                         SEQUENCE LISTING

<110>  ISIS INNOVATION LIMITED
 
<120>  METHOD

<130>  N.111752B

<150>  GB 1014285.9
<151>  2010-08-26


<150>  GB 1106785.7
<151>  2011-04-20

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  1953
<212>  RNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (82)..(1110)

<400>  1
gcagaccuug cuucaugagc aagcucaucu cuggaacaaa cuggcaaagc aucucugcug       60

guguucauca gaacagacac c aug gca gag cau gau uac cau gaa gac uau        111
                        Met Ala Glu His Asp Tyr His Glu Asp Tyr           
                        1               5                   10            

ggg uuc agc agu uuc aau gac agc agc cag gag gag cau caa gac uuc        159
Gly Phe Ser Ser Phe Asn Asp Ser Ser Gln Glu Glu His Gln Asp Phe           
                15                  20                  25                

cug cag uuc agc aag guc uuu cug ccc ugc aug uac cug gug gug uuu        207
Leu Gln Phe Ser Lys Val Phe Leu Pro Cys Met Tyr Leu Val Val Phe           
            30                  35                  40                    

guc ugu ggu cug gug ggg aac ucu cug gug cug guc aua ucc auc uuc        255
Val Cys Gly Leu Val Gly Asn Ser Leu Val Leu Val Ile Ser Ile Phe           
        45                  50                  55                        

uac cau aag uug cag agc cug acg gau gug uuc cug gug aac cua ccc        303
Tyr His Lys Leu Gln Ser Leu Thr Asp Val Phe Leu Val Asn Leu Pro           
    60                  65                  70                            

cug gcu gac cug gug uuu guc ugc acu cug ccc uuc ugg gcc uau gca        351
Leu Ala Asp Leu Val Phe Val Cys Thr Leu Pro Phe Trp Ala Tyr Ala           
75                  80                  85                  90            

ggc auc cau gaa ugg gug uuu ggc cag guc aug ugc aag agc cua cug        399
Gly Ile His Glu Trp Val Phe Gly Gln Val Met Cys Lys Ser Leu Leu           
                95                  100                 105               

ggc auc uac acu auu aac uuc uac acg ucc aug cuc auc cuc acc ugc        447
Gly Ile Tyr Thr Ile Asn Phe Tyr Thr Ser Met Leu Ile Leu Thr Cys           
            110                 115                 120                   

auc acu gug gau cgu uuc auu gua gug guu aag gcc acc aag gcc uac        495
Ile Thr Val Asp Arg Phe Ile Val Val Val Lys Ala Thr Lys Ala Tyr           
        125                 130                 135                       

aac cag caa gcc aag agg aug acc ugg ggc aag guc acc agc uug cuc        543
Asn Gln Gln Ala Lys Arg Met Thr Trp Gly Lys Val Thr Ser Leu Leu           
    140                 145                 150                           

auc ugg gug aua ucc cug cug guu ucc uug ccc caa auu auc uau ggc        591
Ile Trp Val Ile Ser Leu Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly           
155                 160                 165                 170           

aau guc uuu aau cuc gac aag cuc aua ugu ggu uac cau gac gag gca        639
Asn Val Phe Asn Leu Asp Lys Leu Ile Cys Gly Tyr His Asp Glu Ala           
                175                 180                 185               

auu ucc acu gug guu cuu gcc acc cag aug aca cug ggg uuc uuc uug        687
Ile Ser Thr Val Val Leu Ala Thr Gln Met Thr Leu Gly Phe Phe Leu           
            190                 195                 200                   

cca cug cuc acc aug auu guc ugc uau uca guc aua auc aaa aca cug        735
Pro Leu Leu Thr Met Ile Val Cys Tyr Ser Val Ile Ile Lys Thr Leu           
        205                 210                 215                       

cuu cau gcu gga ggc uuc cag aag cac aga ucu cua aag auc auc uuc        783
Leu His Ala Gly Gly Phe Gln Lys His Arg Ser Leu Lys Ile Ile Phe           
    220                 225                 230                           

cug gug aug gcu gug uuc cug cug acc cag aug ccc uuc aac cuc aug        831
Leu Val Met Ala Val Phe Leu Leu Thr Gln Met Pro Phe Asn Leu Met           
235                 240                 245                 250           

aag uuc auc cgc agc aca cac ugg gaa uac uau gcc aug acc agc uuu        879
Lys Phe Ile Arg Ser Thr His Trp Glu Tyr Tyr Ala Met Thr Ser Phe           
                255                 260                 265               

cac uac acc auc aug gug aca gag gcc auc gca uac cug agg gcc ugc        927
His Tyr Thr Ile Met Val Thr Glu Ala Ile Ala Tyr Leu Arg Ala Cys           
            270                 275                 280                   

cuu aac ccu gug cuc uau gcc uuu guc agc cug aag uuu cga aag aac        975
Leu Asn Pro Val Leu Tyr Ala Phe Val Ser Leu Lys Phe Arg Lys Asn           
        285                 290                 295                       

uuc ugg aaa cuu gug aag gac auu ggu ugc cuc ccu uac cuu ggg guc       1023
Phe Trp Lys Leu Val Lys Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val           
    300                 305                 310                           

uca cau caa ugg aaa ucu ucu gag gac aau ucc aag acu uuu ucu gcc       1071
Ser His Gln Trp Lys Ser Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala           
315                 320                 325                 330           

ucc cac aau gug gag gcc acc agc aug uuc cag uua uag gccuugccag        1120
Ser His Asn Val Glu Ala Thr Ser Met Phe Gln Leu                           
                335                 340                                   

gguuucgaga agcugcucug gaauuugcaa gucauggcug ugcccucuug auguggugag     1180

gcaggcuuug uuuauagcuu gcgcauucuc auggagaagu uaucagacac ucuggcuggu     1240

uuggaaugcu ucuucucagg caugaacaug uacuguucuc uucuugaaca cucaugcuga     1300

aagcccaagu agggggucua aaauuuuuaa ggacuuuccu uccuccaucu ccaagaaugc     1360

ugaaaccaag ggggaugaca ugugacuccu augaucucag guucuccuug auugggacug     1420

gggcugaagg uugaagaggu gagcacggcc aacaaagcug uugaugguag guggcacacu     1480

gggugcccaa gcucagaagg cucuucugac uacugggcaa agaguguaga ucagagcagc     1540

agugaaaaca agugcuggca ccaccaggca ccucacagaa augagaucag gcucugccuc     1600

accuuggggc uugacuuuug uauagguaga uguucagauu gcuuugauua auccagaaua     1660

acuagcacca gggacuauga augggcaaaa cugaauuaua agaggcugau aauuccagug     1720

guccauggaa ugcuugaaaa augugcaaaa cagcguuuaa gacuguaaug aaucuaagca     1780

gcauuucuga aguggacucu uugguggcuu ugcauuuuaa aaaugaaauu uuccaauguc     1840

ugccacacaa acguauguaa auguauauac ccacacacau acacacauau gucauauauu     1900

acuagcauau gaguuucaua gcuaagaaau aaaacuguua aagucuccaa acu            1953


<210>  2
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


Phe Leu Pro Cys Met Tyr Leu Val Val Phe Val Cys Gly Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Val Ile Ser Ile Phe Tyr His Lys Leu Gln Ser 
    50                  55                  60                  


Leu Thr Asp Val Phe Leu Val Asn Leu Pro Leu Ala Asp Leu Val Phe 
65                  70                  75                  80  


Val Cys Thr Leu Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val 
                85                  90                  95      


Phe Gly Gln Val Met Cys Lys Ser Leu Leu Gly Ile Tyr Thr Ile Asn 
            100                 105                 110         


Phe Tyr Thr Ser Met Leu Ile Leu Thr Cys Ile Thr Val Asp Arg Phe 
        115                 120                 125             


Ile Val Val Val Lys Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg 
    130                 135                 140                 


Met Thr Trp Gly Lys Val Thr Ser Leu Leu Ile Trp Val Ile Ser Leu 
145                 150                 155                 160 


Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Phe Asn Leu Asp 
                165                 170                 175     


Lys Leu Ile Cys Gly Tyr His Asp Glu Ala Ile Ser Thr Val Val Leu 
            180                 185                 190         


Ala Thr Gln Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Thr Met Ile 
        195                 200                 205             


Val Cys Tyr Ser Val Ile Ile Lys Thr Leu Leu His Ala Gly Gly Phe 
    210                 215                 220                 


Gln Lys His Arg Ser Leu Lys Ile Ile Phe Leu Val Met Ala Val Phe 
225                 230                 235                 240 


Leu Leu Thr Gln Met Pro Phe Asn Leu Met Lys Phe Ile Arg Ser Thr 
                245                 250                 255     


His Trp Glu Tyr Tyr Ala Met Thr Ser Phe His Tyr Thr Ile Met Val 
            260                 265                 270         


Thr Glu Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr 
        275                 280                 285             


Ala Phe Val Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys 
    290                 295                 300                 


Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys Ser 
305                 310                 315                 320 


Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala Ser His Asn Val Glu Ala 
                325                 330                 335     


Thr Ser Met Phe Gln Leu 
            340         


<210>  3
<211>  1893
<212>  RNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (75)..(1130)

<400>  3
agagaaccag aggcagaccu uuagugagca cacuucacuc uggaacaaag cuacugggcu       60

ucucuucuga ugcc aug gau gau ggg cau caa gag uca gcu cug uac gau        110
                Met Asp Asp Gly His Gln Glu Ser Ala Leu Tyr Asp           
                1               5                   10                    

ggg cac uac gag gga gau uuc ugg cuc uuc aac aau ucc agu gau aac        158
Gly His Tyr Glu Gly Asp Phe Trp Leu Phe Asn Asn Ser Ser Asp Asn           
        15                  20                  25                        

agc cag gag aac aaa cgc uuc cua aag uuc aag gag guc uuu uug ccc        206
Ser Gln Glu Asn Lys Arg Phe Leu Lys Phe Lys Glu Val Phe Leu Pro           
    30                  35                  40                            

ugu gug uac cug gua gug uuu guc uuu gga cug cua gga aac ucc cug        254
Cys Val Tyr Leu Val Val Phe Val Phe Gly Leu Leu Gly Asn Ser Leu           
45                  50                  55                  60            

guu cug auu aua uac auu uuc uac cag aag cug agg acu cug aca gau        302
Val Leu Ile Ile Tyr Ile Phe Tyr Gln Lys Leu Arg Thr Leu Thr Asp           
                65                  70                  75                

gug uuu cug cug aac uug ccc cug gcu gac cug gug uuu guc ugu acu        350
Val Phe Leu Leu Asn Leu Pro Leu Ala Asp Leu Val Phe Val Cys Thr           
            80                  85                  90                    

cug ccc uuu ugg gcc uau gca ggc acc uau gag ugg guc uuu ggc aca        398
Leu Pro Phe Trp Ala Tyr Ala Gly Thr Tyr Glu Trp Val Phe Gly Thr           
        95                  100                 105                       

guc aug ugc aaa acu cuu cga ggc aug uau aca aug aac uuc uac gug        446
Val Met Cys Lys Thr Leu Arg Gly Met Tyr Thr Met Asn Phe Tyr Val           
    110                 115                 120                           

ucc aug cuc acu cuc acc ugc auc aca gug gau cgu uuc auu gua gug        494
Ser Met Leu Thr Leu Thr Cys Ile Thr Val Asp Arg Phe Ile Val Val           
125                 130                 135                 140           

guc cag gcu acc aag gcc uuc aac cgg cag gcu aag ugg aag auc ugg        542
Val Gln Ala Thr Lys Ala Phe Asn Arg Gln Ala Lys Trp Lys Ile Trp           
                145                 150                 155               

ggc caa guc auu ugc uug cuc auu ugg gug guc ucc cug uug guu ucu        590
Gly Gln Val Ile Cys Leu Leu Ile Trp Val Val Ser Leu Leu Val Ser           
            160                 165                 170                   

uug cca cag auc auc uau ggc cau guu caa gau auu gac aag cuu auc        638
Leu Pro Gln Ile Ile Tyr Gly His Val Gln Asp Ile Asp Lys Leu Ile           
        175                 180                 185                       

ugu cag uac cac agu gag gag aua ucc acu aug guu cuu guu aua cag        686
Cys Gln Tyr His Ser Glu Glu Ile Ser Thr Met Val Leu Val Ile Gln           
    190                 195                 200                           

aug acu cug ggg uuc uuc cug cca uug cuc acu aug auu cug ugc uac        734
Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Thr Met Ile Leu Cys Tyr           
205                 210                 215                 220           

uca ggc auu auc aag acc uug cuu cau gcu cga aac uuc cag aag cac        782
Ser Gly Ile Ile Lys Thr Leu Leu His Ala Arg Asn Phe Gln Lys His           
                225                 230                 235               

aaa ucu cua aag auc auc uuc cuu gua gug gcu gug uuc cug cug acc        830
Lys Ser Leu Lys Ile Ile Phe Leu Val Val Ala Val Phe Leu Leu Thr           
            240                 245                 250                   

cag aca ccc uuc aac cuu gcc aug uua auc caa agu aca agc ugg gag        878
Gln Thr Pro Phe Asn Leu Ala Met Leu Ile Gln Ser Thr Ser Trp Glu           
        255                 260                 265                       

uac uau acc aua acc agc uuu aag uau gcc auc gua gug aca gag gcu        926
Tyr Tyr Thr Ile Thr Ser Phe Lys Tyr Ala Ile Val Val Thr Glu Ala           
    270                 275                 280                           

aua gca uac uuu cgg gcu ugc cuu aac ccu gua cuu uau gcc uuu guu        974
Ile Ala Tyr Phe Arg Ala Cys Leu Asn Pro Val Leu Tyr Ala Phe Val           
285                 290                 295                 300           

ggc uua aag uuc cgg aag aac guc ugg aaa cuu aug aag gau auc ggc       1022
Gly Leu Lys Phe Arg Lys Asn Val Trp Lys Leu Met Lys Asp Ile Gly           
                305                 310                 315               

ugc cuc ucu cac cug gga guc uca agu caa ugg aag ucu ucu gag gac       1070
Cys Leu Ser His Leu Gly Val Ser Ser Gln Trp Lys Ser Ser Glu Asp           
            320                 325                 330                   

agu ucc aag acu ugu ucu gcc ucc cac aau gua gag acc acc agu aug       1118
Ser Ser Lys Thr Cys Ser Ala Ser His Asn Val Glu Thr Thr Ser Met           
        335                 340                 345                       

uuc caa uug uag uaggccuugc cacacuuaga gaaguuaaua acagaauucu           1170
Phe Gln Leu                                                               
    350                                                                   

aggagcaugg cuguaucauu uggaugcaac aagaaaagcu uugcuuauag cauguggagu     1230

aucauggaga agucacugaa caccauggcu gguacacaaa acuucucaga uauaaauaua     1290

cccuauucuu aauaucuaag ccuaaugcuc aaaggagaau gaguaucuug agauuuugaa     1350

gcacuuucuc ucuuucaucc ucaagaaugc ugaaaucaag gucaugacgg uuaacucuag     1410

agaucucaag uucucuuuuu accaaguuug ggccuaaaag uugaagagcu gcaucaacaa     1470

agauguugcu ggcagauaau guucagggcu cuugaguuca gaagauucuu cagugggcaa     1530

gcaguugaga auugaaaagg cuccauacaa augcugcuug aaugagacca gguucugacu     1590

cauccagggg ucugucugac uuuuguaugg guggaugcuu auguuuuacu ggaauugucu     1650

uguaaagugc agcaauaugg gacugaaaac aggccagaau aaauaagcug aauuucagug     1710

guccauguaa ugcuagaaaa auguauaaaa cagagcuuaa gacuuuaaca aauacaagag     1770

gacucuggug gcuuugcuca ucuaaaaaaa aaaaaugaaa gaaauuguga cacauacuau     1830

guacacacaa auauaucaag cauuuugagu uucauggcua agaaauaaaa ccuuuuaaau     1890

guu                                                                   1893


<210>  4
<211>  351
<212>  PRT
<213>  Mus musculus

<400>  4

Met Asp Asp Gly His Gln Glu Ser Ala Leu Tyr Asp Gly His Tyr Glu 
1               5                   10                  15      


Gly Asp Phe Trp Leu Phe Asn Asn Ser Ser Asp Asn Ser Gln Glu Asn 
            20                  25                  30          


Lys Arg Phe Leu Lys Phe Lys Glu Val Phe Leu Pro Cys Val Tyr Leu 
        35                  40                  45              


Val Val Phe Val Phe Gly Leu Leu Gly Asn Ser Leu Val Leu Ile Ile 
    50                  55                  60                  


Tyr Ile Phe Tyr Gln Lys Leu Arg Thr Leu Thr Asp Val Phe Leu Leu 
65                  70                  75                  80  


Asn Leu Pro Leu Ala Asp Leu Val Phe Val Cys Thr Leu Pro Phe Trp 
                85                  90                  95      


Ala Tyr Ala Gly Thr Tyr Glu Trp Val Phe Gly Thr Val Met Cys Lys 
            100                 105                 110         


Thr Leu Arg Gly Met Tyr Thr Met Asn Phe Tyr Val Ser Met Leu Thr 
        115                 120                 125             


Leu Thr Cys Ile Thr Val Asp Arg Phe Ile Val Val Val Gln Ala Thr 
    130                 135                 140                 


Lys Ala Phe Asn Arg Gln Ala Lys Trp Lys Ile Trp Gly Gln Val Ile 
145                 150                 155                 160 


Cys Leu Leu Ile Trp Val Val Ser Leu Leu Val Ser Leu Pro Gln Ile 
                165                 170                 175     


Ile Tyr Gly His Val Gln Asp Ile Asp Lys Leu Ile Cys Gln Tyr His 
            180                 185                 190         


Ser Glu Glu Ile Ser Thr Met Val Leu Val Ile Gln Met Thr Leu Gly 
        195                 200                 205             


Phe Phe Leu Pro Leu Leu Thr Met Ile Leu Cys Tyr Ser Gly Ile Ile 
    210                 215                 220                 


Lys Thr Leu Leu His Ala Arg Asn Phe Gln Lys His Lys Ser Leu Lys 
225                 230                 235                 240 


Ile Ile Phe Leu Val Val Ala Val Phe Leu Leu Thr Gln Thr Pro Phe 
                245                 250                 255     


Asn Leu Ala Met Leu Ile Gln Ser Thr Ser Trp Glu Tyr Tyr Thr Ile 
            260                 265                 270         


Thr Ser Phe Lys Tyr Ala Ile Val Val Thr Glu Ala Ile Ala Tyr Phe 
        275                 280                 285             


Arg Ala Cys Leu Asn Pro Val Leu Tyr Ala Phe Val Gly Leu Lys Phe 
    290                 295                 300                 


Arg Lys Asn Val Trp Lys Leu Met Lys Asp Ile Gly Cys Leu Ser His 
305                 310                 315                 320 


Leu Gly Val Ser Ser Gln Trp Lys Ser Ser Glu Asp Ser Ser Lys Thr 
                325                 330                 335     


Cys Ser Ala Ser His Asn Val Glu Thr Thr Ser Met Phe Gln Leu 
            340                 345                 350     


<210>  5
<211>  1955
<212>  RNA
<213>  Bos taurus


<220>
<221>  CDS
<222>  (108)..(1130)

<400>  5
aaccuggacc acaucagaga caacggcaga ccuugcugcu gugagcaacc ucgucugauc       60

aacaaacuga aagagcagcu cuaccggggu ccagcagaac agacgac aug gcu gag        116
                                                    Met Ala Glu           
                                                    1                     

uac aac uac gaa gac cuc ggg uuc uuc aau ggu ucc aac gac agc agc        164
Tyr Asn Tyr Glu Asp Leu Gly Phe Phe Asn Gly Ser Asn Asp Ser Ser           
    5                   10                  15                            

cag ggg cac caa gac uuc cug cgg uuc agc aag uuc uuc cug ccg ugc        212
Gln Gly His Gln Asp Phe Leu Arg Phe Ser Lys Phe Phe Leu Pro Cys           
20                  25                  30                  35            

aug uac gug gug gug uuc acc ugc ggc cug gug gga aac ucc uug gug        260
Met Tyr Val Val Val Phe Thr Cys Gly Leu Val Gly Asn Ser Leu Val           
                40                  45                  50                

cug guc auc uac guc uuc uac cag aag cug aag agc cug aca gac gug        308
Leu Val Ile Tyr Val Phe Tyr Gln Lys Leu Lys Ser Leu Thr Asp Val           
            55                  60                  65                    

uuc cug aug aac cug ccc cug gcu gac cug gug uuc guc ugc acu cug        356
Phe Leu Met Asn Leu Pro Leu Ala Asp Leu Val Phe Val Cys Thr Leu           
        70                  75                  80                        

ccc uuc ugg gcc uac gca ggc auc cau gag ugg guc uuu ggc aac guc        404
Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val Phe Gly Asn Val           
    85                  90                  95                            

aug ugc aaa gcc cug cug ggc auc uac acg cug aac uuc uac acg ucc        452
Met Cys Lys Ala Leu Leu Gly Ile Tyr Thr Leu Asn Phe Tyr Thr Ser           
100                 105                 110                 115           

aug cuc gug cuc acc ugc auc acc gug gac cgc uuc guc gcg gug gug        500
Met Leu Val Leu Thr Cys Ile Thr Val Asp Arg Phe Val Ala Val Val           
                120                 125                 130               

cgg gcc acc aag gcc uac aac cag cag gcc aag cgc aug gcc ugg ggu        548
Arg Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg Met Ala Trp Gly           
            135                 140                 145                   

aag gcc auc ugc ucg ucc auc ugg gug guu ucc cug cug guu ucc uug        596
Lys Ala Ile Cys Ser Ser Ile Trp Val Val Ser Leu Leu Val Ser Leu           
        150                 155                 160                       

ccg cag auc auc uau ggc aac guc cuu uac cac gac aag ccc uuc ugc        644
Pro Gln Ile Ile Tyr Gly Asn Val Leu Tyr His Asp Lys Pro Phe Cys           
    165                 170                 175                           

ggu uau cac gag gcg auu ucc acc aug gug cug gcc auc cag aug acc        692
Gly Tyr His Glu Ala Ile Ser Thr Met Val Leu Ala Ile Gln Met Thr           
180                 185                 190                 195           

cug ggg uuc uuu cug cca cug cuu gcc aug auc cuc ugc uac ucg guc        740
Leu Gly Phe Phe Leu Pro Leu Leu Ala Met Ile Leu Cys Tyr Ser Val           
                200                 205                 210               

auc auc aag acc cug cuu cag gcu cga ggc uuc cgg aag cac aag ucu        788
Ile Ile Lys Thr Leu Leu Gln Ala Arg Gly Phe Arg Lys His Lys Ser           
            215                 220                 225                   

cug aag auc auc uuc cug gug gug gcg gug uuc cug cug acc cag acg        836
Leu Lys Ile Ile Phe Leu Val Val Ala Val Phe Leu Leu Thr Gln Thr           
        230                 235                 240                       

ccc uuc aac cuc gug aag cuc auc cgc agc aca agc ugg gag uac cac        884
Pro Phe Asn Leu Val Lys Leu Ile Arg Ser Thr Ser Trp Glu Tyr His           
    245                 250                 255                           

acc aug acc agc uuu gac uac gcc auc acg gug acg gag gcc auu gcc        932
Thr Met Thr Ser Phe Asp Tyr Ala Ile Thr Val Thr Glu Ala Ile Ala           
260                 265                 270                 275           

uac cug cgu gcc ugc cuu aau ccu gug cuc uau gcc uuu guu ggc cuc        980
Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr Ala Phe Val Gly Leu           
                280                 285                 290               

aag uuu cgg aag aau uuc ugg aag cuc gug aaa gac gca ggc ugc cuc       1028
Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys Asp Ala Gly Cys Leu           
            295                 300                 305                   

ccu uac cug ggu guc uca ggc caa cac aug uau ucc gag gac acu ucc       1076
Pro Tyr Leu Gly Val Ser Gly Gln His Met Tyr Ser Glu Asp Thr Ser           
        310                 315                 320                       

agg agu gcu uca gcg ucu cac aac gug gag gcc acc agc aug uuc cac       1124
Arg Ser Ala Ser Ala Ser His Asn Val Glu Ala Thr Ser Met Phe His           
    325                 330                 335                           

cug uag ggcucgggga ggcucccgga ugucauggga gcacagcugu gucuuccaga        1180
Leu                                                                       
340                                                                       

ugaggcaggc uuuguguaua gcgcaugcgu ucucacggag agguuaccca acgccgcagc     1240

uggggugggc ugcugcuucu caggcaugaa cagaucugcu uuuucacagc cuagccuaag     1300

cucaaagggg agucugaaag cugcccgggc uuuccuuccu ccaccccaac aauacugaug     1360

ccaggaaaug acaugugauu cucaagaccc cagguucucc uucacugaga augggacugg     1420

gacagaguug augaggggga cauggccaac aaagguuuug aaggcaggua agagucuggu     1480

uuccaaguuc caaacacuuu ucugacggcu gguaagcagg ggacauuaga gcagccauga     1540

aaaccagugc ugaucuuggu gucuuagacc uucaucacca ggugccugac agaaaugagu     1600

ucagguucug ucacaucuuu cguuucguuu uuauagagau agaugguuaa uccugcuauc     1660

uuugcuugac ccuggaagga cuagcaccag gaaacacgaa ugggcugaag caaaacaggg     1720

uuggcugaag auuccagugg gccacagaag gcuagaaaag ugugcaaagc ugggugcaga     1780

cugucaggag ucuaagcagc acuucugaaa uggauccuca guggguuugc ucuuaaaauc     1840

ugaauuauuc aaugccucac auacaaauca uguauaaaug uguguguuau acacauacau     1900

gcauaucaga uagcauauga uuuuuaugac ugagaaauaa aacuuuuaaa auguc          1955


<210>  6
<211>  340
<212>  PRT
<213>  Bos taurus

<400>  6

Met Ala Glu Tyr Asn Tyr Glu Asp Leu Gly Phe Phe Asn Gly Ser Asn 
1               5                   10                  15      


Asp Ser Ser Gln Gly His Gln Asp Phe Leu Arg Phe Ser Lys Phe Phe 
            20                  25                  30          


Leu Pro Cys Met Tyr Val Val Val Phe Thr Cys Gly Leu Val Gly Asn 
        35                  40                  45              


Ser Leu Val Leu Val Ile Tyr Val Phe Tyr Gln Lys Leu Lys Ser Leu 
    50                  55                  60                  


Thr Asp Val Phe Leu Met Asn Leu Pro Leu Ala Asp Leu Val Phe Val 
65                  70                  75                  80  


Cys Thr Leu Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val Phe 
                85                  90                  95      


Gly Asn Val Met Cys Lys Ala Leu Leu Gly Ile Tyr Thr Leu Asn Phe 
            100                 105                 110         


Tyr Thr Ser Met Leu Val Leu Thr Cys Ile Thr Val Asp Arg Phe Val 
        115                 120                 125             


Ala Val Val Arg Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg Met 
    130                 135                 140                 


Ala Trp Gly Lys Ala Ile Cys Ser Ser Ile Trp Val Val Ser Leu Leu 
145                 150                 155                 160 


Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Leu Tyr His Asp Lys 
                165                 170                 175     


Pro Phe Cys Gly Tyr His Glu Ala Ile Ser Thr Met Val Leu Ala Ile 
            180                 185                 190         


Gln Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Ala Met Ile Leu Cys 
        195                 200                 205             


Tyr Ser Val Ile Ile Lys Thr Leu Leu Gln Ala Arg Gly Phe Arg Lys 
    210                 215                 220                 


His Lys Ser Leu Lys Ile Ile Phe Leu Val Val Ala Val Phe Leu Leu 
225                 230                 235                 240 


Thr Gln Thr Pro Phe Asn Leu Val Lys Leu Ile Arg Ser Thr Ser Trp 
                245                 250                 255     


Glu Tyr His Thr Met Thr Ser Phe Asp Tyr Ala Ile Thr Val Thr Glu 
            260                 265                 270         


Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr Ala Phe 
        275                 280                 285             


Val Gly Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys Asp Ala 
    290                 295                 300                 


Gly Cys Leu Pro Tyr Leu Gly Val Ser Gly Gln His Met Tyr Ser Glu 
305                 310                 315                 320 


Asp Thr Ser Arg Ser Ala Ser Ala Ser His Asn Val Glu Ala Thr Ser 
                325                 330                 335     


Met Phe His Leu 
            340 


<210>  7
<211>  2344
<212>  RNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (533)..(1354)

<400>  7
ggugcguccg cggguggcug ccccgcaggu gcgcgcggcc ggggcuggcg gcgacucucu       60

ccaccgggcc gcccgggagg cucaugcagc gcggcugggu cccgcggcgc ccggaucggg      120

gaagugaaag ugccucggag gaggagggcc gguccggcag ugcagccgcc ucacaggucg      180

gcggacgggc caggcgggcg gccuccugaa ccgaaccgaa ucggcuccuc gggccgucgu      240

ccucccgccc cuccucgccc gccgccggag uuuucuuucg guuucuucca agauuccugg      300

ccuucccucg acggagccgg gcccagugcg ggggcgcagg gcgcgggagc uccaccuccu      360

cggcuuuccc ugcguccaga ggcuggcaug gcgcgggccg aguacugagc gcacggucgg      420

ggcacagcag ggccgggggg ugcagcuggc ucgcgccucc ucuccggccg ccgucuccuc      480

cgguccccgg cgaaagccau ugagacacca gcuggacguc acgcgccgga gc aug ucu      538
                                                          Met Ser         
                                                          1               

ggg agu cag agc gag gug gcu cca ucc ccg cag agu ccg cgg agc ccc        586
Gly Ser Gln Ser Glu Val Ala Pro Ser Pro Gln Ser Pro Arg Ser Pro           
        5                   10                  15                        

gag aug gga cgg gac uug cgg ccc ggg ucc cgc gug cuc cug cuc cug        634
Glu Met Gly Arg Asp Leu Arg Pro Gly Ser Arg Val Leu Leu Leu Leu           
    20                  25                  30                            

cuu cug cuc cug cug gug uac cug acu cag cca ggc aau ggc aac gag        682
Leu Leu Leu Leu Leu Val Tyr Leu Thr Gln Pro Gly Asn Gly Asn Glu           
35                  40                  45                  50            

ggc agc guc acu gga agu ugu uau ugu ggu aaa aga auu ucu ucc gac        730
Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser Ser Asp           
                55                  60                  65                

ucc ccg cca ucg guu cag uuc aug aau cgu cuc cgg aaa cac cug aga        778
Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His Leu Arg           
            70                  75                  80                    

gcu uac cau cgg ugu cua uac uac acg agg uuc cag cuc cuu ucc ugg        826
Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu Ser Trp           
        85                  90                  95                        

agc gug ugu ggg ggc aac aag gac cca ugg guu cag gaa uug aug agc        874
Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu Met Ser           
    100                 105                 110                           

ugu cuu gau cuc aaa gaa ugu gga cau gcu uac ucg ggg auu gug gcc        922
Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile Val Ala           
115                 120                 125                 130           

cac cag aag cau uua cuu ccu acc agc ccc cca auu ucu cag gcc uca        970
His Gln Lys His Leu Leu Pro Thr Ser Pro Pro Ile Ser Gln Ala Ser           
                135                 140                 145               

gag ggg gca ucu uca gau auc cac acc ccu gcc cag aug cuc cug ucc       1018
Glu Gly Ala Ser Ser Asp Ile His Thr Pro Ala Gln Met Leu Leu Ser           
            150                 155                 160                   

acc uug cag ucc acu cag cgc ccc acc cuc cca gua gga uca cug ucc       1066
Thr Leu Gln Ser Thr Gln Arg Pro Thr Leu Pro Val Gly Ser Leu Ser           
        165                 170                 175                       

ucg gac aaa gag cuc acu cgu ccc aau gaa acc acc auu cac acu gcg       1114
Ser Asp Lys Glu Leu Thr Arg Pro Asn Glu Thr Thr Ile His Thr Ala           
    180                 185                 190                           

ggc cac agu cug gca gcu ggg ccu gag gcu ggg gag aac cag aag cag       1162
Gly His Ser Leu Ala Ala Gly Pro Glu Ala Gly Glu Asn Gln Lys Gln           
195                 200                 205                 210           

ccg gaa aaa aau gcu ggu ccc aca gcc agg aca uca gcc aca gug cca       1210
Pro Glu Lys Asn Ala Gly Pro Thr Ala Arg Thr Ser Ala Thr Val Pro           
                215                 220                 225               

guc cug ugc cuc cug gcc auc auc uuc auc cuc acc gca gcc cuu ucc       1258
Val Leu Cys Leu Leu Ala Ile Ile Phe Ile Leu Thr Ala Ala Leu Ser           
            230                 235                 240                   

uau gug cug ugc aag agg agg agg ggg cag uca ccg cag ucc ucu cca       1306
Tyr Val Leu Cys Lys Arg Arg Arg Gly Gln Ser Pro Gln Ser Ser Pro           
        245                 250                 255                       

gau cug ccg guu cau uau aua ccu gug gca ccu gac ucu aau acc uga       1354
Asp Leu Pro Val His Tyr Ile Pro Val Ala Pro Asp Ser Asn Thr               
    260                 265                 270                           

gccaagaaug gaagcuugug aggagacgga cucuauguug cccaggcugu uauggaacuc     1414

cugagucaag ugauccuccc accuuggccu cugaaggugc gaggauuaua ggcgucaccu     1474

accacaucca gccuacacgu auuuguuaau aucuaacaua ggacuaacca gccacugccc     1534

ucucuuaggc cccucauuua aaaacgguua uacuauaaaa ucugcuuuuc acacugggug     1594

auaauaacuu ggacaaauuc uauguguauu uuguuuuguu uugcuuugcu uuguuuugag     1654

acggagucuc gcucugucau ccaggcugga gugcaguggc augaucucgg cucacugcaa     1714

cccccaucuc ccagguucaa gcgauucucc ugccuccucc ugaguagcug ggacuacagg     1774

ugcucaccac cacacccggc uaauuuuuug uauuuuuagu agagacgggg uuucaccaug     1834

uugaccaggc uggucucgaa cuccugaccu ggugaucugc ccacccaggc cucccaaagu     1894

gcugggauua aaggugugag ccaccaugcc uggcccuaug uguguuuuuu aacuacuaaa     1954

aauuauuuuu guaaugauug agucuucuuu auggaaacaa cuggccucag cccuugcgcc     2014

cuuacuguga uuccuggcuu cauuuuuugc ugaugguucc cccucguccc aaaucucucu     2074

cccaguacac caguuguucc ucccccaccu cagcccucuc cugcauccuc cuguacccgc     2134

aacgaaggcc ugggcuuucc cacccucccu ccuuagcagg ugccgugcug ggacaccaua     2194

cggguugguu ucaccuccuc agucccuugc cuaccccagu gagagucuga ucuuguuuuu     2254

auuguuauug cuuuuauuau uauugcuuuu auuaucauua aaacucuagu ucuuguuuug     2314

ucucuccgaa aaaaaaaaaa aaaaaaaaaa                                      2344


<210>  8
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Gly Ser Gln Ser Glu Val Ala Pro Ser Pro Gln Ser Pro Arg 
1               5                   10                  15      


Ser Pro Glu Met Gly Arg Asp Leu Arg Pro Gly Ser Arg Val Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Val Tyr Leu Thr Gln Pro Gly Asn Gly 
        35                  40                  45              


Asn Glu Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser 
    50                  55                  60                  


Ser Asp Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His 
65                  70                  75                  80  


Leu Arg Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu 
                85                  90                  95      


Ser Trp Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu 
            100                 105                 110         


Met Ser Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile 
        115                 120                 125             


Val Ala His Gln Lys His Leu Leu Pro Thr Ser Pro Pro Ile Ser Gln 
    130                 135                 140                 


Ala Ser Glu Gly Ala Ser Ser Asp Ile His Thr Pro Ala Gln Met Leu 
145                 150                 155                 160 


Leu Ser Thr Leu Gln Ser Thr Gln Arg Pro Thr Leu Pro Val Gly Ser 
                165                 170                 175     


Leu Ser Ser Asp Lys Glu Leu Thr Arg Pro Asn Glu Thr Thr Ile His 
            180                 185                 190         


Thr Ala Gly His Ser Leu Ala Ala Gly Pro Glu Ala Gly Glu Asn Gln 
        195                 200                 205             


Lys Gln Pro Glu Lys Asn Ala Gly Pro Thr Ala Arg Thr Ser Ala Thr 
    210                 215                 220                 


Val Pro Val Leu Cys Leu Leu Ala Ile Ile Phe Ile Leu Thr Ala Ala 
225                 230                 235                 240 


Leu Ser Tyr Val Leu Cys Lys Arg Arg Arg Gly Gln Ser Pro Gln Ser 
                245                 250                 255     


Ser Pro Asp Leu Pro Val His Tyr Ile Pro Val Ala Pro Asp Ser Asn 
            260                 265                 270         


Thr 
    


<210>  9
<211>  1466
<212>  RNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (533)..(1354)

<400>  9
ggugcguccg cggguggcug ccccgcaggu gcgcgcggcc ggggcuggcg gcgacucucu       60

ccaccgggcc gcccgggagg cucaugcagc gcggcugggu cccgcggcgc ccggaucggg      120

gaagugaaag ugccucggag gaggagggcc gguccggcag ugcagccgcc ucacaggucg      180

gcggacgggc caggcgggcg gccuccugaa ccgaaccgaa ucggcuccuc gggccgucgu      240

ccucccgccc cuccucgccc gccgccggag uuuucuuucg guuucuucca agauuccugg      300

ccuucccucg acggagccgg gcccagugcg ggggcgcagg gcgcgggagc uccaccuccu      360

cggcuuuccc ugcguccaga ggcuggcaug gcgcgggccg aguacugagc gcacggucgg      420

ggcacagcag ggccgggggg ugcagcuggc ucgcgccucc ucuccggccg ccgucuccuc      480

cgguccccgg cgaaagccau ugagacacca gcuggacguc acgcgccgga gc aug ucu      538
                                                          Met Ser         
                                                          1               

ggg agu cag agc gag gug gcu cca ucc ccg cag agu ccg cgg agc ccc        586
Gly Ser Gln Ser Glu Val Ala Pro Ser Pro Gln Ser Pro Arg Ser Pro           
        5                   10                  15                        

gag aug gga cgg gac uug cgg ccc ggg ucc cgc gug cuc cug cuc cug        634
Glu Met Gly Arg Asp Leu Arg Pro Gly Ser Arg Val Leu Leu Leu Leu           
    20                  25                  30                            

cuu cug cuc cug cug gug uac cug acu cag cca ggc aau ggc aac gag        682
Leu Leu Leu Leu Leu Val Tyr Leu Thr Gln Pro Gly Asn Gly Asn Glu           
35                  40                  45                  50            

ggc agc guc acu gga agu ugu uau ugu ggu aaa aga auu ucu ucc gac        730
Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser Ser Asp           
                55                  60                  65                

ucc ccg cca ucg guu cag uuc aug aau cgu cuc cgg aaa cac cug aga        778
Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His Leu Arg           
            70                  75                  80                    

gcu uac cau cgg ugu cua uac uac acg agg uuc cag cuc cuu ucc ugg        826
Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu Ser Trp           
        85                  90                  95                        

agc gug ugu ggg ggc aac aag gac cca ugg guu cag gaa uug aug agc        874
Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu Met Ser           
    100                 105                 110                           

ugu cuu gau cuc aaa gaa ugu gga cau gcu uac ucg ggg auu gug gcc        922
Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile Val Ala           
115                 120                 125                 130           

cac cag aag cau uua cuu ccu acc agc ccc cca auu ucu cag gcc uca        970
His Gln Lys His Leu Leu Pro Thr Ser Pro Pro Ile Ser Gln Ala Ser           
                135                 140                 145               

gag ggg gca ucu uca gau auc cac acc ccu gcc cag aug cuc cug ucc       1018
Glu Gly Ala Ser Ser Asp Ile His Thr Pro Ala Gln Met Leu Leu Ser           
            150                 155                 160                   

acc uug cag ucc acu cag cgc ccc acc cuc cca gua gga uca cug ucc       1066
Thr Leu Gln Ser Thr Gln Arg Pro Thr Leu Pro Val Gly Ser Leu Ser           
        165                 170                 175                       

ucg gac aaa gag cuc acu cgu ccc aau gaa acc acc auu cac acu gcg       1114
Ser Asp Lys Glu Leu Thr Arg Pro Asn Glu Thr Thr Ile His Thr Ala           
    180                 185                 190                           

ggc cac agu cug gca gcu ggg ccu gag gcu ggg gag aac cag aag cag       1162
Gly His Ser Leu Ala Ala Gly Pro Glu Ala Gly Glu Asn Gln Lys Gln           
195                 200                 205                 210           

ccg gaa aaa aau gcu ggu ccc aca gcc agg aca uca gcc aca gug cca       1210
Pro Glu Lys Asn Ala Gly Pro Thr Ala Arg Thr Ser Ala Thr Val Pro           
                215                 220                 225               

guc cug ugc cuc cug gcc auc auc uuc auc cuc acc gca gcc cuu ucc       1258
Val Leu Cys Leu Leu Ala Ile Ile Phe Ile Leu Thr Ala Ala Leu Ser           
            230                 235                 240                   

uau gug cug ugc aag agg agg agg ggg cag uca ccg cag ucc ucu cca       1306
Tyr Val Leu Cys Lys Arg Arg Arg Gly Gln Ser Pro Gln Ser Ser Pro           
        245                 250                 255                       

gau cug ccg guu cau uau aua ccu gug gca ccu gac ucu aau acc uga       1354
Asp Leu Pro Val His Tyr Ile Pro Val Ala Pro Asp Ser Asn Thr               
    260                 265                 270                           

gccaagaaug gaagcuugug aggguaaacu guggcuuauu cuuacaaaaa guguaauaaa     1414

ggagacugac cccugacaac augguaggca cuguauaaaa aaaaaaaaaa aa             1466


<210>  10
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Gly Ser Gln Ser Glu Val Ala Pro Ser Pro Gln Ser Pro Arg 
1               5                   10                  15      


Ser Pro Glu Met Gly Arg Asp Leu Arg Pro Gly Ser Arg Val Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Val Tyr Leu Thr Gln Pro Gly Asn Gly 
        35                  40                  45              


Asn Glu Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser 
    50                  55                  60                  


Ser Asp Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His 
65                  70                  75                  80  


Leu Arg Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu 
                85                  90                  95      


Ser Trp Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu 
            100                 105                 110         


Met Ser Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile 
        115                 120                 125             


Val Ala His Gln Lys His Leu Leu Pro Thr Ser Pro Pro Ile Ser Gln 
    130                 135                 140                 


Ala Ser Glu Gly Ala Ser Ser Asp Ile His Thr Pro Ala Gln Met Leu 
145                 150                 155                 160 


Leu Ser Thr Leu Gln Ser Thr Gln Arg Pro Thr Leu Pro Val Gly Ser 
                165                 170                 175     


Leu Ser Ser Asp Lys Glu Leu Thr Arg Pro Asn Glu Thr Thr Ile His 
            180                 185                 190         


Thr Ala Gly His Ser Leu Ala Ala Gly Pro Glu Ala Gly Glu Asn Gln 
        195                 200                 205             


Lys Gln Pro Glu Lys Asn Ala Gly Pro Thr Ala Arg Thr Ser Ala Thr 
    210                 215                 220                 


Val Pro Val Leu Cys Leu Leu Ala Ile Ile Phe Ile Leu Thr Ala Ala 
225                 230                 235                 240 


Leu Ser Tyr Val Leu Cys Lys Arg Arg Arg Gly Gln Ser Pro Gln Ser 
                245                 250                 255     


Ser Pro Asp Leu Pro Val His Tyr Ile Pro Val Ala Pro Asp Ser Asn 
            260                 265                 270         


Thr 
    


<210>  11
<211>  2448
<212>  RNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (538)..(1278)

<400>  11
caugugacug gauccuacug agacccagcg guccagggaa gugaaagcau cuuggagcca       60

gaggaaggau cuagaggguc acccacuuua caaaccagca gacagacaga ugacuucuca      120

agagggcuga aauccccgaa cccaaccgag ucauucuucg ggaaccacag cuugcucacu      180

cggauuccuc ugguucuaca gcccaaauuu ucuuucgguu uugucggaua gucuuggcug      240

acccuacggc uggccggccg gagacuggag cuccgccuuc ggggcagggg uguguguguc      300

ccccgacugg gagcugggcg caaagcgggc uccccgguac cgaccagacg gucgguuccg      360

gacagcgcgc gccgggggac agaaggcgcc accaccucgc gcccccuccc cuccugagcu      420

uggcacggau cagcgccuuc gcaaaacauc agucagggug aagaagagaa agcuuuagag      480

aauuggcugg augucggcua ggugaccucg ucccaacaag cuccgcagaa gccggag         537

aug agg cgg ggc uuu gga ccc uug ucu cuu gcg uuc uuc cuu uuc uug        585
Met Arg Arg Gly Phe Gly Pro Leu Ser Leu Ala Phe Phe Leu Phe Leu           
1               5                   10                  15                

uug gcg cug cug acc cug cca ggc gau ggc aac cag ggc agu guc gcu        633
Leu Ala Leu Leu Thr Leu Pro Gly Asp Gly Asn Gln Gly Ser Val Ala           
            20                  25                  30                    

gga agu ugu ucu ugu gau cgu acc auu ucu ucu ggc acc cag aua ccg        681
Gly Ser Cys Ser Cys Asp Arg Thr Ile Ser Ser Gly Thr Gln Ile Pro           
        35                  40                  45                        

cag ggu acu uug gau cac auc cga aaa uac cug aaa gca uuu cau cgu        729
Gln Gly Thr Leu Asp His Ile Arg Lys Tyr Leu Lys Ala Phe His Arg           
    50                  55                  60                            

ugu cca uuc uuu auc agg uuc cag uug cag ucc aaa agc gug ugu ggg        777
Cys Pro Phe Phe Ile Arg Phe Gln Leu Gln Ser Lys Ser Val Cys Gly           
65                  70                  75                  80            

gga agc caa gac cag ugg guc cgu gaa cua gug gac ugc uuu gag cgc        825
Gly Ser Gln Asp Gln Trp Val Arg Glu Leu Val Asp Cys Phe Glu Arg           
                85                  90                  95                

aaa gag ugu gga acu ggu cau ggg aag agu uuu cac cac caa aaa cau        873
Lys Glu Cys Gly Thr Gly His Gly Lys Ser Phe His His Gln Lys His           
            100                 105                 110                   

uug ccu caa gcc agu acc cag acc ccu gag gcc gca gag ggg aca ccu        921
Leu Pro Gln Ala Ser Thr Gln Thr Pro Glu Ala Ala Glu Gly Thr Pro           
        115                 120                 125                       

ucg gac acg agc acc ccu gca cau agu cag agc acu cag cac ucc acu        969
Ser Asp Thr Ser Thr Pro Ala His Ser Gln Ser Thr Gln His Ser Thr           
    130                 135                 140                           

cuu cca uca gga gca cug ucc uua aac aaa gag cac acc caa ccc ugg       1017
Leu Pro Ser Gly Ala Leu Ser Leu Asn Lys Glu His Thr Gln Pro Trp           
145                 150                 155                 160           

gag aug acc acu cuc ccu uca ggc uau ggu cug gaa gcu agg ccu gag       1065
Glu Met Thr Thr Leu Pro Ser Gly Tyr Gly Leu Glu Ala Arg Pro Glu           
                165                 170                 175               

gcu gag gca aau gag aaa cag caa gau gac aga cag caa gaa gca cca       1113
Ala Glu Ala Asn Glu Lys Gln Gln Asp Asp Arg Gln Gln Glu Ala Pro           
            180                 185                 190                   

gga gcu gga gcu agc aca cca gcu ugg gua ccg gug cug ucc cuc cug       1161
Gly Ala Gly Ala Ser Thr Pro Ala Trp Val Pro Val Leu Ser Leu Leu           
        195                 200                 205                       

gcc auu guc uuc uuc cuc acu gca gcc aug gcc uau gug cug ugc aac       1209
Ala Ile Val Phe Phe Leu Thr Ala Ala Met Ala Tyr Val Leu Cys Asn           
    210                 215                 220                           

agg aga gcg aca cag cag aac ucu gca ggu uug cag cuc ugg uac acu       1257
Arg Arg Ala Thr Gln Gln Asn Ser Ala Gly Leu Gln Leu Trp Tyr Thr           
225                 230                 235                 240           

ccu guu gaa cca aga ccc uag cgccuacagc aagaguggaa gcucaugaga          1308
Pro Val Glu Pro Arg Pro                                                   
                245                                                       

gauggaugau gacaugggag aggugguagg gcagcaggcu cgucuccauc agugaaugga     1368

accugagcuc acuguuucuc augcugucuu gagacaaagu auccauaugg aaccuagguu     1428

agcuuugacc ugcugacccu uugccucuac cuccuagauu cugcgauuaa agacauaugc     1488

uaccacaucu gcccccauug acauucauaa aaaagguaug gauuuccagg guuuuguugu     1548

uuagcuaaga uguuauuuag uccaagccag ccucaaauuc ucuauguaua ugacuacgua     1608

ucccuagguc uccugccuuc ccuauguaua ugacuacgua ucccuagguc uccagccuuc     1668

ccuauguaua ugacuacgua ucccuagguc uccagccuuc ccuguguaua ugacuacgua     1728

ucccuagguc uccugccuuc ccuguguaua ugacuacgua ucccuagguc uccugccuuc     1788

ccuauguaua ugacuacgua ucccuagguc uccagccuuc ccuauguaua ugacuacaua     1848

ucccuagguc uccagccuuc ccuauguaua ugacuacgua ucccuagguc uccagccuuc     1908

ccuguguaua ugacuacgua ucccuagguc uccagccuuc ccuguguaua ugacuacgua     1968

ucccuagguc uccagccuuc ccuguguaua ugacuaugua uccccagguc uccagccuuc     2028

ccuguguaua ugacuacgua ucccuagguc uccugccucc acuuucuaua gugcuaggau     2088

uacagucgcu gaauacuuuu uuuuuuuuuu uuuaagacag gguuucacua uucagcccug     2148

acaguccuaa aacucagaag aucugccugc cucugcagug uugggauuaa aggacugcuc     2208

uuggggaaca cucuuuacaa cuaauaauau augaauagcc ccucugcccu uagccuuccc     2268

ccacgucuaa uaaaauguaa cacucaaaua cgugguucaa aagugcaguc ccaagguaca     2328

gugccugcuu agcaugugua aaguucuagg uucaacccuc ccacuaccag aucaauuuua     2388

aaaagugucu gcuuuuugca uaguguaaca auaaacugga caaauucugu uuuuaacugu     2448


<210>  12
<211>  246
<212>  PRT
<213>  Mus musculus

<400>  12

Met Arg Arg Gly Phe Gly Pro Leu Ser Leu Ala Phe Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ala Leu Leu Thr Leu Pro Gly Asp Gly Asn Gln Gly Ser Val Ala 
            20                  25                  30          


Gly Ser Cys Ser Cys Asp Arg Thr Ile Ser Ser Gly Thr Gln Ile Pro 
        35                  40                  45              


Gln Gly Thr Leu Asp His Ile Arg Lys Tyr Leu Lys Ala Phe His Arg 
    50                  55                  60                  


Cys Pro Phe Phe Ile Arg Phe Gln Leu Gln Ser Lys Ser Val Cys Gly 
65                  70                  75                  80  


Gly Ser Gln Asp Gln Trp Val Arg Glu Leu Val Asp Cys Phe Glu Arg 
                85                  90                  95      


Lys Glu Cys Gly Thr Gly His Gly Lys Ser Phe His His Gln Lys His 
            100                 105                 110         


Leu Pro Gln Ala Ser Thr Gln Thr Pro Glu Ala Ala Glu Gly Thr Pro 
        115                 120                 125             


Ser Asp Thr Ser Thr Pro Ala His Ser Gln Ser Thr Gln His Ser Thr 
    130                 135                 140                 


Leu Pro Ser Gly Ala Leu Ser Leu Asn Lys Glu His Thr Gln Pro Trp 
145                 150                 155                 160 


Glu Met Thr Thr Leu Pro Ser Gly Tyr Gly Leu Glu Ala Arg Pro Glu 
                165                 170                 175     


Ala Glu Ala Asn Glu Lys Gln Gln Asp Asp Arg Gln Gln Glu Ala Pro 
            180                 185                 190         


Gly Ala Gly Ala Ser Thr Pro Ala Trp Val Pro Val Leu Ser Leu Leu 
        195                 200                 205             


Ala Ile Val Phe Phe Leu Thr Ala Ala Met Ala Tyr Val Leu Cys Asn 
    210                 215                 220                 


Arg Arg Ala Thr Gln Gln Asn Ser Ala Gly Leu Gln Leu Trp Tyr Thr 
225                 230                 235                 240 


Pro Val Glu Pro Arg Pro 
                245     


<210>  13
<211>  849
<212>  RNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (34)..(393)

<400>  13
accucguccc aacaagcucc gcagaagccg gag aug agg cgg ggc uuu gga ccc        54
                                     Met Arg Arg Gly Phe Gly Pro          
                                     1               5                    

uug ucu cuu gcg uuc uuc cuu uuc uug uug gcg cug cug acc cug cca        102
Leu Ser Leu Ala Phe Phe Leu Phe Leu Leu Ala Leu Leu Thr Leu Pro           
        10                  15                  20                        

ggc gau ggc aac cag ggc agu guc gcu gga agu ugu ucu ugu gau cgu        150
Gly Asp Gly Asn Gln Gly Ser Val Ala Gly Ser Cys Ser Cys Asp Arg           
    25                  30                  35                            

acc auu ucu ucu ggc acc cag aua ccg cag ggu acu uug gau cac auc        198
Thr Ile Ser Ser Gly Thr Gln Ile Pro Gln Gly Thr Leu Asp His Ile           
40                  45                  50                  55            

cga aaa uac cug aaa gca uuu cau cgu ugu cca uuc uuu auc agg uuc        246
Arg Lys Tyr Leu Lys Ala Phe His Arg Cys Pro Phe Phe Ile Arg Phe           
                60                  65                  70                

cag uug cag ucc aaa agc gug ugu ggg gga agc caa gac cag ugg guc        294
Gln Leu Gln Ser Lys Ser Val Cys Gly Gly Ser Gln Asp Gln Trp Val           
            75                  80                  85                    

cgu gaa cua gug gac ugc uuu gag cgc aaa gua gcu ggg auu aua gga        342
Arg Glu Leu Val Asp Cys Phe Glu Arg Lys Val Ala Gly Ile Ile Gly           
        90                  95                  100                       

cuc ugc aac agg cuu gac uuu cac ugc ugu guu guc acu gaa auc acu        390
Leu Cys Asn Arg Leu Asp Phe His Cys Cys Val Val Thr Glu Ile Thr           
    105                 110                 115                           

uga agagugugga acuggucaug ggaagaguuu ucaccaccaa aaacauuugc             443

cucaagccag uacccagacc ccugaggccg cagaggggac accuucggac acgagcaccc      503

cugcacauag ucagagcacu cagcacucca cucuuccauc aggagcacug uccuuaaaca      563

aagagcacac ccaacccugg gagaugacca cucucccuuc aggcuauggu cuggaagcua      623

ggccugaggc ugaggcaaau gagaaacagc aagaugacag acagcaagaa gcaccaggag      683

cuggagcuag cacaccagcu uggguaccgg ugcugucccu ccuggccauu gucuucuucc      743

ucacugcagc cauggccuau gugcugugca acaggagagc gacacagcag aacucugcag      803

guuugcagcu cugguacacu ccuguugaac caagacccua gcgccu                     849


<210>  14
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  14

Met Arg Arg Gly Phe Gly Pro Leu Ser Leu Ala Phe Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ala Leu Leu Thr Leu Pro Gly Asp Gly Asn Gln Gly Ser Val Ala 
            20                  25                  30          


Gly Ser Cys Ser Cys Asp Arg Thr Ile Ser Ser Gly Thr Gln Ile Pro 
        35                  40                  45              


Gln Gly Thr Leu Asp His Ile Arg Lys Tyr Leu Lys Ala Phe His Arg 
    50                  55                  60                  


Cys Pro Phe Phe Ile Arg Phe Gln Leu Gln Ser Lys Ser Val Cys Gly 
65                  70                  75                  80  


Gly Ser Gln Asp Gln Trp Val Arg Glu Leu Val Asp Cys Phe Glu Arg 
                85                  90                  95      


Lys Val Ala Gly Ile Ile Gly Leu Cys Asn Arg Leu Asp Phe His Cys 
            100                 105                 110         


Cys Val Val Thr Glu Ile Thr 
        115                 


<210>  15
<211>  900
<212>  RNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (34)..(393)

<400>  15
accucguccc aacaagcucc gcagaagccg gag aug agg cgg ggc uuu gga ccc        54
                                     Met Arg Arg Gly Phe Gly Pro          
                                     1               5                    

uug ucu cuu gcg uuc uuc cuu uuc uug uug gcg cug cug acc cug cca        102
Leu Ser Leu Ala Phe Phe Leu Phe Leu Leu Ala Leu Leu Thr Leu Pro           
        10                  15                  20                        

ggc gau ggc aac cag ggc agu guc gcu gga agu ugu ucu ugu gau cgu        150
Gly Asp Gly Asn Gln Gly Ser Val Ala Gly Ser Cys Ser Cys Asp Arg           
    25                  30                  35                            

acc auu ucu ucu ggc acc cag aua ccg cag ggu acu uug gau cac auc        198
Thr Ile Ser Ser Gly Thr Gln Ile Pro Gln Gly Thr Leu Asp His Ile           
40                  45                  50                  55            

cga aaa uac cug aaa gca uuu cau cgu ugu cca uuc uuu auc agg uuc        246
Arg Lys Tyr Leu Lys Ala Phe His Arg Cys Pro Phe Phe Ile Arg Phe           
                60                  65                  70                

cag uug cag ucc aaa agc gug ugu ggg gga agc caa gac cag ugg guc        294
Gln Leu Gln Ser Lys Ser Val Cys Gly Gly Ser Gln Asp Gln Trp Val           
            75                  80                  85                    

cgu gaa cua gug gac ugc uuu gag cgc aaa gua gcu ggg auu aua gga        342
Arg Glu Leu Val Asp Cys Phe Glu Arg Lys Val Ala Gly Ile Ile Gly           
        90                  95                  100                       

cuc ugc aac agg cuu gac uuu cac ugc ugu guu guc acu gaa auc acu        390
Leu Cys Asn Arg Leu Asp Phe His Cys Cys Val Val Thr Glu Ile Thr           
    105                 110                 115                           

uga agauacccug ggccuuuuac ucugaagaaa gucccagaag gcuguagaug             443

aggagugugg aacuggucau gggaagaguu uucaccacca aaaacauuug ccucaagcca      503

guacccagac cccugaggcc gcagagggga caccuucgga cacgagcacc ccugcacaua      563

gucagagcac ucagcacucc acucuuccau caggagcacu guccuuaaac aaagagcaca      623

cccaacccug ggagaugacc acucucccuu caggcuaugg ucuggaagcu aggccugagg      683

cugaggcaaa ugagaaacag caagaugaca gacagcaaga agcaccagga gcuggagcua      743

gcacaccagc uuggguaccg gugcuguccc uccuggccau ugucuucuuc cucacugcag      803

ccauggccua ugugcugugc aacaggagag cgacacagca gaacucugca gguuugcagc      863

ucugguacac uccuguugaa ccaagacccu agcgccu                               900


<210>  16
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  16

Met Arg Arg Gly Phe Gly Pro Leu Ser Leu Ala Phe Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ala Leu Leu Thr Leu Pro Gly Asp Gly Asn Gln Gly Ser Val Ala 
            20                  25                  30          


Gly Ser Cys Ser Cys Asp Arg Thr Ile Ser Ser Gly Thr Gln Ile Pro 
        35                  40                  45              


Gln Gly Thr Leu Asp His Ile Arg Lys Tyr Leu Lys Ala Phe His Arg 
    50                  55                  60                  


Cys Pro Phe Phe Ile Arg Phe Gln Leu Gln Ser Lys Ser Val Cys Gly 
65                  70                  75                  80  


Gly Ser Gln Asp Gln Trp Val Arg Glu Leu Val Asp Cys Phe Glu Arg 
                85                  90                  95      


Lys Val Ala Gly Ile Ile Gly Leu Cys Asn Arg Leu Asp Phe His Cys 
            100                 105                 110         


Cys Val Val Thr Glu Ile Thr 
        115                 


<210>  17
<211>  1001
<212>  RNA
<213>  Bos taurus


<220>
<221>  CDS
<222>  (24)..(782)

<400>  17
gagacagaac gcggcgggcu gag aug aug cug ggc cgg aca ucc cgg uua cuc       53
                          Met Met Leu Gly Arg Thr Ser Arg Leu Leu         
                          1               5                   10          

uug guc cua cug uuu aua gcu uau gcc acu acu uca ggc aau ggc aac        101
Leu Val Leu Leu Phe Ile Ala Tyr Ala Thr Thr Ser Gly Asn Gly Asn           
                15                  20                  25                

gaa ggc agc aag guu ggg agu ugu ccc ugc gau cau aca guc ucu ucc        149
Glu Gly Ser Lys Val Gly Ser Cys Pro Cys Asp His Thr Val Ser Ser           
            30                  35                  40                    

cau ucc ccc cca aac gag aau auc aug aga cau cuc cga aaa uac cug        197
His Ser Pro Pro Asn Glu Asn Ile Met Arg His Leu Arg Lys Tyr Leu           
        45                  50                  55                        

aaa gca uau cag cgc ugu uuu ucc uac guc agg uuc cag cua ccc cuc        245
Lys Ala Tyr Gln Arg Cys Phe Ser Tyr Val Arg Phe Gln Leu Pro Leu           
    60                  65                  70                            

aaa aau gua ugu gga ggc agc acu gac ggc ugg guu cag gag cug aug        293
Lys Asn Val Cys Gly Gly Ser Thr Asp Gly Trp Val Gln Glu Leu Met           
75                  80                  85                  90            

cac ugc uuu gac agu gga gaa ugu gga cau gcu caa ccu agg gug gug        341
His Cys Phe Asp Ser Gly Glu Cys Gly His Ala Gln Pro Arg Val Val           
                95                  100                 105               

gau gca ccu cuu cac aga acc cag cuu ccc gag ccc aca gaa gcg gca        389
Asp Ala Pro Leu His Arg Thr Gln Leu Pro Glu Pro Thr Glu Ala Ala           
            110                 115                 120                   

ccg uca gac aca gcc acc acu ucc cag acg uau cug cca ucc acc uug        437
Pro Ser Asp Thr Ala Thr Thr Ser Gln Thr Tyr Leu Pro Ser Thr Leu           
        125                 130                 135                       

cag cgu acc cag caa ccc acc ccu cug gaa gga gca cug ucc uug gac        485
Gln Arg Thr Gln Gln Pro Thr Pro Leu Glu Gly Ala Leu Ser Leu Asp           
    140                 145                 150                           

agc aag cuc auc ccc acc cau gaa acu acc acu uac acu uca ggc cac        533
Ser Lys Leu Ile Pro Thr His Glu Thr Thr Thr Tyr Thr Ser Gly His           
155                 160                 165                 170           

agu cug ggg gca gag ccu gag gcu aag gag aac cag aag cag cug aaa        581
Ser Leu Gly Ala Glu Pro Glu Ala Lys Glu Asn Gln Lys Gln Leu Lys           
                175                 180                 185               

gaa aac agg ggu ccu cag gcu ggg aca uca gcc acg guc ccu gug cug        629
Glu Asn Arg Gly Pro Gln Ala Gly Thr Ser Ala Thr Val Pro Val Leu           
            190                 195                 200                   

ucc cuc uug gcc auc guu uuc auc cuc gcu gga guc cua cuc uac guc        677
Ser Leu Leu Ala Ile Val Phe Ile Leu Ala Gly Val Leu Leu Tyr Val           
        205                 210                 215                       

gug ugc aag cgg agg aag aau cag cuc cua cag cau ccc cca gau cuu        725
Val Cys Lys Arg Arg Lys Asn Gln Leu Leu Gln His Pro Pro Asp Leu           
    220                 225                 230                           

gca gcu uca uua uau acc ugc agc aga cga acc agg gca gag aau gga        773
Ala Ala Ser Leu Tyr Thr Cys Ser Arg Arg Thr Arg Ala Glu Asn Gly           
235                 240                 245                 250           

acc uug uga gggcagauug ugauuuauuc agcaugaauu aauauacuag                822
Thr Leu                                                                   
                                                                          

aacaauuuuu gguagacacu guacuuauug gucaguguuu aauucacaac uaaccagcua      882

uugaccuacc uuagacuuuu cuucuguucu uuuggauuuu uucuauaccg ugauauaaaa      942

uugcuguuua ugucuuguau aaauuccaua uuuuuuaacu accaaaaaaa aaaaaaaaa      1001


<210>  18
<211>  252
<212>  PRT
<213>  Bos taurus

<400>  18

Met Met Leu Gly Arg Thr Ser Arg Leu Leu Leu Val Leu Leu Phe Ile 
1               5                   10                  15      


Ala Tyr Ala Thr Thr Ser Gly Asn Gly Asn Glu Gly Ser Lys Val Gly 
            20                  25                  30          


Ser Cys Pro Cys Asp His Thr Val Ser Ser His Ser Pro Pro Asn Glu 
        35                  40                  45              


Asn Ile Met Arg His Leu Arg Lys Tyr Leu Lys Ala Tyr Gln Arg Cys 
    50                  55                  60                  


Phe Ser Tyr Val Arg Phe Gln Leu Pro Leu Lys Asn Val Cys Gly Gly 
65                  70                  75                  80  


Ser Thr Asp Gly Trp Val Gln Glu Leu Met His Cys Phe Asp Ser Gly 
                85                  90                  95      


Glu Cys Gly His Ala Gln Pro Arg Val Val Asp Ala Pro Leu His Arg 
            100                 105                 110         


Thr Gln Leu Pro Glu Pro Thr Glu Ala Ala Pro Ser Asp Thr Ala Thr 
        115                 120                 125             


Thr Ser Gln Thr Tyr Leu Pro Ser Thr Leu Gln Arg Thr Gln Gln Pro 
    130                 135                 140                 


Thr Pro Leu Glu Gly Ala Leu Ser Leu Asp Ser Lys Leu Ile Pro Thr 
145                 150                 155                 160 


His Glu Thr Thr Thr Tyr Thr Ser Gly His Ser Leu Gly Ala Glu Pro 
                165                 170                 175     


Glu Ala Lys Glu Asn Gln Lys Gln Leu Lys Glu Asn Arg Gly Pro Gln 
            180                 185                 190         


Ala Gly Thr Ser Ala Thr Val Pro Val Leu Ser Leu Leu Ala Ile Val 
        195                 200                 205             


Phe Ile Leu Ala Gly Val Leu Leu Tyr Val Val Cys Lys Arg Arg Lys 
    210                 215                 220                 


Asn Gln Leu Leu Gln His Pro Pro Asp Leu Ala Ala Ser Leu Tyr Thr 
225                 230                 235                 240 


Cys Ser Arg Arg Thr Arg Ala Glu Asn Gly Thr Leu 
                245                 250         


<210>  19
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ag85A 99-118aa

<400>  19

Thr Phe Leu Thr Ser Glu Leu Pro Gly Trp Leu Gln Ala Asn Arg His 
1               5                   10                  15      


Val Lys Pro Thr 
            20  


<210>  20
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ag85A 70-78aa

<400>  20

Met Pro Val Gly Gly Gln Ser Ser Phe 
1               5                   


<210>  21
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ag85A 145-152aa

<400>  21

Tyr Ala Gly Ala Met Ser Gly Leu 
1               5               


