                         SEQUENCE LISTING

<110>  KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
       Fleming, Sherry
       Tomich, John M.
 
<120>  B2-GLYCOPROTEIN I PEPTIDE INHIBITORS

<130>  Dkt. No. 42220-PCT

<150>  US 61/379,257
<151>  2010-09-01

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of human B2-glycoprotein I


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Cys or Ser

<400>  1

Ile His Phe Tyr Xaa Lys Asn Lys Glu Lys Lys Xaa Ser Tyr Thr Val 
1               5                   10                  15      


Glu Asp Ala Gln Xaa Arg Asp Gly Thr Ile 
            20                  25      


<210>  2
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of human B2-glycoprotein I


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Pro or Gly

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Cys or Ser

<400>  2

Lys Lys Xaa Ser Tyr Thr Val Glu Asp Ala Gln Xaa Arg Asp Gly Thr 
1               5                   10                  15      


Ile Glu Xaa Xaa Xaa Xaa Phe Lys Glu His Ser 
            20                  25          


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of human B2-glycoprotein I

<400>  3

Lys Lys Ser Ser Tyr Thr Val Glu Asp Ala Gln Ser 
1               5                   10          


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of human B2-glycloprotein I


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  D-amino acids

<400>  4

Ser Gln Ala Asp Glu Val Thr Tyr Ser Ser 
1               5                   10  


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of human B2-glycoprotein I


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Cys or Ser

<400>  5

Thr Glu Asp Ala Gln Xaa Ile Asp Gly Thr Ile Glu Val 
1               5                   10              


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of human B2-glycoprotein I


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Pro or Gly

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Cys or Ser

<400>  6

Xaa Ile Asp Gly Thr Ile Glu Val Xaa Lys Xaa 
1               5                   10      


<210>  7
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of human B2-glycoprotein I


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Cys or Ser

<400>  7

Lys Lys Xaa Ser Tyr Thr Glu Asp Ala Gln Xaa Ile Asp Gly Thr Ile 
1               5                   10                  15      


Glu Val Pro Lys Xaa Phe Lys Glu His Ser 
            20                  25      


<210>  8
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of human B2-glycoprotein I


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Cys or Ser

<400>  8

Val Ser Phe Phe Xaa Lys Asn Lys Glu Lys Lys Xaa Ser Tyr Thr Glu 
1               5                   10                  15      


Asp Ala Gln Xaa Ile Asp Gly Thr Ile 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of mouse B2-glycoprotein I


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Cys or Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Cys or Ser

<400>  9

Ile His Phe Tyr Xaa Lys Asn Lys Glu Lys Lys Xaa Ser Tyr Thr Val 
1               5                   10                  15      


Glu Ala His Xaa Arg Asp Gly Thr Ile 
            20                  25  


<210>  10
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of mouse B2-glycoprotein I

<400>  10

Lys Lys Cys Ser Tyr Thr Val Glu Ala His Cys Arg Asp Gly Thr Ile 
1               5                   10                  15      


Glu Ile Pro Ser Cys Phe Lys Glu His Ser 
            20                  25      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of mouse B2-glycoprotein I

<400>  11

Ser Lys Asn Lys Glu Lys Lys 
1               5           


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of mouse B2-glycoprotein I

<400>  12

Lys Lys Ser Ser Tyr Thr Val Glu Ala His Ser 
1               5                   10      


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of mouse B2-glycoprotein I


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  D-amino acids

<400>  13

Ser His Ala Glu Val Thr Tyr Ser Ser 
1               5                   


<210>  14
<211>  345
<212>  PRT
<213>  Murine

<400>  14

Met Val Ser Pro Val Leu Ala Leu Phe Ser Ala Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala Gly Arg Ile Cys Pro Lys Pro Asp Asp Leu Pro Phe Ala 
            20                  25                  30          


Thr Val Val Pro Leu Lys Thr Ser Tyr Asp Pro Gly Glu Gln Ile Val 
        35                  40                  45              


Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Arg Phe 
    50                  55                  60                  


Thr Cys Pro Leu Thr Gly Met Trp Pro Ile Asn Thr Leu Arg Cys Val 
65                  70                  75                  80  


Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ile Val Arg 
                85                  90                  95      


Tyr Thr Ser Phe Glu Tyr Pro Lys Asn Ile Ser Phe Ala Cys Asn Pro 
            100                 105                 110         


Gly Phe Phe Leu Asn Gly Thr Ser Ser Ser Lys Cys Thr Glu Glu Gly 
        115                 120                 125             


Lys Trp Ser Pro Asp Ile Pro Ala Cys Ala Arg Ile Thr Cys Pro Pro 
    130                 135                 140                 


Pro Pro Val Pro Lys Phe Ala Leu Leu Lys Asp Tyr Arg Pro Ser Ala 
145                 150                 155                 160 


Gly Asn Asn Ser Leu Tyr Gln Asp Thr Val Val Phe Lys Cys Leu Pro 
                165                 170                 175     


His Phe Ala Met Ile Gly Asn Asp Thr Val Met Cys Thr Glu Gln Gly 
            180                 185                 190         


Asn Trp Thr Arg Leu Pro Glu Cys Leu Glu Val Lys Cys Pro Phe Pro 
        195                 200                 205             


Pro Arg Pro Glu Asn Gly Tyr Val Asn Tyr Pro Ala Lys Pro Val Leu 
    210                 215                 220                 


Leu Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Glu Thr Tyr Lys Leu 
225                 230                 235                 240 


Asp Gly Pro Glu Glu Ala Glu Cys Thr Lys Thr Gly Thr Trp Ser Phe 
                245                 250                 255     


Leu Pro Thr Cys Arg Glu Ser Cys Lys Leu Pro Val Lys Lys Ala Thr 
            260                 265                 270         


Val Leu Tyr Gln Gly Met Arg Val Lys Ile Gln Glu Gln Phe Lys Asn 
        275                 280                 285             


Gly Met Met His Gly Asp Lys Ile His Phe Tyr Cys Lys Asn Lys Glu 
    290                 295                 300                 


Lys Lys Cys Ser Tyr Thr Val Glu Ala His Cys Arg Asp Gly Thr Ile 
305                 310                 315                 320 


Glu Ile Pro Ser Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys 
                325                 330                 335     


Thr Asp Ala Ser Glu Leu Thr Pro Cys 
            340                 345 


<210>  15
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser 
            20                  25                  30          


Thr Val Val Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr 
        35                  40                  45              


Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe 
    50                  55                  60                  


Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr 
65                  70                  75                  80  


Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg 
                85                  90                  95      


Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr 
            100                 105                 110         


Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly 
        115                 120                 125             


Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro 
    130                 135                 140                 


Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala 
145                 150                 155                 160 


Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro 
                165                 170                 175     


Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly 
            180                 185                 190         


Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro 
        195                 200                 205             


Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu 
    210                 215                 220                 


Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser Leu 
225                 230                 235                 240 


Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser Ala 
                245                 250                 255     


Met Pro Ser Cys Lys Ala Ser Cys Lys Val Pro Val Lys Lys Ala Thr 
            260                 265                 270         


Val Val Tyr Gln Gly Glu Arg Val Lys Ile Gln Glu Lys Phe Lys Asn 
        275                 280                 285             


Gly Met Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu 
    290                 295                 300                 


Lys Lys Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile 
305                 310                 315                 320 


Glu Val Pro Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys 
                325                 330                 335     


Thr Asp Ala Ser Asp Val Lys Pro Cys 
            340                 345 


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of mouse B2-glycoprotein I

<400>  16

Lys Asn Ile Ser Phe Ala Cys Asn Pro Gly Phe Phe Leu Asn Gly 
1               5                   10                  15  


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of mouse B2-glycoprotein I

<400>  17

Gly Asn Asp Thr Val Met Cys Thr Glu Gln Gln Asn 
1               5                   10          


<210>  18
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of mouse B2-glycoprotein I

<400>  18

Ile Pro Ser Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys Thr 
1               5                   10                  15      


Asp Ala Ser Glu Leu Thr Pro Cys 
            20                  


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of mouse B2-glycoprotein I

<400>  19

Lys Lys Ser Ser Tyr Thr Val Glu Ala His Ser Arg Asp Gly Thr Ile 
1               5                   10                  15      


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derivative of mouse B2-glycoprotein I

<400>  20

Asp Glu Val His Tyr Thr Thr Ser Ser Ser Lys Lys Ala Arg Gly Ile 
1               5                   10                  15      


Ile 
    


