                         SEQUENCE LISTING

<110>  Coste, Bertrand
       Patapoutian, Ardem
 
<120>  Mechanically-Activated Cation Channels

<130>  87396-817888

<150>  61/376,182
<151>  2010-08-23

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  7644
<212>  DNA
<213>  Mus musculus

<400>  1
atggagccgc acgtgctggg cgccgggctc tactggctgt tgctgccctg cacgctcctg       60

gcggcctccc tgttacgctt caatgctctc tcgctggtct atttgctgtt tctactgctg      120

ctgccctggc ttccaggccc ctcaagacac agcataccag gtcacacagg tcgcctgctc      180

cgtgcactac tctgcctcag cctcctcttc ctggtggccc accttgcctt tcagatatgc      240

ctacacaccg tgcctcacct ggaccagttt ctgggacaaa acggtagcct ttgggtgaag      300

gtgtctcaac acataggggt tacgaggctg gacctgaagg acatctttaa caccaccagg      360

ctggtagcac ctgacctggg agtgctgctg gcgtcctccc tttgccttgg cctctgtgga      420

cgcctcacga ggaaagccgg gcagagtcgg cgcacccagg agctgcagga tgatgacgat      480

gacgatgatg acgacgatga agacatagat gctgccccag ccgtggggct gaagggagcc      540

cctgccctgg caaccaaacg caggctgtgg ctggcctccc gcttccgggt cacggcccac      600

tggctgctga tgacctctgg acggacgctg gtcattgtgt tgctggccct ggcaggcata      660

gcccaccctt cggccttctc cagcatctac ctggtggtgt tcctggccat ctgcacctgg      720

tggtcctgtc actttcctct cagccccctg ggctttaaca ccctctgtgt catggtgagc      780

tgttttggtg ccggccatct catttgccta tactgctatc agacaccatt tatccaggac      840

atgttacccc ctgggaacat ctgggccagg ctatttggtc tcaagaactt cgtagacctc      900

cctaactact ccagccccaa cgccctggta ctcaacacta agcacgcctg gcccatctat      960

gtgagtcccg gaatcctgct gctgctatat tacacagcca cctctctcct gaagctccac     1020

aagagctgtc cctcagagct gaggaaggag acacccaggg aggatgagga gcatgagctg     1080

gaactggacc acctggagcc agagccccag gctagggacg ccacccaggg tgagatgccc     1140

atgaccacgg aacctgacct tgacaactgc accgtgcatg tactaaccag ccagagccct     1200

gtccgccagc gtccagttcg ccccaggctg gctgagctga aagagatgtc accgctacat     1260

ggcctgggcc acctcatcat ggaccagagc tatgtgtgtg ccctgattgc catgatggtg     1320

tggagcatca tgtaccacag ttggctgacc ttcgtcctgc tgctctgggc ctgcctcatc     1380

tggacggtgc gtagccgtca ccagctggct atgctctgct cgccctgcat cctgctgtat     1440

gggctgacgc tctgctgcct gaggtatgtg tgggccatgg aacttcctga gctgcccacc     1500

accctgggcc ctgtcagcct gcaccagttg ggactggaac acacacgcta cccttgcctg     1560

gacctcggtg ccatgctcct ctatctgctc acattctggc tccttctgcg tcagttcgtg     1620

aaggagaagc tgctgaagaa gcaaaaggtg cctgcggcgc tgctggaggt cacggtggcc     1680

gacactgagc ccacacagac ccagacgctg ctgcggagcc tgggggagct ggtcaccggc     1740

atctacgtca aatactggat ctatgtgtgc gccggcatgt tcattgtggt cagcttcgcc     1800

ggccgcctgg tggtctacaa aatcgtctac atgttcctct tcctgctgtg cctcaccttg     1860

ttccaggtct actacaccct gtggaggaag ctgctacgtg tcttctggtg gctcgtggtg     1920

gcctatacaa tgctcgtgct catcgctgtg tacaccttcc agttccagga cttccccacc     1980

tattggcgca acctcacggg cttcacagac gagcagttgg gcgacctggg cctggagcag     2040

ttcagtgtgt cggagctctt ttccagtatc ctcatccctg gcttcttcct gctggcctgc     2100

atcctgcagc tgcactactt ccacagaccg ttcatgcagc tcactgacct ggagcacgtg     2160

ccgccaccag gcacccgcca ccctcgatgg gctcacaggc aggatgcagt gagcgaggcc     2220

cctctgcttg agcatcagga ggaagaggaa gtcttcaggg aagatgggca gagcatggat     2280

gggccccacc aggccacaca ggtccctgag ggtacggcca gcaagtgggg cctggtggct     2340

gaccggctgc tggacctagc ggccagcttc tcggctgtcc tcacccgaat ccaggtgttc     2400

gttcggcgct tgctagaact tcacgtcttc aagctggtgg ccctctacac tgtctgggtg     2460

gccctgaaag aagtgtctgt gatgaacctg ctgctggtgg tgctatgggc cttcgccttg     2520

ccctatccgc gcttccggcc catggcttcc tgcctgtcca ccgtgtggac ctgtatcatc     2580

attgtatgca agatgctcta tcagctcaag attgtcaacc cgcatgagta ctccagcaac     2640

tgcactgagc ccttccccaa caataccaac ttgcagcctt tggagatcaa ccagtctttg     2700

ctgtaccgtg gccctgttga ccctgccaac tggtttgggg tgcggaaggg ttaccccaac     2760

ttgggctata tccagaacca cctgcagatc cttctgttgc tggtgtttga ggccgtggtg     2820

taccggcgcc aagagcacta ccgccggcag caccagcagg cccctctgcc cgcccaggct     2880

gtgtgcgcag atggcacccg ccagaggttg gaccaggacc tacttagctg cctcaagtat     2940

ttcatcaact tcttcttcta caaattcggg ctggagatct gcttcttgat ggccgtgaat     3000

gtgattgggc agcgtatgaa cttcatggtg atcttacacg gttgctggtt ggtggccatc     3060

cttacacgcc ggcgccgtga ggccatcgcc cgcctctggc ctaactactg tctgttcctc     3120

acgctgttcc tgctgtacca gtacctgctg tgtttgggca tgccccctgc actgtgcatt     3180

gactatccat ggcgctggag caaggccatc cccatgaatt ccgccctcat caagtggctg     3240

tacctacctg acttcttcag agcccccaac tccaccaacc ttatcagtga cttcctcctg     3300

ctgctttgcg cctcccagca gtggcaggtc ttctcagcgg agcgaacgga ggagtggcaa     3360

cgcatggcgg gcatcaacac tgaccacctg gagcccctgc gtggggagcc caaccctata     3420

cccaacttca tccactgcag gtcctatctg gatatgctga aggtggccgt cttccgctac     3480

ctgttctggc tggtgctcgt tgtggtgttt gttgcggggg ccacccgcat aagcatcttc     3540

gggctggggt acctgctagc ctgcttctac ctgctgctgt ttggcactac cctgctgcag     3600

aaggacacgc gagcccagct cgtgctgtgg gactgcctca tcctctataa tgtcactgtc     3660

atcatctcta agaatatgct gtcgctcctg tcctgtgtct tcgtggagca aatgcagagc     3720

aacttctgct gggtcatcca gctcttcagc ctcgtgtgca cagtcaaagg ctactatgat     3780

cccaaagaga tgatgaccag ggaccgggac tgcctgctgc ctgtggagga ggccgggatc     3840

atctgggaca gtatctgctt cttcttcctg ctcttgcaac ggcgcatctt tctcagccac     3900

tacttcctgc atgtcagcgc tgacctgaaa gccacagccc tgcaggcatc caggggcttt     3960

gccctctaca atgcagccaa cctgaagagc atcaacttcc atcgccagat tgaggagaag     4020

tccctggccc agctgaaaag acagatgaag cgcatccgtg ccaaacagga gaagtacagg     4080

cagagccagg caagtcgtgg ccaactccag tccaaagacc ctcaggatcc cagccaggag     4140

ccagggcctg acagcccagg gggctcctcc ccgccacgga gacagtggtg gcgcccctgg     4200

ctggaccacg ccacagtcat ccactctggc gactacttcc tgtttgagtc agatagcgag     4260

gaggaagagg aggccctacc tgaggacccc aggcctgcag ctcagagtgc cttccagatg     4320

gcataccagg catgggtaac caatgcccag acagtgctga ggcagcgtcg ggagcgggca     4380

cggcaggagc gggcagagca gctggcttct ggaggtgact tgaacccaga tgtggaacca     4440

gtagatgtcc cagaagatga gatggcaggc cgtagccaca tgatgcagcg tgtgctaagc     4500

accatgcagt tcctgtgggt gctgggccag gccacggtag acgggctgac gcgctggctg     4560

cgtgcattca cgaagcacca ccgcaccatg agcgatgtgc tgtgcgcaga gcgctacctg     4620

ctcacccagg agcttcttcg ggttggagag gtacgccgag gtgtgctgga ccagctttat     4680

gtgggtgaag atgaggccac attgtcaggt cccgtggaga cccgggatgg acccagcaca     4740

gcctcaagtg ggctgggagc cgaagagcct ttgagtagca tgacagacga caccagcagc     4800

cccctgagca caggctataa cacccgcagt ggcagtgagg agattgtcac cgacgctggg     4860

gacctccagg ctgggacctc cctgcacggc tcccaagagc ttttagccaa tgctcgtacc     4920

cggatgcgca cggccagcga gctgctactg gataggcgcc tgcatatccc tgagctggag     4980

gaggccgagc ggtttgaggc acagcagggc cggactctgc ggctgctcag ggctgggtac     5040

cagtgcgtgg cggcacactc ggagctgctc tgttacttca tcatcatcct taaccacatg     5100

gtgacagcct cggctgcctc cctggtgctg cccgtgcttg tgttcctgtg ggccatgctg     5160

accatcccga ggcctagcaa gcgcttttgg atgacagcta tcgtcttcac tgaggtcatg     5220

gtggtcacca aatacctgtt ccagttcggc ttcttcccct ggaacagcta cgttgtgctg     5280

cggcgctatg agaacaagcc ctacttccct ccgcgaatcc tgggccttga gaaaacggac     5340

agctacatca agtatgacct ggtgcagctc atggccctct tcttccaccg ctcgcagcta     5400

ctgtgttatg gcctctggga ccatgaggag gatcgctatc ccaaggacca ttgcaggagt     5460

agtgtgaagg accgggaggc caaggaagag ccagaagcta agctggaatc gcagtctgag     5520

acaggcactg ggcatcccaa ggagccagtg ttggccggta ctcccaggga ccacatccaa     5580

gggaaaggaa gtattagatc caaggatgtt atccaagatc ccccagagga ccttaagccc     5640

cggcacacga ggcacatcag catacgcttc aggaggcgca aggagactcc aggacccaaa     5700

ggaacagcag tcatggagac tgagcacgag gagggagaag gaaaagaaac tacagagaga     5760

aagaggccgc gtcacactca agaaaaatcg aagtttcggg agagaatgaa ggcagctggg     5820

cgccggctgc agagcttctg tgtgtcactg gcccagagct tctaccaacc cttgcagcgt     5880

ttcttccatg acattctgca cacaaagtac cgggcggcca ccgacgtcta cgccctcatg     5940

ttcctggccg atattgtcga catcatcatc atcatctttg gtttttgggc ttttgggaag     6000

cactctgcag ccacagacat tgcatcctcg ctgtcagatg accaggtgcc acaggccttc     6060

ctgttcatgc tgctggtcca gtttggcacc atggtcatcg accgtgccct ctacctgcgc     6120

aagactgtcc tgggaaagct ggcctttcag gtggtcctgg tggtggcgat tcacatctgg     6180

atgttcttta tcttaccggc tgtcactgag aggatgttca gccagaatgc ggtggcacag     6240

ctgtggtact tcgtcaagtg catttacttt gccctgtccg cctaccagat ccgctgtggc     6300

taccccaccc gtatcttggg caacttcctc accaagaaat acaaccatct aaacctcttc     6360

cttttccagg ggttccgtct agtgccgttc ctggtggagc tgcgggccgt catggactgg     6420

gtgtggaccg acaccacgct gtccctgtcc aactggatgt gtgtggaaga catctatgcc     6480

aacatcttta tcatcaagtg cagccgagag acagagaaga aataccccca gcccaagggg     6540

cagaagaaga agaaaattgt caagtatggt atgggaggcc tcattatcct cttcctcatc     6600

gccatcatct ggttccctct gctcttcatg tcactgatcc gctctgtggt cggggtcgtc     6660

aaccagccca ttgatgtcac cgtcaccctc aagctaggcg gctatgagcc actgttcacc     6720

atgagcgccc agcagccatc cattgtgcca ttcacacccc aggcctacga ggagctgtcc     6780

cagcagtttg acccctatcc actagccatg cagttcatta gccagtacag tcctgaggac     6840

atcgtcactg cacagatcga gggcagctcg ggggcgctgt ggcgcatcag cccacccagc     6900

cgagcccaga tgaagcagga gctgtacaac ggcacagccg acattacact gcgctttacc     6960

tggaatttcc aaagggacct ggccaagggt ggcactgtgg agtatactaa tgagaagcac     7020

accttggagc tggcccccaa cagtacggca cgaaggcagc tggcccaact gctcgagggc     7080

agacctgacc agtcagtggt cattccccat ctcttcccca agtacattcg tgctcccaat     7140

gggcctgaag ccaaccctgt gaagcagctg cagccagatg aggaagagga ctaccttggt     7200

gtgcgcatcc agctgcggag ggagcaagtg ggcacagggg cctctgggga gcaagcgggc     7260

accaaggcct ccgacttcct cgagtggtgg gtcatcgagc tgcaggactg caaggctgac     7320

tgcaacctgc tgcccatggt catcttcagt gacaaggtca gcccacctag cctgggcttc     7380

ctggccggct acgggattgt ggggctgtac gtctccatcg tgctggtggt tggcaagttt     7440

gtgcggggct tcttcagcga gatctctcac tccatcatgt tcgaggaact gccgtgtgtg     7500

gaccgcatcc tcaagctgtg ccaggacatc ttcttggtgc gcgagacccg ggagctggag     7560

ctggaggagg agctatacgc caagctcatc ttcctgtacc gatctccaga gaccatgatt     7620

aagtggacac gtgagaggga gtag                                            7644


<210>  2
<211>  2547
<212>  PRT
<213>  Mus musculus

<400>  2

Met Glu Pro His Val Leu Gly Ala Gly Leu Tyr Trp Leu Leu Leu Pro 
1               5                   10                  15      


Cys Thr Leu Leu Ala Ala Ser Leu Leu Arg Phe Asn Ala Leu Ser Leu 
            20                  25                  30          


Val Tyr Leu Leu Phe Leu Leu Leu Leu Pro Trp Leu Pro Gly Pro Ser 
        35                  40                  45              


Arg His Ser Ile Pro Gly His Thr Gly Arg Leu Leu Arg Ala Leu Leu 
    50                  55                  60                  


Cys Leu Ser Leu Leu Phe Leu Val Ala His Leu Ala Phe Gln Ile Cys 
65                  70                  75                  80  


Leu His Thr Val Pro His Leu Asp Gln Phe Leu Gly Gln Asn Gly Ser 
                85                  90                  95      


Leu Trp Val Lys Val Ser Gln His Ile Gly Val Thr Arg Leu Asp Leu 
            100                 105                 110         


Lys Asp Ile Phe Asn Thr Thr Arg Leu Val Ala Pro Asp Leu Gly Val 
        115                 120                 125             


Leu Leu Ala Ser Ser Leu Cys Leu Gly Leu Cys Gly Arg Leu Thr Arg 
    130                 135                 140                 


Lys Ala Gly Gln Ser Arg Arg Thr Gln Glu Leu Gln Asp Asp Asp Asp 
145                 150                 155                 160 


Asp Asp Asp Asp Asp Asp Glu Asp Ile Asp Ala Ala Pro Ala Val Gly 
                165                 170                 175     


Leu Lys Gly Ala Pro Ala Leu Ala Thr Lys Arg Arg Leu Trp Leu Ala 
            180                 185                 190         


Ser Arg Phe Arg Val Thr Ala His Trp Leu Leu Met Thr Ser Gly Arg 
        195                 200                 205             


Thr Leu Val Ile Val Leu Leu Ala Leu Ala Gly Ile Ala His Pro Ser 
    210                 215                 220                 


Ala Phe Ser Ser Ile Tyr Leu Val Val Phe Leu Ala Ile Cys Thr Trp 
225                 230                 235                 240 


Trp Ser Cys His Phe Pro Leu Ser Pro Leu Gly Phe Asn Thr Leu Cys 
                245                 250                 255     


Val Met Val Ser Cys Phe Gly Ala Gly His Leu Ile Cys Leu Tyr Cys 
            260                 265                 270         


Tyr Gln Thr Pro Phe Ile Gln Asp Met Leu Pro Pro Gly Asn Ile Trp 
        275                 280                 285             


Ala Arg Leu Phe Gly Leu Lys Asn Phe Val Asp Leu Pro Asn Tyr Ser 
    290                 295                 300                 


Ser Pro Asn Ala Leu Val Leu Asn Thr Lys His Ala Trp Pro Ile Tyr 
305                 310                 315                 320 


Val Ser Pro Gly Ile Leu Leu Leu Leu Tyr Tyr Thr Ala Thr Ser Leu 
                325                 330                 335     


Leu Lys Leu His Lys Ser Cys Pro Ser Glu Leu Arg Lys Glu Thr Pro 
            340                 345                 350         


Arg Glu Asp Glu Glu His Glu Leu Glu Leu Asp His Leu Glu Pro Glu 
        355                 360                 365             


Pro Gln Ala Arg Asp Ala Thr Gln Gly Glu Met Pro Met Thr Thr Glu 
    370                 375                 380                 


Pro Asp Leu Asp Asn Cys Thr Val His Val Leu Thr Ser Gln Ser Pro 
385                 390                 395                 400 


Val Arg Gln Arg Pro Val Arg Pro Arg Leu Ala Glu Leu Lys Glu Met 
                405                 410                 415     


Ser Pro Leu His Gly Leu Gly His Leu Ile Met Asp Gln Ser Tyr Val 
            420                 425                 430         


Cys Ala Leu Ile Ala Met Met Val Trp Ser Ile Met Tyr His Ser Trp 
        435                 440                 445             


Leu Thr Phe Val Leu Leu Leu Trp Ala Cys Leu Ile Trp Thr Val Arg 
    450                 455                 460                 


Ser Arg His Gln Leu Ala Met Leu Cys Ser Pro Cys Ile Leu Leu Tyr 
465                 470                 475                 480 


Gly Leu Thr Leu Cys Cys Leu Arg Tyr Val Trp Ala Met Glu Leu Pro 
                485                 490                 495     


Glu Leu Pro Thr Thr Leu Gly Pro Val Ser Leu His Gln Leu Gly Leu 
            500                 505                 510         


Glu His Thr Arg Tyr Pro Cys Leu Asp Leu Gly Ala Met Leu Leu Tyr 
        515                 520                 525             


Leu Leu Thr Phe Trp Leu Leu Leu Arg Gln Phe Val Lys Glu Lys Leu 
    530                 535                 540                 


Leu Lys Lys Gln Lys Val Pro Ala Ala Leu Leu Glu Val Thr Val Ala 
545                 550                 555                 560 


Asp Thr Glu Pro Thr Gln Thr Gln Thr Leu Leu Arg Ser Leu Gly Glu 
                565                 570                 575     


Leu Val Thr Gly Ile Tyr Val Lys Tyr Trp Ile Tyr Val Cys Ala Gly 
            580                 585                 590         


Met Phe Ile Val Val Ser Phe Ala Gly Arg Leu Val Val Tyr Lys Ile 
        595                 600                 605             


Val Tyr Met Phe Leu Phe Leu Leu Cys Leu Thr Leu Phe Gln Val Tyr 
    610                 615                 620                 


Tyr Thr Leu Trp Arg Lys Leu Leu Arg Val Phe Trp Trp Leu Val Val 
625                 630                 635                 640 


Ala Tyr Thr Met Leu Val Leu Ile Ala Val Tyr Thr Phe Gln Phe Gln 
                645                 650                 655     


Asp Phe Pro Thr Tyr Trp Arg Asn Leu Thr Gly Phe Thr Asp Glu Gln 
            660                 665                 670         


Leu Gly Asp Leu Gly Leu Glu Gln Phe Ser Val Ser Glu Leu Phe Ser 
        675                 680                 685             


Ser Ile Leu Ile Pro Gly Phe Phe Leu Leu Ala Cys Ile Leu Gln Leu 
    690                 695                 700                 


His Tyr Phe His Arg Pro Phe Met Gln Leu Thr Asp Leu Glu His Val 
705                 710                 715                 720 


Pro Pro Pro Gly Thr Arg His Pro Arg Trp Ala His Arg Gln Asp Ala 
                725                 730                 735     


Val Ser Glu Ala Pro Leu Leu Glu His Gln Glu Glu Glu Glu Val Phe 
            740                 745                 750         


Arg Glu Asp Gly Gln Ser Met Asp Gly Pro His Gln Ala Thr Gln Val 
        755                 760                 765             


Pro Glu Gly Thr Ala Ser Lys Trp Gly Leu Val Ala Asp Arg Leu Leu 
    770                 775                 780                 


Asp Leu Ala Ala Ser Phe Ser Ala Val Leu Thr Arg Ile Gln Val Phe 
785                 790                 795                 800 


Val Arg Arg Leu Leu Glu Leu His Val Phe Lys Leu Val Ala Leu Tyr 
                805                 810                 815     


Thr Val Trp Val Ala Leu Lys Glu Val Ser Val Met Asn Leu Leu Leu 
            820                 825                 830         


Val Val Leu Trp Ala Phe Ala Leu Pro Tyr Pro Arg Phe Arg Pro Met 
        835                 840                 845             


Ala Ser Cys Leu Ser Thr Val Trp Thr Cys Ile Ile Ile Val Cys Lys 
    850                 855                 860                 


Met Leu Tyr Gln Leu Lys Ile Val Asn Pro His Glu Tyr Ser Ser Asn 
865                 870                 875                 880 


Cys Thr Glu Pro Phe Pro Asn Asn Thr Asn Leu Gln Pro Leu Glu Ile 
                885                 890                 895     


Asn Gln Ser Leu Leu Tyr Arg Gly Pro Val Asp Pro Ala Asn Trp Phe 
            900                 905                 910         


Gly Val Arg Lys Gly Tyr Pro Asn Leu Gly Tyr Ile Gln Asn His Leu 
        915                 920                 925             


Gln Ile Leu Leu Leu Leu Val Phe Glu Ala Val Val Tyr Arg Arg Gln 
    930                 935                 940                 


Glu His Tyr Arg Arg Gln His Gln Gln Ala Pro Leu Pro Ala Gln Ala 
945                 950                 955                 960 


Val Cys Ala Asp Gly Thr Arg Gln Arg Leu Asp Gln Asp Leu Leu Ser 
                965                 970                 975     


Cys Leu Lys Tyr Phe Ile Asn Phe Phe Phe Tyr Lys Phe Gly Leu Glu 
            980                 985                 990         


Ile Cys Phe Leu Met Ala Val Asn  Val Ile Gly Gln Arg  Met Asn Phe 
        995                 1000                 1005             


Met Val  Ile Leu His Gly Cys  Trp Leu Val Ala Ile  Leu Thr Arg 
    1010                 1015                 1020             


Arg Arg  Arg Glu Ala Ile Ala  Arg Leu Trp Pro Asn  Tyr Cys Leu 
    1025                 1030                 1035             


Phe Leu  Thr Leu Phe Leu Leu  Tyr Gln Tyr Leu Leu  Cys Leu Gly 
    1040                 1045                 1050             


Met Pro  Pro Ala Leu Cys Ile  Asp Tyr Pro Trp Arg  Trp Ser Lys 
    1055                 1060                 1065             


Ala Ile  Pro Met Asn Ser Ala  Leu Ile Lys Trp Leu  Tyr Leu Pro 
    1070                 1075                 1080             


Asp Phe  Phe Arg Ala Pro Asn  Ser Thr Asn Leu Ile  Ser Asp Phe 
    1085                 1090                 1095             


Leu Leu  Leu Leu Cys Ala Ser  Gln Gln Trp Gln Val  Phe Ser Ala 
    1100                 1105                 1110             


Glu Arg  Thr Glu Glu Trp Gln  Arg Met Ala Gly Ile  Asn Thr Asp 
    1115                 1120                 1125             


His Leu  Glu Pro Leu Arg Gly  Glu Pro Asn Pro Ile  Pro Asn Phe 
    1130                 1135                 1140             


Ile His  Cys Arg Ser Tyr Leu  Asp Met Leu Lys Val  Ala Val Phe 
    1145                 1150                 1155             


Arg Tyr  Leu Phe Trp Leu Val  Leu Val Val Val Phe  Val Ala Gly 
    1160                 1165                 1170             


Ala Thr  Arg Ile Ser Ile Phe  Gly Leu Gly Tyr Leu  Leu Ala Cys 
    1175                 1180                 1185             


Phe Tyr  Leu Leu Leu Phe Gly  Thr Thr Leu Leu Gln  Lys Asp Thr 
    1190                 1195                 1200             


Arg Ala  Gln Leu Val Leu Trp  Asp Cys Leu Ile Leu  Tyr Asn Val 
    1205                 1210                 1215             


Thr Val  Ile Ile Ser Lys Asn  Met Leu Ser Leu Leu  Ser Cys Val 
    1220                 1225                 1230             


Phe Val  Glu Gln Met Gln Ser  Asn Phe Cys Trp Val  Ile Gln Leu 
    1235                 1240                 1245             


Phe Ser  Leu Val Cys Thr Val  Lys Gly Tyr Tyr Asp  Pro Lys Glu 
    1250                 1255                 1260             


Met Met  Thr Arg Asp Arg Asp  Cys Leu Leu Pro Val  Glu Glu Ala 
    1265                 1270                 1275             


Gly Ile  Ile Trp Asp Ser Ile  Cys Phe Phe Phe Leu  Leu Leu Gln 
    1280                 1285                 1290             


Arg Arg  Ile Phe Leu Ser His  Tyr Phe Leu His Val  Ser Ala Asp 
    1295                 1300                 1305             


Leu Lys  Ala Thr Ala Leu Gln  Ala Ser Arg Gly Phe  Ala Leu Tyr 
    1310                 1315                 1320             


Asn Ala  Ala Asn Leu Lys Ser  Ile Asn Phe His Arg  Gln Ile Glu 
    1325                 1330                 1335             


Glu Lys  Ser Leu Ala Gln Leu  Lys Arg Gln Met Lys  Arg Ile Arg 
    1340                 1345                 1350             


Ala Lys  Gln Glu Lys Tyr Arg  Gln Ser Gln Ala Ser  Arg Gly Gln 
    1355                 1360                 1365             


Leu Gln  Ser Lys Asp Pro Gln  Asp Pro Ser Gln Glu  Pro Gly Pro 
    1370                 1375                 1380             


Asp Ser  Pro Gly Gly Ser Ser  Pro Pro Arg Arg Gln  Trp Trp Arg 
    1385                 1390                 1395             


Pro Trp  Leu Asp His Ala Thr  Val Ile His Ser Gly  Asp Tyr Phe 
    1400                 1405                 1410             


Leu Phe  Glu Ser Asp Ser Glu  Glu Glu Glu Glu Ala  Leu Pro Glu 
    1415                 1420                 1425             


Asp Pro  Arg Pro Ala Ala Gln  Ser Ala Phe Gln Met  Ala Tyr Gln 
    1430                 1435                 1440             


Ala Trp  Val Thr Asn Ala Gln  Thr Val Leu Arg Gln  Arg Arg Glu 
    1445                 1450                 1455             


Arg Ala  Arg Gln Glu Arg Ala  Glu Gln Leu Ala Ser  Gly Gly Asp 
    1460                 1465                 1470             


Leu Asn  Pro Asp Val Glu Pro  Val Asp Val Pro Glu  Asp Glu Met 
    1475                 1480                 1485             


Ala Gly  Arg Ser His Met Met  Gln Arg Val Leu Ser  Thr Met Gln 
    1490                 1495                 1500             


Phe Leu  Trp Val Leu Gly Gln  Ala Thr Val Asp Gly  Leu Thr Arg 
    1505                 1510                 1515             


Trp Leu  Arg Ala Phe Thr Lys  His His Arg Thr Met  Ser Asp Val 
    1520                 1525                 1530             


Leu Cys  Ala Glu Arg Tyr Leu  Leu Thr Gln Glu Leu  Leu Arg Val 
    1535                 1540                 1545             


Gly Glu  Val Arg Arg Gly Val  Leu Asp Gln Leu Tyr  Val Gly Glu 
    1550                 1555                 1560             


Asp Glu  Ala Thr Leu Ser Gly  Pro Val Glu Thr Arg  Asp Gly Pro 
    1565                 1570                 1575             


Ser Thr  Ala Ser Ser Gly Leu  Gly Ala Glu Glu Pro  Leu Ser Ser 
    1580                 1585                 1590             


Met Thr  Asp Asp Thr Ser Ser  Pro Leu Ser Thr Gly  Tyr Asn Thr 
    1595                 1600                 1605             


Arg Ser  Gly Ser Glu Glu Ile  Val Thr Asp Ala Gly  Asp Leu Gln 
    1610                 1615                 1620             


Ala Gly  Thr Ser Leu His Gly  Ser Gln Glu Leu Leu  Ala Asn Ala 
    1625                 1630                 1635             


Arg Thr  Arg Met Arg Thr Ala  Ser Glu Leu Leu Leu  Asp Arg Arg 
    1640                 1645                 1650             


Leu His  Ile Pro Glu Leu Glu  Glu Ala Glu Arg Phe  Glu Ala Gln 
    1655                 1660                 1665             


Gln Gly  Arg Thr Leu Arg Leu  Leu Arg Ala Gly Tyr  Gln Cys Val 
    1670                 1675                 1680             


Ala Ala  His Ser Glu Leu Leu  Cys Tyr Phe Ile Ile  Ile Leu Asn 
    1685                 1690                 1695             


His Met  Val Thr Ala Ser Ala  Ala Ser Leu Val Leu  Pro Val Leu 
    1700                 1705                 1710             


Val Phe  Leu Trp Ala Met Leu  Thr Ile Pro Arg Pro  Ser Lys Arg 
    1715                 1720                 1725             


Phe Trp  Met Thr Ala Ile Val  Phe Thr Glu Val Met  Val Val Thr 
    1730                 1735                 1740             


Lys Tyr  Leu Phe Gln Phe Gly  Phe Phe Pro Trp Asn  Ser Tyr Val 
    1745                 1750                 1755             


Val Leu  Arg Arg Tyr Glu Asn  Lys Pro Tyr Phe Pro  Pro Arg Ile 
    1760                 1765                 1770             


Leu Gly  Leu Glu Lys Thr Asp  Ser Tyr Ile Lys Tyr  Asp Leu Val 
    1775                 1780                 1785             


Gln Leu  Met Ala Leu Phe Phe  His Arg Ser Gln Leu  Leu Cys Tyr 
    1790                 1795                 1800             


Gly Leu  Trp Asp His Glu Glu  Asp Arg Tyr Pro Lys  Asp His Cys 
    1805                 1810                 1815             


Arg Ser  Ser Val Lys Asp Arg  Glu Ala Lys Glu Glu  Pro Glu Ala 
    1820                 1825                 1830             


Lys Leu  Glu Ser Gln Ser Glu  Thr Gly Thr Gly His  Pro Lys Glu 
    1835                 1840                 1845             


Pro Val  Leu Ala Gly Thr Pro  Arg Asp His Ile Gln  Gly Lys Gly 
    1850                 1855                 1860             


Ser Ile  Arg Ser Lys Asp Val  Ile Gln Asp Pro Pro  Glu Asp Leu 
    1865                 1870                 1875             


Lys Pro  Arg His Thr Arg His  Ile Ser Ile Arg Phe  Arg Arg Arg 
    1880                 1885                 1890             


Lys Glu  Thr Pro Gly Pro Lys  Gly Thr Ala Val Met  Glu Thr Glu 
    1895                 1900                 1905             


His Glu  Glu Gly Glu Gly Lys  Glu Thr Thr Glu Arg  Lys Arg Pro 
    1910                 1915                 1920             


Arg His  Thr Gln Glu Lys Ser  Lys Phe Arg Glu Arg  Met Lys Ala 
    1925                 1930                 1935             


Ala Gly  Arg Arg Leu Gln Ser  Phe Cys Val Ser Leu  Ala Gln Ser 
    1940                 1945                 1950             


Phe Tyr  Gln Pro Leu Gln Arg  Phe Phe His Asp Ile  Leu His Thr 
    1955                 1960                 1965             


Lys Tyr  Arg Ala Ala Thr Asp  Val Tyr Ala Leu Met  Phe Leu Ala 
    1970                 1975                 1980             


Asp Ile  Val Asp Ile Ile Ile  Ile Ile Phe Gly Phe  Trp Ala Phe 
    1985                 1990                 1995             


Gly Lys  His Ser Ala Ala Thr  Asp Ile Ala Ser Ser  Leu Ser Asp 
    2000                 2005                 2010             


Asp Gln  Val Pro Gln Ala Phe  Leu Phe Met Leu Leu  Val Gln Phe 
    2015                 2020                 2025             


Gly Thr  Met Val Ile Asp Arg  Ala Leu Tyr Leu Arg  Lys Thr Val 
    2030                 2035                 2040             


Leu Gly  Lys Leu Ala Phe Gln  Val Val Leu Val Val  Ala Ile His 
    2045                 2050                 2055             


Ile Trp  Met Phe Phe Ile Leu  Pro Ala Val Thr Glu  Arg Met Phe 
    2060                 2065                 2070             


Ser Gln  Asn Ala Val Ala Gln  Leu Trp Tyr Phe Val  Lys Cys Ile 
    2075                 2080                 2085             


Tyr Phe  Ala Leu Ser Ala Tyr  Gln Ile Arg Cys Gly  Tyr Pro Thr 
    2090                 2095                 2100             


Arg Ile  Leu Gly Asn Phe Leu  Thr Lys Lys Tyr Asn  His Leu Asn 
    2105                 2110                 2115             


Leu Phe  Leu Phe Gln Gly Phe  Arg Leu Val Pro Phe  Leu Val Glu 
    2120                 2125                 2130             


Leu Arg  Ala Val Met Asp Trp  Val Trp Thr Asp Thr  Thr Leu Ser 
    2135                 2140                 2145             


Leu Ser  Asn Trp Met Cys Val  Glu Asp Ile Tyr Ala  Asn Ile Phe 
    2150                 2155                 2160             


Ile Ile  Lys Cys Ser Arg Glu  Thr Glu Lys Lys Tyr  Pro Gln Pro 
    2165                 2170                 2175             


Lys Gly  Gln Lys Lys Lys Lys  Ile Val Lys Tyr Gly  Met Gly Gly 
    2180                 2185                 2190             


Leu Ile  Ile Leu Phe Leu Ile  Ala Ile Ile Trp Phe  Pro Leu Leu 
    2195                 2200                 2205             


Phe Met  Ser Leu Ile Arg Ser  Val Val Gly Val Val  Asn Gln Pro 
    2210                 2215                 2220             


Ile Asp  Val Thr Val Thr Leu  Lys Leu Gly Gly Tyr  Glu Pro Leu 
    2225                 2230                 2235             


Phe Thr  Met Ser Ala Gln Gln  Pro Ser Ile Val Pro  Phe Thr Pro 
    2240                 2245                 2250             


Gln Ala  Tyr Glu Glu Leu Ser  Gln Gln Phe Asp Pro  Tyr Pro Leu 
    2255                 2260                 2265             


Ala Met  Gln Phe Ile Ser Gln  Tyr Ser Pro Glu Asp  Ile Val Thr 
    2270                 2275                 2280             


Ala Gln  Ile Glu Gly Ser Ser  Gly Ala Leu Trp Arg  Ile Ser Pro 
    2285                 2290                 2295             


Pro Ser  Arg Ala Gln Met Lys  Gln Glu Leu Tyr Asn  Gly Thr Ala 
    2300                 2305                 2310             


Asp Ile  Thr Leu Arg Phe Thr  Trp Asn Phe Gln Arg  Asp Leu Ala 
    2315                 2320                 2325             


Lys Gly  Gly Thr Val Glu Tyr  Thr Asn Glu Lys His  Thr Leu Glu 
    2330                 2335                 2340             


Leu Ala  Pro Asn Ser Thr Ala  Arg Arg Gln Leu Ala  Gln Leu Leu 
    2345                 2350                 2355             


Glu Gly  Arg Pro Asp Gln Ser  Val Val Ile Pro His  Leu Phe Pro 
    2360                 2365                 2370             


Lys Tyr  Ile Arg Ala Pro Asn  Gly Pro Glu Ala Asn  Pro Val Lys 
    2375                 2380                 2385             


Gln Leu  Gln Pro Asp Glu Glu  Glu Asp Tyr Leu Gly  Val Arg Ile 
    2390                 2395                 2400             


Gln Leu  Arg Arg Glu Gln Val  Gly Thr Gly Ala Ser  Gly Glu Gln 
    2405                 2410                 2415             


Ala Gly  Thr Lys Ala Ser Asp  Phe Leu Glu Trp Trp  Val Ile Glu 
    2420                 2425                 2430             


Leu Gln  Asp Cys Lys Ala Asp  Cys Asn Leu Leu Pro  Met Val Ile 
    2435                 2440                 2445             


Phe Ser  Asp Lys Val Ser Pro  Pro Ser Leu Gly Phe  Leu Ala Gly 
    2450                 2455                 2460             


Tyr Gly  Ile Val Gly Leu Tyr  Val Ser Ile Val Leu  Val Val Gly 
    2465                 2470                 2475             


Lys Phe  Val Arg Gly Phe Phe  Ser Glu Ile Ser His  Ser Ile Met 
    2480                 2485                 2490             


Phe Glu  Glu Leu Pro Cys Val  Asp Arg Ile Leu Lys  Leu Cys Gln 
    2495                 2500                 2505             


Asp Ile  Phe Leu Val Arg Glu  Thr Arg Glu Leu Glu  Leu Glu Glu 
    2510                 2515                 2520             


Glu Leu  Tyr Ala Lys Leu Ile  Phe Leu Tyr Arg Ser  Pro Glu Thr 
    2525                 2530                 2535             


Met Ile  Lys Trp Thr Arg Glu  Arg Glu 
    2540                 2545         


<210>  3
<211>  8469
<212>  DNA
<213>  Mus musculus

<400>  3
atggcttcgg aagtggtgtg cgggctgatc ttcaggctgc tgcttcccat ctgcctggca       60

gtagcatgtg cgttccggta caatgggctc tcctttgtct accttatcta cctcttgctc      120

attcctctgt tctcagaacc aaccaaagca acgatgcaag gacacacagg gcggttgcta      180

cagtccctgt gcatcaccag cctctcattt ctgctgcttc acatcatttt ccacatcaca      240

ctggccagtc tggaagctca acaccgcatc acacctgctt acaactgctc aacatgggaa      300

aagaccttcc ggcagattgg ctttgaaagc ttgaagggag ctgatgccgg caatggcatc      360

agggtatttg tgcctgatat cgggatgttc attgcaagtc tgaccatctg gctggtctgc      420

agaaccattg ttaagaaacc agacacagaa gaaatagccc aattgaattc tgagtgtgaa      480

aatgaagaat tggctggagg agaaaagatg gattcagagg aggcgctgat ttatgaagag      540

gacttagatg gagaagaagg catggaagga gagctagaag aaagcacaaa actaaaaata      600

cttcgcaggt tcgcctctgt cgcctccaaa ctgaaggagt tcattggcaa tatgatcacc      660

acggcgggca aggtcgtggt gaccatccta ctgggctcct cgggcatgat gctgccatct      720

ttgacctcgg ctgtgtactt ctttgtattt ctgggcctgt gtacctggtg gtcctggtgc      780

cgaactttcg acccattgct gttcggctgc ctctgtgtcc tgctggcaat cttcactgct      840

gggcacctga ttggacttta tctgtaccag ttccaattct tccaagaagc ggtcccgccc      900

aatgactact atgcaaggtt gtttgggatc aagtccgtta tccagacaga ctgtgccagc      960

acctggaaga tcatagtaaa cccagacctg tcctggtatc accatgccaa ccccatcctc     1020

ctgctggtga tgtactatac gctggccacg ctgattcgca tctggctaca agagcctctt     1080

gtgcaagagg agatggcgaa ggaagatgag ggtgccctgg attgcagctc caatcagaac     1140

acggcagaga ggaggcggag cctgtggtat gcaacccagt acccaacaga tgagagaaaa     1200

cttttatcca tgacccaaga tgactacaaa ccatctgatg gcctgctggt gaccgtgaat     1260

ggcaaccctg tggactacca caccatccac ccaagcctgc ccatagagaa tggccctgcc     1320

aagacggacc tgtacaccac tccccagtac cggtgggagc cttcggagga gtcctcagaa     1380

aagaaagagg aagaagagga caagagagaa gactccgaag gggaagggag ccaggaggag     1440

aaaaggagtg tgagaatgca cgccatggtc gccgtgttcc agttcatcat gaagcagagt     1500

tacatctgtg ccctcatcgc catgatggca tggagcatca cctaccacag ctggctgact     1560

ttcgtgctgt tgatctggtc ctgcaccctc tggatgattc gcaacaggag gaagtatgcc     1620

atgatcagtt ctcctttcat ggtcgtctat gcgaatctgc tgctggtgct gcagtacata     1680

tggagcttcg agctccccga gattaagaag gtccccgggt ttctagaaaa gaaagagccg     1740

ggagaacttg cttcaaagat tctcttcacc atcacgttct ggctgctcct gaggcagcat     1800

ctcacagagc agaaggccct gagggaaaag gaagcacttc tttctgaagt caaaattgga     1860

agtcaagaac ttgaagaaaa ggaagatgag gagctccaag atgtacaagt ggaaggggag     1920

cccacagaga aggaagaaga agaggaagag gaaataaagg aagaaaggca tgaggtaaag     1980

aaggaagagg aagaggaagt ggaggaagat gatgaccagg acatcatgaa ggtgctgggt     2040

aatctggtgg tggccctctt catcaagtat tggatctacg tctgcggggg catgttcttt     2100

tttgtcagct ttgaggggaa aatcgtcatg tacaaaatca tctacatggt gctgttcctg     2160

ttctgcgtgg ccttgtacca ggtgcactac gagtggtgga ggaagatcct gaagtacttc     2220

tggatgtcgg tggtcattta taccatgttg gtgctcatct tcatatacac ttaccagttt     2280

gaaaacttcc caggcctgtg gcaaaacatg accggattaa agaaagaaaa gctcgaggac     2340

ctcggcctga agcagttcac ggtcgctgaa ctgttcactc gcatattcat ccccacctcc     2400

tttctactcg tctgcatcct acacctccac tacttccacg atcggttcct ggaacttaca     2460

gacctcaagt ccatccccag caaagaagac aacaccatct acagccatgc caaagtcaat     2520

ggtcgcgtgt acctaataat aaataggttg gcccaccctg aaggaagtct tccagactta     2580

gccatcatga atatgacggc cagccttgat aagcctgagg tgcagaagtt ggcagagtct     2640

ggggaggaga ggccagaaga gtgtgtcaag aagacggaga agggtgaggc tgggaaagac     2700

agtgatgagt ctgaggagga ggaagatgaa gaagaggaat ccgaggaaga agaaagctca     2760

gacctcagga acaagtggca cctggtgatt gaccggctca ctgtgctctt tctaaaattc     2820

ctggagtatt tccacaagtt gcaggtgttt atgtggtgga tcttggagct gcacatcatc     2880

aaaatcgtct catcgtacat tatctgggtg actgtgaaag aggtgtctct gttcaactat     2940

gtatttttga tttcttgggc atttgctctg ccatatgcca aactccgtcg tgcggcttcc     3000

agtgtctgca ctgtctggac atgtgtgatc atcgtctgca aaatgttgta ccagctgcaa     3060

accattaaac ctgagaactt ttctgtcaac tgctccttgc ccaatgaaaa tcaaaccaac     3120

attccccttc atgagttgaa caagtctctt ctctacagtg cccctgttga tcccactgag     3180

tgggtaggcc tgaggaagtc ctctcctttg ctcgtctacc tgaggaacaa cctcctgatg     3240

ctggcgattt tggcctttga agtcaccgtt taccgccatc aggagtacta tcgaggccga     3300

aacaacctga ctgctccagt gtctaaaact atctttcatg acatcacaag gttacatcta     3360

gatgatgggc ttatcaattg tgccaaatat tttgtaaatt acttcttcta caagtttggc     3420

ctagagacct gtttcctaat gtccgtgaat gtaattggac agcgaatgga cttctacgcc     3480

atgattcatg cctgttggtt gatcggtgtc ttgtatcgac gcagaagaaa agccattgcc     3540

gaggtctggc ccaagtactg ctgcttcctg gcttgcatca tcaccttcca gtacttcgtc     3600

tgcatcggca tcccccctgc cccttgccga gattatccat ggagatttaa gggagcctac     3660

ttcaatgata acattatcaa gtggctgtac ttcccggatt tcattgtgcg gcccaacccc     3720

gtgtttcttg tctatgactt catgctgctc ctgtgtgctt ccttacaacg acagatcttt     3780

gaggacgaaa acaaggcagc cgtgcgcatc atggccgggg acaatgtcga gatctgcatg     3840

aaccttgatg cagcctcgtt cagccagcat aaccctgtgc cagatttcat tcactgcaga     3900

tcttacttgg acatgtccaa agtgatcatc ttcagctacc tcttctggtt cgtcctcacc     3960

atcatcttca ttacgggaac aaccaggatc agcatatttt gcatgggcta cttggtggcc     4020

tgtttctatt tcctgctctt tggaggggat ctgctgctga agcccatcaa gagcatcctt     4080

cgttactggg actggctgat tgcatacaac gtgtttgtga tcaccatgaa gaatatactg     4140

tcaataggag cctgtggata cattggcgca ctagtaagaa acagctgctg gttgatccaa     4200

gcgttcagcc tggcctgcac cgtgaaaggc tatcagatgc ctgaagatga ctccagatgc     4260

aagctgccca gtggggaggc agggatcatc tgggacagca tctgctttgc gtttctgctg     4320

ctgcagagga gagtcttcat gagctactac ttcctgcatg tcgtggctga cattaaagca     4380

tcccagatcc tggcatccag aggggccgaa cttttccagg ctacaattgt gaaagctgta     4440

aaggcaagaa ttgaagaaga gaaaaaatcc atggaccagc tgaagagaca gatggatcgc     4500

atcaaagccc ggcaacaaaa gtacaaaaag ggtaaggaga ggatgctgag cttgacccag     4560

gagtcagggg aaggccagga catccagaaa gtctcagaag aagatgatga aagagaagca     4620

gacaaacaga aagccaaggg caaaaaaaag cagtggtggc ggccttgggt tgatcatgct     4680

tccatggtca ggagtggaga ttattatttg tttgaaacgg atagtgaaga ggaggaagaa     4740

gaggaactta aaaaggagga tgaagaaccc ccacggaagt cagcattcca gttcgtctac     4800

caagcctgga ttactgatcc taaaacggca ctccgacaga ggaggaaaga gaagaaaaag     4860

ttggccagag aagagcagaa ggagagacgc aaaggatctg gggacggtcc agtggaatgg     4920

gaagatcgag aggatgagcc agtcaaaaag aaatctgatg gaccagataa tatcatcaar     4980

aggatattta atatcctgaa gttcacatgg gttctgttcc tggccacagt ggatagtttc     5040

accacttggc tcaactccat ctcaagggaa cacatcgaca tatccacagt cctgcggatt     5100

gaaagatgca tgctgactcg agagataaaa aagggcaatg ttccaacacg ggaaagcatc     5160

cacatgtact accagaacca cattatgaac ctttcccgag aatccggcct ggacacaatc     5220

gacgagcact cgggggctgg ctccagggcc caggcagcac ataggatgga tagcttagat     5280

tcccgggaca gtatctccag ctgctacact gaagcgaccc tgctgatctc aaggcagtcc     5340

acccttgatg atttagatgg acaagacccc gttcctaaaa caagcgagcg tgctcggcct     5400

aggctccgta aaatgttcag cctggacatg tcctcttcgt cagctgacag tggcagtgta     5460

gcatcaagcg agcccacaca gtgtaccatg ctgtattcgc gccaaggaac tacggaaacc     5520

atcgaggagg tggaggctga agctgaggag gaggtggtag aaggtctgga gcctgagctc     5580

catgatgcag aagaaaagga atacgcagct gaatatgaag caggggtaga ggagatcagc     5640

ctcactccag atgaggaatt gcctcagttc tctacagatg actgtgaggc gccgccctct     5700

tacagcaagg ctgtcagctt tgagcatcta tcgtttgcgt cgcaagatga ctctggggcc     5760

aagaaccaca tggtggtcag tcctgatgac agccgtacag acaagctgga gtcaagcatc     5820

ttaccacctc tgactcatga gctgacagcc agcgatctgc tgatgagcaa gatgttccat     5880

gatgatgagc ttgaggagtc tgagaagttc tacgtggacc agccccggtt tttgctgcta     5940

ttctatgcca tgtataacac cctggtggcc cgctcagaaa tggtgtgcta tttcgtgatt     6000

atcctgaacc acatgacctc tgcctccatc atcactctcc tgttgcccat cttgatcttc     6060

ctctgggcca tgctgtctgt tcccaggccc agccgacgct tctggatgat ggccatcgtc     6120

tacactgagg tggcgatcgt agtgaaatac ttcttccagt tcggcttctt tccctggaat     6180

aaggacttgg aaatatacaa ggaaaggccc tactttccac cgaacatcat cggggtggag     6240

aagaaggagg gctatgttct ttatgacctc attcagctgc tggctctatt cttccatcgc     6300

tccattctga agtgtcatgg tctatgggac gaggatgaca ttgttgacag taacacagac     6360

aaggaaggat cggatgacga gctgtccctc gatcagggca gaagaggctc ctcagactca     6420

ctgaagtcta tcaacctggc tgcctctgta gagtctgtcc acgtgacctt ccccgagcag     6480

ccagcggcca tcaggagaaa acgctcctgc agtagctctc agatctcccc acggtccagc     6540

ttctcttcaa ataggtccaa aagaggcagc acaagcaccc ggaacagtag ccagaaagga     6600

agcagtgttt taagccttaa acagaaaagc aaacgagaac tttacatgga aaagcttcaa     6660

gagcatttaa tcaaagcaaa ggcgtttacc ataaagaaga ctctacagat ctatgtcccc     6720

attcggcaat tcttctatga cctcatccac ccagactaca gtgctgtgac tgatgtatac     6780

gtgctgatgt ttctggctga cactgtagac ttcattatca tcgtctttgg attctgggcc     6840

tttgggaaac actcggcagc tgcagatatc acctcttctc tatcagaaga ccaggtcccc     6900

gggccattcc tggtgatggt cctcattcag tttggaacca tggtggtgga ccgtgcactc     6960

tacctcagga agactgtgct gggcaaggtc atcttccagg tcatcctcgt gtttgggatt     7020

cacttctgga tgttcttcat cttacccggt gtgactgaga ggaaattcag ccagaacctg     7080

gtggcacagc tttggtactt tgtgaagtgt gtgtactttg ggctgtctgc ctatcaaatc     7140

cgctgtggct acccaacccg tgtgctcggg aacttcctca caaagagcta caattacgtc     7200

aacctcttct tgtttcaagg gttccgcctg gtcccatttc tgactgagct gcgggctgtg     7260

atggattggg tgtggacaga tacaaccctg agcctctcca gctggatttg tgtggaggac     7320

atttacgcgc acatttttat cttaaagtgc tggcgagagt cggaaaagag ataccctcaa     7380

cccaggggtc agaagaagaa gaaagccgtg aagtacggca tgggcggcat gatcatcgtc     7440

cttctcatct gtatcgtctg gtttcctctg ctcttcatgt ctttgatcaa atctgtcgca     7500

ggggttatca accaacccct ggatgtgtcc gtcacaatta ccctgggagg ttatcagcct     7560

atcttcacaa tgagcgccca gcaaagccag ctgaaagtta tggataattc aaagtataat     7620

gaatttctaa aatctttcgg ccccaacagt ggcgcaatgc aatttctgga gaactatgaa     7680

agggaagacg taacagtagc agaactggaa gggaactcga attctttgtg gaccatcagc     7740

cctcccagta agcagaaaat gatacaggag ctcaccgacc ccaatagttg cttctctgtt     7800

gttttttcat ggagtatcca gagaaacatg actttgggtg caaaagccga aatagcaacg     7860

gataagcttt ctttccctct tgcggtcgca acacggaata gcatagctaa aatgattgct     7920

ggcaatgaca cagaaagttc aaacacgcca gtgacaatag agaagatcta cccatactat     7980

gtgaaggcac ccagcgattc aaactcaaag cctataaaac agcttctgtc tgaaaataat     8040

ttcatgaata tcaccatcat tttgttcaga gacaatgtca caaagtccaa tagtgagtgg     8100

tgggttctca acctgaccgg aagtaggata ttcaaccagg ggtcccaagc cttggaactg     8160

gtggtcttca atgacaaagt cagccctcca agtctaggct tcttggctgg ctatggtatc     8220

atgggattgt atgcatctgt tgtccttgta attgggaaat ttgttcgtga gttcttcagt     8280

gggatctctc attccatcat gtttgaagag cttccaaatg tggacagaat cttgaagttg     8340

tgcacagata tattcctcgt gagggagaca ggggagttgg aactggagga agacctctac     8400

gccaagttga tattcctgta caggtcacca gaaaccatga tcaagtggac tagagaaaaa     8460

acaaactga                                                             8469


<210>  4
<211>  2822
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Ser Glu Val Val Cys Gly Leu Ile Phe Arg Leu Leu Leu Pro 
1               5                   10                  15      


Ile Cys Leu Ala Val Ala Cys Ala Phe Arg Tyr Asn Gly Leu Ser Phe 
            20                  25                  30          


Val Tyr Leu Ile Tyr Leu Leu Leu Ile Pro Leu Phe Ser Glu Pro Thr 
        35                  40                  45              


Lys Ala Thr Met Gln Gly His Thr Gly Arg Leu Leu Gln Ser Leu Cys 
    50                  55                  60                  


Ile Thr Ser Leu Ser Phe Leu Leu Leu His Ile Ile Phe His Ile Thr 
65                  70                  75                  80  


Leu Ala Ser Leu Glu Ala Gln His Arg Ile Thr Pro Ala Tyr Asn Cys 
                85                  90                  95      


Ser Thr Trp Glu Lys Thr Phe Arg Gln Ile Gly Phe Glu Ser Leu Lys 
            100                 105                 110         


Gly Ala Asp Ala Gly Asn Gly Ile Arg Val Phe Val Pro Asp Ile Gly 
        115                 120                 125             


Met Phe Ile Ala Ser Leu Thr Ile Trp Leu Val Cys Arg Thr Ile Val 
    130                 135                 140                 


Lys Lys Pro Asp Thr Glu Glu Ile Ala Gln Leu Asn Ser Glu Cys Glu 
145                 150                 155                 160 


Asn Glu Glu Leu Ala Gly Gly Glu Lys Met Asp Ser Glu Glu Ala Leu 
                165                 170                 175     


Ile Tyr Glu Glu Asp Leu Asp Gly Glu Glu Gly Met Glu Gly Glu Leu 
            180                 185                 190         


Glu Glu Ser Thr Lys Leu Lys Ile Leu Arg Arg Phe Ala Ser Val Ala 
        195                 200                 205             


Ser Lys Leu Lys Glu Phe Ile Gly Asn Met Ile Thr Thr Ala Gly Lys 
    210                 215                 220                 


Val Val Val Thr Ile Leu Leu Gly Ser Ser Gly Met Met Leu Pro Ser 
225                 230                 235                 240 


Leu Thr Ser Ala Val Tyr Phe Phe Val Phe Leu Gly Leu Cys Thr Trp 
                245                 250                 255     


Trp Ser Trp Cys Arg Thr Phe Asp Pro Leu Leu Phe Gly Cys Leu Cys 
            260                 265                 270         


Val Leu Leu Ala Ile Phe Thr Ala Gly His Leu Ile Gly Leu Tyr Leu 
        275                 280                 285             


Tyr Gln Phe Gln Phe Phe Gln Glu Ala Val Pro Pro Asn Asp Tyr Tyr 
    290                 295                 300                 


Ala Arg Leu Phe Gly Ile Lys Ser Val Ile Gln Thr Asp Cys Ala Ser 
305                 310                 315                 320 


Thr Trp Lys Ile Ile Val Asn Pro Asp Leu Ser Trp Tyr His His Ala 
                325                 330                 335     


Asn Pro Ile Leu Leu Leu Val Met Tyr Tyr Thr Leu Ala Thr Leu Ile 
            340                 345                 350         


Arg Ile Trp Leu Gln Glu Pro Leu Val Gln Glu Glu Met Ala Lys Glu 
        355                 360                 365             


Asp Glu Gly Ala Leu Asp Cys Ser Ser Asn Gln Asn Thr Ala Glu Arg 
    370                 375                 380                 


Arg Arg Ser Leu Trp Tyr Ala Thr Gln Tyr Pro Thr Asp Glu Arg Lys 
385                 390                 395                 400 


Leu Leu Ser Met Thr Gln Asp Asp Tyr Lys Pro Ser Asp Gly Leu Leu 
                405                 410                 415     


Val Thr Val Asn Gly Asn Pro Val Asp Tyr His Thr Ile His Pro Ser 
            420                 425                 430         


Leu Pro Ile Glu Asn Gly Pro Ala Lys Thr Asp Leu Tyr Thr Thr Pro 
        435                 440                 445             


Gln Tyr Arg Trp Glu Pro Ser Glu Glu Ser Ser Glu Lys Lys Glu Glu 
    450                 455                 460                 


Glu Glu Asp Lys Arg Glu Asp Ser Glu Gly Glu Gly Ser Gln Glu Glu 
465                 470                 475                 480 


Lys Arg Ser Val Arg Met His Ala Met Val Ala Val Phe Gln Phe Ile 
                485                 490                 495     


Met Lys Gln Ser Tyr Ile Cys Ala Leu Ile Ala Met Met Ala Trp Ser 
            500                 505                 510         


Ile Thr Tyr His Ser Trp Leu Thr Phe Val Leu Leu Ile Trp Ser Cys 
        515                 520                 525             


Thr Leu Trp Met Ile Arg Asn Arg Arg Lys Tyr Ala Met Ile Ser Ser 
    530                 535                 540                 


Pro Phe Met Val Val Tyr Ala Asn Leu Leu Leu Val Leu Gln Tyr Ile 
545                 550                 555                 560 


Trp Ser Phe Glu Leu Pro Glu Ile Lys Lys Val Pro Gly Phe Leu Glu 
                565                 570                 575     


Lys Lys Glu Pro Gly Glu Leu Ala Ser Lys Ile Leu Phe Thr Ile Thr 
            580                 585                 590         


Phe Trp Leu Leu Leu Arg Gln His Leu Thr Glu Gln Lys Ala Leu Arg 
        595                 600                 605             


Glu Lys Glu Ala Leu Leu Ser Glu Val Lys Ile Gly Ser Gln Glu Leu 
    610                 615                 620                 


Glu Glu Lys Glu Asp Glu Glu Leu Gln Asp Val Gln Val Glu Gly Glu 
625                 630                 635                 640 


Pro Thr Glu Lys Glu Glu Glu Glu Glu Glu Glu Ile Lys Glu Glu Arg 
                645                 650                 655     


His Glu Val Lys Lys Glu Glu Glu Glu Glu Val Glu Glu Asp Asp Asp 
            660                 665                 670         


Gln Asp Ile Met Lys Val Leu Gly Asn Leu Val Val Ala Leu Phe Ile 
        675                 680                 685             


Lys Tyr Trp Ile Tyr Val Cys Gly Gly Met Phe Phe Phe Val Ser Phe 
    690                 695                 700                 


Glu Gly Lys Ile Val Met Tyr Lys Ile Ile Tyr Met Val Leu Phe Leu 
705                 710                 715                 720 


Phe Cys Val Ala Leu Tyr Gln Val His Tyr Glu Trp Trp Arg Lys Ile 
                725                 730                 735     


Leu Lys Tyr Phe Trp Met Ser Val Val Ile Tyr Thr Met Leu Val Leu 
            740                 745                 750         


Ile Phe Ile Tyr Thr Tyr Gln Phe Glu Asn Phe Pro Gly Leu Trp Gln 
        755                 760                 765             


Asn Met Thr Gly Leu Lys Lys Glu Lys Leu Glu Asp Leu Gly Leu Lys 
    770                 775                 780                 


Gln Phe Thr Val Ala Glu Leu Phe Thr Arg Ile Phe Ile Pro Thr Ser 
785                 790                 795                 800 


Phe Leu Leu Val Cys Ile Leu His Leu His Tyr Phe His Asp Arg Phe 
                805                 810                 815     


Leu Glu Leu Thr Asp Leu Lys Ser Ile Pro Ser Lys Glu Asp Asn Thr 
            820                 825                 830         


Ile Tyr Ser His Ala Lys Val Asn Gly Arg Val Tyr Leu Ile Ile Asn 
        835                 840                 845             


Arg Leu Ala His Pro Glu Gly Ser Leu Pro Asp Leu Ala Ile Met Asn 
    850                 855                 860                 


Met Thr Ala Ser Leu Asp Lys Pro Glu Val Gln Lys Leu Ala Glu Ser 
865                 870                 875                 880 


Gly Glu Glu Arg Pro Glu Glu Cys Val Lys Lys Thr Glu Lys Gly Glu 
                885                 890                 895     


Ala Gly Lys Asp Ser Asp Glu Ser Glu Glu Glu Glu Asp Glu Glu Glu 
            900                 905                 910         


Glu Ser Glu Glu Glu Glu Ser Ser Asp Leu Arg Asn Lys Trp His Leu 
        915                 920                 925             


Val Ile Asp Arg Leu Thr Val Leu Phe Leu Lys Phe Leu Glu Tyr Phe 
    930                 935                 940                 


His Lys Leu Gln Val Phe Met Trp Trp Ile Leu Glu Leu His Ile Ile 
945                 950                 955                 960 


Lys Ile Val Ser Ser Tyr Ile Ile Trp Val Thr Val Lys Glu Val Ser 
                965                 970                 975     


Leu Phe Asn Tyr Val Phe Leu Ile Ser Trp Ala Phe Ala Leu Pro Tyr 
            980                 985                 990         


Ala Lys Leu Arg Arg Ala Ala Ser  Ser Val Cys Thr Val  Trp Thr Cys 
        995                 1000                 1005             


Val Ile  Ile Val Cys Lys Met  Leu Tyr Gln Leu Gln  Thr Ile Lys 
    1010                 1015                 1020             


Pro Glu  Asn Phe Ser Val Asn  Cys Ser Leu Pro Asn  Glu Asn Gln 
    1025                 1030                 1035             


Thr Asn  Ile Pro Leu His Glu  Leu Asn Lys Ser Leu  Leu Tyr Ser 
    1040                 1045                 1050             


Ala Pro  Val Asp Pro Thr Glu  Trp Val Gly Leu Arg  Lys Ser Ser 
    1055                 1060                 1065             


Pro Leu  Leu Val Tyr Leu Arg  Asn Asn Leu Leu Met  Leu Ala Ile 
    1070                 1075                 1080             


Leu Ala  Phe Glu Val Thr Val  Tyr Arg His Gln Glu  Tyr Tyr Arg 
    1085                 1090                 1095             


Gly Arg  Asn Asn Leu Thr Ala  Pro Val Ser Lys Thr  Ile Phe His 
    1100                 1105                 1110             


Asp Ile  Thr Arg Leu His Leu  Asp Asp Gly Leu Ile  Asn Cys Ala 
    1115                 1120                 1125             


Lys Tyr  Phe Val Asn Tyr Phe  Phe Tyr Lys Phe Gly  Leu Glu Thr 
    1130                 1135                 1140             


Cys Phe  Leu Met Ser Val Asn  Val Ile Gly Gln Arg  Met Asp Phe 
    1145                 1150                 1155             


Tyr Ala  Met Ile His Ala Cys  Trp Leu Ile Gly Val  Leu Tyr Arg 
    1160                 1165                 1170             


Arg Arg  Arg Lys Ala Ile Ala  Glu Val Trp Pro Lys  Tyr Cys Cys 
    1175                 1180                 1185             


Phe Leu  Ala Cys Ile Ile Thr  Phe Gln Tyr Phe Val  Cys Ile Gly 
    1190                 1195                 1200             


Ile Pro  Pro Ala Pro Cys Arg  Asp Tyr Pro Trp Arg  Phe Lys Gly 
    1205                 1210                 1215             


Ala Tyr  Phe Asn Asp Asn Ile  Ile Lys Trp Leu Tyr  Phe Pro Asp 
    1220                 1225                 1230             


Phe Ile  Val Arg Pro Asn Pro  Val Phe Leu Val Tyr  Asp Phe Met 
    1235                 1240                 1245             


Leu Leu  Leu Cys Ala Ser Leu  Gln Arg Gln Ile Phe  Glu Asp Glu 
    1250                 1255                 1260             


Asn Lys  Ala Ala Val Arg Ile  Met Ala Gly Asp Asn  Val Glu Ile 
    1265                 1270                 1275             


Cys Met  Asn Leu Asp Ala Ala  Ser Phe Ser Gln His  Asn Pro Val 
    1280                 1285                 1290             


Pro Asp  Phe Ile His Cys Arg  Ser Tyr Leu Asp Met  Ser Lys Val 
    1295                 1300                 1305             


Ile Ile  Phe Ser Tyr Leu Phe  Trp Phe Val Leu Thr  Ile Ile Phe 
    1310                 1315                 1320             


Ile Thr  Gly Thr Thr Arg Ile  Ser Ile Phe Cys Met  Gly Tyr Leu 
    1325                 1330                 1335             


Val Ala  Cys Phe Tyr Phe Leu  Leu Phe Gly Gly Asp  Leu Leu Leu 
    1340                 1345                 1350             


Lys Pro  Ile Lys Ser Ile Leu  Arg Tyr Trp Asp Trp  Leu Ile Ala 
    1355                 1360                 1365             


Tyr Asn  Val Phe Val Ile Thr  Met Lys Asn Ile Leu  Ser Ile Gly 
    1370                 1375                 1380             


Ala Cys  Gly Tyr Ile Gly Ala  Leu Val Arg Asn Ser  Cys Trp Leu 
    1385                 1390                 1395             


Ile Gln  Ala Phe Ser Leu Ala  Cys Thr Val Lys Gly  Tyr Gln Met 
    1400                 1405                 1410             


Pro Glu  Asp Asp Ser Arg Cys  Lys Leu Pro Ser Gly  Glu Ala Gly 
    1415                 1420                 1425             


Ile Ile  Trp Asp Ser Ile Cys  Phe Ala Phe Leu Leu  Leu Gln Arg 
    1430                 1435                 1440             


Arg Val  Phe Met Ser Tyr Tyr  Phe Leu His Val Val  Ala Asp Ile 
    1445                 1450                 1455             


Lys Ala  Ser Gln Ile Leu Ala  Ser Arg Gly Ala Glu  Leu Phe Gln 
    1460                 1465                 1470             


Ala Thr  Ile Val Lys Ala Val  Lys Ala Arg Ile Glu  Glu Glu Lys 
    1475                 1480                 1485             


Lys Ser  Met Asp Gln Leu Lys  Arg Gln Met Asp Arg  Ile Lys Ala 
    1490                 1495                 1500             


Arg Gln  Gln Lys Tyr Lys Lys  Gly Lys Glu Arg Met  Leu Ser Leu 
    1505                 1510                 1515             


Thr Gln  Glu Ser Gly Glu Gly  Gln Asp Ile Gln Lys  Val Ser Glu 
    1520                 1525                 1530             


Glu Asp  Asp Glu Arg Glu Ala  Asp Lys Gln Lys Ala  Lys Gly Lys 
    1535                 1540                 1545             


Lys Lys  Gln Trp Trp Arg Pro  Trp Val Asp His Ala  Ser Met Val 
    1550                 1555                 1560             


Arg Ser  Gly Asp Tyr Tyr Leu  Phe Glu Thr Asp Ser  Glu Glu Glu 
    1565                 1570                 1575             


Glu Glu  Glu Glu Leu Lys Lys  Glu Asp Glu Glu Pro  Pro Arg Lys 
    1580                 1585                 1590             


Ser Ala  Phe Gln Phe Val Tyr  Gln Ala Trp Ile Thr  Asp Pro Lys 
    1595                 1600                 1605             


Thr Ala  Leu Arg Gln Arg Arg  Lys Glu Lys Lys Lys  Leu Ala Arg 
    1610                 1615                 1620             


Glu Glu  Gln Lys Glu Arg Arg  Lys Gly Ser Gly Asp  Gly Pro Val 
    1625                 1630                 1635             


Glu Trp  Glu Asp Arg Glu Asp  Glu Pro Val Lys Lys  Lys Ser Asp 
    1640                 1645                 1650             


Gly Pro  Asp Asn Ile Ile Lys  Arg Ile Phe Asn Ile  Leu Lys Phe 
    1655                 1660                 1665             


Thr Trp  Val Leu Phe Leu Ala  Thr Val Asp Ser Phe  Thr Thr Trp 
    1670                 1675                 1680             


Leu Asn  Ser Ile Ser Arg Glu  His Ile Asp Ile Ser  Thr Val Leu 
    1685                 1690                 1695             


Arg Ile  Glu Arg Cys Met Leu  Thr Arg Glu Ile Lys  Lys Gly Asn 
    1700                 1705                 1710             


Val Pro  Thr Arg Glu Ser Ile  His Met Tyr Tyr Gln  Asn His Ile 
    1715                 1720                 1725             


Met Asn  Leu Ser Arg Glu Ser  Gly Leu Asp Thr Ile  Asp Glu His 
    1730                 1735                 1740             


Ser Gly  Ala Gly Ser Arg Ala  Gln Ala Ala His Arg  Met Asp Ser 
    1745                 1750                 1755             


Leu Asp  Ser Arg Asp Ser Ile  Ser Ser Cys Tyr Thr  Glu Ala Thr 
    1760                 1765                 1770             


Leu Leu  Ile Ser Arg Gln Ser  Thr Leu Asp Asp Leu  Asp Gly Gln 
    1775                 1780                 1785             


Asp Pro  Val Pro Lys Thr Ser  Glu Arg Ala Arg Pro  Arg Leu Arg 
    1790                 1795                 1800             


Lys Met  Phe Ser Leu Asp Met  Ser Ser Ser Ser Ala  Asp Ser Gly 
    1805                 1810                 1815             


Ser Val  Ala Ser Ser Glu Pro  Thr Gln Cys Thr Met  Leu Tyr Ser 
    1820                 1825                 1830             


Arg Gln  Gly Thr Thr Glu Thr  Ile Glu Glu Val Glu  Ala Glu Ala 
    1835                 1840                 1845             


Glu Glu  Glu Val Val Glu Gly  Leu Glu Pro Glu Leu  His Asp Ala 
    1850                 1855                 1860             


Glu Glu  Lys Glu Tyr Ala Ala  Glu Tyr Glu Ala Gly  Val Glu Glu 
    1865                 1870                 1875             


Ile Ser  Leu Thr Pro Asp Glu  Glu Leu Pro Gln Phe  Ser Thr Asp 
    1880                 1885                 1890             


Asp Cys  Glu Ala Pro Pro Ser  Tyr Ser Lys Ala Val  Ser Phe Glu 
    1895                 1900                 1905             


His Leu  Ser Phe Ala Ser Gln  Asp Asp Ser Gly Ala  Lys Asn His 
    1910                 1915                 1920             


Met Val  Val Ser Pro Asp Asp  Ser Arg Thr Asp Lys  Leu Glu Ser 
    1925                 1930                 1935             


Ser Ile  Leu Pro Pro Leu Thr  His Glu Leu Thr Ala  Ser Asp Leu 
    1940                 1945                 1950             


Leu Met  Ser Lys Met Phe His  Asp Asp Glu Leu Glu  Glu Ser Glu 
    1955                 1960                 1965             


Lys Phe  Tyr Val Asp Gln Pro  Arg Phe Leu Leu Leu  Phe Tyr Ala 
    1970                 1975                 1980             


Met Tyr  Asn Thr Leu Val Ala  Arg Ser Glu Met Val  Cys Tyr Phe 
    1985                 1990                 1995             


Val Ile  Ile Leu Asn His Met  Thr Ser Ala Ser Ile  Ile Thr Leu 
    2000                 2005                 2010             


Leu Leu  Pro Ile Leu Ile Phe  Leu Trp Ala Met Leu  Ser Val Pro 
    2015                 2020                 2025             


Arg Pro  Ser Arg Arg Phe Trp  Met Met Ala Ile Val  Tyr Thr Glu 
    2030                 2035                 2040             


Val Ala  Ile Val Val Lys Tyr  Phe Phe Gln Phe Gly  Phe Phe Pro 
    2045                 2050                 2055             


Trp Asn  Lys Asp Leu Glu Ile  Tyr Lys Glu Arg Pro  Tyr Phe Pro 
    2060                 2065                 2070             


Pro Asn  Ile Ile Gly Val Glu  Lys Lys Glu Gly Tyr  Val Leu Tyr 
    2075                 2080                 2085             


Asp Leu  Ile Gln Leu Leu Ala  Leu Phe Phe His Arg  Ser Ile Leu 
    2090                 2095                 2100             


Lys Cys  His Gly Leu Trp Asp  Glu Asp Asp Ile Val  Asp Ser Asn 
    2105                 2110                 2115             


Thr Asp  Lys Glu Gly Ser Asp  Asp Glu Leu Ser Leu  Asp Gln Gly 
    2120                 2125                 2130             


Arg Arg  Gly Ser Ser Asp Ser  Leu Lys Ser Ile Asn  Leu Ala Ala 
    2135                 2140                 2145             


Ser Val  Glu Ser Val His Val  Thr Phe Pro Glu Gln  Pro Ala Ala 
    2150                 2155                 2160             


Ile Arg  Arg Lys Arg Ser Cys  Ser Ser Ser Gln Ile  Ser Pro Arg 
    2165                 2170                 2175             


Ser Ser  Phe Ser Ser Asn Arg  Ser Lys Arg Gly Ser  Thr Ser Thr 
    2180                 2185                 2190             


Arg Asn  Ser Ser Gln Lys Gly  Ser Ser Val Leu Ser  Leu Lys Gln 
    2195                 2200                 2205             


Lys Ser  Lys Arg Glu Leu Tyr  Met Glu Lys Leu Gln  Glu His Leu 
    2210                 2215                 2220             


Ile Lys  Ala Lys Ala Phe Thr  Ile Lys Lys Thr Leu  Gln Ile Tyr 
    2225                 2230                 2235             


Val Pro  Ile Arg Gln Phe Phe  Tyr Asp Leu Ile His  Pro Asp Tyr 
    2240                 2245                 2250             


Ser Ala  Val Thr Asp Val Tyr  Val Leu Met Phe Leu  Ala Asp Thr 
    2255                 2260                 2265             


Val Asp  Phe Ile Ile Ile Val  Phe Gly Phe Trp Ala  Phe Gly Lys 
    2270                 2275                 2280             


His Ser  Ala Ala Ala Asp Ile  Thr Ser Ser Leu Ser  Glu Asp Gln 
    2285                 2290                 2295             


Val Pro  Gly Pro Phe Leu Val  Met Val Leu Ile Gln  Phe Gly Thr 
    2300                 2305                 2310             


Met Val  Val Asp Arg Ala Leu  Tyr Leu Arg Lys Thr  Val Leu Gly 
    2315                 2320                 2325             


Lys Val  Ile Phe Gln Val Ile  Leu Val Phe Gly Ile  His Phe Trp 
    2330                 2335                 2340             


Met Phe  Phe Ile Leu Pro Gly  Val Thr Glu Arg Lys  Phe Ser Gln 
    2345                 2350                 2355             


Asn Leu  Val Ala Gln Leu Trp  Tyr Phe Val Lys Cys  Val Tyr Phe 
    2360                 2365                 2370             


Gly Leu  Ser Ala Tyr Gln Ile  Arg Cys Gly Tyr Pro  Thr Arg Val 
    2375                 2380                 2385             


Leu Gly  Asn Phe Leu Thr Lys  Ser Tyr Asn Tyr Val  Asn Leu Phe 
    2390                 2395                 2400             


Leu Phe  Gln Gly Phe Arg Leu  Val Pro Phe Leu Thr  Glu Leu Arg 
    2405                 2410                 2415             


Ala Val  Met Asp Trp Val Trp  Thr Asp Thr Thr Leu  Ser Leu Ser 
    2420                 2425                 2430             


Ser Trp  Ile Cys Val Glu Asp  Ile Tyr Ala His Ile  Phe Ile Leu 
    2435                 2440                 2445             


Lys Cys  Trp Arg Glu Ser Glu  Lys Arg Tyr Pro Gln  Pro Arg Gly 
    2450                 2455                 2460             


Gln Lys  Lys Lys Lys Ala Val  Lys Tyr Gly Met Gly  Gly Met Ile 
    2465                 2470                 2475             


Ile Val  Leu Leu Ile Cys Ile  Val Trp Phe Pro Leu  Leu Phe Met 
    2480                 2485                 2490             


Ser Leu  Ile Lys Ser Val Ala  Gly Val Ile Asn Gln  Pro Leu Asp 
    2495                 2500                 2505             


Val Ser  Val Thr Ile Thr Leu  Gly Gly Tyr Gln Pro  Ile Phe Thr 
    2510                 2515                 2520             


Met Ser  Ala Gln Gln Ser Gln  Leu Lys Val Met Asp  Asn Ser Lys 
    2525                 2530                 2535             


Tyr Asn  Glu Phe Leu Lys Ser  Phe Gly Pro Asn Ser  Gly Ala Met 
    2540                 2545                 2550             


Gln Phe  Leu Glu Asn Tyr Glu  Arg Glu Asp Val Thr  Val Ala Glu 
    2555                 2560                 2565             


Leu Glu  Gly Asn Ser Asn Ser  Leu Trp Thr Ile Ser  Pro Pro Ser 
    2570                 2575                 2580             


Lys Gln  Lys Met Ile Gln Glu  Leu Thr Asp Pro Asn  Ser Cys Phe 
    2585                 2590                 2595             


Ser Val  Val Phe Ser Trp Ser  Ile Gln Arg Asn Met  Thr Leu Gly 
    2600                 2605                 2610             


Ala Lys  Ala Glu Ile Ala Thr  Asp Lys Leu Ser Phe  Pro Leu Ala 
    2615                 2620                 2625             


Val Ala  Thr Arg Asn Ser Ile  Ala Lys Met Ile Ala  Gly Asn Asp 
    2630                 2635                 2640             


Thr Glu  Ser Ser Asn Thr Pro  Val Thr Ile Glu Lys  Ile Tyr Pro 
    2645                 2650                 2655             


Tyr Tyr  Val Lys Ala Pro Ser  Asp Ser Asn Ser Lys  Pro Ile Lys 
    2660                 2665                 2670             


Gln Leu  Leu Ser Glu Asn Asn  Phe Met Asn Ile Thr  Ile Ile Leu 
    2675                 2680                 2685             


Phe Arg  Asp Asn Val Thr Lys  Ser Asn Ser Glu Trp  Trp Val Leu 
    2690                 2695                 2700             


Asn Leu  Thr Gly Ser Arg Ile  Phe Asn Gln Gly Ser  Gln Ala Leu 
    2705                 2710                 2715             


Glu Leu  Val Val Phe Asn Asp  Lys Val Ser Pro Pro  Ser Leu Gly 
    2720                 2725                 2730             


Phe Leu  Ala Gly Tyr Gly Ile  Met Gly Leu Tyr Ala  Ser Val Val 
    2735                 2740                 2745             


Leu Val  Ile Gly Lys Phe Val  Arg Glu Phe Phe Ser  Gly Ile Ser 
    2750                 2755                 2760             


His Ser  Ile Met Phe Glu Glu  Leu Pro Asn Val Asp  Arg Ile Leu 
    2765                 2770                 2775             


Lys Leu  Cys Thr Asp Ile Phe  Leu Val Arg Glu Thr  Gly Glu Leu 
    2780                 2785                 2790             


Glu Leu  Glu Glu Asp Leu Tyr  Ala Lys Leu Ile Phe  Leu Tyr Arg 
    2795                 2800                 2805             


Ser Pro  Glu Thr Met Ile Lys  Trp Thr Arg Glu Lys  Thr Asn 
    2810                 2815                 2820         


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo1 siRNA

<400>  5
caccggcatc tacgtcaaat a                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo1 siRNA

<400>  6
accaagaaat acaaccatct a                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo1 siRNA

<400>  7
tcggcgcttg ctagaacttc a                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo1 siRNA

<400>  8
cggaatcctg ctgctgctat a                                                 21


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo1 siRNA

<400>  9
gaaagagatg tcaccgcta                                                    19


<210>  10
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo1 siRNA

<400>  10
gcatcaactt ccatcgcca                                                    19


<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo1 siRNA

<400>  11
aaagacagat gaagcgcat                                                    19


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo1 siRNA

<400>  12
ggcaggatgc agtgagcga                                                    19


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo2 siRNA

<400>  13
gaatgtaatt ggacagcga                                                    19


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo2 siRNA

<400>  14
tcatgaaggt gctgggtaa                                                    19


<210>  15
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo2 si RNA

<400>  15
gattatccat ggagattta                                                    19


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Piezo2 siRNA

<400>  16
gaagaaaggc atgaggtaa                                                    19


<210>  17
<211>  7566
<212>  DNA
<213>  Homo sapiens

<400>  17
atggagccgc acgtgctcgg cgcggtcctg tactggctgc tgctgccctg cgcgctgctg       60

gctgcctgcc tgctccgctt cagcggactc tcgctggtct acctgctctt cctgctgctg      120

ctgccctggt tccccggccc cacccgatgc ggcctccaag gtcacacagg ccgcctcctg      180

cgggcattgc tgggcctcag cctgctcttc ctggtggccc atctcgccct ccagatctgc      240

ctgcatattg tgccccgcct ggaccagctc ctgggaccca gctgcagccg ctgggagacc      300

ctctcgcgac acataggggt cacaaggctg gacctgaagg acatccccaa cgccatccgg      360

ctggtggccc ctgacctggg catcttggtg gtctcctctg tctgcctcgg catctgcggg      420

cgccttgcaa ggaacacccg gcagagccca catccacggg agctggatga tgatgagagg      480

gatgtggatg ccagcccgac ggcagggctg caggaagcag caacgctggc ccctacacgg      540

aggtcacggc tggccgctcg tttccgagtc acggcccact ggctgctggt ggcggctggg      600

cgggtcctgg ccgtaacact gcttgcactg gcaggcatcg cccacccctc ggccctctcc      660

agtgtctacc tgctgctctt cctggccctc tgcacctggt gggcctgcca ctttcccatc      720

agcactcggg gcttcagcag actctgcgtc gcggtggggt gcttcggcgc cggccatctc      780

atctgcctct actgctacca gatgcccttg gcacaggctc tgctcccgcc tgccggcatc      840

tgggctaggg tgctgggtct caaggacttc gtgggtccca ccaactgctc cagcccccac      900

gcgctggtcc tcaacaccgg cctggactgg cctgtgtatg ccagccccgg cgtcctcctg      960

ctgctgtgct acgccacggc ctctctgcgc aagctccgcg cgtaccgccc ctccggccag     1020

aggaaggagg cggcaaaggg gtatgaggct cgggagctgg agctagcaga gctggaccag     1080

tggccccagg aacgggagtc tgaccagcac gtggtgccca cagcacccga caccgaggct     1140

gataactgca tcgtgcacga gctgaccggc cagagctccg tcctgcggcg gcctgtgcgg     1200

cccaagcggg ctgagcccag ggaggcgtct ccgctccaca gcctgggcca cctcatcatg     1260

gaccagagct atgtgtgcgc gctcattgcc atgatggtat ggagcatcac ctaccacagc     1320

tggctgacct tcgtactgct gctctgggcc tgcctcatct ggacggtgcg cagccgccac     1380

caactggcca tgctgtgctc gccctgcatc ctgctgtatg ggatgacgct gtgctgccta     1440

cgctacgtgt gggccatgga cctgcgccct gagctgccca ccaccctggg ccccgtcagc     1500

ctgcgccagc tggggctgga gcacacccgc tacccctgtc tggaccttgg tgccatgttg     1560

ctctacaccc tgaccttctg gctcctgctg cgccagtttg tgaaagagaa gctgctgaag     1620

tgggcagagt ctccagctgc gctgacggag gtcaccgtgg cagacacaga gcccacgcgg     1680

acgcagacgc tgttgcagag cctgggggag ctggtgaagg gcgtgtacgc caagtactgg     1740

atctatgtgt gtgctggcat gttcatcgtg gtcagcttcg ccggccgcct cgtggtctac     1800

aagattgtct acatgttcct cttcctgctc tgcctcaccc tcttccaggt ctactacagc     1860

ctgtggcgga agctgctcaa ggccttctgg tggctcgtgg tggcctacac catgctggtc     1920

ctcatcgccg tctacacctt ccagttccag gacttccctg cctactggcg caacctcact     1980

ggcttcaccg acgagcagct gggggacctg ggcctggagc agttcagcgt gtccgagctc     2040

ttctccagca tcctggtgcc cggcttcttc ctcctggcct gcatcctgca gctgcactac     2100

ttccacaggc ccttcatgca gctcaccgac atggagcacg tgtccctgcc tggcacgcgc     2160

ctcccgcgct gggctcacag gcaggatgca gtgagtggga ccccactgct gcgggaggag     2220

cagcaggagc atcagcagca gcagcaggag gaggaggagg aggaggagga ctccagggac     2280

gaggggctgg gcgtggccac tccccaccag gccacgcagg tgcctgaagg ggcagccaag     2340

tggggcctgg tggctgagcg gctgctggag ctggcagccg gcttctcgga cgtcctctca     2400

cgcgtgcagg tgttcctgcg gcggctgctg gagcttcacg ttttcaagct ggtggccctg     2460

tacaccgtct gggtggccct gaaggaggtg tcggtgatga acctgctgct ggtggtgctg     2520

tgggccttcg ccctgcccta cccacgcttc cggcccatgg cctcctgcct gtccaccgtg     2580

tggacctgcg tcatcatcgt gtgtaagatg ctgtaccagc tcaaggttgt caacccccag     2640

gagtattcca gcaactgcac cgagcccttc cccaacagca ccaacttgct gcccacggag     2700

atcagccagt ccctgctgta ccgggggccc gtggaccctg ccaactggtt tggggtgcgg     2760

aaagggttcc ccaacctggg ctacatccag aaccacctgc aagtgctgct gctgctggta     2820

ttcgaggcca tcgtgtaccg gcgccaggag cactaccgcc ggcagcacca gctggccccg     2880

ctgcctgccc aggccgtgtt tgccagcggc acccgccagc agctggacca ggatctgctc     2940

ggctgcctca agtacttcat caacttcttc ttctacaaat tcgggctgga gatctgcttc     3000

ctgatggccg tgaacgtgat cgggcagcgc atgaactttc tggtgaccct gcacggttgc     3060

tggctggtgg ccatcctcac ccgcaggcac cgccaggcca ttgcccgcct ctggcccaac     3120

tactgcctct tcctggcgct gttcctgctg taccagtacc tgctgtgcct ggggatgccc     3180

ccggccctgt gcattgatta tccctggcgc tggagccggg ccgtccccat gaactccgca     3240

ctcatcaagt ggctgtacct gcctgatttc ttccgggccc ccaactccac caacctcatc     3300

agcgactttc tcctgctgct gtgcgcctcc cagcagtggc aggtgttctc agctgagcgc     3360

acagaggagt ggcagcgcat ggctggcgtc aacaccgacc gcctggagcc gctgcggggg     3420

gagcccaacc ccgtgcccaa ctttatccac tgcaggtcct accttgacat gctgaaggtg     3480

gccgtcttcc gatacctgtt ctggctggtg ctggtggtgg tgtttgtcac gggggccacc     3540

cgcatcagca tcttcgggct gggctacctg ctggcctgct tctacctgct gctcttcggc     3600

acggccctgc tgcagaggga cacacgggcc cgcctcgtgc tgtgggactg cctcattctg     3660

tacaacgtca ccgtcatcat ctccaagaac atgctgtcgc tcctggcctg cgtcttcgtg     3720

gagcagatgc agaccggctt ctgctgggtc atccagctct tcagccttgt atgcaccgtc     3780

aagggctact atgaccccaa ggagatgatg gacagagacc aggactgcct gctgcctgtg     3840

gaggaggctg gcatcatctg ggacagcgtc tgcttcttct tcctgctgct gcagcgccgc     3900

gtcttcctta gccattacta cctgcacgtc agggccgacc tccaggccac cgccctgcta     3960

gcctccaggg gcttcgccct ctacaacgct gccaacctca agagcattga ctttcaccgc     4020

aggatagagg agaagtccct ggcccagctg aaaagacaga tggagcgtat ccgtgccaag     4080

caggagaagc acaggcaggg ccgggtggac cgcagtcgcc cccaggacac cctgggcccc     4140

aaggaccccg gcctggagcc agggcccgac agtccagggg gctcctcccc gccacggagg     4200

cagtggtggc ggccctggct ggaccacgcc acagtcatcc actccgggga ctacttcctg     4260

tttgagtccg acagtgagga agaggaggag gctgttcctg aagacccgag gccgtcggca     4320

cagagtgcct tccagctggc gtaccaggca tgggtgacca acgcccaggc ggtgctgagg     4380

cggcggcagc aggagcagga gcaggcaagg caggaacagg caggacagct acccacagga     4440

ggtggtccca gccaggaggt ggagccagca gagggccccg aggaggcagc ggcaggccgg     4500

agccatgtgg tgcagagggt gctgagcacg gcgcagttcc tgtggatgct ggggcaggcg     4560

ctagtggatg agctgacacg ctggctgcag gagttcaccc ggcaccacgg caccatgagc     4620

gacgtgctgc gggcagagcg ctacctcctc acacaggagc tcctgcaggg cggcgaagtg     4680

cacaggggcg tgctggatca gctgtacaca agccaggccg aggccacgct gccaggcccc     4740

accgaggccc ccaatgcccc aagcaccgtg tccagtgggc tgggcgcgga ggagccactc     4800

agcagcatga cagacgacat gggcagcccc ctgagcaccg gctaccacac gcgcagtggc     4860

agtgaggagg cagtcaccga ccccggggag cgtgaggctg gtgcctctct gtaccaggga     4920

ctgatgcgga cggccagcga gctgctcctg gacaggcgcc tgcgcatccc agagctggag     4980

gaggcagagc tgtttgcgga ggggcagggc cgggcgctgc ggctgctgcg ggccgtgtac     5040

cagtgtgtgg ccgcccactc ggagctgctc tgctacttca tcatcatcct caaccacatg     5100

gtcacggcct ccgccggctc gctggtgctg cccgtgctcg tcttcctgtg ggccatgctg     5160

tcgatcccga ggcccagcaa gcgcttctgg atgacggcca tcgtcttcac cgagatcgcg     5220

gtggtcgtca agtacctgtt ccagtttggg ttcttcccct ggaacagcca cgtggtgctg     5280

cggcgctacg agaacaagcc ctacttcccg ccccgcatcc tgggcctgga gaagactgac     5340

ggctacatca agtacgacct ggtgcagctc atggcccttt tcttccaccg ctcccagctg     5400

ctgtgctatg gcctctggga ccatgaggag gactcaccat ccaaggagca tgacaagagc     5460

ggcgaggagg agcagggagc cgaggagggg ccaggggtgc ctgcggccac caccgaagac     5520

cacattcagg tggaagccag ggtcggaccc acggacggga ccccagaacc ccaagtggag     5580

ctcaggcccc gtgatacgag gcgcatcagt ctacgtttta gaagaaggaa gaaggagggc     5640

ccagcacgga aaggagcggc agccatcgaa gctgaggaca gggaggaaga agagggggag     5700

gaagagaaag aggcccccac ggggagagag aagaggccaa gccgctctgg aggaagagta     5760

agggcggccg ggcggcggct gcagggcttc tgcctgtccc tggcccaggg cacatatcgg     5820

ccgctacggc gcttcttcca cgacatcctg cacaccaagt accgcgcagc caccgacgtc     5880

tatgccctca tgttcctggc tgatgttgtc gacttcatca tcatcatttt tggcttctgg     5940

gcctttggga agcactcggc ggccacagac atcacgtcct ccctatcaga cgaccaggta     6000

cccgaggctt tcctggtcat gctgctgatc cagttcagta ccatggtggt tgaccgcgcc     6060

ctctacctgc gcaagaccgt gctgggcaag ctggccttcc aggtggcgct ggtgctggcc     6120

atccacctat ggatgttctt catcctgccc gccgtcactg agaggatgtt caaccagaat     6180

gtggtggccc agctctggta cttcgtgaag tgcatctact tcgccctgtc cgcctaccag     6240

atccgctgcg gctaccccac ccgcatcctc ggcaacttcc tcaccaagaa gtacaatcat     6300

ctcaacctct tcctcttcca ggggttccgg ctggtgccgt tcctggtgga gctgcgggca     6360

gtgatggact gggtgtggac ggacaccacg ctgtccctgt ccagctggat gtgtgtggag     6420

gacatctatg ccaacatctt catcatcaaa tgcagccgag agacagagaa gaaatacccg     6480

cagcccaaag ggcagaagaa gaagaagatc gtcaagtacg gcatgggtgg cctcatcatc     6540

ctcttcctca tcgccatcat ctggttccca ctgctcttca tgtcgctggt gcgctccgtg     6600

gttggggttg tcaaccagcc catcgatgtc accgtcaccc tgaagctggg cggctatgag     6660

ccgctgttca ccatgagcgc ccagcagccg tccatcatcc ccttcacggc ccaggcctat     6720

gaggagctgt cccggcagtt tgacccccag ccgctggcca tgcagttcat cagccagtac     6780

agccctgagg acatcgtcac ggcgcagatt gagggcagct ccggggcgct gtggcgcatc     6840

agtcccccca gccgtgccca gatgaagcgg gagctctaca acggcacggc cgacatcacc     6900

ctgcgcttca cctggaactt ccagagggac ctggcgaagg gaggcactgt ggagtatgcc     6960

aacgagaagc acatgctggc cctggccccc aacagcactg cacggcggca gctggccagc     7020

ctgctcgagg gcacctcgga ccagtctgtg gtcatcccta atctcttccc caagtacatc     7080

cgtgccccca acgggcccga agccaaccct gtgaagcagc tgcagcccaa tgaggaggcc     7140

gactacctcg gcgtgcgtat ccagctgcgg agggagcagg gtgcgggggc caccggcttc     7200

ctcgaatggt gggtcatcga gctgcaggag tgccggaccg actgcaacct gctgcccatg     7260

gtcattttca gtgacaaggt cagcccaccg agcctcggct tcctggctgg ctacggcatc     7320

atggggctgt acgtgtccat cgtgctggtc atcggcaagt tcgtgcgcgg attcttcagc     7380

gagatctcgc actccattat gttcgaggag ctgccgtgcg tggaccgcat cctcaagctc     7440

tgccaggaca tcttcctggt gcgggagact cgggagctgg agctggagga ggagttgtac     7500

gccaagctca tcttcctcta ccgctcaccg gagaccatga tcaagtggac tcgtgagaag     7560

gagtag                                                                7566


<210>  18
<211>  2521
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Pro His Val Leu Gly Ala Val Leu Tyr Trp Leu Leu Leu Pro 
1               5                   10                  15      


Cys Ala Leu Leu Ala Ala Cys Leu Leu Arg Phe Ser Gly Leu Ser Leu 
            20                  25                  30          


Val Tyr Leu Leu Phe Leu Leu Leu Leu Pro Trp Phe Pro Gly Pro Thr 
        35                  40                  45              


Arg Cys Gly Leu Gln Gly His Thr Gly Arg Leu Leu Arg Ala Leu Leu 
    50                  55                  60                  


Gly Leu Ser Leu Leu Phe Leu Val Ala His Leu Ala Leu Gln Ile Cys 
65                  70                  75                  80  


Leu His Ile Val Pro Arg Leu Asp Gln Leu Leu Gly Pro Ser Cys Ser 
                85                  90                  95      


Arg Trp Glu Thr Leu Ser Arg His Ile Gly Val Thr Arg Leu Asp Leu 
            100                 105                 110         


Lys Asp Ile Pro Asn Ala Ile Arg Leu Val Ala Pro Asp Leu Gly Ile 
        115                 120                 125             


Leu Val Val Ser Ser Val Cys Leu Gly Ile Cys Gly Arg Leu Ala Arg 
    130                 135                 140                 


Asn Thr Arg Gln Ser Pro His Pro Arg Glu Leu Asp Asp Asp Glu Arg 
145                 150                 155                 160 


Asp Val Asp Ala Ser Pro Thr Ala Gly Leu Gln Glu Ala Ala Thr Leu 
                165                 170                 175     


Ala Pro Thr Arg Arg Ser Arg Leu Ala Ala Arg Phe Arg Val Thr Ala 
            180                 185                 190         


His Trp Leu Leu Val Ala Ala Gly Arg Val Leu Ala Val Thr Leu Leu 
        195                 200                 205             


Ala Leu Ala Gly Ile Ala His Pro Ser Ala Leu Ser Ser Val Tyr Leu 
    210                 215                 220                 


Leu Leu Phe Leu Ala Leu Cys Thr Trp Trp Ala Cys His Phe Pro Ile 
225                 230                 235                 240 


Ser Thr Arg Gly Phe Ser Arg Leu Cys Val Ala Val Gly Cys Phe Gly 
                245                 250                 255     


Ala Gly His Leu Ile Cys Leu Tyr Cys Tyr Gln Met Pro Leu Ala Gln 
            260                 265                 270         


Ala Leu Leu Pro Pro Ala Gly Ile Trp Ala Arg Val Leu Gly Leu Lys 
        275                 280                 285             


Asp Phe Val Gly Pro Thr Asn Cys Ser Ser Pro His Ala Leu Val Leu 
    290                 295                 300                 


Asn Thr Gly Leu Asp Trp Pro Val Tyr Ala Ser Pro Gly Val Leu Leu 
305                 310                 315                 320 


Leu Leu Cys Tyr Ala Thr Ala Ser Leu Arg Lys Leu Arg Ala Tyr Arg 
                325                 330                 335     


Pro Ser Gly Gln Arg Lys Glu Ala Ala Lys Gly Tyr Glu Ala Arg Glu 
            340                 345                 350         


Leu Glu Leu Ala Glu Leu Asp Gln Trp Pro Gln Glu Arg Glu Ser Asp 
        355                 360                 365             


Gln His Val Val Pro Thr Ala Pro Asp Thr Glu Ala Asp Asn Cys Ile 
    370                 375                 380                 


Val His Glu Leu Thr Gly Gln Ser Ser Val Leu Arg Arg Pro Val Arg 
385                 390                 395                 400 


Pro Lys Arg Ala Glu Pro Arg Glu Ala Ser Pro Leu His Ser Leu Gly 
                405                 410                 415     


His Leu Ile Met Asp Gln Ser Tyr Val Cys Ala Leu Ile Ala Met Met 
            420                 425                 430         


Val Trp Ser Ile Thr Tyr His Ser Trp Leu Thr Phe Val Leu Leu Leu 
        435                 440                 445             


Trp Ala Cys Leu Ile Trp Thr Val Arg Ser Arg His Gln Leu Ala Met 
    450                 455                 460                 


Leu Cys Ser Pro Cys Ile Leu Leu Tyr Gly Met Thr Leu Cys Cys Leu 
465                 470                 475                 480 


Arg Tyr Val Trp Ala Met Asp Leu Arg Pro Glu Leu Pro Thr Thr Leu 
                485                 490                 495     


Gly Pro Val Ser Leu Arg Gln Leu Gly Leu Glu His Thr Arg Tyr Pro 
            500                 505                 510         


Cys Leu Asp Leu Gly Ala Met Leu Leu Tyr Thr Leu Thr Phe Trp Leu 
        515                 520                 525             


Leu Leu Arg Gln Phe Val Lys Glu Lys Leu Leu Lys Trp Ala Glu Ser 
    530                 535                 540                 


Pro Ala Ala Leu Thr Glu Val Thr Val Ala Asp Thr Glu Pro Thr Arg 
545                 550                 555                 560 


Thr Gln Thr Leu Leu Gln Ser Leu Gly Glu Leu Val Lys Gly Val Tyr 
                565                 570                 575     


Ala Lys Tyr Trp Ile Tyr Val Cys Ala Gly Met Phe Ile Val Val Ser 
            580                 585                 590         


Phe Ala Gly Arg Leu Val Val Tyr Lys Ile Val Tyr Met Phe Leu Phe 
        595                 600                 605             


Leu Leu Cys Leu Thr Leu Phe Gln Val Tyr Tyr Ser Leu Trp Arg Lys 
    610                 615                 620                 


Leu Leu Lys Ala Phe Trp Trp Leu Val Val Ala Tyr Thr Met Leu Val 
625                 630                 635                 640 


Leu Ile Ala Val Tyr Thr Phe Gln Phe Gln Asp Phe Pro Ala Tyr Trp 
                645                 650                 655     


Arg Asn Leu Thr Gly Phe Thr Asp Glu Gln Leu Gly Asp Leu Gly Leu 
            660                 665                 670         


Glu Gln Phe Ser Val Ser Glu Leu Phe Ser Ser Ile Leu Val Pro Gly 
        675                 680                 685             


Phe Phe Leu Leu Ala Cys Ile Leu Gln Leu His Tyr Phe His Arg Pro 
    690                 695                 700                 


Phe Met Gln Leu Thr Asp Met Glu His Val Ser Leu Pro Gly Thr Arg 
705                 710                 715                 720 


Leu Pro Arg Trp Ala His Arg Gln Asp Ala Val Ser Gly Thr Pro Leu 
                725                 730                 735     


Leu Arg Glu Glu Gln Gln Glu His Gln Gln Gln Gln Gln Glu Glu Glu 
            740                 745                 750         


Glu Glu Glu Glu Asp Ser Arg Asp Glu Gly Leu Gly Val Ala Thr Pro 
        755                 760                 765             


His Gln Ala Thr Gln Val Pro Glu Gly Ala Ala Lys Trp Gly Leu Val 
    770                 775                 780                 


Ala Glu Arg Leu Leu Glu Leu Ala Ala Gly Phe Ser Asp Val Leu Ser 
785                 790                 795                 800 


Arg Val Gln Val Phe Leu Arg Arg Leu Leu Glu Leu His Val Phe Lys 
                805                 810                 815     


Leu Val Ala Leu Tyr Thr Val Trp Val Ala Leu Lys Glu Val Ser Val 
            820                 825                 830         


Met Asn Leu Leu Leu Val Val Leu Trp Ala Phe Ala Leu Pro Tyr Pro 
        835                 840                 845             


Arg Phe Arg Pro Met Ala Ser Cys Leu Ser Thr Val Trp Thr Cys Val 
    850                 855                 860                 


Ile Ile Val Cys Lys Met Leu Tyr Gln Leu Lys Val Val Asn Pro Gln 
865                 870                 875                 880 


Glu Tyr Ser Ser Asn Cys Thr Glu Pro Phe Pro Asn Ser Thr Asn Leu 
                885                 890                 895     


Leu Pro Thr Glu Ile Ser Gln Ser Leu Leu Tyr Arg Gly Pro Val Asp 
            900                 905                 910         


Pro Ala Asn Trp Phe Gly Val Arg Lys Gly Phe Pro Asn Leu Gly Tyr 
        915                 920                 925             


Ile Gln Asn His Leu Gln Val Leu Leu Leu Leu Val Phe Glu Ala Ile 
    930                 935                 940                 


Val Tyr Arg Arg Gln Glu His Tyr Arg Arg Gln His Gln Leu Ala Pro 
945                 950                 955                 960 


Leu Pro Ala Gln Ala Val Phe Ala Ser Gly Thr Arg Gln Gln Leu Asp 
                965                 970                 975     


Gln Asp Leu Leu Gly Cys Leu Lys Tyr Phe Ile Asn Phe Phe Phe Tyr 
            980                 985                 990         


Lys Phe Gly Leu Glu Ile Cys Phe  Leu Met Ala Val Asn  Val Ile Gly 
        995                 1000                 1005             


Gln Arg  Met Asn Phe Leu Val  Thr Leu His Gly Cys  Trp Leu Val 
    1010                 1015                 1020             


Ala Ile  Leu Thr Arg Arg His  Arg Gln Ala Ile Ala  Arg Leu Trp 
    1025                 1030                 1035             


Pro Asn  Tyr Cys Leu Phe Leu  Ala Leu Phe Leu Leu  Tyr Gln Tyr 
    1040                 1045                 1050             


Leu Leu  Cys Leu Gly Met Pro  Pro Ala Leu Cys Ile  Asp Tyr Pro 
    1055                 1060                 1065             


Trp Arg  Trp Ser Arg Ala Val  Pro Met Asn Ser Ala  Leu Ile Lys 
    1070                 1075                 1080             


Trp Leu  Tyr Leu Pro Asp Phe  Phe Arg Ala Pro Asn  Ser Thr Asn 
    1085                 1090                 1095             


Leu Ile  Ser Asp Phe Leu Leu  Leu Leu Cys Ala Ser  Gln Gln Trp 
    1100                 1105                 1110             


Gln Val  Phe Ser Ala Glu Arg  Thr Glu Glu Trp Gln  Arg Met Ala 
    1115                 1120                 1125             


Gly Val  Asn Thr Asp Arg Leu  Glu Pro Leu Arg Gly  Glu Pro Asn 
    1130                 1135                 1140             


Pro Val  Pro Asn Phe Ile His  Cys Arg Ser Tyr Leu  Asp Met Leu 
    1145                 1150                 1155             


Lys Val  Ala Val Phe Arg Tyr  Leu Phe Trp Leu Val  Leu Val Val 
    1160                 1165                 1170             


Val Phe  Val Thr Gly Ala Thr  Arg Ile Ser Ile Phe  Gly Leu Gly 
    1175                 1180                 1185             


Tyr Leu  Leu Ala Cys Phe Tyr  Leu Leu Leu Phe Gly  Thr Ala Leu 
    1190                 1195                 1200             


Leu Gln  Arg Asp Thr Arg Ala  Arg Leu Val Leu Trp  Asp Cys Leu 
    1205                 1210                 1215             


Ile Leu  Tyr Asn Val Thr Val  Ile Ile Ser Lys Asn  Met Leu Ser 
    1220                 1225                 1230             


Leu Leu  Ala Cys Val Phe Val  Glu Gln Met Gln Thr  Gly Phe Cys 
    1235                 1240                 1245             


Trp Val  Ile Gln Leu Phe Ser  Leu Val Cys Thr Val  Lys Gly Tyr 
    1250                 1255                 1260             


Tyr Asp  Pro Lys Glu Met Met  Asp Arg Asp Gln Asp  Cys Leu Leu 
    1265                 1270                 1275             


Pro Val  Glu Glu Ala Gly Ile  Ile Trp Asp Ser Val  Cys Phe Phe 
    1280                 1285                 1290             


Phe Leu  Leu Leu Gln Arg Arg  Val Phe Leu Ser His  Tyr Tyr Leu 
    1295                 1300                 1305             


His Val  Arg Ala Asp Leu Gln  Ala Thr Ala Leu Leu  Ala Ser Arg 
    1310                 1315                 1320             


Gly Phe  Ala Leu Tyr Asn Ala  Ala Asn Leu Lys Ser  Ile Asp Phe 
    1325                 1330                 1335             


His Arg  Arg Ile Glu Glu Lys  Ser Leu Ala Gln Leu  Lys Arg Gln 
    1340                 1345                 1350             


Met Glu  Arg Ile Arg Ala Lys  Gln Glu Lys His Arg  Gln Gly Arg 
    1355                 1360                 1365             


Val Asp  Arg Ser Arg Pro Gln  Asp Thr Leu Gly Pro  Lys Asp Pro 
    1370                 1375                 1380             


Gly Leu  Glu Pro Gly Pro Asp  Ser Pro Gly Gly Ser  Ser Pro Pro 
    1385                 1390                 1395             


Arg Arg  Gln Trp Trp Arg Pro  Trp Leu Asp His Ala  Thr Val Ile 
    1400                 1405                 1410             


His Ser  Gly Asp Tyr Phe Leu  Phe Glu Ser Asp Ser  Glu Glu Glu 
    1415                 1420                 1425             


Glu Glu  Ala Val Pro Glu Asp  Pro Arg Pro Ser Ala  Gln Ser Ala 
    1430                 1435                 1440             


Phe Gln  Leu Ala Tyr Gln Ala  Trp Val Thr Asn Ala  Gln Ala Val 
    1445                 1450                 1455             


Leu Arg  Arg Arg Gln Gln Glu  Gln Glu Gln Ala Arg  Gln Glu Gln 
    1460                 1465                 1470             


Ala Gly  Gln Leu Pro Thr Gly  Gly Gly Pro Ser Gln  Glu Val Glu 
    1475                 1480                 1485             


Pro Ala  Glu Gly Pro Glu Glu  Ala Ala Ala Gly Arg  Ser His Val 
    1490                 1495                 1500             


Val Gln  Arg Val Leu Ser Thr  Ala Gln Phe Leu Trp  Met Leu Gly 
    1505                 1510                 1515             


Gln Ala  Leu Val Asp Glu Leu  Thr Arg Trp Leu Gln  Glu Phe Thr 
    1520                 1525                 1530             


Arg His  His Gly Thr Met Ser  Asp Val Leu Arg Ala  Glu Arg Tyr 
    1535                 1540                 1545             


Leu Leu  Thr Gln Glu Leu Leu  Gln Gly Gly Glu Val  His Arg Gly 
    1550                 1555                 1560             


Val Leu  Asp Gln Leu Tyr Thr  Ser Gln Ala Glu Ala  Thr Leu Pro 
    1565                 1570                 1575             


Gly Pro  Thr Glu Ala Pro Asn  Ala Pro Ser Thr Val  Ser Ser Gly 
    1580                 1585                 1590             


Leu Gly  Ala Glu Glu Pro Leu  Ser Ser Met Thr Asp  Asp Met Gly 
    1595                 1600                 1605             


Ser Pro  Leu Ser Thr Gly Tyr  His Thr Arg Ser Gly  Ser Glu Glu 
    1610                 1615                 1620             


Ala Val  Thr Asp Pro Gly Glu  Arg Glu Ala Gly Ala  Ser Leu Tyr 
    1625                 1630                 1635             


Gln Gly  Leu Met Arg Thr Ala  Ser Glu Leu Leu Leu  Asp Arg Arg 
    1640                 1645                 1650             


Leu Arg  Ile Pro Glu Leu Glu  Glu Ala Glu Leu Phe  Ala Glu Gly 
    1655                 1660                 1665             


Gln Gly  Arg Ala Leu Arg Leu  Leu Arg Ala Val Tyr  Gln Cys Val 
    1670                 1675                 1680             


Ala Ala  His Ser Glu Leu Leu  Cys Tyr Phe Ile Ile  Ile Leu Asn 
    1685                 1690                 1695             


His Met  Val Thr Ala Ser Ala  Gly Ser Leu Val Leu  Pro Val Leu 
    1700                 1705                 1710             


Val Phe  Leu Trp Ala Met Leu  Ser Ile Pro Arg Pro  Ser Lys Arg 
    1715                 1720                 1725             


Phe Trp  Met Thr Ala Ile Val  Phe Thr Glu Ile Ala  Val Val Val 
    1730                 1735                 1740             


Lys Tyr  Leu Phe Gln Phe Gly  Phe Phe Pro Trp Asn  Ser His Val 
    1745                 1750                 1755             


Val Leu  Arg Arg Tyr Glu Asn  Lys Pro Tyr Phe Pro  Pro Arg Ile 
    1760                 1765                 1770             


Leu Gly  Leu Glu Lys Thr Asp  Gly Tyr Ile Lys Tyr  Asp Leu Val 
    1775                 1780                 1785             


Gln Leu  Met Ala Leu Phe Phe  His Arg Ser Gln Leu  Leu Cys Tyr 
    1790                 1795                 1800             


Gly Leu  Trp Asp His Glu Glu  Asp Ser Pro Ser Lys  Glu His Asp 
    1805                 1810                 1815             


Lys Ser  Gly Glu Glu Glu Gln  Gly Ala Glu Glu Gly  Pro Gly Val 
    1820                 1825                 1830             


Pro Ala  Ala Thr Thr Glu Asp  His Ile Gln Val Glu  Ala Arg Val 
    1835                 1840                 1845             


Gly Pro  Thr Asp Gly Thr Pro  Glu Pro Gln Val Glu  Leu Arg Pro 
    1850                 1855                 1860             


Arg Asp  Thr Arg Arg Ile Ser  Leu Arg Phe Arg Arg  Arg Lys Lys 
    1865                 1870                 1875             


Glu Gly  Pro Ala Arg Lys Gly  Ala Ala Ala Ile Glu  Ala Glu Asp 
    1880                 1885                 1890             


Arg Glu  Glu Glu Glu Gly Glu  Glu Glu Lys Glu Ala  Pro Thr Gly 
    1895                 1900                 1905             


Arg Glu  Lys Arg Pro Ser Arg  Ser Gly Gly Arg Val  Arg Ala Ala 
    1910                 1915                 1920             


Gly Arg  Arg Leu Gln Gly Phe  Cys Leu Ser Leu Ala  Gln Gly Thr 
    1925                 1930                 1935             


Tyr Arg  Pro Leu Arg Arg Phe  Phe His Asp Ile Leu  His Thr Lys 
    1940                 1945                 1950             


Tyr Arg  Ala Ala Thr Asp Val  Tyr Ala Leu Met Phe  Leu Ala Asp 
    1955                 1960                 1965             


Val Val  Asp Phe Ile Ile Ile  Ile Phe Gly Phe Trp  Ala Phe Gly 
    1970                 1975                 1980             


Lys His  Ser Ala Ala Thr Asp  Ile Thr Ser Ser Leu  Ser Asp Asp 
    1985                 1990                 1995             


Gln Val  Pro Glu Ala Phe Leu  Val Met Leu Leu Ile  Gln Phe Ser 
    2000                 2005                 2010             


Thr Met  Val Val Asp Arg Ala  Leu Tyr Leu Arg Lys  Thr Val Leu 
    2015                 2020                 2025             


Gly Lys  Leu Ala Phe Gln Val  Ala Leu Val Leu Ala  Ile His Leu 
    2030                 2035                 2040             


Trp Met  Phe Phe Ile Leu Pro  Ala Val Thr Glu Arg  Met Phe Asn 
    2045                 2050                 2055             


Gln Asn  Val Val Ala Gln Leu  Trp Tyr Phe Val Lys  Cys Ile Tyr 
    2060                 2065                 2070             


Phe Ala  Leu Ser Ala Tyr Gln  Ile Arg Cys Gly Tyr  Pro Thr Arg 
    2075                 2080                 2085             


Ile Leu  Gly Asn Phe Leu Thr  Lys Lys Tyr Asn His  Leu Asn Leu 
    2090                 2095                 2100             


Phe Leu  Phe Gln Gly Phe Arg  Leu Val Pro Phe Leu  Val Glu Leu 
    2105                 2110                 2115             


Arg Ala  Val Met Asp Trp Val  Trp Thr Asp Thr Thr  Leu Ser Leu 
    2120                 2125                 2130             


Ser Ser  Trp Met Cys Val Glu  Asp Ile Tyr Ala Asn  Ile Phe Ile 
    2135                 2140                 2145             


Ile Lys  Cys Ser Arg Glu Thr  Glu Lys Lys Tyr Pro  Gln Pro Lys 
    2150                 2155                 2160             


Gly Gln  Lys Lys Lys Lys Ile  Val Lys Tyr Gly Met  Gly Gly Leu 
    2165                 2170                 2175             


Ile Ile  Leu Phe Leu Ile Ala  Ile Ile Trp Phe Pro  Leu Leu Phe 
    2180                 2185                 2190             


Met Ser  Leu Val Arg Ser Val  Val Gly Val Val Asn  Gln Pro Ile 
    2195                 2200                 2205             


Asp Val  Thr Val Thr Leu Lys  Leu Gly Gly Tyr Glu  Pro Leu Phe 
    2210                 2215                 2220             


Thr Met  Ser Ala Gln Gln Pro  Ser Ile Ile Pro Phe  Thr Ala Gln 
    2225                 2230                 2235             


Ala Tyr  Glu Glu Leu Ser Arg  Gln Phe Asp Pro Gln  Pro Leu Ala 
    2240                 2245                 2250             


Met Gln  Phe Ile Ser Gln Tyr  Ser Pro Glu Asp Ile  Val Thr Ala 
    2255                 2260                 2265             


Gln Ile  Glu Gly Ser Ser Gly  Ala Leu Trp Arg Ile  Ser Pro Pro 
    2270                 2275                 2280             


Ser Arg  Ala Gln Met Lys Arg  Glu Leu Tyr Asn Gly  Thr Ala Asp 
    2285                 2290                 2295             


Ile Thr  Leu Arg Phe Thr Trp  Asn Phe Gln Arg Asp  Leu Ala Lys 
    2300                 2305                 2310             


Gly Gly  Thr Val Glu Tyr Ala  Asn Glu Lys His Met  Leu Ala Leu 
    2315                 2320                 2325             


Ala Pro  Asn Ser Thr Ala Arg  Arg Gln Leu Ala Ser  Leu Leu Glu 
    2330                 2335                 2340             


Gly Thr  Ser Asp Gln Ser Val  Val Ile Pro Asn Leu  Phe Pro Lys 
    2345                 2350                 2355             


Tyr Ile  Arg Ala Pro Asn Gly  Pro Glu Ala Asn Pro  Val Lys Gln 
    2360                 2365                 2370             


Leu Gln  Pro Asn Glu Glu Ala  Asp Tyr Leu Gly Val  Arg Ile Gln 
    2375                 2380                 2385             


Leu Arg  Arg Glu Gln Gly Ala  Gly Ala Thr Gly Phe  Leu Glu Trp 
    2390                 2395                 2400             


Trp Val  Ile Glu Leu Gln Glu  Cys Arg Thr Asp Cys  Asn Leu Leu 
    2405                 2410                 2415             


Pro Met  Val Ile Phe Ser Asp  Lys Val Ser Pro Pro  Ser Leu Gly 
    2420                 2425                 2430             


Phe Leu  Ala Gly Tyr Gly Ile  Met Gly Leu Tyr Val  Ser Ile Val 
    2435                 2440                 2445             


Leu Val  Ile Gly Lys Phe Val  Arg Gly Phe Phe Ser  Glu Ile Ser 
    2450                 2455                 2460             


His Ser  Ile Met Phe Glu Glu  Leu Pro Cys Val Asp  Arg Ile Leu 
    2465                 2470                 2475             


Lys Leu  Cys Gln Asp Ile Phe  Leu Val Arg Glu Thr  Arg Glu Leu 
    2480                 2485                 2490             


Glu Leu  Glu Glu Glu Leu Tyr  Ala Lys Leu Ile Phe  Leu Tyr Arg 
    2495                 2500                 2505             


Ser Pro  Glu Thr Met Ile Lys  Trp Thr Arg Glu Lys  Glu 
    2510                 2515                 2520     


<210>  19
<211>  8259
<212>  DNA
<213>  Homo sapiens

<400>  19
atggcctcag aagtggtgtg cgggctcatc ttcaggctgc tgctgcccat ctgcctggca       60

gtagcatgtg cattccgata caatgggctc tcctttgtct accttatcta cctcttgctc      120

attcctctgt tctcagaacc aacaaaaacg acgatgcaag gacatacggg acggttatta      180

aagtctctgt gcttcatcag tctttccttc ctgttgctgc acatcatttt ccacatcacg      240

ttggtgagcc ttgaagctca acatcgtatt gcacctggct acaactgctc aacatgggaa      300

aagacattcc ggcagatcgg ctttgaaagc ttaaagggag ctgatgctgg caatgggatc      360

agagtgtttg tacctgacat cgggatgttc attgctagtc tgaccatctg gctcctctgt      420

agaaacattg ttcagaaacc tgtgacagac gaagcagcac agagtaaccc ggagtttgaa      480

aatgaagaat tggctgaagg agaaaaaatt gattcagaag aggcactgat ctatgaagag      540

gatttcaatg gaggagatgg tgttgaaggc gagttggaag aaagcacgaa gttaaaaatg      600

ttccgcaggc ttgcctctgt ggcctctaag ctcaaggagt tcattggcaa catgatcacc      660

actgctggga aagtcgttgt taccatctta ctgggctcct cgggcatgat gttgccgtct      720

ttgacatcat ctgtgtattt ttttgtattt ttgggtctgt gcacctggtg gtcctggtgc      780

cggacgttcg acccattgct gttcagctgt ctctgtgttc tgctggctat tttcactgct      840

ggacatttga ttggacttta tttataccag ttccaattct ttcaagaggc agttccaccc      900

aatgactact atgcaaggtt gtttggtatc aagtcagtaa ttcaaacgga ctgttcaagt      960

acttggaaga tcatagtgaa cccggacctg tcgtggtacc accacgccaa ccctatcctc     1020

ctgctggtga tgtactacac tctggccact ctgatccgca tctggctgca agagcccctt     1080

gtgcaggatg aggggaccaa agaagaggac aaagccctgg cttgtagccc catccaaata     1140

acagcgggga ggaggcggag cctgtggtac gcaacccatt accccactga tgagagaaaa     1200

cttttatcca tgacccagga tgactacaaa ccatctgatg gcctgctggt gactgtgaac     1260

ggcaaccccg tggattacca caccatccac ccaagcctgc ccatggagaa cggccctggc     1320

aaagccgacc tctactccac ccctcagtac cggtgggagc cctctgatga atcctcagaa     1380

aagcgagagg aggaagagga agagaaagaa gaatttgaag aagaaaggag ccgtgaggaa     1440

aaaagaagta tcaaagttca tgccatggtc tccgtattcc aatttattat gaaacaaagt     1500

tacatctgtg ccctcatagc tatgatggcc tggagcatca cctatcacag ctggctgacc     1560

ttcgtgctgc tgatctggtc gtgcactctt tggatgattc gcaacagaag aaaatatgcc     1620

atgatcagct ctcccttcat ggtggtttat ggaaacctat tgttgatatt acagtatata     1680

tggagttttg aacttcctga aattaaaaaa gttccaggat ttttagaaaa gaaagagcca     1740

ggagaacttg cttccaaaat ccttttcacc attacttttt ggctactgct gaggcagcac     1800

ctcacagagc aaaaagctct gcaagaaaag gaagctcttt tatcggaagt caaaattggc     1860

agtcaggaaa atgaagaaaa agatgaggaa cttcaagata tacaagtgga aggagagccc     1920

aaagaggagg aagaagagga agcgaaggaa gagaagcaag agagaaagaa ggtagagcaa     1980

gaggaagctg aagaagaaga tgagcaggac atcatgaaag tcctgggcaa tctggtggtg     2040

gccatgttca tcaagtactg gatctacgtc tgcggaggca tgttcttctt cgtcagcttc     2100

gagggtaaaa tcgtaatgta caaaatcatc tacatggtgc tgttcctgtt ctgtgtggcc     2160

ctataccagg tgcactatga atggtggagg aaaattctaa aatatttttg gatgtcagtg     2220

gttatttaca ctatgctggt gcttatcttt atatacacat atcagtttga gaacttccca     2280

ggcctgtggc aaaatatgac tggactgaaa aaagaaaagc ttgaggatct tggcttaaag     2340

cagtttactg tggctgaact attcactcgc atattcatcc caacctcctt tctgctggtg     2400

tgcattttac acctgcacta cttccatgac cggttccttg aactcacaga cctcaagtcc     2460

attcccagca aagaagacaa caccatctac agactggccc acccggaagg aagcctcccg     2520

gacctcacca tgatgcatct gactgccagc ctggagaagc cggaggtgag gaagttggct     2580

gagcctgggg aggagaagct tgagggctac tctgaaaaag cccagaaggg tgatcttggg     2640

aaagacagcg aggagtcaga ggaggacgga gaggaagagg aggaatccga ggaggaggaa     2700

gaaacatcag acttaaggaa caaatggcac ctggtgattg accgcctcac tgtgctcttc     2760

ttaaaattcc tggagtattt tcacaagctg caggtgttca tgtggtggat tttggagttg     2820

cacatcatca aaatcgtttc ctcttacatt atctgggttt ctgtgaaaga ggtgtctctg     2880

ttcaactatg tatttttgat ttcttgggct tttgctctgc cgtacgccaa gctgcgccgt     2940

ctggcttcaa gtgtctgcac agtctggacg tgtgtgatca tcgtctgcaa aatgttgtac     3000

cagctccaaa ccattaagcc tgagaacttc tctgttaact gttccttgcc aaatgaaaat     3060

caaacaaaca tcccctttaa tgagttgaac aagtctctgc tctacagcgc tcctatcgat     3120

cctacagagt gggtcggcct gcggaagtct tcgcctctgc tagtctacct gaggaataac     3180

ctcctgatgc tggctatcct ggcctttgaa gtcaccattt accgccatca ggaatactat     3240

cgaggtcgaa ataacctgac ggcccctgtg tctagaacta tctttcatga cattacaaga     3300

ctacatctag atgatggact tattaattgt gccaaatatt tcattaatta cttcttttac     3360

aagtttggtc tggagacctg tttcctaatg tcagttaacg tcattggcca gcgaatggat     3420

ttctatgcca tgatccacgc ctgctggctg atcgctgtct tatatagacg cagaaggaaa     3480

gccatcgcag agatctggcc caagtactgc tgcttcctgg catgcatcat caccttccag     3540

tatttcatct gcattggcat cccacctgct ccttgccgag attacccgtg gagattcaag     3600

ggtgccagct tcaatgacaa catcataaag tggctgtact tcccagattt cattgtgcgg     3660

cccaaccctg tgtttctcgt ctatgacttc atgctgcttc tgtgtgcctc cttacaacgg     3720

cagatttttg aggatgagaa caaggctgca gtgcgaatca tggcaggtga caatgtcgag     3780

atctgcatga accttgatgc ggcctccttc agccaacata accctgtgcc agattttatt     3840

cactgcagat cttacttaga catgtccaaa gtgatcatct tcagctacct cttctggttt     3900

gtgctcacca tcatcttcat cactgggacc accaggatca gcatcttttg catggggtac     3960

ctggtggcct gtttctactt cctgctcttt gggggcgatt tgctgttgaa acccatcaag     4020

agcatcctgc gctactggga ctggctgatc gcatacaacg tttttgtgat tacgatgaaa     4080

aatatcctgt caataggagc atgtggatac attggaacat tggtgcacaa tagttgttgg     4140

ttgatccagg ctttcagcct ggcctgcaca gtcaaaggct atcaaatgcc tgctgctaat     4200

tcaccctgta cacttcccag tggggaagca ggaatcattt gggacagcat atgttttgcc     4260

ttcctcctgc tgcaaagaag agttttcatg agttattatt ttctacatgt tgtggctgat     4320

ataaaagctt cccagattct ggcatcaaga ggagctgaac ttttccaggc cacaattgta     4380

aaagctgtaa aggcaagaat tgaggaagag aagaagtcca tggaccagct gaagcgacag     4440

atggatcgca tcaaggccag gcaacagaaa tataaaaagg gtaaggagag gatgctgagc     4500

ttgacccagg agccagggga aggccaggac atgcaaaaac tctctgaaga ggatgatgaa     4560

agagaagcag acaaacagaa agccaagggc aaaaaaaagc agtggtggcg gccttgggtt     4620

gatcatgctt ccatggtcag gagtggagat tattatttgt ttgaaacgga tagtgaagag     4680

gaggaagagg aagaattaaa gaaggaagat gaagaacctc cacgaaggtc agcattccag     4740

tttgtttatc aagcctggat tactgatcct aaaacagcac tccgacaaag acacaaagag     4800

aaaaaaaggt ctgcaagaga agaacggaaa cgaaggcgga aaggatccaa ggagggtcct     4860

gtggaatggg aagaccggga ggatgaacca atcaaaaaga aatccgatgg accagataat     4920

atcatcaaga ggatatttaa tattttgaaa tttacctggg tcctatttct ggcaacagtg     4980

gacagtttca ctacttggct taactccatt tcaagggagc atattgatat atctacagtt     5040

ctgagaattg aacgatgcat gctgaccaga gaaattaaga agggcaatgt tccaactcgg     5100

gagagcatcc acatgtacta tcagaaccac atcatgaacc tttccagaga gtcgggactg     5160

gacaccattg acgagcatcc cggagctgct tcaggtgcac agacagccca caggatggat     5220

agtttagatt cacatgacag tatctccagc gagcccacgc agtgtaccat gctgtactca     5280

cgccagggga ccactgagac catcgaggag gtggaggctg agcaggagga ggaggcaggg     5340

agcacggcgc ctgagcccag ggaggccaag gagtacgagg ccactgggta cgatgtggga     5400

gccatgggtg ccgaggaggc cagcctcacc ccagaggaag agctgacaca gttctccacc     5460

ttggacgggg atgtggaggc cccaccctcc tacagcaagg ctgtgagctt cgagcatctg     5520

tccttcggct cgcaggacga ctctgcaggc aagaaccgta tggcagtcag cccggacgac     5580

agccgcaccg acaagctggg gtccagcatc ttacctcccc tgacccatga gctgacggcc     5640

agcgagctgc tgctgaaaaa gatgtttcac gacgatgagc ttgaagagtc agagaaattc     5700

tacgtggggc agccccgatt tctgctgctc ttctatgcca tgtacaatac cctggtggcc     5760

cgctcggaga tggtgtgcta cttcgtgatc atcctcaacc acatggtctc tgcctccatg     5820

atcacgctcc tgcttcccat cctcatcttc ctctgggcca tgttgtccgt ccccaggccc     5880

agccgccggt tctggatgat ggccatcgtc tatactgagg tggcaattgt agtcaagtat     5940

ttcttccaat ttgggttctt tccctggaat aagaatgtgg aggtgaacaa agataaaccg     6000

tatcaccccc caaacatcat aggagtggaa aagaaggaag gttatgttct ctatgacctc     6060

atccagctcc tggctctgtt ctttcatcga tcaattttga agtgccatgg cttatgggat     6120

gaagatgaca tgactgaaag tggcatggcc agggaggaat cagatgatga gctctccctc     6180

ggtcatggca ggagggactc ctccgattct ctcaagtcca tcaacctggc cgcgtctgtg     6240

gagtcagtgc atgtgacctt cccggagcag cagacagctg tccggaggaa gcgctccggc     6300

agcagctccg agccatccca gagatccagc ttttcttcaa acagatccca aagaggcagc     6360

acaagcaccc gaaacagcag tcaaaaagga agcagtgttt tgagtattaa gcaaaaaggc     6420

aaaagggaac tttatatgga aaagcttcaa gaacatttaa tcaaagcaaa agcctttacc     6480

ataaagaaga cgctggagat ctatgtgccc atcaaacagt tcttttacaa cctcatccac     6540

ccggagtata gcgccgtgac tgacgtgtat gtactcatgt tcctggctga cactgtggac     6600

ttcatcatca ttgtcttcgg cttttgggcc tttgggaaac actcagcagc tgcagacatc     6660

acctcttcac tgtcagagga ccaggtcccg gggccgtttt tggtgatggt cctcattcag     6720

tttggaacca tggtggtgga ccgagccctc tacctcagga agactgtact gggaaaggtc     6780

atcttccagg tcattcttgt gttcggaatt cacttctgga tgttcttcat cttacctggt     6840

gtgactgaga ggaaattcag ccagaacctg gttgcccagc tttggtactt tgtgaaatgt     6900

gtttacttcg ggttgtctgc ttaccagatc cgttgtggct acccaacgcg agtcctgggg     6960

aacttcctca ccaagagcta caattacgtc aacctcttct tattccaagg gtttcgcctc     7020

gtgccctttt tgactgagct gagggcagtg atggactggg tgtggacgga cacaactttg     7080

agcctgtcca gctggatctg tgtggaggac atctatgctc acatattcat cctgaagtgt     7140

tggcgggagt cggagaagag ataccctcag ccacggggcc agaagaagaa gaaagtggtg     7200

aagtatggca tgggaggaat gatcatcgtc ctgctcatct gcattgtctg gtttcctctt     7260

ctcttcatgt ctttgatcaa atctgtggct ggggtcatca accagcccct ggacgtctcc     7320

gtcacaatta ccctgggagg gtatcagcct attttcacaa tgagtgccca acaaagccag     7380

ttgaaagtta tggaccagca gagctttaac aaatttatac aagctttttc tagggacacc     7440

ggtgctatgc aatttctgga aaattatgaa aaagaagaca taacagtagc agaactggaa     7500

ggaaactcaa attctttgtg gaccatcagc ccacccagta agcagaaaat gatacacgaa     7560

ctcctggacc ccaatagtag cttctctgtt gttttttcat ggagtattca gagaaactta     7620

agtctgggtg caaaatcgga aatagcaaca gataagcttt cttttcctct taaaaatatt     7680

actcgaaaga atatcgctaa aatgatagca ggcaacagca cagaaagttc aaaaacacca     7740

gtgaccatag aaaagattta tccatattat gtgaaagcac ctagtgattc taactcaaaa     7800

cctataaagc aacttttatc tgaaaataat ttcatggata ttaccatcat tttgtccaga     7860

gacaatacaa ctaaatataa cagtgagtgg tgggttctca acctgactgg aaacagaata     7920

tacaatccga actctcaggc cctggaactg gtggtcttca atgacaaagt cagtccccca     7980

agtctggggt tcctggctgg ctatggtatt atgggattat atgcttcagt tgtccttgtg     8040

attgggaaat ttgtccgtga attcttcagt gggatttctc actccatcat gtttgaagag     8100

cttccaaatg tggatcgaat tttgaagttg tgcacagata tttttttagt tcgagagaca     8160

ggagaactgg agctagaaga agatctctat gccaaattaa tattcctata tcgctcacca     8220

gagacaatga tcaaatggac tagagaaaaa acaaattga                            8259


<210>  20
<211>  2752
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Ser Glu Val Val Cys Gly Leu Ile Phe Arg Leu Leu Leu Pro 
1               5                   10                  15      


Ile Cys Leu Ala Val Ala Cys Ala Phe Arg Tyr Asn Gly Leu Ser Phe 
            20                  25                  30          


Val Tyr Leu Ile Tyr Leu Leu Leu Ile Pro Leu Phe Ser Glu Pro Thr 
        35                  40                  45              


Lys Thr Thr Met Gln Gly His Thr Gly Arg Leu Leu Lys Ser Leu Cys 
    50                  55                  60                  


Phe Ile Ser Leu Ser Phe Leu Leu Leu His Ile Ile Phe His Ile Thr 
65                  70                  75                  80  


Leu Val Ser Leu Glu Ala Gln His Arg Ile Ala Pro Gly Tyr Asn Cys 
                85                  90                  95      


Ser Thr Trp Glu Lys Thr Phe Arg Gln Ile Gly Phe Glu Ser Leu Lys 
            100                 105                 110         


Gly Ala Asp Ala Gly Asn Gly Ile Arg Val Phe Val Pro Asp Ile Gly 
        115                 120                 125             


Met Phe Ile Ala Ser Leu Thr Ile Trp Leu Leu Cys Arg Asn Ile Val 
    130                 135                 140                 


Gln Lys Pro Val Thr Asp Glu Ala Ala Gln Ser Asn Pro Glu Phe Glu 
145                 150                 155                 160 


Asn Glu Glu Leu Ala Glu Gly Glu Lys Ile Asp Ser Glu Glu Ala Leu 
                165                 170                 175     


Ile Tyr Glu Glu Asp Phe Asn Gly Gly Asp Gly Val Glu Gly Glu Leu 
            180                 185                 190         


Glu Glu Ser Thr Lys Leu Lys Met Phe Arg Arg Leu Ala Ser Val Ala 
        195                 200                 205             


Ser Lys Leu Lys Glu Phe Ile Gly Asn Met Ile Thr Thr Ala Gly Lys 
    210                 215                 220                 


Val Val Val Thr Ile Leu Leu Gly Ser Ser Gly Met Met Leu Pro Ser 
225                 230                 235                 240 


Leu Thr Ser Ser Val Tyr Phe Phe Val Phe Leu Gly Leu Cys Thr Trp 
                245                 250                 255     


Trp Ser Trp Cys Arg Thr Phe Asp Pro Leu Leu Phe Ser Cys Leu Cys 
            260                 265                 270         


Val Leu Leu Ala Ile Phe Thr Ala Gly His Leu Ile Gly Leu Tyr Leu 
        275                 280                 285             


Tyr Gln Phe Gln Phe Phe Gln Glu Ala Val Pro Pro Asn Asp Tyr Tyr 
    290                 295                 300                 


Ala Arg Leu Phe Gly Ile Lys Ser Val Ile Gln Thr Asp Cys Ser Ser 
305                 310                 315                 320 


Thr Trp Lys Ile Ile Val Asn Pro Asp Leu Ser Trp Tyr His His Ala 
                325                 330                 335     


Asn Pro Ile Leu Leu Leu Val Met Tyr Tyr Thr Leu Ala Thr Leu Ile 
            340                 345                 350         


Arg Ile Trp Leu Gln Glu Pro Leu Val Gln Asp Glu Gly Thr Lys Glu 
        355                 360                 365             


Glu Asp Lys Ala Leu Ala Cys Ser Pro Ile Gln Ile Thr Ala Gly Arg 
    370                 375                 380                 


Arg Arg Ser Leu Trp Tyr Ala Thr His Tyr Pro Thr Asp Glu Arg Lys 
385                 390                 395                 400 


Leu Leu Ser Met Thr Gln Asp Asp Tyr Lys Pro Ser Asp Gly Leu Leu 
                405                 410                 415     


Val Thr Val Asn Gly Asn Pro Val Asp Tyr His Thr Ile His Pro Ser 
            420                 425                 430         


Leu Pro Met Glu Asn Gly Pro Gly Lys Ala Asp Leu Tyr Ser Thr Pro 
        435                 440                 445             


Gln Tyr Arg Trp Glu Pro Ser Asp Glu Ser Ser Glu Lys Arg Glu Glu 
    450                 455                 460                 


Glu Glu Glu Glu Lys Glu Glu Phe Glu Glu Glu Arg Ser Arg Glu Glu 
465                 470                 475                 480 


Lys Arg Ser Ile Lys Val His Ala Met Val Ser Val Phe Gln Phe Ile 
                485                 490                 495     


Met Lys Gln Ser Tyr Ile Cys Ala Leu Ile Ala Met Met Ala Trp Ser 
            500                 505                 510         


Ile Thr Tyr His Ser Trp Leu Thr Phe Val Leu Leu Ile Trp Ser Cys 
        515                 520                 525             


Thr Leu Trp Met Ile Arg Asn Arg Arg Lys Tyr Ala Met Ile Ser Ser 
    530                 535                 540                 


Pro Phe Met Val Val Tyr Gly Asn Leu Leu Leu Ile Leu Gln Tyr Ile 
545                 550                 555                 560 


Trp Ser Phe Glu Leu Pro Glu Ile Lys Lys Val Pro Gly Phe Leu Glu 
                565                 570                 575     


Lys Lys Glu Pro Gly Glu Leu Ala Ser Lys Ile Leu Phe Thr Ile Thr 
            580                 585                 590         


Phe Trp Leu Leu Leu Arg Gln His Leu Thr Glu Gln Lys Ala Leu Gln 
        595                 600                 605             


Glu Lys Glu Ala Leu Leu Ser Glu Val Lys Ile Gly Ser Gln Glu Asn 
    610                 615                 620                 


Glu Glu Lys Asp Glu Glu Leu Gln Asp Ile Gln Val Glu Gly Glu Pro 
625                 630                 635                 640 


Lys Glu Glu Glu Glu Glu Glu Ala Lys Glu Glu Lys Gln Glu Arg Lys 
                645                 650                 655     


Lys Val Glu Gln Glu Glu Ala Glu Glu Glu Asp Glu Gln Asp Ile Met 
            660                 665                 670         


Lys Val Leu Gly Asn Leu Val Val Ala Met Phe Ile Lys Tyr Trp Ile 
        675                 680                 685             


Tyr Val Cys Gly Gly Met Phe Phe Phe Val Ser Phe Glu Gly Lys Ile 
    690                 695                 700                 


Val Met Tyr Lys Ile Ile Tyr Met Val Leu Phe Leu Phe Cys Val Ala 
705                 710                 715                 720 


Leu Tyr Gln Val His Tyr Glu Trp Trp Arg Lys Ile Leu Lys Tyr Phe 
                725                 730                 735     


Trp Met Ser Val Val Ile Tyr Thr Met Leu Val Leu Ile Phe Ile Tyr 
            740                 745                 750         


Thr Tyr Gln Phe Glu Asn Phe Pro Gly Leu Trp Gln Asn Met Thr Gly 
        755                 760                 765             


Leu Lys Lys Glu Lys Leu Glu Asp Leu Gly Leu Lys Gln Phe Thr Val 
    770                 775                 780                 


Ala Glu Leu Phe Thr Arg Ile Phe Ile Pro Thr Ser Phe Leu Leu Val 
785                 790                 795                 800 


Cys Ile Leu His Leu His Tyr Phe His Asp Arg Phe Leu Glu Leu Thr 
                805                 810                 815     


Asp Leu Lys Ser Ile Pro Ser Lys Glu Asp Asn Thr Ile Tyr Arg Leu 
            820                 825                 830         


Ala His Pro Glu Gly Ser Leu Pro Asp Leu Thr Met Met His Leu Thr 
        835                 840                 845             


Ala Ser Leu Glu Lys Pro Glu Val Arg Lys Leu Ala Glu Pro Gly Glu 
    850                 855                 860                 


Glu Lys Leu Glu Gly Tyr Ser Glu Lys Ala Gln Lys Gly Asp Leu Gly 
865                 870                 875                 880 


Lys Asp Ser Glu Glu Ser Glu Glu Asp Gly Glu Glu Glu Glu Glu Ser 
                885                 890                 895     


Glu Glu Glu Glu Glu Thr Ser Asp Leu Arg Asn Lys Trp His Leu Val 
            900                 905                 910         


Ile Asp Arg Leu Thr Val Leu Phe Leu Lys Phe Leu Glu Tyr Phe His 
        915                 920                 925             


Lys Leu Gln Val Phe Met Trp Trp Ile Leu Glu Leu His Ile Ile Lys 
    930                 935                 940                 


Ile Val Ser Ser Tyr Ile Ile Trp Val Ser Val Lys Glu Val Ser Leu 
945                 950                 955                 960 


Phe Asn Tyr Val Phe Leu Ile Ser Trp Ala Phe Ala Leu Pro Tyr Ala 
                965                 970                 975     


Lys Leu Arg Arg Leu Ala Ser Ser Val Cys Thr Val Trp Thr Cys Val 
            980                 985                 990         


Ile Ile Val Cys Lys Met Leu Tyr  Gln Leu Gln Thr Ile  Lys Pro Glu 
        995                 1000                 1005             


Asn Phe  Ser Val Asn Cys Ser  Leu Pro Asn Glu Asn  Gln Thr Asn 
    1010                 1015                 1020             


Ile Pro  Phe Asn Glu Leu Asn  Lys Ser Leu Leu Tyr  Ser Ala Pro 
    1025                 1030                 1035             


Ile Asp  Pro Thr Glu Trp Val  Gly Leu Arg Lys Ser  Ser Pro Leu 
    1040                 1045                 1050             


Leu Val  Tyr Leu Arg Asn Asn  Leu Leu Met Leu Ala  Ile Leu Ala 
    1055                 1060                 1065             


Phe Glu  Val Thr Ile Tyr Arg  His Gln Glu Tyr Tyr  Arg Gly Arg 
    1070                 1075                 1080             


Asn Asn  Leu Thr Ala Pro Val  Ser Arg Thr Ile Phe  His Asp Ile 
    1085                 1090                 1095             


Thr Arg  Leu His Leu Asp Asp  Gly Leu Ile Asn Cys  Ala Lys Tyr 
    1100                 1105                 1110             


Phe Ile  Asn Tyr Phe Phe Tyr  Lys Phe Gly Leu Glu  Thr Cys Phe 
    1115                 1120                 1125             


Leu Met  Ser Val Asn Val Ile  Gly Gln Arg Met Asp  Phe Tyr Ala 
    1130                 1135                 1140             


Met Ile  His Ala Cys Trp Leu  Ile Ala Val Leu Tyr  Arg Arg Arg 
    1145                 1150                 1155             


Arg Lys  Ala Ile Ala Glu Ile  Trp Pro Lys Tyr Cys  Cys Phe Leu 
    1160                 1165                 1170             


Ala Cys  Ile Ile Thr Phe Gln  Tyr Phe Ile Cys Ile  Gly Ile Pro 
    1175                 1180                 1185             


Pro Ala  Pro Cys Arg Asp Tyr  Pro Trp Arg Phe Lys  Gly Ala Ser 
    1190                 1195                 1200             


Phe Asn  Asp Asn Ile Ile Lys  Trp Leu Tyr Phe Pro  Asp Phe Ile 
    1205                 1210                 1215             


Val Arg  Pro Asn Pro Val Phe  Leu Val Tyr Asp Phe  Met Leu Leu 
    1220                 1225                 1230             


Leu Cys  Ala Ser Leu Gln Arg  Gln Ile Phe Glu Asp  Glu Asn Lys 
    1235                 1240                 1245             


Ala Ala  Val Arg Ile Met Ala  Gly Asp Asn Val Glu  Ile Cys Met 
    1250                 1255                 1260             


Asn Leu  Asp Ala Ala Ser Phe  Ser Gln His Asn Pro  Val Pro Asp 
    1265                 1270                 1275             


Phe Ile  His Cys Arg Ser Tyr  Leu Asp Met Ser Lys  Val Ile Ile 
    1280                 1285                 1290             


Phe Ser  Tyr Leu Phe Trp Phe  Val Leu Thr Ile Ile  Phe Ile Thr 
    1295                 1300                 1305             


Gly Thr  Thr Arg Ile Ser Ile  Phe Cys Met Gly Tyr  Leu Val Ala 
    1310                 1315                 1320             


Cys Phe  Tyr Phe Leu Leu Phe  Gly Gly Asp Leu Leu  Leu Lys Pro 
    1325                 1330                 1335             


Ile Lys  Ser Ile Leu Arg Tyr  Trp Asp Trp Leu Ile  Ala Tyr Asn 
    1340                 1345                 1350             


Val Phe  Val Ile Thr Met Lys  Asn Ile Leu Ser Ile  Gly Ala Cys 
    1355                 1360                 1365             


Gly Tyr  Ile Gly Thr Leu Val  His Asn Ser Cys Trp  Leu Ile Gln 
    1370                 1375                 1380             


Ala Phe  Ser Leu Ala Cys Thr  Val Lys Gly Tyr Gln  Met Pro Ala 
    1385                 1390                 1395             


Ala Asn  Ser Pro Cys Thr Leu  Pro Ser Gly Glu Ala  Gly Ile Ile 
    1400                 1405                 1410             


Trp Asp  Ser Ile Cys Phe Ala  Phe Leu Leu Leu Gln  Arg Arg Val 
    1415                 1420                 1425             


Phe Met  Ser Tyr Tyr Phe Leu  His Val Val Ala Asp  Ile Lys Ala 
    1430                 1435                 1440             


Ser Gln  Ile Leu Ala Ser Arg  Gly Ala Glu Leu Phe  Gln Ala Thr 
    1445                 1450                 1455             


Ile Val  Lys Ala Val Lys Ala  Arg Ile Glu Glu Glu  Lys Lys Ser 
    1460                 1465                 1470             


Met Asp  Gln Leu Lys Arg Gln  Met Asp Arg Ile Lys  Ala Arg Gln 
    1475                 1480                 1485             


Gln Lys  Tyr Lys Lys Gly Lys  Glu Arg Met Leu Ser  Leu Thr Gln 
    1490                 1495                 1500             


Glu Pro  Gly Glu Gly Gln Asp  Met Gln Lys Leu Ser  Glu Glu Asp 
    1505                 1510                 1515             


Asp Glu  Arg Glu Ala Asp Lys  Gln Lys Ala Lys Gly  Lys Lys Lys 
    1520                 1525                 1530             


Gln Trp  Trp Arg Pro Trp Val  Asp His Ala Ser Met  Val Arg Ser 
    1535                 1540                 1545             


Gly Asp  Tyr Tyr Leu Phe Glu  Thr Asp Ser Glu Glu  Glu Glu Glu 
    1550                 1555                 1560             


Glu Glu  Leu Lys Lys Glu Asp  Glu Glu Pro Pro Arg  Arg Ser Ala 
    1565                 1570                 1575             


Phe Gln  Phe Val Tyr Gln Ala  Trp Ile Thr Asp Pro  Lys Thr Ala 
    1580                 1585                 1590             


Leu Arg  Gln Arg His Lys Glu  Lys Lys Arg Ser Ala  Arg Glu Glu 
    1595                 1600                 1605             


Arg Lys  Arg Arg Arg Lys Gly  Ser Lys Glu Gly Pro  Val Glu Trp 
    1610                 1615                 1620             


Glu Asp  Arg Glu Asp Glu Pro  Ile Lys Lys Lys Ser  Asp Gly Pro 
    1625                 1630                 1635             


Asp Asn  Ile Ile Lys Arg Ile  Phe Asn Ile Leu Lys  Phe Thr Trp 
    1640                 1645                 1650             


Val Leu  Phe Leu Ala Thr Val  Asp Ser Phe Thr Thr  Trp Leu Asn 
    1655                 1660                 1665             


Ser Ile  Ser Arg Glu His Ile  Asp Ile Ser Thr Val  Leu Arg Ile 
    1670                 1675                 1680             


Glu Arg  Cys Met Leu Thr Arg  Glu Ile Lys Lys Gly  Asn Val Pro 
    1685                 1690                 1695             


Thr Arg  Glu Ser Ile His Met  Tyr Tyr Gln Asn His  Ile Met Asn 
    1700                 1705                 1710             


Leu Ser  Arg Glu Ser Gly Leu  Asp Thr Ile Asp Glu  His Pro Gly 
    1715                 1720                 1725             


Ala Ala  Ser Gly Ala Gln Thr  Ala His Arg Met Asp  Ser Leu Asp 
    1730                 1735                 1740             


Ser His  Asp Ser Ile Ser Ser  Glu Pro Thr Gln Cys  Thr Met Leu 
    1745                 1750                 1755             


Tyr Ser  Arg Gln Gly Thr Thr  Glu Thr Ile Glu Glu  Val Glu Ala 
    1760                 1765                 1770             


Glu Gln  Glu Glu Glu Ala Gly  Ser Thr Ala Pro Glu  Pro Arg Glu 
    1775                 1780                 1785             


Ala Lys  Glu Tyr Glu Ala Thr  Gly Tyr Asp Val Gly  Ala Met Gly 
    1790                 1795                 1800             


Ala Glu  Glu Ala Ser Leu Thr  Pro Glu Glu Glu Leu  Thr Gln Phe 
    1805                 1810                 1815             


Ser Thr  Leu Asp Gly Asp Val  Glu Ala Pro Pro Ser  Tyr Ser Lys 
    1820                 1825                 1830             


Ala Val  Ser Phe Glu His Leu  Ser Phe Gly Ser Gln  Asp Asp Ser 
    1835                 1840                 1845             


Ala Gly  Lys Asn Arg Met Ala  Val Ser Pro Asp Asp  Ser Arg Thr 
    1850                 1855                 1860             


Asp Lys  Leu Gly Ser Ser Ile  Leu Pro Pro Leu Thr  His Glu Leu 
    1865                 1870                 1875             


Thr Ala  Ser Glu Leu Leu Leu  Lys Lys Met Phe His  Asp Asp Glu 
    1880                 1885                 1890             


Leu Glu  Glu Ser Glu Lys Phe  Tyr Val Gly Gln Pro  Arg Phe Leu 
    1895                 1900                 1905             


Leu Leu  Phe Tyr Ala Met Tyr  Asn Thr Leu Val Ala  Arg Ser Glu 
    1910                 1915                 1920             


Met Val  Cys Tyr Phe Val Ile  Ile Leu Asn His Met  Val Ser Ala 
    1925                 1930                 1935             


Ser Met  Ile Thr Leu Leu Leu  Pro Ile Leu Ile Phe  Leu Trp Ala 
    1940                 1945                 1950             


Met Leu  Ser Val Pro Arg Pro  Ser Arg Arg Phe Trp  Met Met Ala 
    1955                 1960                 1965             


Ile Val  Tyr Thr Glu Val Ala  Ile Val Val Lys Tyr  Phe Phe Gln 
    1970                 1975                 1980             


Phe Gly  Phe Phe Pro Trp Asn  Lys Asn Val Glu Val  Asn Lys Asp 
    1985                 1990                 1995             


Lys Pro  Tyr His Pro Pro Asn  Ile Ile Gly Val Glu  Lys Lys Glu 
    2000                 2005                 2010             


Gly Tyr  Val Leu Tyr Asp Leu  Ile Gln Leu Leu Ala  Leu Phe Phe 
    2015                 2020                 2025             


His Arg  Ser Ile Leu Lys Cys  His Gly Leu Trp Asp  Glu Asp Asp 
    2030                 2035                 2040             


Met Thr  Glu Ser Gly Met Ala  Arg Glu Glu Ser Asp  Asp Glu Leu 
    2045                 2050                 2055             


Ser Leu  Gly His Gly Arg Arg  Asp Ser Ser Asp Ser  Leu Lys Ser 
    2060                 2065                 2070             


Ile Asn  Leu Ala Ala Ser Val  Glu Ser Val His Val  Thr Phe Pro 
    2075                 2080                 2085             


Glu Gln  Gln Thr Ala Val Arg  Arg Lys Arg Ser Gly  Ser Ser Ser 
    2090                 2095                 2100             


Glu Pro  Ser Gln Arg Ser Ser  Phe Ser Ser Asn Arg  Ser Gln Arg 
    2105                 2110                 2115             


Gly Ser  Thr Ser Thr Arg Asn  Ser Ser Gln Lys Gly  Ser Ser Val 
    2120                 2125                 2130             


Leu Ser  Ile Lys Gln Lys Gly  Lys Arg Glu Leu Tyr  Met Glu Lys 
    2135                 2140                 2145             


Leu Gln  Glu His Leu Ile Lys  Ala Lys Ala Phe Thr  Ile Lys Lys 
    2150                 2155                 2160             


Thr Leu  Glu Ile Tyr Val Pro  Ile Lys Gln Phe Phe  Tyr Asn Leu 
    2165                 2170                 2175             


Ile His  Pro Glu Tyr Ser Ala  Val Thr Asp Val Tyr  Val Leu Met 
    2180                 2185                 2190             


Phe Leu  Ala Asp Thr Val Asp  Phe Ile Ile Ile Val  Phe Gly Phe 
    2195                 2200                 2205             


Trp Ala  Phe Gly Lys His Ser  Ala Ala Ala Asp Ile  Thr Ser Ser 
    2210                 2215                 2220             


Leu Ser  Glu Asp Gln Val Pro  Gly Pro Phe Leu Val  Met Val Leu 
    2225                 2230                 2235             


Ile Gln  Phe Gly Thr Met Val  Val Asp Arg Ala Leu  Tyr Leu Arg 
    2240                 2245                 2250             


Lys Thr  Val Leu Gly Lys Val  Ile Phe Gln Val Ile  Leu Val Phe 
    2255                 2260                 2265             


Gly Ile  His Phe Trp Met Phe  Phe Ile Leu Pro Gly  Val Thr Glu 
    2270                 2275                 2280             


Arg Lys  Phe Ser Gln Asn Leu  Val Ala Gln Leu Trp  Tyr Phe Val 
    2285                 2290                 2295             


Lys Cys  Val Tyr Phe Gly Leu  Ser Ala Tyr Gln Ile  Arg Cys Gly 
    2300                 2305                 2310             


Tyr Pro  Thr Arg Val Leu Gly  Asn Phe Leu Thr Lys  Ser Tyr Asn 
    2315                 2320                 2325             


Tyr Val  Asn Leu Phe Leu Phe  Gln Gly Phe Arg Leu  Val Pro Phe 
    2330                 2335                 2340             


Leu Thr  Glu Leu Arg Ala Val  Met Asp Trp Val Trp  Thr Asp Thr 
    2345                 2350                 2355             


Thr Leu  Ser Leu Ser Ser Trp  Ile Cys Val Glu Asp  Ile Tyr Ala 
    2360                 2365                 2370             


His Ile  Phe Ile Leu Lys Cys  Trp Arg Glu Ser Glu  Lys Arg Tyr 
    2375                 2380                 2385             


Pro Gln  Pro Arg Gly Gln Lys  Lys Lys Lys Val Val  Lys Tyr Gly 
    2390                 2395                 2400             


Met Gly  Gly Met Ile Ile Val  Leu Leu Ile Cys Ile  Val Trp Phe 
    2405                 2410                 2415             


Pro Leu  Leu Phe Met Ser Leu  Ile Lys Ser Val Ala  Gly Val Ile 
    2420                 2425                 2430             


Asn Gln  Pro Leu Asp Val Ser  Val Thr Ile Thr Leu  Gly Gly Tyr 
    2435                 2440                 2445             


Gln Pro  Ile Phe Thr Met Ser  Ala Gln Gln Ser Gln  Leu Lys Val 
    2450                 2455                 2460             


Met Asp  Gln Gln Ser Phe Asn  Lys Phe Ile Gln Ala  Phe Ser Arg 
    2465                 2470                 2475             


Asp Thr  Gly Ala Met Gln Phe  Leu Glu Asn Tyr Glu  Lys Glu Asp 
    2480                 2485                 2490             


Ile Thr  Val Ala Glu Leu Glu  Gly Asn Ser Asn Ser  Leu Trp Thr 
    2495                 2500                 2505             


Ile Ser  Pro Pro Ser Lys Gln  Lys Met Ile His Glu  Leu Leu Asp 
    2510                 2515                 2520             


Pro Asn  Ser Ser Phe Ser Val  Val Phe Ser Trp Ser  Ile Gln Arg 
    2525                 2530                 2535             


Asn Leu  Ser Leu Gly Ala Lys  Ser Glu Ile Ala Thr  Asp Lys Leu 
    2540                 2545                 2550             


Ser Phe  Pro Leu Lys Asn Ile  Thr Arg Lys Asn Ile  Ala Lys Met 
    2555                 2560                 2565             


Ile Ala  Gly Asn Ser Thr Glu  Ser Ser Lys Thr Pro  Val Thr Ile 
    2570                 2575                 2580             


Glu Lys  Ile Tyr Pro Tyr Tyr  Val Lys Ala Pro Ser  Asp Ser Asn 
    2585                 2590                 2595             


Ser Lys  Pro Ile Lys Gln Leu  Leu Ser Glu Asn Asn  Phe Met Asp 
    2600                 2605                 2610             


Ile Thr  Ile Ile Leu Ser Arg  Asp Asn Thr Thr Lys  Tyr Asn Ser 
    2615                 2620                 2625             


Glu Trp  Trp Val Leu Asn Leu  Thr Gly Asn Arg Ile  Tyr Asn Pro 
    2630                 2635                 2640             


Asn Ser  Gln Ala Leu Glu Leu  Val Val Phe Asn Asp  Lys Val Ser 
    2645                 2650                 2655             


Pro Pro  Ser Leu Gly Phe Leu  Ala Gly Tyr Gly Ile  Met Gly Leu 
    2660                 2665                 2670             


Tyr Ala  Ser Val Val Leu Val  Ile Gly Lys Phe Val  Arg Glu Phe 
    2675                 2680                 2685             


Phe Ser  Gly Ile Ser His Ser  Ile Met Phe Glu Glu  Leu Pro Asn 
    2690                 2695                 2700             


Val Asp  Arg Ile Leu Lys Leu  Cys Thr Asp Ile Phe  Leu Val Arg 
    2705                 2710                 2715             


Glu Thr  Gly Glu Leu Glu Leu  Glu Glu Asp Leu Tyr  Ala Lys Leu 
    2720                 2725                 2730             


Ile Phe  Leu Tyr Arg Ser Pro  Glu Thr Met Ile Lys  Trp Thr Arg 
    2735                 2740                 2745             


Glu Lys  Thr Asn 
    2750         


<210>  21
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mus musculus primer

<400>  21
atggagccgc acgtgctg                                                     18


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mus musculus primer

<400>  22
ctactccctc tcacgtgtcc a                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mus musculus primer

<400>  23
atggcttcgg aagtggtgtg c                                                 21


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mus musculus primer

<400>  24
tcagtttgtt ttttctctag tccac                                             25


