Trp Gly Ile Pro Leu Thr
 1               5                  


<210> 21
<211> 1342
<212> PRT
<213> Homo sapien

<400> 21
Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu
 1               5                  10                  15      
Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr
            20                  25                  30          
Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr
        35                  40                  45              
Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu
    50                  55                  60                  
Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile
65                  70                  75                  80  
Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr
                85                  90                  95      
Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp
            100                 105                 110         
Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser
        115                 120                 125             
His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser
    130                 135                 140                 
Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr
145                 150                 155                 160 
Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val
                165                 170                 175     
Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly
            180                 185                 190         
Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr
        195                 200                 205             
Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn
    210                 215                 220                 
Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp
225                 230                 235                 240 
Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val
                245                 250                 255     
Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu
            260                 265                 270         
Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala
        275                 280                 285             
Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala
    290                 295                 300                 
Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys
305                 310                 315                 320 
Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser
                325                 330                 335     
Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val
            340                 345                 350         
Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu
        355                 360                 365             
Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu
    370                 375                 380                 
Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln
385                 390                 395                 400 
Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr
                405                 410                 415     
Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile
            420                 425                 430         
Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu
        435                 440                 445             
Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr
    450                 455                 460                 
His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu
465                 470                 475                 480 
Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu
                485                 490                 495     
Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro
            500                 505                 510         
Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val
        515                 520                 525             
Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala
    530                 535                 540                 
His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu
545                 550                 555                 560 
Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys
                565                 570                 575     
Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly
            580                 585                 590         
Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn
        595                 600                 605             
Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro
    610                 615                 620                 
Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr
625                 630                 635                 640 
His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe
                645                 650                 655     
Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln
            660                 665                 670         
Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu
        675                 680                 685             
Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe
    690                 695                 700                 
Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe
705                 710                 715                 720 
Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys
                725                 730                 735     
Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser
            740                 745                 750         
Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His
        755                 760                 765             
Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln
    770                 775                 780                 
Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg
785                 790                 795                 800 
Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val
                805                 810                 815     
Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His
            820                 825                 830         
Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val
        835                 840                 845             
Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys
    850                 855                 860                 
Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu
865                 870                 875                 880 
Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser
                885                 890                 895     
Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr
            900                 905                 910         
Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu
        915                 920                 925             
Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met
    930                 935                 940                 
Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu
945                 950                 955                 960 
Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu
                965                 970                 975     
Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro
            980                 985                 990         
His Gly Leu Thr Asn Lys Lys Leu Glu Glu Val Glu Leu Glu Pro Glu
        995                 1000                1005            
Leu Asp Leu Asp Leu Asp Leu Glu Ala Glu Glu Asp Asn Leu Ala Thr
    1010                1015                1020                
Thr Thr Leu Gly Ser Ala Leu Ser Leu Pro Val Gly Thr Leu Asn Arg
1025                1030                1035               1040 
Pro Arg Gly Ser Gln Ser Leu Leu Ser Pro Ser Ser Gly Tyr Met Pro
                1045                1050                1055    
Met Asn Gln Gly Asn Leu Gly Glu Ser Cys Gln Glu Ser Ala Val Ser
            1060                1065                1070        
Gly Ser Ser Glu Arg Cys Pro Arg Pro Val Ser Leu His Pro Met Pro
        1075                1080                1085            
Arg Gly Cys Leu Ala Ser Glu Ser Ser Glu Gly His Val Thr Gly Ser
    1090                1095                1100                
Glu Ala Glu Leu Gln Glu Lys Val Ser Met Cys Arg Ser Arg Ser Arg
1105                1110                1115               1120 
Ser Arg Ser Pro Arg Pro Arg Gly Asp Ser Ala Tyr His Ser Gln Arg
                1125                1130                1135    
His Ser Leu Leu Thr Pro Val Thr Pro Leu Ser Pro Pro Gly Leu Glu
            1140                1145                1150        
Glu Glu Asp Val Asn Gly Tyr Val Met Pro Asp Thr His Leu Lys Gly
        1155                1160                1165            
Thr Pro Ser Ser Arg Glu Gly Thr Leu Ser Ser Val Gly Leu Ser Ser
    1170                1175                1180                
Val Leu Gly Thr Glu Glu Glu Asp Glu Asp Glu Glu Tyr Glu Tyr Met
1185                1190                1195               1200 
Asn Arg Arg Arg Arg His Ser Pro Pro His Pro Pro Arg Pro Ser Ser
                1205                1210                1215    
Leu Glu Glu Leu Gly Tyr Glu Tyr Met Asp Val Gly Ser Asp Leu Ser
            1220                1225                1230        
Ala Ser Leu Gly Ser Thr Gln Ser Cys Pro Leu His Pro Val Pro Ile
        1235                1240                1245            
Met Pro Thr Ala Gly Thr Thr Pro Asp Glu Asp Tyr Glu Tyr Met Asn
    1250                1255                1260                
Arg Gln Arg Asp Gly Gly Gly Pro Gly Gly Asp Tyr Ala Ala Met Gly
1265                1270                1275               1280 
Ala Cys Pro Ala Ser Glu Gln Gly Tyr Glu Glu Met Arg Ala Phe Gln
                1285                1290                1295    
Gly Pro Gly His Gln Ala Pro His Val His Tyr Ala Arg Leu Lys Thr
            1300                1305                1310        
Leu Arg Ser Leu Glu Ala Thr Asp Ser Ala Phe Asp Asn Pro Asp Tyr
        1315                1320                1325            
Trp His Ser Arg Leu Phe Pro Lys Ala Asn Ala Gln Arg Thr
    1330                1335                1340        


<210> 22
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 22
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Asn Tyr Gly Thr Thr Val Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Met Thr Thr Ile Val Pro Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Val Thr Val Ser Ser
        115             


<210> 23
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 23
Asp Tyr Asn Met Asn
 1               5  


<210> 24
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 24
Gly Ile Asn Pro Asn Tyr Gly Thr Thr Val Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 25
Met Thr Thr Ile Val Pro Phe Asp Tyr
 1               5                  


<210> 26
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 27
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 27
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn
 1               5                  10      


<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 28
Tyr Thr Ser Thr Leu His Ser
 1               5          


<210> 29
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 29
Gln Gln Gly Tyr Thr Leu Pro Trp Thr
 1               5                  


<210> 30
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 30
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Asp Pro Ser Asp Gly Tyr Ser His Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Gly Gly Leu Ala Gly Thr Leu Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 31
Ser Tyr Trp Met His
 1               5  


<210> 32
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 32
Val Ile Asp Pro Ser Asp Gly Tyr Ser His Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 33
Gly Leu Ala Gly Thr Leu Asp Tyr
 1               5              


<210> 34
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 34
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Gln Trp Phe Gln Gln Lys Pro Gly Lys Ala
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 35
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 35
Arg Ser Ser Gln Ser Ile Val His Ser Ser Gly Asn Thr Tyr Leu Gln
 1               5                  10                  15      


<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 36
Lys Val Ser Asn Arg Phe Ser
 1               5          


<210> 37
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 37
Phe Gln Gly Ser His Val Pro Trp Thr
 1               5                  


<210> 38
<211> 354
<212> DNA
<213> Mus musculus

<400> 38
gagttccagc tgcagcagag cggccccgag ctggtgaagc ccggcgccag cgtgaagatc 60
agctgcaagg ccagcggcta cagcttcacc gactacaaca tgaactgggt gaagcagaac 120
aacggcaaga gcctggagtg gatcggcggc atcaacccca actacggcac caccgtgtac 180
aaccagaagt tcaagggcaa ggccaccctg accgtggacc agagcagcag caccgcctac 240
atgcagctgg tgagcctgac cagcgaggac agcgccgtgt actactgcgc caggatgacc 300
accatcgtgc ccttcgacta ctggggccag ggcaccaccc tgaccgtgag cagc       354

<210> 39
<211> 321
<212> DNA
<213> Mus musculus

<400> 39
gacatccaga tgacccagac caccttcagc ctgagcgcca gcctgggcga cagggtgacc 60
atcagctgca gggccagcca ggacatcagc aactacctga actggtacca gcagaagccc 120
gacggcaccg tgaagctgct gatctactac accagcaccc tgcacagcgg cgtgcccagc 180
aggttcagcg gcagcggcag cggcaccgac tacttcctga ccatcaggaa cctggaggag 240
gaggacatcg ccacctactt ctgccagcag ggctacaccc tgccctggac cttcggcggc 300
ggcaccaagc tggacatcaa g                                           321

<210> 40
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequene designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 40
caggtccagc tcgtgcagtc tggggccgag gtgaagaaac ccggcgctag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc gactacaaca tgaactgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcggc atcaacccca actacggcac caccgtgtac 180
aaccagaagt tcaagggcaa ggtgaccctg accgtggaca ccagcatcag caccgcctac 240
atggaactga gcaggctgag gagcgacgat accgccgtgt actattgcgc caggatgacc 300
accatcgtgc ccttcgacta ctggggacag ggcaccactg tgacagtgtc aagccgu    357

<210> 41
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequene designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 41
gacatccaga tgacccagtc acccagcagc ctgagcgcca gcgtgggcga cagggtgacc 60
attacctgca gggccagcca ggacatcagc aactacctga actggtacca gcagaagccc 120
ggcaaggccc ccaagctgct gatctactac acctccaccc tgcacagcgg cgtgccctct 180
aggttctccg gcagcggcag cggcaccgac tacaccttca ccatcagcag cctgcagccc 240
gaggacatcg ccacctacta ttgccagcag ggctacaccc tcccctggac tttcggaggc 300
ggcaccaagg tggagatcaa g                                           321

<210> 42
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequene designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 42
caggtgcagc tggtgcagtc cggcgcagag gtgaagaagc ccggagcctc tgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc agctactgga tgcactgggt gaggcaggcc 120
cctggccagg gcctggagtg gatgggcgtg atcgacccca gcgacgggta cagccactac 180
aaccagaagt tcaagggcaa ggtcaccctg accgtggaca ccagcatcag caccgcctac 240
atggaactca gcaggctgag gagcgacgac accgccgtgt actattgcgc cggaggcctg 300
gctggcaccc tggattactg gggccagggc accacagtga ccgtgagcag c          351

<210> 43
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequene designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 43
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagggtgacc 60
attacctgca ggagcagcca gagcatcgtg cacagcagcg gcaacaccta cctgcagtgg 120
ttccagcaga aacccggcaa ggctcccaag ctgctgatct acaaggtgag caacaggttc 180
agcggcgtgc cctctcgctt ctcaggcagc ggctccggca ccgatttcac cctgaccatc 240
agctcactgc agcccgagga cttcgccgtc tactactgct tccagggaag ccacgtgccc 300
tggacttttg gccagggcac caagctcgag atcaagagg                        339

<210> 44
<211> 117
<212> PRT
<213> Mus musculus

<400> 44
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Asp Pro Ser Asp Gly Tyr Ser His Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Gly Gly Leu Ala Gly Thr Leu Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110         
Leu Thr Val Ser Ser
        115         


<210> 45
<211> 5
<212> PRT
<213> Mus musculus

<400> 45
Ser Tyr Trp Met His
 1               5  


<210> 46
<211> 17
<212> PRT
<213> Mus musculus

<400> 46
Val Ile Asp Pro Ser Asp Gly Tyr Ser His Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 47
<211> 8
<212> PRT
<213> Mus musculus

<400> 47
Gly Leu Ala Gly Thr Leu Asp Tyr
 1               5              


<210> 48
<211> 112
<212> PRT
<213> Mus musculus

<400> 48
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Gln Trp Phe Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Ser Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 49
<211> 16
<212> PRT
<213> Mus musculus

<400> 49
Arg Ser Ser Gln Ser Ile Val His Ser Ser Gly Asn Thr Tyr Leu Gln
 1               5                  10                  15      


<210> 50
<211> 7
<212> PRT
<213> Mus musculus

<400> 50
Lys Val Ser Asn Arg Phe Ser
 1               5          


<210> 51
<211> 9
<212> PRT
<213> Mus musculus

<400> 51
Phe Gln Gly Ser His Val Pro Trp Thr
 1               5                  


<210> 52
<211> 351
<212> DNA
<213> Mus musculus

<400> 52
caggtgcagc tgcagcagcc cggcgccgag ctggtgaggc ccggcaccag cgtgaagctg 60
agctgcaagg ccagcggcta caccttcacc agctactgga tgcactgggt gaagcagagg 120
cccggccagg gcctggagtg gatcggcgtg atcgacccca gcgacggcta cagccactac 180
aaccagaagt tcaagggcaa ggccaccctg accgtggaca ccagcagcag caccgcctac 240
atgcagctga gcagcctgac cagcgaggac agcgccgtgt actactgcgc cggcggcctg 300
gccggcaccc tggactactg gggccagggc accaccctga ccgtgagcag c          351

<210> 53
<211> 336
<212> DNA
<213> Mus musculus

<400> 53
gacgtgctga tgacccagac ccccctgagc ctgcccgtga gcctgggcga ccaggccagc 60
atcagctgca ggagcagcca gagcatcgtg cacagcagcg gcaacaccta cctgcagtgg 120
ttcctgcaga agcccggcca gagccccaag ctgctgatca gcaaggtgag caacaggttc 180
agcggcgtgc ccgacaggtt cagcggcagc ggcagcggca ccgacttcac cctgaggatc 240
agcagggtgg aggccgagga cctgggcctg tactactgct tccagggcag ccacgtgccc 300
tggaccttcg gcggcggcac caagctggag atcaag                           336

<210> 54
<211> 360
<212> DNA
<213> Mus musculus

<400> 54
gaggtgcagc tggtggagag cggcggcggc ctggtgaagc ccggcggcag cctgaagctg 60
agctgcgccg ccagcggctt caccttcagc gactacggca tgcactggct gaggcaggcc 120
cccgagaagg gcctggagtg ggtggcctac atcaccagcg gcagcagcga gatctactac 180
gtggacaccg tgaagggcag gttcaccatc agcagggaca acgccaagaa caccctgtgc 240
ctgcagatga ccagcctgag gagcgaggac accgccatgt accactgcgc caggggctac 300
ggctacaggg agggctactt cgacgtgtgg ggcaccggca ccaccgtgac cgtgagcagc 360


<210> 55
<211> 336
<212> DNA
<213> Mus musculus

<400> 55
gacgtggtga tgacccagac ccccctgacc ctgagcgtga ccatcggcca gcccgccagc 60
atcagctgca agagcagcca gagcctgctg gacagcgacg gcaagaccta cctgaactgg 120
ctgctgcaga ggcccggcca gagccccaag aggctgatct acctggtgag caagctggac 180
agcggcgtgc ccgacaggtt caccggcagc ggcagcggca ccgacttcac cctgaagatc 240
agcagggtgg aggccgagga cctgggcgtg tactactgct ggcagggcac ccacttcccc 300
cagaccttcg gcggcggcac caagctggag atcaag                           336

<210> 56
<211> 321
<212> DNA
<213> Mus musculus

<400> 56
gacatccaga tgacccagag ccccgccagc ctgagcgtga gcgtgggcga gaccgtgacc 60
atcacctgca ggaccagcga gaacgtgtac agcaacctgg cctggtacca gcagaagcag 120
ggcaggagcc cccagctgct ggtgtacggc gccaccaggc tgcccgacgg cgtgcccgcc 180
aggttcagcg gcagcggcag cggcacccag tacagcctga agatcaacag cctgcagagc 240
gaggacttcg gcacctacta ctgccagctg ttctggggca tccccctgac cttcggcgcc 300
ggcaccaagc tggagctgaa g                                           321

<210> 57
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 57
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Gln Trp Phe Gln Gln Lys Pro Gly Lys Ala
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg Arg
        


<210> 58
<211> 342
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 58
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagggtgacc 60
attacctgca ggagcagcca gagcatcgtg cacagcagcg gcaacaccta cctgcagtgg 120
ttccagcaga aacccggcaa ggctcccaag ctgctgatct acaaggtgag caacaggttc 180
agcggcgtgc cctctcgctt ctcaggcagc ggctccggca ccgatttcac cctgaccatc 240
agctcactgc agcccgagga cttcgccgtc tactactgct tccagggaag ccacgtgccc 300
tggacttttg gccagggcac caagctcgag atcaagaggc gt                    342

<210> 59
<211> 354
<212> DNA
<213> Mus musculus

<400> 59
gagttccagc tgcagcagtc tggacctgag ctggtgaagc ctggcgcttc agtgaagata 60
tcctgcaagg cctctggtta ctcatttact gactacaata tgaactgggt gaaacagaac 120
aatggaaaga gccttgagtg gattggagga attaatccta actatggtac tactgtttac 180
aatcagaagt tcaagggcaa ggccacattg actgtagacc aatcttccag cacagcctac 240
atgcagctcg ttagtctgac atctgaggac tctgcagtct attattgtgc aagaatgacc 300
acgatagttc cctttgacta ctggggccaa ggcaccactc tcacagtctc ctca       354

<210> 60
<211> 321
<212> DNA
<213> Mus musculus

<400> 60
gatatccaga tgacacagac tacattctcc ctgtctgcct ctctgggaga cagagtcacc 60
atcagttgca gggcaagtca ggacattagt aattatttaa actggtatca gcagaaacca 120
gatggaactg ttaaactcct gatctattac acatcaacat tacactcagg agtcccatca 180
agattcagtg gcagtgggtc tggaacagat tattttctca ccattaggaa cctggaggaa 240
gaagatattg ccacttactt ttgccaacag ggttatacgc ttccgtggac gttcggtgga 300
ggcaccaagt tggacatcaa a                                           321

<210> 61
<211> 351
<212> DNA
<213> Mus musculus

<400> 61
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctgggacttc agtgaagttg 60
tcctgcaagg cctctggcta caccttcacc agctactgga tgcactgggt aaagcagagg 120
cctggacaag gccttgagtg gatcggagtg attgatcctt ctgatggtta tagtcactac 180
aatcaaaagt tcaagggcaa ggccactttg actgtagaca catcctccag tacagcctac 240
atgcagctca gcagcctgac ctctgaggac tctgcggtct attactgtgc aggaggctta 300
gctgggacgc ttgactactg gggccagggc accactctca cagtctcctc a          351

<210> 62
<211> 336
<212> DNA
<213> Mus musculus

<400> 62
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc 60
atctcttgca gatctagtca gagcattgta catagttctg gaaacaccta tttacaatgg 120
ttcctgcaga aaccaggcca gtctccaaag ctcctgatct ccaaagtttc caaccgattt 180
tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaggatc 240
agcagagtgg aggctgagga tctgggactt tattactgct ttcaaggttc acatgttccg 300
tggacgttcg gtggaggcac caagttggaa atcaaa                           336

<210> 63
<211> 360
<212> DNA
<213> Mus musculus

<400> 63
gaggtgcagc tggtggagtc tgggggaggc ttagtgaagc ccggagggtc cctgaaactc 60
tcctgtgcag cctctggatt cactttcagt gactatggaa tgcactggct tcgtcaggct 120
ccagagaagg ggctggagtg ggttgcatac attactagtg gcagtagtga aatctactat 180
gtagacacag tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgtgc 240
ctgcaaatga ccagtctgag gtctgaggac acggccatgt atcactgtgc aaggggctac 300
ggttatagag aggggtactt cgatgtctgg ggcacaggga ccacggtcac cgtctcctca 360


<210> 64
<211> 336
<212> DNA
<213> Mus musculus

<400> 64
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc 60
atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg 120
ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac 180
tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc 240
agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct 300
cagacgttcg gtggaggcac caagctggaa atcaaa                           336

<210> 65
<211> 321
<212> DNA
<213> Mus musculus

<400> 65
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc 60
atcacatgtc gaacaagtga gaatgtttac agtaatttag catggtatca gcagaaacag 120
ggaagatctc ctcagctcct ggtctatggt gcaacaaggt taccagatgg tgtgccagca 180
aggttcagtg gcagtggatc aggcacacag tattccctca agatcaacag cctgcagtct 240
gaagattttg ggacttatta ctgtcaactt ttttggggta tcccgctcac gttcggtgct 300
gggaccaagc tggagctgaa a                                           321

<210> 66
<211> 624
<212> PRT
<213> Homo sapien

<400> 66
Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr Leu Asn Gly
 1               5                  10                  15      
Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr Leu Tyr Lys
            20                  25                  30          
Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu Ile Val Leu
        35                  40                  45              
Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile Arg Glu Val
    50                  55                  60                  
Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr Leu Pro Leu
65                  70                  75                  80  
Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp Gly Lys Phe
                85                  90                  95      
Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser His Ala Leu
            100                 105                 110         
Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser Gly Gly Val
        115                 120                 125             
Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr Ile Asp Trp
    130                 135                 140                 
Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val Lys Asp Asn
145                 150                 155                 160 
Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly Arg Cys Trp
                165                 170                 175     
Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr Ile Cys Ala
            180                 185                 190         
Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn Gln Cys Cys
        195                 200                 205             
His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp Thr Asp Cys
    210                 215                 220                 
Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val Pro Arg Cys
225                 230                 235                 240 
Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu Glu Pro Asn
                245                 250                 255     
Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala Ser Cys Pro
            260                 265                 270         
His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala Cys Pro Pro
        275                 280                 285             
Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys Glu Pro Cys
    290                 295                 300                 
Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser Gly Ser Arg
305                 310                 315                 320 
Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val Asn Cys Thr
                325                 330                 335     
Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu Asn Gly Asp
            340                 345                 350         
Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu Asn Val Phe
        355                 360                 365             
Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln Ser Trp Pro
    370                 375                 380                 
Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr Thr Ile Gly
385                 390                 395                 400 
Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile Met Lys Asn
                405                 410                 415     
Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu Ile Ser Ala
            420                 425                 430         
Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr His His Ser
        435                 440                 445             
Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu Arg Leu Asp
    450                 455                 460                 
Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu Gly Lys Val
465                 470                 475                 480 
Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro Gly Pro Gly
                485                 490                 495     
Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val Cys Val Thr
            500                 505                 510         
His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala His Glu Ala
        515                 520                 525             
Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu Gly Thr Ala
    530                 535                 540                 
Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys Ala His Phe
545                 550                 555                 560 
Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly Val Leu Gly
                565                 570                 575     
Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn Glu Cys Arg
            580                 585                 590         
Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro Glu Leu Gln
        595                 600                 605             
Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr His Leu Thr
    610                 615                 620                 


<210> 67
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 67
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Asp Pro Ser Asp Gly Tyr Ser His Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Leu Ala Gly Thr Leu Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 68
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 68
caggtgcagc tggtgcagtc cggcgcagag gtgaagaagc ccggagcctc tgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc agctactgga tgcactgggt gaggcaggcc 120
cctggccagg gcctggagtg gatgggcgtg atcgacccca gcgacgggta cagccactac 180
aaccagaagt tcaagggcag ggtcaccatg accagggaca ccagcatcag caccgcctac 240
atggaactca gcaggctgag gagcgacgac accgccgtgt actattgcgc caggggcctg 300
gctggcaccc tggattactg gggccagggc accacagtga ccgtgagcag c          351

<210> 69
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 69
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Asp Pro Ser Asp Gly Tyr Ser His Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Leu Ala Gly Thr Leu Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 70
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 70
caggtgcagc tggtgcagtc cggcgcagag gtgaagaagc ccggagcctc tgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc agctactgga tgcactgggt gaggcaggcc 120
cctggccagg gcctggagtg gatgggcgtg atcgacccca gcgacgggta cagccactac 180
aaccagaagt tcaagggcag ggtcaccatg accgtggaca ccagcatcag caccgcctac 240
atggaactca gcaggctgag gagcgacgac accgccgtgt actattgcgc caggggcctg 300
gctggcaccc tggattactg gggccagggc accacagtga ccgtgagcag c          351

<210> 71
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 71
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Asp Pro Ser Asp Gly Tyr Ser His Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Gly Gly Leu Ala Gly Thr Leu Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 72
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 72
caggtgcagc tggtgcagtc cggcgcagag gtgaagaagc ccggagcctc tgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc agctactgga tgcactgggt gaggcaggcc 120
cctggccagg gcctggagtg gatgggcgtg atcgacccca gcgacgggta cagccactac 180
aaccagaagt tcaagggcag ggtcaccatg accagggaca ccagcatcag caccgcctac 240
atggaactca gcaggctgag gagcgacgac accgccgtgt actattgcgc cggaggcctg 300
gctggcaccc tggattactg gggccagggc accacagtga ccgtgagcag c          351

<210> 73
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 73
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Asp Pro Ser Asp Gly Tyr Ser His Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Leu Ala Gly Thr Leu Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 74
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 74
caggtgcagc tggtgcagtc cggcgcagag gtgaagaagc ccggagcctc tgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc agctactgga tgcactgggt gaggcaggcc 120
cctggccagg gcctggagtg gatgggcgtg atcgacccca gcgacgggta cagccactac 180
aaccagaagt tcaagggcaa ggtcaccatg accagggaca ccagcatcag caccgcctac 240
atggaactca gcaggctgag gagcgacgac accgccgtgt actattgcgc caggggcctg 300
gctggcaccc tggattactg gggccagggc accacagtga ccgtgagcag c          351

<210> 75
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 75
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 76
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 76
gacatccaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagggtgacc 60
attacctgca ggagcagcca gagcatcgtg cacagcagcg gcaacaccta cctgcagtgg 120
taccagcaga aacccggcaa ggctcccaag ctgctgatct acaaggtgag caacaggttc 180
agcggcgtgc cctctcgctt ctcaggcagc ggctccggca ccgatttcac cctgaccatc 240
agctcactgc agcccgagga cttcgccgtc tactactgct tccagggaag ccacgtgccc 300
tggacttttg gccagggcac caagctcgag atcaagagg                        339

<210> 77
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 77
Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 78
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 78
gacgtgcaga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagggtgacc 60
attacctgca ggagcagcca gagcatcgtg cacagcagcg gcaacaccta cctgcagtgg 120
taccagcaga aacccggcaa ggctcccaag ctgctgatct acaaggtgag caacaggttc 180
agcggcgtgc cctctcgctt ctcaggcagc ggctccggca ccgatttcac cctgaccatc 240
agctcactgc agcccgagga cttcgccgtc tactactgct tccagggaag ccacgtgccc 300
tggacttttg gccagggcac caagctcgag atcaagagg                        339

<210> 79
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 79
Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 80
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 80
gacatcctga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagggtgacc 60
attacctgca ggagcagcca gagcatcgtg cacagcagcg gcaacaccta cctgcagtgg 120
taccagcaga aacccggcaa ggctcccaag ctgctgatct acaaggtgag caacaggttc 180
agcggcgtgc cctctcgctt ctcaggcagc ggctccggca ccgatttcac cctgaccatc 240
agctcactgc agcccgagga cttcgccgtc tactactgct tccagggaag ccacgtgccc 300
tggacttttg gccagggcac caagctcgag atcaagagg                        339

<210> 81
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 81
Asp Val Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Gln Trp Phe Gln Gln Lys Pro Gly Lys Ala
        35                  40                  45              
Pro Lys Leu Leu Ile Ser Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 82
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 82
gacgtgctga tgacccagag cccctctagc ctgagcgcca gcgtgggcga cagggtgacc 60
attacctgca ggagcagcca gagcatcgtg cacagcagcg gcaacaccta cctgcagtgg 120
ttccagcaga aacccggcaa ggctcccaag ctgctgatca gcaaggtgag caacaggttc 180
agcggcgtgc cctctcgctt ctcaggcagc ggctccggca ccgatttcac cctgaccatc 240
agctcactgc agcccgagga cttcgccgtc tactactgct tccagggaag ccacgtgccc 300
tggacttttg gccagggcac caagctcgag atcaagagg                        339

<210> 83
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 83
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Gln Trp Phe Gln Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 84
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 84
gacgtggtga tgacacagag ccctctgagc ctgcctgtga ccctgggcca gcccgccagc 60
attagctgca ggagcagcca gtccatcgtg cacagcagcg gcaacaccta cctgcagtgg 120
ttccagcaga ggcccggcca gagccccagg aggctgatct acaaggtgag caacaggttc 180
agcggcgtgc ccgacagatt cagcggctca ggcagcggca ccgacttcac cctcaagatc 240
agcagggtgg aggccgagga cgtgggcgtc tactactgct tccaggggag ccacgtgccc 300
tggacctttg gacagggcac caagctggag atcaagagg                        339

<210> 85
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 85
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Gln Trp Phe Gln Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Arg Arg Leu Ile Ser Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 86
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 86
gacgtggtga tgacacagag ccctctgagc ctgcctgtga ccctgggcca gcccgccagc 60
attagctgca ggagcagcca gtccatcgtg cacagcagcg gcaacaccta cctgcagtgg 120
ttccagcaga ggcccggcca gagccccagg aggctgatca gcaaggtgag caacaggttc 180
agcggcgtgc ccgacagatt cagcggctca ggcagcggca ccgacttcac cctcaagatc 240
agcagggtgg aggccgagga cgtgggcgtc tactactgct tccaggggag ccacgtgccc 300
tggacctttg gacagggcac caagctcgag atcaagagg                        339

<210> 87
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 87
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Gln Trp Phe Gln Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Ser Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 88
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 88
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Ser Gly Asn Thr Tyr Leu Gln Trp Phe Gln Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Ser Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 89
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 89
gacgtggtga tgacacagag ccctctgagc ctgcctgtga ccctgggcca gcccgccagc 60
attagctgca ggagcagcca gtccatcgtg cacagcagcg gcaacaccta cctgcagtgg 120
ttccagcaga ggcccggcca gagccccaag ctgctgatca gcaaggtgag caacaggttc 180
agcggcgtgc ccgacagatt cagcggctca ggcagcggca ccgacttcac cctcaagatc 240
agcagggtgg aggccgagga cgtgggcgtc tactactgct tccaggggag ccacgtgccc 300
tggacctttg gacagggcac caagctcgag atcaagagg                        339

<210> 90
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 90
Gln Phe Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Ile Asn Pro Asn Tyr Gly Thr Thr Val Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Met Thr Thr Ile Val Pro Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Val Thr Val Ser Ser
        115             


<210> 91
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 91
cagttccagc tggtgcagag cggagccgag gtgaagaagc ccggagccag cgtcaaagtg 60
agctgcaagg cctccggcta cagcttcacc gactacaaca tgaactgggt gaagcaggcc 120
cccgggcagg gcctggagtg gatcggcggc atcaatccca actacggcac caccgtgtac 180
aaccagaagt tcaagggcaa ggccaccctg accgtggacc agagcatcag caccgcctac 240
atggaactca gcaggctgag gagcgacgat accgccgtgt actactgcgc taggatgacc 300
accatcgtgc ccttcgacta ttggggccag ggcacaaccg tgactgtgag cagc       354

<210> 92
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 92
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Gly Ile Asn Pro Asn Tyr Gly Thr Thr Val Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Met Thr Thr Ile Val Pro Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Val Thr Val Ser Ser
        115             


<210> 93
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 93
caggtgcagc tcgtgcagag cggagccgag gtgaaaaagc ccggcgctag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc gactacaaca tgaactgggt gaagcaggca 120
cccggccagg gcctggagtg gatcggcggc atcaacccca actacggcac taccgtctac 180
aaccagaagt tcaagggcaa ggccaccctg accgtggatc agagcatcag caccgcctac 240
atggaactgt ctaggctgag gagcgacgac accgccgtgt actattgcgc caggatgacc 300
accatcgtgc ccttcgacta ctggggccag ggaaccacag tcaccgtgag cagc       354

<210> 94
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 94
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Asn Tyr Gly Thr Thr Val Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Met Thr Thr Ile Val Pro Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Val Thr Val Ser Ser
        115             


<210> 95
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 95
caggtgcagc tggtccagag cggagccgag gtgaaaaagc ccggcgcaag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc gactacaaca tgaactgggt gaggcaggcc 120
cccggccagg gcctcgagtg gatgggaggc atcaacccca actacggcac caccgtgtac 180
aaccagaagt tcaagggcaa ggccaccctg accgtggacc agagcatcag caccgcctac 240
atggaactga gcaggctgag gagcgacgac accgccgtgt actattgcgc caggatgacc 300
accatcgtgc ccttcgacta ctggggccag ggcacaaccg tgaccgtgtc tagc       354

<210> 96
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 96
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 97
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 97
gacatccaga tgacccagag ccctagcagc ctgagcgcct cagtgggcga tagggtgacc 60
atcacctgca gggccagcca ggacatcagc aactacctga actggtacca gcagaagccc 120
gggaaggccc ccaagctgct gatctactac acctccaccc tgcacagcgg cgtgccctca 180
aggttctccg gcagcggcag cggcaccgac tacactctga ccatcagcag cctccagccc 240
gaggacttcg ccacctacta ctgccagcag ggctataccc tgccctggac cttcggccag 300
ggcaccaagc tggagattaa gagg                                        324

<210> 98
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 98
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 99
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 99
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga tagggtgacc 60
attacctgca gggccagcca ggacatcagc aactacctga actggtacca gcagaagccc 120
ggcaaggccc ccaagctgct gatctactac acctccactc tgcacagcgg cgtgccctct 180
aggttctccg gctcaggcag cggaaccgac ttcaccctga ccatcagcag cctccagccc 240
gaggacttcg ccacctacta ctgccagcag ggctataccc tgccttggac cttcggccag 300
ggcaccaaac tggagatcaa gagg                                        324

<210> 100
<211> 466
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 100
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        35                  40                  45              
Thr Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60                  
Glu Trp Met Gly Val Ile Asp Pro Ser Asp Gly Tyr Ser His Tyr Asn
65                  70                  75                  80  
Gln Lys Phe Lys Gly Lys Val Thr Leu Thr Val Asp Thr Ser Ile Ser
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Gly Gly Leu Ala Gly Thr Leu Asp Tyr Trp Gly Gln
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
    130                 135                 140                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
145                 150                 155                 160 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
                165                 170                 175     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
            180                 185                 190         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
        195                 200                 205             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
    210                 215                 220                 
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
225                 230                 235                 240 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
            260                 265                 270         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
        275                 280                 285             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
            340                 345                 350         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
        355                 360                 365             
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
385                 390                 395                 400 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
            420                 425                 430         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
    450                 455                 460                 
Gly Lys
465     


<210> 101
<211> 1398
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 101
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggtgt gcacagccag 60
gtgcagctgg tgcagtccgg cgcagaggtg aagaagcccg gagcctctgt gaaggtgagc 120
tgcaaggcca gcggctacac cttcaccagc tactggatgc actgggtgag gcaggcccct 180
ggccagggcc tggagtggat gggcgtgatc gaccccagcg acgggtacag ccactacaac 240
cagaagttca agggcaaggt caccctgacc gtggacacca gcatcagcac cgcctacatg 300
gaactcagca ggctgaggag cgacgacacc gccgtgtact attgcgccgg aggcctggct 360
ggcaccctgg attactgggg ccagggcacc acagtgaccg tgagcagcgc cagcaccaag 420
ggccccagcg tgttccccct ggcgcccagc agcaagagca ccagcggcgg cacagccgcc 480
ctgggctgcc tggtgaagga ctacttcccc gagccagtga ccgtgtcctg gaacagcgga 540
gccctgacca gcggcgtgca caccttccca gctgtcctgc agagcagcgg cctgtacagc 600
ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgtaac 660
gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgtgac 720
aagacccaca cctgcccccc ctgccctgcc cccgagctgc tgggaggccc cagcgtgttc 780
ctgttccccc ccaagcctaa ggacaccctg atgatcagca gaacccccga ggtgacctgt 840
gtggtggtgg atgtgagcca cgaggaccct gaggtgaagt tcaactggta cgtggacggc 900
gtggaggtgc acaatgccaa gaccaagccc agggaggagc agtacaacag cacctaccgg 960
gtggtgtccg tgctgaccgt gctgcaccag gattggctga acggcaagga gtacaagtgt 1020
aaggtgtcca acaaggccct gcctgcccct atcgagaaaa ccatcagcaa ggccaagggc 1080
cagcccagag agccccaggt gtacaccctg ccccctagca gagatgagct gaccaagaac 1140
caggtgtccc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg 1200
gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgat 1260
ggcagcttct tcctgtacag caagctgacc gtggacaaga gcagatggca gcagggcaac 1320
gtgttcagct gctccgtgat gcacgaggcc ctgcacaatc actacaccca gaagagcctg 1380
agcctgtccc ctggcaag                                               1398

<210> 102
<211> 466
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 102
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        35                  40                  45              
Thr Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60                  
Glu Trp Met Gly Val Ile Asp Pro Ser Asp Gly Tyr Ser His Tyr Asn
65                  70                  75                  80  
Gln Lys Phe Lys Gly Lys Val Thr Leu Thr Val Asp Thr Ser Ile Ser
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Gly Gly Leu Ala Gly Thr Leu Asp Tyr Trp Gly Gln
        115                 120                 125             
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
    130                 135                 140                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
145                 150                 155                 160 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
                165                 170                 175     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
            180                 185                 190         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
        195                 200                 205             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
    210                 215                 220                 
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
225                 230                 235                 240 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
            260                 265                 270         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
        275                 280                 285             
Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
            340                 345                 350         
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
        355                 360                 365             
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
385                 390                 395                 400 
Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
            420                 425                 430         
Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
    450                 455                 460                 
Gly Lys
465     


<210> 103
<211> 1398
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 103
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggtgt gcacagccag 60
gtgcagctgg tgcagtccgg cgcagaggtg aagaagcccg gagcctctgt gaaggtgagc 120
tgcaaggcca gcggctacac cttcaccagc tactggatgc actgggtgag gcaggcccct 180
ggccagggcc tggagtggat gggcgtgatc gaccccagcg acgggtacag ccactacaac 240
cagaagttca agggcaaggt caccctgacc gtggacacca gcatcagcac cgcctacatg 300
gaactcagca ggctgaggag cgacgacacc gccgtgtact attgcgccgg aggcctggct 360
ggcaccctgg attactgggg ccagggcacc acagtgaccg tgagcagcgc cagcaccaag 420
ggcccaagcg tgtttcccct ggcccccagc agcaagtcta ccagcggcgg cacagccgcc 480
ctgggctgcc tggtcaaaga ctacttcccc gagcccgtca ccgtgagctg gaatagcggc 540
gcactgacca gcggcgtgca cacctttccc gccgtgctgc agagctcagg cctgtatagc 600
ctgagcagcg tggtgaccgt gccttctagc agcctgggca cccagaccta catctgcaac 660
gtcaaccaca agcccagcaa caccaaggtg gacaagaaag tggagcccaa gagctgcgac 720
aagacccaca cctgcccccc ctgtccagct ccggagctgc tgggcggccc cagcgtgttc 780
ctcttccccc ccaagcccaa ggacaccctg atgatctcta gaacccccga ggtgacctgc 840
gtggtggtgg acgtcagcca cgaagacccc gaggtgcagt tcaagtggta cgtggacggg 900
gtggaggtgc acaacgccaa gactaagccc agggaggagc agttcaactc caccttcagg 960
gtggtgagcg tcctgaccgt gctgcatcag gactggctga acggcaagga gtacaagtgc 1020
aaggtgagca acaaggccct gcccgccccc atcgagaaga ccatcagcaa aaccaagggc 1080
cagcctaggg aaccccaggt gtacaccctg cccccctcca gggaggagat gaccaagaac 1140
caggtgagcc tcacctgcct ggtgaagggc ttctacccca gcgacattgc cgtggagtgg 1200
gagtcaagcg gccagcccga gaacaactac aagaccaccc cccccatgct cgatagcgac 1260
ggcagcttct tcctgtacag caagctgacc gtggacaaga gccggtggca gcagggcaac 1320
atcttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg 1380
agcctgagcc ccggaaag                                               1398

<210> 104
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody amino acid sequence designed in
      silico and made using molecular biology synthetic
      techniques.

<400> 104
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile
        35                  40                  45              
Val His Ser Ser Gly Asn Thr Tyr Leu Gln Trp Phe Gln Gln Lys Pro
    50                  55                  60                  
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser
65                  70                  75                  80  
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
                85                  90                  95      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys
            100                 105                 110         
Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu
        115                 120                 125             
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
    130                 135                 140                 
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
                165                 170                 175     
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
        195                 200                 205             
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
    210                 215                 220                 
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235             


<210> 105
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody nucleic acid sequence designed
      in silico and made using molecular biology
      synthetic techniques.

<400> 105
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt ccactccgac 60
atccagatga cccagagccc ctctagcctg agcgccagcg tgggcgacag ggtgaccatt 120
acctgcagga gcagccagag catcgtgcac agcagcggca acacctacct gcagtggttc 180
cagcagaaac ccggcaaggc tcccaagctg ctgatctaca aggtgagcaa caggttcagc 240
ggcgtgccct ctcgcttctc aggcagcggc tccggcaccg atttcaccct gaccatcagc 300
tcactgcagc ccgaggactt cgccgtctac tactgcttcc agggaagcca cgtgccctgg 360
acttttggcc agggcaccaa gctcgagatc aagcgtacgg tggccgcccc cagcgtgttc 420
atcttccccc ccagcgatga gcagctgaag agcggcaccg ccagcgtggt gtgtctgctg 480
aacaacttct acccccggga ggccaaggtg cagtggaagg tggacaatgc cctgcagagc 540
ggcaacagcc aggagagcgt gaccgagcag gacagcaagg actccaccta cagcctgagc 600
agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgtgaggtg 660
acccaccagg gcctgtccag ccccgtgacc aagagcttca accggggcga gtgc       714
