
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Pangu Biopharma Limited
      Greene, Leslie Ann
      Chiang, Kyle P.
      Hong, Fei
      Vasserot, Alain P.
      Lo, Wing-Sze
      Watkins, Jeffry D.
      Mendlein, John D.
      Quinn, Cheryl L.

<120> INNOVATIVE DISCOVERY OF THERAPEUTIC,
  DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS
  OF HISTIDYL-tRNA SYNTHETASES
  

<130> 120161.450PC

<140> PCT                 
<141> 2011-07-12  

<150> US 61/363,581       
<151> 2010-07-12  

<150> US 61/363,585       
<151> 2010-07-12  

<150> US 61/363,587       
<151> 2010-07-12  

<160> 113

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc 60
tcggtctcga ttctacg                                                77

<210> 2
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 2
taatgactcg ag                                                     12

<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 3
aggagataaa acatatg                                                17

<210> 4
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 4
aggaggtaaa acat                                                   14

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 5
aggagataaa acat                                                   14

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 6
gaaggagata tacat                                                  15

<210> 7
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat 60
taatgactcg ag                                                     72

<210> 8
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat 60
tctacgggat cc                                                     72

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 9
ctcgagtaat ga                                                     12

<210> 10
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 10
catatgggat cc                                                     12

<210> 11
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac 60
caccactaat ga                                                     72

<210> 12
<211> 141
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp
    50                  55                  60                  
Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile
65                  70                  75                  80  
Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val
                85                  90                  95      
Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys
            100                 105                 110         
Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg
        115                 120                 125             
Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met
    130                 135                 140     


<210> 13
<211> 423
<212> DNA
<213> Homo sapiens

<400> 13
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc 240
atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag 300
gaaacactga tgggaaagta tggggaagac tccaagctta tctatgacct gaaggaccag 360
ggcggggagc tcctgtccct tcgctatgac ctcactgttc cttttgctcg gtatttggca 420
atg                                                               423

<210> 14
<211> 408
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp
    50                  55                  60                  
Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile
65                  70                  75                  80  
Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val
                85                  90                  95      
Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys
            100                 105                 110         
Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg
        115                 120                 125             
Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu
    130                 135                 140                 
Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn
145                 150                 155                 160 
Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe
                165                 170                 175     
Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu
            180                 185                 190         
Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu
        195                 200                 205             
Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys
    210                 215                 220                 
Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys
225                 230                 235                 240 
Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu
                245                 250                 255     
Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln
            260                 265                 270         
Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys
        275                 280                 285             
Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu
    290                 295                 300                 
Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe
305                 310                 315                 320 
Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr
                325                 330                 335     
Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu
            340                 345                 350         
Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly
        355                 360                 365             
Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile
    370                 375                 380                 
Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu
385                 390                 395                 400 
Glu Glu Lys Ile Arg Thr Thr Glu
                405             


<210> 15
<211> 1224
<212> DNA
<213> Homo sapiens

<400> 15
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc 240
atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag 300
gaaacactga tgggaaagta tggggaagac tccaagctta tctatgacct gaaggaccag 360
ggcggggagc tcctgtccct tcgctatgac ctcactgttc cttttgctcg gtatttggca 420
atgaataaac tgaccaacat taaacgctac cacatagcaa aggtatatcg gcgggataac 480
ccagccatga cccgtggccg ataccgggaa ttctaccagt gtgattttga cattgctggg 540
aactttgatc ccatgatccc tgatgcagag tgcctgaaga tcatgtgcga gatcctgagt 600
tcacttcaga taggcgactt cctggtcaag gtaaacgatc gacgcattct agatgggatg 660
tttgctatct gtggtgtttc tgacagcaag ttccgtacca tctgctcctc agtagacaag 720
ctggacaagg tgtcctggga agaggtgaag aatgagatgg tgggagagaa gggccttgca 780
cctgaggtgg ctgaccgcat tggggactat gtccagcaac atggtggggt atccctggtg 840
gaacagctgc tccaggatcc taaactatcc caaaacaagc aggccttgga gggcctggga 900
gacctgaagt tgctctttga gtacctgacc ctatttggca ttgatgacaa aatctccttt 960
gacctgagcc ttgctcgagg gctggattac tacactgggg tgatctatga ggcagtgctg 1020
ctacagaccc cagcccaggc aggggaagag cccctgggtg tgggcagtgt ggctgctgga 1080
ggacgctatg atgggctagt gggcatgttc gaccccaaag ggcgcaaggt gccatgtgtg 1140
gggctcagca ttggggtgga gcggattttc tccatcgtgg aacagagact agaggctttg 1200
gaggagaaga tacggaccac ggag                                        1224

<210> 16
<211> 12
<212> PRT
<213> Mus musculus

<400> 16
Ala Ser Ala Glu Gln Ile Glu Glu Glu Val Thr Lys
 1               5                  10          


<210> 17
<211> 49
<212> PRT
<213> Mus musculus

<400> 17
Leu Leu Lys Leu Lys Ala Gln Leu Gly Gln Asp Glu Gly Lys Gln Lys
 1               5                  10                  15      
Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln
            20                  25                  30          
Met Ala Val Arg Glu Lys Val Phe Asp Val Ile Ile Arg Cys Phe Lys
        35                  40                  45              
Arg
    


<210> 18
<211> 14
<212> PRT
<213> Mus musculus

<400> 18
His Gly Ala Glu Val Ile Asp Thr Pro Val Phe Glu Leu Lys
 1               5                  10                  


<210> 19
<211> 18
<212> PRT
<213> Mus musculus

<400> 19
Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp
 1               5                  10                  15      
Leu Lys
        


<210> 20
<211> 10
<212> PRT
<213> Mus musculus

<400> 20
Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg
 1               5                  10  


<210> 21
<211> 103
<212> PRT
<213> Mus musculus

<400> 21
Ala Ser Ala Glu Gln Ile Glu Glu Glu Val Thr Lys Leu Leu Lys Leu
 1               5                  10                  15      
Lys Ala Gln Leu Gly Gln Asp Glu Gly Lys Gln Lys Phe Val Leu Lys
            20                  25                  30          
Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg
        35                  40                  45              
Glu Lys Val Phe Asp Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala
    50                  55                  60                  
Glu Val Ile Asp Thr Pro Val Phe Glu Leu Lys Glu Thr Leu Thr Gly
65                  70                  75                  80  
Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly
                85                  90                  95      
Gly Glu Leu Leu Ser Leu Arg
            100             


<210> 22
<211> 14
<212> PRT
<213> Mus musculus

<400> 22
His Gly Ala Glu Val Ile Asp Thr Pro Val Phe Glu Leu Lys
 1               5                  10                  


<210> 23
<211> 166
<212> PRT
<213> Mus musculus

<400> 23
Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp
 1               5                  10                  15      
Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr
            20                  25                  30          
Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn Ile Lys
        35                  40                  45              
Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr
    50                  55                  60                  
Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly
65                  70                  75                  80  
Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys
                85                  90                  95      
Glu Ile Leu Ser Ser Leu Gln Ile Gly Asn Phe Leu Val Lys Val Asn
            100                 105                 110         
Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Val Cys Gly Val Pro Asp
        115                 120                 125             
Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val
    130                 135                 140                 
Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala
145                 150                 155                 160 
Pro Glu Val Ala Asp Arg
                165     


<210> 24
<211> 22
<212> PRT
<213> Mus musculus

<400> 24
Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln
 1               5                  10                  15      
Leu Leu Gln Asp Pro Lys
            20          


<210> 25
<211> 202
<212> PRT
<213> Mus musculus

<400> 25
His Gly Ala Glu Val Ile Asp Thr Pro Val Phe Glu Leu Lys Glu Thr
 1               5                  10                  15      
Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys
            20                  25                  30          
Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro
        35                  40                  45              
Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr
    50                  55                  60                  
His Ile Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly
65                  70                  75                  80  
Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Gln Phe
                85                  90                  95      
Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile
            100                 105                 110         
Leu Ser Ser Leu Gln Ile Gly Asn Phe Leu Val Lys Val Asn Asp Arg
        115                 120                 125             
Arg Ile Leu Asp Gly Met Phe Ala Val Cys Gly Val Pro Asp Ser Lys
    130                 135                 140                 
Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp
145                 150                 155                 160 
Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu
                165                 170                 175     
Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser
            180                 185                 190         
Leu Val Glu Gln Leu Leu Gln Asp Pro Lys
        195                 200         


<210> 26
<211> 60
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys
    50                  55                  60  


<210> 27
<211> 180
<212> DNA
<213> Homo sapiens

<400> 27
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180


<210> 28
<211> 270
<212> PRT
<213> Homo sapiens

<400> 28
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp
    50                  55                  60                  
Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile
65                  70                  75                  80  
Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val
                85                  90                  95      
Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys
            100                 105                 110         
Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg
        115                 120                 125             
Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu
    130                 135                 140                 
Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn
145                 150                 155                 160 
Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe
                165                 170                 175     
Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu
            180                 185                 190         
Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu
        195                 200                 205             
Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys
    210                 215                 220                 
Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys
225                 230                 235                 240 
Leu Asp Lys Val Gly Tyr Pro Trp Trp Asn Ser Cys Ser Arg Ile Leu
                245                 250                 255     
Asn Tyr Pro Lys Thr Ser Arg Pro Trp Arg Ala Trp Glu Thr
            260                 265                 270 


<210> 29
<211> 813
<212> DNA
<213> Homo sapiens

<400> 29
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc 240
atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag 300
gaaacactga tgggaaagta tggggaagac tccaagctta tctatgacct gaaggaccag 360
ggcggggagc tcctgtccct tcgctatgac ctcactgttc cttttgctcg gtatttggca 420
atgaataaac tgaccaacat taaacgctac cacatagcaa aggtatatcg gcgggataac 480
ccagccatga cccgtggccg ataccgggaa ttctaccagt gtgattttga cattgctggg 540
aactttgatc ccatgatccc tgatgcagag tgcctgaaga tcatgtgcga gatcctgagt 600
tcacttcaga taggcgactt cctggtcaag gtaaacgatc gacgcattct agatgggatg 660
tttgctatct gtggtgtttc tgacagcaag ttccgtacca tctgctcctc agtagacaag 720
ctggacaagg tggggtatcc ctggtggaac agctgctcca ggatcctaaa ctatcccaaa 780
acaagcaggc cttggagggc ctgggagacc tga                              813

<210> 30
<211> 50
<212> DNA
<213> Homo sapiens

<400> 30
gaaatttgtg ctcaaaaccc ccaagtagag acgaggtttc accatgttgg            50

<210> 31
<211> 8
<212> PRT
<213> Homo sapiens

<400> 31
Lys Phe Val Leu Lys Thr Pro Lys
 1               5              


<210> 32
<211> 50
<212> DNA
<213> Homo sapiens

<400> 32
ctcctcagta gacaagctgg acaaggtggg gtatccctgg tggaacagct            50

<210> 33
<211> 16
<212> PRT
<213> Homo sapiens

<400> 33
Ser Ser Val Asp Lys Leu Asp Lys Val Gly Tyr Pro Trp Trp Asn Ser
 1               5                  10                  15      


<210> 34
<211> 113
<212> PRT
<213> Homo sapiens

<400> 34
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp
    50                  55                  60                  
Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile
65                  70                  75                  80  
Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val
                85                  90                  95      
Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys
            100                 105                 110         
Leu
    


<210> 35
<211> 339
<212> DNA
<213> Homo sapiens

<400> 35
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc 240
atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag 300
gaaacactga tgggaaagta tggggaagac tccaagctt                        339

<210> 36
<211> 165
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 36
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu
            20                  25                  30          
Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala
        35                  40                  45              
Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys
    50                  55                  60                  
Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr
65                  70                  75                  80  
Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu
                85                  90                  95      
Lys Val Phe Asp Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu
            100                 105                 110         
Val Ile Asp Thr Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys
        115                 120                 125             
Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly
    130                 135                 140                 
Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr
145                 150                 155                 160 
Leu Ala Met Leu Glu
                165 


<210> 37
<211> 165
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 37
Met Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln
 1               5                  10                  15      
Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu
            20                  25                  30          
Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly
        35                  40                  45              
Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr
    50                  55                  60                  
Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp
65                  70                  75                  80  
Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr
                85                  90                  95      
Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp
            100                 105                 110         
Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser
        115                 120                 125             
Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Leu
    130                 135                 140                 
Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His
145                 150                 155                 160 
His His His His His
                165 


<210> 38
<211> 432
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 38
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu
            20                  25                  30          
Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala
        35                  40                  45              
Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys
    50                  55                  60                  
Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr
65                  70                  75                  80  
Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu
                85                  90                  95      
Lys Val Phe Asp Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu
            100                 105                 110         
Val Ile Asp Thr Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys
        115                 120                 125             
Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly
    130                 135                 140                 
Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr
145                 150                 155                 160 
Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr His Ile Ala Lys
                165                 170                 175     
Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu
            180                 185                 190         
Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile
        195                 200                 205             
Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu
    210                 215                 220                 
Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp
225                 230                 235                 240 
Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile
                245                 250                 255     
Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys
            260                 265                 270         
Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg
        275                 280                 285             
Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln
    290                 295                 300                 
Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly
305                 310                 315                 320 
Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile
                325                 330                 335     
Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr
            340                 345                 350         
Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln
        355                 360                 365             
Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg
    370                 375                 380                 
Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro
385                 390                 395                 400 
Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu
                405                 410                 415     
Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Leu Glu
            420                 425                 430         


<210> 39
<211> 432
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 39
Met Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln
 1               5                  10                  15      
Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu
            20                  25                  30          
Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly
        35                  40                  45              
Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr
    50                  55                  60                  
Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp
65                  70                  75                  80  
Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr
                85                  90                  95      
Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp
            100                 105                 110         
Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser
        115                 120                 125             
Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn
    130                 135                 140                 
Lys Leu Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg
145                 150                 155                 160 
Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys
                165                 170                 175     
Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu
            180                 185                 190         
Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp
        195                 200                 205             
Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala
    210                 215                 220                 
Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val
225                 230                 235                 240 
Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val
                245                 250                 255     
Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr
            260                 265                 270         
Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp
        275                 280                 285             
Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu
    290                 295                 300                 
Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile
305                 310                 315                 320 
Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val
                325                 330                 335     
Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu
            340                 345                 350         
Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu
        355                 360                 365             
Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu
    370                 375                 380                 
Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu
385                 390                 395                 400 
Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Leu Glu Gly Lys Pro Ile
                405                 410                 415     
Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
            420                 425                 430         


<210> 40
<211> 137
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 40
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu
            20                  25                  30          
Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala
        35                  40                  45              
Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys
    50                  55                  60                  
Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr
65                  70                  75                  80  
Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu
                85                  90                  95      
Lys Val Phe Asp Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu
            100                 105                 110         
Val Ile Asp Thr Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys
        115                 120                 125             
Tyr Gly Glu Asp Ser Lys Leu Leu Glu
    130                 135         


<210> 41
<211> 137
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 41
Met Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln
 1               5                  10                  15      
Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu
            20                  25                  30          
Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly
        35                  40                  45              
Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr
    50                  55                  60                  
Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp
65                  70                  75                  80  
Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr
                85                  90                  95      
Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp
            100                 105                 110         
Ser Lys Leu Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu
        115                 120                 125             
Asp Ser Thr His His His His His His
    130                 135         


<210> 42
<211> 294
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 42
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu
            20                  25                  30          
Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala
        35                  40                  45              
Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys
    50                  55                  60                  
Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr
65                  70                  75                  80  
Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu
                85                  90                  95      
Lys Val Phe Asp Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu
            100                 105                 110         
Val Ile Asp Thr Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys
        115                 120                 125             
Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly
    130                 135                 140                 
Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr
145                 150                 155                 160 
Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr His Ile Ala Lys
                165                 170                 175     
Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu
            180                 185                 190         
Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile
        195                 200                 205             
Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu
    210                 215                 220                 
Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp
225                 230                 235                 240 
Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile
                245                 250                 255     
Cys Ser Ser Val Asp Lys Leu Asp Lys Val Gly Tyr Pro Trp Trp Asn
            260                 265                 270         
Ser Cys Ser Arg Ile Leu Asn Tyr Pro Lys Thr Ser Arg Pro Trp Arg
        275                 280                 285             
Ala Trp Glu Thr Leu Glu
    290                 


<210> 43
<211> 294
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 43
Met Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln
 1               5                  10                  15      
Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu
            20                  25                  30          
Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly
        35                  40                  45              
Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr
    50                  55                  60                  
Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp
65                  70                  75                  80  
Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr
                85                  90                  95      
Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp
            100                 105                 110         
Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser
        115                 120                 125             
Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn
    130                 135                 140                 
Lys Leu Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg
145                 150                 155                 160 
Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys
                165                 170                 175     
Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu
            180                 185                 190         
Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp
        195                 200                 205             
Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala
    210                 215                 220                 
Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val
225                 230                 235                 240 
Asp Lys Leu Asp Lys Val Gly Tyr Pro Trp Trp Asn Ser Cys Ser Arg
                245                 250                 255     
Ile Leu Asn Tyr Pro Lys Thr Ser Arg Pro Trp Arg Ala Trp Glu Thr
            260                 265                 270         
Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
        275                 280                 285             
His His His His His His
    290                 


<210> 44
<211> 432
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 44
ggatccgcag aacgtgccgc cctggaagag ctggtaaaac tgcaaggcga gcgtgttcgt 60
ggtctgaaac agcagaaagc aagcgctgaa ctgatcgaag aagaagtggc gaaactgctg 120
aaactgaaag cacagctggg tcctgatgaa tcaaaacaaa aattcgtcct gaaaactccg 180
aaaggaaccc gtgactattc tcctcgtcaa atggccgtcc gtgaaaaagt gttcgacgtg 240
atcattcgct gctttaaacg ccatggtgcc gaagtgattg ataccccggt gtttgagctg 300
aaagagacac tgatgggcaa atatggtgag gacagcaaac tgatttatga cctgaaagat 360
cagggtggtg aactgctgag tctgcgctat gatctgacag ttccgtttgc ccgttatctg 420
gcaatgctcg ag                                                     432

<210> 45
<211> 1233
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 45
ggatccgcag aacgtgccgc cctggaagag ctggtaaaac tgcaaggcga gcgtgttcgt 60
ggtctgaaac agcagaaagc aagcgctgaa ctgatcgaag aagaagtggc gaaactgctg 120
aaactgaaag cacagctggg tcctgatgaa tcaaaacaaa aattcgtcct gaaaactccg 180
aaaggaaccc gtgactattc tcctcgtcaa atggccgtcc gtgaaaaagt gttcgacgtg 240
atcattcgct gctttaaacg ccatggtgcc gaagtgattg ataccccggt gtttgagctg 300
aaagagacac tgatgggcaa atatggtgag gacagcaaac tgatttatga cctgaaagat 360
cagggtggtg aactgctgag tctgcgctat gatctgacag ttccgtttgc ccgttatctg 420
gcaatgaata aactgaccaa cattaaacgc tatcacattg ctaaagtcta tcgccgtgac 480
aatcctgcta tgacccgtgg tcgttatcgt gagttctatc agtgtgactt cgatattgcc 540
ggcaactttg atccgatgat cccggatgct gaatgcctga aaatcatgtg tgagatcctg 600
agcagtctgc agattggcga tttcctggtg aaagtcaacg atcgccgtat tctggatggc 660
atgttcgcca tctgtggtgt tagcgactcc aaattccgta ccatctgtag tagtgtggac 720
aaactggata aagtgagctg ggaggaggtg aaaaacgaaa tggtgggcga gaaaggtctg 780
gctcctgaag tggctgaccg tattggtgat tatgtccagc agcacggtgg agtatcactg 840
gttgagcaac tgctgcaaga ccctaaactg agtcagaata aacaggccct ggagggactg 900
ggagatctga aactgctgtt cgagtatctg accctgttcg gtatcgatga caaaatctcc 960
tttgacctgt cactggctcg tggactggac tattataccg gcgtgatcta tgaagctgta 1020
ctgctgcaaa ctccagcaca agcaggtgaa gagcctctgg gtgtgggtag tgtagccgct 1080
gggggacgtt atgatggact ggtggggatg ttcgacccta aaggccgtaa agttccgtgt 1140
gtgggtctga gtatcggtgt tgagcgtatc ttttccatcg tcgagcaacg tctggaagca 1200
ctggaggaaa aaatccgtac gaccgaactc gag                              1233

<210> 46
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 46
ggatccgcag aacgtgccgc cctggaagag ctggtaaaac tgcaaggcga gcgtgttcgt 60
ggtctgaaac agcagaaagc aagcgctgaa ctgatcgaag aagaagtggc gaaactgctg 120
aaactgaaag cacagctggg tcctgatgaa tcaaaacaaa aattcgtcct gaaaactccg 180
aaaggaaccc gtgactattc tcctcgtcaa atggccgtcc gtgaaaaagt gttcgacgtg 240
atcattcgct gctttaaacg ccatggtgcc gaagtgattg ataccccggt gtttgagctg 300
aaagagacac tgatgggcaa atatggtgag gacagcaaac tgctcgag              348

<210> 47
<211> 819
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 47
ggatccgcag aacgtgccgc cctggaagag ctggtaaaac tgcaaggcga gcgtgttcgt 60
ggtctgaaac agcagaaagc aagcgctgaa ctgatcgaag aagaagtggc gaaactgctg 120
aaactgaaag cacagctggg tcctgatgaa tcaaaacaaa aattcgtcct gaaaactccg 180
aaaggaaccc gtgactattc tcctcgtcaa atggccgtcc gtgaaaaagt gttcgacgtg 240
atcattcgct gctttaaacg ccatggtgcc gaagtgattg ataccccggt gtttgagctg 300
aaagagacac tgatgggcaa atatggtgag gacagcaaac tgatctatga cctgaaagac 360
caaggcggtg aactgctgtc cctgcgttat gatctgactg tgccgtttgc ccgttatctg 420
gccatgaata aactgacgaa cattaaacgc tatcacattg ccaaagtgta tcgccgtgac 480
aatcctgcta tgactcgtgg acgttatcgt gaattctatc agtgtgactt cgatattgcc 540
ggcaacttcg accctatgat tccggatgct gaatgcctga aaatcatgtg tgagatcctg 600
agcagcctgc aaattggtga cttcctggtg aaagtgaatg accgtcgtat cctggatggc 660
atgtttgcca tttgtggtgt gagcgattcc aaattccgta ccatctgtag tagtgtggac 720
aaactggata aagtgggcta tccgtggtgg aactcttgta gccgtattct gaactatcct 780
aaaaccagcc gcccgtggcg tgcttgggaa actctcgag                        819

<210> 48
<211> 395
<212> PRT
<213> Homo sapiens

<400> 48
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Asp Phe Asp Ile
    50                  55                  60                  
Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile
65                  70                  75                  80  
Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val Lys
                85                  90                  95      
Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val
            100                 105                 110         
Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp
        115                 120                 125             
Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly
    130                 135                 140                 
Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His
145                 150                 155                 160 
Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser
                165                 170                 175     
Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe
            180                 185                 190         
Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu
        195                 200                 205             
Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala
    210                 215                 220                 
Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val
225                 230                 235                 240 
Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe
                245                 250                 255     
Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val
            260                 265                 270         
Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu
        275                 280                 285             
Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys
    290                 295                 300                 
Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala
305                 310                 315                 320 
Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn
                325                 330                 335     
Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile
            340                 345                 350         
Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr
        355                 360                 365             
Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile
    370                 375                 380                 
Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys
385                 390                 395 


<210> 49
<211> 1188
<212> DNA
<213> Homo sapiens

<400> 49
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
gattttgaca ttgctgggaa ctttgatccc atgatccctg atgcagagtg cctgaagatc 240
atgtgcgaga tcctgagttc acttcagata ggcgacttcc tggtcaaggt aaacgatcga 300
cgcattctag atgggatgtt tgctatctgt ggtgtttctg acagcaagtt ccgtaccatc 360
tgctcctcag tagacaagct ggacaaggtg tcctgggaag aggtgaagaa tgagatggtg 420
ggagagaagg gccttgcacc tgaggtggct gaccgcattg gggactatgt ccagcaacat 480
ggtggggtat ccctggtgga acagctgctc caggatccta aactatccca aaacaagcag 540
gccttggagg gcctgggaga cctgaagttg ctctttgagt acctgaccct atttggcatt 600
gatgacaaaa tctcctttga cctgagcctt gctcgagggc tggattacta cactggggtg 660
atctatgagg cagtgctgct acagacccca gcccaggcag gggaagagcc cctgggtgtg 720
ggcagtgtgg ctgctggagg acgctatgat gggctagtgg gcatgttcga ccccaaaggg 780
cgcaaggtgc catgtgtggg gctcagcatt ggggtggagc ggattttctc catcgtggaa 840
cagagactag aggctttgga ggagaagata cggaccacgg agacacaggt gcttgtggca 900
tctgcacaga agaagctgct agaggaaaga ctaaagcttg tctcagaact gtgggatgct 960
gggatcaagg ctgagctgct gtacaagaag aacccaaagc tactgaacca gttacagtac 1020
tgtgaggagg caggcatccc actggtggct atcatcggcg agcaggaact caaggatggg 1080
gtcatcaagc tccgttcagt gacgagcagg gaagaggtgg atgtccgaag agaagacctt 1140
gtggaggaaa tcaaaaggag aacaggccag cccctctgca tctgctga              1188

<210> 50
<211> 359
<212> PRT
<213> Homo sapiens

<400> 50
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Val Asn Asp Arg
    50                  55                  60                  
Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys
65                  70                  75                  80  
Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp
                85                  90                  95      
Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu
            100                 105                 110         
Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser
        115                 120                 125             
Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln
    130                 135                 140                 
Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr
145                 150                 155                 160 
Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg
                165                 170                 175     
Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln
            180                 185                 190         
Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala
        195                 200                 205             
Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly
    210                 215                 220                 
Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe
225                 230                 235                 240 
Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr
                245                 250                 255     
Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu
            260                 265                 270         
Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala
        275                 280                 285             
Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr
    290                 295                 300                 
Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu
305                 310                 315                 320 
Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu
                325                 330                 335     
Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr
            340                 345                 350         
Gly Gln Pro Leu Cys Ile Cys
        355                 


<210> 51
<211> 1080
<212> DNA
<213> Homo sapiens

<400> 51
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
gtaaacgatc gacgcattct agatgggatg tttgctatct gtggtgtttc tgacagcaag 240
ttccgtacca tctgctcctc agtagacaag ctggacaagg tgtcctggga agaggtgaag 300
aatgagatgg tgggagagaa gggccttgca cctgaggtgg ctgaccgcat tggggactat 360
gtccagcaac atggtggggt atccctggtg gaacagctgc tccaggatcc taaactatcc 420
caaaacaagc aggccttgga gggcctggga gacctgaagt tgctctttga gtacctgacc 480
ctatttggca ttgatgacaa aatctccttt gacctgagcc ttgctcgagg gctggattac 540
tacactgggg tgatctatga ggcagtgctg ctacagaccc cagcccaggc aggggaagag 600
cccctgggtg tgggcagtgt ggctgctgga ggacgctatg atgggctagt gggcatgttc 660
gaccccaaag ggcgcaaggt gccatgtgtg gggctcagca ttggggtgga gcggattttc 720
tccatcgtgg aacagagact agaggctttg gaggagaaga tacggaccac ggagacacag 780
gtgcttgtgg catctgcaca gaagaagctg ctagaggaaa gactaaagct tgtctcagaa 840
ctgtgggatg ctgggatcaa ggctgagctg ctgtacaaga agaacccaaa gctactgaac 900
cagttacagt actgtgagga ggcaggcatc ccactggtgg ctatcatcgg cgagcaggaa 960
ctcaaggatg gggtcatcaa gctccgttca gtgacgagca gggaagaggt ggatgtccga 1020
agagaagacc ttgtggagga aatcaaaagg agaacaggcc agcccctctg catctgctga 1080


<210> 52
<211> 399
<212> PRT
<213> Homo sapiens

<400> 52
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp
    50                  55                  60                  
Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile
65                  70                  75                  80  
Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val
                85                  90                  95      
Phe Glu Leu Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala
            100                 105                 110         
Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val
        115                 120                 125             
Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val
    130                 135                 140                 
Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr
145                 150                 155                 160 
Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp
                165                 170                 175     
Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu
            180                 185                 190         
Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile
        195                 200                 205             
Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val
    210                 215                 220                 
Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu
225                 230                 235                 240 
Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu
                245                 250                 255     
Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu
            260                 265                 270         
Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu
        275                 280                 285             
Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala
    290                 295                 300                 
Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu
305                 310                 315                 320 
Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro
                325                 330                 335     
Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu
            340                 345                 350         
Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu
        355                 360                 365             
Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu
    370                 375                 380                 
Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys
385                 390                 395                 


<210> 53
<211> 1200
<212> DNA
<213> Homo sapiens

<400> 53
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc 240
atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag 300
gtaaacgatc gacgcattct agatgggatg tttgctatct gtggtgtttc tgacagcaag 360
ttccgtacca tctgctcctc agtagacaag ctggacaagg tgtcctggga agaggtgaag 420
aatgagatgg tgggagagaa gggccttgca cctgaggtgg ctgaccgcat tggggactat 480
gtccagcaac atggtggggt atccctggtg gaacagctgc tccaggatcc taaactatcc 540
caaaacaagc aggccttgga gggcctggga gacctgaagt tgctctttga gtacctgacc 600
ctatttggca ttgatgacaa aatctccttt gacctgagcc ttgctcgagg gctggattac 660
tacactgggg tgatctatga ggcagtgctg ctacagaccc cagcccaggc aggggaagag 720
cccctgggtg tgggcagtgt ggctgctgga ggacgctatg atgggctagt gggcatgttc 780
gaccccaaag ggcgcaaggt gccatgtgtg gggctcagca ttggggtgga gcggattttc 840
tccatcgtgg aacagagact agaggctttg gaggagaaga tacggaccac ggagacacag 900
gtgcttgtgg catctgcaca gaagaagctg ctagaggaaa gactaaagct tgtctcagaa 960
ctgtgggatg ctgggatcaa ggctgagctg ctgtacaaga agaacccaaa gctactgaac 1020
cagttacagt actgtgagga ggcaggcatc ccactggtgg ctatcatcgg cgagcaggaa 1080
ctcaaggatg gggtcatcaa gctccgttca gtgacgagca gggaagaggt ggatgtccga 1140
agagaagacc ttgtggagga aatcaaaagg agaacaggcc agcccctctg catctgctga 1200


<210> 54
<211> 473
<212> PRT
<213> Homo sapiens

<400> 54
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp
    50                  55                  60                  
Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile
65                  70                  75                  80  
Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val
                85                  90                  95      
Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys
            100                 105                 110         
Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg
        115                 120                 125             
Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu
    130                 135                 140                 
Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn
145                 150                 155                 160 
Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Val Asn
                165                 170                 175     
Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp
            180                 185                 190         
Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val
        195                 200                 205             
Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala
    210                 215                 220                 
Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly
225                 230                 235                 240 
Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn
                245                 250                 255     
Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr
            260                 265                 270         
Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu
        275                 280                 285             
Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu
    290                 295                 300                 
Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser
305                 310                 315                 320 
Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro
                325                 330                 335     
Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg
            340                 345                 350         
Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile
        355                 360                 365             
Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu
    370                 375                 380                 
Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile
385                 390                 395                 400 
Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu
                405                 410                 415     
Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu
            420                 425                 430         
Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg
        435                 440                 445             
Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg
    450                 455                 460                 
Arg Thr Gly Gln Pro Leu Cys Ile Cys
465                 470             


<210> 55
<211> 1422
<212> DNA
<213> Homo sapiens

<400> 55
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc 240
atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag 300
gaaacactga tgggaaagta tggggaagac tccaagctta tctatgacct gaaggaccag 360
ggcggggagc tcctgtccct tcgctatgac ctcactgttc cttttgctcg gtatttggca 420
atgaataaac tgaccaacat taaacgctac cacatagcaa aggtatatcg gcgggataac 480
ccagccatga cccgtggccg ataccgggaa ttctaccagt gtgtaaacga tcgacgcatt 540
ctagatggga tgtttgctat ctgtggtgtt tctgacagca agttccgtac catctgctcc 600
tcagtagaca agctggacaa ggtgtcctgg gaagaggtga agaatgagat ggtgggagag 660
aagggccttg cacctgaggt ggctgaccgc attggggact atgtccagca acatggtggg 720
gtatccctgg tggaacagct gctccaggat cctaaactat cccaaaacaa gcaggccttg 780
gagggcctgg gagacctgaa gttgctcttt gagtacctga ccctatttgg cattgatgac 840
aaaatctcct ttgacctgag ccttgctcga gggctggatt actacactgg ggtgatctat 900
gaggcagtgc tgctacagac cccagcccag gcaggggaag agcccctggg tgtgggcagt 960
gtggctgctg gaggacgcta tgatgggcta gtgggcatgt tcgaccccaa agggcgcaag 1020
gtgccatgtg tggggctcag cattggggtg gagcggattt tctccatcgt ggaacagaga 1080
ctagaggctt tggaggagaa gatacggacc acggagacac aggtgcttgt ggcatctgca 1140
cagaagaagc tgctagagga aagactaaag cttgtctcag aactgtggga tgctgggatc 1200
aaggctgagc tgctgtacaa gaagaaccca aagctactga accagttaca gtactgtgag 1260
gaggcaggca tcccactggt ggctatcatc ggcgagcagg aactcaagga tggggtcatc 1320
aagctccgtt cagtgacgag cagggaagag gtggatgtcc gaagagaaga ccttgtggag 1380
gaaatcaaaa ggagaacagg ccagcccctc tgcatctgct ga                    1422

<210> 56
<211> 469
<212> PRT
<213> Homo sapiens

<400> 56
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Glu Thr Leu Met
    50                  55                  60                  
Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln
65                  70                  75                  80  
Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala
                85                  90                  95      
Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr His Ile
            100                 105                 110         
Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr
        115                 120                 125             
Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro
    130                 135                 140                 
Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser
145                 150                 155                 160 
Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile
                165                 170                 175     
Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg
            180                 185                 190         
Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu
        195                 200                 205             
Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala
    210                 215                 220                 
Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val
225                 230                 235                 240 
Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu
                245                 250                 255     
Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe
            260                 265                 270         
Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu
        275                 280                 285             
Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro
    290                 295                 300                 
Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly
305                 310                 315                 320 
Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys
                325                 330                 335     
Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile
            340                 345                 350         
Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu
        355                 360                 365             
Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg
    370                 375                 380                 
Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu
385                 390                 395                 400 
Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu
                405                 410                 415     
Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys
            420                 425                 430         
Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp
        435                 440                 445             
Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln
    450                 455                 460                 
Pro Leu Cys Ile Cys
465                 


<210> 57
<211> 1410
<212> DNA
<213> Homo sapiens

<400> 57
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
gaaacactga tgggaaagta tggggaagac tccaagctta tctatgacct gaaggaccag 240
ggcggggagc tcctgtccct tcgctatgac ctcactgttc cttttgctcg gtatttggca 300
atgaataaac tgaccaacat taaacgctac cacatagcaa aggtatatcg gcgggataac 360
ccagccatga cccgtggccg ataccgggaa ttctaccagt gtgattttga cattgctggg 420
aactttgatc ccatgatccc tgatgcagag tgcctgaaga tcatgtgcga gatcctgagt 480
tcacttcaga taggcgactt cctggtcaag gtaaacgatc gacgcattct agatgggatg 540
tttgctatct gtggtgtttc tgacagcaag ttccgtacca tctgctcctc agtagacaag 600
ctggacaagg tgtcctggga agaggtgaag aatgagatgg tgggagagaa gggccttgca 660
cctgaggtgg ctgaccgcat tggggactat gtccagcaac atggtggggt atccctggtg 720
gaacagctgc tccaggatcc taaactatcc caaaacaagc aggccttgga gggcctggga 780
gacctgaagt tgctctttga gtacctgacc ctatttggca ttgatgacaa aatctccttt 840
gacctgagcc ttgctcgagg gctggattac tacactgggg tgatctatga ggcagtgctg 900
ctacagaccc cagcccaggc aggggaagag cccctgggtg tgggcagtgt ggctgctgga 960
ggacgctatg atgggctagt gggcatgttc gaccccaaag ggcgcaaggt gccatgtgtg 1020
gggctcagca ttggggtgga gcggattttc tccatcgtgg aacagagact agaggctttg 1080
gaggagaaga tacggaccac ggagacacag gtgcttgtgg catctgcaca gaagaagctg 1140
ctagaggaaa gactaaagct tgtctcagaa ctgtgggatg ctgggatcaa ggctgagctg 1200
ctgtacaaga agaacccaaa gctactgaac cagttacagt actgtgagga ggcaggcatc 1260
ccactggtgg ctatcatcgg cgagcaggaa ctcaaggatg gggtcatcaa gctccgttca 1320
gtgacgagca gggaagaggt ggatgtccga agagaagacc ttgtggagga aatcaaaagg 1380
agaacaggcc agcccctctg catctgctga                                  1410

<210> 58
<211> 435
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp
    50                  55                  60                  
Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile
65                  70                  75                  80  
Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val
                85                  90                  95      
Phe Glu Leu Lys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile
            100                 105                 110         
Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu
        115                 120                 125             
Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp
    130                 135                 140                 
Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile
145                 150                 155                 160 
Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys
                165                 170                 175     
Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg
            180                 185                 190         
Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln
        195                 200                 205             
Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly
    210                 215                 220                 
Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile
225                 230                 235                 240 
Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr
                245                 250                 255     
Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln
            260                 265                 270         
Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg
        275                 280                 285             
Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro
    290                 295                 300                 
Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu
305                 310                 315                 320 
Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln
                325                 330                 335     
Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys
            340                 345                 350         
Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr
        355                 360                 365             
Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala
    370                 375                 380                 
Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly
385                 390                 395                 400 
Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg
                405                 410                 415     
Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu
            420                 425                 430         
Cys Ile Cys
        435 


<210> 59
<211> 1308
<212> DNA
<213> Homo sapiens

<400> 59
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc 240
atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag 300
gattttgaca ttgctgggaa ctttgatccc atgatccctg atgcagagtg cctgaagatc 360
atgtgcgaga tcctgagttc acttcagata ggcgacttcc tggtcaaggt aaacgatcga 420
cgcattctag atgggatgtt tgctatctgt ggtgtttctg acagcaagtt ccgtaccatc 480
tgctcctcag tagacaagct ggacaaggtg tcctgggaag aggtgaagaa tgagatggtg 540
ggagagaagg gccttgcacc tgaggtggct gaccgcattg gggactatgt ccagcaacat 600
ggtggggtat ccctggtgga acagctgctc caggatccta aactatccca aaacaagcag 660
gccttggagg gcctgggaga cctgaagttg ctctttgagt acctgaccct atttggcatt 720
gatgacaaaa tctcctttga cctgagcctt gctcgagggc tggattacta cactggggtg 780
atctatgagg cagtgctgct acagacccca gcccaggcag gggaagagcc cctgggtgtg 840
ggcagtgtgg ctgctggagg acgctatgat gggctagtgg gcatgttcga ccccaaaggg 900
cgcaaggtgc catgtgtggg gctcagcatt ggggtggagc ggattttctc catcgtggaa 960
cagagactag aggctttgga ggagaagata cggaccacgg agacacaggt gcttgtggca 1020
tctgcacaga agaagctgct agaggaaaga ctaaagcttg tctcagaact gtgggatgct 1080
gggatcaagg ctgagctgct gtacaagaag aacccaaagc tactgaacca gttacagtac 1140
tgtgaggagg caggcatccc actggtggct atcatcggcg agcaggaact caaggatggg 1200
gtcatcaagc tccgttcagt gacgagcagg gaagaggtgg atgtccgaag agaagacctt 1260
gtggaggaaa tcaaaaggag aacaggccag cccctctgca tctgctga              1308

<210> 60
<211> 171
<212> PRT
<213> Homo sapiens

<400> 60
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Ala Leu Glu Glu
    50                  55                  60                  
Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys
65                  70                  75                  80  
Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala
                85                  90                  95      
Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn
            100                 105                 110         
Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile
        115                 120                 125             
Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr
    130                 135                 140                 
Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile
145                 150                 155                 160 
Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys
                165                 170     


<210> 61
<211> 516
<212> DNA
<213> Homo sapiens

<400> 61
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
gctttggagg agaagatacg gaccacggag acacaggtgc ttgtggcatc tgcacagaag 240
aagctgctag aggaaagact aaagcttgtc tcagaactgt gggatgctgg gatcaaggct 300
gagctgctgt acaagaagaa cccaaagcta ctgaaccagt tacagtactg tgaggaggca 360
ggcatcccac tggtggctat catcggcgag caggaactca aggatggggt catcaagctc 420
cgttcagtga cgagcaggga agaggtggat gtccgaagag aagaccttgt ggaggaaatc 480
aaaaggagaa caggccagcc cctctgcatc tgctga                           516

<210> 62
<211> 211
<212> PRT
<213> Homo sapiens

<400> 62
Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu
 1               5                  10                  15      
Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu
            20                  25                  30          
Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp
        35                  40                  45              
Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp
    50                  55                  60                  
Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile
65                  70                  75                  80  
Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val
                85                  90                  95      
Phe Glu Leu Lys Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln
            100                 105                 110         
Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys
        115                 120                 125             
Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr
    130                 135                 140                 
Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala
145                 150                 155                 160 
Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly
                165                 170                 175     
Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg
            180                 185                 190         
Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu
        195                 200                 205             
Cys Ile Cys
    210     


<210> 63
<211> 636
<212> DNA
<213> Homo sapiens

<400> 63
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc 60
ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa 120
ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag 180
ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc 240
atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag 300
gctttggagg agaagatacg gaccacggag acacaggtgc ttgtggcatc tgcacagaag 360
aagctgctag aggaaagact aaagcttgtc tcagaactgt gggatgctgg gatcaaggct 420
gagctgctgt acaagaagaa cccaaagcta ctgaaccagt tacagtactg tgaggaggca 480
ggcatcccac tggtggctat catcggcgag caggaactca aggatggggt catcaagctc 540
cgttcagtga cgagcaggga agaggtggat gtccgaagag aagaccttgt ggaggaaatc 600
aaaaggagaa caggccagcc cctctgcatc tgctga                           636

<210> 64
<211> 141
<212> PRT
<213> Homo sapiens

<400> 64
Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile
 1               5                  10                  15      
Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu
            20                  25                  30          
Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala
        35                  40                  45              
Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp
    50                  55                  60                  
Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu
65                  70                  75                  80  
Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala
                85                  90                  95      
Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser
            100                 105                 110         
Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu
        115                 120                 125             
Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys
    130                 135                 140     


<210> 65
<211> 426
<212> DNA
<213> Homo sapiens

<400> 65
atgttcgacc ccaaagggcg caaggtgcca tgtgtggggc tcagcattgg ggtggagcgg 60
attttctcca tcgtggaaca gagactagag gctttggagg agaagatacg gaccacggag 120
acacaggtgc ttgtggcatc tgcacagaag aagctgctag aggaaagact aaagcttgtc 180
tcagaactgt gggatgctgg gatcaaggct gagctgctgt acaagaagaa cccaaagcta 240
ctgaaccagt tacagtactg tgaggaggca ggcatcccac tggtggctat catcggcgag 300
caggaactca aggatggggt catcaagctc cgttcagtga cgagcaggga agaggtggat 360
gtccgaagag aagaccttgt ggaggaaatc aaaaggagaa caggccagcc cctctgcatc 420
tgctga                                                            426

<210> 66
<211> 50
<212> DNA
<213> Homo sapiens

<400> 66
gaaatttgtg ctcaaaaccc ccaaggattt tgacattgct gggaactttg            50

<210> 67
<211> 16
<212> PRT
<213> Homo sapiens

<400> 67
Lys Phe Val Leu Lys Thr Pro Lys Asp Phe Asp Ile Ala Gly Asn Phe
 1               5                  10                  15      


<210> 68
<211> 50
<212> DNA
<213> Homo sapiens

<400> 68
gaaatttgtg ctcaaaaccc ccaaggtaaa cgatcgacgc attctagatg            50

<210> 69
<211> 16
<212> PRT
<213> Homo sapiens

<400> 69
Lys Phe Val Leu Lys Thr Pro Lys Val Asn Asp Arg Arg Ile Leu Asp
 1               5                  10                  15      


<210> 70
<211> 50
<212> DNA
<213> Homo sapiens

<400> 70
tgatacacct gtatttgaac taaaggtaaa cgatcgacgc attctagatg            50

<210> 71
<211> 16
<212> PRT
<213> Homo sapiens

<400> 71
Asp Thr Pro Val Phe Glu Leu Lys Val Asn Asp Arg Arg Ile Leu Asp
 1               5                  10                  15      


<210> 72
<211> 50
<212> DNA
<213> Homo sapiens

<400> 72
ccgataccgg gaattctacc agtgtgtaaa cgatcgacgc attctagatg            50

<210> 73
<211> 16
<212> PRT
<213> Homo sapiens

<400> 73
Arg Tyr Arg Glu Phe Tyr Gln Cys Val Asn Asp Arg Arg Ile Leu Asp
 1               5                  10                  15      


<210> 74
<211> 50
<212> DNA
<213> Homo sapiens

<400> 74
gaaatttgtg ctcaaaaccc ccaaggaaac actgatggga aagtatgggg            50

<210> 75
<211> 16
<212> PRT
<213> Homo sapiens

<400> 75
Lys Phe Val Leu Lys Thr Pro Lys Glu Thr Leu Met Gly Lys Tyr Gly
 1               5                  10                  15      


<210> 76
<211> 50
<212> DNA
<213> Homo sapiens

<400> 76
tgatacacct gtatttgaac taaaggattt tgacattgct gggaactttg            50

<210> 77
<211> 16
<212> PRT
<213> Homo sapiens

<400> 77
Asp Thr Pro Val Phe Glu Leu Lys Asp Phe Asp Ile Ala Gly Asn Phe
 1               5                  10                  15      


<210> 78
<211> 50
<212> DNA
<213> Homo sapiens

<400> 78
gaaatttgtg ctcaaaaccc ccaaggcttt ggaggagaag atacggacca            50

<210> 79
<211> 16
<212> PRT
<213> Homo sapiens

<400> 79
Lys Phe Val Leu Lys Thr Pro Lys Ala Leu Glu Glu Lys Ile Arg Thr
 1               5                  10                  15      


<210> 80
<211> 50
<212> DNA
<213> Homo sapiens

<400> 80
tgatacacct gtatttgaac taaaggcttt ggaggagaag atacggacca            50

<210> 81
<211> 16
<212> PRT
<213> Homo sapiens

<400> 81
Asp Thr Pro Val Phe Glu Leu Lys Ala Leu Glu Glu Lys Ile Arg Thr
 1               5                  10                  15      


<210> 82
<211> 50
<212> DNA
<213> Homo sapiens

<400> 82
ctcctcagta gacaagctgg acaaggtggg gtatccctgg tggaacagct            50

<210> 83
<211> 105
<212> PRT
<213> Homo sapiens

<400> 83
Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu
 1               5                  10                  15      
Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile
            20                  25                  30          
Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu
        35                  40                  45              
Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu
    50                  55                  60                  
Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg
65                  70                  75                  80  
Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg
                85                  90                  95      
Arg Thr Gly Gln Pro Leu Cys Ile Cys
            100                 105 


<210> 84
<211> 318
<212> DNA
<213> Homo sapiens

<400> 84
cggaccacgg agacacaggt gcttgtggca tctgcacaga agaagctgct agaggaaaga 60
ctaaagcttg tctcagaact gtgggatgct gggatcaagg ctgagctgct gtacaagaag 120
aacccaaagc tactgaacca gttacagtac tgtgaggagg caggcatccc actggtggct 180
atcatcggcg agcaggaact caaggatggg gtcatcaagc tccgttcagt gacgagcagg 240
gaagaggtgg atgtccgaag agaagacctt gtggaggaaa tcaaaaggag aacaggccag 300
cccctctgca tctgctga                                               318

<210> 85
<211> 130
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 85
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Arg Thr Thr Glu Thr Gln Val Leu Val
            20                  25                  30          
Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser
        35                  40                  45              
Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn
    50                  55                  60                  
Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro
65                  70                  75                  80  
Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys
                85                  90                  95      
Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp
            100                 105                 110         
Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys
        115                 120                 125             
Leu Glu
    130 


<210> 86
<211> 130
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 86
Met Gly Ser Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln
 1               5                  10                  15      
Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp
            20                  25                  30          
Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu
        35                  40                  45              
Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile
    50                  55                  60                  
Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val
65                  70                  75                  80  
Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu
                85                  90                  95      
Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys Leu Glu Gly Lys
            100                 105                 110         
Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His
        115                 120                 125             
His His
    130 


<210> 87
<211> 419
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 87
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu
            20                  25                  30          
Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala
        35                  40                  45              
Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys
    50                  55                  60                  
Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr
65                  70                  75                  80  
Pro Lys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp
                85                  90                  95      
Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile
            100                 105                 110         
Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met
        115                 120                 125             
Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser
    130                 135                 140                 
Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu
145                 150                 155                 160 
Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly
                165                 170                 175     
Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu
            180                 185                 190         
Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly
        195                 200                 205             
Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp
    210                 215                 220                 
Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr
225                 230                 235                 240 
Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly
                245                 250                 255     
Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp
            260                 265                 270         
Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val
        275                 280                 285             
Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg
    290                 295                 300                 
Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu
305                 310                 315                 320 
Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val
                325                 330                 335     
Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys
            340                 345                 350         
Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile
        355                 360                 365             
Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile
    370                 375                 380                 
Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu
385                 390                 395                 400 
Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile
                405                 410                 415     
Cys Leu Glu
            


<210> 88
<211> 419
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 88
Met Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln
 1               5                  10                  15      
Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu
            20                  25                  30          
Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly
        35                  40                  45              
Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Asp Phe
    50                  55                  60                  
Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu
65                  70                  75                  80  
Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu
                85                  90                  95      
Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys
            100                 105                 110         
Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys
        115                 120                 125             
Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu
    130                 135                 140                 
Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln
145                 150                 155                 160 
Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys
                165                 170                 175     
Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu
            180                 185                 190         
Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe
        195                 200                 205             
Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr
    210                 215                 220                 
Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu
225                 230                 235                 240 
Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly
                245                 250                 255     
Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile
            260                 265                 270         
Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu
        275                 280                 285             
Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala
    290                 295                 300                 
Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp
305                 310                 315                 320 
Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu
                325                 330                 335     
Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala
            340                 345                 350         
Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser
        355                 360                 365             
Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu
    370                 375                 380                 
Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys Leu Glu Gly
385                 390                 395                 400 
Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His
                405                 410                 415     
His His His
            


<210> 89
<211> 383
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 89
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu
            20                  25                  30          
Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala
        35                  40                  45              
Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys
    50                  55                  60                  
Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr
65                  70                  75                  80  
Pro Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys
                85                  90                  95      
Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys
            100                 105                 110         
Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu
        115                 120                 125             
Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln
    130                 135                 140                 
Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys
145                 150                 155                 160 
Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu
                165                 170                 175     
Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe
            180                 185                 190         
Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr
        195                 200                 205             
Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu
    210                 215                 220                 
Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly
225                 230                 235                 240 
Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile
                245                 250                 255     
Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu
            260                 265                 270         
Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala
        275                 280                 285             
Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp
    290                 295                 300                 
Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu
305                 310                 315                 320 
Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala
                325                 330                 335     
Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser
            340                 345                 350         
Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu
        355                 360                 365             
Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys Leu Glu
    370                 375                 380             


<210> 90
<211> 383
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 90
Met Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln
 1               5                  10                  15      
Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu
            20                  25                  30          
Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly
        35                  40                  45              
Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Val Asn
    50                  55                  60                  
Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp
65                  70                  75                  80  
Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val
                85                  90                  95      
Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala
            100                 105                 110         
Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly
        115                 120                 125             
Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn
    130                 135                 140                 
Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr
145                 150                 155                 160 
Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu
                165                 170                 175     
Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu
            180                 185                 190         
Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser
        195                 200                 205             
Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro
    210                 215                 220                 
Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg
225                 230                 235                 240 
Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile
                245                 250                 255     
Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu
            260                 265                 270         
Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile
        275                 280                 285             
Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu
    290                 295                 300                 
Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu
305                 310                 315                 320 
Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg
                325                 330                 335     
Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg
            340                 345                 350         
Arg Thr Gly Gln Pro Leu Cys Ile Cys Leu Glu Gly Lys Pro Ile Pro
        355                 360                 365             
Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
    370                 375                 380             


<210> 91
<211> 423
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 91
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu
            20                  25                  30          
Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala
        35                  40                  45              
Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys
    50                  55                  60                  
Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr
65                  70                  75                  80  
Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu
                85                  90                  95      
Lys Val Phe Asp Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu
            100                 105                 110         
Val Ile Asp Thr Pro Val Phe Glu Leu Lys Val Asn Asp Arg Arg Ile
        115                 120                 125             
Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg
    130                 135                 140                 
Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu
145                 150                 155                 160 
Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala
                165                 170                 175     
Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val
            180                 185                 190         
Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu
        195                 200                 205             
Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe
    210                 215                 220                 
Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu
225                 230                 235                 240 
Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro
                245                 250                 255     
Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly
            260                 265                 270         
Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys
        275                 280                 285             
Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile
    290                 295                 300                 
Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu
305                 310                 315                 320 
Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg
                325                 330                 335     
Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu
            340                 345                 350         
Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu
        355                 360                 365             
Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys
    370                 375                 380                 
Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp
385                 390                 395                 400 
Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln
                405                 410                 415     
Pro Leu Cys Ile Cys Leu Glu
            420             


<210> 92
<211> 423
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 92
Met Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln
 1               5                  10                  15      
Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu
            20                  25                  30          
Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly
        35                  40                  45              
Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr
    50                  55                  60                  
Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp
65                  70                  75                  80  
Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr
                85                  90                  95      
Pro Val Phe Glu Leu Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met
            100                 105                 110         
Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser
        115                 120                 125             
Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu
    130                 135                 140                 
Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly
145                 150                 155                 160 
Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu
                165                 170                 175     
Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly
            180                 185                 190         
Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp
        195                 200                 205             
Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr
    210                 215                 220                 
Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly
225                 230                 235                 240 
Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp
                245                 250                 255     
Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val
            260                 265                 270         
Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg
        275                 280                 285             
Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu
    290                 295                 300                 
Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val
305                 310                 315                 320 
Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys
                325                 330                 335     
Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile
            340                 345                 350         
Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile
        355                 360                 365             
Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu
    370                 375                 380                 
Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile
385                 390                 395                 400 
Cys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser
                405                 410                 415     
Thr His His His His His His
            420             


<210> 93
<211> 497
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 93
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu
            20                  25                  30          
Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala
        35                  40                  45              
Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys
    50                  55                  60                  
Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr
65                  70                  75                  80  
Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu
                85                  90                  95      
Lys Val Phe Asp Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu
            100                 105                 110         
Val Ile Asp Thr Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys
        115                 120                 125             
Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly
    130                 135                 140                 
Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr
145                 150                 155                 160 
Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr His Ile Ala Lys
                165                 170                 175     
Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu
            180                 185                 190         
Phe Tyr Gln Cys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala
        195                 200                 205             
Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val
    210                 215                 220                 
Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val
225                 230                 235                 240 
Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr
                245                 250                 255     
Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp
            260                 265                 270         
Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu
        275                 280                 285             
Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile
    290                 295                 300                 
Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val
305                 310                 315                 320 
Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu
                325                 330                 335     
Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu
            340                 345                 350         
Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu
        355                 360                 365             
Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu
    370                 375                 380                 
Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala
385                 390                 395                 400 
Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu
                405                 410                 415     
Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro
            420                 425                 430         
Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu
        435                 440                 445             
Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu
    450                 455                 460                 
Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu
465                 470                 475                 480 
Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys Leu
                485                 490                 495     
Glu
    


<210> 94
<211> 497
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 94
Met Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln
 1               5                  10                  15      
Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu
            20                  25                  30          
Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly
        35                  40                  45              
Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr
    50                  55                  60                  
Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp
65                  70                  75                  80  
Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr
                85                  90                  95      
Pro Val Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp
            100                 105                 110         
Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser
        115                 120                 125             
Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn
    130                 135                 140                 
Lys Leu Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg
145                 150                 155                 160 
Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys
                165                 170                 175     
Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val
            180                 185                 190         
Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp
        195                 200                 205             
Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly
    210                 215                 220                 
Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His
225                 230                 235                 240 
Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser
                245                 250                 255     
Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe
            260                 265                 270         
Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu
        275                 280                 285             
Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala
    290                 295                 300                 
Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val
305                 310                 315                 320 
Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe
                325                 330                 335     
Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val
            340                 345                 350         
Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu
        355                 360                 365             
Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys
    370                 375                 380                 
Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala
385                 390                 395                 400 
Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn
                405                 410                 415     
Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile
            420                 425                 430         
Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr
        435                 440                 445             
Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile
    450                 455                 460                 
Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys Leu Glu Gly Lys Pro
465                 470                 475                 480 
Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His
                485                 490                 495     
His
    


<210> 95
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 95
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu
            20                  25                  30          
Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala
        35                  40                  45              
Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys
    50                  55                  60                  
Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr
65                  70                  75                  80  
Pro Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile
                85                  90                  95      
Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp
            100                 105                 110         
Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn
        115                 120                 125             
Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala
    130                 135                 140                 
Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile
145                 150                 155                 160 
Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile
                165                 170                 175     
Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val Lys
            180                 185                 190         
Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val
        195                 200                 205             
Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp
    210                 215                 220                 
Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly
225                 230                 235                 240 
Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His
                245                 250                 255     
Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser
            260                 265                 270         
Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe
        275                 280                 285             
Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu
    290                 295                 300                 
Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala
305                 310                 315                 320 
Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val
                325                 330                 335     
Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe
            340                 345                 350         
Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val
        355                 360                 365             
Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu
    370                 375                 380                 
Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys
385                 390                 395                 400 
Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala
                405                 410                 415     
Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn
            420                 425                 430         
Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile
        435                 440                 445             
Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr
    450                 455                 460                 
Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile
465                 470                 475                 480 
Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys Leu Glu
                485                 490             


<210> 96
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 96
Met Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln
 1               5                  10                  15      
Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu
            20                  25                  30          
Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly
        35                  40                  45              
Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Glu Thr
    50                  55                  60                  
Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys
65                  70                  75                  80  
Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro
                85                  90                  95      
Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr
            100                 105                 110         
His Ile Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly
        115                 120                 125             
Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe
    130                 135                 140                 
Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile
145                 150                 155                 160 
Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg
                165                 170                 175     
Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys
            180                 185                 190         
Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp
        195                 200                 205             
Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu
    210                 215                 220                 
Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser
225                 230                 235                 240 
Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln
                245                 250                 255     
Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr
            260                 265                 270         
Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg
        275                 280                 285             
Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln
    290                 295                 300                 
Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala
305                 310                 315                 320 
Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly
                325                 330                 335     
Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe
            340                 345                 350         
Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr
        355                 360                 365             
Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu
    370                 375                 380                 
Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala
385                 390                 395                 400 
Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr
                405                 410                 415     
Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu
            420                 425                 430         
Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu
        435                 440                 445             
Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr
    450                 455                 460                 
Gly Gln Pro Leu Cys Ile Cys Leu Glu Gly Lys Pro Ile Pro Asn Pro
465                 470                 475                 480 
Leu Leu Gly Leu Asp Ser Thr His His His His His His
                485                 490             


<210> 97
<211> 459
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 97
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu
            20                  25                  30          
Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala
        35                  40                  45              
Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys
    50                  55                  60                  
Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr
65                  70                  75                  80  
Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu
                85                  90                  95      
Lys Val Phe Asp Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu
            100                 105                 110         
Val Ile Asp Thr Pro Val Phe Glu Leu Lys Asp Phe Asp Ile Ala Gly
        115                 120                 125             
Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys
    130                 135                 140                 
Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn
145                 150                 155                 160 
Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp
                165                 170                 175     
Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val
            180                 185                 190         
Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala
        195                 200                 205             
Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly
    210                 215                 220                 
Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn
225                 230                 235                 240 
Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr
                245                 250                 255     
Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu
            260                 265                 270         
Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu
        275                 280                 285             
Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser
    290                 295                 300                 
Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro
305                 310                 315                 320 
Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg
                325                 330                 335     
Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile
            340                 345                 350         
Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu
        355                 360                 365             
Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile
    370                 375                 380                 
Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu
385                 390                 395                 400 
Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu
                405                 410                 415     
Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg
            420                 425                 430         
Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg
        435                 440                 445             
Arg Thr Gly Gln Pro Leu Cys Ile Cys Leu Glu
    450                 455                 


<210> 98
<211> 459
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 98
Met Gly Ser Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln
 1               5                  10                  15      
Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu
            20                  25                  30          
Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly
        35                  40                  45              
Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr
    50                  55                  60                  
Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp
65                  70                  75                  80  
Val Ile Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr
                85                  90                  95      
Pro Val Phe Glu Leu Lys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro
            100                 105                 110         
Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser
        115                 120                 125             
Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile
    130                 135                 140                 
Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg
145                 150                 155                 160 
Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu
                165                 170                 175     
Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala
            180                 185                 190         
Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val
        195                 200                 205             
Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu
    210                 215                 220                 
Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe
225                 230                 235                 240 
Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu
                245                 250                 255     
Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro
            260                 265                 270         
Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly
        275                 280                 285             
Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys
    290                 295                 300                 
Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile
305                 310                 315                 320 
Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu
                325                 330                 335     
Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg
            340                 345                 350         
Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu
        355                 360                 365             
Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu
    370                 375                 380                 
Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys
385                 390                 395                 400 
Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp
                405                 410                 415     
Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln
            420                 425                 430         
Pro Leu Cys Ile Cys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu
        435                 440                 445             
Gly Leu Asp Ser Thr His His His His His His
    450                 455                 


<210> 99
<211> 165
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 99
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Phe Asp Pro Lys Gly Arg Lys Val Pro
            20                  25                  30          
Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu
        35                  40                  45              
Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln
    50                  55                  60                  
Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys
65                  70                  75                  80  
Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr
                85                  90                  95      
Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala
            100                 105                 110         
Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly
        115                 120                 125             
Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg
    130                 135                 140                 
Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu
145                 150                 155                 160 
Cys Ile Cys Leu Glu
                165 


<210> 100
<211> 165
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 100
Met Gly Ser Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu
 1               5                  10                  15      
Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu
            20                  25                  30          
Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala
        35                  40                  45              
Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu
    50                  55                  60                  
Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro
65                  70                  75                  80  
Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu
                85                  90                  95      
Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu
            100                 105                 110         
Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu
        115                 120                 125             
Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys Leu
    130                 135                 140                 
Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His
145                 150                 155                 160 
His His His His His
                165 


<210> 101
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 101
ggatcccgta ccaccgaaac ccaagttctg gttgcctcag ctcagaaaaa actgctggaa 60
gaacgcctga aactggttag cgaactgtgg gatgctggca ttaaagccga actgctgtat 120
aaaaaaaacc cgaaactgct gaatcagctg cagtattgtg aggaagcggg tattcctctg 180
gtggccatta tcggagaaca ggaactgaaa gacggcgtta ttaaactgcg tagcgtgacc 240
tctcgtgaag aagttgacgt tcgccgtgaa gatctggtcg aggaaatcaa acgtcgtacc 300
ggtcaacctc tgtgtatttg cctcgag                                     327

<210> 102
<211> 1194
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 102
ggatccgcag aacgtgccgc cctggaagag ctggtaaaac tgcaaggcga gcgtgttcgt 60
ggtctgaaac agcagaaagc aagcgctgaa ctgatcgaag aagaagtggc gaaactgctg 120
aaactgaaag cacagctggg tcctgatgaa tcaaaacaaa aattcgtcct gaaaactccg 180
aaagacttcg atattgccgg gaattttgac cctatgatcc ctgatgccga atgtctgaaa 240
atcatgtgtg agatcctgag cagtctgcag attggtgact tcctggtgaa agtgaacgat 300
cgccgtattc tggatggaat gtttgccatt tgtggcgtgt ctgacagcaa atttcgtacg 360
atctgtagca gcgtggataa actggataaa gtgagctggg aggaggtgaa aaatgagatg 420
gtgggcgaaa aaggtctggc acctgaagtg gctgaccgta tcggtgatta tgttcagcaa 480
catggcggtg tttctctggt cgaacagctg ctgcaagacc caaaactgag ccagaacaaa 540
caggcactgg aaggactggg tgatctgaaa ctgctgtttg agtatctgac gctgtttggc 600
atcgatgaca aaatctcgtt tgacctgagc ctggcacgtg gtctggatta ttataccggc 660
gtgatctatg aagccgtcct gctgcaaact ccagcacaag caggtgaaga acctctgggt 720
gttggtagtg tagcggcagg cggacgttat gatggactgg tggggatgtt tgatccgaaa 780
ggccgtaaag ttccgtgtgt cggtctgagt atcggggttg agcgtatctt tagcattgtg 840
gagcaacgtc tggaagctct ggaggaaaaa atccgtacca ccgaaaccca agttctggtt 900
gcctcagctc agaaaaaact gctggaagaa cgcctgaaac tggttagcga actgtgggat 960
gctggcatta aagccgaact gctgtataaa aaaaacccga aactgctgaa tcagctgcag 1020
tattgtgagg aagcgggtat tcctctggtg gccattatcg gagaacagga actgaaagac 1080
ggcgttatta aactgcgtag cgtgacctct cgtgaagaag ttgacgttcg ccgtgaagat 1140
ctggtcgagg aaatcaaacg tcgtaccggt caacctctgt gtatttgcct cgag       1194

<210> 103
<211> 1086
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 103
ggatccgcag aacgtgccgc cctggaagag ctggtaaaac tgcaaggcga gcgtgttcgt 60
ggtctgaaac agcagaaagc aagcgctgaa ctgatcgaag aagaagtggc gaaactgctg 120
aaactgaaag cacagctggg tcctgatgaa tcaaaacaaa aattcgtcct gaaaactccg 180
aaagtgaatg atcgccgtat cctggatggc atgtttgcca tttgtggtgt gagcgactcg 240
aaattccgta cgatttgctc tagcgtcgat aaactggaca aagtgtcctg ggaagaggtg 300
aaaaacgaga tggtgggtga gaaaggtctg gctcctgaag ttgccgaccg tattggtgat 360
tatgttcagc agcatggcgg tgtttcactg gttgaacaac tgctgcaaga cccgaaactg 420
tctcagaata aacaggcgct ggaaggactg ggagatctga aactgctgtt tgagtatctg 480
accctgttcg gcattgatga caaaatcagc ttcgacctga gcctggcacg tggtctggat 540
tattataccg gcgtgatcta tgaagccgtt ctgctgcaga caccagcaca agcaggcgaa 600
gaacctctgg gtgttggttc tgtggcagcc ggtggtcgtt atgatggact ggtaggcatg 660
ttcgatccga aaggccgtaa agttccgtgt gtgggactga gtatcggtgt tgagcgtatc 720
tttagcatcg tggaacaacg tctggaagcg ctggaggaga aaattcgtac caccgaaacc 780
caagttctgg ttgcctcagc tcagaaaaaa ctgctggaag aacgcctgaa actggttagc 840
gaactgtggg atgctggcat taaagccgaa ctgctgtata aaaaaaaccc gaaactgctg 900
aatcagctgc agtattgtga ggaagcgggt attcctctgg tggccattat cggagaacag 960
gaactgaaag acggcgttat taaactgcgt agcgtgacct ctcgtgaaga agttgacgtt 1020
cgccgtgaag atctggtcga ggaaatcaaa cgtcgtaccg gtcaacctct gtgtatttgc 1080
ctcgag                                                            1086

<210> 104
<211> 1206
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 104
ggatccgcag aacgtgccgc cctggaagag ctggtaaaac tgcaaggcga gcgtgttcgt 60
ggtctgaaac agcagaaagc aagcgctgaa ctgatcgaag aagaagtggc gaaactgctg 120
aaactgaaag cacagctggg tcctgatgaa tcaaaacaaa aattcgtcct gaaaactccg 180
aaaggaactc gtgattatag ccctcgccag atggctgtcc gtgaaaaagt gttcgatgtg 240
atcattcgct gcttcaaacg tcatggtgcc gaagtcattg ataccccggt gttcgagctg 300
aaagtgaacg atcgccgtat tctggatggc atgttcgcca tttgtggtgt tagcgatagc 360
aaattccgta caatctgctc tagcgtggac aaactggaca aagtgagctg ggaagaggtg 420
aaaaacgaga tggtgggtga gaaaggcctg gctcctgaag ttgccgaccg tatcggagat 480
tatgttcagc agcatggcgg agtttcactg gttgaacaac tgctgcaaga cccgaaactg 540
tctcagaaca aacaggcact ggaaggtctg ggagatctga aactgctgtt cgagtatctg 600
acgctgttcg gtattgacga caaaatttcc ttcgacctgt cgctggcacg tggtctggat 660
tattatacag gcgtgatcta tgaggctgta ctgctgcaga caccagcaca agcaggtgaa 720
gagcctctgg gtgttggttc agttgctgcc ggtggacgtt atgacggact ggtagggatg 780
tttgacccaa aaggccgtaa agtcccgtgt gtaggactgt ctattggcgt tgagcgtatc 840
tttagcatcg tggagcaacg tctggaagct ctggaggaga aaatccgtac caccgaaacc 900
caagttctgg ttgcctcagc tcagaaaaaa ctgctggaag aacgcctgaa actggttagc 960
gaactgtggg atgctggcat taaagccgaa ctgctgtata aaaaaaaccc gaaactgctg 1020
aatcagctgc agtattgtga ggaagcgggt attcctctgg tggccattat cggagaacag 1080
gaactgaaag acggcgttat taaactgcgt agcgtgacct ctcgtgaaga agttgacgtt 1140
cgccgtgaag atctggtcga ggaaatcaaa cgtcgtaccg gtcaacctct gtgtatttgc 1200
ctcgag                                                            1206

<210> 105
<211> 1428
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 105
ggatccgcag aacgtgccgc cctggaagag ctggtaaaac tgcaaggcga gcgtgttcgt 60
ggtctgaaac agcagaaagc aagcgctgaa ctgatcgaag aagaagtggc gaaactgctg 120
aaactgaaag cacagctggg tcctgatgaa tcaaaacaaa aattcgtcct gaaaactccg 180
aaaggaactc gtgattatag ccctcgccag atggctgtcc gtgaaaaagt gttcgatgtg 240
atcattcgct gcttcaaacg tcatggtgcc gaagtcattg ataccccggt gttcgagctg 300
aaagaaaccc tgatgggcaa atatggggaa gattccaaac tgatctatga cctgaaagac 360
cagggaggtg aactgctgtc tctgcgctat gacctgactg ttccttttgc tcgctatctg 420
gccatgaata aactgaccaa catcaaacgc tatcatatcg ccaaagtgta tcgccgtgac 480
aatccagcaa tgacccgtgg tcgttatcgt gaattttatc agtgtgtgaa cgatcgccgt 540
attctggacg gcatgttcgc catttgtggt gtgtctgact ccaaatttcg tacgatctgc 600
tcaagcgtgg acaaactgga caaagtgagc tgggaagagg tgaaaaacga gatggtgggt 660
gagaaaggcc tggctcctga agttgccgac cgtatcggag attatgttca gcagcatggc 720
ggagtttcac tggttgaaca actgctgcaa gacccgaaac tgtcacagaa caaacaggca 780
ctggaaggtc tgggggatct gaaactgctg ttcgagtatc tgacgctgtt cggtattgac 840
gacaaaatca gcttcgatct gagcctggca cgtggtctgg actattatac cggcgtgatt 900
tatgaagccg ttctgctgca gactccagca caagcaggtg aagagcctct gggtgttgga 960
agtgtggcag ccggtggccg ttatgatggt ctggttggca tgtttgaccc gaaaggccgt 1020
aaagtcccgt gtgtaggact gtctatcggc gtggagcgta tttttagcat cgtggaacaa 1080
cgcctggaag ctctggaaga gaaaatccgt accaccgaaa cccaagttct ggttgcctca 1140
gctcagaaaa aactgctgga agaacgcctg aaactggtta gcgaactgtg ggatgctggc 1200
attaaagccg aactgctgta taaaaaaaac ccgaaactgc tgaatcagct gcagtattgt 1260
gaggaagcgg gtattcctct ggtggccatt atcggagaac aggaactgaa agacggcgtt 1320
attaaactgc gtagcgtgac ctctcgtgaa gaagttgacg ttcgccgtga agatctggtc 1380
gaggaaatca aacgtcgtac cggtcaacct ctgtgtattt gcctcgag              1428

<210> 106
<211> 1416
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 106
ggatccgcag aacgtgccgc cctggaagag ctggtaaaac tgcaaggcga gcgtgttcgt 60
ggtctgaaac agcagaaagc aagcgctgaa ctgatcgaag aagaagtggc gaaactgctg 120
aaactgaaag cacagctggg tcctgatgaa tcaaaacaaa aattcgtcct gaaaactccg 180
aaagaaaccc tgatgggcaa atatggcgaa gattccaaac tgatctatga cctgaaagac 240
caaggcggtg aactgctgtc cctgcgttat gacctgactg ttccgtttgc tcgttatctg 300
gccatgaata aactgaccaa cattaaacgc tatcacattg ccaaagtgta tcgccgtgac 360
aatcctgcta tgactcgtgg acgttatcgt gaattctatc agtgtgactt cgatattgcc 420
ggcaacttcg accctatgat tccggatgct gaatgcctga aaatcatgtg tgagatcctg 480
agcagcctgc aaattggtga cttcctggtg aaagtgaatg accgtcgtat cctggatggc 540
atgttcgcca tttgtggtgt tagcgattcc aaattccgta ccatctgtag tagtgtggac 600
aaactggata aagtgagctg ggaagaggtg aaaaacgaaa tggtgggcga aaaaggtctg 660
gcacctgagg ttgctgatcg tatcggtgac tatgtccagc agcatggagg tgtttcactg 720
gttgagcaac tgctgcaaga tccgaaactg tctcagaaca aacaggccct ggaaggactg 780
ggtgatctga aactgctgtt cgagtatctg acgctgttcg gtattgatga caaaatctcg 840
ttcgacctgt ctctggctcg tggactggat tattatacgg gcgtaatcta tgaagctgtc 900
ctgctgcaga caccagcaca agcaggtgaa gagcctctgg gtgttggaag tgttgctgcc 960
ggtggtcgct atgacggact ggttggcatg ttcgatccga aaggccgtaa agttccgtgt 1020
gtaggactga gcattggcgt tgagcgtatc ttttccatcg ttgagcaacg tctggaagca 1080
ctggaagaga aaatccgtac caccgaaacc caagttctgg ttgcctcagc tcagaaaaaa 1140
ctgctggaag aacgcctgaa actggttagc gaactgtggg atgctggcat taaagccgaa 1200
ctgctgtata aaaaaaaccc gaaactgctg aatcagctgc agtattgtga ggaagcgggt 1260
attcctctgg tggccattat cggagaacag gaactgaaag acggcgttat taaactgcgt 1320
agcgtgacct ctcgtgaaga agttgacgtt cgccgtgaag atctggtcga ggaaatcaaa 1380
cgtcgtaccg gtcaacctct gtgtatttgc ctcgag                           1416

<210> 107
<211> 1314
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 107
ggatccgcag aacgtgccgc cctggaagag ctggtaaaac tgcaaggcga gcgtgttcgt 60
ggtctgaaac agcagaaagc aagcgctgaa ctgatcgaag aagaagtggc gaaactgctg 120
aaactgaaag cacagctggg tcctgatgaa tcaaaacaaa aattcgtcct gaaaactccg 180
aaaggaactc gtgattatag ccctcgccag atggctgtcc gtgaaaaagt gttcgatgtg 240
atcattcgct gcttcaaacg tcatggtgcc gaagtcattg ataccccggt gttcgagctg 300
aaagatttcg atattgccgg caactttgat ccgatgattc cggatgctga gtgtctgaaa 360
atcatgtgtg agatcctgag tagtctgcag attggggatt tcctggtgaa agtgaacgat 420
cgccgtattc tggacggcat gtttgccatt tgtggcgtta gcgatagcaa attccgtacg 480
atctgtagca gtgtggacaa actggataaa gtctcttggg aagaggtcaa aaacgagatg 540
gttggtgaga aaggcctggc tcctgaagtg gctgaccgta ttggtgatta tgtccagcag 600
catggtggtg tttcactggt tgaacaactg ctgcaagacc cgaaactgtc tcagaacaaa 660
caggcactgg aaggtctggg tgatctgaaa ctgctgttcg agtatctgac gctgttcggt 720
attgacgaca aaatttcctt cgacctgtca ctggcacgtg gtctggatta ttatacaggc 780
gtaatctatg aggctgtact gctgcaaact ccagcacaag caggtgaaga acctctggga 840
gttggtagtg tagcggcagg gggtcgttat gatgggctgg tcgggatgtt cgatccaaaa 900
ggccgtaaag tcccgtgtgt tggtctgtct attggcgttg agcgtatctt ctccatcgtg 960
gagcaacgtc tggaagctct ggaagaaaaa atccgtacca ccgaaaccca agttctggtt 1020
gcctcagctc agaaaaaact gctggaagaa cgcctgaaac tggttagcga actgtgggat 1080
gctggcatta aagccgaact gctgtataaa aaaaacccga aactgctgaa tcagctgcag 1140
tattgtgagg aagcgggtat tcctctggtg gccattatcg gagaacagga actgaaagac 1200
ggcgttatta aactgcgtag cgtgacctct cgtgaagaag ttgacgttcg ccgtgaagat 1260
ctggtcgagg aaatcaaacg tcgtaccggt caacctctgt gtatttgcct cgag       1314

<210> 108
<211> 432
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 108
ggatccttcg acccaaaagg ccgtaaagtt ccgtgtgtag ggctgtctat cggtgttgag 60
cgtatcttct ccatcgttga gcagcgtctg gaagcactgg aggaaaaaat ccgtacgacc 120
gagactcaag tcctggttgc tagtgcccag aaaaaactgc tggaagagcg cctgaaactg 180
gttagtgagc tgtgggatgc cggtattaaa gccgaactgc tgtataaaaa aaacccgaaa 240
ctgctgaatc agctgcagta ttgtgaagaa gcgggcattc cgctggtagc gattatcggg 300
gaacaagaac tgaaagatgg cgtgatcaaa ctgcgtagcg ttacaagccg tgaggaagtg 360
gacgtccgcc gtgaggatct ggttgaagag attaaacgcc gtacaggtca gcctctgtgt 420
atttgcctcg ag                                                     432

<210> 109
<211> 143
<212> PRT
<213> Homo sapiens

<400> 109
Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp
 1               5                  10                  15      
Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala
            20                  25                  30          
Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val
        35                  40                  45              
Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val
    50                  55                  60                  
Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr
65                  70                  75                  80  
Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp
                85                  90                  95      
Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu
            100                 105                 110         
Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile
        115                 120                 125             
Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly
    130                 135                 140             


<210> 110
<211> 429
<212> DNA
<213> Homo sapiens

<400> 110
tgcctgaaga tcatgtgcga gatcctgagt tcacttcaga taggcgactt cctggtcaag 60
gtaaacgatc gacgcattct agatgggatg tttgctatct gtggtgtttc tgacagcaag 120
ttccgtacca tctgctcctc agtagacaag ctggacaagg tgtcctggga agaggtgaag 180
aatgagatgg tgggagagaa gggccttgca cctgaggtgg ctgaccgcat tggggactat 240
gtccagcaac atggtggggt atccctggtg gaacagctgc tccaggatcc taaactatcc 300
caaaacaagc aggccttgga gggcctggga gacctgaagt tgctctttga gtacctgacc 360
ctatttggca ttgatgacaa aatctccttt gacctgagcc ttgctcgagg gctggattac 420
tacactggg                                                         429

<210> 111
<211> 168
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      N-terminal 6xHis affinity tag

<400> 111
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Cys Leu Lys Ile Met Cys Glu Ile Leu
            20                  25                  30          
Ser Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg
        35                  40                  45              
Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe
    50                  55                  60                  
Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu
65                  70                  75                  80  
Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val
                85                  90                  95      
Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu
            100                 105                 110         
Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala
        115                 120                 125             
Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu
    130                 135                 140                 
Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly
145                 150                 155                 160 
Leu Asp Tyr Tyr Thr Gly Leu Glu
                165             


<210> 112
<211> 168
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histidyl tRNA Synthetase polypeptide with
      C-terminal 6xHis affinity tag

<400> 112
Met Gly Ser Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln
 1               5                  10                  15      
Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly
            20                  25                  30          
Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys
        35                  40                  45              
Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn
    50                  55                  60                  
Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile
65                  70                  75                  80  
Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu
                85                  90                  95      
Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu
            100                 105                 110         
Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp
        115                 120                 125             
Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr
    130                 135                 140                 
Thr Gly Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
145                 150                 155                 160 
Ser Thr His His His His His His
                165             


<210> 113
<211> 441
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized histidyl tRNA synthetase
      polynucleotide

<400> 113
ggatcctgcc tgaaaatcat gtgtgagatc ctgagtagtc tgcaaattgg cgactttctg 60
gtcaaagtga acgatcgccg tattctggat ggcatgttcg ccatctgtgg tgttagcgac 120
tccaaattcc gtacaatctg tagcagcgtg gacaaactgg ataaagtgtc ctgggaagag 180
gtgaaaaacg aaatggtggg tgaaaaaggt ctggctccgg aggttgctga ccgtatcggt 240
gattatgttc agcagcacgg cggtgttagt ctggttgaac aactgctgca agacccgaaa 300
ctgtctcaga acaaacaggc cctggaagga ctgggagatc tgaaactgct gttcgagtat 360
ctgacgctgt tcggcattga tgacaaaatt tctttcgacc tgtcactggc acgtggactg 420
gactattata ccggtctcga g                                           441
