                         SEQUENCE LISTING

<110>  BASF SE
 
<120>  Verfahren zur Herstellung hochkonzentrierter Lsungen von 
       selbstassemblierenden Proteinene

<130>  M/50289

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  1731
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetisches Spinnenseidenprotein


<220>
<221>  CDS
<222>  (1)..(1731)

<400>  1
atg gct agc atg act ggt gga cag caa atg ggt cgc gga tcc atg ggt       48
Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser Met Gly         
1               5                   10                  15              

tct agc gcg gct gca gcc gcg gca gct gcg tcc ggc ccg ggt ggc tac       96
Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr         
            20                  25                  30                  

ggt ccg gaa aac cag ggt cca tct ggc ccg ggt ggc tac ggt cct ggc      144
Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly         
        35                  40                  45                      

ggt ccg ggt tct agc gcg gct gca gcc gcg gca gct gcg tcc ggc ccg      192
Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro         
    50                  55                  60                          

ggt ggc tac ggt ccg gaa aac cag ggt cca tct ggc ccg ggt ggc tac      240
Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr         
65                  70                  75                  80          

ggt cct ggc ggt ccg ggt tct agc gcg gct gca gcc gcg gca gct gcg      288
Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala         
                85                  90                  95              

tcc ggc ccg ggt ggc tac ggt ccg gaa aac cag ggt cca tct ggc ccg      336
Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro         
            100                 105                 110                 

ggt ggc tac ggt cct ggc ggt ccg ggt tct agc gcg gct gca gcc gcg      384
Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala         
        115                 120                 125                     

gca gct gcg tcc ggc ccg ggt ggc tac ggt ccg gaa aac cag ggt cca      432
Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro         
    130                 135                 140                         

tct ggc ccg ggt ggc tac ggt cct ggc ggt ccg ggt tct agc gcg gct      480
Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala         
145                 150                 155                 160         

gca gcc gcg gca gct gcg tcc ggc ccg ggt ggc tac ggt ccg gaa aac      528
Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn         
                165                 170                 175             

cag ggt cca tct ggc ccg ggt ggc tac ggt cct ggc ggt ccg ggt tct      576
Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser         
            180                 185                 190                 

agc gcg gct gca gcc gcg gca gct gcg tcc ggc ccg ggt ggc tac ggt      624
Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly         
        195                 200                 205                     

ccg gaa aac cag ggt cca tct ggc ccg ggt ggc tac ggt cct ggc ggt      672
Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly         
    210                 215                 220                         

ccg ggt tct agc gcg gct gca gcc gcg gca gct gcg tcc ggc ccg ggt      720
Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly         
225                 230                 235                 240         

ggc tac ggt ccg gaa aac cag ggt cca tct ggc ccg ggt ggc tac ggt      768
Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly         
                245                 250                 255             

cct ggc ggt ccg ggt tct agc gcg gct gca gcc gcg gca gct gcg tcc      816
Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser         
            260                 265                 270                 

ggc ccg ggt ggc tac ggt ccg gaa aac cag ggt cca tct ggc ccg ggt      864
Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly         
        275                 280                 285                     

ggc tac ggt cct ggc ggt ccg ggt tct agc gcg gct gca gcc gcg gca      912
Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala         
    290                 295                 300                         

gct gcg tcc ggc ccg ggt ggc tac ggt ccg gaa aac cag ggt cca tct      960
Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser         
305                 310                 315                 320         

ggc ccg ggt ggc tac ggt cct ggc ggt ccg ggt tct agc gcg gct gca     1008
Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala         
                325                 330                 335             

gcc gcg gca gct gcg tcc ggc ccg ggt ggc tac ggt ccg gaa aac cag     1056
Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln         
            340                 345                 350                 

ggt cca tct ggc ccg ggt ggc tac ggt cct ggc ggt ccg ggt tct agc     1104
Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser         
        355                 360                 365                     

gcg gct gca gcc gcg gca gct gcg tcc ggc ccg ggt ggc tac ggt ccg     1152
Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro         
    370                 375                 380                         

gaa aac cag ggt cca tct ggc ccg ggt ggc tac ggt cct ggc ggt ccg     1200
Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro         
385                 390                 395                 400         

ggt tct agc gcg gct gca gcc gcg gca gct gcg tcc ggc ccg ggt ggc     1248
Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly         
                405                 410                 415             

tac ggt ccg gaa aac cag ggt cca tct ggc ccg ggt ggc tac ggt cct     1296
Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro         
            420                 425                 430                 

ggc ggt ccg ggt tct agc gcg gct gca gcc gcg gca gct gcg tcc ggc     1344
Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly         
        435                 440                 445                     

ccg ggt ggc tac ggt ccg gaa aac cag ggt cca tct ggc ccg ggt ggc     1392
Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly         
    450                 455                 460                         

tac ggt cct ggc ggt ccg ggt tct agc gcg gct gca gcc gcg gca gct     1440
Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala         
465                 470                 475                 480         

gcg tcc ggc ccg ggt ggc tac ggt ccg gaa aac cag ggt cca tct ggc     1488
Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly         
                485                 490                 495             

ccg ggt ggc tac ggt cct ggc ggt ccg ggt tct agc gcg gct gca gcc     1536
Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala         
            500                 505                 510                 

gcg gca gct gcg tcc ggc ccg ggt ggc tac ggt ccg gaa aac cag ggt     1584
Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly         
        515                 520                 525                     

cca tct ggc ccg ggt ggc tac ggt cct ggc ggt ccg ggt tct agc gcg     1632
Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala         
    530                 535                 540                         

gct gca gcc gcg gca gct gcg tcc ggc ccg ggt ggc tac ggt ccg gaa     1680
Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu         
545                 550                 555                 560         

aac cag ggt cca tct ggc ccg ggt ggc tac ggt cct ggc ggt ccg ggc     1728
Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly         
                565                 570                 575             

taa                                                                 1731


<210>  2
<211>  576
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  2

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser Met Gly 
1               5                   10                  15      


Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr 
            20                  25                  30          


Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly 
        35                  40                  45              


Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro 
    50                  55                  60                  


Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr 
65                  70                  75                  80  


Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro 
            100                 105                 110         


Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro 
    130                 135                 140                 


Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala 
145                 150                 155                 160 


Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn 
                165                 170                 175     


Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser 
            180                 185                 190         


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly 
        195                 200                 205             


Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly 
    210                 215                 220                 


Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly 
225                 230                 235                 240 


Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly 
                245                 250                 255     


Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser 
            260                 265                 270         


Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly 
        275                 280                 285             


Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser 
305                 310                 315                 320 


Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala 
                325                 330                 335     


Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln 
            340                 345                 350         


Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser 
        355                 360                 365             


Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro 
    370                 375                 380                 


Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro 
385                 390                 395                 400 


Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly 
                405                 410                 415     


Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro 
            420                 425                 430         


Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly 
        435                 440                 445             


Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly Pro Gly Gly 
    450                 455                 460                 


Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
465                 470                 475                 480 


Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly Pro Ser Gly 
                485                 490                 495     


Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala Ala Ala Ala 
            500                 505                 510         


Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu Asn Gln Gly 
        515                 520                 525             


Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly Ser Ser Ala 
    530                 535                 540                 


Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gly Tyr Gly Pro Glu 
545                 550                 555                 560 


Asn Gln Gly Pro Ser Gly Pro Gly Gly Tyr Gly Pro Gly Gly Pro Gly 
                565                 570                 575     


<210>  3
<211>  1683
<212>  DNA
<213>  Artificial

<220>
<223>  R16 Seidenprotein


<220>
<221>  CDS
<222>  (1)..(1683)

<400>  3
atg gct agc atg act ggt gga cag caa atg ggt cgc gga tcc atg ggc       48
Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser Met Gly         
1               5                   10                  15              

ccg ggt tct agc gcg gct gca gcc gcg gca gct gcg tcc ggc ccg ggt       96
Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly         
            20                  25                  30                  

cag ggc cag ggt cag ggt caa ggc cag ggt ggc cgt cct tct gac acc      144
Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr         
        35                  40                  45                      

tac ggc ccg ggt tct agc gcg gct gca gcc gcg gca gct gcg tcc ggc      192
Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly         
    50                  55                  60                          

ccg ggt cag ggc cag ggt cag ggt caa ggc cag ggt ggc cgt cct tct      240
Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser         
65                  70                  75                  80          

gac acc tac ggc ccg ggt tct agc gcg gct gca gcc gcg gca gct gcg      288
Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala         
                85                  90                  95              

tcc ggc ccg ggt cag ggc cag ggt cag ggt caa ggc cag ggt ggc cgt      336
Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg         
            100                 105                 110                 

cct tct gac acc tac ggc ccg ggt tct agc gcg gct gca gcc gcg gca      384
Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala         
        115                 120                 125                     

gct gcg tcc ggc ccg ggt cag ggc cag ggt cag ggt caa ggc cag ggt      432
Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly         
    130                 135                 140                         

ggc cgt cct tct gac acc tac ggc ccg ggt tct agc gcg gct gca gcc      480
Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala         
145                 150                 155                 160         

gcg gca gct gcg tcc ggc ccg ggt cag ggc cag ggt cag ggt caa ggc      528
Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly         
                165                 170                 175             

cag ggt ggc cgt cct tct gac acc tac ggc ccg ggt tct agc gcg gct      576
Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala         
            180                 185                 190                 

gca gcc gcg gca gct gcg tcc ggc ccg ggt cag ggc cag ggt cag ggt      624
Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly         
        195                 200                 205                     

caa ggc cag ggt ggc cgt cct tct gac acc tac ggc ccg ggt tct agc      672
Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser         
    210                 215                 220                         

gcg gct gca gcc gcg gca gct gcg tcc ggc ccg ggt cag ggc cag ggt      720
Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly         
225                 230                 235                 240         

cag ggt caa ggc cag ggt ggc cgt cct tct gac acc tac ggc ccg ggt      768
Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly         
                245                 250                 255             

tct agc gcg gct gca gcc gcg gca gct gcg tcc ggc ccg ggt cag ggc      816
Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly         
            260                 265                 270                 

cag ggt cag ggt caa ggc cag ggt ggc cgt cct tct gac acc tac ggc      864
Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly         
        275                 280                 285                     

ccg ggt tct agc gcg gct gca gcc gcg gca gct gcg tcc ggc ccg ggt      912
Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly         
    290                 295                 300                         

cag ggc cag ggt cag ggt caa ggc cag ggt ggc cgt cct tct gac acc      960
Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr         
305                 310                 315                 320         

tac ggc ccg ggt tct agc gcg gct gca gcc gcg gca gct gcg tcc ggc     1008
Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly         
                325                 330                 335             

ccg ggt cag ggc cag ggt cag ggt caa ggc cag ggt ggc cgt cct tct     1056
Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser         
            340                 345                 350                 

gac acc tac ggc ccg ggt tct agc gcg gct gca gcc gcg gca gct gcg     1104
Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala         
        355                 360                 365                     

tcc ggc ccg ggt cag ggc cag ggt cag ggt caa ggc cag ggt ggc cgt     1152
Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg         
    370                 375                 380                         

cct tct gac acc tac ggc ccg ggt tct agc gcg gct gca gcc gcg gca     1200
Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala         
385                 390                 395                 400         

gct gcg tcc ggc ccg ggt cag ggc cag ggt cag ggt caa ggc cag ggt     1248
Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly         
                405                 410                 415             

ggc cgt cct tct gac acc tac ggc ccg ggt tct agc gcg gct gca gcc     1296
Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala         
            420                 425                 430                 

gcg gca gct gcg tcc ggc ccg ggt cag ggc cag ggt cag ggt caa ggc     1344
Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly         
        435                 440                 445                     

cag ggt ggc cgt cct tct gac acc tac ggc ccg ggt tct agc gcg gct     1392
Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala         
    450                 455                 460                         

gca gcc gcg gca gct gcg tcc ggc ccg ggt cag ggc cag ggt cag ggt     1440
Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly         
465                 470                 475                 480         

caa ggc cag ggt ggc cgt cct tct gac acc tac ggc ccg ggt tct agc     1488
Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser         
                485                 490                 495             

gcg gct gca gcc gcg gca gct gcg tcc ggc ccg ggt cag ggc cag ggt     1536
Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly         
            500                 505                 510                 

cag ggt caa ggc cag ggt ggc cgt cct tct gac acc tac ggc ccg ggt     1584
Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly         
        515                 520                 525                     

tct agc gcg gct gca gcc gcg gca gct gcg tcc ggc ccg ggt cag ggc     1632
Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly         
    530                 535                 540                         

cag ggt cag ggt caa ggc cag ggt ggc cgt cct tct gac acc tac ggc     1680
Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly         
545                 550                 555                 560         

taa                                                                 1683


<210>  4
<211>  560
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  4

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser Met Gly 
1               5                   10                  15      


Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly 
            20                  25                  30          


Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr 
        35                  40                  45              


Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly 
    50                  55                  60                  


Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser 
65                  70                  75                  80  


Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg 
            100                 105                 110         


Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly 
    130                 135                 140                 


Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly 
                165                 170                 175     


Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala 
            180                 185                 190         


Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly 
        195                 200                 205             


Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly 
225                 230                 235                 240 


Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly 
                245                 250                 255     


Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly 
            260                 265                 270         


Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly 
        275                 280                 285             


Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly 
    290                 295                 300                 


Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr 
305                 310                 315                 320 


Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly 
                325                 330                 335     


Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser 
            340                 345                 350         


Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala 
        355                 360                 365             


Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg 
    370                 375                 380                 


Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly Gln Gly 
                405                 410                 415     


Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala Ala Ala 
            420                 425                 430         


Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly Gln Gly 
        435                 440                 445             


Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly Gln Gly 
465                 470                 475                 480 


Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly Ser Ser 
                485                 490                 495     


Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly Gln Gly 
            500                 505                 510         


Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly Pro Gly 
        515                 520                 525             


Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Pro Gly Gln Gly 
    530                 535                 540                 


Gln Gly Gln Gly Gln Gly Gln Gly Gly Arg Pro Ser Asp Thr Tyr Gly 
545                 550                 555                 560 


<210>  5
<211>  1923
<212>  DNA
<213>  Artificial

<220>
<223>  S16 Seidenprotein


<220>
<221>  CDS
<222>  (1)..(1923)

<400>  5
atg gct agc atg act ggt gga cag caa atg ggt cgc gga tcc atg ggt       48
Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser Met Gly         
1               5                   10                  15              

tct gcg gct gca gcc gcg gca gct gcg ggt ccg ggc ggt ggc aac ggt       96
Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly         
            20                  25                  30                  

ggc cgt ccg tct gac acc tac ggt gcg ccg ggt ggc ggt aac ggt ggc      144
Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly         
        35                  40                  45                      

cgt cct tct tcc tct tac ggt tct gcg gct gca gcc gcg gca gct gcg      192
Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala         
    50                  55                  60                          

ggt ccg ggc ggt ggc aac ggt ggc cgt ccg tct gac acc tac ggt gcg      240
Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala         
65                  70                  75                  80          

ccg ggt ggc ggt aac ggt ggc cgt cct tct tcc tct tac ggt tct gcg      288
Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala         
                85                  90                  95              

gct gca gcc gcg gca gct gcg ggt ccg ggc ggt ggc aac ggt ggc cgt      336
Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg         
            100                 105                 110                 

ccg tct gac acc tac ggt gcg ccg ggt ggc ggt aac ggt ggc cgt cct      384
Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro         
        115                 120                 125                     

tct tcc tct tac ggt tct gcg gct gca gcc gcg gca gct gcg ggt ccg      432
Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro         
    130                 135                 140                         

ggc ggt ggc aac ggt ggc cgt ccg tct gac acc tac ggt gcg ccg ggt      480
Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly         
145                 150                 155                 160         

ggc ggt aac ggt ggc cgt cct tct tcc tct tac ggt tct gcg gct gca      528
Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala         
                165                 170                 175             

gcc gcg gca gct gcg ggt ccg ggc ggt ggc aac ggt ggc cgt ccg tct      576
Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser         
            180                 185                 190                 

gac acc tac ggt gcg ccg ggt ggc ggt aac ggt ggc cgt cct tct tcc      624
Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser         
        195                 200                 205                     

tct tac ggt tct gcg gct gca gcc gcg gca gct gcg ggt ccg ggc ggt      672
Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly         
    210                 215                 220                         

ggc aac ggt ggc cgt ccg tct gac acc tac ggt gcg ccg ggt ggc ggt      720
Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly         
225                 230                 235                 240         

aac ggt ggc cgt cct tct tcc tct tac ggt tct gcg gct gca gcc gcg      768
Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala         
                245                 250                 255             

gca gct gcg ggt ccg ggc ggt ggc aac ggt ggc cgt ccg tct gac acc      816
Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr         
            260                 265                 270                 

tac ggt gcg ccg ggt ggc ggt aac ggt ggc cgt cct tct tcc tct tac      864
Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr         
        275                 280                 285                     

ggt tct gcg gct gca gcc gcg gca gct gcg ggt ccg ggc ggt ggc aac      912
Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn         
    290                 295                 300                         

ggt ggc cgt ccg tct gac acc tac ggt gcg ccg ggt ggc ggt aac ggt      960
Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly         
305                 310                 315                 320         

ggc cgt cct tct tcc tct tac ggt tct gcg gct gca gcc gcg gca gct     1008
Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala         
                325                 330                 335             

gcg ggt ccg ggc ggt ggc aac ggt ggc cgt ccg tct gac acc tac ggt     1056
Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly         
            340                 345                 350                 

gcg ccg ggt ggc ggt aac ggt ggc cgt cct tct tcc tct tac ggt tct     1104
Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser         
        355                 360                 365                     

gcg gct gca gcc gcg gca gct gcg ggt ccg ggc ggt ggc aac ggt ggc     1152
Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly         
    370                 375                 380                         

cgt ccg tct gac acc tac ggt gcg ccg ggt ggc ggt aac ggt ggc cgt     1200
Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg         
385                 390                 395                 400         

cct tct tcc tct tac ggt tct gcg gct gca gcc gcg gca gct gcg ggt     1248
Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly         
                405                 410                 415             

ccg ggc ggt ggc aac ggt ggc cgt ccg tct gac acc tac ggt gcg ccg     1296
Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro         
            420                 425                 430                 

ggt ggc ggt aac ggt ggc cgt cct tct tcc tct tac ggt tct gcg gct     1344
Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala         
        435                 440                 445                     

gca gcc gcg gca gct gcg ggt ccg ggc ggt ggc aac ggt ggc cgt ccg     1392
Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro         
    450                 455                 460                         

tct gac acc tac ggt gcg ccg ggt ggc ggt aac ggt ggc cgt cct tct     1440
Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser         
465                 470                 475                 480         

tcc tct tac ggt tct gcg gct gca gcc gcg gca gct gcg ggt ccg ggc     1488
Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly         
                485                 490                 495             

ggt ggc aac ggt ggc cgt ccg tct gac acc tac ggt gcg ccg ggt ggc     1536
Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly         
            500                 505                 510                 

ggt aac ggt ggc cgt cct tct tcc tct tac ggt tct gcg gct gca gcc     1584
Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala         
        515                 520                 525                     

gcg gca gct gcg ggt ccg ggc ggt ggc aac ggt ggc cgt ccg tct gac     1632
Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp         
    530                 535                 540                         

acc tac ggt gcg ccg ggt ggc ggt aac ggt ggc cgt cct tct tcc tct     1680
Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser         
545                 550                 555                 560         

tac ggt tct gcg gct gca gcc gcg gca gct gcg ggt ccg ggc ggt ggc     1728
Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly         
                565                 570                 575             

aac ggt ggc cgt ccg tct gac acc tac ggt gcg ccg ggt ggc ggt aac     1776
Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn         
            580                 585                 590                 

ggt ggc cgt cct tct tcc tct tac ggt tct gcg gct gca gcc gcg gca     1824
Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala         
        595                 600                 605                     

gct gcg ggt ccg ggc ggt ggc aac ggt ggc cgt ccg tct gac acc tac     1872
Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr         
    610                 615                 620                         

ggt gcg ccg ggt ggc ggt aac ggt ggc cgt cct tct tcc tct tac ggc     1920
Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly         
625                 630                 635                 640         

taa                                                                 1923


<210>  6
<211>  640
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  6

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser Met Gly 
1               5                   10                  15      


Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly 
            20                  25                  30          


Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly 
        35                  40                  45              


Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala 
65                  70                  75                  80  


Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg 
            100                 105                 110         


Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro 
        115                 120                 125             


Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro 
    130                 135                 140                 


Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly 
145                 150                 155                 160 


Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser 
            180                 185                 190         


Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser 
        195                 200                 205             


Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly 
    210                 215                 220                 


Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly 
225                 230                 235                 240 


Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr 
            260                 265                 270         


Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr 
        275                 280                 285             


Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn 
    290                 295                 300                 


Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly 
305                 310                 315                 320 


Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala 
                325                 330                 335     


Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly 
            340                 345                 350         


Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser 
        355                 360                 365             


Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly 
    370                 375                 380                 


Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg 
385                 390                 395                 400 


Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly 
                405                 410                 415     


Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro 
            420                 425                 430         


Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala 
        435                 440                 445             


Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro 
    450                 455                 460                 


Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser 
465                 470                 475                 480 


Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly 
                485                 490                 495     


Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly 
            500                 505                 510         


Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala 
        515                 520                 525             


Ala Ala Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp 
    530                 535                 540                 


Thr Tyr Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser 
545                 550                 555                 560 


Tyr Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Gly Gly 
                565                 570                 575     


Asn Gly Gly Arg Pro Ser Asp Thr Tyr Gly Ala Pro Gly Gly Gly Asn 
            580                 585                 590         


Gly Gly Arg Pro Ser Ser Ser Tyr Gly Ser Ala Ala Ala Ala Ala Ala 
        595                 600                 605             


Ala Ala Gly Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Asp Thr Tyr 
    610                 615                 620                 


Gly Ala Pro Gly Gly Gly Asn Gly Gly Arg Pro Ser Ser Ser Tyr Gly 
625                 630                 635                 640 


