                         SEQUENCE LISTING

<110>  Pantarhei Bioscience B.V.
 
<120>  Immunotherapeutic method for treating prostate cancer 
       

<130>  P6032277EP

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  638
<212>  PRT
<213>  human

<400>  1

Met Ala Gly Gly Ser Ala Thr Thr Trp Gly Tyr Pro Val Ala Leu Leu 
1               5                   10                  15      

Leu Leu Val Ala Thr Leu Gly Leu Gly Arg Trp Leu Gln Pro Asp Pro 
            20                  25                  30          

Gly Leu Pro Gly Leu Arg His Ser Tyr Asp Cys Gly Ile Lys Gly Met 
        35                  40                  45              

Gln Leu Leu Val Phe Pro Arg Pro Gly Gln Thr Leu Arg Phe Lys Val 
    50                  55                  60                  

Val Asp Glu Phe Gly Asn Arg Phe Asp Val Asn Asn Cys Ser Ile Cys 
65                  70                  75                  80  

Tyr His Trp Val Thr Ser Arg Pro Gln Glu Pro Ala Val Phe Ser Ala 
                85                  90                  95      

Asp Tyr Arg Gly Cys His Val Leu Glu Lys Asp Gly Arg Phe His Leu 
            100                 105                 110         

Arg Val Phe Met Glu Ala Val Leu Pro Asn Gly Arg Val Asp Val Ala 
        115                 120                 125             

Gln Asp Ala Thr Leu Ile Cys Pro Lys Pro Asp Pro Ser Arg Thr Leu 
    130                 135                 140                 

Asp Ser Gln Leu Ala Pro Pro Ala Met Phe Ser Val Ser Thr Pro Gln 
145                 150                 155                 160 

Thr Leu Ser Phe Leu Pro Thr Ser Gly His Thr Ser Gln Gly Ser Gly 
                165                 170                 175     

His Ala Phe Pro Ser Pro Leu Asp Pro Gly His Ser Ser Val His Pro 
            180                 185                 190         

Thr Pro Ala Leu Pro Ser Pro Gly Pro Gly Pro Thr Leu Ala Thr Leu 
        195                 200                 205             

Ala Gln Pro His Trp Gly Thr Leu Glu His Trp Asp Val Asn Lys Arg 
    210                 215                 220                 

Asp Tyr Ile Gly Thr His Leu Ser Gln Glu Gln Cys Gln Val Ala Ser 
225                 230                 235                 240 

Gly His Leu Pro Cys Ile Val Arg Arg Thr Ser Lys Glu Ala Cys Gln 
                245                 250                 255     

Gln Ala Gly Cys Cys Tyr Asp Asn Thr Arg Glu Val Pro Cys Tyr Tyr 
            260                 265                 270         

Gly Asn Thr Ala Thr Val Gln Cys Phe Arg Asp Gly Tyr Phe Val Leu 
        275                 280                 285             

Val Val Ser Gln Glu Met Ala Leu Thr His Arg Ile Thr Leu Ala Asn 
    290                 295                 300                 

Ile His Leu Ala Tyr Ala Pro Thr Ser Cys Ser Pro Thr Gln His Thr 
305                 310                 315                 320 

Glu Ala Phe Val Val Phe Tyr Phe Pro Leu Thr His Cys Gly Thr Thr 
                325                 330                 335     

Met Gln Val Ala Gly Asp Gln Leu Ile Tyr Glu Asn Trp Leu Val Ser 
            340                 345                 350         

Gly Ile His Ile Gln Lys Gly Pro Gln Gly Ser Ile Thr Arg Asp Ser 
        355                 360                 365             

Thr Phe Gln Leu His Val Arg Cys Val Phe Asn Ala Ser Asp Phe Leu 
    370                 375                 380                 

Pro Ile Gln Ala Ser Ile Phe Pro Pro Pro Ser Pro Ala Pro Met Thr 
385                 390                 395                 400 

Gln Pro Gly Pro Leu Arg Leu Glu Leu Arg Ile Ala Lys Asp Glu Thr 
                405                 410                 415     

Phe Ser Ser Tyr Tyr Gly Glu Asp Asp Tyr Pro Ile Val Arg Leu Leu 
            420                 425                 430         

Arg Glu Pro Val His Val Glu Val Arg Leu Leu Gln Arg Thr Asp Pro 
        435                 440                 445             

Asn Leu Val Leu Leu Leu His Gln Cys Trp Gly Ala Pro Ser Ala Asn 
    450                 455                 460                 

Pro Phe Gln Gln Pro Gln Trp Pro Ile Leu Ser Asp Gly Cys Pro Phe 
465                 470                 475                 480 

Lys Gly Asp Ser Tyr Arg Thr Gln Met Val Ala Leu Asp Gly Ala Thr 
                485                 490                 495     

Pro Phe Gln Ser His Tyr Gln Arg Phe Thr Val Ala Thr Phe Ala Leu 
            500                 505                 510         

Leu Asp Ser Gly Ser Gln Arg Ala Leu Arg Gly Leu Val Tyr Leu Phe 
        515                 520                 525             

Cys Ser Thr Ser Ala Cys His Thr Ser Gly Leu Glu Thr Cys Ser Thr 
    530                 535                 540                 

Ala Cys Ser Thr Gly Thr Thr Arg Gln Arg Arg Ser Ser Gly His Arg 
545                 550                 555                 560 

Asn Asp Thr Ala Arg Pro Gln Asp Ile Val Ser Ser Pro Gly Pro Val 
                565                 570                 575     

Gly Phe Glu Asp Ser Tyr Gly Gln Glu Pro Thr Leu Gly Pro Thr Asp 
            580                 585                 590         

Ser Asn Gly Asn Ser Ser Leu Arg Pro Leu Leu Trp Ala Val Leu Leu 
        595                 600                 605             

Leu Pro Ala Val Ala Leu Val Leu Gly Phe Gly Val Phe Val Gly Leu 
    610                 615                 620                 

Ser Gln Thr Trp Ala Gln Lys Leu Trp Glu Ser Asn Arg Gln 
625                 630                 635             


<210>  2
<211>  745
<212>  PRT
<213>  human

<400>  2

Met Ala Cys Arg Gln Arg Gly Gly Ser Trp Ser Pro Ser Gly Trp Phe 
1               5                   10                  15      

Asn Ala Gly Trp Ser Thr Tyr Arg Ser Ile Ser Leu Phe Phe Ala Leu 
            20                  25                  30          

Val Thr Ser Gly Asn Ser Ile Asp Val Ser Gln Leu Val Asn Pro Ala 
        35                  40                  45              

Phe Pro Gly Thr Val Thr Cys Asp Glu Arg Glu Ile Thr Val Glu Phe 
    50                  55                  60                  

Pro Ser Ser Pro Gly Thr Lys Lys Trp His Ala Ser Val Val Asp Pro 
65                  70                  75                  80  

Leu Gly Leu Asp Met Pro Asn Cys Thr Tyr Ile Leu Asp Pro Glu Lys 
                85                  90                  95      

Leu Thr Leu Arg Ala Thr Tyr Asp Asn Cys Thr Arg Arg Val His Gly 
            100                 105                 110         

Gly His Gln Met Thr Ile Arg Val Met Asn Asn Ser Ala Ala Leu Arg 
        115                 120                 125             

His Gly Ala Val Met Tyr Gln Phe Phe Cys Pro Ala Met Gln Val Glu 
    130                 135                 140                 

Glu Thr Gln Gly Leu Ser Ala Ser Thr Ile Cys Gln Lys Asp Phe Met 
145                 150                 155                 160 

Ser Phe Ser Leu Pro Arg Val Phe Ser Gly Leu Ala Asp Asp Ser Lys 
                165                 170                 175     

Gly Thr Lys Val Gln Met Gly Trp Ser Ile Glu Val Gly Asp Gly Ala 
            180                 185                 190         

Arg Ala Lys Thr Leu Thr Leu Pro Glu Ala Met Lys Glu Gly Phe Ser 
        195                 200                 205             

Leu Leu Ile Asp Asn His Arg Met Thr Phe His Val Pro Phe Asn Ala 
    210                 215                 220                 

Thr Gly Val Thr His Tyr Val Gln Gly Asn Ser His Leu Tyr Met Val 
225                 230                 235                 240 

Ser Leu Lys Leu Thr Phe Ile Ser Pro Gly Gln Lys Val Ile Phe Ser 
                245                 250                 255     

Ser Gln Ala Ile Cys Ala Pro Asp Pro Val Thr Cys Asn Ala Thr His 
            260                 265                 270         

Met Thr Leu Thr Ile Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Ser 
        275                 280                 285             

Phe Glu Asn Gln Asn Ile Asp Val Ser Gln Leu His Asp Asn Gly Ile 
    290                 295                 300                 

Asp Leu Glu Ala Thr Asn Gly Met Lys Leu His Phe Ser Lys Thr Leu 
305                 310                 315                 320 

Leu Lys Thr Lys Leu Ser Glu Lys Cys Leu Leu His Gln Phe Tyr Leu 
                325                 330                 335     

Ala Ser Leu Lys Leu Thr Phe Leu Leu Arg Pro Glu Thr Val Ser Met 
            340                 345                 350         

Val Ile Tyr Pro Glu Cys Leu Cys Glu Ser Pro Val Ser Ile Val Thr 
        355                 360                 365             

Gly Glu Leu Cys Thr Gln Asp Gly Phe Met Asp Val Glu Val Tyr Ser 
    370                 375                 380                 

Tyr Gln Thr Gln Pro Ala Leu Asp Leu Gly Thr Leu Arg Val Gly Asn 
385                 390                 395                 400 

Ser Ser Cys Gln Pro Val Phe Glu Ala Gln Ser Gln Gly Leu Val Arg 
                405                 410                 415     

Phe His Ile Pro Leu Asn Gly Cys Gly Thr Arg Tyr Lys Phe Glu Asp 
            420                 425                 430         

Asp Lys Val Val Tyr Glu Asn Glu Ile His Ala Leu Trp Thr Asp Phe 
        435                 440                 445             

Pro Pro Ser Lys Ile Ser Arg Asp Ser Glu Phe Arg Met Thr Val Lys 
    450                 455                 460                 

Cys Ser Tyr Ser Arg Asn Asp Met Leu Leu Asn Ile Asn Val Glu Ser 
465                 470                 475                 480 

Leu Thr Pro Pro Val Ala Ser Val Lys Leu Gly Pro Phe Thr Leu Ile 
                485                 490                 495     

Leu Gln Ser Tyr Pro Asp Asn Ser Tyr Gln Gln Pro Tyr Gly Glu Asn 
            500                 505                 510         

Glu Tyr Pro Leu Val Arg Phe Leu Arg Gln Pro Ile Tyr Met Glu Val 
        515                 520                 525             

Arg Val Leu Asn Arg Asp Asp Pro Asn Ile Lys Leu Val Leu Asp Asp 
    530                 535                 540                 

Cys Trp Ala Thr Ser Thr Met Asp Pro Asp Ser Phe Pro Gln Trp Asn 
545                 550                 555                 560 

Val Val Val Asp Gly Cys Ala Tyr Asp Leu Asp Asn Tyr Gln Thr Thr 
                565                 570                 575     

Phe His Pro Val Gly Ser Ser Val Thr His Pro Asp His Tyr Gln Arg 
            580                 585                 590         

Phe Asp Met Lys Ala Phe Ala Phe Val Ser Glu Ala His Val Leu Ser 
        595                 600                 605             

Ser Leu Val Tyr Phe His Cys Ser Ala Leu Ile Cys Asn Arg Leu Ser 
    610                 615                 620                 

Pro Asp Ser Pro Leu Cys Ser Val Thr Cys Pro Val Ser Ser Arg His 
625                 630                 635                 640 

Arg Arg Ala Thr Gly Ala Thr Glu Ala Glu Lys Met Thr Val Ser Leu 
                645                 650                 655     

Pro Gly Pro Ile Leu Leu Leu Ser Asp Asp Ser Ser Phe Arg Gly Val 
            660                 665                 670         

Gly Ser Ser Asp Leu Lys Ala Ser Gly Ser Ser Gly Glu Lys Ser Arg 
        675                 680                 685             

Ser Glu Thr Gly Glu Glu Val Gly Ser Arg Gly Ala Met Asp Thr Lys 
    690                 695                 700                 

Gly His Lys Thr Ala Gly Asp Val Gly Ser Lys Ala Val Ala Ala Val 
705                 710                 715                 720 

Ala Ala Phe Ala Gly Val Val Ala Thr Leu Gly Phe Ile Tyr Tyr Leu 
                725                 730                 735     

Tyr Glu Lys Arg Thr Val Ser Asn His 
            740                 745 


<210>  3
<211>  424
<212>  PRT
<213>  human

<400>  3

Met Glu Leu Ser Tyr Arg Leu Phe Ile Cys Leu Leu Leu Trp Gly Ser 
1               5                   10                  15      

Thr Glu Leu Cys Tyr Pro Gln Pro Leu Trp Leu Leu Gln Gly Gly Ala 
            20                  25                  30          

Ser His Pro Glu Thr Ser Val Gln Pro Val Leu Val Glu Cys Gln Glu 
        35                  40                  45              

Ala Thr Leu Met Val Met Val Ser Lys Asp Leu Phe Gly Thr Gly Lys 
    50                  55                  60                  

Leu Ile Arg Ala Ala Asp Leu Thr Leu Gly Pro Glu Ala Cys Glu Pro 
65                  70                  75                  80  

Leu Val Ser Met Asp Thr Glu Asp Val Val Arg Phe Glu Val Gly Leu 
                85                  90                  95      

His Glu Cys Gly Asn Ser Met Gln Val Thr Asp Asp Ala Leu Val Tyr 
            100                 105                 110         

Ser Thr Phe Leu Leu His Asp Pro Arg Pro Val Gly Asn Leu Ser Ile 
        115                 120                 125             

Val Arg Thr Asn Arg Ala Glu Ile Pro Ile Glu Cys Arg Tyr Pro Arg 
    130                 135                 140                 

Gln Gly Asn Val Ser Ser Gln Ala Ile Leu Pro Thr Trp Leu Pro Phe 
145                 150                 155                 160 

Arg Thr Thr Val Phe Ser Glu Glu Lys Leu Thr Phe Ser Leu Arg Leu 
                165                 170                 175     

Met Glu Glu Asn Trp Asn Ala Glu Lys Arg Ser Pro Thr Phe His Leu 
            180                 185                 190         

Gly Asp Ala Ala His Leu Gln Ala Glu Ile His Thr Gly Ser His Val 
        195                 200                 205             

Pro Leu Arg Leu Phe Val Asp His Cys Val Ala Thr Pro Thr Pro Asp 
    210                 215                 220                 

Gln Asn Ala Ser Pro Tyr His Thr Ile Val Asp Phe His Gly Cys Leu 
225                 230                 235                 240 

Val Asp Gly Leu Thr Asp Ala Ser Ser Ala Phe Lys Val Pro Arg Pro 
                245                 250                 255     

Gly Pro Asp Thr Leu Gln Phe Thr Val Asp Val Phe His Phe Ala Asn 
            260                 265                 270         

Asp Ser Arg Asn Met Ile Tyr Ile Thr Cys His Leu Lys Val Thr Leu 
        275                 280                 285             

Ala Glu Gln Asp Pro Asp Glu Leu Asn Lys Ala Cys Ser Phe Ser Lys 
    290                 295                 300                 

Pro Ser Asn Ser Trp Phe Pro Val Glu Gly Pro Ala Asp Ile Cys Gln 
305                 310                 315                 320 

Cys Cys Asn Lys Gly Asp Cys Gly Thr Pro Ser His Ser Arg Arg Gln 
                325                 330                 335     

Pro His Val Met Ser Gln Trp Ser Arg Ser Ala Ser Arg Asn Arg Arg 
            340                 345                 350         

His Val Thr Glu Glu Ala Asp Val Thr Val Gly Pro Leu Ile Phe Leu 
        355                 360                 365             

Asp Arg Arg Gly Asp His Glu Val Glu Gln Trp Ala Leu Pro Ser Asp 
    370                 375                 380                 

Thr Ser Val Val Leu Leu Gly Val Gly Leu Ala Val Val Val Ser Leu 
385                 390                 395                 400 

Thr Leu Thr Ala Val Ile Leu Val Leu Thr Arg Arg Cys Arg Thr Ala 
                405                 410                 415     

Ser His Pro Val Ser Ala Ser Glu 
            420                 


<210>  4
<211>  540
<212>  PRT
<213>  human

<400>  4

Met Trp Leu Leu Arg Cys Val Leu Leu Cys Val Ser Leu Ser Leu Ala 
1               5                   10                  15      

Val Ser Gly Gln His Lys Pro Glu Ala Pro Asp Tyr Ser Ser Val Leu 
            20                  25                  30          

His Cys Gly Pro Trp Ser Phe Gln Phe Ala Val Asn Leu Asn Gln Glu 
        35                  40                  45              

Ala Thr Ser Pro Pro Val Leu Ile Ala Trp Asp Asn Gln Gly Leu Leu 
    50                  55                  60                  

His Glu Leu Gln Asn Asp Ser Asp Cys Gly Thr Trp Ile Arg Lys Gly 
65                  70                  75                  80  

Pro Gly Ser Ser Val Val Leu Glu Ala Thr Tyr Ser Ser Cys Tyr Val 
                85                  90                  95      

Thr Glu Trp Asp Ser His Tyr Ile Met Pro Val Gly Val Glu Gly Ala 
            100                 105                 110         

Gly Ala Ala Glu His Lys Val Val Thr Glu Arg Lys Leu Leu Lys Cys 
        115                 120                 125             

Pro Met Asp Leu Leu Ala Arg Asp Ala Pro Asp Thr Asp Trp Cys Asp 
    130                 135                 140                 

Ser Ile Pro Ala Arg Asp Arg Leu Pro Cys Ala Pro Ser Pro Ile Ser 
145                 150                 155                 160 

Arg Gly Asp Cys Glu Gly Leu Gly Cys Cys Tyr Ser Ser Glu Glu Val 
                165                 170                 175     

Asn Ser Cys Tyr Tyr Gly Asn Thr Val Thr Leu His Cys Thr Arg Glu 
            180                 185                 190         

Gly His Phe Ser Ile Ala Val Ser Arg Asn Val Thr Ser Pro Pro Leu 
        195                 200                 205             

Leu Leu Asp Ser Val Arg Leu Ala Leu Arg Asn Asp Ser Ala Cys Asn 
    210                 215                 220                 

Pro Val Met Ala Thr Gln Ala Phe Val Leu Phe Gln Phe Pro Phe Thr 
225                 230                 235                 240 

Ser Cys Gly Thr Thr Arg Gln Ile Thr Gly Asp Arg Ala Val Tyr Glu 
                245                 250                 255     

Asn Glu Leu Val Ala Thr Arg Asp Val Lys Asn Gly Ser Arg Gly Ser 
            260                 265                 270         

Val Thr Arg Asp Ser Ile Phe Arg Leu His Val Ser Cys Ser Tyr Ser 
        275                 280                 285             

Val Ser Ser Asn Ser Leu Pro Ile Asn Val Gln Val Phe Thr Leu Pro 
    290                 295                 300                 

Pro Pro Phe Pro Glu Thr Gln Pro Gly Pro Leu Thr Leu Glu Leu Gln 
305                 310                 315                 320 

Ile Ala Lys Asp Lys Asn Tyr Gly Ser Tyr Tyr Gly Val Gly Asp Tyr 
                325                 330                 335     

Pro Val Val Lys Leu Leu Arg Asp Pro Ile Tyr Val Glu Val Ser Ile 
            340                 345                 350         

Leu His Arg Thr Asp Pro Tyr Leu Gly Leu Leu Leu Gln Gln Cys Trp 
        355                 360                 365             

Ala Thr Pro Ser Thr Asp Pro Leu Ser Gln Pro Gln Trp Pro Ile Leu 
    370                 375                 380                 

Val Lys Gly Cys Pro Tyr Ile Gly Asp Asn Tyr Gln Thr Gln Leu Ile 
385                 390                 395                 400 

Pro Val Gln Lys Ala Leu Asp Leu Pro Phe Pro Ser His His Gln Arg 
                405                 410                 415     

Phe Ser Ile Phe Thr Phe Ser Phe Val Asn Pro Thr Val Glu Lys Gln 
            420                 425                 430         

Ala Leu Arg Gly Pro Val His Leu His Cys Ser Val Ser Val Cys Gln 
        435                 440                 445             

Pro Ala Glu Thr Pro Ser Cys Val Val Thr Cys Pro Asp Leu Ser Arg 
    450                 455                 460                 

Arg Arg Asn Phe Asp Asn Ser Ser Gln Asn Thr Thr Ala Ser Val Ser 
465                 470                 475                 480 

Ser Lys Gly Pro Met Ile Leu Leu Gln Ala Thr Lys Asp Pro Pro Glu 
                485                 490                 495     

Lys Leu Arg Val Pro Val Asp Ser Lys Val Leu Trp Val Ala Gly Leu 
            500                 505                 510         

Ser Gly Thr Leu Ile Leu Gly Ala Leu Leu Val Ser Tyr Leu Ala Val 
        515                 520                 525             

Lys Lys Gln Lys Ser Cys Pro Asp Gln Met Cys Gln 
    530                 535                 540 


