                         SEQUENCE LISTING

<110>  Bioftalmik, S.L.
 
<120>  METHOD FOR THE DIAGNOSIS OF DRY EYE AND BLEPHARITIS

<130>  P5744PC00

<150>  EP10382229.2
<151>  2010-08-10

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Arg Pro Leu Cys Thr Leu Leu Leu Leu Met Ala Thr Leu Ala 
1               5                   10                  15      


Gly Ala Leu Ala Ser Ser Ser Lys Glu Glu Asn Arg Ile Ile Pro Gly 
            20                  25                  30          


Gly Ile Tyr Asp Ala Asp Leu Asn Asp Glu Trp Val Gln Arg Ala Leu 
        35                  40                  45              


His Phe Ala Ile Ser Glu Tyr Asn Lys Ala Thr Glu Asp Glu Tyr Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Gln Val Leu Arg Ala Arg Glu Gln Thr Phe Gly Gly 
65                  70                  75                  80  


Val Asn Tyr Phe Phe Asp Val Glu Val Gly Arg Thr Ile Cys Thr Lys 
                85                  90                  95      


Ser Gln Pro Asn Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu 
            100                 105                 110         


Gln Lys Lys Gln Leu Cys Ser Phe Glu Ile Tyr Glu Val Pro Trp Glu 
        115                 120                 125             


Asp Arg Met Ser Leu Val Asn Ser Arg Cys Gln Glu Ala 
    130                 135                 140     


<210>  2
<211>  141
<212>  PRT
<213>  homo sapiens

<400>  2

Met Ala Gln His Leu Ser Thr Leu Leu Leu Leu Leu Ala Thr Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Trp Ser Pro Lys Glu Glu Asp Arg Ile Ile Pro Gly 
            20                  25                  30          


Gly Ile Tyr Asn Ala Asp Leu Asn Asp Glu Trp Val Gln Arg Ala Leu 
        35                  40                  45              


His Phe Ala Ile Ser Glu Tyr Asn Lys Ala Thr Lys Asp Asp Tyr Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Arg Val Leu Arg Ala Arg Gln Gln Thr Val Gly Gly 
65                  70                  75                  80  


Val Asn Tyr Phe Phe Asp Val Glu Val Gly Arg Thr Ile Cys Thr Lys 
                85                  90                  95      


Ser Gln Pro Asn Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu 
            100                 105                 110         


Gln Lys Lys Gln Leu Cys Ser Phe Glu Ile Tyr Glu Val Pro Trp Glu 
        115                 120                 125             


Asn Arg Arg Ser Leu Val Lys Ser Arg Cys Gln Glu Ser 
    130                 135                 140     


<210>  3
<211>  90
<212>  PRT
<213>  homo sapiens

<400>  3

Met Ala Cys Pro Leu Asp Gln Ala Ile Gly Leu Leu Val Ala Ile Phe 
1               5                   10                  15      


His Lys Tyr Ser Gly Arg Glu Gly Asp Lys His Thr Leu Ser Lys Lys 
            20                  25                  30          


Glu Leu Lys Glu Leu Ile Gln Lys Glu Leu Thr Ile Gly Ser Lys Leu 
        35                  40                  45              


Gln Asp Ala Glu Ile Ala Arg Leu Met Glu Asp Leu Asp Arg Asn Lys 
    50                  55                  60                  


Asp Gln Glu Val Asn Phe Gln Glu Tyr Val Thr Phe Leu Gly Ala Leu 
65                  70                  75                  80  


Ala Leu Ile Tyr Asn Glu Ala Leu Lys Gly 
                85                  90  


<210>  4
<211>  114
<212>  PRT
<213>  homo sapiens

<400>  4

Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 
1               5                   10                  15      


Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 
            20                  25                  30          


Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 
        35                  40                  45              


Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 
    50                  55                  60                  


Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 
65                  70                  75                  80  


Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 
                85                  90                  95      


Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 
            100                 105                 110         


Thr Pro 
        


<210>  5
<211>  210
<212>  PRT
<213>  homo sapiens

<400>  5

Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala 
1               5                   10                  15      


Ala Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu 
            20                  25                  30          


Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys 
        35                  40                  45              


Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr 
    50                  55                  60                  


Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr 
65                  70                  75                  80  


Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly 
                85                  90                  95      


Val Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr 
            100                 105                 110         


Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys 
        115                 120                 125             


Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile 
    130                 135                 140                 


Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu 
145                 150                 155                 160 


Leu Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu 
                165                 170                 175     


Leu Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala 
            180                 185                 190         


Phe Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
        195                 200                 205             


Lys Gln 
    210 


<210>  6
<211>  136
<212>  PRT
<213>  homo sapiens

<400>  6

Met Ser Asn Val Pro His Lys Ser Ser Leu Pro Glu Gly Ile Arg Pro 
1               5                   10                  15      


Gly Thr Val Leu Arg Ile Arg Gly Leu Val Pro Pro Asn Ala Ser Arg 
            20                  25                  30          


Phe His Val Asn Leu Leu Cys Gly Glu Glu Gln Gly Ser Asp Ala Ala 
        35                  40                  45              


Leu His Phe Asn Pro Arg Leu Asp Thr Ser Glu Val Val Phe Asn Ser 
    50                  55                  60                  


Lys Glu Gln Gly Ser Trp Gly Arg Glu Glu Arg Gly Pro Gly Val Pro 
65                  70                  75                  80  


Phe Gln Arg Gly Gln Pro Phe Glu Val Leu Ile Ile Ala Ser Asp Asp 
                85                  90                  95      


Gly Phe Lys Ala Val Val Gly Asp Ala Gln Tyr His His Phe Arg His 
            100                 105                 110         


Arg Leu Pro Leu Ala Arg Val Arg Leu Val Glu Val Gly Gly Asp Val 
        115                 120                 125             


Gln Leu Asp Ser Val Arg Ile Phe 
    130                 135     


<210>  7
<211>  346
<212>  PRT
<213>  homo sapiens

<400>  7

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  8
<211>  391
<212>  PRT
<213>  homo sapiens

<400>  8

Met Asp Ser Leu Gly Ala Val Ser Thr Arg Leu Gly Phe Asp Leu Phe 
1               5                   10                  15      


Lys Glu Leu Lys Lys Thr Asn Asp Gly Asn Ile Phe Phe Ser Pro Val 
            20                  25                  30          


Gly Ile Leu Thr Ala Ile Gly Met Val Leu Leu Gly Thr Arg Gly Ala 
        35                  40                  45              


Thr Ala Ser Gln Leu Glu Glu Val Phe His Ser Glu Lys Glu Thr Lys 
    50                  55                  60                  


Ser Ser Arg Ile Lys Ala Glu Glu Lys Glu Val Ile Glu Asn Thr Glu 
65                  70                  75                  80  


Ala Val His Gln Gln Phe Gln Lys Phe Leu Thr Glu Ile Ser Lys Leu 
                85                  90                  95      


Thr Asn Asp Tyr Glu Leu Asn Ile Thr Asn Arg Leu Phe Gly Glu Lys 
            100                 105                 110         


Thr Tyr Leu Phe Leu Gln Lys Tyr Leu Asp Tyr Val Glu Lys Tyr Tyr 
        115                 120                 125             


His Ala Ser Leu Glu Pro Val Asp Phe Val Asn Ala Ala Asp Glu Ser 
    130                 135                 140                 


Arg Lys Lys Ile Asn Ser Trp Val Glu Ser Lys Thr Asn Glu Lys Ile 
145                 150                 155                 160 


Lys Asp Leu Phe Pro Asp Gly Ser Ile Ser Ser Ser Thr Lys Leu Val 
                165                 170                 175     


Leu Val Asn Met Val Tyr Phe Lys Gly Gln Trp Asp Arg Glu Phe Lys 
            180                 185                 190         


Lys Glu Asn Thr Lys Glu Glu Lys Phe Trp Met Asn Lys Ser Thr Ser 
        195                 200                 205             


Lys Ser Val Gln Met Met Thr Gln Ser His Ser Phe Ser Phe Thr Phe 
    210                 215                 220                 


Leu Glu Asp Leu Gln Ala Lys Ile Leu Gly Ile Pro Tyr Lys Asn Asn 
225                 230                 235                 240 


Asp Leu Ser Met Phe Val Leu Leu Pro Asn Asp Ile Asp Gly Leu Glu 
                245                 250                 255     


Lys Ile Ile Asp Lys Ile Ser Pro Glu Lys Leu Val Glu Trp Thr Ser 
            260                 265                 270         


Pro Gly His Met Glu Glu Arg Lys Val Asn Leu His Leu Pro Arg Phe 
        275                 280                 285             


Glu Val Glu Asp Gly Tyr Asp Leu Glu Ala Val Leu Ala Ala Met Gly 
    290                 295                 300                 


Met Gly Asp Ala Phe Ser Glu His Lys Ala Asp Tyr Ser Gly Met Ser 
305                 310                 315                 320 


Ser Gly Ser Gly Leu Tyr Ala Gln Lys Phe Leu His Ser Ser Phe Val 
                325                 330                 335     


Ala Val Thr Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Gly Ile Gly 
            340                 345                 350         


Phe Thr Val Thr Ser Ala Pro Gly His Glu Asn Val His Cys Asn His 
        355                 360                 365             


Pro Phe Leu Phe Phe Ile Arg His Asn Glu Ser Asn Ser Ile Leu Phe 
    370                 375                 380                 


Phe Gly Arg Phe Ser Ser Pro 
385                 390     


<210>  9
<211>  331
<212>  PRT
<213>  homo sapiens

<400>  9

Met Ala Arg Gly Gly Arg Gly Arg Arg Leu Gly Leu Ala Leu Gly Leu 
1               5                   10                  15      


Leu Leu Ala Leu Val Leu Ala Pro Arg Val Leu Arg Ala Lys Pro Thr 
            20                  25                  30          


Val Arg Lys Glu Arg Val Val Arg Pro Asp Ser Glu Leu Gly Glu Arg 
        35                  40                  45              


Pro Pro Glu Asp Asn Gln Ser Phe Gln Tyr Asp His Glu Ala Phe Leu 
    50                  55                  60                  


Gly Lys Glu Asp Ser Lys Thr Phe Asp Gln Leu Thr Pro Asp Glu Ser 
65                  70                  75                  80  


Lys Glu Arg Leu Gly Lys Ile Val Asp Arg Ile Asp Asn Asp Gly Asp 
                85                  90                  95      


Gly Phe Val Thr Thr Glu Glu Leu Lys Thr Trp Ile Lys Arg Val Gln 
            100                 105                 110         


Lys Arg Tyr Ile Phe Asp Asn Val Ala Lys Val Trp Lys Asp Tyr Asp 
        115                 120                 125             


Arg Asp Lys Asp Asp Lys Ile Ser Trp Glu Glu Tyr Lys Gln Ala Thr 
    130                 135                 140                 


Tyr Gly Tyr Tyr Leu Gly Asn Pro Ala Glu Phe His Asp Ser Ser Asp 
145                 150                 155                 160 


His His Thr Phe Lys Lys Met Leu Pro Arg Asp Glu Arg Arg Phe Lys 
                165                 170                 175     


Ala Ala Asp Leu Asn Gly Asp Leu Thr Ala Thr Arg Glu Glu Phe Thr 
            180                 185                 190         


Ala Phe Leu His Pro Glu Glu Phe Glu His Met Lys Glu Ile Val Val 
        195                 200                 205             


Leu Glu Thr Leu Glu Asp Ile Asp Lys Asn Gly Asp Gly Phe Val Asp 
    210                 215                 220                 


Gln Asp Glu Tyr Ile Ala Asp Met Phe Ser His Glu Glu Asn Gly Pro 
225                 230                 235                 240 


Glu Pro Asp Trp Val Leu Ser Glu Arg Glu Gln Phe Asn Glu Phe Arg 
                245                 250                 255     


Asp Leu Asn Lys Asp Gly Lys Leu Asp Lys Asp Glu Ile Arg His Trp 
            260                 265                 270         


Ile Leu Pro Gln Asp Tyr Asp His Ala Gln Ala Glu Ala Arg His Leu 
        275                 280                 285             


Val Tyr Glu Ser Asp Lys Asn Lys Asp Glu Lys Leu Thr Lys Glu Glu 
    290                 295                 300                 


Ile Leu Glu Asn Trp Asn Met Phe Val Gly Ser Gln Ala Thr Asn Tyr 
305                 310                 315                 320 


Gly Glu Asp Leu Thr Lys Asn His Asp Glu Leu 
                325                 330     


<210>  10
<211>  222
<212>  PRT
<213>  homo sapiens

<400>  10

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Ala 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln 
        35                  40                  45              


Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val 
    50                  55                  60                  


Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Asp Val Thr Ala 
65                  70                  75                  80  


Gln Ile Ala Leu Gln Pro Ala Leu Lys Phe Asn Gly Gly Gly His Ile 
                85                  90                  95      


Asn His Ser Ile Phe Trp Thr Asn Leu Ser Pro Asn Gly Gly Gly Glu 
            100                 105                 110         


Pro Lys Gly Glu Leu Leu Glu Ala Ile Lys Arg Asp Phe Gly Ser Phe 
        115                 120                 125             


Asp Lys Phe Lys Glu Lys Leu Thr Ala Ala Ser Val Gly Val Gln Gly 
    130                 135                 140                 


Ser Gly Trp Gly Trp Leu Gly Phe Asn Lys Glu Arg Gly His Leu Gln 
145                 150                 155                 160 


Ile Ala Ala Cys Pro Asn Gln Asp Pro Leu Gln Gly Thr Thr Gly Leu 
                165                 170                 175     


Ile Pro Leu Leu Gly Ile Asp Val Trp Glu His Ala Tyr Tyr Leu Gln 
            180                 185                 190         


Tyr Lys Asn Val Arg Pro Asp Tyr Leu Lys Ala Ile Trp Asn Val Ile 
        195                 200                 205             


Asn Trp Glu Asn Val Thr Glu Arg Tyr Met Ala Cys Lys Lys 
    210                 215                 220         


<210>  11
<211>  425
<212>  PRT
<213>  homo sapiens

<400>  11

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Ile Val Lys Arg Leu Leu 
1               5                   10                  15      


Gly Trp Lys Lys Gly Glu Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu 
            20                  25                  30          


Lys Ala Val Lys Ser Leu Val Lys Lys Leu Lys Lys Thr Gly Gln Leu 
        35                  40                  45              


Asp Glu Leu Glu Lys Ala Ile Thr Thr Gln Asn Val Asn Thr Lys Cys 
    50                  55                  60                  


Ile Thr Ile Pro Arg Ser Leu Asp Gly Arg Leu Gln Val Ser His Arg 
65                  70                  75                  80  


Lys Gly Leu Pro His Val Ile Tyr Cys Arg Leu Trp Arg Trp Pro Asp 
                85                  90                  95      


Leu His Ser His His Glu Leu Arg Ala Met Glu Leu Cys Glu Phe Ala 
            100                 105                 110         


Phe Asn Met Lys Lys Asp Glu Val Cys Val Asn Pro Tyr His Tyr Gln 
        115                 120                 125             


Arg Val Glu Thr Pro Val Leu Pro Pro Val Leu Val Pro Arg His Thr 
    130                 135                 140                 


Glu Ile Pro Ala Glu Phe Pro Pro Leu Asp Asp Tyr Ser His Ser Ile 
145                 150                 155                 160 


Pro Glu Asn Thr Asn Phe Pro Ala Gly Ile Glu Pro Gln Ser Asn Ile 
                165                 170                 175     


Pro Glu Thr Pro Pro Pro Gly Tyr Leu Ser Glu Asp Gly Glu Thr Ser 
            180                 185                 190         


Asp His Gln Met Asn His Ser Met Asp Ala Gly Ser Pro Asn Leu Ser 
        195                 200                 205             


Pro Asn Pro Met Ser Pro Ala His Asn Asn Leu Asp Leu Gln Pro Val 
    210                 215                 220                 


Thr Tyr Cys Glu Pro Ala Phe Trp Cys Ser Ile Ser Tyr Tyr Glu Leu 
225                 230                 235                 240 


Asn Gln Arg Val Gly Glu Thr Phe His Ala Ser Gln Pro Ser Met Thr 
                245                 250                 255     


Val Asp Gly Phe Thr Asp Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly 
            260                 265                 270         


Leu Leu Ser Asn Val Asn Arg Asn Ala Ala Val Glu Leu Thr Arg Arg 
        275                 280                 285             


His Ile Gly Arg Gly Val Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe 
    290                 295                 300                 


Ala Glu Cys Leu Ser Asp Ser Ala Ile Phe Val Gln Ser Pro Asn Cys 
305                 310                 315                 320 


Asn Gln Arg Tyr Gly Trp His Pro Ala Thr Val Cys Lys Ile Pro Pro 
                325                 330                 335     


Gly Cys Asn Leu Lys Ile Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu 
            340                 345                 350         


Ala Gln Ser Val Asn Gln Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg 
        355                 360                 365             


Met Cys Thr Ile Arg Met Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr 
    370                 375                 380                 


Arg Arg Gln Thr Val Thr Ser Thr Pro Cys Trp Ile Glu Leu His Leu 
385                 390                 395                 400 


Asn Gly Pro Leu Gln Trp Leu Asp Lys Val Leu Thr Gln Met Gly Ser 
                405                 410                 415     


Pro Ser Ile Arg Cys Ser Ser Val Ser 
            420                 425 


<210>  12
<211>  427
<212>  PRT
<213>  homo sapiens

<400>  12

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Leu 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Val Cys His Lys Ile Leu 
    210                 215                 220                 


Phe Pro Gly Arg Asp Tyr Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Gly Ala Ala Val Ile 
    370                 375                 380                 


Asn Gly Ser Gln His Pro Ser Ser Ser Ser Ser Val Asn Asp Val Ser 
385                 390                 395                 400 


Ser Met Ser Thr Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu 
                405                 410                 415     


Glu Ala Ala Ala Gly Pro Leu Gly Cys Cys Arg 
            420                 425         


<210>  13
<211>  795
<212>  PRT
<213>  homo sapiens

<400>  13

Met Thr Ser Gly Ala Thr Arg Tyr Arg Leu Ser Cys Ser Leu Arg Gly 
1               5                   10                  15      


His Glu Leu Asp Val Arg Gly Leu Val Cys Cys Ala Tyr Pro Pro Gly 
            20                  25                  30          


Ala Phe Val Ser Val Ser Arg Asp Arg Thr Thr Arg Leu Trp Ala Pro 
        35                  40                  45              


Asp Ser Pro Asn Arg Ser Phe Thr Glu Met His Cys Met Ser Gly His 
    50                  55                  60                  


Ser Asn Phe Val Ser Cys Val Cys Ile Ile Pro Ser Ser Asp Ile Tyr 
65                  70                  75                  80  


Pro His Gly Leu Ile Ala Thr Gly Gly Asn Asp His Asn Ile Cys Ile 
                85                  90                  95      


Phe Ser Leu Asp Ser Pro Met Pro Leu Tyr Ile Leu Lys Gly His Lys 
            100                 105                 110         


Asn Thr Val Cys Ser Leu Ser Ser Gly Lys Phe Gly Thr Leu Leu Ser 
        115                 120                 125             


Gly Ser Trp Asp Thr Thr Ala Lys Val Trp Leu Asn Asp Lys Cys Met 
    130                 135                 140                 


Met Thr Leu Gln Gly His Thr Ala Ala Val Trp Ala Val Lys Ile Leu 
145                 150                 155                 160 


Pro Glu Gln Gly Leu Met Leu Thr Gly Ser Ala Asp Lys Thr Val Lys 
                165                 170                 175     


Leu Trp Lys Ala Gly Arg Cys Glu Arg Thr Phe Ser Gly His Glu Asp 
            180                 185                 190         


Cys Val Arg Gly Leu Ala Ile Leu Ser Glu Thr Glu Phe Leu Ser Cys 
        195                 200                 205             


Ala Asn Asp Ala Ser Ile Arg Arg Trp Gln Ile Thr Gly Glu Cys Leu 
    210                 215                 220                 


Glu Val Tyr Tyr Gly His Thr Asn Tyr Ile Tyr Ser Ile Ser Val Phe 
225                 230                 235                 240 


Pro Asn Cys Arg Asp Phe Val Thr Thr Ala Glu Asp Arg Ser Leu Arg 
                245                 250                 255     


Ile Trp Lys His Gly Glu Cys Ala Gln Thr Ile Arg Leu Pro Ala Gln 
            260                 265                 270         


Ser Ile Trp Cys Cys Cys Val Leu Asp Asn Gly Asp Ile Val Val Gly 
        275                 280                 285             


Ala Ser Asp Gly Ile Ile Arg Val Phe Thr Glu Ser Glu Asp Arg Thr 
    290                 295                 300                 


Ala Ser Ala Glu Glu Ile Lys Ala Phe Glu Lys Glu Leu Ser His Ala 
305                 310                 315                 320 


Thr Ile Asp Ser Lys Thr Gly Asp Leu Gly Asp Ile Asn Ala Glu Gln 
                325                 330                 335     


Leu Pro Gly Arg Glu His Leu Asn Glu Pro Gly Thr Arg Glu Gly Gln 
            340                 345                 350         


Thr Arg Leu Ile Arg Asp Gly Glu Lys Val Glu Ala Tyr Gln Trp Ser 
        355                 360                 365             


Val Ser Glu Gly Arg Trp Ile Lys Ile Gly Asp Val Val Gly Ser Ser 
    370                 375                 380                 


Gly Ala Asn Gln Gln Thr Ser Gly Lys Val Leu Tyr Glu Gly Lys Glu 
385                 390                 395                 400 


Phe Asp Tyr Val Phe Ser Ile Asp Val Asn Glu Gly Gly Pro Ser Tyr 
                405                 410                 415     


Lys Leu Pro Tyr Asn Thr Ser Asp Asp Pro Trp Leu Thr Ala Tyr Asn 
            420                 425                 430         


Phe Leu Gln Lys Asn Asp Leu Asn Pro Met Phe Leu Asp Gln Val Ala 
        435                 440                 445             


Lys Phe Ile Ile Asp Asn Thr Lys Gly Gln Met Leu Gly Leu Gly Asn 
    450                 455                 460                 


Pro Ser Phe Ser Asp Pro Phe Thr Gly Gly Gly Arg Tyr Val Pro Gly 
465                 470                 475                 480 


Ser Ser Gly Ser Ser Asn Thr Leu Pro Thr Ala Asp Pro Phe Thr Gly 
                485                 490                 495     


Ala Gly Arg Tyr Val Pro Gly Ser Ala Ser Met Gly Thr Thr Met Ala 
            500                 505                 510         


Gly Val Asp Pro Phe Thr Gly Asn Ser Ala Tyr Arg Ser Ala Ala Ser 
        515                 520                 525             


Lys Thr Met Asn Ile Tyr Phe Pro Lys Lys Glu Ala Val Thr Phe Asp 
    530                 535                 540                 


Gln Ala Asn Pro Thr Gln Ile Leu Gly Lys Leu Lys Glu Leu Asn Gly 
545                 550                 555                 560 


Thr Ala Pro Glu Glu Lys Lys Leu Thr Glu Asp Asp Leu Ile Leu Leu 
                565                 570                 575     


Glu Lys Ile Leu Ser Leu Ile Cys Asn Ser Ser Ser Glu Lys Pro Thr 
            580                 585                 590         


Val Gln Gln Leu Gln Ile Leu Trp Lys Ala Ile Asn Cys Pro Glu Asp 
        595                 600                 605             


Ile Val Phe Pro Ala Leu Asp Ile Leu Arg Leu Ser Ile Lys His Pro 
    610                 615                 620                 


Ser Val Asn Glu Asn Phe Cys Asn Glu Lys Glu Gly Ala Gln Phe Ser 
625                 630                 635                 640 


Ser His Leu Ile Asn Leu Leu Asn Pro Lys Gly Lys Pro Ala Asn Gln 
                645                 650                 655     


Leu Leu Ala Leu Arg Thr Phe Cys Asn Cys Phe Val Gly Gln Ala Gly 
            660                 665                 670         


Gln Lys Leu Met Met Ser Gln Arg Glu Ser Leu Met Ser His Ala Ile 
        675                 680                 685             


Glu Leu Lys Ser Gly Ser Asn Lys Asn Ile His Ile Ala Leu Ala Thr 
    690                 695                 700                 


Leu Ala Leu Asn Tyr Ser Val Cys Phe His Lys Asp His Asn Ile Glu 
705                 710                 715                 720 


Gly Lys Ala Gln Cys Leu Ser Leu Ile Ser Thr Ile Leu Glu Val Val 
                725                 730                 735     


Gln Asp Leu Glu Ala Thr Phe Arg Leu Leu Val Ala Leu Gly Thr Leu 
            740                 745                 750         


Ile Ser Asp Asp Ser Asn Ala Val Gln Leu Ala Lys Ser Leu Gly Val 
        755                 760                 765             


Asp Ser Gln Ile Lys Lys Tyr Ser Ser Val Ser Glu Pro Ala Lys Val 
    770                 775                 780                 


Ser Glu Cys Cys Arg Phe Ile Leu Asn Leu Leu 
785                 790                 795 


<210>  14
<211>  218
<212>  PRT
<213>  homo sapiens

<400>  14

Met Pro Met Thr Leu Gly Tyr Trp Asn Ile Arg Gly Leu Ala His Ser 
1               5                   10                  15      


Ile Arg Leu Leu Leu Glu Tyr Thr Asp Ser Ser Tyr Glu Glu Lys Lys 
            20                  25                  30          


Tyr Thr Met Gly Asp Ala Pro Asp Tyr Asp Arg Ser Gln Trp Leu Asn 
        35                  40                  45              


Glu Lys Phe Lys Leu Gly Leu Asp Phe Pro Asn Leu Pro Tyr Leu Ile 
    50                  55                  60                  


Asp Gly Thr His Lys Ile Thr Gln Ser Asn Ala Ile Leu Arg Tyr Ile 
65                  70                  75                  80  


Ala Arg Lys His Asn Leu Cys Gly Glu Ser Glu Lys Glu Gln Ile Arg 
                85                  90                  95      


Glu Asp Ile Leu Glu Asn Gln Phe Met Asp Ser Arg Met Gln Leu Ala 
            100                 105                 110         


Lys Leu Cys Tyr Asp Pro Asp Phe Glu Lys Leu Lys Pro Glu Tyr Leu 
        115                 120                 125             


Gln Ala Leu Pro Glu Met Leu Lys Leu Tyr Ser Gln Phe Leu Gly Lys 
    130                 135                 140                 


Gln Pro Trp Phe Leu Gly Asp Lys Ile Thr Phe Val Asp Phe Ile Ala 
145                 150                 155                 160 


Tyr Asp Val Leu Glu Arg Asn Gln Val Phe Glu Pro Ser Cys Leu Asp 
                165                 170                 175     


Ala Phe Pro Asn Leu Lys Asp Phe Ile Ser Arg Phe Glu Gly Leu Glu 
            180                 185                 190         


Lys Ile Ser Ala Tyr Met Lys Ser Ser Arg Phe Leu Pro Arg Pro Val 
        195                 200                 205             


Phe Thr Lys Met Ala Val Trp Gly Asn Lys 
    210                 215             


<210>  15
<211>  222
<212>  PRT
<213>  homo sapiens

<400>  15

Met Ala Ala Arg Pro Lys Leu His Tyr Pro Asn Gly Arg Gly Arg Met 
1               5                   10                  15      


Glu Ser Val Arg Trp Val Leu Ala Ala Ala Gly Val Glu Phe Asp Glu 
            20                  25                  30          


Glu Phe Leu Glu Thr Lys Glu Gln Leu Tyr Lys Leu Gln Asp Gly Asn 
        35                  40                  45              


His Leu Leu Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
    50                  55                  60                  


Leu Val Gln Thr Arg Ser Ile Leu His Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Leu Phe Gly Lys Asn Leu Lys Glu Arg Thr Leu Ile Asp Met Tyr Val 
                85                  90                  95      


Glu Gly Thr Leu Asp Leu Leu Glu Leu Leu Ile Met His Pro Phe Leu 
            100                 105                 110         


Lys Pro Asp Asp Gln Gln Lys Glu Val Val Asn Met Ala Gln Lys Ala 
        115                 120                 125             


Ile Ile Arg Tyr Phe Pro Val Phe Glu Lys Ile Leu Arg Gly His Gly 
    130                 135                 140                 


Gln Ser Phe Leu Val Gly Asn Gln Leu Ser Leu Ala Asp Val Ile Leu 
145                 150                 155                 160 


Leu Gln Thr Ile Leu Ala Leu Glu Glu Lys Ile Pro Asn Ile Leu Ser 
                165                 170                 175     


Ala Phe Pro Phe Leu Gln Glu Tyr Thr Val Lys Leu Ser Asn Ile Pro 
            180                 185                 190         


Thr Ile Lys Arg Phe Leu Glu Pro Gly Ser Lys Lys Lys Pro Pro Pro 
        195                 200                 205             


Asp Glu Ile Tyr Val Arg Thr Val Tyr Asn Ile Phe Arg Pro 
    210                 215                 220         


<210>  16
<211>  408
<212>  PRT
<213>  homo sapiens

<400>  16

Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala Lys 
1               5                   10                  15      


Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro Arg 
            20                  25                  30          


Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val Pro 
        35                  40                  45              


Leu Glu Ile Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr Asp 
    50                  55                  60                  


Phe Asn Val Ile Val Glu Ala Leu Ser Lys Ser Lys Ala Glu Leu Met 
65                  70                  75                  80  


Glu Ile Ser Glu Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Lys Pro 
                85                  90                  95      


Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg Ser 
            100                 105                 110         


Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile Lys 
        115                 120                 125             


Glu Trp Leu Glu Asp Lys Gly Gln Val Leu Asn Ile Gln Met Arg Arg 
    130                 135                 140                 


Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp Ser 
145                 150                 155                 160 


Ile Glu Ser Ala Lys Lys Phe Val Glu Thr Pro Gly Gln Lys Tyr Lys 
                165                 170                 175     


Glu Thr Asp Leu Leu Ile Leu Phe Lys Asp Asp Tyr Phe Ala Lys Lys 
            180                 185                 190         


Asn Glu Glu Arg Lys Gln Asn Lys Val Glu Ala Lys Leu Arg Ala Lys 
        195                 200                 205             


Gln Glu Gln Glu Ala Lys Gln Lys Leu Glu Glu Asp Ala Glu Met Lys 
    210                 215                 220                 


Ser Leu Glu Glu Lys Ile Gly Cys Leu Leu Lys Phe Ser Gly Asp Leu 
225                 230                 235                 240 


Asp Asp Gln Thr Cys Arg Glu Asp Leu His Ile Leu Phe Ser Asn His 
                245                 250                 255     


Gly Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly Ile 
            260                 265                 270         


Ile Leu Phe Lys Glu Lys Ala Lys Glu Ala Leu Gly Lys Ala Lys Asp 
        275                 280                 285             


Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp Glu 
    290                 295                 300                 


Val Leu Glu Gly Glu Val Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu 
305                 310                 315                 320 


Asp Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Arg Arg Phe 
                325                 330                 335     


Lys Gly Lys Gly Lys Gly Asn Lys Ala Ala Gln Pro Gly Ser Gly Lys 
            340                 345                 350         


Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe Ala Ser Asp Asp 
        355                 360                 365             


Glu His Asp Glu His Asp Glu Asn Gly Ala Thr Gly Pro Val Lys Arg 
    370                 375                 380                 


Ala Arg Glu Glu Thr Asp Lys Glu Glu Pro Ala Ser Lys Gln Gln Lys 
385                 390                 395                 400 


Thr Glu Asn Gly Ala Gly Asp Gln 
                405             


<210>  17
<211>  505
<212>  PRT
<213>  homo sapiens

<400>  17

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp 
            500                 505 


<210>  18
<211>  90
<212>  PRT
<213>  homo sapiens

<400>  18

Met Arg Leu Ser Val Cys Leu Leu Leu Leu Thr Leu Ala Leu Cys Cys 
1               5                   10                  15      


Tyr Arg Ala Asn Ala Val Val Cys Gln Ala Leu Gly Ser Glu Ile Thr 
            20                  25                  30          


Gly Phe Leu Leu Ala Gly Lys Pro Val Phe Lys Phe Gln Leu Ala Lys 
        35                  40                  45              


Phe Lys Ala Pro Leu Glu Ala Val Ala Ala Lys Met Glu Val Lys Lys 
    50                  55                  60                  


Cys Val Asp Thr Met Ala Tyr Glu Lys Arg Val Leu Ile Thr Lys Thr 
65                  70                  75                  80  


Leu Gly Lys Ile Ala Glu Lys Cys Asp Arg 
                85                  90  


<210>  19
<211>  214
<212>  PRT
<213>  homo sapiens

<400>  19

Met Gly Leu Ala Gly Val Cys Ala Leu Arg Arg Ser Ala Gly Tyr Ile 
1               5                   10                  15      


Leu Val Gly Gly Ala Gly Gly Gln Ser Ala Ala Ala Ala Ala Arg Arg 
            20                  25                  30          


Cys Ser Glu Gly Glu Trp Ala Ser Gly Gly Val Arg Ser Phe Ser Arg 
        35                  40                  45              


Ala Ala Ala Ala Met Ala Pro Ile Lys Val Gly Asp Ala Ile Pro Ala 
    50                  55                  60                  


Val Glu Val Phe Glu Gly Glu Pro Gly Asn Lys Val Asn Leu Ala Glu 
65                  70                  75                  80  


Leu Phe Lys Gly Lys Lys Gly Val Leu Phe Gly Val Pro Gly Ala Phe 
                85                  90                  95      


Thr Pro Gly Cys Ser Lys Thr His Leu Pro Gly Phe Val Glu Gln Ala 
            100                 105                 110         


Glu Ala Leu Lys Ala Lys Gly Val Gln Val Val Ala Cys Leu Ser Val 
        115                 120                 125             


Asn Asp Ala Phe Val Thr Gly Glu Trp Gly Arg Ala His Lys Ala Glu 
    130                 135                 140                 


Gly Lys Val Arg Leu Leu Ala Asp Pro Thr Gly Ala Phe Gly Lys Glu 
145                 150                 155                 160 


Thr Asp Leu Leu Leu Asp Asp Ser Leu Val Ser Ile Phe Gly Asn Arg 
                165                 170                 175     


Arg Leu Lys Arg Phe Ser Met Val Val Gln Asp Gly Ile Val Lys Ala 
            180                 185                 190         


Leu Asn Val Glu Pro Asp Gly Thr Gly Leu Thr Cys Ser Leu Ala Pro 
        195                 200                 205             


Asn Ile Ile Ser Gln Leu 
    210                 


