                         SEQUENCE LISTING

<110>  Beth Israel Deaconess Medical Center
       Tsokos, George C
 
<120>  METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING LUPUS

<130>  01948/186WO2

<140>  PCT/US11/047664
<141>  2011-08-12

<150>  US 61/373,185
<151>  2010-08-12

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  2
<211>  1629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca       60

tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag      120

gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc      180

ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc      240

tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc      300

aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc      360

aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc      420

tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc      480

aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt      540

ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca      600

tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg      660

gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat      720

atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa      780

cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt      840

ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa      900

gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag      960

cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt     1020

ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc     1080

cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca     1140

accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc     1200

taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg     1260

gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta     1320

ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg     1380

aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca     1440

tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa     1500

aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa     1560

tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt     1620

attcacatc                                                             1629


<210>  3
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  4
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Ser Thr 
    210                 215                 220                 


Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu 
225                 230                 235                 240 


Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp 
                245                 250                 255     


Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe 
            260                 265                 270         


Asp His Thr Lys Gln Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His 
        275                 280                 285             


Ser Asn Pro Glu Val Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val 
    290                 295                 300                 


Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala 
305                 310                 315                 320 


His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr Pro 
                325                 330                 335     


His Ser Thr Ser Thr Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu 
            340                 345                 350         


Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly 
        355                 360                 365             


Tyr Arg Gln Thr Pro Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala 
    370                 375                 380                 


Ala Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro 
385                 390                 395                 400 


Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His 
                405                 410                 415     


Pro Met Gly Arg Gly His Gln Ala Gly Arg Arg Met Asp Met Asp Ser 
            420                 425                 430         


Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu 
        435                 440                 445             


Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln 
    450                 455                 460                 


Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp 
465                 470                 475                 480 


Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp 
                485                 490                 495     


Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr 
            500                 505                 510         


Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg 
        515                 520                 525             


Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr 
    530                 535                 540                 


Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser 
545                 550                 555                 560 


Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His 
                565                 570                 575     


Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala 
            580                 585                 590         


Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu 
        595                 600                 605             


Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys 
    610                 615                 620                 


Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val 
625                 630                 635                 640 


Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu 
                645                 650                 655     


Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys 
            660                 665                 670         


Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg 
        675                 680                 685             


Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
    690                 695                 


<210>  5
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Met 
    210                 215                 220                 


Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn Thr 
225                 230                 235                 240 


Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr Thr 
                245                 250                 255     


Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu 
            260                 265                 270         


Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser Asn Arg 
        275                 280                 285             


Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
    290                 295                 300                 


Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
305                 310                 315                 320 


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
                325                 330                 335     


Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
            340                 345                 350         


Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 
        355                 360                 365             


Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
    370                 375                 380                 


Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 
385                 390                 395                 400 


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
                405                 410                 415     


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
            420                 425                 430         


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
        435                 440                 445             


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
    450                 455                 460                 


Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 
465                 470                 475                 480 


Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
                485                 490             


<210>  6
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 
    210                 215                 220                 


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
                245                 250                 255     


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn 
    290                 295                 300                 


Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly 
305                 310                 315                 320 


Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser 
                325                 330                 335     


Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu 
            340                 345                 350         


Gln Asn Val Asp Met Lys Ile Gly Val 
        355                 360     


<210>  7
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Ser Leu His 
65                  70                  75                  80  


Cys Ser Gln Gln Ser Lys Lys Val Trp Ala Glu Glu Lys Ala Ser Asp 
                85                  90                  95      


Gln Gln Trp Gln Trp Ser Cys Gly Gly Gln Lys Ala Lys Trp Thr Gln 
            100                 105                 110         


Arg Arg Gly Gln Gln Val Ser Gly Asn Gly Ala Phe Gly Glu Gln Gly 
        115                 120                 125             


Val Val Arg Asn Ser Arg Pro Val Tyr Asp Ser 
    130                 135                 


<210>  8
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Asn Arg 
    210                 215                 220                 


Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly Ser 
225                 230                 235                 240 


Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys Glu 
                245                 250                 255     


Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe Gly 
            260                 265                 270         


Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg Ser 
        275                 280                 285             


Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr 
    290                 295                 300                 


Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly 
305                 310                 315                 320 


Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu 
                325                 330                 335     


Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
            340                 345                 350         


Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
        355                 360                 365             


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
    370                 375                 380                 


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
385                 390                 395                 400 


Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 
                405                 410                 415     


Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val 
            420                 425                 


<210>  9
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg His 
    210                 215                 220                 


Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile 
225                 230                 235                 240 


Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu 
                245                 250                 255     


Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg 
            260                 265                 270         


Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala 
        275                 280                 285             


Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser 
    290                 295                 300                 


Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp 
305                 310                 315                 320 


Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met 
                325                 330                 335     


Lys Ile Gly Val 
            340 


<210>  10
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Arg Asp 
    210                 215                 220                 


Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser 
225                 230                 235                 240 


Glu Ser Asp Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr 
                245                 250                 255     


Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile 
            260                 265                 270         


Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala 
        275                 280                 285             


Val Asn Ser Arg Arg Ser 
    290                 


<210>  11
<211>  5748
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcaggta tgggttcata gaagggcacg tggtgattcc ccggatccac cccaactcca      720

tctgtgcagc aaacaacaca ggggtgtaca tcctcacatc caacacctcc cagtatgaca      780

catattgctt caatgcttca gctccacctg aagaagattg tacatcagtc acagacctgc      840

ccaatgcctt tgatggacca attaccataa ctattgttaa ccgtgatggc acccgctatg      900

tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg      960

atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt     1020

acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca     1080

cagacagaat ccctgctacc actttgatga gcactagtgc tacagcaact gagacagcaa     1140

ccaagaggca agaaacctgg gattggtttt catggttgtt tctaccatca gagtcaaaga     1200

atcatcttca cacaacaaca caaatggctg gtacgtcttc aaataccatc tcagcaggct     1260

gggagccaaa tgaagaaaat gaagatgaaa gagacagaca cctcagtttt tctggatcag     1320

gcattgatga tgatgaagat tttatctcca gcaccatttc aaccacacca cgggcttttg     1380

accacacaaa acagaaccag gactggaccc agtggaaccc aagccattca aatccggaag     1440

tgctacttca gacaaccaca aggatgactg atgtagacag aaatggcacc actgcttatg     1500

aaggaaactg gaacccagaa gcacaccctc ccctcattca ccatgagcat catgaggaag     1560

aagagacccc acattctaca agcacaatcc aggcaactcc tagtagtaca acggaagaaa     1620

cagctaccca gaaggaacag tggtttggca acagatggca tgagggatat cgccaaacac     1680

ccaaagaaga ctcccattcg acaacaggga cagctgcagc ctcagctcat accagccatc     1740

caatgcaagg aaggacaaca ccaagcccag aggacagttc ctggactgat ttcttcaacc     1800

caatctcaca ccccatggga cgaggtcatc aagcaggaag aaggatggat atggactcca     1860

gtcatagtat aacgcttcag cctactgcaa atccaaacac aggtttggtg gaagatttgg     1920

acaggacagg acctctttca atgacaacgc agcagagtaa ttctcagagc ttctctacat     1980

cacatgaagg cttggaagaa gataaagacc atccaacaac ttctactctg acatcaagca     2040

ataggaatga tgtcacaggt ggaagaagag acccaaatca ttctgaaggc tcaactactt     2100

tactggaagg ttatacctct cattacccac acacgaagga aagcaggacc ttcatcccag     2160

tgacctcagc taagactggg tcctttggag ttactgcagt tactgttgga gattccaact     2220

ctaatgtcaa tcgttcctta tcaggagacc aagacacatt ccaccccagt ggggggtccc     2280

ataccactca tggatctgaa tcagatggac actcacatgg gagtcaagaa ggtggagcaa     2340

acacaacctc tggtcctata aggacacccc aaattccaga atggctgatc atcttggcat     2400

ccctcttggc cttggctttg attcttgcag tttgcattgc agtcaacagt cgaagaaggt     2460

gtgggcagaa gaaaaagcta gtgatcaaca gtggcaatgg agctgtggag gacagaaagc     2520

caagtggact caacggagag gccagcaagt ctcaggaaat ggtgcatttg gtgaacaagg     2580

agtcgtcaga aactccagac cagtttatga cagctgatga gacaaggaac ctgcagaatg     2640

tggacatgaa gattggggtg taacacctac accattatct tggaaagaaa caaccgttgg     2700

aaacataacc attacaggga gctgggacac ttaacagatg caatgtgcta ctgattgttt     2760

cattgcgaat cttttttagc ataaaatttt ctactctttt tgttttttgt gttttgttct     2820

ttaaagtcag gtccaatttg taaaaacagc attgctttct gaaattaggg cccaattaat     2880

aatcagcaag aatttgatcg ttccagttcc cacttggagg cctttcatcc ctcgggtgtg     2940

ctatggatgg cttctaacaa aaactacaca tatgtattcc tgatcgccaa cctttccccc     3000

accagctaag gacatttccc agggttaata gggcctggtc cctgggagga aatttgaatg     3060

ggtccatttt gcccttccat agcctaatcc ctgggcattg ctttccactg aggttggggg     3120

ttggggtgta ctagttacac atcttcaaca gaccccctct agaaattttt cagatgcttc     3180

tgggagacac ccaaagggtg aagctattta tctgtagtaa actatttatc tgtgtttttg     3240

aaatattaaa ccctggatca gtcctttgat cagtataatt ttttaaagtt actttgtcag     3300

aggcacaaaa gggtttaaac tgattcataa taaatatctg tacttcttcg atcttcacct     3360

tttgtgctgt gattcttcag tttctaaacc agcactgtct gggtccctac aatgtatcag     3420

gaagagctga gaatggtaag gagactcttc taagtcttca tctcagagac cctgagttcc     3480

cactcagacc cactcagcca aatctcatgg aagaccaagg agggcagcac tgtttttgtt     3540

ttttgttttt tgtttttttt ttttgacact gtccaaaggt tttccatcct gtcctggaat     3600

cagagttgga agctgaggag cttcagcctc ttttatggtt taatggccac ctgttctctc     3660

ctgtgaaagg ctttgcaaag tcacattaag tttgcatgac ctgttatccc tggggcccta     3720

tttcatagag gctggcccta ttagtgattt ccaaaaacaa tatggaagtg ccttttgatg     3780

tcttacaata agagaagaag ccaatggaaa tgaaagagat tggcaaaggg gaaggatgat     3840

gccatgtaga tcctgtttga catttttatg gctgtatttg taaacttaaa cacaccagtg     3900

tctgttcttg atgcagttgc tatttaggat gagttaagtg cctggggagt ccctcaaaag     3960

gttaaaggga ttcccatcat tggaatctta tcaccagata ggcaagttta tgaccaaaca     4020

agagagtact ggctttatcc tctaacctca tattttctcc cacttggcaa gtcctttgtg     4080

gcatttattc atcagtcagg gtgtccgatt ggtcctagaa cttccaaagg ctgcttgtca     4140

tagaagccat tgcatctata aagcaacggc tcctgttaaa tggtatctcc tttctgaggc     4200

tcctactaaa agtcatttgt tacctaaact tatgtgctta acaggcaatg cttctcagac     4260

cacaaagcag aaagaagaag aaaagctcct gactaaatca gggctgggct tagacagagt     4320

tgatctgtag aatatcttta aaggagagat gtcaactttc tgcactattc ccagcctctg     4380

ctcctccctg tctaccctct cccctccctc tctccctcca cttcacccca caatcttgaa     4440

aaacttcctt tctcttctgt gaacatcatt ggccagatcc attttcagtg gtctggattt     4500

ctttttattt tcttttcaac ttgaaagaaa ctggacatta ggccactatg tgttgttact     4560

gccactagtg ttcaagtgcc tcttgttttc ccagagattt cctgggtctg ccagaggccc     4620

agacaggctc actcaagctc tttaactgaa aagcaacaag ccactccagg acaaggttca     4680

aaatggttac aacagcctct acctgtcgcc ccagggagaa aggggtagtg atacaagtct     4740

catagccaga gatggttttc cactccttct agatattccc aaaaagaggc tgagacagga     4800

ggttattttc aattttattt tggaattaaa tacttttttc cctttattac tgttgtagtc     4860

cctcacttgg atatacctct gttttcacga tagaaataag ggaggtctag agcttctatt     4920

ccttggccat tgtcaacgga gagctggcca agtcttcaca aacccttgca acattgcctg     4980

aagtttatgg aataagatgt attctcactc ccttgatctc aagggcgtaa ctctggaagc     5040

acagcttgac tacacgtcat ttttaccaat gattttcagg tgacctgggc taagtcattt     5100

aaactgggtc tttataaaag taaaaggcca acatttaatt attttgcaaa gcaacctaag     5160

agctaaagat gtaatttttc ttgcaattgt aaatcttttg tgtctcctga agacttccct     5220

taaaattagc tctgagtgaa aaatcaaaag agacaaaaga catcttcgaa tccatatttc     5280

aagcctggta gaattggctt ttctagcaga acctttccaa aagttttata ttgagattca     5340

taacaacacc aagaattgat tttgtagcca acattcattc aatactgtta tatcagagga     5400

gtaggagaga ggaaacattt gacttatctg gaaaagcaaa atgtacttaa gaataagaat     5460

aacatggtcc attcaccttt atgttataga tatgtctttg tgtaaatcat ttgttttgag     5520

ttttcaaaga atagcccatt gttcattctt gtgctgtaca atgaccactg ttattgttac     5580

tttgactttt cagagcacac ccttcctctg gtttttgtat atttattgat ggatcaataa     5640

taatgaggaa agcatgatat gtatattgct gagttgaaag cacttattgg aaaatattaa     5700

aaggctaaca ttaaaagact aaaggaaaca gaaaaaaaaa aaaaaaaa                  5748


<210>  12
<211>  5619
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcaggta tgggttcata gaagggcacg tggtgattcc ccggatccac cccaactcca      720

tctgtgcagc aaacaacaca ggggtgtaca tcctcacatc caacacctcc cagtatgaca      780

catattgctt caatgcttca gctccacctg aagaagattg tacatcagtc acagacctgc      840

ccaatgcctt tgatggacca attaccataa ctattgttaa ccgtgatggc acccgctatg      900

tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg      960

atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt     1020

acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca     1080

cagacagaat ccctgctacc agtacgtctt caaataccat ctcagcaggc tgggagccaa     1140

atgaagaaaa tgaagatgaa agagacagac acctcagttt ttctggatca ggcattgatg     1200

atgatgaaga ttttatctcc agcaccattt caaccacacc acgggctttt gaccacacaa     1260

aacagaacca ggactggacc cagtggaacc caagccattc aaatccggaa gtgctacttc     1320

agacaaccac aaggatgact gatgtagaca gaaatggcac cactgcttat gaaggaaact     1380

ggaacccaga agcacaccct cccctcattc accatgagca tcatgaggaa gaagagaccc     1440

cacattctac aagcacaatc caggcaactc ctagtagtac aacggaagaa acagctaccc     1500

agaaggaaca gtggtttggc aacagatggc atgagggata tcgccaaaca cccaaagaag     1560

actcccattc gacaacaggg acagctgcag cctcagctca taccagccat ccaatgcaag     1620

gaaggacaac accaagccca gaggacagtt cctggactga tttcttcaac ccaatctcac     1680

accccatggg acgaggtcat caagcaggaa gaaggatgga tatggactcc agtcatagta     1740

taacgcttca gcctactgca aatccaaaca caggtttggt ggaagatttg gacaggacag     1800

gacctctttc aatgacaacg cagcagagta attctcagag cttctctaca tcacatgaag     1860

gcttggaaga agataaagac catccaacaa cttctactct gacatcaagc aataggaatg     1920

atgtcacagg tggaagaaga gacccaaatc attctgaagg ctcaactact ttactggaag     1980

gttatacctc tcattaccca cacacgaagg aaagcaggac cttcatccca gtgacctcag     2040

ctaagactgg gtcctttgga gttactgcag ttactgttgg agattccaac tctaatgtca     2100

atcgttcctt atcaggagac caagacacat tccaccccag tggggggtcc cataccactc     2160

atggatctga atcagatgga cactcacatg ggagtcaaga aggtggagca aacacaacct     2220

ctggtcctat aaggacaccc caaattccag aatggctgat catcttggca tccctcttgg     2280

ccttggcttt gattcttgca gtttgcattg cagtcaacag tcgaagaagg tgtgggcaga     2340

agaaaaagct agtgatcaac agtggcaatg gagctgtgga ggacagaaag ccaagtggac     2400

tcaacggaga ggccagcaag tctcaggaaa tggtgcattt ggtgaacaag gagtcgtcag     2460

aaactccaga ccagtttatg acagctgatg agacaaggaa cctgcagaat gtggacatga     2520

agattggggt gtaacaccta caccattatc ttggaaagaa acaaccgttg gaaacataac     2580

cattacaggg agctgggaca cttaacagat gcaatgtgct actgattgtt tcattgcgaa     2640

tcttttttag cataaaattt tctactcttt ttgttttttg tgttttgttc tttaaagtca     2700

ggtccaattt gtaaaaacag cattgctttc tgaaattagg gcccaattaa taatcagcaa     2760

gaatttgatc gttccagttc ccacttggag gcctttcatc cctcgggtgt gctatggatg     2820

gcttctaaca aaaactacac atatgtattc ctgatcgcca acctttcccc caccagctaa     2880

ggacatttcc cagggttaat agggcctggt ccctgggagg aaatttgaat gggtccattt     2940

tgcccttcca tagcctaatc cctgggcatt gctttccact gaggttgggg gttggggtgt     3000

actagttaca catcttcaac agaccccctc tagaaatttt tcagatgctt ctgggagaca     3060

cccaaagggt gaagctattt atctgtagta aactatttat ctgtgttttt gaaatattaa     3120

accctggatc agtcctttga tcagtataat tttttaaagt tactttgtca gaggcacaaa     3180

agggtttaaa ctgattcata ataaatatct gtacttcttc gatcttcacc ttttgtgctg     3240

tgattcttca gtttctaaac cagcactgtc tgggtcccta caatgtatca ggaagagctg     3300

agaatggtaa ggagactctt ctaagtcttc atctcagaga ccctgagttc ccactcagac     3360

ccactcagcc aaatctcatg gaagaccaag gagggcagca ctgtttttgt tttttgtttt     3420

ttgttttttt tttttgacac tgtccaaagg ttttccatcc tgtcctggaa tcagagttgg     3480

aagctgagga gcttcagcct cttttatggt ttaatggcca cctgttctct cctgtgaaag     3540

gctttgcaaa gtcacattaa gtttgcatga cctgttatcc ctggggccct atttcataga     3600

ggctggccct attagtgatt tccaaaaaca atatggaagt gccttttgat gtcttacaat     3660

aagagaagaa gccaatggaa atgaaagaga ttggcaaagg ggaaggatga tgccatgtag     3720

atcctgtttg acatttttat ggctgtattt gtaaacttaa acacaccagt gtctgttctt     3780

gatgcagttg ctatttagga tgagttaagt gcctggggag tccctcaaaa ggttaaaggg     3840

attcccatca ttggaatctt atcaccagat aggcaagttt atgaccaaac aagagagtac     3900

tggctttatc ctctaacctc atattttctc ccacttggca agtcctttgt ggcatttatt     3960

catcagtcag ggtgtccgat tggtcctaga acttccaaag gctgcttgtc atagaagcca     4020

ttgcatctat aaagcaacgg ctcctgttaa atggtatctc ctttctgagg ctcctactaa     4080

aagtcatttg ttacctaaac ttatgtgctt aacaggcaat gcttctcaga ccacaaagca     4140

gaaagaagaa gaaaagctcc tgactaaatc agggctgggc ttagacagag ttgatctgta     4200

gaatatcttt aaaggagaga tgtcaacttt ctgcactatt cccagcctct gctcctccct     4260

gtctaccctc tcccctccct ctctccctcc acttcacccc acaatcttga aaaacttcct     4320

ttctcttctg tgaacatcat tggccagatc cattttcagt ggtctggatt tctttttatt     4380

ttcttttcaa cttgaaagaa actggacatt aggccactat gtgttgttac tgccactagt     4440

gttcaagtgc ctcttgtttt cccagagatt tcctgggtct gccagaggcc cagacaggct     4500

cactcaagct ctttaactga aaagcaacaa gccactccag gacaaggttc aaaatggtta     4560

caacagcctc tacctgtcgc cccagggaga aaggggtagt gatacaagtc tcatagccag     4620

agatggtttt ccactccttc tagatattcc caaaaagagg ctgagacagg aggttatttt     4680

caattttatt ttggaattaa atactttttt ccctttatta ctgttgtagt ccctcacttg     4740

gatatacctc tgttttcacg atagaaataa gggaggtcta gagcttctat tccttggcca     4800

ttgtcaacgg agagctggcc aagtcttcac aaacccttgc aacattgcct gaagtttatg     4860

gaataagatg tattctcact cccttgatct caagggcgta actctggaag cacagcttga     4920

ctacacgtca tttttaccaa tgattttcag gtgacctggg ctaagtcatt taaactgggt     4980

ctttataaaa gtaaaaggcc aacatttaat tattttgcaa agcaacctaa gagctaaaga     5040

tgtaattttt cttgcaattg taaatctttt gtgtctcctg aagacttccc ttaaaattag     5100

ctctgagtga aaaatcaaaa gagacaaaag acatcttcga atccatattt caagcctggt     5160

agaattggct tttctagcag aacctttcca aaagttttat attgagattc ataacaacac     5220

caagaattga ttttgtagcc aacattcatt caatactgtt atatcagagg agtaggagag     5280

aggaaacatt tgacttatct ggaaaagcaa aatgtactta agaataagaa taacatggtc     5340

cattcacctt tatgttatag atatgtcttt gtgtaaatca tttgttttga gttttcaaag     5400

aatagcccat tgttcattct tgtgctgtac aatgaccact gttattgtta ctttgacttt     5460

tcagagcaca cccttcctct ggtttttgta tatttattga tggatcaata ataatgagga     5520

aagcatgata tgtatattgc tgagttgaaa gcacttattg gaaaatatta aaaggctaac     5580

attaaaagac taaaggaaac agaaaaaaaa aaaaaaaaa                            5619


<210>  13
<211>  5001
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcaggta tgggttcata gaagggcacg tggtgattcc ccggatccac cccaactcca      720

tctgtgcagc aaacaacaca ggggtgtaca tcctcacatc caacacctcc cagtatgaca      780

catattgctt caatgcttca gctccacctg aagaagattg tacatcagtc acagacctgc      840

ccaatgcctt tgatggacca attaccataa ctattgttaa ccgtgatggc acccgctatg      900

tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg      960

atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt     1020

acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca     1080

cagacagaat ccctgctacc aatatggact ccagtcatag tataacgctt cagcctactg     1140

caaatccaaa cacaggtttg gtggaagatt tggacaggac aggacctctt tcaatgacaa     1200

cgcagcagag taattctcag agcttctcta catcacatga aggcttggaa gaagataaag     1260

accatccaac aacttctact ctgacatcaa gcaataggaa tgatgtcaca ggtggaagaa     1320

gagacccaaa tcattctgaa ggctcaacta ctttactgga aggttatacc tctcattacc     1380

cacacacgaa ggaaagcagg accttcatcc cagtgacctc agctaagact gggtcctttg     1440

gagttactgc agttactgtt ggagattcca actctaatgt caatcgttcc ttatcaggag     1500

accaagacac attccacccc agtggggggt cccataccac tcatggatct gaatcagatg     1560

gacactcaca tgggagtcaa gaaggtggag caaacacaac ctctggtcct ataaggacac     1620

cccaaattcc agaatggctg atcatcttgg catccctctt ggccttggct ttgattcttg     1680

cagtttgcat tgcagtcaac agtcgaagaa ggtgtgggca gaagaaaaag ctagtgatca     1740

acagtggcaa tggagctgtg gaggacagaa agccaagtgg actcaacgga gaggccagca     1800

agtctcagga aatggtgcat ttggtgaaca aggagtcgtc agaaactcca gaccagttta     1860

tgacagctga tgagacaagg aacctgcaga atgtggacat gaagattggg gtgtaacacc     1920

tacaccatta tcttggaaag aaacaaccgt tggaaacata accattacag ggagctggga     1980

cacttaacag atgcaatgtg ctactgattg tttcattgcg aatctttttt agcataaaat     2040

tttctactct ttttgttttt tgtgttttgt tctttaaagt caggtccaat ttgtaaaaac     2100

agcattgctt tctgaaatta gggcccaatt aataatcagc aagaatttga tcgttccagt     2160

tcccacttgg aggcctttca tccctcgggt gtgctatgga tggcttctaa caaaaactac     2220

acatatgtat tcctgatcgc caacctttcc cccaccagct aaggacattt cccagggtta     2280

atagggcctg gtccctggga ggaaatttga atgggtccat tttgcccttc catagcctaa     2340

tccctgggca ttgctttcca ctgaggttgg gggttggggt gtactagtta cacatcttca     2400

acagaccccc tctagaaatt tttcagatgc ttctgggaga cacccaaagg gtgaagctat     2460

ttatctgtag taaactattt atctgtgttt ttgaaatatt aaaccctgga tcagtccttt     2520

gatcagtata attttttaaa gttactttgt cagaggcaca aaagggttta aactgattca     2580

taataaatat ctgtacttct tcgatcttca ccttttgtgc tgtgattctt cagtttctaa     2640

accagcactg tctgggtccc tacaatgtat caggaagagc tgagaatggt aaggagactc     2700

ttctaagtct tcatctcaga gaccctgagt tcccactcag acccactcag ccaaatctca     2760

tggaagacca aggagggcag cactgttttt gttttttgtt ttttgttttt tttttttgac     2820

actgtccaaa ggttttccat cctgtcctgg aatcagagtt ggaagctgag gagcttcagc     2880

ctcttttatg gtttaatggc cacctgttct ctcctgtgaa aggctttgca aagtcacatt     2940

aagtttgcat gacctgttat ccctggggcc ctatttcata gaggctggcc ctattagtga     3000

tttccaaaaa caatatggaa gtgccttttg atgtcttaca ataagagaag aagccaatgg     3060

aaatgaaaga gattggcaaa ggggaaggat gatgccatgt agatcctgtt tgacattttt     3120

atggctgtat ttgtaaactt aaacacacca gtgtctgttc ttgatgcagt tgctatttag     3180

gatgagttaa gtgcctgggg agtccctcaa aaggttaaag ggattcccat cattggaatc     3240

ttatcaccag ataggcaagt ttatgaccaa acaagagagt actggcttta tcctctaacc     3300

tcatattttc tcccacttgg caagtccttt gtggcattta ttcatcagtc agggtgtccg     3360

attggtccta gaacttccaa aggctgcttg tcatagaagc cattgcatct ataaagcaac     3420

ggctcctgtt aaatggtatc tcctttctga ggctcctact aaaagtcatt tgttacctaa     3480

acttatgtgc ttaacaggca atgcttctca gaccacaaag cagaaagaag aagaaaagct     3540

cctgactaaa tcagggctgg gcttagacag agttgatctg tagaatatct ttaaaggaga     3600

gatgtcaact ttctgcacta ttcccagcct ctgctcctcc ctgtctaccc tctcccctcc     3660

ctctctccct ccacttcacc ccacaatctt gaaaaacttc ctttctcttc tgtgaacatc     3720

attggccaga tccattttca gtggtctgga tttcttttta ttttcttttc aacttgaaag     3780

aaactggaca ttaggccact atgtgttgtt actgccacta gtgttcaagt gcctcttgtt     3840

ttcccagaga tttcctgggt ctgccagagg cccagacagg ctcactcaag ctctttaact     3900

gaaaagcaac aagccactcc aggacaaggt tcaaaatggt tacaacagcc tctacctgtc     3960

gccccaggga gaaaggggta gtgatacaag tctcatagcc agagatggtt ttccactcct     4020

tctagatatt cccaaaaaga ggctgagaca ggaggttatt ttcaatttta ttttggaatt     4080

aaatactttt ttccctttat tactgttgta gtccctcact tggatatacc tctgttttca     4140

cgatagaaat aagggaggtc tagagcttct attccttggc cattgtcaac ggagagctgg     4200

ccaagtcttc acaaaccctt gcaacattgc ctgaagttta tggaataaga tgtattctca     4260

ctcccttgat ctcaagggcg taactctgga agcacagctt gactacacgt catttttacc     4320

aatgattttc aggtgacctg ggctaagtca tttaaactgg gtctttataa aagtaaaagg     4380

ccaacattta attattttgc aaagcaacct aagagctaaa gatgtaattt ttcttgcaat     4440

tgtaaatctt ttgtgtctcc tgaagacttc ccttaaaatt agctctgagt gaaaaatcaa     4500

aagagacaaa agacatcttc gaatccatat ttcaagcctg gtagaattgg cttttctagc     4560

agaacctttc caaaagtttt atattgagat tcataacaac accaagaatt gattttgtag     4620

ccaacattca ttcaatactg ttatatcaga ggagtaggag agaggaaaca tttgacttat     4680

ctggaaaagc aaaatgtact taagaataag aataacatgg tccattcacc tttatgttat     4740

agatatgtct ttgtgtaaat catttgtttt gagttttcaa agaatagccc attgttcatt     4800

cttgtgctgt acaatgacca ctgttattgt tactttgact tttcagagca cacccttcct     4860

ctggtttttg tatatttatt gatggatcaa taataatgag gaaagcatga tatgtatatt     4920

gctgagttga aagcacttat tggaaaatat taaaaggcta acattaaaag actaaaggaa     4980

acagaaaaaa aaaaaaaaaa a                                               5001


<210>  14
<211>  4605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcaggta tgggttcata gaagggcacg tggtgattcc ccggatccac cccaactcca      720

tctgtgcagc aaacaacaca ggggtgtaca tcctcacatc caacacctcc cagtatgaca      780

catattgctt caatgcttca gctccacctg aagaagattg tacatcagtc acagacctgc      840

ccaatgcctt tgatggacca attaccataa ctattgttaa ccgtgatggc acccgctatg      900

tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg      960

atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt     1020

acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca     1080

cagacagaat ccctgctacc agagaccaag acacattcca ccccagtggg gggtcccata     1140

ccactcatgg atctgaatca gatggacact cacatgggag tcaagaaggt ggagcaaaca     1200

caacctctgg tcctataagg acaccccaaa ttccagaatg gctgatcatc ttggcatccc     1260

tcttggcctt ggctttgatt cttgcagttt gcattgcagt caacagtcga agaaggtgtg     1320

ggcagaagaa aaagctagtg atcaacagtg gcaatggagc tgtggaggac agaaagccaa     1380

gtggactcaa cggagaggcc agcaagtctc aggaaatggt gcatttggtg aacaaggagt     1440

cgtcagaaac tccagaccag tttatgacag ctgatgagac aaggaacctg cagaatgtgg     1500

acatgaagat tggggtgtaa cacctacacc attatcttgg aaagaaacaa ccgttggaaa     1560

cataaccatt acagggagct gggacactta acagatgcaa tgtgctactg attgtttcat     1620

tgcgaatctt ttttagcata aaattttcta ctctttttgt tttttgtgtt ttgttcttta     1680

aagtcaggtc caatttgtaa aaacagcatt gctttctgaa attagggccc aattaataat     1740

cagcaagaat ttgatcgttc cagttcccac ttggaggcct ttcatccctc gggtgtgcta     1800

tggatggctt ctaacaaaaa ctacacatat gtattcctga tcgccaacct ttcccccacc     1860

agctaaggac atttcccagg gttaataggg cctggtccct gggaggaaat ttgaatgggt     1920

ccattttgcc cttccatagc ctaatccctg ggcattgctt tccactgagg ttgggggttg     1980

gggtgtacta gttacacatc ttcaacagac cccctctaga aatttttcag atgcttctgg     2040

gagacaccca aagggtgaag ctatttatct gtagtaaact atttatctgt gtttttgaaa     2100

tattaaaccc tggatcagtc ctttgatcag tataattttt taaagttact ttgtcagagg     2160

cacaaaaggg tttaaactga ttcataataa atatctgtac ttcttcgatc ttcacctttt     2220

gtgctgtgat tcttcagttt ctaaaccagc actgtctggg tccctacaat gtatcaggaa     2280

gagctgagaa tggtaaggag actcttctaa gtcttcatct cagagaccct gagttcccac     2340

tcagacccac tcagccaaat ctcatggaag accaaggagg gcagcactgt ttttgttttt     2400

tgttttttgt tttttttttt tgacactgtc caaaggtttt ccatcctgtc ctggaatcag     2460

agttggaagc tgaggagctt cagcctcttt tatggtttaa tggccacctg ttctctcctg     2520

tgaaaggctt tgcaaagtca cattaagttt gcatgacctg ttatccctgg ggccctattt     2580

catagaggct ggccctatta gtgatttcca aaaacaatat ggaagtgcct tttgatgtct     2640

tacaataaga gaagaagcca atggaaatga aagagattgg caaaggggaa ggatgatgcc     2700

atgtagatcc tgtttgacat ttttatggct gtatttgtaa acttaaacac accagtgtct     2760

gttcttgatg cagttgctat ttaggatgag ttaagtgcct ggggagtccc tcaaaaggtt     2820

aaagggattc ccatcattgg aatcttatca ccagataggc aagtttatga ccaaacaaga     2880

gagtactggc tttatcctct aacctcatat tttctcccac ttggcaagtc ctttgtggca     2940

tttattcatc agtcagggtg tccgattggt cctagaactt ccaaaggctg cttgtcatag     3000

aagccattgc atctataaag caacggctcc tgttaaatgg tatctccttt ctgaggctcc     3060

tactaaaagt catttgttac ctaaacttat gtgcttaaca ggcaatgctt ctcagaccac     3120

aaagcagaaa gaagaagaaa agctcctgac taaatcaggg ctgggcttag acagagttga     3180

tctgtagaat atctttaaag gagagatgtc aactttctgc actattccca gcctctgctc     3240

ctccctgtct accctctccc ctccctctct ccctccactt caccccacaa tcttgaaaaa     3300

cttcctttct cttctgtgaa catcattggc cagatccatt ttcagtggtc tggatttctt     3360

tttattttct tttcaacttg aaagaaactg gacattaggc cactatgtgt tgttactgcc     3420

actagtgttc aagtgcctct tgttttccca gagatttcct gggtctgcca gaggcccaga     3480

caggctcact caagctcttt aactgaaaag caacaagcca ctccaggaca aggttcaaaa     3540

tggttacaac agcctctacc tgtcgcccca gggagaaagg ggtagtgata caagtctcat     3600

agccagagat ggttttccac tccttctaga tattcccaaa aagaggctga gacaggaggt     3660

tattttcaat tttattttgg aattaaatac ttttttccct ttattactgt tgtagtccct     3720

cacttggata tacctctgtt ttcacgatag aaataaggga ggtctagagc ttctattcct     3780

tggccattgt caacggagag ctggccaagt cttcacaaac ccttgcaaca ttgcctgaag     3840

tttatggaat aagatgtatt ctcactccct tgatctcaag ggcgtaactc tggaagcaca     3900

gcttgactac acgtcatttt taccaatgat tttcaggtga cctgggctaa gtcatttaaa     3960

ctgggtcttt ataaaagtaa aaggccaaca tttaattatt ttgcaaagca acctaagagc     4020

taaagatgta atttttcttg caattgtaaa tcttttgtgt ctcctgaaga cttcccttaa     4080

aattagctct gagtgaaaaa tcaaaagaga caaaagacat cttcgaatcc atatttcaag     4140

cctggtagaa ttggcttttc tagcagaacc tttccaaaag ttttatattg agattcataa     4200

caacaccaag aattgatttt gtagccaaca ttcattcaat actgttatat cagaggagta     4260

ggagagagga aacatttgac ttatctggaa aagcaaaatg tacttaagaa taagaataac     4320

atggtccatt cacctttatg ttatagatat gtctttgtgt aaatcatttg ttttgagttt     4380

tcaaagaata gcccattgtt cattcttgtg ctgtacaatg accactgtta ttgttacttt     4440

gacttttcag agcacaccct tcctctggtt tttgtatatt tattgatgga tcaataataa     4500

tgaggaaagc atgatatgta tattgctgag ttgaaagcac ttattggaaa atattaaaag     4560

gctaacatta aaagactaaa ggaaacagaa aaaaaaaaaa aaaaa                     4605


<210>  15
<211>  3985
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcagttt gcattgcagt caacagtcga agaaggtgtg ggcagaagaa aaagctagtg      720

atcaacagtg gcaatggagc tgtggaggac agaaagccaa gtggactcaa cggagaggcc      780

agcaagtctc aggaaatggt gcatttggtg aacaaggagt cgtcagaaac tccagaccag      840

tttatgacag ctgatgagac aaggaacctg cagaatgtgg acatgaagat tggggtgtaa      900

cacctacacc attatcttgg aaagaaacaa ccgttggaaa cataaccatt acagggagct      960

gggacactta acagatgcaa tgtgctactg attgtttcat tgcgaatctt ttttagcata     1020

aaattttcta ctctttttgt tttttgtgtt ttgttcttta aagtcaggtc caatttgtaa     1080

aaacagcatt gctttctgaa attagggccc aattaataat cagcaagaat ttgatcgttc     1140

cagttcccac ttggaggcct ttcatccctc gggtgtgcta tggatggctt ctaacaaaaa     1200

ctacacatat gtattcctga tcgccaacct ttcccccacc agctaaggac atttcccagg     1260

gttaataggg cctggtccct gggaggaaat ttgaatgggt ccattttgcc cttccatagc     1320

ctaatccctg ggcattgctt tccactgagg ttgggggttg gggtgtacta gttacacatc     1380

ttcaacagac cccctctaga aatttttcag atgcttctgg gagacaccca aagggtgaag     1440

ctatttatct gtagtaaact atttatctgt gtttttgaaa tattaaaccc tggatcagtc     1500

ctttgatcag tataattttt taaagttact ttgtcagagg cacaaaaggg tttaaactga     1560

ttcataataa atatctgtac ttcttcgatc ttcacctttt gtgctgtgat tcttcagttt     1620

ctaaaccagc actgtctggg tccctacaat gtatcaggaa gagctgagaa tggtaaggag     1680

actcttctaa gtcttcatct cagagaccct gagttcccac tcagacccac tcagccaaat     1740

ctcatggaag accaaggagg gcagcactgt ttttgttttt tgttttttgt tttttttttt     1800

tgacactgtc caaaggtttt ccatcctgtc ctggaatcag agttggaagc tgaggagctt     1860

cagcctcttt tatggtttaa tggccacctg ttctctcctg tgaaaggctt tgcaaagtca     1920

cattaagttt gcatgacctg ttatccctgg ggccctattt catagaggct ggccctatta     1980

gtgatttcca aaaacaatat ggaagtgcct tttgatgtct tacaataaga gaagaagcca     2040

atggaaatga aagagattgg caaaggggaa ggatgatgcc atgtagatcc tgtttgacat     2100

ttttatggct gtatttgtaa acttaaacac accagtgtct gttcttgatg cagttgctat     2160

ttaggatgag ttaagtgcct ggggagtccc tcaaaaggtt aaagggattc ccatcattgg     2220

aatcttatca ccagataggc aagtttatga ccaaacaaga gagtactggc tttatcctct     2280

aacctcatat tttctcccac ttggcaagtc ctttgtggca tttattcatc agtcagggtg     2340

tccgattggt cctagaactt ccaaaggctg cttgtcatag aagccattgc atctataaag     2400

caacggctcc tgttaaatgg tatctccttt ctgaggctcc tactaaaagt catttgttac     2460

ctaaacttat gtgcttaaca ggcaatgctt ctcagaccac aaagcagaaa gaagaagaaa     2520

agctcctgac taaatcaggg ctgggcttag acagagttga tctgtagaat atctttaaag     2580

gagagatgtc aactttctgc actattccca gcctctgctc ctccctgtct accctctccc     2640

ctccctctct ccctccactt caccccacaa tcttgaaaaa cttcctttct cttctgtgaa     2700

catcattggc cagatccatt ttcagtggtc tggatttctt tttattttct tttcaacttg     2760

aaagaaactg gacattaggc cactatgtgt tgttactgcc actagtgttc aagtgcctct     2820

tgttttccca gagatttcct gggtctgcca gaggcccaga caggctcact caagctcttt     2880

aactgaaaag caacaagcca ctccaggaca aggttcaaaa tggttacaac agcctctacc     2940

tgtcgcccca gggagaaagg ggtagtgata caagtctcat agccagagat ggttttccac     3000

tccttctaga tattcccaaa aagaggctga gacaggaggt tattttcaat tttattttgg     3060

aattaaatac ttttttccct ttattactgt tgtagtccct cacttggata tacctctgtt     3120

ttcacgatag aaataaggga ggtctagagc ttctattcct tggccattgt caacggagag     3180

ctggccaagt cttcacaaac ccttgcaaca ttgcctgaag tttatggaat aagatgtatt     3240

ctcactccct tgatctcaag ggcgtaactc tggaagcaca gcttgactac acgtcatttt     3300

taccaatgat tttcaggtga cctgggctaa gtcatttaaa ctgggtcttt ataaaagtaa     3360

aaggccaaca tttaattatt ttgcaaagca acctaagagc taaagatgta atttttcttg     3420

caattgtaaa tcttttgtgt ctcctgaaga cttcccttaa aattagctct gagtgaaaaa     3480

tcaaaagaga caaaagacat cttcgaatcc atatttcaag cctggtagaa ttggcttttc     3540

tagcagaacc tttccaaaag ttttatattg agattcataa caacaccaag aattgatttt     3600

gtagccaaca ttcattcaat actgttatat cagaggagta ggagagagga aacatttgac     3660

ttatctggaa aagcaaaatg tacttaagaa taagaataac atggtccatt cacctttatg     3720

ttatagatat gtctttgtgt aaatcatttg ttttgagttt tcaaagaata gcccattgtt     3780

cattcttgtg ctgtacaatg accactgtta ttgttacttt gacttttcag agcacaccct     3840

tcctctggtt tttgtatatt tattgatgga tcaataataa tgaggaaagc atgatatgta     3900

tattgctgag ttgaaagcac ttattggaaa atattaaaag gctaacatta aaagactaaa     3960

ggaaacagaa aaaaaaaaaa aaaaa                                           3985


<210>  16
<211>  4809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcaggta tgggttcata gaagggcacg tggtgattcc ccggatccac cccaactcca      720

tctgtgcagc aaacaacaca ggggtgtaca tcctcacatc caacacctcc cagtatgaca      780

catattgctt caatgcttca gctccacctg aagaagattg tacatcagtc acagacctgc      840

ccaatgcctt tgatggacca attaccataa ctattgttaa ccgtgatggc acccgctatg      900

tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg      960

atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt     1020

acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca     1080

cagacagaat ccctgctacc aataggaatg atgtcacagg tggaagaaga gacccaaatc     1140

attctgaagg ctcaactact ttactggaag gttatacctc tcattaccca cacacgaagg     1200

aaagcaggac cttcatccca gtgacctcag ctaagactgg gtcctttgga gttactgcag     1260

ttactgttgg agattccaac tctaatgtca atcgttcctt atcaggagac caagacacat     1320

tccaccccag tggggggtcc cataccactc atggatctga atcagatgga cactcacatg     1380

ggagtcaaga aggtggagca aacacaacct ctggtcctat aaggacaccc caaattccag     1440

aatggctgat catcttggca tccctcttgg ccttggcttt gattcttgca gtttgcattg     1500

cagtcaacag tcgaagaagg tgtgggcaga agaaaaagct agtgatcaac agtggcaatg     1560

gagctgtgga ggacagaaag ccaagtggac tcaacggaga ggccagcaag tctcaggaaa     1620

tggtgcattt ggtgaacaag gagtcgtcag aaactccaga ccagtttatg acagctgatg     1680

agacaaggaa cctgcagaat gtggacatga agattggggt gtaacaccta caccattatc     1740

ttggaaagaa acaaccgttg gaaacataac cattacaggg agctgggaca cttaacagat     1800

gcaatgtgct actgattgtt tcattgcgaa tcttttttag cataaaattt tctactcttt     1860

ttgttttttg tgttttgttc tttaaagtca ggtccaattt gtaaaaacag cattgctttc     1920

tgaaattagg gcccaattaa taatcagcaa gaatttgatc gttccagttc ccacttggag     1980

gcctttcatc cctcgggtgt gctatggatg gcttctaaca aaaactacac atatgtattc     2040

ctgatcgcca acctttcccc caccagctaa ggacatttcc cagggttaat agggcctggt     2100

ccctgggagg aaatttgaat gggtccattt tgcccttcca tagcctaatc cctgggcatt     2160

gctttccact gaggttgggg gttggggtgt actagttaca catcttcaac agaccccctc     2220

tagaaatttt tcagatgctt ctgggagaca cccaaagggt gaagctattt atctgtagta     2280

aactatttat ctgtgttttt gaaatattaa accctggatc agtcctttga tcagtataat     2340

tttttaaagt tactttgtca gaggcacaaa agggtttaaa ctgattcata ataaatatct     2400

gtacttcttc gatcttcacc ttttgtgctg tgattcttca gtttctaaac cagcactgtc     2460

tgggtcccta caatgtatca ggaagagctg agaatggtaa ggagactctt ctaagtcttc     2520

atctcagaga ccctgagttc ccactcagac ccactcagcc aaatctcatg gaagaccaag     2580

gagggcagca ctgtttttgt tttttgtttt ttgttttttt tttttgacac tgtccaaagg     2640

ttttccatcc tgtcctggaa tcagagttgg aagctgagga gcttcagcct cttttatggt     2700

ttaatggcca cctgttctct cctgtgaaag gctttgcaaa gtcacattaa gtttgcatga     2760

cctgttatcc ctggggccct atttcataga ggctggccct attagtgatt tccaaaaaca     2820

atatggaagt gccttttgat gtcttacaat aagagaagaa gccaatggaa atgaaagaga     2880

ttggcaaagg ggaaggatga tgccatgtag atcctgtttg acatttttat ggctgtattt     2940

gtaaacttaa acacaccagt gtctgttctt gatgcagttg ctatttagga tgagttaagt     3000

gcctggggag tccctcaaaa ggttaaaggg attcccatca ttggaatctt atcaccagat     3060

aggcaagttt atgaccaaac aagagagtac tggctttatc ctctaacctc atattttctc     3120

ccacttggca agtcctttgt ggcatttatt catcagtcag ggtgtccgat tggtcctaga     3180

acttccaaag gctgcttgtc atagaagcca ttgcatctat aaagcaacgg ctcctgttaa     3240

atggtatctc ctttctgagg ctcctactaa aagtcatttg ttacctaaac ttatgtgctt     3300

aacaggcaat gcttctcaga ccacaaagca gaaagaagaa gaaaagctcc tgactaaatc     3360

agggctgggc ttagacagag ttgatctgta gaatatcttt aaaggagaga tgtcaacttt     3420

ctgcactatt cccagcctct gctcctccct gtctaccctc tcccctccct ctctccctcc     3480

acttcacccc acaatcttga aaaacttcct ttctcttctg tgaacatcat tggccagatc     3540

cattttcagt ggtctggatt tctttttatt ttcttttcaa cttgaaagaa actggacatt     3600

aggccactat gtgttgttac tgccactagt gttcaagtgc ctcttgtttt cccagagatt     3660

tcctgggtct gccagaggcc cagacaggct cactcaagct ctttaactga aaagcaacaa     3720

gccactccag gacaaggttc aaaatggtta caacagcctc tacctgtcgc cccagggaga     3780

aaggggtagt gatacaagtc tcatagccag agatggtttt ccactccttc tagatattcc     3840

caaaaagagg ctgagacagg aggttatttt caattttatt ttggaattaa atactttttt     3900

ccctttatta ctgttgtagt ccctcacttg gatatacctc tgttttcacg atagaaataa     3960

gggaggtcta gagcttctat tccttggcca ttgtcaacgg agagctggcc aagtcttcac     4020

aaacccttgc aacattgcct gaagtttatg gaataagatg tattctcact cccttgatct     4080

caagggcgta actctggaag cacagcttga ctacacgtca tttttaccaa tgattttcag     4140

gtgacctggg ctaagtcatt taaactgggt ctttataaaa gtaaaaggcc aacatttaat     4200

tattttgcaa agcaacctaa gagctaaaga tgtaattttt cttgcaattg taaatctttt     4260

gtgtctcctg aagacttccc ttaaaattag ctctgagtga aaaatcaaaa gagacaaaag     4320

acatcttcga atccatattt caagcctggt agaattggct tttctagcag aacctttcca     4380

aaagttttat attgagattc ataacaacac caagaattga ttttgtagcc aacattcatt     4440

caatactgtt atatcagagg agtaggagag aggaaacatt tgacttatct ggaaaagcaa     4500

aatgtactta agaataagaa taacatggtc cattcacctt tatgttatag atatgtcttt     4560

gtgtaaatca tttgttttga gttttcaaag aatagcccat tgttcattct tgtgctgtac     4620

aatgaccact gttattgtta ctttgacttt tcagagcaca cccttcctct ggtttttgta     4680

tatttattga tggatcaata ataatgagga aagcatgata tgtatattgc tgagttgaaa     4740

gcacttattg gaaaatatta aaaggctaac attaaaagac taaaggaaac agaaaaaaaa     4800

aaaaaaaaa                                                             4809


<210>  17
<211>  4542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcaggta tgggttcata gaagggcacg tggtgattcc ccggatccac cccaactcca      720

tctgtgcagc aaacaacaca ggggtgtaca tcctcacatc caacacctcc cagtatgaca      780

catattgctt caatgcttca gctccacctg aagaagattg tacatcagtc acagacctgc      840

ccaatgcctt tgatggacca attaccataa ctattgttaa ccgtgatggc acccgctatg      900

tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg      960

atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt     1020

acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca     1080

cagacagaat ccctgctacc agacactcac atgggagtca agaaggtgga gcaaacacaa     1140

cctctggtcc tataaggaca ccccaaattc cagaatggct gatcatcttg gcatccctct     1200

tggccttggc tttgattctt gcagtttgca ttgcagtcaa cagtcgaaga aggtgtgggc     1260

agaagaaaaa gctagtgatc aacagtggca atggagctgt ggaggacaga aagccaagtg     1320

gactcaacgg agaggccagc aagtctcagg aaatggtgca tttggtgaac aaggagtcgt     1380

cagaaactcc agaccagttt atgacagctg atgagacaag gaacctgcag aatgtggaca     1440

tgaagattgg ggtgtaacac ctacaccatt atcttggaaa gaaacaaccg ttggaaacat     1500

aaccattaca gggagctggg acacttaaca gatgcaatgt gctactgatt gtttcattgc     1560

gaatcttttt tagcataaaa ttttctactc tttttgtttt ttgtgttttg ttctttaaag     1620

tcaggtccaa tttgtaaaaa cagcattgct ttctgaaatt agggcccaat taataatcag     1680

caagaatttg atcgttccag ttcccacttg gaggcctttc atccctcggg tgtgctatgg     1740

atggcttcta acaaaaacta cacatatgta ttcctgatcg ccaacctttc ccccaccagc     1800

taaggacatt tcccagggtt aatagggcct ggtccctggg aggaaatttg aatgggtcca     1860

ttttgccctt ccatagccta atccctgggc attgctttcc actgaggttg ggggttgggg     1920

tgtactagtt acacatcttc aacagacccc ctctagaaat ttttcagatg cttctgggag     1980

acacccaaag ggtgaagcta tttatctgta gtaaactatt tatctgtgtt tttgaaatat     2040

taaaccctgg atcagtcctt tgatcagtat aattttttaa agttactttg tcagaggcac     2100

aaaagggttt aaactgattc ataataaata tctgtacttc ttcgatcttc accttttgtg     2160

ctgtgattct tcagtttcta aaccagcact gtctgggtcc ctacaatgta tcaggaagag     2220

ctgagaatgg taaggagact cttctaagtc ttcatctcag agaccctgag ttcccactca     2280

gacccactca gccaaatctc atggaagacc aaggagggca gcactgtttt tgttttttgt     2340

tttttgtttt ttttttttga cactgtccaa aggttttcca tcctgtcctg gaatcagagt     2400

tggaagctga ggagcttcag cctcttttat ggtttaatgg ccacctgttc tctcctgtga     2460

aaggctttgc aaagtcacat taagtttgca tgacctgtta tccctggggc cctatttcat     2520

agaggctggc cctattagtg atttccaaaa acaatatgga agtgcctttt gatgtcttac     2580

aataagagaa gaagccaatg gaaatgaaag agattggcaa aggggaagga tgatgccatg     2640

tagatcctgt ttgacatttt tatggctgta tttgtaaact taaacacacc agtgtctgtt     2700

cttgatgcag ttgctattta ggatgagtta agtgcctggg gagtccctca aaaggttaaa     2760

gggattccca tcattggaat cttatcacca gataggcaag tttatgacca aacaagagag     2820

tactggcttt atcctctaac ctcatatttt ctcccacttg gcaagtcctt tgtggcattt     2880

attcatcagt cagggtgtcc gattggtcct agaacttcca aaggctgctt gtcatagaag     2940

ccattgcatc tataaagcaa cggctcctgt taaatggtat ctcctttctg aggctcctac     3000

taaaagtcat ttgttaccta aacttatgtg cttaacaggc aatgcttctc agaccacaaa     3060

gcagaaagaa gaagaaaagc tcctgactaa atcagggctg ggcttagaca gagttgatct     3120

gtagaatatc tttaaaggag agatgtcaac tttctgcact attcccagcc tctgctcctc     3180

cctgtctacc ctctcccctc cctctctccc tccacttcac cccacaatct tgaaaaactt     3240

cctttctctt ctgtgaacat cattggccag atccattttc agtggtctgg atttcttttt     3300

attttctttt caacttgaaa gaaactggac attaggccac tatgtgttgt tactgccact     3360

agtgttcaag tgcctcttgt tttcccagag atttcctggg tctgccagag gcccagacag     3420

gctcactcaa gctctttaac tgaaaagcaa caagccactc caggacaagg ttcaaaatgg     3480

ttacaacagc ctctacctgt cgccccaggg agaaaggggt agtgatacaa gtctcatagc     3540

cagagatggt tttccactcc ttctagatat tcccaaaaag aggctgagac aggaggttat     3600

tttcaatttt attttggaat taaatacttt tttcccttta ttactgttgt agtccctcac     3660

ttggatatac ctctgttttc acgatagaaa taagggaggt ctagagcttc tattccttgg     3720

ccattgtcaa cggagagctg gccaagtctt cacaaaccct tgcaacattg cctgaagttt     3780

atggaataag atgtattctc actcccttga tctcaagggc gtaactctgg aagcacagct     3840

tgactacacg tcatttttac caatgatttt caggtgacct gggctaagtc atttaaactg     3900

ggtctttata aaagtaaaag gccaacattt aattattttg caaagcaacc taagagctaa     3960

agatgtaatt tttcttgcaa ttgtaaatct tttgtgtctc ctgaagactt cccttaaaat     4020

tagctctgag tgaaaaatca aaagagacaa aagacatctt cgaatccata tttcaagcct     4080

ggtagaattg gcttttctag cagaaccttt ccaaaagttt tatattgaga ttcataacaa     4140

caccaagaat tgattttgta gccaacattc attcaatact gttatatcag aggagtagga     4200

gagaggaaac atttgactta tctggaaaag caaaatgtac ttaagaataa gaataacatg     4260

gtccattcac ctttatgtta tagatatgtc tttgtgtaaa tcatttgttt tgagttttca     4320

aagaatagcc cattgttcat tcttgtgctg tacaatgacc actgttattg ttactttgac     4380

ttttcagagc acacccttcc tctggttttt gtatatttat tgatggatca ataataatga     4440

ggaaagcatg atatgtatat tgctgagttg aaagcactta ttggaaaata ttaaaaggct     4500

aacattaaaa gactaaagga aacagaaaaa aaaaaaaaaa aa                        4542


<210>  18
<211>  2261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
gagaagaaag ccagtgcgtc tctgggcgca ggggccagtg gggctcggag gcacaggcac       60

cccgcgacac tccaggttcc ccgacccacg tccctggcag ccccgattat ttacagcctc      120

agcagagcac ggggcggggg cagaggggcc cgcccgggag ggctgctact tcttaaaacc      180

tctgcgggct gcttagtcac agcccccctt gcttgggtgt gtccttcgct cgctccctcc      240

ctccgtctta ggtcactgtt ttcaacctcg aataaaaact gcagccaact tccgaggcag      300

cctcattgcc cagcggaccc cagcctctgc caggttcggt ccgccatcct cgtcccgtcc      360

tccgccggcc cctgccccgc gcccagggat cctccagctc ctttcgcccg cgccctccgt      420

tcgctccgga caccatggac aagttttggt ggcacgcagc ctggggactc tgcctcgtgc      480

cgctgagcct ggcgcagatc gatttgaata taacctgccg ctttgcaggt gtattccacg      540

tggagaaaaa tggtcgctac agcatctctc ggacggaggc cgctgacctc tgcaaggctt      600

tcaatagcac cttgcccaca atggcccaga tggagaaagc tctgagcatc ggatttgaga      660

cctgcaggta tgggttcata gaagggcacg tggtgattcc ccggatccac cccaactcca      720

tctgtgcagc aaacaacaca ggggtgtaca tcctcacatc caacacctcc cagtatgaca      780

catattgctt caatgcttca gctccacctg aagaagattg tacatcagtc acagacctgc      840

ccaatgcctt tgatggacca attaccataa ctattgttaa ccgtgatggc acccgctatg      900

tccagaaagg agaatacaga acgaatcctg aagacatcta ccccagcaac cctactgatg      960

atgacgtgag cagcggctcc tccagtgaaa ggagcagcac ttcaggaggt tacatctttt     1020

acaccttttc tactgtacac cccatcccag acgaagacag tccctggatc accgacagca     1080

cagacagaat ccctgctacc agagaccaag acacattcca ccccagtggg gggtcccata     1140

ccactcatgg atctgaatca gatggacact cacatgggag tcaagaaggt ggagcaaaca     1200

caacctctgg tcctataagg acaccccaaa ttccagaatg gctgatcatc ttggcatccc     1260

tcttggcctt ggctttgatt cttgcagttt gcattgcagt caacagtcga agaagttgaa     1320

gagattcagg ttatagcata agaagagcac tgtttcatcg tcttcttgct gttaggaggt     1380

ctatgaagca gagaagaact ttcctttgga aaacaactaa atgaagacag tcacctcgct     1440

agaactgaca catgggctgt ttttatattc ttgaaggcca ctctctccct acctgaacca     1500

agacctatag gtttacatgt tatttacatt ttatatataa tatatatata tatatataca     1560

catacattat atatacacaa tagtaattct agcaacagag gaaatgacct ttaacagggg     1620

tataaatcta aatttataaa agtataaatc taaatttctt acccaagaca ctttaaagat     1680

acattatttt tctccaggac gtaattcata ggaatattaa gccttttgta aatgtccctt     1740

tagatggttt ctcataaggt aaaagaaact tatttccaag caggaccacc tttattgtgt     1800

ccccagatca cctcacaggg cagaaaaatg cccctcagtc tgggagaaga cctagagaga     1860

attatggact ccttactggt ttttggaaag caaccaacag ctaattccaa caccatgggc     1920

agcccataca gtctctaatt atctgagaaa atcaaatgat gctgttacaa taattacgct     1980

ggtacaagtt aataaaagtg ccatgttaca gtcaaacagc tatgttgcta tctataccat     2040

tgagggcata gttttaaaaa gtagttatgc tacctgattg tataaggaac aaaactgaga     2100

gaaaaaatct aaaaggccgc ctatgattga atggaaagat tttttttagt tgaatttaaa     2160

taatgtgact tgggggagcc tttacaaaga gtctttatac ctcccttcag cttcctcatt     2220

ttcccttgga ttacttttgc tcaattaaat atgaatttcc t                         2261


<210>  19
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19

Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr 
65                  70                  75                  80  


Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
            100                 105                 110         


Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             


Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    130                 135                 140                 


Met Met Thr Ala Lys 
145                 


<210>  20
<211>  2277
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20
ggcggggcgc gcgcggcggc cgttgaggga ccgttggggc gggaggcggc ggcggcggcg       60

gcgcgcgctg cgggcagtga gtgtggaggc gcggacgcgc ggcggagctg gaactgctgc      120

agctgctgcc gccgccggag gaaccttgat ccccgtgctc cggacacccc gggcctcgcc      180

atggctgacc agctgactga ggagcagatt gcagagttca aggaggcctt ctccctcttt      240

gacaaggatg gagatggcac tatcaccacc aaggagttgg ggacagtgat gagatccctg      300

ggacagaacc ccactgaagc agagctgcag gatatgatca atgaggtgga tgcagatggg      360

aacgggacca ttgacttccc ggagttcctg accatgatgg ccagaaagat gaaggacaca      420

gacagtgagg aggagatccg agaggcgttc cgtgtctttg acaaggatgg gaatggctac      480

atcagcgccg cagagctgcg tcacgtaatg acgaacctgg gggagaagct gaccgatgag      540

gaggtggatg agatgatcag ggaggctgac atcgatggag atggccaggt caattatgaa      600

gagtttgtac agatgatgac tgcaaagtga aggccccccg ggcagctggc gatgcccgtt      660

ctcttgatct ctctcttctc gcgcgcgcac tctctcttca acactcccct gcgtaccccg      720

gttctagcaa acaccaattg attgactgag aatctgataa agcaacaaaa gatttgtccc      780

aagctgcatg attgctcttt ctccttcttc cctgagtctc tctccatgcc cctcatctct      840

tccttttgcc ctcgcctctt ccatccatgt cttccaaggc ctgatgcatt cataagttga      900

agccctcccc agatcccctt ggggagcctc tgccctcctc cagcccggat ggctctcctc      960

cattttggtt tgtttcctct tgtttgtcat cttattttgg gtgctggggt ggctgccagc     1020

cctgtcccgg gacctgctgg gagggacaag aggccctccc ccaggcagaa gagcatgccc     1080

tttgccgttg catgcaacca gccctgtgat tccacgtgca gatcccagca gcctgttggg     1140

gcaggggtgc caagagaggc attccagaag gactgagggg gcgttgagga attgtggcgt     1200

tgactggatg tggcccagga gggggtcgag ggggccaact cacagaaggg gactgacagt     1260

gggcaacact cacatcccac tggctgctgt tctgaaacca tctgattggc tttctgaggt     1320

ttggctgggt ggggactgct catttggcca ctctgcaaat tggacttgcc cgcgttcctg     1380

aagcgctctc gagctgttct gtaaatacct ggtgctaaca tcccatgccg ctccctcctc     1440

acgatgcacc caccgccctg agggcccgtc ctaggaatgg atgtggggat ggtcgctttg     1500

taatgtgctg gttctctttt tttttctttc ccctctatgg cccttaagac tttcattttg     1560

ttcagaacca tgctgggcta gctaaagggt ggggagaggg aagatgggcc ccaccacgct     1620

ctcaagagaa cgcacctgca ataaaacagt cttgtcggcc agctgcccag gggacggcag     1680

ctacagcagc ctctgcgtcc tggtccgcca gcacctcccg cttctccgtg gtgacttggc     1740

gccgcttcct cacatctgtg ctccgtgccc tcttccctgc ctcttccctc gcccacctgc     1800

ctgcccccat actcccccag cggagagcat gatccgtgcc cttgcttctg actttcgcct     1860

ctgggacaag taagtcaatg tgggcagttc agtcgtctgg gttttttccc cttttctgtt     1920

catttcatct ggctcccccc accacctccc caccccaccc cccaccccct gcttcccctc     1980

actgcccagg tcgatcaagt ggcttttcct gggacctgcc cagctttgag aatctcttct     2040

catccaccct ctggcaccca gcctctgagg gaaggaggga tggggcatag tgggagaccc     2100

agccaagagc tgagggtaag ggcaggtagg cgtgaggctg tggacatttt cggaatgttt     2160

tggttttgtt ttttttaaac cgggcaatat tgtgttcagt tcaagctgtg aagaaaaata     2220

tatatcaatg ttttccaata aaatacagtg actacctgaa aaaaaaaaaa aaaaaaa        2277


<210>  21
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  22
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  23
<211>  1690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23
tgctttctca aaggccccac agtcctccac ttcctgggga ggtagctgca gaataaaacc       60

agcagagact ccttttctcc taaccgtccc ggccaccgct gcctcagcct ctgcctccca      120

gcctctttct gagggaaagg acaagatgaa gtggaaggcg cttttcaccg cggccatcct      180

gcaggcacag ttgccgatta cagaggcaca gagctttggc ctgctggatc ccaaactctg      240

ctacctgctg gatggaatcc tcttcatcta tggtgtcatt ctcactgcct tgttcctgag      300

agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta      360

taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg      420

ggaccctgag atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa      480

tgaactgcag aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg      540

ccggaggggc aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac      600

ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa cagccagggg atttcaccac      660

tcaaaggcca gacctgcaga cgcccagatt atgagacaca ggatgaagca tttacaaccc      720

ggttcactct tctcagccac tgaagtattc ccctttatgt acaggatgct ttggttatat      780

ttagctccaa accttcacac acagactgtt gtccctgcac tctttaaggg agtgtactcc      840

cagggcttac ggccctggcc ttgggccctc tggtttgccg gtggtgcagg tagacctgtc      900

tcctggcggt tcctcgttct ccctgggagg cgggcgcact gcctctcaca gctgagttgt      960

tgagtctgtt ttgtaaagtc cccagagaaa gcgcagatgc tagcacatgc cctaatgtct     1020

gtatcactct gtgtctgagt ggcttcactc ctgctgtaaa tttggcttct gttgtcacct     1080

tcacctcctt tcaaggtaac tgtactgggc catgttgtgc ctccctggtg agagggccgg     1140

gcagaggggc agatggaaag gagcctaggc caggtgcaac cagggagctg caggggcatg     1200

ggaaggtggg cgggcagggg agggtcagcc agggcctgcg agggcagcgg gagcctccct     1260

gcctcaggcc tctgtgccgc accattgaac tgtaccatgt gctacagggg ccagaagatg     1320

aacagactga ccttgatgag ctgtgcacaa agtggcataa aaaacatgtg gttacacagt     1380

gtgaataaag tgctgcggag caagaggagg ccgttgattc acttcacgct ttcagcgaat     1440

gacaaaatca tctttgtgaa ggcctcgcag gaagacccaa cacatgggac ctataactgc     1500

ccagcggaca gtggcaggac aggaaaaacc cgtcaatgta ctaggatact gctgcgtcat     1560

tacagggcac aggccatgga tggaaaacgc tctctgctct gctttttttc tactgtttta     1620

atttatactg gcatgctaaa gccttcctat tttgcataat aaatgcttca gtgaaaatgc     1680

aaaaaaaaaa                                                            1690


<210>  24
<211>  1687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24
tgctttctca aaggccccac agtcctccac ttcctgggga ggtagctgca gaataaaacc       60

agcagagact ccttttctcc taaccgtccc ggccaccgct gcctcagcct ctgcctccca      120

gcctctttct gagggaaagg acaagatgaa gtggaaggcg cttttcaccg cggccatcct      180

gcaggcacag ttgccgatta cagaggcaca gagctttggc ctgctggatc ccaaactctg      240

ctacctgctg gatggaatcc tcttcatcta tggtgtcatt ctcactgcct tgttcctgag      300

agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta      360

taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg      420

ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga      480

actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg      540

gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta      600

cgacgccctt cacatgcagg ccctgccccc tcgctaacag ccaggggatt tcaccactca      660

aaggccagac ctgcagacgc ccagattatg agacacagga tgaagcattt acaacccggt      720

tcactcttct cagccactga agtattcccc tttatgtaca ggatgctttg gttatattta      780

gctccaaacc ttcacacaca gactgttgtc cctgcactct ttaagggagt gtactcccag      840

ggcttacggc cctggccttg ggccctctgg tttgccggtg gtgcaggtag acctgtctcc      900

tggcggttcc tcgttctccc tgggaggcgg gcgcactgcc tctcacagct gagttgttga      960

gtctgttttg taaagtcccc agagaaagcg cagatgctag cacatgccct aatgtctgta     1020

tcactctgtg tctgagtggc ttcactcctg ctgtaaattt ggcttctgtt gtcaccttca     1080

cctcctttca aggtaactgt actgggccat gttgtgcctc cctggtgaga gggccgggca     1140

gaggggcaga tggaaaggag cctaggccag gtgcaaccag ggagctgcag gggcatggga     1200

aggtgggcgg gcaggggagg gtcagccagg gcctgcgagg gcagcgggag cctccctgcc     1260

tcaggcctct gtgccgcacc attgaactgt accatgtgct acaggggcca gaagatgaac     1320

agactgacct tgatgagctg tgcacaaagt ggcataaaaa acatgtggtt acacagtgtg     1380

aataaagtgc tgcggagcaa gaggaggccg ttgattcact tcacgctttc agcgaatgac     1440

aaaatcatct ttgtgaaggc ctcgcaggaa gacccaacac atgggaccta taactgccca     1500

gcggacagtg gcaggacagg aaaaacccgt caatgtacta ggatactgct gcgtcattac     1560

agggcacagg ccatggatgg aaaacgctct ctgctctgct ttttttctac tgttttaatt     1620

tatactggca tgctaaagcc ttcctatttt gcataataaa tgcttcagtg aaaatgcaaa     1680

aaaaaaa                                                               1687


<210>  25
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25

Met Ala Gln Thr Gln Gly Thr Arg Arg Lys Val Cys Tyr Tyr Tyr Asp 
1               5                   10                  15      


Gly Asp Val Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys Pro 
            20                  25                  30          


His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu Tyr 
        35                  40                  45              


Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Asn Ala Glu Glu Met 
    50                  55                  60                  


Thr Lys Tyr His Ser Asp Asp Tyr Ile Lys Phe Leu Arg Ser Ile Arg 
65                  70                  75                  80  


Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn Val 
                85                  90                  95      


Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln Leu 
            100                 105                 110         


Ser Thr Gly Gly Ser Val Ala Ser Ala Val Lys Leu Asn Lys Gln Gln 
        115                 120                 125             


Thr Asp Ile Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys Lys 
    130                 135                 140                 


Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala Ile 
145                 150                 155                 160 


Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile Asp 
                165                 170                 175     


Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp Arg 
            180                 185                 190         


Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly Thr 
        195                 200                 205             


Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala Val 
    210                 215                 220                 


Asn Tyr Pro Leu Arg Asp Gly Ile Asp Asp Glu Ser Tyr Glu Ala Ile 
225                 230                 235                 240 


Phe Lys Pro Val Met Ser Lys Val Met Glu Met Phe Gln Pro Ser Ala 
                245                 250                 255     


Val Val Leu Gln Cys Gly Ser Asp Ser Leu Ser Gly Asp Arg Leu Gly 
            260                 265                 270         


Cys Phe Asn Leu Thr Ile Lys Gly His Ala Lys Cys Val Glu Phe Val 
        275                 280                 285             


Lys Ser Phe Asn Leu Pro Met Leu Met Leu Gly Gly Gly Gly Tyr Thr 
    290                 295                 300                 


Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala Leu 
305                 310                 315                 320 


Asp Thr Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu Tyr 
                325                 330                 335     


Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr Asn 
            340                 345                 350         


Gln Asn Thr Asn Glu Tyr Leu Glu Lys Ile Lys Gln Arg Leu Phe Glu 
        355                 360                 365             


Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala Ile 
    370                 375                 380                 


Pro Glu Asp Ala Ile Pro Glu Glu Ser Gly Asp Glu Asp Glu Asp Asp 
385                 390                 395                 400 


Pro Asp Lys Arg Ile Ser Ile Cys Ser Ser Asp Lys Arg Ile Ala Cys 
                405                 410                 415     


Glu Glu Glu Phe Ser Asp Ser Glu Glu Glu Gly Glu Gly Gly Arg Lys 
            420                 425                 430         


Asn Ser Ser Asn Phe Lys Lys Ala Lys Arg Val Lys Thr Glu Asp Glu 
        435                 440                 445             


Lys Glu Lys Asp Pro Glu Glu Lys Lys Glu Val Thr Glu Glu Glu Lys 
    450                 455                 460                 


Thr Lys Glu Glu Lys Pro Glu Ala Lys Gly Val Lys Glu Glu Val Lys 
465                 470                 475                 480 


Leu Ala 
        


<210>  26
<211>  2091
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26
gagcggagcc gcgggcggga gggcggacgg accgactgac ggtagggacg ggaggcgagc       60

aagatggcgc agacgcaggg cacccggagg aaagtctgtt actactacga cggggatgtt      120

ggaaattact attatggaca aggccaccca atgaagcctc accgaatccg catgactcat      180

aatttgctgc tcaactatgg tctctaccga aaaatggaaa tctatcgccc tcacaaagcc      240

aatgctgagg agatgaccaa gtaccacagc gatgactaca ttaaattctt gcgctccatc      300

cgtccagata acatgtcgga gtacagcaag cagatgcaga gattcaacgt tggtgaggac      360

tgtccagtat tcgatggcct gtttgagttc tgtcagttgt ctactggtgg ttctgtggca      420

agtgctgtga aacttaataa gcagcagacg gacatcgctg tgaattgggc tgggggcctg      480

caccatgcaa agaagtccga ggcatctggc ttctgttacg tcaatgatat cgtcttggcc      540

atcctggaac tgctaaagta tcaccagagg gtgctgtaca ttgacattga tattcaccat      600

ggtgacggcg tggaagaggc cttctacacc acggaccggg tcatgactgt gtcctttcat      660

aagtatggag agtacttccc aggaactggg gacctacggg atatcggggc tggcaaaggc      720

aagtattatg ctgttaacta cccgctccga gacgggattg atgacgagtc ctatgaggcc      780

attttcaagc cggtcatgtc caaagtaatg gagatgttcc agcctagtgc ggtggtctta      840

cagtgtggct cagactccct atctggggat cggttaggtt gcttcaatct aactatcaaa      900

ggacacgcca agtgtgtgga atttgtcaag agctttaacc tgcctatgct gatgctggga      960

ggcggtggtt acaccattcg taacgttgcc cggtgctgga catatgagac agctgtggcc     1020

ctggatacgg agatccctaa tgagcttcca tacaatgact actttgaata ctttggacca     1080

gatttcaagc tccacatcag tccttccaat atgactaacc agaacacgaa tgagtacctg     1140

gagaagatca aacagcgact gtttgagaac cttagaatgc tgccgcacgc acctggggtc     1200

caaatgcagg cgattcctga ggacgccatc cctgaggaga gtggcgatga ggacgaagac     1260

gaccctgaca agcgcatctc gatctgctcc tctgacaaac gaattgcctg tgaggaagag     1320

ttctccgatt ctgaagagga gggagagggg ggccgcaaga actcttccaa cttcaaaaaa     1380

gccaagagag tcaaaacaga ggatgaaaaa gagaaagacc cagaggagaa gaaagaagtc     1440

accgaagagg agaaaaccaa ggaggagaag ccagaagcca aaggggtcaa ggaggaggtc     1500

aagttggcct gaatggacct ctccagctct ggcttcctgc tgagtccctc acgtttcttc     1560

cccaacccct cagattttat attttctatt tctctgtgta tttatataaa aatttattaa     1620

atataaatat ccccagggac agaaaccaag gccccgagct cagggcagct gtgctgggtg     1680

agctcttcca ggagccacct tgccacccat tcttcccgtt cttaactttg aaccataaag     1740

ggtgccaggt ctgggtgaaa gggatacttt tatgcaacca taagacaaac tcctgaaatg     1800

ccaagtgcct gcttagtagc tttggaaagg tgcccttatt gaacattcta gaaggggtgg     1860

ctgggtcttc aaggatctcc tgtttttttc aggctcctaa agtaacatca gccattttta     1920

gattggttct gttttcgtac cttcccactg gcctcaagtg agccaagaaa cactgcctgc     1980

cctctgtctg tcttctccta attctgcagg tggaggttgc tagtctagtt tcctttttga     2040

gatactattt tcatttttgt gagcctcttt gtaataaaat ggtacatttc t              2091


<210>  27
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27

Met Ala Leu Pro Phe Val Leu Leu Met Ala Leu Val Val Leu Asn Cys 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Ser Asn Arg Arg Thr Leu Met Ile Met Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Met Met Gln Glu Val Gly 
        115                 120                 125             


Val Glu Asp Thr Pro Leu Met Asn Val Asp Ser Ile Leu Thr Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ala Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  28
<211>  700
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28
gcccaaggtt cagggtcact caatctcaac agcccagaag catctgcaac ctccccaatg       60

gccttgccct ttgttttact gatggccctg gtggtgctca actgcaagtc aatctgttct      120

ctgggctgtg atctgcctca gacccacagc ctgagtaaca ggaggacttt gatgataatg      180

gcacaaatgg gaagaatctc tcctttctcc tgcctgaagg acagacatga ctttggattt      240

cctcaggagg agtttgatgg caaccagttc cagaaggctc aagccatctc tgtcctccat      300

gagatgatcc agcagacctt caatctcttc agcacaaagg actcatctgc tacttgggat      360

gagacacttc tagacaaatt ctacactgaa ctttaccagc agctgaatga cctggaagcc      420

tgtatgatgc aggaggttgg agtggaagac actcctctga tgaatgtgga ctctatcctg      480

actgtgagaa aatactttca aagaatcacc ctctatctga cagagaagaa atacagccct      540

tgtgcatggg aggttgtcag agcagaaatc atgagatcct tctctttatc agcaaacttg      600

caagaaagat taaggaggaa ggaatgaaaa ctggttcaac atcgaaatga ttctcattga      660

ctagtacacc atttcacact tcttgagttc tgccgtttca                            700


<210>  29
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29

Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg 
1               5                   10                  15      


Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser 
            20                  25                  30          


Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Asp 
        35                  40                  45              


Phe Cys Thr Asp Leu Ala Val Ser Ser Ala Asn Phe Ile Pro Thr Val 
    50                  55                  60                  


Thr Ala Ile Ser Thr Ser Pro Asp Leu Gln Trp Leu Val Gln Pro Ala 
65                  70                  75                  80  


Leu Val Ser Ser Val Ala Pro Ser Gln Thr Arg Ala Pro His Pro Phe 
                85                  90                  95      


Gly Val Pro Ala Pro Ser Ala Gly Ala Tyr Ser Arg Ala Gly Val Val 
            100                 105                 110         


Lys Thr Met Thr Gly Gly Arg Ala Gln Ser Ile Gly Arg Arg Gly Lys 
        115                 120                 125             


Val Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg Ile Arg Arg 
    130                 135                 140                 


Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg Glu 
145                 150                 155                 160 


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
                165                 170                 175     


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            180                 185                 190         


Leu Glu Phe Ile Leu Ala Ala His Arg Pro Ala Cys Lys Ile Pro Asp 
        195                 200                 205             


Asp Leu Gly Phe Pro Glu Glu Met Ser Val Ala Ser Leu Asp Leu Thr 
    210                 215                 220                 


Gly Gly Leu Pro Glu Val Ala Thr Pro Glu Ser Glu Glu Ala Phe Thr 
225                 230                 235                 240 


Leu Pro Leu Leu Asn Asp Pro Glu Pro Lys Pro Ser Val Glu Pro Val 
                245                 250                 255     


Lys Ser Ile Ser Ser Met Glu Leu Lys Thr Glu Pro Phe Asp Asp Phe 
            260                 265                 270         


Leu Phe Pro Ala Ser Ser Arg Pro Ser Gly Ser Glu Thr Ala Arg Ser 
        275                 280                 285             


Val Pro Asp Met Asp Leu Ser Gly Ser Phe Tyr Ala Ala Asp Trp Glu 
    290                 295                 300                 


Pro Leu His Ser Gly Ser Leu Gly Met Gly Pro Met Ala Thr Glu Leu 
305                 310                 315                 320 


Glu Pro Leu Cys Thr Pro Val Val Thr Cys Thr Pro Ser Cys Thr Ala 
                325                 330                 335     


Tyr Thr Ser Ser Phe Val Phe Thr Tyr Pro Glu Ala Asp Ser Phe Pro 
            340                 345                 350         


Ser Cys Ala Ala Ala His Arg Lys Gly Ser Ser Ser Asn Glu Pro Ser 
        355                 360                 365             


Ser Asp Ser Leu Ser Ser Pro Thr Leu Leu Ala Leu 
    370                 375                 380 


<210>  30
<211>  2158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30
attcataaaa cgcttgttat aaaagcagtg gctgcggcgc ctcgtactcc aaccgcatct       60

gcagcgagca tctgagaagc caagactgag ccggcggccg cggcgcagcg aacgagcagt      120

gaccgtgctc ctacccagct ctgctccaca gcgcccacct gtctccgccc ctcggcccct      180

cgcccggctt tgcctaaccg ccacgatgat gttctcgggc ttcaacgcag actacgaggc      240

gtcatcctcc cgctgcagca gcgcgtcccc ggccggggat agcctctctt actaccactc      300

acccgcagac tccttctcca gcatgggctc gcctgtcaac gcgcaggact tctgcacgga      360

cctggccgtc tccagtgcca acttcattcc cacggtcact gccatctcga ccagtccgga      420

cctgcagtgg ctggtgcagc ccgccctcgt ctcctccgtg gccccatcgc agaccagagc      480

ccctcaccct ttcggagtcc ccgccccctc cgctggggct tactccaggg ctggcgttgt      540

gaagaccatg acaggaggcc gagcgcagag cattggcagg aggggcaagg tggaacagtt      600

atctccagaa gaagaagaga aaaggagaat ccgaagggaa aggaataaga tggctgcagc      660

caaatgccgc aaccggagga gggagctgac tgatacactc caagcggaga cagaccaact      720

agaagatgag aagtctgctt tgcagaccga gattgccaac ctgctgaagg agaaggaaaa      780

actagagttc atcctggcag ctcaccgacc tgcctgcaag atccctgatg acctgggctt      840

cccagaagag atgtctgtgg cttcccttga tctgactggg ggcctgccag aggttgccac      900

cccggagtct gaggaggcct tcaccctgcc tctcctcaat gaccctgagc ccaagccctc      960

agtggaacct gtcaagagca tcagcagcat ggagctgaag accgagccct ttgatgactt     1020

cctgttccca gcatcatcca ggcccagtgg ctctgagaca gcccgctccg tgccagacat     1080

ggacctatct gggtccttct atgcagcaga ctgggagcct ctgcacagtg gctccctggg     1140

gatggggccc atggccacag agctggagcc cctgtgcact ccggtggtca cctgtactcc     1200

cagctgcact gcttacacgt cttccttcgt cttcacctac cccgaggctg actccttccc     1260

cagctgtgca gctgcccacc gcaagggcag cagcagcaat gagccttcct ctgactcgct     1320

cagctcaccc acgctgctgg ccctgtgagg gggcagggaa ggggaggcag ccggcaccca     1380

caagtgccac tgcccgagct ggtgcattac agagaggaga aacacatctt ccctagaggg     1440

ttcctgtaga cctagggagg accttatctg tgcgtgaaac acaccaggct gtgggcctca     1500

aggacttgaa agcatccatg tgtggactca agtccttacc tcttccggag atgtagcaaa     1560

acgcatggag tgtgtattgt tcccagtgac acttcagaga gctggtagtt agtagcatgt     1620

tgagccaggc ctgggtctgt gtctcttttc tctttctcct tagtcttctc atagcattaa     1680

ctaatctatt gggttcatta ttggaattaa cctggtgctg gatattttca aattgtatct     1740

agtgcagctg attttaacaa taactactgt gttcctggca atagtgtgtt ctgattagaa     1800

atgaccaata ttatactaag aaaagatacg actttatttt ctggtagata gaaataaata     1860

gctatatcca tgtactgtag tttttcttca acatcaatgt tcattgtaat gttactgatc     1920

atgcattgtt gaggtggtct gaatgttctg acattaacag ttttccatga aaacgtttta     1980

ttgtgttttt aatttattta ttaagatgga ttctcagata tttatatttt tattttattt     2040

ttttctacct tgaggtcttt tgacatgtgg aaagtgaatt tgaatgaaaa atttaagcat     2100

tgtttgctta ttgttccaag acattgtcaa taaaagcatt taagttgaat gcgaccaa       2158


