                         SEQUENCE LISTING

<110>  The Research Foundation of State University of New York
       Ma, Yupo
 
<120>  METHOD FOR EX VIVO EXPANSION OF STEM CELLS AND THE USE OF SUCH 
       CELLS

<130>  2238/81894-A-PCT

<150>  US 61/376,122
<151>  2010-08-23

<160>  12    

<170>  PatentIn version 3.3

<210>  1
<211>  5143
<212>  DNA
<213>  Homo sapiens

<400>  1
ttattctgcc ccagctgatg tttgagccag catgtcgcgg aggaagcaag cgaagcctca     60

acatttccaa tccgaccccg aagtggcctc gctcccccgg cgagatggag acacagaaaa    120

gggtcaaccg agtcgcccta ctaagagcaa ggatgcccac gtctgtggcc ggtgctgtgc    180

cgagttcttt gaattatcag atcttctgct ccacaagaag aactgtacta aaaatcaatt    240

agttttaatc gtaaatgaaa atccagcctc cccacccgaa accttctccc ccagcccccc    300

tcctgataat cctgatgaac aaatgaatga cacagttaac aaaacagatc aagtggactg    360

cagcgacctt tcagaacaca acggacttga cagggaagag tccatggagg tggaggcccc    420

ggttgctaac aaaagcggca gcggcacttc cagcggcagc cacagcagta ccgccccaag    480

cagcagcagc agcagcagca gcagcagcgg cggcggcggc agctcctcca caggtacctc    540

agcgatcaca acctctctac ctcaactcgg ggacctgaca acactgggca acttctccgt    600

aatcaacagc aacgtcatca tcgagaacct ccagagcacc aaggtggcgg tggcccagtt    660

ctcccaggaa gcgaggtgcg gcggggcctc tgggggcaag ctggccgtcc cagccctcat    720

ggaacaactc ctagctctgc agcagcagca gatccaccag ctgcaattga tcgaacagat    780

tcgtcaccaa atattgctgt tggcttctca gaatgcagac ttgccaacat cttctagtcc    840

ttctcaaggt actttacgaa catctgccaa ccccttgtcc acgctaagtt cccatttatc    900

tcagcagctg gcagcagcag ctggattggc acagagcctc gccagccaat ctgccagcat    960

tagtggtgtg aaacagctac ccccaatcca gctacctcag agcagttctg gcaacaccat   1020

cattccatcc aacagcggct cttctcccaa tatgaacata ttggcagcgg cagttaccac   1080

cccgtcctct gaaaaagtgg cttcaagtgc tggggcctcc catgtcagca acccagcggt   1140

ctcatcatcg tcctcaccag cttttgcaat aagcagttta ttaagtcctg cgtctaatcc   1200

acttctacct cagcaagcct ccgctaactc ggttttcccc agccctttgc ccaacatcgg   1260

aacaactgca gaggatttaa actccttgtc tgccttggcc cagcaaagaa aaagcaagcc   1320

accaaatgtc actgcctttg aagcgaaaag tacttccgat gaggcattct tcaaacacaa   1380

gtgcaggttc tgcgcgaagg tctttgggag tgacagtgcc ttgcagatcc acttgcgttc   1440

ccataccgga gagaggccat tcaagtgcaa catctgcggg aacaggttct ccaccaaggg   1500

gaatctgaaa gtccactttc agcgccacaa agagaaatac cctcatatcc agatgaaccc   1560

ctatcctgtg cctgagcatt tggacaatat ccccacgagt actggcatcc catatggcat   1620

gtccatccct ccagagaagc cagtcaccag ctggctagac accaaaccag tcctgcctac   1680

tctgaccact tcagtcggcc tgccgttgcc cccaaccctc ccaagcctca tacccttcat   1740

caagacggaa gagccagccc ccatccccat cagccattct gccaccagcc ccccaggctc   1800

agtcaaaagt gactccgggg gccctgagtc agccacaaga aacctaggtg ggctcccaga   1860

ggaagccgaa gggtccactc tgccaccctc tggtggcaaa agcgaagaga gtggcatggt   1920

caccaactca gtcccgacgg cgagcagtag cgtcctgagc tccccagcgg cagactgcgg   1980

ccccgcgggc agtgccacca ccttcaccaa ccctttgttg ccgctcatgt ccgagcagtt   2040

caaggccaag tttccttttg ggggactcct ggactcagct caggcatcag agacgtccaa   2100

gcttcagcaa ctggtagaaa acattgacaa gaaggccact gaccccaatg agtgcatcat   2160

ctgccaccgg gttctcagct gccagagcgc cttgaaaatg cactacagga cacacactgg   2220

ggagaggccc tttaagtgta agatctgtgg ccgggctttc accacgaaag ggaatcttaa   2280

aacccactac agtgtccatc gtgctatgcc cccgctcaga gtccagcatt cctgccccat   2340

ctgccagaag aagttcacga acgctgtggt cctgcagcag cacatccgaa tgcatatggg   2400

aggccagatc cccaacaccc cagtccccga cagctactct gagtccatgg agtctgacac   2460

aggttccttt gatgagaaaa attttgatga cctagacaac ttctctgatg aaaacatgga   2520

agactgtcct gagggcagca tccctgatac acctaagtct gcagacgcct cccaagacag   2580

cttatcctct tcgcctttgc ccctcgagat gtcgagcatc gctgctttgg aaaatcagat   2640

gaagatgatc aatgctggcc tggcagagca gctacaggcc agcctgaagt cagtggagaa   2700

tgggtccatc gagggggatg tcctgaccaa tgattcatcc tcagtgggtg gtgacatgga   2760

aagccaaagt gctggcagcc cagccatctc agagtctacc tcttccatgc aggctctgtc   2820

cccgtccaac agcacgcagg agttccacaa gtcacccagc attgaggaga aaccacagag   2880

agcggtccca agcgagtttg ccaatggttt gtctcccacc ccagtgaatg gtggggcttt   2940

ggatttgaca tctagtcacg cagagaaaat catcaaagaa gattctttgg ggatcctctt   3000

cccttttaga gaccggggta aatttaaaaa cactgcttgt gacatttgtg gcaaaacatt   3060

tgcttgtcag agtgccttgg acattcacta tagaagtcat accaaagaga gaccatttat   3120

ttgcacagtt tgcaatcgtg gcttttccac aaagggtaat ttgaagcagc acatgttgac   3180

acatcagatg cgagatctgc catcccagct ctttgagccc agttccaacc ttggccccaa   3240

tcagaactca gcggtgattc ccgccaactc gttgtcatct ctcatcaaga cagaggtcaa   3300

cggcttcgtg catgtttctc ctcaggacag taaggacacc cccaccagtc acgtcccgtc   3360

tgggcctctg tcttcctctg ccacatcccc agttctgctc cctgctctgc ccaggagaac   3420

tcccaagcag cactactgca acacatgtgg caaaaccttc tcctcatcga gtgccctgca   3480

gattcacgag agaactcaca ctggagagaa accctttgct tgcactattt gtggaagagc   3540

tttcacgact aaaggcaatc ttaaggtaca catgggcact cacatgtgga atagcacccc   3600

tgcacgacgg ggtcggcggc tctctgtgga tggccccatg acatttctag gaggcaatcc   3660

cgtcaagttc ccagaaatgt tccagaagga tttggcggca agatcaggaa gtggggatcc   3720

ttccagcttc tggaatcagt atgcagcagc gctctccaac gggctggcga tgaaggccaa   3780

cgagatctcc gtcattcaga acggtggcat ccctccaatt cctggaagcc tcggcagtgg   3840

gaacagctca cctgttagtg ggctgacggg aaacctggag aggctccaga actcagagcc   3900

caatgctccc ctggccggcc tggagaaaat ggcaagcagt gagaacggaa ccaacttccg   3960

cttcacccgc ttcgtggagg acagcaagga gatcgtcacg agttaaagca gctcgggctg   4020

gagacatagc attcattcct gttcagaatg cgacctatgg tggcctccta ctccttgccc   4080

cccaccccgc cccgcccctt ccttctgttc cccagatcta tgaactacaa cattatgaag   4140

acattctttt gtaccttgtt caactttaga gttctaagaa agcttattta ttagcgatat   4200

aaccttgctt tgcaaacaga atgcaagcgt taactttggt cttctgtatt ttggactaaa   4260

tactaattga ctagagtgct gtaaacttgc tgtaacattt atggcaattg caagttgccc   4320

tgctaggcag ttgtaatctg gcattaactt attttctata tccagtttaa tatgaatctg   4380

gtgttgatgc aatgcctcag tgatgcatta gatctctaat aaagtctgta tatacatgta   4440

cactttgatc ctgctggaaa attttatcag caaacacatt gtctaatctt tcaaaacaga   4500

tttaaggaaa ggactgaaag tacagactga acagtgtggt tctttgaaag gtttggtttt   4560

ttaattttta ttctaaaatt caaccttttt ttttgtcgat ttaaccattt ccattttgaa   4620

ctgctatttg tattgtgctt tttacttgag tcgtcttcaa tgttaataag tttctgtaca   4680

gtaataagca cgcagaattc tttagagaaa aagaaaacaa gcgttgtttt ggtagttgaa   4740

actgagacgt aacattttgc cttgtaggta tattcacgat agaaaatgtg tgctggaatt   4800

tcacaatgct gctaagtata gcatcttgaa caaccttcag tggagaaaat gtagatgctc   4860

ttgtatatac aataagaaat atcactttca ttcaaatgta catatgttcc ttacaagagc   4920

aaatgcttct tcttgatcaa gagagcaggt atagtgtttg tttattttgt cttaggtatg   4980

gaagaaaaaa attggactgt tacatgcact ttcttggaaa gttgaaagga aagggggggt   5040

ccaatttctt taacatttaa tacttactaa caacagagat actgtaattt tactcaagta   5100

atcaaataca ttttttttgc aacagataaa acaaaatact gtg                     5143


<210>  2
<211>  5253
<212>  DNA
<213>  Homo sapiens

<400>  2
ctttggaggt tcagagctgc aagaagatgg ggactggtgt cggggcgcca gcgcctgacc     60

cgctggggtt gcggccgggg tggagagtgc tgctggccgc cagttgttcc ggagacggtg    120

caaacggacg gggaaagtgt cggggtctgg ctcgcaaaat ttatctccgc atctcttccc    180

acaacacttg caccctctgc cccccaaaat ctttctggag acacagaaaa gggtcaaccg    240

agtcgcccta ctaagagcaa ggatgcccac gtctgtggcc ggtgctgtgc cgagttcttt    300

gaattatcag atcttctgct ccacaagaag aactgtacta aaaatcaatt agttttaatc    360

gtaaatgaaa atccagcctc cccacccgaa accttctccc ccagcccccc tcctgataat    420

cctgatgaac aaatgaatga cacagttaac aaaacagatc aagtggactg cagcgacctt    480

tcagaacaca acggacttga cagggaagag tccatggagg tggaggcccc ggttgctaac    540

aaaagcggca gcggcacttc cagcggcagc cacagcagta ccgccccaag cagcagcagc    600

agcagcagca gcagcagcgg cggcggcggc agctcctcca caggtacctc agcgatcaca    660

acctctctac ctcaactcgg ggacctgaca acactgggca acttctccgt aatcaacagc    720

aacgtcatca tcgagaacct ccagagcacc aaggtggcgg tggcccagtt ctcccaggaa    780

gcgaggtgcg gcggggcctc tgggggcaag ctggccgtcc cagccctcat ggaacaactc    840

ctagctctgc agcagcagca gatccaccag ctgcaattga tcgaacagat tcgtcaccaa    900

atattgctgt tggcttctca gaatgcagac ttgccaacat cttctagtcc ttctcaaggt    960

actttacgaa catctgccaa ccccttgtcc acgctaagtt cccatttatc tcagcagctg   1020

gcagcagcag ctggattggc acagagcctc gccagccaat ctgccagcat tagtggtgtg   1080

aaacagctac ccccaatcca gctacctcag agcagttctg gcaacaccat cattccatcc   1140

aacagcggct cttctcccaa tatgaacata ttggcagcgg cagttaccac cccgtcctct   1200

gaaaaagtgg cttcaagtgc tggggcctcc catgtcagca acccagcggt ctcatcatcg   1260

tcctcaccag cttttgcaat aagcagttta ttaagtcctg cgtctaatcc acttctacct   1320

cagcaagcct ccgctaactc ggttttcccc agccctttgc ccaacatcgg aacaactgca   1380

gaggatttaa actccttgtc tgccttggcc cagcaaagaa aaagcaagcc accaaatgtc   1440

actgcctttg aagcgaaaag tacttccgat gaggcattct tcaaacacaa gtgcaggttc   1500

tgcgcgaagg tctttgggag tgacagtgcc ttgcagatcc acttgcgttc ccataccgga   1560

gagaggccat tcaagtgcaa catctgcggg aacaggttct ccaccaaggg gaatctgaaa   1620

gtccactttc agcgccacaa agagaaatac cctcatatcc agatgaaccc ctatcctgtg   1680

cctgagcatt tggacaatat ccccacgagt actggcatcc catatggcat gtccatccct   1740

ccagagaagc cagtcaccag ctggctagac accaaaccag tcctgcctac tctgaccact   1800

tcagtcggcc tgccgttgcc cccaaccctc ccaagcctca tacccttcat caagacggaa   1860

gagccagccc ccatccccat cagccattct gccaccagcc ccccaggctc agtcaaaagt   1920

gactccgggg gccctgagtc agccacaaga aacctaggtg ggctcccaga ggaagccgaa   1980

gggtccactc tgccaccctc tggtggcaaa agcgaagaga gtggcatggt caccaactca   2040

gtcccgacgg cgagcagtag cgtcctgagc tccccagcgg cagactgcgg ccccgcgggc   2100

agtgccacca ccttcaccaa ccctttgttg ccgctcatgt ccgagcagtt caaggccaag   2160

tttccttttg ggggactcct ggactcagct caggcatcag agacgtccaa gcttcagcaa   2220

ctggtagaaa acattgacaa gaaggccact gaccccaatg agtgcatcat ctgccaccgg   2280

gttctcagct gccagagcgc cttgaaaatg cactacagga cacacactgg ggagaggccc   2340

tttaagtgta agatctgtgg ccgggctttc accacgaaag ggaatcttaa aacccactac   2400

agtgtccatc gtgctatgcc cccgctcaga gtccagcatt cctgccccat ctgccagaag   2460

aagttcacga acgctgtggt cctgcagcag cacatccgaa tgcatatggg aggccagatc   2520

cccaacaccc cagtccccga cagctactct gagtccatgg agtctgacac aggttccttt   2580

gatgagaaaa attttgatga cctagacaac ttctctgatg aaaacatgga agactgtcct   2640

gagggcagca tccctgatac acctaagtct gcagacgcct cccaagacag cttatcctct   2700

tcgcctttgc ccctcgagat gtcgagcatc gctgctttgg aaaatcagat gaagatgatc   2760

aatgctggcc tggcagagca gctacaggcc agcctgaagt cagtggagaa tgggtccatc   2820

gagggggatg tcctgaccaa tgattcatcc tcagtgggtg gtgacatgga aagccaaagt   2880

gctggcagcc cagccatctc agagtctacc tcttccatgc aggctctgtc cccgtccaac   2940

agcacgcagg agttccacaa gtcacccagc attgaggaga aaccacagag agcggtccca   3000

agcgagtttg ccaatggttt gtctcccacc ccagtgaatg gtggggcttt ggatttgaca   3060

tctagtcacg cagagaaaat catcaaagaa gattctttgg ggatcctctt cccttttaga   3120

gaccggggta aatttaaaaa cactgcttgt gacatttgtg gcaaaacatt tgcttgtcag   3180

agtgccttgg acattcacta tagaagtcat accaaagaga gaccatttat ttgcacagtt   3240

tgcaatcgtg gcttttccac aaagggtaat ttgaagcagc acatgttgac acatcagatg   3300

cgagatctgc catcccagct ctttgagccc agttccaacc ttggccccaa tcagaactca   3360

gcggtgattc ccgccaactc gttgtcatct ctcatcaaga cagaggtcaa cggcttcgtg   3420

catgtttctc ctcaggacag taaggacacc cccaccagtc acgtcccgtc tgggcctctg   3480

tcttcctctg ccacatcccc agttctgctc cctgctctgc ccaggagaac tcccaagcag   3540

cactactgca acacatgtgg caaaaccttc tcctcatcga gtgccctgca gattcacgag   3600

agaactcaca ctggagagaa accctttgct tgcactattt gtggaagagc tttcacgact   3660

aaaggcaatc ttaaggtaca catgggcact cacatgtgga atagcacccc tgcacgacgg   3720

ggtcggcggc tctctgtgga tggccccatg acatttctag gaggcaatcc cgtcaagttc   3780

ccagaaatgt tccagaagga tttggcggca agatcaggaa gtggggatcc ttccagcttc   3840

tggaatcagt atgcagcagc gctctccaac gggctggcga tgaaggccaa cgagatctcc   3900

gtcattcaga acggtggcat ccctccaatt cctggaagcc tcggcagtgg gaacagctca   3960

cctgttagtg ggctgacggg aaacctggag aggctccaga actcagagcc caatgctccc   4020

ctggccggcc tggagaaaat ggcaagcagt gagaacggaa ccaacttccg cttcacccgc   4080

ttcgtggagg acagcaagga gatcgtcacg agttaaagca gctcgggctg gagacatagc   4140

attcattcct gttcagaatg cgacctatgg tggcctccta ctccttgccc cccaccccgc   4200

cccgcccctt ccttctgttc cccagatcta tgaactacaa cattatgaag acattctttt   4260

gtaccttgtt caactttaga gttctaagaa agcttattta ttagcgatat aaccttgctt   4320

tgcaaacaga atgcaagcgt taactttggt cttctgtatt ttggactaaa tactaattga   4380

ctagagtgct gtaaacttgc tgtaacattt atggcaattg caagttgccc tgctaggcag   4440

ttgtaatctg gcattaactt attttctata tccagtttaa tatgaatctg gtgttgatgc   4500

aatgcctcag tgatgcatta gatctctaat aaagtctgta tatacatgta cactttgatc   4560

ctgctggaaa attttatcag caaacacatt gtctaatctt tcaaaacaga tttaaggaaa   4620

ggactgaaag tacagactga acagtgtggt tctttgaaag gtttggtttt ttaattttta   4680

ttctaaaatt caaccttttt ttttgtcgat ttaaccattt ccattttgaa ctgctatttg   4740

tattgtgctt tttacttgag tcgtcttcaa tgttaataag tttctgtaca gtaataagca   4800

cgcagaattc tttagagaaa aagaaaacaa gcgttgtttt ggtagttgaa actgagacgt   4860

aacattttgc cttgtaggta tattcacgat agaaaatgtg tgctggaatt tcacaatgct   4920

gctaagtata gcatcttgaa caaccttcag tggagaaaat gtagatgctc ttgtatatac   4980

aataagaaat atcactttca ttcaaatgta catatgttcc ttacaagagc aaatgcttct   5040

tcttgatcaa gagagcaggt atagtgtttg tttattttgt cttaggtatg gaagaaaaaa   5100

attggactgt tacatgcact ttcttggaaa gttgaaagga aagggggggt ccaatttctt   5160

taacatttaa tacttactaa caacagagat actgtaattt tactcaagta atcaaataca   5220

ttttttttgc aacagataaa acaaaatact gtg                                5253


<210>  3
<211>  4931
<212>  DNA
<213>  Homo sapiens

<400>  3
gagctgcaga agcgtaggga agaagctgaa gaaaaaaagg gggcgtctcc cctttaaaga     60

cttgcaaaga ttgagagaga aagagagaga gtcaagaaca gagaatcaga gagagagaga    120

gagtctgtgt ctctgggaaa gaagaacatc tctgcttcac agtgatttgc gctgggggag    180

aggcatcaat tggcttcgga cccaaggggg agacgagacc aggtcacccc ggttaagacc    240

aagtgagcgt tgcccctccc tctcccaact ctctacccgg gaatgtctcg gcgaaagcag    300

cggaaacccc aacagttaat ctcggactgc gaaggtccca gcgcgtctga gaacggtgat    360

gctagcgagg aggatcaccc ccaagtctgt gccaagtgct gcgcacaatt cactgaccca    420

actgaattcc tcgcccacca gaacgcatgt tctactgacc ctcctgtaat ggtgataatt    480

gggggccagg agaaccccaa caactcttcg gcctcctctg aaccccggcc tgagggtcac    540

aataatcctc aggtcatgga cacagagcat agcaaccccc cagattctgg gtcctccgtg    600

cccacggatc ccacctgggg cccagagagg agaggagagg agtctccagg gcatttcctg    660

gtcgctgcca caggtacagc ggctggggga ggcgggggcc tgatcttggc cagtcccaag    720

ctgggagcaa ccccattacc tccagaatcg acccctgcac cccctcctcc tccaccaccc    780

cctccgcccc caggggtagg cagtggccac ttgaatatcc ccctgatctt ggaagagcta    840

cgggtgctgc agcagcggca gatccatcag atgcagatga ctgagcaaat ctgcaggcag    900

gtgctgttgc ttggctcctt aggccagacg gtgggtgccc ctgccagtcc ctcagagcta    960

cctgggacag ggactgcctc ttccaccaag cccctactac ccctcttcag ccccatcaag   1020

cctgtccaaa ccagcaagac actggcatct tcctcctcct cctcctcttc ctcttcaggg   1080

gcagaaacgc ccaagcaggc cttcttccac ctttaccacc cactggggtc acagcatcct   1140

ttctctgctg gaggggttgg gcgaagccac aaacccaccc ctgccccttc cccagccttg   1200

ccaggcagca cagatcagct gattgcctcg cctcatctgg cattcccaag caccacggga   1260

ctactggcag cacagtgtct tggggcagcc cgaggccttg aggccactgc ctccccaggg   1320

ctcctgaagc caaagaatgg aagtggtgag ctgagctacg gagaagtgat gggtcccttg   1380

gagaagcctg gtggaaggca caaatgccgc ttctgtgcca aagtatttgg cagtgacagt   1440

gccctgcaga tccaccttcg ttcccacacg ggtgagaggc cctataagtg caatgtctgt   1500

ggaaaccgtt ttaccacccg tggcaacctc aaagtgcatt tccaccggca tcgtgagaag   1560

tacccacatg tgcagatgaa cccacaccca gtaccagagc acctagacta tgtcattacc   1620

agcagtggct tgccttatgg tatgtccgtg ccaccagaga aggccgagga ggaggcagcc   1680

actccaggtg gaggggttga gcgcaagcct ctggtggcct ccacaacagc actcagtgcc   1740

acagagagcc tgactctgct ctccaccagt gcaggcacag ccacggctcc aggactccct   1800

gctttcaata agtttgtgct catgaaagca gtggaaccca agaataaagc tgatgaaaac   1860

acccccccag ggagtgaggg ctcagccatc agtggagtgg cagaaagtag cacggcaact   1920

cgcatgcaac taagtaagtt ggtgacttca ctaccaagct gggcactgct taccaaccac   1980

ttcaagtcca ctggcagctt ccccttcccc tatgtgctag agcccttggg ggcctcaccc   2040

tctgagacat caaagctgca gcaactggta gaaaagattg accggcaagg agctgtggcg   2100

gtgacctcag ctgcctcagg agcccccacc acctctgccc ctgcaccttc atcctcagcc   2160

tcttctggac ctaaccagtg tgtcatctgt ctccgagtgc ttagctgtcc tcgggcccta   2220

cgccttcatt atggccaaca tggaggtgag aggcccttca aatgcaaagt gtgtggcaga   2280

gccttctcca ccaggggtaa tctgcgtgca catttcgtgg gccacaaggc cagtccagct   2340

gcccgggcac agaattcctg ccccatctgc cagaagaagt tcaccaatgc tgtcactctg   2400

cagcagcatg tccggatgca cctggggggc cagatcccca acggtggtac tgcactccct   2460

gaaggtggag gagctgctca ggagaatggc tccgagcaat ctacagtctc cggggcaggg   2520

agtttccccc agcagcagtc ccagcagcca tcaccggaag aggagttgtc tgaggaggag   2580

gaagaggagg atgaggaaga agaggaagat gtgactgatg aagattccct ggcagggaga   2640

ggctcagaga gtggaggtga gaaggcaata tcagtgagag gtgattcaga agaggcatct   2700

ggggcagagg aggaggtggg gacagtggcg gcagcagcca cagctgggaa ggagatggac   2760

agtaatgaga aaactactca acagtcttct ttgccaccac caccaccacc tgacagcctg   2820

gatcagcctc agccaatgga gcagggaagc agtggtgttt taggaggcaa ggaagagggg   2880

ggcaaaccgg agagaagctc aagtccggca tcagcactca ccccagaagg ggaagccacc   2940

agcgtgacct tggtagagga gctgagcctg caggaggcaa tgagaaagga gccaggagag   3000

agcagcagca gaaaggcctg cgaagtgtgt ggccaggcct ttccctccca ggcagctctg   3060

gaggagcatc agaagaccca ccccaaggag gggccgctct tcacttgtgt tttctgcagg   3120

cagggctttc ttgagcgggc taccctcaag aagcatatgc tcctggcaca ccaccaggta   3180

cagccctttg ccccccatgg ccctcagaat attgctgctc tttctctagt ccctggctgt   3240

tcgccttcca tcacctccac agggctctcc ccctttcccc gaaaagatga ccccacgatc   3300

ccatgagcct gtttttctgt acctgctgct ctttgtccca cagagcagaa acagcttcac   3360

aaaaggacct cccagagtta tgagccctga ttttgtcttt ttctctaagt tcttaacatg   3420

ttatgtccct agtggctttt ctgtagtccc tgagcttgga aattactgtg cttacaaggg   3480

gatggccccc taaggaattt ttcttccctc ctcattcttt gtacctgagg aacatagatt   3540

ctctgcagct ttctcaaggg gaaccctctc cagcttccct ggtgtgaccc ttcttccccc   3600

tcctctctcc tctccctttc cctttggtag gtgcacctga gcacctacat ttggcattgc   3660

agcctagcca aaaagggctg gcagctgtct ctggagggcc cagtgccact cctctggggt   3720

gacctttctg ctcagctggt gggtatgggt cccctatctt tctagaacca gtatgtggca   3780

ttcctgtcaa atggcctgcc catgaagccc tggaattcca gctccacctc cactaccact   3840

ccaagcctgg ccccaccagt gctgtttggc ctaggaactg tggctgggaa ggtgcctcca   3900

acaatgggat ccagggaagc caaggagaag acagcccccc tcctatttca gcctcctgca   3960

cccaaggcag tgcctgagaa gcccatcata gacaagaagt agcaaactgt acattccttc   4020

ttcctccccc tgctccagaa ggtgccggta ctgaagatgc tccagtaatt ggtgacccaa   4080

ccctaggaag tagggagaaa tgaaggaagg gcataggaaa attttcccag taaatcccct   4140

gatggtcaca ttaaggtaaa ggttttggct ggtcagtgtg ccaagacctc tccagcttct   4200

cattcatgat gacctctcaa agttgggaaa caagctgatt tcttgccaag aggtctccca   4260

ggagatattt gggaaatgtg aagttcgtat ctttaaggag catttttggt cagcatggtt   4320

gatgaactaa tgatgagaga gttaaggaat gttgctagaa catagggctt gctggtacct   4380

atgtgactaa gaaagggaca tgatgtaagg gaaaaggcct caaattcttg tgaatgtgga   4440

cattctcgtt aatattcttt tgggctaata gtgacatagt gtgcagaggt gtaccaggga   4500

tcatggggga tttcctagca ctagtatgct tctagtttta gataactccc tcctttattc   4560

cctggcccct tgtattttcc ttatcttcct ctttcaagac ccctacccat tttgcctatc   4620

cgtaggctgg ggcttgtgtc tttgtcattg tctggttctt aagagtccca gctccaggtg   4680

gcgtcctccc tgcctctccg tcttgtaatg agttgtagta tttactctta acataggatc   4740

atttggaaca ggagttctga ggaggagaga gtgagggttt tgctattgac tgacttgaac   4800

gatggcttct cctcaagctg taggctccag agcttcctaa cctagtaaaa tgtcaagaac   4860

agacgggaga tattagtgtc tttccctcta tcattaaagg tgttttaacc aaaaaaaaaa   4920

aaaaaaaaaa a                                                        4931


<210>  4
<211>  4775
<212>  DNA
<213>  Homo sapiens

<400>  4
atgtctcggc gcaagcaggc caagccccag cacctcaagt cggacgagga gctgctgccg     60

cctgacgggg ctcccgagca cgccgccccg ggggaaggtg cggaggacgc agacagcggg    120

cccgagagcc gcagcggggg cgaggagacc agcgtgtgcg agaaatgctg cgccgagttc    180

ttcaagtggg cggacttcct ggagcaccag cggagctgca ccaagctccc gcccgtgctg    240

atcgtgcacg aggacgcgcc cgcgccgccc cccgaggact tccccgagcc ttcgcccgcc    300

agctccccca gcgagcgcgc cgaaagcgag gcggccgagg aggcgggtgc ggagggcgcg    360

gagggcgagg ccaggccggt ggagaaggag gccgagccca tggacgcgga acccgcgggg    420

gacacgcgcg cgccccggcc cccgcctgcg gcccctgcac ccccaacgcc cgcctacggc    480

gcgcccagca ccaacgtgac cctggaggcg ctgctgagca ccaaggtggc ggtggcgcag    540

ttctcgcagg gcgcgcgcgc ggcaggcggc tcgggagcag gtggaggcgt ggcagctgca    600

gccgtgcccc tgatcctgga acagctcatg gccctgcagc agcagcagat ccaccagctg    660

cagctcatcg agcagatccg cagccaggtg gccctcatgc agcgcccgcc gccgcggccc    720

tcactcagcc ccgcggccgc cccgagcgca ccgggcccgg cccccagcca gctgcccggg    780

ctggccgcgc tcccgctgtc ggccggggcc cctgccgccg ccatcgcggg ctcgggcccc    840

gccgccccgg ccgccttcga gggcgcgcag ccgctgtccc ggcccgagtc tggcgccagc    900

acccccggcg gccctgcgga gcccagcgcg cccgccgccc ccagcgccgc ccctgccccc    960

gctgcccccg ccccggcgcc agcgccgcag agcgcagcct cgtcgcagcc gcagagcgca   1020

tccacgccgc ctgccctggc cccggggtcc ctgctgggtg cggcgcccgg cctgccaagt   1080

ccgcttctac ctcagacttc cgccagcggc gtcatcttcc ccaacccgct ggtcagcatc   1140

gcggccacgg ccaacgctct ggacccgctg tccgcgctca tgaagcaccg caagggcaag   1200

ccgcccaatg tgtcggtgtt cgagcccaaa gccagcgccg aggacccgtt cttcaagcac   1260

aaatgccgct tctgcgccaa ggtcttcggc agcgacagcg cgctccagat ccacctgcgc   1320

tcgcacacag gcgagcggcc cttcaagtgc aacatctgcg ggaaccgctt ctccaccaaa   1380

ggcaacctga aggtgcactt ccagaggcac aaggagaagt acccccacat ccagatgaac   1440

ccttacccgg tccccgagta cctggacaac gtgcccacct gctcgggcat cccctacggc   1500

atgtcgctgc cccccgagaa gcccgtgacc acctggctgg acagcaagcc cgtgctgccc   1560

accgtgccca cgtccgtggg gctgcaactg ccgcccactg tccctggcgc gcacggctac   1620

gccgactctc ccagcgccac cccagccagc cgctccccgc agaggccctc gcccgcctcc   1680

agcgagtgcg cctccttgtc cccaggcctc aaccacgtgg agtccggcgt gtcggccacc   1740

gccgagtccc cacagtcgct cctcggcggg ccgcccctca ctaaagccga gcccgtcagc   1800

ctgccctgca ccaacgccag ggccggggac gctcccgtgg gcgcgcaggc tagcgctgca   1860

cccacatcgg tggacggcgc acccacgagc ctcggcagcc ccgggctgcc cgccgtctcc   1920

gagcagttca aggcccagtt tccgttcggg gggctgctag actcgatgca aacgtcggaa   1980

acctcgaagc tgcagcagct ggtggagaac atcgacaaga agatgacgga cccgaaccag   2040

tgcgtcatct gccaccgggt gctgagctgc cagagcgcgc tgaagatgca ctaccggacg   2100

cacacggggg agcggccgtt caagtgcaag atctgcggcc gcgccttcac caccaagggc   2160

aacctcaaga cgcacttcgg cgtgcaccgt gcaaagccgc ccctgcgcgt gcagcactcc   2220

tgccccatct gccagaagaa gttcaccaac gccgtggtcc tgcagcagca catccgcatg   2280

cacatgggcg gccagatccc caacacgccg ctgccggagg gcttccagga tgccatggac   2340

tccgagctgg cctacgacga caagaacgcg gagaccctga gcagctacga tgacgacatg   2400

gacgagaact ccatggagga cgacgctgag ctgaaggacg cggccaccga cccggccaag   2460

ccactcctgt cctacgcggg gtcctgcccg ccctccccgc cctcggtcat ctccagcatt   2520

gccgccctgg agaaccagat gaagatgatc gactcggtca tgagctgcca gcagctgacc   2580

ggcctcaagt ccgtggagaa cgggtccggg gagagtgacc gcctgagcaa cgactcctcg   2640

tcggccgtgg gcgacctgga gagccgcagc gcgggcagcc ccgccctgtc cgagtcctcg   2700

tcctcgcagg ccctgtcgcc ggcccccagc aatggtgaga gcttccgctc caagtccccg   2760

ggcctgggcg ccccggagga gccccaggaa atcccgctca agaccgagag gccggacagc   2820

ccagccgccg ccccgggcag cggaggcgcc cctggccgcg cgggcatcaa ggaggaggcg   2880

cccttcagcc tgctgttcct gagcagggag cggggtaagt gtcccagcac tgtgtgtggt   2940

gtctgtggca agccttttgc ttgcaagagc gcgttggaaa tccactaccg cagccatact   3000

aaggagcggc cattcgtctg cgcgctctgc aggcgagggt gctccactat gggtaattta   3060

aaacagcact tactgacaca cagattgaaa gagctgcctt ctcagttatt tgaccccaac   3120

tttgctctag gtcccagcca aagcactcct agcctgatct ccagcgccgc acccaccatg   3180

atcaaaatgg aagtgaacgg tcacggcaag gccatggcgc tgggcgaggg tcccccgctg   3240

cccgcgggcg tccaggtccc cgccgggcct cagacagtga tgggcccggg cctggcgccc   3300

atgctggccc ccccaccgcg ccggacgccc aagcagcaca actgccagtc gtgcgggaag   3360

accttctcct cggccagcgc cctgcagatc catgagcgca cgcacaccgg cgagaagccg   3420

ttcggctgca ccatctgcgg ccgggccttc accactaagg gcaacctcaa ggtgcacatg   3480

gggacacaca tgtggaataa cgcccccgcg agacgcggcc gccgcctgtc tgtggagaac   3540

cccatggctc tcctaggggg tgatgccctg aagttctctg aaatgttcca gaaggacctg   3600

gcagctcggg caatgaacgt cgaccccagt ttttggaacc agtatgctgc agccatcact   3660

aacgggctcg ccatgaagaa caacgagatc tccgtcatcc agaacggcgg catcccccag   3720

ctccccgtga gtcttggggg cagcgccctc ccccctctgg gcagcatggc cagtgggatg   3780

gacaaagcac gcactggcag tagcccaccc atcgtcagct tggacaaagc gagctcagaa   3840

acagcagcca gccgcccatt cacgcggttt atcgaggata acaaggagat tggtatcaac   3900

tagccagtga ctcgctcatc tgccctgccc aggcccacgt tttgaagttg gagcatcagg   3960

cctccgacct ttcttgcctc ggttctcatt acactttcac ccatagcaga aaacactttg   4020

tgcggctgcc gagaggtggt cttgtaagcg ctgcatggcg ctcccttcaa cagcaagcct   4080

gactgttctc gagaactctg caatctttta aataagcttc cttcaaaaaa aaaagtgctt   4140

ggaaaaccgc cttaggaaca gaaagagctc agaccatgtc cacttccttt ctcctgaaac   4200

ctaataatct ctccgaggga gaaaggggtt ctctgcggta ttccagtgaa actcatttga   4260

tggtttcttt tgaattagtt agacacttga acggtgtttt ttagaactct tcatgttaaa   4320

gacgtggttt agtactccca atgctgtgta tcatgacact atcttcgtct gtagtattta   4380

tgatgttaag ataatgcggg taacagacaa tataatagcc ccgaccttaa acgaagcttt   4440

tgtactgcag aatacatctg gctgtgtgat tttttttttt aagcaagatt tgttttacta   4500

taaataagtg gattatttca atgcaggcaa aattgtgaag ttctgttggg aaagatagca   4560

tgcttttcgt gtgcaagtac ctgtcagtaa taagcctttt tttttttttt ttttaattta   4620

aatgtttgta gctgctatgt ggacagttgt tttctagtgt ggtctgtagc ccaataactg   4680

gggaacgagt tacagacaaa catcaccgta aatgactcac aacattataa acagttgtga   4740

gaaaatattt cacattatca aagctgtaca ataaa                              4775


<210>  5
<211>  3162
<212>  DNA
<213>  Homo sapiens

<400>  5
atgtcgaggc gcaagcaggc gaaaccccag cacatcaact cggaggagga ccagggcgag     60

cagcagccgc agcagcagac cccggagttt gcagatgcgg ccccagcggc gcccgcggcg    120

ggggagctgg gtgctccagt gaaccaccca gggaatgacg aggtggcgag tgaggatgaa    180

gccacagtaa agcggcttcg tcgggaggag acgcacgtct gtgagaaatg ctgtgcggag    240

ttcttcagca tctctgagtt cctggaacat aagaaaaatt gcactaaaaa tccacctgtc    300

ctcatcatga atgacagcga ggggcctgtg ccttcagaag acttctccgg agctgtactg    360

agccaccagc ccaccagtcc cggcagtaag gactgtcaca gggagaatgg cggcagctca    420

gaggacatga aggagaagcc ggatgcggag tctgtggtgt acctaaagac agagacagcc    480

ctgccaccca ccccccagga cataagctat ttagccaaag gcaaagtggc caacactaat    540

gtgaccttgc aggcactacg gggcaccaag gtggcggtga atcagcggag cgcggatgca    600

ctccctgccc ccgtgcctgg tgccaacagc atcccgtggg tcctcgagca gatcttgtgt    660

ctgcagcagc agcagctaca gcagatccag ctcaccgagc agatccgcat ccaggtgaac    720

atgtgggcct cccacgccct ccactcaagc ggggcagggg ccgacactct gaagaccttg    780

ggcagccaca tgtctcagca ggtttctgca gctgtggctt tgctcagcca gaaagctgga    840

agccaaggtc tgtctctgga tgccttgaaa caagccaagc tacctcacgc caacatccct    900

tctgccacca gctccctgtc cccagggctg gcacccttca ctctgaagcc ggatgggacc    960

cgggtgctcc cgaacgtcat gtcccgcctc ccgagcgctt tgcttcctca ggccccgggc   1020

tcggtgctct tccagagccc tttctccact gtggcgctag acacatccaa gaaagggaag   1080

gggaagccac cgaacatctc cgcggtggat gtcaaaccca aagacgaggc ggccctctac   1140

aagcacaagt gtaagtactg tagcaaggtt tttgggactg atagctcctt gcagatccac   1200

ctccgctccc acactggaga gagacccttc gtgtgctctg tctgtggtca tcgcttcacc   1260

accaagggca acctcaaggt gcactttcac cgacatcccc aggtgaaggc aaacccccag   1320

ctgtttgccg agttccagga caaagtggcg gccggcaatg gcatccccta tgcactctct   1380

gtacctgacc ccatagatga accgagtctt tctttagaca gcaaacctgt ccttgtaacc   1440

acctctgtag ggctacctca gaatctttct tcggggacta atcccaagga cctcacgggt   1500

ggctccttgc ccggtgacct gcagcctggg ccttctccag aaagtgaggg tggacccaca   1560

ctccctgggg tgggaccaaa ctataattcc ccaagggctg gtggcttcca agggagtggg   1620

acccctgagc cagggtcaga gaccctgaaa ttgcagcagt tggtggagaa cattgacaag   1680

gccaccactg atcccaacga atgtctcatt tgccaccgag tcttaagctg tcagagctcc   1740

ctcaagatgc attatcgcac ccacaccggg gagagaccgt tccagtgtaa gatctgtggc   1800

cgagcctttt ctaccaaagg taacctgaag acacaccttg gggttcaccg aaccaacaca   1860

tccattaaga cgcagcattc gtgccccatc tgccagaaga agttcactaa tgccgtgatg   1920

ctgcagcaac atattcggat gcacatgggc ggtcagattc ccaacacgcc cctgccagag   1980

aatccctgtg actttacggg ttctgagcca atgaccgtgg gtgagaacgg cagcaccggc   2040

gctatctgcc atgatgatgt catcgaaagc atcgatgtag aggaagtcag ctcccaggag   2100

gctcccagca gctcctccaa ggtccccacg cctcttccca gcatccactc ggcatcaccc   2160

acgctagggt ttgccatgat ggcttcctta gatgccccag ggaaagtggg tcctgcccct   2220

tttaacctgc agcgccaggg cagcagagaa aacggttccg tggagagcga tggcttgacc   2280

aacgactcat cctcgctgat gggagaccag gagtatcaga gccgaagccc agatatcctg   2340

gaaaccacat ccttccaggc actctccccg gccaatagtc aagccgaaag catcaagtca   2400

aagtctcccg atgctgggag caaagcagag agctccgaga acagccgcac tgagatggaa   2460

ggtcggagca gtctcccttc cacgtttatc cgagccccgc cgacctatgt caaggttgaa   2520

gttcctggca catttgtggg accctcgaca ttgtccccag ggatgacccc tttgttagca   2580

gcccagccac gccgacaggc caagcaacat ggctgcacac ggtgtgggaa gaacttctcg   2640

tctgctagcg ctcttcagat ccacgagcgg actcacactg gagagaagcc ttttgtgtgc   2700

aacatttgtg ggcgagcttt taccaccaaa ggcaacttaa aggttcacta catgacacac   2760

ggggcgaaca ataactcagc ccgccgtgga aggaagttgg ccatcgagaa caccatggct   2820

ctgttaggta cggacggaaa aagagtctca gaaatctttc ccaaggaaat cctggcccct   2880

tcagtgaatg tggaccctgt tgtgtggaac cagtacacca gcatgctcaa tggcggtctg   2940

gccgtgaaga ccaatgagat ctctgtgatc cagagtgggg gggttcctac cctcccggtt   3000

tccttggggg ccacctccgt tgtgaataac gccactgtct ccaagatgga tggctcccag   3060

tcgggtatca gtgcagatgt ggaaaaacca agtgctactg acggcgttcc caaacaccag   3120

tttcctcact tcctggaaga aaacaagatt gcggtcagct aa                      3162


<210>  6
<211>  1851
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (337)..(337)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (421)..(421)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1317)..(1317)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1326)..(1326)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1331)..(1331)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1334)..(1334)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1367)..(1367)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1805)..(1805)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1838)..(1838)
<223>  n is a, c, g, or t

<400>  6
atgtcgaggc gcaagcaggc gaaaccccag cacatcaact cggaggagga ccagggcgag     60

cagcagccgc agcagcagac cccggagttt gcagatgcgg ccccagcggc gcccgcggcg    120

ggggagctgg gtgctccagt gaaccaccca gggaatgacg aggtggcgag tgaggatgaa    180

gccacagtaa agcggcttcg tcgggaggag acgcacgtct gtgagaaatg ctgtgcggag    240

ttcttcagca tctctgagtt cctggaacat aagaaaaatt gcactaaaaa tccacctgtc    300

ctcatcatga atgacagcga ggggcctgtg ccttcanaag acttctccgg agctgtactg    360

agccaccagc ccaccagtcc cggcagtgag gactgtcaca gggagaatgg cggcagctca    420

naggacataa aggagaagcc ggatgcggag tctgtggtgt acctaaagac agagacagcc    480

ctgccaccca ccccccagga cataagctat ttagccaaag gcaaagtggc caacactaac    540

gtgaccttgc aggcactacg gggcaccaag gtggcggtga atcagcggag cgcggatgca    600

ctccctgccc ccgtgcctgg tgccaacagc atcccgtggg tcctcgagca gatcttgtgt    660

ctgcagcagc agcagctaca gcagatccag ctcaccgagc agatccgcat ccaggtgaac    720

atgtgggcct cccacgccct ccactcaagc ggggcagggg ccgacactct gaagaccttg    780

ggcagccaca tgtctcagca ggtttctgca gctgtggctt tgctcagcca gaaagctgga    840

agccaaggtc tgtctctgga tgccttgaaa caagccaagc tacctcacgc caacatccct    900

tctgccacca gctccctgtc cccagggctg gcacccttca ctctgaagcc ggatgggacc    960

cgggtgctcc cgaacgtcat gtcccgcctc ccgagcgctt tgcttcctca ggccccgggc   1020

tcggtgctct tccagagccc tttctccact gtggcgctag acacatccaa gaaagggaag   1080

gggaagccac cgaacatctc cgcggtggat gtcaaaccca aagacgaggc ggccctctac   1140

aagcacaagt gtcggagcag tctcccttcc acgtttatcc gagccccgcc gacctatgtc   1200

aaggttgaag ttcctggcac atttgtggga ccctcgacat tgtccccagg gatgacccct   1260

ttgttagcag cccagccacg cggacaggcc aagcaacatg gctgcacacg gtgtggnaag   1320

aacttntcgt ntgntagcgc tcttcagatc cacgagcgga ctcacantgg agagaagcct   1380

tttgtgtgca acatttgtgg gcgagctttt accaccaaag gcaacttaaa ggttcactac   1440

atgacacacg gggcgaacaa taactcagcc cgccgtggaa ggaagttggc catcgagaac   1500

accatggctc tgttaggtac ggacggaaaa agagtctcag aaatctttcc caaggaaatc   1560

ctggcccctt cagtgaatgt ggaccctgtt gtgtggaacc agtacaccag catgctcaat   1620

ggcggtctgg ccgtgaagac caatgagatc tctgtgatcc agagtggggg ggttcctacc   1680

ctcccggttt ccttgggggc cacctccgtt gtgaataacg ccactgtctc caagatggat   1740

ggctcccagt cgggtatcag tgcagatgtg gaaaaaccaa gtgctactga cggcgttccc   1800

aaacnccagt ttcctcactt cctggaagaa aacaagantg cggtcagcta a            1851


<210>  7
<211>  1320
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Phe Gln Ser Asp Pro 
1               5                   10                  15      


Glu Val Ala Ser Leu Pro Arg Arg Asp Gly Asp Thr Glu Lys Gly Gln 
            20                  25                  30          


Pro Ser Arg Pro Thr Lys Ser Lys Asp Ala His Val Cys Gly Arg Cys 
        35                  40                  45              


Cys Ala Glu Phe Phe Glu Leu Ser Asp Leu Leu Leu His Lys Lys Asn 
    50                  55                  60                  


Cys Thr Lys Asn Gln Leu Val Leu Ile Val Asn Glu Asn Pro Ala Ser 
65                  70                  75                  80  


Pro Pro Glu Thr Phe Ser Pro Ser Pro Pro Pro Asp Asn Pro Asp Glu 
                85                  90                  95      


Gln Met Asn Asp Thr Val Asn Lys Thr Asp Gln Val Asp Cys Ser Asp 
            100                 105                 110         


Leu Ser Glu His Asn Gly Leu Asp Arg Glu Glu Ser Met Glu Val Glu 
        115                 120                 125             


Ala Pro Val Ala Asn Lys Ser Gly Ser Gly Thr Ser Ser Gly Ser His 
    130                 135                 140                 


Ser Ser Thr Ala Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Ser Ser Thr Gly Thr Ser Ala Ile Thr Thr Ser Leu 
                165                 170                 175     


Pro Gln Leu Gly Asp Leu Thr Thr Leu Gly Asn Phe Ser Val Ile Asn 
            180                 185                 190         


Ser Asn Val Ile Ile Glu Asn Leu Gln Ser Thr Lys Val Ala Val Ala 
        195                 200                 205             


Gln Phe Ser Gln Glu Ala Arg Cys Gly Gly Ala Ser Gly Gly Lys Leu 
    210                 215                 220                 


Ala Val Pro Ala Leu Met Glu Gln Leu Leu Ala Leu Gln Gln Gln Gln 
225                 230                 235                 240 


Ile His Gln Leu Gln Leu Ile Glu Gln Ile Arg His Gln Ile Leu Leu 
                245                 250                 255     


Leu Ala Ser Gln Asn Ala Asp Leu Pro Thr Ser Ser Ser Pro Ser Gln 
            260                 265                 270         


Gly Thr Leu Arg Thr Ser Ala Asn Pro Leu Ser Thr Leu Ser Ser His 
        275                 280                 285             


Leu Ser Gln Gln Leu Ala Ala Ala Ala Gly Leu Ala Gln Ser Leu Ala 
    290                 295                 300                 


Ser Gln Ser Ala Ser Ile Ser Gly Val Lys Gln Leu Pro Pro Ile Gln 
305                 310                 315                 320 


Leu Pro Gln Ser Ser Ser Gly Asn Thr Ile Ile Pro Ser Asn Ser Gly 
                325                 330                 335     


Ser Ser Pro Asn Met Asn Ile Leu Ala Ala Ala Val Thr Thr Pro Ser 
            340                 345                 350         


Ser Glu Lys Val Ala Ser Ser Ala Gly Ala Ser His Val Ser Asn Pro 
        355                 360                 365             


Ala Val Ser Ser Ser Ser Ser Pro Ala Phe Ala Ile Ser Ser Leu Leu 
    370                 375                 380                 


Ser Pro Ala Ser Asn Pro Leu Leu Pro Gln Gln Ala Ser Ala Asn Ser 
385                 390                 395                 400 


Val Phe Pro Ser Pro Leu Pro Asn Ile Gly Thr Thr Ala Glu Asp Leu 
                405                 410                 415     


Asn Ser Leu Ser Ala Leu Ala Gln Gln Arg Lys Ser Lys Pro Pro Asn 
            420                 425                 430         


Val Thr Ala Phe Glu Ala Lys Ser Thr Ser Asp Glu Ala Phe Phe Lys 
        435                 440                 445             


His Lys Cys Arg Phe Cys Ala Lys Val Phe Gly Ser Asp Ser Ala Leu 
    450                 455                 460                 


Gln Ile His Leu Arg Ser His Thr Gly Glu Arg Pro Phe Lys Cys Asn 
465                 470                 475                 480 


Ile Cys Gly Asn Arg Phe Ser Thr Lys Gly Asn Leu Lys Val His Phe 
                485                 490                 495     


Gln Arg His Lys Glu Lys Tyr Pro His Ile Gln Met Asn Pro Tyr Pro 
            500                 505                 510         


Val Pro Glu His Leu Asp Asn Ile Pro Thr Ser Thr Gly Ile Pro Tyr 
        515                 520                 525             


Gly Met Ser Ile Pro Pro Glu Lys Pro Val Thr Ser Trp Leu Asp Thr 
    530                 535                 540                 


Lys Pro Val Leu Pro Thr Leu Thr Thr Ser Val Gly Leu Pro Leu Pro 
545                 550                 555                 560 


Pro Thr Leu Pro Ser Leu Ile Pro Phe Ile Lys Thr Glu Glu Pro Ala 
                565                 570                 575     


Pro Ile Pro Ile Ser His Ser Ala Thr Ser Pro Pro Gly Ser Val Lys 
            580                 585                 590         


Ser Asp Ser Gly Gly Pro Glu Ser Ala Thr Arg Asn Leu Gly Gly Leu 
        595                 600                 605             


Pro Glu Glu Ala Glu Gly Ser Thr Leu Pro Pro Ser Gly Gly Lys Ser 
    610                 615                 620                 


Glu Glu Ser Gly Met Val Thr Asn Ser Val Pro Thr Ala Ser Ser Ser 
625                 630                 635                 640 


Val Leu Ser Ser Pro Ala Ala Asp Cys Gly Pro Ala Gly Ser Ala Thr 
                645                 650                 655     


Thr Phe Thr Asn Pro Leu Leu Pro Leu Met Ser Glu Gln Phe Lys Ala 
            660                 665                 670         


Lys Phe Pro Phe Gly Gly Leu Leu Asp Ser Ala Gln Ala Ser Glu Thr 
        675                 680                 685             


Ser Lys Leu Gln Gln Leu Val Glu Asn Ile Asp Lys Lys Ala Thr Asp 
    690                 695                 700                 


Pro Asn Glu Cys Ile Ile Cys His Arg Val Leu Ser Cys Gln Ser Ala 
705                 710                 715                 720 


Leu Lys Met His Tyr Arg Thr His Thr Gly Glu Arg Pro Phe Lys Cys 
                725                 730                 735     


Lys Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn Leu Lys Thr His 
            740                 745                 750         


Tyr Ser Val His Arg Ala Met Pro Pro Leu Arg Val Gln His Ser Cys 
        755                 760                 765             


Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Val Leu Gln Gln His 
    770                 775                 780                 


Ile Arg Met His Met Gly Gly Gln Ile Pro Asn Thr Pro Val Pro Asp 
785                 790                 795                 800 


Ser Tyr Ser Glu Ser Met Glu Ser Asp Thr Gly Ser Phe Asp Glu Lys 
                805                 810                 815     


Asn Phe Asp Asp Leu Asp Asn Phe Ser Asp Glu Asn Met Glu Asp Cys 
            820                 825                 830         


Pro Glu Gly Ser Ile Pro Asp Thr Pro Lys Ser Ala Asp Ala Ser Gln 
        835                 840                 845             


Asp Ser Leu Ser Ser Ser Pro Leu Pro Leu Glu Met Ser Ser Ile Ala 
    850                 855                 860                 


Ala Leu Glu Asn Gln Met Lys Met Ile Asn Ala Gly Leu Ala Glu Gln 
865                 870                 875                 880 


Leu Gln Ala Ser Leu Lys Ser Val Glu Asn Gly Ser Ile Glu Gly Asp 
                885                 890                 895     


Val Leu Thr Asn Asp Ser Ser Ser Val Gly Gly Asp Met Glu Ser Gln 
            900                 905                 910         


Ser Ala Gly Ser Pro Ala Ile Ser Glu Ser Thr Ser Ser Met Gln Ala 
        915                 920                 925             


Leu Ser Pro Ser Asn Ser Thr Gln Glu Phe His Lys Ser Pro Ser Ile 
    930                 935                 940                 


Glu Glu Lys Pro Gln Arg Ala Val Pro Ser Glu Phe Ala Asn Gly Leu 
945                 950                 955                 960 


Ser Pro Thr Pro Val Asn Gly Gly Ala Leu Asp Leu Thr Ser Ser His 
                965                 970                 975     


Ala Glu Lys Ile Ile Lys Glu Asp Ser Leu Gly Ile Leu Phe Pro Phe 
            980                 985                 990         


Arg Asp Arg Gly Lys Phe Lys Asn  Thr Ala Cys Asp Ile  Cys Gly Lys 
        995                 1000                 1005             


Thr Phe  Ala Cys Gln Ser Ala  Leu Asp Ile His Tyr  Arg Ser His 
    1010                 1015                 1020             


Thr Lys  Glu Arg Pro Phe Ile  Cys Thr Val Cys Asn  Arg Gly Phe 
    1025                 1030                 1035             


Ser Thr  Lys Gly Asn Leu Lys  Gln His Met Leu Thr  His Gln Met 
    1040                 1045                 1050             


Arg Asp  Leu Pro Ser Gln Leu  Phe Glu Pro Ser Ser  Asn Leu Gly 
    1055                 1060                 1065             


Pro Asn  Gln Asn Ser Ala Val  Ile Pro Ala Asn Ser  Leu Ser Ser 
    1070                 1075                 1080             


Leu Ile  Lys Thr Glu Val Asn  Gly Phe Val His Val  Ser Pro Gln 
    1085                 1090                 1095             


Asp Ser  Lys Asp Thr Pro Thr  Ser His Val Pro Ser  Gly Pro Leu 
    1100                 1105                 1110             


Ser Ser  Ser Ala Thr Ser Pro  Val Leu Leu Pro Ala  Leu Pro Arg 
    1115                 1120                 1125             


Arg Thr  Pro Lys Gln His Tyr  Cys Asn Thr Cys Gly  Lys Thr Phe 
    1130                 1135                 1140             


Ser Ser  Ser Ser Ala Leu Gln  Ile His Glu Arg Thr  His Thr Gly 
    1145                 1150                 1155             


Glu Lys  Pro Phe Ala Cys Thr  Ile Cys Gly Arg Ala  Phe Thr Thr 
    1160                 1165                 1170             


Lys Gly  Asn Leu Lys Val His  Met Gly Thr His Met  Trp Asn Ser 
    1175                 1180                 1185             


Thr Pro  Ala Arg Arg Gly Arg  Arg Leu Ser Val Asp  Gly Pro Met 
    1190                 1195                 1200             


Thr Phe  Leu Gly Gly Asn Pro  Val Lys Phe Pro Glu  Met Phe Gln 
    1205                 1210                 1215             


Lys Asp  Leu Ala Ala Arg Ser  Gly Ser Gly Asp Pro  Ser Ser Phe 
    1220                 1225                 1230             


Trp Asn  Gln Tyr Ala Ala Ala  Leu Ser Asn Gly Leu  Ala Met Lys 
    1235                 1240                 1245             


Ala Asn  Glu Ile Ser Val Ile  Gln Asn Gly Gly Ile  Pro Pro Ile 
    1250                 1255                 1260             


Pro Gly  Ser Leu Gly Ser Gly  Asn Ser Ser Pro Val  Ser Gly Leu 
    1265                 1270                 1275             


Thr Gly  Asn Leu Glu Arg Leu  Gln Asn Ser Glu Pro  Asn Ala Pro 
    1280                 1285                 1290             


Leu Ala  Gly Leu Glu Lys Met  Ala Ser Ser Glu Asn  Gly Thr Asn 
    1295                 1300                 1305             


Phe Arg  Phe Thr Arg Phe Val  Glu Asp Ser Lys Glu  
    1310                 1315                 1320 


<210>  8
<211>  1227
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asn Asp Thr Val Asn Lys Thr Asp Gln Val Asp Cys Ser Asp Leu 
1               5                   10                  15      


Ser Glu His Asn Gly Leu Asp Arg Glu Glu Ser Met Glu Val Glu Ala 
            20                  25                  30          


Pro Val Ala Asn Lys Ser Gly Ser Gly Thr Ser Ser Gly Ser His Ser 
        35                  40                  45              


Ser Thr Ala Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Ser Ser Thr Gly Thr Ser Ala Ile Thr Thr Ser Leu Pro 
65                  70                  75                  80  


Gln Leu Gly Asp Leu Thr Thr Leu Gly Asn Phe Ser Val Ile Asn Ser 
                85                  90                  95      


Asn Val Ile Ile Glu Asn Leu Gln Ser Thr Lys Val Ala Val Ala Gln 
            100                 105                 110         


Phe Ser Gln Glu Ala Arg Cys Gly Gly Ala Ser Gly Gly Lys Leu Ala 
        115                 120                 125             


Val Pro Ala Leu Met Glu Gln Leu Leu Ala Leu Gln Gln Gln Gln Ile 
    130                 135                 140                 


His Gln Leu Gln Leu Ile Glu Gln Ile Arg His Gln Ile Leu Leu Leu 
145                 150                 155                 160 


Ala Ser Gln Asn Ala Asp Leu Pro Thr Ser Ser Ser Pro Ser Gln Gly 
                165                 170                 175     


Thr Leu Arg Thr Ser Ala Asn Pro Leu Ser Thr Leu Ser Ser His Leu 
            180                 185                 190         


Ser Gln Gln Leu Ala Ala Ala Ala Gly Leu Ala Gln Ser Leu Ala Ser 
        195                 200                 205             


Gln Ser Ala Ser Ile Ser Gly Val Lys Gln Leu Pro Pro Ile Gln Leu 
    210                 215                 220                 


Pro Gln Ser Ser Ser Gly Asn Thr Ile Ile Pro Ser Asn Ser Gly Ser 
225                 230                 235                 240 


Ser Pro Asn Met Asn Ile Leu Ala Ala Ala Val Thr Thr Pro Ser Ser 
                245                 250                 255     


Glu Lys Val Ala Ser Ser Ala Gly Ala Ser His Val Ser Asn Pro Ala 
            260                 265                 270         


Val Ser Ser Ser Ser Ser Pro Ala Phe Ala Ile Ser Ser Leu Leu Ser 
        275                 280                 285             


Pro Ala Ser Asn Pro Leu Leu Pro Gln Gln Ala Ser Ala Asn Ser Val 
    290                 295                 300                 


Phe Pro Ser Pro Leu Pro Asn Ile Gly Thr Thr Ala Glu Asp Leu Asn 
305                 310                 315                 320 


Ser Leu Ser Ala Leu Ala Gln Gln Arg Lys Ser Lys Pro Pro Asn Val 
                325                 330                 335     


Thr Ala Phe Glu Ala Lys Ser Thr Ser Asp Glu Ala Phe Phe Lys His 
            340                 345                 350         


Lys Cys Arg Phe Cys Ala Lys Val Phe Gly Ser Asp Ser Ala Leu Gln 
        355                 360                 365             


Ile His Leu Arg Ser His Thr Gly Glu Arg Pro Phe Lys Cys Asn Ile 
    370                 375                 380                 


Cys Gly Asn Arg Phe Ser Thr Lys Gly Asn Leu Lys Val His Phe Gln 
385                 390                 395                 400 


Arg His Lys Glu Lys Tyr Pro His Ile Gln Met Asn Pro Tyr Pro Val 
                405                 410                 415     


Pro Glu His Leu Asp Asn Ile Pro Thr Ser Thr Gly Ile Pro Tyr Gly 
            420                 425                 430         


Met Ser Ile Pro Pro Glu Lys Pro Val Thr Ser Trp Leu Asp Thr Lys 
        435                 440                 445             


Pro Val Leu Pro Thr Leu Thr Thr Ser Val Gly Leu Pro Leu Pro Pro 
    450                 455                 460                 


Thr Leu Pro Ser Leu Ile Pro Phe Ile Lys Thr Glu Glu Pro Ala Pro 
465                 470                 475                 480 


Ile Pro Ile Ser His Ser Ala Thr Ser Pro Pro Gly Ser Val Lys Ser 
                485                 490                 495     


Asp Ser Gly Gly Pro Glu Ser Ala Thr Arg Asn Leu Gly Gly Leu Pro 
            500                 505                 510         


Glu Glu Ala Glu Gly Ser Thr Leu Pro Pro Ser Gly Gly Lys Ser Glu 
        515                 520                 525             


Glu Ser Gly Met Val Thr Asn Ser Val Pro Thr Ala Ser Ser Ser Val 
    530                 535                 540                 


Leu Ser Ser Pro Ala Ala Asp Cys Gly Pro Ala Gly Ser Ala Thr Thr 
545                 550                 555                 560 


Phe Thr Asn Pro Leu Leu Pro Leu Met Ser Glu Gln Phe Lys Ala Lys 
                565                 570                 575     


Phe Pro Phe Gly Gly Leu Leu Asp Ser Ala Gln Ala Ser Glu Thr Ser 
            580                 585                 590         


Lys Leu Gln Gln Leu Val Glu Asn Ile Asp Lys Lys Ala Thr Asp Pro 
        595                 600                 605             


Asn Glu Cys Ile Ile Cys His Arg Val Leu Ser Cys Gln Ser Ala Leu 
    610                 615                 620                 


Lys Met His Tyr Arg Thr His Thr Gly Glu Arg Pro Phe Lys Cys Lys 
625                 630                 635                 640 


Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn Leu Lys Thr His Tyr 
                645                 650                 655     


Ser Val His Arg Ala Met Pro Pro Leu Arg Val Gln His Ser Cys Pro 
            660                 665                 670         


Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Val Leu Gln Gln His Ile 
        675                 680                 685             


Arg Met His Met Gly Gly Gln Ile Pro Asn Thr Pro Val Pro Asp Ser 
    690                 695                 700                 


Tyr Ser Glu Ser Met Glu Ser Asp Thr Gly Ser Phe Asp Glu Lys Asn 
705                 710                 715                 720 


Phe Asp Asp Leu Asp Asn Phe Ser Asp Glu Asn Met Glu Asp Cys Pro 
                725                 730                 735     


Glu Gly Ser Ile Pro Asp Thr Pro Lys Ser Ala Asp Ala Ser Gln Asp 
            740                 745                 750         


Ser Leu Ser Ser Ser Pro Leu Pro Leu Glu Met Ser Ser Ile Ala Ala 
        755                 760                 765             


Leu Glu Asn Gln Met Lys Met Ile Asn Ala Gly Leu Ala Glu Gln Leu 
    770                 775                 780                 


Gln Ala Ser Leu Lys Ser Val Glu Asn Gly Ser Ile Glu Gly Asp Val 
785                 790                 795                 800 


Leu Thr Asn Asp Ser Ser Ser Val Gly Gly Asp Met Glu Ser Gln Ser 
                805                 810                 815     


Ala Gly Ser Pro Ala Ile Ser Glu Ser Thr Ser Ser Met Gln Ala Leu 
            820                 825                 830         


Ser Pro Ser Asn Ser Thr Gln Glu Phe His Lys Ser Pro Ser Ile Glu 
        835                 840                 845             


Glu Lys Pro Gln Arg Ala Val Pro Ser Glu Phe Ala Asn Gly Leu Ser 
    850                 855                 860                 


Pro Thr Pro Val Asn Gly Gly Ala Leu Asp Leu Thr Ser Ser His Ala 
865                 870                 875                 880 


Glu Lys Ile Ile Lys Glu Asp Ser Leu Gly Ile Leu Phe Pro Phe Arg 
                885                 890                 895     


Asp Arg Gly Lys Phe Lys Asn Thr Ala Cys Asp Ile Cys Gly Lys Thr 
            900                 905                 910         


Phe Ala Cys Gln Ser Ala Leu Asp Ile His Tyr Arg Ser His Thr Lys 
        915                 920                 925             


Glu Arg Pro Phe Ile Cys Thr Val Cys Asn Arg Gly Phe Ser Thr Lys 
    930                 935                 940                 


Gly Asn Leu Lys Gln His Met Leu Thr His Gln Met Arg Asp Leu Pro 
945                 950                 955                 960 


Ser Gln Leu Phe Glu Pro Ser Ser Asn Leu Gly Pro Asn Gln Asn Ser 
                965                 970                 975     


Ala Val Ile Pro Ala Asn Ser Leu Ser Ser Leu Ile Lys Thr Glu Val 
            980                 985                 990         


Asn Gly Phe Val His Val Ser Pro  Gln Asp Ser Lys Asp  Thr Pro Thr 
        995                 1000                 1005             


Ser His  Val Pro Ser Gly Pro  Leu Ser Ser Ser Ala  Thr Ser Pro 
    1010                 1015                 1020             


Val Leu  Leu Pro Ala Leu Pro  Arg Arg Thr Pro Lys  Gln His Tyr 
    1025                 1030                 1035             


Cys Asn  Thr Cys Gly Lys Thr  Phe Ser Ser Ser Ser  Ala Leu Gln 
    1040                 1045                 1050             


Ile His  Glu Arg Thr His Thr  Gly Glu Lys Pro Phe  Ala Cys Thr 
    1055                 1060                 1065             


Ile Cys  Gly Arg Ala Phe Thr  Thr Lys Gly Asn Leu  Lys Val His 
    1070                 1075                 1080             


Met Gly  Thr His Met Trp Asn  Ser Thr Pro Ala Arg  Arg Gly Arg 
    1085                 1090                 1095             


Arg Leu  Ser Val Asp Gly Pro  Met Thr Phe Leu Gly  Gly Asn Pro 
    1100                 1105                 1110             


Val Lys  Phe Pro Glu Met Phe  Gln Lys Asp Leu Ala  Ala Arg Ser 
    1115                 1120                 1125             


Gly Ser  Gly Asp Pro Ser Ser  Phe Trp Asn Gln Tyr  Ala Ala Ala 
    1130                 1135                 1140             


Leu Ser  Asn Gly Leu Ala Met  Lys Ala Asn Glu Ile  Ser Val Ile 
    1145                 1150                 1155             


Gln Asn  Gly Gly Ile Pro Pro  Ile Pro Gly Ser Leu  Gly Ser Gly 
    1160                 1165                 1170             


Asn Ser  Ser Pro Val Ser Gly  Leu Thr Gly Asn Leu  Glu Arg Leu 
    1175                 1180                 1185             


Gln Asn  Ser Glu Pro Asn Ala  Pro Leu Ala Gly Leu  Glu Lys Met 
    1190                 1195                 1200             


Ala Ser  Ser Glu Asn Gly Thr  Asn Phe Arg Phe Thr  Arg Phe Val 
    1205                 1210                 1215             


Glu Asp  Ser Lys Glu Ile Val  Thr Ser 
    1220                 1225         


<210>  9
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Arg Arg Lys Gln Arg Lys Pro Gln Gln Leu Ile Ser Asp Cys 
1               5                   10                  15      


Glu Gly Pro Ser Ala Ser Glu Asn Gly Asp Ala Ser Glu Glu Asp His 
            20                  25                  30          


Pro Gln Val Cys Ala Lys Cys Cys Ala Gln Phe Thr Asp Pro Thr Glu 
        35                  40                  45              


Phe Leu Ala His Gln Asn Ala Cys Ser Thr Asp Pro Pro Val Met Val 
    50                  55                  60                  


Ile Ile Gly Gly Gln Glu Asn Pro Asn Asn Ser Ser Ala Ser Ser Glu 
65                  70                  75                  80  


Pro Arg Pro Glu Gly His Asn Asn Pro Gln Val Met Asp Thr Glu His 
                85                  90                  95      


Ser Asn Pro Pro Asp Ser Gly Ser Ser Val Pro Thr Asp Pro Thr Trp 
            100                 105                 110         


Gly Pro Glu Arg Arg Gly Glu Glu Ser Pro Gly His Phe Leu Val Ala 
        115                 120                 125             


Ala Thr Gly Thr Ala Ala Gly Gly Gly Gly Gly Leu Ile Leu Ala Ser 
    130                 135                 140                 


Pro Lys Leu Gly Ala Thr Pro Leu Pro Pro Glu Ser Thr Pro Ala Pro 
145                 150                 155                 160 


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Val Gly Ser Gly His 
                165                 170                 175     


Leu Asn Ile Pro Leu Ile Leu Glu Glu Leu Arg Val Leu Gln Gln Arg 
            180                 185                 190         


Gln Ile His Gln Met Gln Met Thr Glu Gln Ile Cys Arg Gln Val Leu 
        195                 200                 205             


Leu Leu Gly Ser Leu Gly Gln Thr Val Gly Ala Pro Ala Ser Pro Ser 
    210                 215                 220                 


Glu Leu Pro Gly Thr Gly Thr Ala Ser Ser Thr Lys Pro Leu Leu Pro 
225                 230                 235                 240 


Leu Phe Ser Pro Ile Lys Pro Val Gln Thr Ser Lys Thr Leu Ala Ser 
                245                 250                 255     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Ala Glu Thr Pro Lys Gln 
            260                 265                 270         


Ala Phe Phe His Leu Tyr His Pro Leu Gly Ser Gln His Pro Phe Ser 
        275                 280                 285             


Ala Gly Gly Val Gly Arg Ser His Lys Pro Thr Pro Ala Pro Ser Pro 
    290                 295                 300                 


Ala Leu Pro Gly Ser Thr Asp Gln Leu Ile Ala Ser Pro His Leu Ala 
305                 310                 315                 320 


Phe Pro Ser Thr Thr Gly Leu Leu Ala Ala Gln Cys Leu Gly Ala Ala 
                325                 330                 335     


Arg Gly Leu Glu Ala Thr Ala Ser Pro Gly Leu Leu Lys Pro Lys Asn 
            340                 345                 350         


Gly Ser Gly Glu Leu Ser Tyr Gly Glu Val Met Gly Pro Leu Glu Lys 
        355                 360                 365             


Pro Gly Gly Arg His Lys Cys Arg Phe Cys Ala Lys Val Phe Gly Ser 
    370                 375                 380                 


Asp Ser Ala Leu Gln Ile His Leu Arg Ser His Thr Gly Glu Arg Pro 
385                 390                 395                 400 


Tyr Lys Cys Asn Val Cys Gly Asn Arg Phe Thr Thr Arg Gly Asn Leu 
                405                 410                 415     


Lys Val His Phe His Arg His Arg Glu Lys Tyr Pro His Val Gln Met 
            420                 425                 430         


Asn Pro His Pro Val Pro Glu His Leu Asp Tyr Val Ile Thr Ser Ser 
        435                 440                 445             


Gly Leu Pro Tyr Gly Met Ser Val Pro Pro Glu Lys Ala Glu Glu Glu 
    450                 455                 460                 


Ala Ala Thr Pro Gly Gly Gly Val Glu Arg Lys Pro Leu Val Ala Ser 
465                 470                 475                 480 


Thr Thr Ala Leu Ser Ala Thr Glu Ser Leu Thr Leu Leu Ser Thr Ser 
                485                 490                 495     


Ala Gly Thr Ala Thr Ala Pro Gly Leu Pro Ala Phe Asn Lys Phe Val 
            500                 505                 510         


Leu Met Lys Ala Val Glu Pro Lys Asn Lys Ala Asp Glu Asn Thr Pro 
        515                 520                 525             


Pro Gly Ser Glu Gly Ser Ala Ile Ser Gly Val Ala Glu Ser Ser Thr 
    530                 535                 540                 


Ala Thr Arg Met Gln Leu Ser Lys Leu Val Thr Ser Leu Pro Ser Trp 
545                 550                 555                 560 


Ala Leu Leu Thr Asn His Phe Lys Ser Thr Gly Ser Phe Pro Phe Pro 
                565                 570                 575     


Tyr Val Leu Glu Pro Leu Gly Ala Ser Pro Ser Glu Thr Ser Lys Leu 
            580                 585                 590         


Gln Gln Leu Val Glu Lys Ile Asp Arg Gln Gly Ala Val Ala Val Thr 
        595                 600                 605             


Ser Ala Ala Ser Gly Ala Pro Thr Thr Ser Ala Pro Ala Pro Ser Ser 
    610                 615                 620                 


Ser Ala Ser Ser Gly Pro Asn Gln Cys Val Ile Cys Leu Arg Val Leu 
625                 630                 635                 640 


Ser Cys Pro Arg Ala Leu Arg Leu His Tyr Gly Gln His Gly Gly Glu 
                645                 650                 655     


Arg Pro Phe Lys Cys Lys Val Cys Gly Arg Ala Phe Ser Thr Arg Gly 
            660                 665                 670         


Asn Leu Arg Ala His Phe Val Gly His Lys Ala Ser Pro Ala Ala Arg 
        675                 680                 685             


Ala Gln Asn Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val 
    690                 695                 700                 


Thr Leu Gln Gln His Val Arg Met His Leu Gly Gly Gln Ile Pro Asn 
705                 710                 715                 720 


Gly Gly Thr Ala Leu Pro Glu Gly Gly Gly Ala Ala Gln Glu Asn Gly 
                725                 730                 735     


Ser Glu Gln Ser Thr Val Ser Gly Ala Gly Ser Phe Pro Gln Gln Gln 
            740                 745                 750         


Ser Gln Gln Pro Ser Pro Glu Glu Glu Leu Ser Glu Glu Glu Glu Glu 
        755                 760                 765             


Glu Asp Glu Glu Glu Glu Glu Asp Val Thr Asp Glu Asp Ser Leu Ala 
    770                 775                 780                 


Gly Arg Gly Ser Glu Ser Gly Gly Glu Lys Ala Ile Ser Val Arg Gly 
785                 790                 795                 800 


Asp Ser Glu Glu Ala Ser Gly Ala Glu Glu Glu Val Gly Thr Val Ala 
                805                 810                 815     


Ala Ala Ala Thr Ala Gly Lys Glu Met Asp Ser Asn Glu Lys Thr Thr 
            820                 825                 830         


Gln Gln Ser Ser Leu Pro Pro Pro Pro Pro Pro Asp Ser Leu Asp Gln 
        835                 840                 845             


Pro Gln Pro Met Glu Gln Gly Ser Ser Gly Val Leu Gly Gly Lys Glu 
    850                 855                 860                 


Glu Gly Gly Lys Pro Glu Arg Ser Ser Ser Pro Ala Ser Ala Leu Thr 
865                 870                 875                 880 


Pro Glu Gly Glu Ala Thr Ser Val Thr Leu Val Glu Glu Leu Ser Leu 
                885                 890                 895     


Gln Glu Ala Met Arg Lys Glu Pro Gly Glu Ser Ser Ser Arg Lys Ala 
            900                 905                 910         


Cys Glu Val Cys Gly Gln Ala Phe Pro Ser Gln Ala Ala Leu Glu Glu 
        915                 920                 925             


His Gln Lys Thr His Pro Lys Glu Gly Pro Leu Phe Thr Cys Val Phe 
    930                 935                 940                 


Cys Arg Gln Gly Phe Leu Glu Arg Ala Thr Leu Lys Lys His Met Leu 
945                 950                 955                 960 


Leu Ala His His Gln Val Gln Pro Phe Ala Pro His Gly Pro Gln Asn 
                965                 970                 975     


Ile Ala Ala Leu Ser Leu Val Pro Gly Cys Ser Pro Ser Ile Thr Ser 
            980                 985                 990         


Thr Gly Leu Ser Pro Phe Pro Arg  Lys Asp Asp Pro Thr  Ile Pro 
        995                 1000                 1005         


<210>  10
<211>  1300
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Leu Lys Ser Asp Glu 
1               5                   10                  15      


Glu Leu Leu Pro Pro Asp Gly Ala Pro Glu His Ala Ala Pro Gly Glu 
            20                  25                  30          


Gly Ala Glu Asp Ala Asp Ser Gly Pro Glu Ser Arg Ser Gly Gly Glu 
        35                  40                  45              


Glu Thr Ser Val Cys Glu Lys Cys Cys Ala Glu Phe Phe Lys Trp Ala 
    50                  55                  60                  


Asp Phe Leu Glu His Gln Arg Ser Cys Thr Lys Leu Pro Pro Val Leu 
65                  70                  75                  80  


Ile Val His Glu Asp Ala Pro Ala Pro Pro Pro Glu Asp Phe Pro Glu 
                85                  90                  95      


Pro Ser Pro Ala Ser Ser Pro Ser Glu Arg Ala Glu Ser Glu Ala Ala 
            100                 105                 110         


Glu Glu Ala Gly Ala Glu Gly Ala Glu Gly Glu Ala Arg Pro Val Glu 
        115                 120                 125             


Lys Glu Ala Glu Pro Met Asp Ala Glu Pro Ala Gly Asp Thr Arg Ala 
    130                 135                 140                 


Pro Arg Pro Pro Pro Ala Ala Pro Ala Pro Pro Thr Pro Ala Tyr Gly 
145                 150                 155                 160 


Ala Pro Ser Thr Asn Val Thr Leu Glu Ala Leu Leu Ser Thr Lys Val 
                165                 170                 175     


Ala Val Ala Gln Phe Ser Gln Gly Ala Arg Ala Ala Gly Gly Ser Gly 
            180                 185                 190         


Ala Gly Gly Gly Val Ala Ala Ala Ala Val Pro Leu Ile Leu Glu Gln 
        195                 200                 205             


Leu Met Ala Leu Gln Gln Gln Gln Ile His Gln Leu Gln Leu Ile Glu 
    210                 215                 220                 


Gln Ile Arg Ser Gln Val Ala Leu Met Gln Arg Pro Pro Pro Arg Pro 
225                 230                 235                 240 


Ser Leu Ser Pro Ala Ala Ala Pro Ser Ala Pro Gly Pro Ala Pro Ser 
                245                 250                 255     


Gln Leu Pro Gly Leu Ala Ala Leu Pro Leu Ser Ala Gly Ala Pro Ala 
            260                 265                 270         


Ala Ala Ile Ala Gly Ser Gly Pro Ala Ala Pro Ala Ala Phe Glu Gly 
        275                 280                 285             


Ala Gln Pro Leu Ser Arg Pro Glu Ser Gly Ala Ser Thr Pro Gly Gly 
    290                 295                 300                 


Pro Ala Glu Pro Ser Ala Pro Ala Ala Pro Ser Ala Ala Pro Ala Pro 
305                 310                 315                 320 


Ala Ala Pro Ala Pro Ala Pro Ala Pro Gln Ser Ala Ala Ser Ser Gln 
                325                 330                 335     


Pro Gln Ser Ala Ser Thr Pro Pro Ala Leu Ala Pro Gly Ser Leu Leu 
            340                 345                 350         


Gly Ala Ala Pro Gly Leu Pro Ser Pro Leu Leu Pro Gln Thr Ser Ala 
        355                 360                 365             


Ser Gly Val Ile Phe Pro Asn Pro Leu Val Ser Ile Ala Ala Thr Ala 
    370                 375                 380                 


Asn Ala Leu Asp Pro Leu Ser Ala Leu Met Lys His Arg Lys Gly Lys 
385                 390                 395                 400 


Pro Pro Asn Val Ser Val Phe Glu Pro Lys Ala Ser Ala Glu Asp Pro 
                405                 410                 415     


Phe Phe Lys His Lys Cys Arg Phe Cys Ala Lys Val Phe Gly Ser Asp 
            420                 425                 430         


Ser Ala Leu Gln Ile His Leu Arg Ser His Thr Gly Glu Arg Pro Phe 
        435                 440                 445             


Lys Cys Asn Ile Cys Gly Asn Arg Phe Ser Thr Lys Gly Asn Leu Lys 
    450                 455                 460                 


Val His Phe Gln Arg His Lys Glu Lys Tyr Pro His Ile Gln Met Asn 
465                 470                 475                 480 


Pro Tyr Pro Val Pro Glu Tyr Leu Asp Asn Val Pro Thr Cys Ser Gly 
                485                 490                 495     


Ile Pro Tyr Gly Met Ser Leu Pro Pro Glu Lys Pro Val Thr Thr Trp 
            500                 505                 510         


Leu Asp Ser Lys Pro Val Leu Pro Thr Val Pro Thr Ser Val Gly Leu 
        515                 520                 525             


Gln Leu Pro Pro Thr Val Pro Gly Ala His Gly Tyr Ala Asp Ser Pro 
    530                 535                 540                 


Ser Ala Thr Pro Ala Ser Arg Ser Pro Gln Arg Pro Ser Pro Ala Ser 
545                 550                 555                 560 


Ser Glu Cys Ala Ser Leu Ser Pro Gly Leu Asn His Val Glu Ser Gly 
                565                 570                 575     


Val Ser Ala Thr Ala Glu Ser Pro Gln Ser Leu Leu Gly Gly Pro Pro 
            580                 585                 590         


Leu Thr Lys Ala Glu Pro Val Ser Leu Pro Cys Thr Asn Ala Arg Ala 
        595                 600                 605             


Gly Asp Ala Pro Val Gly Ala Gln Ala Ser Ala Ala Pro Thr Ser Val 
    610                 615                 620                 


Asp Gly Ala Pro Thr Ser Leu Gly Ser Pro Gly Leu Pro Ala Val Ser 
625                 630                 635                 640 


Glu Gln Phe Lys Ala Gln Phe Pro Phe Gly Gly Leu Leu Asp Ser Met 
                645                 650                 655     


Gln Thr Ser Glu Thr Ser Lys Leu Gln Gln Leu Val Glu Asn Ile Asp 
            660                 665                 670         


Lys Lys Met Thr Asp Pro Asn Gln Cys Val Ile Cys His Arg Val Leu 
        675                 680                 685             


Ser Cys Gln Ser Ala Leu Lys Met His Tyr Arg Thr His Thr Gly Glu 
    690                 695                 700                 


Arg Pro Phe Lys Cys Lys Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly 
705                 710                 715                 720 


Asn Leu Lys Thr His Phe Gly Val His Arg Ala Lys Pro Pro Leu Arg 
                725                 730                 735     


Val Gln His Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val 
            740                 745                 750         


Val Leu Gln Gln His Ile Arg Met His Met Gly Gly Gln Ile Pro Asn 
        755                 760                 765             


Thr Pro Leu Pro Glu Gly Phe Gln Asp Ala Met Asp Ser Glu Leu Ala 
    770                 775                 780                 


Tyr Asp Asp Lys Asn Ala Glu Thr Leu Ser Ser Tyr Asp Asp Asp Met 
785                 790                 795                 800 


Asp Glu Asn Ser Met Glu Asp Asp Ala Glu Leu Lys Asp Ala Ala Thr 
                805                 810                 815     


Asp Pro Ala Lys Pro Leu Leu Ser Tyr Ala Gly Ser Cys Pro Pro Ser 
            820                 825                 830         


Pro Pro Ser Val Ile Ser Ser Ile Ala Ala Leu Glu Asn Gln Met Lys 
        835                 840                 845             


Met Ile Asp Ser Val Met Ser Cys Gln Gln Leu Thr Gly Leu Lys Ser 
    850                 855                 860                 


Val Glu Asn Gly Ser Gly Glu Ser Asp Arg Leu Ser Asn Asp Ser Ser 
865                 870                 875                 880 


Ser Ala Val Gly Asp Leu Glu Ser Arg Ser Ala Gly Ser Pro Ala Leu 
                885                 890                 895     


Ser Glu Ser Ser Ser Ser Gln Ala Leu Ser Pro Ala Pro Ser Asn Gly 
            900                 905                 910         


Glu Ser Phe Arg Ser Lys Ser Pro Gly Leu Gly Ala Pro Glu Glu Pro 
        915                 920                 925             


Gln Glu Ile Pro Leu Lys Thr Glu Arg Pro Asp Ser Pro Ala Ala Ala 
    930                 935                 940                 


Pro Gly Ser Gly Gly Ala Pro Gly Arg Ala Gly Ile Lys Glu Glu Ala 
945                 950                 955                 960 


Pro Phe Ser Leu Leu Phe Leu Ser Arg Glu Arg Gly Lys Cys Pro Ser 
                965                 970                 975     


Thr Val Cys Gly Val Cys Gly Lys Pro Phe Ala Cys Lys Ser Ala Leu 
            980                 985                 990         


Glu Ile His Tyr Arg Ser His Thr  Lys Glu Arg Pro Phe  Val Cys Ala 
        995                 1000                 1005             


Leu Cys  Arg Arg Gly Cys Ser  Thr Met Gly Asn Leu  Lys Gln His 
    1010                 1015                 1020             


Leu Leu  Thr His Arg Leu Lys  Glu Leu Pro Ser Gln  Leu Phe Asp 
    1025                 1030                 1035             


Pro Asn  Phe Ala Leu Gly Pro  Ser Gln Ser Thr Pro  Ser Leu Ile 
    1040                 1045                 1050             


Ser Ser  Ala Ala Pro Thr Met  Ile Lys Met Glu Val  Asn Gly His 
    1055                 1060                 1065             


Gly Lys  Ala Met Ala Leu Gly  Glu Gly Pro Pro Leu  Pro Ala Gly 
    1070                 1075                 1080             


Val Gln  Val Pro Ala Gly Pro  Gln Thr Val Met Gly  Pro Gly Leu 
    1085                 1090                 1095             


Ala Pro  Met Leu Ala Pro Pro  Pro Arg Arg Thr Pro  Lys Gln His 
    1100                 1105                 1110             


Asn Cys  Gln Ser Cys Gly Lys  Thr Phe Ser Ser Ala  Ser Ala Leu 
    1115                 1120                 1125             


Gln Ile  His Glu Arg Thr His  Thr Gly Glu Lys Pro  Phe Gly Cys 
    1130                 1135                 1140             


Thr Ile  Cys Gly Arg Ala Phe  Thr Thr Lys Gly Asn  Leu Lys Val 
    1145                 1150                 1155             


His Met  Gly Thr His Met Trp  Asn Asn Ala Pro Ala  Arg Arg Gly 
    1160                 1165                 1170             


Arg Arg  Leu Ser Val Glu Asn  Pro Met Ala Leu Leu  Gly Gly Asp 
    1175                 1180                 1185             


Ala Leu  Lys Phe Ser Glu Met  Phe Gln Lys Asp Leu  Ala Ala Arg 
    1190                 1195                 1200             


Ala Met  Asn Val Asp Pro Ser  Phe Trp Asn Gln Tyr  Ala Ala Ala 
    1205                 1210                 1215             


Ile Thr  Asn Gly Leu Ala Met  Lys Asn Asn Glu Ile  Ser Val Ile 
    1220                 1225                 1230             


Gln Asn  Gly Gly Ile Pro Gln  Leu Pro Val Ser Leu  Gly Gly Ser 
    1235                 1240                 1245             


Ala Leu  Pro Pro Leu Gly Ser  Met Ala Ser Gly Met  Asp Lys Ala 
    1250                 1255                 1260             


Arg Thr  Gly Ser Ser Pro Pro  Ile Val Ser Leu Asp  Lys Ala Ser 
    1265                 1270                 1275             


Ser Glu  Thr Ala Ala Ser Arg  Pro Phe Thr Arg Phe  Ile Glu Asp 
    1280                 1285                 1290             


Asn Lys  Glu Ile Gly Ile Asn  
    1295                 1300 


<210>  11
<211>  1053
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Ile Asn Ser Glu Glu 
1               5                   10                  15      


Asp Gln Gly Glu Gln Gln Pro Gln Gln Gln Thr Pro Glu Phe Ala Asp 
            20                  25                  30          


Ala Ala Pro Ala Ala Pro Ala Ala Gly Glu Leu Gly Ala Pro Val Asn 
        35                  40                  45              


His Pro Gly Asn Asp Glu Val Ala Ser Glu Asp Glu Ala Thr Val Lys 
    50                  55                  60                  


Arg Leu Arg Arg Glu Glu Thr His Val Cys Glu Lys Cys Cys Ala Glu 
65                  70                  75                  80  


Phe Phe Ser Ile Ser Glu Phe Leu Glu His Lys Lys Asn Cys Thr Lys 
                85                  90                  95      


Asn Pro Pro Val Leu Ile Met Asn Asp Ser Glu Gly Pro Val Pro Ser 
            100                 105                 110         


Glu Asp Phe Ser Gly Ala Val Leu Ser His Gln Pro Thr Ser Pro Gly 
        115                 120                 125             


Ser Lys Asp Cys His Arg Glu Asn Gly Gly Ser Ser Glu Asp Met Lys 
    130                 135                 140                 


Glu Lys Pro Asp Ala Glu Ser Val Val Tyr Leu Lys Thr Glu Thr Ala 
145                 150                 155                 160 


Leu Pro Pro Thr Pro Gln Asp Ile Ser Tyr Leu Ala Lys Gly Lys Val 
                165                 170                 175     


Ala Asn Thr Asn Val Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala 
            180                 185                 190         


Val Asn Gln Arg Ser Ala Asp Ala Leu Pro Ala Pro Val Pro Gly Ala 
        195                 200                 205             


Asn Ser Ile Pro Trp Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln 
    210                 215                 220                 


Gln Leu Gln Gln Ile Gln Leu Thr Glu Gln Ile Arg Ile Gln Val Asn 
225                 230                 235                 240 


Met Trp Ala Ser His Ala Leu His Ser Ser Gly Ala Gly Ala Asp Thr 
                245                 250                 255     


Leu Lys Thr Leu Gly Ser His Met Ser Gln Gln Val Ser Ala Ala Val 
            260                 265                 270         


Ala Leu Leu Ser Gln Lys Ala Gly Ser Gln Gly Leu Ser Leu Asp Ala 
        275                 280                 285             


Leu Lys Gln Ala Lys Leu Pro His Ala Asn Ile Pro Ser Ala Thr Ser 
    290                 295                 300                 


Ser Leu Ser Pro Gly Leu Ala Pro Phe Thr Leu Lys Pro Asp Gly Thr 
305                 310                 315                 320 


Arg Val Leu Pro Asn Val Met Ser Arg Leu Pro Ser Ala Leu Leu Pro 
                325                 330                 335     


Gln Ala Pro Gly Ser Val Leu Phe Gln Ser Pro Phe Ser Thr Val Ala 
            340                 345                 350         


Leu Asp Thr Ser Lys Lys Gly Lys Gly Lys Pro Pro Asn Ile Ser Ala 
        355                 360                 365             


Val Asp Val Lys Pro Lys Asp Glu Ala Ala Leu Tyr Lys His Lys Cys 
    370                 375                 380                 


Lys Tyr Cys Ser Lys Val Phe Gly Thr Asp Ser Ser Leu Gln Ile His 
385                 390                 395                 400 


Leu Arg Ser His Thr Gly Glu Arg Pro Phe Val Cys Ser Val Cys Gly 
                405                 410                 415     


His Arg Phe Thr Thr Lys Gly Asn Leu Lys Val His Phe His Arg His 
            420                 425                 430         


Pro Gln Val Lys Ala Asn Pro Gln Leu Phe Ala Glu Phe Gln Asp Lys 
        435                 440                 445             


Val Ala Ala Gly Asn Gly Ile Pro Tyr Ala Leu Ser Val Pro Asp Pro 
    450                 455                 460                 


Ile Asp Glu Pro Ser Leu Ser Leu Asp Ser Lys Pro Val Leu Val Thr 
465                 470                 475                 480 


Thr Ser Val Gly Leu Pro Gln Asn Leu Ser Ser Gly Thr Asn Pro Lys 
                485                 490                 495     


Asp Leu Thr Gly Gly Ser Leu Pro Gly Asp Leu Gln Pro Gly Pro Ser 
            500                 505                 510         


Pro Glu Ser Glu Gly Gly Pro Thr Leu Pro Gly Val Gly Pro Asn Tyr 
        515                 520                 525             


Asn Ser Pro Arg Ala Gly Gly Phe Gln Gly Ser Gly Thr Pro Glu Pro 
    530                 535                 540                 


Gly Ser Glu Thr Leu Lys Leu Gln Gln Leu Val Glu Asn Ile Asp Lys 
545                 550                 555                 560 


Ala Thr Thr Asp Pro Asn Glu Cys Leu Ile Cys His Arg Val Leu Ser 
                565                 570                 575     


Cys Gln Ser Ser Leu Lys Met His Tyr Arg Thr His Thr Gly Glu Arg 
            580                 585                 590         


Pro Phe Gln Cys Lys Ile Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn 
        595                 600                 605             


Leu Lys Thr His Leu Gly Val His Arg Thr Asn Thr Ser Ile Lys Thr 
    610                 615                 620                 


Gln His Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Met 
625                 630                 635                 640 


Leu Gln Gln His Ile Arg Met His Met Gly Gly Gln Ile Pro Asn Thr 
                645                 650                 655     


Pro Leu Pro Glu Asn Pro Cys Asp Phe Thr Gly Ser Glu Pro Met Thr 
            660                 665                 670         


Val Gly Glu Asn Gly Ser Thr Gly Ala Ile Cys His Asp Asp Val Ile 
        675                 680                 685             


Glu Ser Ile Asp Val Glu Glu Val Ser Ser Gln Glu Ala Pro Ser Ser 
    690                 695                 700                 


Ser Ser Lys Val Pro Thr Pro Leu Pro Ser Ile His Ser Ala Ser Pro 
705                 710                 715                 720 


Thr Leu Gly Phe Ala Met Met Ala Ser Leu Asp Ala Pro Gly Lys Val 
                725                 730                 735     


Gly Pro Ala Pro Phe Asn Leu Gln Arg Gln Gly Ser Arg Glu Asn Gly 
            740                 745                 750         


Ser Val Glu Ser Asp Gly Leu Thr Asn Asp Ser Ser Ser Leu Met Gly 
        755                 760                 765             


Asp Gln Glu Tyr Gln Ser Arg Ser Pro Asp Ile Leu Glu Thr Thr Ser 
    770                 775                 780                 


Phe Gln Ala Leu Ser Pro Ala Asn Ser Gln Ala Glu Ser Ile Lys Ser 
785                 790                 795                 800 


Lys Ser Pro Asp Ala Gly Ser Lys Ala Glu Ser Ser Glu Asn Ser Arg 
                805                 810                 815     


Thr Glu Met Glu Gly Arg Ser Ser Leu Pro Ser Thr Phe Ile Arg Ala 
            820                 825                 830         


Pro Pro Thr Tyr Val Lys Val Glu Val Pro Gly Thr Phe Val Gly Pro 
        835                 840                 845             


Ser Thr Leu Ser Pro Gly Met Thr Pro Leu Leu Ala Ala Gln Pro Arg 
    850                 855                 860                 


Arg Gln Ala Lys Gln His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser 
865                 870                 875                 880 


Ser Ala Ser Ala Leu Gln Ile His Glu Arg Thr His Thr Gly Glu Lys 
                885                 890                 895     


Pro Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn 
            900                 905                 910         


Leu Lys Val His Tyr Met Thr His Gly Ala Asn Asn Asn Ser Ala Arg 
        915                 920                 925             


Arg Gly Arg Lys Leu Ala Ile Glu Asn Thr Met Ala Leu Leu Gly Thr 
    930                 935                 940                 


Asp Gly Lys Arg Val Ser Glu Ile Phe Pro Lys Glu Ile Leu Ala Pro 
945                 950                 955                 960 


Ser Val Asn Val Asp Pro Val Val Trp Asn Gln Tyr Thr Ser Met Leu 
                965                 970                 975     


Asn Gly Gly Leu Ala Val Lys Thr Asn Glu Ile Ser Val Ile Gln Ser 
            980                 985                 990         


Gly Gly Val Pro Thr Leu Pro Val  Ser Leu Gly Ala Thr  Ser Val Val 
        995                 1000                 1005             


Asn Asn  Ala Thr Val Ser Lys  Met Asp Gly Ser Gln  Ser Gly Ile 
    1010                 1015                 1020             


Ser Ala  Asp Val Glu Lys Pro  Ser Ala Thr Asp Gly  Val Pro Lys 
    1025                 1030                 1035             


His Gln  Phe Pro His Phe Leu  Glu Glu Asn Lys Ile  Ala Val Ser 
    1040                 1045                 1050             


<210>  12
<211>  616
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (141)..(141)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (442)..(442)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (444)..(445)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (456)..(456)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (602)..(602)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (613)..(613)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Ile Asn Ser Glu Glu 
1               5                   10                  15      


Asp Gln Gly Glu Gln Gln Pro Gln Gln Gln Thr Pro Glu Phe Ala Asp 
            20                  25                  30          


Ala Ala Pro Ala Ala Pro Ala Ala Gly Glu Leu Gly Ala Pro Val Asn 
        35                  40                  45              


His Pro Gly Asn Asp Glu Val Ala Ser Glu Asp Glu Ala Thr Val Lys 
    50                  55                  60                  


Arg Leu Arg Arg Glu Glu Thr His Val Cys Glu Lys Cys Cys Ala Glu 
65                  70                  75                  80  


Phe Phe Ser Ile Ser Glu Phe Leu Glu His Lys Lys Asn Cys Thr Lys 
                85                  90                  95      


Asn Pro Pro Val Leu Ile Met Asn Asp Ser Glu Gly Pro Val Pro Ser 
            100                 105                 110         


Xaa Asp Phe Ser Gly Ala Val Leu Ser His Gln Pro Thr Ser Pro Gly 
        115                 120                 125             


Ser Glu Asp Cys His Arg Glu Asn Gly Gly Ser Ser Xaa Asp Ile Lys 
    130                 135                 140                 


Glu Lys Pro Asp Ala Glu Ser Val Val Tyr Leu Lys Thr Glu Thr Ala 
145                 150                 155                 160 


Leu Pro Pro Thr Pro Gln Asp Ile Ser Tyr Leu Ala Lys Gly Lys Val 
                165                 170                 175     


Ala Asn Thr Asn Val Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala 
            180                 185                 190         


Val Asn Gln Arg Ser Ala Asp Ala Leu Pro Ala Pro Val Pro Gly Ala 
        195                 200                 205             


Asn Ser Ile Pro Trp Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln 
    210                 215                 220                 


Gln Leu Gln Gln Ile Gln Leu Thr Glu Gln Ile Arg Ile Gln Val Asn 
225                 230                 235                 240 


Met Trp Ala Ser His Ala Leu His Ser Ser Gly Ala Gly Ala Asp Thr 
                245                 250                 255     


Leu Lys Thr Leu Gly Ser His Met Ser Gln Gln Val Ser Ala Ala Val 
            260                 265                 270         


Ala Leu Leu Ser Gln Lys Ala Gly Ser Gln Gly Leu Ser Leu Asp Ala 
        275                 280                 285             


Leu Lys Gln Ala Lys Leu Pro His Ala Asn Ile Pro Ser Ala Thr Ser 
    290                 295                 300                 


Ser Leu Ser Pro Gly Leu Ala Pro Phe Thr Leu Lys Pro Asp Gly Thr 
305                 310                 315                 320 


Arg Val Leu Pro Asn Val Met Ser Arg Leu Pro Ser Ala Leu Leu Pro 
                325                 330                 335     


Gln Ala Pro Gly Ser Val Leu Phe Gln Ser Pro Phe Ser Thr Val Ala 
            340                 345                 350         


Leu Asp Thr Ser Lys Lys Gly Lys Gly Lys Pro Pro Asn Ile Ser Ala 
        355                 360                 365             


Val Asp Val Lys Pro Lys Asp Glu Ala Ala Leu Tyr Lys His Lys Cys 
    370                 375                 380                 


Arg Ser Ser Leu Pro Ser Thr Phe Ile Arg Ala Pro Pro Thr Tyr Val 
385                 390                 395                 400 


Lys Val Glu Val Pro Gly Thr Phe Val Gly Pro Ser Thr Leu Ser Pro 
                405                 410                 415     


Gly Met Thr Pro Leu Leu Ala Ala Gln Pro Arg Gly Gln Ala Lys Gln 
            420                 425                 430         


His Gly Cys Thr Arg Cys Gly Lys Asn Xaa Ser Xaa Xaa Ser Ala Leu 
        435                 440                 445             


Gln Ile His Glu Arg Thr His Xaa Gly Glu Lys Pro Phe Val Cys Asn 
    450                 455                 460                 


Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn Leu Lys Val His Tyr 
465                 470                 475                 480 


Met Thr His Gly Ala Asn Asn Asn Ser Ala Arg Arg Gly Arg Lys Leu 
                485                 490                 495     


Ala Ile Glu Asn Thr Met Ala Leu Leu Gly Thr Asp Gly Lys Arg Val 
            500                 505                 510         


Ser Glu Ile Phe Pro Lys Glu Ile Leu Ala Pro Ser Val Asn Val Asp 
        515                 520                 525             


Pro Val Val Trp Asn Gln Tyr Thr Ser Met Leu Asn Gly Gly Leu Ala 
    530                 535                 540                 


Val Lys Thr Asn Glu Ile Ser Val Ile Gln Ser Gly Gly Val Pro Thr 
545                 550                 555                 560 


Leu Pro Val Ser Leu Gly Ala Thr Ser Val Val Asn Asn Ala Thr Val 
                565                 570                 575     


Ser Lys Met Asp Gly Ser Gln Ser Gly Ile Ser Ala Asp Val Glu Lys 
            580                 585                 590         


Pro Ser Ala Thr Asp Gly Val Pro Lys Xaa Gln Phe Pro His Phe Leu 
        595                 600                 605             


Glu Glu Asn Lys Xaa Ala Val Ser 
    610                 615     


