                               SEQUENCE LISTING	

<110> THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
 
<120> OPTIMIZED MIRNA CONSTRUCTS

<130> 19240-907WO1

<140>
<141>

<150> 61/376,922
<151> 2010-08-25

<160> 108   

<170> PatentIn version 3.5

<210> 1
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
uaugugagca ugaaacuaug cac                                               23


<210> 2
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
uugcauaguc acaaaaguga uc                                                22


<210> 3
<211> 102
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
aaggctcaca gctgccagtg tcatttttgt gatctgcagc tagtattctc actccagttg       60

catagtcaca aaagtgatca ttggcaggtg tggctatagt ga                         102


<210> 4
<211> 97
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
gggggcucac agcugccagu gucauuuuug ugaucugcag cuaguauucu cacuccaguu       60

gcauagucac aaaagugauc auuggcaggu guggcuu                                97


<210> 5
<211> 104
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
aaggctcaca gctgccagtt tgtgagcatg aaacctgcac ctagtattct cactccaggt       60

gcatagtttc atgctcacat aattggcagg tgtggctata gtga                       104


<210> 6
<211> 99
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
gggggcucac agcugccagu uugugagcau gaaaccugca ccuaguauuc ucacuccagg       60

ugcauaguuu caugcucaca uaauuggcag guguggcuu                              99


<210> 7
<211> 106
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
aaggctcaca gctgccagtt atgtgagcat gaaactatgc acctagtatt ctcactccag       60

gtgcatagtt tcatgctcac ataattggca ggtgtggcta tagtga                     106


<210> 8
<211> 101
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 8
gggggcucac agcugccagu uaugugagca ugaaacuaug caccuaguau ucucacucca       60

ggtgcauagu uucaugcuca cauaauuggc agguguggcu u                          101


<210> 9
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
auuaaugggu uuuguguacu gua                                               23


<210> 10
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
uacaguacug ugauaacuga a                                                 21


<210> 11
<211> 75
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
ugcccuggcu caguuaucac agugcugaug cugucuauuc uaaagguaca guacugugau       60

aacugaagga uggca                                                        75


<210> 12
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 12
ugcccuggat taatgggttt tgtgtactgt agucuauucu aaaggtacag tacacaaaac       60

ccattaatgg auggca                                                       76


<210> 13
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
aaggtgccct ggattaatgg gttttgtgta ctgtagtcta ttctaaaggt acagtacaca       60

aaacccatta atggatggca tatagtga                                          88


<210> 14
<211> 83
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
gggggugccc uggauuaaug gguuuugugu acuguagucu auucuaaagg uacaguacac       60

aaaacccauu aauggauggc auu                                               83


<210> 15
<211> 90
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
cucacagcug ccagugucau uuuugugauc ugcagcuagu auucucacuc caguugcaua       60

gucacaaaag ugaucauugg cagguguggc                                        90


<210> 16
<211> 94
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 16
cucacagcug ccaguttcct ttcctgatca ctatgcatcu aguauucuca cuccagatgc       60

atagtgatca ggaaaggaaa uuggcaggug uggc                                   94


<210> 17
<211> 106
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
aaggctcaca gctgccagtt tcctttcctg atcactatgc atctagtatt ctcactccag       60

atgcatagtg atcaggaaag gaaattggca ggtgtggcta tagtga                     106


<210> 18
<211> 101
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
gggggcucac agcugccagu uuccuuuccu gaucacuaug caucuaguau ucucacucca       60

gaugcauagu gaucaggaaa ggaaauuggc agguguggcu u                          101


<210> 19
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
uuccuuuccu gaucacuaug cau                                               23


<210> 20
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
uugcauaguc acaaaaguga uc                                                22


<210> 21
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
cccuguucau uguaagcacu uuu                                               23


<210> 22
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
aaaagugcuu acagugcagg uag                                               23


<210> 23
<211> 81
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
ccuuggccau guaaaagugc uuacagugca gguagcuuuu ugagaucuac ugcaauguaa       60

gcacuucuua cauuaccaug g                                                 81


<210> 24
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 24
ccuuggccau guaaaagtgc ttacaatgaa cagggcuuuu ugagauccct gttcattgta       60

agcactttta cauuaccaug g                                                 81


<210> 25
<211> 93
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
aaggccttgg ccatgtaaaa gtgcttacaa tgaacagggc tttttgagat ccctgttcat       60

tgtaagcact tttacattac catggtatag tga                                    93


<210> 26
<211> 88
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
gggggccuug gccauguaaa agugcuuaca augaacaggg cuuuuugaga ucccuguuca       60

uuguaagcac uuuuacauua ccaugguu                                          88


<210> 27
<211> 147
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(10)
<223> This region may encompass 0-3, 0-5, 0-10, or 0, 1, 2, 3, 4, 5, 
      6, 7, 8, 9, or 10 nucleotides

<220>
<221> modified_base
<222> (11)..(45)
<223> a, c, t, g, unknown or other and this region may encompass 
      20-35, 25-35, 20-33, 28-35, 28-33, or 20, 21, 22, 23, 24, 25, 
      26, 27, 28, 29, 30, 31, 32, 33, 34, or 35 nucleotides

<220>
<221> modified_base
<222> (46)..(110)
<223> a, c, t, g, unknown or other; this region may encompass 20, 21,
      22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37,
      38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53,
      54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, or 65 nucleotides

<220>
<221> modified_base
<222> (111)..(145)
<223> a, c, t, g, unknown or other and this region may encompass 
      20-35, 25-35, 20-33, 28-35, 28-33, or 20, 21, 22, 23, 24, 25, 
      26, 27, 28, 29, 30, 31, 32, 33, 34, or 35 nucleotides

<220> 
<223> see specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 27
gggggggggg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnuu                                          147



<210> 28
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
uaugugagca ugaaacuaug cac                                               23


<210> 29
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
uugcauaguc acaaaaguga uc                                                22


<210> 30
<211> 102
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
aaggctcaca gctgccagtg tcatttttgt gatctgcagc tagtattctc actccagttg       60

catagtcaca aaagtgatca ttggcaggtg tggctatagt ga                         102


<210> 31
<211> 97
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
gggggcucac agcugccagu gucauuuuug ugaucugcag cuaguauucu cacuccaguu       60

gcauagucac aaaagugauc auuggcaggu guggcuu                                97


<210> 32
<211> 104
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
aaggctcaca gctgccagtt tgtgagcatg aaacctgcac ctagtattct cactccaggt       60

gcatagtttc atgctcacat aattggcagg tgtggctata gtga                       104


<210> 33
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 33
gggggcucac agcugccagu uugugagcau gaaaccugca ccuaguauuc ucacuccagg       60

ugcauaguuu catgcucaca uaauuggcag guguggcuu                              99


<210> 34
<211> 101
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 34
gggggcucac agcugccagu uatgugagca ugaaacuaug caccuaguau ucucacucca       60

ggugcauagu uucaugcuca cauaauuggc agguguggcu u                          101


<210> 35
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
acaguguauc ucgaagucuu cca                                               23


<210> 36
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
uggaagacua gugauuuugu ugu                                               23


<210> 37
<211> 122
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
aaggctggat acagagtgga ccggctggcc ccatctggaa gactagtgat tttgttgttg       60

tcttactgcg ctcaacaaca aatcccagtc tacctaatgg tgccagccat cgcatatagt      120

ga                                                                     122


<210> 38
<211> 117
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 38
gggggcugga uacagagugg accggcuggc cccaucugga agacuaguga uuuuguuguu       60

gucuuacugc gcucaacaac aaaucccagu cuaccuaaug gugccagcca ucgcauu         117


<210> 39
<211> 122
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
aaggctggat acagagtgga ccggctggcc ccatctggaa gacttcgaga tacactgttg       60

tcttactgcg ctcaacagtt atctatagtc tacctaatgg tgccagccat cgcatatagt      120

ga                                                                     122


<210> 40
<211> 117
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 40
gggggcugga uacagagugg accggcuggc cccaucugga agacuucgag auacacuguu       60

gucuuacugc gcucaacagu uatcuauagu cuaccuaaug gugccagcca ucgcauu         117


<210> 41
<211> 124
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
aaggctggat acagagtgga ccggctggcc ccatctggaa gacttcgaga tacactgttg       60

tcttactgcg ctcaacagtg tatctcgaag tcttccaaat ggtgccagcc atcgcatata      120

gtga                                                                   124


<210> 42
<211> 119
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 42
gggggcugga uacagagugg accggcuggc cccaucugga agacuucgag auacacuguu       60

gucuuacugc gcucaacagu gtaucucgaa gucuuccaaa uggugccagc caucgcauu       119


<210> 43
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
ugacguauug ugaaauuugu uaa                                               23


<210> 44
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
aaacaaacau ggugcacuuc uu                                                22


<210> 45
<211> 94
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 45
aaggtggtac ctgaaaagaa gttgcccaug ttattttcgc tttatatgtg acgaaacaaa       60

catggtgcac ttctttttcg gtatcatata gtga                                   94


<210> 46
<211> 89
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
ggggguggua ccugaaaaga aguugcccau guuauuuucg cuuuauaugu gacgaaacaa       60

acauggugca cuucuuuuuc gguaucauu                                         89


<210> 47
<211> 94
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
aaggtggtac ctgaatgacg tagtttgaaa ttacttacgc tttatatgtg acgtaacaaa       60

tttcacaata cgtcatttcg gtatcatata gtga                                   94


<210> 48
<211> 89
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
ggggguggua ccugaaugac guaguuugaa auuacuuacg cuuuauaugu gacguaacaa       60

auuucacaau acgucauuuc gguaucauu                                         89


<210> 49
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
aaggtggtac ctgaatgacg tattgtgaaa tttgttaacg ctttatatgt gacgttaaca       60

aatttcacaa tacgtcattt cggtatcata tagtga                                 96


<210> 50
<211> 91
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
ggggguggua ccugaaugac guauugugaa auuuguuaac gcuuuauaug ugacguuaac       60

aaauuucaca auacgucauu ucgguaucau u                                      91


<210> 51
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
uaugugagca ugaaacuaug cac                                               23


<210> 52
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
uugcauaguc acaaaaguga uc                                                22


<210> 53
<211> 102
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 53
aaggctcaca gctgccagtg tcatttttgt gatctgcagc tagtattctc actccagttg       60

catagtcaca aaagtgatca ttggcaggtg tggctatagt ga                         102


<210> 54
<211> 97
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
gggggcucac agcugccagu gucauuuuug ugaucugcag cuaguauucu cacuccaguu       60

gcauagucac aaaagugauc auuggcaggu guggcuu                                97


<210> 55
<211> 104
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 55
aaggctcaca gctgccagtt tgtgagcatg aaacctgcac ctagtattct cactccaggt       60

gcatagtttc atgctcacat aattggcagg tgtggctata gtga                       104


<210> 56
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 56
gggggcucac agcugccagu uugugagcau gaaaccugca ccuaguauuc ucacuccagg       60

ugcauaguuu catgcucaca uaauuggcag guguggcuu                              99


<210> 57
<211> 106
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 57
aaggctcaca gctgccagtt atgtgagcat gaaactatgc acctagtatt ctcactccag       60

gtgcatagtt tcatgctcac ataattggca ggtgtggcta tagtga                     106


<210> 58
<211> 101
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 58
gggggcucac agcugccagu uatgugagca ugaaacuaug caccuaguau ucucacucca       60

ggugcauagu uucaugcuca cauaauuggc agguguggcu u                          101


<210> 59
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 59
acaguguauc ucgaagucuu cca                                               23


<210> 60
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
uggaagacua gugauuuugu ugu                                               23


<210> 61
<211> 122
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 61
aaggctggat acagagtgga ccggctggcc ccatctggaa gactagtgat tttgttgttg       60

tcttactgcg ctcaacaaca aatcccagtc tacctaatgg tgccagccat cgcatatagt      120

ga                                                                     122


<210> 62
<211> 117
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 62
gggggcugga uacagagugg accggcuggc cccaucugga agacuaguga uuuuguuguu       60

gucuuacugc gcucaacaac aaaucccagu cuaccuaaug gugccagcca ucgcauu         117


<210> 63
<211> 122
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 63
aaggctggat acagagtgga ccggctggcc ccatctggaa gacttcgaga tacactgttg       60

tcttactgcg ctcaacagtt atctatagtc tacctaatgg tgccagccat cgcatatagt      120

ga                                                                     122


<210> 64
<211> 117
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 64
gggggcugga uacagagugg accggcuggc cccaucugga agacuucgag auacacuguu       60

gucuuacugc gcucaacagu uatcuauagu cuaccuaaug gugccagcca ucgcauu         117


<210> 65
<211> 124
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 65
aaggctggat acagagtgga ccggctggcc ccatctggaa gacttcgaga tacactgttg       60

tcttactgcg ctcaacagtg tatctcgaag tcttccaaat ggtgccagcc atcgcatata      120

gtga                                                                   124


<210> 66
<211> 119
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 66
gggggcugga uacagagugg accggcuggc cccaucugga agacuucgag auacacuguu       60

gucuuacugc gcucaacagu gtaucucgaa gucuuccaaa uggugccagc caucgcauu       119


<210> 67
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 67
ugacguauug ugaaauuugu uaa                                               23


<210> 68
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 68
aaacaaacau ggugcacuuc uu                                                22


<210> 69
<211> 94
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 69
aaggtggtac ctgaaaagaa gttgcccaug ttattttcgc tttatatgtg acgaaacaaa       60

catggtgcac ttctttttcg gtatcatata gtga                                   94


<210> 70
<211> 89
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 70
ggggguggua ccugaaaaga aguugcccau guuauuuucg cuuuauaugu gacgaaacaa       60

acauggugca cuucuuuuuc gguaucauu                                         89


<210> 71
<211> 94
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
aaggtggtac ctgaatgacg tagtttgaaa ttacttacgc tttatatgtg acgtaacaaa       60

tttcacaata cgtcatttcg gtatcatata gtga                                   94


<210> 72
<211> 91
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
ggggguggua ccugaaugac guauugugaa auuuguuaac gcuuuauaug ugacguuaac       60

aaauuucaca auacgucauu ucgguaucau u                                      91


<210> 73
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
auuaaugggu uuuguguacu gua                                               23


<210> 74
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
uacaguacug ugauaacuga a                                                 21


<210> 75
<211> 75
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
ugcccuggcu caguuaucac agugcugaug cugucuauuc uaaagguaca guacugugau       60

aacugaagga uggca                                                        75


<210> 76
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 76
ugcccuggat taatgggttt tgtgtactgt agucuauucu aaaggtacag tacacaaaac       60

ccattaatgg auggca                                                       76


<210> 77
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
aaggtgccct ggattaatgg gttttgtgta ctgtagtcta ttctaaaggt acagtacaca       60

aaacccatta atggatggca tatagtga                                          88


<210> 78
<211> 83
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
gggggugccc uggauuaaug gguuuugugu acuguagucu auucuaaagg uacaguacac       60

aaaacccauu aauggauggc auu                                               83


<210> 79
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
uuccuuuccu gaucacuaug cau                                               23


<210> 80
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
uugcauaguc acaaaaguga uc                                                22


<210> 81
<211> 90
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
cucacagcug ccagugucau uuuugugauc ugcagcuagu auucucacuc caguugcaua       60

gucacaaaag ugaucauugg cagguguggc                                        90


<210> 82
<211> 94
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 82
cucacagcug ccaguttcct ttcctgatca ctatgcatcu aguauucuca cuccagatgc       60

atagtgatca ggaaaggaaa uuggcaggug uggc                                   94


<210> 83
<211> 106
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 83
aaggctcaca gctgccagtt tcctttcctg atcactatgc atctagtatt ctcactccag       60

atgcatagtg atcaggaaag gaaattggca ggtgtggcta tagtga                     106


<210> 84
<211> 101
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 84
gggggcucac agcugccagu uuccuuuccu gaucacuaug caucuaguau ucucacucca       60

gaugcauagu gaucaggaaa ggaaauuggc agguguggcu u                          101


<210> 85
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
cccuguucau uguaagcacu uuu                                               23


<210> 86
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
aaaagugcuu acagugcagg uag                                               23


<210> 87
<211> 81
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
ccuuggccau guaaaagugc uuacagugca gguagcuuuu ugagaucuac ugcaauguaa       60

gcacuucuua cauuaccaug g                                                 81


<210> 88
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 88
ccuuggccau guaaaagtgc ttacaatgaa cagggcuuuu ugagauccct gttcattgta       60

agcactttta cauuaccaug g                                                 81


<210> 89
<211> 93
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 89
aaggccttgg ccatgtaaaa gtgcttacaa tgaacagggc tttttgagat ccctgttcat       60

tgtaagcact tttacattac catggtatag tga                                    93


<210> 90
<211> 88
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 90
gggggccuug gccauguaaa agugcuuaca augaacaggg cuuuuugaga ucccuguuca       60

uuguaagcac uuuuacauua ccaugguu                                          88


<210> 91
<211> 90
<212> RNA
<213> Homo sapiens

<400> 91
cucacagcug ccagugucau uuuugugauc ugcagcuagu auucucacuc caguugcaua       60

gucacaaaag ugaucauugg cagguguggc                                        90


<210> 92
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 92
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 93
<211> 26
<212> RNA
<213> Mus sp.

<400> 93
aauuauguga gguagagacu augcac                                            26


<210> 94
<211> 87
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 94
agcgguggcc agugucauuu uugugauguu gcagcuagua auaugagccc aguugcauag       60

ucacaaaagu gaucauugga aacugug                                           87


<210> 95
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 95
taatacgact cactata                                                      17


<210> 96
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(30)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (38)..(65)
<223> a, c, t, g, unknown or other

<400> 96
aannnnnnnn nnnnnnnnnn nnnnnnnnnn tcatattnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnntatag tga                                                          73


<210> 97
<211> 82
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (18)..(45)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (53)..(80)
<223> a, c, t, g, unknown or other

<400> 97
taatacgact cactatannn nnnnnnnnnn nnnnnnnnnn nnnnnaatat gannnnnnnn       60

nnnnnnnnnn nnnnnnnnnn tt                                                82


<210> 98
<211> 74
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (4)..(34)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (42)..(72)
<223> a, c, t, g, unknown or other

<400> 98
gggnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnaauaug annnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnuu                                                         74


<210> 99
<211> 74
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (4)..(34)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (42)..(72)
<223> a, c, t, g, unknown or other

<400> 99
gggnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnaauaug annnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnuu                                                         74


<210> 100
<211> 87
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
agcgguggcc agugucauuu uugugauguu gcagcuagua auaugagccc aguugcauag       60

ucacaaaagu gaucauugga aacugug                                           87


<210> 101
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (4)..(34)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (42)..(47)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (69)..(71)
<223> a, c, t, g, unknown or other

<400> 101
gggnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnaauaug annnnnnuug cauagucaca       60

aagugaucnn nuu                                                          73


<210> 102
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (4)..(34)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (42)..(47)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (71)..(73)
<223> a, c, t, g, unknown or other

<400> 102
gggnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnaauaug annnnnngug cauaguuuca       60

ugcucacaua nnnuu                                                        75


<210> 103
<211> 74
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (4)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (28)..(33)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (41)..(46)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (70)..(72)
<223> a, c, t, g, unknown or other

<400> 103
gggnnuugug agcaugaaac guugcacnnn nnnaauauga nnnnnngugc auaguuucau       60

gcucacaaan nnuu                                                         74


<210> 104
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (4)..(5)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (29)..(34)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (42)..(47)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (71)..(73)
<223> a, c, t, g, unknown or other

<400> 104
gggnnuaugu gagcaugaaa cuaugcacnn nnnnaauaug annnnnngug cauaguuuca       60

ugcucacaua nnnuu                                                        75


<210> 105
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
aaggtggtac ctgaatgacg tattgtgaaa tttgttaacg ctttatatgt gacgttaaca       60

aatttcacaa tacgtcattt cggtatcata tagtga                                 96


<210> 106
<211> 89
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
ggggguggua ccugaaugac guaguuugaa auuacuuacg cuuuauaugu gacguaacaa       60

auuucacaau acgucauuuc gguaucauu                                         89


<210> 107
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 107
aaggtggtac ctgaatgacg tattgtgaaa tttgttaacg ctttatatgt gacgttaaca       60

aatttcacaa tacgtcattt cggtatcata tagtga                                 96


<210> 108
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(5)
<223> a, c, t, g, unknown or other 

<400> 108
aannntatag tga                                                          13



