                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Tetranectin-apolipoprotein A-I, lipid particles containing it and
        its use

<130>  26624

<150>  EP10008993.7
<151>  2010-08-30

<150>  EP10188392.4
<151>  2010-10-21

<160>  105   

<170>  PatentIn version 3.5

<210>  1
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tetranectin-apolipoprotein A-I (1)

<400>  1

Ala Pro Ile Val Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe 
1               5                   10                  15      


Glu Glu Leu Lys Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu 
            20                  25                  30          


Leu Lys Glu Gln Gln Ala Leu Gln Thr Val Asp Glu Pro Pro Gln Ser 
        35                  40                  45              


Pro Trp Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu 
    50                  55                  60                  


Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu 
65                  70                  75                  80  


Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr 
                85                  90                  95      


Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu 
            100                 105                 110         


Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met 
        115                 120                 125             


Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp 
    130                 135                 140                 


Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys 
145                 150                 155                 160 


Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu 
                165                 170                 175     


His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp 
            180                 185                 190         


Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr 
        195                 200                 205             


Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys 
    210                 215                 220                 


Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu 
225                 230                 235                 240 


His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu 
                245                 250                 255     


Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu 
            260                 265                 270         


Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
        275                 280                 285 


<210>  2
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tetranectin-apolipoprotein A-I (2)

<400>  2

Ile Val Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe Glu Glu 
1               5                   10                  15      


Leu Lys Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu Leu Lys 
            20                  25                  30          


Glu Gln Gln Ala Leu Gln Thr Val Asp Glu Pro Pro Gln Ser Pro Trp 
        35                  40                  45              


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
    50                  55                  60                  


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
65                  70                  75                  80  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
                85                  90                  95      


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
            100                 105                 110         


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
        115                 120                 125             


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
    130                 135                 140                 


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
145                 150                 155                 160 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
                165                 170                 175     


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
            180                 185                 190         


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
        195                 200                 205             


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
    210                 215                 220                 


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
225                 230                 235                 240 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
                245                 250                 255     


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
            260                 265                 270         


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
        275                 280             


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Leu Lys Gly Ser 
1               5   


<210>  4
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Apolipoprotein A-I mimetic (1)

<400>  4

Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Glu Leu Glu Ala 
1               5                   10                  15      


Leu Lys Gln Lys Leu Lys 
            20          


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Apolipoprotein A-I mimetic (2)

<400>  5

Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 
1               5                   10                  15      


Leu Lys Gln Lys Leu Lys 
            20          


<210>  6
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  7
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly Ala Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu Ser 
            20                  25                  30          


Leu Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu 
        35                  40                  45              


Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 
    50                  55                  60                  


Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly 
65                  70                  75                  80  


Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr Gln 
                85                  90                  95      


Pro Ala Thr Gln 
            100 


<210>  8
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Phe Leu Lys Ala Val Val Leu Thr Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Gly Ala Arg Ala Glu Val Ser Ala Asp Gln Val Ala Thr Val Met Trp 
            20                  25                  30          


Asp Tyr Phe Ser Gln Leu Ser Asn Asn Ala Lys Glu Ala Val Glu His 
        35                  40                  45              


Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu Asn Ala Leu Phe Gln Asp 
    50                  55                  60                  


Lys Leu Gly Glu Val Asn Thr Tyr Ala Gly Asp Leu Gln Lys Lys Leu 
65                  70                  75                  80  


Val Pro Phe Ala Thr Glu Leu His Glu Arg Leu Ala Lys Asp Ser Glu 
                85                  90                  95      


Lys Leu Lys Glu Glu Ile Gly Lys Glu Leu Glu Glu Leu Arg Ala Arg 
            100                 105                 110         


Leu Leu Pro His Ala Asn Glu Val Ser Gln Lys Ile Gly Asp Asn Leu 
        115                 120                 125             


Arg Glu Leu Gln Gln Arg Leu Glu Pro Tyr Ala Asp Gln Leu Arg Thr 
    130                 135                 140                 


Gln Val Asn Thr Gln Ala Glu Gln Leu Arg Arg Gln Leu Thr Pro Tyr 
145                 150                 155                 160 


Ala Gln Arg Met Glu Arg Val Leu Arg Glu Asn Ala Asp Ser Leu Gln 
                165                 170                 175     


Ala Ser Leu Arg Pro His Ala Asp Glu Leu Lys Ala Lys Ile Asp Gln 
            180                 185                 190         


Asn Val Glu Glu Leu Lys Gly Arg Leu Thr Pro Tyr Ala Asp Glu Phe 
        195                 200                 205             


Lys Val Lys Ile Asp Gln Thr Val Glu Glu Leu Arg Arg Ser Leu Ala 
    210                 215                 220                 


Pro Tyr Ala Gln Asp Thr Gln Glu Lys Leu Asn His Gln Leu Glu Gly 
225                 230                 235                 240 


Leu Thr Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys Ala Arg Ile 
                245                 250                 255     


Ser Ala Ser Ala Glu Glu Leu Arg Gln Arg Leu Ala Pro Leu Ala Glu 
            260                 265                 270         


Asp Val Arg Gly Asn Leu Arg Gly Asn Thr Glu Gly Leu Gln Lys Ser 
        275                 280                 285             


Leu Ala Glu Leu Gly Gly His Leu Asp Gln Gln Val Glu Glu Phe Arg 
    290                 295                 300                 


Arg Arg Val Glu Pro Tyr Gly Glu Asn Phe Asn Lys Ala Leu Val Gln 
305                 310                 315                 320 


Gln Met Glu Gln Leu Arg Gln Lys Leu Gly Pro His Ala Gly Asp Val 
                325                 330                 335     


Glu Gly His Leu Ser Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 
            340                 345                 350         


Ser Phe Phe Ser Thr Phe Lys Glu Lys Glu Ser Gln Asp Lys Thr Leu 
        355                 360                 365             


Ser Leu Pro Glu Leu Glu Gln Gln Gln Glu Gln Gln Gln Glu Gln Gln 
    370                 375                 380                 


Gln Glu Gln Val Gln Met Leu Ala Pro Leu Glu Ser 
385                 390                 395     


<210>  9
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser 
1               5                   10                  15      


Ala Phe Ser Ala Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser 
            20                  25                  30          


Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln Ile His Gln Gln Lys 
        35                  40                  45              


Met Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu 
    50                  55                  60                  


Asn Asn Met Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser Gly Ser 
65                  70                  75                  80  


Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln Leu 
                85                  90                  95      


Gln Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala 
            100                 105                 110         


Glu Ala His Glu Leu Val Gly Trp Asn Leu Glu Gly Leu Arg Gln Gln 
        115                 120                 125             


Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val 
    130                 135                 140                 


Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr Lys Ala 
145                 150                 155                 160 


Gln Leu Leu Gly Gly Val Asp Glu Ala Trp Ala Leu Leu Gln Gly Leu 
                165                 170                 175     


Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys Glu Leu Phe His 
            180                 185                 190         


Pro Tyr Ala Glu Ser Leu Val Ser Gly Ile Gly Arg His Val Gln Glu 
        195                 200                 205             


Leu His Arg Ser Val Ala Pro His Ala Pro Ala Ser Pro Ala Arg Leu 
    210                 215                 220                 


Ser Arg Cys Val Gln Val Leu Ser Arg Lys Leu Thr Leu Lys Ala Lys 
225                 230                 235                 240 


Ala Leu His Ala Arg Ile Gln Gln Asn Leu Asp Gln Leu Arg Glu Glu 
                245                 250                 255     


Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala Gly Pro 
            260                 265                 270         


Asp Pro Gln Met Leu Ser Glu Glu Val Arg Gln Arg Leu Gln Ala Phe 
        275                 280                 285             


Arg Gln Asp Thr Tyr Leu Gln Ile Ala Ala Phe Thr Arg Ala Ile Asp 
    290                 295                 300                 


Gln Glu Thr Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro Pro Gly 
305                 310                 315                 320 


His Ser Ala Phe Ala Pro Glu Phe Gln Gln Thr Asp Ser Gly Lys Val 
                325                 330                 335     


Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp Glu Asp Ile Thr 
            340                 345                 350         


His Ser Leu His Asp Gln Gly His Ser His Leu Gly Asp Pro 
        355                 360                 365     


<210>  10
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 
65                  70                  75                  80  


Ile Asp Ser 
            


<210>  11
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Thr Arg Leu Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu 
1               5                   10                  15      


Gly Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro 
            20                  25                  30          


Ser Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp 
        35                  40                  45              


Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu 
    50                  55                  60                  


Pro Ala Val Asp Glu Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala 
65                  70                  75                  80  


Ala Met Ser Thr Tyr Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val 
                85                  90                  95      


Leu Lys Gly Glu Glu 
            100     


<210>  12
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 
            20                  25                  30          


Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser 
        35                  40                  45              


Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr 
    50                  55                  60                  


Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys 
65                  70                  75                  80  


Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr Ser Ala 
                85                  90                  95      


Val Ala Ala 
            


<210>  13
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Leu Leu Arg Asn Arg Leu Gln Ala Leu Pro Ala Leu Cys Leu 
1               5                   10                  15      


Cys Val Leu Val Leu Ala Cys Ile Gly Ala Cys Gln Pro Glu Ala Gln 
            20                  25                  30          


Glu Gly Thr Leu Ser Pro Pro Pro Lys Leu Lys Met Ser Arg Trp Ser 
        35                  40                  45              


Leu Val Arg Gly Arg Met Lys Glu Leu Leu Glu Thr Val Val Asn Arg 
    50                  55                  60                  


Thr Arg Asp Gly Trp Gln Trp Phe Trp Ser Pro Ser Thr Phe Arg Gly 
65                  70                  75                  80  


Phe Met Gln Thr Tyr Tyr Asp Asp His Leu Arg Asp Leu Gly Pro Leu 
                85                  90                  95      


Thr Lys Ala Trp Phe Leu Glu Ser Lys Asp Ser Leu Leu Lys Lys Thr 
            100                 105                 110         


His Ser Leu Cys Pro Arg Leu Val Cys Gly Asp Lys Asp Gln Gly 
        115                 120                 125         


<210>  14
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 
1               5                   10                  15      


Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 
            20                  25                  30          


Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu 
        35                  40                  45              


Ile Glu Lys Ile Pro Thr Thr Phe Glu Asn Gly Arg Cys Ile Gln Ala 
    50                  55                  60                  


Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu 
65                  70                  75                  80  


Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro 
                85                  90                  95      


Val Asn Leu Thr Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe 
            100                 105                 110         


Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Thr Asp Tyr Glu Asn Tyr 
        115                 120                 125             


Ala Leu Val Tyr Ser Cys Thr Cys Ile Ile Gln Leu Phe His Val Asp 
    130                 135                 140                 


Phe Ala Trp Ile Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Thr Val 
145                 150                 155                 160 


Asp Ser Leu Lys Asn Ile Leu Thr Ser Asn Asn Ile Asp Val Lys Lys 
                165                 170                 175     


Met Thr Val Thr Asp Gln Val Asn Cys Pro Lys Leu Ser 
            180                 185                 


<210>  15
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210>  16
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ile Pro Val Glu Leu Leu Leu Cys Tyr Leu Leu Leu His Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Tyr Gly Lys Gln Thr Asn Val Leu Met His Phe Pro 
            20                  25                  30          


Leu Ser Leu Glu Ser Gln Thr Pro Ser Ser Asp Pro Leu Ser Cys Gln 
        35                  40                  45              


Phe Leu His Pro Lys Ser Leu Pro Gly Phe Ser His Met Ala Pro Leu 
    50                  55                  60                  


Pro Lys Phe Leu Val Ser Leu Ala Leu Arg Asn Ala Leu Glu Glu Ala 
65                  70                  75                  80  


Gly Cys Gln Ala Asp Val Trp Ala Leu Gln Leu Gln Leu Tyr Arg Gln 
                85                  90                  95      


Gly Gly Val Asn Ala Thr Gln Val Leu Ile Gln His Leu Arg Gly Leu 
            100                 105                 110         


Gln Lys Gly Arg Ser Thr Glu Arg Asn Val Ser Val Glu Ala Leu Ala 
        115                 120                 125             


Ser Ala Leu Gln Leu Leu Ala Arg Glu Gln Gln Ser Thr Gly Arg Val 
    130                 135                 140                 


Gly Arg Ser Leu Pro Thr Glu Asp Cys Glu Asn Glu Lys Glu Gln Ala 
145                 150                 155                 160 


Val His Asn Val Val Gln Leu Leu Pro Gly Val Gly Thr Phe Tyr Asn 
                165                 170                 175     


Leu Gly Thr Ala Leu Tyr Tyr Ala Thr Gln Asn Cys Leu Gly Lys Ala 
            180                 185                 190         


Arg Glu Arg Gly Arg Asp Gly Ala Ile Asp Leu Gly Tyr Asp Leu Leu 
        195                 200                 205             


Met Thr Met Ala Gly Met Ser Gly Gly Pro Met Gly Leu Ala Ile Ser 
    210                 215                 220                 


Ala Ala Leu Lys Pro Ala Leu Arg Ser Gly Val Gln Gln Leu Ile Gln 
225                 230                 235                 240 


Tyr Tyr Gln Asp Gln Lys Asp Ala Asn Ile Ser Gln Pro Glu Thr Thr 
                245                 250                 255     


Lys Glu Gly Leu Arg Ala Ile Ser Asp Val Ser Asp Leu Glu Glu Thr 
            260                 265                 270         


Thr Thr Leu Ala Ser Phe Ile Ser Glu Val Val Ser Ser Ala Pro Tyr 
        275                 280                 285             


Trp Gly Trp Ala Ile Ile Lys Ser Tyr Asp Leu Asp Pro Gly Ala Gly 
    290                 295                 300                 


Ser Leu Glu Ile 
305             


<210>  17
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser 
            20                  25                  30          


Thr Val Val Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr 
        35                  40                  45              


Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe 
    50                  55                  60                  


Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr 
65                  70                  75                  80  


Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg 
                85                  90                  95      


Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr 
            100                 105                 110         


Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly 
        115                 120                 125             


Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro 
    130                 135                 140                 


Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala 
145                 150                 155                 160 


Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro 
                165                 170                 175     


Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly 
            180                 185                 190         


Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro 
        195                 200                 205             


Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu 
    210                 215                 220                 


Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser Leu 
225                 230                 235                 240 


Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser Ala 
                245                 250                 255     


Met Pro Ser Cys Lys Ala Ser Cys Lys Val Pro Val Lys Lys Ala Thr 
            260                 265                 270         


Val Val Tyr Gln Gly Glu Arg Val Lys Ile Gln Glu Lys Phe Lys Asn 
        275                 280                 285             


Gly Met Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu 
    290                 295                 300                 


Lys Lys Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile 
305                 310                 315                 320 


Glu Val Pro Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys 
                325                 330                 335     


Thr Asp Ala Ser Asp Val Lys Pro Cys 
            340                 345 


<210>  18
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 
    50                  55                  60                  


Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser 
65                  70                  75                  80  


Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 
                85                  90                  95      


Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 
            100                 105                 110         


Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 
        115                 120                 125             


Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 
    130                 135                 140                 


Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala 
145                 150                 155                 160 


Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn 
                165                 170                 175     


Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val 
            180                 185                 190         


Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu 
        195                 200                 205             


Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr 
    210                 215                 220                 


Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala 
225                 230                 235                 240 


His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu 
                245                 250                 255     


Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr 
            260                 265                 270         


Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg 
        275                 280                 285             


Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro 
    290                 295                 300                 


Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg 
305                 310                 315                 320 


Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr 
                325                 330                 335     


Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu 
            340                 345                 350         


Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala 
        355                 360                 365             


Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile 
    370                 375                 380                 


Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
385                 390                 395             


<210>  19
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu Lys Tyr Phe 
1               5                   10                  15      


Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu Thr Asp Asp 
            20                  25                  30          


Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45              


Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser His Met Val 
    50                  55                  60                  


Met Lys Asp Lys Asn Arg His Asp Lys Asp Gln Gln His Arg Gln Trp 
65                  70                  75                  80  


Phe Leu Lys Glu Phe Pro Arg Leu Lys Arg Glu Leu Glu Asp His Ile 
                85                  90                  95      


Arg Lys Leu Arg Ala Leu Ala Glu Glu Val Glu Gln Val His Arg Gly 
            100                 105                 110         


Thr Thr Ile Ala Asn Val Val Ser Asn Ser Val Gly Thr Thr Ser Gly 
        115                 120                 125             


Ile Leu Thr Leu Leu Gly Leu Gly Leu Ala Pro Phe Thr Glu Gly Ile 
    130                 135                 140                 


Ser Phe Val Leu Leu Asp Thr Gly Met Gly Leu Gly Ala Ala Ala Ala 
145                 150                 155                 160 


Val Ala Gly Ile Thr Cys Ser Val Val Glu Leu Val Asn Lys Leu Arg 
                165                 170                 175     


Ala Arg Ala Gln Ala Arg Asn Leu Asp Gln Ser Gly Thr Asn Val Ala 
            180                 185                 190         


Lys Val Met Lys Glu Phe Val Gly Gly Asn Thr Pro Asn Val Leu Thr 
        195                 200                 205             


Leu Val Asp Asn Trp Tyr Gln Val Thr Gln Gly Ile Gly Arg Asn Ile 
    210                 215                 220                 


Arg Ala Ile Arg Arg Ala Arg Ala Asn Pro Gln Leu Gly Ala Tyr Ala 
225                 230                 235                 240 


Pro Pro Pro His Ile Ile Gly Arg Ile Ser Ala Glu Gly Gly Glu Gln 
                245                 250                 255     


Val Glu Arg Val Val Glu Gly Pro Ala Gln Ala Met Ser Arg Gly Thr 
            260                 265                 270         


Met Ile Val Gly Ala Ala Thr Gly Gly Ile Leu Leu Leu Leu Asp Val 
        275                 280                 285             


Val Ser Leu Ala Tyr Glu Ser Lys His Leu Leu Glu Gly Ala Lys Ser 
    290                 295                 300                 


Glu Ser Ala Glu Glu Leu Lys Lys Arg Ala Gln Glu Leu Glu Gly Lys 
305                 310                 315                 320 


Leu Asn Phe Leu Thr Lys Ile His Glu Met Leu Gln Pro Gly Gln Asp 
                325                 330                 335     


Gln 
    


<210>  20
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys 
1               5                   10                  15      


Leu Ile Arg Ser Cys Cys Gln Val Val Thr Phe Thr Phe Pro Phe Gly 
            20                  25                  30          


Phe Gln Gly Ile Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala 
        35                  40                  45              


Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser 
    50                  55                  60                  


Cys Ser His Ser Phe Lys Arg Ser Phe Leu Glu Lys Lys Arg Phe Thr 
65                  70                  75                  80  


Glu Glu Ala Thr Lys Tyr Phe Arg Glu Arg Val Ser Pro Val His Leu 
                85                  90                  95      


Gln Ile Leu Leu Thr Asn Asn Glu Ala Trp Lys Arg Phe Val Thr Ala 
            100                 105                 110         


Ala Glu Leu Pro Arg Asp Glu Ala Asp Ala Leu Tyr Glu Ala Leu Lys 
        115                 120                 125             


Lys Leu Arg Thr Tyr Ala Ala Ile Glu Asp Glu Tyr Val Gln Gln Lys 
    130                 135                 140                 


Asp Glu Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Val Lys 
145                 150                 155                 160 


Arg Lys Ile Gln Glu Ser Ile Glu Lys Leu Arg Ala Leu Ala Asn Gly 
                165                 170                 175     


Ile Glu Glu Val His Arg Gly Cys Thr Ile Ser Asn Val Val Ser Ser 
            180                 185                 190         


Ser Thr Gly Ala Ala Ser Gly Ile Met Ser Leu Ala Gly Leu Val Leu 
        195                 200                 205             


Ala Pro Phe Thr Ala Gly Thr Ser Leu Ala Leu Thr Ala Ala Gly Val 
    210                 215                 220                 


Gly Leu Gly Ala Ala Ser Ala Val Thr Gly Ile Thr Thr Ser Ile Val 
225                 230                 235                 240 


Glu His Ser Tyr Thr Ser Ser Ala Glu Ala Glu Ala Ser Arg Leu Thr 
                245                 250                 255     


Ala Thr Ser Ile Asp Arg Leu Lys Val Phe Lys Glu Val Met Arg Asp 
            260                 265                 270         


Ile Thr Pro Asn Leu Leu Ser Leu Leu Asn Asn Tyr Tyr Glu Ala Thr 
        275                 280                 285             


Gln Thr Ile Gly Ser Glu Ile Arg Ala Ile Arg Gln Ala Arg Ala Arg 
    290                 295                 300                 


Ala Arg Leu Pro Val Thr Thr Trp Arg Ile Ser Ala Gly Ser Gly Gly 
305                 310                 315                 320 


Gln Ala Glu Arg Thr Ile Ala Gly Thr Thr Arg Ala Val Ser Arg Gly 
                325                 330                 335     


Ala Arg Ile Leu Ser Ala Thr Thr Ser Gly Ile Phe Leu Ala Leu Asp 
            340                 345                 350         


Val Val Asn Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
        355                 360                 365             


Ser Ala Ser Ala Glu Glu Leu Arg Arg Gln Ala Gln Glu Leu Glu Glu 
    370                 375                 380                 


Asn Leu Met Glu Leu Thr Gln Ile Tyr Gln Arg Leu Asn Pro Cys His 
385                 390                 395                 400 


Thr His 
        


<210>  21
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu Gly Ala Ala Leu Leu Lys Ile Phe Val Val Cys Ile Trp Val 
1               5                   10                  15      


Gln Gln Asn His Pro Gly Trp Thr Val Ala Gly Gln Phe Gln Glu Lys 
            20                  25                  30          


Lys Arg Phe Thr Glu Glu Val Ile Glu Tyr Phe Gln Lys Lys Val Ser 
        35                  40                  45              


Pro Val His Leu Lys Ile Leu Leu Thr Ser Asp Glu Ala Trp Lys Arg 
    50                  55                  60                  


Phe Val Arg Val Ala Glu Leu Pro Arg Glu Glu Ala Asp Ala Leu Tyr 
65                  70                  75                  80  


Glu Ala Leu Lys Asn Leu Thr Pro Tyr Val Ala Ile Glu Asp Lys Asp 
                85                  90                  95      


Met Gln Gln Lys Glu Gln Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe 
            100                 105                 110         


Pro Gln Ile Arg Trp Lys Ile Gln Glu Ser Ile Glu Arg Leu Arg Val 
        115                 120                 125             


Ile Ala Asn Glu Ile Glu Lys Val His Arg Gly Cys Val Ile Ala Asn 
    130                 135                 140                 


Val Val Ser Gly Ser Thr Gly Ile Leu Ser Val Ile Gly Val Met Leu 
145                 150                 155                 160 


Ala Pro Phe Thr Ala Gly Leu Ser Leu Ser Ile Thr Ala Ala Gly Val 
                165                 170                 175     


Gly Leu Gly Ile Ala Ser Ala Thr Ala Gly Ile Ala Ser Ser Ile Val 
            180                 185                 190         


Glu Asn Thr Tyr Thr Arg Ser Ala Glu Leu Thr Ala Ser Arg Leu Thr 
        195                 200                 205             


Ala Thr Ser Thr Asp Gln Leu Glu Ala Leu Arg Asp Ile Leu Arg Asp 
    210                 215                 220                 


Ile Thr Pro Asn Val Leu Ser Phe Ala Leu Asp Phe Asp Glu Ala Thr 
225                 230                 235                 240 


Lys Met Ile Ala Asn Asp Val His Thr Leu Arg Arg Ser Lys Ala Thr 
                245                 250                 255     


Val Gly Arg Pro Leu Ile Ala Trp Arg Tyr Val Pro Ile Asn Val Val 
            260                 265                 270         


Glu Thr Leu Arg Thr Arg Gly Ala Pro Thr Arg Ile Val Arg Lys Val 
        275                 280                 285             


Ala Arg Asn Leu Gly Lys Ala Thr Ser Gly Val Leu Val Val Leu Asp 
    290                 295                 300                 


Val Val Asn Leu Val Gln Asp Ser Leu Asp Leu His Lys Gly Ala Lys 
305                 310                 315                 320 


Ser Glu Ser Ala Glu Ser Leu Arg Gln Trp Ala Gln Glu Leu Glu Glu 
                325                 330                 335     


Asn Leu Asn Glu Leu Thr His Ile His Gln Ser Leu Lys Ala Gly 
            340                 345                 350     


<210>  22
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Cys Gly Lys Gln Gly Asn Leu Gln Val Pro Gly Ser Lys Val 
1               5                   10                  15      


Leu Pro Gly Leu Gly Glu Gly Cys Lys Glu Met Trp Leu Arg Lys Val 
            20                  25                  30          


Ile Tyr Gly Gly Glu Val Trp Gly Lys Ser Pro Glu Pro Glu Phe Pro 
        35                  40                  45              


Ser Leu Val Asn Leu Cys Gln Ser Trp Lys Ile Asn Asn Leu Met Ser 
    50                  55                  60                  


Thr Val His Ser Asp Glu Ala Gly Met Leu Ser Tyr Phe Leu Phe Glu 
65                  70                  75                  80  


Glu Leu Met Arg Cys Asp Lys Asp Ser Met Pro Asp Gly Asn Leu Ser 
                85                  90                  95      


Glu Glu Glu Lys Leu Phe Leu Ser Tyr Phe Pro Leu His Lys Phe Glu 
            100                 105                 110         


Leu Glu Gln Asn Ile Lys Glu Leu Asn Thr Leu Ala Asp Gln Val Asp 
        115                 120                 125             


Thr Thr His Glu Leu Leu Thr Lys Thr Ser Leu Val Ala Ser Ser Ser 
    130                 135                 140                 


Gly Ala Val Ser Gly Val Met Asn Ile Leu Gly Leu Ala Leu Ala Pro 
145                 150                 155                 160 


Val Thr Ala Gly Gly Ser Leu Met Leu Ser Ala Thr Gly Thr Gly Leu 
                165                 170                 175     


Gly Ala Ala Ala Ala Ile Thr Asn Ile Val Thr Asn Val Leu Glu Asn 
            180                 185                 190         


Arg Ser Asn Ser Ala Ala Arg Asp Lys Ala Ser Arg Leu Gly Pro Leu 
        195                 200                 205             


Thr Thr Ser His Glu Ala Phe Gly Gly Ile Asn Trp Ser Glu Ile Glu 
    210                 215                 220                 


Ala Ala Gly Phe Cys Val Asn Lys Cys Val Lys Ala Ile Gln Gly Ile 
225                 230                 235                 240 


Lys Asp Leu His Ala Tyr Gln Met Ala Lys Ser Asn Ser Gly Phe Met 
                245                 250                 255     


Ala Met Val Lys Asn Phe Val Ala Lys Arg His Ile Pro Phe Trp Thr 
            260                 265                 270         


Ala Arg Gly Val Gln Arg Ala Phe Glu Gly Thr Thr Leu Ala Met Thr 
        275                 280                 285             


Asn Gly Ala Trp Val Met Gly Ala Ala Gly Ala Gly Phe Leu Leu Met 
    290                 295                 300                 


Lys Asp Met Ser Ser Phe Leu Gln Ser Trp Lys His Leu Glu Asp Gly 
305                 310                 315                 320 


Ala Arg Thr Glu Thr Ala Glu Glu Leu Arg Ala Leu Ala Lys Lys Leu 
                325                 330                 335     


Glu Gln Glu Leu Asp Arg Leu Thr Gln His His Arg His Leu Pro Gln 
            340                 345                 350         


Lys Ala Ser Gln Thr Cys Ser Ser Ser Arg Gly Arg Ala Val Arg Gly 
        355                 360                 365             


Ser Arg Val Val Lys Pro Glu Gly Ser Arg Ser Pro Leu Pro Trp Pro 
    370                 375                 380                 


Val Val Glu His Gln Pro Arg Leu Gly Pro Gly Val Ala Leu Arg Thr 
385                 390                 395                 400 


Pro Lys Arg Thr Val Ser Ala Pro Arg Met Leu Gly His Gln Pro Ala 
                405                 410                 415     


Pro Pro Ala Pro Ala Arg Lys Gly Arg Gln Ala Pro Gly Arg His Arg 
            420                 425                 430         


Gln 
    


<210>  23
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asp Asn Gln Ala Glu Arg Glu Ser Glu Ala Gly Val Gly Leu Gln 
1               5                   10                  15      


Arg Asp Glu Asp Asp Ala Pro Leu Cys Glu Asp Val Glu Leu Gln Asp 
            20                  25                  30          


Gly Asp Leu Ser Pro Glu Glu Lys Ile Phe Leu Arg Glu Phe Pro Arg 
        35                  40                  45              


Leu Lys Glu Asp Leu Lys Gly Asn Ile Asp Lys Leu Arg Ala Leu Ala 
    50                  55                  60                  


Asp Asp Ile Asp Lys Thr His Lys Lys Phe Thr Lys Ala Asn Met Val 
65                  70                  75                  80  


Ala Thr Ser Thr Ala Val Ile Ser Gly Val Met Ser Leu Leu Gly Leu 
                85                  90                  95      


Ala Leu Ala Pro Ala Thr Gly Gly Gly Ser Leu Leu Leu Ser Thr Ala 
            100                 105                 110         


Gly Gln Gly Leu Ala Thr Ala Ala Gly Val Thr Ser Ile Val Ser Gly 
        115                 120                 125             


Thr Leu Glu Arg Ser Lys Asn Lys Glu Ala Gln Ala Arg Ala Glu Asp 
    130                 135                 140                 


Ile Leu Pro Thr Tyr Asp Gln Glu Asp Arg Glu Asp Glu Glu Glu Lys 
145                 150                 155                 160 


Ala Asp Tyr Val Thr Ala Ala Gly Lys Ile Ile Tyr Asn Leu Arg Asn 
                165                 170                 175     


Thr Leu Lys Tyr Ala Lys Lys Asn Val Arg Ala Phe Trp Lys Leu Arg 
            180                 185                 190         


Ala Asn Pro Arg Leu Ala Asn Ala Thr Lys Arg Leu Leu Thr Thr Gly 
        195                 200                 205             


Gln Val Ser Ser Arg Ser Arg Val Gln Val Gln Lys Ala Phe Ala Gly 
    210                 215                 220                 


Thr Thr Leu Ala Met Thr Lys Asn Ala Arg Val Leu Gly Gly Val Met 
225                 230                 235                 240 


Ser Ala Phe Ser Leu Gly Tyr Asp Leu Ala Thr Leu Ser Lys Glu Trp 
                245                 250                 255     


Lys His Leu Lys Glu Gly Ala Arg Thr Lys Phe Ala Glu Glu Leu Arg 
            260                 265                 270         


Ala Lys Ala Leu Glu Leu Glu Arg Lys Leu Thr Glu Leu Thr Gln Leu 
        275                 280                 285             


Tyr Lys Ser Leu Gln Gln Lys Val Arg Ser Arg Ala Arg Gly Val Gly 
    290                 295                 300                 


Lys Asp Leu Thr Gly Thr Cys Glu Thr Glu Ala Tyr Trp Lys Glu Leu 
305                 310                 315                 320 


Arg Glu His Val Trp Met Trp Leu Trp Leu Cys Val Cys Leu Cys Val 
                325                 330                 335     


Cys Val Tyr Val Gln Phe Thr 
            340             


<210>  24
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Phe His Gln Ile Trp Ala Ala Leu Leu Tyr Phe Tyr Gly Ile Ile 
1               5                   10                  15      


Leu Asn Ser Ile Tyr Gln Cys Pro Glu His Ser Gln Leu Thr Thr Leu 
            20                  25                  30          


Gly Val Asp Gly Lys Glu Phe Pro Glu Val His Leu Gly Gln Trp Tyr 
        35                  40                  45              


Phe Ile Ala Gly Ala Ala Pro Thr Lys Glu Glu Leu Ala Thr Phe Asp 
    50                  55                  60                  


Pro Val Asp Asn Ile Val Phe Asn Met Ala Ala Gly Ser Ala Pro Met 
65                  70                  75                  80  


Gln Leu His Leu Arg Ala Thr Ile Arg Met Lys Asp Gly Leu Cys Val 
                85                  90                  95      


Pro Arg Lys Trp Ile Tyr His Leu Thr Glu Gly Ser Thr Asp Leu Arg 
            100                 105                 110         


Thr Glu Gly Arg Pro Asp Met Lys Thr Glu Leu Phe Ser Ser Ser Cys 
        115                 120                 125             


Pro Gly Gly Ile Met Leu Asn Glu Thr Gly Gln Gly Tyr Gln Arg Phe 
    130                 135                 140                 


Leu Leu Tyr Asn Arg Ser Pro His Pro Pro Glu Lys Cys Val Glu Glu 
145                 150                 155                 160 


Phe Lys Ser Leu Thr Ser Cys Leu Asp Ser Lys Ala Phe Leu Leu Thr 
                165                 170                 175     


Pro Arg Asn Gln Glu Ala Cys Glu Leu Ser Asn Asn 
            180                 185             


<210>  25
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Phe Lys Val Ile Gln Arg Ser Val Gly Pro Ala Ser Leu Ser Leu 
1               5                   10                  15      


Leu Thr Phe Lys Val Tyr Ala Ala Pro Lys Lys Asp Ser Pro Pro Lys 
            20                  25                  30          


Asn Ser Val Lys Val Asp Glu Leu Ser Leu Tyr Ser Val Pro Glu Gly 
        35                  40                  45              


Gln Ser Lys Tyr Val Glu Glu Ala Arg Ser Gln Leu Glu Glu Ser Ile 
    50                  55                  60                  


Ser Gln Leu Arg His Tyr Cys Glu Pro Tyr Thr Thr Trp Cys Gln Glu 
65                  70                  75                  80  


Thr Tyr Ser Gln Thr Lys Pro Lys Met Gln Ser Leu Val Gln Trp Gly 
                85                  90                  95      


Leu Asp Ser Tyr Asp Tyr Leu Gln Asn Ala Pro Pro Gly Phe Phe Pro 
            100                 105                 110         


Arg Leu Gly Val Ile Gly Phe Ala Gly Leu Ile Gly Leu Leu Leu Ala 
        115                 120                 125             


Arg Gly Ser Lys Ile Lys Lys Leu Val Tyr Pro Pro Gly Phe Met Gly 
    130                 135                 140                 


Leu Ala Ala Ser Leu Tyr Tyr Pro Gln Gln Ala Ile Val Phe Ala Gln 
145                 150                 155                 160 


Val Ser Gly Glu Arg Leu Tyr Asp Trp Gly Leu Arg Gly Tyr Ile Val 
                165                 170                 175     


Ile Glu Asp Leu Trp Lys Glu Asn Phe Gln Lys Pro Gly Asn Val Lys 
            180                 185                 190         


Asn Ser Pro Gly Thr Lys 
        195             


<210>  26
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ala Ile Arg Met Gly Lys Leu Thr Thr Met Pro Ala Gly Leu 
1               5                   10                  15      


Ile Tyr Ala Ser Val Ser Val His Ala Ala Lys Gln Glu Glu Ser Lys 
            20                  25                  30          


Lys Gln Leu Val Lys Pro Glu Gln Leu Pro Ile Tyr Thr Ala Pro Pro 
        35                  40                  45              


Leu Gln Ser Lys Tyr Val Glu Glu Gln Pro Gly His Leu Gln Met Gly 
    50                  55                  60                  


Phe Ala Ser Ile Arg Thr Ala Thr Gly Cys Tyr Ile Gly Trp Cys Lys 
65                  70                  75                  80  


Gly Val Tyr Val Phe Val Lys Asn Gly Ile Met Asp Thr Val Gln Phe 
                85                  90                  95      


Gly Lys Asp Ala Tyr Val Tyr Leu Lys Asn Pro Pro Arg Asp Phe Leu 
            100                 105                 110         


Pro Lys Met Gly Val Ile Thr Val Ser Gly Leu Ala Gly Leu Val Ser 
        115                 120                 125             


Ala Arg Lys Gly Ser Lys Phe Lys Lys Ile Thr Tyr Pro Leu Gly Leu 
    130                 135                 140                 


Ala Thr Leu Gly Ala Thr Val Cys Tyr Pro Val Gln Ser Val Ile Ile 
145                 150                 155                 160 


Ala Lys Val Thr Ala Lys Lys Val Tyr Ala Thr Ser Gln Gln Ile Phe 
                165                 170                 175     


Gly Ala Val Lys Ser Leu Trp Thr Lys Ser Ser Lys Glu Glu Ser Leu 
            180                 185                 190         


Pro Lys Pro Lys Glu Lys Thr Lys Leu Gly Ser Ser Ser Glu Ile Glu 
        195                 200                 205             


Val Pro Ala Lys Thr Thr His Val Leu Lys His Ser Val Pro Leu Pro 
    210                 215                 220                 


Thr Glu Leu Ser Ser Glu Ala Lys Thr Lys Ser Glu Ser Thr Ser Gly 
225                 230                 235                 240 


Ala Thr Gln Phe Met Pro Asp Pro Lys Leu Met Asp His Gly Gln Ser 
                245                 250                 255     


His Pro Glu Asp Ile Asp Met Tyr Ser Thr Arg Ser 
            260                 265             


<210>  27
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  28
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  29
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  30
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Lys Ala Thr Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Thr Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Val Thr Val Tyr Val Glu Ala Leu Lys Asp 
        35                  40                  45              


Ser Gly Lys Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Val Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu His Glu Gly Thr Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu His Glu Lys Leu Ser Pro Leu Gly Glu Glu Val Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Ser Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Ser Thr Gln 
            260                 265         


<210>  31
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Lys Ala Val Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Asp Pro Gln Ser Ser Trp Asp 
            20                  25                  30          


Arg Val Lys Asp Phe Ala Thr Val Tyr Val Glu Ala Ile Lys Asp Ser 
        35                  40                  45              


Gly Arg Asp Tyr Val Ala Gln Phe Glu Ala Ser Ala Leu Gly Lys Gln 
    50                  55                  60                  


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Thr Leu Ala Ser Thr Leu 
65                  70                  75                  80  


Ser Lys Val Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
                85                  90                  95      


Asn Leu Glu Lys Glu Thr Ala Ser Leu Arg Gln Glu Met His Lys Asp 
            100                 105                 110         


Leu Glu Glu Val Lys Gln Lys Val Gln Pro Tyr Leu Asp Glu Phe Gln 
        115                 120                 125             


Lys Lys Trp His Glu Glu Val Glu Ile Tyr Arg Gln Lys Val Ala Pro 
    130                 135                 140                 


Leu Gly Glu Glu Phe Arg Glu Gly Ala Arg Gln Lys Val Gln Glu Leu 
145                 150                 155                 160 


Gln Asp Lys Leu Ser Pro Leu Ala Gln Glu Leu Arg Asp Arg Ala Arg 
                165                 170                 175     


Ala His Val Glu Thr Leu Arg Gln Gln Leu Ala Pro Tyr Ser Asp Asp 
            180                 185                 190         


Leu Arg Gln Arg Leu Thr Ala Arg Leu Glu Ala Leu Lys Glu Gly Gly 
        195                 200                 205             


Gly Ser Leu Ala Glu Tyr His Ala Lys Ala Ser Glu Gln Leu Lys Ala 
    210                 215                 220                 


Leu Gly Glu Lys Ala Lys Pro Val Leu Glu Asp Leu Arg Gln Gly Leu 
225                 230                 235                 240 


Leu Pro Val Leu Glu Ser Leu Lys Val Ser Ile Leu Ala Ala Ile Asp 
                245                 250                 255     


Glu Ala Ser Lys Lys Leu Asn Ala Gln 
            260                 265 


<210>  32
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Lys Ala Trp Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser Gln 
1               5                   10                  15      


Ala Arg His Phe Trp Gln Gln Asp Asp Pro Gln Ser Pro Trp Asp Arg 
            20                  25                  30          


Val Lys Asp Phe Ala Thr Val Tyr Val Asp Ala Ile Lys Asp Ser Gly 
        35                  40                  45              


Arg Asp Tyr Val Ala Gln Phe Glu Ala Ser Ala Leu Gly Lys His Leu 
    50                  55                  60                  


Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Leu Gly Ser Thr Phe Thr 
65                  70                  75                  80  


Lys Val Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn 
                85                  90                  95      


Leu Glu Lys Glu Thr Glu Ala Leu Arg Gln Glu Met Ser Lys Asp Leu 
            100                 105                 110         


Glu Glu Val Lys Lys Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Asn 
        115                 120                 125             


Lys Trp Gln Glu Glu Met Glu Thr Tyr Arg Gln Lys Met Ala Pro Leu 
    130                 135                 140                 


Gly Ala Glu Phe Arg Glu Gly Ala Arg Gln Lys Val Gln Glu Leu Gln 
145                 150                 155                 160 


Glu Lys Leu Ser Pro Leu Ala Glu Glu Leu Arg Asp Arg Leu Arg Ala 
                165                 170                 175     


His Val Glu Ala Leu Arg Gln His Val Ala Pro Tyr Ser Asp Asp Leu 
            180                 185                 190         


Arg Gln Arg Met Ala Ala Arg Phe Glu Ala Leu Lys Glu Gly Gly Gly 
        195                 200                 205             


Ser Leu Ala Glu Tyr Gln Ala Lys Ala Gln Glu Gln Leu Lys Ala Leu 
    210                 215                 220                 


Gly Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu 
225                 230                 235                 240 


Pro Val Leu Glu Asn Leu Lys Val Ser Ile Leu Ala Ala Ile Asp Glu 
                245                 250                 255     


Ala Ser Lys Lys Leu Asn Ala Gln 
            260                 


<210>  33
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Lys Ala Ala Leu Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Gln Ser Pro Trp Asp 
            20                  25                  30          


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Ala Val Lys Asp Ser 
        35                  40                  45              


Gly Arg Asp Tyr Val Ala Gln Phe Glu Ala Ser Ala Leu Gly Lys Gln 
    50                  55                  60                  


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Leu Ser Ser Thr Val 
65                  70                  75                  80  


Thr Lys Leu Arg Glu Gln Ile Gly Pro Val Thr Gln Glu Phe Trp Asp 
                85                  90                  95      


Asn Leu Glu Lys Glu Thr Glu Val Leu Arg Gln Glu Met Ser Lys Asp 
            100                 105                 110         


Leu Glu Glu Val Lys Gln Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
        115                 120                 125             


Lys Lys Trp Gln Glu Glu Val Glu Leu Tyr Arg Gln Lys Val Ala Pro 
    130                 135                 140                 


Leu Gly Ser Glu Leu Arg Glu Gly Ala Arg Gln Lys Leu Gln Glu Leu 
145                 150                 155                 160 


Gln Glu Lys Leu Ser Pro Leu Ala Glu Glu Leu Arg Asp Arg Ala Arg 
                165                 170                 175     


Thr His Val Asp Ala Leu Arg Ala Gln Leu Ala Pro Tyr Ser Asp Asp 
            180                 185                 190         


Leu Arg Glu Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Gly Gly 
        195                 200                 205             


Gly Ala Ser Leu Ala Glu Tyr His Ala Arg Ala Ser Glu Gln Leu Ser 
    210                 215                 220                 


Ala Leu Gly Glu Lys Ala Arg Pro Ala Leu Glu Asp Leu Arg Gln Gly 
225                 230                 235                 240 


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Leu Leu Ala Ala Ile 
                245                 250                 255     


Asp Glu Ala Thr Lys Lys Leu Asn Ala Gln 
            260                 265     


<210>  34
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Lys Ala Val Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Arg Asp Glu Pro Arg Ser Ser Trp Asp 
            20                  25                  30          


Lys Ile Lys Asp Phe Ala Thr Val Tyr Val Asp Thr Val Lys Asp Ser 
        35                  40                  45              


Gly Arg Glu Tyr Val Ala Gln Phe Glu Ala Ser Ala Phe Gly Lys Gln 
    50                  55                  60                  


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Leu Ser Ser Thr Val 
65                  70                  75                  80  


Ser Lys Leu Gln Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
                85                  90                  95      


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Glu Glu Met Asn Lys Asp 
            100                 105                 110         


Leu Gln Glu Val Arg Gln Lys Val Gln Pro Tyr Leu Asp Glu Phe Gln 
        115                 120                 125             


Lys Lys Trp Gln Glu Glu Val Glu Arg Tyr Arg Gln Lys Val Glu Pro 
    130                 135                 140                 


Leu Gly Ala Glu Leu Arg Glu Ser Ala Arg Gln Lys Leu Thr Glu Leu 
145                 150                 155                 160 


Gln Glu Lys Leu Ser Pro Leu Ala Glu Glu Leu Arg Asp Ser Ala Arg 
                165                 170                 175     


Thr His Val Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Ala Ser Val 
            180                 185                 190         


Gln Asn Val Leu Asp Glu Ala Thr Lys Lys Leu Asn Thr Gln 
        195                 200                 205     


<210>  35
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Lys Ala Val Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Gln Ser Ser Trp Asp 
            20                  25                  30          


Arg Val Arg Asp Leu Ala Asn Val Tyr Val Asp Ala Val Lys Glu Ser 
        35                  40                  45              


Gly Arg Glu Tyr Val Ser Gln Leu Glu Ala Ser Ala Leu Gly Lys Gln 
    50                  55                  60                  


Leu Asn Leu Lys Leu Val Asp Asn Trp Asp Thr Leu Gly Ser Thr Phe 
65                  70                  75                  80  


Gln Lys Val His Glu His Leu Gly Pro Val Ala Gln Glu Phe Trp Glu 
                85                  90                  95      


Lys Leu Glu Lys Glu Thr Glu Glu Leu Arg Arg Glu Ile Asn Lys Asp 
            100                 105                 110         


Leu Glu Asp Val Arg Gln Lys Thr Gln Pro Phe Leu Asp Glu Ile Gln 
        115                 120                 125             


Lys Lys Trp Gln Glu Asp Leu Glu Arg Tyr Arg Gln Lys Val Glu Pro 
    130                 135                 140                 


Leu Ser Ala Gln Leu Arg Glu Gly Ala Arg Gln Lys Leu Met Glu Leu 
145                 150                 155                 160 


Gln Glu Gln Val Thr Pro Leu Gly Glu Asp Leu Arg Asp Ser Val Arg 
                165                 170                 175     


Ala Tyr Ala Asp Thr Leu Arg Thr Gln Leu Ala Pro Tyr Ser Glu Gln 
            180                 185                 190         


Met Arg Lys Thr Leu Gly Ala Arg Leu Glu Ala Ile Lys Glu Gly Gly 
        195                 200                 205             


Ser Ala Ser Leu Ala Glu Tyr His Ala Lys Ala Ser Glu Gln Leu Ser 
    210                 215                 220                 


Ala Leu Gly Glu Lys Ala Lys Pro Val Leu Glu Asp Ile His Gln Gly 
225                 230                 235                 240 


Leu Met Pro Met Trp Glu Ser Phe Lys Thr Gly Val Leu Asn Val Ile 
                245                 250                 255     


Asp Glu Ala Ala Lys Lys Leu Thr Ala 
            260                 265 


<210>  36
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Ala Val Val Leu Ala Val Ala Leu Val Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Trp His Val Trp Gln Gln Asp Glu Pro Gln Ser Gln Trp Asp 
            20                  25                  30          


Lys Val Lys Asp Phe Ala Asn Val Tyr Val Asp Ala Val Lys Asp Ser 
        35                  40                  45              


Gly Arg Asp Tyr Val Ser Gln Phe Glu Ser Ser Ser Leu Gly Gln Gln 
    50                  55                  60                  


Leu Asn Leu Asn Leu Leu Glu Asn Trp Asp Thr Leu Gly Ser Thr Val 
65                  70                  75                  80  


Ser Gln Leu Gln Glu Arg Leu Gly Pro Leu Thr Arg Asp Phe Trp Asp 
                85                  90                  95      


Asn Leu Glu Lys Glu Thr Asp Trp Val Arg Gln Glu Met Asn Lys Asp 
            100                 105                 110         


Leu Glu Glu Val Lys Gln Lys Val Gln Pro Tyr Leu Asp Glu Phe Gln 
        115                 120                 125             


Lys Lys Trp Lys Glu Asp Val Glu Leu Tyr Arg Gln Lys Val Ala Pro 
    130                 135                 140                 


Leu Gly Ala Glu Leu Gln Glu Ser Ala Arg Gln Lys Leu Gln Glu Leu 
145                 150                 155                 160 


Gln Gly Arg Leu Ser Pro Val Ala Glu Glu Phe Arg Asp Arg Met Arg 
                165                 170                 175     


Thr His Val Asp Ser Leu Arg Thr Gln Leu Ala Pro His Ser Glu Gln 
            180                 185                 190         


Met Arg Glu Ser Leu Ala Gln Arg Leu Ala Glu Leu Lys Ser Asn Pro 
        195                 200                 205             


Thr Leu Asn Glu Tyr His Thr Arg Ala Lys Thr His Leu Lys Thr Leu 
    210                 215                 220                 


Gly Glu Lys Ala Arg Pro Ala Leu Glu Asp Leu Arg His Ser Leu Met 
225                 230                 235                 240 


Pro Met Leu Glu Thr Leu Lys Thr Lys Ala Gln Ser Val Ile Asp Lys 
                245                 250                 255     


Ala Ser Glu Thr Leu Thr Ala Gln 
            260                 


<210>  37
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Lys Ala Ala Val Leu Ala Val Ala Leu Val Phe Leu Thr Gly Cys 
1               5                   10                  15      


Gln Ala Trp Glu Phe Trp Gln Gln Asp Glu Pro Gln Ser Gln Trp Asp 
            20                  25                  30          


Arg Val Lys Asp Phe Ala Thr Val Tyr Val Asp Ala Val Lys Asp Ser 
        35                  40                  45              


Gly Arg Asp Tyr Val Ser Gln Phe Glu Ser Ser Thr Leu Gly Lys Gln 
    50                  55                  60                  


Leu Asn Leu Asn Leu Leu Asp Asn Trp Asp Thr Leu Gly Ser Thr Val 
65                  70                  75                  80  


Gly Arg Leu Gln Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Ala 
                85                  90                  95      


Asn Leu Glu Lys Glu Thr Asp Trp Leu Arg Asn Glu Met Asn Lys Asp 
            100                 105                 110         


Leu Glu Asn Val Lys Gln Lys Met Gln Pro His Leu Asp Glu Phe Gln 
        115                 120                 125             


Glu Lys Trp Asn Glu Glu Val Glu Ala Tyr Arg Gln Lys Leu Glu Pro 
    130                 135                 140                 


Leu Gly Thr Glu Leu His Lys Asn Ala Lys Glu Met Gln Arg His Leu 
145                 150                 155                 160 


Lys Val Val Ala Glu Glu Phe Arg Asp Arg Met Arg Val Asn Ala Asp 
                165                 170                 175     


Ala Leu Arg Ala Lys Phe Gly Leu Tyr Ser Asp Gln Met Arg Glu Asn 
            180                 185                 190         


Leu Ala Gln Arg Leu Thr Glu Ile Arg Asn His Pro Thr Leu Ile Glu 
        195                 200                 205             


Tyr His Thr Lys Ala Gly Asp His Leu Arg Thr Leu Gly Glu Lys Ala 
    210                 215                 220                 


Lys Pro Ala Leu Asp Asp Leu Gly Gln Gly Leu Met Pro Val Leu Glu 
225                 230                 235                 240 


Ala Trp Lys Ala Lys Ile Met Ser Met Ile Asp Glu Ala Lys Lys Lys 
                245                 250                 255     


Leu Asn Ala 
            


<210>  38
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  38

Asp Glu Ala Lys Ser Tyr Trp Asp Gln Ile Lys Asp Met Leu Thr Val 
1               5                   10                  15      


Tyr Val Asp Thr Ala Lys Asp Ser Gly Lys Asp Tyr Leu Thr Ser Leu 
            20                  25                  30          


Asp Thr Ser Ala Leu Gly Gln Gln Leu Asn Lys Lys Leu Ala Asp Asn 
        35                  40                  45              


Trp Asp Thr Val Ser Ser Ala Leu Leu Lys Ala Arg Glu Gln Met Lys 
    50                  55                  60                  


Pro Ile Ala Met Glu Phe Trp Gly Asn Leu Glu Lys Asp Thr Glu Gly 
65                  70                  75                  80  


Leu Arg Gln Thr Val Ser Lys Asp Leu Glu Leu Val Lys Glu Lys Val 
                85                  90                  95      


Gln Pro Tyr Leu Asp Ser Phe Gln Lys Lys Val Glu Glu Glu Leu Glu 
            100                 105                 110         


Leu Tyr Arg Gln Lys Val Ala Pro Leu Ser Ala Glu Trp Arg Glu Gln 
        115                 120                 125             


Ala Arg Gln Lys Ala Gln Glu Leu Gln Gln Lys Ala Gly Glu Leu Gly 
    130                 135                 140                 


Gln Gln His Arg Asp Arg Val Arg Thr His Val Asp Ala Leu Arg Thr 
145                 150                 155                 160 


Asp Leu Ala Pro Tyr Gly Glu Glu Ala Arg Lys Leu Leu Leu Gln Arg 
                165                 170                 175     


Leu Gln Asp Ile Lys Ala Lys Ser Gly Asp Leu Ala Glu Tyr Gln Thr 
            180                 185                 190         


Lys Leu Ser Glu His Leu Lys Ser Phe Gly Glu Lys Ala Gln Pro Thr 
        195                 200                 205             


Leu Gln Asp Leu Arg His Gly Leu Glu Pro Leu Trp Glu Gly Ile Lys 
    210                 215                 220                 


Ala Gly Ala Met Ser Met Leu Glu Glu Leu Gly Lys Lys Leu Asn Ser 
225                 230                 235                 240 


Gln 
    


<210>  39
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Arg Gly Val Leu Val Thr Leu Ala Val Leu Phe Leu Thr Gly Thr 
1               5                   10                  15      


Gln Ala Arg Ser Phe Trp Gln His Asp Glu Pro Gln Thr Pro Leu Asp 
            20                  25                  30          


Arg Ile Arg Asp Met Val Asp Val Tyr Leu Glu Thr Val Lys Ala Ser 
        35                  40                  45              


Gly Lys Asp Ala Ile Ala Gln Phe Glu Ser Ser Ala Val Gly Lys Gln 
    50                  55                  60                  


Leu Asp Leu Lys Leu Ala Asp Asn Leu Asp Thr Leu Ser Ala Ala Ala 
65                  70                  75                  80  


Ala Lys Leu Arg Glu Asp Met Ala Pro Tyr Tyr Lys Glu Val Arg Glu 
                85                  90                  95      


Met Trp Leu Lys Asp Thr Glu Ala Leu Arg Ala Glu Leu Thr Lys Asp 
            100                 105                 110         


Leu Glu Glu Val Lys Glu Lys Ile Arg Pro Phe Leu Asp Gln Phe Ser 
        115                 120                 125             


Ala Lys Trp Thr Glu Glu Leu Glu Gln Tyr Arg Gln Arg Leu Thr Pro 
    130                 135                 140                 


Val Ala Gln Glu Leu Lys Glu Leu Thr Lys Gln Lys Val Glu Leu Met 
145                 150                 155                 160 


Gln Ala Lys Leu Thr Pro Val Ala Glu Glu Ala Arg Asp Arg Leu Arg 
                165                 170                 175     


Gly His Val Glu Glu Leu Arg Lys Asn Leu Ala Pro Tyr Ser Asp Glu 
            180                 185                 190         


Leu Arg Gln Lys Leu Ser Gln Lys Leu Glu Glu Ile Arg Glu Lys Gly 
        195                 200                 205             


Ile Pro Gln Ala Ser Glu Tyr Gln Ala Lys Val Met Glu Gln Leu Ser 
    210                 215                 220                 


Asn Leu Arg Glu Lys Met Thr Pro Leu Val Gln Glu Phe Arg Glu Arg 
225                 230                 235                 240 


Leu Thr Pro Tyr Ala Glu Asn Leu Lys Asn Arg Leu Ile Ser Phe Leu 
                245                 250                 255     


Asp Glu Leu Gln Lys Ser Val Ala 
            260                 


<210>  40
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Arg Gly Val Leu Val Thr Leu Ala Val Leu Phe Leu Thr Gly Thr 
1               5                   10                  15      


Gln Ala Arg Ser Phe Trp Gln His Asp Asp Pro Gln Thr Pro Leu Asp 
            20                  25                  30          


Arg Ile Arg Asp Met Leu Asp Val Tyr Leu Glu Thr Val Lys Ala Ser 
        35                  40                  45              


Gly Lys Asp Ala Ile Ser Gln Phe Glu Ser Ser Ala Val Gly Lys Gln 
    50                  55                  60                  


Leu Asp Leu Lys Leu Ala Asp Asn Leu Asp Thr Leu Ser Ala Ala Ala 
65                  70                  75                  80  


Ala Lys Leu Arg Glu Asp Met Thr Pro Tyr Tyr Arg Glu Val Arg Glu 
                85                  90                  95      


Met Trp Leu Lys Asp Thr Glu Ala Leu Arg Ala Glu Leu Thr Lys Asp 
            100                 105                 110         


Leu Glu Glu Val Lys Glu Lys Ile Arg Pro Phe Leu Asp Gln Phe Ser 
        115                 120                 125             


Ala Lys Trp Thr Glu Glu Val Glu Gln Tyr Arg Gln Arg Leu Ala Pro 
    130                 135                 140                 


Val Ala Gln Glu Leu Lys Asp Leu Thr Lys Gln Lys Val Glu Leu Met 
145                 150                 155                 160 


Gln Ala Lys Leu Thr Pro Val Ala Glu Glu Val Arg Asp Arg Leu Arg 
                165                 170                 175     


Glu Gln Val Glu Glu Leu Arg Lys Asn Leu Ala Pro Tyr Ser Ser Glu 
            180                 185                 190         


Leu Arg Gln Lys Leu Ser Gln Lys Leu Glu Glu Ile Arg Glu Arg Gly 
        195                 200                 205             


Ile Pro Gln Ala Ser Glu Tyr Gln Ala Lys Val Val Glu Gln Leu Ser 
    210                 215                 220                 


Asn Leu Arg Glu Lys Met Thr Pro Leu Val Gln Glu Phe Lys Glu Arg 
225                 230                 235                 240 


Leu Thr Pro Tyr Ala Glu Asn Leu Lys Asn Arg Leu Ile Asp Leu Leu 
                245                 250                 255     


Asp Glu Val Gln Lys Thr Met Ala 
            260                 


<210>  41
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Arg Val Val Val Val Thr Leu Ala Leu Leu Phe Leu Thr Gly Thr 
1               5                   10                  15      


Gln Ala Arg Tyr Phe Trp Gln His Asp Glu Pro Gln Ala Pro Leu Asp 
            20                  25                  30          


Arg Leu Arg Asp Leu Val Asp Val Tyr Leu Glu Thr Val Lys Ala Ser 
        35                  40                  45              


Gly Lys Asp Ala Ile Ala Gln Phe Glu Ala Ser Ala Val Gly Lys Gln 
    50                  55                  60                  


Leu Asp Leu Lys Leu Ala Asp Asn Leu Asp Thr Leu Gly Ala Ala Ala 
65                  70                  75                  80  


Ala Lys Leu Arg Glu Asp Met Ala Pro Tyr Tyr Lys Glu Val Arg Glu 
                85                  90                  95      


Met Trp Leu Lys Asp Thr Glu Ser Leu Arg Ala Glu Leu Thr Lys Asp 
            100                 105                 110         


Leu Glu Glu Val Lys Glu Lys Ile Arg Pro Phe Leu Asp Gln Phe Ser 
        115                 120                 125             


Ala Lys Trp Thr Glu Glu Leu Glu Gln Tyr Arg Gln Arg Leu Ala Pro 
    130                 135                 140                 


Val Ala Glu Glu Leu Lys Glu Leu Thr Lys Gln Lys Val Glu Leu Met 
145                 150                 155                 160 


Gln Gln Lys Leu Thr Pro Val Ala Glu Glu Ala Arg Asp Arg Leu Arg 
                165                 170                 175     


Gly His Val Glu Glu Leu Arg Lys Asn Leu Ala Pro Tyr Ser Asp Glu 
            180                 185                 190         


Leu Arg Gln Lys Leu Ser Gln Lys Leu Glu Glu Ile Arg Glu Lys Gly 
        195                 200                 205             


Ile Pro Gln Ala Ala Glu Tyr Gln Ala Lys Val Val Glu Gln Leu Ser 
    210                 215                 220                 


Asn Leu Arg Glu Lys Met Thr Pro Leu Val Gln Asp Phe Lys Glu Arg 
225                 230                 235                 240 


Leu Thr Pro Tyr Ala Glu Asn Leu Lys Thr Arg Phe Ile Ser Leu Leu 
                245                 250                 255     


Asp Glu Leu Gln Lys Thr Val Ala 
            260                 


<210>  42
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Lys Phe Leu Ala Leu Ala Leu Thr Ile Leu Leu Ala Ala Gly Thr 
1               5                   10                  15      


Gln Ala Phe Pro Met Gln Ala Asp Ala Pro Ser Gln Leu Glu His Val 
            20                  25                  30          


Lys Ala Ala Leu Ser Met Tyr Ile Ala Gln Val Lys Leu Thr Ala Gln 
        35                  40                  45              


Arg Ser Ile Asp Leu Leu Asp Asp Thr Glu Tyr Lys Glu Tyr Lys Met 
    50                  55                  60                  


Gln Leu Thr Gln Ser Leu Asp Asn Leu Gln Gln Tyr Ala Asp Ala Thr 
65                  70                  75                  80  


Ser Gln Ser Leu Ala Pro Tyr Ser Glu Ala Phe Gly Thr Gln Leu Thr 
                85                  90                  95      


Asp Ala Thr Ala Ala Val Arg Ala Glu Val Met Lys Asp Val Glu Glu 
            100                 105                 110         


Leu Arg Ser Gln Leu Glu Pro Lys Arg Ala Glu Leu Lys Glu Val Leu 
        115                 120                 125             


Asp Lys His Ile Asp Glu Tyr Arg Lys Lys Leu Glu Pro Leu Ile Lys 
    130                 135                 140                 


Glu His Ile Glu Leu Arg Arg Thr Glu Met Glu Ala Phe Arg Ala Lys 
145                 150                 155                 160 


Met Glu Pro Ile Val Glu Glu Leu Arg Ala Lys Val Ala Ile Asn Val 
                165                 170                 175     


Glu Glu Thr Lys Thr Lys Leu Met Pro Ile Val Glu Ile Val Arg Ala 
            180                 185                 190         


Lys Leu Thr Glu Arg Leu Glu Glu Leu Arg Thr Leu Ala Ala Pro Tyr 
        195                 200                 205             


Ala Glu Glu Tyr Lys Glu Gln Met Ile Lys Ala Val Gly Glu Val Arg 
    210                 215                 220                 


Glu Lys Val Ser Pro Leu Ser Glu Asp Phe Lys Gly Gln Val Gly Pro 
225                 230                 235                 240 


Ala Ala Glu Gln Ala Lys Gln Lys Leu Leu Ala Phe Tyr Glu Thr Ile 
                245                 250                 255     


Ser Gln Ala Met Lys Ala 
            260         


<210>  43
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Lys Phe Leu Ala Leu Ala Leu Thr Ile Leu Leu Ala Ala Ala Thr 
1               5                   10                  15      


Gln Ala Val Pro Met Gln Ala Asp Ala Pro Ser Gln Leu Glu His Val 
            20                  25                  30          


Lys Val Ala Met Met Glu Tyr Met Ala Gln Val Lys Glu Thr Gly Gln 
        35                  40                  45              


Arg Ser Ile Asp Leu Leu Asp Asp Thr Glu Phe Lys Glu Tyr Lys Val 
    50                  55                  60                  


Gln Leu Ser Gln Ser Leu Asp Asn Leu Gln Gln Tyr Ala Gln Thr Thr 
65                  70                  75                  80  


Ser Gln Ser Leu Ala Pro Tyr Ser Glu Ala Phe Gly Ala Gln Leu Thr 
                85                  90                  95      


Asp Ala Ala Ala Ala Val Arg Ala Glu Val Met Lys Asp Val Glu Asp 
            100                 105                 110         


Val Arg Thr Gln Leu Glu Pro Lys Arg Ala Glu Leu Lys Glu Val Leu 
        115                 120                 125             


Asp Lys His Ile Asp Glu Tyr Arg Lys Lys Leu Glu Pro Leu Ile Lys 
    130                 135                 140                 


Glu Ile Val Glu Gln Arg Arg Thr Glu Leu Glu Ala Phe Arg Val Lys 
145                 150                 155                 160 


Met Glu Pro Val Val Glu Glu Met Arg Ala Lys Val Ser Thr Asn Val 
                165                 170                 175     


Glu Glu Thr Lys Ala Lys Leu Met Pro Ile Val Glu Thr Val Arg Ala 
            180                 185                 190         


Lys Leu Thr Glu Arg Leu Glu Glu Leu Arg Thr Leu Ala Ala Pro Tyr 
        195                 200                 205             


Ala Glu Glu Tyr Lys Glu Gln Met Phe Lys Ala Val Gly Glu Val Arg 
    210                 215                 220                 


Glu Lys Val Gly Pro Leu Thr Asn Asp Phe Lys Gly Gln Val Gly Pro 
225                 230                 235                 240 


Ala Ala Glu Gln Ala Lys Glu Lys Leu Met Asp Phe Tyr Glu Thr Ile 
                245                 250                 255     


Ser Gln Ala Met Lys Ala 
            260         


<210>  44
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Lys Phe Leu Val Leu Ala Leu Thr Ile Leu Leu Ala Ala Gly Thr 
1               5                   10                  15      


Gln Ala Phe Pro Met Gln Ala Asp Ala Pro Ser Gln Leu Glu His Val 
            20                  25                  30          


Lys Ala Ala Leu Asn Met Tyr Ile Ala Gln Val Lys Leu Thr Ala Gln 
        35                  40                  45              


Arg Ser Ile Asp Leu Leu Asp Asp Thr Glu Tyr Lys Glu Tyr Lys Met 
    50                  55                  60                  


Gln Leu Ser Gln Ser Leu Asp Asn Leu Gln Gln Phe Ala Asp Ser Thr 
65                  70                  75                  80  


Ser Lys Ser Trp Pro Pro Thr Pro Arg Ser Ser Ala Pro Ser Cys Asp 
                85                  90                  95      


Ala Thr Ala Thr Val Arg Ala Glu Val Met Lys Asp Val Glu Asp Val 
            100                 105                 110         


Arg Thr Gln Leu Glu Pro Lys Arg Ala Glu Leu Thr Glu Val Leu Asn 
        115                 120                 125             


Lys His Ile Asp Glu Tyr Arg Lys Lys Leu Glu Pro Leu Ile Lys Gln 
    130                 135                 140                 


His Ile Glu Leu Arg Arg Thr Glu Met Asp Ala Phe Arg Ala Lys Ile 
145                 150                 155                 160 


Asp Pro Val Val Glu Glu Met Arg Ala Lys Val Ala Val Asn Val Glu 
                165                 170                 175     


Glu Thr Lys Thr Lys Leu Met Pro Ile Val Glu Ile Val Arg Ala Lys 
            180                 185                 190         


Leu Thr Glu Arg Leu Glu Glu Leu Arg Thr Leu Ala Ala Pro Tyr Ala 
        195                 200                 205             


Glu Glu Tyr Lys Glu Gln Met Phe Lys Ala Val Gly Glu Val Arg Glu 
    210                 215                 220                 


Lys Val Ala Pro Leu Ser Glu Asp Phe Lys Ala Arg Trp Ala Pro Pro 
225                 230                 235                 240 


Pro Arg Arg Pro Ser Lys Ser Ser Trp Leu Ser Thr Arg Pro Ser Ala 
                245                 250                 255     


Arg Pro 
        


<210>  45
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Lys Phe Val Ala Leu Ala Leu Thr Leu Leu Leu Ala Leu Gly Ser 
1               5                   10                  15      


Gln Ala Asn Leu Phe Gln Ala Asp Ala Pro Thr Gln Leu Glu His Tyr 
            20                  25                  30          


Lys Ala Ala Ala Leu Val Tyr Leu Asn Gln Val Lys Asp Gln Ala Glu 
        35                  40                  45              


Lys Ala Leu Asp Asn Leu Asp Gly Thr Asp Tyr Glu Gln Tyr Lys Leu 
    50                  55                  60                  


Gln Leu Ser Glu Ser Leu Thr Lys Leu Gln Glu Tyr Ala Gln Thr Thr 
65                  70                  75                  80  


Ser Gln Ala Leu Thr Pro Tyr Ala Glu Thr Ile Ser Thr Gln Leu Met 
                85                  90                  95      


Glu Asn Thr Lys Gln Leu Arg Glu Arg Val Met Thr Asp Val Glu Asp 
            100                 105                 110         


Leu Arg Ser Lys Leu Glu Pro His Arg Ala Glu Leu Tyr Thr Ala Leu 
        115                 120                 125             


Gln Lys His Ile Asp Glu Tyr Arg Glu Lys Leu Glu Pro Val Phe Gln 
    130                 135                 140                 


Glu Tyr Ser Ala Leu Asn Arg Gln Asn Ala Glu Gln Leu Arg Ala Lys 
145                 150                 155                 160 


Leu Glu Pro Leu Met Asp Asp Ile Arg Lys Ala Phe Glu Ser Asn Ile 
                165                 170                 175     


Glu Glu Thr Lys Ser Lys Val Val Pro Met Val Glu Ala Val Arg Thr 
            180                 185                 190         


Lys Leu Thr Glu Arg Leu Glu Asp Leu Arg Thr Met Ala Ala Pro Tyr 
        195                 200                 205             


Ala Glu Glu Tyr Lys Glu Gln Leu Val Lys Ala Val Glu Glu Ala Arg 
    210                 215                 220                 


Glu Lys Ile Ala Pro His Thr Gln Asp Leu Gln Thr Arg Met Glu Pro 
225                 230                 235                 240 


Tyr Met Glu Asn Val Arg Thr Thr Phe Ala Gln Met Tyr Glu Thr Ile 
                245                 250                 255     


Ala Lys Ala Ile Gln Ala 
            260         


<210>  46
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Lys Phe Ala Ala Leu Ala Leu Ala Leu Leu Leu Ala Val Gly Ser 
1               5                   10                  15      


His Ala Ala Ser Met Gln Ala Asp Ala Pro Ser Gln Leu Asp His Ala 
            20                  25                  30          


Arg Ala Val Leu Asp Val Tyr Leu Thr Gln Val Lys Asp Met Ser Leu 
        35                  40                  45              


Arg Ala Val Asn Gln Leu Asp Asp Pro Gln Tyr Ala Glu Phe Lys Thr 
    50                  55                  60                  


Asn Leu Ala Gln Arg Ile Glu Glu Met Tyr Thr Gln Ile Lys Thr Leu 
65                  70                  75                  80  


Gln Gly Ser Val Ser Pro Met Thr Asp Ser Phe Tyr Asn Thr Val Met 
                85                  90                  95      


Glu Val Thr Lys Asp Thr Arg Glu Ser Leu Asn Val Asp Leu Glu Ala 
            100                 105                 110         


Leu Lys Ser Ser Leu Ala Pro Gln Asn Glu Gln Leu Lys Gln Val Ile 
        115                 120                 125             


Glu Lys His Leu Asn Asp Tyr Arg Thr Leu Leu Thr Pro Ile Tyr Asn 
    130                 135                 140                 


Asp Tyr Lys Thr Lys His Asp Glu Glu Met Ala Ala Leu Lys Thr Arg 
145                 150                 155                 160 


Leu Glu Pro Val Met Glu Glu Leu Arg Thr Lys Ile Gln Ala Asn Val 
                165                 170                 175     


Glu Glu Thr Lys Ala Val Leu Met Pro Met Val Glu Thr Val Arg Thr 
            180                 185                 190         


Lys Val Thr Glu Arg Leu Glu Ser Leu Arg Glu Val Val Gln Pro Tyr 
        195                 200                 205             


Val Gln Glu Tyr Lys Glu Gln Met Lys Gln Met Tyr Asp Gln Ala Gln 
    210                 215                 220                 


Thr Val Asp Thr Asp Ala Leu Arg Thr Lys Ile Thr Pro Leu Val Glu 
225                 230                 235                 240 


Glu Ile Lys Val Lys Met Asn Ala Ile Phe Glu Ile Ile Ala Ala Ser 
                245                 250                 255     


Val Thr Lys Ser 
            260 


<210>  47
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Phe Leu Lys Ala Val Val Leu Thr Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Gly Ala Arg Ala Glu Val Ser Ala Asp Gln Val Ala Thr Val Met Trp 
            20                  25                  30          


Asp Tyr Phe Ser Gln Leu Ser Asn Asn Ala Lys Glu Ala Val Glu His 
        35                  40                  45              


Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu Asn Ala Leu Phe Gln Asp 
    50                  55                  60                  


Lys Leu Gly Glu Val Asn Thr Tyr Ala Gly Asp Leu Gln Lys Lys Leu 
65                  70                  75                  80  


Val Pro Phe Ala Thr Glu Leu His Glu Arg Leu Ala Lys Asp Ser Glu 
                85                  90                  95      


Lys Leu Lys Glu Glu Ile Gly Lys Glu Leu Glu Glu Leu Arg Ala Arg 
            100                 105                 110         


Leu Leu Pro His Ala Asn Glu Val Ser Gln Lys Ile Gly Asp Asn Leu 
        115                 120                 125             


Arg Glu Leu Gln Gln Arg Leu Glu Pro Tyr Ala Asp Gln Leu Arg Thr 
    130                 135                 140                 


Gln Val Asn Thr Gln Ala Glu Gln Leu Arg Arg Gln Leu Thr Pro Tyr 
145                 150                 155                 160 


Ala Gln Arg Met Glu Arg Val Leu Arg Glu Asn Ala Asp Ser Leu Gln 
                165                 170                 175     


Ala Ser Leu Arg Pro His Ala Asp Glu Leu Lys Ala Lys Ile Asp Gln 
            180                 185                 190         


Asn Val Glu Glu Leu Lys Gly Arg Leu Thr Pro Tyr Ala Asp Glu Phe 
        195                 200                 205             


Lys Val Lys Ile Asp Gln Thr Val Glu Glu Leu Arg Arg Ser Leu Ala 
    210                 215                 220                 


Pro Tyr Ala Gln Asp Thr Gln Glu Lys Leu Asn His Gln Leu Glu Gly 
225                 230                 235                 240 


Leu Thr Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys Ala Arg Ile 
                245                 250                 255     


Ser Ala Ser Ala Glu Glu Leu Arg Gln Arg Leu Ala Pro Leu Ala Glu 
            260                 265                 270         


Asp Val Arg Gly Asn Leu Lys Gly Asn Thr Glu Gly Leu Gln Lys Ser 
        275                 280                 285             


Leu Ala Glu Leu Gly Gly His Leu Asp Gln Gln Val Glu Glu Phe Arg 
    290                 295                 300                 


Arg Arg Val Glu Pro Tyr Gly Glu Asn Phe Asn Lys Ala Leu Val Gln 
305                 310                 315                 320 


Gln Met Glu Gln Leu Arg Gln Lys Leu Gly Pro His Ala Gly Asp Val 
                325                 330                 335     


Glu Gly His Leu Ser Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 
            340                 345                 350         


Ser Phe Phe Ser Thr Phe Lys Glu Lys Glu Ser Gln Asp Lys Thr Leu 
        355                 360                 365             


Ser Leu Pro Glu Leu Glu Gln Gln Gln Glu Gln Gln Gln Glu Gln Gln 
    370                 375                 380                 


Gln Glu Gln Val Gln Met Leu Ala Pro Leu Glu Ser 
385                 390                 395     


<210>  48
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Phe Leu Lys Ala Val Val Leu Thr Leu Ala Leu Val Ala Val Thr 
1               5                   10                  15      


Gly Ala Arg Ala Glu Val Ser Ala Asp Gln Val Ala Thr Val Met Trp 
            20                  25                  30          


Asp Tyr Phe Ser Gln Leu Ser Ser Asn Ala Lys Glu Ala Val Glu His 
        35                  40                  45              


Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu Asn Ala Leu Phe Gln Asp 
    50                  55                  60                  


Lys Leu Gly Glu Val Asn Thr Tyr Ala Gly Asp Leu Gln Lys Lys Leu 
65                  70                  75                  80  


Val Pro Phe Ala Thr Glu Leu His Glu Arg Leu Ala Lys Asp Ser Glu 
                85                  90                  95      


Lys Leu Lys Glu Glu Ile Arg Lys Glu Leu Glu Glu Val Arg Ala Arg 
            100                 105                 110         


Leu Leu Pro His Ala Asn Glu Val Ser Gln Lys Ile Gly Glu Asn Val 
        115                 120                 125             


Arg Glu Leu Gln Gln Arg Leu Glu Pro Tyr Thr Asp Gln Leu Arg Thr 
    130                 135                 140                 


Gln Val Asn Thr Gln Thr Glu Gln Leu Arg Arg Gln Leu Thr Pro Tyr 
145                 150                 155                 160 


Ala Gln Arg Met Glu Arg Val Leu Arg Glu Asn Ala Asp Ser Leu Gln 
                165                 170                 175     


Thr Ser Leu Arg Pro His Ala Asp Gln Leu Lys Ala Lys Ile Asp Gln 
            180                 185                 190         


Asn Val Glu Glu Leu Lys Glu Arg Leu Thr Pro Tyr Ala Asp Glu Phe 
        195                 200                 205             


Lys Val Lys Ile Asp Gln Thr Val Glu Glu Leu Arg Arg Ser Leu Ala 
    210                 215                 220                 


Pro Tyr Ala Gln Asp Ala Gln Glu Lys Leu Asn His Gln Leu Glu Gly 
225                 230                 235                 240 


Leu Ala Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys Ala Arg Ile 
                245                 250                 255     


Ser Ala Ser Ala Glu Glu Leu Arg Gln Arg Leu Ala Pro Leu Ala Glu 
            260                 265                 270         


Asp Met Arg Gly Asn Leu Arg Gly Asn Thr Glu Gly Leu Gln Lys Ser 
        275                 280                 285             


Leu Ala Glu Leu Gly Gly His Leu Asp Arg His Val Glu Glu Phe Arg 
    290                 295                 300                 


Leu Arg Val Glu Pro Tyr Gly Glu Asn Phe Asn Lys Ala Leu Val Gln 
305                 310                 315                 320 


Gln Met Glu Gln Leu Arg Gln Lys Leu Gly Pro His Ala Gly Asp Val 
                325                 330                 335     


Glu Gly His Leu Ser Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 
            340                 345                 350         


Ser Phe Phe Ser Thr Phe Lys Glu Lys Glu Ser Gln Asp Asn Thr Leu 
        355                 360                 365             


Ser Leu Pro Glu Pro Glu Gln Gln Arg Glu Gln Gln Gln Glu Gln Gln 
    370                 375                 380                 


Gln Glu Gln Glu Gln Glu Gln Gln Gln Gln Gln Glu Gln Gln Gln Gln 
385                 390                 395                 400 


Gln Glu Gln Gln Arg Glu Gln Gln Gln Gln Glu Gln Gln Gln Glu Gln 
                405                 410                 415     


Gln Gln Glu Gln Val Gln Met Leu Ala Pro Leu Glu Ser 
            420                 425                 


<210>  49
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Phe Leu Lys Ala Ala Val Leu Thr Leu Ala Leu Val Ala Ile Thr 
1               5                   10                  15      


Gly Thr Arg Ala Glu Val Thr Ser Asp Gln Val Ala Asn Val Val Trp 
            20                  25                  30          


Asp Tyr Phe Thr Gln Leu Ser Asn Asn Ala Lys Glu Ala Val Glu Gln 
        35                  40                  45              


Phe Gln Lys Thr Asp Val Thr Gln Gln Leu Ser Thr Leu Phe Gln Asp 
    50                  55                  60                  


Lys Leu Gly Asp Ala Ser Thr Tyr Ala Asp Gly Val His Asn Lys Leu 
65                  70                  75                  80  


Val Pro Phe Val Val Gln Leu Ser Gly His Leu Ala Lys Glu Thr Glu 
                85                  90                  95      


Arg Val Lys Glu Glu Ile Lys Lys Glu Leu Glu Asp Leu Arg Asp Arg 
            100                 105                 110         


Met Met Pro His Ala Asn Lys Val Thr Gln Thr Phe Gly Glu Asn Met 
        115                 120                 125             


Gln Lys Leu Gln Glu His Leu Lys Pro Tyr Ala Val Asp Leu Gln Asp 
    130                 135                 140                 


Gln Ile Asn Thr Gln Thr Gln Glu Met Lys Leu Gln Leu Thr Pro Tyr 
145                 150                 155                 160 


Ile Gln Arg Met Gln Thr Thr Ile Lys Glu Asn Val Asp Asn Leu His 
                165                 170                 175     


Thr Ser Met Met Pro Leu Ala Thr Asn Leu Lys Asp Lys Phe Asn Arg 
            180                 185                 190         


Asn Met Glu Glu Leu Lys Gly His Leu Thr Pro Arg Ala Asn Glu Leu 
        195                 200                 205             


Lys Ala Thr Ile Asp Gln Asn Leu Glu Asp Leu Arg Arg Ser Leu Ala 
    210                 215                 220                 


Pro Leu Thr Val Gly Val Gln Glu Lys Leu Asn His Gln Met Glu Gly 
225                 230                 235                 240 


Leu Ala Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Gln Thr Lys Val 
                245                 250                 255     


Ser Ala Lys Ile Asp Gln Leu Gln Lys Asn Leu Ala Pro Leu Val Glu 
            260                 265                 270         


Asp Val Gln Ser Lys Val Lys Gly Asn Thr Glu Gly Leu Gln Lys Ser 
        275                 280                 285             


Leu Glu Asp Leu Asn Arg Gln Leu Glu Gln Gln Val Glu Glu Phe Arg 
    290                 295                 300                 


Arg Thr Val Glu Pro Met Gly Glu Met Phe Asn Lys Ala Leu Val Gln 
305                 310                 315                 320 


Gln Leu Glu Gln Phe Arg Gln Gln Leu Gly Pro Asn Ser Gly Glu Val 
                325                 330                 335     


Glu Ser His Leu Ser Phe Leu Glu Lys Ser Leu Arg Glu Lys Val Asn 
            340                 345                 350         


Ser Phe Met Ser Thr Leu Glu Lys Lys Gly Ser Pro Asp Gln Pro Gln 
        355                 360                 365             


Ala Leu Pro Leu Pro Glu Gln Ala Gln Glu Gln Ala Gln Glu Gln Ala 
    370                 375                 380                 


Gln Glu Gln Val Gln Pro Lys Pro Leu Glu Ser 
385                 390                 395 


<210>  50
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Ala Arg Ala Glu Val Ser Ala Asp Gln Val Ala Thr Val Met Trp 
1               5                   10                  15      


Asp Tyr Phe Ser Gln Leu Ser Ser Asn Ala Lys Glu Ala Val Glu His 
            20                  25                  30          


Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu Asn Ala Leu Phe Gln Asp 
        35                  40                  45              


Lys Leu Gly Glu Val Asn Thr Tyr Ala Gly Asp Leu Gln Lys Lys Leu 
    50                  55                  60                  


Val Pro Phe Ala Thr Glu Leu His Glu Arg Leu Ala Lys Asp Ser Lys 
65                  70                  75                  80  


Lys Leu Lys Glu Glu Ile Arg Lys Glu Leu Glu Glu Val Arg Ala Arg 
                85                  90                  95      


Leu Leu Pro His Ala Asn Glu Val Ser Gln Lys Ile Gly Glu Asn Val 
            100                 105                 110         


Arg Glu Leu Gln Gln Arg Leu Glu Pro Tyr Thr Asp Gln Leu Arg Thr 
        115                 120                 125             


Gln Val Asn Thr Gln Thr Glu Gln Leu Arg Arg Gln Leu Thr Pro Tyr 
    130                 135                 140                 


Ala Gln Arg Met Glu Arg Val Leu Arg Glu Asn Ala Asp Ser Leu Gln 
145                 150                 155                 160 


Thr Ser Leu Arg Pro His Ala Asp Gln Leu Lys Ala Lys Ile Asp Gln 
                165                 170                 175     


Asn Val Glu Glu Leu Lys Gly Arg Leu Thr Pro Tyr Ala Asp Glu Phe 
            180                 185                 190         


Lys Val Lys Ile Asp Gln Thr Val Glu Glu Leu Arg Arg Ser Leu Ala 
        195                 200                 205             


Pro Tyr Ala Gln Asp Ala Gln Glu Lys Leu Asn His Gln Leu Glu Gly 
    210                 215                 220                 


Leu Ala Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys Ala Arg Ile 
225                 230                 235                 240 


Ser Ala Ser Ala Glu Glu Leu Arg Gln Arg Leu Ala Pro Leu Ala Glu 
                245                 250                 255     


Asp Met Arg Gly Asn Leu Arg Gly Asn Thr Glu Gly Leu Gln Lys Ser 
            260                 265                 270         


Leu Ala Glu Leu Gly Gly His Leu Asp Arg His Val Glu Glu Phe Arg 
        275                 280                 285             


Leu Arg Val Glu Pro Tyr Gly Glu Asn Phe Asn Lys Ala Leu Val Gln 
    290                 295                 300                 


Gln Met Glu Gln Leu Arg Gln Lys Leu Gly Pro His Ala Gly Asp Val 
305                 310                 315                 320 


Glu Gly His Leu Ser Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 
                325                 330                 335     


Ser Phe Phe Ser Thr Phe Lys Glu Lys Glu Ser Gln Asp Asn Thr Leu 
            340                 345                 350         


Ser Leu Pro Glu Pro Glu Gln Gln Gln Glu Gln Gln Gln Glu Gln Glu 
        355                 360                 365             


Gln Gln Gln Glu Gln Gln Glu Glu Gln Gln Gln Gln Glu Gln Gln Gln 
    370                 375                 380                 


Glu Gln Glu Gln Gln Gln Glu Gln Val Gln Met Leu Ala Pro Leu Glu 
385                 390                 395                 400 


Ser 
    


<210>  51
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Phe Leu Lys Ala Val Val Leu Ser Leu Ala Leu Val Ala Val Thr 
1               5                   10                  15      


Gly Ala Arg Ala Glu Val Asn Ala Asp Gln Val Ala Thr Val Met Trp 
            20                  25                  30          


Asp Tyr Phe Ser Gln Leu Gly Ser Asn Ala Lys Lys Ala Val Glu His 
        35                  40                  45              


Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu Asn Thr Leu Phe Gln Asp 
    50                  55                  60                  


Lys Leu Gly Glu Val Asn Thr Tyr Thr Glu Asp Leu Gln Lys Lys Leu 
65                  70                  75                  80  


Val Pro Phe Ala Thr Glu Leu His Glu Arg Leu Thr Lys Asp Ser Glu 
                85                  90                  95      


Lys Leu Lys Glu Glu Ile Arg Arg Glu Leu Glu Glu Leu Arg Ala Arg 
            100                 105                 110         


Leu Leu Pro His Ala Thr Glu Val Ser Gln Lys Ile Gly Asp Asn Val 
        115                 120                 125             


Arg Glu Leu Gln Gln Arg Leu Gly Pro Phe Thr Gly Gly Leu Arg Thr 
    130                 135                 140                 


Gln Val Asn Thr Gln Val Gln Gln Leu Gln Arg Gln Leu Lys Pro Tyr 
145                 150                 155                 160 


Ala Glu Arg Met Glu Ser Val Leu Arg Gln Asn Ile Arg Asn Leu Glu 
                165                 170                 175     


Ala Ser Val Ala Pro Tyr Ala Asp Glu Phe Lys Ala Lys Ile Asp Gln 
            180                 185                 190         


Asn Val Glu Glu Leu Lys Gly Ser Leu Thr Pro Tyr Ala Glu Glu Leu 
        195                 200                 205             


Lys Ala Lys Ile Asp Gln Asn Val Glu Glu Leu Arg Arg Ser Leu Ala 
    210                 215                 220                 


Pro Tyr Ala Gln Asp Val Gln Glu Lys Leu Asn His Gln Leu Glu Gly 
225                 230                 235                 240 


Leu Ala Phe Gln Met Lys Lys Gln Ala Glu Glu Leu Lys Ala Lys Ile 
                245                 250                 255     


Ser Ala Asn Ala Asp Glu Leu Arg Gln Lys Leu Val Pro Val Ala Glu 
            260                 265                 270         


Asn Val His Gly His Leu Lys Gly Asn Thr Glu Gly Leu Gln Lys Ser 
        275                 280                 285             


Leu Leu Glu Leu Arg Ser His Leu Asp Gln Gln Val Glu Glu Phe Arg 
    290                 295                 300                 


Leu Lys Val Glu Pro Tyr Gly Glu Thr Phe Asn Lys Ala Leu Val Gln 
305                 310                 315                 320 


Gln Val Glu Asp Leu Arg Gln Lys Leu Gly Pro Leu Ala Gly Asp Val 
                325                 330                 335     


Glu Gly His Leu Ser Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 
            340                 345                 350         


Thr Phe Phe Ser Thr Leu Lys Glu Glu Ala Ser Gln Gly Gln Ser Gln 
        355                 360                 365             


Ala Leu Pro Ala Gln Glu Lys Ala Gln Ala Pro Leu Glu Gly 
    370                 375                 380         


<210>  52
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Phe Leu Lys Ala Val Val Leu Thr Val Ala Leu Val Ala Ile Thr 
1               5                   10                  15      


Gly Thr Gln Ala Glu Val Thr Ser Asp Gln Val Ala Asn Val Met Trp 
            20                  25                  30          


Asp Tyr Phe Thr Gln Leu Ser Asn Asn Ala Lys Glu Ala Val Glu Gln 
        35                  40                  45              


Leu Gln Lys Thr Asp Val Thr Gln Gln Leu Asn Thr Leu Phe Gln Asp 
    50                  55                  60                  


Lys Leu Gly Asn Ile Asn Thr Tyr Ala Asp Asp Leu Gln Asn Lys Leu 
65                  70                  75                  80  


Val Pro Phe Ala Val Gln Leu Ser Gly His Leu Thr Lys Glu Thr Glu 
                85                  90                  95      


Arg Val Arg Glu Glu Ile Gln Lys Glu Leu Glu Asp Leu Arg Ala Asn 
            100                 105                 110         


Met Met Pro His Ala Asn Lys Val Ser Gln Met Phe Gly Asp Asn Val 
        115                 120                 125             


Gln Lys Leu Gln Glu His Leu Arg Pro Tyr Ala Thr Asp Leu Gln Ala 
    130                 135                 140                 


Gln Ile Asn Ala Gln Thr Gln Asp Met Lys Arg Gln Leu Thr Pro Tyr 
145                 150                 155                 160 


Ile Gln Arg Met Gln Thr Thr Ile Gln Asp Asn Val Glu Asn Leu Gln 
                165                 170                 175     


Ser Ser Met Val Pro Phe Ala Asn Glu Leu Lys Glu Lys Phe Asn Gln 
            180                 185                 190         


Asn Met Glu Gly Leu Lys Gly Gln Leu Thr Pro Arg Ala Asn Glu Leu 
        195                 200                 205             


Lys Ala Thr Ile Asp Gln Asn Leu Glu Asp Leu Arg Ser Arg Leu Ala 
    210                 215                 220                 


Pro Leu Ala Glu Gly Val Gln Glu Lys Leu Asn His Gln Met Glu Gly 
225                 230                 235                 240 


Leu Ala Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Gln Thr Lys Val 
                245                 250                 255     


Ser Thr Asn Ile Asp Gln Leu Gln Lys Asn Leu Ala Pro Leu Val Glu 
            260                 265                 270         


Asp Val Gln Ser Lys Leu Lys Gly Asn Thr Glu Gly Leu Gln Lys Ser 
        275                 280                 285             


Leu Glu Asp Leu Asn Lys Gln Leu Asp Gln Gln Val Glu Val Phe Arg 
    290                 295                 300                 


Arg Ala Val Glu Pro Leu Gly Asp Lys Phe Asn Met Ala Leu Val Gln 
305                 310                 315                 320 


Gln Met Glu Lys Phe Arg Gln Gln Leu Gly Ser Asp Ser Gly Asp Val 
                325                 330                 335     


Glu Ser His Leu Ser Phe Leu Glu Lys Asn Leu Arg Glu Lys Val Ser 
            340                 345                 350         


Ser Phe Met Ser Thr Leu Gln Lys Lys Gly Ser Pro Asp Gln Pro Leu 
        355                 360                 365             


Ala Leu Pro Leu Pro Glu Gln Val Gln Glu Gln Val Gln Glu Gln Val 
    370                 375                 380                 


Gln Pro Lys Pro Leu Glu Ser 
385                 390     


<210>  53
<211>  51
<212>  PRT
<213>  Homo sapiens

<300>
<302>  Trimerising module
<310>  WO 98/56906
<311>  1998-06-11
<312>  1998-12-17
<313>  (1)..(51)

<400>  53

Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val Asn Ala Lys Lys Asp 
1               5                   10                  15      


Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys Ser Arg Leu Asp Thr 
            20                  25                  30          


Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln Gln Ala Leu Gln Thr 
        35                  40                  45              


Val Cys Leu 
    50      


<210>  54
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  54

Ile Val Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe Glu Glu 
1               5                   10                  15      


Leu Lys Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu Leu Lys 
            20                  25                  30          


Glu Gln Gln Ala Leu Gln Thr Val 
        35                  40  


<210>  55
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  55

Cys Asp Leu Pro Gln Thr His Ser Leu 
1               5                   


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hexahistidine tag

<400>  56

His His His His His His 
1               5       


<210>  57
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  57

Met Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser His His His His 
1               5                   10                  15      


His His Gly Ser Val Val Ala Pro Pro Ala Pro Ile Val Asn Ala Lys 
            20                  25                  30          


Lys Asp Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys Ser Arg Leu 
        35                  40                  45              


Asp Thr Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln Gln Ala Leu 
    50                  55                  60                  


Gln Thr Val Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp 
65                  70                  75                  80  


Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr 
                85                  90                  95      


Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys 
            100                 105                 110         


Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg 
        115                 120                 125             


Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys 
    130                 135                 140                 


Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val 
145                 150                 155                 160 


Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln 
                165                 170                 175     


Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu 
            180                 185                 190         


Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu 
        195                 200                 205             


Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp 
    210                 215                 220                 


Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg 
225                 230                 235                 240 


Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu 
                245                 250                 255     


Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu 
            260                 265                 270         


Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val 
        275                 280                 285             


Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr 
    290                 295                 300                 


Lys Lys Leu Asn Thr Gln 
305                 310 


<210>  58
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer N1

<400>  58
aaaaaagcgg ccgcgacaat tcgcgcgcga aggcg                                  35


<210>  59
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer N2

<400>  59
aaaaaagcgg ccgctcactg cccgctttcc agtcgg                                 36


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA protease cleavage site

<400>  60

Val Val Ala Pro Pro Ala Pro 
1               5           


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA protease cleavage site

<400>  61

Pro Ala Pro Ser Pro 
1               5   


<210>  62
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA protease cleavage site

<400>  62

Pro Pro Ser Pro 
1               


<210>  63
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA protease cleavage site

<400>  63

Pro Pro Ala Pro 
1               


<210>  64
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA protease cleavage site

<400>  64

Pro Pro Thr Pro 
1               


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA protease cleavage site

<400>  65

Pro Pro Gly Pro 
1               


<210>  66
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tetranectin-apolipoprotein A-I


<220>
<221>  MISC_FEATURE
<223>  X = A or G or S or T

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  66

Xaa Pro Ile Val Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe 
1               5                   10                  15      


Glu Glu Leu Lys Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu 
            20                  25                  30          


Leu Lys Glu Gln Gln Ala Leu Gln Thr Val Asp Glu Pro Pro Gln Ser 
        35                  40                  45              


Pro Trp Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu 
    50                  55                  60                  


Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu 
65                  70                  75                  80  


Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr 
                85                  90                  95      


Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu 
            100                 105                 110         


Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met 
        115                 120                 125             


Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp 
    130                 135                 140                 


Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys 
145                 150                 155                 160 


Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu 
                165                 170                 175     


His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp 
            180                 185                 190         


Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr 
        195                 200                 205             


Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys 
    210                 215                 220                 


Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu 
225                 230                 235                 240 


His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu 
                245                 250                 255     


Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu 
            260                 265                 270         


Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
        275                 280                 285 


<210>  67
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tetranectin-apolipoprotein A-I with N-terminal His-tag


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = any one of AP, GP, SP, PP, GSAP, GSGP, GSSP, GSPP, GGGS, 
       GGGGS, GGGSGGGS, GGGGSGGGGS, GGGSGGGSGGGS, GGGGSGGGGSGGGGS, 
       GGGSAP, GGGSGP, GGGSSP

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = any one of GGGSPP,  GGGGSAP, GGGGSGP, GGGGSSP, GGGGSPP,  
       GGGSGGGSAP, GGGSGGGSGP, GGGSGGGSSP, GGGSGGGSPP,  GGGSGGGSGGGSAP, 
       GGGSGGGSGGGSGP, GGGSGGGSGGGSSP, GGGSGGGSGGGSPP

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = any one of GGGGSAP, GGGGSGP, GGGGSSP, GGGGSPP, GGGGSGGGGSAP, 
       GGGGSGGGGSGP, GGGGSGGGGSSP, GGGGSGGGGSPP, GGGGSGGGGSGGGGSAP, 
       GGGGSGGGGSGGGGSGP, GGGGSGGGGSGGGGSSP, and GGGGSGGGGSGGGGSPP.

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  67

Met His His His His His His Xaa Ile Val Asn Ala Lys Lys Asp Val 
1               5                   10                  15      


Val Asn Thr Lys Met Phe Glu Glu Leu Lys Ser Arg Leu Asp Thr Leu 
            20                  25                  30          


Ala Gln Glu Val Ala Leu Leu Lys Glu Gln Gln Ala Leu Gln Thr Val 
        35                  40                  45              


Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
    50                  55                  60                  


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
65                  70                  75                  80  


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
                85                  90                  95      


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
            100                 105                 110         


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
        115                 120                 125             


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
    130                 135                 140                 


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
145                 150                 155                 160 


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
                165                 170                 175     


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
            180                 185                 190         


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
        195                 200                 205             


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
    210                 215                 220                 


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
225                 230                 235                 240 


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
                245                 250                 255     


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
            260                 265                 270         


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
        275                 280                 285             


Asn Thr Gln 
    290     


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  68

Gly Ser Ala Pro 
1               


<210>  69
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 2

<400>  69

Gly Ser Gly Pro 
1               


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3

<400>  70

Gly Ser Ser Pro 
1               


<210>  71
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 4

<400>  71

Gly Ser Pro Pro 
1               


<210>  72
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 5

<400>  72

Gly Gly Gly Ser 
1               


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 6

<400>  73

Gly Gly Gly Gly Ser 
1               5   


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 7

<400>  74

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 8

<400>  75

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 9

<400>  76

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 10

<400>  77

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 11

<400>  78

Gly Gly Gly Ser Ala Pro 
1               5       


<210>  79
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 12

<400>  79

Gly Gly Gly Ser Gly Pro 
1               5       


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 13

<400>  80

Gly Gly Gly Ser Ser Pro 
1               5       


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 14

<400>  81

Gly Gly Gly Ser Pro Pro 
1               5       


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 15

<400>  82

Gly Gly Gly Gly Ser Ala Pro 
1               5           


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 16

<400>  83

Gly Gly Gly Gly Ser Gly Pro 
1               5           


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 17

<400>  84

Gly Gly Gly Gly Ser Ser Pro 
1               5           


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 18

<400>  85

Gly Gly Gly Gly Ser Pro Pro 
1               5           


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 19

<400>  86

Gly Gly Gly Ser Gly Gly Gly Ser Ala Pro 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 20

<400>  87

Gly Gly Gly Ser Gly Gly Gly Ser Gly Pro 
1               5                   10  


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 21

<400>  88

Gly Gly Gly Ser Gly Gly Gly Ser Ser Pro 
1               5                   10  


<210>  89
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 22

<400>  89

Gly Gly Gly Ser Gly Gly Gly Ser Pro Pro 
1               5                   10  


<210>  90
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 23

<400>  90

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Pro 
1               5                   10                  


<210>  91
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 24

<400>  91

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Pro 
1               5                   10                  


<210>  92
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 25

<400>  92

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ser Pro 
1               5                   10                  


<210>  93
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 26

<400>  93

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Pro 
1               5                   10                  


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 27

<400>  94

Gly Gly Gly Gly Ser Ala Pro 
1               5           


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 28

<400>  95

Gly Gly Gly Gly Ser Gly Pro 
1               5           


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 29

<400>  96

Gly Gly Gly Gly Ser Ser Pro 
1               5           


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 30

<400>  97

Gly Gly Gly Gly Ser Pro Pro 
1               5           


<210>  98
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 31

<400>  98

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro 
1               5                   10          


<210>  99
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 32

<400>  99

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro 
1               5                   10          


<210>  100
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 33

<400>  100

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Pro 
1               5                   10          


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 34

<400>  101

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Pro 
1               5                   10          


<210>  102
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 35

<400>  102

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
1               5                   10                  15      


Pro 
    


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 36

<400>  103

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Pro 
    


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 37

<400>  104

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
1               5                   10                  15      


Pro 
    


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 38

<400>  105

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro 
1               5                   10                  15      


Pro 
    


