                         SEQUENCE LISTING

<110>  FORD, Byron D
 
<120>  BIOMARKERS FOR STROKE

<130>  1013-108

<140>  13/204,358
<141>  2011-08-05

<150>  61/344,517
<151>  2010-08-13

<160>  139   

<170>  PatentIn version 3.5

<210>  1
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Leu Tyr Ser Leu Ser Val Leu Tyr Lys Gly Glu Ala Lys Val 
1               5                   10                  15      


Val Leu Leu Lys Ala Ala Tyr Asp Val Ser Ser Phe Ser Phe Phe Gln 
            20                  25                  30          


Arg Ser Ser Val Gln Glu Phe Met Thr Phe Thr Ser Gln Leu Ile Val 
        35                  40                  45              


Glu Arg Ser Ser Lys Gly Thr Arg Ala Ser Val Lys Glu Gln Asp Tyr 
    50                  55                  60                  


Leu Cys His Val Tyr Val Arg Asn Asp Ser Leu Ala Gly Val Val Ile 
65                  70                  75                  80  


Ala Asp Asn Glu Tyr Pro Ser Arg Val Ala Phe Thr Leu Leu Glu Lys 
                85                  90                  95      


Val Leu Asp Glu Phe Ser Lys Gln Val Asp Arg Ile Asp Trp Pro Val 
            100                 105                 110         


Gly Ser Pro Ala Thr Ile His Tyr Pro Ala Leu Asp Gly His Leu Ser 
        115                 120                 125             


Arg Tyr Gln Asn Pro Arg Glu Ala Asp Pro Met Thr Lys Val Gln Ala 
    130                 135                 140                 


Glu Leu Asp Glu Thr Lys Ile Ile Leu His Asn Thr Met Glu Ser Leu 
145                 150                 155                 160 


Leu Glu Arg Gly Glu Lys Leu Asp Asp Leu Val Ser Lys Ser Glu Val 
                165                 170                 175     


Leu Gly Thr Gln Ser Lys Ala Phe Tyr Lys Thr Ala Arg Lys Gln Asn 
            180                 185                 190         


Ser Cys Cys Ala Ile Met 
        195             


<210>  2
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gln Lys Arg Pro Ala Cys Thr Leu Lys Pro Glu Cys Val Gln 
1               5                   10                  15      


Gln Leu Leu Val Cys Ser Gln Glu Ala Lys Lys Ser Ala Tyr Cys Pro 
            20                  25                  30          


Tyr Ser His Phe Pro Val Gly Ala Ala Leu Leu Thr Gln Glu Gly Arg 
        35                  40                  45              


Ile Phe Lys Gly Cys Asn Ile Glu Asn Ala Cys Tyr Pro Leu Gly Ile 
    50                  55                  60                  


Cys Ala Glu Arg Thr Ala Ile Gln Lys Ala Val Ser Glu Gly Tyr Lys 
65                  70                  75                  80  


Asp Phe Arg Ala Ile Ala Ile Ala Ser Asp Met Gln Asp Asp Phe Ile 
                85                  90                  95      


Ser Pro Cys Gly Ala Cys Arg Gln Val Met Arg Glu Phe Gly Thr Asn 
            100                 105                 110         


Trp Pro Val Tyr Met Thr Lys Pro Asp Gly Thr Tyr Ile Val Met Thr 
        115                 120                 125             


Val Gln Glu Leu Leu Pro Ser Ser Phe Gly Pro Glu Asp Leu Gln Lys 
    130                 135                 140                 


Thr Gln 
145     


<210>  3
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gly Ala Gly Glu Arg Lys Gly Lys Lys Asp Asp Asn Gly Ile 
1               5                   10                  15      


Gly Thr Ala Ile Asp Phe Val Leu Ser Asn Ala Arg Leu Val Leu Gly 
            20                  25                  30          


Val Gly Gly Ala Ala Met Leu Gly Ile Ala Thr Leu Ala Val Lys Arg 
        35                  40                  45              


Met Tyr Asp Arg Ala Ile Ser Ala Pro Thr Ser Pro Thr Arg Leu Ser 
    50                  55                  60                  


His Ser Gly Lys Arg Ser Trp Glu Glu Pro Asn Trp Met Gly Ser Pro 
65                  70                  75                  80  


Arg Leu Leu Asn Arg Asp Met Lys Thr Gly Leu Ser Arg Ser Leu Gln 
                85                  90                  95      


Thr Leu Pro Thr Asp Ser Ser Thr Phe Asp Thr Asp Thr Phe Cys Pro 
            100                 105                 110         


Pro Arg Pro Lys Pro Val Ala Arg Lys Gly Gln Val Asp Leu Lys Lys 
        115                 120                 125             


Ser Arg Leu Arg Met Ser Leu Gln Glu Lys Leu Leu Thr Tyr Tyr Arg 
    130                 135                 140                 


Asn Arg Ala Ala Ile Pro Ala Gly Glu Gln Ala Arg Ala Lys Gln Ala 
145                 150                 155                 160 


Ala Val Asp Ile Cys Ala Glu Leu Arg Ser Phe Leu Arg Ala Lys Leu 
                165                 170                 175     


Pro Asp Met Pro Leu Arg Asp Met Tyr Leu Ser Gly Ser Leu Tyr Asp 
            180                 185                 190         


Asp Leu Gln Val Val Thr Ala Asp His Ile Gln Leu Ile Val Pro Leu 
        195                 200                 205             


Val Leu Glu Gln Asn Leu Trp Ser Cys Ile Pro Gly Glu Asp Thr Ile 
    210                 215                 220                 


Met Asn Val Pro Gly Phe Phe Leu Val Arg Arg Glu Asn Pro Glu Tyr 
225                 230                 235                 240 


Phe Pro Arg Gly Ser Ser Tyr Trp Asp Arg Cys Val Val Gly Gly Tyr 
                245                 250                 255     


Leu Ser Pro Lys Thr Val Ala Asp Thr Phe Glu Lys Val Val Ala Gly 
            260                 265                 270         


Ser Ile Asn Trp Pro Ala Ile Gly Ser Leu Leu Asp Tyr Val Ile Arg 
        275                 280                 285             


Pro Ala Pro Pro Pro Glu Ala Leu Thr Leu Glu Val Gln Tyr Glu Arg 
    290                 295                 300                 


Asp Lys His Leu Phe Ile Asp Phe Leu Pro Ser Val Thr Leu Gly Asp 
305                 310                 315                 320 


Thr Val Leu Val Ala Lys Pro His Arg Leu Ala Gln Tyr Asp Asn Leu 
                325                 330                 335     


Trp Arg Leu Ser Leu Arg Pro Ala Glu Thr Ala Arg Leu Arg Ala Leu 
            340                 345                 350         


Asp Gln Ala Asp Ser Gly Cys Arg Ser Leu Cys Leu Lys Ile Leu Lys 
        355                 360                 365             


Ala Ile Cys Lys Ser Thr Pro Ala Leu Gly His Leu Thr Ala Ser Gln 
    370                 375                 380                 


Leu Thr Asn Val Ile Leu His Leu Ala Gln Glu Glu Ala Asp Trp Ser 
385                 390                 395                 400 


Pro Asp Met Leu Ala Asp Arg Phe Leu Gln Ala Leu Arg Gly Leu Ile 
                405                 410                 415     


Ser Tyr Leu Glu Ala Gly Val Leu Pro Ser Ala Leu Asn Pro Lys Asp 
            420                 425                 430         


Lys Ala Leu Lys Glu Arg Ser Leu Arg His Gln Val Arg Met Met Glu 
        435                 440                 445             


Val Asp Ser Arg Leu Asn Val Ser Trp Lys Ile Gln Ser Leu Val Gly 
    450                 455                 460                 


Val Trp Trp Pro Cys Phe Leu Pro Arg Gln Ala Leu Leu Phe 
465                 470                 475             


<210>  4
<211>  1455
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gly Arg Pro Leu Arg Ile Gly Asp Gln Leu Val Leu Glu Glu 
1               5                   10                  15      


Asp Tyr Asp Glu Thr Tyr Ile Pro Ser Glu Gln Glu Ile Leu Glu Phe 
            20                  25                  30          


Ala Arg Glu Ile Gly Ile Asp Pro Ile Lys Glu Pro Glu Leu Met Trp 
        35                  40                  45              


Leu Ala Arg Glu Gly Ile Val Ala Pro Leu Pro Gly Glu Trp Lys Pro 
    50                  55                  60                  


Cys Gln Asp Ile Thr Gly Asp Ile Tyr Tyr Phe Asn Phe Ala Asn Gly 
65                  70                  75                  80  


Gln Ser Met Trp Asp His Pro Cys Asp Glu His Tyr Arg Ser Leu Val 
                85                  90                  95      


Ile Gln Glu Arg Ala Lys Leu Ser Thr Ser Gly Ala Ile Lys Lys Lys 
            100                 105                 110         


Lys Lys Lys Lys Glu Lys Lys Asp Lys Lys Asp Arg Asp Pro Pro Lys 
        115                 120                 125             


Ser Ser Leu Ala Leu Gly Ser Ser Leu Ala Pro Val His Val Pro Leu 
    130                 135                 140                 


Gly Gly Leu Ala Pro Leu Arg Gly Leu Val Asp Thr Pro Pro Ser Ala 
145                 150                 155                 160 


Leu Arg Gly Ser Gln Ser Val Ser Leu Gly Ser Ser Val Glu Ser Gly 
                165                 170                 175     


Arg Gln Leu Gly Glu Leu Met Leu Pro Ser Gln Gly Leu Lys Thr Ser 
            180                 185                 190         


Ala Tyr Thr Lys Gly Leu Leu Gly Ser Ile Tyr Glu Asp Lys Thr Ala 
        195                 200                 205             


Leu Ser Leu Leu Gly Leu Gly Glu Glu Thr Asn Glu Glu Asp Glu Glu 
    210                 215                 220                 


Glu Ser Asp Asn Gln Ser Val His Ser Ser Ser Glu Pro Leu Arg Asn 
225                 230                 235                 240 


Leu His Leu Asp Ile Gly Ala Leu Gly Gly Asp Phe Glu Tyr Glu Glu 
                245                 250                 255     


Ser Leu Arg Thr Ser Gln Pro Glu Glu Lys Lys Asp Val Ser Leu Asp 
            260                 265                 270         


Ser Asp Ala Ala Gly Pro Pro Thr Pro Cys Lys Pro Ser Ser Pro Gly 
        275                 280                 285             


Ala Asp Ser Ser Leu Ser Ser Ala Val Gly Lys Gly Arg Gln Gly Ser 
    290                 295                 300                 


Gly Ala Arg Pro Gly Leu Pro Glu Lys Glu Glu Asn Glu Lys Ser Glu 
305                 310                 315                 320 


Pro Lys Ile Cys Arg Asn Leu Val Thr Pro Lys Ala Asp Pro Thr Gly 
                325                 330                 335     


Ser Glu Pro Ala Lys Ala Ser Glu Lys Glu Ala Pro Glu Asp Thr Val 
            340                 345                 350         


Asp Ala Gly Glu Glu Gly Ser Arg Arg Glu Glu Ala Ala Lys Glu Pro 
        355                 360                 365             


Lys Lys Lys Ala Ser Ala Leu Glu Glu Gly Ser Ser Asp Ala Ser Gln 
    370                 375                 380                 


Glu Leu Glu Ile Ser Glu His Met Lys Glu Pro Gln Leu Ser Asp Ser 
385                 390                 395                 400 


Ile Ala Ser Asp Pro Lys Ser Phe His Gly Leu Asp Phe Gly Phe Arg 
                405                 410                 415     


Ser Arg Ile Ser Glu His Leu Leu Asp Val Asp Val Leu Ser Pro Val 
            420                 425                 430         


Leu Gly Gly Ala Cys Arg Gln Ala Gln Gln Pro Leu Gly Ile Glu Asp 
        435                 440                 445             


Lys Asp Asp Ser Gln Ser Ser Gln Asp Glu Leu Gln Ser Lys Gln Ser 
    450                 455                 460                 


Lys Gly Leu Glu Glu Arg Tyr His Arg Leu Ser Pro Pro Leu Pro His 
465                 470                 475                 480 


Glu Glu Arg Ala Gln Ser Pro Pro Arg Ser Leu Ala Thr Glu Glu Glu 
                485                 490                 495     


Pro Pro Gln Gly Pro Glu Gly Gln Pro Glu Trp Lys Glu Ala Glu Glu 
            500                 505                 510         


Leu Gly Glu Asp Ser Ala Ala Ser Leu Ser Leu Gln Leu Ser Leu Gln 
        515                 520                 525             


Arg Glu Gln Ala Pro Ser Pro Pro Ala Ala Cys Glu Lys Gly Lys Glu 
    530                 535                 540                 


Gln His Ser Gln Ala Glu Glu Leu Gly Pro Gly Gln Glu Glu Ala Glu 
545                 550                 555                 560 


Asp Pro Glu Glu Lys Val Ala Val Ser Pro Thr Pro Pro Val Ser Pro 
                565                 570                 575     


Glu Val Arg Ser Thr Glu Pro Val Ala Pro Pro Glu Gln Leu Ser Glu 
            580                 585                 590         


Ala Ala Leu Lys Ala Met Glu Glu Ala Val Ala Gln Val Leu Glu Gln 
        595                 600                 605             


Asp Gln Arg His Leu Leu Glu Ser Lys Gln Glu Lys Met Gln Gln Leu 
    610                 615                 620                 


Arg Glu Lys Leu Cys Gln Glu Glu Glu Glu Glu Ile Leu Arg Leu His 
625                 630                 635                 640 


Gln Gln Lys Glu Gln Ser Leu Ser Ser Leu Arg Glu Arg Leu Gln Lys 
                645                 650                 655     


Ala Ile Glu Glu Glu Glu Ala Arg Met Arg Glu Glu Glu Ser Gln Arg 
            660                 665                 670         


Leu Ser Trp Leu Arg Ala Gln Val Gln Ser Ser Thr Gln Ala Asp Glu 
        675                 680                 685             


Asp Gln Ile Arg Ala Glu Gln Glu Ala Ser Leu Gln Lys Leu Arg Glu 
    690                 695                 700                 


Glu Leu Glu Ser Gln Gln Lys Ala Glu Arg Ala Ser Leu Glu Gln Lys 
705                 710                 715                 720 


Asn Arg Gln Met Leu Glu Gln Leu Lys Glu Glu Ile Glu Ala Ser Glu 
                725                 730                 735     


Lys Ser Glu Gln Ala Ala Leu Asn Ala Ala Lys Glu Lys Ala Leu Gln 
            740                 745                 750         


Gln Leu Arg Glu Gln Leu Glu Gly Glu Arg Lys Glu Ala Val Ala Thr 
        755                 760                 765             


Leu Glu Lys Glu His Ser Ala Glu Leu Glu Arg Leu Cys Ser Ser Leu 
    770                 775                 780                 


Glu Ala Lys His Arg Glu Val Val Ser Ser Leu Gln Lys Lys Ile Gln 
785                 790                 795                 800 


Glu Ala Gln Gln Lys Glu Glu Ala Gln Leu Gln Lys Cys Leu Gly Gln 
                805                 810                 815     


Val Glu His Arg Val His Gln Lys Ser Tyr His Val Ala Gly Tyr Glu 
            820                 825                 830         


His Glu Leu Ser Ser Leu Leu Arg Glu Lys Arg Gln Glu Val Glu Gly 
        835                 840                 845             


Glu His Glu Arg Arg Leu Asp Lys Met Lys Glu Glu His Gln Gln Val 
    850                 855                 860                 


Met Ala Lys Ala Arg Glu Gln Tyr Glu Ala Glu Glu Arg Lys Gln Arg 
865                 870                 875                 880 


Ala Glu Leu Leu Gly His Leu Thr Gly Glu Leu Glu Arg Leu Gln Arg 
                885                 890                 895     


Ala His Glu Arg Glu Leu Glu Thr Val Arg Gln Glu Gln His Lys Arg 
            900                 905                 910         


Leu Glu Asp Leu Arg Arg Arg His Arg Glu Gln Glu Arg Lys Leu Gln 
        915                 920                 925             


Asp Leu Glu Leu Asp Leu Glu Thr Arg Ala Lys Asp Val Lys Ala Arg 
    930                 935                 940                 


Leu Ala Leu Leu Glu Val Gln Glu Glu Thr Ala Arg Arg Glu Lys Gln 
945                 950                 955                 960 


Gln Leu Leu Asp Val Gln Arg Gln Val Ala Leu Lys Ser Glu Glu Ala 
                965                 970                 975     


Thr Ala Thr His Gln Gln Leu Glu Glu Ala Gln Lys Glu His Thr His 
            980                 985                 990         


Leu Leu Gln Ser Asn Gln Gln Leu  Arg Glu Ile Leu Asp  Glu Leu Gln 
        995                 1000                 1005             


Ala Arg  Lys Leu Lys Leu Glu  Ser Gln Val Asp Leu  Leu Gln Ala 
    1010                 1015                 1020             


Gln Ser  Gln Gln Leu Gln Lys  His Phe Ser Ser Leu  Glu Ala Glu 
    1025                 1030                 1035             


Ala Gln  Lys Lys Gln His Leu  Leu Arg Glu Val Thr  Val Glu Glu 
    1040                 1045                 1050             


Asn Asn  Ala Ser Pro His Phe  Glu Pro Asp Leu His  Ile Glu Asp 
    1055                 1060                 1065             


Leu Arg  Lys Ser Leu Gly Thr  Asn Gln Thr Lys Glu  Val Ser Ser 
    1070                 1075                 1080             


Ser Leu  Ser Gln Ser Lys Glu  Asp Leu Tyr Leu Asp  Ser Leu Ser 
    1085                 1090                 1095             


Ser His  Asn Val Trp His Leu  Leu Ser Ala Glu Gly  Val Ala Leu 
    1100                 1105                 1110             


Arg Ser  Ala Lys Glu Phe Leu  Val Arg Gln Thr Arg  Ser Met Arg 
    1115                 1120                 1125             


Arg Arg  Gln Thr Ala Leu Lys  Ala Ala Gln Gln His  Trp Arg His 
    1130                 1135                 1140             


Glu Leu  Ala Ser Ala Gln Glu  Val Ala Lys Asp Pro  Pro Gly Ile 
    1145                 1150                 1155             


Lys Ala  Leu Glu Asp Met Arg  Lys Asn Leu Glu Lys  Glu Thr Arg 
    1160                 1165                 1170             


His Leu  Asp Glu Met Lys Ser  Ala Met Arg Lys Gly  His Asn Leu 
    1175                 1180                 1185             


Leu Lys  Lys Lys Glu Glu Lys  Leu Asn Gln Leu Glu  Ser Ser Leu 
    1190                 1195                 1200             


Trp Glu  Glu Ala Ser Asp Glu  Gly Thr Leu Gly Gly  Ser Pro Thr 
    1205                 1210                 1215             


Lys Lys  Ala Val Thr Phe Asp  Leu Ser Asp Met Asp  Ser Leu Ser 
    1220                 1225                 1230             


Ser Glu  Ser Ser Glu Ser Phe  Ser Pro Pro His Leu  Asp Ser Thr 
    1235                 1240                 1245             


Pro Ser  Leu Thr Ser Arg Lys  Ile His Gly Leu Ser  His Ser Leu 
    1250                 1255                 1260             


Arg Gln  Ile Ser Ser Gln Leu  Ser Ser Val Leu Ser  Ile Leu Asp 
    1265                 1270                 1275             


Ser Leu  Asn Pro Gln Ser Pro  Pro Pro Leu Leu Ala  Ser Met Pro 
    1280                 1285                 1290             


Ala Gln  Leu Pro Pro Arg Asp  Pro Lys Ser Thr Pro  Thr Pro Thr 
    1295                 1300                 1305             


Tyr Tyr  Gly Ser Leu Ala Arg  Phe Ser Ala Leu Ser  Ser Ala Thr 
    1310                 1315                 1320             


Pro Thr  Ser Thr Gln Trp Ala  Trp Asp Ser Gly Gln  Gly Pro Arg 
    1325                 1330                 1335             


Leu Pro  Ser Ser Val Ala Gln  Thr Val Asp Asp Phe  Leu Leu Glu 
    1340                 1345                 1350             


Lys Trp  Arg Lys Tyr Phe Pro  Ser Gly Ile Pro Leu  Leu Ser Asn 
    1355                 1360                 1365             


Ser Pro  Thr Pro Leu Glu Ser  Arg Leu Gly Tyr Met  Ser Ala Ser 
    1370                 1375                 1380             


Glu Gln  Leu Arg Leu Leu Gln  His Ser His Ser Gln  Val Pro Glu 
    1385                 1390                 1395             


Ala Gly  Ser Thr Thr Phe Gln  Gly Ile Ile Glu Ala  Asn Arg Arg 
    1400                 1405                 1410             


Trp Leu  Glu Arg Val Lys Asn  Asp Pro Arg Leu Pro  Leu Phe Ser 
    1415                 1420                 1425             


Ser Thr  Pro Lys Pro Lys Ala  Thr Leu Ser Leu Leu  Gln Leu Gly 
    1430                 1435                 1440             


Leu Asp  Glu His Asn Arg Val  Lys Val Tyr Arg Phe  
    1445                 1450                 1455 


<210>  5
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asn Phe Ser Glu Val Phe Lys Leu Ser Ser Leu Leu Cys Lys Phe 
1               5                   10                  15      


Ser Pro Asp Gly Lys Tyr Leu Ala Ser Cys Val Gln Tyr Arg Leu Val 
            20                  25                  30          


Val Arg Asp Val Asn Thr Leu Gln Ile Leu Gln Leu Tyr Thr Cys Leu 
        35                  40                  45              


Asp Gln Ile Gln His Ile Glu Trp Ser Ala Asp Ser Leu Phe Ile Leu 
    50                  55                  60                  


Cys Ala Met Tyr Lys Arg Gly Leu Val Gln Val Trp Ser Leu Glu Gln 
65                  70                  75                  80  


Pro Glu Trp His Cys Lys Ile Asp Glu Gly Ser Ala Gly Leu Val Ala 
                85                  90                  95      


Ser Cys Trp Ser Pro Asp Gly Arg His Ile Leu Asn Thr Thr Glu Phe 
            100                 105                 110         


His Leu Arg Ile Thr Val Trp Ser Leu Cys Thr Lys Ser Val Ser Tyr 
        115                 120                 125             


Ile Lys Tyr Pro Lys Ala Cys Leu Gln Gly Ile Thr Phe Thr Arg Asp 
    130                 135                 140                 


Gly Arg Tyr Met Ala Leu Ala Glu Arg Arg Asp Cys Lys Asp Tyr Val 
145                 150                 155                 160 


Ser Ile Phe Val Cys Ser Asp Trp Gln Leu Leu Arg His Phe Asp Thr 
                165                 170                 175     


Asp Thr Gln Asp Leu Thr Gly Ile Glu Trp Ala Pro Asn Gly Cys Val 
            180                 185                 190         


Leu Ala Val Trp Asp Thr Cys Leu Glu Val Arg Ile Leu Asn His Val 
        195                 200                 205             


Thr Trp Lys Met Ile Thr Glu Phe Gly His Pro Ala Ala Ile Asn Asp 
    210                 215                 220                 


Pro Lys Ile Val Val Tyr Lys Glu Ala Glu Lys Ser Pro Gln Leu Gly 
225                 230                 235                 240 


Leu Gly Cys Leu Ser Phe Pro Pro Pro Arg Ala Gly Ala Gly Pro Leu 
                245                 250                 255     


Pro Ser Ser Glu Ser Lys Tyr Glu Ile Ala Ser Val Pro Val Ser Leu 
            260                 265                 270         


Gln Thr Leu Lys Pro Val Thr Asp Arg Ala Asn Pro Lys Ile Gly Ile 
        275                 280                 285             


Gly Met Leu Ala Phe Ser Pro Asp Ser Tyr Phe Leu Ala Thr Arg Asn 
    290                 295                 300                 


Asp Asn Ile Pro Asn Ala Val Trp Val Trp Asp Ile Gln Lys Leu Arg 
305                 310                 315                 320 


Leu Phe Ala Val Leu Glu Gln Leu Ser Pro Val Arg Ala Phe Gln Trp 
                325                 330                 335     


Asp Pro Gln Gln Pro Arg Leu Ala Ile Cys Thr Gly Gly Ser Arg Leu 
            340                 345                 350         


Tyr Leu Trp Ser Pro Ala Gly Cys Met Ser Val Gln Val Pro Gly Glu 
        355                 360                 365             


Gly Asp Phe Ala Val Leu Ser Leu Cys Trp His Leu Ser Gly Asp Ser 
    370                 375                 380                 


Met Ala Leu Leu Ser Lys Asp His Phe Cys Leu Cys Phe Leu Glu Thr 
385                 390                 395                 400 


Glu Ala Val Val Gly Thr Ala Cys Arg Gln Leu Gly Gly His Thr 
                405                 410                 415 


<210>  6
<211>  733
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Asn Val Ser Glu Glu Arg Arg Lys Arg Gln Gln Asn Ile Lys 
1               5                   10                  15      


Glu Gly Leu Gln Phe Ile Gln Ser Pro Leu Ser Tyr Pro Gly Thr Gln 
            20                  25                  30          


Glu Gln Tyr Ala Val Tyr Leu Arg Ala Leu Val Arg Asn Leu Phe Asn 
        35                  40                  45              


Glu Gly Asn Asp Val Tyr Arg Glu His Asp Trp Asn Asn Ser Ile Ser 
    50                  55                  60                  


Gln Tyr Thr Glu Ala Leu Asn Ile Ala Asp Tyr Ala Lys Ser Glu Glu 
65                  70                  75                  80  


Ile Leu Ile Pro Lys Glu Ile Ile Glu Lys Leu Tyr Ile Asn Arg Ile 
                85                  90                  95      


Ala Cys Tyr Ser Asn Met Gly Phe His Asp Lys Val Leu Glu Asp Cys 
            100                 105                 110         


Asn Ile Val Leu Ser Leu Asn Ala Ser Asn Cys Lys Ala Leu Tyr Arg 
        115                 120                 125             


Lys Ser Lys Ala Leu Ser Asp Leu Gly Arg Tyr Lys Lys Ala Tyr Asp 
    130                 135                 140                 


Ala Val Ala Lys Cys Ser Leu Ala Val Pro Gln Asp Glu His Val Ile 
145                 150                 155                 160 


Lys Leu Thr Gln Glu Leu Ala Gln Lys Leu Gly Phe Lys Ile Arg Lys 
                165                 170                 175     


Ala Tyr Val Arg Ala Glu Leu Ser Leu Lys Ser Val Pro Gly Asp Gly 
            180                 185                 190         


Ala Thr Lys Ala Leu Asn His Ser Val Glu Asp Ile Glu Pro Asp Leu 
        195                 200                 205             


Leu Thr Pro Arg Gln Glu Ala Val Pro Val Val Ser Leu Pro Ala Pro 
    210                 215                 220                 


Ser Phe Ser His Glu Val Gly Ser Glu Leu Ala Ser Val Pro Val Met 
225                 230                 235                 240 


Pro Leu Thr Ser Ile Leu Pro Leu Gln Val Glu Glu Ser Ala Leu Pro 
                245                 250                 255     


Ser Ala Val Leu Ala Asn Gly Gly Lys Met Pro Phe Thr Met Pro Glu 
            260                 265                 270         


Ala Phe Leu Asp Asp Gly Asp Met Val Leu Gly Asp Glu Leu Asp Asp 
        275                 280                 285             


Leu Leu Asp Ser Ala Pro Glu Thr Asn Glu Thr Val Met Met Asn Gly 
    290                 295                 300                 


Pro Gly Ser Leu Phe Ala Ser Glu Asn Phe Leu Gly Ile Ser Ser Gln 
305                 310                 315                 320 


Pro Arg Asn Asp Phe Gly Asn Phe Phe Gly Ser Ala Val Thr Lys Pro 
                325                 330                 335     


Ser Ser Ser Val Thr Pro Arg His Pro Leu Glu Gly Thr His Glu Leu 
            340                 345                 350         


Arg Gln Ala Cys Gln Ile Cys Phe Val Lys Ser Gly Pro Lys Leu Met 
        355                 360                 365             


Asp Phe Thr Tyr His Ala Asn Ile Asp His Lys Cys Lys Lys Asp Ile 
    370                 375                 380                 


Leu Ile Gly Arg Ile Lys Asn Val Glu Asp Lys Ser Trp Lys Lys Ile 
385                 390                 395                 400 


Arg Pro Arg Pro Thr Lys Thr Asn Tyr Glu Gly Pro Tyr Tyr Ile Cys 
                405                 410                 415     


Lys Asp Val Ala Ala Glu Glu Glu Cys Arg Tyr Ser Gly His Cys Thr 
            420                 425                 430         


Phe Ala Tyr Cys Gln Glu Glu Ile Asp Val Trp Thr Leu Glu Arg Lys 
        435                 440                 445             


Gly Ala Phe Ser Arg Glu Ala Phe Phe Gly Gly Asn Gly Lys Ile Asn 
    450                 455                 460                 


Leu Thr Val Phe Lys Leu Leu Gln Glu His Leu Gly Glu Phe Ile Phe 
465                 470                 475                 480 


Leu Cys Glu Lys Cys Phe Asp His Lys Pro Arg Met Ile Ser Lys Arg 
                485                 490                 495     


Asn Lys Asp Asn Ser Thr Ala Cys Ser His Pro Val Thr Lys His Glu 
            500                 505                 510         


Phe Glu Asp Asn Lys Cys Leu Val His Ile Leu Arg Glu Thr Thr Val 
        515                 520                 525             


Lys Tyr Ser Lys Ile Arg Ser Phe His Gly Gln Cys Gln Leu Asp Leu 
    530                 535                 540                 


Cys Arg His Glu Val Arg Tyr Gly Cys Leu Arg Glu Asp Glu Cys Phe 
545                 550                 555                 560 


Tyr Ala His Ser Leu Val Glu Leu Lys Val Trp Ile Met Gln Asn Glu 
                565                 570                 575     


Thr Gly Ile Ser His Asp Ala Ile Ala Gln Glu Ser Lys Arg Tyr Trp 
            580                 585                 590         


Gln Asn Leu Glu Ala Asn Val Pro Gly Ala Gln Val Leu Gly Asn Gln 
        595                 600                 605             


Ile Met Pro Gly Phe Leu Asn Met Lys Ile Lys Phe Val Cys Ala Gln 
    610                 615                 620                 


Cys Leu Arg Asn Gly Gln Val Ile Glu Pro Asp Lys Asn Arg Lys Tyr 
625                 630                 635                 640 


Cys Ser Ala Lys Ala Arg His Ser Trp Thr Lys Asp Arg Arg Ala Met 
                645                 650                 655     


Arg Val Met Ser Ile Glu Arg Lys Lys Trp Met Asn Ile Arg Pro Leu 
            660                 665                 670         


Pro Thr Lys Lys Gln Met Pro Leu Gln Phe Asp Leu Cys Asn His Ile 
        675                 680                 685             


Ala Ser Gly Lys Lys Cys Gln Tyr Val Gly Asn Cys Ser Phe Ala His 
    690                 695                 700                 


Ser Pro Glu Glu Arg Glu Val Trp Thr Tyr Met Lys Glu Asn Gly Ile 
705                 710                 715                 720 


Gln Asp Met Glu Gln Phe Tyr Glu Leu Trp Leu Lys Ser 
                725                 730             


<210>  7
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser 
1               5                   10                  15      


Gly Asn Asp Ile Tyr Gly Asn Pro Ile Lys Arg Ile Gln Tyr Glu Ile 
            20                  25                  30          


Lys Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile 
        35                  40                  45              


Tyr Thr Ala Pro Ser Ser Ala Val Cys Gly Val Ser Leu Asp Val Gly 
    50                  55                  60                  


Gly Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys 
65                  70                  75                  80  


Met His Ile Thr Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser 
                85                  90                  95      


Thr Thr Gln Lys Lys Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
            100                 105                 110         


Cys Lys Ile Thr Arg Cys Pro Met Ile Pro Cys Tyr Ile Ser Ser Pro 
        115                 120                 125             


Asp Glu Cys Leu Trp Met Asp Trp Val Thr Glu Lys Asn Ile Asn Gly 
    130                 135                 140                 


His Gln Ala Lys Phe Phe Ala Cys Ile Lys Arg Ser Asp Gly Ser Cys 
145                 150                 155                 160 


Ala Trp Tyr Arg Gly Ala Ala Pro Pro Lys Gln Glu Phe Leu Asp Ile 
                165                 170                 175     


Glu Asp Pro 
            


<210>  8
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser His Ala Tyr Phe Ile His His Arg Val Trp Phe Arg Val Cys 
1               5                   10                  15      


Trp Leu Glu Arg His Phe Phe Arg Arg Lys Arg Lys Ser Asp Arg Val 
            20                  25                  30          


Gly Gly Ser Leu Ser Lys Leu Glu Asp Arg Gln Ala Ala Ala Ala Thr 
        35                  40                  45              


Thr Ala Ala Ala Ala Glu Pro Ser Ser Asp Val Glu Val Glu Thr His 
    50                  55                  60                  


Arg Ser Pro Gly Leu His Leu Ser Tyr Leu Ser Gly His Gln Glu Trp 
65                  70                  75                  80  


Gln Asp Lys Glu Asn Pro Glu Leu Gly Gly Thr Arg Met Pro Asp Arg 
                85                  90                  95      


Asp Ser Tyr Ala Asn Gly Thr Gly Ser Ser Gly Gly Gly Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Glu Glu Ala Ser Gly Ala Gly Val Gly Ser Gly Gly Ala 
        115                 120                 125             


Ser Ser Asp Ala Ile Cys Arg Asp Phe Leu Arg Asn Val Cys Lys Arg 
    130                 135                 140                 


Gly Lys Arg Cys Arg Tyr Arg His Pro Asp Met Ser Glu Val Ser Asn 
145                 150                 155                 160 


Leu Gly Val Ser Lys Asn Glu Phe Ile Phe Cys His Asp Phe Gln Asn 
                165                 170                 175     


Lys Glu Cys Ser Arg Pro Asn Cys Arg Phe Ile His Gly Ser Lys Glu 
            180                 185                 190         


Asp Glu Asp Gly Tyr Lys Lys Thr Gly Glu Leu Pro Pro Arg Leu Arg 
        195                 200                 205             


Gln Lys Val Ala Ala Gly Leu Gly Leu Ser Pro Ala Asp Leu Pro Asn 
    210                 215                 220                 


Gly Lys Glu Glu Val Pro Ile Cys Arg Asp Phe Leu Lys Gly Asp Cys 
225                 230                 235                 240 


Gln Arg Gly Ala Lys Cys Lys Phe Arg His Leu Gln Arg Asp Phe Glu 
                245                 250                 255     


Phe Asp Ala Arg Gly Gly Gly Gly Thr Gly Gly Gly Ser Thr Gly Ser 
            260                 265                 270         


Val Leu Pro Gly Arg Arg His Asp Leu Tyr Asp Ile Tyr Asp Leu Pro 
        275                 280                 285             


Asp Arg Gly Phe Glu Asp His Glu Pro Gly Pro Lys Arg Arg Arg Gly 
    290                 295                 300                 


Gly Cys Cys Pro Pro Asp Gly Pro His Phe Glu Ser Tyr Glu Tyr Ser 
305                 310                 315                 320 


Leu Ala Pro Pro Arg Gly Val Glu Cys Arg Leu Leu Glu Glu Glu Asn 
                325                 330                 335     


Ala Met Leu Arg Lys Arg Val Glu Glu Leu Lys Lys Gln Val Ser Asn 
            340                 345                 350         


Leu Leu Ala Thr Asn Glu Val Leu Leu Glu Gln Asn Ala Gln Phe Arg 
        355                 360                 365             


Asn Gln Ala Lys Val Ile Thr Leu Ser Ser Thr Ala Pro Ala Thr Glu 
    370                 375                 380                 


Gln Thr Leu Ala Pro Thr Val Gly Thr Val Ala Thr Phe Asn His Gly 
385                 390                 395                 400 


Ile Ala Gln Thr His Thr Thr Leu Ser Ser Gln Ala Leu Gln Pro Arg 
                405                 410                 415     


Pro Val Ser Gln Gln Glu Leu Val Ala Pro Ala Gly Ala Pro Ala Ala 
            420                 425                 430         


Pro Pro Thr Asn Ala Ala Pro Pro Ala Ala Pro Pro Pro Pro Pro Pro 
        435                 440                 445             


His Leu Thr Pro Glu Ile Thr Pro Leu Ser Ala Ala Leu Ala Gln Thr 
    450                 455                 460                 


Ile Ala Gln Gly Met Ala Pro Pro Pro Val Ser Met Ala Pro Val Ala 
465                 470                 475                 480 


Val Ser Val Ala Pro Val Ala Pro Val Ala Val Ser Met Ala Gln Pro 
                485                 490                 495     


Leu Ala Gly Ile Thr Met Ser His Thr Thr Thr Pro Met Val Thr Tyr 
            500                 505                 510         


Pro Ile Ala Ser Gln Ser Met Arg Ile Thr Ala Met Pro His 
        515                 520                 525     


<210>  9
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Ser Ala Thr Met Ala Ile Val Gln Thr Leu Pro Val Pro Leu Glu 
1               5                   10                  15      


Pro Ala Pro Glu Ala Ala Thr Ala Pro Gln Ala Pro Val Met Gly Ser 
            20                  25                  30          


Val Ser Ser Leu Ile Ser Gly Arg Pro Cys Pro Gly Gly Pro Ala Pro 
        35                  40                  45              


Pro Arg His His Gly Pro Pro Gly Pro Thr Phe Phe Arg Gln Gln Asp 
    50                  55                  60                  


Gly Leu Leu Arg Gly Gly Tyr Glu Ala Gln Glu Pro Leu Cys Pro Ala 
65                  70                  75                  80  


Val Pro Pro Arg Lys Ala Val Pro Val Thr Ser Phe Thr Tyr Ile Asn 
                85                  90                  95      


Glu Asp Phe Arg Thr Glu Ser Pro Pro Ser Pro Ser Ser Asp Val Glu 
            100                 105                 110         


Asp Ala Arg Glu Gln Arg Ala His Asn Ala His Leu Arg Gly Pro Pro 
        115                 120                 125             


Pro Lys Leu Ile Pro Val Ser Gly Lys Leu Glu Lys Asn Met Glu Lys 
    130                 135                 140                 


Ile Leu Ile Arg Pro Thr Ala Phe Lys Pro Val Leu Pro Lys Pro Arg 
145                 150                 155                 160 


Gly Ala Pro Ser Leu Pro Ser Phe Met Gly Pro Arg Ala Thr Gly Leu 
                165                 170                 175     


Ser Gly Ser Gln Gly Ser Leu Thr Gln Leu Phe Gly Gly Pro Ala Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ala Asp Lys Pro Leu Ala 
        195                 200                 205             


Phe Ser Gly Trp Ala Ser Gly Cys Pro Ser Gly Thr Leu Ser Asp Ser 
    210                 215                 220                 


Gly Arg Asn Ser Leu Ser Ser Leu Pro Thr Tyr Ser Thr Gly Gly Ala 
225                 230                 235                 240 


Glu Pro Thr Thr Ser Ser Pro Gly Gly His Leu Pro Ser His Gly Ser 
                245                 250                 255     


Gly Arg Gly Ala Leu Pro Gly Pro Ala Arg Gly Val Pro Thr Gly Pro 
            260                 265                 270         


Ser His Ser Asp Ser Gly Arg Ser Ser Ser Ser Lys Ser Thr Gly Ser 
        275                 280                 285             


Leu Gly Gly Arg Val Ala Gly Gly Leu Leu Gly Ser Gly Thr Arg Ala 
    290                 295                 300                 


Ser Pro Asp Ser Ser Ser Cys Gly Glu Arg Ser Pro Pro Pro Pro Pro 
305                 310                 315                 320 


Pro Pro Pro Ser Asp Glu Ala Leu Leu His Cys Val Leu Glu Gly Lys 
                325                 330                 335     


Leu Arg Asp Arg Glu Ala Glu Leu Gln Gln Leu Arg Asp Ser Leu Asp 
            340                 345                 350         


Glu Asn Glu Ala Thr Met Cys Gln Ala Tyr Glu Glu Arg Gln Arg His 
        355                 360                 365             


Trp Gln Arg Glu Arg Glu Ala Leu Arg Glu Asp Cys Ala Ala Gln Ala 
    370                 375                 380                 


Gln Arg Ala Gln Arg Ala Gln Gln Leu Leu Gln Leu Gln Val Phe Gln 
385                 390                 395                 400 


Leu Gln Gln Glu Lys Arg Gln Leu Gln Asp Asp Phe Ala Gln Leu Leu 
                405                 410                 415     


Gln Glu Arg Glu Gln Leu Glu Arg Arg Cys Ala Thr Leu Glu Arg Glu 
            420                 425                 430         


Gln Arg Glu Leu Gly Pro Arg Leu Glu Glu Thr Lys Trp Glu Val Cys 
        435                 440                 445             


Gln Lys Ser Gly Glu Ile Ser Leu Leu Lys Gln Gln Leu Lys Glu Ser 
    450                 455                 460                 


Gln Ala Glu Leu Val Gln Lys Gly Ser Glu Leu Val Ala Leu Arg Val 
465                 470                 475                 480 


Ala Leu Arg Glu Ala Arg Ala Thr Leu Arg Val Ser Glu Gly Arg Ala 
                485                 490                 495     


Arg Gly Leu Gln Glu Ala Ala Arg Ala Arg Glu Leu Glu Leu Glu Ala 
            500                 505                 510         


Cys Ser Gln Glu Leu Gln Arg His Arg Gln Glu Ala Glu Gln Leu Arg 
        515                 520                 525             


Glu Lys Ala Gly Gln Leu Asp Ala Glu Ala Ala Gly Leu Arg Glu Pro 
    530                 535                 540                 


Pro Val Pro Pro Ala Thr Ala Asp Pro Phe Leu Leu Ala Glu Ser Asp 
545                 550                 555                 560 


Glu Ala Lys Val Gln Arg Ala Ala Ala Gly Val Gly Gly Ser Leu Arg 
                565                 570                 575     


Ala Gln Val Glu Arg Leu Arg Val Glu Leu Gln Arg Glu Arg Arg Arg 
            580                 585                 590         


Gly Glu Glu Gln Arg Asp Ser Phe Glu Gly Glu Arg Leu Ala Trp Gln 
        595                 600                 605             


Ala Glu Lys Glu Gln Val Ile Arg Tyr Gln Lys Gln Leu Gln His Asn 
    610                 615                 620                 


Tyr Ile Gln Met Tyr Arg Arg Asn Arg Gln Leu Glu Gln Glu Leu Gln 
625                 630                 635                 640 


Gln Leu Ser Leu Glu Leu Glu Ala Arg Glu Leu Ala Asp Leu Gly Leu 
                645                 650                 655     


Ala Glu Gln Ala Pro Cys Ile Cys Leu Glu Glu Ile Thr Ala Thr Glu 
            660                 665                 670         


Ile 
    


<210>  10
<211>  1226
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Trp Gly Ser Asp Arg Leu Ala Gly Ala Gly Gly Gly Gly Ala Ala 
1               5                   10                  15      


Val Thr Val Ala Phe Thr Asn Ala Arg Asp Cys Phe Leu His Leu Pro 
            20                  25                  30          


Arg Arg Leu Val Ala Gln Leu His Leu Leu Gln Asn Gln Ala Ile Glu 
        35                  40                  45              


Val Val Trp Ser His Gln Pro Ala Phe Leu Ser Trp Val Glu Gly Arg 
    50                  55                  60                  


His Phe Ser Asp Gln Gly Glu Asn Val Ala Glu Ile Asn Arg Gln Val 
65                  70                  75                  80  


Gly Gln Lys Leu Gly Leu Ser Asn Gly Gly Gln Val Phe Leu Lys Pro 
                85                  90                  95      


Cys Ser His Val Val Ser Cys Gln Gln Val Glu Val Glu Pro Leu Ser 
            100                 105                 110         


Ala Asp Asp Trp Glu Ile Leu Glu Leu His Ala Val Ser Leu Glu Gln 
        115                 120                 125             


His Leu Leu Asp Gln Ile Arg Ile Val Phe Pro Lys Ala Ile Phe Pro 
    130                 135                 140                 


Val Trp Val Asp Gln Gln Thr Tyr Ile Phe Ile Gln Ile Val Ala Leu 
145                 150                 155                 160 


Ile Pro Ala Ala Ser Tyr Gly Arg Leu Glu Thr Asp Thr Lys Leu Leu 
                165                 170                 175     


Ile Gln Pro Lys Thr Arg Arg Ala Lys Glu Asn Thr Phe Ser Lys Ala 
            180                 185                 190         


Asp Ala Glu Tyr Lys Lys Leu His Ser Tyr Gly Arg Asp Gln Lys Gly 
        195                 200                 205             


Met Met Lys Glu Leu Gln Thr Lys Gln Leu Gln Ser Asn Thr Val Gly 
    210                 215                 220                 


Ile Thr Glu Ser Asn Glu Asn Glu Ser Glu Ile Pro Val Asp Ser Ser 
225                 230                 235                 240 


Ser Val Ala Ser Leu Trp Thr Met Ile Gly Ser Ile Phe Ser Phe Gln 
                245                 250                 255     


Ser Glu Lys Lys Gln Glu Thr Ser Trp Gly Leu Thr Glu Ile Asn Ala 
            260                 265                 270         


Phe Lys Asn Met Gln Ser Lys Val Val Pro Leu Asp Asn Ile Phe Arg 
        275                 280                 285             


Val Cys Lys Ser Gln Pro Pro Ser Ile Tyr Asn Ala Ser Ala Thr Ser 
    290                 295                 300                 


Val Phe His Lys His Cys Ala Ile His Val Phe Pro Trp Asp Gln Glu 
305                 310                 315                 320 


Tyr Phe Asp Val Glu Pro Ser Phe Thr Val Thr Tyr Gly Lys Leu Val 
                325                 330                 335     


Lys Leu Leu Ser Pro Lys Gln Gln Gln Ser Lys Thr Lys Gln Asn Val 
            340                 345                 350         


Leu Ser Pro Glu Lys Glu Lys Gln Met Ser Glu Pro Leu Asp Gln Lys 
        355                 360                 365             


Lys Ile Arg Ser Asp His Asn Glu Glu Asp Glu Lys Ala Cys Val Leu 
    370                 375                 380                 


Gln Val Val Trp Asn Gly Leu Glu Glu Leu Asn Asn Ala Ile Lys Tyr 
385                 390                 395                 400 


Thr Lys Asn Val Glu Val Leu His Leu Gly Lys Val Trp Ile Pro Asp 
                405                 410                 415     


Asp Leu Arg Lys Arg Leu Asn Ile Glu Met His Ala Val Val Arg Ile 
            420                 425                 430         


Thr Pro Val Glu Val Thr Pro Lys Ile Pro Arg Ser Leu Lys Leu Gln 
        435                 440                 445             


Pro Arg Glu Asn Leu Pro Lys Asp Ile Ser Glu Glu Asp Ile Lys Thr 
    450                 455                 460                 


Val Phe Tyr Ser Trp Leu Gln Gln Ser Thr Thr Thr Met Leu Pro Leu 
465                 470                 475                 480 


Val Ile Ser Glu Glu Glu Phe Ile Lys Leu Glu Thr Lys Asp Gly Leu 
                485                 490                 495     


Lys Glu Phe Ser Leu Ser Ile Val His Ser Trp Glu Lys Glu Lys Asp 
            500                 505                 510         


Lys Asn Ile Phe Leu Leu Ser Pro Asn Leu Leu Gln Lys Thr Thr Ile 
        515                 520                 525             


Gln Val Leu Leu Asp Pro Met Val Lys Glu Glu Asn Ser Glu Glu Ile 
    530                 535                 540                 


Asp Phe Ile Leu Pro Phe Leu Lys Leu Ser Ser Leu Gly Gly Val Asn 
545                 550                 555                 560 


Ser Leu Gly Val Ser Ser Leu Glu His Ile Thr His Ser Leu Leu Gly 
                565                 570                 575     


Arg Pro Leu Ser Arg Gln Leu Met Ser Leu Val Ala Gly Leu Arg Asn 
            580                 585                 590         


Gly Ala Leu Leu Leu Thr Gly Gly Lys Gly Ser Gly Lys Ser Thr Leu 
        595                 600                 605             


Ala Lys Ala Ile Cys Lys Glu Ala Phe Asp Lys Leu Asp Ala His Val 
    610                 615                 620                 


Glu Arg Val Asp Cys Lys Ala Leu Arg Ala Leu Asn Asp Met Ile Lys 
625                 630                 635                 640 


Glu Phe Ile Ser Met Gly Ser Leu Val Ala Leu Ile Ala Thr Ser Gln 
                645                 650                 655     


Ser Gln Gln Ser Leu His Pro Leu Leu Val Ser Ala Gln Gly Val His 
            660                 665                 670         


Ile Phe Gln Cys Val Gln His Ile Gln Pro Pro Asn Gln Glu Gln Arg 
        675                 680                 685             


Cys Glu Ile Leu Cys Asn Val Ile Lys Asn Lys Leu Asp Cys Asp Ile 
    690                 695                 700                 


Asn Lys Phe Thr Asp Leu Asp Leu Gln His Val Ala Lys Glu Thr Gly 
705                 710                 715                 720 


Gly Phe Val Ala Arg Asp Phe Thr Val Leu Val Asp Arg Ala Ile His 
                725                 730                 735     


Ser Arg Leu Ser Arg Gln Ser Ile Ser Thr Arg Glu Lys Leu Val Leu 
            740                 745                 750         


Thr Thr Leu Asp Phe Gln Lys Ala Leu Arg Gly Phe Leu Pro Ala Ser 
        755                 760                 765             


Leu Arg Ser Val Asn Leu His Lys Pro Arg Asp Leu Gly Trp Asp Lys 
    770                 775                 780                 


Ile Gly Gly Leu His Glu Val Arg Gln Ile Leu Met Asp Thr Ile Gln 
785                 790                 795                 800 


Leu Pro Ala Lys Tyr Pro Glu Leu Phe Ala Asn Leu Pro Ile Arg Gln 
                805                 810                 815     


Arg Thr Gly Ile Leu Leu Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu 
            820                 825                 830         


Leu Ala Gly Val Ile Ala Arg Glu Ser Arg Met Asn Phe Ile Ser Val 
        835                 840                 845             


Lys Gly Pro Glu Leu Leu Ser Lys Tyr Ile Gly Ala Ser Glu Gln Ala 
    850                 855                 860                 


Val Arg Asp Ile Phe Ile Arg Ala Gln Ala Ala Lys Pro Cys Ile Leu 
865                 870                 875                 880 


Phe Phe Asp Glu Phe Glu Ser Ile Ala Pro Arg Arg Gly His Asp Asn 
                885                 890                 895     


Thr Gly Val Thr Asp Arg Val Val Asn Gln Leu Leu Thr Gln Leu Asp 
            900                 905                 910         


Gly Val Glu Gly Leu Gln Gly Val Tyr Val Leu Ala Ala Thr Ser Arg 
        915                 920                 925             


Pro Asp Leu Ile Asp Pro Ala Leu Leu Arg Pro Gly Arg Leu Asp Lys 
    930                 935                 940                 


Cys Val Tyr Cys Pro Pro Pro Asp Gln Val Ser Arg Leu Glu Ile Leu 
945                 950                 955                 960 


Asn Val Leu Ser Asp Ser Leu Pro Leu Ala Asp Asp Val Asp Leu Gln 
                965                 970                 975     


His Val Ala Ser Val Thr Asp Ser Phe Thr Gly Ala Asp Leu Lys Ala 
            980                 985                 990         


Leu Leu Tyr Asn Ala Gln Leu Glu  Ala Leu His Gly Met  Leu Leu Ser 
        995                 1000                 1005             


Ser Gly  Leu Gln Asp Gly Ser  Ser Ser Ser Asp Ser  Asp Leu Ser 
    1010                 1015                 1020             


Leu Ser  Ser Met Val Phe Leu  Asn His Ser Ser Gly  Ser Asp Asp 
    1025                 1030                 1035             


Ser Ala  Gly Asp Gly Glu Cys  Gly Leu Asp Gln Ser  Leu Val Ser 
    1040                 1045                 1050             


Leu Glu  Met Ser Glu Ile Leu  Pro Asp Glu Ser Lys  Phe Asn Met 
    1055                 1060                 1065             


Tyr Arg  Leu Tyr Phe Gly Ser  Ser Tyr Glu Ser Glu  Leu Gly Asn 
    1070                 1075                 1080             


Gly Thr  Ser Ser Asp Leu Ser  Ser Gln Cys Leu Ser  Ala Pro Ser 
    1085                 1090                 1095             


Ser Met  Thr Gln Asp Leu Pro  Gly Val Pro Gly Lys  Asp Gln Leu 
    1100                 1105                 1110             


Phe Ser  Gln Pro Pro Val Leu  Arg Thr Ala Ser Gln  Glu Gly Cys 
    1115                 1120                 1125             


Gln Glu  Leu Thr Gln Glu Gln  Arg Asp Gln Leu Arg  Ala Asp Ile 
    1130                 1135                 1140             


Ser Ile  Ile Lys Gly Arg Tyr  Arg Ser Gln Ser Gly  Glu Asp Glu 
    1145                 1150                 1155             


Ser Met  Asn Gln Pro Gly Pro  Ile Lys Thr Arg Leu  Ala Ile Ser 
    1160                 1165                 1170             


Gln Ser  His Leu Met Thr Ala  Leu Gly His Thr Arg  Pro Ser Ile 
    1175                 1180                 1185             


Ser Glu  Asp Asp Trp Lys Asn  Phe Ala Glu Leu Tyr  Glu Ser Phe 
    1190                 1195                 1200             


Gln Asn  Pro Lys Arg Arg Lys  Asn Gln Ser Gly Thr  Met Phe Arg 
    1205                 1210                 1215             


Pro Gly  Gln Lys Val Thr Leu  Ala 
    1220                 1225     


<210>  11
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Arg Lys Glu Thr Pro Pro Pro Leu Val Pro Pro Ala Ala Arg Glu 
1               5                   10                  15      


Trp Asn Leu Pro Pro Asn Ala Pro Ala Cys Met Glu Arg Gln Leu Glu 
            20                  25                  30          


Ala Ala Arg Tyr Arg Ser Asp Gly Ala Leu Leu Leu Gly Ala Ser Ser 
        35                  40                  45              


Leu Ser Gly Arg Cys Trp Ala Gly Ser Leu Trp Leu Phe Lys Asp Pro 
    50                  55                  60                  


Cys Ala Ala Pro Asn Glu Gly Phe Cys Ser Ala Gly Val Gln Thr Glu 
65                  70                  75                  80  


Ala Gly Val Ala Asp Leu Thr Trp Val Gly Glu Arg Gly Ile Leu Val 
                85                  90                  95      


Ala Ser Asp Ser Gly Ala Val Glu Leu Trp Glu Leu Asp Glu Asn Glu 
            100                 105                 110         


Thr Leu Ile Val Ser Lys Phe Cys Lys Tyr Glu His Asp Asp Ile Val 
        115                 120                 125             


Ser Thr Val Ser Val Leu Ser Ser Gly Thr Gln Ala Val Ser Gly Ser 
    130                 135                 140                 


Lys Asp Ile Cys Ile Lys Val Trp Asp Leu Ala Gln Gln Val Val Leu 
145                 150                 155                 160 


Ser Ser Tyr Arg Ala His Ala Ala Gln Val Thr Cys Val Ala Ala Ser 
                165                 170                 175     


Pro His Lys Asp Ser Val Phe Leu Ser Cys Ser Glu Asp Asn Arg Ile 
            180                 185                 190         


Leu Leu Trp Asp Thr Arg Cys Pro Lys Pro Ala Ser Gln Ile Gly Cys 
        195                 200                 205             


Ser Ala Pro Gly Tyr Leu Pro Thr Ser Leu Ala Trp His Pro Gln Gln 
    210                 215                 220                 


Ser Glu Val Phe Val Phe Gly Asp Glu Asn Gly Thr Val Ser Leu Val 
225                 230                 235                 240 


Asp Thr Lys Ser Thr Ser Cys Val Leu Ser Ser Ala Val His Ser Gln 
                245                 250                 255     


Cys Val Thr Gly Leu Val Phe Ser Pro His Ser Val Pro Phe Leu Ala 
            260                 265                 270         


Ser Leu Ser Glu Asp Cys Ser Leu Ala Val Leu Asp Ser Ser Leu Ser 
        275                 280                 285             


Glu Leu Phe Arg Ser Gln Ala His Arg Asp Phe Val Arg Asp Ala Thr 
    290                 295                 300                 


Trp Ser Pro Leu Asn His Ser Leu Asp Leu Gln Val Leu Leu Ser Arg 
305                 310                 315                 320 


Leu Asp Leu Arg Gln Lys Ala Ser Pro Pro 
                325                 330 


<210>  12
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Asp Ser Glu Val Glu Ser Thr Ala Ser Ile Leu Ala Ser Val 
1               5                   10                  15      


Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Thr Arg Ala Leu Glu Glu 
            20                  25                  30          


Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro 
        35                  40                  45              


Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Thr Leu Thr Arg Arg His 
    50                  55                  60                  


Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe 
65                  70                  75                  80  


Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr 
                85                  90                  95      


Ser Thr Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr 
            100                 105                 110         


Thr Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Thr 
        115                 120                 125             


Ser Asp Asp Gly Thr Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val 
    130                 135                 140                 


Val Lys Thr Val Thr Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro 
145                 150                 155                 160 


Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln 
                165                 170                 175     


Thr Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro 
            180                 185                 190         


Tyr Val Gly Gln Ala Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr 
        195                 200                 205             


Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly 
    210                 215                 220                 


Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg 
225                 230                 235                 240 


Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val 
                245                 250                 255     


Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu 
            260                 265                 270         


His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser 
        275                 280                 285             


Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr 
    290                 295                 300                 


Ala Arg Arg Thr Gly Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser 
305                 310                 315                 320 


Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp 
                325                 330                 335     


Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser 
            340                 345                 350         


Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu 
        355                 360                 365             


Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser 
    370                 375                 380                 


Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val 
385                 390                 395                 400 


Lys Thr Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu 
                405                 410                 415     


Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu 
            420                 425                 430         


Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys 
        435                 440                 445             


Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg 
    450                 455                 460                 


Asp Met Asp Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser 
465                 470                 475                 480 


Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala 
                485                 490                 495     


Leu Thr Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro 
            500                 505                 510         


Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr 
        515                 520                 525             


Asn Thr Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala 
    530                 535                 540                 


Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe 
545                 550                 555                 560 


Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val 
                565                 570                 575     


Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg 
            580                 585                 590         


Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala 
        595                 600                 605             


Asn Asn Thr Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly 
    610                 615                 620                 


Lys Gly Lys Lys Pro Ile Glu Asp Pro Ala Asn Asp Thr Val Asp Phe 
625                 630                 635                 640 


Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr Glu Leu Leu Phe Gln Pro 
                645                 650                 655     


Glu Val Val Arg Ile Tyr Ile Ser Leu Leu Lys Glu Ser Lys Thr Pro 
            660                 665                 670         


Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile Gln Asn Leu Cys Ala Gly 
        675                 680                 685             


Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser Ala Leu Arg Gln Glu Lys 
    690                 695                 700                 


Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr Asn Glu His Glu Arg Val 
705                 710                 715                 720 


Val Lys Ala Ala Ser Gly Ala Leu Arg Asn Leu Ala Val Asp Ala Arg 
                725                 730                 735     


Asn Lys Glu Leu Ile Gly Lys His Ala Ile Pro Asn Leu Val Lys Asn 
            740                 745                 750         


Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp Asn Phe Ser Glu Asp Thr 
        755                 760                 765             


Val Ile Ser Ile Leu Asn Thr Ile Asn Glu Val Ile Ala Glu Asn Leu 
    770                 775                 780                 


Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln Gly Ile Glu Lys Leu Val 
785                 790                 795                 800 


Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu Lys Glu Val Arg Ala Ala 
                805                 810                 815     


Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr Lys Glu Leu Arg Lys Pro 
            820                 825                 830         


Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp Phe Gln Val Asn Leu Asn 
        835                 840                 845             


Asn Ala Ser Arg Ser Gln Ser Ser His Ser Tyr Asp Asp Ser Thr Leu 
    850                 855                 860                 


Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp Lys Lys Pro Asp Arg Glu 
865                 870                 875                 880 


Glu Ile Gln Met Ser Asn Met Gly Ser Asn Thr Lys Ser Leu Asp Asn 
                885                 890                 895     


Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp His Asn Arg Thr Leu Asp 
            900                 905                 910         


Arg Ser Gly Asp Leu Gly Asp Met Glu Pro Leu Lys Gly Thr Thr Pro 
        915                 920                 925             


Leu Met Gln Lys Ile 
    930             


<210>  13
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys Leu Leu Trp Gln Val Thr Val His His His Thr Trp Asn Ala 
1               5                   10                  15      


Ile Leu Leu Pro Phe Val Tyr Leu Thr Ala Gln Val Trp Ile Leu Cys 
            20                  25                  30          


Ala Ala Ile Ala Ala Ala Ala Ser Ala Gly Pro Gln Asn Cys Pro Ser 
        35                  40                  45              


Val Cys Ser Cys Ser Asn Gln Phe Ser Lys Val Val Cys Thr Arg Arg 
    50                  55                  60                  


Gly Leu Ser Glu Val Pro Gln Gly Ile Pro Ser Asn Thr Arg Tyr Leu 
65                  70                  75                  80  


Asn Leu Met Glu Asn Asn Ile Gln Met Ile Gln Ala Asp Thr Phe Arg 
                85                  90                  95      


His Leu His His Leu Glu Val Leu Gln Leu Gly Arg Asn Ser Ile Arg 
            100                 105                 110         


Gln Ile Glu Val Gly Ala Phe Asn Gly Leu Ala Ser Leu Asn Thr Leu 
        115                 120                 125             


Glu Leu Phe Asp Asn Trp Leu Thr Val Ile Pro Ser Gly Ala Phe Glu 
    130                 135                 140                 


Tyr Leu Ser Lys Leu Arg Glu Leu Trp Leu Arg Asn Asn Pro Ile Glu 
145                 150                 155                 160 


Ser Ile Pro Ser Tyr Ala Phe Asn Arg Val Pro Ser Leu Met Arg Leu 
                165                 170                 175     


Asp Leu Gly Glu Leu Lys Lys Leu Glu Tyr Ile Ser Glu Gly Ala Phe 
            180                 185                 190         


Glu Gly Leu Phe Asn Leu Lys Tyr Leu Asn Leu Gly Met Cys Asn Ile 
        195                 200                 205             


Lys Asp Met Pro Asn Leu Thr Pro Leu Val Gly Leu Glu Glu Leu Glu 
    210                 215                 220                 


Met Ser Gly Asn His Phe Pro Glu Ile Arg Pro Gly Ser Phe His Gly 
225                 230                 235                 240 


Leu Ser Ser Leu Lys Lys Leu Trp Val Met Asn Ser Gln Val Ser Leu 
                245                 250                 255     


Ile Glu Arg Asn Ala Phe Asp Gly Leu Ala Ser Leu Val Glu Leu Asn 
            260                 265                 270         


Leu Ala His Asn Asn Leu Ser Ser Leu Pro His Asp Leu Phe Thr Pro 
        275                 280                 285             


Leu Arg Tyr Leu Val Glu Leu His Leu His His Asn Pro Trp Asn Cys 
    290                 295                 300                 


Asp Cys Asp Ile Leu Trp Leu Ala Trp Trp Leu Arg Glu Tyr Ile Pro 
305                 310                 315                 320 


Thr Asn Ser Thr Cys Cys Gly Arg Cys His Ala Pro Met His Met Arg 
                325                 330                 335     


Gly Arg Tyr Leu Val Glu Val Asp Gln Ala Ser Phe Gln Cys Ser Ala 
            340                 345                 350         


Pro Phe Ile Met Asp Ala Pro Arg Asp Leu Asn Ile Ser Glu Gly Arg 
        355                 360                 365             


Met Ala Glu Leu Lys Cys Arg Thr Pro Pro Met Ser Ser Val Lys Trp 
    370                 375                 380                 


Leu Leu Pro Asn Gly Thr Val Leu Ser His Ala Ser Arg His Pro Arg 
385                 390                 395                 400 


Ile Ser Val Leu Asn Asp Gly Thr Leu Asn Phe Ser His Val Leu Leu 
                405                 410                 415     


Ser Asp Thr Gly Val Tyr Thr Cys Met Val Thr Asn Val Ala Gly Asn 
            420                 425                 430         


Ser Asn Ala Ser Ala Tyr Leu Asn Val Ser Thr Ala Glu Leu Asn Thr 
        435                 440                 445             


Ser Asn Tyr Ser Phe Phe Thr Thr Val Thr Val Glu Thr Thr Glu Ile 
    450                 455                 460                 


Ser Pro Glu Asp Thr Thr Arg Lys Tyr Lys Pro Val Pro Thr Thr Ser 
465                 470                 475                 480 


Thr Gly Tyr Gln Pro Ala Tyr Thr Thr Ser Thr Thr Val Leu Ile Gln 
                485                 490                 495     


Thr Thr Arg Val Pro Lys Gln Val Ala Val Pro Ala Thr Asp Thr Thr 
            500                 505                 510         


Asp Lys Met Gln Thr Ser Leu Asp Glu Val Met Lys Thr Thr Lys Ile 
        515                 520                 525             


Ile Ile Gly Cys Phe Val Ala Val Thr Leu Leu Ala Ala Ala Met Leu 
    530                 535                 540                 


Ile Val Phe Tyr Lys Leu Arg Lys Arg His Gln Gln Arg Ser Thr Val 
545                 550                 555                 560 


Thr Ala Ala Arg Thr Val Glu Ile Ile Gln Val Asp Glu Asp Ile Pro 
                565                 570                 575     


Ala Ala Thr Ser Ala Ala Ala Thr Ala Ala Pro Ser Gly Val Ser Gly 
            580                 585                 590         


Glu Gly Ala Val Val Leu Pro Thr Ile His Asp His Ile Asn Tyr Asn 
        595                 600                 605             


Thr Tyr Lys Pro Ala His Gly Ala His Trp Thr Glu Asn Ser Leu Gly 
    610                 615                 620                 


Asn Ser Leu His Pro Thr Val Thr Thr Ile Ser Glu Pro Tyr Ile Ile 
625                 630                 635                 640 


Gln Thr His Thr Lys Asp Lys Val Gln Glu Thr Gln Ile 
                645                 650             


<210>  14
<211>  1749
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Asp Thr Lys Val Lys Val Ala Val Arg Val Arg Pro Met Asn 
1               5                   10                  15      


Arg Arg Glu Leu Glu Leu Asn Thr Lys Cys Val Val Glu Met Glu Gly 
            20                  25                  30          


Asn Gln Thr Val Leu His Pro Pro Pro Ser Asn Thr Lys Gln Gly Glu 
        35                  40                  45              


Arg Lys Pro Pro Lys Val Phe Ala Phe Asp Tyr Cys Phe Trp Ser Met 
    50                  55                  60                  


Asp Glu Ser Asn Thr Thr Lys Tyr Ala Gly Gln Glu Val Val Phe Lys 
65                  70                  75                  80  


Cys Leu Gly Glu Gly Ile Leu Glu Lys Ala Phe Gln Gly Tyr Asn Ala 
                85                  90                  95      


Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Ser Phe Ser Met 
            100                 105                 110         


Met Gly His Ala Glu Gln Leu Gly Leu Ile Pro Arg Leu Cys Cys Ala 
        115                 120                 125             


Leu Phe Lys Arg Ile Ser Leu Glu Gln Asn Glu Ser Gln Thr Phe Lys 
    130                 135                 140                 


Val Glu Val Ser Tyr Met Glu Ile Tyr Asn Glu Lys Val Arg Asp Leu 
145                 150                 155                 160 


Leu Asp Pro Lys Gly Ser Arg Gln Ser Leu Lys Val Arg Glu His Lys 
                165                 170                 175     


Val Leu Gly Pro Tyr Val Asp Gly Leu Ser Gln Leu Ala Val Thr Ser 
            180                 185                 190         


Phe Glu Asp Ile Glu Ser Leu Met Ser Glu Gly Asn Lys Ser Arg Thr 
        195                 200                 205             


Val Ala Ala Thr Asn Met Asn Glu Glu Ser Ser Arg Ser His Ala Val 
    210                 215                 220                 


Phe Asn Ile Ile Ile Thr Gln Thr Leu Tyr Asp Leu Gln Ser Gly Asn 
225                 230                 235                 240 


Ser Gly Glu Lys Val Ser Lys Val Ser Leu Val Asp Leu Ala Gly Ser 
                245                 250                 255     


Glu Arg Val Ser Lys Thr Gly Ala Ala Gly Glu Arg Leu Lys Glu Gly 
            260                 265                 270         


Ser Asn Ile Asn Lys Ser Leu Thr Thr Leu Gly Leu Val Ile Ser Ser 
        275                 280                 285             


Leu Ala Asp Gln Ala Ala Gly Lys Gly Lys Ser Lys Phe Val Pro Tyr 
    290                 295                 300                 


Arg Asp Ser Val Leu Thr Trp Leu Leu Lys Asp Asn Leu Gly Gly Asn 
305                 310                 315                 320 


Ser Gln Thr Ser Met Ile Ala Thr Ile Ser Pro Ala Ala Asp Asn Tyr 
                325                 330                 335     


Glu Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys Arg Ile 
            340                 345                 350         


Val Asn His Ala Val Val Asn Glu Asp Pro Asn Ala Lys Val Ile Arg 
        355                 360                 365             


Glu Leu Arg Glu Glu Val Glu Lys Leu Arg Glu Gln Leu Ser Gln Ala 
    370                 375                 380                 


Glu Ala Met Lys Ala Pro Glu Leu Lys Glu Lys Leu Glu Glu Ser Glu 
385                 390                 395                 400 


Lys Leu Ile Lys Glu Leu Thr Val Thr Trp Glu Glu Lys Leu Arg Lys 
                405                 410                 415     


Thr Glu Glu Ile Ala Gln Glu Arg Gln Arg Gln Leu Glu Ser Met Gly 
            420                 425                 430         


Ile Ser Leu Glu Met Ser Gly Ile Lys Val Gly Asp Asp Lys Cys Tyr 
        435                 440                 445             


Leu Val Asn Leu Asn Ala Asp Pro Ala Leu Asn Glu Leu Leu Val Tyr 
    450                 455                 460                 


Tyr Leu Lys Asp His Thr Arg Val Gly Ala Asp Thr Ser Gln Asp Ile 
465                 470                 475                 480 


Gln Leu Phe Gly Ile Gly Ile Gln Pro Gln His Cys Glu Ile Asp Ile 
                485                 490                 495     


Ala Ser Asp Gly Asp Val Thr Leu Thr Pro Lys Glu Asn Ala Arg Ser 
            500                 505                 510         


Cys Val Asn Gly Thr Leu Val Cys Ser Thr Thr Gln Leu Trp His Gly 
        515                 520                 525             


Asp Arg Ile Leu Trp Gly Asn Asn His Phe Phe Arg Ile Asn Leu Pro 
    530                 535                 540                 


Lys Arg Lys Arg Arg Asp Trp Leu Lys Asp Phe Glu Lys Glu Thr Gly 
545                 550                 555                 560 


Pro Pro Glu His Asp Leu Asp Ala Ala Ser Glu Ala Ser Ser Glu Pro 
                565                 570                 575     


Asp Tyr Asn Tyr Glu Phe Ala Gln Met Glu Val Ile Met Lys Thr Leu 
            580                 585                 590         


Asn Ser Asn Asp Pro Val Gln Asn Val Val Gln Val Leu Glu Lys Gln 
        595                 600                 605             


Tyr Leu Glu Glu Lys Arg Ser Ala Leu Glu Glu Gln Arg Leu Met Tyr 
    610                 615                 620                 


Glu Arg Glu Leu Glu Gln Leu Arg Gln Gln Leu Ser Pro Asp Arg Gln 
625                 630                 635                 640 


Pro Gln Ser Ser Gly Pro Asp Arg Leu Ala Tyr Ser Ser Gln Thr Ala 
                645                 650                 655     


Gln Gln Lys Val Thr Gln Trp Ala Glu Glu Arg Asp Glu Leu Phe Arg 
            660                 665                 670         


Gln Ser Leu Ala Lys Leu Arg Glu Gln Leu Val Lys Ala Asn Thr Leu 
        675                 680                 685             


Val Arg Glu Ala Asn Phe Leu Ala Glu Glu Met Ser Lys Leu Thr Asp 
    690                 695                 700                 


Tyr Gln Val Thr Leu Gln Ile Pro Ala Ala Asn Leu Ser Ala Asn Arg 
705                 710                 715                 720 


Lys Arg Gly Ala Ile Val Ser Glu Pro Ala Ile Gln Val Arg Arg Lys 
                725                 730                 735     


Gly Lys Ser Thr Gln Val Trp Thr Ile Glu Lys Leu Glu Asn Lys Leu 
            740                 745                 750         


Ile Asp Met Arg Asp Leu Tyr Gln Glu Trp Lys Glu Lys Val Pro Glu 
        755                 760                 765             


Ala Lys Arg Leu Tyr Gly Lys Arg Gly Asp Pro Phe Tyr Glu Ala Gln 
    770                 775                 780                 


Glu Asn His Asn Leu Ile Gly Val Ala Asn Val Phe Leu Glu Cys Leu 
785                 790                 795                 800 


Phe Cys Asp Val Lys Leu Gln Tyr Ala Val Pro Ile Ile Ser Gln Gln 
                805                 810                 815     


Gly Glu Val Ala Gly Arg Leu His Val Glu Val Met Arg Val Thr Gly 
            820                 825                 830         


Ala Val Pro Glu Arg Val Val Glu Asp Asp Ser Ser Glu Asn Ser Ser 
        835                 840                 845             


Glu Ser Gly Ser Leu Glu Val Val Asp Ser Ser Gly Glu Ile Ile His 
    850                 855                 860                 


Arg Val Lys Lys Leu Thr Cys Arg Val Lys Ile Lys Glu Ala Thr Gly 
865                 870                 875                 880 


Leu Pro Leu Asn Leu Ser Asn Phe Val Phe Cys Gln Tyr Thr Phe Trp 
                885                 890                 895     


Asp Gln Cys Glu Ser Thr Val Ala Ala Pro Val Val Asp Pro Glu Val 
            900                 905                 910         


Pro Ser Pro Gln Ser Lys Asp Ala Gln Tyr Thr Val Thr Phe Ser His 
        915                 920                 925             


Cys Lys Asp Tyr Val Val Asn Val Thr Glu Glu Phe Leu Glu Phe Ile 
    930                 935                 940                 


Ser Asp Gly Ala Leu Ala Ile Glu Val Trp Gly His Arg Cys Ala Gly 
945                 950                 955                 960 


Asn Gly Ser Ser Ile Trp Glu Val Asp Ser Leu His Ala Lys Thr Arg 
                965                 970                 975     


Thr Leu His Asp Arg Trp Asn Glu Val Thr Arg Arg Ile Glu Met Trp 
            980                 985                 990         


Ile Ser Ile Leu Glu Leu Asn Glu  Leu Gly Glu Tyr Ala  Ala Val Glu 
        995                 1000                 1005             


Leu His  Gln Ala Lys Asp Val  Asn Thr Gly Gly Ile  Phe Gln Leu 
    1010                 1015                 1020             


Arg Gln  Gly His Ser Arg Arg  Val Gln Val Thr Val  Lys Pro Val 
    1025                 1030                 1035             


Gln His  Ser Gly Thr Leu Pro  Leu Met Val Glu Ala  Ile Leu Ser 
    1040                 1045                 1050             


Val Ser  Ile Gly Cys Val Thr  Ala Arg Ser Thr Lys  Leu Gln Arg 
    1055                 1060                 1065             


Gly Leu  Asp Ser Tyr Gln Glu  Glu Asp Leu Asn Cys  Val Arg Glu 
    1070                 1075                 1080             


Arg Trp  Ser Asp Ala Leu Ile  Lys Arg Arg Glu Tyr  Leu Asp Glu 
    1085                 1090                 1095             


Gln Ile  Lys Lys Val Ser Asn  Lys Thr Glu Lys Thr  Glu Asp Asp 
    1100                 1105                 1110             


Val Glu  Arg Glu Ala Gln Leu  Val Glu Gln Trp Val  Gly Leu Thr 
    1115                 1120                 1125             


Glu Glu  Arg Asn Ala Val Leu  Val Pro Ala Pro Gly  Ser Gly Ile 
    1130                 1135                 1140             


Pro Gly  Ala Pro Ala Asp Trp  Ile Pro Pro Pro Gly  Met Glu Thr 
    1145                 1150                 1155             


His Ile  Pro Val Leu Phe Leu  Asp Leu Asn Ala Asp  Asp Leu Ser 
    1160                 1165                 1170             


Ala Asn  Glu Gln Leu Val Gly  Pro His Ala Ser Gly  Val Asn Ser 
    1175                 1180                 1185             


Ile Leu  Pro Lys Glu His Gly  Ser Gln Phe Phe Tyr  Leu Pro Ile 
    1190                 1195                 1200             


Ile Lys  His Ser Asp Asp Glu  Val Ser Ala Thr Ala  Ser Trp Asp 
    1205                 1210                 1215             


Ser Ser  Val His Asp Ser Val  His Leu Asn Arg Val  Thr Pro Gln 
    1220                 1225                 1230             


Asn Glu  Arg Ile Tyr Leu Ile  Val Lys Thr Thr Val  Gln Leu Ser 
    1235                 1240                 1245             


His Pro  Ala Ala Met Glu Leu  Val Leu Arg Lys Arg  Ile Ala Ala 
    1250                 1255                 1260             


Asn Ile  Tyr Asn Lys Gln Ser  Phe Thr Gln Ser Leu  Lys Arg Arg 
    1265                 1270                 1275             


Ile Ser  Leu Lys Asn Ile Phe  Tyr Ser Cys Gly Val  Thr Tyr Glu 
    1280                 1285                 1290             


Ile Val  Ser Asn Ile Pro Lys  Ala Thr Glu Glu Ile  Glu Asp Arg 
    1295                 1300                 1305             


Glu Thr  Leu Ala Leu Leu Ala  Ala Arg Ser Glu Asn  Glu Gly Thr 
    1310                 1315                 1320             


Ser Asp  Gly Glu Thr Tyr Ile  Glu Lys Tyr Thr Arg  Gly Val Leu 
    1325                 1330                 1335             


Gln Val  Glu Asn Ile Leu Ser  Leu Glu Arg Leu Arg  Gln Ala Val 
    1340                 1345                 1350             


Thr Val  Lys Glu Ala Leu Ser  Thr Lys Ala Arg His  Ile Arg Arg 
    1355                 1360                 1365             


Ser Leu  Ser Thr Pro Asn Val  His Asn Val Ser Ser  Ser Arg Pro 
    1370                 1375                 1380             


Asp Leu  Ser Gly Phe Asp Glu  Asp Asp Lys Gly Trp  Pro Glu Asn 
    1385                 1390                 1395             


Gln Leu  Asp Met Ser Asp Tyr  Ser Ser Ser Tyr Gln  Asp Val Ala 
    1400                 1405                 1410             


Cys Tyr  Gly Thr Leu Pro Arg  Asp Ser Pro Arg Arg  Asn Lys Glu 
    1415                 1420                 1425             


Gly Cys  Thr Ser Glu Thr Pro  His Ala Leu Thr Val  Ser Pro Phe 
    1430                 1435                 1440             


Lys Ala  Phe Ser Pro Gln Pro  Pro Lys Phe Phe Lys  Pro Leu Met 
    1445                 1450                 1455             


Pro Val  Lys Glu Glu His Lys  Lys Arg Ile Ala Leu  Glu Ala Arg 
    1460                 1465                 1470             


Pro Leu  Leu Ser Gln Glu Asp  Ser Glu Glu Glu Glu  Asn Glu Leu 
    1475                 1480                 1485             


Glu Ala  Ile Asn Arg Lys Leu  Ile Ser Ser Gln Pro  Tyr Val Pro 
    1490                 1495                 1500             


Val Glu  Phe Ala Asp Phe Ser  Val Tyr Asn Ala Ser  Leu Glu Asn 
    1505                 1510                 1515             


Arg Glu  Trp Phe Ser Ser Lys  Val Asp Leu Ser Asn  Ser Arg Val 
    1520                 1525                 1530             


Leu Glu  Lys Glu Val Ser Arg  Ser Pro Thr Thr Ser  Ser Ile Thr 
    1535                 1540                 1545             


Ser Gly  Tyr Phe Ser His Ser  Ala Ser Asn Ala Thr  Leu Ser Asp 
    1550                 1555                 1560             


Met Val  Val Pro Ser Ser Asp  Ser Ser Asp Gln Leu  Ala Ile Gln 
    1565                 1570                 1575             


Thr Lys  Asp Ala Asp Ser Thr  Glu His Ser Thr Pro  Ser Leu Val 
    1580                 1585                 1590             


His Asp  Phe Arg Pro Ser Ser  Asn Lys Glu Leu Thr  Glu Val Glu 
    1595                 1600                 1605             


Lys Gly  Leu Val Lys Asp Lys  Ile Ile Val Val Pro  Leu Lys Glu 
    1610                 1615                 1620             


Asn Ser  Ala Leu Ala Lys Gly  Ser Pro Ser Ser Gln  Ser Ile Pro 
    1625                 1630                 1635             


Glu Lys  Asn Ser Lys Ser Leu  Cys Arg Thr Gly Ser  Cys Ser Glu 
    1640                 1645                 1650             


Leu Asp  Ala Cys Pro Ser Lys  Ile Ser Gln Pro Ala  Arg Gly Phe 
    1655                 1660                 1665             


Cys Pro  Arg Glu Val Thr Val  Glu His Thr Thr Asn  Ile Leu Glu 
    1670                 1675                 1680             


Asp His  Ser Phe Thr Glu Phe  Met Gly Val Ser Glu  Gly Lys Asp 
    1685                 1690                 1695             


Phe Asp  Gly Leu Thr Asp Ser  Ser Ala Gly Glu Leu  Ser Ser Arg 
    1700                 1705                 1710             


Arg Ser  Leu Pro Asn Lys Thr  Gly Gly Lys Thr Val  Ser Asp Gly 
    1715                 1720                 1725             


Leu His  His Pro Ser Gln Leu  His Ser Lys Leu Glu  Asn Asp Gln 
    1730                 1735                 1740             


Gly Gly  Thr Thr Ser Arg 
    1745                 


<210>  15
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Pro Pro Ala Glu Lys Pro Gly Glu Ala Gly Gly Leu Gln Ile 
1               5                   10                  15      


Thr Pro Gln Leu Leu Lys Ser Arg Thr Gly Glu Phe Ser Leu Glu Ser 
            20                  25                  30          


Ile Leu Leu Leu Lys Leu Arg Gly Leu Gly Leu Ala Asp Leu Gly Cys 
        35                  40                  45              


Leu Gly Glu Cys Leu Gly Leu Glu Trp Leu Asp Leu Ser Gly Asn Ala 
    50                  55                  60                  


Leu Thr His Leu Gly Pro Leu Ala Ser Leu Arg Gln Leu Ala Val Leu 
65                  70                  75                  80  


Asn Val Ser Asn Asn Arg Leu Thr Gly Leu Glu Pro Leu Ala Thr Cys 
                85                  90                  95      


Glu Asn Leu Gln Ser Leu Asn Ala Ala Gly Asn Leu Leu Ala Thr Pro 
            100                 105                 110         


Gly Gln Leu Gln Cys Leu Ala Gly Leu Pro Cys Leu Glu Tyr Leu Arg 
        115                 120                 125             


Leu Arg Asp Pro Leu Ala Arg Leu Ser Asn Pro Leu Cys Ala Ser Pro 
    130                 135                 140                 


Ser Tyr Trp Ala Ala Val Arg Glu Leu Leu Pro Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp Gly Glu Arg Val Ile Gly Arg Gly Ser Glu Phe Tyr Gln Leu Cys 
                165                 170                 175     


Arg Asp Leu Asp Ser Ser Leu Arg Pro Ser Ser Ser Pro Gly Pro Arg 
            180                 185                 190         


Ala Thr Glu Ala Gln Pro Trp Val Glu Pro Gly Tyr Trp Glu Ser Trp 
        195                 200                 205             


Pro Ser Arg Ser Ser Ser Ile Leu Glu Glu Ala Cys Arg Gln Phe Gln 
    210                 215                 220                 


Asp Thr Leu Gln Glu Cys Trp Asp Leu Asp Arg Gln Ala Ser Asp Ser 
225                 230                 235                 240 


Leu Ala Gln Ala Glu Gln Val Leu Ser Ser Ala Gly Pro Thr Ser Ser 
                245                 250                 255     


Phe Val Phe 
            


<210>  16
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ser Ser Thr Ser Leu Pro Ala Pro Gly Ser Arg Pro Lys Lys 
1               5                   10                  15      


Pro Leu Gly Lys Met Ala Asp Trp Phe Arg Gln Thr Leu Leu Lys Lys 
            20                  25                  30          


Pro Lys Lys Arg Pro Asn Ser Pro Glu Ser Thr Ser Ser Asp Ala Ser 
        35                  40                  45              


Gln Pro Thr Ser Gln Asp Asn Pro Leu Pro Pro Ser Leu Ser Ser Val 
    50                  55                  60                  


Thr Ser Pro Ser Leu Pro Pro Thr His Ala Ser Asp Ser Gly Ser Ser 
65                  70                  75                  80  


Arg Trp Ser Lys Asp Tyr Asp Val Cys Val Cys His Ser Glu Glu Asp 
                85                  90                  95      


Leu Val Ala Ala Gln Asp Leu Val Ser Tyr Leu Glu Gly Ser Thr Ala 
            100                 105                 110         


Ser Leu Arg Cys Phe Leu Gln Leu Arg Asp Ala Thr Pro Gly Gly Ala 
        115                 120                 125             


Ile Val Ser Glu Leu Cys Gln Ala Leu Ser Ser Ser His Cys Arg Val 
    130                 135                 140                 


Leu Leu Ile Thr Pro Gly Phe Leu Gln Asp Pro Trp Cys Lys Tyr Gln 
145                 150                 155                 160 


Met Leu Gln Ala Leu Thr Glu Ala Pro Gly Ala Glu Gly Cys Thr Ile 
                165                 170                 175     


Pro Leu Leu Ser Gly Leu Ser Arg Ala Ala Tyr Pro Pro Glu Leu Arg 
            180                 185                 190         


Phe Met Tyr Tyr Val Asp Gly Arg Gly Pro Asp Gly Gly Phe Arg Gln 
        195                 200                 205             


Val Lys Glu Ala Val Met Arg Tyr Leu Gln Thr Leu Ser 
    210                 215                 220     


<210>  17
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gly Lys Glu Ile Pro Thr Asp Ala Pro Trp Glu Ala Gln His Ala 
1               5                   10                  15      


Asp Lys Trp Asp Lys Met Thr Met Lys Glu Leu Ile Asp Lys Ile Cys 
            20                  25                  30          


Trp Thr Lys Thr Ala Arg Arg Phe Ala Tyr Leu Phe Val Asn Ile Asn 
        35                  40                  45              


Val Thr Ser Glu Pro His Glu Val Ser Ala Leu Trp Phe Leu Trp Tyr 
    50                  55                  60                  


Val Lys Gln Cys Gly Gly Thr Thr Arg Ile Phe Ser Val Thr Asn Gly 
65                  70                  75                  80  


Gly Gln Glu Arg Lys Phe Val Gly Gly Ser Gly Gln Val Ser Glu Arg 
                85                  90                  95      


Ile Met Asp Leu Leu Gly Asp Gln Val Lys Leu Asn His Pro Val Thr 
            100                 105                 110         


His Val Asp Gln Ser Ser Asp Asn Ile Ile Ile Glu Thr Leu Asn His 
        115                 120                 125             


Glu His Tyr Glu Cys Lys Tyr Val Ile Asn Ala Ile Pro Pro Thr Leu 
    130                 135                 140                 


Thr Ala Lys Ile His Phe Arg Pro Glu Leu Pro Ala Glu Arg Asn Gln 
145                 150                 155                 160 


Leu Ile Gln Arg Leu Pro Met Gly Ala Val Ile Lys Cys Met Met Tyr 
                165                 170                 175     


Tyr Lys Glu Ala Phe Trp Lys Lys Lys Asp Tyr Cys Gly Cys Met Ile 
            180                 185                 190         


Ile Glu Asp Glu Asp Ala Pro Ile Ser Ile Thr Leu Asp Asp Thr Lys 
        195                 200                 205             


Pro Asp Gly Ser Leu Pro Ala Ile Met Gly Phe Ile Leu Ala Arg Lys 
    210                 215                 220                 


Ala Asp Arg Leu Ala Lys Leu His Lys Glu Ile Arg Lys Lys Lys Ile 
225                 230                 235                 240 


Cys Glu Leu Tyr Ala Lys Val Leu Gly Ser Gln Glu Ala Leu His Pro 
                245                 250                 255     


Val His Tyr Glu Glu Lys Asn Trp Cys Glu Glu Gln Tyr Ser Gly Gly 
            260                 265                 270         


Cys Tyr Thr Ala Tyr Phe Pro Pro Gly Ile Met Thr Gln Tyr Gly Arg 
        275                 280                 285             


Val Ile Arg Gln Pro Val Gly Arg Ile Phe Phe Ala Gly Thr Glu Thr 
    290                 295                 300                 


Ala Thr Lys Trp Ser Gly Tyr Met Glu Gly Ala Val Glu Ala Gly Glu 
305                 310                 315                 320 


Arg Ala Ala Arg Glu Val Leu Asn Gly Leu Gly Lys Val Thr Glu Lys 
                325                 330                 335     


Asp Ile Trp Val Gln Glu Pro Glu Ser Lys Asp Val Pro Ala Val Glu 
            340                 345                 350         


Ile Thr His Thr Phe Trp Glu Arg Asn Leu Pro Ser Val Ser Gly Leu 
        355                 360                 365             


Leu Lys Ile Ile Gly Phe Ser Thr Ser Val Thr Ala Leu Gly Phe Val 
    370                 375                 380                 


Leu Tyr Lys Tyr Lys Leu Leu Pro Arg Ser 
385                 390                 


<210>  18
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Val Phe Ser Met Ala Gln Pro Met Ala Ser Ser Ser Thr Glu Pro 
1               5                   10                  15      


Tyr Leu Cys Leu Ala Ala Ala Gly Glu Asn Pro Ser Gly Lys Ser Leu 
            20                  25                  30          


Ala Ser Ala Ile Ser Gly Lys Ile Pro Ser Pro Leu Ser Ser Ser Tyr 
        35                  40                  45              


Lys Pro Met Leu Asn Asn Asn Ser Phe Met Trp Pro Asn Ser Thr Pro 
    50                  55                  60                  


Val Pro Leu Leu Gln Thr Thr Gln Gly Leu Lys Pro Val Ser Pro Pro 
65                  70                  75                  80  


Lys Ile Gln Pro Val Ser Trp His His Ser Gly Gly Thr Gly Asp Cys 
                85                  90                  95      


Ala Pro Gln Pro Val Asp His Lys Val Pro Lys Ser Ile Gly Thr Val 
            100                 105                 110         


Pro Ala Asp Ala Ser Ala His Ile Ala Leu Ser Thr Ala Ser Ser His 
        115                 120                 125             


Asp Thr Ser Thr Thr Ser Val Ala Ser Ser Trp Tyr Asn Arg Asn Asn 
    130                 135                 140                 


Leu Ala Met Arg Ala Glu Pro Leu Ser Cys Ala Leu Asp Asp Ser Ser 
145                 150                 155                 160 


Asp Ser Gln Asp Pro Thr Lys Glu Ile Arg Phe Thr Glu Ala Val Arg 
                165                 170                 175     


Lys Leu Thr Ala Arg Gly Phe Glu Lys Met Pro Arg Gln Gly Cys Gln 
            180                 185                 190         


Leu Glu Gln Ser Ser Phe Leu Asn Pro Ser Phe Gln Trp Asn Val Leu 
        195                 200                 205             


Asn Arg Ser Arg Arg Trp Lys Pro Pro Ala Val Asn Gln Gln Phe Pro 
    210                 215                 220                 


Gln Glu Asp Ala Gly Ser Val Arg Arg Val Leu Pro Gly Ala Ser Asp 
225                 230                 235                 240 


Thr Leu Gly Leu Asp Asn Thr Val Phe Cys Thr Lys Arg Ile Ser Ile 
                245                 250                 255     


His Leu Leu Ala Ser His Ala Ser Gly Leu Asn His Asn Pro Ala Cys 
            260                 265                 270         


Glu Ser Val Ile Asp Ser Ser Ala Phe Gly Glu Gly Lys Ala Pro Gly 
        275                 280                 285             


Pro Pro Phe Pro Gln Thr Leu Gly Ile Ala Asn Val Ala Thr Arg Leu 
    290                 295                 300                 


Ser Ser Ile Gln Leu Gly Gln Ser Glu Lys Glu Arg Pro Glu Glu Ala 
305                 310                 315                 320 


Arg Glu Leu Asp Ser Ser Asp Arg Asp Ile Ser Ser Ala Thr Asp Leu 
                325                 330                 335     


Gln Pro Asp Gln Ala Glu Thr Glu Asp Thr Glu Glu Glu Leu Val Asp 
            340                 345                 350         


Gly Leu Glu Asp Cys Cys Ser Arg Asp Glu Asn Glu Glu Glu Glu Gly 
        355                 360                 365             


Asp Ser Glu Cys Ser Ser Leu Ser Ala Val Ser Pro Gly Glu Ser Val 
    370                 375                 380                 


Ala Met Ile Ser Arg Ser Cys Met Glu Ile Leu Thr Lys Pro Leu Ser 
385                 390                 395                 400 


Asn His Glu Lys Val Val Arg Pro Ala Leu Ile Tyr Ser Leu Phe Pro 
                405                 410                 415     


Asn Val Pro Pro Thr Ile Tyr Phe Gly Thr Arg Asp Glu Arg Val Glu 
            420                 425                 430         


Lys Leu Pro Trp Glu Gln Arg Lys Leu Leu Arg Trp Lys Met Ser Thr 
        435                 440                 445             


Val Thr Pro Asn Ile Val Lys Gln Thr Ile Gly Arg Ser His Phe Lys 
    450                 455                 460                 


Ile Ser Lys Arg Asn Asp Asp Trp Leu Gly Cys Trp Gly His His Met 
465                 470                 475                 480 


Lys Ser Pro Ser Phe Arg Ser Ile Arg Glu His Gln Lys Leu Asn His 
                485                 490                 495     


Phe Pro Gly Ser Phe Gln Ile Gly Arg Lys Asp Arg Leu Trp Arg Asn 
            500                 505                 510         


Leu Ser Arg Met Gln Ser Arg Phe Gly Lys Lys Glu Phe Ser Phe Phe 
        515                 520                 525             


Pro Gln Ser Phe Ile Leu Pro Gln Asp Ala Lys Leu Leu Arg Lys Ala 
    530                 535                 540                 


Trp Glu Ser Ser Ser Arg Gln Lys Trp Ile Val Lys Pro Pro Ala Ser 
545                 550                 555                 560 


Ala Arg Gly Ile Gly Ile Gln Val Ile His Lys Trp Ser Gln Leu Pro 
                565                 570                 575     


Lys Arg Arg Pro Leu Leu Val Gln Arg Tyr Leu His Lys Pro Tyr Leu 
            580                 585                 590         


Ile Ser Gly Ser Lys Phe Asp Leu Arg Ile Tyr Val Tyr Val Thr Ser 
        595                 600                 605             


Tyr Asp Pro Leu Arg Ile Tyr Leu Phe Ser Asp Gly Leu Val Arg Phe 
    610                 615                 620                 


Ala Ser Cys Lys Tyr Ser Pro Ser Met Lys Ser Leu Gly Asn Lys Phe 
625                 630                 635                 640 


Met His Leu Thr Asn Tyr Ser Val Asn Lys Lys Asn Ala Glu Tyr Gln 
                645                 650                 655     


Ala Asn Ala Asp Glu Met Ala Cys Gln Gly His Lys Trp Ala Leu Lys 
            660                 665                 670         


Ala Leu Trp Asn Tyr Leu Ser Gln Lys Gly Val Asn Ser Asp Ala Ile 
        675                 680                 685             


Trp Glu Lys Ile Lys Asp Val Val Val Lys Thr Ile Ile Ser Ser Glu 
    690                 695                 700                 


Pro Tyr Val Thr Ser Leu Leu Lys Met Tyr Val Arg Arg Pro Tyr Ser 
705                 710                 715                 720 


Cys His Glu Leu Phe Gly Phe Asp Ile Met Leu Asp Glu Asn Leu Lys 
                725                 730                 735     


Pro Trp Val Leu Glu Val Asn Ile Ser Pro Ser Leu His Ser Ser Ser 
            740                 745                 750         


Pro Leu Asp Ile Ser Ile Lys Gly Gln Met Ile Arg Asp Leu Leu Asn 
        755                 760                 765             


Leu Ala Gly Phe Val Leu Pro Asn Ala Glu Asp Ile Ile Ser Ser Pro 
    770                 775                 780                 


Ser Ser Cys Ser Ser Ser Thr Thr Ser Leu Pro Thr Ser Pro Gly Asp 
785                 790                 795                 800 


Lys Cys Arg Met Ala Pro Glu His Val Thr Ala Gln Lys Met Lys Lys 
                805                 810                 815     


Ala Tyr Tyr Leu Thr Gln Lys Ile Pro Asp Gln Asp Phe Tyr Ala Ser 
            820                 825                 830         


Val Leu Asp Val Leu Thr Pro Asp Asp Val Arg Ile Leu Val Glu Met 
        835                 840                 845             


Glu Asp Glu Phe Ser Arg Arg Gly Gln Phe Glu Arg Ile Phe Pro Ser 
    850                 855                 860                 


His Ile Ser Ser Arg Tyr Leu Arg Phe Phe Glu Gln Pro Arg Tyr Phe 
865                 870                 875                 880 


Asn Ile Leu Thr Thr Gln Trp Glu Gln Lys Tyr His Gly Asn Lys Leu 
                885                 890                 895     


Lys Gly Val Asp Leu Leu Arg Ser Trp Cys Tyr Lys Gly Phe His Met 
            900                 905                 910         


Gly Val Val Ser Asp Ser Ala Pro Val Trp Ser Leu Pro Thr Ser Leu 
        915                 920                 925             


Leu Thr Ile Ser Lys Asp Asp Val Ile Leu Asn Ala Phe Ser Lys Ser 
    930                 935                 940                 


Glu Thr Ser Lys Leu Gly Asn Pro Val Pro Gln Arg Thr Val Arg Thr 
945                 950                 955                 960 


Pro Ala Lys Ser Pro Ala Phe Leu Pro Arg Arg Tyr Leu 
                965                 970             


<210>  19
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly Lys Leu Arg Pro Trp Arg Asp Leu Leu Glu Pro Val Ser Cys 
1               5                   10                  15      


Asp Leu Ser Asp Asp Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys 
            20                  25                  30          


Val Pro Arg Arg Cys Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp 
        35                  40                  45              


Val Asp Tyr Phe Ser Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu 
    50                  55                  60                  


Thr Val Thr Leu Thr Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu 
65                  70                  75                  80  


Gln Ile Ser Thr Asp Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala 
                85                  90                  95      


Leu Gly Ser Pro Gln Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe 
            100                 105                 110         


Glu Val Val Tyr Lys Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile 
        115                 120                 125             


Leu Leu Ser Asn Thr Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met 
    130                 135                 140                 


Pro Ser Ser Thr Tyr Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly 
145                 150                 155                 160 


Ser Arg Leu Ser Gly Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp 
                165                 170                 175     


Asp Ser Gln Pro Gly Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe 
            180                 185                 190         


Phe Asp Gly Ala Ala Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu 
        195                 200                 205             


Val Ala Ser Ser Val Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp 
    210                 215                 220                 


Ala Gly Ser Ala Val Leu Leu Arg Glu Glu Glu Cys Ser Pro Val Leu 
225                 230                 235                 240 


Arg Glu Gly Leu Gly Ser Leu His Thr Arg His His Cys Gln Ile Pro 
                245                 250                 255     


Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile Val Ser Val Gln Pro 
            260                 265                 270         


Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val Asn Ile Gln Met Ala 
        275                 280                 285             


Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp Ser Tyr Ser Leu Arg 
    290                 295                 300                 


Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile Asp His Thr Phe Glu 
305                 310                 315                 320 


Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys Asp Ser Lys Thr Glu 
                325                 330                 335     


Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro Ala Leu Glu Pro Ser 
            340                 345                 350         


Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr Ser Arg Thr Gly Tyr 
        355                 360                 365             


Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg Ser Trp Asp Thr Glu 
    370                 375                 380                 


Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile Val Ile Phe Leu Thr 
385                 390                 395                 400 


Ile Ala Val Leu Leu Ala Leu Arg Phe Cys Gly Ile Tyr Gly Tyr Arg 
                405                 410                 415     


Leu Arg Arg Lys Trp Glu Glu Lys Ile Pro Asn Pro Ser Lys Ser His 
            420                 425                 430         


Leu Phe Gln Asn Gly Ser Ala Glu Leu Trp Pro Pro Gly Ser Met Ser 
        435                 440                 445             


Ala Phe Thr Ser Gly Ser Pro Pro His Gln Gly Pro Trp Gly Ser Arg 
    450                 455                 460                 


Phe Pro Glu Leu Glu Gly Val Phe Pro Val Gly Phe Gly Asp Ser Glu 
465                 470                 475                 480 


Val Ser Pro Leu Thr Ile Glu Asp Pro Lys His Val Cys Asp Pro Pro 
                485                 490                 495     


Ser Gly Pro Asp Thr Thr Pro Ala Ala Ser Asp Leu Pro Thr Glu Gln 
            500                 505                 510         


Pro Pro Ser Pro Gln Pro Gly Pro Pro Ala Ala Ser His Thr Pro Glu 
        515                 520                 525             


Lys Gln Ala Ser Ser Phe Asp Phe Asn Gly Pro Tyr Leu Gly Pro Pro 
    530                 535                 540                 


His Ser Arg Ser Leu Pro Asp Ile Leu Gly Gln Pro Glu Pro Pro Gln 
545                 550                 555                 560 


Glu Gly Gly Ser Gln Lys Ser Pro Pro Pro Gly Ser Leu Glu Tyr Leu 
                565                 570                 575     


Cys Leu Pro Ala Gly Gly Gln Val Gln Leu Val Pro Leu Ala Gln Ala 
            580                 585                 590         


Met Gly Pro Gly Gln Ala Val Glu Val Glu Arg Arg Pro Ser Gln Gly 
        595                 600                 605             


Ala Ala Gly Ser Pro Ser Leu Glu Ser Gly Gly Gly Pro Ala Pro Pro 
    610                 615                 620                 


Ala Leu Gly Pro Arg Val Gly Gly Gln Asp Gln Lys Asp Ser Pro Val 
625                 630                 635                 640 


Ala Ile Pro Met Ser Ser Gly Asp Thr Glu Asp Pro Gly Val Ala Ser 
                645                 650                 655     


Gly Tyr Val Ser Ser Ala Asp Leu Val Phe Thr Pro Asn Ser Gly Ala 
            660                 665                 670         


Ser Ser Val Ser Leu Val Pro Ser Leu Gly Leu Pro Ser Asp Gln Thr 
        675                 680                 685             


Pro Ser Leu Cys Pro Gly Leu Ala Ser Gly Pro Pro Gly Ala Pro Gly 
    690                 695                 700                 


Pro Val Lys Ser Gly Phe Glu Gly Tyr Val Glu Leu Pro Pro Ile Glu 
705                 710                 715                 720 


Gly Arg Ser Pro Arg Ser Pro Arg Asn Asn Pro Val Pro Pro Glu Ala 
                725                 730                 735     


Lys Ser Pro Val Leu Asn Pro Gly Glu Arg Pro Ala Asp Val Ser Pro 
            740                 745                 750         


Thr Ser Pro Gln Pro Glu Gly Leu Leu Val Leu Gln Gln Val Gly Asp 
        755                 760                 765             


Tyr Cys Phe Leu Pro Gly Leu Gly Pro Gly Pro Leu Ser Leu Arg Ser 
    770                 775                 780                 


Lys Pro Ser Ser Pro Gly Pro Gly Pro Glu Ile Lys Asn Leu Asp Gln 
785                 790                 795                 800 


Ala Phe Gln Val Lys Lys Pro Pro Gly Gln Ala Val Pro Gln Val Pro 
                805                 810                 815     


Val Ile Gln Leu Phe Lys Ala Leu Lys Gln Gln Asp Tyr Leu Ser Leu 
            820                 825                 830         


Pro Pro Trp Glu Val Asn Lys Pro Gly Glu Val Cys 
        835                 840                 


<210>  20
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Ala Arg Leu Leu Arg Gly Ser Leu Arg Val Leu Gly Gly His 
1               5                   10                  15      


Arg Ala Pro Arg Gln Leu Pro Ala Ala Arg Cys Ser His Ser Gly Gly 
            20                  25                  30          


Glu Glu Arg Leu Glu Thr Pro Ser Ala Lys Lys Leu Thr Asp Ile Gly 
        35                  40                  45              


Ile Arg Arg Ile Phe Ser Pro Glu His Asp Ile Phe Arg Lys Ser Val 
    50                  55                  60                  


Arg Lys Phe Phe Gln Glu Glu Val Ile Pro His His Ser Glu Trp Glu 
65                  70                  75                  80  


Lys Ala Gly Glu Val Ser Arg Glu Val Trp Glu Lys Ala Gly Lys Gln 
                85                  90                  95      


Gly Leu Leu Gly Val Asn Ile Ala Glu His Leu Gly Gly Ile Gly Gly 
            100                 105                 110         


Asp Leu Tyr Ser Ala Ala Ile Val Trp Glu Glu Gln 
        115                 120                 


<210>  21
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gln Ser Glu Ile Ala Met Asp Arg Met Lys Lys Ile Lys Arg Gln 
1               5                   10                  15      


Leu Ser Met Thr Leu Arg Gly Gly Arg Gly Ile Asp Lys Thr Asn Gly 
            20                  25                  30          


Ala Pro Glu Gln Ile Gly Leu Asp Glu Ser Gly Gly Gly Gly Gly Ser 
        35                  40                  45              


Asp Pro Gly Glu Ala Pro Thr Arg Ala Ala Pro Gly Glu Leu Arg Ser 
    50                  55                  60                  


Ala Arg Gly Pro Leu Ser Ser Ala Pro Glu Ile Val His Glu Asp Leu 
65                  70                  75                  80  


Lys Met Gly Ser Asp Gly Glu Ser Asp Gln Ala Ser Ala Thr Ser Ser 
                85                  90                  95      


Asp Glu Val Gln Ser Pro Val Arg Val Arg Met Arg Asn His Pro Pro 
            100                 105                 110         


Arg Lys Ile Ser Thr Glu Asp Ile Asn Lys Arg Leu Ser Leu Pro Ala 
        115                 120                 125             


Asp Ile Arg Leu Pro Glu Gly Tyr Leu Glu Lys Leu Thr Leu Asn Ser 
    130                 135                 140                 


Pro Ile Phe Asp Lys Pro Leu Ser Arg Arg Leu Arg Arg Val Ser Leu 
145                 150                 155                 160 


Ser Glu Ile Gly Phe Gly Lys Leu Glu Thr Tyr Ile Lys Leu Asp Lys 
                165                 170                 175     


Leu Gly Glu Gly Thr Tyr Ala Thr Val Tyr Lys Gly Lys Ser Lys Leu 
            180                 185                 190         


Thr Asp Asn Leu Val Ala Leu Lys Glu Ile Arg Leu Glu His Glu Glu 
        195                 200                 205             


Gly Ala Pro Cys Thr Ala Ile Arg Glu Val Ser Leu Leu Lys Asp Leu 
    210                 215                 220                 


Lys His Ala Asn Ile Val Thr Leu His Asp Ile Ile His Thr Glu Lys 
225                 230                 235                 240 


Ser Leu Thr Leu Val Phe Glu Tyr Leu Asp Lys Asp Leu Lys Gln Tyr 
                245                 250                 255     


Leu Asp Asp Cys Gly Asn Ile Ile Asn Met His Asn Val Lys Leu Phe 
            260                 265                 270         


Leu Phe Gln Leu Leu Arg Gly Leu Ala Tyr Cys His Arg Gln Lys Val 
        275                 280                 285             


Leu His Arg Asp Leu Lys Pro Gln Asn Leu Leu Ile Asn Glu Arg Gly 
    290                 295                 300                 


Glu Leu Lys Leu Ala Asp Phe Gly Leu Ala Arg Ala Lys Ser Ile Pro 
305                 310                 315                 320 


Thr Lys Thr Tyr Ser Asn Glu Val Val Thr Leu Trp Tyr Arg Pro Pro 
                325                 330                 335     


Asp Ile Leu Leu Gly Ser Thr Asp Tyr Ser Thr Gln Ile Asp Met Trp 
            340                 345                 350         


Gly Val Gly Cys Ile Phe Tyr Glu Met Ala Thr Gly Arg Pro Leu Phe 
        355                 360                 365             


Pro Gly Ser Thr Val Glu Glu Gln Leu His Phe Ile Phe Arg Ile Leu 
    370                 375                 380                 


Gly Thr Pro Thr Glu Glu Thr Trp Pro Gly Ile Leu Ser Asn Glu Glu 
385                 390                 395                 400 


Phe Lys Thr Tyr Asn Tyr Pro Lys Tyr Arg Ala Glu Ala Leu Leu Ser 
                405                 410                 415     


His Ala Pro Arg Leu Asp Ser Asp Gly Ala Asp Leu Leu Thr Lys Leu 
            420                 425                 430         


Leu Gln Phe Glu Gly Arg Asn Arg Ile Ser Ala Glu Asp Ala Met Lys 
        435                 440                 445             


His Pro Phe Phe Leu Ser Leu Gly Glu Arg Ile His Lys Leu Pro Asp 
    450                 455                 460                 


Thr Thr Ser Ile Phe Ala Leu Lys Glu Ile Gln Leu Gln Lys Glu Ala 
465                 470                 475                 480 


Ser Leu Arg Ser Ser Ser Met Pro Asp Ser Gly Arg Pro Ala Phe Arg 
                485                 490                 495     


Val Val Asp Thr Glu Phe 
            500         


<210>  22
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Gly Phe 
1               5                   10                  15      


Leu Met Val Leu Asp Ile Pro Gln Glu Arg Gly Leu Ser Ser Leu Asp 
            20                  25                  30          


Arg Lys Tyr Leu Asp Gly Leu Asp Val Cys Arg Phe Pro Leu Leu Asp 
        35                  40                  45              


Ala Leu Arg Pro Leu Pro Leu Asp Trp Met Tyr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Met Phe Leu Gly Ala Leu Gly Met Met Leu Gly Leu Cys Tyr Arg Ile 
65                  70                  75                  80  


Ser Cys Val Leu Phe Leu Leu Pro Tyr Trp Tyr Val Phe Leu Leu Asp 
                85                  90                  95      


Lys Thr Ser Trp Asn Asn His Ser Tyr Leu Tyr Gly Leu Leu Ala Phe 
            100                 105                 110         


Gln Leu Thr Phe Met Asp Ala Asn His Tyr Trp Ser Val Asp Gly Leu 
        115                 120                 125             


Leu Asn Ala His Arg Arg Asn Ala His Val Pro Leu Trp Asn Tyr Ala 
    130                 135                 140                 


Val Leu Arg Gly Gln Ile Phe Ile Val Tyr Phe Ile Ala Gly Val Lys 
145                 150                 155                 160 


Lys Leu Asp Ala Asp Trp Val Glu Gly Tyr Ser Met Glu Tyr Leu Ser 
                165                 170                 175     


Arg His Trp Leu Phe Ser Pro Phe Lys Leu Leu Leu Ser Glu Glu Leu 
            180                 185                 190         


Thr Ser Leu Leu Val Val His Trp Gly Gly Leu Leu Leu Asp Leu Ser 
        195                 200                 205             


Ala Gly Phe Leu Leu Phe Phe Asp Val Ser Arg Ser Ile Gly Leu Phe 
    210                 215                 220                 


Phe Val Ser Tyr Phe His Cys Met Asn Ser Gln Leu Phe Ser Ile Gly 
225                 230                 235                 240 


Met Phe Ser Tyr Val Met Leu Ala Ser Ser Pro Leu Phe Cys Ser Pro 
                245                 250                 255     


Glu Trp Pro Arg Lys Leu Val Ser Tyr Cys Pro Arg Arg Leu Gln Gln 
            260                 265                 270         


Leu Leu Pro Leu Lys Ala Ala Pro Gln Pro Ser Val Ser Cys Val Tyr 
        275                 280                 285             


Lys Arg Ser Arg Gly Lys Ser Gly Gln Lys Pro Gly Leu Arg His Gln 
    290                 295                 300                 


Leu Gly Ala Ala Phe Thr Leu Leu Tyr Leu Leu Glu Gln Leu Phe Leu 
305                 310                 315                 320 


Pro Tyr Ser His Phe Leu Thr Gln Gly Tyr Asn Asn Trp Thr Asn Gly 
                325                 330                 335     


Leu Tyr Gly Tyr Ser Trp Asp Met Met Val His Ser Arg Ser His Gln 
            340                 345                 350         


His Val Lys Ile Thr Tyr Arg Asp Gly Arg Thr Gly Glu Leu Gly Tyr 
        355                 360                 365             


Leu Asn Pro Gly Val Phe Thr Gln Ser Arg Arg Trp Lys Asp His Ala 
    370                 375                 380                 


Asp Met Leu Lys Gln Tyr Ala Thr Cys Leu Ser Arg Leu Leu Pro Lys 
385                 390                 395                 400 


Tyr Asn Val Thr Glu Pro Gln Ile Tyr Phe Asp Ile Trp Val Ser Ile 
                405                 410                 415     


Asn Asp Arg Phe Gln Gln Arg Ile Phe Asp Pro Arg Val Asp Ile Val 
            420                 425                 430         


Gln Ala Ala Trp Ser Pro Phe Gln Arg Thr Ser Trp Val Gln Pro Leu 
        435                 440                 445             


Leu Met Asp Leu Ser Pro Trp Arg Ala Lys Leu Gln Glu Ile Lys Ser 
    450                 455                 460                 


Ser Leu Asp Asn His Thr Glu Val Val Phe Ile Ala Asp Phe Pro Gly 
465                 470                 475                 480 


Leu His Leu Glu Asn Phe Val Ser Glu Asp Leu Gly Asn Thr Ser Ile 
                485                 490                 495     


Gln Leu Leu Gln Gly Glu Val Thr Val Glu Leu Val Ala Glu Gln Lys 
            500                 505                 510         


Asn Gln Thr Leu Arg Glu Gly Glu Lys Met Gln Leu Pro Ala Gly Glu 
        515                 520                 525             


Tyr His Lys Val Tyr Thr Thr Ser Pro Ser Pro Ser Cys Tyr Met Tyr 
    530                 535                 540                 


Val Tyr Val Asn Thr Thr Glu Leu Ala Leu Glu Gln Asp Leu Ala Tyr 
545                 550                 555                 560 


Leu Gln Glu Leu Lys Glu Lys Val Glu Asn Gly Ser Glu Thr Gly Pro 
                565                 570                 575     


Leu Pro Pro Glu Leu Gln Pro Leu Leu Glu Gly Glu Val Lys Gly Gly 
            580                 585                 590         


Pro Glu Pro Thr Pro Leu Val Gln Thr Phe Leu Arg Arg Gln Gln Arg 
        595                 600                 605             


Leu Gln Glu Ile Glu Arg Arg Arg Asn Thr Pro Phe His Glu Arg Phe 
    610                 615                 620                 


Phe Arg Phe Leu Leu Arg Lys Leu Tyr Val Phe Arg Arg Ser Phe Leu 
625                 630                 635                 640 


Met Thr Cys Ile Ser Leu Arg Asn Leu Ile Leu Gly Arg Pro Ser Leu 
                645                 650                 655     


Glu Gln Leu Ala Gln Glu Val Thr Tyr Ala Asn Leu Arg Pro Phe Glu 
            660                 665                 670         


Ala Val Gly Glu Leu Asn Pro Ser Asn Thr Asp Ser Ser His Ser Asn 
        675                 680                 685             


Pro Pro Glu Ser Asn Pro Asp Pro Val His Ser Glu Phe 
    690                 695                 700     


<210>  23
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly Pro Ala Pro Ala Gly Glu Gln Leu Arg Gly Ala Thr Gly Glu 
1               5                   10                  15      


Pro Glu Val Met Glu Pro Ala Leu Glu Gly Thr Gly Lys Glu Gly Lys 
            20                  25                  30          


Lys Ala Ser Ser Arg Lys Arg Thr Leu Ala Glu Pro Pro Ala Lys Gly 
        35                  40                  45              


Leu Leu Gln Pro Val Lys Leu Ser Arg Ala Glu Leu Tyr Lys Glu Pro 
    50                  55                  60                  


Thr Asn Glu Glu Leu Asn Arg Leu Arg Glu Thr Glu Ile Leu Phe His 
65                  70                  75                  80  


Ser Ser Leu Leu Arg Leu Gln Val Glu Glu Leu Leu Lys Glu Val Arg 
                85                  90                  95      


Leu Ser Glu Lys Lys Lys Asp Arg Ile Asp Ala Phe Leu Arg Glu Val 
            100                 105                 110         


Asn Gln Arg Val Val Arg Val Pro Ser Val Pro Glu Thr Glu Leu Thr 
        115                 120                 125             


Asp Gln Ala Trp Leu Pro Ala Gly Val Arg Val Pro Leu His Gln Val 
    130                 135                 140                 


Pro Tyr Ala Val Lys Gly Cys Phe Arg Phe Leu Pro Pro Ala Gln Val 
145                 150                 155                 160 


Thr Val Val Gly Ser Tyr Leu Leu Gly Thr Cys Ile Arg Pro Asp Ile 
                165                 170                 175     


Asn Val Asp Val Ala Leu Thr Met Pro Arg Glu Ile Leu Gln Asp Lys 
            180                 185                 190         


Asp Gly Leu Asn Gln Arg Tyr Phe Arg Lys Arg Ala Leu Tyr Leu Ala 
        195                 200                 205             


His Leu Ala His His Leu Ala Gln Asp Pro Leu Phe Gly Ser Val Cys 
    210                 215                 220                 


Phe Ser Tyr Thr Asn Gly Cys His Leu Lys Pro Ser Leu Leu Leu Arg 
225                 230                 235                 240 


Pro Arg Gly Lys Asp Glu Arg Leu Val Thr Val Arg Leu His Pro Cys 
                245                 250                 255     


Pro Pro Pro Asp Phe Phe Arg Pro Cys Arg Leu Leu Pro Thr Lys Asn 
            260                 265                 270         


Asn Val Arg Ser Ala Trp Tyr Arg Gly Gln Ser Pro Ala Gly Asp Gly 
        275                 280                 285             


Ser Pro Glu Pro Pro Thr Pro Arg Tyr Asn Thr Trp Val Leu Gln Asp 
    290                 295                 300                 


Thr Val Leu Glu Ser His Leu Gln Leu Leu Ser Thr Ile Leu Ser Ser 
305                 310                 315                 320 


Ala Gln Gly Leu Lys Asp Gly Val Ala Leu Leu Lys Val Trp Leu Arg 
                325                 330                 335     


Gln Arg Glu Leu Asp Lys Gly Gln Gly Gly Phe Thr Gly Phe Leu Val 
            340                 345                 350         


Ser Met Leu Val Val Phe Leu Val Ser Thr Arg Lys Ile His Thr Thr 
        355                 360                 365             


Met Ser Gly Tyr Gln Val Leu Arg Ser Val Leu Gln Phe Leu Ala Thr 
    370                 375                 380                 


Thr Asp Leu Thr Val Asn Gly Ile Ser Leu Cys Leu Ser Ser Asp Pro 
385                 390                 395                 400 


Ser Leu Pro Ala Leu Ala Asp Phe His Gln Ala Phe Ser Val Val Phe 
                405                 410                 415     


Leu Asp Ser Ser Gly His Leu Asn Leu Cys Ala Asp Val Thr Ala Ser 
            420                 425                 430         


Thr Tyr His Gln Val Gln His Glu Ala Arg Leu Ser Met Met Leu Leu 
        435                 440                 445             


Asp Ser Arg Ala Asp Asp Gly Phe His Leu Leu Leu Met Thr Pro Lys 
    450                 455                 460                 


Pro Met Ile Arg Ala Phe Asp His Val Leu His Leu Arg Pro Leu Ser 
465                 470                 475                 480 


Arg Leu Gln Ala Ala Cys His Arg Leu Lys Leu Trp Pro Glu Leu Gln 
                485                 490                 495     


Asp Asn Gly Gly Asp Tyr Val Ser Ala Ala Leu Gly Pro Leu Thr Thr 
            500                 505                 510         


Leu Leu Glu Gln Gly Leu Gly Ala Arg Leu Asn Leu Leu Ala His Ser 
        515                 520                 525             


Arg Pro Pro Val Pro Glu Trp Asp Ile Ser Gln Asp Pro Pro Lys His 
    530                 535                 540                 


Lys Asp Ser Gly Thr Leu Thr Leu Gly Leu Leu Leu Arg Pro Glu Gly 
545                 550                 555                 560 


Leu Thr Ser Val Leu Glu Leu Gly Pro Glu Ala Asp Gln Pro Glu Ala 
                565                 570                 575     


Ala Lys Phe Arg Gln Phe Trp Gly Ser Arg Ser Glu Leu Arg Arg Phe 
            580                 585                 590         


Gln Asp Gly Ala Ile Arg Glu Ala Val Val Trp Glu Ala Ala Ser Met 
        595                 600                 605             


Ser Gln Lys Arg Leu Ile Pro His Gln Val Val Thr His Leu Leu Ala 
    610                 615                 620                 


Leu His Ala Asp Ile Pro Glu Thr Cys Val His Tyr Val Gly Gly Pro 
625                 630                 635                 640 


Leu Asp Ala Leu Ile Gln Gly Leu Lys Glu Ala Ser Ser Thr Lys Gly 
                645                 650                 655     


Arg Met Val Met Ser Arg Gly Gly Glu Leu Val Met Val Pro Asn Val 
            660                 665                 670         


Glu Ala Ile Leu Glu Asp Phe Ala Val Leu Gly Glu Gly Leu Val Gln 
        675                 680                 685             


Thr Val Glu Ala Arg Ser Glu Arg Trp Thr Val 
    690                 695                 


<210>  24
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val 
            20                  25                  30          


Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser 
        35                  40                  45              


Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp 
    50                  55                  60                  


Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser 
65                  70                  75                  80  


Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val 
                85                  90                  95      


Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu 
            100                 105                 110         


Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His 
        115                 120                 125             


Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val 
    130                 135                 140                 


Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val 
                165                 170                 175     


His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr 
            180                 185                 190         


Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu 
        195                 200                 205             


Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser 
    210                 215                 220                 


Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala 
225                 230                 235                 240 


Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val 
                245                 250                 255     


Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala 
            260                 265                 270         


Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu 
        275                 280                 285             


Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Arg Gln 
    290                 295                 300                 


Leu Pro Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu 
305                 310                 315                 320 


Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly 
                325                 330                 335     


Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala 
            340                 345                 350         


Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly 
        355                 360                 365             


Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val 
    370                 375                 380                 


Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp 
385                 390                 395                 400 


Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly 
                405                 410                 415     


Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val 
            420                 425                 430         


His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala 
        435                 440                 445             


Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile 
    450                 455                 460                 


Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Ser Ala Arg Ser Gly Pro 
465                 470                 475                 480 


Val Thr Val Tyr Pro Tyr Met His Ala Leu Asp Thr Leu Phe Val Pro 
                485                 490                 495     


Leu Leu Val Gly Thr Gly Val Ala Leu Val Thr Gly Ala Thr Val Leu 
            500                 505                 510         


Gly Thr Ile Thr Cys Cys Phe Met Lys Arg Leu Arg Lys Arg 
        515                 520                 525     


<210>  25
<211>  1006
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu Asn His Thr Pro Asn Ser 
1               5                   10                  15      


Ser Thr Lys Thr His Leu Gly Thr Gly Met Glu Arg Ser Pro Gly Ala 
            20                  25                  30          


Met Glu Arg Val Leu Lys Val Phe His Tyr Phe Glu Ser Asn Ser Glu 
        35                  40                  45              


Pro Thr Thr Trp Ala Ser Ile Ile Arg His Gly Asp Ala Thr Asp Val 
    50                  55                  60                  


Arg Gly Ile Ile Gln Lys Ile Val Asp Ser His Lys Val Lys His Val 
65                  70                  75                  80  


Ala Cys Tyr Gly Phe Arg Leu Ser His Leu Arg Ser Glu Glu Val His 
                85                  90                  95      


Trp Leu His Val Asp Met Gly Val Ser Ser Val Arg Glu Lys Tyr Glu 
            100                 105                 110         


Leu Ala His Pro Pro Glu Glu Trp Lys Tyr Glu Leu Arg Ile Arg Tyr 
        115                 120                 125             


Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr Glu Asp Lys Pro Thr Leu 
    130                 135                 140                 


Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp Tyr Met Leu Glu Ile Ala 
145                 150                 155                 160 


Asp Gln Val Asp Gln Glu Ile Ala Leu Lys Leu Gly Cys Leu Glu Ile 
                165                 170                 175     


Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn Ala Leu Glu Lys Lys Ser 
            180                 185                 190         


Asn Tyr Glu Val Leu Glu Lys Asp Val Gly Leu Lys Arg Phe Phe Pro 
        195                 200                 205             


Lys Ser Leu Leu Asp Ser Val Lys Ala Lys Thr Leu Arg Lys Leu Ile 
    210                 215                 220                 


Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu Asn Arg Glu Glu Ser Ile 
225                 230                 235                 240 


Leu Lys Phe Phe Glu Ile Leu Ser Pro Val Tyr Arg Phe Asp Lys Glu 
                245                 250                 255     


Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp Ile Ile Ser Val Glu Leu 
            260                 265                 270         


Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr Leu Thr Asp Lys Gly Cys 
        275                 280                 285             


Asn Pro Thr His Leu Ala Asp Phe Thr Gln Val Gln Thr Ile Gln Tyr 
    290                 295                 300                 


Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly Met Leu Gln Leu Lys Ile 
305                 310                 315                 320 


Ala Gly Ala Pro Glu Pro Leu Thr Val Thr Ala Pro Ser Leu Thr Ile 
                325                 330                 335     


Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys Arg Leu Val Asn 
            340                 345                 350         


Gly Thr Ser Gln Ser Phe Ile Ile Arg Pro Gln Lys Glu Gly Glu Arg 
        355                 360                 365             


Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn Ser Glu Lys Gln Gly Met 
    370                 375                 380                 


Arg Thr His Ala Val Ser Val Ser Glu Thr Asp Asp Tyr Ala Glu Ile 
385                 390                 395                 400 


Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro Ser Thr Arg Asp Tyr Glu 
                405                 410                 415     


Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg Cys Ile Gly Glu Gly Gln 
            420                 425                 430         


Phe Gly Asp Val His Gln Gly Ile Tyr Met Ser Pro Glu Asn Pro Ala 
        435                 440                 445             


Leu Ala Val Ala Ile Lys Thr Cys Lys Asn Cys Thr Ser Asp Ser Val 
    450                 455                 460                 


Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr Met Arg Gln Phe Asp His 
465                 470                 475                 480 


Pro His Ile Val Lys Leu Ile Gly Val Ile Thr Glu Asn Pro Val Trp 
                485                 490                 495     


Ile Ile Met Glu Leu Cys Thr Leu Gly Glu Leu Arg Ser Phe Leu Gln 
            500                 505                 510         


Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser Leu Ile Leu Tyr Ala Tyr 
        515                 520                 525             


Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu Ser Lys Arg Phe Val His 
    530                 535                 540                 


Arg Asp Ile Ala Ala Arg Asn Val Leu Val Ser Ser Asn Asp Cys Val 
545                 550                 555                 560 


Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Met Glu Asp Ser Thr Tyr 
                565                 570                 575     


Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile Lys Trp Met Ala Pro Glu 
            580                 585                 590         


Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala Ser Asp Val Trp Met Phe 
        595                 600                 605             


Gly Val Cys Met Trp Glu Ile Leu Met His Gly Val Lys Pro Phe Gln 
    610                 615                 620                 


Gly Val Lys Asn Asn Asp Val Ile Gly Arg Ile Glu Asn Gly Glu Arg 
625                 630                 635                 640 


Leu Pro Met Pro Pro Asn Cys Pro Pro Thr Leu Tyr Ser Leu Met Thr 
                645                 650                 655     


Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg Pro Arg Phe Thr Glu Leu 
            660                 665                 670         


Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu Glu Lys Ala Gln Gln Glu 
        675                 680                 685             


Glu Arg Met Arg Met Glu Ser Arg Arg Gln Ala Thr Val Ser Trp Asp 
    690                 695                 700                 


Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys Pro Ser Arg Pro Gly Tyr 
705                 710                 715                 720 


Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr Pro Ser Pro Gln His Met 
                725                 730                 735     


Val Gln Thr Asn His Tyr Gln Asp Ser Thr Val Leu Asp Leu Arg Gly 
            740                 745                 750         


Ile Gly Gln Val Leu Pro Thr His Leu Met Glu Glu Arg Leu Ile Arg 
        755                 760                 765             


Gln Gln Gln Glu Met Glu Glu Asp Gln Arg Trp Leu Glu Lys Glu Glu 
    770                 775                 780                 


Arg Phe Leu Lys Pro Asp Val Arg Leu Ser Arg Gly Ser Ile Asp Arg 
785                 790                 795                 800 


Glu Asp Gly Ser Leu Gln Gly Pro Ile Gly Asn Gln His Ile Tyr Gln 
                805                 810                 815     


Pro Val Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys Lys Pro Pro Arg 
            820                 825                 830         


Pro Gly Ala Pro Gly His Leu Gly Ser Leu Ala Ser Leu Ser Ser Pro 
        835                 840                 845             


Ala Asp Ser Tyr Asn Glu Gly Val Lys Leu Gln Pro Gln Glu Ile Ser 
    850                 855                 860                 


Pro Pro Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp Lys Val Tyr Glu 
865                 870                 875                 880 


Asn Val Thr Gly Leu Val Lys Ala Val Ile Glu Met Ser Ser Lys Ile 
                885                 890                 895     


Gln Pro Ala Pro Pro Glu Glu Tyr Val Pro Met Val Lys Glu Val Gly 
            900                 905                 910         


Leu Ala Leu Arg Thr Leu Leu Ala Thr Val Asp Glu Thr Ile Pro Leu 
        915                 920                 925             


Leu Pro Ala Ser Thr His Arg Glu Ile Glu Met Ala Gln Lys Leu Leu 
    930                 935                 940                 


Asn Ser Asp Leu Gly Glu Leu Ile Asn Lys Met Lys Leu Ala Gln Gln 
945                 950                 955                 960 


Tyr Val Met Thr Ser Leu Gln Gln Glu Tyr Lys Lys Gln Met Leu Thr 
                965                 970                 975     


Ala Ala His Ala Leu Ala Val Asp Ala Lys Asn Leu Leu Asp Val Ile 
            980                 985                 990         


Asp Gln Ala Arg Leu Lys Met Leu  Gly Gln Thr Arg Pro  His 
        995                 1000                 1005     


<210>  26
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Trp Gly His His Leu Pro Arg Ala Ser Trp Gly Ser Gly Phe 
1               5                   10                  15      


Arg Arg Ala Leu Gln Arg Pro Asp Asp Arg Ile Pro Phe Leu Ile His 
            20                  25                  30          


Trp Ser Trp Pro Leu Gln Gly Glu Arg Pro Phe Gly Pro Pro Arg Ala 
        35                  40                  45              


Phe Ile Arg His His Gly Ser Ser Val Asp Ser Ala Pro Pro Pro Gly 
    50                  55                  60                  


Arg His Gly Arg Leu Phe Pro Ser Ala Ser Ala Thr Glu Ala Ile Gln 
65                  70                  75                  80  


Arg His Arg Arg Asn Leu Ala Glu Trp Phe Ser Arg Leu Pro Arg Glu 
                85                  90                  95      


Glu Arg Gln Phe Gly Pro Thr Phe Ala Leu Asp Thr Val His Val Asp 
            100                 105                 110         


Pro Val Ile Arg Glu Ser Thr Pro Asp Glu Leu Leu Arg Pro Pro Ala 
        115                 120                 125             


Glu Leu Ala Leu Glu His Gln Pro Pro Gln Ala Gly Leu Pro Pro Leu 
    130                 135                 140                 


Ala Leu Ser Gln Leu Phe Asn Pro Asp Ala Cys Gly Arg Arg Val Gln 
145                 150                 155                 160 


Thr Val Val Leu Tyr Gly Thr Val Gly Thr Gly Lys Ser Thr Leu Val 
                165                 170                 175     


Arg Lys Met Val Leu Asp Trp Cys Tyr Gly Arg Leu Pro Ala Phe Glu 
            180                 185                 190         


Leu Leu Ile Pro Phe Ser Cys Glu Asp Leu Ser Ser Leu Gly Pro Ala 
        195                 200                 205             


Pro Ala Ser Leu Cys Gln Leu Val Ala Gln Arg Tyr Thr Pro Leu Lys 
    210                 215                 220                 


Glu Val Leu Pro Leu Met Ala Ala Ala Gly Ser His Leu Leu Phe Val 
225                 230                 235                 240 


Leu His Gly Leu Glu His Leu Asn Leu Asp Phe Arg Leu Ala Gly Thr 
                245                 250                 255     


Gly Leu Cys Ser Asp Pro Glu Glu Pro Gln Glu Pro Ala Ala Ile Ile 
            260                 265                 270         


Val Asn Leu Leu Arg Lys Tyr Met Leu Pro Gln Ala Ser Ile Leu Val 
        275                 280                 285             


Thr Thr Arg Pro Ser Ala Ile Gly Arg Ile Pro Ser Lys Tyr Val Gly 
    290                 295                 300                 


Arg Tyr Gly Glu Ile Cys Gly Phe Ser Asp Thr Asn Leu Gln Lys Leu 
305                 310                 315                 320 


Tyr Phe Gln Leu Arg Leu Asn Gln Pro Tyr Cys Gly Tyr Ala Val Gly 
                325                 330                 335     


Gly Ser Gly Val Ser Ala Thr Pro Ala Gln Arg Asp His Leu Val Gln 
            340                 345                 350         


Met Leu Ser Arg Asn Leu Glu Gly His His Gln Ile Ala Ala Ala Cys 
        355                 360                 365             


Phe Leu Pro Ser Tyr Cys Trp Leu Val Cys Ala Thr Leu His Phe Leu 
    370                 375                 380                 


His Ala Pro Thr Pro Ala Gly Gln Thr Leu Thr Ser Ile Tyr Thr Ser 
385                 390                 395                 400 


Phe Leu Arg Leu Asn Phe Ser Gly Glu Thr Leu Asp Ser Thr Asp Pro 
                405                 410                 415     


Ser Asn Leu Ser Leu Met Ala Tyr Ala Ala Arg Thr Met Gly Lys Leu 
            420                 425                 430         


Ala Tyr Glu Gly Val Ser Ser Arg Lys Thr Tyr Phe Ser Glu Glu Asp 
        435                 440                 445             


Val Cys Gly Cys Leu Glu Ala Gly Ile Arg Thr Glu Glu Glu Phe Gln 
    450                 455                 460                 


Leu Leu His Ile Phe Arg Arg Asp Ala Leu Arg Phe Phe Leu Ala Pro 
465                 470                 475                 480 


Cys Val Glu Pro Gly Arg Ala Gly Thr Phe Val Phe Thr Val Pro Ala 
                485                 490                 495     


Met Gln Glu Tyr Leu Ala Ala Leu Tyr Ile Val Leu Gly Leu Arg Lys 
            500                 505                 510         


Thr Thr Leu Gln Lys Val Gly Lys Glu Val Ala Glu Leu Val Gly Arg 
        515                 520                 525             


Val Gly Glu Asp Val Ser Leu Val Leu Gly Ile Met Ala Lys Leu Leu 
    530                 535                 540                 


Pro Leu Arg Ala Leu Pro Leu Leu Phe Asn Leu Ile Lys Val Val Pro 
545                 550                 555                 560 


Arg Val Phe Gly Arg Met Val Gly Lys Ser Arg Glu Ala Val Ala Gln 
                565                 570                 575     


Ala Met Val Leu Glu Met Phe Arg Glu Glu Asp Tyr Tyr Asn Asp Asp 
            580                 585                 590         


Val Leu Asp Gln Met Gly Ala Ser Ile Leu Gly Val Glu Gly Pro Arg 
        595                 600                 605             


Arg His Pro Asp Glu Pro Pro Glu Asp Glu Val Phe Glu Leu Phe Pro 
    610                 615                 620                 


Met Phe Met Gly Gly Leu Leu Ser Ala His Asn Arg Ala Val Leu Ala 
625                 630                 635                 640 


Gln Leu Gly Cys Pro Ile Lys Asn Leu Asp Ala Leu Glu Asn Ala Gln 
                645                 650                 655     


Ala Ile Lys Lys Lys Leu Gly Lys Leu Gly Arg Gln Val Leu Pro Pro 
            660                 665                 670         


Ser Glu Leu Leu Asp His Leu Phe Phe His Tyr Glu Phe Gln Asn Gln 
        675                 680                 685             


Arg Phe Ser Ala Glu Val Leu Ser Ser Leu Arg Gln Leu Asn Leu Ala 
    690                 695                 700                 


Gly Val Arg Met Thr Pro Val Lys Cys Thr Val Val Ala Ala Val Leu 
705                 710                 715                 720 


Gly Ser Gly Arg His Ala Leu Asp Glu Val Asn Leu Ala Ser Cys Gln 
                725                 730                 735     


Leu Asp Pro Ala Gly Leu Arg Thr Leu Leu Pro Val Phe Leu Arg Ala 
            740                 745                 750         


Arg Lys Leu Gly Leu Gln Leu Asn Ser Leu Gly Pro Glu Ala Cys Lys 
        755                 760                 765             


Asp Leu Arg Asp Leu Leu Leu His Asp Gln Cys Gln Ile Thr Thr Leu 
    770                 775                 780                 


Arg Leu Ser Asn Asn Pro Leu Thr Ala Ala Gly Val Ala Val Leu Met 
785                 790                 795                 800 


Glu Gly Leu Ala Gly Asn Thr Ser Val Thr His Leu Ser Leu Leu His 
                805                 810                 815     


Thr Gly Leu Gly Asp Glu Gly Leu Glu Leu Leu Ala Ala Gln Leu Asp 
            820                 825                 830         


Arg Asn Arg Gln Leu Gln Glu Leu Asn Val Ala Tyr Asn Gly Ala Gly 
        835                 840                 845             


Asp Thr Ala Ala Leu Ala Leu Ala Arg Ala Ala Arg Glu His Pro Ser 
    850                 855                 860                 


Leu Glu Leu Leu Gln Gly Val Ala Ile Gln Met Cys Trp Lys Leu Pro 
865                 870                 875                 880 


Leu Leu Pro Tyr Ala His Leu Trp Thr Pro Arg Met Pro Ser His Trp 
                885                 890                 895     


Cys Phe Leu Leu Ile Leu Met Pro Pro Leu Pro Gln Trp Tyr Asp Gly 
            900                 905                 910         


Leu Val Ala Pro Arg Gly Arg Cys Thr 
        915                 920     


<210>  27
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly Glu Ser Ser Glu Asp Ile Asp Gln Met Phe Ser Thr Leu Leu 
1               5                   10                  15      


Gly Glu Met Asp Leu Leu Thr Gln Ser Leu Gly Val Asp Thr Leu Pro 
            20                  25                  30          


Pro Pro Asp Pro Asn Pro Pro Arg Ala Glu Phe Asn Tyr Ser Val Gly 
        35                  40                  45              


Phe Lys Asp Leu Asn Glu Ser Leu Asn Ala Leu Glu Asp Gln Asp Leu 
    50                  55                  60                  


Asp Ala Leu Met Ala Asp Leu Val Ala Asp Ile Ser Glu Ala Glu Gln 
65                  70                  75                  80  


Arg Thr Ile Gln Ala Gln Lys Glu Ser Leu Gln Asn Gln His His Ser 
                85                  90                  95      


Ala Ser Leu Gln Ala Ser Ile Phe Ser Gly Ala Ala Ser Leu Gly Tyr 
            100                 105                 110         


Gly Thr Asn Val Ala Ala Thr Gly Ile Ser Gln Tyr Glu Asp Asp Leu 
        115                 120                 125             


Pro Pro Pro Pro Ala Asp Pro Val Leu Asp Leu Pro Leu Pro Pro Pro 
    130                 135                 140                 


Pro Pro Glu Pro Leu Ser Gln Glu Glu Glu Glu Ala Gln Ala Lys Ala 
145                 150                 155                 160 


Asp Lys Ile Lys Leu Ala Leu Glu Lys Leu Lys Glu Ala Lys Val Lys 
                165                 170                 175     


Lys Leu Val Val Lys Val His Met Asn Asp Asn Ser Thr Lys Ser Leu 
            180                 185                 190         


Met Val Asp Glu Arg Gln Leu Ala Arg Asp Val Leu Asp Asn Leu Phe 
        195                 200                 205             


Glu Lys Thr His Cys Asp Cys Asn Val Asp Trp Cys Leu Tyr Glu Ile 
    210                 215                 220                 


Tyr Pro Glu Leu Gln Ile Glu Arg Phe Phe Glu Asp His Glu Asn Val 
225                 230                 235                 240 


Val Glu Val Leu Ser Asp Trp Thr Arg Asp Thr Glu Asn Lys Ile Leu 
                245                 250                 255     


Phe Leu Glu Lys Glu Glu Lys Tyr Ala Val Phe Lys Asn Pro Gln Asn 
            260                 265                 270         


Phe Tyr Leu Asp Asn Arg Gly Lys Lys Glu Ser Lys Glu Thr Asn Glu 
        275                 280                 285             


Lys Met Asn Ala Lys Asn Lys Glu Ser Leu Leu Glu Glu Ser Phe Cys 
    290                 295                 300                 


Gly Thr Ser Ile Ile Val Pro Glu Leu Glu Gly Ala Leu Tyr Leu Lys 
305                 310                 315                 320 


Glu Asp Gly Lys Lys Ser Trp Lys Arg Arg Tyr Phe Leu Leu Arg Ala 
                325                 330                 335     


Ser Gly Ile Tyr Tyr Val Pro Lys Gly Lys Thr Lys Thr Ser Arg Asp 
            340                 345                 350         


Leu Ala Cys Phe Ile Gln Phe Glu Asn Val Asn Ile Tyr Tyr Gly Thr 
        355                 360                 365             


Gln His Lys Met Lys Tyr Lys Ala Pro Thr Asp Tyr Cys Phe Val Leu 
    370                 375                 380                 


Lys His Pro Gln Ile Gln Lys Glu Ser Gln Tyr Ile Lys Tyr Leu Cys 
385                 390                 395                 400 


Cys Asp Asp Thr Arg Thr Leu Asn Gln Trp Val Met Gly Ile Arg Ile 
                405                 410                 415     


Ala Lys Tyr Gly Lys Thr Leu Tyr Asp Asn Tyr Gln Arg Ala Val Ala 
            420                 425                 430         


Lys Ala Gly Leu Ala Ser Arg Trp Thr Asn Leu Gly Thr Val Asn Ala 
        435                 440                 445             


Ala Ala Pro Ala Gln Pro Ser Thr Gly Pro Lys Thr Gly Thr Thr Gln 
    450                 455                 460                 


Pro Asn Gly Gln Ile Pro Gln Ala Thr His Ser Val Ser Ala Val Leu 
465                 470                 475                 480 


Gln Glu Ala Gln Arg His Ala Glu Thr Ser Lys Asp Lys Lys Pro Ala 
                485                 490                 495     


Leu Gly Asn His His Asp Pro Ala Val Pro Arg Ala Pro His Ala Pro 
            500                 505                 510         


Lys Ser Ser Leu Pro Pro Pro Pro Pro Val Arg Arg Ser Ser Asp Thr 
        515                 520                 525             


Ser Gly Ser Pro Ala Thr Pro Leu Lys Ala Lys Gly Thr Gly Gly Gly 
    530                 535                 540                 


Gly Leu Pro Ala Pro Pro Asp Asp Phe Leu Pro Pro Pro Pro Pro Pro 
545                 550                 555                 560 


Pro Pro Leu Asp Asp Pro Glu Leu Pro Pro Pro Pro Pro Asp Phe Met 
                565                 570                 575     


Glu Pro Pro Pro Asp Phe Val Pro Pro Pro Pro Pro Ser Tyr Ala Gly 
            580                 585                 590         


Ile Ala Gly Ser Glu Leu Pro Pro Pro Pro Pro Pro Pro Ala Pro Ala 
        595                 600                 605             


Pro Ala Pro Val Pro Asp Ser Ala Arg Pro Pro Pro Ala Val Ala Lys 
    610                 615                 620                 


Arg Pro Pro Val Pro Pro Lys Arg Gln Glu Asn Pro Gly His Pro Gly 
625                 630                 635                 640 


Gly Ala Gly Gly Gly Glu Gln Asp Phe Met Ser Asp Leu Met Lys Ala 
                645                 650                 655     


Leu Gln Lys Lys Arg Gly Asn Val Ser 
            660                 665 


<210>  28
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Asp Ile Cys Glu Ser Ile Leu Glu Arg Lys Arg His Asp Ser Glu 
1               5                   10                  15      


Arg Ser Thr Cys Ser Ile Leu Glu Gln Thr Asp Met Glu Ala Val Glu 
            20                  25                  30          


Ala Leu Val Cys Met Ser Ser Trp Gly Gln Arg Ser Gln Lys Gly Asp 
        35                  40                  45              


Leu Leu Arg Ile Arg Pro Leu Thr Pro Val Ser Asp Ser Gly Asp Val 
    50                  55                  60                  


Thr Thr Thr Val His Met Asp Ala Ala Thr Pro Glu Leu Pro Lys Asp 
65                  70                  75                  80  


Phe His Ser Leu Ser Thr Leu Cys Ile Thr Pro Pro Gln Ser Pro Asp 
                85                  90                  95      


Leu Val Glu Pro Ser Thr Arg Thr Pro Val Ser Pro Gln Val Thr Asp 
            100                 105                 110         


Ser Lys Ala Cys Thr Ala Thr Asp Val Leu Gln Ser Ser Ala Val Val 
        115                 120                 125             


Ala Arg Ala Leu Ser Gly Gly Ala Glu Arg Gly Leu Leu Gly Leu Glu 
    130                 135                 140                 


Pro Val Pro Ser Ser Pro Cys Arg Ala Lys Gly Thr Ser Val Ile Arg 
145                 150                 155                 160 


His Thr Gly Glu Ser Pro Ala Ala Cys Phe Pro Thr Ile Gln Thr Pro 
                165                 170                 175     


Asp Cys Arg Leu Ser Asp Ser Arg Glu Gly Glu Glu Gln Leu Leu Gly 
            180                 185                 190         


His Phe Glu Thr Leu Gln Asp Thr His Leu Thr Asp Ser Leu Leu Ser 
        195                 200                 205             


Thr Asn Leu Val Ser Cys Gln Pro Cys Leu His Lys Ser Gly Gly Leu 
    210                 215                 220                 


Leu Leu Thr Asp Lys Gly Gln Gln Ala Gly Trp Pro Gly Ala Val Gln 
225                 230                 235                 240 


Thr Cys Ser Pro Lys Asn Tyr Glu Asn Asp Leu Pro Arg Lys Thr Thr 
                245                 250                 255     


Pro Leu Ile Ser Val Ser Val Pro Ala Pro Pro Val Leu Cys Gln Met 
            260                 265                 270         


Ile Pro Val Thr Gly Gln Ser Ser Met Leu Pro Ala Phe Leu Lys Pro 
        275                 280                 285             


Pro Pro Gln Leu Ser Val Gly Thr Val Arg Pro Ile Leu Ala Gln Ala 
    290                 295                 300                 


Ala Pro Ala Pro Gln Pro Val Phe Val Gly Pro Ala Val Pro Gln Gly 
305                 310                 315                 320 


Ala Val Met Leu Val Leu Pro Gln Gly Ala Leu Pro Pro Pro Ala Pro 
                325                 330                 335     


Cys Ala Ala Asn Val Met Ala Ala Gly Asn Thr Lys Leu Leu Pro Leu 
            340                 345                 350         


Ala Pro Ala Pro Val Phe Ile Thr Ser Ser Gln Asn Cys Val Pro Gln 
        355                 360                 365             


Val Asp Phe Ser Arg Arg Arg Asn Tyr Val Cys Ser Phe Pro Gly Cys 
    370                 375                 380                 


Arg Lys Thr Tyr Phe Lys Ser Ser His Leu Lys Ala His Leu Arg Thr 
385                 390                 395                 400 


His Thr Gly Glu Lys Pro Phe Asn Cys Ser Trp Asp Gly Cys Asp Lys 
                405                 410                 415     


Lys Phe Ala Arg Ser Asp Glu Leu Ser Arg His Arg Arg Thr His Thr 
            420                 425                 430         


Gly Glu Lys Lys Phe Val Cys Pro Val Cys Asp Arg Arg Phe Met Arg 
        435                 440                 445             


Ser Asp His Leu Thr Lys His Ala Arg Arg His Met Thr Thr Lys Lys 
    450                 455                 460                 


Ile Pro Gly Trp Gln Ala Glu Val Gly Lys Leu Asn Arg Ile Ala Ser 
465                 470                 475                 480 


Ala Glu Ser Pro Gly Ser Pro Leu Val Ser Met Pro Ala Ser Ala 
                485                 490                 495 


<210>  29
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Trp Tyr His Arg Leu Ser His Leu His Ser Arg Leu Gln Asp Leu 
1               5                   10                  15      


Leu Lys Gly Gly Val Ile Tyr Pro Ala Leu Pro Gln Pro Asn Phe Lys 
            20                  25                  30          


Ser Leu Leu Pro Leu Ala Val His Trp His His Thr Ala Ser Lys Ser 
        35                  40                  45              


Leu Thr Cys Ala Trp Gln Gln His Glu Asp His Phe Glu Leu Lys Tyr 
    50                  55                  60                  


Ala Asn Thr Val Met Arg Phe Asp Tyr Val Trp Leu Arg Asp His Cys 
65                  70                  75                  80  


Arg Ser Ala Ser Cys Tyr Asn Ser Lys Thr His Gln Arg Ser Leu Asp 
                85                  90                  95      


Thr Ala Ser Val Asp Leu Cys Ile Lys Pro Lys Thr Ile Arg Leu Asp 
            100                 105                 110         


Glu Thr Thr Leu Phe Phe Thr Trp Pro Asp Gly His Val Thr Lys Tyr 
        115                 120                 125             


Asp Leu Asn Trp Leu Val Lys Asn Ser Tyr Glu Gly Gln Lys Gln Lys 
    130                 135                 140                 


Val Ile Gln Pro Arg Ile Leu Trp Asn Ala Glu Ile Tyr Gln Gln Ala 
145                 150                 155                 160 


Gln Val Pro Ser Val Asp Cys Gln Ser Phe Leu Glu Thr Asn Glu Gly 
                165                 170                 175     


Leu Lys Lys Phe Leu Gln Asn Phe Leu Leu Tyr Gly Ile Ala Phe Val 
            180                 185                 190         


Glu Asn Val Pro Pro Thr Gln Glu His Thr Glu Lys Leu Ala Glu Arg 
        195                 200                 205             


Ile Ser Leu Ile Arg Glu Thr Ile Tyr Gly Arg Met Trp Tyr Phe Thr 
    210                 215                 220                 


Ser Asp Phe Ser Arg Gly Asp Thr Ala Tyr Thr Lys Leu Ala Leu Asp 
225                 230                 235                 240 


Arg His Thr Asp Thr Thr Tyr Phe Gln Glu Pro Cys Gly Ile Gln Val 
                245                 250                 255     


Phe His Cys Leu Lys His Glu Gly Thr Gly Gly Arg Thr Leu Leu Val 
            260                 265                 270         


Asp Gly Phe Tyr Ala Ala Glu Gln Val Leu Gln Lys Ala Pro Glu Glu 
        275                 280                 285             


Phe Glu Leu Leu Ser Lys Val Pro Leu Lys His Glu Tyr Ile Glu Asp 
    290                 295                 300                 


Val Gly Glu Cys His Asn His Met Ile Gly Ile Gly Pro Val Leu Asn 
305                 310                 315                 320 


Ile Tyr Pro Trp Asn Lys Glu Leu Tyr Leu Ile Arg Leu Phe Lys Glu 
                325                 330                 335     


Lys Gln Asn Thr Val Asn Arg Gln Trp Asn Ser Ser Leu Gln Cys Asp 
            340                 345                 350         


Ile Pro Glu Arg Ile Leu Thr Tyr Arg His Phe Val Ser Gly Thr Ser 
        355                 360                 365             


Ile Glu His Arg Gly Ser Leu Ile 
    370                 375     


<210>  30
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asp Leu Ile Pro Asn Phe Ala Met Glu Thr Trp Val Leu Val Ala 
1               5                   10                  15      


Thr Ser Leu Val Leu Leu Tyr Ile Tyr Gly Thr His Ser His Gly Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Asn Ile Leu Ser Tyr His Lys Gly Phe Cys Met Phe Asp Met Glu Cys 
    50                  55                  60                  


His Lys Lys Tyr Gly Lys Val Trp Gly Phe Tyr Asp Gly Gln Gln Pro 
65                  70                  75                  80  


Val Leu Ala Ile Thr Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Pro Phe Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Ser Ala Ile Ser Ile Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Leu Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Thr Gly Lys Pro Val Thr Leu Lys Asp Val Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Asn 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Asn Thr Lys 
        195                 200                 205             


Lys Leu Leu Arg Phe Asp Phe Leu Asp Pro Phe Phe Leu Ser Ile Thr 
    210                 215                 220                 


Val Phe Pro Phe Leu Ile Pro Ile Leu Glu Val Leu Asn Ile Cys Val 
225                 230                 235                 240 


Phe Pro Arg Glu Val Thr Asn Phe Leu Arg Lys Ser Val Lys Arg Met 
                245                 250                 255     


Lys Glu Ser Arg Leu Glu Asp Thr Gln Lys His Arg Val Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Ile Met Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Leu Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Ile Ala Met Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Met Phe Ile Pro Lys Gly Val Val Val Met Ile Pro Ser Tyr Ala 
385                 390                 395                 400 


Leu His Arg Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Leu Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Asn Ile Asp Pro Tyr Ile Tyr 
            420                 425                 430         


Thr Pro Phe Gly Ser Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Ser Leu Gly 
465                 470                 475                 480 


Gly Leu Leu Gln Pro Glu Lys Pro Val Val Leu Lys Val Glu Ser Arg 
                485                 490                 495     


Asp Gly Thr Val Ser Gly Ala 
            500             


<210>  31
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Gln Arg Arg Ser Arg Gly Ile Asn Thr Gly Leu Ile Leu Leu Leu 
1               5                   10                  15      


Ser Gln Ile Phe His Val Gly Ile Asn Asn Ile Pro Pro Val Thr Leu 
            20                  25                  30          


Ala Thr Leu Ala Leu Asn Ile Trp Phe Phe Leu Asn Pro Gln Lys Pro 
        35                  40                  45              


Leu Tyr Ser Ser Cys Leu Ser Val Glu Lys Cys Tyr Gln Gln Lys Asp 
    50                  55                  60                  


Trp Gln Arg Leu Leu Leu Ser Pro Leu His His Ala Asp Asp Trp His 
65                  70                  75                  80  


Leu Tyr Phe Asn Met Ala Ser Met Leu Trp Lys Gly Ile Asn Leu Glu 
                85                  90                  95      


Arg Arg Leu Gly Ser Arg Trp Phe Ala Tyr Val Ile Thr Ala Phe Ser 
            100                 105                 110         


Val Leu Thr Gly Val Val Tyr Leu Leu Leu Gln Phe Ala Val Ala Glu 
        115                 120                 125             


Phe Met Asp Glu Pro Asp Phe Lys Arg Ser Cys Ala Val Gly Phe Ser 
    130                 135                 140                 


Gly Val Leu Phe Ala Leu Lys Val Leu Asn Asn His Tyr Cys Pro Gly 
145                 150                 155                 160 


Gly Phe Val Asn Ile Leu Gly Phe Pro Val Pro Asn Arg Phe Ala Cys 
                165                 170                 175     


Trp Val Glu Leu Val Ala Ile His Leu Phe Ser Pro Gly Thr Ser Phe 
            180                 185                 190         


Ala Gly His Leu Ala Gly Ile Leu Val Gly Leu Met Tyr Thr Gln Gly 
        195                 200                 205             


Pro Leu Lys Lys Ile Met Glu Ala Cys Ala Gly Gly Phe Ser Ser Ser 
    210                 215                 220                 


Val Gly Tyr Pro Gly Arg Gln Tyr Tyr Phe Asn Ser Ser Gly Ser Ser 
225                 230                 235                 240 


Gly Tyr Gln Asp Tyr Tyr Pro His Gly Arg Pro Asp His Tyr Glu Glu 
                245                 250                 255     


Ala Pro Arg Asn Tyr Asp Thr Tyr Thr Ala Gly Leu Ser Glu Glu Glu 
            260                 265                 270         


Gln Leu Glu Arg Ala Leu Gln Ala Ser Leu Trp Asp Arg Gly Asn Thr 
        275                 280                 285             


Arg Asn Ser Pro Pro Pro Tyr Gly Phe His Leu Ser Pro Glu Glu Met 
    290                 295                 300                 


Arg Arg Gln Arg Leu His Arg Phe Asp Ser Gln 
305                 310                 315 


<210>  32
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asp Gly Glu Glu Gln Gln Pro Pro His Glu Ala Asn Val Glu Pro 
1               5                   10                  15      


Val Val Pro Ser Glu Ala Ser Glu Pro Val Pro Arg Val Leu Ser Gly 
            20                  25                  30          


Asp Pro Gln Asn Leu Ser Asp Val Asp Ala Phe Asn Leu Leu Leu Glu 
        35                  40                  45              


Met Lys Leu Lys Arg Arg Arg Gln Arg Pro Asn Leu Pro Arg Thr Val 
    50                  55                  60                  


Thr Gln Leu Val Ala Glu Asp Gly Ser Arg Val Tyr Val Val Gly Thr 
65                  70                  75                  80  


Ala His Phe Ser Asp Asp Ser Lys Arg Asp Val Val Lys Thr Ile Arg 
                85                  90                  95      


Glu Val Gln Pro Asp Val Val Val Val Glu Leu Cys Gln Tyr Arg Val 
            100                 105                 110         


Ser Met Leu Lys Met Asp Glu Ser Thr Leu Leu Arg Glu Ala Gln Glu 
        115                 120                 125             


Leu Ser Leu Glu Lys Leu Gln Gln Ala Val Arg Gln Asn Gly Leu Met 
    130                 135                 140                 


Ser Gly Leu Met Gln Met Leu Leu Leu Lys Val Ser Ala His Ile Thr 
145                 150                 155                 160 


Glu Gln Leu Gly Met Ala Pro Gly Gly Glu Phe Arg Glu Ala Phe Lys 
                165                 170                 175     


Glu Ala Ser Lys Val Pro Phe Cys Lys Phe His Leu Gly Asp Arg Pro 
            180                 185                 190         


Ile Pro Val Thr Phe Lys Arg Ala Ile Ala Ala Leu Ser Phe Trp Gln 
        195                 200                 205             


Lys Val Arg Leu Ala Trp Gly Leu Cys Phe Leu Ser Asp Pro Ile Ser 
    210                 215                 220                 


Lys Asp Asp Val Glu Arg Cys Lys Gln Lys Asp Leu Leu Glu Gln Met 
225                 230                 235                 240 


Met Ala Glu Met Ile Gly Glu Phe Pro Asp Leu His Arg Thr Ile Val 
                245                 250                 255     


Ser Glu Arg Asp Val Tyr Leu Thr Tyr Met Leu Arg Gln Ala Ala Arg 
            260                 265                 270         


Arg Leu Glu Leu Pro Arg Ala Ser Asp Ala Glu Pro Arg Lys Cys Val 
        275                 280                 285             


Pro Ser Val Val Val Gly Val Val Gly Met Gly His Val Pro Gly Ile 
    290                 295                 300                 


Glu Lys Asn Trp Ser Thr Asp Leu Asn Ile Gln Glu Ile Met Thr Val 
305                 310                 315                 320 


Pro Pro Pro Ser Val Ser Gly Arg Val Ser Arg Leu Ala Val Lys Ala 
                325                 330                 335     


Ala Phe Phe Gly Leu Leu Gly Tyr Ser Leu Tyr Trp Met Gly Arg Arg 
            340                 345                 350         


Thr Ala Ser Leu Val Leu Ser Leu Pro Ala Ala Gln Tyr Cys Leu Gln 
        355                 360                 365             


Arg Val Thr Glu Ala Arg His Lys 
    370                 375     


<210>  33
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Lys Lys Ser Arg Val Lys Thr Gln Lys Ser Gly Thr Gly Ala 
1               5                   10                  15      


Thr Ala Thr Val Ser Pro Lys Glu Ile Leu Asn Leu Thr Ser Glu Leu 
            20                  25                  30          


Leu Gln Lys Cys Ser Ser Pro Ala Pro Gly Pro Gly Lys Glu Trp Glu 
        35                  40                  45              


Glu Tyr Val Gln Ile Arg Thr Leu Val Glu Lys Ile Arg Lys Lys Gln 
    50                  55                  60                  


Lys Gly Leu Ser Val Thr Phe Asp Gly Lys Arg Glu Asp Tyr Phe Pro 
65                  70                  75                  80  


Asp Leu Met Lys Trp Ala Ser Glu Asn Gly Ala Ser Val Glu Gly Phe 
                85                  90                  95      


Glu Met Val Asn Phe Lys Glu Glu Gly Phe Gly Leu Arg Ala Thr Arg 
            100                 105                 110         


Asp Ile Lys Ala Glu Glu Leu Phe Leu Trp Val Pro Arg Lys Leu Leu 
        115                 120                 125             


Met Thr Val Glu Ser Ala Lys Asn Ser Val Leu Gly Pro Leu Tyr Ser 
    130                 135                 140                 


Gln Asp Arg Ile Leu Gln Ala Met Gly Asn Ile Ala Leu Ala Phe His 
145                 150                 155                 160 


Leu Leu Cys Glu Arg Ala Ser Pro Asn Ser Phe Trp Gln Pro Tyr Ile 
                165                 170                 175     


Gln Thr Leu Pro Ser Glu Tyr Asp Thr Pro Leu Tyr Phe Glu Glu Asp 
            180                 185                 190         


Glu Val Arg Tyr Leu Gln Ser Thr Gln Ala Ile His Asp Val Phe Ser 
        195                 200                 205             


Gln Tyr Lys Asn Thr Ala Arg Gln Tyr Ala Tyr Phe Tyr Lys Val Ile 
    210                 215                 220                 


Gln Thr His Pro His Ala Asn Lys Leu Pro Leu Lys Asp Ser Phe Thr 
225                 230                 235                 240 


Tyr Glu Asp Tyr Arg Trp Ala Val Ser Ser Val Met Thr Arg Gln Asn 
                245                 250                 255     


Gln Ile Pro Thr Glu Asp Gly Ser Arg Val Thr Leu Ala Leu Ile Pro 
            260                 265                 270         


Leu Trp Asp Met Cys Asn His Thr Asn Gly Leu Thr Pro Glu Asp Ser 
        275                 280                 285             


Phe Ala Leu Ala Val Ala Ser Ala 
    290                 295     


<210>  34
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Asp His Leu Gly Ala Ser Leu Trp Pro Gln Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Leu Pro Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Gly Asn Tyr Ser Phe Ser 
65                  70                  75                  80  


Tyr Gln Leu Glu Asp Glu Pro Trp Lys Leu Cys Arg Leu His Gln Ala 
                85                  90                  95      


Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala Ser 
        115                 120                 125             


Gly Ala Pro Arg Tyr His Arg Val Ile His Ile Asn Glu Val Val Leu 
    130                 135                 140                 


Leu Asp Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly 
145                 150                 155                 160 


His Val Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser 
                165                 170                 175     


His Ile Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser 
            180                 185                 190         


Val Gln Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser 
        195                 200                 205             


Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met 
    210                 215                 220                 


Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val 
225                 230                 235                 240 


Ser Leu Leu Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
                245                 250                 255     


Leu Ile Leu Val Val Ile Leu Val Leu Leu Thr Val Leu Ala Leu Leu 
            260                 265                 270         


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
        275                 280                 285             


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
    290                 295                 300                 


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
305                 310                 315                 320 


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
                325                 330                 335     


Arg Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu 
            340                 345                 350         


Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr 
        355                 360                 365             


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
    370                 375                 380                 


Leu Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly 
385                 390                 395                 400 


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro 
                405                 410                 415     


Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
            420                 425                 430         


Ser Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr 
        435                 440                 445             


Pro Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile 
    450                 455                 460                 


Ser Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu 
465                 470                 475                 480 


Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
                485                 490                 495     


Ala Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
            500                 505             


<210>  35
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Glu Thr Asn Phe Ser Thr Pro Leu Asn Glu Tyr Glu Glu Val Ser 
1               5                   10                  15      


Tyr Glu Ser Ala Gly Tyr Thr Val Leu Arg Ile Leu Pro Leu Val Val 
            20                  25                  30          


Leu Gly Val Thr Phe Val Leu Gly Val Leu Gly Asn Gly Leu Val Ile 
        35                  40                  45              


Trp Val Ala Gly Phe Arg Met Thr Arg Thr Val Thr Thr Ile Cys Tyr 
    50                  55                  60                  


Leu Asn Leu Ala Leu Ala Asp Phe Ser Phe Thr Ala Thr Leu Pro Phe 
65                  70                  75                  80  


Leu Ile Val Ser Met Ala Met Gly Glu Lys Trp Pro Phe Gly Trp Phe 
                85                  90                  95      


Leu Cys Lys Leu Ile His Ile Val Val Asp Ile Asn Leu Phe Gly Ser 
            100                 105                 110         


Val Phe Leu Ile Gly Phe Ile Ala Leu Asp Arg Cys Ile Cys Val Leu 
        115                 120                 125             


His Pro Val Trp Ala Gln Asn His Arg Thr Val Ser Leu Ala Met Lys 
    130                 135                 140                 


Val Ile Val Gly Pro Trp Ile Leu Ala Leu Val Leu Thr Leu Pro Val 
145                 150                 155                 160 


Phe Leu Phe Leu Thr Thr Val Thr Ile Pro Asn Gly Asp Thr Tyr Cys 
                165                 170                 175     


Thr Phe Asn Phe Ala Ser Trp Gly Gly Thr Pro Glu Glu Arg Leu Lys 
            180                 185                 190         


Val Ala Ile Thr Met Leu Thr Ala Arg Gly Ile Ile Arg Phe Val Ile 
        195                 200                 205             


Gly Phe Ser Leu Pro Met Ser Ile Val Ala Ile Cys Tyr Gly Leu Ile 
    210                 215                 220                 


Ala Ala Lys Ile His Lys Lys Gly Met Ile Lys Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Arg Val Leu Thr Ala Val Val Ala Ser Phe Phe Ile Cys Trp Phe Pro 
                245                 250                 255     


Phe Gln Leu Val Ala Leu Leu Gly Thr Val Trp Leu Lys Glu Met Leu 
            260                 265                 270         


Phe Tyr Gly Lys Tyr Lys Ile Ile Asp Ile Leu Val Asn Pro Thr Ser 
        275                 280                 285             


Ser Leu Ala Phe Phe Asn Ser Cys Leu Asn Pro Met Leu Tyr Val Phe 
    290                 295                 300                 


Val Gly Gln Asp Phe Arg Glu Arg Leu Ile His Ser Leu Pro Thr Ser 
305                 310                 315                 320 


Leu Glu Arg Ala Leu Ser Glu Asp Ser Ala Pro Thr Asn Asp Thr Ala 
                325                 330                 335     


Ala Asn Ser Ala Ser Pro Pro Ala Glu Thr Glu Leu Gln Ala Met 
            340                 345                 350     


<210>  36
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asn Cys Gln Gln Leu Trp Leu Gly Phe Leu Leu Pro Met Thr Val 
1               5                   10                  15      


Ser Gly Arg Val Leu Gly Leu Ala Glu Val Ala Pro Val Asp Tyr Leu 
            20                  25                  30          


Ser Gln Tyr Gly Tyr Leu Gln Lys Pro Leu Glu Gly Ser Asn Asn Phe 
        35                  40                  45              


Lys Pro Glu Asp Ile Thr Glu Ala Leu Arg Ala Phe Gln Glu Ala Ser 
    50                  55                  60                  


Glu Leu Pro Val Ser Gly Gln Leu Asp Asp Ala Thr Arg Ala Arg Met 
65                  70                  75                  80  


Arg Gln Pro Arg Cys Gly Leu Glu Asp Pro Phe Asn Gln Lys Thr Leu 
                85                  90                  95      


Lys Tyr Leu Leu Leu Gly Arg Trp Arg Lys Lys His Leu Thr Phe Arg 
            100                 105                 110         


Ile Leu Asn Leu Pro Ser Thr Leu Pro Pro His Thr Ala Arg Ala Ala 
        115                 120                 125             


Leu Arg Gln Ala Phe Gln Asp Trp Ser Asn Val Ala Pro Leu Thr Phe 
    130                 135                 140                 


Gln Glu Val Gln Ala Gly Ala Ala Asp Ile Arg Leu Ser Phe His Gly 
145                 150                 155                 160 


Arg Gln Ser Ser Tyr Cys Ser Asn Thr Phe Asp Gly Pro Gly Arg Val 
                165                 170                 175     


Leu Ala His Ala Asp Ile Pro Glu Leu Gly Ser Val His Phe Asp Glu 
            180                 185                 190         


Asp Glu Phe Trp Thr Glu Gly Thr Tyr Arg Gly Val Asn Leu Arg Ile 
        195                 200                 205             


Ile Ala Ala His Glu Val Gly His Ala Leu Gly Leu Gly His Ser Arg 
    210                 215                 220                 


Tyr Ser Gln Ala Leu Met Ala Pro Val Tyr Glu Gly Tyr Arg Pro His 
225                 230                 235                 240 


Phe Lys Leu His Pro Asp Asp Val Ala Gly Ile Gln Ala Leu Tyr Gly 
                245                 250                 255     


Lys Lys Ser Pro Val Ile Arg Asp Glu Glu Glu Glu Glu Thr Glu Leu 
            260                 265                 270         


Pro Thr Val Pro Pro Val Pro Thr Glu Pro Ser Pro Met Pro Asp Pro 
        275                 280                 285             


Cys Ser Ser Glu Leu Asp Ala Met Met Leu Gly Pro Arg Gly Lys Thr 
    290                 295                 300                 


Tyr Ala Phe Lys Gly Asp Tyr Val Trp Thr Val Ser Asp Ser Gly Pro 
305                 310                 315                 320 


Gly Pro Leu Phe Arg Val Ser Ala Leu Trp Glu Gly Leu Pro Gly Asn 
                325                 330                 335     


Leu Asp Ala Ala Val Tyr Ser Pro Arg Thr Gln Trp Ile His Phe Phe 
            340                 345                 350         


Lys Gly Asp Lys Val Trp Arg Tyr Ile Asn Phe Lys Met Ser Pro Gly 
        355                 360                 365             


Phe Pro Lys Lys Leu Asn Arg Val Glu Pro Asn Leu Asp Ala Ala Leu 
    370                 375                 380                 


Tyr Trp Pro Leu Asn Gln Lys Val Phe Leu Phe Lys Gly Ser Gly Tyr 
385                 390                 395                 400 


Trp Gln Trp Asp Glu Leu Ala Arg Thr Asp Phe Ser Ser Tyr Pro Lys 
                405                 410                 415     


Pro Ile Lys Gly Leu Phe Thr Gly Val Pro Asn Gln Pro Ser Ala Ala 
            420                 425                 430         


Met Ser Trp Gln Asp Gly Arg Val Tyr Phe Phe Lys Gly Lys Val Tyr 
        435                 440                 445             


Trp Arg Leu Asn Gln Gln Leu Arg Val Glu Lys Gly Tyr Pro Arg Asn 
    450                 455                 460                 


Ile Ser His Asn Trp Met His Cys Arg Pro Arg Thr Ile Asp Thr Thr 
465                 470                 475                 480 


Pro Ser Gly Gly Asn Thr Thr Pro Ser Gly Thr Gly Ile Thr Leu Asp 
                485                 490                 495     


Thr Thr Leu Ser Ala Thr Glu Thr Thr Phe Glu Tyr 
            500                 505             


<210>  37
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Val Gln Gln Thr Asn Asn Ala Glu Asn Thr Glu Ala Leu Leu Ala 
1               5                   10                  15      


Gly Glu Ser Ser Asp Ser Gly Ala Gly Leu Glu Leu Gly Ile Ala Ser 
            20                  25                  30          


Ser Pro Thr Pro Gly Ser Thr Ala Ser Thr Gly Gly Lys Ala Asp Asp 
        35                  40                  45              


Pro Ser Trp Cys Lys Thr Pro Ser Gly His Ile Lys Arg Pro Met Asn 
    50                  55                  60                  


Ala Phe Met Val Trp Ser Gln Ile Glu Arg Arg Lys Ile Met Glu Gln 
65                  70                  75                  80  


Ser Pro Asp Met His Asn Ala Glu Ile Ser Lys Arg Leu Gly Lys Arg 
                85                  90                  95      


Trp Lys Leu Leu Lys Asp Ser Asp Lys Ile Pro Phe Ile Arg Glu Ala 
            100                 105                 110         


Glu Arg Leu Arg Leu Lys His Met Ala Asp Tyr Pro Asp Tyr Lys Tyr 
        115                 120                 125             


Arg Pro Arg Lys Lys Val Lys Ser Gly Asn Ala Asn Ser Ser Ser Ser 
    130                 135                 140                 


Ala Ala Ala Ser Ser Lys Pro Gly Glu Lys Gly Asp Lys Val Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly His Gly Gly Gly Gly Gly Gly Gly Ser Ser Asn 
                165                 170                 175     


Ala Gly Gly Gly Gly Gly Gly Ala Ser Gly Gly Gly Ala Asn Ser Lys 
            180                 185                 190         


Pro Ala Gln Lys Lys Ser Cys Gly Ser Lys Val Ala Gly Gly Ala Gly 
        195                 200                 205             


Gly Gly Val Ser Lys Pro His Ala Lys Leu Ile Leu Ala Gly Gly Gly 
    210                 215                 220                 


Gly Gly Gly Lys Ala Ala Ala Ala Ala Ala Ala Ser Phe Ala Ala Glu 
225                 230                 235                 240 


Gln Ala Gly Ala Ala Ala Leu Leu Pro Leu Gly Ala Ala Ala Asp His 
                245                 250                 255     


His Ser Leu Tyr Lys Ala Arg Thr Pro Ser Ala Ser Ala Ser Ala Ser 
            260                 265                 270         


Ser Ala Ala Ser Ala Ser Ala Ala Leu Ala Ala Pro Gly Lys His Leu 
        275                 280                 285             


Ala Glu Lys Lys Val Lys Arg Val Tyr Leu Phe Gly Gly Leu Gly Thr 
    290                 295                 300                 


Ser Ser Ser Pro Val Gly Gly Val Gly Ala Gly Ala Asp Pro Ser Asp 
305                 310                 315                 320 


Pro Leu Gly Leu Tyr Glu Glu Glu Gly Ala Gly Cys Ser Pro Asp Ala 
                325                 330                 335     


Pro Ser Leu Ser Gly Arg Ser Ser Ala Ala Ser Ser Pro Ala Ala Gly 
            340                 345                 350         


Arg Ser Pro Ala Asp His Arg Gly Tyr Ala Ser Leu Arg Ala Ala Ser 
        355                 360                 365             


Pro Ala Pro Ser Ser Ala Pro Ser His Ala Ser Ser Ser Ala Ser Ser 
    370                 375                 380                 


His Ser Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Asp Asp Glu 
385                 390                 395                 400 


Phe Glu Asp Asp Leu Leu Asp Leu Asn Pro Ser Ser Asn Phe Glu Ser 
                405                 410                 415     


Met Ser Leu Gly Ser Phe Ser Ser Ser Ser Ala Leu Asp Arg Asp Leu 
            420                 425                 430         


Asp Phe Asn Phe Glu Pro Gly Ser Gly Ser His Phe Glu Phe Pro Asp 
        435                 440                 445             


Tyr Cys Thr Pro Glu Val Ser Glu Met Ile Ser Gly Asp Trp Leu Glu 
    450                 455                 460                 


Ser Ser Ile Ser Asn Leu Val Phe Thr Tyr 
465                 470                 


<210>  38
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Phe Arg Arg Pro Val Leu Gln Val Leu Arg Gln Phe Val Arg His 
1               5                   10                  15      


Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Ser Leu Asn Arg 
            20                  25                  30          


Val His Leu Leu Gly Arg Val Gly Gln Asp Pro Val Leu Arg Gln Val 
        35                  40                  45              


Glu Gly Lys Asn Pro Val Thr Ile Phe Ser Leu Ala Thr Asn Glu Met 
    50                  55                  60                  


Trp Arg Ser Gly Asp Ser Glu Val Tyr Gln Leu Gly Asp Val Ser Gln 
65                  70                  75                  80  


Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro Gly Leu Arg Asp 
                85                  90                  95      


Val Ala Tyr Gln Tyr Val Lys Lys Gly Ser Arg Ile Tyr Leu Glu Gly 
            100                 105                 110         


Lys Ile Asp Tyr Gly Glu Tyr Met Asp Lys Asn Asn Val Arg Arg Gln 
        115                 120                 125             


Ala Thr Thr Ile Ile Ala Asp Asn Ile Ile Phe Leu Ser Asp Gln Thr 
    130                 135                 140                 


Lys Glu Lys Glu 
145             


<210>  39
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Lys Thr Gly Leu Ser Ile Arg Gly Ala Gln Glu Glu Asp Pro Pro 
1               5                   10                  15      


Asp Pro Gln Leu Met Arg Leu Asp Asn Met Leu Leu Ala Glu Gly Val 
            20                  25                  30          


Ser Gly Pro Glu Lys Gly Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Ala Ala Ser Gly Gly Ser Ser Asp Asn Ser Ile Glu His Ser Asp Tyr 
    50                  55                  60                  


Arg Ala Lys Leu Thr Gln Ile Arg Gln Ile Tyr His Thr Glu Leu Glu 
65                  70                  75                  80  


Lys Tyr Glu Gln Ala Cys Asn Glu Phe Thr Thr His Val Met Asn Leu 
                85                  90                  95      


Leu Arg Glu Gln Ser Arg Thr Arg Pro Ile Ser Pro Lys Glu Ile Glu 
            100                 105                 110         


Arg Met Val Gly Ile Ile His Arg Lys Phe Ser Ser Ile Gln Met Gln 
        115                 120                 125             


Leu Lys Gln Ser Thr Cys Glu Ala Val Met Ile Leu Arg Ser Arg Phe 
    130                 135                 140                 


Leu Asp Ala Arg Arg Lys Arg Arg Asn Phe Ser Lys Gln Ala Thr Glu 
145                 150                 155                 160 


Ile Leu Asn Glu Tyr Phe Tyr Ser His Leu Ser Asn Pro Tyr Pro Ser 
                165                 170                 175     


Glu Glu Ala Lys Glu Glu Leu Ala Lys Lys Cys Ser Ile Thr Val Ser 
            180                 185                 190         


Gln Ser Leu Val Lys Asp Pro Lys Glu Arg Gly Ser Lys Gly Ser Asp 
        195                 200                 205             


Ile Gln Pro Thr Ser Val Val Ser Asn Trp Phe Gly Asn Lys Arg Ile 
    210                 215                 220                 


Arg Tyr Lys Lys Asn Ile Gly Lys Phe Gln Glu Glu Ala Asn Leu Tyr 
225                 230                 235                 240 


Ala Ala Lys Thr Ala Val Thr Ala Ala His Ala Val Ala Ala Ala Val 
                245                 250                 255     


Gln Asn Asn Gln Thr Asn Ser Pro Thr Thr Pro Asn Ser Gly Ser Ser 
            260                 265                 270         


Gly Ser Phe Asn Leu Pro Asn Ser Gly Asp Met Phe Met Asn Met Gln 
        275                 280                 285             


Ser Leu Asn Gly Asp Ser Tyr Gln Gly Ser Gln Val Gly Ala Asn Val 
    290                 295                 300                 


Gln Ser Gln Val Asp Thr Leu Arg His Val Ile Asn Gln Thr Gly Gly 
305                 310                 315                 320 


Tyr Ser Asp Gly Leu Gly Gly Asn Ser Leu Tyr Ser Pro His Asn Leu 
                325                 330                 335     


Asn Ala Asn Gly Gly Trp Gln Asp Ala Thr Thr Pro Ser Ser Val Thr 
            340                 345                 350         


Ser Pro Thr Glu Gly Pro Gly Ser Val His Ser Asp Thr Ser Asn 
        355                 360                 365         


<210>  40
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  41
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ser Arg Val Val Pro Gly Gln Phe Asp Asp Ala Asp Ser Ser Asp 
1               5                   10                  15      


Ser Glu Asn Arg Asp Leu Lys Thr Val Lys Glu Lys Asp Asp Ile Leu 
            20                  25                  30          


Phe Glu Asp Leu Gln Asp Asn Val Asn Glu Asn Gly Glu Gly Glu Ile 
        35                  40                  45              


Glu Asp Glu Glu Glu Glu Gly Tyr Asp Asp Asp Asp Asp Asp Trp Asp 
    50                  55                  60                  


Trp Asp Glu Gly Val Gly Lys Leu Ala Lys Gly Tyr Val Trp Asn Gly 
65                  70                  75                  80  


Gly Ser Asn Pro Gln Ala Asn Arg Gln Thr Ser Asp Ser Ser Ser Ala 
                85                  90                  95      


Lys Met Ser Thr Pro Ala Asp Lys Val Leu Arg Lys Phe Glu Asn Lys 
            100                 105                 110         


Ile Asn Leu Asp Lys Leu Asn Val Thr Asp Ser Val Ile Asn Lys Val 
        115                 120                 125             


Thr Glu Lys Ser Arg Gln Lys Glu Ala Asp Met Tyr Arg Ile Lys Asp 
    130                 135                 140                 


Lys Ala Asp Arg Ala Thr Val Glu Gln Val Leu Asp Pro Arg Thr Arg 
145                 150                 155                 160 


Met Ile Leu Phe Lys Met Leu Thr Arg Gly Ile Ile Thr Glu Ile Asn 
                165                 170                 175     


Gly Cys Ile Ser Thr Gly Lys Glu Ala Asn Val Tyr His Ala Ser Thr 
            180                 185                 190         


Ala Asn Gly Glu Ser Arg Ala Ile Lys Ile Tyr Lys Thr Ser Ile Leu 
        195                 200                 205             


Val Phe Lys Asp Arg Asp Lys Tyr Val Ser Gly Glu Phe Arg Phe Arg 
    210                 215                 220                 


His Gly Tyr Cys Lys Gly Asn Pro Arg Lys Met Val Lys Thr Trp Ala 
225                 230                 235                 240 


Glu Lys Glu Met Arg Asn Leu Ile Arg Leu Asn Thr Ala Glu Ile Pro 
                245                 250                 255     


Cys Pro Glu Pro Ile Met Leu Arg Ser His Val Leu Val Met Ser Phe 
            260                 265                 270         


Ile Gly Lys Asp Asp Met Pro Ala Pro Leu Leu Lys Asn Val Gln Leu 
        275                 280                 285             


Ser Glu Ser Lys Ala Arg Glu Leu Tyr Leu Gln Val Ile Gln Tyr Met 
    290                 295                 300                 


Arg Arg Met Tyr Gln Asp Ala Arg Leu Val His Ala Asp Leu Ser Glu 
305                 310                 315                 320 


Phe Asn Met Leu Tyr His Gly Gly Gly Val Tyr Ile Ile Asp Val Ser 
                325                 330                 335     


Gln Ser Val Glu His Asp His Pro His Ala Leu Glu Phe Leu Arg Lys 
            340                 345                 350         


Asp Cys Ala Asn Val Asn Asp Phe Phe Met Arg His Ser Val Ala Val 
        355                 360                 365             


Met Thr Val Arg Glu Leu Phe Glu Phe Val Thr Asp Pro Ser Ile Thr 
    370                 375                 380                 


His Glu Asn Met Asp Ala Tyr Leu Ser Lys Ala Met Glu Ile Ala Ser 
385                 390                 395                 400 


Gln Arg Thr Lys Glu Glu Arg Ser Ser Gln Asp His Val Asp Glu Glu 
                405                 410                 415     


Val Phe Lys Arg Ala Tyr Ile Pro Arg Thr Leu Asn Glu Val Lys Asn 
            420                 425                 430         


Tyr Glu Arg Asp Met Asp Ile Ile Met Lys Leu Lys Glu Glu Asp Met 
        435                 440                 445             


Ala Met Asn Ala Gln Gln Asp Asn Ile Leu Tyr Gln Thr Val Thr Gly 
    450                 455                 460                 


Leu Lys Lys Asp Leu Ser Gly Val Gln Lys Val Pro Ala Leu Leu Glu 
465                 470                 475                 480 


Asn Gln Val Glu Glu Arg Thr Cys Ser Asp Ser Glu Asp Ile Gly Ser 
                485                 490                 495     


Ser Glu Cys Ser Asp Thr Asp Ser Glu Glu Gln Gly Asp His Ala Arg 
            500                 505                 510         


Pro Lys Lys His Thr Thr Asp Pro Asp Ile Asp Lys Lys Glu Arg Lys 
        515                 520                 525             


Lys Met Val Lys Glu Ala Gln Arg Glu Lys Arg Lys Asn Lys Ile Pro 
    530                 535                 540                 


Lys His Val Lys Lys Arg Lys Glu Lys Thr Ala Lys Thr Lys Lys Gly 
545                 550                 555                 560 


Lys 
    


<210>  42
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  42

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      


Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          


Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              


Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  


Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  


Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         


<210>  43
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Trp Gly Ala Cys Lys Val Lys Val His Asp Ser Leu Ala Thr Ile 
1               5                   10                  15      


Ser Ile Thr Leu Arg Arg Tyr Leu Arg Leu Gly Ala Thr Met Ala Lys 
            20                  25                  30          


Ser Lys Phe Glu Tyr Val Arg Asp Phe Glu Ala Asp Asp Thr Cys Leu 
        35                  40                  45              


Ala His Cys Trp Val Val Val Arg Leu Asp Gly Arg Asn Phe His Arg 
    50                  55                  60                  


Phe Ala Glu Lys His Asn Phe Ala Lys Pro Asn Asp Ser Arg Ala Leu 
65                  70                  75                  80  


Gln Leu Met Thr Lys Cys Ala Gln Thr Val Met Glu Glu Leu Glu Asp 
                85                  90                  95      


Ile Val Ile Ala Tyr Gly Gln Ser Asp Glu Tyr Ser Phe Val Phe Lys 
            100                 105                 110         


Arg Lys Thr Asn Trp Phe Lys Arg Arg Ala Ser Lys Phe Met Thr His 
        115                 120                 125             


Val Ala Ser Gln Phe Ala Ser Ser Tyr Val Phe Tyr Trp Arg Asp Tyr 
    130                 135                 140                 


Phe Glu Asp Gln Pro Leu Leu Tyr Pro Pro Gly Phe Asp Gly Arg Val 
145                 150                 155                 160 


Val Val Tyr Pro Ser Asn Gln Thr Leu Lys Asp Tyr Leu Ser Trp Arg 
                165                 170                 175     


Gln Ala Asp Cys His Ile Asn Asn Leu Tyr Asn Thr Val Phe Trp Ala 
            180                 185                 190         


Leu Ile Gln Gln Ser Gly Leu Thr Pro Val Gln Ala Gln Gly Arg Leu 
        195                 200                 205             


Gln Gly Thr Leu Ala Ala Asp Lys Asn Glu Ile Leu Phe Ser Glu Phe 
    210                 215                 220                 


Asn Ile Asn Tyr Asn Asn Glu Pro Pro Met Tyr Arg Lys Gly Thr Val 
225                 230                 235                 240 


Leu Ile Trp Gln Lys Val Asp Glu Val Met Thr Lys Glu Ile Lys Leu 
                245                 250                 255     


Pro Thr Glu Met Glu Gly Lys Lys Met Ala Val Thr Arg Thr Arg Thr 
            260                 265                 270         


Lys Pro Val Pro Leu His Cys Asp Ile Ile Gly Asp Ala Phe Trp Lys 
        275                 280                 285             


Glu His Pro Glu Ile Leu Asp Glu Asp Ser 
    290                 295             


<210>  44
<211>  545
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Leu Leu Leu His Arg Ala Val Val Leu Arg Leu Gln Gln Ala Cys 
1               5                   10                  15      


Arg Leu Lys Ser Ile Pro Ser Arg Ile Cys Ile Gln Ala Cys Ser Thr 
            20                  25                  30          


Asn Asp Ser Phe Gln Pro Gln Arg Pro Ser Leu Thr Phe Ser Gly Asp 
        35                  40                  45              


Asn Ser Ser Thr Gln Gly Trp Arg Val Met Gly Thr Leu Leu Gly Leu 
    50                  55                  60                  


Gly Ala Val Leu Ala Tyr Gln Asp His Arg Cys Arg Ala Ala Gln Glu 
65                  70                  75                  80  


Ser Thr His Ile Tyr Thr Lys Glu Glu Val Ser Ser His Thr Ser Pro 
                85                  90                  95      


Glu Thr Gly Ile Trp Val Thr Leu Gly Ser Glu Val Phe Asp Val Thr 
            100                 105                 110         


Glu Phe Val Asp Leu His Pro Gly Gly Pro Ser Lys Leu Met Leu Ala 
        115                 120                 125             


Ala Gly Gly Pro Leu Glu Pro Phe Trp Ala Leu Tyr Ala Val His Asn 
    130                 135                 140                 


Gln Ser His Val Arg Glu Leu Leu Ala Gln Tyr Lys Ile Gly Glu Leu 
145                 150                 155                 160 


Asn Pro Glu Asp Lys Val Ala Pro Thr Val Glu Thr Ser Asp Pro Tyr 
                165                 170                 175     


Ala Asp Asp Pro Val Arg His Pro Ala Leu Lys Val Asn Ser Gln Arg 
            180                 185                 190         


Pro Phe Asn Ala Glu Pro Pro Pro Glu Leu Leu Thr Glu Asn Tyr Ile 
        195                 200                 205             


Thr Pro Asn Pro Ile Phe Phe Thr Arg Asn His Leu Pro Val Pro Asn 
    210                 215                 220                 


Leu Asp Pro Asp Thr Tyr Arg Leu His Val Val Gly Ala Pro Gly Gly 
225                 230                 235                 240 


Gln Ser Leu Ser Leu Ser Leu Asp Asp Leu His Asn Phe Pro Arg Tyr 
                245                 250                 255     


Glu Ile Thr Val Thr Leu Gln Cys Ala Gly Asn Arg Arg Ser Glu Met 
            260                 265                 270         


Thr Gln Val Lys Glu Val Lys Gly Leu Glu Trp Arg Thr Gly Ala Ile 
        275                 280                 285             


Ser Thr Ala Arg Trp Ala Gly Ala Arg Leu Cys Asp Val Leu Ala Gln 
    290                 295                 300                 


Ala Gly His Gln Leu Cys Glu Thr Glu Ala His Val Cys Phe Glu Gly 
305                 310                 315                 320 


Leu Asp Ser Asp Pro Thr Gly Thr Ala Tyr Gly Ala Ser Ile Pro Leu 
                325                 330                 335     


Ala Arg Ala Met Asp Pro Glu Ala Glu Val Leu Leu Ala Tyr Glu Met 
            340                 345                 350         


Asn Gly Gln Pro Leu Pro Arg Asp His Gly Phe Pro Val Arg Val Val 
        355                 360                 365             


Val Pro Gly Val Val Gly Ala Arg His Val Lys Trp Leu Gly Arg Val 
    370                 375                 380                 


Ser Val Gln Pro Glu Glu Ser Tyr Ser His Trp Gln Arg Arg Asp Tyr 
385                 390                 395                 400 


Lys Gly Phe Ser Pro Ser Val Asp Trp Glu Thr Val Asp Phe Asp Ser 
                405                 410                 415     


Ala Pro Ser Ile Gln Glu Leu Pro Val Gln Ser Ala Ile Thr Glu Pro 
            420                 425                 430         


Arg Asp Gly Glu Thr Val Glu Ser Gly Glu Val Thr Ile Lys Gly Tyr 
        435                 440                 445             


Ala Trp Ser Gly Gly Gly Arg Ala Val Ile Arg Val Asp Val Ser Leu 
    450                 455                 460                 


Asp Gly Gly Leu Thr Trp Gln Val Ala Lys Leu Asp Gly Glu Glu Gln 
465                 470                 475                 480 


Arg Pro Arg Lys Ala Trp Ala Trp Arg Leu Trp Gln Leu Lys Ala Pro 
                485                 490                 495     


Val Pro Ala Gly Gln Lys Glu Leu Asn Ile Val Cys Lys Ala Val Asp 
            500                 505                 510         


Asp Gly Tyr Asn Val Gln Pro Asp Thr Val Ala Pro Ile Trp Asn Leu 
        515                 520                 525             


Arg Gly Val Leu Ser Asn Ala Trp His Arg Val His Val Tyr Val Ser 
    530                 535                 540                 


Pro 
545 


<210>  45
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Glu Pro Pro Tyr Ser Leu Thr Ala His Tyr Asp Glu Phe Gln Glu 
1               5                   10                  15      


Val Lys Tyr Val Ser Arg Cys Gly Ala Gly Gly Ala Arg Gly Ala Ser 
            20                  25                  30          


Leu Pro Pro Gly Phe Pro Leu Gly Ala Ala Arg Ser Ala Thr Gly Ala 
        35                  40                  45              


Arg Ser Gly Leu Pro Arg Trp Asn Arg Arg Glu Val Cys Leu Leu Ser 
    50                  55                  60                  


Gly Leu Val Phe Ala Ala Gly Leu Cys Ala Ile Leu Ala Ala Met Leu 
65                  70                  75                  80  


Ala Leu Lys Tyr Leu Gly Pro Val Ala Ala Gly Gly Gly Ala Cys Pro 
                85                  90                  95      


Glu Gly Cys Pro Glu Arg Lys Ala Phe Ala Arg Ala Ala Arg Phe Leu 
            100                 105                 110         


Ala Ala Asn Leu Asp Ala Ser Ile Asp Pro Cys Gln Asp Phe Tyr Ser 
        115                 120                 125             


Phe Ala Cys Gly Gly Trp Leu Arg Arg His Ala Ile Pro Asp Asp Lys 
    130                 135                 140                 


Leu Thr Tyr Gly Thr Ile Ala Ala Ile Gly Glu Gln Asn Glu Glu Arg 
145                 150                 155                 160 


Leu Arg Arg Leu Leu Ala Arg Pro Gly Gly Gly Pro Gly Gly Ala Ala 
                165                 170                 175     


Gln Arg Lys Val Arg Ala Phe Phe Arg Ser Cys Leu Asp Met Arg Glu 
            180                 185                 190         


Ile Glu Arg Leu Gly Pro Arg Pro Met Leu Glu Val Ile Glu Asp Cys 
        195                 200                 205             


Gly Gly Trp Asp Leu Gly Gly Ala Glu Glu Arg Pro Gly Val Ala Ala 
    210                 215                 220                 


Arg Trp Asp Leu Asn Arg Leu Leu Tyr Lys Ala Gln Gly Val Tyr Ser 
225                 230                 235                 240 


Ala Ala Ala Leu Phe Ser Leu Thr Val Ser Leu Asp Asp Arg Asn Ser 
                245                 250                 255     


Ser Arg Tyr Val Ile Arg Ile Asp Gln Asp Gly Leu Thr Leu Pro Glu 
            260                 265                 270         


Arg Thr Leu Tyr Leu Ala Gln Asp Glu Asp Ser Glu Lys Ile Leu Ala 
        275                 280                 285             


Ala Tyr Arg Val Phe Met Glu Arg Val Leu Ser Leu Leu Gly Ala Asp 
    290                 295                 300                 


Ala Val Glu Gln Lys Ala Gln Glu Ile Leu Gln Val Glu Gln Gln Leu 
305                 310                 315                 320 


Ala Asn Ile Thr Val Ser Glu Tyr Asp Asp Leu Arg Arg Asp Val Ser 
                325                 330                 335     


Ser Met Tyr Asn Lys Val Thr Leu Gly Gln Leu Gln Lys Ile Thr Pro 
            340                 345                 350         


His Leu Arg Trp Lys Trp Leu Leu Asp Gln Ile Phe Gln Glu Asp Phe 
        355                 360                 365             


Ser Glu Glu Glu Glu Val Val Leu Leu Ala Thr Asp Tyr Met Gln Gln 
    370                 375                 380                 


Val Ser Gln Leu Ile Arg Ser Thr Pro His Arg Val Leu His Asn Tyr 
385                 390                 395                 400 


Leu Val Trp Arg Val Val Val Val Leu Ser Glu His Leu Ser Pro Pro 
                405                 410                 415     


Phe Arg Glu Ala Leu His Glu Leu Ala Gln Glu Met Glu Gly Ser Asp 
            420                 425                 430         


Lys Pro Gln Glu Leu Ala Arg Val Cys Leu Gly Gln Ala Asn Arg His 
        435                 440                 445             


Phe Gly Met Ala Leu Gly Ala Leu Phe Val His Glu His Phe Ser Ala 
    450                 455                 460                 


Ala Ser Lys Ala Lys Val Gln Gln Leu Val Glu Asp Ile Lys Tyr Ile 
465                 470                 475                 480 


Leu Gly Gln Arg Leu Glu Glu Leu Asp Trp Met Asp Ala Glu Thr Arg 
                485                 490                 495     


Ala Ala Ala Arg Ala Lys Leu Gln Tyr Met Met Val Met Val Gly Tyr 
            500                 505                 510         


Pro Asp Phe Leu Leu Lys Pro Asp Ala Val Asp Lys Glu Tyr Glu Phe 
        515                 520                 525             


Glu Val His Glu Lys Thr Tyr Phe Lys Asn Ile Leu Asn Ser Ile Arg 
    530                 535                 540                 


Phe Ser Ile Gln Leu Ser Val Lys Lys Ile Arg Gln Glu Val Asp Lys 
545                 550                 555                 560 


Ser Thr Trp Leu Leu Pro Pro Gln Ala Leu Asn Ala Tyr Tyr Leu Pro 
                565                 570                 575     


Asn Lys Asn Gln Met Val Phe Pro Ala Gly Ile Leu Gln Pro Thr Leu 
            580                 585                 590         


Tyr Asp Pro Asp Phe Pro Gln Ser Leu Asn Tyr Gly Gly Ile Gly Thr 
        595                 600                 605             


Ile Ile Gly His Glu Leu Thr His Gly Tyr Asp Asp Trp Gly Gly Gln 
    610                 615                 620                 


Tyr Asp Arg Ser Gly Asn Leu Leu His Trp Trp Thr Glu Ala Ser Tyr 
625                 630                 635                 640 


Ser Arg Phe Leu Arg Lys Ala Glu Cys Ile Val Arg Leu Tyr Asp Asn 
                645                 650                 655     


Phe Thr Val Tyr Asn Gln Arg Val Asn Gly Lys His Thr Leu Gly Glu 
            660                 665                 670         


Asn Ile Ala Asp Met Gly Gly Leu Lys Leu Ala Tyr His Ala Tyr Gln 
        675                 680                 685             


Lys Trp Val Arg Glu His Gly Pro Glu His Pro Leu Pro Arg Leu Lys 
    690                 695                 700                 


Tyr Thr His Asp Gln Leu Phe Phe Ile Ala Phe Ala Gln Asn Trp Cys 
705                 710                 715                 720 


Ile Lys Arg Arg Ser Gln Ser Ile Tyr Leu Gln Val Leu Thr Asp Lys 
                725                 730                 735     


His Ala Pro Glu His Tyr Arg Val Leu Gly Ser Val Ser Gln Phe Glu 
            740                 745                 750         


Glu Phe Gly Arg Ala Phe His Cys Pro Lys Asp Ser Pro Met Asn Pro 
        755                 760                 765             


Ala His Lys Cys Ser Val Trp 
    770                 775 


<210>  46
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Arg Thr Arg Glu Ala Gly Cys Val Ala Ala Gly Val Val Ile 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Val Tyr Arg Leu Ala Trp Gly Arg Asp 
            20                  25                  30          


Glu Asn Glu Lys Ile Trp Asp Glu Asp Glu Glu Ser Thr Asp Thr Ser 
        35                  40                  45              


Glu Ile Gly Val Glu Thr Val Lys Gly Ala Lys Thr Asn Ala Gly Ala 
    50                  55                  60                  


Gly Ser Gly Ala Lys Leu Gln Gly Asp Ser Glu Val Lys Pro Glu Val 
65                  70                  75                  80  


Ser Leu Gly Leu Glu Asp Cys Pro Gly Val Lys Glu Lys Ala His Ser 
                85                  90                  95      


Gly Ser His Ser Gly Gly Gly Leu Glu Ala Lys Ala Lys Ala Leu Phe 
            100                 105                 110         


Asn Thr Leu Lys Glu Gln Ala Ser Ala Lys Ala Gly Lys Gly Ala Arg 
        115                 120                 125             


Val Gly Thr Ile Ser Gly Asn Arg Thr Leu Ala Pro Ser Leu Pro Cys 
    130                 135                 140                 


Pro Gly Gly Arg Gly Gly Gly Cys His Pro Thr Arg Ser Gly Ser Arg 
145                 150                 155                 160 


Ala Gly Gly Arg Ala Ser Gly Lys Ser Lys Gly Lys Ala Arg Ser Lys 
                165                 170                 175     


Ser Thr Arg Ala Pro Ala Thr Thr Trp Pro Val Arg Arg Gly Lys Phe 
            180                 185                 190         


Asn Phe Pro Tyr Lys Ile Asp Asp Ile Leu Ser Ala Pro Asp Leu Gln 
        195                 200                 205             


Lys Val Leu Asn Ile Leu Glu Arg Thr Asn Asp Pro Phe Ile Gln Glu 
    210                 215                 220                 


Val Ala Leu Val Thr Leu Gly Asn Asn Ala Ala Tyr Ser Phe Asn Gln 
225                 230                 235                 240 


Asn Ala Ile Arg Glu Leu Gly Gly Val Pro Ile Ile Ala Lys Leu Ile 
                245                 250                 255     


Lys Thr Lys Asp Pro Ile Ile Arg Glu Lys Thr Tyr Asn Ala Leu Asn 
            260                 265                 270         


Asn Leu Ser Val Asn Ala Glu Asn Gln Gly Lys Ile Lys Thr Tyr Ile 
        275                 280                 285             


Ser Gln Val Cys Asp Asp Thr Met Val Cys Arg Leu Asp Ser Ala Val 
    290                 295                 300                 


Gln Met Ala Gly Leu Arg Leu Leu Thr Asn Met Thr Val Thr Asn His 
305                 310                 315                 320 


Tyr Gln His Leu Leu Ser Tyr Ser Phe Pro Asp Phe Phe Ala Leu Leu 
                325                 330                 335     


Phe Leu Gly Asn His Phe Thr Lys Ile Gln Ile Met Lys Leu Ile Ile 
            340                 345                 350         


Asn Phe Thr Glu Asn Pro Ala Met Thr Arg Glu Leu Val Ser Cys Lys 
        355                 360                 365             


Val Pro Ser Glu Leu Ile Ser Leu Phe Asn Lys Glu Trp Asp Arg Glu 
    370                 375                 380                 


Ile Leu Leu Asn Ile Leu Thr Leu Phe Glu Asn Ile Asn Asp Asn Ile 
385                 390                 395                 400 


Lys Asn Glu Gly Leu Ala Ser Ser Arg Lys Glu Phe Ser Arg Ser Ser 
                405                 410                 415     


Leu Phe Phe Leu Phe Lys Glu Ser Gly Val Cys Val Lys Lys Ile Lys 
            420                 425                 430         


Ala Leu Ala Asn His Asn Asp Leu Val Val Lys Val Lys Val Leu Lys 
        435                 440                 445             


Val Leu Thr Lys Leu 
    450             


<210>  47
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Glu Leu Arg Ser Gly Ser Val Gly Ser Gln Ala Val Ala Arg Arg 
1               5                   10                  15      


Met Asp Gly Asp Ser Arg Asp Gly Gly Gly Gly Lys Asp Ala Thr Gly 
            20                  25                  30          


Ser Glu Asp Tyr Glu Asn Leu Pro Thr Ser Ala Ser Val Ser Thr His 
        35                  40                  45              


Met Thr Ala Gly Ala Met Ala Gly Ile Leu Glu His Ser Val Met Tyr 
    50                  55                  60                  


Pro Val Asp Ser Val Lys Thr Arg Met Gln Ser Leu Ser Pro Asp Pro 
65                  70                  75                  80  


Lys Ala Gln Tyr Thr Ser Ile Tyr Gly Ala Leu Lys Lys Ile Met Arg 
                85                  90                  95      


Thr Glu Gly Phe Trp Arg Pro Leu Arg Gly Val Asn Val Met Ile Met 
            100                 105                 110         


Gly Ala Gly Pro Ala His Ala Met Tyr Phe Ala Cys Tyr Glu Asn Met 
        115                 120                 125             


Lys Arg Thr Leu Asn Asp Val Phe His His Gln Gly Asn Ser His Leu 
    130                 135                 140                 


Ala Asn Gly Ile Ala Gly Ser Met Ala Thr Leu Leu His Asp Ala Val 
145                 150                 155                 160 


Met Asn Pro Ala Glu Val Val Lys Gln Arg Leu Gln Met Tyr Asn Ser 
                165                 170                 175     


Gln His Arg Ser Ala Ile Ser Cys Ile Arg Thr Val Trp Arg Thr Glu 
            180                 185                 190         


Gly Leu Gly Ala Phe Tyr Arg Ser Tyr Thr Thr Gln Leu Thr Met Asn 
        195                 200                 205             


Ile Pro Phe Gln Ser Ile His Phe Ile Thr Tyr Glu Phe Leu Gln Glu 
    210                 215                 220                 


Gln Val Asn Pro His Arg Thr Tyr Asn Pro Gln Ser His Ile Ile Ser 
225                 230                 235                 240 


Gly Gly Leu Ala Gly Ala Leu Ala Ala Ala Ala Thr Thr Pro Leu Asp 
                245                 250                 255     


Val Cys Lys Thr Leu Leu Asn Thr Gln Glu Asn Val Ala Leu Ser Leu 
            260                 265                 270         


Ala Asn Ile Ser Gly Arg Leu Ser Gly Met Ala Asn Ala Phe Arg Thr 
        275                 280                 285             


Val Tyr Gln Leu Asn Gly Leu Ala Gly Tyr Phe Lys Gly Ile Gln Ala 
    290                 295                 300                 


Arg Val Ile Tyr Gln Met Pro Ser Thr Ala Ile Ser Trp Ser Val Tyr 
305                 310                 315                 320 


Glu Phe Phe Lys Tyr Phe Leu Thr Lys Arg Gln Leu Glu Asn Arg Ala 
                325                 330                 335     


Pro Tyr 
        


<210>  48
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Asp Phe Asn Met Lys Lys Leu Ala Ser Asp Ala Gly Ile Phe Phe 
1               5                   10                  15      


Thr Arg Ala Val Gln Phe Thr Glu Glu Lys Phe Gly Gln Ala Glu Lys 
            20                  25                  30          


Thr Glu Leu Asp Ala His Phe Glu Asn Leu Leu Ala Arg Ala Asp Ser 
        35                  40                  45              


Thr Lys Asn Trp Thr Glu Lys Ile Leu Arg Gln Thr Glu Val Leu Leu 
    50                  55                  60                  


Gln Pro Asn Pro Ser Ala Arg Val Glu Glu Phe Leu Tyr Glu Lys Leu 
65                  70                  75                  80  


Asp Arg Lys Val Pro Ser Arg Val Thr Asn Gly Glu Leu Leu Ala Gln 
                85                  90                  95      


Tyr Met Ala Asp Ala Ala Ser Glu Leu Gly Pro Thr Thr Pro Tyr Gly 
            100                 105                 110         


Lys Thr Leu Ile Lys Val Ala Glu Ala Glu Lys Gln Leu Gly Ala Ala 
        115                 120                 125             


Glu Arg Asp Phe Ile His Thr Ala Ser Ile Ser Phe Leu Thr Pro Leu 
    130                 135                 140                 


Arg Asn Phe Leu Glu Gly Asp Trp Lys Thr Ile Ser Lys Glu Arg Arg 
145                 150                 155                 160 


Leu Leu Gln Asn Arg Arg Leu Asp Leu Asp Ala Cys Lys Ala Arg Leu 
                165                 170                 175     


Lys Lys Ala Lys Ala Ala Glu Ala Lys Ala Thr Thr Val Pro Asp Phe 
            180                 185                 190         


Gln Glu Thr Arg Pro Arg Asn Tyr Ile Leu Ser Ala Ser Ala Ser Ala 
        195                 200                 205             


Leu Trp Asn Asp Glu Val Asp Lys Ala Glu Gln Glu Leu Arg Val Ala 
    210                 215                 220                 


Gln Thr Glu Phe Asp Arg Gln Ala Glu Val Thr Arg Leu Leu Leu Glu 
225                 230                 235                 240 


Gly Ile Ser Ser Thr His Val Asn His Leu Arg Cys Leu His Glu Phe 
                245                 250                 255     


Val Lys Ser Gln Thr Thr Tyr Tyr Ala Gln Cys Tyr Arg His Met Leu 
            260                 265                 270         


Asp Leu Gln Lys Gln Leu Gly Arg Phe Pro Gly Thr Phe Val Gly Thr 
        275                 280                 285             


Thr Glu Pro Ala Ser Pro Pro Leu Ser Ser Thr Ser Pro Thr Thr Ala 
    290                 295                 300                 


Ala Ala Thr Met Pro Val Val Pro Ser Val Ala Ser Leu Ala Pro Pro 
305                 310                 315                 320 


Gly Glu Ala Ser Leu Cys Leu Glu Glu Val Ala Pro Pro Ala Ser Gly 
                325                 330                 335     


Thr Arg Lys Ala Arg Val Leu Tyr Asp Tyr Glu Ala Ala Asp Ser Ser 
            340                 345                 350         


Glu Leu Ala Leu Leu Ala Asp Glu Leu Ile Thr Val Tyr Ser Leu Pro 
        355                 360                 365             


Gly Met Asp Pro Asp Trp Leu Ile Gly Glu Arg Gly Asn Lys Lys Gly 
    370                 375                 380                 


Lys Val Pro Val Thr Tyr Leu Glu Leu Leu Ser 
385                 390                 395 


<210>  49
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Asn Phe Ser Glu Val Phe Lys Leu Ser Ser Leu Leu Cys Lys Phe 
1               5                   10                  15      


Ser Pro Asp Gly Lys Tyr Leu Ala Ser Cys Val Gln Tyr Arg Leu Val 
            20                  25                  30          


Val Arg Asp Val Asn Thr Leu Gln Ile Leu Gln Leu Tyr Thr Cys Leu 
        35                  40                  45              


Asp Gln Ile Gln His Ile Glu Trp Ser Ala Asp Ser Leu Phe Ile Leu 
    50                  55                  60                  


Cys Ala Met Tyr Lys Arg Gly Leu Val Gln Val Trp Ser Leu Glu Gln 
65                  70                  75                  80  


Pro Glu Trp His Cys Lys Ile Asp Glu Gly Ser Ala Gly Leu Val Ala 
                85                  90                  95      


Ser Cys Trp Ser Pro Asp Gly Arg His Ile Leu Asn Thr Thr Glu Phe 
            100                 105                 110         


His Leu Arg Ile Thr Val Trp Ser Leu Cys Thr Lys Ser Val Ser Tyr 
        115                 120                 125             


Ile Lys Tyr Pro Lys Ala Cys Leu Gln Gly Ile Thr Phe Thr Arg Asp 
    130                 135                 140                 


Gly Arg Tyr Met Ala Leu Ala Glu Arg Arg Asp Cys Lys Asp Tyr Val 
145                 150                 155                 160 


Ser Ile Phe Val Cys Ser Asp Trp Gln Leu Leu Arg His Phe Asp Thr 
                165                 170                 175     


Asp Thr Gln Asp Leu Thr Gly Ile Glu Trp Ala Pro Asn Gly Cys Val 
            180                 185                 190         


Leu Ala Val Trp Asp Thr Cys Leu Glu Tyr Lys Ile Leu Leu Tyr Ser 
        195                 200                 205             


Leu Asp Gly Arg Leu Leu Ser Thr Tyr Ser Ala Tyr Glu Trp Ser Leu 
    210                 215                 220                 


Gly Ile Lys Ser Val Ala Trp Ser Pro Ser Ser Gln Phe Leu Ala Val 
225                 230                 235                 240 


Gly Ser Tyr Asp Gly Lys Val Arg Ile Leu Asn His Val Thr Trp Lys 
                245                 250                 255     


Met Ile Thr Glu Phe Gly His Pro Ala Ala Ile Asn Asp Pro Lys Ile 
            260                 265                 270         


Val Val Tyr Lys Glu Ala Glu Lys Ser Pro Gln Leu Gly Leu Gly Cys 
        275                 280                 285             


Leu Ser Phe Pro Pro Pro Arg Ala Gly Ala Gly Pro Leu Pro Ser Ser 
    290                 295                 300                 


Glu Ser Lys Tyr Glu Ile Ala Ser Val Pro Val Ser Leu Gln Thr Leu 
305                 310                 315                 320 


Lys Pro Val Thr Asp Arg Ala Asn Pro Lys Ile Gly Ile Gly Met Leu 
                325                 330                 335     


Ala Phe Ser Pro Asp Ser Tyr Phe Leu Ala Thr Arg Asn Asp Asn Ile 
            340                 345                 350         


Pro Asn Ala Val Trp Val Trp Asp Ile Gln Lys Leu Arg Leu Phe Ala 
        355                 360                 365             


Val Leu Glu Gln Leu Ser Pro Val Arg Ala Phe Gln Trp Asp Pro Gln 
    370                 375                 380                 


Gln Pro Arg Leu Ala Ile Cys Thr Gly Gly Ser Arg Leu Tyr Leu Trp 
385                 390                 395                 400 


Ser Pro Ala Gly Cys Met Ser Val Gln Val Pro Gly Glu Gly Asp Phe 
                405                 410                 415     


Ala Val Leu Ser Leu Cys Trp His Leu Ser Gly Asp Ser Met Ala Leu 
            420                 425                 430         


Leu Ser Lys Asp His Phe Cys Leu Cys Phe Leu Glu Thr Glu Ala Val 
        435                 440                 445             


Val Gly Thr Ala Cys Arg Gln Leu Gly Gly His Thr 
    450                 455                 460 


<210>  50
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Gln Lys Arg Pro Ala Cys Thr Leu Lys Pro Glu Cys Val Gln 
1               5                   10                  15      


Gln Leu Leu Val Cys Ser Gln Glu Ala Lys Lys Ser Ala Tyr Cys Pro 
            20                  25                  30          


Tyr Ser His Phe Pro Val Gly Ala Ala Leu Leu Thr Gln Glu Gly Arg 
        35                  40                  45              


Ile Phe Lys Gly Cys Asn Ile Glu Asn Ala Cys Tyr Pro Leu Gly Ile 
    50                  55                  60                  


Cys Ala Glu Arg Thr Ala Ile Gln Lys Ala Val Ser Glu Gly Tyr Lys 
65                  70                  75                  80  


Asp Phe Arg Ala Ile Ala Ile Ala Ser Asp Met Gln Asp Asp Phe Ile 
                85                  90                  95      


Ser Pro Cys Gly Ala Cys Arg Gln Val Met Arg Glu Phe Gly Thr Asn 
            100                 105                 110         


Trp Pro Val Tyr Met Thr Lys Pro Asp Gly Thr Tyr Ile Val Met Thr 
        115                 120                 125             


Val Gln Glu Leu Leu Pro Ser Ser Phe Gly Pro Glu Asp Leu Gln Lys 
    130                 135                 140                 


Thr Gln 
145     


<210>  51
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Met Leu Ile Pro Thr His His Phe Arg Asn Ile Glu Arg Lys Pro 
1               5                   10                  15      


Glu Tyr Leu Gln Pro Glu Lys Cys Val Pro Pro Pro Tyr Pro Gly Pro 
            20                  25                  30          


Val Gly Thr Met Trp Phe Ile Arg Asp Gly Cys Gly Ile Ala Cys Ala 
        35                  40                  45              


Ile Val Thr Trp Phe Leu Val Leu Tyr Ala Glu Phe Val Val Leu Phe 
    50                  55                  60                  


Val Met Leu Ile Pro Ser Arg Asp Tyr Val Tyr Ser Ile Ile Asn Gly 
65                  70                  75                  80  


Ile Val Phe Asn Leu Leu Ala Phe Leu Ala Leu Ala Ser His Cys Arg 
                85                  90                  95      


Ala Met Leu Thr Asp Pro Gly Ala Val Pro Lys Gly Asn Ala Thr Lys 
            100                 105                 110         


Glu Phe Ile Glu Ser Leu Gln Leu Lys Pro Gly Gln Val Val Tyr Lys 
        115                 120                 125             


Cys Pro Lys Cys Cys Ser Ile Lys Pro Asp Arg Ala His His Cys Ser 
    130                 135                 140                 


Val Cys Lys Arg Cys Ile Arg Lys Met Asp His His Cys Pro Trp Val 
145                 150                 155                 160 


Asn Asn Cys Val Gly Glu Asn Asn Gln Lys Tyr Phe Val Leu Phe Thr 
                165                 170                 175     


Met Tyr Ile Ala Leu Ile Ser Leu His Ala Leu Ile Met Val Gly Phe 
            180                 185                 190         


His Phe Leu His Cys Phe Glu Glu Asp Trp Thr Lys Cys Ser Ser Phe 
        195                 200                 205             


Ser Pro Pro Thr Thr Val Ile Leu Leu Ile Leu Leu Cys Phe Glu Gly 
    210                 215                 220                 


Leu Leu Phe Leu Ile Phe Thr Ser Val Met Phe Gly Thr Gln Val His 
225                 230                 235                 240 


Ser Ile Cys Thr Asp Glu Thr Gly Ile Glu Gln Leu Lys Lys Glu Glu 
                245                 250                 255     


Arg Arg Trp Ala Lys Lys Thr Lys Trp Met Asn Met Lys Ala Val Phe 
            260                 265                 270         


Gly His Pro Phe Ser Leu Gly Trp Ala Ser Pro Phe Ala Thr Pro Asp 
        275                 280                 285             


Gln Gly Lys Ala Asp Pro Tyr Gln Tyr Val Val 
    290                 295                 


<210>  52
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ser Val Ile Phe Phe Ala Cys Val Val Arg Val Arg Asp Gly Leu 
1               5                   10                  15      


Pro Leu Ser Ala Ser Thr Asp Phe Tyr His Thr Gln Asp Phe Leu Glu 
            20                  25                  30          


Trp Arg Arg Arg Leu Lys Ser Leu Ala Leu Arg Leu Ala Gln Tyr Pro 
        35                  40                  45              


Gly Arg Gly Ser Ala Glu Gly Cys Asp Phe Ser Ile His Phe Ser Ser 
    50                  55                  60                  


Phe Gly Asp Val Ala Cys Met Ala Ile Cys Ser Cys Gln Cys Pro Ala 
65                  70                  75                  80  


Ala Met Ala Phe Cys Phe Leu Glu Thr Leu Trp Trp Glu Phe Thr Ala 
                85                  90                  95      


Ser Tyr Asp Thr Thr Cys Ile Gly Leu Ala Ser Arg Pro Tyr Ala Phe 
            100                 105                 110         


Leu Glu Phe Asp Ser Ile Ile Gln Lys Val Lys Trp His Phe Asn Tyr 
        115                 120                 125             


Val Ser Ser Ser Gln Met Glu Cys Ser Leu Glu Lys Ile Gln Glu Glu 
    130                 135                 140                 


Leu Lys Leu Gln Pro Pro Ala Val Leu Thr Leu Glu Asp Thr Asp Val 
145                 150                 155                 160 


Ala Asn Gly Val Met Asn Gly His Thr Pro Met His Leu Glu Pro Ala 
                165                 170                 175     


Pro Asn Phe Arg Met Glu Pro Val Thr Ala Leu Gly Ile Leu Ser Leu 
            180                 185                 190         


Ile Leu Asn Ile Met Cys Ala Ala Leu Asn Leu Ile Arg Gly Val His 
        195                 200                 205             


Leu Ala Glu His Ser Leu Gln Val Ala His Glu Glu Ile Gly Asn Ile 
    210                 215                 220                 


Leu Ala Phe Leu Val Pro Phe Val Ala Cys Ile Phe Gln Asp Pro Arg 
225                 230                 235                 240 


Ser Trp Phe Cys Trp Leu Asp Gln Thr Ser 
                245                 250 


<210>  53
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
            180                 185                 190         


Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
        195                 200                 205             


Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
    210                 215                 220                 


Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
225                 230                 235                 240 


Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln 
                245                 250                 255     


Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala 
            260                 265                 270         


Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala 
        275                 280                 285             


Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser 
    290                 295                 300                 


Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met 
305                 310                 315                 320 


His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly 
                325                 330                 335     


Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr 
            340                 345                 350         


Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro 
        355                 360                 365             


Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala 
    370                 375                 380                 


Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg 
385                 390                 395                 400 


Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn 
                405                 410                 415     


Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His 
            420                 425                 430         


Ser Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala 
        435                 440                 445             


Val Trp Arg Pro Tyr 
    450             


<210>  54
<211>  1283
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Trp Gly Ser Asp Arg Leu Ala Gly Ala Gly Gly Gly Gly Ala Ala 
1               5                   10                  15      


Val Thr Val Ala Phe Thr Asn Ala Arg Asp Cys Phe Leu His Leu Pro 
            20                  25                  30          


Arg Arg Leu Val Ala Gln Leu His Leu Leu Gln Asn Gln Ala Ile Glu 
        35                  40                  45              


Val Val Trp Ser His Gln Pro Ala Phe Leu Ser Trp Val Glu Gly Arg 
    50                  55                  60                  


His Phe Ser Asp Gln Gly Glu Asn Val Ala Glu Ile Asn Arg Gln Val 
65                  70                  75                  80  


Gly Gln Lys Leu Gly Leu Ser Asn Gly Gly Gln Val Phe Leu Lys Pro 
                85                  90                  95      


Cys Ser His Val Val Ser Cys Gln Gln Val Glu Val Glu Pro Leu Ser 
            100                 105                 110         


Ala Asp Asp Trp Glu Ile Leu Glu Leu His Ala Val Ser Leu Glu Gln 
        115                 120                 125             


His Leu Leu Asp Gln Ile Arg Ile Val Phe Pro Lys Ala Ile Phe Pro 
    130                 135                 140                 


Val Trp Val Asp Gln Gln Thr Tyr Ile Phe Ile Gln Ile Val Ala Leu 
145                 150                 155                 160 


Ile Pro Ala Ala Ser Tyr Gly Arg Leu Glu Thr Asp Thr Lys Leu Leu 
                165                 170                 175     


Ile Gln Pro Lys Thr Arg Arg Ala Lys Glu Asn Thr Phe Ser Lys Ala 
            180                 185                 190         


Asp Ala Glu Tyr Lys Lys Leu His Ser Tyr Gly Arg Asp Gln Lys Gly 
        195                 200                 205             


Met Met Lys Glu Leu Gln Thr Lys Gln Leu Gln Ser Asn Thr Val Gly 
    210                 215                 220                 


Ile Thr Glu Ser Asn Glu Asn Glu Ser Glu Ile Pro Val Asp Ser Ser 
225                 230                 235                 240 


Ser Val Ala Ser Leu Trp Thr Met Ile Gly Ser Ile Phe Ser Phe Gln 
                245                 250                 255     


Ser Glu Lys Lys Gln Glu Thr Ser Trp Gly Leu Thr Glu Ile Asn Ala 
            260                 265                 270         


Phe Lys Asn Met Gln Ser Lys Val Val Pro Leu Asp Asn Ile Phe Arg 
        275                 280                 285             


Val Cys Lys Ser Gln Pro Pro Ser Ile Tyr Asn Ala Ser Ala Thr Ser 
    290                 295                 300                 


Val Phe His Lys His Cys Ala Ile His Val Phe Pro Trp Asp Gln Glu 
305                 310                 315                 320 


Tyr Phe Asp Val Glu Pro Ser Phe Thr Val Thr Tyr Gly Lys Leu Val 
                325                 330                 335     


Lys Leu Leu Ser Pro Lys Gln Gln Gln Ser Lys Thr Lys Gln Asn Val 
            340                 345                 350         


Leu Ser Pro Glu Lys Glu Lys Gln Met Ser Glu Pro Leu Asp Gln Lys 
        355                 360                 365             


Lys Ile Arg Ser Asp His Asn Glu Glu Asp Glu Lys Ala Cys Val Leu 
    370                 375                 380                 


Gln Val Val Trp Asn Gly Leu Glu Glu Leu Asn Asn Ala Ile Lys Tyr 
385                 390                 395                 400 


Thr Lys Asn Val Glu Val Leu His Leu Gly Lys Val Trp Ile Pro Asp 
                405                 410                 415     


Asp Leu Arg Lys Arg Leu Asn Ile Glu Met His Ala Val Val Arg Ile 
            420                 425                 430         


Thr Pro Val Glu Val Thr Pro Lys Ile Pro Arg Ser Leu Lys Leu Gln 
        435                 440                 445             


Pro Arg Glu Asn Leu Pro Lys Asp Ile Ser Glu Glu Asp Ile Lys Thr 
    450                 455                 460                 


Val Phe Tyr Ser Trp Leu Gln Gln Ser Thr Thr Thr Met Leu Pro Leu 
465                 470                 475                 480 


Val Ile Ser Glu Glu Glu Phe Ile Lys Leu Glu Thr Lys Asp Gly Leu 
                485                 490                 495     


Lys Glu Phe Ser Leu Ser Ile Val His Ser Trp Glu Lys Glu Lys Asp 
            500                 505                 510         


Lys Asn Ile Phe Leu Leu Ser Pro Asn Leu Leu Gln Lys Thr Thr Ile 
        515                 520                 525             


Gln Val Leu Leu Asp Pro Met Val Lys Glu Glu Asn Ser Glu Glu Ile 
    530                 535                 540                 


Asp Phe Ile Leu Pro Phe Leu Lys Leu Ser Ser Leu Gly Gly Val Asn 
545                 550                 555                 560 


Ser Leu Gly Val Ser Ser Leu Glu His Ile Thr His Ser Leu Leu Gly 
                565                 570                 575     


Arg Pro Leu Ser Arg Gln Leu Met Ser Leu Val Ala Gly Leu Arg Asn 
            580                 585                 590         


Gly Ala Leu Leu Leu Thr Gly Gly Lys Gly Ser Gly Lys Ser Thr Leu 
        595                 600                 605             


Ala Lys Ala Ile Cys Lys Glu Ala Phe Asp Lys Leu Asp Ala His Val 
    610                 615                 620                 


Glu Arg Val Asp Cys Lys Ala Leu Arg Gly Lys Arg Leu Glu Asn Ile 
625                 630                 635                 640 


Gln Lys Thr Leu Glu Val Ala Phe Ser Glu Ala Val Trp Met Gln Pro 
                645                 650                 655     


Ser Val Val Leu Leu Asp Asp Leu Asp Leu Ile Ala Gly Leu Pro Ala 
            660                 665                 670         


Val Pro Glu His Glu His Ser Pro Asp Ala Val Gln Ser Gln Arg Leu 
        675                 680                 685             


Ala His Ala Leu Asn Asp Met Ile Lys Glu Phe Ile Ser Met Gly Ser 
    690                 695                 700                 


Leu Val Ala Leu Ile Ala Thr Ser Gln Ser Gln Gln Ser Leu His Pro 
705                 710                 715                 720 


Leu Leu Val Ser Ala Gln Gly Val His Ile Phe Gln Cys Val Gln His 
                725                 730                 735     


Ile Gln Pro Pro Asn Gln Glu Gln Arg Cys Glu Ile Leu Cys Asn Val 
            740                 745                 750         


Ile Lys Asn Lys Leu Asp Cys Asp Ile Asn Lys Phe Thr Asp Leu Asp 
        755                 760                 765             


Leu Gln His Val Ala Lys Glu Thr Gly Gly Phe Val Ala Arg Asp Phe 
    770                 775                 780                 


Thr Val Leu Val Asp Arg Ala Ile His Ser Arg Leu Ser Arg Gln Ser 
785                 790                 795                 800 


Ile Ser Thr Arg Glu Lys Leu Val Leu Thr Thr Leu Asp Phe Gln Lys 
                805                 810                 815     


Ala Leu Arg Gly Phe Leu Pro Ala Ser Leu Arg Ser Val Asn Leu His 
            820                 825                 830         


Lys Pro Arg Asp Leu Gly Trp Asp Lys Ile Gly Gly Leu His Glu Val 
        835                 840                 845             


Arg Gln Ile Leu Met Asp Thr Ile Gln Leu Pro Ala Lys Tyr Pro Glu 
    850                 855                 860                 


Leu Phe Ala Asn Leu Pro Ile Arg Gln Arg Thr Gly Ile Leu Leu Tyr 
865                 870                 875                 880 


Gly Pro Pro Gly Thr Gly Lys Thr Leu Leu Ala Gly Val Ile Ala Arg 
                885                 890                 895     


Glu Ser Arg Met Asn Phe Ile Ser Val Lys Gly Pro Glu Leu Leu Ser 
            900                 905                 910         


Lys Tyr Ile Gly Ala Ser Glu Gln Ala Val Arg Asp Ile Phe Ile Arg 
        915                 920                 925             


Ala Gln Ala Ala Lys Pro Cys Ile Leu Phe Phe Asp Glu Phe Glu Ser 
    930                 935                 940                 


Ile Ala Pro Arg Arg Gly His Asp Asn Thr Gly Val Thr Asp Arg Val 
945                 950                 955                 960 


Val Asn Gln Leu Leu Thr Gln Leu Asp Gly Val Glu Gly Leu Gln Gly 
                965                 970                 975     


Val Tyr Val Leu Ala Ala Thr Ser Arg Pro Asp Leu Ile Asp Pro Ala 
            980                 985                 990         


Leu Leu Arg Pro Gly Arg Leu Asp  Lys Cys Val Tyr Cys  Pro Pro Pro 
        995                 1000                 1005             


Asp Gln  Val Ser Arg Leu Glu  Ile Leu Asn Val Leu  Ser Asp Ser 
    1010                 1015                 1020             


Leu Pro  Leu Ala Asp Asp Val  Asp Leu Gln His Val  Ala Ser Val 
    1025                 1030                 1035             


Thr Asp  Ser Phe Thr Gly Ala  Asp Leu Lys Ala Leu  Leu Tyr Asn 
    1040                 1045                 1050             


Ala Gln  Leu Glu Ala Leu His  Gly Met Leu Leu Ser  Ser Gly Leu 
    1055                 1060                 1065             


Gln Asp  Gly Ser Ser Ser Ser  Asp Ser Asp Leu Ser  Leu Ser Ser 
    1070                 1075                 1080             


Met Val  Phe Leu Asn His Ser  Ser Gly Ser Asp Asp  Ser Ala Gly 
    1085                 1090                 1095             


Asp Gly  Glu Cys Gly Leu Asp  Gln Ser Leu Val Ser  Leu Glu Met 
    1100                 1105                 1110             


Ser Glu  Ile Leu Pro Asp Glu  Ser Lys Phe Asn Met  Tyr Arg Leu 
    1115                 1120                 1125             


Tyr Phe  Gly Ser Ser Tyr Glu  Ser Glu Leu Gly Asn  Gly Thr Ser 
    1130                 1135                 1140             


Ser Asp  Leu Ser Ser Gln Cys  Leu Ser Ala Pro Ser  Ser Met Thr 
    1145                 1150                 1155             


Gln Asp  Leu Pro Gly Val Pro  Gly Lys Asp Gln Leu  Phe Ser Gln 
    1160                 1165                 1170             


Pro Pro  Val Leu Arg Thr Ala  Ser Gln Glu Gly Cys  Gln Glu Leu 
    1175                 1180                 1185             


Thr Gln  Glu Gln Arg Asp Gln  Leu Arg Ala Asp Ile  Ser Ile Ile 
    1190                 1195                 1200             


Lys Gly  Arg Tyr Arg Ser Gln  Ser Gly Glu Asp Glu  Ser Met Asn 
    1205                 1210                 1215             


Gln Pro  Gly Pro Ile Lys Thr  Arg Leu Ala Ile Ser  Gln Ser His 
    1220                 1225                 1230             


Leu Met  Thr Ala Leu Gly His  Thr Arg Pro Ser Ile  Ser Glu Asp 
    1235                 1240                 1245             


Asp Trp  Lys Asn Phe Ala Glu  Leu Tyr Glu Ser Phe  Gln Asn Pro 
    1250                 1255                 1260             


Lys Arg  Arg Lys Asn Gln Ser  Gly Thr Met Phe Arg  Pro Gly Gln 
    1265                 1270                 1275             


Lys Val  Thr Leu Ala 
    1280             


<210>  55
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Phe Arg Arg Pro Val Leu Gln Val Leu Arg Gln Phe Val Arg His 
1               5                   10                  15      


Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Ser Leu Asn Arg 
            20                  25                  30          


Val His Leu Leu Gly Arg Val Gly Gln Asp Pro Val Leu Arg Gln Val 
        35                  40                  45              


Glu Gly Lys Asn Pro Val Thr Ile Phe Ser Leu Ala Thr Asn Glu Met 
    50                  55                  60                  


Trp Arg Ser Gly Asp Ser Glu Val Tyr Gln Leu Gly Asp Val Ser Gln 
65                  70                  75                  80  


Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro Gly Leu Arg Asp 
                85                  90                  95      


Val Ala Tyr Gln Tyr Val Lys Lys Gly Ser Arg Ile Tyr Leu Glu Gly 
            100                 105                 110         


Lys Ile Asp Tyr Gly Glu Tyr Met Asp Lys Asn Asn Val Arg Arg Gln 
        115                 120                 125             


Ala Thr Thr Ile Ile Ala Asp Asn Ile Ile Phe Leu Ser Asp Gln Thr 
    130                 135                 140                 


Lys Glu Lys Glu 
145             


<210>  56
<211>  1476
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Thr Ser Ser Ser Pro Ala Gly Leu Glu Gly Ser Asp Leu Ser Ser 
1               5                   10                  15      


Ile Asn Thr Met Met Ser Ala Val Met Ser Val Gly Lys Val Thr Glu 
            20                  25                  30          


Asn Gly Gly Ser Pro Gln Gly Ile Lys Ser Pro Ser Lys Pro Pro Gly 
        35                  40                  45              


Pro Asn Arg Ile Gly Arg Arg Asn Gln Glu Thr Lys Glu Glu Lys Ser 
    50                  55                  60                  


Ser Tyr Asn Cys Pro Leu Cys Glu Lys Ile Cys Thr Thr Gln His Gln 
65                  70                  75                  80  


Leu Thr Met His Ile Arg Gln His Asn Thr Asp Thr Gly Gly Ala Asp 
                85                  90                  95      


His Ser Cys Ser Ile Cys Gly Lys Ser Leu Ser Ser Ala Ser Ser Leu 
            100                 105                 110         


Asp Arg His Met Leu Val His Ser Gly Glu Arg Pro Tyr Lys Cys Thr 
        115                 120                 125             


Val Cys Gly Gln Ser Phe Thr Thr Asn Gly Asn Met His Arg His Met 
    130                 135                 140                 


Lys Ile His Glu Lys Asp Pro Asn Ser Ala Thr Ala Thr Ala Pro Pro 
145                 150                 155                 160 


Ser Pro Leu Lys Arg Arg Arg Leu Ser Ser Lys Arg Lys Leu Ser His 
                165                 170                 175     


Asp Ala Glu Ser Glu Arg Glu Asp Pro Ala Pro Ala Lys Lys Met Val 
            180                 185                 190         


Glu Asp Gly Gln Ser Gly Asp Leu Glu Lys Lys Ala Asp Glu Val Phe 
        195                 200                 205             


His Cys Pro Val Cys Phe Lys Glu Phe Val Cys Lys Tyr Gly Leu Glu 
    210                 215                 220                 


Thr His Met Glu Thr His Ser Asp Asn Pro Leu Arg Cys Asp Ile Cys 
225                 230                 235                 240 


Cys Val Thr Phe Arg Thr His Arg Gly Leu Leu Arg His Asn Ala Leu 
                245                 250                 255     


Val His Lys Gln Leu Pro Arg Asp Ala Met Gly Arg Pro Phe Ile Gln 
            260                 265                 270         


Asn Asn Pro Ser Ile Pro Ala Gly Phe His Asp Leu Gly Phe Thr Asp 
        275                 280                 285             


Phe Ser Cys Arg Lys Phe Pro Arg Ile Ser Gln Ala Trp Cys Glu Thr 
    290                 295                 300                 


Asn Leu Arg Arg Cys Ile Ser Glu Gln His Arg Phe Val Cys Asp Thr 
305                 310                 315                 320 


Cys Asp Lys Ala Phe Pro Met Leu Cys Ser Leu Ala Leu His Lys Gln 
                325                 330                 335     


Thr His Val Ala Ala Asp Gln Gly Gln Glu Lys Pro Gln Ala Thr Pro 
            340                 345                 350         


Leu Pro Gly Asp Ala Leu Asp Gln Lys Gly Phe Leu Ala Leu Leu Gly 
        355                 360                 365             


Leu Gln His Thr Lys Asp Val Arg Pro Ala Pro Ala Glu Glu Pro Leu 
    370                 375                 380                 


Pro Asp Asp Asn Gln Ala Ile Gln Leu Gln Thr Leu Lys Cys Gln Leu 
385                 390                 395                 400 


Pro Gln Asp Pro Gly Cys Thr Asn Leu Leu Ser Leu Ser Pro Phe Glu 
                405                 410                 415     


Ala Ala Ser Leu Gly Gly Ser Leu Thr Val Leu Pro Ala Thr Lys Asp 
            420                 425                 430         


Ser Ile Lys His Leu Ser Leu Gln Pro Phe Gln Lys Gly Phe Ile Ile 
        435                 440                 445             


Gln Pro Asp Ser Ser Ile Val Val Lys Pro Ile Ser Gly Glu Ser Ala 
    450                 455                 460                 


Ile Glu Leu Ala Asp Ile Gln Gln Ile Leu Lys Met Ala Ala Ser Ala 
465                 470                 475                 480 


Pro Pro Gln Ile Ser Leu Pro Pro Phe Ser Lys Ala Pro Ala Ala Pro 
                485                 490                 495     


Leu Gln Ala Ile Phe Lys His Met Pro Pro Leu Lys Pro Lys Pro Leu 
            500                 505                 510         


Val Thr Pro Arg Thr Val Val Ala Thr Ser Thr Pro Pro Pro Leu Ile 
        515                 520                 525             


Asn Ala Gln Gln Ala Ser Pro Gly Cys Ile Ser Pro Ser Leu Pro Pro 
    530                 535                 540                 


Pro Pro Leu Lys Leu Leu Lys Gly Ser Val Glu Ala Ala Ser Asn Ala 
545                 550                 555                 560 


His Leu Leu Gln Ser Lys Ser Gly Thr Gln Pro His Ala Ala Thr Arg 
                565                 570                 575     


Leu Ser Leu Gln Gln Pro Arg Ala Glu Leu Pro Gly Gln Pro Glu Met 
            580                 585                 590         


Lys Thr Gln Leu Glu Gln Asp Ser Ile Ile Glu Ala Leu Leu Pro Leu 
        595                 600                 605             


Ser Met Glu Ala Lys Ile Lys Gln Glu Ile Thr Glu Gly Glu Leu Lys 
    610                 615                 620                 


Ala Phe Met Thr Ala Pro Gly Gly Lys Lys Thr Pro Ala Met Arg Lys 
625                 630                 635                 640 


Val Leu Tyr Pro Cys Arg Phe Cys Asn Gln Val Phe Ala Phe Ser Gly 
                645                 650                 655     


Val Leu Arg Ala His Val Arg Ser His Leu Gly Ile Ser Pro Tyr Gln 
            660                 665                 670         


Cys Asn Ile Cys Asp Tyr Ile Ala Ala Asp Lys Ala Ala Leu Ile Arg 
        675                 680                 685             


His Leu Arg Thr His Ser Gly Glu Arg Pro Tyr Ile Cys Lys Ile Cys 
    690                 695                 700                 


His Tyr Pro Phe Thr Val Lys Ala Asn Cys Glu Arg His Leu Arg Lys 
705                 710                 715                 720 


Lys His Leu Lys Ala Thr Arg Lys Asp Ile Glu Lys Asn Ile Glu Tyr 
                725                 730                 735     


Val Ser Ser Ser Ala Ala Glu Leu Val Asp Ala Phe Cys Ala Pro Asp 
            740                 745                 750         


Thr Val Cys Arg Leu Cys Gly Glu Asp Leu Lys His Tyr Arg Ala Leu 
        755                 760                 765             


Arg Ile His Met Arg Thr His Cys Gly Arg Gly Leu Gly Gly Gly His 
    770                 775                 780                 


Lys Gly Arg Lys Pro Phe Glu Cys Lys Glu Cys Ser Ala Ala Phe Ala 
785                 790                 795                 800 


Ala Lys Arg Asn Cys Ile His His Ile Leu Lys Gln His Leu His Val 
                805                 810                 815     


Pro Glu Gln Asp Ile Glu Ser Tyr Val Leu Ala Ala Asp Gly Leu Gly 
            820                 825                 830         


Pro Ala Glu Ala Pro Ala Ala Glu Ala Ser Gly Arg Gly Glu Asp Ser 
        835                 840                 845             


Gly Cys Ala Ala Leu Gly Asp Cys Lys Pro Leu Thr Ala Phe Leu Glu 
    850                 855                 860                 


Pro Gln Asn Gly Phe Leu His Arg Gly Pro Thr Gln Pro Pro Pro Pro 
865                 870                 875                 880 


His Val Ser Ile Lys Leu Glu Pro Ala Ser Ser Phe Ala Val Asp Phe 
                885                 890                 895     


Asn Glu Pro Leu Asp Phe Ser Gln Lys Gly Leu Ala Leu Val Gln Val 
            900                 905                 910         


Lys Gln Glu Asn Ile Ser Phe Leu Ser Pro Ser Ser Leu Val Pro Tyr 
        915                 920                 925             


Asp Cys Ser Met Glu Pro Ile Asp Leu Ser Ile Pro Lys Asn Phe Arg 
    930                 935                 940                 


Lys Gly Asp Lys Asp Leu Ala Thr Pro Ser Glu Ala Lys Lys Pro Glu 
945                 950                 955                 960 


Glu Glu Ala Gly Ser Ser Glu Gln Pro Ser Pro Cys Pro Ala Pro Gly 
                965                 970                 975     


Pro Ser Leu Pro Val Thr Leu Gly Pro Ser Gly Ile Leu Glu Ser Pro 
            980                 985                 990         


Met Ala Pro Ala Pro Ala Ala Thr  Pro Glu Pro Pro Ala  Gln Pro Leu 
        995                 1000                 1005             


Gln Gly  Pro Val Gln Leu Ala  Val Pro Ile Tyr Ser  Ser Ala Leu 
    1010                 1015                 1020             


Val Ser  Ser Pro Pro Leu Val  Gly Ser Ser Ala Leu  Leu Ser Gly 
    1025                 1030                 1035             


Thr Ala  Leu Leu Arg Pro Leu  Arg Pro Lys Pro Pro  Leu Leu Leu 
    1040                 1045                 1050             


Pro Lys  Pro Pro Val Thr Glu  Glu Leu Pro Pro Leu  Ala Ser Ile 
    1055                 1060                 1065             


Ala Gln  Ile Ile Ser Ser Val  Ser Ser Ala Pro Thr  Leu Leu Lys 
    1070                 1075                 1080             


Thr Lys  Val Ala Asp Pro Gly  Pro Ala Ser Thr Gly  Ser Asn Thr 
    1085                 1090                 1095             


Thr Ala  Ser Asp Ser Leu Gly  Gly Ser Val Pro Lys  Ala Ala Thr 
    1100                 1105                 1110             


Thr Ala  Thr Pro Ala Ala Thr  Thr Ser Pro Lys Glu  Ser Ser Glu 
    1115                 1120                 1125             


Pro Pro  Ala Pro Ala Ser Ser  Pro Glu Ala Ala Ser  Pro Thr Glu 
    1130                 1135                 1140             


Gln Gly  Pro Ala Gly Thr Ser  Lys Lys Arg Gly Arg  Lys Arg Gly 
    1145                 1150                 1155             


Met Arg  Ser Arg Pro Arg Ala  Asn Ser Gly Gly Val  Asp Leu Asp 
    1160                 1165                 1170             


Ser Ser  Gly Glu Phe Ala Ser  Ile Glu Lys Met Leu  Ala Thr Thr 
    1175                 1180                 1185             


Asp Thr  Asn Lys Phe Ser Pro  Phe Leu Gln Thr Ala  Glu Asp Asn 
    1190                 1195                 1200             


Thr Gln  Asp Glu Val Ala Gly  Ala Pro Ala Asp His  His Gly Pro 
    1205                 1210                 1215             


Ser Asp  Glu Glu Gln Gly Ser  Pro Pro Glu Asp Lys  Leu Leu Arg 
    1220                 1225                 1230             


Ala Lys  Arg Asn Ser Tyr Thr  Asn Cys Leu Gln Lys  Ile Thr Cys 
    1235                 1240                 1245             


Pro His  Cys Pro Arg Val Phe  Pro Trp Ala Ser Ser  Leu Gln Arg 
    1250                 1255                 1260             


His Met  Leu Thr His Thr Gly  Gln Lys Pro Phe Pro  Cys Gln Lys 
    1265                 1270                 1275             


Cys Asp  Ala Phe Phe Ser Thr  Lys Ser Asn Cys Glu  Arg His Gln 
    1280                 1285                 1290             


Leu Arg  Lys His Gly Val Thr  Thr Cys Ser Leu Arg  Arg Asn Gly 
    1295                 1300                 1305             


Leu Ile  Pro Gln Ser Lys Glu  Ser Asp Val Gly Ser  His Asp Ser 
    1310                 1315                 1320             


Thr Gly  Glu Arg Pro Tyr Lys  Cys Gln Thr Cys Glu  Arg Thr Phe 
    1325                 1330                 1335             


Thr Leu  Lys His Ser Leu Val  Arg His Gln Arg Ile  His Gln Lys 
    1340                 1345                 1350             


Ala Arg  His Ala Lys His His  Gly Lys Asp Ser Asp  Lys Glu Glu 
    1355                 1360                 1365             


Arg Gly  Glu Glu Asp Ser Glu  Asn Glu Ser Thr His  Ser Gly Asn 
    1370                 1375                 1380             


Asn Ala  Val Ser Glu Asn Glu  Ala Glu Leu Ala Pro  Asn Ala Ser 
    1385                 1390                 1395             


Asn His  Met Ala Val Thr Arg  Ser Arg Lys Glu Gly  Leu Ala Ser 
    1400                 1405                 1410             


Ala Thr  Lys Asp Cys Ser His  Arg Glu Glu Lys Val  Thr Ala Gly 
    1415                 1420                 1425             


Trp Pro  Ser Glu Pro Gly Gln  Gly Asp Leu Asn Pro  Glu Ser Pro 
    1430                 1435                 1440             


Ala Ala  Leu Gly Gln Asp Leu  Leu Glu Pro Arg Ser  Lys Arg Pro 
    1445                 1450                 1455             


Ala His  Pro Ile Leu Ala Thr  Ala Asp Gly Ala Ser  Gln Leu Val 
    1460                 1465                 1470             


Gly Met  Glu 
    1475     


<210>  57
<211>  1749
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ser Asp Thr Lys Val Lys Val Ala Val Arg Val Arg Pro Met Asn 
1               5                   10                  15      


Arg Arg Glu Leu Glu Leu Asn Thr Lys Cys Val Val Glu Met Glu Gly 
            20                  25                  30          


Asn Gln Thr Val Leu His Pro Pro Pro Ser Asn Thr Lys Gln Gly Glu 
        35                  40                  45              


Arg Lys Pro Pro Lys Val Phe Ala Phe Asp Tyr Cys Phe Trp Ser Met 
    50                  55                  60                  


Asp Glu Ser Asn Thr Thr Lys Tyr Ala Gly Gln Glu Val Val Phe Lys 
65                  70                  75                  80  


Cys Leu Gly Glu Gly Ile Leu Glu Lys Ala Phe Gln Gly Tyr Asn Ala 
                85                  90                  95      


Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Ser Phe Ser Met 
            100                 105                 110         


Met Gly His Ala Glu Gln Leu Gly Leu Ile Pro Arg Leu Cys Cys Ala 
        115                 120                 125             


Leu Phe Lys Arg Ile Ser Leu Glu Gln Asn Glu Ser Gln Thr Phe Lys 
    130                 135                 140                 


Val Glu Val Ser Tyr Met Glu Ile Tyr Asn Glu Lys Val Arg Asp Leu 
145                 150                 155                 160 


Leu Asp Pro Lys Gly Ser Arg Gln Ser Leu Lys Val Arg Glu His Lys 
                165                 170                 175     


Val Leu Gly Pro Tyr Val Asp Gly Leu Ser Gln Leu Ala Val Thr Ser 
            180                 185                 190         


Phe Glu Asp Ile Glu Ser Leu Met Ser Glu Gly Asn Lys Ser Arg Thr 
        195                 200                 205             


Val Ala Ala Thr Asn Met Asn Glu Glu Ser Ser Arg Ser His Ala Val 
    210                 215                 220                 


Phe Asn Ile Ile Ile Thr Gln Thr Leu Tyr Asp Leu Gln Ser Gly Asn 
225                 230                 235                 240 


Ser Gly Glu Lys Val Ser Lys Val Ser Leu Val Asp Leu Ala Gly Ser 
                245                 250                 255     


Glu Arg Val Ser Lys Thr Gly Ala Ala Gly Glu Arg Leu Lys Glu Gly 
            260                 265                 270         


Ser Asn Ile Asn Lys Ser Leu Thr Thr Leu Gly Leu Val Ile Ser Ser 
        275                 280                 285             


Leu Ala Asp Gln Ala Ala Gly Lys Gly Lys Ser Lys Phe Val Pro Tyr 
    290                 295                 300                 


Arg Asp Ser Val Leu Thr Trp Leu Leu Lys Asp Asn Leu Gly Gly Asn 
305                 310                 315                 320 


Ser Gln Thr Ser Met Ile Ala Thr Ile Ser Pro Ala Ala Asp Asn Tyr 
                325                 330                 335     


Glu Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys Arg Ile 
            340                 345                 350         


Val Asn His Ala Val Val Asn Glu Asp Pro Asn Ala Lys Val Ile Arg 
        355                 360                 365             


Glu Leu Arg Glu Glu Val Glu Lys Leu Arg Glu Gln Leu Ser Gln Ala 
    370                 375                 380                 


Glu Ala Met Lys Ala Pro Glu Leu Lys Glu Lys Leu Glu Glu Ser Glu 
385                 390                 395                 400 


Lys Leu Ile Lys Glu Leu Thr Val Thr Trp Glu Glu Lys Leu Arg Lys 
                405                 410                 415     


Thr Glu Glu Ile Ala Gln Glu Arg Gln Arg Gln Leu Glu Ser Met Gly 
            420                 425                 430         


Ile Ser Leu Glu Met Ser Gly Ile Lys Val Gly Asp Asp Lys Cys Tyr 
        435                 440                 445             


Leu Val Asn Leu Asn Ala Asp Pro Ala Leu Asn Glu Leu Leu Val Tyr 
    450                 455                 460                 


Tyr Leu Lys Asp His Thr Arg Val Gly Ala Asp Thr Ser Gln Asp Ile 
465                 470                 475                 480 


Gln Leu Phe Gly Ile Gly Ile Gln Pro Gln His Cys Glu Ile Asp Ile 
                485                 490                 495     


Ala Ser Asp Gly Asp Val Thr Leu Thr Pro Lys Glu Asn Ala Arg Ser 
            500                 505                 510         


Cys Val Asn Gly Thr Leu Val Cys Ser Thr Thr Gln Leu Trp His Gly 
        515                 520                 525             


Asp Arg Ile Leu Trp Gly Asn Asn His Phe Phe Arg Ile Asn Leu Pro 
    530                 535                 540                 


Lys Arg Lys Arg Arg Asp Trp Leu Lys Asp Phe Glu Lys Glu Thr Gly 
545                 550                 555                 560 


Pro Pro Glu His Asp Leu Asp Ala Ala Ser Glu Ala Ser Ser Glu Pro 
                565                 570                 575     


Asp Tyr Asn Tyr Glu Phe Ala Gln Met Glu Val Ile Met Lys Thr Leu 
            580                 585                 590         


Asn Ser Asn Asp Pro Val Gln Asn Val Val Gln Val Leu Glu Lys Gln 
        595                 600                 605             


Tyr Leu Glu Glu Lys Arg Ser Ala Leu Glu Glu Gln Arg Leu Met Tyr 
    610                 615                 620                 


Glu Arg Glu Leu Glu Gln Leu Arg Gln Gln Leu Ser Pro Asp Arg Gln 
625                 630                 635                 640 


Pro Gln Ser Ser Gly Pro Asp Arg Leu Ala Tyr Ser Ser Gln Thr Ala 
                645                 650                 655     


Gln Gln Lys Val Thr Gln Trp Ala Glu Glu Arg Asp Glu Leu Phe Arg 
            660                 665                 670         


Gln Ser Leu Ala Lys Leu Arg Glu Gln Leu Val Lys Ala Asn Thr Leu 
        675                 680                 685             


Val Arg Glu Ala Asn Phe Leu Ala Glu Glu Met Ser Lys Leu Thr Asp 
    690                 695                 700                 


Tyr Gln Val Thr Leu Gln Ile Pro Ala Ala Asn Leu Ser Ala Asn Arg 
705                 710                 715                 720 


Lys Arg Gly Ala Ile Val Ser Glu Pro Ala Ile Gln Val Arg Arg Lys 
                725                 730                 735     


Gly Lys Ser Thr Gln Val Trp Thr Ile Glu Lys Leu Glu Asn Lys Leu 
            740                 745                 750         


Ile Asp Met Arg Asp Leu Tyr Gln Glu Trp Lys Glu Lys Val Pro Glu 
        755                 760                 765             


Ala Lys Arg Leu Tyr Gly Lys Arg Gly Asp Pro Phe Tyr Glu Ala Gln 
    770                 775                 780                 


Glu Asn His Asn Leu Ile Gly Val Ala Asn Val Phe Leu Glu Cys Leu 
785                 790                 795                 800 


Phe Cys Asp Val Lys Leu Gln Tyr Ala Val Pro Ile Ile Ser Gln Gln 
                805                 810                 815     


Gly Glu Val Ala Gly Arg Leu His Val Glu Val Met Arg Val Thr Gly 
            820                 825                 830         


Ala Val Pro Glu Arg Val Val Glu Asp Asp Ser Ser Glu Asn Ser Ser 
        835                 840                 845             


Glu Ser Gly Ser Leu Glu Val Val Asp Ser Ser Gly Glu Ile Ile His 
    850                 855                 860                 


Arg Val Lys Lys Leu Thr Cys Arg Val Lys Ile Lys Glu Ala Thr Gly 
865                 870                 875                 880 


Leu Pro Leu Asn Leu Ser Asn Phe Val Phe Cys Gln Tyr Thr Phe Trp 
                885                 890                 895     


Asp Gln Cys Glu Ser Thr Val Ala Ala Pro Val Val Asp Pro Glu Val 
            900                 905                 910         


Pro Ser Pro Gln Ser Lys Asp Ala Gln Tyr Thr Val Thr Phe Ser His 
        915                 920                 925             


Cys Lys Asp Tyr Val Val Asn Val Thr Glu Glu Phe Leu Glu Phe Ile 
    930                 935                 940                 


Ser Asp Gly Ala Leu Ala Ile Glu Val Trp Gly His Arg Cys Ala Gly 
945                 950                 955                 960 


Asn Gly Ser Ser Ile Trp Glu Val Asp Ser Leu His Ala Lys Thr Arg 
                965                 970                 975     


Thr Leu His Asp Arg Trp Asn Glu Val Thr Arg Arg Ile Glu Met Trp 
            980                 985                 990         


Ile Ser Ile Leu Glu Leu Asn Glu  Leu Gly Glu Tyr Ala  Ala Val Glu 
        995                 1000                 1005             


Leu His  Gln Ala Lys Asp Val  Asn Thr Gly Gly Ile  Phe Gln Leu 
    1010                 1015                 1020             


Arg Gln  Gly His Ser Arg Arg  Val Gln Val Thr Val  Lys Pro Val 
    1025                 1030                 1035             


Gln His  Ser Gly Thr Leu Pro  Leu Met Val Glu Ala  Ile Leu Ser 
    1040                 1045                 1050             


Val Ser  Ile Gly Cys Val Thr  Ala Arg Ser Thr Lys  Leu Gln Arg 
    1055                 1060                 1065             


Gly Leu  Asp Ser Tyr Gln Glu  Glu Asp Leu Asn Cys  Val Arg Glu 
    1070                 1075                 1080             


Arg Trp  Ser Asp Ala Leu Ile  Lys Arg Arg Glu Tyr  Leu Asp Glu 
    1085                 1090                 1095             


Gln Ile  Lys Lys Val Ser Asn  Lys Thr Glu Lys Thr  Glu Asp Asp 
    1100                 1105                 1110             


Val Glu  Arg Glu Ala Gln Leu  Val Glu Gln Trp Val  Gly Leu Thr 
    1115                 1120                 1125             


Glu Glu  Arg Asn Ala Val Leu  Val Pro Ala Pro Gly  Ser Gly Ile 
    1130                 1135                 1140             


Pro Gly  Ala Pro Ala Asp Trp  Ile Pro Pro Pro Gly  Met Glu Thr 
    1145                 1150                 1155             


His Ile  Pro Val Leu Phe Leu  Asp Leu Asn Ala Asp  Asp Leu Ser 
    1160                 1165                 1170             


Ala Asn  Glu Gln Leu Val Gly  Pro His Ala Ser Gly  Val Asn Ser 
    1175                 1180                 1185             


Ile Leu  Pro Lys Glu His Gly  Ser Gln Phe Phe Tyr  Leu Pro Ile 
    1190                 1195                 1200             


Ile Lys  His Ser Asp Asp Glu  Val Ser Ala Thr Ala  Ser Trp Asp 
    1205                 1210                 1215             


Ser Ser  Val His Asp Ser Val  His Leu Asn Arg Val  Thr Pro Gln 
    1220                 1225                 1230             


Asn Glu  Arg Ile Tyr Leu Ile  Val Lys Thr Thr Val  Gln Leu Ser 
    1235                 1240                 1245             


His Pro  Ala Ala Met Glu Leu  Val Leu Arg Lys Arg  Ile Ala Ala 
    1250                 1255                 1260             


Asn Ile  Tyr Asn Lys Gln Ser  Phe Thr Gln Ser Leu  Lys Arg Arg 
    1265                 1270                 1275             


Ile Ser  Leu Lys Asn Ile Phe  Tyr Ser Cys Gly Val  Thr Tyr Glu 
    1280                 1285                 1290             


Ile Val  Ser Asn Ile Pro Lys  Ala Thr Glu Glu Ile  Glu Asp Arg 
    1295                 1300                 1305             


Glu Thr  Leu Ala Leu Leu Ala  Ala Arg Ser Glu Asn  Glu Gly Thr 
    1310                 1315                 1320             


Ser Asp  Gly Glu Thr Tyr Ile  Glu Lys Tyr Thr Arg  Gly Val Leu 
    1325                 1330                 1335             


Gln Val  Glu Asn Ile Leu Ser  Leu Glu Arg Leu Arg  Gln Ala Val 
    1340                 1345                 1350             


Thr Val  Lys Glu Ala Leu Ser  Thr Lys Ala Arg His  Ile Arg Arg 
    1355                 1360                 1365             


Ser Leu  Ser Thr Pro Asn Val  His Asn Val Ser Ser  Ser Arg Pro 
    1370                 1375                 1380             


Asp Leu  Ser Gly Phe Asp Glu  Asp Asp Lys Gly Trp  Pro Glu Asn 
    1385                 1390                 1395             


Gln Leu  Asp Met Ser Asp Tyr  Ser Ser Ser Tyr Gln  Asp Val Ala 
    1400                 1405                 1410             


Cys Tyr  Gly Thr Leu Pro Arg  Asp Ser Pro Arg Arg  Asn Lys Glu 
    1415                 1420                 1425             


Gly Cys  Thr Ser Glu Thr Pro  His Ala Leu Thr Val  Ser Pro Phe 
    1430                 1435                 1440             


Lys Ala  Phe Ser Pro Gln Pro  Pro Lys Phe Phe Lys  Pro Leu Met 
    1445                 1450                 1455             


Pro Val  Lys Glu Glu His Lys  Lys Arg Ile Ala Leu  Glu Ala Arg 
    1460                 1465                 1470             


Pro Leu  Leu Ser Gln Glu Asp  Ser Glu Glu Glu Glu  Asn Glu Leu 
    1475                 1480                 1485             


Glu Ala  Ile Asn Arg Lys Leu  Ile Ser Ser Gln Pro  Tyr Val Pro 
    1490                 1495                 1500             


Val Glu  Phe Ala Asp Phe Ser  Val Tyr Asn Ala Ser  Leu Glu Asn 
    1505                 1510                 1515             


Arg Glu  Trp Phe Ser Ser Lys  Val Asp Leu Ser Asn  Ser Arg Val 
    1520                 1525                 1530             


Leu Glu  Lys Glu Val Ser Arg  Ser Pro Thr Thr Ser  Ser Ile Thr 
    1535                 1540                 1545             


Ser Gly  Tyr Phe Ser His Ser  Ala Ser Asn Ala Thr  Leu Ser Asp 
    1550                 1555                 1560             


Met Val  Val Pro Ser Ser Asp  Ser Ser Asp Gln Leu  Ala Ile Gln 
    1565                 1570                 1575             


Thr Lys  Asp Ala Asp Ser Thr  Glu His Ser Thr Pro  Ser Leu Val 
    1580                 1585                 1590             


His Asp  Phe Arg Pro Ser Ser  Asn Lys Glu Leu Thr  Glu Val Glu 
    1595                 1600                 1605             


Lys Gly  Leu Val Lys Asp Lys  Ile Ile Val Val Pro  Leu Lys Glu 
    1610                 1615                 1620             


Asn Ser  Ala Leu Ala Lys Gly  Ser Pro Ser Ser Gln  Ser Ile Pro 
    1625                 1630                 1635             


Glu Lys  Asn Ser Lys Ser Leu  Cys Arg Thr Gly Ser  Cys Ser Glu 
    1640                 1645                 1650             


Leu Asp  Ala Cys Pro Ser Lys  Ile Ser Gln Pro Ala  Arg Gly Phe 
    1655                 1660                 1665             


Cys Pro  Arg Glu Val Thr Val  Glu His Thr Thr Asn  Ile Leu Glu 
    1670                 1675                 1680             


Asp His  Ser Phe Thr Glu Phe  Met Gly Val Ser Glu  Gly Lys Asp 
    1685                 1690                 1695             


Phe Asp  Gly Leu Thr Asp Ser  Ser Ala Gly Glu Leu  Ser Ser Arg 
    1700                 1705                 1710             


Arg Ser  Leu Pro Asn Lys Thr  Gly Gly Lys Thr Val  Ser Asp Gly 
    1715                 1720                 1725             


Leu His  His Pro Ser Gln Leu  His Ser Lys Leu Glu  Asn Asp Gln 
    1730                 1735                 1740             


Gly Gly  Thr Thr Ser Arg 
    1745                 


<210>  58
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gly Ser Ala Gly Arg Leu His Tyr Leu Ala Met Thr Ala Glu Asn 
1               5                   10                  15      


Pro Thr Pro Gly Asp Leu Ala Pro Ala Pro Leu Ile Thr Cys Lys Leu 
            20                  25                  30          


Cys Leu Cys Glu Gln Ser Leu Asp Lys Met Thr Thr Leu Gln Glu Cys 
        35                  40                  45              


Gln Cys Ile Phe Cys Thr Ala Cys Leu Lys Gln Tyr Met Gln Leu Ala 
    50                  55                  60                  


Ile Arg Glu Gly Cys Gly Ser Pro Ile Thr Cys Pro Asp Met Val Cys 
65                  70                  75                  80  


Leu Asn His Gly Thr Leu Gln Glu Ala Glu Ile Ala Cys Leu Val Pro 
                85                  90                  95      


Val Asp Gln Phe Gln Leu Tyr Gln Arg Leu Lys Phe Glu Arg Glu Val 
            100                 105                 110         


His Leu Asp Pro Tyr Arg Thr Trp Cys Pro Val Ala Asp Cys Gln Thr 
        115                 120                 125             


Val Cys Pro Val Ala Ser Ser Asp Pro Gly Gln Pro Val Leu Val Glu 
    130                 135                 140                 


Cys Pro Ser Cys His Leu Lys Phe Cys Ser Cys Cys Lys Asp Ala Trp 
145                 150                 155                 160 


His Ala Glu Val Ser Cys Arg Asp Ser Gln Pro Ile Val Leu Pro Thr 
                165                 170                 175     


Glu His Arg Ala Leu Phe Gly Thr Asp Ala Glu Ala Pro Ile Lys Gln 
            180                 185                 190         


Cys Pro Val Cys Arg Val Tyr Ile Glu Arg Asn Glu Gly Cys Ala Gln 
        195                 200                 205             


Met Met Cys Lys Asn Cys Lys His Thr Phe Cys Trp Tyr Cys Leu Gln 
    210                 215                 220                 


Asn Leu Asp Asn Asp Ile Phe Leu Arg His Tyr Asp Lys Gly Pro Cys 
225                 230                 235                 240 


Arg Asn Lys Leu Gly His Ser Arg Ala Ser Val Met Trp Asn Arg Thr 
                245                 250                 255     


Gln Val Val Gly Ile Leu Val Gly Leu Gly Ile Ile Ala Leu Val Thr 
            260                 265                 270         


Ser Pro Leu Leu Leu Leu Ala Ser Pro Cys Ile Ile Cys Cys Val Cys 
        275                 280                 285             


Lys Ser Cys Arg Gly Lys Lys Lys Lys His Asp Pro Ser Thr Thr 
    290                 295                 300             


<210>  59
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala 
1               5                   10                  15      


Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe 
            20                  25                  30          


Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser 
        35                  40                  45              


Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys 
    50                  55                  60                  


Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala 
                85                  90                  95      


Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala 
            100                 105                 110         


Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln 
        115                 120                 125             


Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val 
    130                 135                 140                 


Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser 
145                 150                 155                 160 


Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly 
                165                 170                 175     


Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr 
            180                 185                 190         


Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe 
        195                 200                 205             


Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu 
    210                 215                 220                 


Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu 
225                 230                 235                 240 


Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp 
                245                 250                 255     


Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile 
            260                 265                 270         


Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile 
        275                 280                 285             


Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe 
    290                 295                 300                 


Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His 
305                 310                 315                 320 


Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro 
                325                 330                 335     


Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn 
            340                 345                 350         


Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu 
        355                 360                 365             


Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu 
    370                 375                 380                 


Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile 
385                 390                 395                 400 


Leu Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe 
                405                 410                 415     


Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala 
            420                 425                 430         


Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg 
        435                 440                 445             


Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp 
    450                 455                 460                 


Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln 
465                 470                 475                 480 


Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn 
                485                 490                 495     


Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr 
            500                 505                 510         


Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe 
        515                 520                 525             


Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro 
    530                 535                 540                 


Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe 
545                 550                 555                 560 


Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu 
                565                 570                 575     


Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val 
            580                 585                 590         


Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala 
        595                 600                 605             


Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys 
    610                 615                 620                 


His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln 
625                 630                 635                 640 


Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val 
                645                 650                 655     


Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp 
            660                 665                 670         


Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu 
        675                 680                 685             


Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val 
    690                 695                 700                 


Pro Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met 
705                 710                 715                 720 


Glu Glu Val Asp 
                


<210>  60
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ser Asn Tyr Ser Val Ser Leu Val Gly Pro Ala Pro Trp Gly Phe 
1               5                   10                  15      


Arg Leu Gln Gly Gly Lys Asp Phe Asn Met Pro Leu Thr Ile Ser Ser 
            20                  25                  30          


Leu Lys Asp Gly Gly Lys Ala Ala Gln Ala Asn Val Arg Ile Gly Asp 
        35                  40                  45              


Val Val Leu Ser Ile Asp Gly Ile Asn Ala Gln Gly Met Thr His Leu 
    50                  55                  60                  


Glu Ala Gln Asn Lys Ile Lys Gly Cys Thr Gly Ser Leu Asn Met Thr 
65                  70                  75                  80  


Leu Gln Arg Ala Ser Ala Ala Pro Lys Pro Glu Pro Val Pro Val Gln 
                85                  90                  95      


Lys Lys Thr Gln Val Thr Asn Asn Pro Gly Thr Val Lys Ile Pro Pro 
            100                 105                 110         


Lys Arg Pro Pro Arg Lys His Ile Val Glu Arg Tyr Thr Glu Phe Tyr 
        115                 120                 125             


His Val Pro Thr His Ser Asp Ala Ser Lys Lys Arg Leu Ile Glu Asp 
    130                 135                 140                 


Thr Glu Asp Trp Arg Pro Arg Thr Gly Thr Thr Gln Ser Arg Ser Phe 
145                 150                 155                 160 


Arg Ile Leu Ala Gln Ile Thr Gly Thr Glu His Leu Lys Glu Ser Glu 
                165                 170                 175     


Ala Asp Asn Thr Lys Lys Ala Lys Glu Lys Ile Pro Leu His Val Phe 
            180                 185                 190         


Ser Pro Lys Tyr Thr Lys Leu Arg Asp Trp His His Glu Val Ser Ala 
        195                 200                 205             


Arg Ala Leu Asn Val Gln 
    210                 


<210>  61
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Gln Gln Ser Ala Glu Asp Leu 
        35                  40                  45              


Ala Arg Val Pro Ala Asn Ser Thr Ser Asn Ile Leu Asn Arg Leu Leu 
    50                  55                  60                  


Val Ser Tyr Asp Pro Arg Ile Arg Pro Asn Phe Lys Gly Ile Pro Val 
65                  70                  75                  80  


Asp Val Val Val Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Gln Glu 
                85                  90                  95      


Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Lys Trp Asn 
            100                 105                 110         


Asp Pro Arg Leu Lys Leu Pro Ser Asp Phe Arg Gly Ser Asp Ala Leu 
        115                 120                 125             


Thr Val Asp Pro Thr Met Tyr Lys Cys Leu Trp Lys Pro Asp Leu Phe 
    130                 135                 140                 


Phe Ala Asn Glu Lys Ser Ala Asn Phe His Asp Val Thr Gln Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Phe Ile Phe Arg Asp Gly Asp Val Leu Val Ser Met Arg 
                165                 170                 175     


Leu Ser Ile Thr Leu Ser Cys Pro Leu Asp Leu Thr Leu Phe Pro Met 
            180                 185                 190         


Asp Thr Gln Arg Cys Lys Met Gln Leu Glu Ser Phe Gly Tyr Thr Thr 
        195                 200                 205             


Asp Asp Leu Arg Phe Ile Trp Gln Ser Gly Asp Pro Val Gln Leu Glu 
    210                 215                 220                 


Lys Ile Ala Leu Pro Gln Phe Asp Ile Lys Lys Glu Asp Ile Glu Tyr 
225                 230                 235                 240 


Gly Asn Cys Thr Lys Tyr Tyr Lys Gly Thr Gly Tyr Tyr Thr Cys Val 
                245                 250                 255     


Glu Val Ile Phe Thr Leu Arg Arg Gln Val Gly Phe Tyr Met Met Gly 
            260                 265                 270         


Val Tyr Ala Pro Thr Leu Leu Ile Val Val Leu Ser Trp Leu Ser Phe 
        275                 280                 285             


Trp Ile Asn Pro Asp Ala Ser Ala Ala Arg Val Pro Leu Gly Ile Phe 
    290                 295                 300                 


Ser Val Leu Ser Leu Ala Ser Glu Cys Thr Thr Leu Ala Ala Glu Leu 
305                 310                 315                 320 


Pro Lys Val Ser Tyr Val Lys Ala Leu Asp Val Trp Leu Ile Ala Cys 
                325                 330                 335     


Leu Leu Phe Gly Phe Ala Ser Leu Val Glu Tyr Ala Val Val Gln Val 
            340                 345                 350         


Met Leu Asn Asn Pro Lys Arg Val Glu Ala Glu Lys Ala Arg Ile Ala 
        355                 360                 365             


Lys Ala Glu Gln Ala Asp Gly Lys Gly Gly Asn Val Ala Lys Lys Asn 
    370                 375                 380                 


Thr Val Asn Gly Thr Gly Thr Pro Val His Ile Ser Thr Leu Gln Val 
385                 390                 395                 400 


Gly Glu Thr Arg Cys Lys Lys Val Cys Thr Ser Lys Ser Asp Leu Arg 
                405                 410                 415     


Ser Asn Asp Phe Ser Ile Val Gly Ser Leu Pro Arg Asp Phe Glu Leu 
            420                 425                 430         


Ser Asn Tyr Asp Cys Tyr Gly Lys Pro Ile Glu Val Asn Asn Gly Leu 
        435                 440                 445             


Gly Lys Ser Gln Ala Lys Asn Asn Lys Lys Pro Pro Pro Ala Lys Pro 
    450                 455                 460                 


Val Ile Pro Thr Ala Ala Lys Arg Ile Asp Leu Tyr Ala Arg Ala Leu 
465                 470                 475                 480 


Phe Pro Phe Cys Phe Leu Phe Phe Asn Val Ile Tyr Trp Ser Ile Tyr 
                485                 490                 495     


Leu 
    


<210>  62
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Ser Glu Ala Pro Ser Pro Pro Arg Ser Pro Pro Pro Pro Thr 
1               5                   10                  15      


Ser Pro Glu Pro Glu Leu Ala Gln Leu Arg Arg Lys Val Glu Lys Leu 
            20                  25                  30          


Glu Arg Glu Leu Arg Ser Cys Lys Arg Gln Val Arg Glu Ile Glu Lys 
        35                  40                  45              


Leu Leu His His Thr Glu Arg Leu Tyr Gln Asn Ala Glu Ser Asn Asn 
    50                  55                  60                  


Gln Glu Leu Arg Thr Gln Val Glu Glu Leu Ser Lys Ile Leu Gln Arg 
65                  70                  75                  80  


Gly Arg Asn Glu Asp Asn Lys Lys Ser Asp Val Glu Val Gln Thr Glu 
                85                  90                  95      


Asn His Ala Pro Trp Ser Ile Ser Asp Tyr Phe Tyr Gln Thr Tyr Tyr 
            100                 105                 110         


Asn Asp Val Ser Leu Pro Asn Lys Val Thr Glu Leu Ser Asp Gln Gln 
        115                 120                 125             


Asp Gln Ala Ile Glu Thr Ser Ile Leu Asn Ser Lys Asp His Leu Gln 
    130                 135                 140                 


Val Glu Asn Asp Ala Tyr Pro Gly Thr Asp Arg Thr Glu Asn Val Lys 
145                 150                 155                 160 


Tyr Arg Gln Val Asp His Phe Ala Ser Asn Ser Gln Glu Pro Ala Ser 
                165                 170                 175     


Ala Leu Ala Thr Glu Asp Thr Ser Leu Glu Gly Ser Ser Leu Ala Glu 
            180                 185                 190         


Ser Leu Arg Ala Ala Ala Glu Ala Ala Val Ser Gln Thr Gly Phe Ser 
        195                 200                 205             


Tyr Asp Glu Asn Thr Gly Leu Tyr Phe Asp His Ser Thr Gly Phe Tyr 
    210                 215                 220                 


Tyr Asp Ser Glu Asn Gln Leu Tyr Tyr Asp Pro Ser Thr Gly Ile Tyr 
225                 230                 235                 240 


Tyr Tyr Cys Asp Val Glu Ser Gly Arg Tyr Gln Phe His Ser Arg Val 
                245                 250                 255     


Asp Leu Gln Pro Tyr Pro Thr Ser Ser Thr Lys Gln Ser Lys Asp Lys 
            260                 265                 270         


Lys Leu Lys Lys Lys Arg Lys Asp Pro Asp Ser Ser Ala Thr Asn Glu 
        275                 280                 285             


Glu Lys Asp Leu Asn Ser Glu Asp Gln Lys Ala Phe Ser Val Glu His 
    290                 295                 300                 


Thr Ser Cys Asn Glu Glu Glu Asn Phe Ala Asn Met Lys Lys Lys Ala 
305                 310                 315                 320 


Lys Ile Gly Ile His His Lys Asn Ser Pro Pro Lys Val Thr Val Pro 
                325                 330                 335     


Thr Ser Gly Asn Thr Ile Glu Ser Pro Leu His Glu Asn Ile Ser Asn 
            340                 345                 350         


Ser Thr Ser Phe Lys Asp Glu Lys Ile Met Glu Thr Asp Ser Glu Pro 
        355                 360                 365             


Glu Glu Gly Glu Ile Thr Asp Ser Gln Thr Glu Asp Ser Tyr Asp Glu 
    370                 375                 380                 


Ala Ile Thr Ser Glu Gly Asn Val Thr Ala Glu Asp Ser Glu Asp Glu 
385                 390                 395                 400 


Asp Glu Asp Lys Ile Trp Pro Pro Cys Ile Arg Val Ile Val Ile Arg 
                405                 410                 415     


Ser Pro Val Leu Gln Ile Gly Ser Leu Phe Ile Ile Thr Ala Val Asn 
            420                 425                 430         


Pro Ala Thr Ile Gly Arg Glu Lys Asp Met Glu His Thr Leu Arg Ile 
        435                 440                 445             


Pro Glu Val Gly Val Ser Lys Phe His Ala Glu Ile Tyr Phe Asp His 
    450                 455                 460                 


Asp Leu Gln Ser Tyr Val Leu Val Asp Gln Gly Ser Gln Asn Gly Thr 
465                 470                 475                 480 


Ile Val Asn Gly Lys Gln Ile Leu Gln Pro Lys Thr Lys Cys Asp Pro 
                485                 490                 495     


Tyr Val Leu Glu His Gly Asp Glu Val Lys Ile Gly Glu Thr Val Leu 
            500                 505                 510         


Ser Phe His Ile His Pro Gly Ser Asp Thr Cys Asp Gly Cys Glu Pro 
        515                 520                 525             


Gly Gln Val Arg Ala His Leu Arg Leu Asp Lys Lys Asp Glu Ser Phe 
    530                 535                 540                 


Val Gly Pro Thr Leu Ser Lys Glu Glu Lys Glu Leu Glu Arg Arg Lys 
545                 550                 555                 560 


Glu Leu Lys Lys Ile Arg Val Lys Tyr Gly Leu Gln Asn Thr Glu Tyr 
                565                 570                 575     


Glu Asp Glu Lys Thr Leu Lys Asn Pro Lys Tyr Lys Asp Arg Ala Gly 
            580                 585                 590         


Lys Arg Arg Glu Gln Val Gly Ser Glu Gly Thr Phe Gln Arg Asp Asp 
        595                 600                 605             


Ala Pro Ala Ser Val His Ser Glu Ile Thr Asp Ser Asn Lys Gly Arg 
    610                 615                 620                 


Lys Met Leu Glu Lys Met Gly Trp Lys Lys Gly Glu Gly Leu Gly Lys 
625                 630                 635                 640 


Asp Gly Gly Gly Met Lys Thr Pro Ile Gln Leu Gln Leu Arg Arg Thr 
                645                 650                 655     


His Ala Gly Leu Gly Thr Gly Lys Pro Ser Ser Phe Glu Asp Val His 
            660                 665                 670         


Leu Leu Gln Asn Lys Asn Lys Lys Asn Trp Asp Lys Ala Arg Glu Arg 
        675                 680                 685             


Phe Thr Glu Asn Phe Pro Glu Thr Lys Pro Gln Lys Asp Asp Pro Gly 
    690                 695                 700                 


Thr Met Pro Trp Val Lys Gly Thr Leu Glu 
705                 710                 


<210>  63
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Asn Trp Glu Leu Leu Leu Trp Leu Leu Val Leu Cys Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Leu Leu Arg Phe Leu Arg Ala Asp Gly Asp Leu 
            20                  25                  30          


Thr Leu Leu Trp Ala Glu Trp Gln Gly Arg Arg Pro Glu Trp Glu Leu 
        35                  40                  45              


Thr Asp Met Val Val Trp Val Thr Gly Ala Ser Ser Gly Ile Gly Glu 
    50                  55                  60                  


Glu Leu Ala Tyr Gln Leu Ser Lys Leu Gly Val Ser Leu Val Leu Ser 
65                  70                  75                  80  


Ala Arg Arg Val His Glu Leu Glu Arg Val Lys Arg Arg Cys Leu Glu 
                85                  90                  95      


Asn Gly Asn Leu Lys Glu Lys Asp Ile Leu Val Leu Pro Leu Asp Leu 
            100                 105                 110         


Thr Asp Thr Gly Ser His Glu Ala Ala Thr Lys Ala Val Leu Gln Glu 
        115                 120                 125             


Phe Gly Arg Ile Asp Ile Leu Val Asn Asn Gly Gly Met Ser Gln Arg 
    130                 135                 140                 


Ser Leu Cys Met Asp Thr Ser Leu Asp Val Tyr Arg Lys Leu Ile Glu 
145                 150                 155                 160 


Leu Asn Tyr Leu Gly Thr Val Ser Leu Thr Lys Cys Val Leu Pro His 
                165                 170                 175     


Met Ile Glu Arg Lys Gln Gly Lys Ile Val Thr Val Asn Ser Ile Leu 
            180                 185                 190         


Gly Ile Ile Ser Val Pro Leu Ser Ile Gly Tyr Cys Ala Ser Lys His 
        195                 200                 205             


Ala Leu Arg Gly Phe Phe Asn Gly Leu Arg Thr Glu Leu Ala Thr Tyr 
    210                 215                 220                 


Pro Gly Ile Ile Val Ser Asn Ile Cys Pro Gly Pro Val Gln Ser Asn 
225                 230                 235                 240 


Ile Val Glu Asn Ser Leu Ala Gly Glu Val Thr Lys Thr Ile Gly Asn 
                245                 250                 255     


Asn Gly Asp Gln Ser His Lys Met Thr Thr Ser Arg Cys Val Arg Leu 
            260                 265                 270         


Met Leu Ile Ser Met Ala Asn Asp Leu Lys Glu Val Trp Ile Ser Glu 
        275                 280                 285             


Gln Pro Phe Leu Leu Val Thr Tyr Leu Trp Gln Tyr Met Pro Thr Trp 
    290                 295                 300                 


Ala Trp Trp Ile Thr Asn Lys Met Gly Lys Lys Arg Ile Glu Asn Phe 
305                 310                 315                 320 


Lys Ser Gly Val Asp Ala Asp Ser Ser Tyr Phe Lys Ile Phe Lys Thr 
                325                 330                 335     


Lys His Asp 
            


<210>  64
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     


Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala 
            420                 425                 430         


Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro 
        435                 440                 445             


Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro 
    450                 455                 460                 


Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu 
465                 470                 475                 480 


Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln 
                485                 490                 495     


Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu 
            500                 505                 510         


Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr 
        515                 520                 525             


Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser 
    530                 535                 540                 


Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu 
545                 550                 555                 560 


Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu 
                565                 570                 575     


Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln 
            580                 585                 590         


Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala 
        595                 600                 605             


Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile 
    610                 615                 620                 


Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635                 640 


<210>  65
<211>  1074
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ile Ser Ala Asp Cys Asn Leu Cys Leu Pro Glu Tyr Asp Arg Tyr 
1               5                   10                  15      


Leu Ala Ser Ser Lys Ile Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu 
            20                  25                  30          


Asn His Thr Pro Asn Ser Ser Thr Lys Thr His Leu Gly Thr Gly Met 
        35                  40                  45              


Glu Arg Ser Pro Gly Ala Met Glu Arg Val Leu Lys Val Phe His Tyr 
    50                  55                  60                  


Phe Glu Ser Asn Ser Glu Pro Thr Thr Trp Ala Ser Ile Ile Arg His 
65                  70                  75                  80  


Gly Asp Ala Thr Asp Val Arg Gly Ile Ile Gln Lys Ile Val Asp Ser 
                85                  90                  95      


His Lys Val Lys His Val Ala Cys Tyr Gly Phe Arg Leu Ser His Leu 
            100                 105                 110         


Arg Ser Glu Glu Val His Trp Leu His Val Asp Met Gly Val Ser Ser 
        115                 120                 125             


Val Arg Glu Lys Tyr Glu Leu Ala His Pro Pro Glu Glu Trp Lys Tyr 
    130                 135                 140                 


Glu Leu Arg Ile Arg Tyr Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr 
145                 150                 155                 160 


Glu Asp Lys Pro Thr Leu Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp 
                165                 170                 175     


Tyr Met Leu Glu Ile Ala Asp Gln Val Asp Gln Glu Ile Ala Leu Lys 
            180                 185                 190         


Leu Gly Cys Leu Glu Ile Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn 
        195                 200                 205             


Ala Leu Glu Lys Lys Ser Asn Tyr Glu Val Leu Glu Lys Asp Val Gly 
    210                 215                 220                 


Leu Lys Arg Phe Phe Pro Lys Ser Leu Leu Asp Ser Val Lys Ala Lys 
225                 230                 235                 240 


Thr Leu Arg Lys Leu Ile Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu 
                245                 250                 255     


Asn Arg Glu Glu Ser Ile Leu Lys Phe Phe Glu Ile Leu Ser Pro Val 
            260                 265                 270         


Tyr Arg Phe Asp Lys Glu Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp 
        275                 280                 285             


Ile Ile Ser Val Glu Leu Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr 
    290                 295                 300                 


Leu Thr Asp Lys Gly Cys Asn Pro Thr His Leu Ala Asp Phe Thr Gln 
305                 310                 315                 320 


Val Gln Thr Ile Gln Tyr Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly 
                325                 330                 335     


Met Leu Gln Leu Lys Ile Ala Gly Ala Pro Glu Pro Leu Thr Val Thr 
            340                 345                 350         


Ala Pro Ser Leu Thr Ile Ala Glu Asn Met Ala Asp Leu Ile Asp Gly 
        355                 360                 365             


Tyr Cys Arg Leu Val Asn Gly Thr Ser Gln Ser Phe Ile Ile Arg Pro 
    370                 375                 380                 


Gln Lys Glu Gly Glu Arg Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn 
385                 390                 395                 400 


Ser Glu Lys Gln Gly Met Arg Thr His Ala Val Ser Val Ser Glu Thr 
                405                 410                 415     


Asp Asp Tyr Ala Glu Ile Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro 
            420                 425                 430         


Ser Thr Arg Asp Tyr Glu Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg 
        435                 440                 445             


Cys Ile Gly Glu Gly Gln Phe Gly Asp Val His Gln Gly Ile Tyr Met 
    450                 455                 460                 


Ser Pro Glu Asn Pro Ala Leu Ala Val Ala Ile Lys Thr Cys Lys Asn 
465                 470                 475                 480 


Cys Thr Ser Asp Ser Val Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr 
                485                 490                 495     


Met Arg Gln Phe Asp His Pro His Ile Val Lys Leu Ile Gly Val Ile 
            500                 505                 510         


Thr Glu Asn Pro Val Trp Ile Ile Met Glu Leu Cys Thr Leu Gly Glu 
        515                 520                 525             


Leu Arg Ser Phe Leu Gln Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser 
    530                 535                 540                 


Leu Ile Leu Tyr Ala Tyr Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu 
545                 550                 555                 560 


Ser Lys Arg Phe Val His Arg Asp Ile Ala Ala Arg Asn Val Leu Val 
                565                 570                 575     


Ser Ser Asn Asp Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr 
            580                 585                 590         


Met Glu Asp Ser Thr Tyr Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile 
        595                 600                 605             


Lys Trp Met Ala Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala 
    610                 615                 620                 


Ser Asp Val Trp Met Phe Gly Val Cys Met Trp Glu Ile Leu Met His 
625                 630                 635                 640 


Gly Val Lys Pro Phe Gln Gly Val Lys Asn Asn Asp Val Ile Gly Arg 
                645                 650                 655     


Ile Glu Asn Gly Glu Arg Leu Pro Met Pro Pro Asn Cys Pro Pro Thr 
            660                 665                 670         


Leu Tyr Ser Leu Met Thr Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg 
        675                 680                 685             


Pro Arg Phe Thr Glu Leu Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu 
    690                 695                 700                 


Glu Lys Ala Gln Gln Glu Glu Arg Met Arg Met Glu Ser Arg Arg Gln 
705                 710                 715                 720 


Ala Thr Val Ser Trp Asp Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys 
                725                 730                 735     


Pro Ser Arg Pro Gly Tyr Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr 
            740                 745                 750         


Pro Ser Pro Gln His Met Val Gln Thr Asn His Tyr Gln Val Ser Gly 
        755                 760                 765             


Tyr Pro Gly Ser His Gly Ile Thr Ala Met Ala Gly Ser Ile Tyr Pro 
    770                 775                 780                 


Gly Gln Ala Ser Leu Leu Asp Gln Thr Asp Ser Trp Asn His Arg Pro 
785                 790                 795                 800 


Gln Glu Ile Ala Met Trp Gln Pro Asn Val Glu Asp Ser Thr Val Leu 
                805                 810                 815     


Asp Leu Arg Gly Ile Gly Gln Val Leu Pro Thr His Leu Met Glu Glu 
            820                 825                 830         


Arg Leu Ile Arg Gln Gln Gln Glu Met Glu Glu Asp Gln Arg Trp Leu 
        835                 840                 845             


Glu Lys Glu Glu Arg Phe Leu Lys Pro Asp Val Arg Leu Ser Arg Gly 
    850                 855                 860                 


Ser Ile Asp Arg Glu Asp Gly Ser Leu Gln Gly Pro Ile Gly Asn Gln 
865                 870                 875                 880 


His Ile Tyr Gln Pro Val Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys 
                885                 890                 895     


Lys Pro Pro Arg Pro Gly Ala Pro Gly His Leu Gly Ser Leu Ala Ser 
            900                 905                 910         


Leu Ser Ser Pro Ala Asp Ser Tyr Asn Glu Gly Val Lys Leu Gln Pro 
        915                 920                 925             


Gln Glu Ile Ser Pro Pro Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp 
    930                 935                 940                 


Lys Val Tyr Glu Asn Val Thr Gly Leu Val Lys Ala Val Ile Glu Met 
945                 950                 955                 960 


Ser Ser Lys Ile Gln Pro Ala Pro Pro Glu Glu Tyr Val Pro Met Val 
                965                 970                 975     


Lys Glu Val Gly Leu Ala Leu Arg Thr Leu Leu Ala Thr Val Asp Glu 
            980                 985                 990         


Thr Ile Pro Leu Leu Pro Ala Ser  Thr His Arg Glu Ile  Glu Met Ala 
        995                 1000                 1005             


Gln Lys  Leu Leu Asn Ser Asp  Leu Gly Glu Leu Ile  Asn Lys Met 
    1010                 1015                 1020             


Lys Leu  Ala Gln Gln Tyr Val  Met Thr Ser Leu Gln  Gln Glu Tyr 
    1025                 1030                 1035             


Lys Lys  Gln Met Leu Thr Ala  Ala His Ala Leu Ala  Val Asp Ala 
    1040                 1045                 1050             


Lys Asn  Leu Leu Asp Val Ile  Asp Gln Ala Arg Leu  Lys Met Leu 
    1055                 1060                 1065             


Gly Gln  Thr Arg Pro His 
    1070                 


<210>  66
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Asp Ser Cys Thr Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Gly Ala Ser Asp Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210>  67
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Lys Pro Ala Leu Phe Ser Val Leu Cys Glu Ile Lys Glu Lys Thr 
1               5                   10                  15      


Gly Leu Ser Ile Arg Gly Ala Gln Glu Glu Asp Pro Pro Asp Pro Gln 
            20                  25                  30          


Leu Met Arg Leu Asp Asn Met Leu Leu Ala Glu Gly Val Ser Gly Pro 
        35                  40                  45              


Glu Lys Gly Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser 
    50                  55                  60                  


Gly Gly Ser Ser Asp Asn Ser Ile Glu His Ser Asp Tyr Arg Ala Lys 
65                  70                  75                  80  


Leu Thr Gln Ile Arg Gln Ile Tyr His Thr Glu Leu Glu Lys Tyr Glu 
                85                  90                  95      


Gln Ala Cys Asn Glu Phe Thr Thr His Val Met Asn Leu Leu Arg Glu 
            100                 105                 110         


Gln Ser Arg Thr Arg Pro Ile Ser Pro Lys Glu Ile Glu Arg Met Val 
        115                 120                 125             


Gly Ile Ile His Arg Lys Phe Ser Ser Ile Gln Met Gln Leu Lys Gln 
    130                 135                 140                 


Ser Thr Cys Glu Ala Val Met Ile Leu Arg Ser Arg Phe Leu Asp Ala 
145                 150                 155                 160 


Arg Arg Lys Arg Arg Asn Phe Ser Lys Gln Ala Thr Glu Ile Leu Asn 
                165                 170                 175     


Glu Tyr Phe Tyr Ser His Leu Ser Asn Pro Tyr Pro Ser Glu Glu Ala 
            180                 185                 190         


Lys Glu Glu Leu Ala Lys Lys Cys Ser Ile Thr Val Ser Gln Val Ser 
        195                 200                 205             


Asn Trp Phe Gly Asn Lys Arg Ile Arg Tyr Lys Lys Asn Ile Gly Lys 
    210                 215                 220                 


Phe Gln Glu Glu Ala Asn Leu Tyr Ala Ala Lys Thr Ala Val Thr Ala 
225                 230                 235                 240 


Ala His Ala Val Ala Ala Ala Val Gln Asn Asn Gln Thr Asn Ser Pro 
                245                 250                 255     


Thr Thr Pro Asn Ser Gly Ser Ser Gly Ser Phe Asn Leu Pro Asn Ser 
            260                 265                 270         


Gly Asp Met Phe Met Asn Met Gln Ser Leu Asn Gly Asp Ser Tyr Gln 
        275                 280                 285             


Gly Ser Gln Val Gly Ala Asn Val Gln Ser Gln Val Asp Thr Leu Arg 
    290                 295                 300                 


His Val Ile Asn Gln Thr Gly Gly Tyr Ser Asp Gly Leu Gly Gly Asn 
305                 310                 315                 320 


Ser Leu Tyr Ser Pro His Asn Leu Asn Ala Asn Gly Gly Trp Gln Asp 
                325                 330                 335     


Ala Thr Thr Pro Ser Ser Val Thr Ser Pro Thr Glu Gly Pro Gly Ser 
            340                 345                 350         


Val His Ser Asp Thr Ser Asn 
        355                 


<210>  68
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 
            20                  25                  30          


Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser 
        35                  40                  45              


Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr 
    50                  55                  60                  


Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys 
65                  70                  75                  80  


Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr Ser Ala 
                85                  90                  95      


Val Ala Ala 
            


<210>  69
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Thr Gly Glu Arg Pro Ser Thr Ala Leu Pro Asp Arg Arg Trp Gly 
1               5                   10                  15      


Pro Arg Ile Leu Gly Phe Trp Gly Gly Cys Arg Val Trp Val Phe Ala 
            20                  25                  30          


Ala Ile Phe Leu Leu Leu Ser Leu Ala Ala Ser Trp Ser Lys Ala Glu 
        35                  40                  45              


Asn Asp Phe Gly Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu Leu 
    50                  55                  60                  


Trp Val Ser Gly Arg Gln Ile Gly Ser Val Asp Thr Phe Arg Ile Pro 
65                  70                  75                  80  


Leu Ile Thr Ala Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu Ala 
                85                  90                  95      


Arg Lys Met Ser Ser Ser Asp Glu Gly Ala Lys Phe Ile Ala Leu Arg 
            100                 105                 110         


Arg Ser Met Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile Val 
        115                 120                 125             


Asn Asp Gly Asp Val Pro Asp Gly Leu Asn Leu Gly Ala Val Val Ser 
    130                 135                 140                 


Asp Val Glu Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala His 
145                 150                 155                 160 


Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys Asp 
                165                 170                 175     


Asp Gly Val Ser Trp Ser Thr Pro Arg Asn Leu Ser Leu Asp Ile Gly 
            180                 185                 190         


Thr Glu Val Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln Arg 
        195                 200                 205             


Glu Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu Glu 
    210                 215                 220                 


Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser Trp 
225                 230                 235                 240 


Arg Tyr Gly Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys Gln 
                245                 250                 255     


Glu Asn Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro Asp 
            260                 265                 270         


Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys His 
        275                 280                 285             


Cys Arg Ile Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg Pro 
    290                 295                 300                 


Arg Asp Val Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala Ala 
305                 310                 315                 320 


Gly Ala Val Val Thr Ser Ser Gly Ile Val Phe Phe Ser Asn Pro Ala 
                325                 330                 335     


His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser Asn 
            340                 345                 350         


Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro Ser 
        355                 360                 365             


Gly Tyr Ser Ser Leu Ala Thr Leu Glu Gly Ser Met Asp Gly Glu Glu 
    370                 375                 380                 


Gln Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn His Tyr 
385                 390                 395                 400 


Thr Glu Ser Ile Ser Val Ala Lys Ile Ser Val Tyr Gly Thr Leu 
                405                 410                 415 


<210>  70
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Met Ala Glu Gly Glu Arg Thr Glu Cys Ala Glu Pro Pro Arg 
1               5                   10                  15      


Asp Glu Pro Pro Ala Asp Gly Ala Leu Lys Arg Ala Glu Glu Leu Lys 
            20                  25                  30          


Thr Gln Ala Asn Asp Tyr Phe Lys Ala Lys Asp Tyr Glu Asn Ala Ile 
        35                  40                  45              


Lys Phe Tyr Ser Gln Ala Ile Glu Leu Asn Pro Ser Asn Ala Ile Tyr 
    50                  55                  60                  


Tyr Gly Asn Arg Ser Leu Ala Tyr Leu Arg Thr Glu Cys Tyr Gly Tyr 
65                  70                  75                  80  


Ala Leu Gly Asp Ala Thr Arg Ala Ile Glu Leu Asp Lys Lys Tyr Ile 
                85                  90                  95      


Lys Gly Tyr Tyr Arg Arg Ala Ala Ser Asn Met Ala Leu Gly Lys Phe 
            100                 105                 110         


Arg Ala Ala Leu Arg Asp Tyr Glu Thr Val Val Lys Val Lys Pro His 
        115                 120                 125             


Asp Lys Asp Ala Lys Met Lys Tyr Gln Glu Cys Asn Lys Ile Val Lys 
    130                 135                 140                 


Gln Lys Ala Phe Glu Arg Ala Ile Ala Gly Asp Glu His Lys Arg Ser 
145                 150                 155                 160 


Val Val Asp Ser Leu Asp Ile Glu Ser Met Thr Ile Glu Asp Glu Tyr 
                165                 170                 175     


Ser Gly Pro Lys Leu Glu Asp Gly Lys Val Thr Ile Ser Phe Met Lys 
            180                 185                 190         


Glu Leu Met Gln Trp Tyr Lys Asp Gln Lys Lys Leu His Arg Lys Cys 
        195                 200                 205             


Ala Tyr Gln Ile Leu Val Gln Val Lys Glu Val Leu Ser Lys Leu Ser 
    210                 215                 220                 


Thr Leu Val Glu Thr Thr Leu Lys Glu Thr Glu Lys Ile Thr Val Cys 
225                 230                 235                 240 


Gly Asp Thr His Gly Gln Phe Tyr Asp Leu Leu Asn Ile Phe Glu Leu 
                245                 250                 255     


Asn Gly Leu Pro Ser Glu Thr Asn Pro Tyr Ile Phe Asn Gly Asp Phe 
            260                 265                 270         


Val Asp Arg Gly Ser Phe Ser Val Glu Val Ile Leu Thr Leu Phe Gly 
        275                 280                 285             


Phe Lys Leu Leu Tyr Pro Asp His Phe His Leu Leu Arg Gly Asn His 
    290                 295                 300                 


Glu Thr Asp Asn Met Asn Gln Ile Tyr Gly Phe Glu Gly Glu Val Lys 
305                 310                 315                 320 


Ala Lys Tyr Thr Ala Gln Met Tyr Glu Leu Phe Ser Glu Val Phe Glu 
                325                 330                 335     


Trp Leu Pro Leu Ala Gln Cys Ile Asn Gly Lys Val Leu Ile Met His 
            340                 345                 350         


Gly Gly Leu Phe Ser Glu Asp Gly Val Thr Leu Asp Asp Ile Arg Lys 
        355                 360                 365             


Ile Glu Arg Asn Arg Gln Pro Pro Asp Ser Gly Pro Met Cys Asp Leu 
    370                 375                 380                 


Leu Trp Ser Asp Pro Gln Pro Gln Asn Gly Arg Ser Ile Ser Lys Arg 
385                 390                 395                 400 


Gly Val Ser Cys Gln Phe Gly Pro Asp Val Thr Lys Ala Phe Leu Glu 
                405                 410                 415     


Glu Asn Asn Leu Asp Tyr Ile Ile Arg Ser His Glu Val Lys Ala Glu 
            420                 425                 430         


Gly Tyr Glu Val Ala His Gly Gly Arg Cys Val Thr Val Phe Ser Ala 
        435                 440                 445             


Pro Asn Tyr Cys Asp Gln Met Gly Asn Lys Ala Ser Tyr Ile His Leu 
    450                 455                 460                 


Gln Gly Ser Asp Leu Arg Pro Gln Phe His Gln Phe Thr Ala Val Pro 
465                 470                 475                 480 


His Pro Asn Val Lys Pro Met Ala Tyr Ala Asn Thr Leu Leu Gln Leu 
                485                 490                 495     


Gly Met Met 
            


<210>  71
<211>  699
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Gly Pro Ala Pro Ala Gly Glu Gln Leu Arg Gly Ala Thr Gly Glu 
1               5                   10                  15      


Pro Glu Val Met Glu Pro Ala Leu Glu Gly Thr Gly Lys Glu Gly Lys 
            20                  25                  30          


Lys Ala Ser Ser Arg Lys Arg Thr Leu Ala Glu Pro Pro Ala Lys Gly 
        35                  40                  45              


Leu Leu Gln Pro Val Lys Leu Ser Arg Ala Glu Leu Tyr Lys Glu Pro 
    50                  55                  60                  


Thr Asn Glu Glu Leu Asn Arg Leu Arg Glu Thr Glu Ile Leu Phe His 
65                  70                  75                  80  


Ser Ser Leu Leu Arg Leu Gln Val Glu Glu Leu Leu Lys Glu Val Arg 
                85                  90                  95      


Leu Ser Glu Lys Lys Lys Asp Arg Ile Asp Ala Phe Leu Arg Glu Val 
            100                 105                 110         


Asn Gln Arg Val Val Arg Val Pro Ser Val Pro Glu Thr Glu Leu Thr 
        115                 120                 125             


Asp Gln Ala Trp Leu Pro Ala Gly Val Arg Val Pro Leu His Gln Val 
    130                 135                 140                 


Pro Tyr Ala Val Lys Gly Cys Phe Arg Phe Leu Pro Pro Ala Gln Val 
145                 150                 155                 160 


Thr Val Val Gly Ser Tyr Leu Leu Gly Thr Cys Ile Arg Pro Asp Ile 
                165                 170                 175     


Asn Val Asp Val Ala Leu Thr Met Pro Arg Glu Ile Leu Gln Asp Lys 
            180                 185                 190         


Asp Gly Leu Asn Gln Arg Tyr Phe Arg Lys Arg Ala Leu Tyr Leu Ala 
        195                 200                 205             


His Leu Ala His His Leu Ala Gln Asp Pro Leu Phe Gly Ser Val Cys 
    210                 215                 220                 


Phe Ser Tyr Thr Asn Gly Cys His Leu Lys Pro Ser Leu Leu Leu Arg 
225                 230                 235                 240 


Pro Arg Gly Lys Asp Glu Arg Leu Val Thr Val Arg Leu His Pro Cys 
                245                 250                 255     


Pro Pro Pro Asp Phe Phe Arg Pro Cys Arg Leu Leu Pro Thr Lys Asn 
            260                 265                 270         


Asn Val Arg Ser Ala Trp Tyr Arg Gly Gln Ser Pro Ala Gly Asp Gly 
        275                 280                 285             


Ser Pro Glu Pro Pro Thr Pro Arg Tyr Asn Thr Trp Val Leu Gln Asp 
    290                 295                 300                 


Thr Val Leu Glu Ser His Leu Gln Leu Leu Ser Thr Ile Leu Ser Ser 
305                 310                 315                 320 


Ala Gln Gly Leu Lys Asp Gly Val Ala Leu Leu Lys Val Trp Leu Arg 
                325                 330                 335     


Gln Arg Glu Leu Asp Lys Gly Gln Gly Gly Phe Thr Gly Phe Leu Val 
            340                 345                 350         


Ser Met Leu Val Val Phe Leu Val Ser Thr Arg Lys Ile His Thr Thr 
        355                 360                 365             


Met Ser Gly Tyr Gln Val Leu Arg Ser Val Leu Gln Phe Leu Ala Thr 
    370                 375                 380                 


Thr Asp Leu Thr Val Asn Gly Ile Ser Leu Cys Leu Ser Ser Asp Pro 
385                 390                 395                 400 


Ser Leu Pro Ala Leu Ala Asp Phe His Gln Ala Phe Ser Val Val Phe 
                405                 410                 415     


Leu Asp Ser Ser Gly His Leu Asn Leu Cys Ala Asp Val Thr Ala Ser 
            420                 425                 430         


Thr Tyr His Gln Val Gln His Glu Ala Arg Leu Ser Met Met Leu Leu 
        435                 440                 445             


Asp Ser Arg Ala Asp Asp Gly Phe His Leu Leu Leu Met Thr Pro Lys 
    450                 455                 460                 


Pro Met Ile Arg Ala Phe Asp His Val Leu His Leu Arg Pro Leu Ser 
465                 470                 475                 480 


Arg Leu Gln Ala Ala Cys His Arg Leu Lys Leu Trp Pro Glu Leu Gln 
                485                 490                 495     


Asp Asn Gly Gly Asp Tyr Val Ser Ala Ala Leu Gly Pro Leu Thr Thr 
            500                 505                 510         


Leu Leu Glu Gln Gly Leu Gly Ala Arg Leu Asn Leu Leu Ala His Ser 
        515                 520                 525             


Arg Pro Pro Val Pro Glu Trp Asp Ile Ser Gln Asp Pro Pro Lys His 
    530                 535                 540                 


Lys Asp Ser Gly Thr Leu Thr Leu Gly Leu Leu Leu Arg Pro Glu Gly 
545                 550                 555                 560 


Leu Thr Ser Val Leu Glu Leu Gly Pro Glu Ala Asp Gln Pro Glu Ala 
                565                 570                 575     


Ala Lys Phe Arg Gln Phe Trp Gly Ser Arg Ser Glu Leu Arg Arg Phe 
            580                 585                 590         


Gln Asp Gly Ala Ile Arg Glu Ala Val Val Trp Glu Ala Ala Ser Met 
        595                 600                 605             


Ser Gln Lys Arg Leu Ile Pro His Gln Val Val Thr His Leu Leu Ala 
    610                 615                 620                 


Leu His Ala Asp Ile Pro Glu Thr Cys Val His Tyr Val Gly Gly Pro 
625                 630                 635                 640 


Leu Asp Ala Leu Ile Gln Gly Leu Lys Glu Ala Ser Ser Thr Lys Gly 
                645                 650                 655     


Arg Met Val Met Ser Arg Gly Gly Glu Leu Val Met Val Pro Asn Val 
            660                 665                 670         


Glu Ala Ile Leu Glu Asp Phe Ala Val Leu Gly Glu Gly Leu Val Gln 
        675                 680                 685             


Thr Val Glu Ala Arg Ser Glu Arg Trp Thr Val 
    690                 695                 


<210>  72
<211>  3114
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ser Trp Ala Leu Glu Glu Trp Lys Glu Gly Leu Pro Thr Arg Ala 
1               5                   10                  15      


Leu Gln Lys Ile Gln Glu Leu Glu Gly Gln Leu Asp Lys Leu Lys Lys 
            20                  25                  30          


Glu Lys Gln Gln Arg Gln Phe Gln Leu Asp Ser Leu Glu Ala Ala Leu 
        35                  40                  45              


Gln Lys Gln Lys Gln Lys Val Glu Asn Glu Lys Thr Glu Gly Thr Asn 
    50                  55                  60                  


Leu Lys Arg Glu Asn Gln Arg Leu Met Glu Ile Cys Glu Ser Leu Glu 
65                  70                  75                  80  


Lys Thr Lys Gln Lys Ile Ser His Glu Leu Gln Val Lys Glu Ser Gln 
                85                  90                  95      


Val Asn Phe Gln Glu Gly Gln Leu Asn Ser Gly Lys Lys Gln Ile Glu 
            100                 105                 110         


Lys Leu Glu Gln Glu Leu Lys Arg Cys Lys Ser Glu Leu Glu Arg Ser 
        115                 120                 125             


Gln Gln Ala Ala Gln Ser Ala Asp Val Ser Leu Asn Pro Cys Asn Thr 
    130                 135                 140                 


Pro Gln Lys Ile Phe Thr Thr Pro Leu Thr Pro Ser Gln Tyr Tyr Ser 
145                 150                 155                 160 


Gly Ser Lys Tyr Glu Asp Leu Lys Glu Lys Tyr Asn Lys Glu Val Glu 
                165                 170                 175     


Glu Arg Lys Arg Leu Glu Ala Glu Val Lys Ala Leu Gln Ala Lys Lys 
            180                 185                 190         


Ala Ser Gln Thr Leu Pro Gln Ala Thr Met Asn His Arg Asp Ile Ala 
        195                 200                 205             


Arg His Gln Ala Ser Ser Ser Val Phe Ser Trp Gln Gln Glu Lys Thr 
    210                 215                 220                 


Pro Ser His Leu Ser Ser Asn Ser Gln Arg Thr Pro Ile Arg Arg Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Tyr Phe Ser Gly Glu Gln Glu Val Thr Pro Ser Arg 
                245                 250                 255     


Ser Thr Leu Gln Ile Gly Lys Arg Asp Ala Asn Ser Ser Phe Phe Asp 
            260                 265                 270         


Asn Ser Ser Ser Pro His Leu Leu Asp Gln Leu Lys Ala Gln Asn Gln 
        275                 280                 285             


Glu Leu Arg Asn Lys Ile Asn Glu Leu Glu Leu Arg Leu Gln Gly His 
    290                 295                 300                 


Glu Lys Glu Met Lys Gly Gln Val Asn Lys Phe Gln Glu Leu Gln Leu 
305                 310                 315                 320 


Gln Leu Glu Lys Ala Lys Val Glu Leu Ile Glu Lys Glu Lys Val Leu 
                325                 330                 335     


Asn Lys Cys Arg Asp Glu Leu Val Arg Thr Thr Ala Gln Tyr Asp Gln 
            340                 345                 350         


Ala Ser Thr Lys Tyr Thr Ala Leu Glu Gln Lys Leu Lys Lys Leu Thr 
        355                 360                 365             


Glu Asp Leu Ser Cys Gln Arg Gln Asn Ala Glu Ser Ala Arg Cys Ser 
    370                 375                 380                 


Leu Glu Gln Lys Ile Lys Glu Lys Glu Lys Glu Phe Gln Glu Glu Leu 
385                 390                 395                 400 


Ser Arg Gln Gln Arg Ser Phe Gln Thr Leu Asp Gln Glu Cys Ile Gln 
                405                 410                 415     


Met Lys Ala Arg Leu Thr Gln Glu Leu Gln Gln Ala Lys Asn Met His 
            420                 425                 430         


Asn Val Leu Gln Ala Glu Leu Asp Lys Leu Thr Ser Val Lys Gln Gln 
        435                 440                 445             


Leu Glu Asn Asn Leu Glu Glu Phe Lys Gln Lys Leu Cys Arg Ala Glu 
    450                 455                 460                 


Gln Ala Phe Gln Ala Ser Gln Ile Lys Glu Asn Glu Leu Arg Arg Ser 
465                 470                 475                 480 


Met Glu Glu Met Lys Lys Glu Asn Asn Leu Leu Lys Ser His Ser Glu 
                485                 490                 495     


Gln Lys Ala Arg Glu Val Cys His Leu Glu Ala Glu Leu Lys Asn Ile 
            500                 505                 510         


Lys Gln Cys Leu Asn Gln Ser Gln Asn Phe Ala Glu Glu Met Lys Ala 
        515                 520                 525             


Lys Asn Thr Ser Gln Glu Thr Met Leu Arg Asp Leu Gln Glu Lys Ile 
    530                 535                 540                 


Asn Gln Gln Glu Asn Ser Leu Thr Leu Glu Lys Leu Lys Leu Ala Val 
545                 550                 555                 560 


Ala Asp Leu Glu Lys Gln Arg Asp Cys Ser Gln Asp Leu Leu Lys Lys 
                565                 570                 575     


Arg Glu His His Ile Glu Gln Leu Asn Asp Lys Leu Ser Lys Thr Glu 
            580                 585                 590         


Lys Glu Ser Lys Ala Leu Leu Ser Ala Leu Glu Leu Lys Lys Lys Glu 
        595                 600                 605             


Tyr Glu Glu Leu Lys Glu Glu Lys Thr Leu Phe Ser Cys Trp Lys Ser 
    610                 615                 620                 


Glu Asn Glu Lys Leu Leu Thr Gln Met Glu Ser Glu Lys Glu Asn Leu 
625                 630                 635                 640 


Gln Ser Lys Ile Asn His Leu Glu Thr Cys Leu Lys Thr Gln Gln Ile 
                645                 650                 655     


Lys Ser His Glu Tyr Asn Glu Arg Val Arg Thr Leu Glu Met Asp Arg 
            660                 665                 670         


Glu Asn Leu Ser Val Glu Ile Arg Asn Leu His Asn Val Leu Asp Ser 
        675                 680                 685             


Lys Ser Val Glu Val Glu Thr Gln Lys Leu Ala Tyr Met Glu Leu Gln 
    690                 695                 700                 


Gln Lys Ala Glu Phe Ser Asp Gln Lys His Gln Lys Glu Ile Glu Asn 
705                 710                 715                 720 


Met Cys Leu Lys Thr Ser Gln Leu Thr Gly Gln Val Glu Asp Leu Glu 
                725                 730                 735     


His Lys Leu Gln Leu Leu Ser Asn Glu Ile Met Asp Lys Asp Arg Cys 
            740                 745                 750         


Tyr Gln Asp Leu His Ala Glu Tyr Glu Ser Leu Arg Asp Leu Leu Lys 
        755                 760                 765             


Ser Lys Asp Ala Ser Leu Val Thr Asn Glu Asp His Gln Arg Ser Leu 
    770                 775                 780                 


Leu Ala Phe Asp Gln Gln Pro Ala Met His His Ser Phe Ala Asn Ile 
785                 790                 795                 800 


Ile Gly Glu Gln Gly Ser Met Pro Ser Glu Arg Ser Glu Cys Arg Leu 
                805                 810                 815     


Glu Ala Asp Gln Ser Pro Lys Asn Ser Ala Ile Leu Gln Asn Arg Val 
            820                 825                 830         


Asp Ser Leu Glu Phe Ser Leu Glu Ser Gln Lys Gln Met Asn Ser Asp 
        835                 840                 845             


Leu Gln Lys Gln Cys Glu Glu Leu Val Gln Ile Lys Gly Glu Ile Glu 
    850                 855                 860                 


Glu Asn Leu Met Lys Ala Glu Gln Met His Gln Ser Phe Val Ala Glu 
865                 870                 875                 880 


Thr Ser Gln Arg Ile Ser Lys Leu Gln Glu Asp Thr Ser Ala His Gln 
                885                 890                 895     


Asn Val Val Ala Glu Thr Leu Ser Ala Leu Glu Asn Lys Glu Lys Glu 
            900                 905                 910         


Leu Gln Leu Leu Asn Asp Lys Val Glu Thr Glu Gln Ala Glu Ile Gln 
        915                 920                 925             


Glu Leu Lys Lys Ser Asn His Leu Leu Glu Asp Ser Leu Lys Glu Leu 
    930                 935                 940                 


Gln Leu Leu Ser Glu Thr Leu Ser Leu Glu Lys Lys Glu Met Ser Ser 
945                 950                 955                 960 


Ile Ile Ser Leu Asn Lys Arg Glu Ile Glu Glu Leu Thr Gln Glu Asn 
                965                 970                 975     


Gly Thr Leu Lys Glu Ile Asn Ala Ser Leu Asn Gln Glu Lys Met Asn 
            980                 985                 990         


Leu Ile Gln Lys Ser Glu Ser Phe  Ala Asn Tyr Ile Asp  Glu Arg Glu 
        995                 1000                 1005             


Lys Ser  Ile Ser Glu Leu Ser  Asp Gln Tyr Lys Gln  Glu Lys Leu 
    1010                 1015                 1020             


Ile Leu  Leu Gln Arg Cys Glu  Glu Thr Gly Asn Ala  Tyr Glu Asp 
    1025                 1030                 1035             


Leu Ser  Gln Lys Tyr Lys Ala  Ala Gln Glu Lys Asn  Ser Lys Leu 
    1040                 1045                 1050             


Glu Cys  Leu Leu Asn Glu Cys  Thr Ser Leu Cys Glu  Asn Arg Lys 
    1055                 1060                 1065             


Asn Glu  Leu Glu Gln Leu Lys  Glu Ala Phe Ala Lys  Glu His Gln 
    1070                 1075                 1080             


Glu Phe  Leu Thr Lys Leu Ala  Phe Ala Glu Glu Arg  Asn Gln Asn 
    1085                 1090                 1095             


Leu Met  Leu Glu Leu Glu Thr  Val Gln Gln Ala Leu  Arg Ser Glu 
    1100                 1105                 1110             


Met Thr  Asp Asn Gln Asn Asn  Ser Lys Ser Glu Ala  Gly Gly Leu 
    1115                 1120                 1125             


Lys Gln  Glu Ile Met Thr Leu  Lys Glu Glu Gln Asn  Lys Met Gln 
    1130                 1135                 1140             


Lys Glu  Val Asn Asp Leu Leu  Gln Glu Asn Glu Gln  Leu Met Lys 
    1145                 1150                 1155             


Val Met  Lys Thr Lys His Glu  Cys Gln Asn Leu Glu  Ser Glu Pro 
    1160                 1165                 1170             


Ile Arg  Asn Ser Val Lys Glu  Arg Glu Ser Glu Arg  Asn Gln Cys 
    1175                 1180                 1185             


Asn Phe  Lys Pro Gln Met Asp  Leu Glu Val Lys Glu  Ile Ser Leu 
    1190                 1195                 1200             


Asp Ser  Tyr Asn Ala Gln Leu  Val Gln Leu Glu Ala  Met Leu Arg 
    1205                 1210                 1215             


Asn Lys  Glu Leu Lys Leu Gln  Glu Ser Glu Lys Glu  Lys Glu Cys 
    1220                 1225                 1230             


Leu Gln  His Glu Leu Gln Thr  Ile Arg Gly Asp Leu  Glu Thr Ser 
    1235                 1240                 1245             


Asn Leu  Gln Asp Met Gln Ser  Gln Glu Ile Ser Gly  Leu Lys Asp 
    1250                 1255                 1260             


Cys Glu  Ile Asp Ala Glu Glu  Lys Tyr Ile Ser Gly  Pro His Glu 
    1265                 1270                 1275             


Leu Ser  Thr Ser Gln Asn Asp  Asn Ala His Leu Gln  Cys Ser Leu 
    1280                 1285                 1290             


Gln Thr  Thr Met Asn Lys Leu  Asn Glu Leu Glu Lys  Ile Cys Glu 
    1295                 1300                 1305             


Ile Leu  Gln Ala Glu Lys Tyr  Glu Leu Val Thr Glu  Leu Asn Asp 
    1310                 1315                 1320             


Ser Arg  Ser Glu Cys Ile Thr  Ala Thr Arg Lys Met  Ala Glu Glu 
    1325                 1330                 1335             


Val Gly  Lys Leu Leu Asn Glu  Val Lys Ile Leu Asn  Asp Asp Ser 
    1340                 1345                 1350             


Gly Leu  Leu His Gly Glu Leu  Val Glu Asp Ile Pro  Gly Gly Glu 
    1355                 1360                 1365             


Phe Gly  Glu Gln Pro Asn Glu  Gln His Pro Val Ser  Leu Ala Pro 
    1370                 1375                 1380             


Leu Asp  Glu Ser Asn Ser Tyr  Glu His Leu Thr Leu  Ser Asp Lys 
    1385                 1390                 1395             


Glu Val  Gln Met His Phe Ala  Glu Leu Gln Glu Lys  Phe Leu Ser 
    1400                 1405                 1410             


Leu Gln  Ser Glu His Lys Ile  Leu His Asp Gln His  Cys Gln Met 
    1415                 1420                 1425             


Ser Ser  Lys Met Ser Glu Leu  Gln Thr Tyr Val Asp  Ser Leu Lys 
    1430                 1435                 1440             


Ala Glu  Asn Leu Val Leu Ser  Thr Asn Leu Arg Asn  Phe Gln Gly 
    1445                 1450                 1455             


Asp Leu  Val Lys Glu Met Gln  Leu Gly Leu Glu Glu  Gly Leu Val 
    1460                 1465                 1470             


Pro Ser  Leu Ser Ser Ser Cys  Val Pro Asp Ser Ser  Ser Leu Ser 
    1475                 1480                 1485             


Ser Leu  Gly Asp Ser Ser Phe  Tyr Arg Ala Leu Leu  Glu Gln Thr 
    1490                 1495                 1500             


Gly Asp  Met Ser Leu Leu Ser  Asn Leu Glu Gly Ala  Val Ser Ala 
    1505                 1510                 1515             


Asn Gln  Cys Ser Val Asp Glu  Val Phe Cys Ser Ser  Leu Gln Glu 
    1520                 1525                 1530             


Glu Asn  Leu Thr Arg Lys Glu  Thr Pro Ser Ala Pro  Ala Lys Gly 
    1535                 1540                 1545             


Val Glu  Glu Leu Glu Ser Leu  Cys Glu Val Tyr Arg  Gln Ser Leu 
    1550                 1555                 1560             


Glu Lys  Leu Glu Glu Lys Met  Glu Ser Gln Gly Ile  Met Lys Asn 
    1565                 1570                 1575             


Lys Glu  Ile Gln Glu Leu Glu  Gln Leu Leu Ser Ser  Glu Arg Gln 
    1580                 1585                 1590             


Glu Leu  Asp Cys Leu Arg Lys  Gln Tyr Leu Ser Glu  Asn Glu Gln 
    1595                 1600                 1605             


Trp Gln  Gln Lys Leu Thr Ser  Val Thr Leu Glu Met  Glu Ser Lys 
    1610                 1615                 1620             


Leu Ala  Ala Glu Lys Lys Gln  Thr Glu Gln Leu Ser  Leu Glu Leu 
    1625                 1630                 1635             


Glu Val  Ala Arg Leu Gln Leu  Gln Gly Leu Asp Leu  Ser Ser Arg 
    1640                 1645                 1650             


Ser Leu  Leu Gly Ile Asp Thr  Glu Asp Ala Ile Gln  Gly Arg Asn 
    1655                 1660                 1665             


Glu Ser  Cys Asp Ile Ser Lys  Glu His Thr Ser Glu  Thr Thr Glu 
    1670                 1675                 1680             


Arg Thr  Pro Lys His Asp Val  His Gln Ile Cys Asp  Lys Asp Ala 
    1685                 1690                 1695             


Gln Gln  Asp Leu Asn Leu Asp  Ile Glu Lys Ile Thr  Glu Thr Gly 
    1700                 1705                 1710             


Ala Val  Lys Pro Thr Gly Glu  Cys Ser Gly Glu Gln  Ser Pro Asp 
    1715                 1720                 1725             


Thr Asn  Tyr Glu Pro Pro Gly  Glu Asp Lys Thr Gln  Gly Ser Ser 
    1730                 1735                 1740             


Glu Cys  Ile Ser Glu Leu Ser  Phe Ser Gly Pro Asn  Ala Leu Val 
    1745                 1750                 1755             


Pro Met  Asp Phe Leu Gly Asn  Gln Glu Asp Ile His  Asn Leu Gln 
    1760                 1765                 1770             


Leu Arg  Val Lys Glu Thr Ser  Asn Glu Asn Leu Arg  Leu Leu His 
    1775                 1780                 1785             


Val Ile  Glu Asp Arg Asp Arg  Lys Val Glu Ser Leu  Leu Asn Glu 
    1790                 1795                 1800             


Met Lys  Glu Leu Asp Ser Lys  Leu His Leu Gln Glu  Val Gln Leu 
    1805                 1810                 1815             


Met Thr  Lys Ile Glu Ala Cys  Ile Glu Leu Glu Lys  Ile Val Gly 
    1820                 1825                 1830             


Glu Leu  Lys Lys Glu Asn Ser  Asp Leu Ser Glu Lys  Leu Glu Tyr 
    1835                 1840                 1845             


Phe Ser  Cys Asp His Gln Glu  Leu Leu Gln Arg Val  Glu Thr Ser 
    1850                 1855                 1860             


Glu Gly  Leu Asn Ser Asp Leu  Glu Met His Ala Asp  Lys Ser Ser 
    1865                 1870                 1875             


Arg Glu  Asp Ile Gly Asp Asn  Val Ala Lys Val Asn  Asp Ser Trp 
    1880                 1885                 1890             


Lys Glu  Arg Phe Leu Asp Val  Glu Asn Glu Leu Ser  Arg Ile Arg 
    1895                 1900                 1905             


Ser Glu  Lys Ala Ser Ile Glu  His Glu Ala Leu Tyr  Leu Glu Ala 
    1910                 1915                 1920             


Asp Leu  Glu Val Val Gln Thr  Glu Lys Leu Cys Leu  Glu Lys Asp 
    1925                 1930                 1935             


Asn Glu  Asn Lys Gln Lys Val  Ile Val Cys Leu Glu  Glu Glu Leu 
    1940                 1945                 1950             


Ser Val  Val Thr Ser Glu Arg  Asn Gln Leu Arg Gly  Glu Leu Asp 
    1955                 1960                 1965             


Thr Met  Ser Lys Lys Thr Thr  Ala Leu Asp Gln Leu  Ser Glu Lys 
    1970                 1975                 1980             


Met Lys  Glu Lys Thr Gln Glu  Leu Glu Ser His Gln  Ser Glu Cys 
    1985                 1990                 1995             


Leu His  Cys Ile Gln Val Ala  Glu Ala Glu Val Lys  Glu Lys Thr 
    2000                 2005                 2010             


Glu Leu  Leu Gln Thr Leu Ser  Ser Asp Val Ser Glu  Leu Leu Lys 
    2015                 2020                 2025             


Asp Lys  Thr His Leu Gln Glu  Lys Leu Gln Ser Leu  Glu Lys Asp 
    2030                 2035                 2040             


Ser Gln  Ala Leu Ser Leu Thr  Lys Cys Glu Leu Glu  Asn Gln Ile 
    2045                 2050                 2055             


Ala Gln  Leu Asn Lys Glu Lys  Glu Leu Leu Val Lys  Glu Ser Glu 
    2060                 2065                 2070             


Ser Leu  Gln Ala Arg Leu Ser  Glu Ser Asp Tyr Glu  Lys Leu Asn 
    2075                 2080                 2085             


Val Ser  Lys Ala Leu Glu Ala  Ala Leu Val Glu Lys  Gly Glu Phe 
    2090                 2095                 2100             


Ala Leu  Arg Leu Ser Ser Thr  Gln Glu Glu Val His  Gln Leu Arg 
    2105                 2110                 2115             


Arg Gly  Ile Glu Lys Leu Arg  Val Arg Ile Glu Ala  Asp Glu Lys 
    2120                 2125                 2130             


Lys Gln  Leu His Ile Ala Glu  Lys Leu Lys Glu Arg  Glu Arg Glu 
    2135                 2140                 2145             


Asn Asp  Ser Leu Lys Asp Lys  Val Glu Asn Leu Glu  Arg Glu Leu 
    2150                 2155                 2160             


Gln Met  Ser Glu Glu Asn Gln  Glu Leu Val Ile Leu  Asp Ala Glu 
    2165                 2170                 2175             


Asn Ser  Lys Ala Glu Val Glu  Thr Leu Lys Thr Gln  Ile Glu Glu 
    2180                 2185                 2190             


Met Ala  Arg Ser Leu Lys Val  Phe Glu Leu Asp Leu  Val Thr Leu 
    2195                 2200                 2205             


Arg Ser  Glu Lys Glu Asn Leu  Thr Lys Gln Ile Gln  Glu Lys Gln 
    2210                 2215                 2220             


Gly Gln  Leu Ser Glu Leu Asp  Lys Leu Leu Ser Ser  Phe Lys Ser 
    2225                 2230                 2235             


Leu Leu  Glu Glu Lys Glu Gln  Ala Glu Ile Gln Ile  Lys Glu Glu 
    2240                 2245                 2250             


Ser Lys  Thr Ala Val Glu Met  Leu Gln Asn Gln Leu  Lys Glu Leu 
    2255                 2260                 2265             


Asn Glu  Ala Val Ala Ala Leu  Cys Gly Asp Gln Glu  Ile Met Lys 
    2270                 2275                 2280             


Ala Thr  Glu Gln Ser Leu Asp  Pro Pro Ile Glu Glu  Glu His Gln 
    2285                 2290                 2295             


Leu Arg  Asn Ser Ile Glu Lys  Leu Arg Ala Arg Leu  Glu Ala Asp 
    2300                 2305                 2310             


Glu Lys  Lys Gln Leu Cys Val  Leu Gln Gln Leu Lys  Glu Ser Glu 
    2315                 2320                 2325             


His His  Ala Asp Leu Leu Lys  Gly Arg Val Glu Asn  Leu Glu Arg 
    2330                 2335                 2340             


Glu Leu  Glu Ile Ala Arg Thr  Asn Gln Glu His Ala  Ala Leu Glu 
    2345                 2350                 2355             


Ala Glu  Asn Ser Lys Gly Glu  Val Glu Thr Leu Lys  Ala Lys Ile 
    2360                 2365                 2370             


Glu Gly  Met Thr Gln Ser Leu  Arg Gly Leu Glu Leu  Asp Val Val 
    2375                 2380                 2385             


Thr Ile  Arg Ser Glu Lys Glu  Asn Leu Thr Asn Glu  Leu Gln Lys 
    2390                 2395                 2400             


Glu Gln  Glu Arg Ile Ser Glu  Leu Glu Ile Ile Asn  Ser Ser Phe 
    2405                 2410                 2415             


Glu Asn  Ile Leu Gln Glu Lys  Glu Gln Glu Lys Val  Gln Met Lys 
    2420                 2425                 2430             


Glu Lys  Ser Ser Thr Ala Met  Glu Met Leu Gln Thr  Gln Leu Lys 
    2435                 2440                 2445             


Glu Leu  Asn Glu Arg Val Ala  Ala Leu His Asn Asp  Gln Glu Ala 
    2450                 2455                 2460             


Cys Lys  Ala Lys Glu Gln Asn  Leu Ser Ser Gln Val  Glu Cys Leu 
    2465                 2470                 2475             


Glu Leu  Glu Lys Ala Gln Leu  Leu Gln Gly Leu Asp  Glu Ala Lys 
    2480                 2485                 2490             


Asn Asn  Tyr Ile Val Leu Gln  Ser Ser Val Asn Gly  Leu Ile Gln 
    2495                 2500                 2505             


Glu Val  Glu Asp Gly Lys Gln  Lys Leu Glu Lys Lys  Asp Glu Glu 
    2510                 2515                 2520             


Ile Ser  Arg Leu Lys Asn Gln  Ile Gln Asp Gln Glu  Gln Leu Val 
    2525                 2530                 2535             


Ser Lys  Leu Ser Gln Val Glu  Gly Glu His Gln Leu  Trp Lys Glu 
    2540                 2545                 2550             


Gln Asn  Leu Glu Leu Arg Asn  Leu Thr Val Glu Leu  Glu Gln Lys 
    2555                 2560                 2565             


Ile Gln  Val Leu Gln Ser Lys  Asn Ala Ser Leu Gln  Asp Thr Leu 
    2570                 2575                 2580             


Glu Val  Leu Gln Ser Ser Tyr  Lys Asn Leu Glu Asn  Glu Leu Glu 
    2585                 2590                 2595             


Leu Thr  Lys Met Asp Lys Met  Ser Phe Val Glu Lys  Val Asn Lys 
    2600                 2605                 2610             


Met Thr  Ala Lys Glu Thr Glu  Leu Gln Arg Glu Met  His Glu Met 
    2615                 2620                 2625             


Ala Gln  Lys Thr Ala Glu Leu  Gln Glu Glu Leu Ser  Gly Glu Lys 
    2630                 2635                 2640             


Asn Arg  Leu Ala Gly Glu Leu  Gln Leu Leu Leu Glu  Glu Ile Lys 
    2645                 2650                 2655             


Ser Ser  Lys Asp Gln Leu Lys  Glu Leu Thr Leu Glu  Asn Ser Glu 
    2660                 2665                 2670             


Leu Lys  Lys Ser Leu Asp Cys  Met His Lys Asp Gln  Val Glu Lys 
    2675                 2680                 2685             


Glu Gly  Lys Val Arg Glu Glu  Ile Ala Glu Tyr Gln  Leu Arg Leu 
    2690                 2695                 2700             


His Glu  Ala Glu Lys Lys His  Gln Ala Leu Leu Leu  Asp Thr Asn 
    2705                 2710                 2715             


Lys Gln  Tyr Glu Val Glu Ile  Gln Thr Tyr Arg Glu  Lys Leu Thr 
    2720                 2725                 2730             


Ser Lys  Glu Glu Cys Leu Ser  Ser Gln Lys Leu Glu  Ile Asp Leu 
    2735                 2740                 2745             


Leu Lys  Ser Ser Lys Glu Glu  Leu Asn Asn Ser Leu  Lys Ala Thr 
    2750                 2755                 2760             


Thr Gln  Ile Leu Glu Glu Leu  Lys Lys Thr Lys Met  Asp Asn Leu 
    2765                 2770                 2775             


Lys Tyr  Val Asn Gln Leu Lys  Lys Glu Asn Glu Arg  Ala Gln Gly 
    2780                 2785                 2790             


Lys Met  Lys Leu Leu Ile Lys  Ser Cys Lys Gln Leu  Glu Glu Glu 
    2795                 2800                 2805             


Lys Glu  Ile Leu Gln Lys Glu  Leu Ser Gln Leu Gln  Ala Ala Gln 
    2810                 2815                 2820             


Glu Lys  Gln Lys Thr Gly Thr  Val Met Asp Thr Lys  Val Asp Glu 
    2825                 2830                 2835             


Leu Thr  Thr Glu Ile Lys Glu  Leu Lys Glu Thr Leu  Glu Glu Lys 
    2840                 2845                 2850             


Thr Lys  Glu Ala Asp Glu Tyr  Leu Asp Lys Tyr Cys  Ser Leu Leu 
    2855                 2860                 2865             


Ile Ser  His Glu Lys Leu Glu  Lys Ala Lys Glu Met  Leu Glu Thr 
    2870                 2875                 2880             


Gln Val  Ala His Leu Cys Ser  Gln Gln Ser Lys Gln  Asp Ser Arg 
    2885                 2890                 2895             


Gly Ser  Pro Leu Leu Gly Pro  Val Val Pro Gly Pro  Ser Pro Ile 
    2900                 2905                 2910             


Pro Ser  Val Thr Glu Lys Arg  Leu Ser Ser Gly Gln  Asn Lys Ala 
    2915                 2920                 2925             


Ser Gly  Lys Arg Gln Arg Ser  Ser Gly Ile Trp Glu  Asn Gly Arg 
    2930                 2935                 2940             


Gly Pro  Thr Pro Ala Thr Pro  Glu Ser Phe Ser Lys  Lys Ser Lys 
    2945                 2950                 2955             


Lys Ala  Val Met Ser Gly Ile  His Pro Ala Glu Asp  Thr Glu Gly 
    2960                 2965                 2970             


Thr Glu  Phe Glu Pro Glu Gly  Leu Pro Glu Val Val  Lys Lys Gly 
    2975                 2980                 2985             


Phe Ala  Asp Ile Pro Thr Gly  Lys Thr Ser Pro Tyr  Ile Leu Arg 
    2990                 2995                 3000             


Arg Thr  Thr Met Ala Thr Arg  Thr Ser Pro Arg Leu  Ala Ala Gln 
    3005                 3010                 3015             


Lys Leu  Ala Leu Ser Pro Leu  Ser Leu Gly Lys Glu  Asn Leu Ala 
    3020                 3025                 3030             


Glu Ser  Ser Lys Pro Thr Ala  Gly Gly Ser Arg Ser  Gln Lys Val 
    3035                 3040                 3045             


Lys Val  Ala Gln Arg Ser Pro  Val Asp Ser Gly Thr  Ile Leu Arg 
    3050                 3055                 3060             


Glu Pro  Thr Thr Lys Ser Val  Pro Val Asn Asn Leu  Pro Glu Arg 
    3065                 3070                 3075             


Ser Pro  Thr Asp Ser Pro Arg  Glu Gly Leu Arg Val  Lys Arg Gly 
    3080                 3085                 3090             


Arg Leu  Val Pro Ser Pro Lys  Ala Gly Leu Glu Ser  Asn Gly Ser 
    3095                 3100                 3105             


Glu Asn  Cys Lys Val Gln 
    3110                 


<210>  73
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Pro Ser Ser Leu Pro Gly Ser Gln Val Pro His Pro Thr Leu Asp 
1               5                   10                  15      


Ala Val Asp Leu Val Glu Lys Thr Leu Arg Asn Glu Gly Thr Ser Ser 
            20                  25                  30          


Ser Ala Pro Val Leu Glu Glu Gly Asp Thr Asp Pro Trp Thr Leu Pro 
        35                  40                  45              


Gln Leu Lys Asp Thr Ser Gln Pro Trp Lys Glu Leu Arg Val Ala Gly 
    50                  55                  60                  


Arg Leu Arg Arg Val Ala Gly Ser Val Leu Lys Ala Cys Gly Leu Leu 
65                  70                  75                  80  


Gly Ser Leu Tyr Phe Phe Ile Cys Ser Leu Asp Val Leu Ser Ser Ala 
                85                  90                  95      


Phe Gln Leu Leu Gly Ser Lys Val Ala Gly Asp Ile Phe Lys Asp Asn 
            100                 105                 110         


Val Val Leu Ser Asn Pro Val Ala Gly Leu Val Ile Gly Val Leu Val 
        115                 120                 125             


Thr Ala Leu Val Gln Ser Ser Ser Thr Ser Ser Ser Ile Val Val Ser 
    130                 135                 140                 


Met Val Ala Ala Lys Leu Leu Thr Val Arg Val Ser Val Pro Ile Ile 
145                 150                 155                 160 


Met Gly Val Asn Val Gly Thr Ser Ile Thr Ser Thr Leu Val Ser Met 
                165                 170                 175     


Ala Gln Ser Gly Asp Arg Asp Glu Phe Gln Arg Ala Phe Ser Gly Ser 
            180                 185                 190         


Ala Val His Gly Ile Phe Asn Trp Leu Thr Val Leu Val Leu Leu Pro 
        195                 200                 205             


Leu Glu Ser Ala Thr Ala Leu Leu Glu Arg Leu Ser Glu Leu Ala Leu 
    210                 215                 220                 


Gly Ala Ala Ser Leu Thr Pro Arg Ala Gln Ala Pro Asp Ile Leu Lys 
225                 230                 235                 240 


Val Leu Thr Lys Pro Leu Thr His Leu Ile Val Gln Leu Asp Ser Asp 
                245                 250                 255     


Met Ile Met Ser Ser Ala Thr Gly Asn Ala Thr Asn Ser Ser Leu Ile 
            260                 265                 270         


Lys His Trp Cys Gly Thr Thr Gly Gln Pro Thr Gln Glu Asn Ser Ser 
        275                 280                 285             


Cys Gly Ala Phe Gly Pro Cys Thr Glu Lys Asn Ser Thr Ala Pro Ala 
    290                 295                 300                 


Asp Arg Leu Pro Cys Arg His Leu Phe Ala Gly Thr Glu Leu Thr Asp 
305                 310                 315                 320 


Leu Ala Val Gly Cys Ile Leu Leu Ala Gly Ser Leu Leu Val Leu Cys 
                325                 330                 335     


Gly Cys Leu Val Leu Ile Val Lys Leu Leu Asn Ser Val Leu Arg Gly 
            340                 345                 350         


Arg Val Ala Gln Val Val Arg Thr Val Ile Asn Ala Asp Phe Pro Phe 
        355                 360                 365             


Pro Leu Gly Trp Leu Gly Gly Tyr Leu Ala Val Leu Ala Gly Ala Gly 
    370                 375                 380                 


Leu Thr Phe Ala Leu Gln Ser Ser Ser Val Phe Thr Ala Ala Val Val 
385                 390                 395                 400 


Pro Leu Met Gly Val Gly Val Ile Ser Leu Asp Arg Ala Tyr Pro Leu 
                405                 410                 415     


Leu Leu Gly Ser Asn Ile Gly Thr Thr Thr Thr Ala Leu Leu Ala Ala 
            420                 425                 430         


Leu Ala Ser Pro Ala Asp Arg Met Leu Ser Ala Leu Gln Val Ala Leu 
        435                 440                 445             


Ile His Phe Phe Phe Asn Leu Ala Gly Ile Leu Leu Trp Tyr Leu Val 
    450                 455                 460                 


Pro Ala Leu Arg Leu Pro Ile Pro Leu Ala Arg His Phe Gly Val Val 
465                 470                 475                 480 


Thr Ala Arg Tyr Arg Trp Val Ala Gly Val Tyr Leu Leu Leu Gly Phe 
                485                 490                 495     


Leu Leu Leu Pro Leu Ala Ala Phe Gly Leu Ser Leu Ala Gly Gly Met 
            500                 505                 510         


Val Leu Ala Ala Val Gly Gly Pro Leu Val Gly Leu Val Leu Leu Val 
        515                 520                 525             


Ile Leu Val Thr Val Leu Gln Arg Arg Arg Pro Ala Trp Leu Pro Val 
    530                 535                 540                 


Arg Leu Arg Ser Trp Ala Trp Leu Pro Val Trp Leu His Ser Leu Glu 
545                 550                 555                 560 


Pro Trp Asp Arg Leu Val Thr Arg Cys Cys Pro Cys Asn Val Cys Ser 
                565                 570                 575     


Pro Pro Lys Ala Thr Thr Lys Glu Ala Tyr Cys Tyr Glu Asn Pro Glu 
            580                 585                 590         


Ile Leu Ala Ser Gln Gln Leu 
        595                 


<210>  74
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Glu Asn Gln Glu Lys Ala Ser Ile Ala Gly His Met Phe Asp Val 
1               5                   10                  15      


Val Val Ile Gly Gly Gly Ile Ser Gly Leu Ser Ala Ala Lys Leu Leu 
            20                  25                  30          


Thr Glu Tyr Gly Val Ser Val Leu Val Leu Glu Ala Arg Asp Arg Val 
        35                  40                  45              


Gly Gly Arg Thr Tyr Thr Ile Arg Asn Glu His Val Asp Tyr Val Asp 
    50                  55                  60                  


Val Gly Gly Ala Tyr Val Gly Pro Thr Gln Asn Arg Ile Leu Arg Leu 
65                  70                  75                  80  


Ser Lys Glu Leu Gly Ile Glu Thr Tyr Lys Val Asn Val Ser Glu Arg 
                85                  90                  95      


Leu Val Gln Tyr Val Lys Gly Lys Thr Tyr Pro Phe Arg Gly Ala Phe 
            100                 105                 110         


Pro Pro Val Trp Asn Pro Ile Ala Tyr Leu Asp Tyr Asn Asn Leu Trp 
        115                 120                 125             


Arg Thr Ile Asp Asn Met Gly Lys Glu Ile Pro Thr Asp Ala Pro Trp 
    130                 135                 140                 


Glu Ala Gln His Ala Asp Lys Trp Asp Lys Met Thr Met Lys Glu Leu 
145                 150                 155                 160 


Ile Asp Lys Ile Cys Trp Thr Lys Thr Ala Arg Arg Phe Ala Tyr Leu 
                165                 170                 175     


Phe Val Asn Ile Asn Val Thr Ser Glu Pro His Glu Val Ser Ala Leu 
            180                 185                 190         


Trp Phe Leu Trp Tyr Val Lys Gln Cys Gly Gly Thr Thr Arg Ile Phe 
        195                 200                 205             


Ser Val Thr Asn Gly Gly Gln Glu Arg Lys Phe Val Gly Gly Ser Gly 
    210                 215                 220                 


Gln Val Ser Glu Arg Ile Met Asp Leu Leu Gly Asp Gln Val Lys Leu 
225                 230                 235                 240 


Asn His Pro Val Thr His Val Asp Gln Ser Ser Asp Asn Ile Ile Ile 
                245                 250                 255     


Glu Thr Leu Asn His Glu His Tyr Glu Cys Lys Tyr Val Ile Asn Ala 
            260                 265                 270         


Ile Pro Pro Thr Leu Thr Ala Lys Ile His Phe Arg Pro Glu Leu Pro 
        275                 280                 285             


Ala Glu Arg Asn Gln Leu Ile Gln Arg Leu Pro Met Gly Ala Val Ile 
    290                 295                 300                 


Lys Cys Met Met Tyr Tyr Lys Glu Ala Phe Trp Lys Lys Lys Asp Tyr 
305                 310                 315                 320 


Cys Gly Cys Met Ile Ile Glu Asp Glu Asp Ala Pro Ile Ser Ile Thr 
                325                 330                 335     


Leu Asp Asp Thr Lys Pro Asp Gly Ser Leu Pro Ala Ile Met Gly Phe 
            340                 345                 350         


Ile Leu Ala Arg Lys Ala Asp Arg Leu Ala Lys Leu His Lys Glu Ile 
        355                 360                 365             


Arg Lys Lys Lys Ile Cys Glu Leu Tyr Ala Lys Val Leu Gly Ser Gln 
    370                 375                 380                 


Glu Ala Leu His Pro Val His Tyr Glu Glu Lys Asn Trp Cys Glu Glu 
385                 390                 395                 400 


Gln Tyr Ser Gly Gly Cys Tyr Thr Ala Tyr Phe Pro Pro Gly Ile Met 
                405                 410                 415     


Thr Gln Tyr Gly Arg Val Ile Arg Gln Pro Val Gly Arg Ile Phe Phe 
            420                 425                 430         


Ala Gly Thr Glu Thr Ala Thr Lys Trp Ser Gly Tyr Met Glu Gly Ala 
        435                 440                 445             


Val Glu Ala Gly Glu Arg Ala Ala Arg Glu Val Leu Asn Gly Leu Gly 
    450                 455                 460                 


Lys Val Thr Glu Lys Asp Ile Trp Val Gln Glu Pro Glu Ser Lys Asp 
465                 470                 475                 480 


Val Pro Ala Val Glu Ile Thr His Thr Phe Trp Glu Arg Asn Leu Pro 
                485                 490                 495     


Ser Val Ser Gly Leu Leu Lys Ile Ile Gly Phe Ser Thr Ser Val Thr 
            500                 505                 510         


Ala Leu Gly Phe Val Leu Tyr Lys Tyr Lys Leu Leu Pro Arg Ser 
        515                 520                 525         


<210>  75
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Thr Met Pro Val Asn Gly Ala His Lys Asp Ala Asp Leu Trp Ser 
1               5                   10                  15      


Ser His Asp Lys Met Leu Ala Gln Pro Leu Lys Asp Ser Asp Val Glu 
            20                  25                  30          


Val Tyr Asn Ile Ile Lys Lys Glu Ser Asn Arg Gln Arg Val Gly Leu 
        35                  40                  45              


Glu Leu Ile Ala Ser Glu Asn Phe Ala Ser Arg Ala Val Leu Glu Ala 
    50                  55                  60                  


Leu Gly Ser Cys Leu Asn Asn Lys Tyr Ser Glu Gly Tyr Pro Gly Gln 
65                  70                  75                  80  


Arg Tyr Tyr Gly Gly Thr Glu Phe Ile Asp Glu Leu Glu Thr Leu Cys 
                85                  90                  95      


Gln Lys Arg Ala Leu Gln Ala Tyr Lys Leu Asp Pro Gln Cys Trp Gly 
            100                 105                 110         


Val Asn Val Gln Pro Tyr Ser Gly Ser Pro Ala Asn Phe Ala Val Tyr 
        115                 120                 125             


Thr Ala Leu Val Glu Pro His Gly Arg Ile Met Gly Leu Asp Leu Pro 
    130                 135                 140                 


Asp Gly Gly His Leu Thr His Gly Phe Met Thr Asp Lys Lys Lys Ile 
145                 150                 155                 160 


Ser Ala Thr Ser Ile Phe Phe Glu Ser Met Pro Tyr Lys Val Asn Pro 
                165                 170                 175     


Asp Thr Gly Tyr Ile Asn Tyr Asp Gln Leu Glu Glu Asn Ala Arg Leu 
            180                 185                 190         


Phe His Pro Lys Leu Ile Ile Ala Gly Thr Ser Cys Tyr Ser Arg Asn 
        195                 200                 205             


Leu Glu Tyr Ala Arg Leu Arg Lys Ile Ala Asp Glu Asn Gly Ala Tyr 
    210                 215                 220                 


Leu Met Ala Asp Met Ala His Ile Ser Gly Leu Val Ala Ala Gly Val 
225                 230                 235                 240 


Val Pro Ser Pro Phe Glu His Cys His Val Val Thr Thr Thr Thr His 
                245                 250                 255     


Lys Thr Leu Arg Gly Cys Arg Ala Gly Met Ile Phe Tyr Arg Lys Gly 
            260                 265                 270         


Val Lys Ser Val Asp Pro Lys Thr Gly Lys Glu Ile Leu Tyr Asn Leu 
        275                 280                 285             


Glu Ser Leu Ile Asn Ser Ala Val Phe Pro Gly Leu Gln Gly Gly Pro 
    290                 295                 300                 


His Asn His Ala Ile Ala Gly Val Ala Val Ala Leu Lys Gln Ala Met 
305                 310                 315                 320 


Thr Leu Glu Phe Lys Val Tyr Gln His Gln Val Val Ala Asn Cys Arg 
                325                 330                 335     


Ala Leu Ser Glu Ala Leu Thr Glu Leu Gly Tyr Lys Ile Val Thr Gly 
            340                 345                 350         


Gly Ser Asp Asn His Leu Ile Leu Val Asp Leu Arg Ser Lys Gly Thr 
        355                 360                 365             


Asp Gly Gly Arg Ala Glu Lys Val Leu Glu Ala Cys Ser Ile Ala Cys 
    370                 375                 380                 


Asn Lys Asn Thr Cys Pro Gly Asp Arg Ser Ala Leu Arg Pro Ser Gly 
385                 390                 395                 400 


Leu Arg Leu Gly Thr Pro Ala Leu Thr Ser Arg Gly Leu Leu Glu Lys 
                405                 410                 415     


Asp Phe Gln Lys Val Ala His Phe Ile His Arg Gly Ile Glu Leu Thr 
            420                 425                 430         


Leu Gln Ile Gln Ser Asp Thr Gly Val Arg Ala Thr Leu Lys Glu Phe 
        435                 440                 445             


Lys Glu Arg Leu Ala Gly Asp Lys Tyr Gln Ala Ala Val Gln Ala Leu 
    450                 455                 460                 


Arg Glu Glu Val Glu Ser Phe Ala Ser Leu Phe Pro Leu Pro Gly Leu 
465                 470                 475                 480 


Pro Asp Phe 
            


<210>  76
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Asp Ser Ala Leu Ser Asp Pro His Asn Gly Ser Ala Glu Ala Gly 
1               5                   10                  15      


Gly Pro Thr Asn Ser Thr Thr Arg Pro Pro Ser Thr Pro Glu Gly Ile 
            20                  25                  30          


Ala Leu Ala Tyr Gly Ser Leu Leu Leu Met Ala Leu Leu Pro Ile Phe 
        35                  40                  45              


Phe Gly Ala Leu Arg Ser Val Arg Cys Ala Arg Gly Lys Asn Ala Ser 
    50                  55                  60                  


Asp Met Pro Glu Thr Ile Thr Ser Arg Asp Ala Ala Arg Phe Pro Ile 
65                  70                  75                  80  


Ile Ala Ser Cys Thr Leu Leu Gly Leu Tyr Leu Phe Phe Lys Ile Phe 
                85                  90                  95      


Ser Gln Glu Tyr Ile Asn Leu Leu Leu Ser Met Tyr Phe Phe Val Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Ser His Thr Ile Ser Pro Phe Met Asn Lys Phe 
        115                 120                 125             


Phe Pro Ala Ser Phe Pro Asn Arg Gln Tyr Gln Leu Leu Phe Thr Gln 
    130                 135                 140                 


Gly Ser Gly Glu Asn Lys Glu Glu Ile Ile Asn Tyr Glu Phe Asp Thr 
145                 150                 155                 160 


Lys Asp Leu Val Cys Leu Gly Leu Ser Ser Ile Val Gly Val Trp Tyr 
                165                 170                 175     


Leu Leu Arg Lys His Trp Ile Ala Asn Asn Leu Phe Gly Leu Ala Phe 
            180                 185                 190         


Ser Leu Asn Gly Val Glu Leu Leu His Leu Asn Asn Val Ser Thr Gly 
        195                 200                 205             


Cys Ile Leu Leu Gly Gly Leu Phe Ile Tyr Asp Val Phe Trp Val Phe 
    210                 215                 220                 


Gly Thr Asn Val Met Val Thr Val Ala Lys Ser Phe Glu Ala Pro Ile 
225                 230                 235                 240 


Lys Leu Val Phe Pro Gln Asp Leu Leu Glu Lys Gly Leu Glu Ala Asn 
                245                 250                 255     


Asn Phe Ala Met Leu Gly Leu Gly Asp Val Val Ile Pro Gly Ile Phe 
            260                 265                 270         


Ile Ala Leu Leu Leu Arg Phe Asp Ile Ser Leu Lys Lys Asn Thr His 
        275                 280                 285             


Thr Tyr Phe Tyr Thr Ser Phe Ala Ala Tyr Ile Phe Gly Leu Gly Leu 
    290                 295                 300                 


Thr Ile Phe Ile Met His Ile Phe Lys His Ala Gln Pro Ala Leu Leu 
305                 310                 315                 320 


Tyr Leu Val Pro Ala Cys Ile Gly Phe Pro Val Leu Val Ala Leu Ala 
                325                 330                 335     


Lys Gly Glu Val Thr Glu Met Phe Ser Tyr Glu Ser Ser Ala Glu Ile 
            340                 345                 350         


Leu Pro His Thr Pro Arg Leu Thr His Phe Pro Thr Val Ser Gly Ser 
        355                 360                 365             


Pro Ala Ser Leu Ala Asp Ser Met Gln Gln Lys Leu Ala Gly Pro Arg 
    370                 375                 380                 


Arg Arg Arg Pro Gln Asn Pro Ser Ala Met 
385                 390                 


<210>  77
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Asp Val Ser Gly Gln Glu Thr Asp Trp Arg Ser Thr Ala Phe Arg 
1               5                   10                  15      


Gln Lys Leu Val Ser Gln Ile Glu Asp Ala Met Arg Lys Ala Gly Val 
            20                  25                  30          


Ala His Ser Lys Ser Ser Lys Asp Met Glu Ser His Val Phe Leu Lys 
        35                  40                  45              


Ala Lys Thr Arg Asp Glu Tyr Leu Ser Leu Val Ala Arg Leu Ile Ile 
    50                  55                  60                  


His Phe Arg Asp Ile His Asn Lys Lys Ser Gln Ala Ser Val Ser Asp 
65                  70                  75                  80  


Pro Met Asn Ala Leu Gln Ser Leu Thr Gly Gly Pro Ala Ala Gly Ala 
                85                  90                  95      


Ala Gly Ile Gly Met Pro Pro Arg Gly Pro Gly Gln Ser Leu Gly Gly 
            100                 105                 110         


Met Gly Ser Leu Gly Ala Met Gly Gln Pro Met Ser Leu Ser Gly Gln 
        115                 120                 125             


Pro Pro Pro Gly Thr Ser Gly Met Ala Pro His Ser Met Ala Val Val 
    130                 135                 140                 


Ser Thr Ala Thr Pro Gln Thr Gln Leu Gln Leu Gln Gln Val Ala Leu 
145                 150                 155                 160 


Gln Gln Gln Gln Gln Gln Gln Gln Phe Gln Gln Gln Gln Gln Ala Ala 
                165                 170                 175     


Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Phe Gln Ala Gln 
            180                 185                 190         


Gln Ser Ala Met Gln Gln Gln Phe Gln Ala Val Val Gln Gln Gln Gln 
        195                 200                 205             


Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln His Leu Ile Lys Leu His 
    210                 215                 220                 


His Gln Asn Gln Gln Gln Ile Gln Gln Gln Gln Gln Gln Leu Gln Arg 
225                 230                 235                 240 


Ile Ala Gln Leu Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Ala Leu Gln Ala Gln Pro Pro Ile Gln Gln 
            260                 265                 270         


Pro Pro Met Gln Gln Pro Gln Pro Pro Pro Ser Gln Ala Leu Pro Gln 
        275                 280                 285             


Gln Leu Gln Gln Met His His Thr Gln His His Gln Pro Pro Pro Gln 
    290                 295                 300                 


Pro Gln Gln Pro Pro Val Ala Gln Asn Gln Pro Ser Gln Leu Pro Pro 
305                 310                 315                 320 


Gln Ser Gln Thr Gln Pro Leu Val Ser Gln Ala Gln Ala Leu Pro Gly 
                325                 330                 335     


Gln Met Leu Tyr Thr Gln Pro Pro Leu Lys Phe Val Arg Ala Pro Met 
            340                 345                 350         


Val Val Gln Gln Pro Pro Val Gln Pro Gln Val Gln Gln Gln Gln Thr 
        355                 360                 365             


Ala Val Gln Thr Ala Gln Ala Ala Gln Met Val Ala Pro Gly Val Gln 
    370                 375                 380                 


Val Ser Gln Ser Ser Leu Pro Met Leu Ser Ser Pro Ser Pro Gly Gln 
385                 390                 395                 400 


Gln Val Gln Thr Pro Gln Ser Met Pro Pro Pro Pro Gln Pro Ser Pro 
                405                 410                 415     


Gln Pro Gly Gln Pro Ser Ser Gln Pro Asn Ser Asn Val Ser Ser Gly 
            420                 425                 430         


Pro Ala Pro Ser Pro Ser Ser Phe Leu Pro Ser Pro Ser Pro Gln Pro 
        435                 440                 445             


Ser Gln Ser Pro Val Thr Ala Arg Thr Pro Gln Asn Phe Ser Val Pro 
    450                 455                 460                 


Ser Pro Gly Pro Leu Asn Thr Pro Val Asn Pro Ser Ser Val Met Ser 
465                 470                 475                 480 


Pro Ala Gly Ser Ser Gln Ala Glu Glu Gln Gln Tyr Leu Asp Lys Leu 
                485                 490                 495     


Lys Gln Leu Ser Lys Tyr Ile Glu Pro Leu Arg Arg Met Ile Asn Lys 
            500                 505                 510         


Ile Asp Lys Asn Glu Asp Arg Lys Lys Asp Leu Ser Lys Met Lys Ser 
        515                 520                 525             


Leu Leu Asp Ile Leu Thr Asp Pro Ser Lys Arg Cys Pro Leu Lys Thr 
    530                 535                 540                 


Leu Gln Lys Cys Glu Ile Ala Leu Glu Lys Leu Lys Asn Asp Met Ala 
545                 550                 555                 560 


Val Pro Thr Pro Pro Pro Pro Pro Val Pro Pro Thr Lys Gln Gln Tyr 
                565                 570                 575     


Leu Cys Gln Pro Leu Leu Asp Ala Val Leu Ala Asn Ile Arg Ser Pro 
            580                 585                 590         


Val Phe Asn His Ser Leu Tyr Arg Thr Phe Val Pro Ala Met Thr Ala 
        595                 600                 605             


Ile His Gly Pro Pro Ile Thr Ala Pro Val Val Cys Thr Arg Lys Arg 
    610                 615                 620                 


Arg Leu Glu Asp Asp Glu Arg Gln Ser Ile Pro Ser Val Leu Gln Gly 
625                 630                 635                 640 


Glu Val Ala Arg Leu Asp Pro Lys Phe Leu Val Asn Leu Asp Pro Ser 
                645                 650                 655     


His Cys Ser Asn Asn Gly Thr Val His Leu Ile Cys Lys Leu Asp Asp 
            660                 665                 670         


Lys Asp Leu Pro Ser Val Pro Pro Leu Glu Leu Ser Val Pro Ala Asp 
        675                 680                 685             


Tyr Pro Ala Gln Ser Pro Leu Trp Ile Asp Arg Gln Trp Gln Tyr Asp 
    690                 695                 700                 


Ala Asn Pro Phe Leu Gln Ser Val His Arg Cys Met Thr Ser Arg Leu 
705                 710                 715                 720 


Leu Gln Leu Pro Asp Lys His Ser Val Thr Ala Leu Leu Asn Thr Trp 
                725                 730                 735     


Ala Gln Ser Val His Gln Ala Cys Leu Ser Ala Ala 
            740                 745             


<210>  78
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Arg Lys Glu Thr Pro Pro Pro Leu Val Pro Pro Ala Ala Arg Glu 
1               5                   10                  15      


Trp Asn Leu Pro Pro Asn Ala Pro Ala Cys Met Glu Arg Gln Leu Glu 
            20                  25                  30          


Ala Ala Arg Tyr Arg Ser Asp Gly Ala Leu Leu Leu Gly Ala Ser Ser 
        35                  40                  45              


Leu Ser Gly Arg Cys Trp Ala Gly Ser Leu Trp Leu Phe Lys Asp Pro 
    50                  55                  60                  


Cys Ala Ala Pro Asn Glu Gly Phe Cys Ser Ala Gly Val Gln Thr Glu 
65                  70                  75                  80  


Ala Gly Val Ala Asp Leu Thr Trp Val Gly Glu Arg Gly Ile Leu Val 
                85                  90                  95      


Ala Ser Asp Ser Gly Ala Val Glu Leu Trp Glu Leu Asp Glu Asn Glu 
            100                 105                 110         


Thr Leu Ile Val Ser Lys Phe Cys Lys Tyr Glu His Asp Asp Ile Val 
        115                 120                 125             


Ser Thr Val Ser Val Leu Ser Ser Gly Thr Gln Ala Val Ser Gly Ser 
    130                 135                 140                 


Lys Asp Ile Cys Ile Lys Val Trp Asp Leu Ala Gln Gln Val Val Leu 
145                 150                 155                 160 


Ser Ser Tyr Arg Ala His Ala Ala Gln Val Thr Cys Val Ala Ala Ser 
                165                 170                 175     


Pro His Lys Asp Ser Val Phe Leu Ser Cys Ser Glu Asp Asn Arg Ile 
            180                 185                 190         


Leu Leu Trp Asp Thr Arg Cys Pro Lys Pro Ala Ser Gln Ile Gly Cys 
        195                 200                 205             


Ser Ala Pro Gly Tyr Leu Pro Thr Ser Leu Ala Trp His Pro Gln Gln 
    210                 215                 220                 


Ser Glu Val Phe Val Phe Gly Asp Glu Asn Gly Thr Val Ser Leu Val 
225                 230                 235                 240 


Asp Thr Lys Ser Thr Ser Cys Val Leu Ser Ser Ala Val His Ser Gln 
                245                 250                 255     


Cys Val Thr Gly Leu Val Phe Ser Pro His Ser Val Pro Phe Leu Ala 
            260                 265                 270         


Ser Leu Ser Glu Asp Cys Ser Leu Ala Val Leu Asp Ser Ser Leu Ser 
        275                 280                 285             


Glu Leu Phe Arg Ser Gln Ala His Arg Asp Phe Val Arg Asp Ala Thr 
    290                 295                 300                 


Trp Ser Pro Leu Asn His Ser Leu Leu Thr Thr Val Gly Trp Asp His 
305                 310                 315                 320 


Gln Val Val His His Val Val Pro Thr Glu Pro Leu Pro Ala Pro Gly 
                325                 330                 335     


Pro Ala Ser Val Thr Glu 
            340         


<210>  79
<211>  1555
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Gly Cys Lys Gly Asp Ala Ser Gly Ala Cys Ala Ala Gly Ala Leu 
1               5                   10                  15      


Pro Val Thr Gly Val Cys Tyr Lys Met Gly Val Leu Val Val Leu Thr 
            20                  25                  30          


Val Leu Trp Leu Phe Ser Ser Val Lys Ala Asp Ser Lys Ala Ile Thr 
        35                  40                  45              


Thr Ser Leu Thr Thr Lys Trp Phe Ser Thr Pro Leu Leu Leu Glu Ala 
    50                  55                  60                  


Ser Glu Phe Leu Ala Glu Asp Ser Gln Glu Lys Phe Trp Asn Phe Val 
65                  70                  75                  80  


Glu Ala Ser Gln Asn Ile Gly Ser Ser Asp His Asp Gly Thr Asp Tyr 
                85                  90                  95      


Ser Tyr Tyr His Ala Ile Leu Glu Ala Ala Phe Gln Phe Leu Ser Pro 
            100                 105                 110         


Leu Gln Gln Asn Leu Phe Lys Phe Cys Leu Ser Leu Arg Ser Tyr Ser 
        115                 120                 125             


Ala Thr Ile Gln Ala Phe Gln Gln Ile Ala Ala Asp Glu Pro Pro Pro 
    130                 135                 140                 


Glu Gly Cys Asn Ser Phe Phe Ser Val His Gly Lys Lys Thr Cys Glu 
145                 150                 155                 160 


Ser Asp Thr Leu Glu Ala Leu Leu Leu Thr Ala Ser Glu Arg Pro Lys 
                165                 170                 175     


Pro Leu Leu Phe Lys Gly Asp His Arg Tyr Pro Ser Ser Asn Pro Glu 
            180                 185                 190         


Ser Pro Val Val Ile Phe Tyr Ser Glu Ile Gly Ser Glu Glu Phe Ser 
        195                 200                 205             


Asn Phe His Arg Gln Leu Ile Ser Lys Ser Asn Ala Gly Lys Ile Asn 
    210                 215                 220                 


Tyr Val Phe Arg His Tyr Ile Phe Asn Pro Arg Lys Glu Pro Val Tyr 
225                 230                 235                 240 


Leu Ser Gly Tyr Gly Val Glu Leu Ala Ile Lys Ser Thr Glu Tyr Lys 
                245                 250                 255     


Ala Lys Asp Asp Thr Gln Val Lys Gly Thr Glu Val Asn Thr Thr Val 
            260                 265                 270         


Ile Gly Glu Asn Asp Pro Ile Asp Glu Val Gln Gly Phe Leu Phe Gly 
        275                 280                 285             


Lys Leu Arg Asp Leu His Pro Asp Leu Glu Gly Gln Leu Lys Glu Leu 
    290                 295                 300                 


Arg Lys His Leu Val Glu Ser Thr Asn Glu Met Ala Pro Leu Lys Val 
305                 310                 315                 320 


Trp Gln Leu Gln Asp Leu Ser Phe Gln Thr Ala Ala Arg Ile Leu Ala 
                325                 330                 335     


Ser Pro Val Glu Leu Ala Leu Val Val Met Lys Asp Leu Ser Gln Asn 
            340                 345                 350         


Phe Pro Thr Lys Ala Arg Ala Ile Thr Lys Thr Ala Val Ser Ser Glu 
        355                 360                 365             


Leu Arg Thr Glu Val Glu Glu Asn Gln Lys Tyr Phe Lys Gly Thr Leu 
    370                 375                 380                 


Gly Leu Gln Pro Gly Asp Ser Ala Leu Phe Ile Asn Gly Leu His Met 
385                 390                 395                 400 


Asp Leu Asp Thr Gln Asp Ile Phe Ser Leu Phe Asp Val Leu Arg Asn 
                405                 410                 415     


Glu Ala Arg Val Met Glu Gly Leu His Arg Leu Gly Ile Glu Gly Leu 
            420                 425                 430         


Ser Leu His Asn Val Leu Lys Leu Asn Ile Gln Pro Ser Glu Ala Asp 
        435                 440                 445             


Tyr Ala Val Asp Ile Arg Ser Pro Ala Ile Ser Trp Val Asn Asn Leu 
    450                 455                 460                 


Glu Val Asp Ser Arg Tyr Asn Ser Trp Pro Ser Ser Leu Gln Glu Leu 
465                 470                 475                 480 


Leu Arg Pro Thr Phe Pro Gly Val Ile Arg Gln Ile Arg Lys Asn Leu 
                485                 490                 495     


His Asn Met Val Phe Ile Val Asp Pro Ala His Glu Thr Thr Ala Glu 
            500                 505                 510         


Leu Met Asn Thr Ala Glu Met Phe Leu Ser Asn His Ile Pro Leu Arg 
        515                 520                 525             


Ile Gly Phe Ile Phe Val Val Asn Asp Ser Glu Asp Val Asp Gly Met 
    530                 535                 540                 


Gln Asp Ala Gly Val Ala Val Leu Arg Ala Tyr Asn Tyr Val Ala Gln 
545                 550                 555                 560 


Glu Val Asp Asp Tyr His Ala Phe Gln Thr Leu Thr His Ile Tyr Asn 
                565                 570                 575     


Lys Val Arg Thr Gly Glu Lys Val Lys Val Glu His Val Val Ser Val 
            580                 585                 590         


Leu Glu Lys Lys Tyr Pro Tyr Val Glu Val Asn Ser Ile Leu Gly Ile 
        595                 600                 605             


Asp Ser Ala Tyr Asp Arg Asn Arg Lys Glu Ala Arg Gly Tyr Tyr Glu 
    610                 615                 620                 


Gln Thr Gly Val Gly Pro Leu Pro Val Val Leu Phe Asn Gly Met Pro 
625                 630                 635                 640 


Phe Glu Arg Glu Gln Leu Asp Pro Asp Glu Leu Glu Thr Ile Thr Met 
                645                 650                 655     


His Lys Ile Leu Glu Thr Thr Thr Phe Phe Gln Arg Ala Val Tyr Leu 
            660                 665                 670         


Gly Glu Leu Pro His Asp Gln Asp Val Val Glu Tyr Ile Met Asn Gln 
        675                 680                 685             


Pro Asn Val Val Pro Arg Ile Asn Ser Arg Ile Leu Thr Ala Glu Arg 
    690                 695                 700                 


Asp Tyr Leu Asp Leu Thr Ala Ser Asn Asn Phe Phe Val Asp Asp Tyr 
705                 710                 715                 720 


Ala Arg Phe Thr Ile Leu Asp Ser Gln Gly Lys Thr Ala Ala Val Ala 
                725                 730                 735     


Asn Ser Met Asn Tyr Leu Thr Lys Lys Gly Met Ser Ser Lys Glu Ile 
            740                 745                 750         


Tyr Asp Asp Ser Phe Ile Arg Pro Val Thr Phe Trp Ile Val Gly Asp 
        755                 760                 765             


Phe Asp Ser Pro Ser Gly Arg Gln Leu Leu Tyr Asp Ala Ile Lys His 
    770                 775                 780                 


Gln Lys Ser Ser Asn Asn Val Arg Ile Ser Met Ile Asn Asn Pro Ala 
785                 790                 795                 800 


Lys Glu Ile Ser Tyr Glu Asn Thr Gln Ile Ser Arg Ala Ile Trp Ala 
                805                 810                 815     


Ala Leu Gln Thr Gln Thr Ser Asn Ala Ala Lys Asn Phe Ile Thr Lys 
            820                 825                 830         


Met Ala Lys Glu Gly Ala Ala Glu Ala Leu Ala Ala Gly Ala Asp Ile 
        835                 840                 845             


Ala Glu Phe Ser Val Gly Gly Met Asp Phe Ser Leu Phe Lys Glu Val 
    850                 855                 860                 


Phe Glu Ser Ser Lys Met Asp Phe Ile Leu Ser His Ala Val Tyr Cys 
865                 870                 875                 880 


Arg Asp Val Leu Lys Leu Lys Lys Gly Gln Arg Ala Val Ile Ser Asn 
                885                 890                 895     


Gly Arg Ile Ile Gly Pro Leu Glu Asp Ser Glu Leu Phe Asn Gln Asp 
            900                 905                 910         


Asp Phe His Leu Leu Glu Asn Ile Ile Leu Lys Thr Ser Gly Gln Lys 
        915                 920                 925             


Ile Lys Ser His Ile Gln Gln Leu Arg Val Glu Glu Asp Val Ala Ser 
    930                 935                 940                 


Asp Leu Val Met Lys Val Asp Ala Leu Leu Ser Ala Gln Pro Lys Gly 
945                 950                 955                 960 


Asp Pro Arg Ile Glu Tyr Gln Phe Phe Glu Asp Arg His Ser Ala Ile 
                965                 970                 975     


Lys Leu Arg Pro Lys Glu Gly Glu Thr Tyr Phe Asp Val Val Ala Val 
            980                 985                 990         


Val Asp Pro Val Thr Arg Glu Ala  Gln Arg Leu Ala Pro  Leu Leu Leu 
        995                 1000                 1005             


Val Leu  Ala Gln Leu Ile Asn  Met Asn Leu Arg Val  Phe Met Asn 
    1010                 1015                 1020             


Cys Gln  Ser Lys Leu Ser Asp  Met Pro Leu Lys Ser  Phe Tyr Arg 
    1025                 1030                 1035             


Tyr Val  Leu Glu Pro Glu Ile  Ser Phe Thr Ser Asp  Asn Ser Phe 
    1040                 1045                 1050             


Ala Lys  Gly Pro Ile Ala Lys  Phe Leu Asp Met Pro  Gln Ser Pro 
    1055                 1060                 1065             


Leu Phe  Thr Leu Asn Leu Asn  Thr Pro Glu Ser Trp  Met Val Glu 
    1070                 1075                 1080             


Ser Val  Arg Thr Pro Tyr Asp  Leu Asp Asn Ile Tyr  Leu Glu Glu 
    1085                 1090                 1095             


Val Asp  Ser Val Val Ala Ala  Glu Tyr Glu Leu Glu  Tyr Leu Leu 
    1100                 1105                 1110             


Leu Glu  Gly His Cys Tyr Asp  Ile Thr Thr Gly Gln  Pro Pro Arg 
    1115                 1120                 1125             


Gly Leu  Gln Phe Thr Leu Gly  Thr Ser Ala Asn Pro  Val Ile Val 
    1130                 1135                 1140             


Asp Thr  Ile Val Met Ala Asn  Leu Gly Tyr Phe Gln  Leu Lys Ala 
    1145                 1150                 1155             


Asn Pro  Gly Ala Trp Ile Leu  Arg Leu Arg Lys Gly  Arg Ser Glu 
    1160                 1165                 1170             


Asp Ile  Tyr Arg Ile Tyr Ser  His Asp Gly Thr Asp  Ser Pro Pro 
    1175                 1180                 1185             


Asp Ala  Asp Glu Val Val Ile  Val Leu Asn Asn Phe  Lys Ser Lys 
    1190                 1195                 1200             


Ile Ile  Lys Val Lys Val Gln  Lys Lys Ala Asp Met  Val Asn Glu 
    1205                 1210                 1215             


Asp Leu  Leu Ser Asp Gly Thr  Ser Glu Asn Glu Ser  Gly Phe Trp 
    1220                 1225                 1230             


Asp Ser  Phe Lys Trp Gly Phe  Thr Gly Gln Lys Thr  Glu Glu Val 
    1235                 1240                 1245             


Lys Gln  Asp Lys Asp Asp Ile  Ile Asn Ile Phe Ser  Val Ala Ser 
    1250                 1255                 1260             


Gly His  Leu Tyr Glu Arg Phe  Leu Arg Ile Met Met  Leu Ser Val 
    1265                 1270                 1275             


Leu Lys  Asn Thr Lys Thr Pro  Val Lys Phe Trp Phe  Leu Lys Asn 
    1280                 1285                 1290             


Tyr Leu  Ser Pro Thr Phe Lys  Glu Phe Ile Pro Tyr  Met Ala Asn 
    1295                 1300                 1305             


Glu Tyr  Asn Phe Gln Tyr Glu  Leu Val Gln Tyr Lys  Trp Pro Arg 
    1310                 1315                 1320             


Trp Leu  His Gln Gln Thr Glu  Lys Gln Arg Ile Ile  Trp Gly Tyr 
    1325                 1330                 1335             


Lys Ile  Leu Phe Leu Asp Val  Leu Phe Pro Leu Val  Val Asp Lys 
    1340                 1345                 1350             


Phe Leu  Phe Val Asp Ala Asp  Gln Ile Val Arg Thr  Asp Leu Lys 
    1355                 1360                 1365             


Glu Leu  Arg Asp Phe Asn Leu  Asp Gly Ala Pro Tyr  Gly Tyr Thr 
    1370                 1375                 1380             


Pro Phe  Cys Asp Ser Arg Arg  Glu Met Asp Gly Tyr  Arg Phe Trp 
    1385                 1390                 1395             


Lys Ser  Gly Tyr Trp Ala Ser  His Leu Ala Gly Arg  Lys Tyr His 
    1400                 1405                 1410             


Ile Ser  Ala Leu Tyr Val Val  Asp Leu Lys Lys Phe  Arg Lys Ile 
    1415                 1420                 1425             


Ala Ala  Gly Asp Arg Leu Arg  Gly Gln Tyr Gln Gly  Leu Ser Gln 
    1430                 1435                 1440             


Asp Pro  Asn Ser Leu Ser Asn  Leu Asp Gln Asp Leu  Pro Asn Asn 
    1445                 1450                 1455             


Met Ile  His Gln Val Pro Ile  Lys Ser Leu Pro Gln  Glu Trp Leu 
    1460                 1465                 1470             


Trp Cys  Glu Thr Trp Cys Asp  Asp Ala Ser Lys Lys  Arg Ala Lys 
    1475                 1480                 1485             


Thr Ile  Asp Leu Cys Asn Asn  Pro Met Thr Lys Glu  Pro Lys Leu 
    1490                 1495                 1500             


Glu Ala  Ala Val Arg Ile Val  Pro Glu Trp Gln Asp  Tyr Asp Gln 
    1505                 1510                 1515             


Glu Ile  Lys Gln Leu Gln Ile  Arg Phe Gln Lys Glu  Lys Glu Thr 
    1520                 1525                 1530             


Gly Ala  Leu Tyr Lys Glu Lys  Thr Lys Glu Pro Ser  Arg Glu Gly 
    1535                 1540                 1545             


Pro Gln  Lys Arg Glu Glu Leu  
    1550                 1555 


<210>  80
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
            180                 185                 190         


Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
        195                 200                 205             


Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
    210                 215                 220                 


Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
225                 230                 235                 240 


Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln 
                245                 250                 255     


Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala 
            260                 265                 270         


Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala 
        275                 280                 285             


Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser 
    290                 295                 300                 


Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met 
305                 310                 315                 320 


His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly 
                325                 330                 335     


Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr 
            340                 345                 350         


Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro 
        355                 360                 365             


Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala 
    370                 375                 380                 


Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg 
385                 390                 395                 400 


Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn 
                405                 410                 415     


Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His 
            420                 425                 430         


Ser Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala 
        435                 440                 445             


Val Trp Arg Pro Tyr 
    450             


<210>  81
<211>  1074
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ile Ser Ala Asp Cys Asn Leu Cys Leu Pro Glu Tyr Asp Arg Tyr 
1               5                   10                  15      


Leu Ala Ser Ser Lys Ile Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu 
            20                  25                  30          


Asn His Thr Pro Asn Ser Ser Thr Lys Thr His Leu Gly Thr Gly Met 
        35                  40                  45              


Glu Arg Ser Pro Gly Ala Met Glu Arg Val Leu Lys Val Phe His Tyr 
    50                  55                  60                  


Phe Glu Ser Asn Ser Glu Pro Thr Thr Trp Ala Ser Ile Ile Arg His 
65                  70                  75                  80  


Gly Asp Ala Thr Asp Val Arg Gly Ile Ile Gln Lys Ile Val Asp Ser 
                85                  90                  95      


His Lys Val Lys His Val Ala Cys Tyr Gly Phe Arg Leu Ser His Leu 
            100                 105                 110         


Arg Ser Glu Glu Val His Trp Leu His Val Asp Met Gly Val Ser Ser 
        115                 120                 125             


Val Arg Glu Lys Tyr Glu Leu Ala His Pro Pro Glu Glu Trp Lys Tyr 
    130                 135                 140                 


Glu Leu Arg Ile Arg Tyr Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr 
145                 150                 155                 160 


Glu Asp Lys Pro Thr Leu Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp 
                165                 170                 175     


Tyr Met Leu Glu Ile Ala Asp Gln Val Asp Gln Glu Ile Ala Leu Lys 
            180                 185                 190         


Leu Gly Cys Leu Glu Ile Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn 
        195                 200                 205             


Ala Leu Glu Lys Lys Ser Asn Tyr Glu Val Leu Glu Lys Asp Val Gly 
    210                 215                 220                 


Leu Lys Arg Phe Phe Pro Lys Ser Leu Leu Asp Ser Val Lys Ala Lys 
225                 230                 235                 240 


Thr Leu Arg Lys Leu Ile Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu 
                245                 250                 255     


Asn Arg Glu Glu Ser Ile Leu Lys Phe Phe Glu Ile Leu Ser Pro Val 
            260                 265                 270         


Tyr Arg Phe Asp Lys Glu Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp 
        275                 280                 285             


Ile Ile Ser Val Glu Leu Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr 
    290                 295                 300                 


Leu Thr Asp Lys Gly Cys Asn Pro Thr His Leu Ala Asp Phe Thr Gln 
305                 310                 315                 320 


Val Gln Thr Ile Gln Tyr Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly 
                325                 330                 335     


Met Leu Gln Leu Lys Ile Ala Gly Ala Pro Glu Pro Leu Thr Val Thr 
            340                 345                 350         


Ala Pro Ser Leu Thr Ile Ala Glu Asn Met Ala Asp Leu Ile Asp Gly 
        355                 360                 365             


Tyr Cys Arg Leu Val Asn Gly Thr Ser Gln Ser Phe Ile Ile Arg Pro 
    370                 375                 380                 


Gln Lys Glu Gly Glu Arg Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn 
385                 390                 395                 400 


Ser Glu Lys Gln Gly Met Arg Thr His Ala Val Ser Val Ser Glu Thr 
                405                 410                 415     


Asp Asp Tyr Ala Glu Ile Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro 
            420                 425                 430         


Ser Thr Arg Asp Tyr Glu Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg 
        435                 440                 445             


Cys Ile Gly Glu Gly Gln Phe Gly Asp Val His Gln Gly Ile Tyr Met 
    450                 455                 460                 


Ser Pro Glu Asn Pro Ala Leu Ala Val Ala Ile Lys Thr Cys Lys Asn 
465                 470                 475                 480 


Cys Thr Ser Asp Ser Val Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr 
                485                 490                 495     


Met Arg Gln Phe Asp His Pro His Ile Val Lys Leu Ile Gly Val Ile 
            500                 505                 510         


Thr Glu Asn Pro Val Trp Ile Ile Met Glu Leu Cys Thr Leu Gly Glu 
        515                 520                 525             


Leu Arg Ser Phe Leu Gln Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser 
    530                 535                 540                 


Leu Ile Leu Tyr Ala Tyr Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu 
545                 550                 555                 560 


Ser Lys Arg Phe Val His Arg Asp Ile Ala Ala Arg Asn Val Leu Val 
                565                 570                 575     


Ser Ser Asn Asp Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr 
            580                 585                 590         


Met Glu Asp Ser Thr Tyr Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile 
        595                 600                 605             


Lys Trp Met Ala Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala 
    610                 615                 620                 


Ser Asp Val Trp Met Phe Gly Val Cys Met Trp Glu Ile Leu Met His 
625                 630                 635                 640 


Gly Val Lys Pro Phe Gln Gly Val Lys Asn Asn Asp Val Ile Gly Arg 
                645                 650                 655     


Ile Glu Asn Gly Glu Arg Leu Pro Met Pro Pro Asn Cys Pro Pro Thr 
            660                 665                 670         


Leu Tyr Ser Leu Met Thr Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg 
        675                 680                 685             


Pro Arg Phe Thr Glu Leu Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu 
    690                 695                 700                 


Glu Lys Ala Gln Gln Glu Glu Arg Met Arg Met Glu Ser Arg Arg Gln 
705                 710                 715                 720 


Ala Thr Val Ser Trp Asp Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys 
                725                 730                 735     


Pro Ser Arg Pro Gly Tyr Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr 
            740                 745                 750         


Pro Ser Pro Gln His Met Val Gln Thr Asn His Tyr Gln Val Ser Gly 
        755                 760                 765             


Tyr Pro Gly Ser His Gly Ile Thr Ala Met Ala Gly Ser Ile Tyr Pro 
    770                 775                 780                 


Gly Gln Ala Ser Leu Leu Asp Gln Thr Asp Ser Trp Asn His Arg Pro 
785                 790                 795                 800 


Gln Glu Ile Ala Met Trp Gln Pro Asn Val Glu Asp Ser Thr Val Leu 
                805                 810                 815     


Asp Leu Arg Gly Ile Gly Gln Val Leu Pro Thr His Leu Met Glu Glu 
            820                 825                 830         


Arg Leu Ile Arg Gln Gln Gln Glu Met Glu Glu Asp Gln Arg Trp Leu 
        835                 840                 845             


Glu Lys Glu Glu Arg Phe Leu Lys Pro Asp Val Arg Leu Ser Arg Gly 
    850                 855                 860                 


Ser Ile Asp Arg Glu Asp Gly Ser Leu Gln Gly Pro Ile Gly Asn Gln 
865                 870                 875                 880 


His Ile Tyr Gln Pro Val Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys 
                885                 890                 895     


Lys Pro Pro Arg Pro Gly Ala Pro Gly His Leu Gly Ser Leu Ala Ser 
            900                 905                 910         


Leu Ser Ser Pro Ala Asp Ser Tyr Asn Glu Gly Val Lys Leu Gln Pro 
        915                 920                 925             


Gln Glu Ile Ser Pro Pro Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp 
    930                 935                 940                 


Lys Val Tyr Glu Asn Val Thr Gly Leu Val Lys Ala Val Ile Glu Met 
945                 950                 955                 960 


Ser Ser Lys Ile Gln Pro Ala Pro Pro Glu Glu Tyr Val Pro Met Val 
                965                 970                 975     


Lys Glu Val Gly Leu Ala Leu Arg Thr Leu Leu Ala Thr Val Asp Glu 
            980                 985                 990         


Thr Ile Pro Leu Leu Pro Ala Ser  Thr His Arg Glu Ile  Glu Met Ala 
        995                 1000                 1005             


Gln Lys  Leu Leu Asn Ser Asp  Leu Gly Glu Leu Ile  Asn Lys Met 
    1010                 1015                 1020             


Lys Leu  Ala Gln Gln Tyr Val  Met Thr Ser Leu Gln  Gln Glu Tyr 
    1025                 1030                 1035             


Lys Lys  Gln Met Leu Thr Ala  Ala His Ala Leu Ala  Val Asp Ala 
    1040                 1045                 1050             


Lys Asn  Leu Leu Asp Val Ile  Asp Gln Ala Arg Leu  Lys Met Leu 
    1055                 1060                 1065             


Gly Gln  Thr Arg Pro His 
    1070                 


<210>  82
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Gly Glu Ser Ser Glu Asp Ile Asp Gln Met Phe Ser Thr Leu Leu 
1               5                   10                  15      


Gly Glu Met Asp Leu Leu Thr Gln Ser Leu Gly Val Asp Thr Leu Pro 
            20                  25                  30          


Pro Pro Asp Pro Asn Pro Pro Arg Ala Glu Phe Asn Tyr Ser Val Gly 
        35                  40                  45              


Phe Lys Asp Leu Asn Glu Ser Leu Asn Ala Leu Glu Asp Gln Asp Leu 
    50                  55                  60                  


Asp Ala Leu Met Ala Asp Leu Val Ala Asp Ile Ser Glu Ala Glu Gln 
65                  70                  75                  80  


Arg Thr Ile Gln Ala Gln Lys Glu Ser Leu Gln Asn Gln His His Ser 
                85                  90                  95      


Ala Ser Leu Gln Ala Ser Ile Phe Ser Gly Ala Ala Ser Leu Gly Tyr 
            100                 105                 110         


Gly Thr Asn Val Ala Ala Thr Gly Ile Ser Gln Tyr Glu Asp Asp Leu 
        115                 120                 125             


Pro Pro Pro Pro Ala Asp Pro Val Leu Asp Leu Pro Leu Pro Pro Pro 
    130                 135                 140                 


Pro Pro Glu Pro Leu Ser Gln Glu Glu Glu Glu Ala Gln Ala Lys Ala 
145                 150                 155                 160 


Asp Lys Ile Lys Leu Ala Leu Glu Lys Leu Lys Glu Ala Lys Val Lys 
                165                 170                 175     


Lys Leu Val Val Lys Val His Met Asn Asp Asn Ser Thr Lys Ser Leu 
            180                 185                 190         


Met Val Asp Glu Arg Gln Leu Ala Arg Asp Val Leu Asp Asn Leu Phe 
        195                 200                 205             


Glu Lys Thr His Cys Asp Cys Asn Val Asp Trp Cys Leu Tyr Glu Ile 
    210                 215                 220                 


Tyr Pro Glu Leu Gln Ile Glu Arg Phe Phe Glu Asp His Glu Asn Val 
225                 230                 235                 240 


Val Glu Val Leu Ser Asp Trp Thr Arg Asp Thr Glu Asn Lys Ile Leu 
                245                 250                 255     


Phe Leu Glu Lys Glu Glu Lys Tyr Ala Val Phe Lys Asn Pro Gln Asn 
            260                 265                 270         


Phe Tyr Leu Asp Asn Arg Gly Lys Lys Glu Ser Lys Glu Thr Asn Glu 
        275                 280                 285             


Lys Met Asn Ala Lys Asn Lys Glu Ser Leu Leu Glu Glu Ser Phe Cys 
    290                 295                 300                 


Gly Thr Ser Ile Ile Val Pro Glu Leu Glu Gly Ala Leu Tyr Leu Lys 
305                 310                 315                 320 


Glu Asp Gly Lys Lys Ser Trp Lys Arg Arg Tyr Phe Leu Leu Arg Ala 
                325                 330                 335     


Ser Gly Ile Tyr Tyr Val Pro Lys Gly Lys Thr Lys Thr Ser Arg Asp 
            340                 345                 350         


Leu Ala Cys Phe Ile Gln Phe Glu Asn Val Asn Ile Tyr Tyr Gly Thr 
        355                 360                 365             


Gln His Lys Met Lys Tyr Lys Ala Pro Thr Asp Tyr Cys Phe Val Leu 
    370                 375                 380                 


Lys His Pro Gln Ile Gln Lys Glu Ser Gln Tyr Ile Lys Tyr Leu Cys 
385                 390                 395                 400 


Cys Asp Asp Thr Arg Thr Leu Asn Gln Trp Val Met Gly Ile Arg Ile 
                405                 410                 415     


Ala Lys Tyr Gly Lys Thr Leu Tyr Asp Asn Tyr Gln Arg Ala Val Ala 
            420                 425                 430         


Lys Ala Gly Leu Ala Ser Arg Trp Thr Asn Leu Gly Thr Val Asn Ala 
        435                 440                 445             


Ala Ala Pro Ala Gln Pro Ser Thr Gly Pro Lys Thr Gly Thr Thr Gln 
    450                 455                 460                 


Pro Asn Gly Gln Ile Pro Gln Ala Thr His Ser Val Ser Ala Val Leu 
465                 470                 475                 480 


Gln Glu Ala Gln Arg His Ala Glu Thr Ser Lys Asp Lys Lys Pro Ala 
                485                 490                 495     


Leu Gly Asn His His Asp Pro Ala Val Pro Arg Ala Pro His Ala Pro 
            500                 505                 510         


Lys Ser Ser Leu Pro Pro Pro Pro Pro Val Arg Arg Ser Ser Asp Thr 
        515                 520                 525             


Ser Gly Ser Pro Ala Thr Pro Leu Lys Ala Lys Gly Thr Gly Gly Gly 
    530                 535                 540                 


Gly Leu Pro Ala Pro Pro Asp Asp Phe Leu Pro Pro Pro Pro Pro Pro 
545                 550                 555                 560 


Pro Pro Leu Asp Asp Pro Glu Leu Pro Pro Pro Pro Pro Asp Phe Met 
                565                 570                 575     


Glu Pro Pro Pro Asp Phe Val Pro Pro Pro Pro Pro Ser Tyr Ala Gly 
            580                 585                 590         


Ile Ala Gly Ser Glu Leu Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro 
        595                 600                 605             


Ala Pro Ala Pro Val Pro Asp Ser Ala Arg Pro Pro Pro Ala Val Ala 
    610                 615                 620                 


Lys Arg Pro Pro Val Pro Pro Lys Arg Gln Glu Asn Pro Gly His Pro 
625                 630                 635                 640 


Gly Gly Ala Gly Gly Gly Glu Gln Asp Phe Met Ser Asp Leu Met Lys 
                645                 650                 655     


Ala Leu Gln Lys Lys Arg Gly Asn Val Ser 
            660                 665     


<210>  83
<211>  1234
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ala Gly Ala Gln Pro Gly Val His Ala Leu Gln Leu Glu Pro Pro 
1               5                   10                  15      


Thr Val Val Glu Thr Leu Arg Arg Gly Ser Lys Phe Ile Lys Trp Asp 
            20                  25                  30          


Glu Glu Thr Ser Ser Arg Asn Leu Val Thr Leu Arg Val Asp Pro Asn 
        35                  40                  45              


Gly Phe Phe Leu Tyr Trp Thr Gly Pro Asn Met Glu Val Asp Thr Leu 
    50                  55                  60                  


Asp Ile Ser Ser Ile Arg Asp Thr Arg Thr Gly Arg Tyr Ala Arg Leu 
65                  70                  75                  80  


Pro Lys Asp Pro Lys Ile Arg Glu Val Leu Gly Phe Gly Gly Pro Asp 
                85                  90                  95      


Ala Arg Leu Glu Glu Lys Leu Met Thr Val Val Ser Gly Pro Asp Pro 
            100                 105                 110         


Val Asn Thr Val Phe Leu Asn Phe Met Ala Val Gln Asp Asp Thr Ala 
        115                 120                 125             


Lys Val Trp Ser Glu Glu Leu Phe Lys Leu Ala Met Asn Ile Leu Ala 
    130                 135                 140                 


Gln Asn Ala Ser Arg Asn Thr Phe Leu Arg Lys Ala Tyr Thr Lys Leu 
145                 150                 155                 160 


Lys Leu Gln Val Asn Gln Asp Gly Arg Ile Pro Val Lys Asn Ile Leu 
                165                 170                 175     


Lys Met Phe Ser Ala Asp Lys Lys Arg Val Glu Thr Ala Leu Glu Ser 
            180                 185                 190         


Cys Gly Leu Lys Phe Asn Arg Ser Glu Ser Ile Arg Pro Asp Glu Phe 
        195                 200                 205             


Ser Leu Glu Ile Phe Glu Arg Phe Leu Asn Lys Leu Cys Leu Arg Pro 
    210                 215                 220                 


Asp Ile Asp Lys Ile Leu Leu Glu Ile Gly Ala Lys Gly Lys Pro Tyr 
225                 230                 235                 240 


Leu Thr Leu Glu Gln Leu Met Asp Phe Ile Asn Gln Lys Gln Arg Asp 
                245                 250                 255     


Pro Arg Leu Asn Glu Val Leu Tyr Pro Pro Leu Arg Pro Ser Gln Ala 
            260                 265                 270         


Arg Leu Leu Ile Glu Lys Tyr Glu Pro Asn Gln Gln Phe Leu Glu Arg 
        275                 280                 285             


Asp Gln Met Ser Met Glu Gly Phe Ser Arg Tyr Leu Gly Gly Glu Glu 
    290                 295                 300                 


Asn Gly Ile Leu Pro Leu Glu Ala Leu Asp Leu Ser Thr Asp Met Thr 
305                 310                 315                 320 


Gln Pro Leu Ser Ala Tyr Phe Ile Asn Ser Ser His Asn Thr Tyr Leu 
                325                 330                 335     


Thr Ala Gly Gln Leu Ala Gly Thr Ser Ser Val Glu Met Tyr Arg Gln 
            340                 345                 350         


Ala Leu Leu Trp Gly Cys Arg Cys Val Glu Leu Asp Val Trp Lys Gly 
        355                 360                 365             


Arg Pro Pro Glu Glu Glu Pro Phe Ile Thr His Gly Phe Thr Met Thr 
    370                 375                 380                 


Thr Glu Val Pro Leu Arg Asp Val Leu Glu Ala Ile Ala Glu Thr Ala 
385                 390                 395                 400 


Phe Lys Thr Ser Pro Tyr Pro Val Ile Leu Ser Phe Glu Asn His Val 
                405                 410                 415     


Asp Ser Ala Lys Gln Gln Ala Lys Met Ala Glu Tyr Cys Arg Ser Ile 
            420                 425                 430         


Phe Gly Asp Ala Leu Leu Ile Glu Pro Leu Asp Lys Tyr Pro Leu Ala 
        435                 440                 445             


Pro Gly Val Pro Leu Pro Ser Pro Gln Asp Leu Met Gly Arg Ile Leu 
    450                 455                 460                 


Val Lys Asn Lys Lys Arg His Arg Pro Ser Ala Gly Gly Pro Asp Ser 
465                 470                 475                 480 


Ala Gly Arg Lys Arg Pro Leu Glu Gln Ser Asn Ser Ala Leu Ser Glu 
                485                 490                 495     


Ser Ser Ala Ala Thr Glu Pro Ser Ser Pro Gln Leu Gly Ser Pro Ser 
            500                 505                 510         


Ser Asp Ser Cys Pro Gly Leu Ser Asn Gly Glu Glu Val Gly Leu Glu 
        515                 520                 525             


Lys Pro Ser Leu Glu Pro Gln Lys Ser Leu Gly Asp Glu Gly Leu Asn 
    530                 535                 540                 


Arg Gly Pro Tyr Val Leu Gly Pro Ala Asp Arg Glu Asp Glu Glu Glu 
545                 550                 555                 560 


Asp Glu Glu Glu Glu Glu Gln Thr Asp Pro Lys Lys Pro Thr Thr Asp 
                565                 570                 575     


Glu Gly Thr Ala Ser Ser Glu Val Asn Ala Thr Glu Glu Met Ser Thr 
            580                 585                 590         


Leu Val Asn Tyr Ile Glu Pro Val Lys Phe Lys Ser Phe Glu Ala Ala 
        595                 600                 605             


Arg Lys Arg Asn Lys Cys Phe Glu Met Ser Ser Phe Val Glu Thr Lys 
    610                 615                 620                 


Ala Met Glu Gln Leu Thr Lys Ser Pro Met Glu Phe Val Glu Tyr Asn 
625                 630                 635                 640 


Lys Gln Gln Leu Ser Arg Ile Tyr Pro Lys Gly Thr Arg Val Asp Ser 
                645                 650                 655     


Ser Asn Tyr Met Pro Gln Leu Phe Trp Asn Val Gly Cys Gln Leu Val 
            660                 665                 670         


Ala Leu Asn Phe Gln Thr Leu Asp Val Ala Met Gln Leu Asn Ala Gly 
        675                 680                 685             


Val Phe Glu Tyr Asn Gly Arg Ser Gly Tyr Leu Leu Lys Pro Glu Phe 
    690                 695                 700                 


Met Arg Arg Pro Asp Lys Ser Phe Asp Pro Phe Thr Glu Val Ile Val 
705                 710                 715                 720 


Asp Gly Ile Val Ala Asn Ala Leu Arg Val Lys Val Ile Ser Gly Gln 
                725                 730                 735     


Phe Leu Ser Asp Arg Lys Val Gly Ile Tyr Val Glu Val Asp Met Phe 
            740                 745                 750         


Gly Leu Pro Val Asp Thr Arg Arg Lys Tyr Arg Thr Arg Thr Ser Gln 
        755                 760                 765             


Gly Asn Ser Phe Asn Pro Val Trp Asp Glu Glu Pro Phe Asp Phe Pro 
    770                 775                 780                 


Lys Val Val Leu Pro Thr Leu Ala Ser Leu Arg Ile Ala Ala Phe Glu 
785                 790                 795                 800 


Glu Gly Gly Lys Phe Val Gly His Arg Ile Leu Pro Val Ser Ala Ile 
                805                 810                 815     


Arg Ser Gly Tyr His Tyr Val Cys Leu Arg Asn Glu Ala Asn Gln Pro 
            820                 825                 830         


Leu Cys Leu Pro Ala Leu Leu Ile Tyr Thr Glu Ala Ser Asp Tyr Ile 
        835                 840                 845             


Pro Asp Asp His Gln Asp Tyr Ala Glu Ala Leu Ile Asn Pro Ile Lys 
    850                 855                 860                 


His Val Ser Leu Met Asp Gln Arg Ala Arg Gln Leu Ala Ala Leu Ile 
865                 870                 875                 880 


Gly Glu Ser Glu Ala Gln Ala Gly Gln Glu Thr Cys Gln Asp Thr Gln 
                885                 890                 895     


Ser Gln Gln Leu Gly Ser Gln Pro Ser Ser Asn Pro Thr Pro Ser Pro 
            900                 905                 910         


Leu Asp Ala Ser Pro Arg Arg Pro Pro Gly Pro Thr Thr Ser Pro Ala 
        915                 920                 925             


Ser Thr Ser Leu Ser Ser Pro Gly Gln Arg Asp Asp Leu Ile Ala Ser 
    930                 935                 940                 


Ile Leu Ser Glu Val Ala Pro Thr Pro Leu Asp Glu Leu Arg Gly His 
945                 950                 955                 960 


Lys Ala Leu Val Lys Leu Arg Ser Arg Gln Glu Arg Asp Leu Arg Glu 
                965                 970                 975     


Leu Arg Lys Lys His Gln Arg Lys Ala Val Thr Leu Thr Arg Arg Leu 
            980                 985                 990         


Leu Asp Gly Leu Ala Gln Ala Gln  Ala Glu Gly Arg Cys  Arg Leu Arg 
        995                 1000                 1005             


Pro Gly  Ala Leu Gly Gly Ala  Ala Asp Val Glu Asp  Thr Lys Glu 
    1010                 1015                 1020             


Gly Glu  Asp Glu Ala Lys Arg  Tyr Gln Glu Phe Gln  Asn Arg Gln 
    1025                 1030                 1035             


Val Gln  Ser Leu Leu Glu Leu  Arg Glu Ala Gln Val  Asp Ala Glu 
    1040                 1045                 1050             


Ala Gln  Arg Arg Leu Glu His  Leu Arg Gln Ala Leu  Gln Arg Leu 
    1055                 1060                 1065             


Arg Glu  Val Val Leu Asp Ala  Asn Thr Thr Gln Phe  Lys Arg Leu 
    1070                 1075                 1080             


Lys Glu  Met Asn Glu Arg Glu  Lys Lys Glu Leu Gln  Lys Ile Leu 
    1085                 1090                 1095             


Asp Arg  Lys Arg His Asn Ser  Ile Ser Glu Ala Lys  Met Arg Asp 
    1100                 1105                 1110             


Lys His  Lys Lys Glu Ala Glu  Leu Thr Glu Ile Asn  Arg Arg His 
    1115                 1120                 1125             


Ile Thr  Glu Ser Val Asn Ser  Ile Arg Arg Leu Glu  Glu Ala Gln 
    1130                 1135                 1140             


Lys Gln  Arg His Asp Arg Leu  Val Ala Gly Gln Gln  Gln Val Leu 
    1145                 1150                 1155             


Gln Gln  Leu Ala Glu Glu Glu  Pro Lys Leu Leu Ala  Gln Leu Ala 
    1160                 1165                 1170             


Gln Glu  Cys Gln Glu Gln Arg  Ala Arg Leu Pro Gln  Glu Ile Arg 
    1175                 1180                 1185             


Arg Ser  Leu Leu Gly Glu Met  Pro Glu Gly Leu Gly  Asp Gly Pro 
    1190                 1195                 1200             


Leu Val  Ala Cys Ala Ser Asn  Gly His Ala Pro Gly  Ser Ser Gly 
    1205                 1210                 1215             


His Leu  Ser Gly Ala Asp Ser  Glu Ser Gln Glu Glu  Asn Thr Gln 
    1220                 1225                 1230             


Leu 
    


<210>  84
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val 
            20                  25                  30          


Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser 
        35                  40                  45              


Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp 
    50                  55                  60                  


Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser 
65                  70                  75                  80  


Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val 
                85                  90                  95      


Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu 
            100                 105                 110         


Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His 
        115                 120                 125             


Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val 
    130                 135                 140                 


Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val 
                165                 170                 175     


His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr 
            180                 185                 190         


Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu 
        195                 200                 205             


Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser 
    210                 215                 220                 


Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala 
225                 230                 235                 240 


Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val 
                245                 250                 255     


Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala 
            260                 265                 270         


Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu 
        275                 280                 285             


Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln 
    290                 295                 300                 


Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu 
305                 310                 315                 320 


Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly 
                325                 330                 335     


Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala 
            340                 345                 350         


Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly 
        355                 360                 365             


Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val 
    370                 375                 380                 


Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp 
385                 390                 395                 400 


Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly 
                405                 410                 415     


Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val 
            420                 425                 430         


His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala 
        435                 440                 445             


Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile 
    450                 455                 460                 


Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp 
465                 470                 475                 480 


Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu 
                485                 490                 495     


Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro 
            500                 505                 510         


Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg 
        515                 520                 525             


Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys 
    530                 535                 540                 


Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala 
545                 550                 555                 560 


Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala 
                565                 570                 575     


Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu 
            580                 585                 590         


Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys 
        595                 600                 605             


Arg Leu Arg Lys Arg 
    610             


<210>  85
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ser Ser Ser Gly Gly Ala Pro Gly Ala Ser Ala Ser Ser Ala Pro 
1               5                   10                  15      


Pro Ala Gln Glu Glu Gly Met Thr Trp Trp Tyr Arg Trp Leu Cys Arg 
            20                  25                  30          


Leu Ser Gly Val Leu Gly Ala Val Ser Cys Ala Ile Ser Gly Leu Phe 
        35                  40                  45              


Asn Cys Ile Thr Ile His Pro Leu Asn Ile Ala Ala Gly Val Trp Met 
    50                  55                  60                  


Met Met Ala Val Val Pro Ile Val Ile Ser Leu Thr Leu Thr Thr Leu 
65                  70                  75                  80  


Leu Gly Asn Ala Ile Ala Phe Ala Thr Gly Val Leu Tyr Gly Leu Ser 
                85                  90                  95      


Ala Leu Gly Lys Lys Gly Asp Ala Ile Ser Tyr Ala Arg Ile Gln Gln 
            100                 105                 110         


Gln Arg Gln Gln Ala Asp Glu Glu Lys Leu Ala Glu Thr Leu Glu Gly 
        115                 120                 125             


Glu Leu 
    130 


<210>  86
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Asp Ala Leu Val Glu Asp Asp Ile Cys Ile Leu Asn His Glu Lys 
1               5                   10                  15      


Ala His Lys Arg Asp Thr Val Thr Pro Val Ser Ile Tyr Ser Gly Asp 
            20                  25                  30          


Glu Ser Val Ala Ser His Phe Ala Leu Val Thr Ala Tyr Glu Asp Ile 
        35                  40                  45              


Lys Lys Arg Leu Lys Asp Ser Glu Lys Glu Asn Ser Leu Leu Lys Lys 
    50                  55                  60                  


Arg Ile Arg Phe Leu Glu Glu Lys Leu Ile Ala Arg Phe Glu Glu Glu 
65                  70                  75                  80  


Thr Ser Ser Val Gly Arg Glu Gln Val Asn Lys Ala Tyr His Ala Tyr 
                85                  90                  95      


Arg Glu Val Cys Ile Asp Arg Asp Asn Leu Lys Ser Lys Leu Asp Lys 
            100                 105                 110         


Met Asn Lys Asp Asn Ser Glu Ser Leu Lys Val Leu Asn Glu Gln Leu 
        115                 120                 125             


Gln Ser Lys Glu Val Glu Leu Leu Gln Leu Arg Thr Glu Val Glu Thr 
    130                 135                 140                 


Gln Gln Val Met Arg Asn Leu Asn Pro Pro Ser Ser Asn Trp Glu Val 
145                 150                 155                 160 


Glu Lys Leu Ser Cys Asp Leu Lys Ile His Gly Leu Glu Gln Glu Leu 
                165                 170                 175     


Glu Leu Met Arg Lys Glu Cys Ser Asp Leu Lys Ile Glu Leu Gln Lys 
            180                 185                 190         


Ala Lys Gln Thr Asp Pro Tyr Gln Glu Asp Asn Leu Lys Ser Arg Asp 
        195                 200                 205             


Leu Gln Lys Leu Ser Ile Ser Ser Asp Asn Met Gln His Ala Tyr Trp 
    210                 215                 220                 


Glu Leu Lys Arg Glu Met Ser Asn Leu His Leu Val Thr Gln Val Gln 
225                 230                 235                 240 


Ala Glu Leu Leu Arg Lys Leu Lys Thr Ser Thr Ala Ile Lys Lys Ala 
                245                 250                 255     


Cys Ala Pro Val Gly Cys Ser Glu Asp Leu Gly Arg Asp Ser Thr Lys 
            260                 265                 270         


Leu His Leu Met Asn Phe Thr Ala Thr Tyr Thr Arg His Pro Pro Leu 
        275                 280                 285             


Leu Pro Asn Gly Lys Ala Leu Cys His Thr Thr Ser Ser Pro Leu Pro 
    290                 295                 300                 


Gly Asp Val Lys Val Leu Ser Glu Lys Ala Ile Leu Gln Ser Trp Thr 
305                 310                 315                 320 


Asp Asn Glu Arg Ser Ile Pro Asn Asp Gly Thr Cys Phe Gln Glu His 
                325                 330                 335     


Ser Ser Tyr Gly Arg Asn Ser Leu Glu Asp Asn Ser Trp Val Phe Pro 
            340                 345                 350         


Ser Pro Pro Lys Ser Ser Glu Thr Ala Phe Gly Glu Thr Lys Thr Lys 
        355                 360                 365             


Thr Leu Pro Leu Pro Asn Leu Pro Pro Leu His Tyr Leu Asp Gln His 
    370                 375                 380                 


Asn Gln Asn Cys Leu Tyr Lys Asn 
385                 390         


<210>  87
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ala Ser Ser Thr Ser Leu Pro Ala Pro Gly Ser Arg Pro Lys Lys 
1               5                   10                  15      


Pro Leu Gly Lys Met Ala Asp Trp Phe Arg Gln Thr Leu Leu Lys Lys 
            20                  25                  30          


Pro Lys Lys Arg Pro Asn Ser Pro Glu Ser Thr Ser Ser Asp Ala Ser 
        35                  40                  45              


Gln Pro Thr Ser Gln Asp Ser Pro Leu Pro Pro Ser Leu Ser Ser Val 
    50                  55                  60                  


Thr Ser Pro Ser Leu Pro Pro Thr His Ala Ser Asp Ser Gly Ser Ser 
65                  70                  75                  80  


Arg Trp Ser Lys Asp Tyr Asp Val Cys Val Cys His Ser Glu Glu Asp 
                85                  90                  95      


Leu Val Ala Ala Gln Asp Leu Val Ser Tyr Leu Glu Gly Ser Thr Ala 
            100                 105                 110         


Ser Leu Arg Cys Phe Leu Gln Leu Arg Asp Ala Thr Pro Gly Gly Ala 
        115                 120                 125             


Ile Val Ser Glu Leu Cys Gln Ala Leu Ser Ser Ser His Cys Arg Val 
    130                 135                 140                 


Leu Leu Ile Thr Pro Gly Phe Leu Gln Asp Pro Trp Cys Lys Tyr Gln 
145                 150                 155                 160 


Met Leu Gln Ala Leu Thr Glu Ala Pro Gly Ala Glu Gly Cys Thr Ile 
                165                 170                 175     


Pro Leu Leu Ser Gly Leu Ser Arg Ala Ala Tyr Pro Pro Glu Leu Arg 
            180                 185                 190         


Phe Met Tyr Tyr Val Asp Gly Arg Gly Pro Asp Gly Gly Phe Arg Gln 
        195                 200                 205             


Val Lys Glu Ala Val Met Arg Tyr Leu Gln Thr Leu Ser 
    210                 215                 220     


<210>  88
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu 
1               5                   10                  15      


Gly Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu 
            20                  25                  30          


Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val 
        35                  40                  45              


Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp 
    50                  55                  60                  


Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser 
65                  70                  75                  80  


Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met 
                85                  90                  95      


Ile Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val 
            100                 105                 110         


Tyr Phe Ser Thr 
        115     


<210>  89
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 


<210>  90
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Pro Pro Ser Leu Thr Glu Leu His 
65                  70                  75                  80  


Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser Leu Lys Gly 
                85                  90                  95      


Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala 
            100                 105                 110         


Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg Glu Leu His 
        115                 120                 125             


Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu Ala Glu His 
    130                 135                 140                 


Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile Ser Val Val 
145                 150                 155                 160 


Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys Lys Ala Ser 
                165                 170                 175     


Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr Trp Glu Ile 
            180                 185                 190         


Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala Ile Gln Leu 
        195                 200                 205             


Gly Asn Tyr Lys 
    210         


<210>  91
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn 
1               5                   10                  15      


Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg 
            20                  25                  30          


Asp Gly Arg Ser Ser Gly Asp Thr Ser Ser Glu Val Ser Thr Val Glu 
        35                  40                  45              


Leu Leu His Leu Gln Gln Gln Gln Ala Leu Gln Ala Ala Arg Gln Leu 
    50                  55                  60                  


Leu Leu Gln Gln Gln Thr Ser Gly Leu Lys Ser Pro Lys Ser Ser Asp 
65                  70                  75                  80  


Lys Gln Arg Pro Leu Gln Val Pro Val Ser Val Ala Met Met Thr Pro 
                85                  90                  95      


Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu Gln Gln Gln Val 
            100                 105                 110         


Leu Ser Pro Gln Gln Leu Gln Ala Leu Leu Gln Gln Gln Gln Ala Val 
        115                 120                 125             


Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys Lys Gln Gln Glu 
    130                 135                 140                 


Gln Leu His Leu Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
145                 150                 155                 160 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His 
            180                 185                 190         


Pro Gly Lys Gln Ala Lys Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        195                 200                 205             


Leu Ala Ala Gln Gln Leu Val Phe Gln Gln Gln Leu Leu Gln Met Gln 
    210                 215                 220                 


Gln Leu Gln Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu 
225                 230                 235                 240 


Ile Ser Ile Pro Pro Gly Gln Ala Ala Leu Pro Val Gln Ser Leu Pro 
                245                 250                 255     


Gln Ala Gly Leu Ser Pro Ala Glu Ile Gln Gln Leu Trp Lys Glu Val 
            260                 265                 270         


Thr Gly Val His Ser Met Glu Asp Asn Gly Ile Lys His Gly Gly Leu 
        275                 280                 285             


Asp Leu Thr Thr Asn Asn Ser Ser Ser Thr Thr Ser Ser Asn Thr Ser 
    290                 295                 300                 


Lys Ala Ser Pro Pro Ile Thr His His Ser Ile Val Asn Gly Gln Ser 
305                 310                 315                 320 


Ser Val Leu Ser Ala Arg Arg Asp Ser Ser Ser His Glu Glu Thr Gly 
                325                 330                 335     


Ala Ser His Thr Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys 
            340                 345                 350         


Glu Ser Ile Cys Glu Asp Phe Gly Gln Phe Leu Lys His Leu Asn Asn 
        355                 360                 365             


Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met 
    370                 375                 380                 


Gln Val Val Gln Gln Leu Glu Ile Gln Leu Ser Lys Glu Arg Glu Arg 
385                 390                 395                 400 


Leu Gln Ala Met Met Thr His Leu His Met Arg Pro Ser Glu Pro Lys 
                405                 410                 415     


Pro Ser Pro Lys Pro Leu Asn Leu Val Ser Ser Val Thr Met Ser Lys 
            420                 425                 430         


Asn Met Leu Glu Thr Ser Pro Gln Ser Leu Pro Gln Thr Pro Thr Thr 
        435                 440                 445             


Pro Thr Ala Pro Val Thr Pro Ile Thr Gln Gly Pro Ser Val Ile Thr 
    450                 455                 460                 


Pro Ala Ser Val Pro Asn Val Gly Ala Ile Arg Arg Arg His Ser Asp 
465                 470                 475                 480 


Lys Tyr Asn Ile Pro Met Ser Ser Glu Ile Ala Pro Asn Tyr Glu Phe 
                485                 490                 495     


Tyr Lys Asn Ala Asp Val Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile 
            500                 505                 510         


Arg Gln Ala Ile Met Glu Ser Ser Asp Arg Gln Leu Thr Leu Asn Glu 
        515                 520                 525             


Ile Tyr Ser Trp Phe Thr Arg Thr Phe Ala Tyr Phe Arg Arg Asn Ala 
    530                 535                 540                 


Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys 
545                 550                 555                 560 


Phe Val Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu 
                565                 570                 575     


Val Glu Tyr Gln Lys Arg Arg Ser Gln Lys Ile Thr Gly Ser Pro Thr 
            580                 585                 590         


Leu Val Lys Asn Ile Pro Thr Ser Leu Gly Tyr Gly Ala Ala Leu Asn 
        595                 600                 605             


Ala Ser Leu Gln Ala Ala Leu Ala Glu Ser Ser Leu Pro Leu Leu Ser 
    610                 615                 620                 


Asn Pro Gly Leu Ile Asn Asn Ala Ser Ser Gly Leu Leu Gln Ala Val 
625                 630                 635                 640 


His Glu Asp Leu Asn Gly Ser Leu Asp His Ile Asp Ser Asn Gly Asn 
                645                 650                 655     


Ser Ser Pro Gly Cys Ser Pro Gln Pro His Ile His Ser Ile His Val 
            660                 665                 670         


Lys Glu Glu Pro Val Ile Ala Glu Asp Glu Asp Cys Pro Met Ser Leu 
        675                 680                 685             


Val Thr Thr Ala Asn His Ser Pro Glu Leu Glu Asp Asp Arg Glu Ile 
    690                 695                 700                 


Glu Glu Glu Pro Leu Ser Glu Asp Leu Glu 
705                 710                 


<210>  92
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210>  93
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Arg Pro Lys Thr Gly Gln Val Gly Cys Glu Thr Pro Glu Glu Leu 
1               5                   10                  15      


Gly Pro Gly Pro Arg Gln Arg Trp Pro Leu Leu Leu Leu Gly Leu Ala 
            20                  25                  30          


Met Val Ala His Gly Leu Leu Arg Pro Met Val Ala Pro Gln Ser Gly 
        35                  40                  45              


Asp Pro Asp Pro Gly Ala Ser Val Gly Ser Ser Arg Ser Ser Leu Arg 
    50                  55                  60                  


Ser Leu Trp Gly Arg Leu Leu Leu Gln Pro Ser Pro Gln Arg Ala Asp 
65                  70                  75                  80  


Pro Arg Cys Trp Pro Arg Gly Phe Trp Ser Glu Pro Gln Ser Leu Cys 
                85                  90                  95      


Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  94
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Val Ala Arg Val Gly Leu Leu Leu Arg Ala Leu Gln Leu Leu Leu 
1               5                   10                  15      


Trp Gly His Leu Asp Ala Gln Pro Ala Glu Arg Gly Gly Gln Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Glu Ala Phe Leu Glu Lys Tyr Gly Tyr Leu Asn Glu 
        35                  40                  45              


Gln Val Pro Lys Ala Pro Thr Ser Thr Arg Phe Ser Asp Ala Ile Arg 
    50                  55                  60                  


Ala Phe Gln Trp Val Ser Gln Leu Pro Val Ser Gly Val Leu Asp Arg 
65                  70                  75                  80  


Ala Thr Leu Arg Gln Met Thr Arg Pro Arg Cys Gly Val Thr Asp Thr 
                85                  90                  95      


Asn Ser Tyr Ala Ala Trp Ala Glu Arg Ile Ser Asp Leu Phe Ala Arg 
            100                 105                 110         


His Arg Thr Lys Met Arg Arg Lys Lys Arg Phe Ala Lys Gln Gly Asn 
        115                 120                 125             


Lys Trp Tyr Lys Gln His Leu Ser Tyr Arg Leu Val Asn Trp Pro Glu 
    130                 135                 140                 


His Leu Pro Glu Pro Ala Val Arg Gly Ala Val Arg Ala Ala Phe Gln 
145                 150                 155                 160 


Leu Trp Ser Asn Val Ser Ala Leu Glu Phe Trp Glu Ala Pro Ala Thr 
                165                 170                 175     


Gly Pro Ala Asp Ile Arg Leu Thr Phe Phe Gln Gly Asp His Asn Asp 
            180                 185                 190         


Gly Leu Gly Asn Ala Phe Asp Gly Pro Gly Gly Ala Leu Ala His Ala 
        195                 200                 205             


Phe Leu Pro Arg Arg Gly Glu Ala His Phe Asp Gln Asp Glu Arg Trp 
    210                 215                 220                 


Ser Leu Ser Arg Arg Arg Gly Arg Asn Leu Phe Val Val Leu Ala His 
225                 230                 235                 240 


Glu Ile Gly His Thr Leu Gly Leu Thr His Ser Pro Ala Pro Arg Ala 
                245                 250                 255     


Leu Met Ala Pro Tyr Tyr Lys Arg Leu Gly Arg Asp Ala Leu Leu Ser 
            260                 265                 270         


Trp Asp Asp Val Leu Ala Val Gln Ser Leu Tyr Gly Lys Pro Leu Gly 
        275                 280                 285             


Gly Ser Val Ala Val Gln Leu Pro Gly Lys Leu Phe Thr Asp Phe Glu 
    290                 295                 300                 


Thr Trp Asp Ser Tyr Ser Pro Gln Gly Arg Arg Pro Glu Thr Gln Gly 
305                 310                 315                 320 


Pro Lys Tyr Cys His Ser Ser Phe Asp Ala Ile Thr Val Asp Arg Gln 
                325                 330                 335     


Gln Gln Leu Tyr Ile Phe Lys Gly Ser His Phe Trp Glu Val Ala Ala 
            340                 345                 350         


Asp Gly Asn Val Ser Glu Pro Arg Pro Leu Gln Glu Arg Trp Val Gly 
        355                 360                 365             


Leu Pro Pro Asn Ile Glu Ala Ala Ala Val Ser Leu Asn Asp Gly Asp 
    370                 375                 380                 


Phe Tyr Phe Phe Lys Gly Gly Arg Cys Trp Arg Phe Arg Gly Pro Lys 
385                 390                 395                 400 


Pro Val Trp Gly Leu Pro Gln Leu Cys Arg Ala Gly Gly Leu Pro Arg 
                405                 410                 415     


His Pro Asp Ala Ala Leu Phe Phe Pro Pro Leu Arg Arg Leu Ile Leu 
            420                 425                 430         


Phe Lys Gly Ala Arg Tyr Tyr Val Leu Ala Arg Gly Gly Leu Gln Val 
        435                 440                 445             


Glu Pro Tyr Tyr Pro Arg Ser Leu Gln Asp Trp Gly Gly Ile Pro Glu 
    450                 455                 460                 


Glu Val Ser Gly Ala Leu Pro Arg Pro Asp Gly Ser Ile Ile Phe Phe 
465                 470                 475                 480 


Arg Asp Asp Arg Tyr Trp Arg Leu Asp Gln Ala Lys Leu Gln Ala Thr 
                485                 490                 495     


Thr Ser Gly Arg Trp Ala Thr Glu Leu Pro Trp Met Gly Cys Trp His 
            500                 505                 510         


Ala Asn Ser Gly Ser Ala Leu Phe 
        515                 520 


<210>  95
<211>  1156
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Val Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Glu  Asn Ser His Glu Ser  Ala Asp Phe Ser Ala  Ala Glu Leu 
    1115                 1120                 1125             


Ile Ser  Val Ser Lys Phe Leu  Pro Ile Ser Gly Met  Glu Lys Glu 
    1130                 1135                 1140             


Ala Ile  Leu Ser His Thr Glu  Lys Glu Asn Gly Asn  Leu 
    1145                 1150                 1155     


<210>  96
<211>  2210
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Thr Ala Ala Ala Asn Trp Val Ala Asn Gly Ala Ser Leu Glu Asp 
1               5                   10                  15      


Cys His Ser Asn Leu Phe Ser Leu Ala Glu Leu Thr Gly Ile Lys Trp 
            20                  25                  30          


Arg Arg Tyr Asn Phe Gly Gly His Gly Asp Cys Gly Pro Ile Ile Ser 
        35                  40                  45              


Ala Pro Ala Gln Asp Asp Pro Ile Leu Leu Ser Phe Ile Arg Cys Leu 
    50                  55                  60                  


Gln Ala Asn Leu Leu Cys Val Trp Arg Arg Asp Val Lys Pro Asp Cys 
65                  70                  75                  80  


Lys Glu Leu Trp Ile Phe Trp Trp Gly Asp Glu Pro Asn Leu Val Gly 
                85                  90                  95      


Val Ile His His Glu Leu Gln Val Val Glu Glu Gly Leu Trp Glu Asn 
            100                 105                 110         


Gly Leu Ser Tyr Glu Cys Arg Thr Leu Leu Phe Lys Ala Ile His Asn 
        115                 120                 125             


Leu Leu Glu Arg Cys Leu Met Asp Lys Asn Phe Val Arg Ile Gly Lys 
    130                 135                 140                 


Trp Phe Val Arg Pro Tyr Glu Lys Asp Glu Lys Pro Val Asn Lys Ser 
145                 150                 155                 160 


Glu His Leu Ser Cys Ala Phe Thr Phe Phe Leu His Gly Glu Ser Asn 
                165                 170                 175     


Val Cys Thr Ser Val Glu Ile Ala Gln His Gln Pro Ile Tyr Leu Ile 
            180                 185                 190         


Asn Glu Glu His Ile His Met Ala Gln Ser Ser Pro Ala Pro Phe Gln 
        195                 200                 205             


Val Leu Val Ser Pro Tyr Gly Leu Asn Gly Thr Leu Thr Gly Gln Ala 
    210                 215                 220                 


Tyr Lys Met Ser Asp Pro Ala Thr Arg Lys Leu Ile Glu Glu Trp Gln 
225                 230                 235                 240 


Tyr Phe Tyr Pro Met Val Leu Lys Lys Lys Glu Glu Ser Lys Glu Glu 
                245                 250                 255     


Asp Glu Leu Gly Tyr Asp Asp Asp Phe Pro Val Ala Val Glu Val Ile 
            260                 265                 270         


Val Gly Gly Val Arg Met Val Tyr Pro Ser Ala Phe Val Leu Ile Ser 
        275                 280                 285             


Gln Asn Asp Ile Pro Val Pro Gln Ser Val Ala Ser Ala Gly Gly His 
    290                 295                 300                 


Ile Ala Val Gly Gln Gln Gly Leu Gly Ser Val Lys Asp Pro Ser Asn 
305                 310                 315                 320 


Cys Gly Met Pro Leu Thr Pro Pro Thr Ser Pro Glu Gln Ala Ile Leu 
                325                 330                 335     


Gly Glu Ser Gly Gly Met Gln Ser Ala Ala Ser His Leu Val Ser Gln 
            340                 345                 350         


Asp Gly Gly Met Ile Thr Met His Ser Pro Lys Arg Ser Gly Lys Ile 
        355                 360                 365             


Pro Pro Lys Leu His Asn His Met Val His Arg Val Trp Lys Glu Cys 
    370                 375                 380                 


Ile Leu Asn Arg Thr Gln Ser Lys Arg Ser Gln Met Ser Thr Pro Thr 
385                 390                 395                 400 


Leu Glu Glu Glu Pro Ala Ser Asn Pro Ala Thr Trp Asp Phe Val Asp 
                405                 410                 415     


Pro Thr Gln Arg Val Ser Cys Ser Cys Ser Arg His Lys Leu Leu Lys 
            420                 425                 430         


Arg Cys Ala Val Gly Pro Asn Arg Pro Pro Thr Val Ser Gln Pro Gly 
        435                 440                 445             


Phe Ser Ala Gly Pro Ser Ser Ser Ser Ser Leu Pro Pro Pro Ala Ser 
    450                 455                 460                 


Ser Lys His Lys Thr Ala Glu Arg Gln Glu Lys Gly Asp Lys Leu Gln 
465                 470                 475                 480 


Lys Arg Pro Leu Ile Pro Phe His His Arg Pro Ser Val Ala Glu Glu 
                485                 490                 495     


Leu Cys Met Glu Gln Asp Thr Pro Gly Gln Lys Leu Gly Leu Ala Gly 
            500                 505                 510         


Ile Asp Ser Ser Leu Glu Val Ser Ser Ser Arg Lys Tyr Asp Lys Gln 
        515                 520                 525             


Met Ala Val Pro Ser Arg Asn Thr Ser Lys Gln Met Asn Leu Asn Pro 
    530                 535                 540                 


Met Asp Ser Pro His Ser Pro Ile Ser Pro Leu Pro Pro Thr Leu Ser 
545                 550                 555                 560 


Pro Gln Pro Arg Gly Gln Glu Thr Glu Ser Leu Asp Pro Pro Ser Val 
                565                 570                 575     


Pro Val Asn Pro Ala Leu Tyr Gly Asn Gly Leu Glu Leu Gln Gln Leu 
            580                 585                 590         


Ser Thr Leu Asp Asp Arg Thr Val Leu Val Gly Gln Arg Leu Pro Leu 
        595                 600                 605             


Met Ala Glu Val Ser Glu Thr Ala Leu Tyr Cys Gly Ile Arg Pro Ser 
    610                 615                 620                 


Asn Pro Glu Ser Ser Glu Lys Trp Trp His Ser Tyr Arg Leu Pro Pro 
625                 630                 635                 640 


Ser Asp Asp Ala Glu Phe Arg Pro Pro Glu Leu Gln Gly Glu Arg Cys 
                645                 650                 655     


Asp Ala Lys Met Glu Val Asn Ser Glu Ser Thr Ala Leu Gln Arg Leu 
            660                 665                 670         


Leu Ala Gln Pro Asn Lys Arg Phe Lys Ile Trp Gln Asp Lys Gln Pro 
        675                 680                 685             


Gln Leu Gln Pro Leu His Phe Leu Asp Pro Leu Pro Leu Ser Gln Gln 
    690                 695                 700                 


Pro Gly Asp Ser Leu Gly Glu Val Asn Asp Pro Tyr Thr Phe Glu Asp 
705                 710                 715                 720 


Gly Asp Ile Lys Tyr Ile Phe Thr Ala Asn Lys Lys Cys Lys Gln Gly 
                725                 730                 735     


Thr Glu Lys Asp Ser Leu Lys Lys Asn Lys Ser Glu Asp Gly Phe Gly 
            740                 745                 750         


Thr Lys Asp Val Thr Thr Pro Gly His Ser Thr Pro Val Pro Asp Gly 
        755                 760                 765             


Lys Asn Ala Met Ser Ile Phe Ser Ser Ala Thr Lys Thr Asp Val Arg 
    770                 775                 780                 


Gln Asp Asn Ala Ala Gly Arg Ala Gly Ser Ser Ser Leu Thr Gln Val 
785                 790                 795                 800 


Thr Asp Leu Ala Pro Ser Leu His Asp Leu Asp Asn Ile Phe Asp Asn 
                805                 810                 815     


Ser Asp Asp Asp Glu Leu Gly Ala Val Ser Pro Ala Leu Arg Ser Ser 
            820                 825                 830         


Lys Met Pro Ala Val Gly Thr Glu Asp Arg Pro Leu Gly Lys Asp Gly 
        835                 840                 845             


Arg Ala Ala Val Pro Tyr Pro Pro Thr Val Ala Asp Leu Gln Arg Met 
    850                 855                 860                 


Phe Pro Thr Pro Pro Ser Leu Glu Gln His Pro Ala Phe Ser Pro Val 
865                 870                 875                 880 


Met Asn Tyr Lys Asp Gly Ile Ser Ser Glu Thr Val Thr Ala Leu Gly 
                885                 890                 895     


Met Met Glu Ser Pro Met Val Ser Met Val Ser Thr Gln Leu Thr Glu 
            900                 905                 910         


Phe Lys Met Glu Val Glu Asp Gly Leu Gly Ser Pro Lys Pro Glu Glu 
        915                 920                 925             


Ile Lys Asp Phe Ser Tyr Val His Lys Val Pro Ser Phe Gln Pro Phe 
    930                 935                 940                 


Val Gly Ser Ser Met Phe Ala Pro Leu Lys Met Leu Pro Ser His Cys 
945                 950                 955                 960 


Leu Leu Pro Leu Lys Ile Pro Asp Ala Cys Leu Phe Arg Pro Ser Trp 
                965                 970                 975     


Ala Ile Pro Pro Lys Ile Glu Gln Leu Pro Met Pro Pro Ala Ala Thr 
            980                 985                 990         


Phe Ile Arg Asp Gly Tyr Asn Asn  Val Pro Ser Val Gly  Ser Leu Ala 
        995                 1000                 1005             


Asp Pro  Asp Tyr Leu Asn Thr  Pro Gln Met Asn Thr  Pro Val Thr 
    1010                 1015                 1020             


Leu Asn  Ser Ala Ala Pro Ala  Ser Asn Ser Gly Ala  Gly Val Leu 
    1025                 1030                 1035             


Pro Ser  Pro Ala Thr Pro Arg  Phe Ser Val Pro Thr  Pro Arg Thr 
    1040                 1045                 1050             


Pro Arg  Thr Pro Arg Thr Pro  Arg Gly Gly Gly Thr  Ala Ser Gly 
    1055                 1060                 1065             


Gln Gly  Ser Val Lys Tyr Asp  Ser Thr Asp Gln Gly  Ser Pro Ala 
    1070                 1075                 1080             


Ser Thr  Pro Ser Thr Thr Arg  Pro Leu Asn Ser Val  Glu Pro Ala 
    1085                 1090                 1095             


Thr Met  Gln Pro Ile Pro Glu  Ala His Ser Leu Tyr  Val Thr Leu 
    1100                 1105                 1110             


Ile Leu  Ser Asp Ser Val Met  Asn Ile Phe Lys Asp  Arg Asn Phe 
    1115                 1120                 1125             


Asp Ser  Cys Cys Ile Cys Ala  Cys Asn Met Asn Ile  Lys Gly Ala 
    1130                 1135                 1140             


Asp Val  Gly Leu Tyr Ile Pro  Asp Ser Ser Asn Glu  Asp Gln Tyr 
    1145                 1150                 1155             


Arg Cys  Thr Cys Gly Phe Ser  Ala Ile Met Asn Arg  Lys Leu Gly 
    1160                 1165                 1170             


Tyr Asn  Ser Gly Leu Phe Leu  Glu Asp Glu Leu Asp  Ile Phe Gly 
    1175                 1180                 1185             


Lys Asn  Ser Asp Ile Gly Gln  Ala Ala Glu Arg Arg  Leu Met Met 
    1190                 1195                 1200             


Cys Gln  Ser Thr Phe Leu Pro  Gln Val Glu Gly Thr  Lys Lys Pro 
    1205                 1210                 1215             


Gln Glu  Pro Pro Ile Ser Leu  Leu Leu Leu Leu Gln  Asn Gln His 
    1220                 1225                 1230             


Thr Gln  Pro Phe Ala Ser Leu  Asn Phe Leu Asp Tyr  Ile Ser Ser 
    1235                 1240                 1245             


Asn Asn  Arg Gln Thr Leu Pro  Cys Val Ser Trp Ser  Tyr Asp Arg 
    1250                 1255                 1260             


Val Gln  Ala Asp Asn Asn Asp  Tyr Trp Thr Glu Cys  Phe Asn Ala 
    1265                 1270                 1275             


Leu Glu  Gln Gly Arg Gln Tyr  Val Asp Asn Pro Thr  Gly Gly Lys 
    1280                 1285                 1290             


Val Asp  Glu Ala Leu Val Arg  Ser Ala Thr Val His  Ser Trp Pro 
    1295                 1300                 1305             


His Ser  Asn Val Leu Asp Ile  Ser Met Leu Ser Ser  Gln Asp Val 
    1310                 1315                 1320             


Val Arg  Met Leu Leu Ser Leu  Gln Pro Phe Leu Gln  Asp Ala Ile 
    1325                 1330                 1335             


Gln Lys  Lys Arg Thr Gly Arg  Thr Trp Glu Asn Ile  Gln His Val 
    1340                 1345                 1350             


Gln Gly  Pro Leu Thr Trp Gln  Gln Phe His Lys Met  Ala Gly Arg 
    1355                 1360                 1365             


Gly Thr  Tyr Gly Ser Glu Glu  Ser Pro Glu Pro Leu  Pro Ile Pro 
    1370                 1375                 1380             


Thr Leu  Leu Val Gly Tyr Asp  Lys Asp Phe Leu Thr  Ile Ser Pro 
    1385                 1390                 1395             


Phe Ser  Leu Pro Phe Trp Glu  Arg Leu Leu Leu Asp  Pro Tyr Gly 
    1400                 1405                 1410             


Gly His  Arg Asp Val Ala Tyr  Ile Val Val Cys Pro  Glu Asn Glu 
    1415                 1420                 1425             


Ala Leu  Leu Glu Gly Ala Lys  Thr Phe Phe Arg Asp  Leu Ser Ala 
    1430                 1435                 1440             


Val Tyr  Glu Met Cys Arg Leu  Gly Gln His Lys Pro  Ile Cys Lys 
    1445                 1450                 1455             


Val Leu  Arg Asp Gly Ile Met  Arg Val Gly Lys Thr  Val Ala Gln 
    1460                 1465                 1470             


Lys Leu  Thr Asp Glu Leu Val  Ser Glu Trp Phe Asn  Gln Pro Trp 
    1475                 1480                 1485             


Ser Gly  Glu Glu Asn Asp Asn  His Ser Arg Leu Lys  Leu Tyr Ala 
    1490                 1495                 1500             


Gln Val  Cys Arg His His Leu  Ala Pro Tyr Leu Ala  Thr Leu Gln 
    1505                 1510                 1515             


Leu Asp  Ser Ser Leu Leu Ile  Pro Pro Lys Tyr Gln  Thr Pro Pro 
    1520                 1525                 1530             


Ala Ala  Ala Gln Gly Gln Ala  Thr Pro Gly Asn Ala  Gly Pro Leu 
    1535                 1540                 1545             


Ala Pro  Asn Gly Ser Ala Ala  Pro Pro Ala Gly Ser  Ala Phe Asn 
    1550                 1555                 1560             


Pro Thr  Ser Asn Ser Ser Ser  Thr Asn Pro Ala Ala  Ser Ser Ser 
    1565                 1570                 1575             


Ala Ser  Gly Ser Ser Val Pro  Pro Val Ser Ser Ser  Ala Ser Ala 
    1580                 1585                 1590             


Pro Gly  Ile Ser Gln Ile Ser  Thr Thr Ser Ser Ser  Gly Phe Ser 
    1595                 1600                 1605             


Gly Ser  Val Gly Gly Gln Asn  Pro Ser Thr Gly Gly  Ile Ser Ala 
    1610                 1615                 1620             


Asp Arg  Thr Gln Gly Asn Ile  Gly Cys Gly Gly Asp  Thr Asp Pro 
    1625                 1630                 1635             


Gly Gln  Ser Ser Ser Gln Pro  Ser Gln Asp Gly Gln  Glu Ser Val 
    1640                 1645                 1650             


Thr Glu  Arg Glu Arg Ile Gly  Ile Pro Thr Glu Pro  Asp Ser Ala 
    1655                 1660                 1665             


Asp Ser  His Ala His Pro Pro  Ala Val Val Ile Tyr  Met Val Asp 
    1670                 1675                 1680             


Pro Phe  Thr Tyr Ala Ala Glu  Glu Asp Ser Thr Ser  Gly Asn Phe 
    1685                 1690                 1695             


Trp Leu  Leu Ser Leu Met Arg  Cys Tyr Thr Glu Met  Leu Asp Asn 
    1700                 1705                 1710             


Leu Pro  Glu His Met Arg Asn  Ser Phe Ile Leu Gln  Ile Val Pro 
    1715                 1720                 1725             


Cys Gln  Tyr Met Leu Gln Thr  Met Lys Asp Glu Gln  Val Phe Tyr 
    1730                 1735                 1740             


Ile Gln  Tyr Leu Lys Ser Met  Ala Phe Ser Val Tyr  Cys Gln Cys 
    1745                 1750                 1755             


Arg Arg  Pro Leu Pro Thr Gln  Ile His Ile Lys Ser  Leu Thr Gly 
    1760                 1765                 1770             


Phe Gly  Pro Ala Ala Ser Ile  Glu Met Thr Leu Lys  Asn Pro Glu 
    1775                 1780                 1785             


Arg Pro  Ser Pro Ile Gln Leu  Tyr Ser Pro Pro Phe  Ile Leu Ala 
    1790                 1795                 1800             


Pro Ile  Lys Asp Lys Gln Thr  Glu Leu Gly Glu Thr  Phe Gly Glu 
    1805                 1810                 1815             


Ala Ser  Gln Lys Tyr Asn Val  Leu Phe Val Gly Tyr  Cys Leu Ser 
    1820                 1825                 1830             


His Asp  Gln Arg Trp Leu Leu  Ala Ser Cys Thr Asp  Leu His Gly 
    1835                 1840                 1845             


Glu Leu  Leu Glu Thr Cys Val  Val Asn Ile Ala Leu  Pro Asn Arg 
    1850                 1855                 1860             


Ser Arg  Arg Ser Lys Val Ser  Ala Arg Lys Ile Gly  Leu Gln Lys 
    1865                 1870                 1875             


Leu Trp  Glu Trp Cys Ile Gly  Ile Val Gln Met Thr  Ser Leu Pro 
    1880                 1885                 1890             


Trp Arg  Val Val Ile Gly Arg  Leu Gly Arg Leu Gly  His Gly Glu 
    1895                 1900                 1905             


Leu Lys  Asp Trp Ser Ile Leu  Leu Gly Glu Cys Ser  Leu Gln Thr 
    1910                 1915                 1920             


Ile Ser  Lys Lys Leu Lys Asp  Val Cys Arg Met Cys  Gly Ile Ser 
    1925                 1930                 1935             


Ala Ala  Asp Ser Pro Ser Ile  Leu Ser Ala Cys Leu  Val Ala Met 
    1940                 1945                 1950             


Glu Pro  Gln Gly Ser Phe Val  Val Met Pro Asp Ala  Val Thr Met 
    1955                 1960                 1965             


Gly Ser  Val Phe Gly Arg Ser  Thr Ala Leu Asn Met  Gln Ser Ser 
    1970                 1975                 1980             


Gln Leu  Asn Thr Pro Gln Asp  Ala Ser Cys Thr His  Ile Leu Val 
    1985                 1990                 1995             


Phe Pro  Thr Ser Ser Thr Ile  Gln Val Ala Pro Ala  Asn Tyr Pro 
    2000                 2005                 2010             


Asn Glu  Asp Gly Phe Ser Pro  Asn Asn Asp Asp Met  Phe Val Asp 
    2015                 2020                 2025             


Leu Pro  Phe Pro Asp Asp Met  Asp Asn Asp Ile Gly  Ile Leu Met 
    2030                 2035                 2040             


Thr Gly  Asn Leu His Ser Ser  Pro Asn Ser Ser Pro  Val Pro Ser 
    2045                 2050                 2055             


Pro Gly  Ser Pro Ser Gly Ile  Gly Val Gly Ser His  Phe Gln His 
    2060                 2065                 2070             


Ser Arg  Ser Gln Gly Glu Arg  Leu Leu Ser Arg Glu  Ala Pro Glu 
    2075                 2080                 2085             


Glu Leu  Lys Gln Gln Pro Leu  Ala Leu Gly Tyr Phe  Val Ser Thr 
    2090                 2095                 2100             


Ala Lys  Ala Glu Asn Leu Pro  Gln Trp Phe Trp Ser  Ser Cys Pro 
    2105                 2110                 2115             


Gln Ala  Gln Asn Gln Cys Pro  Leu Phe Leu Lys Ala  Ser Leu His 
    2120                 2125                 2130             


His His  Ile Ser Val Ala Gln  Thr Asp Glu Leu Leu  Pro Ala Arg 
    2135                 2140                 2145             


Asn Ser  Gln Arg Val Pro His  Pro Leu Asp Ser Lys  Thr Thr Ser 
    2150                 2155                 2160             


Asp Val  Leu Arg Phe Val Leu  Glu Gln Tyr Asn Ala  Leu Ser Trp 
    2165                 2170                 2175             


Leu Thr  Cys Asn Pro Ala Thr  Gln Asp Arg Thr Ser  Cys Leu Pro 
    2180                 2185                 2190             


Val His  Phe Val Val Leu Thr  Gln Leu Tyr Asn Ala  Ile Met Asn 
    2195                 2200                 2205             


Ile Leu  
    2210 


<210>  97
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Gly Asn Trp Ala Val Asn Glu Gly Leu Ser Ile Phe Val Ile Leu 
1               5                   10                  15      


Val Trp Leu Gly Leu Asn Val Phe Leu Phe Val Trp Tyr Tyr Arg Val 
            20                  25                  30          


Tyr Asp Ile Pro Pro Lys Phe Phe Tyr Thr Arg Lys Leu Leu Gly Ser 
        35                  40                  45              


Ala Leu Ala Leu Ala Arg Ala Pro Ala Ala Cys Leu Asn Phe Asn Cys 
    50                  55                  60                  


Met Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg 
65                  70                  75                  80  


Gly Ser Ser Ala Cys Cys Ser Thr Arg Val Arg Arg Gln Leu Asp Arg 
                85                  90                  95      


Asn Leu Thr Phe His Lys Met Val Ala Trp Met Ile Ala Leu His Ser 
            100                 105                 110         


Ala Ile His Thr Ile Ala His Leu Phe Asn Val Glu Trp Cys Val Asn 
        115                 120                 125             


Ala Arg Val Asn Asn Ser Asp Pro Tyr Ser Val Ala Leu Ser Glu Leu 
    130                 135                 140                 


Gly Asp Arg Gln Asn Glu Ser Tyr Leu Asn Phe Ala Arg Lys Arg Ile 
145                 150                 155                 160 


Lys Asn Pro Glu Gly Gly Leu Tyr Leu Ala Val Thr Leu Leu Ala Gly 
                165                 170                 175     


Ile Thr Gly Val Val Ile Thr Leu Cys Leu Ile Leu Ile Ile Thr Ser 
            180                 185                 190         


Ser Thr Lys Thr Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Thr 
        195                 200                 205             


His His Leu Phe Val Ile Phe Phe Ile Gly Leu Ala Ile His Gly Ala 
    210                 215                 220                 


Glu Arg Ile Val Arg Gly Gln Thr Ala Glu Ser Leu Ala Val His Asn 
225                 230                 235                 240 


Ile Thr Val Cys Glu Gln Lys Ile Ser Glu Trp Gly Lys Ile Lys Glu 
                245                 250                 255     


Cys Pro Ile Pro Gln Phe Ala Gly Asn Pro Pro Met Thr Trp Lys Trp 
            260                 265                 270         


Ile Val Gly Pro Met Phe Leu Tyr Leu Cys Glu Arg Leu Val Arg Phe 
        275                 280                 285             


Trp Arg Ser Gln Gln Lys Val Val Ile Thr Lys Val Val Thr His Pro 
    290                 295                 300                 


Phe Lys Thr Ile Glu Leu Gln Met Lys Lys Lys Gly Phe Lys Met Glu 
305                 310                 315                 320 


Val Gly Gln Tyr Ile Phe Val Lys Cys Pro Lys Val Ser Lys Leu Glu 
                325                 330                 335     


Trp His Pro Phe Thr Leu Thr Ser Ala Pro Glu Glu Asp Phe Phe Ser 
            340                 345                 350         


Ile His Ile Arg Ile Val Gly Asp Trp Thr Glu Gly Leu Phe Asn Ala 
        355                 360                 365             


Cys Gly Cys Asp Lys Gln Glu Phe Gln Asp Ala Trp Lys Leu Pro Lys 
    370                 375                 380                 


Ile Ala Val Asp Gly Pro Phe Gly Thr Ala Ser Glu Asp Val Phe Ser 
385                 390                 395                 400 


Tyr Glu Val Val Met Leu Val Gly Ala Gly Ile Gly Val Thr Pro Phe 
                405                 410                 415     


Ala Ser Ile Leu Lys Ser Val Trp Tyr Lys Tyr Cys Asn Asn Ala Thr 
            420                 425                 430         


Asn Leu Lys Leu Lys Lys Ile Tyr Phe Tyr Trp Leu Cys Arg Asp Thr 
        435                 440                 445             


His Ala Phe Glu Trp Phe Ala Asp Leu Leu Gln Leu Leu Glu Ser Gln 
    450                 455                 460                 


Met Gln Glu Arg Asn Asn Ala Gly Phe Leu Ser Tyr Asn Ile Tyr Leu 
465                 470                 475                 480 


Thr Gly Trp Asp Glu Ser Gln Ala Asn His Phe Ala Val His His Asp 
                485                 490                 495     


Glu Glu Lys Asp Val Ile Thr Gly Leu Lys Gln Lys Thr Leu Tyr Gly 
            500                 505                 510         


Arg Pro Asn Trp Asp Asn Glu Phe Lys Thr Ile Ala Ser Gln His Pro 
        515                 520                 525             


Asn Thr Arg Ile Gly Val Phe Leu Cys Gly Pro Glu Ala Leu Ala Glu 
    530                 535                 540                 


Thr Leu Ser Lys Gln Ser Ile Ser Asn Ser Glu Ser Gly Pro Arg Gly 
545                 550                 555                 560 


Val His Phe Ile Phe Asn Lys Glu Asn Phe 
                565                 570 


<210>  98
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ala Pro Phe Leu Arg Ile Ala Phe Asn Ser Tyr Glu Leu Gly Ser 
1               5                   10                  15      


Leu Gln Ala Glu Asp Glu Ala Asn Gln Pro Phe Cys Ala Val Lys Met 
            20                  25                  30          


Lys Glu Ala Leu Ser Thr Glu Arg Gly Lys Thr Leu Val Gln Lys Lys 
        35                  40                  45              


Pro Thr Met Tyr Pro Glu Trp Lys Ser Thr Phe Asp Ala His Ile Tyr 
    50                  55                  60                  


Glu Gly Arg Val Ile Gln Ile Val Leu Met Arg Ala Ala Glu Glu Pro 
65                  70                  75                  80  


Val Ser Glu Val Thr Val Gly Val Ser Val Leu Ala Glu Arg Cys Lys 
                85                  90                  95      


Lys Asn Asn Gly Lys Ala Glu Phe Trp Leu Asp Leu Gln Pro Gln Ala 
            100                 105                 110         


Lys Val Leu Met Ser Val Gln Tyr Phe Leu Glu Asp Val Asp Cys Lys 
        115                 120                 125             


Gln Ser Met Arg Ser Glu Asp Glu Ala Lys Phe Pro Thr Met Asn Arg 
    130                 135                 140                 


Arg Gly Ala Ile Lys Gln Ala Lys Ile His Tyr Ile Lys Asn His Glu 
145                 150                 155                 160 


Phe Ile Ala Thr Phe Phe Gly Gln Pro Thr Phe Cys Ser Val Cys Lys 
                165                 170                 175     


Asp Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Lys Cys Arg Gln Cys 
            180                 185                 190         


Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Ile Ile Gly Arg Cys 
        195                 200                 205             


Thr Gly Thr Ala Ala Asn Ser Arg Asp Thr Ile Phe Gln Lys Glu Arg 
    210                 215                 220                 


Phe Asn Ile Asp Met Pro His Arg Phe Lys Val His Asn Tyr Met Ser 
225                 230                 235                 240 


Pro Thr Phe Cys Asp His Cys Gly Ser Leu Leu Trp Gly Leu Val Lys 
                245                 250                 255     


Gln Gly Leu Lys Cys Glu Asp Cys Gly Met Asn Val His His Lys Cys 
            260                 265                 270         


Arg Glu Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Leu Ala 
        275                 280                 285             


Glu Ala Leu Asn Gln Val Thr Gln Arg Ala Ser Arg Arg Ser Asp Ser 
    290                 295                 300                 


Ala Ser Ser Glu Pro Val Gly Ile Tyr Gln Gly Phe Glu Lys Lys Thr 
305                 310                 315                 320 


Gly Val Ala Gly Glu Asp Met Gln Asp Asn Ser Gly Thr Tyr Gly Lys 
                325                 330                 335     


Ile Trp Glu Gly Ser Ser Lys Cys Asn Ile Asn Asn Phe Ile Phe His 
            340                 345                 350         


Lys Val Leu Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Gly Glu Leu 
        355                 360                 365             


Lys Gly Arg Gly Glu Tyr Phe Ala Ile Lys Ala Leu Lys Lys Asp Val 
    370                 375                 380                 


Val Leu Ile Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val 
385                 390                 395                 400 


Leu Thr Leu Ala Ala Glu Asn Pro Phe Leu Thr His Leu Ile Cys Thr 
                405                 410                 415     


Phe Gln Thr Lys Asp His Leu Phe Phe Val Met Glu Phe Leu Asn Gly 
            420                 425                 430         


Gly Asp Leu Met Tyr His Ile Gln Asp Lys Gly Arg Phe Glu Leu Tyr 
        435                 440                 445             


Arg Ala Thr Phe Tyr Ala Ala Glu Ile Met Cys Gly Leu Gln Phe Leu 
    450                 455                 460                 


His Ser Lys Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu 
465                 470                 475                 480 


Leu Asp Arg Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys 
                485                 490                 495     


Glu Asn Ile Phe Gly Glu Ser Arg Ala Ser Thr Phe Cys Gly Thr Pro 
            500                 505                 510         


Asp Tyr Ile Ala Pro Glu Ile Leu Gln Gly Leu Lys Tyr Thr Phe Ser 
        515                 520                 525             


Val Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly 
    530                 535                 540                 


Gln Ser Pro Phe His Gly Asp Asp Glu Asp Glu Leu Phe Glu Ser Ile 
545                 550                 555                 560 


Arg Val Asp Thr Pro His Tyr Pro Arg Trp Ile Thr Lys Glu Ser Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Leu Phe Glu Arg Glu Pro Thr Lys Arg Leu Gly 
            580                 585                 590         


Val Thr Gly Asn Ile Lys Ile His Pro Phe Phe Lys Thr Ile Asn Trp 
        595                 600                 605             


Thr Leu Leu Glu Lys Arg Arg Leu Glu Pro Pro Phe Arg Pro Lys Val 
    610                 615                 620                 


Lys Ser Pro Arg Asp Tyr Ser Asn Phe Asp Gln Glu Phe Leu Asn Glu 
625                 630                 635                 640 


Lys Ala Arg Leu Ser Tyr Ser Asp Lys Asn Leu Ile Asp Ser Met Asp 
                645                 650                 655     


Gln Ser Ala Phe Ala Gly Phe Ser Phe Val Asn Pro Lys Phe Glu His 
            660                 665                 670         


Leu Leu Glu Asp 
        675     


<210>  99
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Leu Lys Lys Gly Ala 
    50                  55                  60                  


Thr Leu Lys Ile Thr Leu Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu 
65                  70                  75                  80  


Asn Ile Leu Trp Leu Asp Tyr Lys Asn Ile Cys Lys Val Val Glu Val 
                85                  90                  95      


Gly Ser Lys Ile Tyr Val Asp Asp Gly Leu Ile Ser Leu Gln Val Lys 
            100                 105                 110         


Gln Lys Gly Ala Asp Phe Leu Val Thr Glu Val Glu Asn Gly Gly Ser 
        115                 120                 125             


Leu Gly Ser Lys Lys Gly Val Asn Leu Pro Gly Ala Ala Val Asp Leu 
    130                 135                 140                 


Pro Ala Val Ser Glu Lys Asp Ile Gln Asp Leu Lys Phe Gly Val Glu 
145                 150                 155                 160 


Gln Asp Val Asp Met Val Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp 
                165                 170                 175     


Val His Glu Val Arg Lys Val Leu Gly Glu Lys Gly Lys Asn Ile Lys 
            180                 185                 190         


Ile Ile Ser Lys Ile Glu Asn His Glu Gly Val Arg Arg Phe Asp Glu 
        195                 200                 205             


Ile Leu Glu Ala Ser Asp Gly Ile Met Val Ala Arg Gly Asp Leu Gly 
    210                 215                 220                 


Ile Glu Ile Pro Ala Glu Lys Val Phe Leu Ala Gln Lys Met Met Ile 
225                 230                 235                 240 


Gly Arg Cys Asn Arg Ala Gly Lys Pro Val Ile Cys Ala Thr Gln Met 
                245                 250                 255     


Leu Glu Ser Met Ile Lys Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser 
            260                 265                 270         


Asp Val Ala Asn Ala Val Leu Asp Gly Ala Asp Cys Ile Met Leu Ser 
        275                 280                 285             


Gly Glu Thr Ala Lys Gly Asp Tyr Pro Leu Glu Ala Val Arg Met Gln 
    290                 295                 300                 


His Leu Ile Ala Arg Glu Ala Glu Ala Ala Ile Tyr His Leu Gln Leu 
305                 310                 315                 320 


Phe Glu Glu Leu Arg Arg Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu 
                325                 330                 335     


Ala Thr Ala Val Gly Ala Val Glu Ala Ser Phe Lys Cys Cys Ser Gly 
            340                 345                 350         


Ala Ile Ile Val Leu Thr Lys Ser Gly Arg Ser Ala His Gln Val Ala 
        355                 360                 365             


Arg Tyr Arg Pro Arg Ala Pro Ile Ile Ala Val Thr Arg Asn Pro Gln 
    370                 375                 380                 


Thr Ala Arg Gln Ala His Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys 
385                 390                 395                 400 


Lys Asp Pro Val Gln Glu Ala Trp Ala Glu Asp Val Asp Leu Arg Val 
                405                 410                 415     


Asn Phe Ala Met Asn Val Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly 
            420                 425                 430         


Asp Val Val Ile Val Leu Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr 
        435                 440                 445             


Asn Thr Met Arg Val Val Pro Val Pro 
    450                 455         


<210>  100
<211>  3259
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Leu Ser Arg Leu Ser Gly Leu Ala Asn Val Val Leu His Glu Leu 
1               5                   10                  15      


Ser Gly Asp Asp Asp Thr Asp Gln Asn Met Arg Ala Pro Leu Asp Pro 
            20                  25                  30          


Glu Leu His Gln Glu Ser Asp Met Glu Phe Asn Asn Thr Thr Gln Glu 
        35                  40                  45              


Asp Val Gln Glu Arg Leu Ala Tyr Ala Glu Gln Leu Val Val Glu Leu 
    50                  55                  60                  


Lys Asp Ile Ile Arg Gln Lys Asp Val Gln Leu Gln Gln Lys Asp Glu 
65                  70                  75                  80  


Ala Leu Gln Glu Glu Arg Lys Ala Ala Asp Asn Lys Ile Lys Lys Leu 
                85                  90                  95      


Lys Leu His Ala Lys Ala Lys Leu Thr Ser Leu Asn Lys Tyr Ile Glu 
            100                 105                 110         


Glu Met Lys Ala Gln Gly Gly Thr Val Leu Pro Thr Glu Pro Gln Ser 
        115                 120                 125             


Glu Glu Gln Leu Ser Lys His Asp Lys Ser Ser Thr Glu Glu Glu Met 
    130                 135                 140                 


Glu Ile Glu Lys Ile Lys His Lys Leu Gln Glu Lys Glu Glu Leu Ile 
145                 150                 155                 160 


Ser Thr Leu Gln Ala Gln Leu Thr Gln Ala Gln Ala Glu Gln Pro Ala 
                165                 170                 175     


Gln Ser Ser Thr Glu Met Glu Glu Phe Val Met Met Lys Gln Gln Leu 
            180                 185                 190         


Gln Glu Lys Glu Glu Phe Ile Ser Thr Leu Gln Ala Gln Leu Ser Gln 
        195                 200                 205             


Thr Gln Ala Glu Gln Ala Ala Gln Gln Val Val Arg Glu Lys Asp Ala 
    210                 215                 220                 


Arg Phe Glu Thr Gln Val Arg Leu His Glu Asp Glu Leu Leu Gln Leu 
225                 230                 235                 240 


Val Thr Gln Ala Asp Val Glu Thr Glu Met Gln Gln Lys Leu Arg Val 
                245                 250                 255     


Leu Gln Arg Lys Leu Glu Glu His Glu Glu Ser Leu Val Gly Arg Ala 
            260                 265                 270         


Gln Val Val Asp Leu Leu Gln Gln Glu Leu Thr Ala Ala Glu Gln Arg 
        275                 280                 285             


Asn Gln Ile Leu Ser Gln Gln Leu Gln Gln Met Glu Ala Glu His Asn 
    290                 295                 300                 


Thr Leu Arg Asn Thr Val Glu Thr Glu Arg Glu Glu Ser Lys Ile Leu 
305                 310                 315                 320 


Leu Glu Lys Met Glu Leu Glu Val Ala Glu Arg Lys Leu Ser Phe His 
                325                 330                 335     


Asn Leu Gln Glu Glu Met His His Leu Leu Glu Gln Phe Glu Gln Ala 
            340                 345                 350         


Gly Gln Ala Gln Ala Glu Leu Glu Ser Arg Tyr Ser Ala Leu Glu Gln 
        355                 360                 365             


Lys His Lys Ala Glu Met Glu Glu Lys Thr Ser His Ile Leu Ser Leu 
    370                 375                 380                 


Gln Lys Thr Gly Gln Glu Leu Gln Ser Ala Cys Asp Ala Leu Lys Asp 
385                 390                 395                 400 


Gln Asn Ser Lys Leu Leu Gln Asp Lys Asn Glu Gln Ala Val Gln Ser 
                405                 410                 415     


Ala Gln Thr Ile Gln Gln Leu Glu Asp Gln Leu Gln Gln Lys Ser Lys 
            420                 425                 430         


Glu Ile Ser Gln Phe Leu Asn Arg Leu Pro Leu Gln Gln His Glu Thr 
        435                 440                 445             


Ala Ser Gln Thr Ser Phe Pro Asp Val Tyr Asn Glu Gly Thr Gln Ala 
    450                 455                 460                 


Val Thr Glu Glu Asn Ile Ala Ser Leu Gln Lys Arg Val Val Glu Leu 
465                 470                 475                 480 


Glu Asn Glu Lys Gly Ala Leu Leu Leu Ser Ser Ile Glu Leu Glu Glu 
                485                 490                 495     


Leu Lys Ala Glu Asn Glu Lys Leu Ser Ser Gln Ile Thr Leu Leu Glu 
            500                 505                 510         


Ala Gln Asn Arg Thr Gly Glu Ala Asp Arg Glu Val Ser Glu Ile Ser 
        515                 520                 525             


Ile Val Asp Ile Ala Asn Lys Arg Ser Ser Ser Ala Glu Glu Ser Gly 
    530                 535                 540                 


Gln Asp Val Leu Glu Asn Thr Phe Ser Gln Lys His Lys Glu Leu Ser 
545                 550                 555                 560 


Val Leu Leu Leu Glu Met Lys Glu Ala Gln Glu Glu Ile Ala Phe Leu 
                565                 570                 575     


Lys Leu Gln Leu Gln Gly Lys Arg Ala Glu Glu Ala Asp His Glu Val 
            580                 585                 590         


Leu Asp Gln Lys Glu Met Lys Gln Met Glu Gly Glu Gly Ile Ala Pro 
        595                 600                 605             


Ile Lys Met Lys Val Phe Leu Glu Asp Thr Gly Gln Asp Phe Pro Leu 
    610                 615                 620                 


Met Pro Asn Glu Glu Ser Ser Leu Pro Ala Val Glu Lys Glu Gln Ala 
625                 630                 635                 640 


Ser Thr Glu His Gln Ser Arg Thr Ser Glu Glu Ile Ser Leu Asn Asp 
                645                 650                 655     


Ala Gly Val Glu Leu Lys Ser Thr Lys Gln Asp Gly Asp Lys Ser Leu 
            660                 665                 670         


Ser Ala Val Pro Asp Ile Gly Gln Cys His Gln Asp Glu Leu Glu Arg 
        675                 680                 685             


Leu Lys Ser Gln Ile Leu Glu Leu Glu Leu Asn Phe His Lys Ala Gln 
    690                 695                 700                 


Glu Ile Tyr Glu Lys Asn Leu Asp Glu Lys Ala Lys Glu Ile Ser Asn 
705                 710                 715                 720 


Leu Asn Gln Leu Ile Glu Glu Phe Lys Lys Asn Ala Asp Asn Asn Ser 
                725                 730                 735     


Ser Ala Phe Thr Ala Leu Ser Glu Glu Arg Asp Gln Leu Leu Ser Gln 
            740                 745                 750         


Val Lys Glu Leu Ser Met Val Thr Glu Leu Arg Ala Gln Val Lys Gln 
        755                 760                 765             


Leu Glu Met Asn Leu Ala Glu Ala Glu Arg Gln Arg Arg Leu Asp Tyr 
    770                 775                 780                 


Glu Ser Gln Thr Ala His Asp Asn Leu Leu Thr Glu Gln Ile His Ser 
785                 790                 795                 800 


Leu Ser Ile Glu Ala Lys Ser Lys Asp Val Lys Ile Glu Val Leu Gln 
                805                 810                 815     


Asn Glu Leu Asp Asp Val Gln Leu Gln Phe Ser Glu Gln Ser Thr Leu 
            820                 825                 830         


Ile Arg Ser Leu Gln Ser Gln Leu Gln Asn Lys Glu Ser Glu Val Leu 
        835                 840                 845             


Glu Gly Ala Glu Arg Val Arg His Ile Ser Ser Lys Val Glu Glu Leu 
    850                 855                 860                 


Ser Gln Ala Leu Ser Gln Lys Glu Leu Glu Ile Thr Lys Met Asp Gln 
865                 870                 875                 880 


Leu Leu Leu Glu Lys Lys Arg Asp Val Glu Thr Leu Gln Gln Thr Ile 
                885                 890                 895     


Glu Glu Lys Asp Gln Gln Val Thr Glu Ile Ser Phe Ser Met Thr Glu 
            900                 905                 910         


Lys Met Val Gln Leu Asn Glu Glu Lys Phe Ser Leu Gly Val Glu Ile 
        915                 920                 925             


Lys Thr Leu Lys Glu Gln Leu Asn Leu Leu Ser Arg Ala Glu Glu Ala 
    930                 935                 940                 


Lys Lys Glu Gln Val Glu Glu Asp Asn Glu Val Ser Ser Gly Leu Lys 
945                 950                 955                 960 


Gln Asn Tyr Asp Glu Met Ser Pro Ala Gly Gln Ile Ser Lys Glu Glu 
                965                 970                 975     


Leu Gln His Glu Phe Asp Leu Leu Lys Lys Glu Asn Glu Gln Arg Lys 
            980                 985                 990         


Arg Lys Leu Gln Ala Ala Leu Ile  Asn Arg Lys Glu Leu  Leu Gln Arg 
        995                 1000                 1005             


Val Ser  Arg Leu Glu Glu Glu  Leu Ala Asn Leu Lys  Asp Glu Ser 
    1010                 1015                 1020             


Lys Lys  Glu Ile Pro Leu Ser  Glu Thr Glu Arg Gly  Glu Val Glu 
    1025                 1030                 1035             


Glu Asp  Lys Glu Asn Lys Glu  Tyr Ser Glu Lys Cys  Val Thr Ser 
    1040                 1045                 1050             


Lys Cys  Gln Glu Ile Glu Ile  Tyr Leu Lys Gln Thr  Ile Ser Glu 
    1055                 1060                 1065             


Lys Glu  Val Glu Leu Gln His  Ile Arg Lys Asp Leu  Glu Glu Lys 
    1070                 1075                 1080             


Leu Ala  Ala Glu Glu Gln Phe  Gln Ala Leu Val Lys  Gln Met Asn 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asp Lys Thr  Asn Gln Ile Asp Leu  Leu Gln Ala 
    1100                 1105                 1110             


Glu Ile  Ser Glu Asn Gln Ala  Ile Ile Gln Lys Leu  Ile Thr Ser 
    1115                 1120                 1125             


Asn Thr  Asp Ala Ser Asp Gly  Asp Ser Val Ala Leu  Val Lys Glu 
    1130                 1135                 1140             


Thr Val  Val Ile Ser Pro Pro  Cys Thr Gly Ser Ser  Glu His Trp 
    1145                 1150                 1155             


Lys Pro  Glu Leu Glu Glu Lys  Ile Leu Ala Leu Glu  Lys Glu Lys 
    1160                 1165                 1170             


Glu Gln  Leu Gln Lys Lys Leu  Gln Glu Ala Leu Thr  Ser Arg Lys 
    1175                 1180                 1185             


Ala Ile  Leu Lys Lys Ala Gln  Glu Lys Glu Arg His  Leu Arg Glu 
    1190                 1195                 1200             


Glu Leu  Lys Gln Gln Lys Asp  Asp Tyr Asn Arg Leu  Gln Glu Gln 
    1205                 1210                 1215             


Phe Asp  Glu Gln Ser Lys Glu  Asn Glu Asn Ile Gly  Asp Gln Leu 
    1220                 1225                 1230             


Arg Gln  Leu Gln Ile Gln Val  Arg Glu Ser Ile Asp  Gly Lys Leu 
    1235                 1240                 1245             


Pro Ser  Thr Asp Gln Gln Glu  Ser Cys Ser Ser Thr  Pro Gly Leu 
    1250                 1255                 1260             


Glu Glu  Pro Leu Phe Lys Ala  Thr Glu Gln His His  Thr Gln Pro 
    1265                 1270                 1275             


Val Leu  Glu Ser Asn Leu Cys  Pro Asp Trp Pro Ser  His Ser Glu 
    1280                 1285                 1290             


Asp Ala  Ser Ala Leu Gln Gly  Gly Thr Ser Val Ala  Gln Ile Lys 
    1295                 1300                 1305             


Ala Gln  Leu Lys Glu Ile Glu  Ala Glu Lys Val Glu  Leu Glu Leu 
    1310                 1315                 1320             


Lys Val  Ser Ser Thr Thr Ser  Glu Leu Thr Lys Lys  Ser Glu Glu 
    1325                 1330                 1335             


Val Phe  Gln Leu Gln Glu Gln  Ile Asn Lys Gln Gly  Leu Glu Ile 
    1340                 1345                 1350             


Glu Ser  Leu Lys Thr Val Ser  His Glu Ala Glu Val  His Ala Glu 
    1355                 1360                 1365             


Ser Leu  Gln Gln Lys Leu Glu  Ser Ser Gln Leu Gln  Ile Ala Gly 
    1370                 1375                 1380             


Leu Glu  His Leu Arg Glu Leu  Gln Pro Lys Leu Asp  Glu Leu Gln 
    1385                 1390                 1395             


Lys Leu  Ile Ser Lys Lys Glu  Glu Asp Val Ser Tyr  Leu Ser Gly 
    1400                 1405                 1410             


Gln Leu  Ser Glu Lys Glu Ala  Ala Leu Thr Lys Ile  Gln Thr Glu 
    1415                 1420                 1425             


Ile Ile  Glu Gln Glu Asp Leu  Ile Lys Ala Leu His  Thr Gln Leu 
    1430                 1435                 1440             


Glu Met  Gln Ala Lys Glu His  Asp Glu Arg Ile Lys  Gln Leu Gln 
    1445                 1450                 1455             


Val Glu  Leu Cys Glu Met Lys  Gln Lys Pro Glu Glu  Ile Gly Glu 
    1460                 1465                 1470             


Glu Ser  Arg Ala Lys Gln Gln  Ile Gln Arg Lys Leu  Gln Ala Ala 
    1475                 1480                 1485             


Leu Ile  Ser Arg Lys Glu Ala  Leu Lys Glu Asn Lys  Ser Leu Gln 
    1490                 1495                 1500             


Glu Glu  Leu Ser Leu Ala Arg  Gly Thr Ile Glu Arg  Leu Thr Lys 
    1505                 1510                 1515             


Ser Leu  Ala Asp Val Glu Ser  Gln Val Ser Ala Gln  Asn Lys Glu 
    1520                 1525                 1530             


Lys Asp  Thr Val Leu Gly Arg  Leu Ala Leu Leu Gln  Glu Glu Arg 
    1535                 1540                 1545             


Asp Lys  Leu Ile Thr Glu Met  Asp Arg Ser Leu Leu  Glu Asn Gln 
    1550                 1555                 1560             


Ser Leu  Ser Ser Ser Cys Glu  Ser Leu Lys Leu Ala  Leu Glu Gly 
    1565                 1570                 1575             


Leu Thr  Glu Asp Lys Glu Lys  Leu Val Lys Glu Ile  Glu Ser Leu 
    1580                 1585                 1590             


Lys Ser  Ser Lys Ile Ala Glu  Ser Thr Glu Trp Gln  Glu Lys His 
    1595                 1600                 1605             


Lys Glu  Leu Gln Lys Glu Tyr  Glu Ile Leu Leu Gln  Ser Tyr Glu 
    1610                 1615                 1620             


Asn Val  Ser Asn Glu Ala Glu  Arg Ile Gln His Val  Val Glu Ala 
    1625                 1630                 1635             


Val Arg  Gln Glu Lys Gln Glu  Leu Tyr Gly Lys Leu  Arg Ser Thr 
    1640                 1645                 1650             


Glu Ala  Asn Lys Lys Glu Thr  Glu Lys Gln Leu Gln  Glu Ala Glu 
    1655                 1660                 1665             


Gln Glu  Met Glu Glu Met Lys  Glu Lys Met Arg Lys  Phe Ala Lys 
    1670                 1675                 1680             


Ser Lys  Gln Gln Lys Ile Leu  Glu Leu Glu Glu Glu  Asn Asp Arg 
    1685                 1690                 1695             


Leu Arg  Ala Glu Val His Pro  Ala Gly Asp Thr Ala  Lys Glu Cys 
    1700                 1705                 1710             


Met Glu  Thr Leu Leu Ser Ser  Asn Ala Ser Met Lys  Glu Glu Leu 
    1715                 1720                 1725             


Glu Arg  Val Lys Met Glu Tyr  Glu Thr Leu Ser Lys  Lys Phe Gln 
    1730                 1735                 1740             


Ser Leu  Met Ser Glu Lys Asp  Ser Leu Ser Glu Glu  Val Gln Asp 
    1745                 1750                 1755             


Leu Lys  His Gln Ile Glu Gly  Asn Val Ser Lys Gln  Ala Asn Leu 
    1760                 1765                 1770             


Glu Ala  Thr Glu Lys His Asp  Asn Gln Thr Asn Val  Thr Glu Glu 
    1775                 1780                 1785             


Gly Thr  Gln Ser Ile Pro Gly  Glu Thr Glu Glu Gln  Asp Ser Leu 
    1790                 1795                 1800             


Ser Met  Ser Thr Arg Pro Thr  Cys Ser Glu Ser Val  Pro Ser Ala 
    1805                 1810                 1815             


Lys Ser  Ala Asn Pro Ala Val  Ser Lys Asp Phe Ser  Ser His Asp 
    1820                 1825                 1830             


Glu Ile  Asn Asn Tyr Leu Gln  Gln Ile Asp Gln Leu  Lys Glu Arg 
    1835                 1840                 1845             


Ile Ala  Gly Leu Glu Glu Glu  Lys Gln Lys Asn Lys  Glu Phe Ser 
    1850                 1855                 1860             


Gln Thr  Leu Glu Asn Glu Lys  Asn Thr Leu Leu Ser  Gln Ile Ser 
    1865                 1870                 1875             


Thr Lys  Asp Gly Glu Leu Lys  Met Leu Gln Glu Glu  Val Thr Lys 
    1880                 1885                 1890             


Met Asn  Leu Leu Asn Gln Gln  Ile Gln Glu Glu Leu  Ser Arg Val 
    1895                 1900                 1905             


Thr Lys  Leu Lys Glu Thr Ala  Glu Glu Glu Lys Asp  Asp Leu Glu 
    1910                 1915                 1920             


Glu Arg  Leu Met Asn Gln Leu  Ala Glu Leu Asn Gly  Ser Ile Gly 
    1925                 1930                 1935             


Asn Tyr  Cys Gln Asp Val Thr  Asp Ala Gln Ile Lys  Asn Glu Leu 
    1940                 1945                 1950             


Leu Glu  Ser Glu Met Lys Asn  Leu Lys Lys Cys Val  Ser Glu Leu 
    1955                 1960                 1965             


Glu Glu  Glu Lys Gln Gln Leu  Val Lys Glu Lys Thr  Lys Val Glu 
    1970                 1975                 1980             


Ser Glu  Ile Arg Lys Glu Tyr  Leu Glu Lys Ile Gln  Gly Ala Gln 
    1985                 1990                 1995             


Lys Glu  Pro Gly Asn Lys Ser  His Ala Lys Glu Leu  Gln Glu Leu 
    2000                 2005                 2010             


Leu Lys  Glu Lys Gln Gln Glu  Val Lys Gln Leu Gln  Lys Asp Cys 
    2015                 2020                 2025             


Ile Arg  Tyr Gln Glu Lys Ile  Ser Ala Leu Glu Arg  Thr Val Lys 
    2030                 2035                 2040             


Ala Leu  Glu Phe Val Gln Thr  Glu Ser Gln Lys Asp  Leu Glu Ile 
    2045                 2050                 2055             


Thr Lys  Glu Asn Leu Ala Gln  Ala Val Glu His Arg  Lys Lys Ala 
    2060                 2065                 2070             


Gln Ala  Glu Leu Ala Ser Phe  Lys Val Leu Leu Asp  Asp Thr Gln 
    2075                 2080                 2085             


Ser Glu  Ala Ala Arg Val Leu  Ala Asp Asn Leu Lys  Leu Lys Lys 
    2090                 2095                 2100             


Glu Leu  Gln Ser Asn Lys Glu  Ser Val Lys Ser Gln  Met Lys Gln 
    2105                 2110                 2115             


Lys Asp  Glu Asp Leu Glu Arg  Arg Leu Glu Gln Ala  Glu Glu Lys 
    2120                 2125                 2130             


His Leu  Lys Glu Lys Lys Asn  Met Gln Glu Lys Leu  Asp Ala Leu 
    2135                 2140                 2145             


Arg Arg  Glu Lys Val His Leu  Glu Glu Thr Ile Gly  Glu Ile Gln 
    2150                 2155                 2160             


Val Thr  Leu Asn Lys Lys Asp  Lys Glu Val Gln Gln  Leu Gln Glu 
    2165                 2170                 2175             


Asn Leu  Asp Ser Thr Val Thr  Gln Leu Ala Ala Phe  Thr Lys Ser 
    2180                 2185                 2190             


Met Ser  Ser Leu Gln Asp Asp  Arg Asp Arg Val Ile  Asp Glu Ala 
    2195                 2200                 2205             


Lys Lys  Trp Glu Arg Lys Phe  Ser Asp Ala Ile Gln  Ser Lys Glu 
    2210                 2215                 2220             


Glu Glu  Ile Arg Leu Lys Glu  Asp Asn Cys Ser Val  Leu Lys Asp 
    2225                 2230                 2235             


Gln Leu  Arg Gln Met Ser Ile  His Met Glu Glu Leu  Lys Ile Asn 
    2240                 2245                 2250             


Ile Ser  Arg Leu Glu His Asp  Lys Gln Ile Trp Glu  Ser Lys Ala 
    2255                 2260                 2265             


Gln Thr  Glu Val Gln Leu Gln  Gln Lys Val Cys Asp  Thr Leu Gln 
    2270                 2275                 2280             


Gly Glu  Asn Lys Glu Leu Leu  Ser Gln Leu Glu Glu  Thr Arg His 
    2285                 2290                 2295             


Leu Tyr  His Ser Ser Gln Asn  Glu Leu Ala Lys Leu  Glu Ser Glu 
    2300                 2305                 2310             


Leu Lys  Ser Leu Lys Asp Gln  Leu Thr Asp Leu Ser  Asn Ser Leu 
    2315                 2320                 2325             


Glu Lys  Cys Lys Glu Gln Lys  Gly Asn Leu Glu Gly  Ile Ile Arg 
    2330                 2335                 2340             


Gln Gln  Glu Ala Asp Ile Gln  Asn Ser Lys Phe Ser  Tyr Glu Gln 
    2345                 2350                 2355             


Leu Glu  Thr Asp Leu Gln Ala  Ser Arg Glu Leu Thr  Ser Arg Leu 
    2360                 2365                 2370             


His Glu  Glu Ile Asn Met Lys  Glu Gln Lys Ile Ile  Ser Leu Leu 
    2375                 2380                 2385             


Ser Gly  Lys Glu Glu Ala Ile  Gln Val Ala Ile Ala  Glu Leu Arg 
    2390                 2395                 2400             


Gln Gln  His Asp Lys Glu Ile  Lys Glu Leu Glu Asn  Leu Leu Ser 
    2405                 2410                 2415             


Gln Glu  Glu Glu Glu Asn Ile  Val Leu Glu Glu Glu  Asn Lys Lys 
    2420                 2425                 2430             


Ala Val  Asp Lys Thr Asn Gln  Leu Met Glu Thr Leu  Lys Thr Ile 
    2435                 2440                 2445             


Lys Lys  Glu Asn Ile Gln Gln  Lys Ala Gln Leu Asp  Ser Phe Val 
    2450                 2455                 2460             


Lys Ser  Met Ser Ser Leu Gln  Asn Asp Arg Asp Arg  Ile Val Gly 
    2465                 2470                 2475             


Asp Tyr  Gln Gln Leu Glu Glu  Arg His Leu Ser Ile  Ile Leu Glu 
    2480                 2485                 2490             


Lys Asp  Gln Leu Ile Gln Glu  Ala Ala Ala Glu Asn  Asn Lys Leu 
    2495                 2500                 2505             


Lys Glu  Glu Ile Arg Gly Leu  Arg Ser His Met Asp  Asp Leu Asn 
    2510                 2515                 2520             


Ser Glu  Asn Ala Lys Leu Asp  Ala Glu Leu Ile Gln  Tyr Arg Glu 
    2525                 2530                 2535             


Asp Leu  Asn Gln Val Ile Thr  Ile Lys Asp Ser Gln  Gln Lys Gln 
    2540                 2545                 2550             


Leu Leu  Glu Val Gln Leu Gln  Gln Asn Lys Glu Leu  Glu Asn Lys 
    2555                 2560                 2565             


Tyr Ala  Lys Leu Glu Glu Lys  Leu Lys Glu Ser Glu  Glu Ala Asn 
    2570                 2575                 2580             


Glu Asp  Leu Arg Arg Ser Phe  Asn Ala Leu Gln Glu  Glu Lys Gln 
    2585                 2590                 2595             


Asp Leu  Ser Lys Glu Ile Glu  Ser Leu Lys Val Ser  Ile Ser Gln 
    2600                 2605                 2610             


Leu Thr  Arg Gln Val Thr Ala  Leu Gln Glu Glu Gly  Thr Leu Gly 
    2615                 2620                 2625             


Leu Tyr  His Ala Gln Leu Lys  Val Lys Glu Glu Glu  Val His Arg 
    2630                 2635                 2640             


Leu Ser  Ala Leu Phe Ser Ser  Ser Gln Lys Arg Ile  Ala Glu Leu 
    2645                 2650                 2655             


Glu Glu  Glu Leu Val Cys Val  Gln Lys Glu Ala Ala  Lys Lys Val 
    2660                 2665                 2670             


Gly Glu  Ile Glu Asp Lys Leu  Lys Lys Glu Leu Lys  His Leu His 
    2675                 2680                 2685             


His Asp  Ala Gly Ile Met Arg  Asn Glu Thr Glu Thr  Ala Glu Glu 
    2690                 2695                 2700             


Arg Val  Ala Glu Leu Ala Arg  Asp Leu Val Glu Met  Glu Gln Lys 
    2705                 2710                 2715             


Leu Leu  Met Val Thr Lys Glu  Asn Lys Gly Leu Thr  Ala Gln Ile 
    2720                 2725                 2730             


Gln Ser  Phe Gly Arg Ser Met  Ser Ser Leu Gln Asn  Ser Arg Asp 
    2735                 2740                 2745             


His Ala  Asn Glu Glu Leu Asp  Glu Leu Lys Arg Lys  Tyr Asp Ala 
    2750                 2755                 2760             


Ser Leu  Lys Glu Leu Ala Gln  Leu Lys Glu Gln Gly  Leu Leu Asn 
    2765                 2770                 2775             


Arg Glu  Arg Asp Ala Leu Leu  Ser Glu Thr Ala Phe  Ser Met Asn 
    2780                 2785                 2790             


Ser Thr  Glu Glu Asn Ser Leu  Ser His Leu Glu Lys  Leu Asn Gln 
    2795                 2800                 2805             


Gln Leu  Leu Ser Lys Asp Glu  Gln Leu Leu His Leu  Ser Ser Gln 
    2810                 2815                 2820             


Leu Glu  Asp Ser Tyr Asn Gln  Val Gln Ser Phe Ser  Lys Ala Met 
    2825                 2830                 2835             


Ala Ser  Leu Gln Asn Glu Arg  Asp His Leu Trp Asn  Glu Leu Glu 
    2840                 2845                 2850             


Lys Phe  Arg Lys Ser Glu Glu  Gly Lys Gln Arg Ser  Ala Ala Gln 
    2855                 2860                 2865             


Pro Ser  Thr Ser Pro Ala Glu  Val Gln Ser Leu Lys  Lys Ala Met 
    2870                 2875                 2880             


Ser Ser  Leu Gln Asn Asp Arg  Asp Arg Leu Leu Lys  Glu Leu Lys 
    2885                 2890                 2895             


Asn Leu  Gln Gln Gln Tyr Leu  Gln Ile Asn Gln Glu  Ile Thr Glu 
    2900                 2905                 2910             


Leu His  Pro Leu Lys Ala Gln  Leu Gln Glu Tyr Gln  Asp Lys Thr 
    2915                 2920                 2925             


Lys Ala  Phe Gln Ile Met Gln  Glu Glu Leu Arg Gln  Glu Asn Leu 
    2930                 2935                 2940             


Ser Trp  Gln His Glu Leu His  Gln Leu Arg Met Glu  Lys Ser Ser 
    2945                 2950                 2955             


Trp Glu  Ile His Glu Arg Arg  Met Lys Glu Gln Tyr  Leu Met Ala 
    2960                 2965                 2970             


Ile Ser  Asp Lys Asp Gln Gln  Leu Ser His Leu Gln  Asn Leu Ile 
    2975                 2980                 2985             


Arg Glu  Leu Arg Ser Ser Ser  Ser Gln Thr Gln Pro  Leu Lys Val 
    2990                 2995                 3000             


Gln Tyr  Gln Arg Gln Ala Ser  Pro Glu Thr Ser Ala  Ser Pro Asp 
    3005                 3010                 3015             


Gly Ser  Gln Asn Leu Val Tyr  Glu Thr Glu Leu Leu  Arg Thr Gln 
    3020                 3025                 3030             


Leu Asn  Asp Ser Leu Lys Glu  Ile His Gln Lys Glu  Leu Arg Ile 
    3035                 3040                 3045             


Gln Gln  Leu Asn Ser Asn Phe  Ser Gln Leu Leu Glu  Glu Lys Asn 
    3050                 3055                 3060             


Thr Leu  Ser Ile Gln Leu Cys  Asp Thr Ser Gln Ser  Leu Arg Glu 
    3065                 3070                 3075             


Asn Gln  Gln His Tyr Gly Asp  Leu Leu Asn His Cys  Ala Val Leu 
    3080                 3085                 3090             


Glu Lys  Gln Val Gln Glu Leu  Gln Ala Gly Pro Leu  Asn Ile Asp 
    3095                 3100                 3105             


Val Ala  Pro Gly Ala Pro Gln  Glu Lys Asn Gly Val  His Arg Lys 
    3110                 3115                 3120             


Ser Asp  Pro Glu Glu Leu Arg  Glu Pro Gln Gln Ser  Phe Ser Glu 
    3125                 3130                 3135             


Ala Gln  Gln Gln Leu Cys Asn  Thr Arg Gln Glu Val  Asn Glu Leu 
    3140                 3145                 3150             


Arg Lys  Leu Leu Glu Glu Glu  Arg Asp Gln Arg Val  Ala Ala Glu 
    3155                 3160                 3165             


Asn Ala  Leu Ser Val Ala Glu  Glu Gln Ile Arg Arg  Leu Glu His 
    3170                 3175                 3180             


Ser Glu  Trp Asp Ser Ser Arg  Thr Pro Ile Ile Gly  Ser Cys Gly 
    3185                 3190                 3195             


Thr Gln  Glu Gln Ala Leu Leu  Ile Asp Leu Thr Ser  Asn Ser Cys 
    3200                 3205                 3210             


Arg Arg  Thr Arg Ser Gly Val  Gly Trp Lys Arg Val  Leu Arg Ser 
    3215                 3220                 3225             


Leu Cys  His Ser Arg Thr Arg  Val Pro Leu Leu Ala  Ala Ile Tyr 
    3230                 3235                 3240             


Phe Leu  Met Ile His Val Leu  Leu Ile Leu Cys Phe  Thr Gly His 
    3245                 3250                 3255             


Leu 
    


<210>  101
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ala Leu Glu Lys Ser Leu Val Arg Leu Leu Leu Leu Val Leu Ile 
1               5                   10                  15      


Leu Leu Val Leu Gly Trp Val Gln Pro Ser Leu Gly Lys Glu Ser Arg 
            20                  25                  30          


Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser Pro Ser 
        35                  40                  45              


Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn Met Thr 
    50                  55                  60                  


Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro Leu Val 
65                  70                  75                  80  


Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys Asn Gly 
                85                  90                  95      


Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr Asp Cys 
            100                 105                 110         


Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser 
        115                 120                 125             


Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro Tyr Val 
    130                 135                 140                 


Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
145                 150                 155     


<210>  102
<211>  1941
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Gln Gly Ser Gly Gly Arg Glu Gly Ala Leu Arg Thr Pro Ala 
1               5                   10                  15      


Gly Gly Trp His Ser Pro Pro Ser Pro Asp Met Gln Glu Leu Leu Arg 
            20                  25                  30          


Ser Val Glu Arg Asp Leu Ser Ile Asp Pro Arg Gln Leu Ala Pro Ala 
        35                  40                  45              


Pro Gly Gly Thr His Val Val Ala Leu Val Pro Ala Arg Trp Leu Ala 
    50                  55                  60                  


Ser Leu Arg Asp Arg Arg Leu Pro Leu Gly Pro Cys Pro Arg Ala Glu 
65                  70                  75                  80  


Gly Leu Gly Glu Ala Glu Val Arg Thr Leu Leu Gln Arg Ser Val Gln 
                85                  90                  95      


Arg Leu Pro Ala Gly Trp Thr Arg Val Glu Val His Gly Leu Arg Lys 
            100                 105                 110         


Arg Arg Leu Ser Tyr Pro Leu Gly Gly Gly Leu Pro Phe Glu Asp Gly 
        115                 120                 125             


Ser Cys Gly Pro Glu Thr Leu Thr Arg Phe Met Gln Glu Val Ala Ala 
    130                 135                 140                 


Gln Asn Tyr Arg Asn Leu Trp Arg His Ala Tyr His Thr Tyr Gly Gln 
145                 150                 155                 160 


Pro Tyr Ser His Ser Pro Ala Pro Ser Ala Val Pro Ala Leu Asp Ser 
                165                 170                 175     


Val Arg Gln Ala Leu Gln Arg Val Tyr Gly Cys Ser Phe Leu Pro Val 
            180                 185                 190         


Gly Glu Thr Thr Gln Cys Pro Ser Tyr Ala Arg Glu Gly Pro Cys Pro 
        195                 200                 205             


Pro Arg Gly Ser Pro Ala Cys Pro Ser Leu Leu Arg Ala Glu Ala Leu 
    210                 215                 220                 


Leu Glu Ser Pro Glu Met Leu Tyr Val Val His Pro Tyr Val Gln Phe 
225                 230                 235                 240 


Ser Leu His Asp Val Val Thr Phe Ser Pro Ala Lys Leu Thr Asn Ser 
                245                 250                 255     


Gln Ala Lys Val Leu Phe Ile Leu Phe Arg Val Leu Arg Ala Met Asp 
            260                 265                 270         


Ala Cys His Arg Gln Gly Leu Ala Cys Gly Ala Leu Ser Leu Tyr His 
        275                 280                 285             


Ile Ala Val Asp Glu Lys Leu Cys Ser Glu Leu Arg Leu Asp Leu Ser 
    290                 295                 300                 


Ala Tyr Glu Arg Pro Glu Glu Asp Glu Asn Glu Glu Ala Pro Val Ala 
305                 310                 315                 320 


Arg Asp Glu Ala Gly Ile Val Ser Gln Glu Glu Gln Gly Gly Gln Pro 
                325                 330                 335     


Gly Gln Pro Thr Gly Gln Glu Glu Leu Arg Ser Leu Val Leu Asp Trp 
            340                 345                 350         


Val His Gly Arg Ile Ser Asn Phe His Tyr Leu Met Gln Leu Asn Arg 
        355                 360                 365             


Leu Ala Gly Arg Arg Gln Gly Asp Pro Asn Tyr His Pro Val Leu Pro 
    370                 375                 380                 


Trp Val Val Asp Phe Thr Thr Pro His Gly Arg Phe Arg Asp Leu Arg 
385                 390                 395                 400 


Lys Ser Lys Phe Arg Leu Asn Lys Gly Asp Lys Gln Leu Asp Phe Thr 
                405                 410                 415     


Tyr Glu Met Thr Arg Gln Ala Phe Val Ala Gly Gly Ala Gly Gly Gly 
            420                 425                 430         


Glu Pro Pro His Val Pro His His Ile Ser Asp Val Leu Ser Asp Ile 
        435                 440                 445             


Thr Tyr Tyr Val Tyr Lys Ala Arg Arg Thr Pro Arg Ser Val Leu Cys 
    450                 455                 460                 


Gly His Val Arg Ala Gln Trp Glu Pro His Glu Tyr Pro Ala Ser Met 
465                 470                 475                 480 


Glu Arg Met Gln Asn Trp Thr Pro Asp Glu Cys Ile Pro Glu Phe Tyr 
                485                 490                 495     


Thr Asp Pro Ser Ile Phe Arg Ser Ile His Pro Asp Met Pro Asp Leu 
            500                 505                 510         


Asp Val Pro Ala Trp Cys Ser Ser Ser Gln Glu Phe Val Ala Ala His 
        515                 520                 525             


Arg Ala Leu Leu Glu Ser Arg Glu Val Ser Arg Asp Leu His His Trp 
    530                 535                 540                 


Ile Asp Leu Thr Phe Gly Tyr Lys Leu Gln Gly Lys Glu Ala Val Lys 
545                 550                 555                 560 


Glu Lys Asn Val Cys Leu His Leu Val Asp Ala His Thr His Leu Ala 
                565                 570                 575     


Ser Tyr Gly Val Val Gln Leu Phe Asp Gln Pro His Pro Gln Arg Leu 
            580                 585                 590         


Ala Gly Ala Pro Ala Leu Ala Pro Glu Pro Pro Leu Ile Pro Lys Leu 
        595                 600                 605             


Leu Val Gln Thr Ile Gln Glu Thr Thr Gly Arg Glu Asp Phe Thr Glu 
    610                 615                 620                 


Asn Pro Gly Gln Leu Pro Asn Gly Val Gly Arg Pro Val Leu Glu Ala 
625                 630                 635                 640 


Thr Pro Cys Glu Ala Ser Trp Thr Arg Asp Arg Pro Val Ala Gly Glu 
                645                 650                 655     


Asp Asp Leu Glu Gln Ala Thr Glu Ala Leu Asp Ser Ile Ser Leu Ala 
            660                 665                 670         


Gly Lys Ala Gly Asp Gln Leu Gly Ser Ser Ser Gln Ala Ser Pro Gly 
        675                 680                 685             


Leu Leu Ser Phe Ser Val Ala Ser Ala Ser Arg Pro Gly Arg Arg Asn 
    690                 695                 700                 


Lys Ala Ala Gly Ala Asp Pro Gly Glu Gly Glu Glu Gly Arg Ile Leu 
705                 710                 715                 720 


Leu Pro Glu Gly Phe Asn Pro Met Gln Ala Leu Glu Glu Leu Glu Lys 
                725                 730                 735     


Thr Gly Asn Phe Leu Ala Lys Gly Leu Gly Gly Leu Leu Glu Val Pro 
            740                 745                 750         


Glu Gln Pro Arg Val Gln Pro Ala Val Pro Leu Gln Cys Leu Leu His 
        755                 760                 765             


Arg Asp Met Gln Ala Leu Gly Val Leu Leu Ala Glu Met Val Phe Ala 
    770                 775                 780                 


Thr Arg Val Arg Thr Leu Gln Pro Asp Ala Pro Leu Trp Val Arg Phe 
785                 790                 795                 800 


Gln Ala Val Arg Gly Leu Cys Thr Arg His Pro Lys Glu Val Pro Val 
                805                 810                 815     


Ser Leu Gln Pro Val Leu Asp Thr Leu Leu Gln Met Ser Gly Pro Glu 
            820                 825                 830         


Val Pro Met Gly Ala Glu Arg Gly Lys Leu Asp Gln Leu Phe Glu Tyr 
        835                 840                 845             


Arg Pro Val Ser Gln Gly Leu Pro Pro Pro Cys Pro Ser Gln Leu Leu 
    850                 855                 860                 


Ser Pro Phe Ser Ser Val Val Pro Phe Pro Pro Tyr Phe Pro Ala Leu 
865                 870                 875                 880 


His Arg Phe Ile Leu Leu Tyr Gln Ala Arg Arg Val Glu Asp Glu Ala 
                885                 890                 895     


Gln Gly Arg Glu Leu Val Phe Ala Leu Trp Gln Gln Leu Gly Ala Val 
            900                 905                 910         


Leu Lys Asp Ile Thr Pro Glu Gly Leu Glu Ile Leu Leu Pro Phe Val 
        915                 920                 925             


Leu Ser Leu Met Ser Glu Glu His Thr Ala Val Tyr Thr Ala Trp Tyr 
    930                 935                 940                 


Leu Phe Glu Pro Val Ala Lys Ala Leu Gly Pro Lys Asn Ala Asn Lys 
945                 950                 955                 960 


Tyr Leu Leu Lys Pro Leu Ile Gly Ala Tyr Glu Ser Pro Cys Gln Leu 
                965                 970                 975     


His Gly Arg Phe Tyr Leu Tyr Thr Asp Cys Phe Val Ala Gln Leu Met 
            980                 985                 990         


Val Arg Leu Gly Leu Gln Ala Phe  Leu Thr His Leu Leu  Pro His Val 
        995                 1000                 1005             


Leu Gln  Val Leu Ala Gly Ala  Glu Ala Ser Gln Glu  Glu Ser Lys 
    1010                 1015                 1020             


Asp Leu  Ala Gly Ala Ala Glu  Glu Glu Glu Ser Gly  Leu Pro Gly 
    1025                 1030                 1035             


Ala Gly  Pro Gly Ser Cys Ala  Phe Gly Glu Glu Ile  Pro Met Asp 
    1040                 1045                 1050             


Gly Glu  Pro Pro Ala Ser Ser  Gly Leu Gly Leu Pro  Asp Tyr Thr 
    1055                 1060                 1065             


Ser Gly  Val Ser Phe His Asp  Gln Ala Asp Leu Pro  Glu Thr Glu 
    1070                 1075                 1080             


Asp Phe  Gln Ala Gly Leu Tyr  Val Thr Glu Ser Pro  Gln Pro Gln 
    1085                 1090                 1095             


Glu Ala  Glu Ala Val Ser Leu  Gly Arg Leu Ser Asp  Lys Ser Ser 
    1100                 1105                 1110             


Thr Ser  Glu Thr Ser Leu Gly  Glu Glu Arg Ala Pro  Asp Glu Gly 
    1115                 1120                 1125             


Gly Ala  Pro Val Asp Lys Ser  Ser Leu Arg Ser Gly  Asp Ser Ser 
    1130                 1135                 1140             


Gln Asp  Leu Lys Gln Ser Glu  Gly Ser Glu Glu Glu  Glu Glu Glu 
    1145                 1150                 1155             


Glu Asp  Ser Cys Val Val Leu  Glu Glu Glu Glu Gly  Glu Gln Glu 
    1160                 1165                 1170             


Glu Val  Thr Gly Ala Ser Glu  Leu Thr Leu Ser Asp  Thr Val Leu 
    1175                 1180                 1185             


Ser Met  Glu Thr Val Val Ala  Gly Gly Ser Gly Gly  Asp Gly Glu 
    1190                 1195                 1200             


Glu Glu  Glu Glu Ala Leu Pro  Glu Gln Ser Glu Gly  Lys Glu Gln 
    1205                 1210                 1215             


Lys Ile  Leu Leu Asp Thr Ala  Cys Lys Met Val Arg  Trp Leu Ser 
    1220                 1225                 1230             


Ala Lys  Leu Gly Pro Thr Val  Ala Ser Arg His Val  Ala Arg Asn 
    1235                 1240                 1245             


Leu Leu  Arg Leu Leu Thr Ser  Cys Tyr Val Gly Pro  Thr Arg Gln 
    1250                 1255                 1260             


Gln Phe  Thr Val Ser Ser Gly  Glu Ser Pro Pro Leu  Ser Ala Gly 
    1265                 1270                 1275             


Asn Ile  Tyr Gln Lys Arg Pro  Val Leu Gly Asp Ile  Val Ser Gly 
    1280                 1285                 1290             


Pro Val  Leu Ser Cys Leu Leu  His Ile Ala Arg Leu  Tyr Gly Glu 
    1295                 1300                 1305             


Pro Val  Leu Thr Tyr Gln Tyr  Leu Pro Tyr Ile Ser  Tyr Leu Val 
    1310                 1315                 1320             


Ala Pro  Gly Ser Ala Ser Gly  Pro Ser Arg Leu Asn  Ser Arg Lys 
    1325                 1330                 1335             


Glu Ala  Gly Leu Leu Ala Ala  Val Thr Leu Thr Gln  Lys Ile Ile 
    1340                 1345                 1350             


Val Tyr  Leu Ser Asp Thr Thr  Leu Met Asp Ile Leu  Pro Arg Ile 
    1355                 1360                 1365             


Ser His  Glu Val Leu Leu Pro  Val Leu Ser Phe Leu  Thr Ser Leu 
    1370                 1375                 1380             


Val Thr  Gly Phe Pro Ser Gly  Ala Gln Ala Arg Thr  Ile Leu Cys 
    1385                 1390                 1395             


Val Lys  Thr Ile Ser Leu Ile  Ala Leu Ile Cys Leu  Arg Ile Gly 
    1400                 1405                 1410             


Gln Glu  Met Val Gln Gln His  Leu Ser Glu Pro Val  Ala Thr Phe 
    1415                 1420                 1425             


Phe Gln  Val Phe Ser Gln Leu  His Glu Leu Arg Gln  Gln Asp Leu 
    1430                 1435                 1440             


Lys Leu  Asp Pro Ala Gly Arg  Gly Glu Gly Gln Leu  Pro Gln Val 
    1445                 1450                 1455             


Val Phe  Ser Asp Gly Gln Gln  Arg Pro Val Asp Pro  Ala Leu Leu 
    1460                 1465                 1470             


Asp Glu  Leu Gln Lys Val Phe  Thr Leu Glu Met Ala  Tyr Thr Ile 
    1475                 1480                 1485             


Tyr Val  Pro Phe Ser Cys Leu  Leu Gly Asp Ile Ile  Arg Lys Ile 
    1490                 1495                 1500             


Ile Pro  Asn His Glu Leu Val  Gly Glu Leu Ala Ala  Leu Tyr Leu 
    1505                 1510                 1515             


Glu Ser  Ile Ser Pro Ser Ser  Arg Asn Pro Ala Ser  Val Glu Pro 
    1520                 1525                 1530             


Thr Met  Pro Gly Thr Gly Pro  Glu Trp Asp Pro His  Gly Gly Gly 
    1535                 1540                 1545             


Cys Pro  Gln Asp Asp Gly His  Ser Gly Thr Phe Gly  Ser Val Leu 
    1550                 1555                 1560             


Val Gly  Asn Arg Ile Gln Ile  Pro Asn Asp Ser Arg  Pro Glu Asn 
    1565                 1570                 1575             


Pro Gly  Pro Leu Gly Pro Ile  Ser Gly Val Gly Gly  Gly Gly Leu 
    1580                 1585                 1590             


Gly Ser  Gly Ser Asp Asp Asn  Ala Leu Lys Gln Glu  Leu Pro Arg 
    1595                 1600                 1605             


Ser Val  His Gly Leu Ser Gly  Asn Trp Leu Ala Tyr  Trp Gln Tyr 
    1610                 1615                 1620             


Glu Ile  Gly Val Ser Gln Gln  Asp Ala His Phe His  Phe His Gln 
    1625                 1630                 1635             


Ile Arg  Leu Gln Ser Phe Pro  Gly His Ser Gly Ala  Val Lys Cys 
    1640                 1645                 1650             


Val Ala  Pro Leu Ser Ser Glu  Asp Phe Phe Leu Ser  Gly Ser Lys 
    1655                 1660                 1665             


Asp Arg  Thr Val Arg Leu Trp  Pro Leu Tyr Asn Tyr  Gly Asp Gly 
    1670                 1675                 1680             


Thr Ser  Glu Thr Ala Pro Arg  Leu Val Tyr Thr Gln  His Arg Lys 
    1685                 1690                 1695             


Ser Val  Phe Phe Val Gly Gln  Leu Glu Ala Pro Gln  His Val Val 
    1700                 1705                 1710             


Ser Cys  Asp Gly Ala Val His  Val Trp Asp Pro Phe  Thr Gly Lys 
    1715                 1720                 1725             


Thr Leu  Arg Thr Val Glu Pro  Leu Asp Ser Arg Val  Pro Leu Thr 
    1730                 1735                 1740             


Ala Val  Ala Val Met Pro Ala  Pro His Thr Ser Ile  Thr Met Ala 
    1745                 1750                 1755             


Ser Ser  Asp Ser Thr Leu Arg  Phe Val Asp Cys Arg  Lys Pro Gly 
    1760                 1765                 1770             


Leu Gln  His Glu Phe Arg Leu  Gly Gly Gly Leu Asn  Pro Gly Leu 
    1775                 1780                 1785             


Val Arg  Ala Leu Ala Ile Ser  Pro Ser Gly Arg Ser  Val Val Ala 
    1790                 1795                 1800             


Gly Phe  Ser Ser Gly Phe Met  Val Leu Leu Asp Thr  Arg Thr Gly 
    1805                 1810                 1815             


Leu Val  Leu Arg Gly Trp Pro  Ala His Glu Gly Asp  Ile Leu Gln 
    1820                 1825                 1830             


Ile Lys  Ala Val Glu Gly Ser  Val Leu Val Ser Ser  Ser Ser Asp 
    1835                 1840                 1845             


His Ser  Leu Thr Val Trp Lys  Glu Leu Glu Gln Lys  Pro Thr His 
    1850                 1855                 1860             


His Tyr  Lys Ser Ala Ser Asp  Pro Ile His Thr Phe  Asp Leu Tyr 
    1865                 1870                 1875             


Gly Ser  Glu Val Val Thr Gly  Thr Val Ser Asn Lys  Ile Gly Val 
    1880                 1885                 1890             


Cys Ser  Leu Leu Glu Pro Pro  Ser Gln Ala Thr Thr  Lys Leu Ser 
    1895                 1900                 1905             


Ser Glu  Asn Phe Arg Gly Thr  Leu Thr Ser Leu Ala  Leu Leu Pro 
    1910                 1915                 1920             


Thr Lys  Arg His Leu Leu Leu  Gly Ser Asp Asn Gly  Val Ile Arg 
    1925                 1930                 1935             


Leu Leu  Ala 
    1940     


<210>  103
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Asn Thr Ala Asp Gln Ala Arg Val Gly Pro Ala Asp Asp Gly Pro 
1               5                   10                  15      


Ala Pro Ser Gly Glu Glu Glu Gly Glu Gly Gly Gly Glu Ala Gly Gly 
            20                  25                  30          


Lys Glu Pro Ala Ala Asp Ala Ala Pro Gly Pro Ser Ala Ala Phe Arg 
        35                  40                  45              


Leu Met Val Thr Arg Arg Glu Pro Ala Val Lys Leu Gln Tyr Ala Val 
    50                  55                  60                  


Ser Gly Leu Glu Pro Leu Ala Trp Ser Glu Asp His Arg Val Ser Val 
65                  70                  75                  80  


Ser Thr Ala Arg Ser Ile Ala Val Leu Glu Leu Ile Cys Asp Val His 
                85                  90                  95      


Asn Pro Gly Gln Asp Leu Val Ile His Arg Thr Ser Val Pro Ala Pro 
            100                 105                 110         


Leu Asn Ser Cys Leu Leu Lys Val Gly Ser Lys Thr Glu Val Ala Glu 
        115                 120                 125             


Cys Lys Glu Lys Phe Ala Ala Ser Lys Asp Pro Thr Val Ser Gln Thr 
    130                 135                 140                 


Phe Met Leu Asp Arg Val Phe Asn Pro Glu Gly Lys Ala Leu Pro Pro 
145                 150                 155                 160 


Met Arg Gly Phe Lys Tyr Thr Ser Trp Ser Pro Met Gly Cys Asp Ala 
                165                 170                 175     


Asn Gly Arg Cys Leu Leu Ala Ala Leu Thr Met Asp Asn Arg Leu Thr 
            180                 185                 190         


Ile Gln Ala Asn Leu Asn Arg Leu Gln Trp Val Gln Leu Val Asp Leu 
        195                 200                 205             


Thr Glu Ile Tyr Gly Glu Arg Leu Tyr Glu Thr Ser Tyr Arg Leu Ser 
    210                 215                 220                 


Lys Asn Glu Ala Pro Glu Gly Asn Leu Gly Asp Phe Ala Glu Phe Gln 
225                 230                 235                 240 


Arg Arg His Ser Met Gln Thr Pro Val Arg Met Glu Trp Ser Gly Ile 
                245                 250                 255     


Cys Thr Thr Gln Gln Val Lys His Asn Asn Glu Cys Arg Asp Val Gly 
            260                 265                 270         


Ser Val Leu Leu Ala Val Leu Phe Glu Asn Gly Asn Ile Ala Val Trp 
        275                 280                 285             


Gln Phe Gln Leu Pro Phe Val Gly Lys Glu Ser Ile Ser Ser Cys Asn 
    290                 295                 300                 


Thr Ile Glu Ser Gly Ile Thr Ser Pro Ser Val Leu Phe Trp Trp Glu 
305                 310                 315                 320 


Tyr Glu His Asn Asn Arg Lys Met Ser Gly Leu Ile Val Gly Ser Ala 
                325                 330                 335     


Phe Gly Pro Ile Lys Ile Leu Pro Val Asn Leu Lys Ala Val Lys Gly 
            340                 345                 350         


Tyr Phe Thr Leu Arg Gln Pro Val Ile Leu Trp Lys Glu Met Asp Gln 
        355                 360                 365             


Leu Pro Val His Ser Ile Lys Cys Val Pro Leu Tyr His Pro Tyr Gln 
    370                 375                 380                 


Lys Cys Ser Cys Ser Leu Val Val Ala Ala Arg Gly Ser Tyr Val Phe 
385                 390                 395                 400 


Trp Cys Leu Leu Leu Ile Ser Lys Ala Gly Leu Asn Val His Asn Ser 
                405                 410                 415     


His Val Thr Gly Leu His Ser Leu Pro Ile Val Ser Met Thr Ala Asp 
            420                 425                 430         


Lys Gln Asn Gly Thr Val Tyr Thr Cys Ser Ser Asp Gly Lys Val Arg 
        435                 440                 445             


Gln Leu Ile Pro Ile Phe Thr Asp Val Ala Leu Lys Phe Glu His Gln 
    450                 455                 460                 


Leu Ile Lys Leu Ser Asp Val Phe Gly Ser Val Arg Thr His Gly Ile 
465                 470                 475                 480 


Ala Val Ser Pro Cys Gly Ala Tyr Leu Ala Ile Ile Thr Thr Glu Gly 
                485                 490                 495     


Met Ile Asn Gly Leu His Pro Val Asn Lys Asn Tyr Gln Val Gln Phe 
            500                 505                 510         


Val Thr Leu Lys Thr Phe Glu Glu Ala Ala Ala Gln Leu Leu Glu Ser 
        515                 520                 525             


Ser Val Gln Asn Leu Phe Lys Gln Val Asp Leu Ile Asp Leu Val Arg 
    530                 535                 540                 


Trp Lys Ile Leu Lys Asp Lys His Ile Pro Gln Phe Leu Gln Glu Ala 
545                 550                 555                 560 


Leu Glu Lys Lys Ile Glu Ser Ser Gly Val Thr Tyr Phe Trp Arg Phe 
                565                 570                 575     


Lys Leu Phe Leu Leu Arg Ile Leu Tyr Gln Ser Met Gln Lys Thr Pro 
            580                 585                 590         


Ser Glu Ala Leu Trp Lys Pro Thr His Glu Asp Ser Lys Ile Leu Leu 
        595                 600                 605             


Val Asp Ser Pro Gly Met Gly Asn Ala Asp Asp Glu Gln Gln Glu Glu 
    610                 615                 620                 


Gly Thr Ser Ser Lys Gln Val Val Lys Gln Gly Leu Gln Glu Arg Ser 
625                 630                 635                 640 


Lys Glu Gly Asp Val Glu Glu Pro Thr Asp Asp Ser Leu Pro Thr Thr 
                645                 650                 655     


Gly Asp Ala Gly Gly Arg Glu Pro Met Glu Glu Lys Leu Leu Glu Ile 
            660                 665                 670         


Gln Gly Lys Ile Glu Ala Val Glu Met His Leu Thr Arg Glu His Met 
        675                 680                 685             


Lys Arg Val Leu Gly Glu Val Tyr Leu His Thr Trp Ile Thr Glu Asn 
    690                 695                 700                 


Thr Ser Ile Pro Thr Arg Gly Leu Cys Asn Phe Leu Met Ser Asp Glu 
705                 710                 715                 720 


Glu Tyr Asp Asp Arg Thr Ala Arg Val Leu Ile Gly His Ile Ser Lys 
                725                 730                 735     


Lys Met Asn Lys Gln Thr Phe Pro Glu His Cys Ser Leu Cys Lys Glu 
            740                 745                 750         


Ile Leu Pro Phe Thr Asp Arg Lys Gln Ala Val Cys Ser Asn Gly His 
        755                 760                 765             


Ile Trp Leu Arg Cys Phe Leu Thr Tyr Gln Ser Cys Gln Ser Leu Ile 
    770                 775                 780                 


Tyr Arg Arg Cys Leu Leu His Asp Ser Ile Ala Arg His Pro Ala Pro 
785                 790                 795                 800 


Glu Asp Pro Asp Trp Ile Lys Arg Leu Leu Gln Ser Pro Cys Pro Phe 
                805                 810                 815     


Cys Asp Ser Pro Val Phe 
            820         


<210>  104
<211>  689
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ala Ala Ala Thr Ala Ser Pro Arg Ser Leu Leu Val Leu Leu Gln 
1               5                   10                  15      


Val Val Val Leu Ala Leu Ala Gln Ile Arg Gly Pro Pro Gly Glu Arg 
            20                  25                  30          


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ser Asp Gly 
        35                  40                  45              


Ile Asp Gly Asp Asn Gly Pro Pro Gly Lys Ala Gly Pro Pro Gly Pro 
    50                  55                  60                  


Lys Gly Glu Pro Gly Lys Ala Gly Pro Asp Gly Pro Asp Gly Lys Pro 
65                  70                  75                  80  


Gly Ile Asp Gly Leu Thr Gly Ala Lys Gly Glu Pro Gly Pro Met Gly 
                85                  90                  95      


Ile Pro Gly Val Lys Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Leu 
            100                 105                 110         


Pro Gly Pro Gly Phe Ala Gly Pro Pro Gly Pro Pro Gly Pro Val Gly 
        115                 120                 125             


Leu Pro Gly Glu Ile Gly Ile Arg Gly Pro Lys Gly Asp Pro Gly Pro 
    130                 135                 140                 


Asp Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Arg Pro 
145                 150                 155                 160 


Gly Thr Ile Gln Gly Leu Glu Gly Ser Ala Asp Phe Leu Cys Pro Thr 
                165                 170                 175     


Asn Cys Pro Pro Gly Met Lys Gly Pro Pro Gly Leu Gln Gly Val Lys 
            180                 185                 190         


Gly His Ala Gly Lys Arg Gly Ile Leu Gly Asp Pro Gly His Gln Gly 
        195                 200                 205             


Lys Pro Gly Pro Lys Gly Asp Val Gly Ala Ser Gly Glu Gln Gly Ile 
    210                 215                 220                 


Pro Gly Pro Pro Gly Pro Gln Gly Ile Arg Gly Tyr Pro Gly Met Ala 
225                 230                 235                 240 


Gly Pro Lys Gly Glu Thr Gly Pro His Gly Tyr Lys Gly Met Val Gly 
                245                 250                 255     


Ala Ile Gly Ala Thr Gly Pro Pro Gly Glu Glu Gly Pro Arg Gly Pro 
            260                 265                 270         


Pro Gly Arg Ala Gly Glu Lys Gly Asp Glu Gly Ser Pro Gly Ile Arg 
        275                 280                 285             


Gly Pro Gln Gly Ile Thr Gly Pro Lys Gly Ala Thr Gly Pro Pro Gly 
    290                 295                 300                 


Ile Asn Gly Lys Asp Gly Thr Pro Gly Thr Pro Gly Met Lys Gly Ser 
305                 310                 315                 320 


Ala Gly Gln Ala Gly Gln Pro Gly Ser Pro Gly His Gln Gly Leu Ala 
                325                 330                 335     


Gly Val Pro Gly Gln Pro Gly Thr Lys Gly Gly Pro Gly Asp Gln Gly 
            340                 345                 350         


Glu Pro Gly Pro Gln Gly Leu Pro Gly Phe Ser Gly Pro Pro Gly Lys 
        355                 360                 365             


Glu Gly Glu Pro Gly Pro Arg Gly Glu Ile Gly Pro Gln Gly Ile Met 
    370                 375                 380                 


Gly Gln Lys Gly Asp Gln Gly Glu Arg Gly Pro Val Gly Gln Pro Gly 
385                 390                 395                 400 


Pro Gln Gly Arg Gln Gly Pro Lys Gly Glu Gln Gly Pro Pro Gly Ile 
                405                 410                 415     


Pro Gly Pro Gln Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Ser Pro 
            420                 425                 430         


Gly Lys Thr Gly Pro Arg Gly Lys Val Gly Asp Pro Gly Val Ala Gly 
        435                 440                 445             


Leu Pro Gly Glu Lys Gly Glu Lys Gly Glu Ser Gly Glu Pro Gly Pro 
    450                 455                 460                 


Lys Gly Gln Gln Gly Val Arg Gly Glu Pro Gly Tyr Pro Gly Pro Ser 
465                 470                 475                 480 


Gly Asp Ala Gly Ala Pro Gly Val Gln Gly Tyr Pro Gly Pro Pro Gly 
                485                 490                 495     


Pro Arg Gly Leu Ala Gly Asn Arg Gly Val Pro Gly Gln Pro Gly Arg 
            500                 505                 510         


Gln Gly Val Glu Gly Arg Asp Ala Thr Asp Gln His Ile Val Asp Val 
        515                 520                 525             


Ala Leu Lys Met Leu Gln Glu Gln Leu Ala Glu Val Ala Val Ser Ala 
    530                 535                 540                 


Lys Arg Glu Ala Leu Gly Ala Val Gly Met Met Gly Pro Pro Gly Pro 
545                 550                 555                 560 


Pro Gly Pro Pro Gly Tyr Pro Gly Lys Gln Gly Pro His Gly His Pro 
                565                 570                 575     


Gly Pro Arg Gly Val Pro Gly Ile Val Gly Ala Val Gly Gln Ile Gly 
            580                 585                 590         


Asn Thr Gly Pro Lys Gly Lys Arg Gly Glu Lys Gly Asp Pro Gly Glu 
        595                 600                 605             


Val Gly Arg Gly His Pro Gly Met Pro Gly Pro Pro Gly Ile Pro Gly 
    610                 615                 620                 


Leu Pro Gly Arg Pro Gly Gln Ala Ile Asn Gly Lys Asp Gly Asp Arg 
625                 630                 635                 640 


Gly Ser Pro Gly Ala Pro Gly Glu Ala Gly Arg Pro Gly Leu Pro Gly 
                645                 650                 655     


Pro Val Gly Leu Pro Gly Phe Cys Glu Pro Ala Ala Cys Leu Gly Ala 
            660                 665                 670         


Ser Ala Tyr Ala Ser Ala Arg Leu Thr Glu Pro Gly Ser Ile Lys Gly 
        675                 680                 685             


Pro 
    


<210>  105
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Thr Gly Thr Glu Leu Val Leu Leu Thr 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Thr Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Thr Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Thr Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp Glu Pro Thr Glu 
            100                 105                 110         


Thr Glu Thr Ser Gly Glu Gln Leu Gly Ile Ser Asp Asn Gly Gly Leu 
        115                 120                 125             


Phe Val Met Asp Glu Asp Ala Thr Leu Gln Asp Leu Pro Pro Phe Cys 
    130                 135                 140                 


Glu Ser Asp Pro Glu Ser Thr Asp Asp Gly Ser Leu Ser Glu Glu Thr 
145                 150                 155                 160 


Pro Ala Gly Pro Pro Thr Cys Ser Val Pro Pro Ala Ser Ala Leu Pro 
                165                 170                 175     


Thr Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val Pro Val Trp Gly 
            180                 185                 190         


Phe Lys Glu Lys Arg Thr Glu Ala Arg Ser Ser Asp Glu Glu Asn Gly 
        195                 200                 205             


Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala Ser Met Arg Ala 
    210                 215                 220                 


Leu Val Leu Arg Glu Ala Glu Asp Thr Gln Val Phe Gly Asp Leu Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Asn Thr Ser Asp Phe Gln Lys Leu Lys Arg Lys Tyr 
                245                 250                 255     


<210>  106
<211>  1231
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  107
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Arg Pro Glu Pro Gly Gly Cys Cys Cys Arg Arg Thr Val Arg Ala 
1               5                   10                  15      


Asn Gly Cys Val Ala Asn Gly Glu Val Arg Asn Gly Tyr Val Arg Ser 
            20                  25                  30          


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Ile His His Val 
        35                  40                  45              


Thr Gln Asn Gly Gly Leu Tyr Lys Arg Pro Phe Asn Glu Ala Phe Glu 
    50                  55                  60                  


Glu Thr Pro Met Leu Val Ala Val Leu Thr Tyr Val Gly Tyr Gly Val 
65                  70                  75                  80  


Leu Thr Leu Phe Gly Tyr Leu Arg Asp Phe Leu Arg Tyr Trp Arg Ile 
                85                  90                  95      


Glu Lys Cys His His Ala Thr Glu Arg Glu Glu Gln Lys Asp Phe Val 
            100                 105                 110         


Ser Leu Tyr Gln Asp Phe Glu Asn Phe Tyr Thr Arg Asn Leu Tyr Met 
        115                 120                 125             


Arg Ile Arg Asp Asn Trp Asn Arg Pro Ile Cys Ser Val Pro Gly Ala 
    130                 135                 140                 


Arg Val Asp Ile Met Glu Arg Gln Ser His Asp Tyr Asn Trp Ser Phe 
145                 150                 155                 160 


Lys Tyr Thr Gly Asn Ile Ile Lys Gly Val Ile Asn Met Gly Ser Tyr 
                165                 170                 175     


Asn Tyr Leu Gly Phe Ala Arg Asn Thr Gly Ser Cys Gln Glu Ala Ala 
            180                 185                 190         


Ala Lys Val Leu Glu Glu Tyr Gly Ala Gly Val Cys Ser Thr Arg Gln 
        195                 200                 205             


Glu Ile Gly Asn Leu Asp Lys His Glu Glu Leu Glu Glu Leu Val Ala 
    210                 215                 220                 


Arg Phe Leu Gly Val Glu Ala Ala Met Ala Tyr Gly Met Gly Phe Ala 
225                 230                 235                 240 


Thr Asn Ser Met Asn Ile Pro Ala Leu Val Gly Lys Gly Cys Leu Ile 
                245                 250                 255     


Leu Ser Asp Glu Leu Asn His Ala Ser Leu Val Leu Gly Ala Arg Leu 
            260                 265                 270         


Ser Gly Ala Thr Ile Arg Ile Phe Lys His Asn Asn Met Gln Ser Leu 
        275                 280                 285             


Glu Lys Leu Leu Lys Asp Ala Ile Val Tyr Gly Gln Pro Arg Thr Arg 
    290                 295                 300                 


Arg Pro Trp Lys Lys Ile Leu Ile Leu Val Glu Gly Ile Tyr Ser Met 
305                 310                 315                 320 


Glu Gly Ser Ile Val Arg Leu Pro Glu Val Ile Ala Leu Lys Lys Lys 
                325                 330                 335     


Tyr Lys Ala Tyr Leu Tyr Leu Asp Glu Ala His Ser Ile Gly Ala Leu 
            340                 345                 350         


Gly Pro Thr Gly Arg Gly Val Val Glu Tyr Phe Gly Leu Asp Pro Glu 
        355                 360                 365             


Asp Val Asp Val Met Met Gly Thr Phe Thr Lys Ser Phe Gly Ala Ser 
    370                 375                 380                 


Gly Gly Tyr Ile Gly Gly Lys Lys Glu Leu Ile Asp Tyr Leu Arg Thr 
385                 390                 395                 400 


His Ser His Ser Ala Val Tyr Ala Thr Ser Leu Ser Pro Pro Val Val 
                405                 410                 415     


Glu Gln Ile Ile Thr Ser Met Lys Cys Ile Met Gly Gln Asp Gly Thr 
            420                 425                 430         


Ser Leu Gly Lys Glu Cys Val Gln Gln Leu Ala Glu Asn Thr Arg Tyr 
        435                 440                 445             


Phe Arg Arg Arg Leu Lys Glu Met Gly Phe Ile Ile Tyr Gly Asn Glu 
    450                 455                 460                 


Asp Ser Pro Val Val Pro Leu Met Leu Tyr Met Pro Ala Lys Ile Gly 
465                 470                 475                 480 


Ala Phe Gly Arg Glu Met Leu Lys Arg Asn Ile Gly Val Val Val Val 
                485                 490                 495     


Gly Phe Pro Ala Thr Pro Ile Ile Glu Ser Arg Ala Arg Phe Cys Leu 
            500                 505                 510         


Ser Ala Ala His Thr Lys Glu Ile Leu Asp Thr Ala Leu Lys Glu Ile 
        515                 520                 525             


Asp Glu Val Gly Asp Leu Leu Gln Leu Lys Tyr Ser Arg His Arg Leu 
    530                 535                 540                 


Val Pro Leu Leu Asp Arg Pro Phe Asp Glu Thr Thr Tyr Glu Glu Thr 
545                 550                 555                 560 


Glu Asp 
        


<210>  108
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Leu Phe Val Arg Leu Leu Ala Leu Ala Leu Ala Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ala Ala Thr Leu Ala Gly Pro Ala Lys Ser Pro Tyr Gln Leu 
            20                  25                  30          


Val Leu Gln His Ser Arg Leu Arg Gly Arg Gln His Gly Pro Asn Val 
        35                  40                  45              


Cys Ala Val Gln Lys Val Ile Gly Thr Asn Arg Lys Tyr Phe Thr Asn 
    50                  55                  60                  


Cys Lys Gln Trp Tyr Gln Arg Lys Ile Cys Gly Lys Ser Thr Val Ile 
65                  70                  75                  80  


Ser Tyr Glu Cys Cys Pro Gly Tyr Glu Lys Val Pro Gly Glu Lys Gly 
                85                  90                  95      


Cys Pro Ala Ala Leu Pro Leu Ser Asn Leu Tyr Glu Thr Leu Gly Val 
            100                 105                 110         


Val Gly Ser Thr Thr Thr Gln Leu Tyr Thr Asp Arg Thr Glu Lys Leu 
        115                 120                 125             


Arg Pro Glu Met Glu Gly Pro Gly Ser Phe Thr Ile Phe Ala Pro Ser 
    130                 135                 140                 


Asn Glu Ala Trp Ala Ser Leu Pro Ala Glu Val Leu Asp Ser Leu Val 
145                 150                 155                 160 


Ser Asn Val Asn Ile Glu Leu Leu Asn Ala Leu Arg Tyr His Met Val 
                165                 170                 175     


Gly Arg Arg Val Leu Thr Asp Glu Leu Lys His Gly Met Thr Leu Thr 
            180                 185                 190         


Ser Met Tyr Gln Asn Ser Asn Ile Gln Ile His His Tyr Pro Asn Gly 
        195                 200                 205             


Ile Val Thr Val Asn Cys Ala Arg Leu Leu Lys Ala Asp His His Ala 
    210                 215                 220                 


Thr Asn Gly Val Val His Leu Ile Asp Lys Val Ile Ser Thr Ile Thr 
225                 230                 235                 240 


Asn Asn Ile Gln Gln Ile Ile Glu Ile Glu Asp Thr Phe Glu Thr Leu 
                245                 250                 255     


Arg Ala Ala Val Ala Ala Ser Gly Leu Asn Thr Met Leu Glu Gly Asn 
            260                 265                 270         


Gly Gln Tyr Thr Leu Leu Ala Pro Thr Asn Glu Ala Phe Glu Lys Ile 
        275                 280                 285             


Pro Ser Glu Thr Leu Asn Arg Ile Leu Gly Asp Pro Glu Ala Leu Arg 
    290                 295                 300                 


Asp Leu Leu Asn Asn His Ile Leu Lys Ser Ala Met Cys Ala Glu Ala 
305                 310                 315                 320 


Ile Val Ala Gly Leu Ser Val Glu Thr Leu Glu Gly Thr Thr Leu Glu 
                325                 330                 335     


Val Gly Cys Ser Gly Asp Met Leu Thr Ile Asn Gly Lys Ala Ile Ile 
            340                 345                 350         


Ser Asn Lys Asp Ile Leu Ala Thr Asn Gly Val Ile His Tyr Ile Asp 
        355                 360                 365             


Glu Leu Leu Ile Pro Asp Ser Ala Lys Thr Leu Phe Glu Leu Ala Ala 
    370                 375                 380                 


Glu Ser Asp Val Ser Thr Ala Ile Asp Leu Phe Arg Gln Ala Gly Leu 
385                 390                 395                 400 


Gly Asn His Leu Ser Gly Ser Glu Arg Leu Thr Leu Leu Ala Pro Leu 
                405                 410                 415     


Asn Ser Val Phe Lys Asp Gly Thr Pro Pro Ile Asp Ala His Thr Arg 
            420                 425                 430         


Asn Leu Leu Arg Asn His Ile Ile Lys Asp Gln Leu Ala Ser Lys Tyr 
        435                 440                 445             


Leu Tyr His Gly Gln Thr Leu Glu Thr Leu Gly Gly Lys Lys Leu Arg 
    450                 455                 460                 


Val Phe Val Tyr Arg Asn Ser Leu Cys Ile Glu Asn Ser Cys Ile Ala 
465                 470                 475                 480 


Ala His Asp Lys Arg Gly Arg Tyr Gly Thr Leu Phe Thr Met Asp Arg 
                485                 490                 495     


Val Leu Thr Pro Pro Met Gly Thr Val Met Asp Val Leu Lys Gly Asp 
            500                 505                 510         


Asn Arg Phe Ser Met Leu Val Ala Ala Ile Gln Ser Ala Gly Leu Thr 
        515                 520                 525             


Glu Thr Leu Asn Arg Glu Gly Val Tyr Thr Val Phe Ala Pro Thr Asn 
    530                 535                 540                 


Glu Ala Phe Arg Ala Leu Pro Pro Arg Glu Arg Ser Arg Leu Leu Gly 
545                 550                 555                 560 


Asp Ala Lys Glu Leu Ala Asn Ile Leu Lys Tyr His Ile Gly Asp Glu 
                565                 570                 575     


Ile Leu Val Ser Gly Gly Ile Gly Ala Leu Val Arg Leu Lys Ser Leu 
            580                 585                 590         


Gln Gly Asp Lys Leu Glu Val Ser Leu Lys Asn Asn Val Val Ser Val 
        595                 600                 605             


Asn Lys Glu Pro Val Ala Glu Pro Asp Ile Met Ala Thr Asn Gly Val 
    610                 615                 620                 


Val His Val Ile Thr Asn Val Leu Gln Pro Pro Ala Asn Arg Pro Gln 
625                 630                 635                 640 


Glu Arg Gly Asp Glu Leu Ala Asp Ser Ala Leu Glu Ile Phe Lys Gln 
                645                 650                 655     


Ala Ser Ala Phe Ser Arg Ala Ser Gln Arg Ser Val Arg Leu Ala Pro 
            660                 665                 670         


Val Tyr Gln Lys Leu Leu Glu Arg Met Lys His 
        675                 680             


<210>  109
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Lys Arg Ile Phe Ser Leu Leu Glu Lys Thr Trp Leu Gly Ala Pro 
1               5                   10                  15      


Ile Gln Phe Ala Trp Gln Lys Thr Ser Gly Asn Tyr Leu Ala Val Thr 
            20                  25                  30          


Gly Ala Asp Tyr Ile Val Lys Ile Phe Asp Arg His Gly Gln Lys Arg 
        35                  40                  45              


Ser Glu Ile Asn Leu Pro Gly Asn Cys Val Ala Met Asp Trp Asp Lys 
    50                  55                  60                  


Asp Gly Asp Val Leu Ala Val Ile Ala Glu Lys Ser Ser Cys Ile Tyr 
65                  70                  75                  80  


Leu Trp Asp Ala Asn Thr Asn Lys Thr Ser Gln Leu Asp Asn Gly Met 
                85                  90                  95      


Arg Asp Gln Met Ser Phe Leu Leu Trp Ser Lys Val Gly Ser Phe Leu 
            100                 105                 110         


Ala Val Gly Thr Val Lys Gly Asn Leu Leu Ile Tyr Asn His Gln Thr 
        115                 120                 125             


Ser Arg Lys Ile Pro Val Leu Gly Lys His Thr Lys Arg Ile Thr Cys 
    130                 135                 140                 


Gly Cys Trp Asn Ala Glu Asn Leu Leu Ala Leu Gly Gly Glu Asp Lys 
145                 150                 155                 160 


Met Ile Thr Val Ser Asn Gln Glu Gly Asp Thr Ile Arg Gln Thr Gln 
                165                 170                 175     


Val Arg Ser Glu Pro Ser Asn Met Gln Phe Phe Leu Met Lys Met Asp 
            180                 185                 190         


Asp Arg Thr Ser Ala Ala Glu Ser Met Ile Ser Val Val Leu Gly Lys 
        195                 200                 205             


Lys Thr Leu Phe Phe Leu Asn Leu Asn Glu Pro Asp Asn Pro Ala Asp 
    210                 215                 220                 


Leu Glu Phe Gln Gln Asp Phe Gly Asn Ile Val Cys Tyr Asn Trp Tyr 
225                 230                 235                 240 


Gly Asp Gly Arg Ile Met Ile Gly Phe Ser Cys Gly His Phe Val Val 
                245                 250                 255     


Ile Ser Thr His Thr Gly Glu Leu Gly Gln Glu Ile Phe Gln Ala Arg 
            260                 265                 270         


Asn His Lys Asp Asn Leu Thr Ser Ile Ala Val Ser Gln Thr Leu Asn 
        275                 280                 285             


Lys Val Ala Thr Cys Gly Asp Asn Cys Ile Lys Ile Gln Asp Leu Val 
    290                 295                 300                 


Asp Leu Lys Asp Met Tyr Val Ile Leu Asn Leu Asp Glu Glu Asn Lys 
305                 310                 315                 320 


Gly Leu Gly Thr Leu Ser Trp Thr Asp Asp Gly Gln Leu Leu Ala Leu 
                325                 330                 335     


Ser Thr Gln Arg Gly Ser Leu His Val Phe Leu Thr Lys Leu Pro Ile 
            340                 345                 350         


Leu Gly Asp Ala Cys Ser Thr Arg Ile Ala Tyr Leu Thr Ser Leu Leu 
        355                 360                 365             


Glu Val Thr Val Ala Asn Pro Val Glu Gly Glu Leu Pro Ile Thr Val 
    370                 375                 380                 


Ser Val Asp Val Glu Pro Asn Phe Val Ala Val Gly Leu Tyr His Leu 
385                 390                 395                 400 


Ala Val Gly Met Asn Asn Arg Ala Trp Phe Tyr Val Leu Gly Glu Asn 
                405                 410                 415     


Ala Val Lys Lys Leu Lys Asp Met Glu Tyr Leu Gly Thr Val Ala Ser 
            420                 425                 430         


Ile Cys Leu His Ser Asp Tyr Ala Ala Ala Leu Phe Glu Gly Lys Val 
        435                 440                 445             


Gln Leu His Leu Ile Glu Ser Glu Ile Leu Asp Ala Gln Glu Glu Arg 
    450                 455                 460                 


Glu Thr Arg Leu Phe Pro Ala Val Asp Asp Lys Cys Arg Ile Leu Cys 
465                 470                 475                 480 


His Ala Leu Thr Ser Asp Phe Leu Ile Tyr Gly Thr Asp Thr Gly Val 
                485                 490                 495     


Val Gln Tyr Phe Tyr Ile Glu Asp Trp Gln Phe Val Asn Asp Tyr Arg 
            500                 505                 510         


His Pro Val Ser Val Lys Lys Ile Phe Pro Asp Pro Asn Gly Thr Arg 
        515                 520                 525             


Leu Val Phe Ile Asp Glu Lys Ser Asp Gly Phe Val Tyr Cys Pro Val 
    530                 535                 540                 


Asn Asp Ala Thr Tyr Glu Ile Pro Asp Phe Ser Pro Thr Ile Lys Gly 
545                 550                 555                 560 


Val Leu Trp Glu Asn Trp Pro Met Asp Lys Gly Val Phe Ile Ala Tyr 
                565                 570                 575     


Asp Asp Asp Lys Val Tyr Thr Tyr Val Phe His Lys Asp Thr Ile Gln 
            580                 585                 590         


Gly Ala Lys Val Ile Leu Ala Gly Ser Thr Lys Val Pro Phe Ala His 
        595                 600                 605             


Lys Pro Leu Leu Leu Tyr Asn Gly Glu Leu Thr Cys Gln Thr Gln Ser 
    610                 615                 620                 


Gly Lys Val Asn Asn Ile Tyr Leu Ser Thr His Gly Phe Leu Ser Asn 
625                 630                 635                 640 


Leu Lys Asp Thr Gly Pro Asp Glu Leu Arg Pro Met Leu Ala Gln Asn 
                645                 650                 655     


Leu Met Leu Lys Arg Phe Ser Asp Ala Trp Glu Met Cys Arg Ile Leu 
            660                 665                 670         


Asn Asp Glu Ala Ala Trp Asn Glu Leu Ala Arg Ala Cys Leu His His 
        675                 680                 685             


Met Glu Val Glu Phe Ala Ile Arg Val Tyr Arg Arg Ile Gly Asn Val 
    690                 695                 700                 


Gly Ile Val Met Ser Leu Glu Gln Ile Lys Gly Ile Glu Asp Tyr Asn 
705                 710                 715                 720 


Leu Leu Ala Gly His Leu Ala Met Phe Thr Asn Asp Tyr Asn Leu Ala 
                725                 730                 735     


Gln Asp Leu Tyr Leu Ala Ser Ser Cys Pro Ile Ala Ala Leu Glu Met 
            740                 745                 750         


Arg Arg Asp Leu Gln His Trp Asp Ser Ala Leu Gln Leu Ala Lys His 
        755                 760                 765             


Leu Ala Pro Asp Gln Ile Pro Phe Ile Ser Lys Glu Tyr Ala Ile Gln 
    770                 775                 780                 


Leu Glu Phe Ala Gly Asp Tyr Val Asn Ala Leu Ala His Tyr Glu Lys 
785                 790                 795                 800 


Gly Ile Thr Gly Asp Asn Lys Glu His Asp Glu Ala Cys Leu Ala Gly 
                805                 810                 815     


Val Ala Gln Met Ser Ile Arg Met Gly Asp Ile Arg Arg Gly Val Asn 
            820                 825                 830         


Gln Ala Leu Lys His Pro Ser Arg Val Leu Lys Arg Asp Cys Gly Ala 
        835                 840                 845             


Ile Leu Glu Asn Met Lys Gln Phe Ser Glu Ala Ala Gln Leu Tyr Glu 
    850                 855                 860                 


Lys Gly Leu Tyr Tyr Asp Lys Ala Ala Ser Val Tyr Ile Arg Ser Lys 
865                 870                 875                 880 


Asn Trp Ala Lys Val Gly Asp Leu Leu Pro His Val Ser Ser Pro Lys 
                885                 890                 895     


Ile His Leu Gln Tyr Ala Lys Ala Lys Glu Ala Asp Gly Arg Tyr Lys 
            900                 905                 910         


Glu Ala Val Val Ala Tyr Glu Asn Ala Lys Gln Trp Gln Ser Val Ile 
        915                 920                 925             


Arg Ile Tyr Leu Asp His Leu Asn Asn Pro Glu Lys Ala Val Asn Ile 
    930                 935                 940                 


Val Arg Glu Thr Gln Ser Leu Asp Gly Ala Lys Met Val Ala Arg Phe 
945                 950                 955                 960 


Phe Leu Gln Leu Gly Asp Tyr Gly Ser Ala Ile Gln Phe Leu Val Met 
                965                 970                 975     


Ser Lys Cys Asn Asn Glu Ala Phe Thr Leu Ala Gln Gln His Asn Lys 
            980                 985                 990         


Met Glu Ile Tyr Ala Asp Ile Ile  Gly Ser Glu Asp Thr  Thr Asn Glu 
        995                 1000                 1005             


Asp Tyr  Gln Ser Ile Ala Leu  Tyr Phe Glu Gly Glu  Lys Arg Tyr 
    1010                 1015                 1020             


Leu Gln  Ala Gly Lys Phe Phe  Leu Leu Cys Gly Gln  Tyr Ser Arg 
    1025                 1030                 1035             


Ala Leu  Lys His Phe Leu Lys  Cys Pro Ser Ser Glu  Asp Asn Val 
    1040                 1045                 1050             


Ala Ile  Glu Met Ala Ile Glu  Thr Val Gly Gln Ala  Lys Asp Glu 
    1055                 1060                 1065             


Leu Leu  Thr Asn Gln Leu Ile  Asp His Leu Leu Gly  Glu Asn Asp 
    1070                 1075                 1080             


Gly Met  Pro Lys Asp Ala Lys  Tyr Leu Phe Arg Leu  Tyr Met Ala 
    1085                 1090                 1095             


Leu Lys  Gln Tyr Arg Glu Ala  Ala Gln Thr Ala Ile  Ile Ile Ala 
    1100                 1105                 1110             


Arg Glu  Glu Gln Ser Ala Gly  Asn Tyr Arg Asn Ala  His Asp Val 
    1115                 1120                 1125             


Leu Phe  Ser Met Tyr Ala Glu  Leu Lys Ser Gln Lys  Ile Lys Ile 
    1130                 1135                 1140             


Pro Ser  Glu Met Ala Thr Asn  Leu Met Ile Leu His  Ser Tyr Ile 
    1145                 1150                 1155             


Leu Val  Lys Ile His Val Lys  Asn Gly Asp His Met  Lys Gly Ala 
    1160                 1165                 1170             


Arg Met  Leu Ile Arg Val Ala  Asn Asn Ile Ser Lys  Phe Pro Ser 
    1175                 1180                 1185             


His Ile  Val Pro Ile Leu Thr  Ser Thr Val Ile Glu  Cys His Arg 
    1190                 1195                 1200             


Ala Gly  Leu Lys Asn Ser Ala  Phe Ser Phe Ala Ala  Met Leu Met 
    1205                 1210                 1215             


Arg Pro  Glu Tyr Arg Ser Lys  Ile Asp Ala Lys Tyr  Lys Lys Lys 
    1220                 1225                 1230             


Ile Glu  Gly Met Val Arg Arg  Pro Asp Ile Ser Glu  Ile Glu Glu 
    1235                 1240                 1245             


Ala Thr  Thr Pro Cys Pro Phe  Cys Lys Phe Leu Leu  Pro Glu Cys 
    1250                 1255                 1260             


Glu Leu  Leu Cys Pro Gly Cys  Lys Asn Ser Ile Pro  Tyr Cys Ile 
    1265                 1270                 1275             


Ala Thr  Gly Arg His Met Leu  Lys Asp Asp Trp Thr  Val Cys Pro 
    1280                 1285                 1290             


His Cys  Asp Phe Pro Ala Leu  Tyr Ser Glu Leu Lys  Ile Met Leu 
    1295                 1300                 1305             


Asn Thr  Glu Ser Thr Cys Pro  Met Cys Ser Glu Arg  Leu Asn Ala 
    1310                 1315                 1320             


Ala Gln  Leu Lys Lys Ile Ser  Asp Cys Thr Gln Tyr  Leu Arg Thr 
    1325                 1330                 1335             


Glu Glu  Glu Leu 
    1340         


<210>  110
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ser Arg Cys Ala Gln Ala Ala Glu Val Ala Ala Thr Val Pro Gly 
1               5                   10                  15      


Ala Gly Val Gly Asn Val Gly Leu Arg Pro Pro Met Val Pro Arg Gln 
            20                  25                  30          


Ala Ser Phe Phe Pro Pro Pro Val Pro Asn Pro Phe Val Gln Gln Thr 
        35                  40                  45              


Gln Ile Gly Ser Ala Arg Arg Val Gln Ile Val Leu Leu Gly Ile Ile 
    50                  55                  60                  


Leu Leu Pro Ile Arg Val Leu Leu Val Ala Leu Ile Leu Leu Leu Ala 
65                  70                  75                  80  


Trp Pro Phe Ala Ala Ile Ser Thr Val Cys Cys Pro Glu Lys Leu Thr 
                85                  90                  95      


His Pro Ile Thr Gly Trp Arg Arg Lys Ile Thr Gln Thr Ala Leu Lys 
            100                 105                 110         


Phe Leu Gly Arg Ala Met Phe Phe Ser Met Gly Phe Ile Val Ala Val 
        115                 120                 125             


Lys Gly Lys Ile Ala Ser Pro Leu Glu Ala Pro Val Phe Val Ala Ala 
    130                 135                 140                 


Pro His Ser Thr Phe Phe Asp Gly Ile Ala Cys Val Val Ala Gly Leu 
145                 150                 155                 160 


Pro Ser Met Val Ser Arg Asn Glu Asn Ala Gln Val Pro Leu Ile Gly 
                165                 170                 175     


Arg Leu Leu Arg Ala Val Gln Pro Val Leu Val Ser Arg Val Asp Pro 
            180                 185                 190         


Asp Ser Arg Lys Asn Thr Ile Asn Glu Ile Ile Lys Arg Thr Thr Ser 
        195                 200                 205             


Gly Gly Glu Trp Pro Gln Ile Leu Val Phe Pro Glu Gly Thr Cys Thr 
    210                 215                 220                 


Asn Arg Ser Cys Leu Ile Thr Phe Lys Pro Gly Ala Phe Ile Pro Gly 
225                 230                 235                 240 


Val Pro Val Gln Pro Val Leu Leu Arg Tyr Pro Asn Lys Leu Asp Thr 
                245                 250                 255     


Val Thr Trp Thr Trp Gln Gly Tyr Thr Phe Ile Gln Leu Cys Met Leu 
            260                 265                 270         


Thr Phe Cys Gln Leu Phe Thr Lys Val Glu Val Glu Phe Met Pro Val 
        275                 280                 285             


Gln Val Pro Asn Asp Glu Glu Lys Asn Asp Pro Val Leu Phe Ala Asn 
    290                 295                 300                 


Lys Val Arg Asn Leu Met Ala Glu Ala Leu Gly Ile Pro Val Thr Asp 
305                 310                 315                 320 


His Thr Tyr Glu Asp Cys Arg Leu Met Ile Ser Ala Gly Gln Leu Thr 
                325                 330                 335     


Leu Pro Met Glu Ala Gly Leu Val Glu Phe Thr Lys Ile Ser Arg Lys 
            340                 345                 350         


Leu Lys Leu Asp Trp Asp Gly Val Arg Lys His Leu Asp Glu Tyr Ala 
        355                 360                 365             


Ser Ile Ala Ser Ser Ser Lys Gly Gly Arg Ile Gly Ile Glu Glu Phe 
    370                 375                 380                 


Ala Lys Tyr Leu Lys Leu Pro Val Ser Asp Val Leu Arg Gln Leu Phe 
385                 390                 395                 400 


Ala Leu Phe Asp Arg Asn His Asp Gly Ser Ile Asp Phe Arg Glu Tyr 
                405                 410                 415     


Val Ile Gly Leu Ala Val Leu Cys Asn Pro Ser Asn Thr Glu Glu Ile 
            420                 425                 430         


Ile Gln Val Ala Phe Lys Leu Phe Asp Val Asp Glu Asp Gly Tyr Ile 
        435                 440                 445             


Thr Glu Glu Glu Phe Ser Thr Ile Leu Gln Ala Ser Leu Gly Val Pro 
    450                 455                 460                 


Asp Leu Asp Val Ser Gly Leu Phe Lys Glu Ile Ala Gln Gly Asp Ser 
465                 470                 475                 480 


Ile Ser Tyr Glu Glu Phe Lys Ser Phe Ala Leu Lys His Pro Glu Tyr 
                485                 490                 495     


Ala Lys Ile Phe Thr Thr Tyr Leu Asp Leu Gln Thr Cys His Val Phe 
            500                 505                 510         


Ser Leu Pro Lys Glu Val Gln Thr Thr Pro Ser Thr Ala Ser Asn Lys 
        515                 520                 525             


Val Ser Pro Glu Lys His Glu Glu Ser Thr Ser Asp Lys Lys Asp Asp 
    530                 535                 540                 


<210>  111
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu 
        35                  40                  45              


Ser Gly Leu Ser Phe Ile Thr Phe Ile Cys Tyr Val Ala Ser Ser Ala 
    50                  55                  60                  


Ser Ala Phe Leu Thr Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr 
65                  70                  75                  80  


Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu 
                85                  90                  95      


Cys Trp Pro Met Met Asp Phe Leu Arg Cys Val Thr Ala Ala Leu Ile 
            100                 105                 110         


Tyr Phe Ala Ile Ser Ile Thr Ala Ile Ala Lys Tyr Ser Asp Gly Ala 
        115                 120                 125             


Ser Lys Ala Ala Gly Val Phe Gly Phe Phe Ala Thr Ile Val Phe Ala 
    130                 135                 140                 


Thr Asp Phe Tyr Leu Ile Phe Asn Asp Val Ala Lys Phe Leu Lys Gln 
145                 150                 155                 160 


Gly Asp Ser Ala Asp Glu Thr Thr Ala His Lys Thr Glu Glu Glu Asn 
                165                 170                 175     


Ser Asp Ser Asp Ser Asp 
            180         


<210>  112
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Ala Ala Gly Arg Leu Pro Ser Ser Trp Ala Leu Phe Ser Pro 
1               5                   10                  15      


Leu Leu Ala Gly Leu Ala Leu Leu Gly Val Gly Pro Val Pro Ala Arg 
            20                  25                  30          


Ala Leu His Asn Val Thr Ala Glu Leu Phe Gly Ala Glu Ala Trp Gly 
        35                  40                  45              


Thr Leu Ala Ala Phe Gly Asp Leu Asn Ser Asp Lys Gln Thr Asp Leu 
    50                  55                  60                  


Phe Val Leu Arg Glu Arg Asn Asp Leu Ile Val Phe Leu Ala Asp Gln 
65                  70                  75                  80  


Asn Ala Pro Tyr Phe Lys Pro Lys Val Lys Val Ser Phe Lys Asn His 
                85                  90                  95      


Ser Ala Leu Ile Thr Ser Val Val Pro Gly Asp Tyr Asp Gly Asp Ser 
            100                 105                 110         


Gln Met Asp Val Leu Leu Thr Tyr Leu Pro Lys Asn Tyr Ala Lys Ser 
        115                 120                 125             


Glu Leu Gly Ala Val Ile Phe Trp Gly Gln Asn Gln Thr Leu Asp Pro 
    130                 135                 140                 


Asn Asn Met Thr Ile Leu Asn Arg Thr Phe Gln Asp Glu Pro Leu Ile 
145                 150                 155                 160 


Met Asp Phe Asn Gly Asp Leu Ile Pro Asp Ile Phe Gly Ile Thr Asn 
                165                 170                 175     


Glu Ser Asn Gln Pro Gln Ile Leu Leu Gly Gly Asn Leu Ser Trp His 
            180                 185                 190         


Pro Ala Leu Thr Thr Thr Ser Lys Met Arg Ile Pro His Ser His Ala 
        195                 200                 205             


Phe Ile Asp Leu Thr Glu Asp Phe Thr Ala Asp Leu Phe Leu Thr Thr 
    210                 215                 220                 


Leu Asn Ala Thr Thr Ser Thr Phe Gln Phe Glu Ile Trp Glu Asn Leu 
225                 230                 235                 240 


Asp Gly Asn Phe Ser Val Ser Thr Ile Leu Glu Lys Pro Gln Asn Met 
                245                 250                 255     


Met Val Val Gly Gln Ser Ala Phe Ala Asp Phe Asp Gly Asp Gly His 
            260                 265                 270         


Met Asp His Leu Leu Pro Gly Cys Glu Asp Lys Asn Cys Gln Lys Ser 
        275                 280                 285             


Thr Ile Tyr Leu Val Arg Ser Gly Met Lys Gln Trp Val Pro Val Leu 
    290                 295                 300                 


Gln Asp Phe Ser Asn Lys Gly Thr Leu Trp Gly Phe Val Pro Phe Val 
305                 310                 315                 320 


Asp Glu Gln Gln Pro Thr Glu Ile Pro Ile Pro Ile Thr Leu His Ile 
                325                 330                 335     


Gly Asp Tyr Asn Met Asp Gly Tyr Pro Asp Ala Leu Val Ile Leu Lys 
            340                 345                 350         


Asn Thr Ser Gly Ser Asn Gln Gln Ala Phe Leu Leu Glu Asn Val Pro 
        355                 360                 365             


Cys Asn Asn Ala Ser Cys Glu Glu Ala Arg Arg Met Phe Lys Val Tyr 
    370                 375                 380                 


Trp Glu Leu Thr Asp Leu Asn Gln Ile Lys Asp Ala Met Val Ala Thr 
385                 390                 395                 400 


Phe Phe Asp Ile Tyr Glu Asp Gly Ile Leu Asp Ile Val Val Leu Ser 
                405                 410                 415     


Lys Gly Tyr Thr Lys Asn Asp Phe Ala Ile His Thr Leu Lys Asn Asn 
            420                 425                 430         


Phe Glu Ala Asp Ala Tyr Phe Val Lys Val Ile Val Leu Ser Gly Leu 
        435                 440                 445             


Cys Ser Asn Asp Cys Pro Arg Lys Ile Thr Pro Phe Gly Val Asn Gln 
    450                 455                 460                 


Pro Gly Pro Tyr Ile Met Tyr Thr Thr Val Asp Ala Asn Gly Tyr Leu 
465                 470                 475                 480 


Lys Asn Gly Ser Ala Gly Gln Leu Ser Gln Ser Ala His Leu Ala Leu 
                485                 490                 495     


Gln Leu Pro Tyr Asn Val Leu Gly Leu Gly Arg Ser Ala Asn Phe Leu 
            500                 505                 510         


Asp His Leu Tyr Val Gly Ile Pro Arg Pro Ser Gly Glu Lys Ser Ile 
        515                 520                 525             


Arg Lys Gln Glu Trp Thr Ala Ile Ile Pro Asn Ser Gln Leu Ile Val 
    530                 535                 540                 


Ile Pro Tyr Pro His Asn Val Pro Arg Ser Trp Ser Ala Lys Leu Tyr 
545                 550                 555                 560 


Leu Thr Pro Ser Asn Ile Val Leu Leu Thr Ala Ile Ala Leu Ile Gly 
                565                 570                 575     


Val Cys Val Phe Ile Leu Ala Ile Ile Gly Ile Leu His Trp Gln Glu 
            580                 585                 590         


Lys Lys Ala Asp Asp Arg Glu Lys Arg Gln Glu Ala His Arg Phe His 
        595                 600                 605             


Phe Asp Ala Met 
    610         


<210>  113
<211>  1213
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Arg Ser Arg Asn Gln Gly Gly Glu Ser Ala Ser Asp Gly His Ile 
1               5                   10                  15      


Ser Cys Pro Lys Pro Ser Ile Ile Gly Asn Ala Gly Glu Lys Ser Leu 
            20                  25                  30          


Ser Glu Asp Ala Lys Lys Lys Lys Lys Ser Asn Arg Lys Glu Asp Asp 
        35                  40                  45              


Val Met Ala Ser Gly Thr Val Lys Arg His Leu Lys Thr Ser Gly Glu 
    50                  55                  60                  


Cys Glu Arg Lys Thr Lys Lys Ser Leu Glu Leu Ser Lys Glu Asp Leu 
65                  70                  75                  80  


Ile Gln Leu Leu Ser Ile Met Glu Gly Glu Leu Gln Ala Arg Glu Asp 
                85                  90                  95      


Val Ile His Met Leu Lys Thr Glu Lys Thr Lys Pro Glu Val Leu Glu 
            100                 105                 110         


Ala His Tyr Gly Ser Ala Glu Pro Glu Lys Val Leu Arg Val Leu His 
        115                 120                 125             


Arg Asp Ala Ile Leu Ala Gln Glu Lys Ser Ile Gly Glu Asp Val Tyr 
    130                 135                 140                 


Glu Lys Pro Ile Ser Glu Leu Asp Arg Leu Glu Glu Lys Gln Lys Glu 
145                 150                 155                 160 


Thr Tyr Arg Arg Met Leu Glu Gln Leu Leu Leu Ala Glu Lys Cys His 
                165                 170                 175     


Arg Arg Thr Val Tyr Glu Leu Glu Asn Glu Lys His Lys His Thr Asp 
            180                 185                 190         


Tyr Met Asn Lys Ser Asp Asp Phe Thr Asn Leu Leu Glu Gln Glu Arg 
        195                 200                 205             


Glu Arg Leu Lys Lys Leu Leu Glu Gln Glu Lys Ala Tyr Gln Ala Arg 
    210                 215                 220                 


Lys Glu Lys Glu Asn Ala Lys Arg Leu Asn Lys Leu Arg Asp Glu Leu 
225                 230                 235                 240 


Val Lys Leu Lys Ser Phe Ala Leu Met Leu Val Asp Glu Arg Gln Met 
                245                 250                 255     


His Ile Glu Gln Leu Gly Leu Gln Ser Gln Lys Val Gln Asp Leu Thr 
            260                 265                 270         


Gln Lys Leu Arg Glu Glu Glu Glu Lys Leu Lys Ala Ile Thr Ser Lys 
        275                 280                 285             


Ser Lys Glu Asp Arg Gln Lys Leu Leu Lys Leu Glu Val Asp Phe Glu 
    290                 295                 300                 


His Lys Ala Ser Arg Phe Ser Gln Glu His Glu Glu Met Asn Ala Lys 
305                 310                 315                 320 


Leu Ala Asn Gln Glu Ser His Asn Arg Gln Leu Arg Leu Lys Leu Val 
                325                 330                 335     


Gly Leu Thr Gln Arg Ile Glu Glu Leu Glu Glu Thr Asn Lys Asn Leu 
            340                 345                 350         


Gln Lys Ala Glu Glu Glu Leu Gln Glu Leu Arg Asp Lys Ile Ala Lys 
        355                 360                 365             


Gly Glu Cys Gly Asn Ser Ser Leu Met Ala Glu Val Glu Asn Leu Arg 
    370                 375                 380                 


Lys Arg Val Leu Glu Met Glu Gly Lys Asp Glu Glu Ile Thr Lys Thr 
385                 390                 395                 400 


Glu Ser Gln Cys Arg Glu Leu Arg Lys Lys Leu Gln Glu Glu Glu His 
                405                 410                 415     


His Ser Lys Glu Leu Arg Leu Glu Val Glu Lys Leu Gln Lys Arg Met 
            420                 425                 430         


Ser Glu Leu Glu Lys Leu Glu Glu Ala Phe Ser Lys Ser Lys Ser Glu 
        435                 440                 445             


Cys Thr Gln Leu His Leu Asn Leu Glu Lys Glu Lys Asn Leu Thr Lys 
    450                 455                 460                 


Asp Leu Leu Asn Glu Leu Glu Val Val Lys Ser Arg Val Lys Glu Leu 
465                 470                 475                 480 


Glu Cys Ser Glu Ser Arg Leu Glu Lys Ala Glu Leu Ser Leu Lys Asp 
                485                 490                 495     


Asp Leu Thr Lys Leu Lys Ser Phe Thr Val Met Leu Val Asp Glu Arg 
            500                 505                 510         


Lys Asn Met Met Glu Lys Ile Lys Gln Glu Glu Arg Lys Val Asp Gly 
        515                 520                 525             


Leu Asn Lys Asn Phe Lys Val Glu Gln Gly Lys Val Met Asp Val Thr 
    530                 535                 540                 


Glu Lys Leu Ile Glu Glu Ser Lys Lys Leu Leu Lys Leu Lys Ser Glu 
545                 550                 555                 560 


Met Glu Glu Lys Val Tyr Asn Leu Thr Arg Glu Arg Asp Glu Leu Ile 
                565                 570                 575     


Gly Lys Leu Lys Ser Glu Glu Glu Lys Ser Ser Glu Leu Ser Cys Ser 
            580                 585                 590         


Val Asp Leu Leu Lys Lys Arg Leu Asp Gly Ile Glu Glu Val Glu Arg 
        595                 600                 605             


Glu Ile Thr Arg Gly Arg Ser Arg Lys Gly Ser Glu Leu Thr Cys Pro 
    610                 615                 620                 


Glu Asp Asn Lys Ile Lys Glu Leu Thr Leu Glu Ile Glu Arg Leu Lys 
625                 630                 635                 640 


Lys Arg Leu Gln Gln Leu Glu Val Val Glu Gly Asp Leu Met Lys Thr 
                645                 650                 655     


Glu Asp Glu Tyr Asp Gln Leu Glu Gln Lys Phe Arg Thr Glu Gln Asp 
            660                 665                 670         


Lys Ala Asn Phe Leu Ser Gln Gln Leu Glu Glu Ile Lys His Gln Ile 
        675                 680                 685             


Ala Lys Asn Lys Ala Ile Glu Lys Gly Glu Val Val Ser Gln Glu Ala 
    690                 695                 700                 


Glu Leu Arg His Arg Phe Arg Leu Glu Glu Ala Lys Ser Arg Asp Leu 
705                 710                 715                 720 


Lys Ala Glu Val Gln Ala Leu Lys Glu Lys Ile His Glu Leu Met Asn 
                725                 730                 735     


Lys Glu Asp Gln Leu Ser Gln Leu Gln Val Asp Tyr Ser Val Leu Gln 
            740                 745                 750         


Gln Arg Phe Met Glu Glu Glu Asn Lys Asn Lys Asn Met Gly Gln Glu 
        755                 760                 765             


Val Leu Asn Leu Thr Lys Glu Leu Glu Leu Ser Lys Arg Tyr Ser Arg 
    770                 775                 780                 


Ala Leu Arg Pro Ser Val Asn Gly Arg Arg Met Val Asp Val Pro Val 
785                 790                 795                 800 


Thr Ser Thr Gly Val Gln Thr Asp Ala Val Ser Gly Glu Ala Ala Glu 
                805                 810                 815     


Glu Glu Thr Pro Ala Val Phe Ile Arg Lys Ser Phe Gln Glu Glu Asn 
            820                 825                 830         


His Ile Met Ser Asn Leu Arg Gln Val Gly Leu Lys Lys Pro Val Glu 
        835                 840                 845             


Arg Ser Ser Val Leu Asp Arg Tyr Pro Pro Ala Ala Asn Glu Leu Thr 
    850                 855                 860                 


Met Arg Lys Ser Trp Ile Pro Trp Met Arg Lys Arg Glu Asn Gly Pro 
865                 870                 875                 880 


Ser Ile Thr Gln Glu Lys Gly Pro Arg Thr Asn Ser Ser Pro Gly His 
                885                 890                 895     


Pro Gly Glu Val Val Leu Ser Pro Lys Gln Gly Gln Pro Leu His Ile 
            900                 905                 910         


Arg Val Thr Pro Asp His Glu Asn Ser Thr Ala Thr Leu Glu Ile Thr 
        915                 920                 925             


Ser Pro Thr Ser Glu Glu Phe Phe Ser Ser Thr Thr Val Ile Pro Thr 
    930                 935                 940                 


Leu Gly Asn Gln Lys Pro Arg Ile Thr Ile Ile Pro Ser Pro Asn Val 
945                 950                 955                 960 


Met Pro Gln Lys Gln Lys Ser Gly Asp Thr Thr Leu Gly Pro Glu Arg 
                965                 970                 975     


Ala Met Ser Pro Val Thr Ile Thr Thr Phe Ser Arg Glu Lys Thr Pro 
            980                 985                 990         


Glu Ser Gly Arg Gly Ala Phe Ala  Asp Arg Pro Thr Ser  Pro Ile Gln 
        995                 1000                 1005             


Ile Met  Thr Val Ser Thr Ser  Ala Ala Pro Ala Glu  Ile Ala Val 
    1010                 1015                 1020             


Ser Pro  Glu Ser Gln Glu Met  Pro Met Gly Arg Thr  Ile Leu Lys 
    1025                 1030                 1035             


Val Thr  Pro Glu Lys Gln Thr  Val Pro Thr Pro Val  Arg Lys Tyr 
    1040                 1045                 1050             


Asn Ser  Asn Ala Asn Ile Ile  Thr Thr Glu Asp Asn  Lys Ile His 
    1055                 1060                 1065             


Ile His  Leu Gly Ser Gln Phe  Lys Arg Ser Pro Gly  Thr Ser Gly 
    1070                 1075                 1080             


Glu Gly  Val Ser Pro Val Ile  Thr Val Arg Pro Val  Asn Val Thr 
    1085                 1090                 1095             


Ala Glu  Lys Glu Val Ser Thr  Gly Thr Val Leu Arg  Ser Pro Arg 
    1100                 1105                 1110             


Asn His  Leu Ser Ser Arg Pro  Gly Ala Ser Lys Val  Thr Ser Thr 
    1115                 1120                 1125             


Ile Thr  Ile Thr Pro Val Thr  Thr Ser Ser Ala Arg  Gly Thr Gln 
    1130                 1135                 1140             


Ser Val  Ser Gly Gln Asp Gly  Ser Ser Gln Arg Pro  Thr Pro Thr 
    1145                 1150                 1155             


Arg Ile  Pro Met Ser Lys Gly  Met Lys Ala Gly Lys  Pro Val Val 
    1160                 1165                 1170             


Ala Ala  Pro Gly Ala Gly Asn  Leu Thr Lys Phe Glu  Pro Arg Ala 
    1175                 1180                 1185             


Glu Thr  Gln Ser Met Lys Ile  Glu Leu Lys Lys Ser  Ala Ala Ser 
    1190                 1195                 1200             


Ser Thr  Thr Ser Leu Gly Gly  Gly Lys Gly 
    1205                 1210             


<210>  114
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Ser Val Ala Leu Glu Asp Val Ala Val Asn Phe Thr Arg Glu 
1               5                   10                  15      


Glu Trp Ala Leu Leu Gly Pro Cys Gln Lys Asn Leu Tyr Lys Asp Val 
            20                  25                  30          


Met Gln Glu Thr Ile Arg Asn Leu Asp Cys Val Gly Met Lys Trp Lys 
        35                  40                  45              


Asp Gln Asn Ile Glu Asp Gln Tyr Arg Tyr Pro Arg Lys Asn Leu Arg 
    50                  55                  60                  


Cys Arg Met Leu Glu Arg Phe Val Glu Ser Lys Asp Gly Thr Gln Cys 
65                  70                  75                  80  


Gly Glu Thr Ser Ser Gln Ile Gln Asp Ser Ile Val Thr Lys Asn Thr 
                85                  90                  95      


Leu Pro Gly Val Gly Pro Tyr Glu Ser Arg Met Ser Gly Glu Val Ile 
            100                 105                 110         


Met Gly His Ser Ser Leu Asn Cys Tyr Ile Arg Val Gly Ala Gly His 
        115                 120                 125             


Lys Pro Tyr Glu Tyr His Glu Cys Gly Glu Lys Pro Asp Thr His Lys 
    130                 135                 140                 


Gln Arg Gly Lys Ala Phe Ser Tyr His Asn Ser Leu Gln Thr His Glu 
145                 150                 155                 160 


Arg Leu His Thr Gly Lys Lys Pro Tyr Asn Cys Lys Glu Cys Gly Lys 
                165                 170                 175     


Ser Phe Ser Ser Leu Gly Asn Leu Gln Arg His Met Ala Val Gln Arg 
            180                 185                 190         


Gly Asp Gly Pro Tyr Lys Cys Lys Leu Cys Gly Lys Ala Phe Phe Trp 
        195                 200                 205             


Pro Ser Leu Leu His Met His Glu Arg Thr His Thr Gly Glu Lys Pro 
    210                 215                 220                 


Tyr Glu Cys Lys Gln Cys Ser Lys Ala Phe Ser Phe Tyr Ser Ser Tyr 
225                 230                 235                 240 


Leu Arg His Glu Arg Thr His Thr Gly Glu Lys Leu Tyr Glu Cys Lys 
                245                 250                 255     


Gln Cys Ser Lys Ala Phe Pro Asp Tyr Ser Ser Cys Leu Arg His Glu 
            260                 265                 270         


Arg Thr His Thr Gly Lys Lys Pro Tyr Thr Cys Lys Gln Cys Gly Lys 
        275                 280                 285             


Ala Phe Ser Ala Ser Thr Ser Leu Arg Arg His Glu Thr Thr His Thr 
    290                 295                 300                 


Asp Glu Lys Pro Tyr Ala Cys Gln Gln Cys Gly Lys Ala Phe His His 
305                 310                 315                 320 


Leu Gly Ser Phe Gln Arg His Met Val Met His Thr Arg Asp Gly Pro 
                325                 330                 335     


His Lys Cys Lys Ile Cys Gly Lys Gly Phe Asp Cys Pro Ser Ser Leu 
            340                 345                 350         


Lys Ser His Glu Arg Thr His Thr Gly Glu Lys Leu Tyr Glu Cys Lys 
        355                 360                 365             


Gln Cys Gly Lys Ala Leu Ser His Ser Ser Ser Phe Arg Arg His Met 
    370                 375                 380                 


Thr Met His Thr Gly Asp Gly Pro His Lys Cys Lys Ile Cys Gly Lys 
385                 390                 395                 400 


Ala Phe Val Tyr Pro Ser Val Phe Gln Arg His Glu Lys Thr His Thr 
                405                 410                 415     


Ala Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys Ala Tyr Arg Ile 
            420                 425                 430         


Ser Ser Ser Leu Arg Arg His Glu Thr Thr His Thr Gly Glu Lys Pro 
        435                 440                 445             


Tyr Lys Cys Lys Cys Gly Lys Ala Phe Ile Asp Phe Tyr Ser Phe Gln 
    450                 455                 460                 


Asn His Lys Thr Thr His Ala Gly Glu Lys Pro Tyr Glu Cys Lys Glu 
465                 470                 475                 480 


Cys Gly Lys Ala Phe Ser Cys Phe Gln Tyr Leu Ser Gln His Arg Arg 
                485                 490                 495     


Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Thr Cys Lys Lys Ala 
            500                 505                 510         


Phe Ser His Phe Gly Asn Leu Lys Val His Glu Arg Ile His Ser Gly 
        515                 520                 525             


Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Trp Leu 
    530                 535                 540                 


Thr Cys Phe Leu Arg His Glu Arg Ile His Met Arg Glu Lys Pro Tyr 
545                 550                 555                 560 


Glu Cys Gln Gln Cys Gly Lys Ala Phe Thr His Ser Arg Phe Leu Gln 
                565                 570                 575     


Gly His Glu Lys Thr His Thr Gly Glu Asn Pro Tyr Glu Cys Lys Glu 
            580                 585                 590         


Cys Gly Lys Ala Phe Ala Ser Leu Ser Ser Leu His Arg His Lys Lys 
        595                 600                 605             


Thr His Trp Lys Lys Thr His Thr Gly Glu Asn Pro Tyr Gly Cys Lys 
    610                 615                 620                 


Glu Cys Gly Lys Ala Phe Ala Ser Leu Ser Ser Leu His Arg His Lys 
625                 630                 635                 640 


Lys Thr His 
            


<210>  115
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu Lys Tyr Phe 
1               5                   10                  15      


Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu Thr Asp Asp 
            20                  25                  30          


Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45              


Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser His Met Val 
    50                  55                  60                  


Met Lys Asp Lys Asn Arg His Asp Lys Asp Gln Gln His Arg Gln Trp 
65                  70                  75                  80  


Phe Leu Lys Glu Phe Pro Arg Leu Lys Arg Glu Leu Glu Asp His Ile 
                85                  90                  95      


Arg Lys Leu Arg Ala Leu Ala Glu Glu Val Glu Gln Val His Arg Gly 
            100                 105                 110         


Thr Thr Ile Ala Asn Val Val Ser Asn Ser Val Gly Thr Thr Ser Gly 
        115                 120                 125             


Ile Leu Thr Leu Leu Gly Leu Gly Leu Ala Pro Phe Thr Glu Gly Ile 
    130                 135                 140                 


Ser Phe Val Leu Leu Asp Thr Gly Met Gly Leu Gly Ala Ala Ala Ala 
145                 150                 155                 160 


Val Ala Gly Ile Thr Cys Ser Val Val Glu Leu Val Asn Lys Leu Arg 
                165                 170                 175     


Ala Arg Ala Gln Ala Arg Asn Leu Asp Gln Ser Gly Thr Asn Val Ala 
            180                 185                 190         


Lys Val Met Lys Glu Phe Val Gly Gly Asn Thr Pro Asn Val Leu Thr 
        195                 200                 205             


Leu Val Asp Asn Trp Tyr Gln Val Thr Gln Gly Ile Gly Arg Asn Ile 
    210                 215                 220                 


Arg Ala Ile Arg Arg Ala Arg Ala Asn Pro Gln Leu Gly Ala Tyr Ala 
225                 230                 235                 240 


Pro Pro Pro His Ile Ile Gly Arg Ile Ser Ala Glu Gly Gly Glu Gln 
                245                 250                 255     


Val Glu Arg Val Val Glu Gly Pro Ala Gln Ala Met Ser Arg Gly Thr 
            260                 265                 270         


Met Ile Val Gly Ala Ala Thr Gly Gly Ile Leu Leu Leu Leu Asp Val 
        275                 280                 285             


Val Ser Leu Ala Tyr Glu Ser Lys His Leu Leu Glu Gly Ala Lys Ser 
    290                 295                 300                 


Glu Ser Ala Glu Glu Leu Lys Lys Arg Ala Gln Glu Leu Glu Gly Lys 
305                 310                 315                 320 


Leu Asn Phe Leu Thr Lys Ile His Glu Met Leu Gln Pro Gly Gln Asp 
                325                 330                 335     


Gln 
    


<210>  116
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Ala Leu Asn Lys Lys Glu Asn Lys Gly Cys 
                85                  90                  95      


Glu Ser Pro Asp Pro Asp Ser Ser Tyr Ala Leu Thr Pro Arg Thr Glu 
            100                 105                 110         


Glu Lys Tyr Lys Lys Ile Asn Glu Glu Phe Asp Asn Met Ile Lys Ser 
        115                 120                 125             


His Lys Ile Pro Ala Val Pro Pro Pro Asn Phe Glu Met Pro Val Ser 
    130                 135                 140                 


Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro Val Ser 
145                 150                 155                 160 


Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser Leu Gln 
                165                 170                 175     


Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser Ala Gly 
            180                 185                 190         


Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala Gly Thr 
        195                 200                 205             


Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly Leu Leu 
    210                 215                 220                 


Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser Pro Pro 
225                 230                 235                 240 


Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg Val Leu 
                245                 250                 255     


Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Asn Gln Arg Ile 
            260                 265                 270         


Asn Asn Ser Gln Ser Ala Gln Ser Leu Ala Thr Pro Val Val Ser Val 
        275                 280                 285             


Ala Thr Pro Thr Leu Pro Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala 
    290                 295                 300                 


Ile Ser Thr Thr Tyr Gly Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu 
305                 310                 315                 320 


Ser Ser Leu Ser Gly Phe Asn Thr Ala Ser Ala Leu His Leu Gly Ser 
                325                 330                 335     


Val Thr Gly Trp Gln Gln Gln His Leu His Asn Met Pro Pro Ser Ala 
            340                 345                 350         


Leu Ser Gln Leu Gly Ala Cys Thr Ser Thr His Leu Ser Gln Ser Ser 
        355                 360                 365             


Asn Leu Ser Leu Pro Ser Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro 
    370                 375                 380                 


Val Ser Pro Pro Arg Asp Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln 
385                 390                 395                 400 


His Thr Arg His Glu Ala Gly Arg Ser Pro Val Asp Ser Leu Ser Ser 
                405                 410                 415     


Cys Ser Ser Ser Tyr Asp Gly Ser Asp Arg Glu Asp His Arg Asn Glu 
            420                 425                 430         


Phe His Ser Pro Ile Gly Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu 
        435                 440                 445             


Ser Pro Ser Val Lys Arg Met Arg Leu Ser Glu Gly Trp Ala Thr 
    450                 455                 460             


<210>  117
<211>  704
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Ala Asn Glu Asn His Gly Ser Pro Arg Glu Glu Ala Ser Leu Leu 
1               5                   10                  15      


Ser His Ser Pro Gly Thr Ser Asn Gln Ser Gln Pro Cys Ser Pro Lys 
            20                  25                  30          


Pro Ile Arg Leu Val Gln Asp Leu Pro Glu Glu Leu Val His Ala Gly 
        35                  40                  45              


Trp Glu Lys Cys Trp Ser Arg Arg Glu Asn Arg Pro Tyr Tyr Phe Asn 
    50                  55                  60                  


Arg Phe Thr Asn Gln Ser Leu Trp Glu Met Pro Val Leu Gly Gln His 
65                  70                  75                  80  


Asp Val Ile Ser Asp Pro Leu Gly Leu Asn Ala Thr Pro Leu Pro Gln 
                85                  90                  95      


Asp Ser Ser Leu Val Glu Thr Pro Pro Ala Glu Asn Lys Pro Arg Lys 
            100                 105                 110         


Arg Gln Leu Ser Glu Glu Gln Pro Ser Gly Asn Gly Val Lys Lys Pro 
        115                 120                 125             


Lys Ile Glu Ile Pro Val Thr Pro Thr Gly Gln Ser Val Pro Ser Ser 
    130                 135                 140                 


Pro Ser Ile Pro Gly Thr Pro Thr Leu Lys Met Trp Gly Thr Ser Pro 
145                 150                 155                 160 


Glu Asp Lys Gln Gln Ala Ala Leu Leu Arg Pro Thr Glu Val Tyr Trp 
                165                 170                 175     


Asp Leu Asp Ile Gln Thr Asn Ala Val Ile Lys His Arg Gly Pro Ser 
            180                 185                 190         


Glu Val Leu Pro Pro His Pro Glu Val Glu Leu Leu Arg Ser Gln Leu 
        195                 200                 205             


Ile Leu Lys Leu Arg Gln His Tyr Arg Glu Leu Cys Gln Gln Arg Glu 
    210                 215                 220                 


Gly Ile Glu Pro Pro Arg Glu Ser Phe Asn Arg Trp Met Leu Glu Arg 
225                 230                 235                 240 


Lys Val Val Asp Lys Gly Ser Asp Pro Leu Leu Pro Ser Asn Cys Glu 
                245                 250                 255     


Pro Val Val Ser Pro Ser Met Phe Arg Glu Ile Met Asn Asp Ile Pro 
            260                 265                 270         


Ile Arg Leu Ser Arg Ile Lys Phe Arg Glu Glu Ala Lys Arg Leu Leu 
        275                 280                 285             


Phe Lys Tyr Ala Glu Ala Ala Arg Arg Leu Ile Glu Ser Arg Ser Ala 
    290                 295                 300                 


Ser Pro Asp Ser Arg Lys Val Val Lys Trp Asn Val Glu Asp Thr Phe 
305                 310                 315                 320 


Ser Trp Leu Arg Lys Asp His Ser Ala Ser Lys Glu Asp Tyr Met Asp 
                325                 330                 335     


Arg Leu Glu His Leu Arg Arg Gln Cys Gly Pro His Val Ser Ala Ala 
            340                 345                 350         


Ala Lys Asp Ser Val Glu Gly Ile Cys Ser Lys Ile Tyr His Ile Ser 
        355                 360                 365             


Leu Glu Tyr Val Lys Arg Ile Arg Glu Lys His Leu Ala Ile Leu Lys 
    370                 375                 380                 


Glu Asn Asn Ile Ser Glu Glu Val Glu Ala Pro Glu Val Glu Pro Arg 
385                 390                 395                 400 


Leu Val Tyr Cys Tyr Pro Val Arg Leu Ala Val Ser Ala Pro Pro Met 
                405                 410                 415     


Pro Ser Val Glu Met His Met Glu Asn Asn Val Val Cys Ile Arg Tyr 
            420                 425                 430         


Lys Gly Glu Met Val Lys Val Ser Arg Asn Tyr Phe Ser Lys Leu Trp 
        435                 440                 445             


Leu Leu Tyr Arg Tyr Ser Cys Ile Asp Asp Ser Ala Phe Glu Arg Phe 
    450                 455                 460                 


Leu Pro Arg Val Trp Cys Leu Leu Arg Arg Tyr Gln Met Met Phe Gly 
465                 470                 475                 480 


Val Gly Leu Tyr Glu Gly Thr Gly Leu Gln Gly Ser Leu Pro Val His 
                485                 490                 495     


Val Phe Glu Ala Leu His Arg Leu Phe Gly Val Ser Phe Glu Cys Phe 
            500                 505                 510         


Ala Ser Pro Leu Asn Cys Tyr Phe Arg Gln Tyr Cys Ser Ala Phe Pro 
        515                 520                 525             


Asp Thr Asp Gly Tyr Phe Gly Ser Arg Gly Pro Cys Leu Asp Phe Ala 
    530                 535                 540                 


Pro Leu Ser Gly Ser Phe Glu Ala Asn Pro Pro Phe Cys Glu Glu Leu 
545                 550                 555                 560 


Met Asp Ala Met Val Ser His Phe Glu Arg Leu Leu Glu Ser Ser Pro 
                565                 570                 575     


Glu Pro Leu Ser Phe Ile Val Phe Ile Pro Glu Trp Arg Glu Pro Pro 
            580                 585                 590         


Thr Pro Ala Leu Thr Arg Met Glu Gln Ser Arg Phe Lys Arg His Gln 
        595                 600                 605             


Leu Ile Leu Pro Ala Phe Glu His Glu Tyr Arg Ser Gly Ser Gln His 
    610                 615                 620                 


Ile Cys Lys Lys Glu Glu Met His Tyr Lys Ala Val His Asn Thr Ala 
625                 630                 635                 640 


Val Leu Phe Leu Gln Asn Asp Pro Gly Phe Ala Lys Trp Ala Pro Thr 
                645                 650                 655     


Pro Glu Arg Leu Gln Glu Leu Ser Ala Ala Tyr Arg Gln Ser Gly Arg 
            660                 665                 670         


Ser His Ser Ser Gly Ser Ser Ser Ser Ser Ser Ser Glu Ala Lys Asp 
        675                 680                 685             


Arg Asp Ser Gly Arg Glu Gln Gly Pro Ser Arg Glu Pro His Pro Thr 
    690                 695                 700                 


<210>  118
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Ser Ile Val Thr Val Gln Leu Gly Gln Cys Gly Asn Gln Ile Gly 
1               5                   10                  15      


Phe Glu Val Phe Asp Ala Leu Leu Ser Asp Ser His Ser Ser Gln Gly 
            20                  25                  30          


Leu Cys Ser Met Arg Glu Asn Glu Ala Tyr Gln Ala Ser Cys Lys Glu 
        35                  40                  45              


Arg Phe Phe Ser Glu Glu Glu Asn Gly Val Pro Ile Ala Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Met Glu Pro Lys Val Ile Asn Gln Met Leu Ser Lys Ala 
65                  70                  75                  80  


Ala Gln Ser Gly Gln Trp Lys Tyr Gly Gln His Ala Cys Phe Cys Gln 
                85                  90                  95      


Lys Gln Gly Ser Gly Asn Asn Trp Ala Tyr Gly Tyr Ser Val His Gly 
            100                 105                 110         


Pro Arg His Glu Glu Ser Ile Met Asn Ile Ile Arg Lys Glu Val Glu 
        115                 120                 125             


Lys Cys Asp Ser Phe Ser Gly Phe Phe Ile Ile Met Ser Met Ala Gly 
    130                 135                 140                 


Gly Thr Gly Ser Gly Leu Gly Ala Phe Val Thr Gln Asn Leu Glu Asp 
145                 150                 155                 160 


Gln Tyr Ser Asn Ser Leu Lys Met Asn Gln Ile Ile Trp Pro Tyr Gly 
                165                 170                 175     


Thr Gly Glu Val Ile Val Gln Asn Tyr Asn Ser Ile Leu Thr Leu Ser 
            180                 185                 190         


His Leu Tyr Arg Ser Ser Asp Ala Leu Leu Leu His Glu Asn Asp Ala 
        195                 200                 205             


Ile His Lys Ile Cys Ala Lys Leu Met Asn Ile Lys Gln Ile Ser Phe 
    210                 215                 220                 


Ser Asp Ile Asn Gln Val Leu Ala His Gln Leu Gly Ser Val Phe Gln 
225                 230                 235                 240 


Pro Thr Tyr Ser Ala Glu Ser Ser Phe His Tyr Arg Arg Asn Pro Leu 
                245                 250                 255     


Gly Asp Leu Met Glu His Leu Val Pro His Pro Glu Phe Lys Met Leu 
            260                 265                 270         


Ser Val Arg Asn Ile Pro His Met Ser Glu Asn Ser Leu Ala Tyr Thr 
        275                 280                 285             


Thr Phe Thr Trp Ala Gly Leu Leu Lys His Leu Arg Gln Met Leu Ile 
    290                 295                 300                 


Ser Asn Ala Lys Met Glu Glu Gly Ile Asp Arg His Val Trp Pro Pro 
305                 310                 315                 320 


Leu Ser Gly Leu Pro Pro Leu Ser Lys Met Ser Leu Asn Lys Asp Leu 
                325                 330                 335     


His Phe Asn Thr Ser Ile Ala Asn Leu Val Ile Leu Arg Gly Lys Asp 
            340                 345                 350         


Val Gln Ser Ala Asp Val Gly Lys Lys Phe Arg Ala Tyr Ile His Gln 
        355                 360                 365             


Tyr Thr Lys Phe Gly Ile Glu Glu Glu Asp Phe Leu Asp Ser Phe Thr 
    370                 375                 380                 


Ser Leu Glu Gln Val Val Ala Ser Tyr Cys Asn Leu 
385                 390                 395     


<210>  119
<211>  1158
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Thr His Gly Glu Glu Leu Gly Ser Asp Val His Gln Asp Ser Ile 
1               5                   10                  15      


Val Leu Thr Tyr Leu Glu Gly Leu Leu Met His Gln Ala Ala Gly Gly 
            20                  25                  30          


Ser Gly Thr Ala Val Asp Lys Lys Ser Ala Gly His Asn Glu Glu Asp 
        35                  40                  45              


Gln Asn Phe Asn Ile Ser Gly Ser Ala Phe Pro Thr Cys Gln Ser Asn 
    50                  55                  60                  


Gly Pro Val Leu Asn Thr His Thr Tyr Gln Gly Ser Gly Met Leu His 
65                  70                  75                  80  


Leu Lys Lys Ala Arg Leu Leu Gln Ser Ser Glu Asp Trp Asn Ala Ala 
                85                  90                  95      


Lys Arg Lys Arg Leu Ser Asp Ser Ile Met Asn Leu Asn Val Lys Lys 
            100                 105                 110         


Glu Ala Leu Leu Ala Gly Met Val Asp Ser Val Pro Lys Gly Lys Gln 
        115                 120                 125             


Asp Ser Thr Leu Leu Ala Ser Leu Leu Gln Ser Phe Ser Ser Arg Leu 
    130                 135                 140                 


Gln Thr Val Ala Leu Ser Gln Gln Ile Arg Gln Ser Leu Lys Glu Gln 
145                 150                 155                 160 


Gly Tyr Ala Leu Ser His Asp Ser Leu Lys Val Glu Lys Asp Leu Arg 
                165                 170                 175     


Cys Tyr Gly Val Ala Ser Ser His Leu Lys Thr Leu Leu Lys Lys Ser 
            180                 185                 190         


Lys Val Lys Asp Gln Lys Pro Asp Thr Asn Leu Pro Asp Val Thr Lys 
        195                 200                 205             


Asn Leu Ile Arg Asp Arg Phe Ala Glu Ser Pro His His Val Gly Gln 
    210                 215                 220                 


Ser Gly Thr Lys Val Met Ser Glu Pro Leu Ser Cys Ala Ala Arg Leu 
225                 230                 235                 240 


Gln Ala Val Ala Ser Met Val Glu Lys Arg Ala Ser Pro Ala Thr Ser 
                245                 250                 255     


Pro Lys Pro Ser Val Ala Cys Ser Gln Leu Ala Leu Leu Leu Ser Ser 
            260                 265                 270         


Glu Ala His Leu Gln Gln Tyr Ser Arg Glu His Ala Leu Lys Thr Gln 
        275                 280                 285             


Asn Ala Asn Gln Ala Ala Ser Glu Arg Leu Ala Ala Met Ala Arg Leu 
    290                 295                 300                 


Gln Glu Asn Gly Gln Lys Asp Val Gly Ser Tyr Gln Leu Pro Lys Gly 
305                 310                 315                 320 


Met Ser Ser His Leu Asn Gly Gln Ala Arg Thr Ser Ser Ser Lys Leu 
                325                 330                 335     


Met Ala Ser Lys Ser Ser Ala Thr Val Phe Gln Asn Pro Met Gly Ile 
            340                 345                 350         


Ile Pro Ser Ser Pro Lys Asn Ala Gly Tyr Lys Asn Ser Leu Glu Arg 
        355                 360                 365             


Asn Asn Ile Lys Gln Ala Ala Asn Asn Ser Leu Leu Leu His Leu Leu 
    370                 375                 380                 


Lys Ser Gln Thr Ile Pro Lys Pro Met Asn Gly His Ser His Ser Glu 
385                 390                 395                 400 


Arg Gly Ser Ile Phe Glu Glu Ser Ser Thr Pro Thr Thr Ile Asp Glu 
                405                 410                 415     


Tyr Ser Asp Asn Asn Pro Ser Phe Thr Asp Asp Ser Ser Gly Asp Glu 
            420                 425                 430         


Ser Ser Tyr Ser Asn Cys Val Pro Ile Asp Leu Ser Cys Lys His Arg 
        435                 440                 445             


Thr Glu Lys Ser Glu Ser Asp Gln Pro Val Ser Leu Asp Asn Phe Thr 
    450                 455                 460                 


Gln Ser Leu Leu Asn Thr Trp Asp Pro Lys Val Pro Asp Val Asp Ile 
465                 470                 475                 480 


Lys Glu Asp Gln Asp Thr Ser Lys Asn Ser Lys Leu Asn Ser His Gln 
                485                 490                 495     


Lys Val Thr Leu Leu Gln Leu Leu Leu Gly His Lys Asn Glu Glu Asn 
            500                 505                 510         


Val Glu Lys Asn Thr Ser Pro Gln Gly Val His Asn Asp Val Ser Lys 
        515                 520                 525             


Phe Asn Thr Gln Asn Tyr Ala Arg Thr Ser Val Ile Glu Ser Pro Ser 
    530                 535                 540                 


Thr Asn Arg Thr Thr Pro Val Ser Thr Pro Pro Leu Leu Thr Ser Ser 
545                 550                 555                 560 


Lys Ala Gly Ser Pro Ile Asn Leu Ser Gln His Ser Leu Val Ile Lys 
                565                 570                 575     


Trp Asn Ser Pro Pro Tyr Val Cys Ser Thr Gln Ser Glu Lys Leu Thr 
            580                 585                 590         


Asn Thr Ala Ser Asn His Ser Met Asp Leu Thr Lys Ser Lys Asp Pro 
        595                 600                 605             


Pro Gly Glu Lys Pro Ala Gln Asn Glu Gly Ala Gln Asn Ser Ala Thr 
    610                 615                 620                 


Phe Ser Ala Ser Lys Leu Leu Gln Asn Leu Ala Gln Cys Gly Met Gln 
625                 630                 635                 640 


Ser Ser Met Ser Val Glu Glu Gln Arg Pro Ser Lys Gln Leu Leu Thr 
                645                 650                 655     


Gly Asn Thr Asp Lys Pro Ile Gly Met Ile Asp Arg Leu Asn Ser Pro 
            660                 665                 670         


Leu Leu Ser Asn Lys Thr Asn Ala Val Glu Glu Asn Lys Ala Phe Ser 
        675                 680                 685             


Ser Gln Pro Thr Gly Pro Glu Pro Gly Leu Ser Gly Ser Glu Ile Glu 
    690                 695                 700                 


Asn Leu Leu Glu Arg Arg Thr Val Leu Gln Leu Leu Leu Gly Asn Pro 
705                 710                 715                 720 


Asn Lys Gly Lys Ser Glu Lys Lys Glu Lys Thr Pro Leu Arg Asp Glu 
                725                 730                 735     


Ser Thr Gln Glu His Ser Glu Arg Ala Leu Ser Glu Gln Ile Leu Met 
            740                 745                 750         


Val Lys Ile Lys Ser Glu Pro Cys Asp Asp Leu Gln Ile Pro Asn Thr 
        755                 760                 765             


Asn Val His Leu Ser His Asp Ala Lys Ser Ala Pro Phe Leu Gly Met 
    770                 775                 780                 


Ala Pro Ala Val Gln Arg Ser Ala Pro Ala Leu Pro Val Ser Glu Asp 
785                 790                 795                 800 


Phe Lys Ser Glu Pro Val Ser Pro Gln Asp Phe Ser Phe Ser Lys Asn 
                805                 810                 815     


Gly Leu Leu Ser Arg Leu Leu Arg Gln Asn Gln Asp Ser Tyr Leu Ala 
            820                 825                 830         


Asp Asp Ser Asp Arg Ser His Arg Asn Asn Glu Met Ala Leu Leu Glu 
        835                 840                 845             


Ser Lys Asn Leu Cys Met Val Pro Lys Lys Arg Lys Leu Tyr Thr Glu 
    850                 855                 860                 


Pro Leu Glu Asn Pro Phe Lys Lys Met Lys Asn Asn Ile Val Asp Ala 
865                 870                 875                 880 


Ala Asn Asn His Ser Ala Pro Glu Val Leu Tyr Gly Ser Leu Leu Asn 
                885                 890                 895     


Gln Glu Glu Leu Lys Phe Ser Arg Asn Asp Leu Glu Phe Lys Tyr Pro 
            900                 905                 910         


Ala Gly His Gly Ser Ala Ser Glu Ser Glu His Arg Ser Trp Ala Arg 
        915                 920                 925             


Glu Ser Lys Ser Phe Asn Val Leu Lys Gln Leu Leu Leu Ser Glu Asn 
    930                 935                 940                 


Cys Val Arg Asp Leu Ser Pro His Arg Ser Asn Ser Val Ala Asp Ser 
945                 950                 955                 960 


Lys Lys Lys Gly His Lys Asn Asn Val Thr Asn Ser Lys Pro Glu Phe 
                965                 970                 975     


Ser Ile Ser Ser Leu Asn Gly Leu Met Tyr Ser Ser Thr Gln Pro Ser 
            980                 985                 990         


Ser Cys Met Asp Asn Arg Thr Phe  Ser Tyr Pro Gly Val  Val Lys Thr 
        995                 1000                 1005             


Pro Val  Ser Pro Thr Phe Pro  Glu His Leu Gly Cys  Ala Gly Ser 
    1010                 1015                 1020             


Arg Pro  Glu Ser Gly Leu Leu  Asn Gly Cys Ser Met  Pro Ser Glu 
    1025                 1030                 1035             


Lys Gly  Pro Ile Lys Trp Val  Ile Thr Asp Ala Glu  Lys Asn Glu 
    1040                 1045                 1050             


Tyr Glu  Lys Asp Ser Pro Arg  Leu Thr Lys Thr Asn  Pro Ile Leu 
    1055                 1060                 1065             


Tyr Tyr  Met Leu Gln Lys Gly  Gly Asn Ser Val Thr  Ser Arg Glu 
    1070                 1075                 1080             


Thr Gln  Asp Lys Asp Ile Trp  Arg Glu Ala Ser Ser  Ala Glu Ser 
    1085                 1090                 1095             


Val Ser  Gln Val Thr Ala Lys  Glu Glu Leu Leu Pro  Thr Ala Glu 
    1100                 1105                 1110             


Thr Lys  Ala Ser Phe Phe Asn  Leu Arg Ser Pro Tyr  Asn Ser His 
    1115                 1120                 1125             


Met Gly  Asn Asn Ala Ser Arg  Pro His Ser Ala Asn  Gly Glu Val 
    1130                 1135                 1140             


Tyr Gly  Leu Leu Gly Ser Val  Leu Thr Ile Lys Lys  Glu Ser Glu 
    1145                 1150                 1155             


<210>  120
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Leu His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp 
        355                 360                 365             


Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg 
    370                 375                 380                 


Val Ile Glu Ala Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala 
385                 390                 395                 400 


Ala Glu Pro Val Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu 
                405                 410                 415     


Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu 
            420                 425                 430         


Val Gln Met Arg Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser 
        435                 440                 445             


Tyr Arg Pro Ala Glu Val Ala Glu Thr Gly Ala 
    450                 455                 


<210>  121
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro 
                325                 330                 335     


Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu 
            340                 345                 350         


Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu 
        355                 360                 365             


Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr 
    370                 375                 380                 


Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro 
385                 390                 395                 400 


Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr 
                405                 410                 415     


Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile 
            420                 425                 430         


His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp 
        435                 440                 445             


Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro 
    450                 455                 460                 


Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe 
465                 470                 475                 480 


Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro 
                485                 490                 495     


Lys Arg Leu Thr Pro 
            500     


<210>  122
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Ile Gln Ser Ser Ser Thr Pro Thr Arg Asp Leu Ala Pro Lys Asp 
1               5                   10                  15      


Arg Asn Gly Thr Ser Asp Pro Phe Val Arg Val Arg Tyr Lys Gly Arg 
            20                  25                  30          


Thr Arg Glu Thr Ser Ile Val Lys Lys Ser Cys Tyr Pro Arg Trp Asn 
        35                  40                  45              


Glu Thr Phe Glu Phe Glu Leu Gln Glu Gly Ala Met Glu Ala Leu Cys 
    50                  55                  60                  


Val Glu Ala Trp Asp Trp Asp Leu Val Ser Arg Asn Asp Phe Leu Gly 
65                  70                  75                  80  


Lys Val Val Ile Asp Val Gln Arg Leu Arg Val Val Gln Gln Glu Glu 
                85                  90                  95      


Gly Trp Phe Arg Leu Gln Pro Asp Gln Ser Lys Ser Arg Arg His Asp 
            100                 105                 110         


Glu Gly Asn Leu Gly Ser Leu Gln Leu Glu Val Arg Leu Arg Asp Glu 
        115                 120                 125             


Thr Val Leu Pro Ser Ser Tyr Tyr Gln Pro Leu Val His Leu Leu Cys 
    130                 135                 140                 


His Glu Val Lys Leu Gly Met Gln Gly Pro Gly Gln Leu Ile Pro Leu 
145                 150                 155                 160 


Ile Glu Glu Thr Thr Ser Thr Glu Cys Arg Gln Asp Val Ala Thr Asn 
                165                 170                 175     


Leu Leu Lys Leu Phe Leu Gly Gln Gly Leu Ala Lys Asp Phe Leu Asp 
            180                 185                 190         


Leu Leu Phe Gln Leu Glu Leu Ser Arg Thr Ser Glu Thr Asn Thr Leu 
        195                 200                 205             


Phe Arg Ser Asn Ser Leu Ala Ser Lys Ser Val Glu Ser Phe Leu Lys 
    210                 215                 220                 


Val Ala Gly Met Gln Tyr Leu His Gly Val Leu Gly Pro Ile Ile Asn 
225                 230                 235                 240 


Lys Val Phe Glu Glu Lys Lys Tyr Val Glu Leu Asp Pro Ser Lys Val 
                245                 250                 255     


Glu Val Lys Asp Val Gly Cys Ser Gly Leu His Arg Pro Gln Thr Glu 
            260                 265                 270         


Ala Glu Val Leu Glu Gln Ser Ala Gln Thr Leu Arg Ala His Leu Gly 
        275                 280                 285             


Ala Leu Leu Ser Ala Leu Ser Arg Ser Val Arg Ala Cys Pro Ala Val 
    290                 295                 300                 


Val Arg Ala Thr Phe Arg Gln Leu Phe Arg Arg Val Arg Glu Arg Phe 
305                 310                 315                 320 


Pro Gly Ala Gln His Glu Asn Val Pro Phe Ile Ala Val Thr Ser Phe 
                325                 330                 335     


Leu Cys Leu Arg Phe Phe Ser Pro Ala Ile Met Ser Pro Lys Leu Phe 
            340                 345                 350         


His Leu Arg Glu Arg His Ala Asp Ala Arg Thr Ser Arg Thr Leu Leu 
        355                 360                 365             


Leu Leu Ala Lys Ala Val Gln Asn Val Gly Asn Met Asp Thr Pro Ala 
    370                 375                 380                 


Ser Arg Ala Lys Glu Ala Trp Met Glu Pro Leu Gln Pro Thr Val His 
385                 390                 395                 400 


Gln Gly Val Ala Gln Leu Lys Asp Phe Ile Thr Lys Leu Val Asp Ile 
                405                 410                 415     


Glu Glu Lys Asp Glu Leu Asp Leu Gln Arg Thr Leu Ser Leu Gln Ala 
            420                 425                 430         


Pro Pro Val Lys Glu Gly Pro Leu Phe Ile His Arg Thr Lys Gly Lys 
        435                 440                 445             


Gly Pro Leu Met Ser Ser Ser Phe Lys Lys Leu Tyr Phe Ser Leu Thr 
    450                 455                 460                 


Thr Glu Ala Leu Ser Phe Ala Lys Thr Pro Ser Ser Lys Lys Ser Ala 
465                 470                 475                 480 


Leu Ile Lys Leu Ala Asn Ile Arg Ala Ala Glu Lys Val Glu Glu Lys 
                485                 490                 495     


Ser Phe Gly Gly Ser His Val Met Gln Val Ile Tyr Thr Asp Asp Ala 
            500                 505                 510         


Gly Arg Pro Gln Thr Ala Tyr Leu Gln Cys Lys Cys Val Asn Glu Leu 
        515                 520                 525             


Asn Gln Trp Leu Ser Ala Leu Arg Lys Val Ser Ile Asn Asn Thr Gly 
    530                 535                 540                 


Leu Leu Gly Ser Tyr His Pro Gly Val Phe Arg Gly Asp Lys Trp Ser 
545                 550                 555                 560 


Cys Cys His Gln Lys Glu Lys Thr Gly Gln Gly Cys Asp Lys Thr Arg 
                565                 570                 575     


Ser Arg Val Thr Leu Gln Glu Trp Asn Asp Pro Leu Asp His Asp Leu 
            580                 585                 590         


Glu Ala Gln Leu Ile Tyr Arg His Leu Leu Gly Val Glu Ala Met Leu 
        595                 600                 605             


Trp Glu Arg His Arg Glu Leu Ser Gly Gly Ala Glu Ala Gly Thr Val 
    610                 615                 620                 


Pro Thr Ser Pro Gly Lys Val Pro Glu Asp Ser Leu Ala Arg Leu Leu 
625                 630                 635                 640 


Arg Val Leu Gln Asp Leu Arg Glu Ala His Ser Ser Ser Pro Ala Gly 
                645                 650                 655     


Ser Pro Pro Ser Glu Pro Asn Cys Leu Leu Glu Leu Gln Thr 
            660                 665                 670 


<210>  123
<211>  1473
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Ala Gly Gly Ala Trp Gly Arg Leu Ala Cys Tyr Leu Glu Phe Leu 
1               5                   10                  15      


Lys Lys Glu Glu Leu Lys Glu Phe Gln Leu Leu Leu Ala Asn Lys Ala 
            20                  25                  30          


His Ser Arg Ser Ser Ser Gly Glu Thr Pro Ala Gln Pro Glu Lys Thr 
        35                  40                  45              


Ser Gly Met Glu Val Ala Ser Tyr Leu Val Ala Gln Tyr Gly Glu Gln 
    50                  55                  60                  


Arg Ala Trp Asp Leu Ala Leu His Thr Trp Glu Gln Met Gly Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Ala Gln Ala Gln Glu Gly Ala Gly His Ser Pro Ser Phe 
                85                  90                  95      


Pro Tyr Ser Pro Ser Glu Pro His Leu Gly Ser Pro Ser Gln Pro Thr 
            100                 105                 110         


Ser Thr Ala Val Leu Met Pro Trp Ile His Glu Leu Pro Ala Gly Cys 
        115                 120                 125             


Thr Gln Gly Ser Glu Arg Arg Val Leu Arg Gln Leu Pro Asp Thr Ser 
    130                 135                 140                 


Gly Arg Arg Trp Arg Glu Ile Ser Ala Ser Leu Leu Tyr Gln Ala Leu 
145                 150                 155                 160 


Pro Ser Ser Pro Asp His Glu Ser Pro Ser Gln Glu Ser Pro Asn Ala 
                165                 170                 175     


Pro Thr Ser Thr Ala Val Leu Gly Ser Trp Gly Ser Pro Pro Gln Pro 
            180                 185                 190         


Ser Leu Ala Pro Arg Glu Gln Glu Ala Pro Gly Thr Gln Trp Pro Leu 
        195                 200                 205             


Asp Glu Thr Ser Gly Ile Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg 
    210                 215                 220                 


Glu Lys Ser Glu Lys Gly Arg Pro Pro Trp Ala Ala Val Val Gly Thr 
225                 230                 235                 240 


Pro Pro Gln Ala His Thr Ser Leu Gln Pro His His His Pro Trp Glu 
                245                 250                 255     


Pro Ser Val Arg Glu Ser Leu Cys Ser Thr Trp Pro Trp Lys Asn Glu 
            260                 265                 270         


Asp Phe Asn Gln Lys Phe Thr Gln Leu Leu Leu Leu Gln Arg Pro His 
        275                 280                 285             


Pro Arg Ser Gln Asp Pro Leu Val Lys Arg Ser Trp Pro Asp Tyr Val 
    290                 295                 300                 


Glu Glu Asn Arg Gly His Leu Ile Glu Ile Arg Asp Leu Phe Gly Pro 
305                 310                 315                 320 


Gly Leu Asp Thr Gln Glu Pro Arg Ile Val Ile Leu Gln Gly Ala Ala 
                325                 330                 335     


Gly Ile Gly Lys Ser Thr Leu Ala Arg Gln Val Lys Glu Ala Trp Gly 
            340                 345                 350         


Arg Gly Gln Leu Tyr Gly Asp Arg Phe Gln His Val Phe Tyr Phe Ser 
        355                 360                 365             


Cys Arg Glu Leu Ala Gln Ser Lys Val Val Ser Leu Ala Glu Leu Ile 
    370                 375                 380                 


Gly Lys Asp Gly Thr Ala Thr Pro Ala Pro Ile Arg Gln Ile Leu Ser 
385                 390                 395                 400 


Arg Pro Glu Arg Leu Leu Phe Ile Leu Asp Gly Val Asp Glu Pro Gly 
                405                 410                 415     


Trp Val Leu Gln Glu Pro Ser Ser Glu Leu Cys Leu His Trp Ser Gln 
            420                 425                 430         


Pro Gln Pro Ala Asp Ala Leu Leu Gly Ser Leu Leu Gly Lys Thr Ile 
        435                 440                 445             


Leu Pro Glu Ala Ser Phe Leu Ile Thr Ala Arg Thr Thr Ala Leu Gln 
    450                 455                 460                 


Asn Leu Ile Pro Ser Leu Glu Gln Ala Arg Trp Val Glu Val Leu Gly 
465                 470                 475                 480 


Phe Ser Glu Ser Ser Arg Lys Glu Tyr Phe Tyr Arg Tyr Phe Thr Asp 
                485                 490                 495     


Glu Arg Gln Ala Ile Arg Ala Phe Arg Leu Val Lys Ser Asn Lys Glu 
            500                 505                 510         


Leu Trp Ala Leu Cys Leu Val Pro Trp Val Ser Trp Leu Ala Cys Thr 
        515                 520                 525             


Cys Leu Met Gln Gln Met Lys Arg Lys Glu Lys Leu Thr Leu Thr Ser 
    530                 535                 540                 


Lys Thr Thr Thr Thr Leu Cys Leu His Tyr Leu Ala Gln Ala Leu Gln 
545                 550                 555                 560 


Ala Gln Pro Leu Gly Pro Gln Leu Arg Asp Leu Cys Ser Leu Ala Ala 
                565                 570                 575     


Glu Gly Ile Trp Gln Lys Lys Thr Leu Phe Ser Pro Asp Asp Leu Arg 
            580                 585                 590         


Lys His Gly Leu Asp Gly Ala Ile Ile Ser Thr Phe Leu Lys Met Gly 
        595                 600                 605             


Ile Leu Gln Glu His Pro Ile Pro Leu Ser Tyr Ser Phe Ile His Leu 
    610                 615                 620                 


Cys Phe Gln Glu Phe Phe Ala Ala Met Ser Tyr Val Leu Glu Asp Glu 
625                 630                 635                 640 


Lys Gly Arg Gly Lys His Ser Asn Cys Ile Ile Asp Leu Glu Lys Thr 
                645                 650                 655     


Leu Glu Ala Tyr Gly Ile His Gly Leu Phe Gly Ala Ser Thr Thr Arg 
            660                 665                 670         


Phe Leu Leu Gly Leu Leu Ser Asp Glu Gly Glu Arg Glu Met Glu Asn 
        675                 680                 685             


Ile Phe His Cys Arg Leu Ser Gln Gly Arg Asn Leu Met Gln Trp Val 
    690                 695                 700                 


Pro Ser Leu Gln Leu Leu Leu Gln Pro His Ser Leu Glu Ser Leu His 
705                 710                 715                 720 


Cys Leu Tyr Glu Thr Arg Asn Lys Thr Phe Leu Thr Gln Val Met Ala 
                725                 730                 735     


His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu Leu Leu 
            740                 745                 750         


Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys Leu Gln 
        755                 760                 765             


Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr Met Val 
    770                 775                 780                 


Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln Ile Leu 
785                 790                 795                 800 


Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp Leu Ser 
                805                 810                 815     


Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys Thr Leu 
            820                 825                 830         


Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly Cys Gly 
        835                 840                 845             


Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg Ala Asn 
    850                 855                 860                 


Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr Asp Ala 
865                 870                 875                 880 


Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys Lys Leu 
                885                 890                 895     


Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys Cys Gln 
            900                 905                 910         


Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu Leu Asp 
        915                 920                 925             


Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu Asp Gln 
945                 950                 955                 960 


Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu Glu Gln 
                965                 970                 975     


Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser Val Met 
            980                 985                 990         


Thr Pro Thr Glu Gly Leu Asp Thr  Gly Glu Met Ser Asn  Ser Thr Ser 
        995                 1000                 1005             


Ser Leu  Lys Arg Gln Arg Leu  Gly Ser Glu Arg Ala  Ala Ser His 
    1010                 1015                 1020             


Val Ala  Gln Ala Asn Leu Lys  Leu Leu Asp Val Ser  Lys Ile Phe 
    1025                 1030                 1035             


Pro Ile  Ala Glu Ile Ala Glu  Glu Ser Ser Pro Glu  Val Val Pro 
    1040                 1045                 1050             


Val Glu  Leu Leu Cys Val Pro  Ser Pro Ala Ser Gln  Gly Asp Leu 
    1055                 1060                 1065             


His Thr  Lys Pro Leu Gly Thr  Asp Asp Asp Phe Trp  Gly Pro Thr 
    1070                 1075                 1080             


Gly Pro  Val Ala Thr Glu Val  Val Asp Lys Glu Lys  Asn Leu Tyr 
    1085                 1090                 1095             


Arg Val  His Phe Pro Val Ala  Gly Ser Tyr Arg Trp  Pro Asn Thr 
    1100                 1105                 1110             


Gly Leu  Cys Phe Val Met Arg  Glu Ala Val Thr Val  Glu Ile Glu 
    1115                 1120                 1125             


Phe Cys  Val Trp Asp Gln Phe  Leu Gly Glu Ile Asn  Pro Gln His 
    1130                 1135                 1140             


Ser Trp  Met Val Ala Gly Pro  Leu Leu Asp Ile Lys  Ala Glu Pro 
    1145                 1150                 1155             


Gly Ala  Val Glu Ala Val His  Leu Pro His Phe Val  Ala Leu Gln 
    1160                 1165                 1170             


Gly Gly  His Val Asp Thr Ser  Leu Phe Gln Met Ala  His Phe Lys 
    1175                 1180                 1185             


Glu Glu  Gly Met Leu Leu Glu  Lys Pro Ala Arg Val  Glu Leu His 
    1190                 1195                 1200             


His Ile  Val Leu Glu Asn Pro  Ser Phe Ser Pro Leu  Gly Val Leu 
    1205                 1210                 1215             


Leu Lys  Met Ile His Asn Ala  Leu Arg Phe Ile Pro  Val Thr Ser 
    1220                 1225                 1230             


Val Val  Leu Leu Tyr His Arg  Val His Pro Glu Glu  Val Thr Phe 
    1235                 1240                 1245             


His Leu  Tyr Leu Ile Pro Ser  Asp Cys Ser Ile Arg  Lys Ala Ile 
    1250                 1255                 1260             


Asp Asp  Leu Glu Met Lys Phe  Gln Phe Val Arg Ile  His Lys Pro 
    1265                 1270                 1275             


Pro Pro  Leu Thr Pro Leu Tyr  Met Gly Cys Arg Tyr  Thr Val Ser 
    1280                 1285                 1290             


Gly Ser  Gly Ser Gly Met Leu  Glu Ile Leu Pro Lys  Glu Leu Glu 
    1295                 1300                 1305             


Leu Cys  Tyr Arg Ser Pro Gly  Glu Asp Gln Leu Phe  Ser Glu Phe 
    1310                 1315                 1320             


Tyr Val  Gly His Leu Gly Ser  Gly Ile Arg Leu Gln  Val Lys Asp 
    1325                 1330                 1335             


Lys Lys  Asp Glu Thr Leu Val  Trp Glu Ala Leu Val  Lys Pro Gly 
    1340                 1345                 1350             


Asp Leu  Met Pro Ala Thr Thr  Leu Ile Pro Pro Ala  Arg Ile Ala 
    1355                 1360                 1365             


Val Pro  Ser Pro Leu Asp Ala  Pro Gln Leu Leu His  Phe Val Asp 
    1370                 1375                 1380             


Gln Tyr  Arg Glu Gln Leu Ile  Ala Arg Val Thr Ser  Val Glu Val 
    1385                 1390                 1395             


Val Leu  Asp Lys Leu His Gly  Gln Val Leu Ser Gln  Glu Gln Tyr 
    1400                 1405                 1410             


Glu Arg  Val Leu Ala Glu Asn  Thr Arg Pro Ser Gln  Met Arg Lys 
    1415                 1420                 1425             


Leu Phe  Ser Leu Ser Gln Ser  Trp Asp Arg Lys Cys  Lys Asp Gly 
    1430                 1435                 1440             


Leu Tyr  Gln Ala Leu Lys Glu  Thr His Pro His Leu  Ile Met Glu 
    1445                 1450                 1455             


Leu Trp  Glu Lys Gly Ser Lys  Lys Gly Leu Leu Pro  Leu Ser Ser 
    1460                 1465                 1470             


<210>  124
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Phe Arg Asn Gln Tyr Asp Asn Asp Val Thr Val Trp Ser Pro Gln 
1               5                   10                  15      


Gly Arg Ile His Gln Ile Glu Tyr Ala Met Glu Ala Val Lys Gln Gly 
            20                  25                  30          


Ser Ala Thr Val Gly Leu Lys Ser Lys Thr His Ala Val Leu Val Ala 
        35                  40                  45              


Leu Lys Arg Ala Gln Ser Glu Leu Ala Ala His Gln Lys Lys Ile Leu 
    50                  55                  60                  


His Val Asp Asn His Ile Gly Ile Ser Ile Ala Gly Leu Thr Ala Asp 
65                  70                  75                  80  


Ala Arg Leu Leu Cys Asn Phe Met Arg Gln Glu Cys Leu Asp Ser Arg 
                85                  90                  95      


Phe Val Phe Asp Arg Pro Leu Pro Val Ser Arg Leu Val Ser Leu Ile 
            100                 105                 110         


Gly Ser Lys Thr Gln Ile Pro Thr Gln Arg Tyr Gly Arg Arg Pro Tyr 
        115                 120                 125             


Gly Val Gly Leu Leu Ile Ala Gly Tyr Asp Asp Met Gly Pro His Ile 
    130                 135                 140                 


Phe Gln Thr Cys Pro Ser Ala Asn Tyr Phe Asp Cys Arg Ala Met Ser 
145                 150                 155                 160 


Ile Gly Ala Arg Ser Gln Ser Ala Arg Thr Tyr Leu Glu Arg His Met 
                165                 170                 175     


Ser Glu Phe Met Glu Cys Asn Leu Asn Glu Leu Val Lys His Gly Leu 
            180                 185                 190         


Arg Ala Leu Arg Glu Thr Leu Pro Ala Glu Gln Asp Leu Thr Thr Lys 
        195                 200                 205             


Asn Val Ser Ile Gly Ile Val Gly Lys Asp Leu Glu Phe Thr Ile Tyr 
    210                 215                 220                 


Asp Asp Asp Asp Val Ser Pro Phe Leu Glu Gly Leu Glu Glu Arg Pro 
225                 230                 235                 240 


Gln Arg Lys Ala Gln Pro Ala Gln Pro Ala Asp Glu Pro Ala Glu Lys 
                245                 250                 255     


Ala Asp Glu Pro Met Glu His 
            260             


<210>  125
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Val Arg Ser Val Ala Trp Ala Gly Phe Met Val Leu Leu Met Ile 
1               5                   10                  15      


Pro Trp Gly Ser Ala Ala Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Gln Gly Glu Ala Arg Phe Leu Pro Lys Asp Leu Asp Pro 
        35                  40                  45              


Ser Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Thr Asn His 
    50                  55                  60                  


Gln Leu Ser Thr Thr Glu Trp Asn Asp Glu Thr Leu Tyr Gln Glu Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Lys Met Asn Pro Lys Leu Lys Thr Leu Leu Ala Ile 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Thr Gln Lys Phe Thr Asp Met Val Ala Thr 
            100                 105                 110         


Ala Asn Asn Arg Gln Thr Phe Val Asn Ser Ala Ile Arg Phe Leu Arg 
        115                 120                 125             


Lys Tyr Ser Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly Ser 
    130                 135                 140                 


Gln Gly Ser Pro Ala Val Asp Lys Glu Arg Phe Thr Thr Leu Val Gln 
145                 150                 155                 160 


Asp Leu Ala Asn Ala Phe Gln Gln Glu Ala Gln Thr Ser Gly Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Ser Ala Ala Val Pro Ala Gly Gln Thr Tyr Val Asp 
            180                 185                 190         


Ala Gly Tyr Glu Val Asp Lys Ile Ala Gln Asn Leu Asp Phe Val Asn 
        195                 200                 205             


Leu Met Ala Tyr Asp Phe His Gly Ser Trp Glu Lys Val Thr Gly His 
    210                 215                 220                 


Asn Ser Pro Leu Tyr Lys Arg Gln Glu Glu Ser Gly Ala Ala Ala Ser 
225                 230                 235                 240 


Leu Asn Val Asp Ala Ala Val Gln Gln Trp Leu Gln Lys Gly Thr Pro 
                245                 250                 255     


Ala Ser Lys Leu Ile Leu Gly Met Pro Thr Tyr Gly Arg Ser Phe Thr 
            260                 265                 270         


Leu Ala Ser Ser Ser Asp Thr Arg Val Gly Ala Pro Ala Thr Gly Ser 
        275                 280                 285             


Gly Thr Pro Gly Pro Phe Thr Lys Glu Gly Gly Met Leu Ala Tyr Tyr 
    290                 295                 300                 


Glu Val Cys Ser Trp Lys Gly Ala Thr Lys Gln Arg Ile Gln Asp Gln 
305                 310                 315                 320 


Lys Val Pro Tyr Ile Phe Arg Asp Asn Gln Trp Val Gly Phe Asp Asp 
                325                 330                 335     


Val Glu Ser Phe Lys Thr Lys Val Ser Tyr Leu Lys Gln Lys Gly Leu 
            340                 345                 350         


Gly Gly Ala Met Val Trp Ala Leu Asp Leu Asp Asp Phe Ala Gly Phe 
        355                 360                 365             


Ser Cys Asn Gln Gly Arg Tyr Pro Leu Ile Gln Thr Leu Arg Gln Glu 
    370                 375                 380                 


Leu Ser Leu Pro Tyr Leu Pro Ser Gly Thr Pro Glu Leu Glu Val Pro 
385                 390                 395                 400 


Lys Pro Gly Gln Pro Ser Glu Pro Glu His Gly Pro Ser Pro Gly Gln 
                405                 410                 415     


Asp Thr Phe Cys Gln Gly Lys Ala Asp Gly Leu Tyr Pro Asn Pro Arg 
            420                 425                 430         


Glu Arg Ser Ser Phe Tyr Ser Cys Ala Ala Gly Arg Leu Phe Gln Gln 
        435                 440                 445             


Ser Cys Pro Thr Gly Leu Val Phe Ser Asn Ser Cys Lys Cys Cys Thr 
    450                 455                 460                 


Trp Asn 
465     


<210>  126
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         


<210>  127
<211>  3259
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Leu Ser Arg Leu Ser Gly Leu Ala Asn Val Val Leu His Glu Leu 
1               5                   10                  15      


Ser Gly Asp Asp Asp Thr Asp Gln Asn Met Arg Ala Pro Leu Asp Pro 
            20                  25                  30          


Glu Leu His Gln Glu Ser Asp Met Glu Phe Asn Asn Thr Thr Gln Glu 
        35                  40                  45              


Asp Val Gln Glu Arg Leu Ala Tyr Ala Glu Gln Leu Val Val Glu Leu 
    50                  55                  60                  


Lys Asp Ile Ile Arg Gln Lys Asp Val Gln Leu Gln Gln Lys Asp Glu 
65                  70                  75                  80  


Ala Leu Gln Glu Glu Arg Lys Ala Ala Asp Asn Lys Ile Lys Lys Leu 
                85                  90                  95      


Lys Leu His Ala Lys Ala Lys Leu Thr Ser Leu Asn Lys Tyr Ile Glu 
            100                 105                 110         


Glu Met Lys Ala Gln Gly Gly Thr Val Leu Pro Thr Glu Pro Gln Ser 
        115                 120                 125             


Glu Glu Gln Leu Ser Lys His Asp Lys Ser Ser Thr Glu Glu Glu Met 
    130                 135                 140                 


Glu Ile Glu Lys Ile Lys His Lys Leu Gln Glu Lys Glu Glu Leu Ile 
145                 150                 155                 160 


Ser Thr Leu Gln Ala Gln Leu Thr Gln Ala Gln Ala Glu Gln Pro Ala 
                165                 170                 175     


Gln Ser Ser Thr Glu Met Glu Glu Phe Val Met Met Lys Gln Gln Leu 
            180                 185                 190         


Gln Glu Lys Glu Glu Phe Ile Ser Thr Leu Gln Ala Gln Leu Ser Gln 
        195                 200                 205             


Thr Gln Ala Glu Gln Ala Ala Gln Gln Val Val Arg Glu Lys Asp Ala 
    210                 215                 220                 


Arg Phe Glu Thr Gln Val Arg Leu His Glu Asp Glu Leu Leu Gln Leu 
225                 230                 235                 240 


Val Thr Gln Ala Asp Val Glu Thr Glu Met Gln Gln Lys Leu Arg Val 
                245                 250                 255     


Leu Gln Arg Lys Leu Glu Glu His Glu Glu Ser Leu Val Gly Arg Ala 
            260                 265                 270         


Gln Val Val Asp Leu Leu Gln Gln Glu Leu Thr Ala Ala Glu Gln Arg 
        275                 280                 285             


Asn Gln Ile Leu Ser Gln Gln Leu Gln Gln Met Glu Ala Glu His Asn 
    290                 295                 300                 


Thr Leu Arg Asn Thr Val Glu Thr Glu Arg Glu Glu Ser Lys Ile Leu 
305                 310                 315                 320 


Leu Glu Lys Met Glu Leu Glu Val Ala Glu Arg Lys Leu Ser Phe His 
                325                 330                 335     


Asn Leu Gln Glu Glu Met His His Leu Leu Glu Gln Phe Glu Gln Ala 
            340                 345                 350         


Gly Gln Ala Gln Ala Glu Leu Glu Ser Arg Tyr Ser Ala Leu Glu Gln 
        355                 360                 365             


Lys His Lys Ala Glu Met Glu Glu Lys Thr Ser His Ile Leu Ser Leu 
    370                 375                 380                 


Gln Lys Thr Gly Gln Glu Leu Gln Ser Ala Cys Asp Ala Leu Lys Asp 
385                 390                 395                 400 


Gln Asn Ser Lys Leu Leu Gln Asp Lys Asn Glu Gln Ala Val Gln Ser 
                405                 410                 415     


Ala Gln Thr Ile Gln Gln Leu Glu Asp Gln Leu Gln Gln Lys Ser Lys 
            420                 425                 430         


Glu Ile Ser Gln Phe Leu Asn Arg Leu Pro Leu Gln Gln His Glu Thr 
        435                 440                 445             


Ala Ser Gln Thr Ser Phe Pro Asp Val Tyr Asn Glu Gly Thr Gln Ala 
    450                 455                 460                 


Val Thr Glu Glu Asn Ile Ala Ser Leu Gln Lys Arg Val Val Glu Leu 
465                 470                 475                 480 


Glu Asn Glu Lys Gly Ala Leu Leu Leu Ser Ser Ile Glu Leu Glu Glu 
                485                 490                 495     


Leu Lys Ala Glu Asn Glu Lys Leu Ser Ser Gln Ile Thr Leu Leu Glu 
            500                 505                 510         


Ala Gln Asn Arg Thr Gly Glu Ala Asp Arg Glu Val Ser Glu Ile Ser 
        515                 520                 525             


Ile Val Asp Ile Ala Asn Lys Arg Ser Ser Ser Ala Glu Glu Ser Gly 
    530                 535                 540                 


Gln Asp Val Leu Glu Asn Thr Phe Ser Gln Lys His Lys Glu Leu Ser 
545                 550                 555                 560 


Val Leu Leu Leu Glu Met Lys Glu Ala Gln Glu Glu Ile Ala Phe Leu 
                565                 570                 575     


Lys Leu Gln Leu Gln Gly Lys Arg Ala Glu Glu Ala Asp His Glu Val 
            580                 585                 590         


Leu Asp Gln Lys Glu Met Lys Gln Met Glu Gly Glu Gly Ile Ala Pro 
        595                 600                 605             


Ile Lys Met Lys Val Phe Leu Glu Asp Thr Gly Gln Asp Phe Pro Leu 
    610                 615                 620                 


Met Pro Asn Glu Glu Ser Ser Leu Pro Ala Val Glu Lys Glu Gln Ala 
625                 630                 635                 640 


Ser Thr Glu His Gln Ser Arg Thr Ser Glu Glu Ile Ser Leu Asn Asp 
                645                 650                 655     


Ala Gly Val Glu Leu Lys Ser Thr Lys Gln Asp Gly Asp Lys Ser Leu 
            660                 665                 670         


Ser Ala Val Pro Asp Ile Gly Gln Cys His Gln Asp Glu Leu Glu Arg 
        675                 680                 685             


Leu Lys Ser Gln Ile Leu Glu Leu Glu Leu Asn Phe His Lys Ala Gln 
    690                 695                 700                 


Glu Ile Tyr Glu Lys Asn Leu Asp Glu Lys Ala Lys Glu Ile Ser Asn 
705                 710                 715                 720 


Leu Asn Gln Leu Ile Glu Glu Phe Lys Lys Asn Ala Asp Asn Asn Ser 
                725                 730                 735     


Ser Ala Phe Thr Ala Leu Ser Glu Glu Arg Asp Gln Leu Leu Ser Gln 
            740                 745                 750         


Val Lys Glu Leu Ser Met Val Thr Glu Leu Arg Ala Gln Val Lys Gln 
        755                 760                 765             


Leu Glu Met Asn Leu Ala Glu Ala Glu Arg Gln Arg Arg Leu Asp Tyr 
    770                 775                 780                 


Glu Ser Gln Thr Ala His Asp Asn Leu Leu Thr Glu Gln Ile His Ser 
785                 790                 795                 800 


Leu Ser Ile Glu Ala Lys Ser Lys Asp Val Lys Ile Glu Val Leu Gln 
                805                 810                 815     


Asn Glu Leu Asp Asp Val Gln Leu Gln Phe Ser Glu Gln Ser Thr Leu 
            820                 825                 830         


Ile Arg Ser Leu Gln Ser Gln Leu Gln Asn Lys Glu Ser Glu Val Leu 
        835                 840                 845             


Glu Gly Ala Glu Arg Val Arg His Ile Ser Ser Lys Val Glu Glu Leu 
    850                 855                 860                 


Ser Gln Ala Leu Ser Gln Lys Glu Leu Glu Ile Thr Lys Met Asp Gln 
865                 870                 875                 880 


Leu Leu Leu Glu Lys Lys Arg Asp Val Glu Thr Leu Gln Gln Thr Ile 
                885                 890                 895     


Glu Glu Lys Asp Gln Gln Val Thr Glu Ile Ser Phe Ser Met Thr Glu 
            900                 905                 910         


Lys Met Val Gln Leu Asn Glu Glu Lys Phe Ser Leu Gly Val Glu Ile 
        915                 920                 925             


Lys Thr Leu Lys Glu Gln Leu Asn Leu Leu Ser Arg Ala Glu Glu Ala 
    930                 935                 940                 


Lys Lys Glu Gln Val Glu Glu Asp Asn Glu Val Ser Ser Gly Leu Lys 
945                 950                 955                 960 


Gln Asn Tyr Asp Glu Met Ser Pro Ala Gly Gln Ile Ser Lys Glu Glu 
                965                 970                 975     


Leu Gln His Glu Phe Asp Leu Leu Lys Lys Glu Asn Glu Gln Arg Lys 
            980                 985                 990         


Arg Lys Leu Gln Ala Ala Leu Ile  Asn Arg Lys Glu Leu  Leu Gln Arg 
        995                 1000                 1005             


Val Ser  Arg Leu Glu Glu Glu  Leu Ala Asn Leu Lys  Asp Glu Ser 
    1010                 1015                 1020             


Lys Lys  Glu Ile Pro Leu Ser  Glu Thr Glu Arg Gly  Glu Val Glu 
    1025                 1030                 1035             


Glu Asp  Lys Glu Asn Lys Glu  Tyr Ser Glu Lys Cys  Val Thr Ser 
    1040                 1045                 1050             


Lys Cys  Gln Glu Ile Glu Ile  Tyr Leu Lys Gln Thr  Ile Ser Glu 
    1055                 1060                 1065             


Lys Glu  Val Glu Leu Gln His  Ile Arg Lys Asp Leu  Glu Glu Lys 
    1070                 1075                 1080             


Leu Ala  Ala Glu Glu Gln Phe  Gln Ala Leu Val Lys  Gln Met Asn 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asp Lys Thr  Asn Gln Ile Asp Leu  Leu Gln Ala 
    1100                 1105                 1110             


Glu Ile  Ser Glu Asn Gln Ala  Ile Ile Gln Lys Leu  Ile Thr Ser 
    1115                 1120                 1125             


Asn Thr  Asp Ala Ser Asp Gly  Asp Ser Val Ala Leu  Val Lys Glu 
    1130                 1135                 1140             


Thr Val  Val Ile Ser Pro Pro  Cys Thr Gly Ser Ser  Glu His Trp 
    1145                 1150                 1155             


Lys Pro  Glu Leu Glu Glu Lys  Ile Leu Ala Leu Glu  Lys Glu Lys 
    1160                 1165                 1170             


Glu Gln  Leu Gln Lys Lys Leu  Gln Glu Ala Leu Thr  Ser Arg Lys 
    1175                 1180                 1185             


Ala Ile  Leu Lys Lys Ala Gln  Glu Lys Glu Arg His  Leu Arg Glu 
    1190                 1195                 1200             


Glu Leu  Lys Gln Gln Lys Asp  Asp Tyr Asn Arg Leu  Gln Glu Gln 
    1205                 1210                 1215             


Phe Asp  Glu Gln Ser Lys Glu  Asn Glu Asn Ile Gly  Asp Gln Leu 
    1220                 1225                 1230             


Arg Gln  Leu Gln Ile Gln Val  Arg Glu Ser Ile Asp  Gly Lys Leu 
    1235                 1240                 1245             


Pro Ser  Thr Asp Gln Gln Glu  Ser Cys Ser Ser Thr  Pro Gly Leu 
    1250                 1255                 1260             


Glu Glu  Pro Leu Phe Lys Ala  Thr Glu Gln His His  Thr Gln Pro 
    1265                 1270                 1275             


Val Leu  Glu Ser Asn Leu Cys  Pro Asp Trp Pro Ser  His Ser Glu 
    1280                 1285                 1290             


Asp Ala  Ser Ala Leu Gln Gly  Gly Thr Ser Val Ala  Gln Ile Lys 
    1295                 1300                 1305             


Ala Gln  Leu Lys Glu Ile Glu  Ala Glu Lys Val Glu  Leu Glu Leu 
    1310                 1315                 1320             


Lys Val  Ser Ser Thr Thr Ser  Glu Leu Thr Lys Lys  Ser Glu Glu 
    1325                 1330                 1335             


Val Phe  Gln Leu Gln Glu Gln  Ile Asn Lys Gln Gly  Leu Glu Ile 
    1340                 1345                 1350             


Glu Ser  Leu Lys Thr Val Ser  His Glu Ala Glu Val  His Ala Glu 
    1355                 1360                 1365             


Ser Leu  Gln Gln Lys Leu Glu  Ser Ser Gln Leu Gln  Ile Ala Gly 
    1370                 1375                 1380             


Leu Glu  His Leu Arg Glu Leu  Gln Pro Lys Leu Asp  Glu Leu Gln 
    1385                 1390                 1395             


Lys Leu  Ile Ser Lys Lys Glu  Glu Asp Val Ser Tyr  Leu Ser Gly 
    1400                 1405                 1410             


Gln Leu  Ser Glu Lys Glu Ala  Ala Leu Thr Lys Ile  Gln Thr Glu 
    1415                 1420                 1425             


Ile Ile  Glu Gln Glu Asp Leu  Ile Lys Ala Leu His  Thr Gln Leu 
    1430                 1435                 1440             


Glu Met  Gln Ala Lys Glu His  Asp Glu Arg Ile Lys  Gln Leu Gln 
    1445                 1450                 1455             


Val Glu  Leu Cys Glu Met Lys  Gln Lys Pro Glu Glu  Ile Gly Glu 
    1460                 1465                 1470             


Glu Ser  Arg Ala Lys Gln Gln  Ile Gln Arg Lys Leu  Gln Ala Ala 
    1475                 1480                 1485             


Leu Ile  Ser Arg Lys Glu Ala  Leu Lys Glu Asn Lys  Ser Leu Gln 
    1490                 1495                 1500             


Glu Glu  Leu Ser Leu Ala Arg  Gly Thr Ile Glu Arg  Leu Thr Lys 
    1505                 1510                 1515             


Ser Leu  Ala Asp Val Glu Ser  Gln Val Ser Ala Gln  Asn Lys Glu 
    1520                 1525                 1530             


Lys Asp  Thr Val Leu Gly Arg  Leu Ala Leu Leu Gln  Glu Glu Arg 
    1535                 1540                 1545             


Asp Lys  Leu Ile Thr Glu Met  Asp Arg Ser Leu Leu  Glu Asn Gln 
    1550                 1555                 1560             


Ser Leu  Ser Ser Ser Cys Glu  Ser Leu Lys Leu Ala  Leu Glu Gly 
    1565                 1570                 1575             


Leu Thr  Glu Asp Lys Glu Lys  Leu Val Lys Glu Ile  Glu Ser Leu 
    1580                 1585                 1590             


Lys Ser  Ser Lys Ile Ala Glu  Ser Thr Glu Trp Gln  Glu Lys His 
    1595                 1600                 1605             


Lys Glu  Leu Gln Lys Glu Tyr  Glu Ile Leu Leu Gln  Ser Tyr Glu 
    1610                 1615                 1620             


Asn Val  Ser Asn Glu Ala Glu  Arg Ile Gln His Val  Val Glu Ala 
    1625                 1630                 1635             


Val Arg  Gln Glu Lys Gln Glu  Leu Tyr Gly Lys Leu  Arg Ser Thr 
    1640                 1645                 1650             


Glu Ala  Asn Lys Lys Glu Thr  Glu Lys Gln Leu Gln  Glu Ala Glu 
    1655                 1660                 1665             


Gln Glu  Met Glu Glu Met Lys  Glu Lys Met Arg Lys  Phe Ala Lys 
    1670                 1675                 1680             


Ser Lys  Gln Gln Lys Ile Leu  Glu Leu Glu Glu Glu  Asn Asp Arg 
    1685                 1690                 1695             


Leu Arg  Ala Glu Val His Pro  Ala Gly Asp Thr Ala  Lys Glu Cys 
    1700                 1705                 1710             


Met Glu  Thr Leu Leu Ser Ser  Asn Ala Ser Met Lys  Glu Glu Leu 
    1715                 1720                 1725             


Glu Arg  Val Lys Met Glu Tyr  Glu Thr Leu Ser Lys  Lys Phe Gln 
    1730                 1735                 1740             


Ser Leu  Met Ser Glu Lys Asp  Ser Leu Ser Glu Glu  Val Gln Asp 
    1745                 1750                 1755             


Leu Lys  His Gln Ile Glu Gly  Asn Val Ser Lys Gln  Ala Asn Leu 
    1760                 1765                 1770             


Glu Ala  Thr Glu Lys His Asp  Asn Gln Thr Asn Val  Thr Glu Glu 
    1775                 1780                 1785             


Gly Thr  Gln Ser Ile Pro Gly  Glu Thr Glu Glu Gln  Asp Ser Leu 
    1790                 1795                 1800             


Ser Met  Ser Thr Arg Pro Thr  Cys Ser Glu Ser Val  Pro Ser Ala 
    1805                 1810                 1815             


Lys Ser  Ala Asn Pro Ala Val  Ser Lys Asp Phe Ser  Ser His Asp 
    1820                 1825                 1830             


Glu Ile  Asn Asn Tyr Leu Gln  Gln Ile Asp Gln Leu  Lys Glu Arg 
    1835                 1840                 1845             


Ile Ala  Gly Leu Glu Glu Glu  Lys Gln Lys Asn Lys  Glu Phe Ser 
    1850                 1855                 1860             


Gln Thr  Leu Glu Asn Glu Lys  Asn Thr Leu Leu Ser  Gln Ile Ser 
    1865                 1870                 1875             


Thr Lys  Asp Gly Glu Leu Lys  Met Leu Gln Glu Glu  Val Thr Lys 
    1880                 1885                 1890             


Met Asn  Leu Leu Asn Gln Gln  Ile Gln Glu Glu Leu  Ser Arg Val 
    1895                 1900                 1905             


Thr Lys  Leu Lys Glu Thr Ala  Glu Glu Glu Lys Asp  Asp Leu Glu 
    1910                 1915                 1920             


Glu Arg  Leu Met Asn Gln Leu  Ala Glu Leu Asn Gly  Ser Ile Gly 
    1925                 1930                 1935             


Asn Tyr  Cys Gln Asp Val Thr  Asp Ala Gln Ile Lys  Asn Glu Leu 
    1940                 1945                 1950             


Leu Glu  Ser Glu Met Lys Asn  Leu Lys Lys Cys Val  Ser Glu Leu 
    1955                 1960                 1965             


Glu Glu  Glu Lys Gln Gln Leu  Val Lys Glu Lys Thr  Lys Val Glu 
    1970                 1975                 1980             


Ser Glu  Ile Arg Lys Glu Tyr  Leu Glu Lys Ile Gln  Gly Ala Gln 
    1985                 1990                 1995             


Lys Glu  Pro Gly Asn Lys Ser  His Ala Lys Glu Leu  Gln Glu Leu 
    2000                 2005                 2010             


Leu Lys  Glu Lys Gln Gln Glu  Val Lys Gln Leu Gln  Lys Asp Cys 
    2015                 2020                 2025             


Ile Arg  Tyr Gln Glu Lys Ile  Ser Ala Leu Glu Arg  Thr Val Lys 
    2030                 2035                 2040             


Ala Leu  Glu Phe Val Gln Thr  Glu Ser Gln Lys Asp  Leu Glu Ile 
    2045                 2050                 2055             


Thr Lys  Glu Asn Leu Ala Gln  Ala Val Glu His Arg  Lys Lys Ala 
    2060                 2065                 2070             


Gln Ala  Glu Leu Ala Ser Phe  Lys Val Leu Leu Asp  Asp Thr Gln 
    2075                 2080                 2085             


Ser Glu  Ala Ala Arg Val Leu  Ala Asp Asn Leu Lys  Leu Lys Lys 
    2090                 2095                 2100             


Glu Leu  Gln Ser Asn Lys Glu  Ser Val Lys Ser Gln  Met Lys Gln 
    2105                 2110                 2115             


Lys Asp  Glu Asp Leu Glu Arg  Arg Leu Glu Gln Ala  Glu Glu Lys 
    2120                 2125                 2130             


His Leu  Lys Glu Lys Lys Asn  Met Gln Glu Lys Leu  Asp Ala Leu 
    2135                 2140                 2145             


Arg Arg  Glu Lys Val His Leu  Glu Glu Thr Ile Gly  Glu Ile Gln 
    2150                 2155                 2160             


Val Thr  Leu Asn Lys Lys Asp  Lys Glu Val Gln Gln  Leu Gln Glu 
    2165                 2170                 2175             


Asn Leu  Asp Ser Thr Val Thr  Gln Leu Ala Ala Phe  Thr Lys Ser 
    2180                 2185                 2190             


Met Ser  Ser Leu Gln Asp Asp  Arg Asp Arg Val Ile  Asp Glu Ala 
    2195                 2200                 2205             


Lys Lys  Trp Glu Arg Lys Phe  Ser Asp Ala Ile Gln  Ser Lys Glu 
    2210                 2215                 2220             


Glu Glu  Ile Arg Leu Lys Glu  Asp Asn Cys Ser Val  Leu Lys Asp 
    2225                 2230                 2235             


Gln Leu  Arg Gln Met Ser Ile  His Met Glu Glu Leu  Lys Ile Asn 
    2240                 2245                 2250             


Ile Ser  Arg Leu Glu His Asp  Lys Gln Ile Trp Glu  Ser Lys Ala 
    2255                 2260                 2265             


Gln Thr  Glu Val Gln Leu Gln  Gln Lys Val Cys Asp  Thr Leu Gln 
    2270                 2275                 2280             


Gly Glu  Asn Lys Glu Leu Leu  Ser Gln Leu Glu Glu  Thr Arg His 
    2285                 2290                 2295             


Leu Tyr  His Ser Ser Gln Asn  Glu Leu Ala Lys Leu  Glu Ser Glu 
    2300                 2305                 2310             


Leu Lys  Ser Leu Lys Asp Gln  Leu Thr Asp Leu Ser  Asn Ser Leu 
    2315                 2320                 2325             


Glu Lys  Cys Lys Glu Gln Lys  Gly Asn Leu Glu Gly  Ile Ile Arg 
    2330                 2335                 2340             


Gln Gln  Glu Ala Asp Ile Gln  Asn Ser Lys Phe Ser  Tyr Glu Gln 
    2345                 2350                 2355             


Leu Glu  Thr Asp Leu Gln Ala  Ser Arg Glu Leu Thr  Ser Arg Leu 
    2360                 2365                 2370             


His Glu  Glu Ile Asn Met Lys  Glu Gln Lys Ile Ile  Ser Leu Leu 
    2375                 2380                 2385             


Ser Gly  Lys Glu Glu Ala Ile  Gln Val Ala Ile Ala  Glu Leu Arg 
    2390                 2395                 2400             


Gln Gln  His Asp Lys Glu Ile  Lys Glu Leu Glu Asn  Leu Leu Ser 
    2405                 2410                 2415             


Gln Glu  Glu Glu Glu Asn Ile  Val Leu Glu Glu Glu  Asn Lys Lys 
    2420                 2425                 2430             


Ala Val  Asp Lys Thr Asn Gln  Leu Met Glu Thr Leu  Lys Thr Ile 
    2435                 2440                 2445             


Lys Lys  Glu Asn Ile Gln Gln  Lys Ala Gln Leu Asp  Ser Phe Val 
    2450                 2455                 2460             


Lys Ser  Met Ser Ser Leu Gln  Asn Asp Arg Asp Arg  Ile Val Gly 
    2465                 2470                 2475             


Asp Tyr  Gln Gln Leu Glu Glu  Arg His Leu Ser Ile  Ile Leu Glu 
    2480                 2485                 2490             


Lys Asp  Gln Leu Ile Gln Glu  Ala Ala Ala Glu Asn  Asn Lys Leu 
    2495                 2500                 2505             


Lys Glu  Glu Ile Arg Gly Leu  Arg Ser His Met Asp  Asp Leu Asn 
    2510                 2515                 2520             


Ser Glu  Asn Ala Lys Leu Asp  Ala Glu Leu Ile Gln  Tyr Arg Glu 
    2525                 2530                 2535             


Asp Leu  Asn Gln Val Ile Thr  Ile Lys Asp Ser Gln  Gln Lys Gln 
    2540                 2545                 2550             


Leu Leu  Glu Val Gln Leu Gln  Gln Asn Lys Glu Leu  Glu Asn Lys 
    2555                 2560                 2565             


Tyr Ala  Lys Leu Glu Glu Lys  Leu Lys Glu Ser Glu  Glu Ala Asn 
    2570                 2575                 2580             


Glu Asp  Leu Arg Arg Ser Phe  Asn Ala Leu Gln Glu  Glu Lys Gln 
    2585                 2590                 2595             


Asp Leu  Ser Lys Glu Ile Glu  Ser Leu Lys Val Ser  Ile Ser Gln 
    2600                 2605                 2610             


Leu Thr  Arg Gln Val Thr Ala  Leu Gln Glu Glu Gly  Thr Leu Gly 
    2615                 2620                 2625             


Leu Tyr  His Ala Gln Leu Lys  Val Lys Glu Glu Glu  Val His Arg 
    2630                 2635                 2640             


Leu Ser  Ala Leu Phe Ser Ser  Ser Gln Lys Arg Ile  Ala Glu Leu 
    2645                 2650                 2655             


Glu Glu  Glu Leu Val Cys Val  Gln Lys Glu Ala Ala  Lys Lys Val 
    2660                 2665                 2670             


Gly Glu  Ile Glu Asp Lys Leu  Lys Lys Glu Leu Lys  His Leu His 
    2675                 2680                 2685             


His Asp  Ala Gly Ile Met Arg  Asn Glu Thr Glu Thr  Ala Glu Glu 
    2690                 2695                 2700             


Arg Val  Ala Glu Leu Ala Arg  Asp Leu Val Glu Met  Glu Gln Lys 
    2705                 2710                 2715             


Leu Leu  Met Val Thr Lys Glu  Asn Lys Gly Leu Thr  Ala Gln Ile 
    2720                 2725                 2730             


Gln Ser  Phe Gly Arg Ser Met  Ser Ser Leu Gln Asn  Ser Arg Asp 
    2735                 2740                 2745             


His Ala  Asn Glu Glu Leu Asp  Glu Leu Lys Arg Lys  Tyr Asp Ala 
    2750                 2755                 2760             


Ser Leu  Lys Glu Leu Ala Gln  Leu Lys Glu Gln Gly  Leu Leu Asn 
    2765                 2770                 2775             


Arg Glu  Arg Asp Ala Leu Leu  Ser Glu Thr Ala Phe  Ser Met Asn 
    2780                 2785                 2790             


Ser Thr  Glu Glu Asn Ser Leu  Ser His Leu Glu Lys  Leu Asn Gln 
    2795                 2800                 2805             


Gln Leu  Leu Ser Lys Asp Glu  Gln Leu Leu His Leu  Ser Ser Gln 
    2810                 2815                 2820             


Leu Glu  Asp Ser Tyr Asn Gln  Val Gln Ser Phe Ser  Lys Ala Met 
    2825                 2830                 2835             


Ala Ser  Leu Gln Asn Glu Arg  Asp His Leu Trp Asn  Glu Leu Glu 
    2840                 2845                 2850             


Lys Phe  Arg Lys Ser Glu Glu  Gly Lys Gln Arg Ser  Ala Ala Gln 
    2855                 2860                 2865             


Pro Ser  Thr Ser Pro Ala Glu  Val Gln Ser Leu Lys  Lys Ala Met 
    2870                 2875                 2880             


Ser Ser  Leu Gln Asn Asp Arg  Asp Arg Leu Leu Lys  Glu Leu Lys 
    2885                 2890                 2895             


Asn Leu  Gln Gln Gln Tyr Leu  Gln Ile Asn Gln Glu  Ile Thr Glu 
    2900                 2905                 2910             


Leu His  Pro Leu Lys Ala Gln  Leu Gln Glu Tyr Gln  Asp Lys Thr 
    2915                 2920                 2925             


Lys Ala  Phe Gln Ile Met Gln  Glu Glu Leu Arg Gln  Glu Asn Leu 
    2930                 2935                 2940             


Ser Trp  Gln His Glu Leu His  Gln Leu Arg Met Glu  Lys Ser Ser 
    2945                 2950                 2955             


Trp Glu  Ile His Glu Arg Arg  Met Lys Glu Gln Tyr  Leu Met Ala 
    2960                 2965                 2970             


Ile Ser  Asp Lys Asp Gln Gln  Leu Ser His Leu Gln  Asn Leu Ile 
    2975                 2980                 2985             


Arg Glu  Leu Arg Ser Ser Ser  Ser Gln Thr Gln Pro  Leu Lys Val 
    2990                 2995                 3000             


Gln Tyr  Gln Arg Gln Ala Ser  Pro Glu Thr Ser Ala  Ser Pro Asp 
    3005                 3010                 3015             


Gly Ser  Gln Asn Leu Val Tyr  Glu Thr Glu Leu Leu  Arg Thr Gln 
    3020                 3025                 3030             


Leu Asn  Asp Ser Leu Lys Glu  Ile His Gln Lys Glu  Leu Arg Ile 
    3035                 3040                 3045             


Gln Gln  Leu Asn Ser Asn Phe  Ser Gln Leu Leu Glu  Glu Lys Asn 
    3050                 3055                 3060             


Thr Leu  Ser Ile Gln Leu Cys  Asp Thr Ser Gln Ser  Leu Arg Glu 
    3065                 3070                 3075             


Asn Gln  Gln His Tyr Gly Asp  Leu Leu Asn His Cys  Ala Val Leu 
    3080                 3085                 3090             


Glu Lys  Gln Val Gln Glu Leu  Gln Ala Gly Pro Leu  Asn Ile Asp 
    3095                 3100                 3105             


Val Ala  Pro Gly Ala Pro Gln  Glu Lys Asn Gly Val  His Arg Lys 
    3110                 3115                 3120             


Ser Asp  Pro Glu Glu Leu Arg  Glu Pro Gln Gln Ser  Phe Ser Glu 
    3125                 3130                 3135             


Ala Gln  Gln Gln Leu Cys Asn  Thr Arg Gln Glu Val  Asn Glu Leu 
    3140                 3145                 3150             


Arg Lys  Leu Leu Glu Glu Glu  Arg Asp Gln Arg Val  Ala Ala Glu 
    3155                 3160                 3165             


Asn Ala  Leu Ser Val Ala Glu  Glu Gln Ile Arg Arg  Leu Glu His 
    3170                 3175                 3180             


Ser Glu  Trp Asp Ser Ser Arg  Thr Pro Ile Ile Gly  Ser Cys Gly 
    3185                 3190                 3195             


Thr Gln  Glu Gln Ala Leu Leu  Ile Asp Leu Thr Ser  Asn Ser Cys 
    3200                 3205                 3210             


Arg Arg  Thr Arg Ser Gly Val  Gly Trp Lys Arg Val  Leu Arg Ser 
    3215                 3220                 3225             


Leu Cys  His Ser Arg Thr Arg  Val Pro Leu Leu Ala  Ala Ile Tyr 
    3230                 3235                 3240             


Phe Leu  Met Ile His Val Leu  Leu Ile Leu Cys Phe  Thr Gly His 
    3245                 3250                 3255             


Leu 
    


<210>  128
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Ala Leu Arg Gly Thr Leu Arg Pro Leu Lys Val Arg Arg Arg Arg 
1               5                   10                  15      


Glu Met Leu Pro Gln Gln Val Gly Phe Val Cys Ala Val Leu Ala Leu 
            20                  25                  30          


Val Cys Cys Ala Ser Gly Leu Phe Gly Ser Leu Gly His Lys Thr Ala 
        35                  40                  45              


Ser Ala Ser Lys Arg Val Leu Pro Asp Thr Trp Arg Asn Arg Lys Leu 
    50                  55                  60                  


Met Ala Pro Val Asn Gly Thr Gln Thr Ala Lys Asn Cys Thr Asp Pro 
65                  70                  75                  80  


Ala Ile His Glu Phe Pro Thr Asp Leu Phe Ser Asn Lys Glu Arg Gln 
                85                  90                  95      


His Gly Ala Val Leu Leu His Ile Leu Gly Ala Leu Tyr Met Phe Tyr 
            100                 105                 110         


Ala Leu Ala Ile Val Cys Asp Asp Phe Phe Val Pro Ser Leu Glu Lys 
        115                 120                 125             


Ile Cys Glu Arg Leu His Leu Ser Glu Asp Val Ala Gly Ala Thr Phe 
    130                 135                 140                 


Met Ala Ala Gly Ser Ser Thr Pro Glu Leu Phe Ala Ser Val Ile Gly 
145                 150                 155                 160 


Val Phe Ile Thr His Gly Asp Val Gly Val Gly Thr Ile Val Gly Ser 
                165                 170                 175     


Ala Val Phe Asn Ile Leu Cys Ile Ile Gly Val Cys Gly Leu Phe Ala 
            180                 185                 190         


Gly Gln Val Val Arg Leu Thr Trp Trp Ala Val Cys Arg Asp Ser Val 
        195                 200                 205             


Tyr Tyr Thr Ile Ser Val Ile Val Leu Ile Val Phe Ile Tyr Asp Glu 
    210                 215                 220                 


Gln Ile Val Trp Trp Glu Gly Leu Val Leu Ile Ile Leu Tyr Val Phe 
225                 230                 235                 240 


Tyr Ile Leu Ile Met Lys Tyr Asn Val Lys Met Gln Ala Phe Phe Thr 
                245                 250                 255     


Val Lys Gln Lys Ser Ile Ala Asn Gly Asn Pro Val Asn Ser Glu Leu 
            260                 265                 270         


Glu Ala Gly Asn Asp Phe Tyr Asp Gly Ser Tyr Asp Asp Pro Ser Val 
        275                 280                 285             


Pro Leu Leu Gly Gln Val Lys Glu Lys Pro Gln Tyr Gly Lys Asn Pro 
    290                 295                 300                 


Val Val Met Val Asp Glu Ile Met Ser Ser Ser Pro Pro Lys Phe Thr 
305                 310                 315                 320 


Phe Pro Glu Ala Gly Leu Arg Ile Met Ile Thr Asn Lys Phe Gly Pro 
                325                 330                 335     


Arg Thr Arg Leu Arg Met Ala Ser Arg Ile Ile Ile Asn Glu Arg Gln 
            340                 345                 350         


Arg Leu Ile Asn Ser Ala Asn Gly Val Ser Ser Lys Pro Leu Gln Asn 
        355                 360                 365             


Gly Arg His Glu Asn Ile Glu Asn Gly Asn Val Pro Val Glu Asn Pro 
    370                 375                 380                 


Glu Asp Pro Gln Gln Asn Gln Glu Gln Gln Pro Pro Pro Gln Pro Pro 
385                 390                 395                 400 


Pro Pro Glu Pro Glu Pro Val Glu Ala Asp Phe Leu Ser Pro Phe Ser 
                405                 410                 415     


Val Pro Glu Ala Arg Gly Asp Lys Val Lys Trp Val Phe Thr Trp Pro 
            420                 425                 430         


Leu Ile Phe Leu Leu Cys Val Thr Ile Pro Asn Cys Ser Lys Pro Arg 
        435                 440                 445             


Trp Glu Lys Phe Phe Met Val Thr Phe Ile Thr Ala Thr Leu Trp Ile 
    450                 455                 460                 


Ala Val Phe Ser Tyr Ile Met Val Trp Leu Val Thr Ile Ile Gly Tyr 
465                 470                 475                 480 


Thr Leu Gly Ile Pro Asp Val Ile Met Gly Ile Thr Phe Leu Ala Ala 
                485                 490                 495     


Gly Thr Ser Val Pro Asp Cys Met Ala Ser Leu Ile Val Ala Arg Gln 
            500                 505                 510         


Gly Leu Gly Asp Met Ala Val Ser Asn Thr Ile Gly Ser Asn Val Phe 
        515                 520                 525             


Asp Ile Leu Val Gly Leu Gly Val Pro Trp Gly Leu Gln Thr Met Val 
    530                 535                 540                 


Val Asn Tyr Gly Ser Thr Val Lys Ile Asn Ser Arg Gly Leu Val Tyr 
545                 550                 555                 560 


Ser Val Val Leu Leu Leu Gly Ser Val Ala Leu Thr Val Leu Gly Ile 
                565                 570                 575     


His Leu Asn Lys Trp Arg Leu Asp Arg Lys Leu Gly Val Tyr Val Leu 
            580                 585                 590         


Val Leu Tyr Ala Ile Phe Leu Cys Phe Ser Ile Met Ile Glu Phe Asn 
        595                 600                 605             


Val Phe Thr Phe Val Asn Leu Pro Met Cys Arg Glu Asp Asp 
    610                 615                 620         


<210>  129
<211>  1222
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Ser Glu Ala Pro Arg Phe Phe Val Gly Pro Glu Asp Thr Glu Ile 
1               5                   10                  15      


Asn Pro Gly Asn Tyr Arg His Phe Phe His His Ala Asp Glu Asp Asp 
            20                  25                  30          


Glu Glu Glu Asp Asp Ser Pro Pro Glu Arg Gln Ile Val Val Gly Ile 
        35                  40                  45              


Cys Ser Met Ala Lys Lys Ser Lys Ser Lys Pro Met Lys Glu Ile Leu 
    50                  55                  60                  


Glu Arg Ile Ser Leu Phe Lys Tyr Ile Thr Val Val Val Phe Glu Glu 
65                  70                  75                  80  


Glu Val Ile Leu Asn Glu Pro Val Glu Asn Trp Pro Leu Cys Asp Cys 
                85                  90                  95      


Leu Ile Ser Phe His Ser Lys Gly Phe Pro Leu Asp Lys Ala Val Ala 
            100                 105                 110         


Tyr Ala Lys Leu Arg Asn Pro Phe Val Ile Asn Asp Leu Asn Met Gln 
        115                 120                 125             


Tyr Leu Ile Gln Asp Arg Arg Glu Val Tyr Ser Ile Leu Gln Ala Glu 
    130                 135                 140                 


Gly Ile Leu Leu Pro Arg Tyr Ala Ile Leu Asn Arg Asp Pro Asn Asn 
145                 150                 155                 160 


Pro Lys Glu Cys Asn Leu Ile Glu Gly Glu Asp His Val Glu Val Asn 
                165                 170                 175     


Gly Glu Val Phe Gln Lys Pro Phe Val Glu Lys Pro Val Ser Ala Glu 
            180                 185                 190         


Asp His Asn Val Tyr Ile Tyr Tyr Pro Thr Ser Ala Gly Gly Gly Ser 
        195                 200                 205             


Gln Arg Leu Phe Arg Lys Ile Gly Ser Arg Ser Ser Val Tyr Ser Pro 
    210                 215                 220                 


Glu Ser Asn Val Arg Lys Thr Gly Ser Tyr Ile Tyr Glu Glu Phe Met 
225                 230                 235                 240 


Pro Thr Asp Gly Thr Asp Val Lys Val Tyr Thr Val Gly Pro Asp Tyr 
                245                 250                 255     


Ala His Ala Glu Ala Arg Lys Ser Pro Ala Leu Asp Gly Lys Val Glu 
            260                 265                 270         


Arg Asp Ser Glu Gly Lys Glu Val Arg Tyr Pro Val Ile Leu Asn Ala 
        275                 280                 285             


Arg Glu Lys Leu Ile Ala Trp Lys Val Cys Leu Ala Phe Lys Gln Thr 
    290                 295                 300                 


Val Cys Gly Phe Asp Leu Leu Arg Ala Asn Gly Gln Ser Tyr Val Cys 
305                 310                 315                 320 


Asp Val Asn Gly Phe Ser Phe Val Lys Asn Ser Met Lys Tyr Tyr Asp 
                325                 330                 335     


Asp Cys Ala Lys Ile Leu Gly Asn Ile Val Met Arg Glu Leu Ala Pro 
            340                 345                 350         


Gln Phe His Ile Pro Trp Ser Ile Pro Leu Glu Ala Glu Asp Ile Pro 
        355                 360                 365             


Ile Val Pro Thr Thr Ser Gly Thr Met Met Glu Leu Arg Cys Val Ile 
    370                 375                 380                 


Ala Val Ile Arg His Gly Asp Arg Thr Pro Lys Gln Lys Met Lys Met 
385                 390                 395                 400 


Glu Val Arg His Gln Lys Phe Phe Asp Leu Phe Glu Lys Cys Asp Gly 
                405                 410                 415     


Tyr Lys Ser Gly Lys Leu Lys Leu Lys Lys Pro Lys Gln Leu Gln Glu 
            420                 425                 430         


Val Leu Asp Ile Ala Arg Gln Leu Leu Met Glu Leu Gly Gln Asn Asn 
        435                 440                 445             


Asp Ser Glu Ile Glu Glu Asn Lys Pro Lys Leu Glu Gln Leu Lys Thr 
    450                 455                 460                 


Val Leu Glu Met Tyr Gly His Phe Ser Gly Ile Asn Arg Lys Val Gln 
465                 470                 475                 480 


Leu Thr Tyr Leu Pro His Gly Cys Pro Lys Thr Ser Ser Glu Glu Glu 
                485                 490                 495     


Asp Ser Arg Arg Glu Glu Pro Ser Leu Leu Leu Val Leu Lys Trp Gly 
            500                 505                 510         


Gly Glu Leu Thr Pro Ala Gly Arg Val Gln Ala Glu Glu Leu Gly Arg 
        515                 520                 525             


Ala Phe Arg Cys Met Tyr Pro Gly Gly Gln Gly Asp Tyr Ala Gly Phe 
    530                 535                 540                 


Pro Gly Cys Gly Leu Leu Arg Leu His Ser Thr Tyr Arg His Asp Leu 
545                 550                 555                 560 


Lys Ile Tyr Ala Ser Asp Glu Gly Arg Val Gln Met Thr Ala Ala Ala 
                565                 570                 575     


Phe Ala Lys Gly Leu Leu Ala Leu Glu Gly Glu Leu Thr Pro Ile Leu 
            580                 585                 590         


Val Gln Met Val Lys Ser Ala Asn Met Asn Gly Leu Leu Asp Ser Asp 
        595                 600                 605             


Ser Asp Ser Leu Ser Ser Cys Gln Gln Arg Val Lys Ala Arg Leu His 
    610                 615                 620                 


Glu Ile Leu Gln Lys Asp Arg Asp Phe Thr Ala Glu Asp Tyr Glu Lys 
625                 630                 635                 640 


Leu Thr Pro Ser Gly Ser Ile Ser Leu Ile Lys Ser Met His Leu Ile 
                645                 650                 655     


Lys Asn Pro Val Lys Thr Cys Asp Lys Val Tyr Ser Leu Ile Gln Ser 
            660                 665                 670         


Leu Thr Ser Gln Ile Arg His Arg Met Glu Asp Pro Lys Ser Ser Asp 
        675                 680                 685             


Ile Gln Leu Tyr His Ser Glu Thr Leu Glu Leu Met Leu Arg Arg Trp 
    690                 695                 700                 


Ser Lys Leu Glu Lys Asp Phe Lys Thr Lys Asn Gly Arg Tyr Asp Ile 
705                 710                 715                 720 


Ser Lys Ile Pro Asp Ile Tyr Asp Cys Ile Lys Tyr Asp Val Gln His 
                725                 730                 735     


Asn Gly Ser Leu Lys Leu Glu Asn Thr Met Glu Leu Tyr Arg Leu Ser 
            740                 745                 750         


Lys Ala Leu Ala Asp Ile Val Ile Pro Gln Glu Tyr Gly Ile Thr Lys 
        755                 760                 765             


Ala Glu Lys Leu Glu Ile Ala Lys Gly Tyr Cys Thr Pro Leu Val Arg 
    770                 775                 780                 


Lys Ile Arg Ser Asp Leu Gln Arg Thr Gln Asp Asp Asp Thr Val Asn 
785                 790                 795                 800 


Lys Leu His Pro Val Tyr Ser Arg Gly Val Leu Ser Pro Glu Arg His 
                805                 810                 815     


Val Arg Thr Arg Leu Tyr Phe Thr Ser Glu Ser His Val His Ser Leu 
            820                 825                 830         


Leu Ser Ile Leu Arg Tyr Gly Ala Leu Cys Asn Glu Ser Lys Asp Glu 
        835                 840                 845             


Gln Trp Lys Arg Ala Met Asp Tyr Leu Asn Val Val Asn Glu Leu Asn 
    850                 855                 860                 


Tyr Met Thr Gln Ile Val Ile Met Leu Tyr Glu Asp Pro Asn Lys Asp 
865                 870                 875                 880 


Leu Ser Ser Glu Glu Arg Phe His Val Glu Leu His Phe Ser Pro Gly 
                885                 890                 895     


Ala Lys Gly Cys Glu Glu Asp Lys Asn Leu Pro Ser Gly Tyr Gly Tyr 
            900                 905                 910         


Arg Pro Ala Ser Arg Glu Asn Glu Gly Arg Arg Pro Phe Lys Ile Asp 
        915                 920                 925             


Asn Asp Asp Glu Pro His Thr Ser Lys Arg Asp Glu Val Asp Arg Ala 
    930                 935                 940                 


Val Ile Leu Phe Lys Pro Met Val Ser Glu Pro Ile His Ile His Arg 
945                 950                 955                 960 


Lys Ser Pro Leu Pro Arg Ser Arg Lys Thr Ala Thr Asn Asp Glu Glu 
                965                 970                 975     


Ser Pro Leu Ser Val Ser Ser Pro Glu Gly Thr Gly Thr Trp Leu His 
            980                 985                 990         


Tyr Thr Ser Gly Val Gly Thr Gly  Arg Arg Arg Arg Arg  Ser Gly Glu 
        995                 1000                 1005             


Gln Ile  Thr Ser Ser Pro Val  Ser Pro Lys Ser Leu  Ala Phe Thr 
    1010                 1015                 1020             


Ser Ser  Ile Phe Gly Ser Trp  Gln Gln Val Val Ser  Glu Asn Ala 
    1025                 1030                 1035             


Asn Tyr  Leu Arg Thr Pro Arg  Thr Leu Val Glu Gln  Lys Gln Asn 
    1040                 1045                 1050             


Pro Thr  Val Gly Ser His Cys  Ala Gly Leu Phe Ser  Thr Ser Val 
    1055                 1060                 1065             


Leu Gly  Gly Ser Ser Ser Ala  Pro Asn Leu Gln Asp  Tyr Ala Arg 
    1070                 1075                 1080             


Thr His  Arg Lys Lys Leu Thr  Ser Ser Gly Cys Ile  Asp Gly Phe 
    1085                 1090                 1095             


Glu Leu  Tyr Ser Met Val Pro  Ser Ile Cys Pro Leu  Glu Thr Leu 
    1100                 1105                 1110             


His Asn  Ala Leu Ser Leu Lys  Gln Val Asp Glu Phe  Leu Ala Ser 
    1115                 1120                 1125             


Ile Ala  Ser Pro Ser Ser Asp  Val Pro Arg Lys Thr  Ala Glu Ile 
    1130                 1135                 1140             


Ser Ser  Thr Ala Leu Arg Ser  Ser Pro Ile Met Arg  Lys Lys Val 
    1145                 1150                 1155             


Ser Leu  Asn Thr Tyr Thr Pro  Ala Lys Ile Leu Pro  Thr Pro Pro 
    1160                 1165                 1170             


Ala Thr  Leu Lys Ser Thr Lys  Ala Ser Ser Lys Pro  Ala Thr Ser 
    1175                 1180                 1185             


Gly Pro  Ser Ser Ala Val Val  Pro Asn Thr Ser Ser  Arg Lys Lys 
    1190                 1195                 1200             


Asn Ile  Thr Ser Lys Thr Glu  Thr His Glu His Lys  Lys Asn Thr 
    1205                 1210                 1215             


Gly Lys  Lys Lys 
    1220         


<210>  130
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ser His Ala Ala Glu Pro Ala Arg Asp Gly Val Glu Ala Ser Ala 
1               5                   10                  15      


Glu Gly Pro Arg Ala Val Phe Val Leu Leu Glu Glu Arg Arg Pro Ala 
            20                  25                  30          


Asp Ser Ala Gln Leu Leu Ser Leu Asn Ser Leu Leu Pro Glu Ser Gly 
        35                  40                  45              


Ile Val Ala Asp Ile Glu Leu Glu Asn Val Leu Asp Pro Asp Ser Phe 
    50                  55                  60                  


Tyr Glu Leu Lys Ser Gln Pro Leu Pro Leu Arg Ser Ser Leu Pro Ile 
65                  70                  75                  80  


Ser Leu Gln Ala Thr Pro Ala Thr Pro Ala Thr Leu Ser Ala Ser Ser 
                85                  90                  95      


Ser Ala Gly Gly Ser Arg Thr Pro Ala Met Ser Ser Ser Ser Ser Ser 
            100                 105                 110         


Arg Val Leu Leu Arg Gln Gln Leu Met Arg Ala Gln Ala Gln Glu Gln 
        115                 120                 125             


Glu Arg Arg Glu Arg Arg Glu Gln Ala Ala Ala Ala Pro Phe Pro Ser 
    130                 135                 140                 


Pro Ala Pro Ala Ser Pro Ala Ile Ser Val Val Gly Val Ser Ala Gly 
145                 150                 155                 160 


Gly His Thr Leu Ser Arg Pro Pro Pro Ala Gln Val Pro Arg Glu Val 
                165                 170                 175     


Leu Lys Val Gln Thr His Leu Glu Asn Pro Thr Arg Tyr His Leu Gln 
            180                 185                 190         


Gln Ala Arg Arg Gln Gln Val Lys Gln Tyr Leu Ser Thr Thr Leu Gly 
        195                 200                 205             


Pro Lys Leu Ala Ser Gln Ala Leu Thr Pro Pro Pro Gly Pro Ala Ser 
    210                 215                 220                 


Ala Gln Pro Leu Pro Ala Pro Glu Ala Ala His Thr Thr Gly Pro Thr 
225                 230                 235                 240 


Gly Ser Ala Pro Asn Ser Pro Met Ala Leu Leu Thr Ile Gly Ser Ser 
                245                 250                 255     


Ser Glu Lys Glu Ile Asp Asp Val Ile Asp Glu Ile Ile Ser Leu Glu 
            260                 265                 270         


Ser Ser Tyr Asn Asp Glu Met Leu Ser Tyr Leu Pro Gly Gly Thr Thr 
        275                 280                 285             


Gly Leu Gln Leu Pro Ser Thr Leu Pro Val Ser Gly Asn Leu Leu Asp 
    290                 295                 300                 


Val Tyr Ser Ser Gln Gly Val Ala Thr Pro Ala Ile Thr Val Ser Asn 
305                 310                 315                 320 


Ser Cys Pro Ala Glu Leu Pro Asn Ile Lys Arg Glu Ile Ser Glu Thr 
                325                 330                 335     


Glu Ala Lys Ala Leu Leu Lys Glu Arg Gln Lys Lys Asp Asn His Asn 
            340                 345                 350         


Leu Ile Glu Arg Arg Arg Arg Phe Asn Ile Asn Asp Arg Ile Lys Glu 
        355                 360                 365             


Leu Gly Thr Leu Ile Pro Lys Ser Ser Asp Pro Glu Met Arg Trp Asn 
    370                 375                 380                 


Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Lys Leu Gln 
385                 390                 395                 400 


Lys Glu Gln Gln Arg Ser Lys Asp Leu Glu Ser Arg Gln Arg Ser Leu 
                405                 410                 415     


Glu Gln Ala Asn Arg Ser Leu Gln Leu Arg Ile Gln Glu Leu Glu Leu 
            420                 425                 430         


Gln Ala Gln Ile His Gly Leu Pro Val Pro Pro Thr Pro Gly Leu Leu 
        435                 440                 445             


Ser Leu Ala Thr Thr Ser Ala Ser Asp Ser Leu Lys Pro Glu Gln Leu 
    450                 455                 460                 


Asp Ile Glu Glu Glu Gly Arg Pro Gly Ala Ala Thr Phe His Val Gly 
465                 470                 475                 480 


Gly Gly Pro Ala Gln Asn Ala Pro His Gln Gln Pro Pro Ala Pro Pro 
                485                 490                 495     


Ser Asp Ala Leu Leu Asp Leu His Phe Pro Ser Asp His Leu Gly Asp 
            500                 505                 510         


Leu Gly Asp Pro Phe His Leu Gly Leu Glu Asp Ile Leu Met Glu Glu 
        515                 520                 525             


Glu Glu Gly Val Val Gly Gly Leu Ser Gly Gly Ala Leu Ser Pro Leu 
    530                 535                 540                 


Arg Ala Ala Ser Asp Pro Leu Leu Ser Ser Val Ser Pro Ala Val Ser 
545                 550                 555                 560 


Lys Ala Ser Ser Arg Arg Ser Ser Phe Ser Met Glu Glu Glu Ser 
                565                 570                 575 


<210>  131
<211>  1391
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Asn Ser Pro Val Asp Pro Gly Ala Arg Gln Ala Leu Arg Lys Lys 
1               5                   10                  15      


Pro Pro Glu Arg Thr Pro Glu Asp Leu Asn Thr Ile Tyr Ser Tyr Leu 
            20                  25                  30          


His Gly Met Glu Ile Leu Ser Asn Leu Arg Glu His Gln Leu Arg Leu 
        35                  40                  45              


Met Ser Ala Arg Ala Arg Tyr Glu Arg Tyr Ser Gly Asn Gln Val Leu 
    50                  55                  60                  


Phe Cys Ser Glu Thr Ile Ala Arg Cys Trp Tyr Ile Leu Leu Ser Gly 
65                  70                  75                  80  


Ser Val Leu Val Lys Gly Ser Met Val Leu Pro Pro Cys Ser Phe Gly 
                85                  90                  95      


Lys Gln Phe Gly Gly Lys Arg Gly Cys Asp Cys Leu Val Leu Glu Pro 
            100                 105                 110         


Ser Glu Met Ile Val Val Glu Asn Ala Lys Asp Asn Glu Asp Ser Ile 
        115                 120                 125             


Leu Gln Arg Glu Ile Pro Ala Arg Gln Ser Arg Arg Arg Phe Arg Lys 
    130                 135                 140                 


Ile Asn Tyr Lys Gly Glu Arg Gln Thr Ile Thr Asp Asp Val Glu Val 
145                 150                 155                 160 


Asn Ser Tyr Leu Ser Leu Pro Ala Asp Leu Thr Lys Met His Leu Thr 
                165                 170                 175     


Glu Asn Pro His Pro Gln Val Thr His Val Ser Ser Ser Gln Ser Gly 
            180                 185                 190         


Cys Ser Ile Ala Ser Asp Ser Gly Ser Ser Ser Leu Ser Asp Ile Tyr 
        195                 200                 205             


Gln Ala Thr Glu Ser Glu Val Gly Asp Val Asp Leu Thr Arg Leu Pro 
    210                 215                 220                 


Glu Gly Pro Val Asp Ser Glu Asp Asp Glu Glu Glu Asp Glu Glu Ile 
225                 230                 235                 240 


Asp Arg Thr Asp Pro Leu Gln Gly Arg Asp Leu Val Arg Glu Cys Leu 
                245                 250                 255     


Glu Lys Glu Pro Ala Asp Lys Thr Asp Asp Asp Ile Glu Gln Leu Leu 
            260                 265                 270         


Glu Phe Met His Gln Leu Pro Ala Phe Ala Asn Met Thr Met Ser Val 
        275                 280                 285             


Arg Arg Glu Leu Cys Ser Val Met Ile Phe Glu Val Val Glu Gln Ala 
    290                 295                 300                 


Gly Ala Ile Ile Leu Glu Asp Gly Gln Glu Leu Asp Ser Trp Tyr Val 
305                 310                 315                 320 


Ile Leu Asn Gly Thr Val Glu Ile Ser His Pro Asp Gly Lys Val Glu 
                325                 330                 335     


Asn Leu Phe Met Gly Asn Ser Phe Gly Ile Thr Pro Thr Leu Asp Lys 
            340                 345                 350         


Gln Tyr Met His Gly Ile Val Arg Thr Lys Val Asp Asp Cys Gln Phe 
        355                 360                 365             


Val Cys Ile Ala Gln Gln Asp Tyr Trp Arg Ile Leu Asn His Val Glu 
    370                 375                 380                 


Lys Asn Thr His Lys Val Glu Glu Glu Gly Glu Ile Val Met Val His 
385                 390                 395                 400 


Glu His Arg Glu Leu Asp Arg Ser Gly Thr Arg Lys Gly His Ile Val 
                405                 410                 415     


Ile Lys Ala Thr Pro Glu Arg Leu Ile Met His Leu Ile Glu Glu His 
            420                 425                 430         


Ser Ile Val Asp Pro Thr Tyr Ile Glu Asp Phe Leu Leu Thr Tyr Arg 
        435                 440                 445             


Thr Phe Leu Glu Ser Pro Leu Asp Val Gly Ile Lys Leu Leu Glu Trp 
    450                 455                 460                 


Phe Lys Ile Asp Ser Leu Arg Asp Lys Val Thr Arg Ile Val Leu Leu 
465                 470                 475                 480 


Trp Val Asn Asn His Phe Asn Asp Phe Glu Gly Asp Pro Ala Met Thr 
                485                 490                 495     


Arg Phe Leu Glu Glu Phe Glu Lys Asn Leu Glu Asp Thr Lys Met Asn 
            500                 505                 510         


Gly His Leu Arg Leu Leu Asn Ile Ala Cys Ala Ala Lys Ala Lys Trp 
        515                 520                 525             


Arg Gln Val Val Leu Gln Lys Ala Ser Arg Glu Ser Pro Leu Gln Phe 
    530                 535                 540                 


Ser Leu Asn Gly Gly Ser Glu Lys Gly Phe Gly Ile Phe Val Glu Gly 
545                 550                 555                 560 


Val Glu Pro Gly Ser Lys Ala Ala Asp Ser Gly Leu Lys Arg Gly Asp 
                565                 570                 575     


Gln Ile Met Glu Val Asn Gly Gln Asn Phe Glu Asn Ile Thr Phe Met 
            580                 585                 590         


Lys Ala Val Glu Ile Leu Arg Asn Asn Thr His Leu Ala Leu Thr Val 
        595                 600                 605             


Lys Thr Asn Ile Phe Val Phe Lys Glu Leu Leu Phe Arg Thr Glu Gln 
    610                 615                 620                 


Glu Lys Ser Gly Val Pro His Ile Pro Lys Ile Ala Glu Lys Lys Ser 
625                 630                 635                 640 


Asn Arg His Ser Ile Gln His Val Pro Gly Asp Ile Glu Gln Thr Ser 
                645                 650                 655     


Gln Glu Lys Gly Ser Lys Lys Val Lys Ala Asn Thr Val Ser Gly Gly 
            660                 665                 670         


Arg Asn Lys Ile Arg Lys Ile Leu Asp Lys Thr Arg Phe Ser Ile Leu 
        675                 680                 685             


Pro Pro Lys Leu Phe Ser Asp Gly Gly Leu Ser Gln Ser Gln Asp Asp 
    690                 695                 700                 


Ser Ile Val Gly Thr Arg His Cys Arg His Ser Leu Ala Ile Met Pro 
705                 710                 715                 720 


Ile Pro Gly Thr Leu Ser Ser Ser Ser Pro Asp Leu Leu Gln Pro Thr 
                725                 730                 735     


Thr Ser Met Leu Asp Phe Ser Asn Pro Ser Asp Ile Pro Asp Gln Val 
            740                 745                 750         


Ile Arg Val Phe Lys Val Asp Gln Gln Ser Cys Tyr Ile Ile Ile Ser 
        755                 760                 765             


Lys Asp Thr Thr Ala Lys Glu Val Val Phe His Ala Val His Glu Phe 
    770                 775                 780                 


Gly Leu Thr Gly Ala Ser Asp Thr Tyr Ser Leu Cys Glu Val Ser Val 
785                 790                 795                 800 


Thr Pro Glu Gly Val Ile Lys Gln Arg Arg Leu Pro Asp Gln Phe Ser 
                805                 810                 815     


Lys Leu Ala Asp Arg Ile Gln Leu Asn Gly Arg Tyr Tyr Leu Lys Asn 
            820                 825                 830         


Asn Met Glu Thr Glu Thr Leu Cys Ser Asp Glu Asp Ala Gln Glu Leu 
        835                 840                 845             


Val Lys Glu Ser Gln Leu Ser Met Leu Gln Leu Ser Thr Ile Glu Val 
    850                 855                 860                 


Ala Thr Gln Leu Ser Met Arg Asp Phe Asp Leu Phe Arg Asn Ile Glu 
865                 870                 875                 880 


Pro Thr Glu Tyr Ile Asp Asp Leu Phe Lys Leu Asn Ser Lys Thr Gly 
                885                 890                 895     


Asn Thr His Leu Lys Arg Phe Glu Asp Ile Val Asn Gln Glu Thr Phe 
            900                 905                 910         


Trp Val Ala Ser Glu Ile Leu Thr Glu Ala Asn Gln Leu Lys Arg Met 
        915                 920                 925             


Lys Ile Ile Lys His Phe Ile Lys Ile Ala Leu His Cys Arg Glu Cys 
    930                 935                 940                 


Lys Asn Phe Asn Ser Met Phe Ala Ile Ile Ser Gly Leu Asn Leu Ala 
945                 950                 955                 960 


Ser Val Ala Arg Leu Arg Gly Thr Trp Glu Lys Leu Pro Ser Lys Tyr 
                965                 970                 975     


Glu Lys His Leu Gln Asp Leu Gln Asp Ile Phe Asp Pro Ser Arg Asn 
            980                 985                 990         


Met Ala Lys Tyr Arg Asn Ile Leu  Ser Ser Gln Ser Met  Gln Pro Pro 
        995                 1000                 1005             


Ile Ile  Pro Leu Phe Pro Val  Val Lys Lys Asp Met  Thr Phe Leu 
    1010                 1015                 1020             


His Glu  Gly Asn Asp Ser Lys  Val Asp Gly Leu Val  Asn Phe Glu 
    1025                 1030                 1035             


Lys Leu  Arg Met Ile Ser Lys  Glu Ile Arg Gln Val  Val Arg Met 
    1040                 1045                 1050             


Thr Ser  Ala Asn Met Asp Pro  Ala Met Met Phe Arg  Gln Arg Ser 
    1055                 1060                 1065             


Leu Ser  Gln Gly Ser Thr Asn  Ser Asn Met Leu Asp  Val Gln Gly 
    1070                 1075                 1080             


Gly Ala  His Lys Lys Arg Ala  Arg Arg Ser Ser Leu  Leu Asn Ala 
    1085                 1090                 1095             


Lys Lys  Leu Tyr Glu Asp Ala  Gln Met Ala Arg Lys  Val Lys Gln 
    1100                 1105                 1110             


Tyr Leu  Ser Ser Leu Asp Val  Glu Thr Asp Glu Glu  Lys Phe Gln 
    1115                 1120                 1125             


Met Met  Ser Leu Gln Trp Glu  Pro Ala Tyr Gly Thr  Leu Thr Lys 
    1130                 1135                 1140             


Asn Leu  Ser Glu Lys Arg Ser  Ala Lys Ser Ser Glu  Met Ser Pro 
    1145                 1150                 1155             


Val Pro  Met Arg Ser Ala Gly  Gln Thr Thr Lys Ala  His Leu His 
    1160                 1165                 1170             


Gln Pro  His Arg Val Ser Gln  Val Leu Gln Val Pro  Ala Val Asn 
    1175                 1180                 1185             


Leu His  Pro Ile Arg Lys Lys  Gly Gln Thr Lys Asp  Pro Ala Leu 
    1190                 1195                 1200             


Asn Thr  Ser Leu Pro Gln Lys  Val Leu Gly Thr Thr  Glu Glu Ile 
    1205                 1210                 1215             


Ser Gly  Lys Lys His Thr Glu  Asp Thr Ile Ser Val  Ala Ser Ser 
    1220                 1225                 1230             


Leu His  Ser Ser Pro Pro Ala  Ser Pro Gln Gly Ser  Pro His Lys 
    1235                 1240                 1245             


Val Gly  Ser Ile Ile Ser Asp  His Ser Ser Lys Ile  Ser Gly Gln 
    1250                 1255                 1260             


Ser Cys  Pro Gly Ile Gly Gly  Ala Tyr Leu Gln Lys  Lys Ile Leu 
    1265                 1270                 1275             


Gln Ile  Thr Arg Ser Thr Ala  Lys Arg Thr Asp Ser  Thr Glu Lys 
    1280                 1285                 1290             


Ala Thr  Glu Glu Asn Arg Asp  Arg Thr Ser Cys Glu  Asn Thr Thr 
    1295                 1300                 1305             


Arg Lys  Arg Met Thr Ser Pro  Phe Arg Arg Leu Arg  Glu Arg Met 
    1310                 1315                 1320             


Leu Ser  Arg Glu Arg Leu Val  Asn Ser Gln Lys Glu  Asp Thr Asp 
    1325                 1330                 1335             


His Asn  Gln Ala Thr Glu Ser  Cys Glu Lys Val Lys  Asp Val Gly 
    1340                 1345                 1350             


Ser Asn  Ile Lys Asp Glu Lys  Gly Ser Ala Ile Phe  Asn Ser Asn 
    1355                 1360                 1365             


Ser Gln  Gly Asn Ser Asn Thr  Leu Asn Cys Phe Tyr  Thr Arg Phe 
    1370                 1375                 1380             


Lys Ser  Lys Arg Arg Lys Thr  Leu 
    1385                 1390     


<210>  132
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Glu Asp Ser Asp Ser Ala Ala Lys Gln Leu Gly Leu Ala Glu Ala 
1               5                   10                  15      


Ala Ala Val Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Gly Gly Glu Ala Glu Glu Pro Val Leu Ser Arg Asp Glu Asp Ser 
        35                  40                  45              


Glu Glu Asp Ala Asp Ser Glu Ala Glu Arg Glu Thr Pro Arg Val Thr 
    50                  55                  60                  


Ala Val Ala Val Met Ala Ala Glu Pro Gly His Met Asp Met Gly Ala 
65                  70                  75                  80  


Glu Ala Leu Pro Gly Pro Asp Glu Ala Ala Ala Ala Ala Ala Phe Ala 
                85                  90                  95      


Glu Val Thr Thr Val Thr Val Ala Asn Val Gly Ala Ala Ala Asp Asn 
            100                 105                 110         


Val Phe Thr Thr Ser Val Ala Asn Ala Ala Ser Ile Ser Gly His Val 
        115                 120                 125             


Leu Ser Gly Arg Thr Ala Leu Gln Ile Gly Asp Ser Leu Asn Thr Glu 
    130                 135                 140                 


Lys Ala Thr Leu Ile Val Val His Thr Asp Gly Ser Ile Val Glu Thr 
145                 150                 155                 160 


Thr Gly Leu Lys Gly Pro Ala Ala Pro Leu Thr Pro Gly Pro Gln Ser 
                165                 170                 175     


Pro Pro Thr Pro Leu Ala Pro Gly Gln Glu Lys Gly Gly Thr Lys Tyr 
            180                 185                 190         


Asn Trp Asp Pro Ser Val Tyr Asp Ser Glu Leu Pro Val Arg Cys Arg 
        195                 200                 205             


Asn Ile Ser Gly Thr Leu Tyr Lys Asn Arg Leu Gly Ser Gly Gly Arg 
    210                 215                 220                 


Gly Arg Cys Ile Lys Gln Gly Glu Asn Trp Tyr Ser Pro Thr Glu Phe 
225                 230                 235                 240 


Glu Ala Met Ala Gly Arg Ala Ser Ser Lys Asp Trp Lys Arg Ser Ile 
                245                 250                 255     


Arg Tyr Ala Gly Arg Pro Leu Gln Cys Leu Ile Gln Asp Gly Ile Leu 
            260                 265                 270         


Asn Pro His Ala Ala Ser Cys Thr Cys Ala Ala Cys Cys Asp Asp Met 
        275                 280                 285             


Thr Leu Ser Gly Pro Val Arg Leu Phe Val Pro Tyr Lys Arg Arg Lys 
    290                 295                 300                 


Lys Glu Asn Glu Leu Pro Thr Thr Pro Val Lys Lys Asp Ser Pro Lys 
305                 310                 315                 320 


Asn Ile Thr Leu Leu Pro Ala Thr Ala Ala Thr Thr Phe Thr Val Thr 
                325                 330                 335     


Pro Ser Gly Gln Ile Thr Thr Ser Gly Ala Leu Thr Phe Asp Arg Ala 
            340                 345                 350         


Ser Thr Val Glu Ala Thr Ala Val Ile Ser Glu Ser Pro Ala Gln Gly 
        355                 360                 365             


Asp Val Phe Ala Gly Ala Thr Val Gln Glu Ala Ser Val Gln Pro Pro 
    370                 375                 380                 


Cys Arg Ala Ser His Pro Glu Pro His Tyr Pro Gly Tyr Gln Asp Ser 
385                 390                 395                 400 


Cys Gln Ile Ala Pro Phe Pro Glu Ala Ala Leu Pro Thr Ser His Pro 
                405                 410                 415     


Lys Ile Val Leu Thr Ser Leu Pro Ala Leu Ala Val Pro Pro Pro Thr 
            420                 425                 430         


Pro Thr Lys Ala Ala Pro Pro Ala Leu Val Asn Gly Leu Glu Leu Ser 
        435                 440                 445             


Glu Pro Arg Ser Trp Leu Tyr Leu Glu Glu Met Val Asn Ser Leu Leu 
    450                 455                 460                 


Asn Thr Ala Gln Gln Leu Lys Thr Leu Phe Glu Gln Ala Lys His Ala 
465                 470                 475                 480 


Ser Thr Tyr Arg Glu Ala Ala Thr Asn Gln Ala Lys Ile His Ala Asp 
                485                 490                 495     


Ala Glu Arg Lys Glu Gln Ser Cys Val Asn Cys Gly Arg Glu Ala Met 
            500                 505                 510         


Ser Glu Cys Thr Gly Cys His Lys Val Asn Tyr Cys Ser Thr Phe Cys 
        515                 520                 525             


Gln Arg Lys Asp Trp Lys Asp His Gln His Ile Cys Gly Gln Ser Ala 
    530                 535                 540                 


Ala Val Thr Val Gln Ala Asp Glu Val His Val Ala Glu Ser Val Met 
545                 550                 555                 560 


Glu Lys Val Thr Val 
                565 


<210>  133
<211>  1454
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Ala Pro Val Gln Leu Glu Asn His Gln Leu Val Pro Pro Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Pro Pro Ser Ala Pro Ala Pro Pro Pro 
            20                  25                  30          


Pro Gly Ala Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ser Pro Gly 
        35                  40                  45              


Tyr Arg Leu Ser Thr Leu Ile Glu Phe Leu Leu His Arg Ala Tyr Ser 
    50                  55                  60                  


Glu Leu Met Val Leu Thr Asp Leu Leu Pro Arg Lys Ser Asp Val Glu 
65                  70                  75                  80  


Arg Lys Ile Glu Ile Val Gln Phe Ala Ser Arg Thr Arg Gln Leu Phe 
                85                  90                  95      


Val Arg Leu Leu Ala Leu Val Lys Trp Ala Asn Asn Ala Gly Lys Val 
            100                 105                 110         


Glu Lys Cys Ala Met Ile Ser Ser Phe Leu Asp Gln Gln Ala Ile Leu 
        115                 120                 125             


Phe Val Asp Thr Ala Asp Arg Leu Ala Ser Leu Ala Arg Asp Ala Leu 
    130                 135                 140                 


Val His Ala Arg Leu Pro Ser Phe Ala Ile Pro Tyr Ala Ile Asp Val 
145                 150                 155                 160 


Leu Thr Thr Gly Ser Tyr Pro Arg Leu Pro Thr Cys Ile Arg Asp Lys 
                165                 170                 175     


Ile Ile Pro Pro Asp Pro Ile Thr Lys Ile Glu Lys Gln Ala Thr Leu 
            180                 185                 190         


His Gln Leu Asn Gln Ile Leu Arg His Arg Leu Val Thr Thr Asp Leu 
        195                 200                 205             


Pro Pro Gln Leu Ala Asn Leu Thr Val Ala Asn Gly Arg Val Lys Phe 
    210                 215                 220                 


Arg Val Glu Gly Glu Phe Glu Ala Thr Leu Thr Val Met Gly Asp Asp 
225                 230                 235                 240 


Pro Asp Val Pro Trp Arg Leu Leu Lys Leu Glu Ile Leu Val Glu Asp 
                245                 250                 255     


Lys Glu Thr Gly Asp Gly Arg Ala Leu Val His Ser Met Gln Ile Ser 
            260                 265                 270         


Phe Ile His Gln Leu Val Gln Ser Arg Leu Phe Ala Asp Glu Lys Pro 
        275                 280                 285             


Leu Gln Asp Met Tyr Asn Cys Leu His Ser Phe Cys Leu Ser Leu Gln 
    290                 295                 300                 


Leu Glu Val Leu His Ser Gln Thr Leu Met Leu Ile Arg Glu Arg Trp 
305                 310                 315                 320 


Gly Asp Leu Val Gln Val Glu Arg Tyr His Ala Gly Lys Cys Leu Ser 
                325                 330                 335     


Leu Ser Val Trp Asn Gln Gln Val Leu Gly Arg Lys Thr Gly Thr Ala 
            340                 345                 350         


Ser Val His Lys Val Thr Ile Lys Ile Asp Glu Asn Asp Val Ser Lys 
        355                 360                 365             


Pro Leu Gln Ile Phe His Asp Pro Pro Leu Pro Ala Ser Asp Ser Lys 
    370                 375                 380                 


Leu Val Glu Arg Ala Met Lys Ile Asp His Leu Ser Ile Glu Lys Leu 
385                 390                 395                 400 


Leu Ile Asp Ser Val His Ala Arg Ala His Gln Lys Leu Gln Glu Leu 
                405                 410                 415     


Lys Ala Ile Leu Arg Gly Phe Asn Ala Asn Glu Asn Ser Ser Ile Glu 
            420                 425                 430         


Thr Ala Leu Pro Ala Leu Val Val Pro Ile Leu Glu Pro Cys Gly Asn 
        435                 440                 445             


Ser Glu Cys Leu His Ile Phe Val Asp Leu His Ser Gly Met Phe Gln 
    450                 455                 460                 


Leu Met Leu Tyr Gly Leu Asp Gln Ala Thr Leu Asp Asp Met Glu Lys 
465                 470                 475                 480 


Ser Val Asn Asp Asp Met Lys Arg Ile Ile Pro Trp Ile Gln Gln Leu 
                485                 490                 495     


Lys Phe Trp Leu Gly Gln Gln Arg Cys Lys Gln Ser Ile Lys His Leu 
            500                 505                 510         


Pro Thr Ile Ser Ser Glu Thr Leu Gln Leu Ser Asn Tyr Ser Thr His 
        515                 520                 525             


Pro Ile Gly Asn Leu Ser Lys Asn Lys Leu Phe Ile Lys Leu Thr Arg 
    530                 535                 540                 


Leu Pro Gln Tyr Tyr Ile Val Val Glu Met Leu Glu Val Pro Asn Lys 
545                 550                 555                 560 


Pro Thr Gln Leu Ser Tyr Lys Tyr Tyr Phe Met Ser Val Asn Ala Ala 
                565                 570                 575     


Asp Arg Glu Asp Ser Pro Ala Met Ala Leu Leu Leu Gln Gln Phe Lys 
            580                 585                 590         


Glu Asn Ile Gln Asp Leu Val Phe Arg Thr Lys Thr Gly Lys Gln Thr 
        595                 600                 605             


Arg Thr Asn Ala Lys Arg Lys Leu Ser Asp Asp Pro Cys Pro Val Glu 
    610                 615                 620                 


Ser Lys Lys Thr Lys Arg Ala Gly Glu Met Cys Ala Phe Asn Lys Val 
625                 630                 635                 640 


Leu Ala His Phe Val Ala Met Cys Asp Thr Asn Met Pro Phe Val Gly 
                645                 650                 655     


Leu Arg Leu Glu Leu Ser Asn Leu Glu Ile Pro His Gln Gly Val Gln 
            660                 665                 670         


Val Glu Gly Asp Gly Phe Ser His Ala Ile Arg Leu Leu Lys Ile Pro 
        675                 680                 685             


Pro Cys Lys Gly Ile Thr Glu Glu Thr Gln Lys Ala Leu Asp Arg Ser 
    690                 695                 700                 


Leu Leu Asp Cys Thr Phe Arg Leu Gln Gly Arg Asn Asn Arg Thr Trp 
705                 710                 715                 720 


Val Ala Glu Leu Val Phe Ala Asn Cys Pro Leu Asn Gly Thr Ser Thr 
                725                 730                 735     


Arg Glu Gln Gly Pro Ser Arg His Val Tyr Leu Thr Tyr Glu Asn Leu 
            740                 745                 750         


Leu Ser Glu Pro Val Gly Gly Arg Lys Val Val Glu Met Phe Leu Asn 
        755                 760                 765             


Asp Trp Asn Ser Ile Ala Arg Leu Tyr Glu Cys Val Leu Glu Phe Ala 
    770                 775                 780                 


Arg Ser Leu Pro Asp Ile Pro Ala His Leu Asn Ile Phe Ser Glu Val 
785                 790                 795                 800 


Arg Val Tyr Asn Tyr Arg Lys Leu Ile Leu Cys Tyr Gly Thr Thr Lys 
                805                 810                 815     


Gly Ser Ser Ile Ser Ile Gln Trp Asn Ser Ile His Gln Lys Phe His 
            820                 825                 830         


Ile Ser Leu Gly Thr Val Gly Pro Asn Ser Gly Cys Ser Asn Cys His 
        835                 840                 845             


Asn Thr Ile Leu His Gln Leu Gln Glu Met Phe Asn Lys Thr Pro Asn 
    850                 855                 860                 


Val Val Gln Leu Leu Gln Val Leu Phe Asp Thr Gln Ala Pro Leu Asn 
865                 870                 875                 880 


Ala Ile Asn Lys Leu Pro Thr Val Pro Met Leu Gly Leu Thr Gln Arg 
                885                 890                 895     


Thr Asn Thr Ala Tyr Gln Cys Phe Ser Ile Leu Pro Gln Ser Ser Thr 
            900                 905                 910         


His Ile Arg Leu Ala Phe Arg Asn Met Tyr Cys Ile Asp Ile Tyr Cys 
        915                 920                 925             


Arg Ser Arg Gly Val Val Ala Ile Arg Asp Gly Ala Tyr Ser Leu Phe 
    930                 935                 940                 


Asp Asn Ser Lys Leu Val Glu Gly Phe Tyr Pro Ala Pro Gly Leu Lys 
945                 950                 955                 960 


Thr Phe Leu Asn Met Phe Val Asp Ser Asn Gln Asp Ala Arg Arg Arg 
                965                 970                 975     


Ser Val Asn Glu Asp Asp Asn Pro Pro Ser Pro Ile Gly Gly Asp Met 
            980                 985                 990         


Met Asp Ser Leu Ile Ser Gln Leu  Gln Pro Pro Pro Gln  Gln Gln Pro 
        995                 1000                 1005             


Phe Pro  Lys Gln Pro Gly Thr  Ser Gly Ala Tyr Pro  Leu Thr Ser 
    1010                 1015                 1020             


Pro Pro  Thr Ser Tyr His Ser  Thr Val Asn Gln Ser  Pro Ser Met 
    1025                 1030                 1035             


Met His  Thr Gln Ser Pro Gly  Asn Leu His Ala Ala  Ser Ser Pro 
    1040                 1045                 1050             


Ser Gly  Ala Leu Arg Ala Pro  Ser Pro Ala Ser Phe  Val Pro Thr 
    1055                 1060                 1065             


Pro Pro  Pro Ser Ser His Gly  Ile Ser Ile Gly Pro  Gly Ala Ser 
    1070                 1075                 1080             


Phe Ala  Ser Pro His Gly Thr  Leu Asp Pro Ser Ser  Pro Tyr Thr 
    1085                 1090                 1095             


Met Val  Ser Pro Ser Gly Arg  Ala Gly Asn Trp Pro  Gly Ser Pro 
    1100                 1105                 1110             


Gln Val  Ser Gly Pro Ser Pro  Ala Ala Arg Met Pro  Gly Met Ser 
    1115                 1120                 1125             


Pro Ala  Asn Pro Ser Leu His  Ser Pro Val Pro Asp  Ala Ser His 
    1130                 1135                 1140             


Ser Pro  Arg Ala Gly Thr Ser  Ser Gln Thr Met Pro  Thr Asn Met 
    1145                 1150                 1155             


Pro Pro  Pro Arg Lys Leu Pro  Gln Arg Ser Trp Ala  Ala Ser Ile 
    1160                 1165                 1170             


Pro Thr  Ile Leu Thr His Ser  Ala Leu Asn Ile Leu  Leu Leu Pro 
    1175                 1180                 1185             


Ser Pro  Thr Pro Gly Leu Val  Pro Gly Leu Ala Gly  Ser Tyr Leu 
    1190                 1195                 1200             


Cys Ser  Pro Leu Glu Arg Phe  Leu Gly Ser Val Ile  Met Arg Arg 
    1205                 1210                 1215             


His Leu  Gln Arg Ile Ile Gln  Gln Glu Thr Leu Gln  Leu Ile Asn 
    1220                 1225                 1230             


Ser Asn  Glu Pro Gly Val Ile  Met Phe Lys Thr Asp  Ala Leu Lys 
    1235                 1240                 1245             


Cys Arg  Val Ala Leu Ser Pro  Lys Thr Asn Gln Thr  Leu Gln Leu 
    1250                 1255                 1260             


Lys Val  Thr Pro Glu Asn Ala  Gly Gln Trp Lys Pro  Asp Glu Leu 
    1265                 1270                 1275             


Gln Val  Leu Glu Lys Phe Phe  Glu Thr Arg Val Ala  Gly Pro Pro 
    1280                 1285                 1290             


Phe Lys  Ala Asn Thr Leu Ile  Ala Phe Thr Lys Leu  Leu Gly Ala 
    1295                 1300                 1305             


Pro Thr  His Ile Leu Arg Asp  Cys Val His Ile Met  Lys Leu Glu 
    1310                 1315                 1320             


Leu Phe  Pro Asp Gln Ala Thr  Gln Leu Lys Trp Asn  Val Gln Phe 
    1325                 1330                 1335             


Cys Leu  Thr Ile Pro Pro Ser  Ala Pro Pro Ile Ala  Pro Pro Gly 
    1340                 1345                 1350             


Thr Pro  Ala Val Val Leu Lys  Ser Lys Met Leu Phe  Phe Leu Gln 
    1355                 1360                 1365             


Leu Thr  Gln Lys Thr Ser Val  Pro Pro Gln Glu Pro  Val Ser Ile 
    1370                 1375                 1380             


Ile Val  Pro Ile Ile Tyr Asp  Met Ala Ser Gly Thr  Thr Gln Gln 
    1385                 1390                 1395             


Ala Asp  Ile Pro Arg Gln Gln  Asn Ser Ser Val Ala  Ala Pro Met 
    1400                 1405                 1410             


Met Val  Ser Asn Ile Leu Lys  Arg Phe Ala Glu Met  Asn Pro Pro 
    1415                 1420                 1425             


Arg Gln  Gly Glu Cys Thr Ile  Phe Ala Ala Val Arg  Asp Leu Met 
    1430                 1435                 1440             


Ala Asn  Leu Thr Leu Pro Pro  Gly Gly Arg Pro 
    1445                 1450                 


<210>  134
<211>  877
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Cys Asp Leu Arg Arg Pro Ala Ala Gly Gly Met Met Asp Leu Ala 
1               5                   10                  15      


Tyr Val Cys Glu Trp Glu Lys Trp Ser Lys Ser Thr His Cys Pro Ser 
            20                  25                  30          


Val Pro Leu Ala Cys Ala Trp Ser Cys Arg Asn Leu Ile Ala Phe Thr 
        35                  40                  45              


Met Asp Leu Arg Ser Asp Asp Gln Asp Leu Thr Arg Met Ile His Ile 
    50                  55                  60                  


Leu Asp Thr Glu His Pro Trp Asp Leu His Ser Ile Pro Ser Glu His 
65                  70                  75                  80  


His Glu Ala Ile Thr Cys Leu Glu Trp Asp Gln Ser Gly Ser Arg Leu 
                85                  90                  95      


Leu Ser Ala Asp Ala Asp Gly Gln Ile Lys Cys Trp Ser Met Ala Asp 
            100                 105                 110         


His Leu Ala Asn Ser Trp Glu Ser Ser Val Gly Ser Leu Val Glu Gly 
        115                 120                 125             


Asp Pro Ile Val Ala Leu Ser Trp Leu His Asn Gly Val Lys Leu Ala 
    130                 135                 140                 


Leu His Val Glu Lys Ser Gly Ala Ser Ser Phe Gly Glu Lys Phe Ser 
145                 150                 155                 160 


Arg Val Lys Phe Ser Pro Ser Leu Thr Leu Phe Gly Gly Lys Pro Met 
                165                 170                 175     


Glu Gly Trp Ile Ala Val Thr Val Ser Gly Leu Val Thr Val Ser Leu 
            180                 185                 190         


Leu Lys Pro Ser Gly Gln Val Leu Thr Ser Thr Glu Ser Leu Cys Arg 
        195                 200                 205             


Leu Arg Gly Arg Val Ala Leu Ala Asp Ile Ala Phe Thr Gly Gly Gly 
    210                 215                 220                 


Asn Ile Val Val Ala Thr Ala Asp Gly Ser Ser Ala Ser Pro Val Gln 
225                 230                 235                 240 


Phe Tyr Lys Val Cys Val Ser Val Val Ser Glu Lys Cys Arg Ile Asp 
                245                 250                 255     


Thr Glu Ile Leu Pro Ser Leu Phe Met Arg Cys Thr Thr Asp Leu Asn 
            260                 265                 270         


Arg Lys Asp Lys Phe Pro Ala Ile Thr His Leu Lys Phe Leu Ala Arg 
        275                 280                 285             


Asp Met Ser Glu Gln Val Leu Leu Cys Ala Ser Ser Gln Thr Ser Ser 
    290                 295                 300                 


Ile Val Glu Cys Trp Ser Leu Arg Lys Glu Gly Leu Pro Val Asn Asn 
305                 310                 315                 320 


Ile Phe Gln Gln Ile Ser Pro Val Val Gly Asp Lys Gln Pro Thr Ile 
                325                 330                 335     


Leu Lys Trp Arg Ile Leu Ser Ala Thr Asn Asp Leu Asp Arg Val Ser 
            340                 345                 350         


Ala Val Ala Leu Pro Lys Leu Pro Ile Ser Leu Thr Asn Thr Asp Leu 
        355                 360                 365             


Lys Val Ala Ser Asp Thr Gln Phe Tyr Pro Gly Leu Gly Leu Ala Leu 
    370                 375                 380                 


Ala Phe His Asp Gly Ser Val His Ile Val His Arg Leu Ser Leu Gln 
385                 390                 395                 400 


Thr Met Ala Val Phe Tyr Ser Ser Ala Ala Pro Arg Pro Val Asp Glu 
                405                 410                 415     


Pro Ala Met Lys Arg Pro Arg Thr Ala Gly Pro Ala Val His Leu Lys 
            420                 425                 430         


Ala Met Gln Leu Ser Trp Thr Ser Leu Ala Leu Val Gly Ile Asp Ser 
        435                 440                 445             


His Gly Lys Leu Ser Val Leu Arg Leu Ser Pro Ser Met Gly His Pro 
    450                 455                 460                 


Leu Glu Val Gly Leu Ala Leu Arg His Leu Leu Phe Leu Leu Glu Tyr 
465                 470                 475                 480 


Cys Met Val Thr Gly Tyr Asp Trp Trp Asp Ile Leu Leu His Val Gln 
                485                 490                 495     


Pro Ser Met Val Gln Ser Leu Val Glu Lys Leu His Glu Glu Tyr Thr 
            500                 505                 510         


Arg Gln Thr Ala Ala Leu Gln Gln Val Leu Ser Thr Arg Ile Leu Ala 
        515                 520                 525             


Met Lys Ala Ser Leu Cys Lys Leu Ser Pro Cys Thr Val Thr Arg Val 
    530                 535                 540                 


Cys Asp Tyr His Thr Lys Leu Phe Leu Ile Ala Ile Ser Ser Thr Leu 
545                 550                 555                 560 


Lys Ser Leu Leu Arg Pro His Phe Leu Asn Thr Pro Asp Lys Ser Pro 
                565                 570                 575     


Gly Asp Arg Leu Thr Glu Ile Cys Thr Lys Ile Thr Asp Val Asp Ile 
            580                 585                 590         


Asp Lys Val Met Ile Asn Leu Lys Thr Glu Glu Phe Val Leu Asp Met 
        595                 600                 605             


Asn Thr Leu Gln Ala Leu Gln Gln Leu Leu Gln Trp Val Gly Asp Phe 
    610                 615                 620                 


Val Leu Tyr Leu Leu Ala Ser Leu Pro Asn Gln Gly Ser Leu Leu Arg 
625                 630                 635                 640 


Pro Gly His Ser Phe Leu Arg Asp Gly Thr Ser Leu Gly Met Leu Arg 
                645                 650                 655     


Glu Leu Met Val Val Ile Arg Ile Trp Gly Leu Leu Lys Pro Ser Cys 
            660                 665                 670         


Leu Pro Val Tyr Thr Ala Thr Ser Asp Thr Gln Asp Ser Met Ser Leu 
        675                 680                 685             


Leu Phe Arg Leu Leu Thr Lys Leu Trp Ile Cys Cys Arg Asp Glu Gly 
    690                 695                 700                 


Pro Ala Ser Glu Pro Asp Glu Ala Leu Val Asp Glu Cys Cys Leu Leu 
705                 710                 715                 720 


Pro Ser Gln Leu Leu Ile Pro Ser Leu Asp Trp Leu Pro Ala Ser Asp 
                725                 730                 735     


Gly Leu Val Ser Arg Leu Gln Pro Lys Gln Pro Leu Arg Leu Gln Phe 
            740                 745                 750         


Gly Arg Ala Pro Thr Leu Pro Gly Ser Ala Ala Thr Leu Gln Leu Asp 
        755                 760                 765             


Gly Leu Ala Arg Ala Pro Gly Gln Pro Lys Ile Asp His Leu Arg Arg 
    770                 775                 780                 


Leu His Leu Gly Ala Cys Pro Thr Glu Glu Cys Lys Ala Cys Thr Arg 
785                 790                 795                 800 


Cys Gly Cys Val Thr Met Leu Lys Ser Pro Asn Arg Thr Thr Ala Val 
                805                 810                 815     


Lys Gln Trp Glu Gln Arg Trp Ile Lys Asn Cys Leu Ala Val Glu Gly 
            820                 825                 830         


Arg Gly Pro Asp Ala Cys Val Thr Ser Arg Ala Ser Glu Glu Ala Pro 
        835                 840                 845             


Ala Phe Val Gln Leu Gly Pro Gln Ser Thr His His Ser Pro Arg Thr 
    850                 855                 860                 


Pro Arg Ser Leu Asp His Leu His Pro Glu Asp Arg Pro 
865                 870                 875         


<210>  135
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ser Ala His Asn Arg Gly Thr Glu Leu Asp Leu Ser Trp Ile Ser 
1               5                   10                  15      


Lys Ile Gln Val Asn His Pro Ala Val Leu Arg Arg Ala Glu Gln Ile 
            20                  25                  30          


Gln Ala Arg Arg Thr Val Lys Lys Glu Trp Gln Ala Ala Trp Leu Leu 
        35                  40                  45              


Lys Ala Val Thr Phe Ile Asp Leu Thr Thr Leu Ser Gly Asp Asp Thr 
    50                  55                  60                  


Ser Ser Asn Ile Gln Arg Leu Cys Tyr Lys Ala Lys Tyr Pro Ile Arg 
65                  70                  75                  80  


Glu Asp Leu Leu Lys Ala Leu Asn Met His Asp Lys Gly Ile Thr Thr 
                85                  90                  95      


Ala Ala Val Cys Val Tyr Pro Ala Arg Val Cys Asp Ala Val Lys Ala 
            100                 105                 110         


Leu Lys Ala Ala Gly Cys Asn Ile Pro Val Ala Ser Val Ala Ala Gly 
        115                 120                 125             


Phe Pro Ala Gly Gln Thr His Leu Lys Thr Arg Leu Glu Glu Ile Arg 
    130                 135                 140                 


Leu Ala Val Glu Asp Gly Ala Thr Glu Ile Asp Val Val Ile Asn Arg 
145                 150                 155                 160 


Ser Leu Val Leu Thr Gly Gln Trp Glu Ala Leu Tyr Asp Glu Ile Arg 
                165                 170                 175     


Gln Phe Arg Lys Ala Cys Gly Glu Ala His Leu Lys Thr Ile Leu Ala 
            180                 185                 190         


Thr Gly Glu Leu Gly Thr Leu Thr Asn Val Tyr Lys Ala Ser Met Ile 
        195                 200                 205             


Ala Met Met Ala Gly Ser Asp Phe Ile Lys Thr Ser Thr Gly Lys Glu 
    210                 215                 220                 


Thr Val Asn Ala Thr Phe Pro Val Ala Ile Val Met Leu Arg Ala Ile 
225                 230                 235                 240 


Arg Asp Phe Phe Trp Lys Thr Gly Asn Lys Ile Gly Phe Lys Pro Ala 
                245                 250                 255     


Gly Gly Ile Arg Ser Ala Lys Asp Ser Leu Ala Trp Leu Ser Leu Val 
            260                 265                 270         


Lys Glu Glu Leu Gly Asp Glu Trp Leu Lys Pro Glu Leu Phe Arg Ile 
        275                 280                 285             


Gly Ala Ser Thr Leu Leu Ser Asp Ile Glu Arg Gln Ile Tyr His His 
    290                 295                 300                 


Val Thr Gly Arg Tyr Ala Ala Tyr His Asp Leu Pro Met Ser 
305                 310                 315             


<210>  136
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Arg Pro Glu Pro Gly Gly Cys Cys Cys Arg Arg Thr Val Arg Ala 
1               5                   10                  15      


Asn Gly Cys Val Ala Asn Gly Glu Val Arg Asn Gly Tyr Val Arg Ser 
            20                  25                  30          


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Ile His His Val 
        35                  40                  45              


Thr Gln Asn Gly Gly Leu Tyr Lys Arg Pro Phe Asn Glu Ala Phe Glu 
    50                  55                  60                  


Glu Thr Pro Met Leu Val Ala Val Leu Thr Tyr Val Gly Tyr Gly Val 
65                  70                  75                  80  


Leu Thr Leu Phe Gly Tyr Leu Arg Asp Phe Leu Arg Tyr Trp Arg Ile 
                85                  90                  95      


Glu Lys Cys His His Ala Thr Glu Arg Glu Glu Gln Lys Asp Phe Val 
            100                 105                 110         


Ser Leu Tyr Gln Asp Phe Glu Asn Phe Tyr Thr Arg Asn Leu Tyr Met 
        115                 120                 125             


Arg Ile Arg Asp Asn Trp Asn Arg Pro Ile Cys Ser Val Pro Gly Ala 
    130                 135                 140                 


Arg Val Asp Ile Met Glu Arg Gln Ser His Asp Tyr Asn Trp Ser Phe 
145                 150                 155                 160 


Lys Tyr Thr Gly Asn Ile Ile Lys Gly Val Ile Asn Met Gly Ser Tyr 
                165                 170                 175     


Asn Tyr Leu Gly Phe Ala Arg Asn Thr Gly Ser Cys Gln Glu Ala Ala 
            180                 185                 190         


Ala Lys Val Leu Glu Glu Tyr Gly Ala Gly Val Cys Ser Thr Arg Gln 
        195                 200                 205             


Glu Ile Gly Asn Leu Asp Lys His Glu Glu Leu Glu Glu Leu Val Ala 
    210                 215                 220                 


Arg Phe Leu Gly Val Glu Ala Ala Met Ala Tyr Gly Met Gly Phe Ala 
225                 230                 235                 240 


Thr Asn Ser Met Asn Ile Pro Ala Leu Val Gly Lys Gly Cys Leu Ile 
                245                 250                 255     


Leu Ser Asp Glu Leu Asn His Ala Ser Leu Val Leu Gly Ala Arg Leu 
            260                 265                 270         


Ser Gly Ala Thr Ile Arg Ile Phe Lys His Asn Asn Met Gln Ser Leu 
        275                 280                 285             


Glu Lys Leu Leu Lys Asp Ala Ile Val Tyr Gly Gln Pro Arg Thr Arg 
    290                 295                 300                 


Arg Pro Trp Lys Lys Ile Leu Ile Leu Val Glu Gly Ile Tyr Ser Met 
305                 310                 315                 320 


Glu Gly Ser Ile Val Arg Leu Pro Glu Val Ile Ala Leu Lys Lys Lys 
                325                 330                 335     


Tyr Lys Ala Tyr Leu Tyr Leu Asp Glu Ala His Ser Ile Gly Ala Leu 
            340                 345                 350         


Gly Pro Thr Gly Arg Gly Val Val Glu Tyr Phe Gly Leu Asp Pro Glu 
        355                 360                 365             


Asp Val Asp Val Met Met Gly Thr Phe Thr Lys Ser Phe Gly Ala Ser 
    370                 375                 380                 


Gly Gly Tyr Ile Gly Gly Lys Lys Glu Leu Ile Asp Tyr Leu Arg Thr 
385                 390                 395                 400 


His Ser His Ser Ala Val Tyr Ala Thr Ser Leu Ser Pro Pro Val Val 
                405                 410                 415     


Glu Gln Ile Ile Thr Ser Met Lys Cys Ile Met Gly Gln Asp Gly Thr 
            420                 425                 430         


Ser Leu Gly Lys Glu Cys Val Gln Gln Leu Ala Glu Asn Thr Arg Tyr 
        435                 440                 445             


Phe Arg Arg Arg Leu Lys Glu Met Gly Phe Ile Ile Tyr Gly Asn Glu 
    450                 455                 460                 


Asp Ser Pro Val Val Pro Leu Met Leu Tyr Met Pro Ala Lys Ile Gly 
465                 470                 475                 480 


Ala Phe Gly Arg Glu Met Leu Lys Arg Asn Ile Gly Val Val Val Val 
                485                 490                 495     


Gly Phe Pro Ala Thr Pro Ile Ile Glu Ser Arg Ala Arg Phe Cys Leu 
            500                 505                 510         


Ser Ala Ala His Thr Lys Glu Ile Leu Asp Thr Ala Leu Lys Glu Ile 
        515                 520                 525             


Asp Glu Val Gly Asp Leu Leu Gln Leu Lys Tyr Ser Arg His Arg Leu 
    530                 535                 540                 


Val Pro Leu Leu Asp Arg Pro Phe Asp Glu Thr Thr Tyr Glu Glu Thr 
545                 550                 555                 560 


Glu Asp 
        


<210>  137
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Asn Glu Tyr Pro Lys Lys Arg Lys Arg Lys Thr Leu His Pro Ser 
1               5                   10                  15      


Arg Tyr Ser Asp Ser Ser Gly Ile Ser Arg Ile Ala Asp Gly Phe Asn 
            20                  25                  30          


Gly Ile Phe Ser Asp His Cys Tyr Ser Val Cys Ser Met Arg Gln Pro 
        35                  40                  45              


Asp Leu Lys Tyr Phe Asp Asn Lys Asp Asp Asp Ser Asp Thr Glu Thr 
    50                  55                  60                  


Ser Asn Asp Leu Pro Lys Phe Ala Asp Gly Ile Lys Ala Arg Asn Arg 
65                  70                  75                  80  


Asn Gln Asn Tyr Leu Val Pro Ser Pro Val Leu Arg Ile Leu Asp His 
                85                  90                  95      


Thr Ala Phe Ser Thr Glu Lys Ser Ala Asp Ile Val Ile Cys Asp Glu 
            100                 105                 110         


Glu Cys Asp Ser Pro Glu Ser Val Asn Gln Gln Thr Gln Glu Glu Ser 
        115                 120                 125             


Pro Ile Glu Val His Thr Ala Glu Asp Val Pro Ile Ala Val Glu Val 
    130                 135                 140                 


His Ala Ile Ser Glu Asp Tyr Asp Ile Glu Thr Glu Asn Asn Ser Ser 
145                 150                 155                 160 


Glu Ser Leu Gln Asp Gln Thr Asp Glu Glu Pro Pro Ala Lys Leu Cys 
                165                 170                 175     


Lys Ile Leu Asp Lys Ser Gln Ala Leu Asn Val Thr Ala Gln Gln Lys 
            180                 185                 190         


Trp Pro Leu Leu Arg Ala Asn Ser Ser Gly Leu Tyr Lys Cys Glu Leu 
        195                 200                 205             


Cys Glu Phe Asn Ser Lys Tyr Phe Ser Asp Leu Lys Gln His Met Ile 
    210                 215                 220                 


Leu Lys His Lys Arg Thr Asp Ser Asn Val Cys Arg Val Cys Lys Glu 
225                 230                 235                 240 


Ser Phe Ser Thr Asn Met Leu Leu Ile Glu His Ala Lys Leu His Glu 
                245                 250                 255     


Glu Asp Pro Tyr Ile Cys Lys Tyr Cys Asp Tyr Lys Thr Val Ile Phe 
            260                 265                 270         


Glu Asn Leu Ser Gln His Ile Ala Asp Thr His Phe Ser Asp His Leu 
        275                 280                 285             


Tyr Trp Cys Glu Gln Cys Asp Val Gln Phe Ser Ser Ser Ser Glu Leu 
    290                 295                 300                 


Tyr Leu His Phe Gln Glu His Ser Cys Asp Glu Gln Tyr Leu Cys Gln 
305                 310                 315                 320 


Phe Cys Glu His Glu Thr Asn Asp Pro Glu Asp Leu His Ser His Val 
                325                 330                 335     


Val Asn Glu His Ala Cys Lys Leu Ile Glu Leu Ser Asp Lys Tyr Asn 
            340                 345                 350         


Asn Gly Glu His Gly Gln Tyr Ser Leu Leu Ser Lys Ile Thr Phe Asp 
        355                 360                 365             


Lys Cys Lys Asn Phe Phe Val Cys Gln Val Cys Gly Phe Arg Ser Arg 
    370                 375                 380                 


Leu His Thr Asn Val Asn Arg His Val Ala Ile Glu His Thr Lys Ile 
385                 390                 395                 400 


Phe Pro His Val Cys Asp Asp Cys Gly Lys Gly Phe Ser Ser Met Leu 
                405                 410                 415     


Glu Tyr Cys Lys His Leu Asn Ser His Leu Ser Glu Gly Ile Tyr Leu 
            420                 425                 430         


Cys Gln Tyr Cys Glu Tyr Ser Thr Gly Gln Ile Glu Asp Leu Lys Ile 
        435                 440                 445             


His Leu Asp Phe Lys His Ser Ala Asp Leu Pro His Lys Cys Ser Asp 
    450                 455                 460                 


Cys Leu Met Arg Phe Gly Asn Glu Arg Glu Leu Ile Ser His Leu Pro 
465                 470                 475                 480 


Val His Glu Thr Thr 
                485 


<210>  138
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Asp Pro Glu Cys Ala Gln Leu Leu Pro Ala Leu Cys Ala Val Leu 
1               5                   10                  15      


Val Asp Pro Arg Gln Pro Val Ala Asp Asp Thr Cys Leu Glu Lys Leu 
            20                  25                  30          


Leu Asp Trp Phe Lys Thr Val Thr Glu Gly Glu Ser Ser Val Val Leu 
        35                  40                  45              


Leu Gln Glu His Pro Cys Leu Val Glu Leu Leu Ser His Val Leu Lys 
    50                  55                  60                  


Val Gln Asp Leu Ser Ser Gly Val Leu Ser Phe Ser Leu Arg Leu Ala 
65                  70                  75                  80  


Gly Thr Phe Ala Ala Gln Glu Asn Cys Phe Gln Tyr Leu Gln Gln Gly 
                85                  90                  95      


Glu Leu Leu Pro Gly Leu Phe Gly Glu Pro Gly Pro Leu Gly Arg Ala 
            100                 105                 110         


Thr Trp Ala Val Pro Thr Val Arg Ser Gly Trp Ile Gln Gly Leu Arg 
        115                 120                 125             


Ser Leu Ala Gln His Pro Ser Ala Leu Arg Phe Leu Ala Asp His Gly 
    130                 135                 140                 


Ala Val Asp Thr Ile Phe Ser Leu Gln Gly Asp Ser Ser Leu Phe Val 
145                 150                 155                 160 


Ala Ser Ala Ala Ser Gln Leu Leu Val His Val Leu Ala Leu Ser Met 
                165                 170                 175     


Arg Gly Gly Ala Glu Gly Gln Pro Cys Leu Pro Gly Gly Asp Trp Pro 
            180                 185                 190         


Ala Cys Ala Gln Lys Ile Met Asp His Val Glu Glu Ser Leu Cys Ser 
        195                 200                 205             


Ala Ala Thr Pro Lys Val Thr Gln Ala Leu Asn Val Leu Thr Thr Thr 
    210                 215                 220                 


Phe Gly Arg Cys Gln Ser Pro Trp Thr Glu Ala Leu Trp Val Arg Leu 
225                 230                 235                 240 


Ser Pro Arg Val Ala Cys Leu Leu Glu Arg Asp Pro Ile Pro Ala Ala 
                245                 250                 255     


His Ser Phe Val Asp Leu Leu Leu Cys Val Ala Arg Ser Pro Val Phe 
            260                 265                 270         


Ser Ser Ser Asp Gly Ser Leu Trp Glu Thr Val Ala Arg Ala Leu Ser 
        275                 280                 285             


Cys Leu Gly Pro Thr His Met Gly Pro Leu Ala Leu Gly Ile Leu Lys 
    290                 295                 300                 


Leu Glu His Cys Pro Gln Ala Leu Arg Thr Gln Ala Phe Gln Val Leu 
305                 310                 315                 320 


Leu Gln Pro Leu Ala Cys Val Leu Lys Ala Thr Val Gln Ala Pro Gly 
                325                 330                 335     


Pro Pro Gly Leu Leu Asp Gly Thr Ala Asp Asp Ala Thr Thr Val Asp 
            340                 345                 350         


Thr Leu Leu Ala Ser Lys Ser Ser Cys Ala Gly Leu Leu Cys Arg Thr 
        355                 360                 365             


Leu Ala His Leu Glu Glu Leu Gln Pro Leu Pro Gln Arg Pro Ser Pro 
    370                 375                 380                 


Trp Pro Gln Ala Ser Leu Leu Gly Ala Thr Val Thr Val Leu Arg Leu 
385                 390                 395                 400 


Cys Asp Gly Ser Ala Ala Pro Ala Ser Ser Val Gly Gly His Leu Cys 
                405                 410                 415     


Gly Thr Leu Ala Gly Cys Val Arg Val Gln Arg Ala Ala Leu Asp Phe 
            420                 425                 430         


Leu Gly Thr Leu Ser Gln Gly Thr Gly Pro Gln Glu Leu Val Thr Gln 
        435                 440                 445             


Ala Leu Ala Val Leu Leu Glu Cys Leu Glu Ser Pro Gly Ser Ser Pro 
    450                 455                 460                 


Thr Val Leu Lys Lys Ala Phe Gln Ala Thr Leu Arg Trp Leu Leu Ser 
465                 470                 475                 480 


Ser Pro Lys Thr Pro Gly Cys Ser Asp Leu Gly Pro Leu Ile Pro Gln 
                485                 490                 495     


Phe Leu Arg Glu Leu Phe Pro Val Leu Gln Lys Arg Leu Cys His Pro 
            500                 505                 510         


Cys Trp Glu Val Arg Asp Ser Ala Leu Glu Phe Leu Thr Gln Leu Ser 
        515                 520                 525             


Arg His Trp Gly Gly Gln Ala Asp Phe Arg Cys Ala Leu Leu Ala Ser 
    530                 535                 540                 


Glu Val Pro Gln Leu Ala Leu Gln Leu Leu Gln Asp Pro Glu Ser Tyr 
545                 550                 555                 560 


Val Arg Ala Ser Ala Val Thr Ala Met Gly Gln Leu Ser Ser Gln Gly 
                565                 570                 575     


Leu His Ala Pro Thr Ser Pro Glu His Ala Glu Ala Arg Gln Ser Leu 
            580                 585                 590         


Phe Leu Glu Leu Leu His Ile Leu Ser Val Asp Ser Glu Gly Phe Pro 
        595                 600                 605             


Arg Arg Ala Val Met Gln Val Phe Thr Glu Trp Leu Arg Asp Gly His 
    610                 615                 620                 


Ala Asp Ala Ala Gln Asp Thr Glu Gln Phe Val Ala Thr Val Leu Gln 
625                 630                 635                 640 


Ala Ala Ser Arg Asp Leu Asp Trp Glu Val Arg Ala Gln Gly Leu Glu 
                645                 650                 655     


Leu Ala Leu Val Phe Leu Gly Gln Thr Leu Gly Pro Pro Arg Thr His 
            660                 665                 670         


Cys Pro Tyr Ala Val Ala Leu Pro Glu Val Ala Pro Ala Gln Pro Leu 
        675                 680                 685             


Thr Glu Ala Leu Arg Ala Leu Cys His Val Gly Leu Phe Asp Phe Ala 
    690                 695                 700                 


Phe Cys Ala Leu Phe Asp Cys Asp Arg Pro Val Ala Gln Lys Ser Cys 
705                 710                 715                 720 


Asp Leu Leu Leu Phe Leu Arg Asp Lys Ile Ala Ser Tyr Ser Ser Leu 
                725                 730                 735     


Arg Glu Ala Arg Gly Ser Pro Asn Thr Ala Ser Ala Glu Ala Thr Leu 
            740                 745                 750         


Pro Arg Trp Arg Ala Gly Glu Gln Ala Gln Pro Pro Gly Asp Gln Glu 
        755                 760                 765             


Pro Glu Ala Val Leu Ala Met Leu Arg Ser Leu Asp Leu Glu Gly Leu 
    770                 775                 780                 


Arg Ser Thr Leu Ala Glu Ser Ser Asp His Val Glu Lys Ser Pro Gln 
785                 790                 795                 800 


Ser Leu Leu Gln Asp Met Leu Ala Thr Gly Gly Phe Leu Gln Gly Asp 
                805                 810                 815     


Glu Ala Asp Cys Tyr 
            820     


<210>  139
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Ala Ser Ser Thr Ser Leu Pro Ala Pro Gly Ser Arg Pro Lys Lys 
1               5                   10                  15      


Pro Leu Gly Lys Met Ala Asp Trp Phe Arg Gln Thr Leu Leu Lys Lys 
            20                  25                  30          


Pro Lys Lys Arg Pro Asn Ser Pro Glu Ser Thr Ser Ser Asp Ala Ser 
        35                  40                  45              


Gln Pro Thr Ser Gln Asp Ser Pro Leu Pro Pro Ser Leu Ser Ser Val 
    50                  55                  60                  


Thr Ser Pro Ser Leu Pro Pro Thr His Ala Ser Asp Ser Gly Ser Ser 
65                  70                  75                  80  


Arg Trp Ser Lys Asp Tyr Asp Val Cys Val Cys His Ser Glu Glu Asp 
                85                  90                  95      


Leu Val Ala Ala Gln Asp Leu Val Ser Tyr Leu Glu Gly Ser Thr Ala 
            100                 105                 110         


Ser Leu Arg Cys Phe Leu Gln Leu Arg Asp Ala Thr Pro Gly Gly Ala 
        115                 120                 125             


Ile Val Ser Glu Leu Cys Gln Ala Leu Ser Ser Ser His Cys Arg Val 
    130                 135                 140                 


Leu Leu Ile Thr Pro Gly Phe Leu Gln Asp Pro Trp Cys Lys Tyr Gln 
145                 150                 155                 160 


Met Leu Gln Ala Leu Thr Glu Ala Pro Gly Ala Glu Gly Cys Thr Ile 
                165                 170                 175     


Pro Leu Leu Ser Gly Leu Ser Arg Ala Ala Tyr Pro Pro Glu Leu Arg 
            180                 185                 190         


Phe Met Tyr Tyr Val Asp Gly Arg Gly Pro Asp Gly Gly Phe Arg Gln 
        195                 200                 205             


Val Lys Glu Ala Val Met Arg Tyr Leu Gln Thr Leu Ser 
    210                 215                 220     


