
                                SEQUENCE LISTING

<110> aTyr Pharma Inc.
      Pangu Biopharma Limited
      Greene, Leslie Ann
      Chiang, Kyle P.
      Hong, Fei
      Vasserot, Alain P.
      Lo, Wing-Sze
      Watkins, Jeffry D.
      Quinn, Cheryl L.
      Mendlein, John D.
      

<120> INNOVATIVE DISCOVERY OF THERAPEUTIC,
  DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS
  OF GLYCYL-tRNA SYNTHETASES
  
  

<130> 120161.447PC

<140> PCT                 
<141> 2011-07-12  

<150> US 61/363,449       
<151> 2010-07-12  

<150> US 61/363,456       
<151> 2010-07-12  

<150> US 61/363,461       
<151> 2010-07-12  

<150> US 61/488,349       
<151> 2011-05-20  

<150> US 61/488,351       
<151> 2011-05-20  

<150> US 61/488,357       
<151> 2011-05-20  

<160> 183

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 77
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 1
aggaggtaaa acatatgcat catcatcatc atcacggtaa gcctatccct aaccctttgc 60
tcggtctcga ttctacg                                                77

<210> 2
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 2
taatgactcg ag                                                     12

<210> 3
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 3
aggagataaa acatatg                                                17

<210> 4
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 4
aggaggtaaa acat                                                   14

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 5
aggagataaa acat                                                   14

<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 6
gaaggagata tacat                                                  15

<210> 7
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 7
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgcaccacca tcatcaccat 60
taatgactcg ag                                                     72

<210> 8
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 8
catatgcatc atcatcatca tcacggtaag cctatcccta accctctcct cggtctcgat 60
tctacgggat cc                                                     72

<210> 9
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 9
ctcgagtaat ga                                                     12

<210> 10
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 10
catatgggat cc                                                     12

<210> 11
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 11
ctcgagggta agcctatccc taaccctctc ctcggtctcg attctacgca ccaccaccac 60
caccactaat ga                                                     72

<210> 12
<211> 396
<212> PRT
<213> Homo sapiens

<400> 12
Met Asp Gly Ala Gly Ala Glu Glu Val Leu Ala Pro Leu Arg Leu Ala
 1               5                  10                  15      
Val Arg Gln Gln Gly Asp Leu Val Arg Lys Leu Lys Glu Asp Lys Ala
            20                  25                  30          
Pro Gln Val Asp Val Asp Lys Ala Val Ala Glu Leu Lys Ala Arg Lys
        35                  40                  45              
Arg Val Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys Asp Asp Ile
    50                  55                  60                  
Val Asp Arg Ala Lys Met Glu Asp Thr Leu Lys Arg Arg Phe Phe Tyr
65                  70                  75                  80  
Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr Asp Phe
                85                  90                  95      
Gly Pro Val Gly Cys Ala Leu Lys Asn Asn Ile Ile Gln Thr Trp Arg
            100                 105                 110         
Gln His Phe Ile Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys Thr Met
        115                 120                 125             
Leu Thr Pro Glu Pro Val Leu Lys Thr Ser Gly His Val Asp Lys Phe
    130                 135                 140                 
Ala Asp Phe Met Val Lys Asp Val Lys Asn Gly Glu Cys Phe Arg Ala
145                 150                 155                 160 
Asp His Leu Leu Lys Ala His Leu Gln Lys Leu Met Ser Asp Lys Lys
                165                 170                 175     
Cys Ser Val Glu Lys Lys Ser Glu Met Glu Ser Val Leu Ala Gln Leu
            180                 185                 190         
Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr Asn
        195                 200                 205             
Val Lys Ser Pro Ile Thr Gly Asn Asp Leu Ser Pro Pro Val Ser Phe
    210                 215                 220                 
Asn Leu Met Phe Lys Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly
225                 230                 235                 240 
Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg
                245                 250                 255     
Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile
            260                 265                 270         
Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg
        275                 280                 285             
Val Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp Pro Ser
    290                 295                 300                 
Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr
305                 310                 315                 320 
Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met
                325                 330                 335     
Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu
            340                 345                 350         
Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile
        355                 360                 365             
Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu Met Ala
    370                 375                 380                 
His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys
385                 390                 395     


<210> 13
<211> 1188
<212> DNA
<213> Homo sapiens

<400> 13
atggacggcg cgggggctga ggaggtgctg gcacctctga ggctagcagt gcgccagcag 60
ggagatcttg tgcgaaaact caaagaagat aaagcacccc aagtagacgt agacaaagca 120
gtggctgagc tcaaagcccg caagagggtt ctggaagcaa aggagctggc gttacagccc 180
aaagatgata ttgtagaccg agcaaaaatg gaagataccc tgaagaggag gtttttctat 240
gatcaagctt ttgctattta tggaggtgtt agtggtctgt atgactttgg gccagttggc 300
tgtgctttga agaacaatat tattcagacc tggaggcagc actttatcca agaggaacag 360
atcctggaga tcgattgcac catgctcacc cctgagccag ttttaaagac ctctggccat 420
gtagacaaat ttgctgactt catggtgaaa gacgtaaaaa atggagaatg ttttcgtgct 480
gaccatctat taaaagctca tttacagaaa ttgatgtctg ataagaagtg ttctgtcgaa 540
aagaaatcag aaatggaaag tgttttggcc cagcttgata actatggaca gcaagaactt 600
gcggatcttt ttgtgaacta taatgtaaaa tctcccatta ctggaaatga tctatcccct 660
ccagtgtctt ttaacttaat gttcaagact ttcattgggc ctggaggaaa catgcctggg 720
tacttgagac cagaaactgc acaggggatt ttcttgaatt tcaaacgact tttggagttc 780
aaccaaggaa agttgccttt tgctgctgcc cagattggaa attcttttag aaatgagatc 840
tcccctcgat ctggactgat cagagtcaga gaattcacaa tggcagaaat tgagcacttt 900
gtagatccca gtgagaaaga ccaccccaag ttccagaatg tggcagacct tcacctttat 960
ttgtattcag caaaagccca ggtcagcgga cagtccgctc ggaaaatgcg cctgggagat 1020
gctgttgaac agggtgtgat taataacaca gtattaggct atttcattgg ccgcatctac 1080
ctctacctca cgaaggttgg aatatctcca gataaactcc gcttccggca gcacatggag 1140
aatgagatgg cccattatgc ctgtgactgt tgggatgcag aatccaaa              1188

<210> 14
<211> 20
<212> PRT
<213> Mus musculus

<400> 14
Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly
 1               5                  10                  15      
Cys Ala Leu Lys
            20  


<210> 15
<211> 160
<212> PRT
<213> Mus musculus

<400> 15
Asn Asn Ile Ile Gln Ala Trp Arg Gln His Phe Ile Gln Glu Glu Gln
 1               5                  10                  15      
Ile Leu Glu Ile Asp Cys Thr Met Leu Thr Pro Glu Pro Val Leu Lys
            20                  25                  30          
Thr Ser Gly His Val Asp Lys Phe Ala Asp Phe Met Val Lys Asp Val
        35                  40                  45              
Lys Asn Gly Glu Cys Phe Arg Ala Asp His Leu Leu Lys Ala His Leu
    50                  55                  60                  
Gln Lys Leu Met Ser Asp Lys Lys Cys Ser Ala Glu Lys Lys Ser Glu
65                  70                  75                  80  
Met Glu Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu
                85                  90                  95      
Ala Asp Leu Phe Val Asn Tyr Asn Val Lys Ser Pro Thr Thr Gly Asn
            100                 105                 110         
Asp Leu Ser Pro Pro Val Pro Phe Asn Leu Met Phe Gln Thr Phe Ile
        115                 120                 125             
Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln
    130                 135                 140                 
Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys
145                 150                 155                 160 


<210> 16
<211> 12
<212> PRT
<213> Mus musculus

<400> 16
Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg
 1               5                  10          


<210> 17
<211> 60
<212> PRT
<213> Mus musculus

<400> 17
Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr
 1               5                  10                  15      
Met Ala Glu Ile Glu His Phe Val Asp Pro Thr Glu Lys Asp His Pro
            20                  25                  30          
Lys Phe Gln Ser Val Ala Asp Leu Cys Leu Tyr Leu Tyr Ser Ala Lys
        35                  40                  45              
Ala Gln Val Thr Gly Gln Ser Ala Arg Lys Met Arg
    50                  55                  60  


<210> 18
<211> 21
<212> PRT
<213> Mus musculus

<400> 18
Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Ser Val Leu Gly
 1               5                  10                  15      
Tyr Phe Ile Gly Arg
            20      


<210> 19
<211> 274
<212> PRT
<213> Mus musculus

<400> 19
Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly
 1               5                  10                  15      
Cys Ala Leu Lys Asn Asn Ile Ile Gln Ala Trp Arg Gln His Phe Ile
            20                  25                  30          
Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys Thr Met Leu Thr Pro Glu
        35                  40                  45              
Pro Val Leu Lys Thr Ser Gly His Val Asp Lys Phe Ala Asp Phe Met
    50                  55                  60                  
Val Lys Asp Val Lys Asn Gly Glu Cys Phe Arg Ala Asp His Leu Leu
65                  70                  75                  80  
Lys Ala His Leu Gln Lys Leu Met Ser Asp Lys Lys Cys Ser Ala Glu
                85                  90                  95      
Lys Lys Ser Glu Met Glu Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly
            100                 105                 110         
Gln Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr Asn Val Lys Ser Pro
        115                 120                 125             
Thr Thr Gly Asn Asp Leu Ser Pro Pro Val Pro Phe Asn Leu Met Phe
    130                 135                 140                 
Gln Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro
145                 150                 155                 160 
Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe
                165                 170                 175     
Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe
            180                 185                 190         
Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe
        195                 200                 205             
Thr Met Ala Glu Ile Glu His Phe Val Asp Pro Thr Glu Lys Asp His
    210                 215                 220                 
Pro Lys Phe Gln Ser Val Ala Asp Leu Cys Leu Tyr Leu Tyr Ser Ala
225                 230                 235                 240 
Lys Ala Gln Val Thr Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp
                245                 250                 255     
Ala Val Glu Gln Gly Val Ile Asn Asn Ser Val Leu Gly Tyr Phe Ile
            260                 265                 270         
Gly Arg
        


<210> 20
<211> 546
<212> PRT
<213> Homo sapiens

<400> 20
Met Pro Ser Pro Arg Pro Val Leu Leu Arg Gly Ala Arg Ala Ala Leu
 1               5                  10                  15      
Leu Leu Leu Leu Pro Pro Arg Leu Leu Ala Arg Pro Ser Leu Leu Leu
            20                  25                  30          
Arg Arg Ser Leu Ser Ala Ala Ser Cys Pro Pro Ile Ser Leu Pro Ala
        35                  40                  45              
Ala Ala Ser Arg Ser Ser Met Asp Gly Ala Gly Ala Glu Glu Val Leu
    50                  55                  60                  
Ala Pro Leu Arg Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys
65                  70                  75                  80  
Leu Lys Glu Asp Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala
                85                  90                  95      
Glu Leu Lys Ala Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu
            100                 105                 110         
Gln Pro Lys Asp Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu
        115                 120                 125             
Lys Arg Arg Phe Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val
    130                 135                 140                 
Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn
145                 150                 155                 160 
Ile Ile Gln Thr Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu
                165                 170                 175     
Glu Ile Asp Cys Thr Met Leu Thr Pro Glu Pro Val Leu Lys Thr Ser
            180                 185                 190         
Gly His Val Asp Lys Phe Ala Asp Phe Met Val Lys Asp Val Lys Asn
        195                 200                 205             
Gly Glu Cys Phe Arg Ala Asp His Leu Leu Lys Ala His Leu Gln Lys
    210                 215                 220                 
Leu Met Ser Asp Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu
225                 230                 235                 240 
Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp
                245                 250                 255     
Leu Phe Val Asn Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu
            260                 265                 270         
Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro
        275                 280                 285             
Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile
    290                 295                 300                 
Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro
305                 310                 315                 320 
Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro
                325                 330                 335     
Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu
            340                 345                 350         
His Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val
        355                 360                 365             
Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly
    370                 375                 380                 
Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val
385                 390                 395                 400 
Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr
                405                 410                 415     
Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His
            420                 425                 430         
Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu
        435                 440                 445             
Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg
    450                 455                 460                 
Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu
465                 470                 475                 480 
Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln
                485                 490                 495     
Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala
            500                 505                 510         
Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr
        515                 520                 525             
Glu Met Glu Met Leu Leu Asn Glu Lys Gly Gly Arg Ser Cys Ser Glu
    530                 535                 540                 
Cys Asn
545     


<210> 21
<211> 1641
<212> DNA
<213> Homo sapiens

<400> 21
atgccctctc cgcgtccagt gctgcttaga ggtgctcgcg ccgctctgct gctgctgctg 60
ccgccccggc tcttagcccg accctcgctc ctgctccgcc ggtccctcag cgcggcctcc 120
tgccccccga tctccttgcc cgccgccgcc tcccggagca gcatggacgg cgcgggggct 180
gaggaggtgc tggcacctct gaggctagca gtgcgccagc agggagatct tgtgcgaaaa 240
ctcaaagaag ataaagcacc ccaagtagac gtagacaaag cagtggctga gctcaaagcc 300
cgcaagaggg ttctggaagc aaaggagctg gcgttacagc ccaaagatga tattgtagac 360
cgagcaaaaa tggaagatac cctgaagagg aggtttttct atgatcaagc ttttgctatt 420
tatggaggtg ttagtggtct gtatgacttt gggccagttg gctgtgcttt gaagaacaat 480
attattcaga cctggaggca gcactttatc caagaggaac agatcctgga gatcgattgc 540
accatgctca cccctgagcc agttttaaag acctctggcc atgtagacaa atttgctgac 600
ttcatggtga aagacgtaaa aaatggagaa tgttttcgtg ctgaccatct attaaaagct 660
catttacaga aattgatgtc tgataagaag tgttctgtcg aaaagaaatc agaaatggaa 720
agtgttttgg cccagcttga taactatgga cagcaagaac ttgcggatct ttttgtgaac 780
tataatgtaa aatctcccat tactggaaat gatctatccc ctccagtgtc ttttaactta 840
atgttcaaga ctttcattgg gcctggagga aacatgcctg ggtacttgag accagaaact 900
gcacagggga ttttcttgaa tttcaaacga cttttggagt tcaaccaagg aaagttgcct 960
tttgctgctg cccagattgg aaattctttt agaaatgaga tctcccctcg atctggactg 1020
atcagagtca gagaattcac aatggcagaa attgagcact ttgtagatcc cagtgagaaa 1080
gaccacccca agttccagaa tgtggcagac cttcaccttt atttgtattc agcaaaagcc 1140
caggtcagcg gacagtccgc tcggaaaatg cgcctgggag atgctgttga acagggtgtg 1200
attaataaca cagtattagg ctatttcatt ggccgcatct acctctacct cacgaaggtt 1260
ggaatatctc cagataaact ccgcttccgg cagcacatgg agaatgagat ggcccattat 1320
gcctgtgact gttgggatgc agaatccaaa acatcctacg gttggattga gattgttgga 1380
tgtgctgatc gttcctgtta tgacctctcc tgtcatgcac gagccaccaa agtcccactt 1440
gtagctgaga aacctctgaa agaacccaaa acagtcaatg ttgttcagtt tgaacccagt 1500
aagggagcaa ttggtaaggc atataagaag gatgcaaaac tggtgatgga gtatcttgcc 1560
atttgtgatg agtgctacat tacagaaatg gagatgctgc tgaatgagaa aggtggaaga 1620
agttgttccg aatgtaattg a                                           1641

<210> 22
<211> 606
<212> PRT
<213> Homo sapiens

<400> 22
Met Pro Ser Pro Arg Pro Val Leu Leu Arg Gly Ala Arg Ala Ala Leu
 1               5                  10                  15      
Leu Leu Leu Leu Pro Pro Arg Leu Leu Ala Arg Pro Ser Leu Leu Leu
            20                  25                  30          
Arg Arg Ser Leu Ser Ala Ala Ser Cys Pro Pro Ile Ser Leu Pro Ala
        35                  40                  45              
Ala Ala Ser Arg Ser Ser Met Asp Gly Ala Gly Ala Glu Glu Val Leu
    50                  55                  60                  
Ala Pro Leu Arg Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys
65                  70                  75                  80  
Leu Lys Glu Asp Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala
                85                  90                  95      
Glu Leu Lys Ala Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu
            100                 105                 110         
Gln Pro Lys Asp Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu
        115                 120                 125             
Lys Arg Arg Phe Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val
    130                 135                 140                 
Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn
145                 150                 155                 160 
Ile Ile Gln Thr Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu
                165                 170                 175     
Glu Ile Asp Cys Thr Met Leu Thr Pro Glu Pro Val Leu Lys Thr Ser
            180                 185                 190         
Gly His Val Asp Lys Phe Ala Asp Phe Met Val Lys Asp Val Lys Asn
        195                 200                 205             
Gly Glu Cys Phe Arg Ala Asp His Leu Leu Lys Ala His Leu Gln Lys
    210                 215                 220                 
Leu Met Ser Asp Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu
225                 230                 235                 240 
Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp
                245                 250                 255     
Leu Phe Val Asn Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu
            260                 265                 270         
Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro
        275                 280                 285             
Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile
    290                 295                 300                 
Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro
305                 310                 315                 320 
Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro
                325                 330                 335     
Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu
            340                 345                 350         
His Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val
        355                 360                 365             
Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly
    370                 375                 380                 
Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val
385                 390                 395                 400 
Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr
                405                 410                 415     
Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His
            420                 425                 430         
Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu
        435                 440                 445             
Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg
    450                 455                 460                 
Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu
465                 470                 475                 480 
Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln
                485                 490                 495     
Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala
            500                 505                 510         
Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr
        515                 520                 525             
Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr
    530                 535                 540                 
Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg
545                 550                 555                 560 
Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu
                565                 570                 575     
Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr
            580                 585                 590         
Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Arg Lys Pro
        595                 600                 605     


<210> 23
<211> 1821
<212> DNA
<213> Homo sapiens

<400> 23
atgccctctc cgcgtccagt gctgcttaga ggtgctcgcg ccgctctgct gctgctgctg 60
ccgccccggc tcttagcccg accctcgctc ctgctccgcc ggtccctcag cgcggcctcc 120
tgccccccga tctccttgcc cgccgccgcc tcccggagca gcatggacgg cgcgggggct 180
gaggaggtgc tggcacctct gaggctagca gtgcgccagc agggagatct tgtgcgaaaa 240
ctcaaagaag ataaagcacc ccaagtagac gtagacaaag cagtggctga gctcaaagcc 300
cgcaagaggg ttctggaagc aaaggagctg gcgttacagc ccaaagatga tattgtagac 360
cgagcaaaaa tggaagatac cctgaagagg aggtttttct atgatcaagc ttttgctatt 420
tatggaggtg ttagtggtct gtatgacttt gggccagttg gctgtgcttt gaagaacaat 480
attattcaga cctggaggca gcactttatc caagaggaac agatcctgga gatcgattgc 540
accatgctca cccctgagcc agttttaaag acctctggcc atgtagacaa atttgctgac 600
ttcatggtga aagacgtaaa aaatggagaa tgttttcgtg ctgaccatct attaaaagct 660
catttacaga aattgatgtc tgataagaag tgttctgtcg aaaagaaatc agaaatggaa 720
agtgttttgg cccagcttga taactatgga cagcaagaac ttgcggatct ttttgtgaac 780
tataatgtaa aatctcccat tactggaaat gatctatccc ctccagtgtc ttttaactta 840
atgttcaaga ctttcattgg gcctggagga aacatgcctg ggtacttgag accagaaact 900
gcacagggga ttttcttgaa tttcaaacga cttttggagt tcaaccaagg aaagttgcct 960
tttgctgctg cccagattgg aaattctttt agaaatgaga tctcccctcg atctggactg 1020
atcagagtca gagaattcac aatggcagaa attgagcact ttgtagatcc cagtgagaaa 1080
gaccacccca agttccagaa tgtggcagac cttcaccttt atttgtattc agcaaaagcc 1140
caggtcagcg gacagtccgc tcggaaaatg cgcctgggag atgctgttga acagggtgtg 1200
attaataaca cagtattagg ctatttcatt ggccgcatct acctctacct cacgaaggtt 1260
ggaatatctc cagataaact ccgcttccgg cagcacatgg agaatgagat ggcccattat 1320
gcctgtgact gttgggatgc agaatccaaa acatcctacg gttggattga gattgttgga 1380
tgtgctgatc gttcctgtta tgacctctcc tgtcatgcac gagccaccaa agtcccactt 1440
gtagctgaga aacctctgaa agaacccaaa acagtcaatg ttgttcagtt tgaacccagt 1500
aagggagcaa ttggtaaggc atataagaag gatgcaaaac tggtgatgga gtatcttgcc 1560
atttgtgatg agtgctacat tacagaaatg gagatgctgc tgaatgagaa aggggaattc 1620
acaattgaaa ctgaagggaa aacatttcag ttaacaaaag acatgatcaa tgtgaagaga 1680
ttccagaaaa cactatatgt ggaagaagtt gttccgaatg taattgaacc ttccttcggc 1740
ctgggtagga tcatgtatac ggtatttgaa catacattcc atgtacgaga aggagatgaa 1800
cagagaacac ggaagccctg a                                           1821

<210> 24
<211> 197
<212> PRT
<213> Homo sapiens

<400> 24
Met Pro Ser Pro Arg Pro Val Leu Leu Arg Gly Ala Arg Ala Ala Leu
 1               5                  10                  15      
Leu Leu Leu Leu Pro Pro Arg Leu Leu Ala Arg Pro Ser Leu Leu Leu
            20                  25                  30          
Arg Arg Ser Leu Ser Ala Ala Ser Cys Pro Pro Ile Ser Leu Pro Ala
        35                  40                  45              
Ala Ala Ser Arg Ser Ser Met Asp Gly Ala Gly Ala Glu Glu Val Leu
    50                  55                  60                  
Ala Pro Leu Arg Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys
65                  70                  75                  80  
Leu Lys Glu Asp Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala
                85                  90                  95      
Glu Leu Lys Ala Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu
            100                 105                 110         
Gln Pro Lys Asp Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu
        115                 120                 125             
Lys Arg Arg Phe Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val
    130                 135                 140                 
Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn
145                 150                 155                 160 
Ile Ile Gln Thr Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu
                165                 170                 175     
Glu Ile Asp Cys Thr Met Leu Thr Pro Glu Pro Val Leu Asn Ser Phe
            180                 185                 190         
Thr Glu Ile Asp Val
        195         


<210> 25
<211> 594
<212> DNA
<213> Homo sapiens

<400> 25
atgccctctc cgcgtccagt gctgcttaga ggtgctcgcg ccgctctgct gctgctgctg 60
ccgccccggc tcttagcccg accctcgctc ctgctccgcc ggtccctcag cgcggcctcc 120
tgccccccga tctccttgcc cgccgccgcc tcccggagca gcatggacgg cgcgggggct 180
gaggaggtgc tggcacctct gaggctagca gtgcgccagc agggagatct tgtgcgaaaa 240
ctcaaagaag ataaagcacc ccaagtagac gtagacaaag cagtggctga gctcaaagcc 300
cgcaagaggg ttctggaagc aaaggagctg gcgttacagc ccaaagatga tattgtagac 360
cgagcaaaaa tggaagatac cctgaagagg aggtttttct atgatcaagc ttttgctatt 420
tatggaggtg ttagtggtct gtatgacttt gggccagttg gctgtgcttt gaagaacaat 480
attattcaga cctggaggca gcactttatc caagaggaac agatcctgga gatcgattgc 540
accatgctca cccctgagcc agttttaaac tcatttacag aaattgatgt ctga       594

<210> 26
<211> 50
<212> DNA
<213> Homo sapiens

<400> 26
tggagatgct gctgaatgag aaaggtggaa gaagttgttc cgaatgtaat            50

<210> 27
<211> 16
<212> PRT
<213> Homo sapiens

<400> 27
Glu Met Leu Leu Asn Glu Lys Gly Gly Arg Ser Cys Ser Glu Cys Asn
 1               5                  10                  15      


<210> 28
<211> 50
<212> DNA
<213> Homo sapiens

<400> 28
acgagaagga gatgaacaga gaacacggaa gccctgacca ggcatggagt            50

<210> 29
<211> 11
<212> PRT
<213> Homo sapiens

<400> 29
Arg Glu Gly Asp Glu Gln Arg Thr Arg Lys Pro
 1               5                  10      


<210> 30
<211> 50
<212> DNA
<213> Homo sapiens

<400> 30
tgctcacccc tgagccagtt ttaaactcat ttacagaaat tgatgtctga            50

<210> 31
<211> 15
<212> PRT
<213> Homo sapiens

<400> 31
Leu Thr Pro Glu Pro Val Leu Asn Ser Phe Thr Glu Ile Asp Val
 1               5                  10                  15  


<210> 32
<211> 213
<212> PRT
<213> Homo sapiens

<400> 32
Met Asp Gly Ala Gly Ala Glu Glu Val Leu Ala Pro Leu Arg Leu Ala
 1               5                  10                  15      
Val Arg Gln Gln Gly Asp Leu Val Arg Lys Leu Lys Glu Asp Lys Ala
            20                  25                  30          
Pro Gln Val Asp Val Asp Lys Ala Val Ala Glu Leu Lys Ala Arg Lys
        35                  40                  45              
Arg Val Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys Asp Asp Ile
    50                  55                  60                  
Val Asp Arg Ala Lys Met Glu Asp Thr Leu Lys Arg Arg Phe Phe Tyr
65                  70                  75                  80  
Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr Asp Phe
                85                  90                  95      
Gly Pro Val Gly Cys Ala Leu Lys Asn Asn Ile Ile Gln Thr Trp Arg
            100                 105                 110         
Gln His Phe Ile Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys Thr Met
        115                 120                 125             
Leu Thr Pro Glu Pro Val Leu Lys Thr Ser Gly His Val Asp Lys Phe
    130                 135                 140                 
Ala Asp Phe Met Val Lys Asp Val Lys Asn Gly Glu Cys Phe Arg Ala
145                 150                 155                 160 
Asp His Leu Leu Lys Ala His Leu Gln Lys Leu Met Ser Asp Lys Lys
                165                 170                 175     
Cys Ser Val Glu Lys Lys Ser Glu Met Glu Ser Val Leu Ala Gln Leu
            180                 185                 190         
Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr Asn
        195                 200                 205             
Val Lys Ser Pro Ile
    210             


<210> 33
<211> 639
<212> DNA
<213> Homo sapiens

<400> 33
atggacggcg cgggggctga ggaggtgctg gcacctctga ggctagcagt gcgccagcag 60
ggagatcttg tgcgaaaact caaagaagat aaagcacccc aagtagacgt agacaaagca 120
gtggctgagc tcaaagcccg caagagggtt ctggaagcaa aggagctggc gttacagccc 180
aaagatgata ttgtagaccg agcaaaaatg gaagataccc tgaagaggag gtttttctat 240
gatcaagctt ttgctattta tggaggtgtt agtggtctgt atgactttgg gccagttggc 300
tgtgctttga agaacaatat tattcagacc tggaggcagc actttatcca agaggaacag 360
atcctggaga tcgattgcac catgctcacc cctgagccag ttttaaagac ctctggccat 420
gtagacaaat ttgctgactt catggtgaaa gacgtaaaaa atggagaatg ttttcgtgct 480
gaccatctat taaaagctca tttacagaaa ttgatgtctg ataagaagtg ttctgtcgaa 540
aagaaatcag aaatggaaag tgttttggcc cagcttgata actatggaca gcaagaactt 600
gcggatcttt ttgtgaacta taatgtaaaa tctcccatt                        639

<210> 34
<211> 61
<212> PRT
<213> Homo sapiens

<400> 34
Met Asp Gly Ala Gly Ala Glu Glu Val Leu Ala Pro Leu Arg Leu Ala
 1               5                  10                  15      
Val Arg Gln Gln Gly Asp Leu Val Arg Lys Leu Lys Glu Asp Lys Ala
            20                  25                  30          
Pro Gln Val Asp Val Asp Lys Ala Val Ala Glu Leu Lys Ala Arg Lys
        35                  40                  45              
Arg Val Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys
    50                  55                  60      


<210> 35
<211> 183
<212> DNA
<213> Homo sapiens

<400> 35
atggacggcg cgggggctga ggaggtgctg gcacctctga ggctagcagt gcgccagcag 60
ggagatcttg tgcgaaaact caaagaagat aaagcacccc aagtagacgt agacaaagca 120
gtggctgagc tcaaagcccg caagagggtt ctggaagcaa aggagctggc gttacagccc 180
aaa                                                               183

<210> 36
<211> 420
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis affinity tag

<400> 36
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Asp Gly Ala Gly Ala Glu Glu Val Leu
            20                  25                  30          
Ala Pro Leu Arg Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys
        35                  40                  45              
Leu Lys Glu Asp Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala
    50                  55                  60                  
Glu Leu Lys Ala Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu
65                  70                  75                  80  
Gln Pro Lys Asp Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu
                85                  90                  95      
Lys Arg Arg Phe Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val
            100                 105                 110         
Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn
        115                 120                 125             
Ile Ile Gln Thr Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu
    130                 135                 140                 
Glu Ile Asp Cys Thr Met Leu Thr Pro Glu Pro Val Leu Lys Thr Ser
145                 150                 155                 160 
Gly His Val Asp Lys Phe Ala Asp Phe Met Val Lys Asp Val Lys Asn
                165                 170                 175     
Gly Glu Cys Phe Arg Ala Asp His Leu Leu Lys Ala His Leu Gln Lys
            180                 185                 190         
Leu Met Ser Asp Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu
        195                 200                 205             
Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp
    210                 215                 220                 
Leu Phe Val Asn Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu
225                 230                 235                 240 
Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro
                245                 250                 255     
Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile
            260                 265                 270         
Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro
        275                 280                 285             
Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro
    290                 295                 300                 
Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu
305                 310                 315                 320 
His Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val
                325                 330                 335     
Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly
            340                 345                 350         
Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val
        355                 360                 365             
Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr
    370                 375                 380                 
Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His
385                 390                 395                 400 
Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu
                405                 410                 415     
Ser Lys Leu Glu
            420 


<210> 37
<211> 420
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis affinity tag

<400> 37
Met Gly Ser Asp Gly Ala Gly Ala Glu Glu Val Leu Ala Pro Leu Arg
 1               5                  10                  15      
Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys Leu Lys Glu Asp
            20                  25                  30          
Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala Glu Leu Lys Ala
        35                  40                  45              
Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys Asp
    50                  55                  60                  
Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu Lys Arg Arg Phe
65                  70                  75                  80  
Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr
                85                  90                  95      
Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn Ile Ile Gln Thr
            100                 105                 110         
Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys
        115                 120                 125             
Thr Met Leu Thr Pro Glu Pro Val Leu Lys Thr Ser Gly His Val Asp
    130                 135                 140                 
Lys Phe Ala Asp Phe Met Val Lys Asp Val Lys Asn Gly Glu Cys Phe
145                 150                 155                 160 
Arg Ala Asp His Leu Leu Lys Ala His Leu Gln Lys Leu Met Ser Asp
                165                 170                 175     
Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu Ser Val Leu Ala
            180                 185                 190         
Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu Phe Val Asn
        195                 200                 205             
Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu Ser Pro Pro Val
    210                 215                 220                 
Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro Gly Gly Asn Met
225                 230                 235                 240 
Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe
                245                 250                 255     
Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala
            260                 265                 270         
Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu
        275                 280                 285             
Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp
    290                 295                 300                 
Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His
305                 310                 315                 320 
Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg
                325                 330                 335     
Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr
            340                 345                 350         
Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val
        355                 360                 365             
Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu
    370                 375                 380                 
Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Leu Glu
385                 390                 395                 400 
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His
                405                 410                 415     
His His His His
            420 


<210> 38
<211> 1197
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized glycyl tRNA Synthetase
      polynucleotide

<400> 38
ggatccgatg gtgccggagc tgaagaagtc ctggcccctc tgcgtctggc tgttcgtcaa 60
caaggtgatc tggtccgtaa actgaaagag gacaaagcac ctcaggttga tgtcgataaa 120
gcggtggcgg aactgaaagc ccgtaaacgt gttctggaag cgaaagagct ggccctgcaa 180
ccaaaagatg atatcgtgga ccgtgctaaa atggaggata ccctgaaacg tcgttttttc 240
tatgatcagg cgttcgccat ctatggtggt gttagcggtc tgtatgattt cggcccggtg 300
ggttgtgctc tgaaaaacaa catcatccaa acgtggcgtc agcatttcat ccaagaggag 360
caaatcctgg agattgactg taccatgctg acacctgagc cagtgctgaa aacctctggt 420
catgtggaca aattcgccga ctttatggtg aaagacgtga aaaatgggga gtgttttcgt 480
gccgaccatc tgctgaaagc acatctgcaa aaactgatga gcgataaaaa atgttccgtg 540
gaaaaaaaat ccgagatgga gagcgtactg gcccaactgg ataattatgg gcagcaagag 600
ctggcggacc tgtttgtgaa ctataacgtg aaaagcccga ttaccggcaa tgatctgtct 660
cctccggtga gcttcaatct gatgttcaaa acgttcatcg gtccgggtgg taatatgccg 720
ggttatctgc gcccagaaac agcacagggc atctttctga acttcaaacg tctgctggag 780
tttaatcagg gcaaactgcc gttcgctgct gctcaaatcg gcaacagctt tcgtaacgag 840
attagccctc gtagtgggct gatccgtgtc cgtgaattca ctatggctga gatcgaacac 900
tttgtggacc cgagcgaaaa agaccatcca aaattccaaa atgtggccga cctgcatctg 960
tatctgtata gtgccaaagc ccaggttagt ggtcagtctg ctcgtaaaat gcgcctgggt 1020
gatgccgtag aacagggcgt tatcaacaat accgtgctgg ggtatttcat tggccgtatc 1080
tatctgtatc tgacaaaagt gggcatttcg ccggataaac tgcgtttccg tcaacacatg 1140
gagaatgaga tggcccatta tgcctgtgat tgctgggatg ccgaatccaa actcgag    1197

<210> 39
<211> 437
<212> PRT
<213> Homo sapiens

<400> 39
Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys
 1               5                  10                  15      
Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile
            20                  25                  30          
Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu
        35                  40                  45              
Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln
    50                  55                  60                  
Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val
65                  70                  75                  80  
Ser Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln
                85                  90                  95      
Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr
            100                 105                 110         
Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg
        115                 120                 125             
Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp
    130                 135                 140                 
Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala
145                 150                 155                 160 
Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val
                165                 170                 175     
Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val
            180                 185                 190         
Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys
        195                 200                 205             
Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr
    210                 215                 220                 
Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile
225                 230                 235                 240 
Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val
                245                 250                 255     
Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn Val
            260                 265                 270         
Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu
        275                 280                 285             
His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser
    290                 295                 300                 
Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser
305                 310                 315                 320 
Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu
                325                 330                 335     
Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile
            340                 345                 350         
Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val
        355                 360                 365             
Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu
    370                 375                 380                 
Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu
385                 390                 395                 400 
Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp
                405                 410                 415     
Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys
            420                 425                 430         
Glu Thr Ile Glu Glu
        435         


<210> 40
<211> 1314
<212> DNA
<213> Homo sapiens

<400> 40
gggattttct tgaatttcaa acgacttttg gagttcaacc aaggaaagtt gccttttgct 60
gctgcccaga ttggaaattc ttttagaaat gagatctccc ctcgatctgg actgatcaga 120
gtcagagaat tcacaatggc agaaattgag cactttgtag atcccagtga gaaagaccac 180
cccaagttcc agaatgtggc agaccttcac ctttatttgt attcagcaaa agcccaggtc 240
agcggacagt ccgctcggaa aatgcgcctg ggagatgctg ttgaacaggg tgtgattaat 300
aacacagtat taggctattt cattggccgc atctacctct acctcacgaa ggttggaata 360
tctccagata aactccgctt ccggcagcac atggagaatg agatggccca ttatgcctgt 420
gactgttggg atgcagaatc caaaacatcc tacggttgga ttgagattgt tggatgtgct 480
gatcgttcct gttatgacct ctcctgtcat gcacgagcca ccaaagtccc acttgtagct 540
gagaaacctc tgaaagaacc caaaacagtc aatgttgttc agtttgaacc cagtaaggga 600
gcaattggta aggcatataa gaaggatgca aaactggtga tggagtatct tgccatttgt 660
gatgagtgct acattacaga aatggagatg ctgctgaatg agaaagggga attcacaatt 720
gaaactgaag ggaaaacatt tcagttaaca aaagacatga tcaatgtgaa gagattccag 780
aaaacactat atgtggaaga agttgttccg aatgtaattg aaccttcctt cggcctgggt 840
aggatcatgt atacggtatt tgaacataca ttccatgtac gagaaggaga tgaacagaga 900
acattcttca gtttccctgc tgtagttgct ccattcaaat gttccgtcct cccactgagc 960
caaaaccagg agttcatgcc atttgtcaag gaattatcgg aagccctgac caggcatgga 1020
gtatctcaca aagtagacga ttcctctggg tcaatcggaa ggcgctatgc caggactgat 1080
gagattggcg tggcttttgg tgtcaccatt gactttgaca cagtgaacaa gaccccccac 1140
actgcaactc tgagggaccg tgactcaatg cggcagataa gagcagagat ctctgagctg 1200
cccagcatag tccaagacct agccaatggc aacatcacat gggctgatgt ggaggccagg 1260
tatcctctgt ttgaagggca agagactggt aaaaaagaga caatcgagga atga       1314

<210> 41
<211> 230
<212> PRT
<213> Homo sapiens

<400> 41
Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys
 1               5                  10                  15      
Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr
            20                  25                  30          
Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn
        35                  40                  45              
Val Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn
    50                  55                  60                  
Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe
65                  70                  75                  80  
Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe
                85                  90                  95      
Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu
            100                 105                 110         
Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala
        115                 120                 125             
Leu Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser
    130                 135                 140                 
Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly
145                 150                 155                 160 
Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr
                165                 170                 175     
Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu
            180                 185                 190         
Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala
        195                 200                 205             
Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys
    210                 215                 220                 
Lys Glu Thr Ile Glu Glu
225                 230 


<210> 42
<211> 693
<212> DNA
<213> Homo sapiens

<400> 42
aaggatgcaa aactggtgat ggagtatctt gccatttgtg atgagtgcta cattacagaa 60
atggagatgc tgctgaatga gaaaggggaa ttcacaattg aaactgaagg gaaaacattt 120
cagttaacaa aagacatgat caatgtgaag agattccaga aaacactata tgtggaagaa 180
gttgttccga atgtaattga accttccttc ggcctgggta ggatcatgta tacggtattt 240
gaacatacat tccatgtacg agaaggagat gaacagagaa cattcttcag tttccctgct 300
gtagttgctc cattcaaatg ttccgtcctc ccactgagcc aaaaccagga gttcatgcca 360
tttgtcaagg aattatcgga agccctgacc aggcatggag tatctcacaa agtagacgat 420
tcctctgggt caatcggaag gcgctatgcc aggactgatg agattggcgt ggcttttggt 480
gtcaccattg actttgacac agtgaacaag accccccaca ctgcaactct gagggaccgt 540
gactcaatgc ggcagataag agcagagatc tctgagctgc ccagcatagt ccaagaccta 600
gccaatggca acatcacatg ggctgatgtg gaggccaggt atcctctgtt tgaagggcaa 660
gagactggta aaaaagagac aatcgaggaa tga                              693

<210> 43
<211> 424
<212> PRT
<213> Homo sapiens

<400> 43
Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg
 1               5                  10                  15      
Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr
            20                  25                  30          
Met Ala Glu Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His Pro
        35                  40                  45              
Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys
    50                  55                  60                  
Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala
65                  70                  75                  80  
Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly
                85                  90                  95      
Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu
            100                 105                 110         
Arg Phe Arg Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp
        115                 120                 125             
Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val
    130                 135                 140                 
Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala
145                 150                 155                 160 
Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr
                165                 170                 175     
Val Asn Val Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala
            180                 185                 190         
Tyr Lys Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp
        195                 200                 205             
Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu
    210                 215                 220                 
Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met
225                 230                 235                 240 
Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val
                245                 250                 255     
Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr
            260                 265                 270         
Val Phe Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr
        275                 280                 285             
Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu
    290                 295                 300                 
Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser
305                 310                 315                 320 
Glu Ala Leu Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser
                325                 330                 335     
Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala
            340                 345                 350         
Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr
        355                 360                 365             
Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile
    370                 375                 380                 
Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr
385                 390                 395                 400 
Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr
                405                 410                 415     
Gly Lys Lys Glu Thr Ile Glu Glu
            420                 


<210> 44
<211> 1275
<212> DNA
<213> Homo sapiens

<400> 44
caaggaaagt tgccttttgc tgctgcccag attggaaatt cttttagaaa tgagatctcc 60
cctcgatctg gactgatcag agtcagagaa ttcacaatgg cagaaattga gcactttgta 120
gatcccagtg agaaagacca ccccaagttc cagaatgtgg cagaccttca cctttatttg 180
tattcagcaa aagcccaggt cagcggacag tccgctcgga aaatgcgcct gggagatgct 240
gttgaacagg gtgtgattaa taacacagta ttaggctatt tcattggccg catctacctc 300
tacctcacga aggttggaat atctccagat aaactccgct tccggcagca catggagaat 360
gagatggccc attatgcctg tgactgttgg gatgcagaat ccaaaacatc ctacggttgg 420
attgagattg ttggatgtgc tgatcgttcc tgttatgacc tctcctgtca tgcacgagcc 480
accaaagtcc cacttgtagc tgagaaacct ctgaaagaac ccaaaacagt caatgttgtt 540
cagtttgaac ccagtaaggg agcaattggt aaggcatata agaaggatgc aaaactggtg 600
atggagtatc ttgccatttg tgatgagtgc tacattacag aaatggagat gctgctgaat 660
gagaaagggg aattcacaat tgaaactgaa gggaaaacat ttcagttaac aaaagacatg 720
atcaatgtga agagattcca gaaaacacta tatgtggaag aagttgttcc gaatgtaatt 780
gaaccttcct tcggcctggg taggatcatg tatacggtat ttgaacatac attccatgta 840
cgagaaggag atgaacagag aacattcttc agtttccctg ctgtagttgc tccattcaaa 900
tgttccgtcc tcccactgag ccaaaaccag gagttcatgc catttgtcaa ggaattatcg 960
gaagccctga ccaggcatgg agtatctcac aaagtagacg attcctctgg gtcaatcgga 1020
aggcgctatg ccaggactga tgagattggc gtggcttttg gtgtcaccat tgactttgac 1080
acagtgaaca agacccccca cactgcaact ctgagggacc gtgactcaat gcggcagata 1140
agagcagaga tctctgagct gcccagcata gtccaagacc tagccaatgg caacatcaca 1200
tgggctgatg tggaggccag gtatcctctg tttgaagggc aagagactgg taaaaaagag 1260
acaatcgagg aatga                                                  1275

<210> 45
<211> 259
<212> PRT
<213> Homo sapiens

<400> 45
Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln
 1               5                  10                  15      
Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala
            20                  25                  30          
Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr
        35                  40                  45              
Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr
    50                  55                  60                  
Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg
65                  70                  75                  80  
Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu
                85                  90                  95      
Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr
            100                 105                 110         
Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro
        115                 120                 125             
Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn
    130                 135                 140                 
Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg
145                 150                 155                 160 
His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg
                165                 170                 175     
Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile
            180                 185                 190         
Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp
        195                 200                 205             
Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser
    210                 215                 220                 
Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu
225                 230                 235                 240 
Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr
                245                 250                 255     
Ile Glu Glu
            


<210> 46
<211> 780
<212> DNA
<213> Homo sapiens

<400> 46
gtagctgaga aacctctgaa agaacccaaa acagtcaatg ttgttcagtt tgaacccagt 60
aagggagcaa ttggtaaggc atataagaag gatgcaaaac tggtgatgga gtatcttgcc 120
atttgtgatg agtgctacat tacagaaatg gagatgctgc tgaatgagaa aggggaattc 180
acaattgaaa ctgaagggaa aacatttcag ttaacaaaag acatgatcaa tgtgaagaga 240
ttccagaaaa cactatatgt ggaagaagtt gttccgaatg taattgaacc ttccttcggc 300
ctgggtagga tcatgtatac ggtatttgaa catacattcc atgtacgaga aggagatgaa 360
cagagaacat tcttcagttt ccctgctgta gttgctccat tcaaatgttc cgtcctccca 420
ctgagccaaa accaggagtt catgccattt gtcaaggaat tatcggaagc cctgaccagg 480
catggagtat ctcacaaagt agacgattcc tctgggtcaa tcggaaggcg ctatgccagg 540
actgatgaga ttggcgtggc ttttggtgtc accattgact ttgacacagt gaacaagacc 600
ccccacactg caactctgag ggaccgtgac tcaatgcggc agataagagc agagatctct 660
gagctgccca gcatagtcca agacctagcc aatggcaaca tcacatgggc tgatgtggag 720
gccaggtatc ctctgtttga agggcaagag actggtaaaa aagagacaat cgaggaatga 780


<210> 47
<211> 20
<212> PRT
<213> Mus musculus

<400> 47
Thr Leu His Val Glu Glu Val Val Pro Ser Val Ile Glu Pro Ser Phe
 1               5                  10                  15      
Gly Leu Gly Arg
            20  


<210> 48
<211> 19
<212> PRT
<213> Mus musculus

<400> 48
Ile Met Tyr Thr Ile Leu Glu His Thr Phe His Val Arg Glu Gly Asp
 1               5                  10                  15      
Glu Gln Arg
            


<210> 49
<211> 13
<212> PRT
<213> Mus musculus

<400> 49
Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys
 1               5                  10              


<210> 50
<211> 81
<212> PRT
<213> Mus musculus

<400> 50
Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val
 1               5                  10                  15      
Lys Glu Leu Ser Glu Ala Leu Thr Arg Asn Gly Val Ser His Lys Val
            20                  25                  30          
Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu
        35                  40                  45              
Ile Gly Val Ala Phe Gly Ile Thr Ile Asp Phe Asp Thr Val Asn Lys
    50                  55                  60                  
Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile
65                  70                  75                  80  
Arg
    


<210> 51
<211> 26
<212> PRT
<213> Mus musculus

<400> 51
Ala Glu Val Ser Glu Leu Pro Asn Val Val Arg Asp Leu Ala Asn Gly
 1               5                  10                  15      
Asn Ile Thr Trp Ala Asp Val Glu Ala Arg
            20                  25      


<210> 52
<211> 159
<212> PRT
<213> Mus musculus

<400> 52
Thr Leu His Val Glu Glu Val Val Pro Ser Val Ile Glu Pro Ser Phe
 1               5                  10                  15      
Gly Leu Gly Arg Ile Met Tyr Thr Ile Leu Glu His Thr Phe His Val
            20                  25                  30          
Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val
        35                  40                  45              
Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe
    50                  55                  60                  
Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg Asn Gly Val
65                  70                  75                  80  
Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala
                85                  90                  95      
Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Ile Thr Ile Asp Phe Asp
            100                 105                 110         
Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser
        115                 120                 125             
Met Arg Gln Ile Arg Ala Glu Val Ser Glu Leu Pro Asn Val Val Arg
    130                 135                 140                 
Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg
145                 150                 155                 


<210> 53
<211> 18
<212> PRT
<213> Mus musculus

<400> 53
Met Glu Leu Leu Leu Ser Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu
 1               5                  10                  15      
Gly Lys
        


<210> 54
<211> 149
<212> PRT
<213> Mus musculus

<400> 54
Thr Phe Gln Leu Thr Lys Asp Met Val Ser Val Lys Arg Phe Gln Lys
 1               5                  10                  15      
Thr Leu His Val Glu Glu Val Val Pro Ser Val Ile Glu Pro Ser Phe
            20                  25                  30          
Gly Leu Gly Arg Ile Met Tyr Thr Ile Leu Glu His Thr Phe His Val
        35                  40                  45              
Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val
    50                  55                  60                  
Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe
65                  70                  75                  80  
Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg Asn Gly Val
                85                  90                  95      
Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala
            100                 105                 110         
Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Ile Thr Ile Asp Phe Asp
        115                 120                 125             
Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser
    130                 135                 140                 
Met Arg Gln Ile Arg
145                 


<210> 55
<211> 26
<212> PRT
<213> Mus musculus

<400> 55
Ala Glu Val Ser Glu Leu Pro Asn Val Val Arg Asp Leu Ala Asn Gly
 1               5                  10                  15      
Asn Ile Thr Trp Ala Asp Val Glu Ala Arg
            20                  25      


<210> 56
<211> 12
<212> PRT
<213> Mus musculus

<400> 56
Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys
 1               5                  10          


<210> 57
<211> 205
<212> PRT
<213> Mus musculus

<400> 57
Met Glu Leu Leu Leu Ser Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu
 1               5                  10                  15      
Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Val Ser Val Lys Arg Phe
            20                  25                  30          
Gln Lys Thr Leu His Val Glu Glu Val Val Pro Ser Val Ile Glu Pro
        35                  40                  45              
Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Ile Leu Glu His Thr Phe
    50                  55                  60                  
His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala
65                  70                  75                  80  
Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln
                85                  90                  95      
Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg Asn
            100                 105                 110         
Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg
        115                 120                 125             
Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Ile Thr Ile Asp
    130                 135                 140                 
Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg
145                 150                 155                 160 
Asp Ser Met Arg Gln Ile Arg Ala Glu Val Ser Glu Leu Pro Asn Val
                165                 170                 175     
Val Arg Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala
            180                 185                 190         
Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys
        195                 200                 205 


<210> 58
<211> 13
<212> PRT
<213> Mus musculus

<400> 58
Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg
 1               5                  10              


<210> 59
<211> 60
<212> PRT
<213> Mus musculus

<400> 59
Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr
 1               5                  10                  15      
Met Ala Glu Ile Glu His Phe Val Asp Pro Thr Glu Lys Asp His Pro
            20                  25                  30          
Lys Phe Gln Ser Val Ala Asp Leu Cys Leu Tyr Leu Tyr Ser Ala Lys
        35                  40                  45              
Ala Gln Val Thr Gly Gln Ser Ala Arg Lys Met Arg
    50                  55                  60  


<210> 60
<211> 21
<212> PRT
<213> Mus musculus

<400> 60
Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Ser Val Leu Gly
 1               5                  10                  15      
Tyr Phe Ile Gly Arg
            20      


<210> 61
<211> 78
<212> PRT
<213> Mus musculus

<400> 61
Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg
 1               5                  10                  15      
Phe Arg Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys
            20                  25                  30          
Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly
        35                  40                  45              
Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr
    50                  55                  60                  
Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys
65                  70                  75              


<210> 62
<211> 16
<212> PRT
<213> Mus musculus

<400> 62
Thr Val Asn Val Val Gln Phe Glu Pro Asn Lys Gly Ala Val Gly Lys
 1               5                  10                  15      


<210> 63
<211> 216
<212> PRT
<213> Mus musculus

<400> 63
Ala Tyr Lys Lys Asp Ala Lys Leu Val Leu Glu Tyr Leu Ser Ala Cys
 1               5                  10                  15      
Asp Glu Cys Tyr Ile Ser Glu Met Glu Leu Leu Leu Ser Glu Lys Gly
            20                  25                  30          
Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp
        35                  40                  45              
Met Val Ser Val Lys Arg Phe Gln Lys Thr Leu His Val Glu Glu Val
    50                  55                  60                  
Val Pro Ser Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr
65                  70                  75                  80  
Thr Ile Leu Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg
                85                  90                  95      
Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val
            100                 105                 110         
Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu
        115                 120                 125             
Ser Glu Ala Leu Thr Arg Asn Gly Val Ser His Lys Val Asp Asp Ser
    130                 135                 140                 
Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val
145                 150                 155                 160 
Ala Phe Gly Ile Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His
                165                 170                 175     
Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu
            180                 185                 190         
Val Ser Glu Leu Pro Asn Val Val Arg Asp Leu Ala Asn Gly Asn Ile
        195                 200                 205             
Thr Trp Ala Asp Val Glu Ala Arg
    210                 215     


<210> 64
<211> 12
<212> PRT
<213> Mus musculus

<400> 64
Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys
 1               5                  10          


<210> 65
<211> 416
<212> PRT
<213> Mus musculus

<400> 65
Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile
 1               5                  10                  15      
Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu
            20                  25                  30          
Ile Glu His Phe Val Asp Pro Thr Glu Lys Asp His Pro Lys Phe Gln
        35                  40                  45              
Ser Val Ala Asp Leu Cys Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val
    50                  55                  60                  
Thr Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln
65                  70                  75                  80  
Gly Val Ile Asn Asn Ser Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr
                85                  90                  95      
Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg
            100                 105                 110         
Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp
        115                 120                 125             
Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala
    130                 135                 140                 
Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val
145                 150                 155                 160 
Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val
                165                 170                 175     
Val Gln Phe Glu Pro Asn Lys Gly Ala Val Gly Lys Ala Tyr Lys Lys
            180                 185                 190         
Asp Ala Lys Leu Val Leu Glu Tyr Leu Ser Ala Cys Asp Glu Cys Tyr
        195                 200                 205             
Ile Ser Glu Met Glu Leu Leu Leu Ser Glu Lys Gly Glu Phe Thr Ile
    210                 215                 220                 
Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Val Ser Val
225                 230                 235                 240 
Lys Arg Phe Gln Lys Thr Leu His Val Glu Glu Val Val Pro Ser Val
                245                 250                 255     
Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Ile Leu Glu
            260                 265                 270         
His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser
        275                 280                 285             
Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser
    290                 295                 300                 
Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu
305                 310                 315                 320 
Thr Arg Asn Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile
                325                 330                 335     
Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Ile
            340                 345                 350         
Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu
        355                 360                 365             
Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Val Ser Glu Leu
    370                 375                 380                 
Pro Asn Val Val Arg Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp
385                 390                 395                 400 
Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys
                405                 410                 415     


<210> 66
<211> 16
<212> PRT
<213> Mus musculus

<400> 66
Thr Val Asn Val Val Gln Phe Glu Pro Asn Lys Gly Ala Val Gly Lys
 1               5                  10                  15      


<210> 67
<211> 31
<212> PRT
<213> Mus musculus

<400> 67
Ala Tyr Lys Lys Asp Ala Lys Leu Val Leu Glu Tyr Leu Ser Ala Cys
 1               5                  10                  15      
Asp Glu Cys Tyr Ile Ser Glu Met Glu Leu Leu Leu Ser Glu Lys
            20                  25                  30      


<210> 68
<211> 10
<212> PRT
<213> Mus musculus

<400> 68
Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys
 1               5                  10  


<210> 69
<211> 16
<212> PRT
<213> Mus musculus

<400> 69
Thr Phe Gln Leu Thr Lys Asp Met Val Ser Val Lys Arg Phe Gln Lys
 1               5                  10                  15      


<210> 70
<211> 20
<212> PRT
<213> Mus musculus

<400> 70
Thr Leu His Val Glu Glu Val Val Pro Ser Val Ile Glu Pro Ser Phe
 1               5                  10                  15      
Gly Leu Gly Arg
            20  


<210> 71
<211> 19
<212> PRT
<213> Mus musculus

<400> 71
Ile Met Tyr Thr Ile Leu Glu His Thr Phe His Val Arg Glu Gly Asp
 1               5                  10                  15      
Glu Gln Arg
            


<210> 72
<211> 13
<212> PRT
<213> Mus musculus

<400> 72
Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys
 1               5                  10              


<210> 73
<211> 17
<212> PRT
<213> Mus musculus

<400> 73
Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val
 1               5                  10                  15      
Lys
    


<210> 74
<211> 75
<212> PRT
<213> Mus musculus

<400> 74
Glu Leu Ser Glu Ala Leu Thr Arg Asn Gly Val Ser His Lys Val Asp
 1               5                  10                  15      
Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile
            20                  25                  30          
Gly Val Ala Phe Gly Ile Thr Ile Asp Phe Asp Thr Val Asn Lys Thr
        35                  40                  45              
Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg
    50                  55                  60                  
Ala Glu Val Ser Glu Leu Pro Asn Val Val Arg
65                  70                  75  


<210> 75
<211> 15
<212> PRT
<213> Mus musculus

<400> 75
Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg
 1               5                  10                  15  


<210> 76
<211> 232
<212> PRT
<213> Mus musculus

<400> 76
Thr Val Asn Val Val Gln Phe Glu Pro Asn Lys Gly Ala Val Gly Lys
 1               5                  10                  15      
Ala Tyr Lys Lys Asp Ala Lys Leu Val Leu Glu Tyr Leu Ser Ala Cys
            20                  25                  30          
Asp Glu Cys Tyr Ile Ser Glu Met Glu Leu Leu Leu Ser Glu Lys Gly
        35                  40                  45              
Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp
    50                  55                  60                  
Met Val Ser Val Lys Arg Phe Gln Lys Thr Leu His Val Glu Glu Val
65                  70                  75                  80  
Val Pro Ser Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr
                85                  90                  95      
Thr Ile Leu Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg
            100                 105                 110         
Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val
        115                 120                 125             
Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu
    130                 135                 140                 
Ser Glu Ala Leu Thr Arg Asn Gly Val Ser His Lys Val Asp Asp Ser
145                 150                 155                 160 
Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val
                165                 170                 175     
Ala Phe Gly Ile Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His
            180                 185                 190         
Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu
        195                 200                 205             
Val Ser Glu Leu Pro Asn Val Val Arg Asp Leu Ala Asn Gly Asn Ile
    210                 215                 220                 
Thr Trp Ala Asp Val Glu Ala Arg
225                 230         


<210> 77
<211> 176
<212> PRT
<213> Homo sapiens

<400> 77
Met Arg Lys Val Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe
 1               5                  10                  15      
Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe His Val
            20                  25                  30          
Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val
        35                  40                  45              
Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe
    50                  55                  60                  
Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val
65                  70                  75                  80  
Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala
                85                  90                  95      
Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp
            100                 105                 110         
Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser
        115                 120                 125             
Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln
    130                 135                 140                 
Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr
145                 150                 155                 160 
Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu
                165                 170                 175     


<210> 78
<211> 531
<212> DNA
<213> Homo sapiens

<400> 78
atgagaaagg tggaagaagt tgttccgaat gtaattgaac cttccttcgg cctgggtagg 60
atcatgtata cggtatttga acatacattc catgtacgag aaggagatga acagagaaca 120
ttcttcagtt tccctgctgt agttgctcca ttcaaatgtt ccgtcctccc actgagccaa 180
aaccaggagt tcatgccatt tgtcaaggaa ttatcggaag ccctgaccag gcatggagta 240
tctcacaaag tagacgattc ctctgggtca atcggaaggc gctatgccag gactgatgag 300
attggcgtgg cttttggtgt caccattgac tttgacacag tgaacaagac cccccacact 360
gcaactctga gggaccgtga ctcaatgcgg cagataagag cagagatctc tgagctgccc 420
agcatagtcc aagacctagc caatggcaac atcacatggg ctgatgtgga ggccaggtat 480
cctctgtttg aagggcaaga gactggtaaa aaagagacaa tcgaggaatg a          531

<210> 79
<211> 48
<212> PRT
<213> Homo sapiens

<400> 79
Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln
 1               5                  10                  15      
Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr
            20                  25                  30          
Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu
        35                  40                  45              


<210> 80
<211> 147
<212> DNA
<213> Homo sapiens

<400> 80
atgcggcaga taagagcaga gatctctgag ctgcccagca tagtccaaga cctagccaat 60
ggcaacatca catgggctga tgtggaggcc aggtatcctc tgtttgaagg gcaagagact 120
ggtaaaaaag agacaatcga ggaatga                                     147

<210> 81
<211> 514
<212> PRT
<213> Homo sapiens

<400> 81
Met Ser Asp Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu Ser
 1               5                  10                  15      
Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu
            20                  25                  30          
Phe Val Asn Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu Ser
        35                  40                  45              
Pro Pro Val Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro Gly
    50                  55                  60                  
Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe
65                  70                  75                  80  
Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe
                85                  90                  95      
Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg
            100                 105                 110         
Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu His
        115                 120                 125             
Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala
    130                 135                 140                 
Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln
145                 150                 155                 160 
Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile
                165                 170                 175     
Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu
            180                 185                 190         
Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met
        195                 200                 205             
Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser
    210                 215                 220                 
Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser
225                 230                 235                 240 
Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu Val
                245                 250                 255     
Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe
            260                 265                 270         
Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys
        275                 280                 285             
Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu
    290                 295                 300                 
Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu
305                 310                 315                 320 
Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe
                325                 330                 335     
Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu Pro
            340                 345                 350         
Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe
        355                 360                 365             
His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala
    370                 375                 380                 
Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln
385                 390                 395                 400 
Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His
                405                 410                 415     
Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg
            420                 425                 430         
Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp
        435                 440                 445             
Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg
    450                 455                 460                 
Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile
465                 470                 475                 480 
Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala
                485                 490                 495     
Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile
            500                 505                 510         
Glu Glu
        


<210> 82
<211> 1545
<212> DNA
<213> Homo sapiens

<400> 82
atgtctgata agaagtgttc tgtcgaaaag aaatcagaaa tggaaagtgt tttggcccag 60
cttgataact atggacagca agaacttgcg gatctttttg tgaactataa tgtaaaatct 120
cccattactg gaaatgatct atcccctcca gtgtctttta acttaatgtt caagactttc 180
attgggcctg gaggaaacat gcctgggtac ttgagaccag aaactgcaca ggggattttc 240
ttgaatttca aacgactttt ggagttcaac caaggaaagt tgccttttgc tgctgcccag 300
attggaaatt cttttagaaa tgagatctcc cctcgatctg gactgatcag agtcagagaa 360
ttcacaatgg cagaaattga gcactttgta gatcccagtg agaaagacca ccccaagttc 420
cagaatgtgg cagaccttca cctttatttg tattcagcaa aagcccaggt cagcggacag 480
tccgctcgga aaatgcgcct gggagatgct gttgaacagg gtgtgattaa taacacagta 540
ttaggctatt tcattggccg catctacctc tacctcacga aggttggaat atctccagat 600
aaactccgct tccggcagca catggagaat gagatggccc attatgcctg tgactgttgg 660
gatgcagaat ccaaaacatc ctacggttgg attgagattg ttggatgtgc tgatcgttcc 720
tgttatgacc tctcctgtca tgcacgagcc accaaagtcc cacttgtagc tgagaaacct 780
ctgaaagaac ccaaaacagt caatgttgtt cagtttgaac ccagtaaggg agcaattggt 840
aaggcatata agaaggatgc aaaactggtg atggagtatc ttgccatttg tgatgagtgc 900
tacattacag aaatggagat gctgctgaat gagaaagggg aattcacaat tgaaactgaa 960
gggaaaacat ttcagttaac aaaagacatg atcaatgtga agagattcca gaaaacacta 1020
tatgtggaag aagttgttcc gaatgtaatt gaaccttcct tcggcctggg taggatcatg 1080
tatacggtat ttgaacatac attccatgta cgagaaggag atgaacagag aacattcttc 1140
agtttccctg ctgtagttgc tccattcaaa tgttccgtcc tcccactgag ccaaaaccag 1200
gagttcatgc catttgtcaa ggaattatcg gaagccctga ccaggcatgg agtatctcac 1260
aaagtagacg attcctctgg gtcaatcgga aggcgctatg ccaggactga tgagattggc 1320
gtggcttttg gtgtcaccat tgactttgac acagtgaaca agacccccca cactgcaact 1380
ctgagggacc gtgactcaat gcggcagata agagcagaga tctctgagct gcccagcata 1440
gtccaagacc tagccaatgg caacatcaca tgggctgatg tggaggccag gtatcctctg 1500
tttgaagggc aagagactgg taaaaaagag acaatcgagg aatga                 1545

<210> 83
<211> 50
<212> DNA
<213> Homo sapiens

<400> 83
tggagatgct gctgaatgag aaaggtggaa gaagttgttc cgaatgtaat            50

<210> 84
<211> 11
<212> PRT
<213> Homo sapiens

<400> 84
Met Arg Lys Val Glu Glu Val Val Pro Asn Val
 1               5                  10      


<210> 85
<211> 50
<212> DNA
<213> Homo sapiens

<400> 85
acgagaagga gatgaacaga gaacacggaa gccctgacca ggcatggagt            50

<210> 86
<211> 50
<212> DNA
<213> Homo sapiens

<400> 86
tgctcacccc tgagccagtt ttaaactcat ttacagaaat tgatgtctga            50

<210> 87
<211> 2
<212> PRT
<213> Homo sapiens

<400> 87
Met Ser
 1      


<210> 88
<211> 472
<212> PRT
<213> Homo sapiens

<400> 88
Thr Gly Asn Asp Leu Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys
 1               5                  10                  15      
Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu
            20                  25                  30          
Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn
        35                  40                  45              
Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg
    50                  55                  60                  
Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr
65                  70                  75                  80  
Met Ala Glu Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His Pro
                85                  90                  95      
Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys
            100                 105                 110         
Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala
        115                 120                 125             
Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly
    130                 135                 140                 
Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu
145                 150                 155                 160 
Arg Phe Arg Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp
                165                 170                 175     
Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val
            180                 185                 190         
Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala
        195                 200                 205             
Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr
    210                 215                 220                 
Val Asn Val Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala
225                 230                 235                 240 
Tyr Lys Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp
                245                 250                 255     
Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu
            260                 265                 270         
Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met
        275                 280                 285             
Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val
    290                 295                 300                 
Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr
305                 310                 315                 320 
Val Phe Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr
                325                 330                 335     
Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu
            340                 345                 350         
Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser
        355                 360                 365             
Glu Ala Leu Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser
    370                 375                 380                 
Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala
385                 390                 395                 400 
Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr
                405                 410                 415     
Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile
            420                 425                 430         
Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr
        435                 440                 445             
Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr
    450                 455                 460                 
Gly Lys Lys Glu Thr Ile Glu Glu
465                 470         


<210> 89
<211> 1419
<212> DNA
<213> Homo sapiens

<400> 89
actggaaatg atctatcccc tccagtgtct tttaacttaa tgttcaagac tttcattggg 60
cctggaggaa acatgcctgg gtacttgaga ccagaaactg cacaggggat tttcttgaat 120
ttcaaacgac ttttggagtt caaccaagga aagttgcctt ttgctgctgc ccagattgga 180
aattctttta gaaatgagat ctcccctcga tctggactga tcagagtcag agaattcaca 240
atggcagaaa ttgagcactt tgtagatccc agtgagaaag accaccccaa gttccagaat 300
gtggcagacc ttcaccttta tttgtattca gcaaaagccc aggtcagcgg acagtccgct 360
cggaaaatgc gcctgggaga tgctgttgaa cagggtgtga ttaataacac agtattaggc 420
tatttcattg gccgcatcta cctctacctc acgaaggttg gaatatctcc agataaactc 480
cgcttccggc agcacatgga gaatgagatg gcccattatg cctgtgactg ttgggatgca 540
gaatccaaaa catcctacgg ttggattgag attgttggat gtgctgatcg ttcctgttat 600
gacctctcct gtcatgcacg agccaccaaa gtcccacttg tagctgagaa acctctgaaa 660
gaacccaaaa cagtcaatgt tgttcagttt gaacccagta agggagcaat tggtaaggca 720
tataagaagg atgcaaaact ggtgatggag tatcttgcca tttgtgatga gtgctacatt 780
acagaaatgg agatgctgct gaatgagaaa ggggaattca caattgaaac tgaagggaaa 840
acatttcagt taacaaaaga catgatcaat gtgaagagat tccagaaaac actatatgtg 900
gaagaagttg ttccgaatgt aattgaacct tccttcggcc tgggtaggat catgtatacg 960
gtatttgaac atacattcca tgtacgagaa ggagatgaac agagaacatt cttcagtttc 1020
cctgctgtag ttgctccatt caaatgttcc gtcctcccac tgagccaaaa ccaggagttc 1080
atgccatttg tcaaggaatt atcggaagcc ctgaccaggc atggagtatc tcacaaagta 1140
gacgattcct ctgggtcaat cggaaggcgc tatgccagga ctgatgagat tggcgtggct 1200
tttggtgtca ccattgactt tgacacagtg aacaagaccc cccacactgc aactctgagg 1260
gaccgtgact caatgcggca gataagagca gagatctctg agctgcccag catagtccaa 1320
gacctagcca atggcaacat cacatgggct gatgtggagg ccaggtatcc tctgtttgaa 1380
gggcaagaga ctggtaaaaa agagacaatc gaggaatga                        1419

<210> 90
<211> 629
<212> PRT
<213> Homo sapiens

<400> 90
Ala Leu Gln Pro Lys Asp Asp Ile Val Asp Arg Ala Lys Met Glu Asp
 1               5                  10                  15      
Thr Leu Lys Arg Arg Phe Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly
            20                  25                  30          
Gly Val Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly Cys Ala Leu Lys
        35                  40                  45              
Asn Asn Ile Ile Gln Thr Trp Arg Gln His Phe Ile Gln Glu Glu Gln
    50                  55                  60                  
Ile Leu Glu Ile Asp Cys Thr Met Leu Thr Pro Glu Pro Val Leu Lys
65                  70                  75                  80  
Thr Ser Gly His Val Asp Lys Phe Ala Asp Phe Met Val Lys Asp Val
                85                  90                  95      
Lys Asn Gly Glu Cys Phe Arg Ala Asp His Leu Leu Lys Ala His Leu
            100                 105                 110         
Gln Lys Leu Met Ser Asp Lys Lys Cys Ser Val Glu Lys Lys Ser Glu
        115                 120                 125             
Met Glu Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu
    130                 135                 140                 
Ala Asp Leu Phe Val Asn Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn
145                 150                 155                 160 
Asp Leu Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys Thr Phe Ile
                165                 170                 175     
Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln
            180                 185                 190         
Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys
        195                 200                 205             
Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile
    210                 215                 220                 
Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu
225                 230                 235                 240 
Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln
                245                 250                 255     
Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val
            260                 265                 270         
Ser Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln
        275                 280                 285             
Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr
    290                 295                 300                 
Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg
305                 310                 315                 320 
Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp
                325                 330                 335     
Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala
            340                 345                 350         
Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val
        355                 360                 365             
Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val
    370                 375                 380                 
Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys
385                 390                 395                 400 
Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr
                405                 410                 415     
Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile
            420                 425                 430         
Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val
        435                 440                 445             
Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn Val
    450                 455                 460                 
Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu
465                 470                 475                 480 
His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser
                485                 490                 495     
Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser
            500                 505                 510         
Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu
        515                 520                 525             
Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile
    530                 535                 540                 
Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val
545                 550                 555                 560 
Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu
                565                 570                 575     
Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu
            580                 585                 590         
Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp
        595                 600                 605             
Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys
    610                 615                 620                 
Glu Thr Ile Glu Glu
625                 


<210> 91
<211> 1890
<212> DNA
<213> Homo sapiens

<400> 91
gcgttacagc ccaaagatga tattgtagac cgagcaaaaa tggaagatac cctgaagagg 60
aggtttttct atgatcaagc ttttgctatt tatggaggtg ttagtggtct gtatgacttt 120
gggccagttg gctgtgcttt gaagaacaat attattcaga cctggaggca gcactttatc 180
caagaggaac agatcctgga gatcgattgc accatgctca cccctgagcc agttttaaag 240
acctctggcc atgtagacaa atttgctgac ttcatggtga aagacgtaaa aaatggagaa 300
tgttttcgtg ctgaccatct attaaaagct catttacaga aattgatgtc tgataagaag 360
tgttctgtcg aaaagaaatc agaaatggaa agtgttttgg cccagcttga taactatgga 420
cagcaagaac ttgcggatct ttttgtgaac tataatgtaa aatctcccat tactggaaat 480
gatctatccc ctccagtgtc ttttaactta atgttcaaga ctttcattgg gcctggagga 540
aacatgcctg ggtacttgag accagaaact gcacagggga ttttcttgaa tttcaaacga 600
cttttggagt tcaaccaagg aaagttgcct tttgctgctg cccagattgg aaattctttt 660
agaaatgaga tctcccctcg atctggactg atcagagtca gagaattcac aatggcagaa 720
attgagcact ttgtagatcc cagtgagaaa gaccacccca agttccagaa tgtggcagac 780
cttcaccttt atttgtattc agcaaaagcc caggtcagcg gacagtccgc tcggaaaatg 840
cgcctgggag atgctgttga acagggtgtg attaataaca cagtattagg ctatttcatt 900
ggccgcatct acctctacct cacgaaggtt ggaatatctc cagataaact ccgcttccgg 960
cagcacatgg agaatgagat ggcccattat gcctgtgact gttgggatgc agaatccaaa 1020
acatcctacg gttggattga gattgttgga tgtgctgatc gttcctgtta tgacctctcc 1080
tgtcatgcac gagccaccaa agtcccactt gtagctgaga aacctctgaa agaacccaaa 1140
acagtcaatg ttgttcagtt tgaacccagt aagggagcaa ttggtaaggc atataagaag 1200
gatgcaaaac tggtgatgga gtatcttgcc atttgtgatg agtgctacat tacagaaatg 1260
gagatgctgc tgaatgagaa aggggaattc acaattgaaa ctgaagggaa aacatttcag 1320
ttaacaaaag acatgatcaa tgtgaagaga ttccagaaaa cactatatgt ggaagaagtt 1380
gttccgaatg taattgaacc ttccttcggc ctgggtagga tcatgtatac ggtatttgaa 1440
catacattcc atgtacgaga aggagatgaa cagagaacat tcttcagttt ccctgctgta 1500
gttgctccat tcaaatgttc cgtcctccca ctgagccaaa accaggagtt catgccattt 1560
gtcaaggaat tatcggaagc cctgaccagg catggagtat ctcacaaagt agacgattcc 1620
tctgggtcaa tcggaaggcg ctatgccagg actgatgaga ttggcgtggc ttttggtgtc 1680
accattgact ttgacacagt gaacaagacc ccccacactg caactctgag ggaccgtgac 1740
tcaatgcggc agataagagc agagatctct gagctgccca gcatagtcca agacctagcc 1800
aatggcaaca tcacatgggc tgatgtggag gccaggtatc ctctgtttga agggcaagag 1860
actggtaaaa aagagacaat cgaggaatga                                  1890

<210> 92
<211> 247
<212> PRT
<213> Homo sapiens

<400> 92
Asn Val Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr
 1               5                  10                  15      
Lys Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu
            20                  25                  30          
Cys Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe
        35                  40                  45              
Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile
    50                  55                  60                  
Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro
65                  70                  75                  80  
Asn Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val
                85                  90                  95      
Phe Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe
            100                 105                 110         
Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro
        115                 120                 125             
Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu
    130                 135                 140                 
Ala Leu Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly
145                 150                 155                 160 
Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe
                165                 170                 175     
Gly Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala
            180                 185                 190         
Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser
        195                 200                 205             
Glu Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp
    210                 215                 220                 
Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly
225                 230                 235                 240 
Lys Lys Glu Thr Ile Glu Glu
                245         


<210> 93
<211> 744
<212> DNA
<213> Homo sapiens

<400> 93
aatgttgttc agtttgaacc cagtaaggga gcaattggta aggcatataa gaaggatgca 60
aaactggtga tggagtatct tgccatttgt gatgagtgct acattacaga aatggagatg 120
ctgctgaatg agaaagggga attcacaatt gaaactgaag ggaaaacatt tcagttaaca 180
aaagacatga tcaatgtgaa gagattccag aaaacactat atgtggaaga agttgttccg 240
aatgtaattg aaccttcctt cggcctgggt aggatcatgt atacggtatt tgaacataca 300
ttccatgtac gagaaggaga tgaacagaga acattcttca gtttccctgc tgtagttgct 360
ccattcaaat gttccgtcct cccactgagc caaaaccagg agttcatgcc atttgtcaag 420
gaattatcgg aagccctgac caggcatgga gtatctcaca aagtagacga ttcctctggg 480
tcaatcggaa ggcgctatgc caggactgat gagattggcg tggcttttgg tgtcaccatt 540
gactttgaca cagtgaacaa gaccccccac actgcaactc tgagggaccg tgactcaatg 600
cggcagataa gagcagagat ctctgagctg cccagcatag tccaagacct agccaatggc 660
aacatcacat gggctgatgt ggaggccagg tatcctctgt ttgaagggca agagactggt 720
aaaaaagaga caatcgagga atga                                        744

<210> 94
<211> 175
<212> PRT
<213> Homo sapiens

<400> 94
Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly
 1               5                  10                  15      
Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe His Val Arg
            20                  25                  30          
Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val Ala
        35                  40                  45              
Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met
    50                  55                  60                  
Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val Ser
65                  70                  75                  80  
His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg
                85                  90                  95      
Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp Thr
            100                 105                 110         
Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met
        115                 120                 125             
Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln Asp
    130                 135                 140                 
Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro
145                 150                 155                 160 
Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu
                165                 170                 175 


<210> 95
<211> 528
<212> DNA
<213> Homo sapiens

<400> 95
ctatatgtgg aagaagttgt tccgaatgta attgaacctt ccttcggcct gggtaggatc 60
atgtatacgg tatttgaaca tacattccat gtacgagaag gagatgaaca gagaacattc 120
ttcagtttcc ctgctgtagt tgctccattc aaatgttccg tcctcccact gagccaaaac 180
caggagttca tgccatttgt caaggaatta tcggaagccc tgaccaggca tggagtatct 240
cacaaagtag acgattcctc tgggtcaatc ggaaggcgct atgccaggac tgatgagatt 300
ggcgtggctt ttggtgtcac cattgacttt gacacagtga acaagacccc ccacactgca 360
actctgaggg accgtgactc aatgcggcag ataagagcag agatctctga gctgcccagc 420
atagtccaag acctagccaa tggcaacatc acatgggctg atgtggaggc caggtatcct 480
ctgtttgaag ggcaagagac tggtaaaaaa gagacaatcg aggaatga              528

<210> 96
<211> 371
<212> PRT
<213> Homo sapiens

<400> 96
Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly
 1               5                  10                  15      
Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val
            20                  25                  30          
Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr
        35                  40                  45              
Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His
    50                  55                  60                  
Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu
65                  70                  75                  80  
Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg
                85                  90                  95      
Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu
            100                 105                 110         
Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln
        115                 120                 125             
Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala
    130                 135                 140                 
Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr
145                 150                 155                 160 
Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr
                165                 170                 175     
Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg
            180                 185                 190         
Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu
        195                 200                 205             
Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr
    210                 215                 220                 
Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro
225                 230                 235                 240 
Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn
                245                 250                 255     
Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg
            260                 265                 270         
His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg
        275                 280                 285             
Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile
    290                 295                 300                 
Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp
305                 310                 315                 320 
Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser
                325                 330                 335     
Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu
            340                 345                 350         
Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr
        355                 360                 365             
Ile Glu Glu
    370     


<210> 97
<211> 1116
<212> DNA
<213> Homo sapiens

<400> 97
gcagaccttc acctttattt gtattcagca aaagcccagg tcagcggaca gtccgctcgg 60
aaaatgcgcc tgggagatgc tgttgaacag ggtgtgatta ataacacagt attaggctat 120
ttcattggcc gcatctacct ctacctcacg aaggttggaa tatctccaga taaactccgc 180
ttccggcagc acatggagaa tgagatggcc cattatgcct gtgactgttg ggatgcagaa 240
tccaaaacat cctacggttg gattgagatt gttggatgtg ctgatcgttc ctgttatgac 300
ctctcctgtc atgcacgagc caccaaagtc ccacttgtag ctgagaaacc tctgaaagaa 360
cccaaaacag tcaatgttgt tcagtttgaa cccagtaagg gagcaattgg taaggcatat 420
aagaaggatg caaaactggt gatggagtat cttgccattt gtgatgagtg ctacattaca 480
gaaatggaga tgctgctgaa tgagaaaggg gaattcacaa ttgaaactga agggaaaaca 540
tttcagttaa caaaagacat gatcaatgtg aagagattcc agaaaacact atatgtggaa 600
gaagttgttc cgaatgtaat tgaaccttcc ttcggcctgg gtaggatcat gtatacggta 660
tttgaacata cattccatgt acgagaagga gatgaacaga gaacattctt cagtttccct 720
gctgtagttg ctccattcaa atgttccgtc ctcccactga gccaaaacca ggagttcatg 780
ccatttgtca aggaattatc ggaagccctg accaggcatg gagtatctca caaagtagac 840
gattcctctg ggtcaatcgg aaggcgctat gccaggactg atgagattgg cgtggctttt 900
ggtgtcacca ttgactttga cacagtgaac aagacccccc acactgcaac tctgagggac 960
cgtgactcaa tgcggcagat aagagcagag atctctgagc tgcccagcat agtccaagac 1020
ctagccaatg gcaacatcac atgggctgat gtggaggcca ggtatcctct gtttgaaggg 1080
caagagactg gtaaaaaaga gacaatcgag gaatga                           1116

<210> 98
<211> 353
<212> PRT
<213> Homo sapiens

<400> 98
Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn
 1               5                  10                  15      
Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr
            20                  25                  30          
Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu
        35                  40                  45              
Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys
    50                  55                  60                  
Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys
65                  70                  75                  80  
Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu Val Ala
                85                  90                  95      
Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu
            100                 105                 110         
Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu
        115                 120                 125             
Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met
    130                 135                 140                 
Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly
145                 150                 155                 160 
Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe Gln
                165                 170                 175     
Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser
            180                 185                 190         
Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe His
        195                 200                 205             
Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val
    210                 215                 220                 
Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu
225                 230                 235                 240 
Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly
                245                 250                 255     
Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr
            260                 265                 270         
Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe
        275                 280                 285             
Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp
    290                 295                 300                 
Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val
305                 310                 315                 320 
Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg
                325                 330                 335     
Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu
            340                 345                 350         
Glu
    


<210> 99
<211> 1062
<212> DNA
<213> Homo sapiens

<400> 99
gctcggaaaa tgcgcctggg agatgctgtt gaacagggtg tgattaataa cacagtatta 60
ggctatttca ttggccgcat ctacctctac ctcacgaagg ttggaatatc tccagataaa 120
ctccgcttcc ggcagcacat ggagaatgag atggcccatt atgcctgtga ctgttgggat 180
gcagaatcca aaacatccta cggttggatt gagattgttg gatgtgctga tcgttcctgt 240
tatgacctct cctgtcatgc acgagccacc aaagtcccac ttgtagctga gaaacctctg 300
aaagaaccca aaacagtcaa tgttgttcag tttgaaccca gtaagggagc aattggtaag 360
gcatataaga aggatgcaaa actggtgatg gagtatcttg ccatttgtga tgagtgctac 420
attacagaaa tggagatgct gctgaatgag aaaggggaat tcacaattga aactgaaggg 480
aaaacatttc agttaacaaa agacatgatc aatgtgaaga gattccagaa aacactatat 540
gtggaagaag ttgttccgaa tgtaattgaa ccttccttcg gcctgggtag gatcatgtat 600
acggtatttg aacatacatt ccatgtacga gaaggagatg aacagagaac attcttcagt 660
ttccctgctg tagttgctcc attcaaatgt tccgtcctcc cactgagcca aaaccaggag 720
ttcatgccat ttgtcaagga attatcggaa gccctgacca ggcatggagt atctcacaaa 780
gtagacgatt cctctgggtc aatcggaagg cgctatgcca ggactgatga gattggcgtg 840
gcttttggtg tcaccattga ctttgacaca gtgaacaaga ccccccacac tgcaactctg 900
agggaccgtg actcaatgcg gcagataaga gcagagatct ctgagctgcc cagcatagtc 960
caagacctag ccaatggcaa catcacatgg gctgatgtgg aggccaggta tcctctgttt 1020
gaagggcaag agactggtaa aaaagagaca atcgaggaat ga                    1062

<210> 100
<211> 558
<212> PRT
<213> Homo sapiens

<400> 100
Met Leu Thr Pro Glu Pro Val Leu Lys Thr Ser Gly His Val Asp Lys
 1               5                  10                  15      
Phe Ala Asp Phe Met Val Lys Asp Val Lys Asn Gly Glu Cys Phe Arg
            20                  25                  30          
Ala Asp His Leu Leu Lys Ala His Leu Gln Lys Leu Met Ser Asp Lys
        35                  40                  45              
Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu Ser Val Leu Ala Gln
    50                  55                  60                  
Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr
65                  70                  75                  80  
Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu Ser Pro Pro Val Ser
                85                  90                  95      
Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro Gly Gly Asn Met Pro
            100                 105                 110         
Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys
        115                 120                 125             
Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln
    130                 135                 140                 
Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile
145                 150                 155                 160 
Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp Pro
                165                 170                 175     
Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His Leu
            180                 185                 190         
Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg Lys
        195                 200                 205             
Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr Val
    210                 215                 220                 
Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly
225                 230                 235                 240 
Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu Met
                245                 250                 255     
Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr
            260                 265                 270         
Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu
        275                 280                 285             
Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu Lys Pro
    290                 295                 300                 
Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro Ser Lys
305                 310                 315                 320 
Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val Met Glu
                325                 330                 335     
Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met Leu
            340                 345                 350         
Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe
        355                 360                 365             
Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe Gln Lys Thr Leu
    370                 375                 380                 
Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly Leu
385                 390                 395                 400 
Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe His Val Arg Glu
                405                 410                 415     
Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro
            420                 425                 430         
Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro
        435                 440                 445             
Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val Ser His
    450                 455                 460                 
Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr
465                 470                 475                 480 
Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp Thr Val
                485                 490                 495     
Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg
            500                 505                 510         
Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln Asp Leu
        515                 520                 525             
Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu
    530                 535                 540                 
Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu
545                 550                 555             


<210> 101
<211> 1677
<212> DNA
<213> Homo sapiens

<400> 101
atgctcaccc ctgagccagt tttaaagacc tctggccatg tagacaaatt tgctgacttc 60
atggtgaaag acgtaaaaaa tggagaatgt tttcgtgctg accatctatt aaaagctcat 120
ttacagaaat tgatgtctga taagaagtgt tctgtcgaaa agaaatcaga aatggaaagt 180
gttttggccc agcttgataa ctatggacag caagaacttg cggatctttt tgtgaactat 240
aatgtaaaat ctcccattac tggaaatgat ctatcccctc cagtgtcttt taacttaatg 300
ttcaagactt tcattgggcc tggaggaaac atgcctgggt acttgagacc agaaactgca 360
caggggattt tcttgaattt caaacgactt ttggagttca accaaggaaa gttgcctttt 420
gctgctgccc agattggaaa ttcttttaga aatgagatct cccctcgatc tggactgatc 480
agagtcagag aattcacaat ggcagaaatt gagcactttg tagatcccag tgagaaagac 540
caccccaagt tccagaatgt ggcagacctt cacctttatt tgtattcagc aaaagcccag 600
gtcagcggac agtccgctcg gaaaatgcgc ctgggagatg ctgttgaaca gggtgtgatt 660
aataacacag tattaggcta tttcattggc cgcatctacc tctacctcac gaaggttgga 720
atatctccag ataaactccg cttccggcag cacatggaga atgagatggc ccattatgcc 780
tgtgactgtt gggatgcaga atccaaaaca tcctacggtt ggattgagat tgttggatgt 840
gctgatcgtt cctgttatga cctctcctgt catgcacgag ccaccaaagt cccacttgta 900
gctgagaaac ctctgaaaga acccaaaaca gtcaatgttg ttcagtttga acccagtaag 960
ggagcaattg gtaaggcata taagaaggat gcaaaactgg tgatggagta tcttgccatt 1020
tgtgatgagt gctacattac agaaatggag atgctgctga atgagaaagg ggaattcaca 1080
attgaaactg aagggaaaac atttcagtta acaaaagaca tgatcaatgt gaagagattc 1140
cagaaaacac tatatgtgga agaagttgtt ccgaatgtaa ttgaaccttc cttcggcctg 1200
ggtaggatca tgtatacggt atttgaacat acattccatg tacgagaagg agatgaacag 1260
agaacattct tcagtttccc tgctgtagtt gctccattca aatgttccgt cctcccactg 1320
agccaaaacc aggagttcat gccatttgtc aaggaattat cggaagccct gaccaggcat 1380
ggagtatctc acaaagtaga cgattcctct gggtcaatcg gaaggcgcta tgccaggact 1440
gatgagattg gcgtggcttt tggtgtcacc attgactttg acacagtgaa caagaccccc 1500
cacactgcaa ctctgaggga ccgtgactca atgcggcaga taagagcaga gatctctgag 1560
ctgcccagca tagtccaaga cctagccaat ggcaacatca catgggctga tgtggaggcc 1620
aggtatcctc tgtttgaagg gcaagagact ggtaaaaaag agacaatcga ggaatga    1677

<210> 102
<211> 447
<212> PRT
<213> Homo sapiens

<400> 102
Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe
 1               5                  10                  15      
Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala
            20                  25                  30          
Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu
        35                  40                  45              
Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp
    50                  55                  60                  
Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His
65                  70                  75                  80  
Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg
                85                  90                  95      
Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr
            100                 105                 110         
Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val
        115                 120                 125             
Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu
    130                 135                 140                 
Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser
145                 150                 155                 160 
Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp
                165                 170                 175     
Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu Lys
            180                 185                 190         
Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro Ser
        195                 200                 205             
Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val Met
    210                 215                 220                 
Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met
225                 230                 235                 240 
Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr
                245                 250                 255     
Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe Gln Lys Thr
            260                 265                 270         
Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly
        275                 280                 285             
Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe His Val Arg
    290                 295                 300                 
Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val Ala
305                 310                 315                 320 
Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met
                325                 330                 335     
Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val Ser
            340                 345                 350         
His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg
        355                 360                 365             
Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp Thr
    370                 375                 380                 
Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met
385                 390                 395                 400 
Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln Asp
                405                 410                 415     
Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro
            420                 425                 430         
Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu
        435                 440                 445         


<210> 103
<211> 1344
<212> DNA
<213> Homo sapiens

<400> 103
cctgggtact tgagaccaga aactgcacag gggattttct tgaatttcaa acgacttttg 60
gagttcaacc aaggaaagtt gccttttgct gctgcccaga ttggaaattc ttttagaaat 120
gagatctccc ctcgatctgg actgatcaga gtcagagaat tcacaatggc agaaattgag 180
cactttgtag atcccagtga gaaagaccac cccaagttcc agaatgtggc agaccttcac 240
ctttatttgt attcagcaaa agcccaggtc agcggacagt ccgctcggaa aatgcgcctg 300
ggagatgctg ttgaacaggg tgtgattaat aacacagtat taggctattt cattggccgc 360
atctacctct acctcacgaa ggttggaata tctccagata aactccgctt ccggcagcac 420
atggagaatg agatggccca ttatgcctgt gactgttggg atgcagaatc caaaacatcc 480
tacggttgga ttgagattgt tggatgtgct gatcgttcct gttatgacct ctcctgtcat 540
gcacgagcca ccaaagtccc acttgtagct gagaaacctc tgaaagaacc caaaacagtc 600
aatgttgttc agtttgaacc cagtaaggga gcaattggta aggcatataa gaaggatgca 660
aaactggtga tggagtatct tgccatttgt gatgagtgct acattacaga aatggagatg 720
ctgctgaatg agaaagggga attcacaatt gaaactgaag ggaaaacatt tcagttaaca 780
aaagacatga tcaatgtgaa gagattccag aaaacactat atgtggaaga agttgttccg 840
aatgtaattg aaccttcctt cggcctgggt aggatcatgt atacggtatt tgaacataca 900
ttccatgtac gagaaggaga tgaacagaga acattcttca gtttccctgc tgtagttgct 960
ccattcaaat gttccgtcct cccactgagc caaaaccagg agttcatgcc atttgtcaag 1020
gaattatcgg aagccctgac caggcatgga gtatctcaca aagtagacga ttcctctggg 1080
tcaatcggaa ggcgctatgc caggactgat gagattggcg tggcttttgg tgtcaccatt 1140
gactttgaca cagtgaacaa gaccccccac actgcaactc tgagggaccg tgactcaatg 1200
cggcagataa gagcagagat ctctgagctg cccagcatag tccaagacct agccaatggc 1260
aacatcacat gggctgatgt ggaggccagg tatcctctgt ttgaagggca agagactggt 1320
aaaaaagaga caatcgagga atga                                        1344

<210> 104
<211> 421
<212> PRT
<213> Homo sapiens

<400> 104
Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile
 1               5                  10                  15      
Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu
            20                  25                  30          
Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln
        35                  40                  45              
Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val
    50                  55                  60                  
Ser Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln
65                  70                  75                  80  
Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr
                85                  90                  95      
Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg
            100                 105                 110         
Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp
        115                 120                 125             
Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala
    130                 135                 140                 
Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val
145                 150                 155                 160 
Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val
                165                 170                 175     
Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys
            180                 185                 190         
Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr
        195                 200                 205             
Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile
    210                 215                 220                 
Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val
225                 230                 235                 240 
Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn Val
                245                 250                 255     
Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu
            260                 265                 270         
His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser
        275                 280                 285             
Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser
    290                 295                 300                 
Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu
305                 310                 315                 320 
Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile
                325                 330                 335     
Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val
            340                 345                 350         
Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu
        355                 360                 365             
Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu
    370                 375                 380                 
Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp
385                 390                 395                 400 
Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys
                405                 410                 415     
Glu Thr Ile Glu Glu
            420     


<210> 105
<211> 1266
<212> DNA
<213> Homo sapiens

<400> 105
ttgccttttg ctgctgccca gattggaaat tcttttagaa atgagatctc ccctcgatct 60
ggactgatca gagtcagaga attcacaatg gcagaaattg agcactttgt agatcccagt 120
gagaaagacc accccaagtt ccagaatgtg gcagaccttc acctttattt gtattcagca 180
aaagcccagg tcagcggaca gtccgctcgg aaaatgcgcc tgggagatgc tgttgaacag 240
ggtgtgatta ataacacagt attaggctat ttcattggcc gcatctacct ctacctcacg 300
aaggttggaa tatctccaga taaactccgc ttccggcagc acatggagaa tgagatggcc 360
cattatgcct gtgactgttg ggatgcagaa tccaaaacat cctacggttg gattgagatt 420
gttggatgtg ctgatcgttc ctgttatgac ctctcctgtc atgcacgagc caccaaagtc 480
ccacttgtag ctgagaaacc tctgaaagaa cccaaaacag tcaatgttgt tcagtttgaa 540
cccagtaagg gagcaattgg taaggcatat aagaaggatg caaaactggt gatggagtat 600
cttgccattt gtgatgagtg ctacattaca gaaatggaga tgctgctgaa tgagaaaggg 660
gaattcacaa ttgaaactga agggaaaaca tttcagttaa caaaagacat gatcaatgtg 720
aagagattcc agaaaacact atatgtggaa gaagttgttc cgaatgtaat tgaaccttcc 780
ttcggcctgg gtaggatcat gtatacggta tttgaacata cattccatgt acgagaagga 840
gatgaacaga gaacattctt cagtttccct gctgtagttg ctccattcaa atgttccgtc 900
ctcccactga gccaaaacca ggagttcatg ccatttgtca aggaattatc ggaagccctg 960
accaggcatg gagtatctca caaagtagac gattcctctg ggtcaatcgg aaggcgctat 1020
gccaggactg atgagattgg cgtggctttt ggtgtcacca ttgactttga cacagtgaac 1080
aagacccccc acactgcaac tctgagggac cgtgactcaa tgcggcagat aagagcagag 1140
atctctgagc tgcccagcat agtccaagac ctagccaatg gcaacatcac atgggctgat 1200
gtggaggcca ggtatcctct gtttgaaggg caagagactg gtaaaaaaga gacaatcgag 1260
gaatga                                                            1266

<210> 106
<211> 128
<212> PRT
<213> Homo sapiens

<400> 106
Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe
 1               5                  10                  15      
Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val
            20                  25                  30          
Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala
        35                  40                  45              
Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp
    50                  55                  60                  
Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser
65                  70                  75                  80  
Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln
                85                  90                  95      
Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr
            100                 105                 110         
Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu
        115                 120                 125             


<210> 107
<211> 387
<212> DNA
<213> Homo sapiens

<400> 107
gctccattca aatgttccgt cctcccactg agccaaaacc aggagttcat gccatttgtc 60
aaggaattat cggaagccct gaccaggcat ggagtatctc acaaagtaga cgattcctct 120
gggtcaatcg gaaggcgcta tgccaggact gatgagattg gcgtggcttt tggtgtcacc 180
attgactttg acacagtgaa caagaccccc cacactgcaa ctctgaggga ccgtgactca 240
atgcggcaga taagagcaga gatctctgag ctgcccagca tagtccaaga cctagccaat 300
ggcaacatca catgggctga tgtggaggcc aggtatcctc tgtttgaagg gcaagagact 360
ggtaaaaaag agacaatcga ggaatga                                     387

<210> 108
<211> 504
<212> PRT
<213> Homo sapiens

<400> 108
Lys Ser Glu Met Glu Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln
 1               5                  10                  15      
Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr Asn Val Lys Ser Pro Ile
            20                  25                  30          
Thr Gly Asn Asp Leu Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys
        35                  40                  45              
Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu
    50                  55                  60                  
Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn
65                  70                  75                  80  
Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg
                85                  90                  95      
Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr
            100                 105                 110         
Met Ala Glu Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His Pro
        115                 120                 125             
Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys
    130                 135                 140                 
Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala
145                 150                 155                 160 
Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly
                165                 170                 175     
Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu
            180                 185                 190         
Arg Phe Arg Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp
        195                 200                 205             
Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val
    210                 215                 220                 
Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala
225                 230                 235                 240 
Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr
                245                 250                 255     
Val Asn Val Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala
            260                 265                 270         
Tyr Lys Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp
        275                 280                 285             
Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu
    290                 295                 300                 
Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met
305                 310                 315                 320 
Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val
                325                 330                 335     
Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr
            340                 345                 350         
Val Phe Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr
        355                 360                 365             
Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu
    370                 375                 380                 
Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser
385                 390                 395                 400 
Glu Ala Leu Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser
                405                 410                 415     
Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala
            420                 425                 430         
Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr
        435                 440                 445             
Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile
    450                 455                 460                 
Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr
465                 470                 475                 480 
Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr
                485                 490                 495     
Gly Lys Lys Glu Thr Ile Glu Glu
            500                 


<210> 109
<211> 1515
<212> DNA
<213> Homo sapiens

<400> 109
aaatcagaaa tggaaagtgt tttggcccag cttgataact atggacagca agaacttgcg 60
gatctttttg tgaactataa tgtaaaatct cccattactg gaaatgatct atcccctcca 120
gtgtctttta acttaatgtt caagactttc attgggcctg gaggaaacat gcctgggtac 180
ttgagaccag aaactgcaca ggggattttc ttgaatttca aacgactttt ggagttcaac 240
caaggaaagt tgccttttgc tgctgcccag attggaaatt cttttagaaa tgagatctcc 300
cctcgatctg gactgatcag agtcagagaa ttcacaatgg cagaaattga gcactttgta 360
gatcccagtg agaaagacca ccccaagttc cagaatgtgg cagaccttca cctttatttg 420
tattcagcaa aagcccaggt cagcggacag tccgctcgga aaatgcgcct gggagatgct 480
gttgaacagg gtgtgattaa taacacagta ttaggctatt tcattggccg catctacctc 540
tacctcacga aggttggaat atctccagat aaactccgct tccggcagca catggagaat 600
gagatggccc attatgcctg tgactgttgg gatgcagaat ccaaaacatc ctacggttgg 660
attgagattg ttggatgtgc tgatcgttcc tgttatgacc tctcctgtca tgcacgagcc 720
accaaagtcc cacttgtagc tgagaaacct ctgaaagaac ccaaaacagt caatgttgtt 780
cagtttgaac ccagtaaggg agcaattggt aaggcatata agaaggatgc aaaactggtg 840
atggagtatc ttgccatttg tgatgagtgc tacattacag aaatggagat gctgctgaat 900
gagaaagggg aattcacaat tgaaactgaa gggaaaacat ttcagttaac aaaagacatg 960
atcaatgtga agagattcca gaaaacacta tatgtggaag aagttgttcc gaatgtaatt 1020
gaaccttcct tcggcctggg taggatcatg tatacggtat ttgaacatac attccatgta 1080
cgagaaggag atgaacagag aacattcttc agtttccctg ctgtagttgc tccattcaaa 1140
tgttccgtcc tcccactgag ccaaaaccag gagttcatgc catttgtcaa ggaattatcg 1200
gaagccctga ccaggcatgg agtatctcac aaagtagacg attcctctgg gtcaatcgga 1260
aggcgctatg ccaggactga tgagattggc gtggcttttg gtgtcaccat tgactttgac 1320
acagtgaaca agacccccca cactgcaact ctgagggacc gtgactcaat gcggcagata 1380
agagcagaga tctctgagct gcccagcata gtccaagacc tagccaatgg caacatcaca 1440
tgggctgatg tggaggccag gtatcctctg tttgaagggc aagagactgg taaaaaagag 1500
acaatcgagg aatga                                                  1515

<210> 110
<211> 210
<212> PRT
<213> Homo sapiens

<400> 110
Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu
 1               5                  10                  15      
Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe
            20                  25                  30          
Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu Pro
        35                  40                  45              
Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe
    50                  55                  60                  
His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala
65                  70                  75                  80  
Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln
                85                  90                  95      
Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His
            100                 105                 110         
Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg
        115                 120                 125             
Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp
    130                 135                 140                 
Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg
145                 150                 155                 160 
Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile
                165                 170                 175     
Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala
            180                 185                 190         
Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile
        195                 200                 205             
Glu Glu
    210 


<210> 111
<211> 633
<212> DNA
<213> Homo sapiens

<400> 111
atggagatgc tgctgaatga gaaaggggaa ttcacaattg aaactgaagg gaaaacattt 60
cagttaacaa aagacatgat caatgtgaag agattccaga aaacactata tgtggaagaa 120
gttgttccga atgtaattga accttccttc ggcctgggta ggatcatgta tacggtattt 180
gaacatacat tccatgtacg agaaggagat gaacagagaa cattcttcag tttccctgct 240
gtagttgctc cattcaaatg ttccgtcctc ccactgagcc aaaaccagga gttcatgcca 300
tttgtcaagg aattatcgga agccctgacc aggcatggag tatctcacaa agtagacgat 360
tcctctgggt caatcggaag gcgctatgcc aggactgatg agattggcgt ggcttttggt 420
gtcaccattg actttgacac agtgaacaag accccccaca ctgcaactct gagggaccgt 480
gactcaatgc ggcagataag agcagagatc tctgagctgc ccagcatagt ccaagaccta 540
gccaatggca acatcacatg ggctgatgtg gaggccaggt atcctctgtt tgaagggcaa 600
gagactggta aaaaagagac aatcgaggaa tga                              633

<210> 112
<211> 205
<212> PRT
<213> Homo sapiens

<400> 112
Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln
 1               5                  10                  15      
Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr
            20                  25                  30          
Val Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly
        35                  40                  45              
Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe His Val Arg Glu Gly
    50                  55                  60                  
Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe
65                  70                  75                  80  
Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe
                85                  90                  95      
Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val Ser His Lys
            100                 105                 110         
Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp
        115                 120                 125             
Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn
    130                 135                 140                 
Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln
145                 150                 155                 160 
Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala
                165                 170                 175     
Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe
            180                 185                 190         
Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu
        195                 200                 205 


<210> 113
<211> 618
<212> DNA
<213> Homo sapiens

<400> 113
aatgagaaag gggaattcac aattgaaact gaagggaaaa catttcagtt aacaaaagac 60
atgatcaatg tgaagagatt ccagaaaaca ctatatgtgg aagaagttgt tccgaatgta 120
attgaacctt ccttcggcct gggtaggatc atgtatacgg tatttgaaca tacattccat 180
gtacgagaag gagatgaaca gagaacattc ttcagtttcc ctgctgtagt tgctccattc 240
aaatgttccg tcctcccact gagccaaaac caggagttca tgccatttgt caaggaatta 300
tcggaagccc tgaccaggca tggagtatct cacaaagtag acgattcctc tgggtcaatc 360
ggaaggcgct atgccaggac tgatgagatt ggcgtggctt ttggtgtcac cattgacttt 420
gacacagtga acaagacccc ccacactgca actctgaggg accgtgactc aatgcggcag 480
ataagagcag agatctctga gctgcccagc atagtccaag acctagccaa tggcaacatc 540
acatgggctg atgtggaggc caggtatcct ctgtttgaag ggcaagagac tggtaaaaaa 600
gagacaatcg aggaatga                                               618

<210> 114
<211> 462
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 114
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Gly Ile Phe Leu Asn Phe Lys Arg Leu
            20                  25                  30          
Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly
        35                  40                  45              
Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val
    50                  55                  60                  
Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp Pro Ser Glu
65                  70                  75                  80  
Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr Leu
                85                  90                  95      
Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met Arg
            100                 105                 110         
Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu Gly
        115                 120                 125             
Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser
    130                 135                 140                 
Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu Met Ala His
145                 150                 155                 160 
Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp
                165                 170                 175     
Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys
            180                 185                 190         
His Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys
        195                 200                 205             
Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro Ser Lys Gly Ala
    210                 215                 220                 
Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val Met Glu Tyr Leu
225                 230                 235                 240 
Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu Asn
                245                 250                 255     
Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu
            260                 265                 270         
Thr Lys Asp Met Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr Val
        275                 280                 285             
Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly Arg
    290                 295                 300                 
Ile Met Tyr Thr Val Phe Glu His Thr Phe His Val Arg Glu Gly Asp
305                 310                 315                 320 
Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys
                325                 330                 335     
Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val
            340                 345                 350         
Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val Ser His Lys Val
        355                 360                 365             
Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu
    370                 375                 380                 
Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn Lys
385                 390                 395                 400 
Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile
                405                 410                 415     
Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala Asn
            420                 425                 430         
Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu
        435                 440                 445             
Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu Leu Glu
    450                 455                 460         


<210> 115
<211> 462
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 115
Met Gly Ser Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn
 1               5                  10                  15      
Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg
            20                  25                  30          
Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr
        35                  40                  45              
Met Ala Glu Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His Pro
    50                  55                  60                  
Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys
65                  70                  75                  80  
Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala
                85                  90                  95      
Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly
            100                 105                 110         
Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu
        115                 120                 125             
Arg Phe Arg Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp
    130                 135                 140                 
Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val
145                 150                 155                 160 
Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala
                165                 170                 175     
Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr
            180                 185                 190         
Val Asn Val Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala
        195                 200                 205             
Tyr Lys Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp
    210                 215                 220                 
Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu
225                 230                 235                 240 
Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met
                245                 250                 255     
Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val
            260                 265                 270         
Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr
        275                 280                 285             
Val Phe Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr
    290                 295                 300                 
Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu
305                 310                 315                 320 
Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser
                325                 330                 335     
Glu Ala Leu Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser
            340                 345                 350         
Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala
        355                 360                 365             
Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr
    370                 375                 380                 
Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile
385                 390                 395                 400 
Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr
                405                 410                 415     
Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr
            420                 425                 430         
Gly Lys Lys Glu Thr Ile Glu Glu Leu Glu Gly Lys Pro Ile Pro Asn
        435                 440                 445             
Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
    450                 455                 460         


<210> 116
<211> 255
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 116
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Lys Asp Ala Lys Leu Val Met Glu Tyr
            20                  25                  30          
Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu
        35                  40                  45              
Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln
    50                  55                  60                  
Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr
65                  70                  75                  80  
Val Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly
                85                  90                  95      
Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe His Val Arg Glu Gly
            100                 105                 110         
Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe
        115                 120                 125             
Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe
    130                 135                 140                 
Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val Ser His Lys
145                 150                 155                 160 
Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp
                165                 170                 175     
Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn
            180                 185                 190         
Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln
        195                 200                 205             
Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala
    210                 215                 220                 
Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe
225                 230                 235                 240 
Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu Leu Glu
                245                 250                 255 


<210> 117
<211> 255
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 117
Met Gly Ser Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys
 1               5                  10                  15      
Asp Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly
            20                  25                  30          
Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp
        35                  40                  45              
Met Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu Val
    50                  55                  60                  
Val Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr
65                  70                  75                  80  
Thr Val Phe Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg
                85                  90                  95      
Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val
            100                 105                 110         
Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu
        115                 120                 125             
Ser Glu Ala Leu Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser
    130                 135                 140                 
Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val
145                 150                 155                 160 
Ala Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His
                165                 170                 175     
Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu
            180                 185                 190         
Ile Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile
        195                 200                 205             
Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu
    210                 215                 220                 
Thr Gly Lys Lys Glu Thr Ile Glu Glu Leu Glu Gly Lys Pro Ile Pro
225                 230                 235                 240 
Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
                245                 250                 255 


<210> 118
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 118
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Gln Gly Lys Leu Pro Phe Ala Ala Ala
            20                  25                  30          
Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu
        35                  40                  45              
Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp
    50                  55                  60                  
Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His
65                  70                  75                  80  
Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg
                85                  90                  95      
Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr
            100                 105                 110         
Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val
        115                 120                 125             
Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu
    130                 135                 140                 
Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser
145                 150                 155                 160 
Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp
                165                 170                 175     
Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu Lys
            180                 185                 190         
Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro Ser
        195                 200                 205             
Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val Met
    210                 215                 220                 
Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met
225                 230                 235                 240 
Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr
                245                 250                 255     
Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe Gln Lys Thr
            260                 265                 270         
Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly
        275                 280                 285             
Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe His Val Arg
    290                 295                 300                 
Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val Ala
305                 310                 315                 320 
Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met
                325                 330                 335     
Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val Ser
            340                 345                 350         
His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg
        355                 360                 365             
Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp Thr
    370                 375                 380                 
Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met
385                 390                 395                 400 
Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln Asp
                405                 410                 415     
Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro
            420                 425                 430         
Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu Leu
        435                 440                 445             
Glu
    


<210> 119
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 119
Met Gly Ser Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn
 1               5                  10                  15      
Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg
            20                  25                  30          
Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp Pro Ser Glu Lys
        35                  40                  45              
Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr Leu Tyr
    50                  55                  60                  
Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met Arg Leu
65                  70                  75                  80  
Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu Gly Tyr
                85                  90                  95      
Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro
            100                 105                 110         
Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu Met Ala His Tyr
        115                 120                 125             
Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile
    130                 135                 140                 
Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His
145                 150                 155                 160 
Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu
                165                 170                 175     
Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro Ser Lys Gly Ala Ile
            180                 185                 190         
Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala
        195                 200                 205             
Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu
    210                 215                 220                 
Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr
225                 230                 235                 240 
Lys Asp Met Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu
                245                 250                 255     
Glu Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile
            260                 265                 270         
Met Tyr Thr Val Phe Glu His Thr Phe His Val Arg Glu Gly Asp Glu
        275                 280                 285             
Gln Arg Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys
    290                 295                 300                 
Ser Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys
305                 310                 315                 320 
Glu Leu Ser Glu Ala Leu Thr Arg His Gly Val Ser His Lys Val Asp
                325                 330                 335     
Asp Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile
            340                 345                 350         
Gly Val Ala Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr
        355                 360                 365             
Pro His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg
    370                 375                 380                 
Ala Glu Ile Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly
385                 390                 395                 400 
Asn Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly
                405                 410                 415     
Gln Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu Leu Glu Gly Lys Pro
            420                 425                 430         
Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His
        435                 440                 445             
His
    


<210> 120
<211> 284
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 120
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Val Ala Glu Lys Pro Leu Lys Glu Pro
            20                  25                  30          
Lys Thr Val Asn Val Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly
        35                  40                  45              
Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile
    50                  55                  60                  
Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys
65                  70                  75                  80  
Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys
                85                  90                  95      
Asp Met Ile Asn Val Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu
            100                 105                 110         
Val Val Pro Asn Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met
        115                 120                 125             
Tyr Thr Val Phe Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln
    130                 135                 140                 
Arg Thr Phe Phe Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser
145                 150                 155                 160 
Val Leu Pro Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu
                165                 170                 175     
Leu Ser Glu Ala Leu Thr Arg His Gly Val Ser His Lys Val Asp Asp
            180                 185                 190         
Ser Ser Gly Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly
        195                 200                 205             
Val Ala Phe Gly Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro
    210                 215                 220                 
His Thr Ala Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala
225                 230                 235                 240 
Glu Ile Ser Glu Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn
                245                 250                 255     
Ile Thr Trp Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln
            260                 265                 270         
Glu Thr Gly Lys Lys Glu Thr Ile Glu Glu Leu Glu
        275                 280                 


<210> 121
<211> 284
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 121
Met Gly Ser Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn
 1               5                  10                  15      
Val Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys
            20                  25                  30          
Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys
        35                  40                  45              
Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr
    50                  55                  60                  
Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn
65                  70                  75                  80  
Val Lys Arg Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn
                85                  90                  95      
Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe
            100                 105                 110         
Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe
        115                 120                 125             
Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu
    130                 135                 140                 
Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala
145                 150                 155                 160 
Leu Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser
                165                 170                 175     
Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly
            180                 185                 190         
Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr
        195                 200                 205             
Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu
    210                 215                 220                 
Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala
225                 230                 235                 240 
Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys
                245                 250                 255     
Lys Glu Thr Ile Glu Glu Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu
            260                 265                 270         
Leu Gly Leu Asp Ser Thr His His His His His His
        275                 280                 


<210> 122
<211> 153
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 122
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Ala Pro Phe Lys Cys Ser Val Leu Pro
            20                  25                  30          
Leu Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu
        35                  40                  45              
Ala Leu Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly
    50                  55                  60                  
Ser Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe
65                  70                  75                  80  
Gly Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala
                85                  90                  95      
Thr Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser
            100                 105                 110         
Glu Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp
        115                 120                 125             
Ala Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly
    130                 135                 140                 
Lys Lys Glu Thr Ile Glu Glu Leu Glu
145                 150             


<210> 123
<211> 153
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 123
Met Gly Ser Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn
 1               5                  10                  15      
Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg
            20                  25                  30          
His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg
        35                  40                  45              
Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile
    50                  55                  60                  
Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp
65                  70                  75                  80  
Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser
                85                  90                  95      
Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu
            100                 105                 110         
Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr
        115                 120                 125             
Ile Glu Glu Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu
    130                 135                 140                 
Asp Ser Thr His His His His His His
145                 150             


<210> 124
<211> 200
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 124
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Arg Lys Val Glu Glu Val Val Pro Asn
            20                  25                  30          
Val Ile Glu Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe
        35                  40                  45              
Glu His Thr Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe
    50                  55                  60                  
Ser Phe Pro Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu
65                  70                  75                  80  
Ser Gln Asn Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala
                85                  90                  95      
Leu Thr Arg His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser
            100                 105                 110         
Ile Gly Arg Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly
        115                 120                 125             
Val Thr Ile Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr
    130                 135                 140                 
Leu Arg Asp Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu
145                 150                 155                 160 
Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala
                165                 170                 175     
Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys
            180                 185                 190         
Lys Glu Thr Ile Glu Glu Leu Glu
        195                 200 


<210> 125
<211> 200
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 125
Met Gly Ser Arg Lys Val Glu Glu Val Val Pro Asn Val Ile Glu Pro
 1               5                  10                  15      
Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr Phe
            20                  25                  30          
His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro Ala
        35                  40                  45              
Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn Gln
    50                  55                  60                  
Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg His
65                  70                  75                  80  
Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg Arg
                85                  90                  95      
Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile Asp
            100                 105                 110         
Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp Arg
        115                 120                 125             
Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile
    130                 135                 140                 
Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala
145                 150                 155                 160 
Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile
                165                 170                 175     
Glu Glu Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
            180                 185                 190         
Ser Thr His His His His His His
        195                 200 


<210> 126
<211> 72
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 126
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Arg Gln Ile Arg Ala Glu Ile Ser Glu
            20                  25                  30          
Leu Pro Ser Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala
        35                  40                  45              
Asp Val Glu Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys
    50                  55                  60                  
Lys Glu Thr Ile Glu Glu Leu Glu
65                  70          


<210> 127
<211> 72
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 127
Met Gly Ser Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser Ile
 1               5                  10                  15      
Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu Ala
            20                  25                  30          
Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr Ile
        35                  40                  45              
Glu Glu Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp
    50                  55                  60                  
Ser Thr His His His His His His
65                  70          


<210> 128
<211> 1323
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 128
ggatccggca ttttcctgaa ctttaaacgt ctgctggaat tcaaccaggg caaactgcct 60
tttgctgccg ctcaaattgg taacagcttc cgtaacgaga ttagcccacg ctctggactg 120
attcgtgtcc gtgagtttac aatggccgaa atcgagcact ttgttgatcc gagcgagaaa 180
gatcacccaa aatttcaaaa cgtggcggac ctgcatctgt atctgtattc agccaaagcc 240
caggtttctg gtcaatcagc tcgtaaaatg cgcctgggag atgctgtaga acagggtgtg 300
attaataaca cggtactggg gtatttcatt ggccgtatct atctgtatct gacgaaagtc 360
ggcattagtc cggataaact gcgctttcgc caacacatgg agaacgaaat ggcccattat 420
gcctgtgact gctgggatgc tgagtctaaa acgtcctatg gatggatcga gatcgtcggt 480
tgtgctgacc gttcatgcta tgacctgtcc tgtcatgccc gtgctaccaa agtccctctg 540
gtggccgaaa aaccgctgaa agagccgaaa accgttaacg tggtacagtt cgaaccgagc 600
aaaggtgcta ttggaaaagc ctataaaaaa gacgccaaac tggtgatgga atatctggcc 660
atctgtgatg agtgctatat caccgagatg gaaatgctgc tgaacgagaa aggtgagttc 720
accatcgaaa ccgaaggcaa aacgtttcaa ctgaccaaag acatgatcaa tgttaaacgc 780
ttccaaaaaa cactgtatgt ggaggaagtt gtcccgaacg ttatcgaacc ttcatttggg 840
ctgggtcgta tcatgtatac ggtgttcgag cacaccttcc atgttcgtga aggcgacgaa 900
cagcgtacct ttttcagctt tccggcagtt gtagcaccat tcaaatgttc cgttctgcca 960
ctgagccaga atcaagagtt catgccgttc gtgaaagaac tgagcgaagc actgactcgt 1020
catggtgtta gccataaagt ggacgatagc agcggctcaa tcggtcgtcg ttatgctcgt 1080
accgatgaga ttggtgtggc gtttggtgta accattgact tcgacacagt gaacaaaacc 1140
cctcataccg ctactctgcg tgatcgtgac tctatgcgtc aaatccgtgc tgagatttct 1200
gagctgccgt ctattgtaca agatctggca aatggtaata tcacatgggc ggacgtggag 1260
gcccgttatc ctctgtttga aggccaagag acaggcaaaa aagaaaccat cgaggagctc 1320
gag                                                               1323

<210> 129
<211> 702
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 129
ggatccaaag acgccaaact ggtgatggaa tatctggcca tctgtgatga gtgctatatc 60
accgagatgg aaatgctgct gaacgagaaa ggtgagttca ccatcgaaac cgaaggcaaa 120
acgtttcaac tgaccaaaga catgatcaat gttaaacgct tccaaaaaac actgtatgtg 180
gaggaagttg tcccgaacgt tatcgaacct tcatttgggc tgggtcgtat catgtatacg 240
gtgttcgagc acaccttcca tgttcgtgaa ggcgacgaac agcgtacctt tttcagcttt 300
ccggcagttg tagcaccatt caaatgttcc gttctgccac tgagccagaa tcaagagttc 360
atgccgttcg tgaaagaact gagcgaagca ctgactcgtc atggtgttag ccataaagtg 420
gacgatagca gcggctcaat cggtcgtcgt tatgctcgta ccgatgagat tggtgtggcg 480
tttggtgtaa ccattgactt cgacacagtg aacaaaaccc ctcataccgc tactctgcgt 540
gatcgtgact ctatgcgtca aatccgtgct gagatttctg agctgccgtc tattgtacaa 600
gatctggcaa atggtaatat cacatgggcg gacgtggagg cccgttatcc tctgtttgaa 660
ggccaagaga caggcaaaaa agaaaccatc gaggagctcg ag                    702

<210> 130
<211> 1284
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 130
ggatcccagg gcaaactgcc ttttgctgcc gctcaaattg gtaacagctt ccgtaacgag 60
attagcccac gctctggact gattcgtgtc cgtgagttta caatggccga aatcgagcac 120
tttgttgatc cgagcgagaa agatcaccca aaatttcaaa acgtggcgga cctgcatctg 180
tatctgtatt cagccaaagc ccaggtttct ggtcaatcag ctcgtaaaat gcgcctggga 240
gatgctgtag aacagggtgt gattaataac acggtactgg ggtatttcat tggccgtatc 300
tatctgtatc tgacgaaagt cggcattagt ccggataaac tgcgctttcg ccaacacatg 360
gagaacgaaa tggcccatta tgcctgtgac tgctgggatg ctgagtctaa aacgtcctat 420
ggatggatcg agatcgtcgg ttgtgctgac cgttcatgct atgacctgtc ctgtcatgcc 480
cgtgctacca aagtccctct ggtggccgaa aaaccgctga aagagccgaa aaccgttaac 540
gtggtacagt tcgaaccgag caaaggtgct attggaaaag cctataaaaa agacgccaaa 600
ctggtgatgg aatatctggc catctgtgat gagtgctata tcaccgagat ggaaatgctg 660
ctgaacgaga aaggtgagtt caccatcgaa accgaaggca aaacgtttca actgaccaaa 720
gacatgatca atgttaaacg cttccaaaaa acactgtatg tggaggaagt tgtcccgaac 780
gttatcgaac cttcatttgg gctgggtcgt atcatgtata cggtgttcga gcacaccttc 840
catgttcgtg aaggcgacga acagcgtacc tttttcagct ttccggcagt tgtagcacca 900
ttcaaatgtt ccgttctgcc actgagccag aatcaagagt tcatgccgtt cgtgaaagaa 960
ctgagcgaag cactgactcg tcatggtgtt agccataaag tggacgatag cagcggctca 1020
atcggtcgtc gttatgctcg taccgatgag attggtgtgg cgtttggtgt aaccattgac 1080
ttcgacacag tgaacaaaac ccctcatacc gctactctgc gtgatcgtga ctctatgcgt 1140
caaatccgtg ctgagatttc tgagctgccg tctattgtac aagatctggc aaatggtaat 1200
atcacatggg cggacgtgga ggcccgttat cctctgtttg aaggccaaga gacaggcaaa 1260
aaagaaacca tcgaggagct cgag                                        1284

<210> 131
<211> 789
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 131
ggatccgtgg ccgaaaaacc gctgaaagag ccgaaaaccg ttaacgtggt acagttcgaa 60
ccgagcaaag gtgctattgg aaaagcctat aaaaaagacg ccaaactggt gatggaatat 120
ctggccatct gtgatgagtg ctatatcacc gagatggaaa tgctgctgaa cgagaaaggt 180
gagttcacca tcgaaaccga aggcaaaacg tttcaactga ccaaagacat gatcaatgtt 240
aaacgcttcc aaaaaacact gtatgtggag gaagttgtcc cgaacgttat cgaaccttca 300
tttgggctgg gtcgtatcat gtatacggtg ttcgagcaca ccttccatgt tcgtgaaggc 360
gacgaacagc gtaccttttt cagctttccg gcagttgtag caccattcaa atgttccgtt 420
ctgccactga gccagaatca agagttcatg ccgttcgtga aagaactgag cgaagcactg 480
actcgtcatg gtgttagcca taaagtggac gatagcagcg gctcaatcgg tcgtcgttat 540
gctcgtaccg atgagattgg tgtggcgttt ggtgtaacca ttgacttcga cacagtgaac 600
aaaacccctc ataccgctac tctgcgtgat cgtgactcta tgcgtcaaat ccgtgctgag 660
atttctgagc tgccgtctat tgtacaagat ctggcaaatg gtaatatcac atgggcggac 720
gtggaggccc gttatcctct gtttgaaggc caagagacag gcaaaaaaga aaccatcgag 780
gagctcgag                                                         789

<210> 132
<211> 396
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 132
ggatccgcac cattcaaatg ttccgttctg ccactgagcc agaatcaaga gttcatgccg 60
ttcgtgaaag aactgagcga agcactgact cgtcatggtg ttagccataa agtggacgat 120
agcagcggct caatcggtcg tcgttatgct cgtaccgatg agattggtgt ggcgtttggt 180
gtaaccattg acttcgacac agtgaacaaa acccctcata ccgctactct gcgtgatcgt 240
gactctatgc gtcaaatccg tgctgagatt tctgagctgc cgtctattgt acaagatctg 300
gcaaatggta atatcacatg ggcggacgtg gaggcccgtt atcctctgtt tgaaggccaa 360
gagacaggca aaaaagaaac catcgaggag ctcgag                           396

<210> 133
<211> 537
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 133
ggatcccgta aagtggagga agttgtcccg aacgttatcg aaccttcatt tgggctgggt 60
cgtatcatgt atacggtgtt cgagcacacc ttccatgttc gtgaaggcga cgaacagcgt 120
acctttttca gctttccggc agttgtagca ccattcaaat gttccgttct gccactgagc 180
cagaatcaag agttcatgcc gttcgtgaaa gaactgagcg aagcactgac tcgtcatggt 240
gttagccata aagtggacga tagcagcggc tcaatcggtc gtcgttatgc tcgtaccgat 300
gagattggtg tggcgtttgg tgtaaccatt gacttcgaca cagtgaacaa aacccctcat 360
accgctactc tgcgtgatcg tgactctatg cgtcaaatcc gtgctgagat ttctgagctg 420
ccgtctattg tacaagatct ggcaaatggt aatatcacat gggcggacgt ggaggcccgt 480
tatcctctgt ttgaaggcca agagacaggc aaaaaagaaa ccatcgagga gctcgag    537

<210> 134
<211> 153
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 134
ggatcccgtc aaatccgtgc tgagatttct gagctgccgt ctattgtaca agatctggca 60
aatggtaata tcacatgggc ggacgtggag gcccgttatc ctctgtttga aggccaagag 120
acaggcaaaa aagaaaccat cgaggagctc gag                              153

<210> 135
<211> 342
<212> PRT
<213> Homo sapiens

<400> 135
Arg Ala Asp His Leu Leu Lys Ala His Leu Gln Lys Leu Met Ser Asp
 1               5                  10                  15      
Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu Ser Val Leu Ala
            20                  25                  30          
Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu Phe Val Asn
        35                  40                  45              
Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu Ser Pro Pro Val
    50                  55                  60                  
Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro Gly Gly Asn Met
65                  70                  75                  80  
Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe
                85                  90                  95      
Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala
            100                 105                 110         
Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu
        115                 120                 125             
Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp
    130                 135                 140                 
Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His
145                 150                 155                 160 
Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg
                165                 170                 175     
Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr
            180                 185                 190         
Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val
        195                 200                 205             
Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu
    210                 215                 220                 
Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser
225                 230                 235                 240 
Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp
                245                 250                 255     
Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu Lys
            260                 265                 270         
Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro Ser
        275                 280                 285             
Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val Met
    290                 295                 300                 
Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met
305                 310                 315                 320 
Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr
                325                 330                 335     
Phe Gln Leu Thr Lys Asp
            340         


<210> 136
<211> 1026
<212> DNA
<213> Homo sapiens

<400> 136
cgtgctgacc atctattaaa agctcattta cagaaattga tgtctgataa gaagtgttct 60
gtcgaaaaga aatcagaaat ggaaagtgtt ttggcccagc ttgataacta tggacagcaa 120
gaacttgcgg atctttttgt gaactataat gtaaaatctc ccattactgg aaatgatcta 180
tcccctccag tgtcttttaa cttaatgttc aagactttca ttgggcctgg aggaaacatg 240
cctgggtact tgagaccaga aactgcacag gggattttct tgaatttcaa acgacttttg 300
gagttcaacc aaggaaagtt gccttttgct gctgcccaga ttggaaattc ttttagaaat 360
gagatctccc ctcgatctgg actgatcaga gtcagagaat tcacaatggc agaaattgag 420
cactttgtag atcccagtga gaaagaccac cccaagttcc agaatgtggc agaccttcac 480
ctttatttgt attcagcaaa agcccaggtc agcggacagt ccgctcggaa aatgcgcctg 540
ggagatgctg ttgaacaggg tgtgattaat aacacagtat taggctattt cattggccgc 600
atctacctct acctcacgaa ggttggaata tctccagata aactccgctt ccggcagcac 660
atggagaatg agatggccca ttatgcctgt gactgttggg atgcagaatc caaaacatcc 720
tacggttgga ttgagattgt tggatgtgct gatcgttcct gttatgacct ctcctgtcat 780
gcacgagcca ccaaagtccc acttgtagct gagaaacctc tgaaagaacc caaaacagtc 840
aatgttgttc agtttgaacc cagtaaggga gcaattggta aggcatataa gaaggatgca 900
aaactggtga tggagtatct tgccatttgt gatgagtgct acattacaga aatggagatg 960
ctgctgaatg agaaagggga attcacaatt gaaactgaag ggaaaacatt tcagttaaca 1020
aaagac                                                            1026

<210> 137
<211> 471
<212> PRT
<213> Homo sapiens

<400> 137
Val Asp Lys Ala Val Ala Glu Leu Lys Ala Arg Lys Arg Val Leu Glu
 1               5                  10                  15      
Ala Lys Glu Leu Ala Leu Gln Pro Lys Asp Asp Ile Val Asp Arg Ala
            20                  25                  30          
Lys Met Glu Asp Thr Leu Lys Arg Arg Phe Phe Tyr Asp Gln Ala Phe
        35                  40                  45              
Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly
    50                  55                  60                  
Cys Ala Leu Lys Asn Asn Ile Ile Gln Thr Trp Arg Gln His Phe Ile
65                  70                  75                  80  
Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys Thr Met Leu Thr Pro Glu
                85                  90                  95      
Pro Val Leu Lys Thr Ser Gly His Val Asp Lys Phe Ala Asp Phe Met
            100                 105                 110         
Val Lys Asp Val Lys Asn Gly Glu Cys Phe Arg Ala Asp His Leu Leu
        115                 120                 125             
Lys Ala His Leu Gln Lys Leu Met Ser Asp Lys Lys Cys Ser Val Glu
    130                 135                 140                 
Lys Lys Ser Glu Met Glu Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly
145                 150                 155                 160 
Gln Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr Asn Val Lys Ser Pro
                165                 170                 175     
Ile Thr Gly Asn Asp Leu Ser Pro Pro Val Ser Phe Asn Leu Met Phe
            180                 185                 190         
Lys Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro
        195                 200                 205             
Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe
    210                 215                 220                 
Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe
225                 230                 235                 240 
Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe
                245                 250                 255     
Thr Met Ala Glu Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His
            260                 265                 270         
Pro Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala
        275                 280                 285             
Lys Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp
    290                 295                 300                 
Ala Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile
305                 310                 315                 320 
Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys
                325                 330                 335     
Leu Arg Phe Arg Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys
            340                 345                 350         
Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile
        355                 360                 365             
Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg
    370                 375                 380                 
Ala Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys
385                 390                 395                 400 
Thr Val Asn Val Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys
                405                 410                 415     
Ala Tyr Lys Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys
            420                 425                 430         
Asp Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly
        435                 440                 445             
Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp
    450                 455                 460                 
Met Ile Asn Val Lys Arg Phe
465                 470     


<210> 138
<211> 1413
<212> DNA
<213> Homo sapiens

<400> 138
gtagacaaag cagtggctga gctcaaagcc cgcaagaggg ttctggaagc aaaggagctg 60
gcgttacagc ccaaagatga tattgtagac cgagcaaaaa tggaagatac cctgaagagg 120
aggtttttct atgatcaagc ttttgctatt tatggaggtg ttagtggtct gtatgacttt 180
gggccagttg gctgtgcttt gaagaacaat attattcaga cctggaggca gcactttatc 240
caagaggaac agatcctgga gatcgattgc accatgctca cccctgagcc agttttaaag 300
acctctggcc atgtagacaa atttgctgac ttcatggtga aagacgtaaa aaatggagaa 360
tgttttcgtg ctgaccatct attaaaagct catttacaga aattgatgtc tgataagaag 420
tgttctgtcg aaaagaaatc agaaatggaa agtgttttgg cccagcttga taactatgga 480
cagcaagaac ttgcggatct ttttgtgaac tataatgtaa aatctcccat tactggaaat 540
gatctatccc ctccagtgtc ttttaactta atgttcaaga ctttcattgg gcctggagga 600
aacatgcctg ggtacttgag accagaaact gcacagggga ttttcttgaa tttcaaacga 660
cttttggagt tcaaccaagg aaagttgcct tttgctgctg cccagattgg aaattctttt 720
agaaatgaga tctcccctcg atctggactg atcagagtca gagaattcac aatggcagaa 780
attgagcact ttgtagatcc cagtgagaaa gaccacccca agttccagaa tgtggcagac 840
cttcaccttt atttgtattc agcaaaagcc caggtcagcg gacagtccgc tcggaaaatg 900
cgcctgggag atgctgttga acagggtgtg attaataaca cagtattagg ctatttcatt 960
ggccgcatct acctctacct cacgaaggtt ggaatatctc cagataaact ccgcttccgg 1020
cagcacatgg agaatgagat ggcccattat gcctgtgact gttgggatgc agaatccaaa 1080
acatcctacg gttggattga gattgttgga tgtgctgatc gttcctgtta tgacctctcc 1140
tgtcatgcac gagccaccaa agtcccactt gtagctgaga aacctctgaa agaacccaaa 1200
acagtcaatg ttgttcagtt tgaacccagt aagggagcaa ttggtaaggc atataagaag 1260
gatgcaaaac tggtgatgga gtatcttgcc atttgtgatg agtgctacat tacagaaatg 1320
gagatgctgc tgaatgagaa aggggaattc acaattgaaa ctgaagggaa aacatttcag 1380
ttaacaaaag acatgatcaa tgtgaagaga ttc                              1413

<210> 139
<211> 29
<212> PRT
<213> Mus musculus

<400> 139
Lys Ser Glu Met Glu Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln
 1               5                  10                  15      
Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr Asn Val Lys
            20                  25                  


<210> 140
<211> 127
<212> PRT
<213> Mus musculus

<400> 140
Ser Pro Thr Thr Gly Asn Asp Leu Ser Pro Pro Val Pro Phe Asn Leu
 1               5                  10                  15      
Met Phe Gln Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu
            20                  25                  30          
Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu
        35                  40                  45              
Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn
    50                  55                  60                  
Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg
65                  70                  75                  80  
Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp Pro Thr Glu Lys
                85                  90                  95      
Asp His Pro Lys Phe Gln Ser Val Ala Asp Leu Cys Leu Tyr Leu Tyr
            100                 105                 110         
Ser Ala Lys Ala Gln Val Thr Gly Gln Ser Ala Arg Lys Met Arg
        115                 120                 125         


<210> 141
<211> 21
<212> PRT
<213> Mus musculus

<400> 141
Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Ser Val Leu Gly
 1               5                  10                  15      
Tyr Phe Ile Gly Arg
            20      


<210> 142
<211> 78
<212> PRT
<213> Mus musculus

<400> 142
Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg
 1               5                  10                  15      
Phe Arg Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys
            20                  25                  30          
Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly
        35                  40                  45              
Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr
    50                  55                  60                  
Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys
65                  70                  75              


<210> 143
<211> 11
<212> PRT
<213> Mus musculus

<400> 143
Thr Val Asn Val Val Gln Phe Glu Pro Asn Lys
 1               5                  10      


<210> 144
<211> 266
<212> PRT
<213> Mus musculus

<400> 144
Lys Ser Glu Met Glu Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln
 1               5                  10                  15      
Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr Asn Val Lys Ser Pro Thr
            20                  25                  30          
Thr Gly Asn Asp Leu Ser Pro Pro Val Pro Phe Asn Leu Met Phe Gln
        35                  40                  45              
Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu
    50                  55                  60                  
Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn
65                  70                  75                  80  
Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg
                85                  90                  95      
Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr
            100                 105                 110         
Met Ala Glu Ile Glu His Phe Val Asp Pro Thr Glu Lys Asp His Pro
        115                 120                 125             
Lys Phe Gln Ser Val Ala Asp Leu Cys Leu Tyr Leu Tyr Ser Ala Lys
    130                 135                 140                 
Ala Gln Val Thr Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala
145                 150                 155                 160 
Val Glu Gln Gly Val Ile Asn Asn Ser Val Leu Gly Tyr Phe Ile Gly
                165                 170                 175     
Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu
            180                 185                 190         
Arg Phe Arg Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp
        195                 200                 205             
Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val
    210                 215                 220                 
Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala
225                 230                 235                 240 
Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr
                245                 250                 255     
Val Asn Val Val Gln Phe Glu Pro Asn Lys
            260                 265     


<210> 145
<211> 13
<212> PRT
<213> Mus musculus

<400> 145
Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg
 1               5                  10              


<210> 146
<211> 60
<212> PRT
<213> Mus musculus

<400> 146
Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr
 1               5                  10                  15      
Met Ala Glu Ile Glu His Phe Val Asp Pro Thr Glu Lys Asp His Pro
            20                  25                  30          
Lys Phe Gln Ser Val Ala Asp Leu Cys Leu Tyr Leu Tyr Ser Ala Lys
        35                  40                  45              
Ala Gln Val Thr Gly Gln Ser Ala Arg Lys Met Arg
    50                  55                  60  


<210> 147
<211> 21
<212> PRT
<213> Mus musculus

<400> 147
Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Ser Val Leu Gly
 1               5                  10                  15      
Tyr Phe Ile Gly Arg
            20      


<210> 148
<211> 78
<212> PRT
<213> Mus musculus

<400> 148
Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg
 1               5                  10                  15      
Phe Arg Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys
            20                  25                  30          
Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly
        35                  40                  45              
Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr
    50                  55                  60                  
Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys
65                  70                  75              


<210> 149
<211> 16
<212> PRT
<213> Mus musculus

<400> 149
Thr Val Asn Val Val Gln Phe Glu Pro Asn Lys Gly Ala Val Gly Lys
 1               5                  10                  15      


<210> 150
<211> 188
<212> PRT
<213> Mus musculus

<400> 150
Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile
 1               5                  10                  15      
Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu
            20                  25                  30          
Ile Glu His Phe Val Asp Pro Thr Glu Lys Asp His Pro Lys Phe Gln
        35                  40                  45              
Ser Val Ala Asp Leu Cys Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val
    50                  55                  60                  
Thr Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln
65                  70                  75                  80  
Gly Val Ile Asn Asn Ser Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr
                85                  90                  95      
Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg
            100                 105                 110         
Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp
        115                 120                 125             
Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala
    130                 135                 140                 
Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val
145                 150                 155                 160 
Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val
                165                 170                 175     
Val Gln Phe Glu Pro Asn Lys Gly Ala Val Gly Lys
            180                 185             


<210> 151
<211> 65
<212> PRT
<213> Homo sapiens

<400> 151
Gly Ala Gly Ala Glu Glu Val Leu Ala Pro Leu Arg Leu Ala Val Arg
 1               5                  10                  15      
Gln Gln Gly Asp Leu Val Arg Lys Leu Lys Glu Asp Lys Ala Pro Gln
            20                  25                  30          
Val Asp Val Asp Lys Ala Val Ala Glu Leu Lys Ala Arg Lys Arg Val
        35                  40                  45              
Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys Asp Asp Ile Val Asp
    50                  55                  60                  
Arg
65  


<210> 152
<211> 195
<212> DNA
<213> Homo sapiens

<400> 152
ggcgcggggg ctgaggaggt gctggcacct ctgaggctag cagtgcgcca gcagggagat 60
cttgtgcgaa aactcaaaga agataaagca ccccaagtag acgtagacaa agcagtggct 120
gagctcaaag cccgcaagag ggttctggaa gcaaaggagc tggcgttaca gcccaaagat 180
gatattgtag accga                                                  195

<210> 153
<211> 43
<212> PRT
<213> Homo sapiens

<400> 153
Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly
 1               5                  10                  15      
Cys Ala Leu Lys Asn Asn Ile Ile Gln Thr Trp Arg Gln His Phe Ile
            20                  25                  30          
Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys Thr
        35                  40              


<210> 154
<211> 129
<212> DNA
<213> Homo sapiens

<400> 154
gctatttatg gaggtgttag tggtctgtat gactttgggc cagttggctg tgctttgaag 60
aacaatatta ttcagacctg gaggcagcac tttatccaag aggaacagat cctggagatc 120
gattgcacc                                                         129

<210> 155
<211> 225
<212> PRT
<213> Homo sapiens

<400> 155
Thr Gly Asn Asp Leu Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys
 1               5                  10                  15      
Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu
            20                  25                  30          
Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn
        35                  40                  45              
Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg
    50                  55                  60                  
Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr
65                  70                  75                  80  
Met Ala Glu Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His Pro
                85                  90                  95      
Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys
            100                 105                 110         
Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala
        115                 120                 125             
Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly
    130                 135                 140                 
Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu
145                 150                 155                 160 
Arg Phe Arg Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp
                165                 170                 175     
Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val
            180                 185                 190         
Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala
        195                 200                 205             
Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr
    210                 215                 220                 
Val
225 


<210> 156
<211> 675
<212> DNA
<213> Homo sapiens

<400> 156
actggaaatg atctatcccc tccagtgtct tttaacttaa tgttcaagac tttcattggg 60
cctggaggaa acatgcctgg gtacttgaga ccagaaactg cacaggggat tttcttgaat 120
ttcaaacgac ttttggagtt caaccaagga aagttgcctt ttgctgctgc ccagattgga 180
aattctttta gaaatgagat ctcccctcga tctggactga tcagagtcag agaattcaca 240
atggcagaaa ttgagcactt tgtagatccc agtgagaaag accaccccaa gttccagaat 300
gtggcagacc ttcaccttta tttgtattca gcaaaagccc aggtcagcgg acagtccgct 360
cggaaaatgc gcctgggaga tgctgttgaa cagggtgtga ttaataacac agtattaggc 420
tatttcattg gccgcatcta cctctacctc acgaaggttg gaatatctcc agataaactc 480
cgcttccggc agcacatgga gaatgagatg gcccattatg cctgtgactg ttgggatgca 540
gaatccaaaa catcctacgg ttggattgag attgttggat gtgctgatcg ttcctgttat 600
gacctctcct gtcatgcacg agccaccaaa gtcccacttg tagctgagaa acctctgaaa 660
gaacccaaaa cagtc                                                  675

<210> 157
<211> 130
<212> PRT
<213> Homo sapiens

<400> 157
Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly
 1               5                  10                  15      
Cys Ala Leu Lys Asn Asn Ile Ile Gln Thr Trp Arg Gln His Phe Ile
            20                  25                  30          
Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys Thr Met Leu Thr Pro Glu
        35                  40                  45              
Pro Val Leu Lys Thr Ser Gly His Val Asp Lys Phe Ala Asp Phe Met
    50                  55                  60                  
Val Lys Asp Val Lys Asn Gly Glu Cys Phe Arg Ala Asp His Leu Leu
65                  70                  75                  80  
Lys Ala His Leu Gln Lys Leu Met Ser Asp Lys Lys Cys Ser Val Glu
                85                  90                  95      
Lys Lys Ser Glu Met Glu Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly
            100                 105                 110         
Gln Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr Asn Val Lys Ser Pro
        115                 120                 125             
Ile Thr
    130 


<210> 158
<211> 390
<212> DNA
<213> Homo sapiens

<400> 158
gctatttatg gaggtgttag tggtctgtat gactttgggc cagttggctg tgctttgaag 60
aacaatatta ttcagacctg gaggcagcac tttatccaag aggaacagat cctggagatc 120
gattgcacca tgctcacccc tgagccagtt ttaaagacct ctggccatgt agacaaattt 180
gctgacttca tggtgaaaga cgtaaaaaat ggagaatgtt ttcgtgctga ccatctatta 240
aaagctcatt tacagaaatt gatgtctgat aagaagtgtt ctgtcgaaaa gaaatcagaa 300
atggaaagtg ttttggccca gcttgataac tatggacagc aagaacttgc ggatcttttt 360
gtgaactata atgtaaaatc tcccattact                                  390

<210> 159
<211> 125
<212> PRT
<213> Homo sapiens

<400> 159
Thr Gly Asn Asp Leu Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys
 1               5                  10                  15      
Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu
            20                  25                  30          
Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn
        35                  40                  45              
Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg
    50                  55                  60                  
Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr
65                  70                  75                  80  
Met Ala Glu Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His Pro
                85                  90                  95      
Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys
            100                 105                 110         
Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met Arg Leu
        115                 120                 125 


<210> 160
<211> 375
<212> DNA
<213> Homo sapiens

<400> 160
actggaaatg atctatcccc tccagtgtct tttaacttaa tgttcaagac tttcattggg 60
cctggaggaa acatgcctgg gtacttgaga ccagaaactg cacaggggat tttcttgaat 120
ttcaaacgac ttttggagtt caaccaagga aagttgcctt ttgctgctgc ccagattgga 180
aattctttta gaaatgagat ctcccctcga tctggactga tcagagtcag agaattcaca 240
atggcagaaa ttgagcactt tgtagatccc agtgagaaag accaccccaa gttccagaat 300
gtggcagacc ttcaccttta tttgtattca gcaaaagccc aggtcagcgg acagtccgct 360
cggaaaatgc gcctg                                                  375

<210> 161
<211> 94
<212> PRT
<213> Homo sapiens

<400> 161
Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr
 1               5                  10                  15      
Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg
            20                  25                  30          
Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp
        35                  40                  45              
Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala
    50                  55                  60                  
Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val
65                  70                  75                  80  
Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val
                85                  90                  


<210> 162
<211> 282
<212> DNA
<213> Homo sapiens

<400> 162
ggtgtgatta ataacacagt attaggctat ttcattggcc gcatctacct ctacctcacg 60
aaggttggaa tatctccaga taaactccgc ttccggcagc acatggagaa tgagatggcc 120
cattatgcct gtgactgttg ggatgcagaa tccaaaacat cctacggttg gattgagatt 180
gttggatgtg ctgatcgttc ctgttatgac ctctcctgtc atgcacgagc caccaaagtc 240
ccacttgtag ctgagaaacc tctgaaagaa cccaaaacag tc                    282

<210> 163
<211> 70
<212> PRT
<213> Homo sapiens

<400> 163
Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr
 1               5                  10                  15      
Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg
            20                  25                  30          
Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp
        35                  40                  45              
Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala
    50                  55                  60                  
Asp Arg Ser Cys Tyr Asp
65                  70  


<210> 164
<211> 210
<212> DNA
<213> Homo sapiens

<400> 164
ggtgtgatta ataacacagt attaggctat ttcattggcc gcatctacct ctacctcacg 60
aaggttggaa tatctccaga taaactccgc ttccggcagc acatggagaa tgagatggcc 120
cattatgcct gtgactgttg ggatgcagaa tccaaaacat cctacggttg gattgagatt 180
gttggatgtg ctgatcgttc ctgttatgac                                  210

<210> 165
<211> 72
<212> PRT
<213> Homo sapiens

<400> 165
Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu
 1               5                  10                  15      
Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser
            20                  25                  30          
Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp
        35                  40                  45              
Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu Lys
    50                  55                  60                  
Pro Leu Lys Glu Pro Lys Thr Val
65                  70          


<210> 166
<211> 216
<212> DNA
<213> Homo sapiens

<400> 166
ggaatatctc cagataaact ccgcttccgg cagcacatgg agaatgagat ggcccattat 60
gcctgtgact gttgggatgc agaatccaaa acatcctacg gttggattga gattgttgga 120
tgtgctgatc gttcctgtta tgacctctcc tgtcatgcac gagccaccaa agtcccactt 180
gtagctgaga aacctctgaa agaacccaaa acagtc                           216

<210> 167
<211> 132
<212> PRT
<213> Homo sapiens

<400> 167
Thr Gly Asn Asp Leu Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys
 1               5                  10                  15      
Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu
            20                  25                  30          
Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn
        35                  40                  45              
Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg
    50                  55                  60                  
Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr
65                  70                  75                  80  
Met Ala Glu Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His Pro
                85                  90                  95      
Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys
            100                 105                 110         
Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala
        115                 120                 125             
Val Glu Gln Gly
    130         


<210> 168
<211> 396
<212> DNA
<213> Homo sapiens

<400> 168
actggaaatg atctatcccc tccagtgtct tttaacttaa tgttcaagac tttcattggg 60
cctggaggaa acatgcctgg gtacttgaga ccagaaactg cacaggggat tttcttgaat 120
ttcaaacgac ttttggagtt caaccaagga aagttgcctt ttgctgctgc ccagattgga 180
aattctttta gaaatgagat ctcccctcga tctggactga tcagagtcag agaattcaca 240
atggcagaaa ttgagcactt tgtagatccc agtgagaaag accaccccaa gttccagaat 300
gtggcagacc ttcaccttta tttgtattca gcaaaagccc aggtcagcgg acagtccgct 360
cggaaaatgc gcctgggaga tgctgttgaa cagggt                           396

<210> 169
<211> 367
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 169
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Arg Ala Asp His Leu Leu Lys Ala His
            20                  25                  30          
Leu Gln Lys Leu Met Ser Asp Lys Lys Cys Ser Val Glu Lys Lys Ser
        35                  40                  45              
Glu Met Glu Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu
    50                  55                  60                  
Leu Ala Asp Leu Phe Val Asn Tyr Asn Val Lys Ser Pro Ile Thr Gly
65                  70                  75                  80  
Asn Asp Leu Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys Thr Phe
                85                  90                  95      
Ile Gly Pro Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala
            100                 105                 110         
Gln Gly Ile Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly
        115                 120                 125             
Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu
    130                 135                 140                 
Ile Ser Pro Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala
145                 150                 155                 160 
Glu Ile Glu His Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe
                165                 170                 175     
Gln Asn Val Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln
            180                 185                 190         
Val Ser Gly Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu
        195                 200                 205             
Gln Gly Val Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile
    210                 215                 220                 
Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe
225                 230                 235                 240 
Arg Gln His Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp
                245                 250                 255     
Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys
            260                 265                 270         
Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys
        275                 280                 285             
Val Pro Leu Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn
    290                 295                 300                 
Val Val Gln Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys
305                 310                 315                 320 
Lys Asp Ala Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys
                325                 330                 335     
Tyr Ile Thr Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr
            340                 345                 350         
Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Leu Glu
        355                 360                 365         


<210> 170
<211> 367
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 170
Met Gly Ser Arg Ala Asp His Leu Leu Lys Ala His Leu Gln Lys Leu
 1               5                  10                  15      
Met Ser Asp Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu Ser
            20                  25                  30          
Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu
        35                  40                  45              
Phe Val Asn Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu Ser
    50                  55                  60                  
Pro Pro Val Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro Gly
65                  70                  75                  80  
Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe
                85                  90                  95      
Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe
            100                 105                 110         
Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg
        115                 120                 125             
Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu His
    130                 135                 140                 
Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala
145                 150                 155                 160 
Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln
                165                 170                 175     
Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile
            180                 185                 190         
Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu
        195                 200                 205             
Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met
    210                 215                 220                 
Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser
225                 230                 235                 240 
Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser
                245                 250                 255     
Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu Val
            260                 265                 270         
Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe
        275                 280                 285             
Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys
    290                 295                 300                 
Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu
305                 310                 315                 320 
Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu
                325                 330                 335     
Gly Lys Thr Phe Gln Leu Thr Lys Asp Leu Glu Gly Lys Pro Ile Pro
            340                 345                 350         
Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
        355                 360                 365         


<210> 171
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 171
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Val Asp Lys Ala Val Ala Glu Leu Lys
            20                  25                  30          
Ala Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys
        35                  40                  45              
Asp Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu Lys Arg Arg
    50                  55                  60                  
Phe Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val Ser Gly Leu
65                  70                  75                  80  
Tyr Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn Ile Ile Gln
                85                  90                  95      
Thr Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu Glu Ile Asp
            100                 105                 110         
Cys Thr Met Leu Thr Pro Glu Pro Val Leu Lys Thr Ser Gly His Val
        115                 120                 125             
Asp Lys Phe Ala Asp Phe Met Val Lys Asp Val Lys Asn Gly Glu Cys
    130                 135                 140                 
Phe Arg Ala Asp His Leu Leu Lys Ala His Leu Gln Lys Leu Met Ser
145                 150                 155                 160 
Asp Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu Ser Val Leu
                165                 170                 175     
Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu Phe Val
            180                 185                 190         
Asn Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu Ser Pro Pro
        195                 200                 205             
Val Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro Gly Gly Asn
    210                 215                 220                 
Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn
225                 230                 235                 240 
Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala
                245                 250                 255     
Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly
            260                 265                 270         
Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val
        275                 280                 285             
Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu
    290                 295                 300                 
His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala
305                 310                 315                 320 
Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn
                325                 330                 335     
Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys
            340                 345                 350         
Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn
        355                 360                 365             
Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr
    370                 375                 380                 
Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr
385                 390                 395                 400 
Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu
                405                 410                 415     
Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro
            420                 425                 430         
Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val
        435                 440                 445             
Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu
    450                 455                 460                 
Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys
465                 470                 475                 480 
Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg Phe Leu Glu
                485                 490                 495     


<210> 172
<211> 496
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 172
Met Gly Ser Val Asp Lys Ala Val Ala Glu Leu Lys Ala Arg Lys Arg
 1               5                  10                  15      
Val Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys Asp Asp Ile Val
            20                  25                  30          
Asp Arg Ala Lys Met Glu Asp Thr Leu Lys Arg Arg Phe Phe Tyr Asp
        35                  40                  45              
Gln Ala Phe Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr Asp Phe Gly
    50                  55                  60                  
Pro Val Gly Cys Ala Leu Lys Asn Asn Ile Ile Gln Thr Trp Arg Gln
65                  70                  75                  80  
His Phe Ile Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys Thr Met Leu
                85                  90                  95      
Thr Pro Glu Pro Val Leu Lys Thr Ser Gly His Val Asp Lys Phe Ala
            100                 105                 110         
Asp Phe Met Val Lys Asp Val Lys Asn Gly Glu Cys Phe Arg Ala Asp
        115                 120                 125             
His Leu Leu Lys Ala His Leu Gln Lys Leu Met Ser Asp Lys Lys Cys
    130                 135                 140                 
Ser Val Glu Lys Lys Ser Glu Met Glu Ser Val Leu Ala Gln Leu Asp
145                 150                 155                 160 
Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu Phe Val Asn Tyr Asn Val
                165                 170                 175     
Lys Ser Pro Ile Thr Gly Asn Asp Leu Ser Pro Pro Val Ser Phe Asn
            180                 185                 190         
Leu Met Phe Lys Thr Phe Ile Gly Pro Gly Gly Asn Met Pro Gly Tyr
        195                 200                 205             
Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe Lys Arg Leu
    210                 215                 220                 
Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala Gln Ile Gly
225                 230                 235                 240 
Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu Ile Arg Val
                245                 250                 255     
Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp Pro Ser Glu
            260                 265                 270         
Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His Leu Tyr Leu
        275                 280                 285             
Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg Lys Met Arg
    290                 295                 300                 
Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr Val Leu Gly
305                 310                 315                 320 
Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val Gly Ile Ser
                325                 330                 335     
Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu Met Ala His
            340                 345                 350         
Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser Tyr Gly Trp
        355                 360                 365             
Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp Leu Ser Cys
    370                 375                 380                 
His Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu Lys Pro Leu Lys
385                 390                 395                 400 
Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro Ser Lys Gly Ala
                405                 410                 415     
Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val Met Glu Tyr Leu
            420                 425                 430         
Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met Leu Leu Asn
        435                 440                 445             
Glu Lys Gly Glu Phe Thr Ile Glu Thr Glu Gly Lys Thr Phe Gln Leu
    450                 455                 460                 
Thr Lys Asp Met Ile Asn Val Lys Arg Phe Leu Glu Gly Lys Pro Ile
465                 470                 475                 480 
Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His
                485                 490                 495     


<210> 173
<211> 90
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 173
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Gly Ala Gly Ala Glu Glu Val Leu Ala
            20                  25                  30          
Pro Leu Arg Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys Leu
        35                  40                  45              
Lys Glu Asp Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala Glu
    50                  55                  60                  
Leu Lys Ala Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu Gln
65                  70                  75                  80  
Pro Lys Asp Asp Ile Val Asp Arg Leu Glu
                85                  90  


<210> 174
<211> 90
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 174
Met Gly Ser Gly Ala Gly Ala Glu Glu Val Leu Ala Pro Leu Arg Leu
 1               5                  10                  15      
Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys Leu Lys Glu Asp Lys
            20                  25                  30          
Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala Glu Leu Lys Ala Arg
        35                  40                  45              
Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys Asp Asp
    50                  55                  60                  
Ile Val Asp Arg Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly
65                  70                  75                  80  
Leu Asp Ser Thr His His His His His His
                85                  90  


<210> 175
<211> 1038
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 175
ggatcccgtg ccgatcacct gctgaaagca catctgcaaa aactgatgag cgacaaaaaa 60
tgttccgtgg aaaaaaaatc cgagatggag agcgtactgg cacagctgga taattatggg 120
cagcaagaac tggccgacct gtttgtgaac tataacgtga aaagtcctat caccgggaat 180
gatctgagtc cgcctgtctc ctttaacctg atgttcaaaa cgttcattgg ccctggtggt 240
aatatgccgg gttatctgcg cccagaaaca gcccagggaa ttttcctgaa cttcaaacgt 300
ctgctggagt ttaatcaggg caaactgccg ttcgctgctg ctcaaatcgg taacagcttc 360
cgtaacgaga ttagccctcg tagtggactg atccgtgttc gtgaattcac tatggccgag 420
atcgagcatt tcgttgatcc gagcgagaaa gaccatccaa aatttcaaaa tgtggccgat 480
ctgcatctgt atctgtattc ggcgaaagct caggtgtctg gacagagtgc tcgtaaaatg 540
cgtctgggtg acgctgtaga acaaggcgtg atcaataata ccgtcctggg atatttcatt 600
ggccgtatct atctgtatct gaccaaagtg ggcattagtc ctgacaaact gcgttttcgt 660
caacacatgg agaatgagat ggcccattat gcctgtgatt gctgggacgc tgaatcaaaa 720
acctcctatg gctggattga gattgtgggg tgtgctgatc gttcatgcta tgacctgtcg 780
tgtcatgccc gtgctaccaa agttcctctg gttgccgaga aacctctgaa agagcctaaa 840
accgtaaacg tggtccaatt cgaaccgtcg aaaggggcga ttgggaaagc ctataaaaaa 900
gatgctaaac tggtgatgga gtatctggca atctgtgatg agtgctatat cacggagatg 960
gagatgctgc tgaacgaaaa aggcgagttc acgatcgaaa ccgaaggcaa aactttccaa 1020
ctgactaaag acctcgag                                               1038

<210> 176
<211> 1425
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 176
ggatccgtgg ataaagccgt tgccgaactg aaagcccgta aacgtgttct ggaagcgaaa 60
gagctggccc tgcagccaaa agatgatatc gtcgaccgtg ctaaaatgga ggacaccctg 120
aaacgtcgtt ttttctatga ccaggccttt gccatctatg gtggtgttag cggtctgtat 180
gatttcggtc cggttggttg tgctctgaaa aacaacatca tccaaacgtg gcgtcagcat 240
ttcatccagg aggagcagat tctggagatt gactgtacca tgctgacacc ggaacctgtg 300
ctgaaaacca gcggtcatgt ggacaaattt gccgacttca tggtgaaaga cgtcaaaaat 360
ggcgagtgtt tccgtgccga tcacctgctg aaagcacatc tgcaaaaact gatgagcgac 420
aaaaaatgtt ccgtggaaaa aaaatccgag atggagagcg tactggcaca gctggataat 480
tatgggcagc aagaactggc cgacctgttt gtgaactata acgtgaaaag tcctatcacc 540
gggaatgatc tgagtccgcc tgtctccttt aacctgatgt tcaaaacgtt cattggccct 600
ggtggtaata tgccgggtta tctgcgccca gaaacagccc agggaatttt cctgaacttc 660
aaacgtctgc tggagtttaa tcagggcaaa ctgccgttcg ctgctgctca aatcggtaac 720
agcttccgta acgagattag ccctcgtagt ggactgatcc gtgttcgtga attcactatg 780
gccgagatcg agcatttcgt tgatccgagc gagaaagacc atccaaaatt tcaaaatgtg 840
gccgatctgc atctgtatct gtattcggcg aaagctcagg tgtctggaca gagtgctcgt 900
aaaatgcgtc tgggtgacgc tgtagaacaa ggcgtgatca ataataccgt cctgggatat 960
ttcattggcc gtatctatct gtatctgacc aaagtgggca ttagtcctga caaactgcgt 1020
tttcgtcaac acatggagaa tgagatggcc cattatgcct gtgattgctg ggacgctgaa 1080
tcaaaaacct cctatggctg gattgagatt gtggggtgtg ctgatcgttc atgctatgac 1140
ctgtcgtgtc atgcccgtgc taccaaagtt cctctggttg ccgagaaacc tctgaaagag 1200
cctaaaaccg taaacgtggt ccaattcgaa ccgtcgaaag gggcgattgg gaaagcctat 1260
aaaaaagatg ctaaactggt gatggagtat ctggcaatct gtgatgagtg ctatatcacg 1320
gagatggaga tgctgctgaa cgaaaaaggc gagttcacga tcgaaaccga aggcaaaact 1380
ttccaactga ctaaagacat gatcaatgtg aaacgcttcc tcgag                 1425

<210> 177
<211> 207
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 177
ggatccggtg ccggagctga agaagtcctg gcccctctgc gtctggctgt tcgtcaacaa 60
ggtgatctgg tccgtaaact gaaagaggac aaagcacctc aggttgatgt cgataaagcg 120
gtggcggaac tgaaagcccg taaacgtgtt ctggaagcga aagagctggc cctgcaacca 180
aaagatgata tcgtggaccg cctcgag                                     207

<210> 178
<211> 516
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 178
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Asp Gly Ala Gly Ala Glu Glu Val Leu
            20                  25                  30          
Ala Pro Leu Arg Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys
        35                  40                  45              
Leu Lys Glu Asp Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala
    50                  55                  60                  
Glu Leu Lys Ala Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu
65                  70                  75                  80  
Gln Pro Lys Asp Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu
                85                  90                  95      
Lys Arg Arg Phe Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val
            100                 105                 110         
Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn
        115                 120                 125             
Ile Ile Gln Thr Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu
    130                 135                 140                 
Glu Ile Asp Cys Thr Met Leu Thr Pro Glu Pro Val Leu Lys Thr Ser
145                 150                 155                 160 
Gly His Val Asp Lys Phe Ala Asp Phe Met Val Lys Asp Val Lys Asn
                165                 170                 175     
Gly Glu Cys Phe Arg Ala Asp His Leu Leu Lys Ala His Leu Gln Lys
            180                 185                 190         
Leu Met Ser Asp Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu
        195                 200                 205             
Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp
    210                 215                 220                 
Leu Phe Val Asn Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu
225                 230                 235                 240 
Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro
                245                 250                 255     
Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile
            260                 265                 270         
Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro
        275                 280                 285             
Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro
    290                 295                 300                 
Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu
305                 310                 315                 320 
His Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val
                325                 330                 335     
Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly
            340                 345                 350         
Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val
        355                 360                 365             
Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr
    370                 375                 380                 
Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His
385                 390                 395                 400 
Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu
                405                 410                 415     
Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg
            420                 425                 430         
Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu
        435                 440                 445             
Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln
    450                 455                 460                 
Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala
465                 470                 475                 480 
Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr
                485                 490                 495     
Glu Met Glu Met Leu Leu Asn Glu Lys Gly Gly Arg Ser Cys Ser Glu
            500                 505                 510         
Cys Asn Leu Glu
        515     


<210> 179
<211> 516
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 179
Met Gly Ser Asp Gly Ala Gly Ala Glu Glu Val Leu Ala Pro Leu Arg
 1               5                  10                  15      
Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys Leu Lys Glu Asp
            20                  25                  30          
Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala Glu Leu Lys Ala
        35                  40                  45              
Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys Asp
    50                  55                  60                  
Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu Lys Arg Arg Phe
65                  70                  75                  80  
Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr
                85                  90                  95      
Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn Ile Ile Gln Thr
            100                 105                 110         
Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys
        115                 120                 125             
Thr Met Leu Thr Pro Glu Pro Val Leu Lys Thr Ser Gly His Val Asp
    130                 135                 140                 
Lys Phe Ala Asp Phe Met Val Lys Asp Val Lys Asn Gly Glu Cys Phe
145                 150                 155                 160 
Arg Ala Asp His Leu Leu Lys Ala His Leu Gln Lys Leu Met Ser Asp
                165                 170                 175     
Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu Ser Val Leu Ala
            180                 185                 190         
Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp Leu Phe Val Asn
        195                 200                 205             
Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu Ser Pro Pro Val
    210                 215                 220                 
Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro Gly Gly Asn Met
225                 230                 235                 240 
Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile Phe Leu Asn Phe
                245                 250                 255     
Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro Phe Ala Ala Ala
            260                 265                 270         
Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro Arg Ser Gly Leu
        275                 280                 285             
Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu His Phe Val Asp
    290                 295                 300                 
Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val Ala Asp Leu His
305                 310                 315                 320 
Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly Gln Ser Ala Arg
                325                 330                 335     
Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val Ile Asn Asn Thr
            340                 345                 350         
Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr Leu Thr Lys Val
        355                 360                 365             
Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His Met Glu Asn Glu
    370                 375                 380                 
Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu Ser Lys Thr Ser
385                 390                 395                 400 
Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg Ser Cys Tyr Asp
                405                 410                 415     
Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu Val Ala Glu Lys
            420                 425                 430         
Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln Phe Glu Pro Ser
        435                 440                 445             
Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala Lys Leu Val Met
    450                 455                 460                 
Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr Glu Met Glu Met
465                 470                 475                 480 
Leu Leu Asn Glu Lys Gly Gly Arg Ser Cys Ser Glu Cys Asn Leu Glu
                485                 490                 495     
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His
            500                 505                 510         
His His His His
        515     


<210> 180
<211> 167
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with N-terminal
      6xHis  affinity tag

<400> 180
Met His His His His His His Gly Lys Pro Ile Pro Asn Pro Leu Leu
 1               5                  10                  15      
Gly Leu Asp Ser Thr Gly Ser Asp Gly Ala Gly Ala Glu Glu Val Leu
            20                  25                  30          
Ala Pro Leu Arg Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys
        35                  40                  45              
Leu Lys Glu Asp Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala
    50                  55                  60                  
Glu Leu Lys Ala Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu
65                  70                  75                  80  
Gln Pro Lys Asp Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu
                85                  90                  95      
Lys Arg Arg Phe Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val
            100                 105                 110         
Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn
        115                 120                 125             
Ile Ile Gln Thr Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu
    130                 135                 140                 
Glu Ile Asp Cys Thr Met Leu Thr Pro Glu Pro Val Leu Asn Ser Phe
145                 150                 155                 160 
Thr Glu Ile Asp Val Leu Glu
                165         


<210> 181
<211> 167
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycyl tRNA Synthetase polypeptide with C-terminal
      6xHis  affinity tag

<400> 181
Met Gly Ser Asp Gly Ala Gly Ala Glu Glu Val Leu Ala Pro Leu Arg
 1               5                  10                  15      
Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys Leu Lys Glu Asp
            20                  25                  30          
Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala Glu Leu Lys Ala
        35                  40                  45              
Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu Gln Pro Lys Asp
    50                  55                  60                  
Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu Lys Arg Arg Phe
65                  70                  75                  80  
Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val Ser Gly Leu Tyr
                85                  90                  95      
Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn Ile Ile Gln Thr
            100                 105                 110         
Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu Glu Ile Asp Cys
        115                 120                 125             
Thr Met Leu Thr Pro Glu Pro Val Leu Asn Ser Phe Thr Glu Ile Asp
    130                 135                 140                 
Val Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser
145                 150                 155                 160 
Thr His His His His His His
                165         


<210> 182
<211> 1485
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 182
ggatccgatg gtgccggagc tgaagaagtc ctggcccctc tgcgtctggc tgttcgtcaa 60
caaggtgatc tggtccgtaa actgaaagag gacaaagcac ctcaggttga tgtcgataaa 120
gcggtggcgg aactgaaagc ccgtaaacgt gttctggaag cgaaagagct ggccctgcaa 180
ccaaaagatg atatcgtgga ccgtgctaaa atggaggata ccctgaaacg tcgttttttc 240
tatgatcagg cgttcgccat ctatggtggt gttagcggtc tgtatgattt cggcccggtg 300
ggttgtgctc tgaaaaacaa catcatccaa acgtggcgtc agcatttcat ccaagaggag 360
caaatcctgg agattgactg taccatgctg acacctgagc cagtgctgaa aacctctggt 420
catgtggaca aattcgccga ctttatggtg aaagacgtga aaaatgggga gtgttttcgt 480
gccgaccatc tgctgaaagc acatctgcaa aaactgatga gcgataaaaa atgttccgtg 540
gaaaaaaaat ccgagatgga gagcgtactg gcccaactgg ataattatgg gcagcaagag 600
ctggcggacc tgtttgtgaa ctataacgtg aaaagcccga ttaccggcaa tgatctgtct 660
cctccggtga gcttcaatct gatgttcaaa acgttcatcg gtccgggtgg taatatgccg 720
ggttatctgc gcccagaaac agcacagggc atctttctga acttcaaacg tctgctggag 780
tttaatcagg gcaaactgcc gttcgctgct gctcaaatcg gcaacagctt tcgtaacgag 840
attagccctc gtagtgggct gatccgtgtc cgtgaattca ctatggctga gatcgaacac 900
tttgtggacc cgagcgaaaa agaccatcca aaattccaaa atgtggccga cctgcatctg 960
tatctgtata gtgccaaagc ccaggttagt ggtcagtctg ctcgtaaaat gcgcctgggt 1020
gatgccgtag aacagggcgt tatcaacaat accgtgctgg ggtatttcat tggccgtatc 1080
tatctgtatc tgacaaaagt gggcatttcg ccggataaac tgcgtttccg tcaacacatg 1140
gagaatgaga tggcccatta tgcctgtgat tgctgggatg ccgaatccaa aacctcgtat 1200
ggctggatcg aaattgtggg ctgtgctgac cgctcttgtt atgacctgag ctgccacgct 1260
cgtgctacaa aagttccgct ggttgccgaa aaacctctga aagaaccgaa aaccgtgaat 1320
gtggtacagt ttgagcctag taaaggggcg attggaaaag cttataaaaa agacgctaaa 1380
ctggtgatgg agtatctggc catctgtgac gaatgctata ttaccgaaat ggaaatgctg 1440
ctgaacgaaa aaggtggtcg ctcttgctct gagtgtaacc tcgag                 1485

<210> 183
<211> 438
<212> DNA
<213> Artificial Sequence

<220> 
<223> Codon optimized Glycyl tRNA Synthetase
      polynucleotide

<400> 183
ggatccgacg gggcaggagc ggaagaggtt ctggcaccac tgcgtctggc tgttcgtcaa 60
caaggtgacc tggtccgtaa actgaaagag gacaaagcac cacaagtcga tgtcgataaa 120
gccgttgctg aactgaaagc tcgtaaacgt gttctggagg ccaaagaact ggcactgcag 180
ccgaaagatg atatcgtgga tcgtgctaaa atggaggata ccctgaaacg tcgcttcttc 240
tatgatcagg cctttgccat ctatggtggc gttagtggac tgtatgactt cggtcctgtt 300
ggttgtgccc tgaaaaacaa cattattcag acatggcgcc agcacttcat tcaagaggag 360
cagattctgg aaattgattg taccatgctg accccggaac ctgtactgaa ttccttcacc 420
gagattgacg tgctcgag                                               438
