                         SEQUENCE LISTING

<110>  Codexis, Inc.
       CABIROL, Fabien
       COLLIER, Steven
       GOHEL, Anupam
       LIANG, Jack
       LIMANTO, John
       MOCK, Marissa
       MUNDORFF, Emily
       NOVICK, Scott
       SMITH, Derek
       ASHLEY, Eric
       BEUTNER, Greg
       GRAU, Brendan
       HUGHES, Greg
       JANEY, Jacob
       KLAPARS, Artis
       STROTMAN, Hallena
       TRUPPO, Matt
 
<120>  BIOCATALYTIC SYNTHESIS OF 
       (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE

<130>  CX2-053USP2

<150>  US 61/374,079
<151>  2010-08-16

<150>  US 61/510,256
<151>  2011-07-21

<160>  206   

<170>  PatentIn version 3.5

<210>  1
<211>  993
<212>  DNA
<213>  Arthrobacter sp. KNK168

<400>  1
atggcattca gcgccgatac ctccgagatc gtctacacgc acgacaccgg cctcgactac       60

atcacttata gcgactacga actcgatcct gctaacccgc tcgcgggagg tgcggcatgg      120

atcgagggtg cattcgtgcc gccgtcggag gcgcggatct cgatcttcga tcagggttac      180

ctccactcgg acgtcaccta cacggtcttc cacgtctgga acggaaatgc attccgcctc      240

gacgaccaca tcgaacgcct cttctccaac gcggagtcga tgcgcatcat ccctccgctc      300

acacaggacg aagtgaagga gattgcgctc gaactcgtcg cgaagaccga attgcgtgag      360

gccttcgtgt ccgtgtcgat tacccgcggt tacagctcga ctccgggcga gcgcgacatc      420

acgaagcacc gcccgcaggt gtacatgtat gccgtcccat atcagtggat cgtgccgttt      480

gaccgaattc gcgacggcgt gcacgccatg gtcgcacaga gcgtgcgccg aaccccgcgc      540

agctcgatcg accctcaggt caagaacttc cagtgggggg atctgatccg tgcggttcaa      600

gagacgcacg accgcgggtt cgaggctccc cttctgctcg acggcgatgg actgcttgcc      660

gagggctcgg ggttcaacgt cgtcgtgatc aaggacggcg tcgtgcgcag cccgggtcga      720

gcggcgctcc ccggcattac gcggaagacc gtgctcgaga tcgccgaatc gctcggacac      780

gaggcgattc tcgccgacat cacgctcgct gaactgctcg acgccgacga agtgctcggc      840

tgcacgactg cgggcggagt gtggccattc gtcagcgtgg acggcaaccc catctcggac      900

ggggttcccg gccccatcac ccagtcgatc atccgtcgtt actgggagct gaatgtcgag      960

agctcgtcgt tgcttacgcc tgtgcagtac tga                                   993


<210>  2
<211>  330
<212>  PRT
<213>  Arthrobacter sp. KNK168

<400>  2

Met Ala Phe Ser Ala Asp Thr Ser Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Tyr Leu His Ser Asp 
    50                  55                  60                  


Val Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Asp Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Met Arg Ile 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Gly Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Ala Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Ala Pro Leu Leu Leu Asp Gly Asp Gly Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Leu Ala Glu Leu 
            260                 265                 270         


Leu Asp Ala Asp Glu Val Leu Gly Cys Thr Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Pro Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Ile Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Ser Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  3
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  3
atggctttct ctgctgacac ctctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggttac      180

ctgcactctg acgttaccta caccgttttc cacgtttgga acggtaacgc tttccgtctg      240

gacgaccaca tcgaacgtct gttctctaac gctgaatcta tgcgtatcat cccgccgctg      300

acccaggacg aagttaaaga aatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcattcgttt ctgtttctat cacccgtggt tactcttcta ccccaggtga acgtgacatc      420

accaaacatc gtccgcaggt ttacatgtac gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacgctatg gttgctcagt ctgttcgtcg tactccgcgt      540

tcttctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcagttcag      600

gaaacccacg accgtggttt cgaagctccg ctgctgctgg acggtgacgg tctgctggct      660

gaaggttctg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccctggct gaactgctgg acgctgacga agttctgggt      840

tgcactaccg ctggtggtgt ttggccgttc gtttctgttg acggtaaccc gatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

tcttcttctc tgctgacccc ggtacagtac tga                                   993


<210>  4
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  4

Met Ala Phe Ser Ala Asp Thr Ser Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Tyr Leu His Ser Asp 
    50                  55                  60                  


Val Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Asp Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Met Arg Ile 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Phe Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Gly Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Ala Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Val Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Ala Pro Leu Leu Leu Asp Gly Asp Gly Leu Leu Ala Glu Gly Ser Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Leu Ala Glu Leu 
            260                 265                 270         


Leu Asp Ala Asp Glu Val Leu Gly Cys Thr Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Pro Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Ser Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  5
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  5
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  6
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  6

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  7
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  7
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tttggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttg tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttatcg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgccctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  8
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  8

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Val Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Ser Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  9
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  9
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg ccttgactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatt cctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  10
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  10

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Phe Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  11
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  11
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga accggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  12
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  12

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Pro Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  13
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  13
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatctccga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tgactgacat caccccggct gaactgtacg acgcagacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  14
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  14

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Ser Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Thr Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  15
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  15
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  16
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  16

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  17
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  17
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  18
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  18

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  19
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  19
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tggtgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccag gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  20
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  20

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Gly Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  21
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  21
atggctttct cagctgacac ccctgaagtc gtttacaccc gcgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagtcaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  22
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  22

Met Ala Phe Ser Ala Asp Thr Pro Glu Val Val Tyr Thr Arg Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  23
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  23
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

ggctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  24
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  24

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Gly Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  25
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  25
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggcatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tgactgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  26
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  26

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Thr Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  27
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  27
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  28
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  28

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  29
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  29
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgctgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accagacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  30
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  30

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Leu Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Arg His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  31
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  31
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  32
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  32

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  33
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  33
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttg tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  34
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  34

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Val Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  35
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  35
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttatcg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  36
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  36

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Ser Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  37
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  37
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgaggaatcg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  38
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  38

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Glu Ser Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  39
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  39
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttg tggtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgtcg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  40
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  40

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Val Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Ser Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  41
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  41
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgttttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  42
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  42

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  43
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  43
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgttttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actacgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  44
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  44

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Tyr Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  45
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  45
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgaggagccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  46
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  46

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Glu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  47
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  47
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgttttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacag cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  48
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  48

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Ser Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  49
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  49
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ttttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtaatg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  50
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  50

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Val Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Asn Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  51
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  51
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtaatg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  52
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  52

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Asn Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  53
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  53
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtctgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  54
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  54

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Leu Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  55
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  55
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcctcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta ttgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  56
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  56

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Leu Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  57
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  57
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtattg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  58
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  58

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Ile Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  59
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  59
atggctttct cagctgacgc ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttc ttgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  60
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  60

Met Ala Phe Ser Ala Asp Ala Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Leu Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  61
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  61
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcatatcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  62
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  62

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Tyr Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  63
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  63
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta cacctggttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  64
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  64

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Trp Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  65
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  65
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gctgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  66
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  66

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Ala Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  67
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  67
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ttgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgagtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  68
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  68

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Ser Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  69
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  69
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgaggatccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  70
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  70

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Asp Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  71
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  71
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ttgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgccgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  72
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  72

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Phe Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Pro Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  73
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  73
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta cccaattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcgaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  74
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  74

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Gln Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  75
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  75
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta cacctgtttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  76
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  76

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Cys Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  77
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  77
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagtgtccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctactctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  78
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  78

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Cys Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Thr Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  79
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  79
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttc tggtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  80
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  80

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Leu Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  81
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  81
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  82
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  82

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  83
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  83
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttg tggtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  84
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  84

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Val Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  85
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  85
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcatttcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  86
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  86

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Phe Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  87
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  87
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaaggcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  88
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  88

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Arg Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  89
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  89
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccaccttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgttt ctgtttctat cacccgtggt tactcttcta ccccattcga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagctgccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtatgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  90
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  90

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ser Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Phe Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Met Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  91
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  91
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagtgaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttcac tgctgacccc ggtacagtac                                       990


<210>  92
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  92

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  93
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  93
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtcgat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgttgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacgt caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  94
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  94

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ser Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  95
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  95
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgttactat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgaat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  96
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  96

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Thr Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Asn Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  97
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  97
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatggcg gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  98
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  98

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Ala Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  99
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  99
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgattgtta ttgttaccat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  100
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  100

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Thr Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  101
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  101
atggctttct cagctgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgttgctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg actgcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  102
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  102

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ala Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Cys Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  103
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  103
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

ttcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  104
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  104

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Phe Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  105
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  105
atggcgttct tagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttcag acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtaacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaatacag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgttggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaatt gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  106
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  106

Met Ala Phe Leu Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asn Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  107
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  107
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccactttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  108
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  108

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Thr Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  109
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  109
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

ctgaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  110
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  110

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Leu Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  111
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  111
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accacgcatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  112
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  112

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Thr His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  113
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  113
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcgggga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  114
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  114

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Gly Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  115
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  115
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctttgttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  116
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  116

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Leu Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  117
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  117
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatctc ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  118
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  118

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Leu Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  119
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  119
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agcacgatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  120
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  120

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Thr Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  121
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  121
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga cttgggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  122
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  122

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Leu Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  123
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  123
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatcc ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  124
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  124

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Pro Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  125
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  125
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatca ggatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  126
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  126

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Arg Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  127
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  127
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatca atatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  128
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  128

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Asn Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  129
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  129
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatca agatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  130
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  130

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Lys Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  131
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  131
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtac gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacgt gaccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  132
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  132

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  133
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  133
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtcgat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa catgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  134
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  134

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ser Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Met Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  135
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  135
atggcgttct caaacgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtc aattcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga ggtagctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgttgctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatggct gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa catgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc gatccagtac                                       990


<210>  136
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  136

Met Ala Phe Ser Asn Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Gln Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ala Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Ala Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Met Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Ile Gln Tyr 
                325                 330 


<210>  137
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  137
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtttat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  138
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  138

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Phe Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  139
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  139
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagacgat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgcgcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  140
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  140

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Thr Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  141
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  141
atgaaattct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  142
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  142

Met Lys Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  143
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  143
atgcaattct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  144
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  144

Met Gln Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  145
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  145
atgtcattct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  146
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  146

Met Ser Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  147
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  147
atgcaattct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  148
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  148

Met Gln Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  149
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  149
atggcgttct catccgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  150
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  150

Met Ala Phe Ser Ser Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  151
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  151
atggcgttct caaccgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgagcgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  152
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  152

Met Ala Phe Ser Thr Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  153
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  153
atggcgttct caatcgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  154
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  154

Met Ala Phe Ser Ile Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  155
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  155
atggcgttct cacatgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  156
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  156

Met Ala Phe Ser His Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  157
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  157
atggcgttct cattggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  158
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  158

Met Ala Phe Ser Leu Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  159
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  159
atggcgttct cagtggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga tcagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct cttctctaat gcggaatcta ttcgcttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccacaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  160
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  160

Met Ala Phe Ser Val Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  161
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  161
atggcgttct cattagacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  162
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  162

Met Ala Phe Ser Leu Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  163
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  163
atggcgttct cagcggacac ccctcaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtagctc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  164
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  164

Met Ala Phe Ser Ala Asp Thr Pro Gln Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Ser Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  165
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  165
atggcgttca ttgcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  166
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  166

Met Ala Phe Ile Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  167
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  167
atggcgttct cagcggacac ccctagtatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  168
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  168

Met Ala Phe Ser Ala Asp Thr Pro Ser Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  169
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  169
atggcgttct cagcggacac cacagaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  170
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  170

Met Ala Phe Ser Ala Asp Thr Thr Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  171
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  171
atggcgttct cagcggacac ccctaatatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  172
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  172

Met Ala Phe Ser Ala Asp Thr Pro Asn Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  173
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  173
atggcgttct tagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  174
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  174

Met Ala Phe Leu Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  175
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  175
atggcgttct cagcggacac ccctgaaatc aaatacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  176
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  176

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Lys Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  177
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  177
atgagcttct cacatgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgttgctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtcgat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacgt caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  178
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  178

Met Ser Phe Ser His Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ala Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ser Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Val Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  179
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  179
atgagcttct cacatgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  180
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  180

Met Ser Phe Ser His Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  181
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  181
atgagcttct caaacgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtc aattcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga ggtagctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgttgctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatggct gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa catgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc gatccagtac                                       990


<210>  182
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  182

Met Ser Phe Ser Asn Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Gln Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Val Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ala Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Ala Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Met Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Ile Gln Tyr 
                325                 330 


<210>  183
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  183
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtag ggctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  184
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  184

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Arg Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  185
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  185
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tcttgactat       60

atcatctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  186
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  186

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Ile Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  187
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  187
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgcgggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  188
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  188

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Ala Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  189
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  189
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctaagatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  190
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  190

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Lys Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  191
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  191
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcg ctgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  192
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  192

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Ala Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  193
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  193
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt acgcttggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  194
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  194

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Ala Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  195
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  195
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgttt gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  196
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  196

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Phe Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  197
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  197
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accaggggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  198
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  198

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Gly Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  199
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  199
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accaggcgat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  200
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  200

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ala Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  201
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  201
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagagtat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  202
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  202

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Ser Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  203
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  203
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggtt ggtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  204
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  204

Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Leu Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210>  205
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  205
atggcgttct cacatgacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgctgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatca gcatcgggga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatctc tgcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga actgcgtgaa      360

gcgatcgtta tcgtttctat cacccgtggt tactcttcta ccccatggga gcgtgacatc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc cagtggggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg acttcgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgtacg acgctgacga agttctgggt      840

tgctcaaccg gtggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttctc tgctgacccc ggtacagtac                                       990


<210>  206
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered variant of Arthrobacter transaminase

<400>  206

Met Ala Phe Ser His Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Gly Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Leu Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Ile Val Ser Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Trp Glu Arg Asp Ile Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Gln Trp 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Tyr Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Gly Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Ser Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


