SEQUENCE LISTING

<110>   University of Southampton and BioInvent International AB
<120>   BIOLOGICAL MATERIALS AND METHODS OF USING THE SAME
          

<130>   BIOBX/P49525PC

<140>   PCT/GB2011/051572
<141>   19/08/2011

<150>   GB1013989.7
<151>   20/08/2010

<160>   106

<170>   SeqWin99

<210>   1
<211>   330
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   CH region

<400>   1
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 

Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>   2
<211>   105
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   CL Region

<400>   2
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      

Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          

Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              

Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  

Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  

His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      

Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 

<210>   3
<211>   117
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 1 VH region

<400>   3
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Glu Trp Arg Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         

Val Thr Val Ser Ser 
        115         

<210>   4
<211>   117
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 2 VH region

<400>   4
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Ala Tyr Asp Gly Ser Lys Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Glu Tyr Arg Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         

Val Thr Val Ser Ser 
        115         

<210>   5
<211>   117
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 3 VH region

<400>   5
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Ser Tyr Asp Gly Ser Asn Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Arg Trp Asn Gly Met Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         

Val Thr Val Ser Ser 
        115         

<210>   6
<211>   119
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 4 VH region

<400>   6
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Ser Tyr Asp Gly Ser Asp Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp His Ser Val Ile Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         

Thr Leu Val Thr Val Ser Ser 
        115                 

<210>   7
<211>   118
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 5 VH region

<400>   7
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Gln Leu Gly Glu Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         

Leu Val Thr Val Ser Ser 
        115             

<210>   8
<211>   117
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 6 VH region

<400>   8
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Ala Ile Ser Gly Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Gly Gly Asp Ile Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         

Val Thr Val Ser Ser 
        115         

<210>   9
<211>   117
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 7 VH region

<400>   9
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Glu Arg Arg Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         

Val Thr Val Ser Ser 
        115         

<210>   10
<211>   119
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 8 VH region

<400>   10
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp His Ser Ala Ala Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         

Thr Leu Val Thr Val Ser Ser 
        115                 

<210>   11
<211>   119
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 9 VH region

<400>   11
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Ser Trp Asp Ser Ala Ile Ile Asp Tyr Ala Gly Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Lys Asp Glu Ala Ala Ala Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         

Thr Leu Val Thr Val Ser Ser 
        115                 

<210>   12
<211>   117
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 10 VH region

<400>   12
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              

Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Glu Leu Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         

Val Thr Val Ser Ser 
        115         

<210>   13
<211>   118
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 11 VH region

<400>   13
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Glu Phe Gly Tyr Ile Ile Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         

Leu Val Thr Val Ser Ser 
        115             

<210>   14
<211>   117
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 12 VH region

<400>   14
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn His 
            20                  25                  30          

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Glu Thr Trp Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         

Val Thr Val Ser Ser 
        115         

<210>   15
<211>   121
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 13 VH region

<400>   15
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr 
            20                  25                  30          

Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Ser Ser Val Gly Ala Tyr Ala Asn Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         

Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210>   16
<211>   113
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 1 VL region

<400>   16
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              

Leu Ile Tyr Ser Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  

Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      

Leu Ser Gly Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         

Gly 
    

<210>   17
<211>   112
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 2 VL region

<400>   17
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Thr Thr Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  

Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      

Val Ser Gly Trp Met Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>   18
<211>   113
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 3 VL region

<400>   18
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              

Leu Ile Tyr Ala Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  

Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      

Leu Asn Gly Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         

Gly 
    

<210>   19
<211>   110
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 4 VL region

<400>   19
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          

Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              

Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn 
                85                  90                  95      

Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 

<210>   20
<211>   112
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 5 VL region

<400>   20
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              

Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  

Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser 
                85                  90                  95      

Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>   21
<211>   112
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 6 VL region

<400>   21
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Phe Gly Ala Gly 
            20                  25                  30          

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              

Leu Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  

Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      

Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>   22
<211>   110
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 7 VL region

<400>   22
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              

Leu Ile Tyr Ser Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  

Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Asp 
                85                  90                  95      

Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 

<210>   23
<211>   111
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 8 VL region

<400>   23
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          

Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              

Ile Tyr Gly Asn Ser Ile Arg Pro Ser Gly Gly Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      

Ser Ser Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     

<210>   24
<211>   113
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 9 VL region

<400>   24
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              

Leu Ile Tyr Gly Asn Thr Asp Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  

Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      

Leu Ser Gly Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         

Gly 
    

<210>   25
<211>   112
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 10 VL region

<400>   25
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              

Leu Ile Tyr Ala Asp Asp His Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  

Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser 
                85                  90                  95      

Gln Arg Ala Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>   26
<211>   111
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 11 VL region

<400>   26
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          

Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              

Ile Tyr Arg Asp Tyr Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ala Trp Asp Asp Ser Leu 
                85                  90                  95      

Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     

<210>   27
<211>   109
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 12 VL region

<400>   27
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          

Asn Ala Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              

Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr 
                85                  90                  95      

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 

<210>   28
<211>   112
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 13 VL region

<400>   28
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              

Leu Ile Tyr Gly Asp Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  

Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      

Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>   29
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 1 CDRH1

<400>   29
Asn Tyr Gly Met His 
1               5   

<210>   30
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 1 CDRH2

<400>   30
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   31
<211>   8
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 1 CDRH3

<400>   31
Glu Trp Arg Asp Ala Phe Asp Ile 
1               5               

<210>   32
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 1 CDRL1

<400>   32
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210>   33
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 1 CDRL2

<400>   33
Ser Asp Asn Gln Arg Pro Ser 
1               5           

<210>   34
<211>   12
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 1 CDRL3

<400>   34
Ala Ala Trp Asp Asp Ser Leu Ser Gly Ser Trp Val 
1               5                   10          

<210>   35
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 2 CDRH1

<400>   35
Thr Tyr Gly Met His 
1               5   

<210>   36
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 2 CDRH2

<400>   36
Val Ile Ala Tyr Asp Gly Ser Lys Lys Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   37
<211>   8
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 2 CDRH3

<400>   37
Glu Tyr Arg Asp Ala Phe Asp Ile 
1               5               

<210>   38
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 2 CDRL1

<400>   38
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210>   39
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 2 CDRL2

<400>   39
Gly Asn Ser Asn Arg Pro Ser 
1               5           

<210>   40
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 2 CDRL3

<400>   40
Ala Ala Trp Asp Asp Ser Val Ser Gly Trp Met 
1               5                   10      

<210>   41
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 3 CDRH1

<400>   41
Asn Tyr Gly Met His 
1               5   

<210>   42
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 3 CDRH2

<400>   42
Val Ile Ser Tyr Asp Gly Ser Asn Arg Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   43
<211>   8
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 3 CDRH3

<400>   43
Asp Arg Trp Asn Gly Met Asp Val 
1               5               

<210>   44
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 3 CDRL1

<400>   44
Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210>   45
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 3 CDRL2

<400>   45
Ala Asn Asn Gln Arg Pro Ser 
1               5           

<210>   46
<211>   12
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 3 CDRL3

<400>   46
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Trp Val 
1               5                   10          

<210>   47
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 4 CDRH1

<400>   47
Ser Tyr Gly Met His 
1               5   

<210>   48
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 4 CDRH2

<400>   48
Val Ile Ser Tyr Asp Gly Ser Asp Thr Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   49
<211>   10
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 4 CDRH3

<400>   49
Asp His Ser Val Ile Gly Ala Phe Asp Ile 
1               5                   10  

<210>   50
<211>   13
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 4 CDRL1

<400>   50
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              

<210>   51
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 4 CDRL2

<400>   51
Asp Asn Asn Lys Arg Pro Ser 
1               5           

<210>   52
<211>   10
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 4 CDRL3

<400>   52
Ser Ser Tyr Ala Gly Ser Asn Asn Val Val 
1               5                   10  

<210>   53
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 5 CDRH1

<400>   53
Asn Tyr Gly Met His 
1               5   

<210>   54
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 5 CDRH2

<400>   54
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   55
<211>   9
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 5 CDRH3

<400>   55
Asp Gln Leu Gly Glu Ala Phe Asp Ile 
1               5                   

<210>   56
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 5 CDRL1

<400>   56
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210>   57
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 5 CDRL2

<400>   57
Asp Asn Asn Lys Arg Pro Ser 
1               5           

<210>   58
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 5 CDRL3

<400>   58
Ala Thr Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      

<210>   59
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 6 CDRH1

<400>   59
Asp Tyr Gly Met Ser 
1               5   

<210>   60
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 6 CDRH2

<400>   60
Ala Ile Ser Gly Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   61
<211>   8
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 6 CDRH3

<400>   61
Gly Asp Ile Asp Tyr Phe Asp Tyr 
1               5               

<210>   62
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 6 CDRL1

<400>   62
Thr Gly Ser Ser Ser Asn Phe Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210>   63
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 6 CDRL2

<400>   63
Glu Asn Asn Lys Arg Pro Ser 
1               5           

<210>   64
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 6 CDRL3

<400>   64
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      

<210>   65
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 7 CDRH1

<400>   65
Ser Tyr Gly Met His 
1               5   

<210>   66
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 7 CDRH2

<400>   66
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   67
<211>   8
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 7 CDRH3

<400>   67
Glu Arg Arg Asp Ala Phe Asp Ile 
1               5               

<210>   68
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 7 CDRL1

<400>   68
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210>   69
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 7 CDRL2

<400>   69
Ser Asp Asn Gln Arg Pro Ser 
1               5           

<210>   70
<211>   9
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 7 CDRL3

<400>   70
Ala Thr Trp Asp Ser Asp Thr Pro Val 
1               5                   

<210>   71
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 8 CDRH1

<400>   71
Ser Tyr Gly Met His 
1               5   

<210>   72
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 8 CDRH2

<400>   72
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   73
<211>   10
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 8 CDRH3

<400>   73
Asp His Ser Ala Ala Gly Tyr Phe Asp Tyr 
1               5                   10  

<210>   74
<211>   13
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 8 CDRL1

<400>   74
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              

<210>   75
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 8 CDRL2

<400>   75
Gly Asn Ser Ile Arg Pro Ser 
1               5           

<210>   76
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 8 CDRL3

<400>   76
Ala Ser Trp Asp Asp Ser Leu Ser Ser Pro Val 
1               5                   10      

<210>   77
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 9 CDRH1

<400>   77
Ser Tyr Gly Met His 
1               5   

<210>   78
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 9 CDRH2

<400>   78
Gly Ile Ser Trp Asp Ser Ala Ile Ile Asp Tyr Ala Gly Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   79
<211>   10
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 9 CDRH3

<400>   79
Asp Glu Ala Ala Ala Gly Ala Phe Asp Ile 
1               5                   10  

<210>   80
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 9 CDRL1

<400>   80
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210>   81
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 9 CDRL2

<400>   81
Gly Asn Thr Asp Arg Pro Ser 
1               5           

<210>   82
<211>   12
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 9 CDRL3

<400>   82
Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val Val 
1               5                   10          

<210>   83
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 10 CDRH1

<400>   83
Ser Tyr Gly Met His 
1               5   

<210>   84
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 10 CDRH2

<400>   84
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   85
<211>   8
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 10 CDRH3

<400>   85
Glu Leu Tyr Asp Ala Phe Asp Ile 
1               5               

<210>   86
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 10 CDRL1

<400>   86
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210>   87
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 10 CDRL2

<400>   87
Ala Asp Asp His Arg Pro Ser 
1               5           

<210>   88
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 10 CDRL3

<400>   88
Ala Ser Trp Asp Asp Ser Gln Arg Ala Val Ile 
1               5                   10      

<210>   89
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 11 CDRH1

<400>   89
Ser Tyr Gly Met His 
1               5   

<210>   90
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 11 CDRH2

<400>   90
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   91
<211>   9
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 11 CDRH3

<400>   91
Glu Phe Gly Tyr Ile Ile Leu Asp Tyr 
1               5                   

<210>   92
<211>   13
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 11 CDRL1

<400>   92
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              

<210>   93
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 11 CDRL2

<400>   93
Arg Asp Tyr Glu Arg Pro Ser 
1               5           

<210>   94
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 11 CDRL3

<400>   94
Met Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      

<210>   95
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 12 CDRH1

<400>   95
Asn His Gly Met His 
1               5   

<210>   96
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 12 CDRH2

<400>   96
Val Ile Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      

Gly 
    

<210>   97
<211>   8
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 12 CDRH3

<400>   97
Glu Thr Trp Asp Ala Phe Asp Val 
1               5               

<210>   98
<211>   13
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 12 CDRL1

<400>   98
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Asn Ala Asn 
1               5                   10              

<210>   99
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 12 CDRL2

<400>   99
Asp Asn Asn Lys Arg Pro Ser 
1               5           

<210>   100
<211>   9
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 12 CDRL3

<400>   100
Gln Ala Trp Asp Ser Ser Thr Val Val 
1               5                   

<210>   101
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 13 CDRH1

<400>   101
Ser Tyr Gly Ile Ser 
1               5   

<210>   102
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 13 CDRH2

<400>   102
Gly Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    

<210>   103
<211>   12
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 13 CDRH3

<400>   103
Ser Val Gly Ala Tyr Ala Asn Asp Ala Phe Asp Ile 
1               5                   10          

<210>   104
<211>   14
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 13 CDRL1

<400>   104
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210>   105
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 13 CDRL2

<400>   105
Gly Asp Thr Asn Arg Pro Ser 
1               5           

<210>   106
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clone 13 CDRL3

<400>   106
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      

