                         SEQUENCE LISTING

<110>  University of Connecticut
       Goldschneider, Irving
 
<120>  IN VIVO ANTI-TUMOR ACTIVITY OF A RECOMBINANT IL-7/HGF  HYBRID 
       CYTOKINE AND ASSOCIATED METHODS OF USE

<130>  98121.00197

<140>  TBD
<141>  2011-09-01

<150>  61/379,101
<151>  2010-09-01

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  HGF Primer 5' flanking region

<400>  1
cagtctgctc gaactgca                                                     18


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  HGF Primer

<400>  2
tggcctcttc tatggcta                                                     18


<210>  3
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  PEPTIDE
<222>  (1)..(17)

<400>  3

Val Val Asn Gly Ile Pro Thr Gln Thr Asn Ile Gly Trp Met Val Ser 
1               5                   10                  15      


Leu 
    


<210>  4
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Mouse HGF-Beta chain

<400>  4

Val Val Asn Gly Ile Pro Thr Gln Thr Thr Val Gly Trp Met Val Ser 
1               5                   10                  15      


Leu 
    


<210>  5
<211>  728
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(728)
<223>  ACCESSION   BAA14348 (human HGF protein)

<400>  5

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             


<210>  6
<211>  728
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(728)
<223>  ACCESSION   NP_034557 XP_131908 (Mouse HGF Protein)

<400>  6

Met Met Trp Gly Thr Lys Leu Leu Pro Val Leu Leu Leu Gln His Val 
1               5                   10                  15      


Leu Leu His Leu Leu Leu Leu His Val Ala Ile Pro Tyr Ala Glu Gly 
            20                  25                  30          


Gln Lys Lys Arg Arg Asn Thr Leu His Glu Phe Lys Lys Ser Ala Lys 
        35                  40                  45              


Thr Thr Leu Thr Lys Glu Asp Pro Leu Leu Lys Ile Lys Thr Lys Lys 
    50                  55                  60                  


Val Asn Ser Ala Asp Glu Cys Ala Asn Arg Cys Ile Arg Asn Arg Gly 
65                  70                  75                  80  


Phe Thr Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ser Arg Lys Arg 
                85                  90                  95      


Cys Tyr Trp Tyr Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Gly 
            100                 105                 110         


Phe Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 
        115                 120                 125             


Cys Ile Ile Gly Lys Gly Gly Ser Tyr Lys Gly Thr Val Ser Ile Thr 
    130                 135                 140                 


Lys Ser Gly Ile Lys Cys Gln Pro Trp Asn Ser Met Ile Pro His Glu 
145                 150                 155                 160 


His Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn 
                165                 170                 175     


Tyr Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr 
            180                 185                 190         


Ser Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser 
        195                 200                 205             


Glu Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Pro Met 
    210                 215                 220                 


Asp His Thr Glu Ser Gly Lys Thr Cys Gln Arg Trp Asp Gln Gln Thr 
225                 230                 235                 240 


Pro His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe 
                245                 250                 255     


Asp Asp Asn Tyr Cys Arg Asn Pro Asp Gly Lys Pro Arg Pro Trp Cys 
            260                 265                 270         


Tyr Thr Leu Asp Pro Asp Thr Thr Trp Glu Tyr Cys Ala Ile Lys Thr 
        275                 280                 285             


Cys Ala His Ser Ala Val Asn Glu Thr Asp Val Pro Met Glu Thr Thr 
    290                 295                 300                 


Glu Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Ser Asn Thr 
305                 310                 315                 320 


Ile Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His 
                325                 330                 335     


Lys His Asp Ile Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu 
            340                 345                 350         


Asn Tyr Cys Arg Asn Pro Asp Gly Ala Glu Ser Pro Trp Cys Phe Thr 
        355                 360                 365             


Thr Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Lys Cys 
    370                 375                 380                 


Asp Val Ser Ser Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr 
385                 390                 395                 400 


Met Gly Asn Leu Ser Lys Thr Arg Ser Gly Leu Thr Cys Ser Met Trp 
                405                 410                 415     


Asp Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp 
            420                 425                 430         


Ala Ser Lys Leu Asn Lys Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala 
        435                 440                 445             


His Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr 
    450                 455                 460                 


Cys Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn 
465                 470                 475                 480 


Leu Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val 
                485                 490                 495     


Val Asn Gly Ile Pro Thr Gln Thr Thr Val Gly Trp Met Val Ser Leu 
            500                 505                 510         


Lys Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser 
        515                 520                 525             


Trp Val Ile Thr Ala Arg Gln Cys Phe Pro Ala Arg Asn Lys Asp Leu 
    530                 535                 540                 


Lys Asp Tyr Glu Ala Trp Leu Gly Ile His Asp Val His Glu Arg Gly 
545                 550                 555                 560 


Glu Glu Lys Arg Lys Gln Ile Leu Asn Ile Ser Gln Leu Val Tyr Gly 
                565                 570                 575     


Pro Glu Gly Ser Asp Leu Val Leu Leu Lys Leu Ala Arg Pro Ala Ile 
            580                 585                 590         


Leu Asp Asn Phe Val Ser Thr Ile Asp Leu Pro Ser Tyr Gly Cys Thr 
        595                 600                 605             


Ile Pro Glu Lys Thr Thr Cys Ser Ile Tyr Gly Trp Gly Tyr Thr Gly 
    610                 615                 620                 


Leu Ile Asn Ala Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met 
625                 630                 635                 640 


Gly Asn Glu Lys Cys Ser Gln His His Gln Gly Lys Val Thr Leu Asn 
                645                 650                 655     


Glu Ser Glu Leu Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys 
            660                 665                 670         


Glu Gly Asp Tyr Gly Gly Pro Leu Ile Cys Glu Gln His Lys Met Arg 
        675                 680                 685             


Met Val Leu Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn 
    690                 695                 700                 


Arg Pro Val Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His 
705                 710                 715                 720 


Lys Val Ile Leu Thr Tyr Lys Leu 
                725             


<210>  7
<211>  177
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(177)
<223>  ACCESSION   NP_000871 (human IL-7 protein)

<400>  7

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  8
<211>  154
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(154)
<223>  ACCESSION   NP_032397 (Mouse IL-7 Protein)

<400>  8

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Thr Ser Ser Glu Cys His Ile Lys Asp Lys 
            20                  25                  30          


Glu Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu 
        35                  40                  45              


Asp Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn 
    50                  55                  60                  


Phe Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu 
65                  70                  75                  80  


Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser 
                85                  90                  95      


Glu Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr 
            100                 105                 110         


Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys 
        115                 120                 125             


Lys Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr 
    130                 135                 140                 


Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile 
145                 150                 


<210>  9
<211>  2187
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2187)
<223>  ACCESSION   NM_000601 (Human HGF cDNA)

<400>  9
atgtgggtga ccaaactcct gccagccctg ctgctgcagc atgtcctcct gcatctcctc       60

ctgctcccca tcgccatccc ctatgcagag ggacaaagga aaagaagaaa tacaattcat      120

gaattcaaaa aatcagcaaa gactacccta atcaaaatag atccagcact gaagataaaa      180

accaaaaaag tgaatactgc agaccaatgt gctaatagat gtactaggaa taaaggactt      240

ccattcactt gcaaggcttt tgtttttgat aaagcaagaa aacaatgcct ctggttcccc      300

ttcaatagca tgtcaagtgg agtgaaaaaa gaatttggcc atgaatttga cctctatgaa      360

aacaaagact acattagaaa ctgcatcatt ggtaaaggac gcagctacaa gggaacagta      420

tctatcacta agagtggcat caaatgtcag ccctggagtt ccatgatacc acacgaacac      480

agctttttgc cttcgagcta tcggggtaaa gacctacagg aaaactactg tcgaaatcct      540

cgaggggaag aagggggacc ctggtgtttc acaagcaatc cagaggtacg ctacgaagtc      600

tgtgacattc ctcagtgttc agaagttgaa tgcatgacct gcaatgggga gagttatcga      660

ggtctcatgg atcatacaga atcaggcaag atttgtcagc gctgggatca tcagacacca      720

caccggcaca aattcttgcc tgaaagatat cccgacaagg gctttgatga taattattgc      780

cgcaatcccg atggccagcc gaggccatgg tgctatactc ttgaccctca cacccgctgg      840

gagtactgtg caattaaaac atgcgctgac aatactatga atgacactga tgttcctttg      900

gaaacaactg aatgcatcca aggtcaagga gaaggctaca ggggcactgt caataccatt      960

tggaatggaa ttccatgtca gcgttgggat tctcagtatc ctcacgagca tgacatgact     1020

cctgaaaatt tcaagtgcaa ggacctacga gaaaattact gccgaaatcc agatgggtct     1080

gaatcaccct ggtgttttac cactgatcca aacatccgag ttggctactg ctcccaaatt     1140

ccaaactgtg atatgtcaca tggacaagat tgttatcgtg ggaatggcaa aaattatatg     1200

ggcaacttat cccaaacaag atctggacta acatgttcaa tgtgggacaa gaacatggaa     1260

gacttacatc gtcatatctt ctgggaacca gatgcaagta agctgaatga gaattactgc     1320

cgaaatccag atgatgatgc tcatggaccc tggtgctaca cgggaaatcc actcattcct     1380

tgggattatt gccctatttc tcgttgtgaa ggtgatacca cacctacaat agtcaattta     1440

gaccatcccg taatatcttg tgccaaaacg aaacaattgc gagttgtaaa tgggattcca     1500

acacgaacaa acataggatg gatggttagt ttgagataca gaaataaaca tatctgcgga     1560

ggatcattga taaaggagag ttgggttctt actgcacgac agtgtttccc ttctcgagac     1620

ttgaaagatt atgaagcttg gcttggaatt catgatgtcc acggaagagg agatgagaaa     1680

tgcaaacagg ttctcaatgt ttcccagctg gtatatggcc ctgaaggatc agatctggtt     1740

ttaatgaagc ttgccaggcc tgctgtcctg gatgattttg ttagtacgat tgatttacct     1800

aattatggat gcacaattcc tgaaaagacc agttgcagtg tttatggctg gggctacact     1860

ggattgatca actatgatgg cctattacga gtggcacatc tctatataat gggaaatgag     1920

aaatgcagcc agcatcatcg agggaaggtg actctgaatg agtctgaaat atgtgctggg     1980

gctgaaaaga ttggatcagg accatgtgag ggggattatg gtggcccact tgtttgtgag     2040

caacataaaa tgagaatggt tcttggtgtc attgttcctg gtcgtggatg tgccattcca     2100

aatcgtcctg gtatttttgt ccgagtagca tattatgcaa aatggataca caaaattatt     2160

ttaacatata aggtaccaca gtcatag                                         2187


<210>  10
<211>  534
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(534)
<223>  ACCESSION   NM_000880 (Human IL-7 cDNA)

<400>  10
atgttccatg tttcttttag gtatatcttt ggacttcctc ccctgatcct tgttctgttg       60

ccagtagcat catctgattg tgatattgaa ggtaaagatg gcaaacaata tgagagtgtt      120

ctaatggtca gcatcgatca attattggac agcatgaaag aaattggtag caattgcctg      180

aataatgaat ttaacttttt taaaagacat atctgtgatg ctaataagga aggtatgttt      240

ttattccgtg ctgctcgcaa gttgaggcaa tttcttaaaa tgaatagcac tggtgatttt      300

gatctccact tattaaaagt ttcagaaggc acaacaatac tgttgaactg cactggccag      360

gttaaaggaa gaaaaccagc tgccctgggt gaagcccaac caacaaagag tttggaagaa      420

aataaatctt taaaggaaca gaaaaaactg aatgacttgt gtttcctaaa gagactatta      480

caagagataa aaacttgttg gaataaaatt ttgatgggca ctaaagaaca ctga            534


<210>  11
<211>  2190
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(2190)
<223>  ACCESSION   NM_010427 XM_131908 (Mouse HGF cDNA)

<400>  11
agcatgatgt gggggaccaa acttctgccg gtcctgttgc tgcagcatgt cctcctgcac       60

ctcctcctgc ttcatgtcgc catcccctat gcagaaggac agaagaaaag aagaaataca      120

cttcatgaat ttaaaaagtc agcaaaaact actcttacca aggaagaccc attactgaag      180

attaaaacca aaaaagtgaa ctctgcagat gagtgtgcca acaggtgtat caggaacagg      240

ggctttacgt tcacttgcaa ggccttcgtt tttgataagt caagaaaacg atgctactgg      300

tatcctttca atagtatgtc aagtggagtg aaaaaagggt ttggccatga atttgacctc      360

tatgaaaaca aagactatat tagaaactgc atcattggta aaggaggcag ctataaaggg      420

acggtatcca tcactaagag tggcatcaaa tgccagcctt ggaattccat gatcccccat      480

gaacacagct ttttgccttc gagctatcgc ggtaaagacc tacaggaaaa ctactgtcga      540

aatcctcgag gggaagaagg gggaccctgg tgtttcacaa gcaatccaga ggtacgctac      600

gaagtctgtg acattcctca gtgttcagaa gttgaatgca tgacctgcaa tggtgaaagc      660

tacagaggtc ccatggatca cacagaatca ggcaagactt gtcagcgctg ggaccagcag      720

acaccacacc ggcacaagtt cttgccagaa agatatcccg acaagggctt tgatgataat      780

tattgccgca atcctgatgg caagccgagg ccatggtgct acactcttga ccctgacacc      840

acttgggagt attgtgcaat taaaacgtgc gctcacagtg ctgtgaatga gactgatgtc      900

cctatggaaa caactgaatg cattcaaggc caaggagaag gttacagggg aaccagcaat      960

accatttgga atggaattcc ctgtcagcgt tgggattcgc agtaccctca caagcatgat     1020

atcactcccg agaacttcaa atgcaaggac cttagagaaa attattgccg caatccagat     1080

ggggctgaat caccatggtg ttttaccact gacccaaaca tccgagttgg ctactgctct     1140

cagattccca agtgtgacgt gtcaagtgga caagattgtt atcgtggcaa tgggaaaaat     1200

tacatgggca acttatccaa aacaaggtct ggacttacat gttccatgtg ggacaagaat     1260

atggaggatt tacaccgtca tatcttctgg gagccagatg ctagcaaatt gaataagaat     1320

tactgccgga atcctgatga tgatgcccat ggaccttggt gctacacggg gaatcctctt     1380

attccttggg attattgccc tatttcccgt tgtgaaggag atactacacc tacaattgtc     1440

aatttggacc atcctgtaat atcctgtgcc aaaacaaaac aactgcgggt tgtaaatggc     1500

attccaacac aaacaacagt agggtggatg gttagtttga aatacagaaa taaacatatc     1560

tgtggaggat cattgataaa ggaaagttgg gttattactg caagacaatg ttttccagcc     1620

agaaacaaag acttgaaaga ctatgaagct tggcttggca tccacgatgt tcatgagaga     1680

ggcgaggaga agcgcaagca gatcttaaac atttcccagc tggtctatgg tcctgaaggc     1740

tcagacttgg ttttactgaa gcttgctcga cctgcaatcc tggataactt tgtcagtaca     1800

attgatttac ctagttatgg ttgtacaatc cctgaaaaga ccacttgcag tatttacggc     1860

tggggctaca ctggattgat caacgcggat ggtttattac gagtagctca tctgtatatt     1920

atggggaatg agaaatgcag tcagcaccat caaggcaagg tgactttgaa tgagtctgag     1980

ttatgtgctg gggctgaaaa gattggatca ggaccatgtg agggagatta tggtggccca     2040

ctcatttgtg aacaacacaa aatgagaatg gttcttggtg tcattgttcc tggtcgtgga     2100

tgtgccatcc caaatcgtcc tgttattttt gttcgagtag catattatgc aaaatggata     2160

cacaaagtaa ttttgacata caagttgtaa                                      2190


<210>  12
<211>  465
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(465)
<223>  ACCESSION   NM_008371 (Mouse IL-7 cDNA)

<400>  12
atgttccatg tttcttttag atatatcttt ggaattcctc cactgatcct tgttctgctg       60

cctgtcacat catctgagtg ccacattaaa gacaaagaag gtaaagcata tgagagtgta      120

ctgatgatca gcatcgatga attggacaaa atgacaggaa ctgatagtaa ttgcccgaat      180

aatgaaccaa acttttttag aaaacatgta tgtgatgata caaaggaagc tgcttttcta      240

aatcgtgctg ctcgcaagtt gaagcaattt cttaaaatga atatcagtga agaattcaat      300

gtccacttac taacagtatc acaaggcaca caaacactgg tgaactgcac aagtaaggaa      360

gaaaaaaacg taaaggaaca gaaaaagaat gatgcatgtt tcctaaagag actactgaga      420

gaaataaaaa cttgttggaa taaaattttg aagggcagta tataa                      465


<210>  13
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Human HGF beta-chain peptide

<400>  13

Val Val Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser 
1               5                   10                  15      


Leu 
    


<210>  14
<211>  234
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(234)
<223>  Human HGF-beta chain entire sequence (aa 495 to 728 of HGF)

<400>  14

Val Val Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser 
1               5                   10                  15      


Leu Arg Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu 
            20                  25                  30          


Ser Trp Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys 
        35                  40                  45              


Asp Tyr Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp 
    50                  55                  60                  


Glu Lys Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro 
65                  70                  75                  80  


Glu Gly Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu 
                85                  90                  95      


Asp Asp Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile 
            100                 105                 110         


Pro Glu Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu 
        115                 120                 125             


Ile Asn Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly 
    130                 135                 140                 


Asn Glu Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu 
145                 150                 155                 160 


Ser Glu Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu 
                165                 170                 175     


Gly Asp Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met 
            180                 185                 190         


Val Leu Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg 
        195                 200                 205             


Pro Gly Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys 
    210                 215                 220                 


Ile Ile Leu Thr Tyr Lys Val Pro Gln Ser 
225                 230                 


