                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Antibodies against IL-18R1 and uses thereof

<130>  26956 WO

<150>  EP 10174039.7
<151>  2010-08-25

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  1

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Met Ser Cys Lys Thr Ser Asp Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Tyr Thr Phe Thr 
1               5   


<210>  3
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  3

Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  4

Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val 
1               5                   10          


<210>  5
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  5

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Gly Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Ser Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  6
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  6

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Asp Ser Tyr Met His 
1               5                   10                  15  


<210>  7
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  7

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Gln Ser Arg Glu Leu Pro Leu Ser 
1               5                   


<210>  9
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  9

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Asp Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Tyr Thr Phe Thr Ser Asn Trp Met His 
1               5                   10  


<210>  11
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  11

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Gly Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Ser Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  12
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  12

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  13
<211>  105
<212>  PRT
<213>  homo sapiens

<400>  13

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  14
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  15
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  15

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  16
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  16

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  17
<211>  327
<212>  PRT
<213>  homo sapiens

<400>  17

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  18
<211>  327
<212>  PRT
<213>  homo sapiens

<400>  18

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  19
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Arg Ile Ala Leu 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  20

Pro Arg Val Thr Phe 
1               5   


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Lys Asn Tyr Thr Gln Lys 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  22

Val Gly Asn Asp Arg Arg Asn 
1               5           


<210>  23
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Thr Leu Val Asn Ser Thr Ser 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Glu Leu Ile Gln Asp Thr Trp 
1               5               


<210>  25
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  25

Asn Pro Thr Ile Lys Lys Asn 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  26

Thr Pro Arg Ile Leu Lys Asp 
1               5           


<210>  27
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  27

His Phe Leu His His Asn Gly Lys Leu Phe 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  28

Phe Ser Val His His Asn Gly Thr Arg Tyr 
1               5                   10  


<210>  29
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain variable region (VH) of humanized Mab1G12-9.6

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  30
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH1 humanized Mab1G12-9.6

<400>  30

Asp Tyr Thr Phe Thr 
1               5   


<210>  31
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH2 humanized Mab1G12-9.6

<400>  31

Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH3 humanized Mab1G12-9.6

<400>  32

Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val 
1               5                   10          


<210>  33
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  light chain variable region (VL) of humanized Mab1G12-9.6

<400>  33

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  34
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL1 humanized Mab1G12-9.6

<400>  34

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Asp Ser Tyr Met His 
1               5                   10                  15  


<210>  35
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL2 humanized Mab1G12-9.6

<400>  35

Leu Ala Ser Asn Leu Glu Thr 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL3 humanized Mab1G12-9.6

<400>  36

Gln Gln Ser Arg Glu Leu Pro Leu Ser 
1               5                   


<210>  37
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain variable region (VH) of humanized Mab1G12-10.5

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  38
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH1 humanized Mab1G12-10.5

<400>  38

Asp Tyr Thr Phe Thr 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH2 humanized Mab1G12-10.5

<400>  39

Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH3 humanized Mab1G12-10.5

<400>  40

Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val 
1               5                   10          


<210>  41
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  light chain variable region (VL) of humanized Mab1G12-10.5

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  42
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL1 humanized Mab1G12-10.5

<400>  42

Gln Ala Ser Lys Ser Val Ser Thr Ser Gly Asp Ser Tyr Met His 
1               5                   10                  15  


<210>  43
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL2 humanized Mab1G12-10.5

<400>  43

Leu Ala Ser Asn Leu Glu Thr 
1               5           


<210>  44
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL3 humanized Mab1G12-10.5

<400>  44

Gln Gln Ser Arg Glu Leu Pro Leu Ser 
1               5                   


<210>  45
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain variable region (VH) of humanized Mab1G12-10.6

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  46
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH1 humanized Mab1G12-10.6

<400>  46

Asp Tyr Thr Phe Thr 
1               5   


<210>  47
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH2 humanized Mab1G12-10.6

<400>  47

Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH3 humanized Mab1G12-10.6

<400>  48

Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val 
1               5                   10          


<210>  49
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  light chain variable region (VL) of humanized Mab1G12-10.6

<400>  49

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  50
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL1 humanized Mab1G12-10.6

<400>  50

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Asp Ser Tyr Met His 
1               5                   10                  15  


<210>  51
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL2 humanized Mab1G12-10.6

<400>  51

Leu Ala Ser Asn Leu Glu Thr 
1               5           


<210>  52
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL3 humanized Mab1G12-10.6

<400>  52

Gln Gln Ser Arg Glu Leu Pro Leu Ser 
1               5                   


<210>  53
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain variable region (VH) of humanized Mab1G12-11.6

<400>  53

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  54
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH1 humanized Mab1G12-11.6

<400>  54

Gly Tyr Thr Phe Thr 
1               5   


<210>  55
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH2 humanized Mab1G12-11.6

<400>  55

Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH3 humanized Mab1G12-11.6

<400>  56

Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val 
1               5                   10          


<210>  57
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  light chain variable region (VL) of humanized Mab1G12-11.6

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  58
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL1 humanized Mab1G12-11.6

<400>  58

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Asp Ser Tyr Met His 
1               5                   10                  15  


<210>  59
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL2 humanized Mab1G12-11.6

<400>  59

Leu Ala Ser Asn Leu Glu Thr 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL3 humanized Mab1G12-11.6

<400>  60

Gln Gln Ser Arg Glu Leu Pro Leu Ser 
1               5                   


<210>  61
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain variable region (VH) of humanized Mab1G12-12.6

<400>  61

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  62
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH1 humanized Mab1G12-12.6

<400>  62

Gly Tyr Thr Phe Thr 
1               5   


<210>  63
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH2 humanized Mab1G12-12.6

<400>  63

Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain CDRH3 humanized Mab1G12-12.6

<400>  64

Ser Gly Asp Tyr Asp Ala Asp Arg Tyr Phe Asp Val 
1               5                   10          


<210>  65
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  light chain variable region (VL) of humanized Mab1G12-12.6

<400>  65

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  66
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL1 humanized Mab1G12-12.6

<400>  66

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Asp Ser Tyr Met His 
1               5                   10                  15  


<210>  67
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL2 humanized Mab1G12-12.6

<400>  67

Leu Ala Ser Asn Leu Glu Thr 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  light chain CDRL3 humanized Mab1G12-12.6

<400>  68

Gln Gln Ser Arg Glu Leu Pro Leu Ser 
1               5                   


<210>  69
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is either R or Q

<400>  69

Xaa Ala Ser Lys Ser Val Ser Thr Ser Gly Asp Ser Tyr Met His 
1               5                   10                  15  


<210>  70
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is either D or G

<400>  70

Xaa Tyr Thr Phe Thr 
1               5   


<210>  71
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  X1 is N or A, 

X2 is F or A, and  

X3 is K or Q

<400>  71

Thr Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Xaa Gln Lys Xaa Xaa 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Asn Cys Arg Glu Leu Pro Leu Thr Leu Trp Val Leu Ile Ser Val 
1               5                   10                  15      


Ser Thr Ala Glu Ser Cys Thr Ser Arg Pro His Ile Thr Val Val Glu 
            20                  25                  30          


Gly Glu Pro Phe Tyr Leu Lys His Cys Ser Cys Ser Leu Ala His Glu 
        35                  40                  45              


Ile Glu Thr Thr Thr Lys Ser Trp Tyr Lys Ser Ser Gly Ser Gln Glu 
    50                  55                  60                  


His Val Glu Leu Asn Pro Arg Ser Ser Ser Arg Ile Ala Leu His Asp 
65                  70                  75                  80  


Cys Val Leu Glu Phe Trp Pro Val Glu Leu Asn Asp Thr Gly Ser Tyr 
                85                  90                  95      


Phe Phe Gln Met Lys Asn Tyr Thr Gln Lys Trp Lys Leu Asn Val Ile 
            100                 105                 110         


Arg Arg Asn Lys His Ser Cys Phe Thr Glu Arg Gln Val Thr Ser Lys 
        115                 120                 125             


Ile Val Glu Val Lys Lys Phe Phe Gln Ile Thr Cys Glu Asn Ser Tyr 
    130                 135                 140                 


Tyr Gln Thr Leu Val Asn Ser Thr Ser Leu Tyr Lys Asn Cys Lys Lys 
145                 150                 155                 160 


Leu Leu Leu Glu Asn Asn Lys Asn Pro Thr Ile Lys Lys Asn Ala Glu 
                165                 170                 175     


Phe Glu Asp Gln Gly Tyr Tyr Ser Cys Val His Phe Leu His His Asn 
            180                 185                 190         


Gly Lys Leu Phe Asn Ile Thr Lys Thr Phe Asn Ile Thr Ile Val Glu 
        195                 200                 205             


Asp Arg Ser Asn Ile Val Pro Val Leu Leu Gly Pro Lys Leu Asn His 
    210                 215                 220                 


Val Ala Val Glu Leu Gly Lys Asn Val Arg Leu Asn Cys Ser Ala Leu 
225                 230                 235                 240 


Leu Asn Glu Glu Asp Val Ile Tyr Trp Met Phe Gly Glu Glu Asn Gly 
                245                 250                 255     


Ser Asp Pro Asn Ile His Glu Glu Lys Glu Met Arg Ile Met Thr Pro 
            260                 265                 270         


Glu Gly Lys Trp His Ala Ser Lys Val Leu Arg Ile Glu Asn Ile Gly 
        275                 280                 285             


Glu Ser Asn Leu Asn Val Leu Tyr Asn Cys Thr Val Ala Ser Thr Gly 
    290                 295                 300                 


Gly Thr Asp Thr Lys Ser Phe Ile Leu Val Arg Lys Ala Asp Met Ala 
305                 310                 315                 320 


Asp Ile Pro Gly His Val Phe Thr Arg Gly Met Ile Ile Ala Val Leu 
                325                 330                 335     


Ile Leu Val Ala Val Val Cys Leu Val Thr Val Cys Val Ile Tyr Arg 
            340                 345                 350         


Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp Glu Thr 
        355                 360                 365             


Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu 
    370                 375                 380                 


Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu 
385                 390                 395                 400 


Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu 
                405                 410                 415     


Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His Ser Leu 
            420                 425                 430         


Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr Met 
        435                 440                 445             


Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu Ala Leu 
    450                 455                 460                 


Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro Val Thr 
465                 470                 475                 480 


Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser His Arg 
                485                 490                 495     


Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe 
            500                 505                 510         


Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly 
        515                 520                 525             


Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
    530                 535                 540     


