
SEQUENCE LISTING

<110> GILEAD BIOLOGICS, INC.
      MCCAULEY, Scott Alan
      KOVALENKO, Maria

<120> ANTIBODIES TO MATRIX METALLOPROTEINASE 9

<130> 246102008040

<140> PCT/US2011/049448   
<141> 2011-08-26  

<150> US 61/377,886       
<151> 2010-08-27  

<160> 29

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 470
<212> PRT
<213> Mus musculus

<220> 
<221> CHAIN          
<222> (1)...(470)
<223> AB0041 heavy chain

<220> 
<221> PEPTIDE         
<222> (1)...(19)
<223> signal peptide 

<220> 
<221> misc_feature        
<222> (135)...(470)
<223> IgG2b constant region

<400> 1
Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys
 1               5                  10                  15      
Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala
            20                  25                  30          
Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu
        35                  40                  45              
Leu Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Leu Gly Val Ile Trp Thr Gly Gly Thr Thr Asn Tyr Asn Ser
65                  70                  75                  80  
Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asp Ser Lys Ser Gln
                85                  90                  95      
Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr
            100                 105                 110         
Tyr Cys Ala Arg Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr
        115                 120                 125             
Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro
    130                 135                 140                 
Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly
145                 150                 155                 160 
Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr Trp Asn
                165                 170                 175     
Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu Leu Gln
            180                 185                 190         
Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser Ser Thr
        195                 200                 205             
Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro Ala Ser Ser
    210                 215                 220                 
Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile
225                 230                 235                 240 
Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn
                245                 250                 255     
Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp
            260                 265                 270         
Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp
        275                 280                 285             
Val Ser Glu Asp Asp Pro Asp Val Arg Ile Ser Trp Phe Val Asn Asn
    290                 295                 300                 
Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn
305                 310                 315                 320 
Ser Thr Ile Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp
                325                 330                 335     
Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro
            340                 345                 350         
Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg Ala
        355                 360                 365             
Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys
    370                 375                 380                 
Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile
385                 390                 395                 400 
Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp
                405                 410                 415     
Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys
            420                 425                 430         
Leu Asp Ile Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys
        435                 440                 445             
Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile
    450                 455                 460                 
Ser Arg Ser Pro Gly Lys
465                 470 


<210> 2
<211> 234
<212> PRT
<213> Mus musculus

<220> 
<221> CHAIN          
<222> (1)...(234)
<223> AB0041 light chain

<220> 
<221> PEPTIDE         
<222> (1)...(20)
<223> signal peptide

<220> 
<221> misc_feature         
<222> (128)...(234)
<223> kappa constant region

<400> 2
Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser
 1               5                  10                  15      
Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser
            20                  25                  30          
Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp
        35                  40                  45              
Val Arg Asn Thr Val Ala Trp Tyr Gln Gln Lys Thr Gly Gln Ser Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Ser Ser Tyr Arg Asn Thr Gly Val Pro Asp
65                  70                  75                  80  
Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser
                85                  90                  95      
Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Tyr
            100                 105                 110         
Ile Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
        115                 120                 125             
Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln
    130                 135                 140                 
Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr
145                 150                 155                 160 
Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln
                165                 170                 175     
Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr
            180                 185                 190         
Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg
        195                 200                 205             
His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro
    210                 215                 220                 
Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
225                 230                 


<210> 3
<211> 115
<212> PRT
<213> Mus musculus

<220> 
<221> CHAIN          
<222> (1)...(115)
<223> variable region of the IgG2b heavy chain of AB0041

<220> 
<221> misc_feature         
<222> (26)...(35)
<223> complementarity-determining region (CDR)

<220> 
<221> misc_feature         
<222> (50)...(65)
<223> complementarity-determining region (CDR)

<220> 
<221> misc_feature         
<222> (98)...(104)
<223> complementarity-determining region (CDR)

<400> 3
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Leu Ser Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Thr Gly Gly Thr Thr Asn Tyr Asn Ser Ala Leu Met
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asp Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 4
<211> 107
<212> PRT
<213> Mus musculus

<220> 
<221> CHAIN          
<222> (1)...(107)
<223> variable region of the kappa light chain of AB0041

<220> 
<221> misc_feature         
<222> (24)...(34)
<223> complementarity-determining region (CDR)

<220> 
<221> misc_feature         
<222> (50)...(56)
<223> complementarity-determining region (CDR)

<220> 
<221> misc_feature         
<222> (89)...(97)
<223> complementarity-determining region (CDR)

<400> 4
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Asn Thr
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Thr Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ser Ser Tyr Arg Asn Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Tyr Ile Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 5
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> VARIANT        
<222> (1)...(115)
<223> VH1 heavy chain variant

<400> 5
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Leu Ser Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Thr Gly Gly Thr Thr Asn Tyr Asn Ser Ala Leu Met
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Asp Ser Lys Ser Thr Val Tyr Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 6
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> VARIANT        
<222> (1)...(115)
<223> VH2 heavy chain variant

<400> 6
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Leu Ser Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Thr Gly Gly Thr Thr Asn Tyr Asn Ser Ala Leu Met
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Asp Ser Lys Asn Thr Val Tyr Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 7
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> VARIANT        
<222> (1)...(115)
<223> VH3 heavy chain variant

<400> 7
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Leu Ser Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Thr Gly Gly Thr Thr Asn Tyr Asn Ser Ala Leu Met
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Lys Asp Asp Ser Lys Asn Thr Val Tyr Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 8
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> VARIANT        
<222> (1)...(115)
<223> VH4 heavy chain variant

<400> 8
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Leu Ser Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Thr Gly Gly Thr Thr Asn Tyr Asn Ser Ala Leu Met
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Lys Asp Asp Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> VARIANT        
<222> (1)...(107)
<223> Vk1 light chain variant

<400> 9
Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Asn Thr
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Thr Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ser Ser Tyr Arg Asn Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala
65                  70                  75                  80  
Glu Asp Val Ala Val Tyr Phe Cys Gln Gln His Tyr Ile Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 10
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> VARIANT        
<222> (1)...(107)
<223> Vk2 light chain variant

<400> 10
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Asn Thr
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ser Ser Tyr Arg Asn Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala
65                  70                  75                  80  
Glu Asp Val Ala Val Tyr Phe Cys Gln Gln His Tyr Ile Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 11
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> VARIANT        
<222> (1)...(107)
<223> Vk3 light chain variant

<400> 11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Asn Thr
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ser Ser Tyr Arg Asn Thr Gly Val Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala
65                  70                  75                  80  
Glu Asp Val Ala Val Tyr Phe Cys Gln Gln His Tyr Ile Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 12
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> VARIANT        
<222> (1)...(107)
<223> Vk4 light chain variant

<400> 12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Asn Thr
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ser Ser Tyr Arg Asn Thr Gly Val Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala
65                  70                  75                  80  
Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature         
<222> (1)...(10)
<223> complementarity-determining region (CDR1) of heavy
      chain of anti-MMP9 antibody

<400> 13
Gly Phe Ser Leu Leu Ser Tyr Gly Val His
 1               5                  10  


<210> 14
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature         
<222> (1)...(16)
<223> complementarity-determining region (CDR2) of heavy
      chain of anti-MMP9 antibody

<400> 14
Val Ile Trp Thr Gly Gly Thr Thr Asn Tyr Asn Ser Ala Leu Met Ser
 1               5                  10                  15      


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature         
<222> (1)...(7)
<223> complementarity-determining region (CDR3) of heavy
      chain of anti-MMP9 antibody

<400> 15
Tyr Tyr Tyr Gly Met Asp Tyr
 1               5          


<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature         
<222> (1)...(11)
<223> complementarity-determining region (CDR1) of light
      chain of anti-MMP9 antibody

<400> 16
Lys Ala Ser Gln Asp Val Arg Asn Thr Val Ala
 1               5                  10      


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature         
<222> (1)...(7)
<223> complementarity-determining region (CDR2) of light
      chain of anti-MMP9 antibody

<400> 17
Ser Ser Ser Tyr Arg Asn Thr
 1               5          


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature         
<222> (1)...(9)
<223> complementarity-determining region (CDR3) of light
      chain of anti-MMP9 antibody

<400> 18
Gln Gln His Tyr Ile Thr Pro Tyr Thr
 1               5                  


<210> 19
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(345)
<223> nucleotide sequence encoding VH1 heavy chain amino
      acid sequence

<400> 19
caggtgcagc tgcaggaatc cggccctggc ctggtcaagc cctccgagac actgtccctg 60
acctgcaccg tgtccggctt ctccctgctg tcctacggcg tgcactgggt ccgacagcct 120
ccagggaagg gcctggaatg gctgggcgtg atctggaccg gcggcaccac caactacaac 180
tccgccctga tgtcccggct gaccatctcc aaggacgact ccaagtccac cgtgtacctg 240
aagatgaact ccctgaaaac cgaggacacc gccatctact actgcgcccg gtactactac 300
ggcatggact actggggcca gggcacctcc gtgaccgtgt cctca                 345

<210> 20
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(345)
<223> nucleotide sequence encoding VH2 heavy chain amino
      acid sequence

<400> 20
caggtgcagc tgcaggaatc cggccctggc ctggtcaagc cctccgagac actgtccctg 60
acctgcaccg tgtccggctt ctccctgctg tcctacggcg tgcactgggt ccgacagcct 120
ccaggcaaag gcctggaatg gctgggcgtg atctggaccg gcggcaccac caactacaac 180
tccgccctga tgtcccggct gaccatctcc aaggacgact ccaagaacac cgtgtacctg 240
aagatgaact ccctgaaaac cgaggacacc gccatctact actgcgcccg gtactactac 300
ggcatggact actggggcca gggcaccctg gtcaccgtgt cctca                 345

<210> 21
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(345)
<223> nucleotide sequence encoding VH3 heavy chain amino
      acid sequence

<400> 21
caggtgcagc tgcaggaatc cggccctggc ctggtcaagc cctccgagac actgtccctg 60
acctgcaccg tgtccggctt ctccctgctg tcctacggcg tgcactgggt ccgacagcct 120
ccaggcaaag gcctggaatg gctgggcgtg atctggaccg gcggcaccac caactacaac 180
tccgccctga tgtcccggtt caccatctcc aaggacgact ccaagaacac cgtgtacctg 240
aagatgaact ccctgaaaac cgaggacacc gccatctact actgcgcccg gtactactac 300
ggcatggact actggggcca gggcaccctg gtcaccgtgt cctca                 345

<210> 22
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(345)
<223> nucleotide sequence encoding VH4 heavy chain amino
      acid sequence

<400> 22
caggtgcagc tgcaggaatc cggccctggc ctggtcaagc cctccgagac actgtccctg 60
acctgcaccg tgtccggctt ctccctgctg tcctacggcg tgcactgggt ccgacagcct 120
ccaggcaaag gcctggaatg gctgggcgtg atctggaccg gcggcaccac caactacaac 180
tccgccctga tgtcccggtt caccatctcc aaggacgact ccaagaacac cctgtacctg 240
aagatgaact ccctgaaaac cgaggacacc gccatctact actgcgcccg gtactactac 300
ggcatggact actggggcca gggcaccctg gtcaccgtgt cctca                 345

<210> 23
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(321)
<223> nucleotide sequence encoding Vk1 light chain amino
      acid sequence

<400> 23
gacatcgtga tgacccagtc ccccagcttc ctgtccgcct ccgtgggcga cagagtgacc 60
atcacatgca aggcctctca ggacgtgcgg aacaccgtgg cctggtatca gcagaaaacc 120
ggcaaggccc ccaagctgct gatctactcc tcctcctacc ggaacaccgg cgtgcccgac 180
cggtttaccg gctctggctc cggcaccgac tttaccctga ccatcagctc cctgcaggcc 240
gaggacgtgg ccgtgtactt ctgccagcag cactacatca ccccctacac cttcggcgga 300
ggcaccaagg tggaaataaa a                                           321

<210> 24
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(321)
<223> nucleotide sequence encoding Vk2 light chain amino
      acid sequence

<400> 24
gacatcgtga tgacccagtc cccctccagc ctgtccgcct ctgtgggcga cagagtgacc 60
atcacatgca aggcctctca ggacgtgcgg aacaccgtgg cctggtatca gcagaagccc 120
ggcaaggccc ccaagctgct gatctactcc tcctcctacc ggaacaccgg cgtgcccgac 180
cggtttaccg gctctggctc cggcaccgac tttaccctga ccatcagctc cctgcaggcc 240
gaggacgtgg ccgtgtactt ctgccagcag cactacatca ccccctacac cttcggcgga 300
ggcaccaagg tggaaataaa a                                           321

<210> 25
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(321)
<223> nucleotide sequence encoding Vk3 light chain amino
      acid sequence

<400> 25
gacatccaga tgacccagtc cccctccagc ctgtccgcct ctgtgggcga cagagtgacc 60
atcacatgca aggcctccca ggacgtgcgg aacaccgtgg cctggtatca gcagaagccc 120
ggcaaggccc ccaagctgct gatctactcc tcctcctacc ggaacaccgg cgtgcccgac 180
cggttctctg gctctggaag cggcaccgac tttaccctga ccatcagctc cctgcaggcc 240
gaggacgtgg ccgtgtactt ctgccagcag cactacatca ccccctacac cttcggcgga 300
ggcaccaagg tggaaataaa a                                           321

<210> 26
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic construct

<220> 
<221> misc_feature   
<222> (1)...(321)
<223> nucleotide sequence encoding Vk4 light chain amino
      acid sequence

<400> 26
gacatccaga tgacccagtc cccctccagc ctgtccgcct ctgtgggcga cagagtgacc 60
atcacatgca aggcctctca ggacgtgcgg aacaccgtgg cctggtatca gcagaagccc 120
ggcaaggccc ccaagctgct gatctactcc tcctcctacc ggaacaccgg cgtgcccgac 180
cggttctctg gctctggaag cggcaccgac tttaccctga ccatcagctc cctgcaggcc 240
gaggacgtgg ccgtgtacta ctgccagcag cactacatca ccccctacac cttcggcgga 300
ggcaccaagg tggaaataaa a                                           321

<210> 27
<211> 707
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature         
<222> (1)...(707)
<223> matrix metalloproteinase 9 (MMP9)

<220> 
<221> PEPTIDE        
<222> (1)...(19)
<223> signal peptide

<220> 
<221> DOMAIN         
<222> (38)...(98)
<223> peptidoglycan binding domain

<220> 
<221> SITE           
<222> (98)...(99)
<223> propeptide cleavage site

<220> 
<221> DOMAIN         
<222> (112)...(445)
<223> Zn dependent metalloproteinase domain

<220> 
<221> DOMAIN         
<222> (223)...(271)
<223> fibronectin type II domain (gelatin binding
      domain)

<220> 
<221> DOMAIN         
<222> (281)...(329)
<223> fibronectin type II domain (gelatin binding
      domain)

<220> 
<221> DOMAIN         
<222> (340)...(388)
<223> fibronectin type II domain (gelatin binding
      domain)

<220> 
<221> misc_feature         
<222> (400)...(411)
<223> Zn binding region

<220> 
<221> DOMAIN         
<222> (521)...(565)
<223> hemopexin-like domain

<220> 
<221> DOMAIN         
<222> (567)...(608)
<223> hemopexin-like domain

<220> 
<221> DOMAIN         
<222> (613)...(659)
<223> hemopexin-like domain

<220> 
<221> DOMAIN         
<222> (661)...(704)
<223> hemopexin-like domain


<400> 27
Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys
 1               5                  10                  15      
Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro
            20                  25                  30          
Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr
        35                  40                  45              
Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser
    50                  55                  60                  
Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu
65                  70                  75                  80  
Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr
                85                  90                  95      
Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly
            100                 105                 110         
Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr
        115                 120                 125             
Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala
    130                 135                 140                 
Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr
145                 150                 155                 160 
Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly
                165                 170                 175     
Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe
            180                 185                 190         
Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu
        195                 200                 205             
Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn
    210                 215                 220                 
Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser
225                 230                 235                 240 
Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys
                245                 250                 255     
Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro
            260                 265                 270         
Ser Glu Arg Leu Tyr Thr Arg Asp Gly Asn Ala Asp Gly Lys Pro Cys
        275                 280                 285             
Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr
    290                 295                 300                 
Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr
305                 310                 315                 320 
Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr
                325                 330                 335     
Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr
            340                 345                 350         
Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp
        355                 360                 365             
Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys
    370                 375                 380                 
Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala
385                 390                 395                 400 
His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu
                405                 410                 415     
Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His
            420                 425                 430         
Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu
        435                 440                 445             
Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro
    450                 455                 460                 
Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg
465                 470                 475                 480 
Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro
                485                 490                 495     
Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val
            500                 505                 510         
Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly
        515                 520                 525             
Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu
    530                 535                 540                 
Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp
545                 550                 555                 560 
Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Pro Leu Ser
                565                 570                 575     
Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly
            580                 585                 590         
Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala
        595                 600                 605             
Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met
    610                 615                 620                 
Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln
625                 630                 635                 640 
Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly
                645                 650                 655     
Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr
            660                 665                 670         
Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu
        675                 680                 685             
Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys
    690                 695                 700                 
Pro Glu Asp
705         


<210> 28
<211> 687
<212> PRT
<213> Homo sapiens

<220> 
<221> misc_feature         
<222> (1)...(687)
<223> mature full-length matrix metalloproteinase 9
      (MMP9)

<400> 28
Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro Gly Asp Leu Arg
 1               5                  10                  15      
Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr Leu Tyr Arg Tyr
            20                  25                  30          
Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser Lys Ser Leu Gly
        35                  40                  45              
Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu Pro Glu Thr Gly
    50                  55                  60                  
Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr Pro Arg Cys Gly
65                  70                  75                  80  
Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly Asp Leu Lys Trp
                85                  90                  95      
His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr Ser Glu Asp Leu
            100                 105                 110         
Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala Phe Ala Leu Trp
        115                 120                 125             
Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr Ser Arg Asp Ala
    130                 135                 140                 
Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly Asp Gly Tyr Pro
145                 150                 155                 160 
Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe Pro Pro Gly Pro
                165                 170                 175     
Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu Leu Trp Ser Leu
            180                 185                 190         
Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn Ala Asp Gly Ala
        195                 200                 205             
Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser Tyr Ser Ala Cys
    210                 215                 220                 
Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys Ser Thr Thr Ala
225                 230                 235                 240 
Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro Ser Glu Arg Leu
                245                 250                 255     
Tyr Thr Arg Asp Gly Asn Ala Asp Gly Lys Pro Cys Gln Phe Pro Phe
            260                 265                 270         
Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser
        275                 280                 285             
Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr Asp Arg Asp Lys
    290                 295                 300                 
Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr Val Met Gly Gly
305                 310                 315                 320 
Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr Phe Leu Gly Lys
                325                 330                 335     
Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp Gly Arg Leu Trp
            340                 345                 350         
Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys Trp Gly Phe Cys
        355                 360                 365             
Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala His Glu Phe Gly
    370                 375                 380                 
His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu Ala Leu Met Tyr
385                 390                 395                 400 
Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His Lys Asp Asp Val
                405                 410                 415     
Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu Pro Glu Pro Arg
            420                 425                 430         
Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro Pro Thr Val Cys
        435                 440                 445             
Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg Pro Thr Ala Gly
    450                 455                 460                 
Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro Pro Thr Ala Gly
465                 470                 475                 480 
Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val Asp Asp Ala Cys
                485                 490                 495     
Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly Asn Gln Leu Tyr
            500                 505                 510         
Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu Gly Arg Gly Ser
        515                 520                 525             
Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp Pro Ala Leu Pro
    530                 535                 540                 
Arg Lys Leu Asp Ser Val Phe Glu Glu Pro Leu Ser Lys Lys Leu Phe
545                 550                 555                 560 
Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly Ala Ser Val Leu
                565                 570                 575     
Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala Asp Val Ala Gln
            580                 585                 590         
Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met Leu Leu Phe Ser
        595                 600                 605             
Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln Met Val Asp Pro
    610                 615                 620                 
Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly Val Pro Leu Asp
625                 630                 635                 640 
Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr Phe Cys Gln Asp
                645                 650                 655     
Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu Asn Gln Val Asp
            660                 665                 670         
Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys Pro Glu Asp
        675                 680                 685         


<210> 29
<211> 20
<212> PRT
<213> Homo sapiens

<220> 
<221> PEPTIDE        
<222> (1)...(20)
<223> matrix metalloproteinase 9 (MMP9) signal peptide

<400> 29
Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys
 1               5                  10                  15      
Cys Phe Ala Ala
            20  

