                         SEQUENCE LISTING

<110>  Roche Glycart AG
 
<120>  Anti-Tenascin-C A2 Antibodies and Methods of Use

<130>  26952

<150>  EP 10172841.8
<151>  2010-08-13

<160>  136   

<170>  PatentIn version 3.5

<210>  1
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Library Template for DP47-3 library

<400>  1
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggccgaaa tcgtgttaac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga      120

gccaccctct cttgcagggc cagtcagagt gttagcagca gctacttagc ctggtaccag      180

cagaaacctg gccaggctcc caggctcctc atctatggag catccagcag ggccactggc      240

atcccagaca ggttcagtgg cagtggatcc gggacagact tcactctcac catcagcaga      300

ctggagcctg aagattttgc agtgtattac tgtcagcagt atggtagctc accgctgacg      360

ttcggccagg ggaccaaagt ggaaatcaaa cgtacggtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg tggagccgca      720

gaacaaaaac tcatctcaga agaggatctg aatggagccg cagactacaa ggacgacgac      780

gacaagggtg ccgcataata aggcgcgcca attctatttc aaggagacag tcatatgaaa      840

tacctgctgc cgaccgctgc tgctggtctg ctgctcctcg ctgcccagcc ggcgatggcc      900

gaggtgcaat tgctggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      960

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct     1020

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac     1080

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat     1140

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaccgttt     1200

ccgtattttg actactgggg ccaaggaacc ctggtcaccg tctcgagtgc tagcaccaaa     1260

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc     1320

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc     1380

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc     1440

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac     1500

gtgaatcaca agcccagcaa caccaaagtg gacaagaaag ttgagcccaa atcttgtgac     1560

gcggccgcaa gcactagtgc ccatcaccat caccatcacg ccgcggcata g              1611


<210>  2
<211>  1617
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Library Template for DP88-3 library

<400>  2
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggccgata tccagatgac ccagtctcca tcctccctgt ctgcatctgt cggagaccgg      120

gtcaccatca cctgccgggc aagtcagggc attagaaatg atttaggctg gtaccagcag      180

aagccaggga aagcccctaa gcgcctgatc tatgctgcat ccagtttgca gagtggcgtc      240

ccatcaaggt tcagcggcag tggatccggg acagagttca ctctcaccat cagcagcttg      300

cagcctgaag attttgccac ctattactgc ttgcagcata atagttaccc cacgtttggc      360

cagggcacca aagtcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagc cgcagaacaa      720

aaactcatct cagaagagga tctgaatgga gccgcagact acaaggacga cgacgacaag      780

ggtgccgcat aataaggcgc gccaattcta tttcaaggag acagtcatat gaaatacctg      840

ctgccgaccg ctgctgctgg tctgctgctc ctcgctgccc agccggcgat ggcccaggtg      900

caattggtgc agtctggggc tgaggtgaag aagcctgggt cctcggtgaa ggtctcctgc      960

aaggcctccg gaggcacatt cagcagctac gctataagct gggtgcgaca ggcccctgga     1020

caagggctcg agtggatggg agggatcatc cctatctttg gtacagcaaa ctacgcacag     1080

aagttccagg gcagggtcac cattactgca gacaaatcca cgagcacagc ctacatggag     1140

ctgagcagcc tgagatctga ggacaccgcc gtgtattact gtgcgagact atccccaggc     1200

ggttactatg ttatggatgc ctggggccaa gggaccaccg tgaccgtctc ctcagctagc     1260

accaaaggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca     1320

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac     1380

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     1440

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     1500

tgcaacgtga atcacaagcc cagcaacacc aaagtggaca agaaagttga gcccaaatct     1560

tgtgacgcgg ccgcaagcac tagtgcccat caccatcacc atcacgccgc ggcatag        1617


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat

<400>  3

Ser Tyr Ala Ile Ser 
1               5   


<210>  4
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (DNA 1)

<400>  4
agctacgcta taagc                                                        15


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia

<400>  5

Gly Gly Thr Phe Ser Ser Tyr 
1               5           


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (DNA1)

<400>  6
ggaggcacat tcagcagcta c                                                 21


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM

<400>  7

Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   10  


<210>  8
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (DNA1)

<400>  8
ggaggcacat tcagcagcta cgctataagc                                        30


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (1)

<400>  9

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


<210>  10
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (1) (DNA)

<400>  10
gggatcatcc ctatctttgg tacagcaaac tacgcacaga agttccag                    48


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (2)

<400>  11

Ala Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


<210>  12
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (2) (DNA)

<400>  12
gctatcatcc cgatccttgg tatcgcaaac tacgcacaga agttccag                    48


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (3)

<400>  13

Val Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


<210>  14
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (3) (DNA)

<400>  14
gtgatcatcc ctatccttgg taccgcaaac tacgcacaga agttccag                    48


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (1)

<400>  15

Ile Pro Ile Phe Gly Thr Ala Asn 
1               5               


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (1) (DNA)

<400>  16
atccctatct ttggtacagc a                                                 21


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (2)

<400>  17

Ile Pro Ile Leu Gly Ile Ala Asn 
1               5               


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (2) (DNA)

<400>  18
atcccgatcc ttggtatcgc a                                                 21


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (3)

<400>  19

Ile Pro Ile Leu Gly Thr Ala Asn 
1               5               


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (3) (DNA)

<400>  20
atccctatcc ttggtaccgc a                                                 21


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (1)

<400>  21

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn 
1               5                   10  


<210>  22
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (1) (DNA)

<400>  22
gggatcatcc ctatctttgg tacagca                                           27


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (2)

<400>  23

Ala Ile Ile Pro Ile Leu Gly Ile Ala Asn 
1               5                   10  


<210>  24
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (2) (DNA)

<400>  24
gctatcatcc cgatccttgg tatcgca                                           27


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (3)

<400>  25

Val Ile Ile Pro Ile Leu Gly Thr Ala Asn 
1               5                   10  


<210>  26
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (3) (DNA)

<400>  26
gtgatcatcc ctatccttgg taccgca                                           27


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  27

Tyr Cys Ala Arg Leu Tyr Gly Tyr 
1               5               


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR3 (DNA)

<400>  28
tactgtgcga gactgtacgg ttac                                              24


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 (1)

<400>  29

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  30
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 (1) (DNA 1)

<400>  30
cgggcaagtc agggcattag aaatgattta ggc                                    33


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 (2)

<400>  31

Arg Ala Ser Gln Gly Ile Arg Asn Val Leu Gly 
1               5                   10      


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 (2) (DNA 1)

<400>  32
cgggcaagtc agggcattcg taatgtttta ggc                                    33


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 (3)

<400>  33

Arg Ala Ser Gln Ser Ile Arg Asn Val Leu Gly 
1               5                   10      


<210>  34
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 (3) (DNA)

<400>  34
cgggcaagtc agagcattcg taatgtttta ggc                                    33


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (1)

<400>  35

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (1) (DNA)

<400>  36
gctgcatcca gtttgcagag t                                                 21


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (2)

<400>  37

Asp Ser Ser Ser Leu Gln Ser 
1               5           


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (2) (DNA)

<400>  38
gattcgtcca gtttgcagag t                                                 21


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (3)

<400>  39

Asp Ala Tyr Ser Leu Gln Ser 
1               5           


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (3) (DNA)

<400>  40
gatgcttaca gcttgcagag t                                                 21


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (4)

<400>  41

Asp Val Ser Ser Leu Gln Ser 
1               5           


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (4) (DNA)

<400>  42
gatgtgtcca gtttgcagag t                                                 21


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (5)

<400>  43

Asp Ala Ser Ser Leu Gln Ser 
1               5           


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (5) (DNA)

<400>  44
gatgcgtcca gtttgcagag t                                                 21


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (6)

<400>  45

Ala Ala Thr Ser Leu Gln Ser 
1               5           


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (6) (DNA)

<400>  46
gctgctacca gtttgcagag t                                                 21


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  47

Leu Gln Asn Gly Leu Gln Pro Ala Thr 
1               5                   


<210>  48
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 (DNA 1)

<400>  48
ttgcagaatg gtctgcagcc cgcgacg                                           27


<210>  49
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (DNA 2)

<400>  49
agctatgcta taagc                                                        15


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (DNA 2)

<400>  50
ggaggcacat tcagcagcta t                                                 21


<210>  51
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (DNA 2)

<400>  51
ggaggcacat tcagcagcta tgctataagc                                        30


<210>  52
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 (1) (DNA 2)

<400>  52
cgggcaagtc aggggattcg taatgattta ggc                                    33


<210>  53
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 (2) (DNA 2)

<400>  53
cgggcaagtc aggggattcg taatgtttta ggc                                    33


<210>  54
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 (DNA 2)

<400>  54
ctgcagaatg gtctgcagcc cgcgacg                                           27


<210>  55
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10; VL

<400>  55

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  56
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10; VL

<400>  56
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaga aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  57
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10(GS); VL

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  58
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10(GS); VL

<400>  58
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaga aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  59
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10; VH

<400>  59

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  60
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10; VH

<400>  60
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_C3B6; VL

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  62
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_C3B6; VL

<400>  62
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaga aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  63
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_C3B6; VH

<400>  63

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  64
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_C3B6; VH

<400>  64
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggagct atcatcccga tccttggtat cgcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_6A12; VL

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  66
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_6A12; VL

<400>  66
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattaga aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcagtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  67
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_6A12; VH

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  68
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_6A12; VH

<400>  68
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctatgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggagtg atcatcccta tccttggtac cgcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_C3A6; VL

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Val 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Ser Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  70
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_C3A6; VL

<400>  70
gacatccaga tgacccagtc tccttcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattcgt aatgttttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat tcgtccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  71
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_C3A6; VH

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  72
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_C3A6; VH

<400>  72
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  73
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_wt; VL

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Val 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Ala Tyr Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  74
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_wt; VL

<400>  74
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca ggggattcgt aatgttttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat gcttacagct tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  75
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_wt; VH

<400>  75

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  76
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_wt; VH

<400>  76
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  77
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_VD; VL

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Ala Tyr Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  78
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_VD; VL

<400>  78
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca ggggattcgt aatgatttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat gcttacagct tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  79
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_VD; VH

<400>  79

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  80
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_D1A2_VD; VH

<400>  80
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  81
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_O7D8; VL

<400>  81

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Asn Val 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Val Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  82
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_O7D8; VL

<400>  82
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gagcattcgt aatgttttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat gtgtccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  83
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_O7D8; VH

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  84
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_O7D8; VH

<400>  84
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  85
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_O1F7; VL

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Val 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  86
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_O1F7; VL

<400>  86
gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattcgt aatgttttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatctatgat gcgtccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcctgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  87
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_O1F7; VH

<400>  87

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  88
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_O1F7; VH

<400>  88
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  89
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_6H10; VL

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Val 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Gln Ala Ala Thr Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Gly Leu Gln Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  90
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_6H10; VL

<400>  90
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga ccgggtcacc       60

atcacctgcc gggcaagtca gggcattcgt aatgttttag gctggtacca gcagaagcca      120

gggaaagccc ctaagcgcct gatccaggct gctaccagtt tgcagagtgg cgtcccatca      180

aggttcagcg gcggtggatc cgggacagag ttcactctca ccatcagcag cttgcagcct      240

gaagattttg ccacctatta ctgcttgcag aatggtctgc agcccgcgac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  91
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10_6H10; VH

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Tyr Ala Tyr Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  92
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B10_6H10; VH

<400>  92
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactgtac      300

ggttacgctt actacggtgc ttttgactac tggggccaag ggaccaccgt gaccgtctcc      360

tca                                                                    363


<210>  93
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  93

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  94
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  94
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  95
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  95

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  96
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  96
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  97
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TNC-A2 avi-tag  his6-tag

<400>  97

Ala Ser Thr Gly Glu Thr Pro Asn Leu Gly Glu Val Val Val Ala Glu 
1               5                   10                  15      


Val Gly Trp Asp Ala Leu Lys Leu Asn Trp Thr Ala Pro Glu Gly Ala 
            20                  25                  30          


Tyr Glu Tyr Phe Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala 
        35                  40                  45              


Ala Gln Asn Leu Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro 
    50                  55                  60                  


Gly Leu Lys Ala Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr 
65                  70                  75                  80  


Gln Asp Phe Ser Thr Thr Pro Leu Ser Val Glu Val Leu Thr Ala Ser 
                85                  90                  95      


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly 
            100                 105                 110         


Thr His His His His His His 
        115                 


<210>  98
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human TNC-A2 avi-tag  his6-tag

<400>  98
gcgtccaccg gggaaacccc gaacctgggc gaagtggtgg tggcggaagt gggttgggat       60

gcgctgaaac tgaactggac cgcgccggaa ggcgcgtatg aatatttttt catccaggtg      120

caggaagcgg ataccgttga agcggcgcag aacctgaccg ttccgggcgg tctgcgtagc      180

accgatctgc cgggcctgaa agcggcgacc cattatacca ttaccatccg tggggtgacc      240

caggatttta gcaccacccc gctgtctgtg gaagtgctga ccgctagcgg cctgaacgac      300

atcttcgagg ctcagaaaat cgaatggcac gaaggtaccc atcaccatca ccaccac         357


<210>  99
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNC Fn5 huA1A2 huA3 avi his biotin from E. coli= pETR7477

<400>  99

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln 
385                 390                 395                 400 


Ala Tyr Glu His Phe Ile Ile Gln Val Gln Glu Ala Asn Lys Val Glu 
                405                 410                 415     


Ala Ala Arg Asn Leu Thr Val Pro Gly Ser Leu Arg Ala Val Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly 
    450                 455                 460                 


Glu Thr Pro Asn Leu Gly Glu Val Val Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Lys Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Glu Tyr Phe 
                485                 490                 495     


Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser 
    530                 535                 540                 


Thr Thr Pro Leu Ser Val Glu Val Leu Thr Glu Glu Val Pro Asp Met 
545                 550                 555                 560 


Gly Asn Leu Thr Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn 
                565                 570                 575     


Trp Thr Thr Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln 
            580                 585                 590         


Glu Ala Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr 
    610                 615                 620                 


Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu Ala 
625                 630                 635                 640 


Val Glu Val Val Thr Ala Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln 
                645                 650                 655     


Lys Ile Glu Trp His Glu Gly Thr His His His His His His 
            660                 665                 670 


<210>  100
<211>  2013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNC Fn5 huA1A2 huA3 avi his biotin from E. coli= pETR7477 (DNA)

<400>  100
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ggttcaacta gtggttctgg tcatcaccat caccatcact ccgcgggtct ggtgccacgc      720

ggtagtactg caattggtat gaaagaaacc gctgctgcta aattcgaacg ccagcacatg      780

gacagcccag atctgggtac cggtggtggc tccggtattg agggacgcgg gtccatggga      840

tatcggggat ccgagctgga cacccccaag gacctgcagg tgtccgagac agccgagaca      900

agcctgaccc tgctgtggaa aacccccctg gccaagttcg accggtacag actgaactac      960

agcctgccca ctggacagtg ggtcggcgtg cagctgcccc ggaacaccac ctcctacgtg     1020

ctgcggggcc tggaacccgg ccaggaatac aacgtcctgc tgacggccga gaagggccgg     1080

cacaagagca agcccgccag agtgaaggcc agcaccgagc aggcccccga gctggaaaac     1140

ctgaccgtga ccgaagtggg ctgggacggc ctgcggctga actggaccgc ggctgaccag     1200

gcctatgagc actttatcat tcaggtgcag gaggccaaca aggtggaggc agctcggaac     1260

ctcaccgtgc ctggcagcct tcgggctgtg gacataccgg gcctcaaggc tgctacgcct     1320

tatacagtct ccatctatgg ggtgatccag ggctatagaa caccagtgct ctctgctgag     1380

gcctccacag gcgaaacacc gaacctgggc gaagtggtgg tggcggaagt gggttgggat     1440

gcgctgaaac tgaactggac cgcgccggaa ggcgcgtatg aatatttttt catccaggtg     1500

caggaagcgg ataccgttga agcggcgcag aacctgaccg ttccgggcgg tctgcgtagc     1560

accgatctgc cgggcctgaa agcggcgacc cattatacca ttaccatccg tggggtgacc     1620

caggacttct ctaccacccc tctgagcgtg gaggtgctga ccgaggaggt acccgacatg     1680

ggcaacctga ccgtgaccga ggtgtcctgg gacgccctgc ggctgaactg gaccaccccc     1740

gacggcacct acgaccagtt cacaatccag gtgcaggaag ccgaccaggt cgaagaggcc     1800

cacaatctga cagtgccagg cagcctgcgg agcatggaaa tccccggcct gagagccggc     1860

accccctaca ccgtgaccct gcacggcgaa gtgcggggcc acagcaccag acccctggcc     1920

gtggaagtgg tcacagctag cggcctgaac gacatcttcg aggctcagaa aatcgaatgg     1980

cacgaaggta cccatcacca tcaccaccac taa                                  2013


<210>  101
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNC Fn5 cyA1A2 huA3 avi his biotin from E. coli  = pETR7478

<400>  101

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln 
385                 390                 395                 400 


Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu Ala Asn Lys Val Glu 
                405                 410                 415     


Ala Ala Gln Asn Leu Thr Val Pro Gly Asn Leu Arg Ala Val Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly 
    450                 455                 460                 


Glu Thr Pro Asn Leu Gly Glu Val Met Val Ser Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Lys Leu Asn Trp Thr Val Pro Glu Gly Ala Tyr Glu Tyr Phe 
                485                 490                 495     


Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn His 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser 
    530                 535                 540                 


Thr Thr Pro Leu Ser Val Glu Val Leu Thr Glu Glu Val Pro Asp Met 
545                 550                 555                 560 


Gly Asn Leu Thr Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn 
                565                 570                 575     


Trp Thr Thr Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln 
            580                 585                 590         


Glu Ala Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr 
    610                 615                 620                 


Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu Ala 
625                 630                 635                 640 


Val Glu Val Val Thr Ala Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln 
                645                 650                 655     


Lys Ile Glu Trp His Glu Gly Thr His His His His His His 
            660                 665                 670 


<210>  102
<211>  2013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNC Fn5 cyA1A2 huA3 avi his biotin from E. coli  = pETR7478 (DNA)

<400>  102
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ggttcaacta gtggttctgg tcatcaccat caccatcact ccgcgggtct ggtgccacgc      720

ggtagtactg caattggtat gaaagaaacc gctgctgcta aattcgaacg ccagcacatg      780

gacagcccag atctgggtac cggtggtggc tccggtattg agggacgcgg gtccatggga      840

tatcggggat ccgagctgga cacccccaag gacctgcagg tgtccgagac agccgagaca      900

agcctgaccc tgctgtggaa aacccccctg gccaagttcg accggtacag actgaactac      960

agcctgccca ctggacagtg ggtcggcgtg cagctgcccc ggaacaccac ctcctacgtg     1020

ctgcggggcc tggaacccgg ccaggaatac aacgtcctgc tgacggccga gaagggcaga     1080

cacaagagca agcccgccag agtgaaggcc agcaccgagc aggcccccga gctggaaaac     1140

ctgaccgtga ccgaagtggg ctgggacggc ctgagactga actggacagc cgccgaccag     1200

gcttatgagc acttcgtgat ccaggtgcag gaagccaaca aggtcgaggc cgcccagaat     1260

ctgaccgtgc ccggcaacct gagagccgtg gacatccctg gcctgaaggc tgccaccccc     1320

tacaccgtgt ccatctacgg cgtgattcag ggctaccgga cccctgtgct gtctgccgag     1380

gccagcacag gcgagacacc caacctgggc gaagtgatgg tgtctgaagt gggatgggat     1440

gccctgaagc tcaattggac cgtgcctgag ggcgcctacg agtacttctt tattcaggtc     1500

caggaagctg acaccgtcga agccgctcag aaccacacag tgcctggcgg cctgagaagc     1560

accgatctgc ccggcctgaa agccgctaca cactacacaa tcaccatcag aggcgtgacc     1620

caggacttca gcaccacccc cctgagcgtg gaggtgctga ccgaagaggt acccgacatg     1680

ggcaacctga ccgtgaccga ggtgtcctgg gacgccctgc ggctgaactg gaccaccccc     1740

gacggcacct acgaccagtt cacaatccag gtgcaggaag ccgaccaggt cgaagaggcc     1800

cacaatctga cagtgccagg cagcctgcgg agcatggaaa tccccggcct gagagccggc     1860

accccctaca ccgtgaccct gcacggcgaa gtgcggggcc acagcaccag acccctggcc     1920

gtggaagtgg tcacagctag cggcctgaac gacatcttcg aggctcagaa aatcgaatgg     1980

cacgaaggta cccatcacca tcaccaccac taa                                  2013


<210>  103
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNC Fn5 muA1A2 huA3 avi his biotin from E. coli  = pETR7479

<400>  103

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Glu Val Pro Ser Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Ala Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Asp Asp Leu 
385                 390                 395                 400 


Ala Tyr Glu Tyr Phe Val Ile Gln Val Gln Glu Ala Asn Asn Val Glu 
                405                 410                 415     


Thr Ala His Asn Phe Thr Val Pro Gly Asn Leu Arg Ala Ala Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Val Ala Thr Ser Tyr Arg Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ala Arg Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Thr Ser Thr Gly 
    450                 455                 460                 


Thr Thr Pro Asn Leu Gly Glu Val Thr Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Thr Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Lys Asn Phe 
                485                 490                 495     


Phe Ile Gln Val Leu Glu Ala Asp Thr Thr Gln Thr Val Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Val Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr Arg Tyr Tyr Ile Thr Leu Arg Gly Val Thr Gln Asp Phe Gly 
    530                 535                 540                 


Thr Ala Pro Leu Ser Val Glu Val Leu Thr Glu Glu Val Pro Asp Met 
545                 550                 555                 560 


Gly Asn Leu Thr Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn 
                565                 570                 575     


Trp Thr Thr Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln 
            580                 585                 590         


Glu Ala Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr 
    610                 615                 620                 


Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu Ala 
625                 630                 635                 640 


Val Glu Val Val Thr Ala Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln 
                645                 650                 655     


Lys Ile Glu Trp His Glu Gly Thr His His His His His His 
            660                 665                 670 


<210>  104
<211>  2013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNC Fn5 muA1A2 huA3 avi his biotin from E. coli  = pETR7479 (DNA)

<400>  104
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ggttcaacta gtggttctgg tcatcaccat caccatcact ccgcgggtct ggtgccacgc      720

ggtagtactg caattggtat gaaagaaacc gctgctgcta aattcgaacg ccagcacatg      780

gacagcccag atctgggtac cggtggtggc tccggtattg agggacgcgg gtccatggga      840

tatcggggat ccgagctgga cacccccaag gacctgcagg tgtccgagac agccgagaca      900

agcctgaccc tgctgtggaa aacccccctg gccaagttcg accggtacag actgaactac      960

agcctgccca ctggacagtg ggtcggcgtg cagctgcccc ggaacaccac ctcctacgtg     1020

ctgcggggcc tggaacccgg ccaggaatac aacgtcctgc tgacggccga gaagggccgg     1080

cacaagagca agcccgccag agtgaaggcc agcaccgagg aagtgcccag cctggaaaac     1140

ctgaccgtga ccgaggccgg ctgggacggc ctgcggctga actggaccgc cgacgacctg     1200

gcctacgagt acttcgtgat ccaggtgcag gaagccaaca acgtcgagac agcccacaac     1260

ttcaccgtgc ccggcaacct gagagccgcc gacatccccg gcctgaaggt ggccacatcc     1320

taccgggtgt ccatctacgg cgtggccagg ggctaccgga cccccgtgct gtccgccgag     1380

acaagcaccg gcaccacgcc gaacctgggc gaagtgaccg tggcggaagt gggttgggat     1440

gcgctgaccc tgaattggac cgcaccggaa ggcgcgtata aaaacttttt catccaggtg     1500

ctggaagcgg ataccaccca gaccgtgcag aacctgaccg tgccgggtgg tctgcgtagc     1560

gtggatctgc cgggcctgaa agcggcgacc cgttattaca ttaccctgcg tggcgtgacc     1620

caggattttg gcaccgcgcc gctgtctgtg gaagtgctga ccgaggaggt acccgacatg     1680

ggcaacctga ccgtgaccga ggtgtcctgg gacgccctgc ggctgaactg gaccaccccc     1740

gacggcacct acgaccagtt cacaatccag gtgcaggaag ccgaccaggt cgaagaggcc     1800

cacaatctga cagtgccagg cagcctgcgg agcatggaaa tccccggcct gagagccggc     1860

accccctaca ccgtgaccct gcacggcgaa gtgcggggcc acagcaccag acccctggcc     1920

gtggaagtgg tcacagctag cggcctgaac gacatcttcg aggctcagaa aatcgaatgg     1980

cacgaaggta cccatcacca tcaccaccac taa                                  2013


<210>  105
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEK human TNC 1-8

<400>  105

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Ser Pro Pro Lys Asp Leu Val Val Thr Glu Val 
            20                  25                  30          


Thr Glu Glu Thr Val Asn Leu Ala Trp Asp Asn Glu Met Arg Val Thr 
        35                  40                  45              


Glu Tyr Leu Val Val Tyr Thr Pro Thr His Glu Gly Gly Leu Glu Met 
    50                  55                  60                  


Gln Phe Arg Val Pro Gly Asp Gln Thr Ser Thr Ile Ile Arg Glu Leu 
65                  70                  75                  80  


Glu Pro Gly Val Glu Tyr Phe Ile Arg Val Phe Ala Ile Leu Glu Asn 
                85                  90                  95      


Lys Lys Ser Ile Pro Val Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala 
            100                 105                 110         


Pro Glu Gly Leu Lys Phe Lys Ser Ile Lys Glu Thr Ser Val Glu Val 
        115                 120                 125             


Glu Trp Asp Pro Leu Asp Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe 
    130                 135                 140                 


Arg Asn Met Asn Lys Glu Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg 
145                 150                 155                 160 


Arg Pro Glu Thr Ser Tyr Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu 
                165                 170                 175     


Tyr Glu Ile Ser Leu His Ile Val Lys Asn Asn Thr Arg Gly Pro Gly 
            180                 185                 190         


Leu Lys Arg Val Thr Thr Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu 
        195                 200                 205             


Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro 
    210                 215                 220                 


Leu Ala Glu Ile Asp Gly Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val 
225                 230                 235                 240 


Pro Gly Asp Arg Thr Thr Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr 
                245                 250                 255     


Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile 
            260                 265                 270         


Ser Arg Arg Gly Asp Met Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr 
        275                 280                 285             


Thr Gly Leu Asp Ala Pro Arg Asn Leu Arg Arg Val Ser Gln Thr Asp 
    290                 295                 300                 


Asn Ser Ile Thr Leu Glu Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser 
305                 310                 315                 320 


Tyr Arg Ile Lys Tyr Ala Pro Ile Ser Gly Gly Asp His Ala Glu Val 
                325                 330                 335     


Asp Val Pro Lys Ser Gln Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly 
            340                 345                 350         


Leu Arg Pro Gly Thr Glu Tyr Gly Ile Gly Val Ser Ala Val Lys Glu 
        355                 360                 365             


Asp Lys Glu Ser Asn Pro Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp 
    370                 375                 380                 


Thr Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr 
385                 390                 395                 400 


Leu Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn 
                405                 410                 415     


Tyr Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn 
            420                 425                 430         


Thr Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn 
        435                 440                 445             


Val Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg 
    450                 455                 460                 


Val Lys Ala Ser Thr Glu Gln Ala Ala Met Gly Ser Pro Lys Glu Val 
465                 470                 475                 480 


Ile Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val Ser Trp Arg Ala 
                485                 490                 495     


Pro Thr Ala Gln Val Glu Ser Phe Arg Ile Thr Tyr Val Pro Ile Thr 
            500                 505                 510         


Gly Gly Thr Pro Ser Met Val Thr Val Asp Gly Thr Lys Thr Gln Thr 
        515                 520                 525             


Arg Leu Val Lys Leu Ile Pro Gly Val Glu Tyr Leu Val Ser Ile Ile 
    530                 535                 540                 


Ala Met Lys Gly Phe Glu Glu Ser Glu Pro Val Ser Gly Ser Phe Thr 
545                 550                 555                 560 


Thr Ala Leu Asp Gly Pro Ser Gly Leu Val Thr Ala Asn Ile Thr Asp 
                565                 570                 575     


Ser Glu Ala Leu Ala Arg Trp Gln Pro Ala Ile Ala Thr Val Asp Ser 
            580                 585                 590         


Tyr Val Ile Ser Tyr Thr Gly Glu Lys Val Pro Glu Ile Thr Arg Thr 
        595                 600                 605             


Val Ser Gly Asn Thr Val Glu Tyr Ala Leu Thr Asp Leu Glu Pro Ala 
    610                 615                 620                 


Thr Glu Tyr Thr Leu Arg Ile Phe Ala Glu Lys Gly Pro Gln Lys Ser 
625                 630                 635                 640 


Ser Thr Ile Thr Ala Lys Phe Thr Thr Asp Leu Asp Ser Pro Arg Asp 
                645                 650                 655     


Leu Thr Ala Thr Glu Val Gln Ser Glu Thr Ala Leu Leu Thr Trp Arg 
            660                 665                 670         


Pro Pro Arg Ala Ser Val Thr Gly Tyr Leu Leu Val Tyr Glu Ser Val 
        675                 680                 685             


Asp Gly Thr Val Lys Glu Val Ile Val Gly Pro Asp Thr Thr Ser Tyr 
    690                 695                 700                 


Ser Leu Ala Asp Leu Ser Pro Ser Thr His Tyr Thr Ala Lys Ile Gln 
705                 710                 715                 720 


Ala Leu Asn Gly Pro Leu Arg Ser Asn Met Ile Gln Thr Ile Phe Thr 
                725                 730                 735     


Thr Val Asp Leu Glu Val Leu Phe Gln Gly Pro Gly Ser Gly Leu Asn 
            740                 745                 750         


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Ala Arg Ala His 
        755                 760                 765             


His His His His His 
    770             


<210>  106
<211>  2322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK human TNC 1-8 (DNA)

<400>  106
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

gtgtctcctc ccaaagacct cgttgtgaca gaagtgacgg aagagacggt caacctggcc      120

tgggacaatg agatgcgggt cacagagtac cttgtcgtgt acacgcccac ccacgagggt      180

ggtctggaaa tgcagttccg tgtgcctggg gaccagacgt ccaccatcat ccgggagctg      240

gagcctggtg tggagtactt tatccgtgta tttgccatcc tggagaacaa gaagagcatt      300

cctgtcagcg ccagggtggc cacgtactta cctgcacctg aaggcctgaa attcaagtcc      360

atcaaggaga catctgtgga agtggagtgg gatcctctag acattgcttt tgaaacctgg      420

gagatcatct tccggaatat gaataaagaa gatgagggag agatcaccaa aagcctgagg      480

aggccagaga cctcttaccg gcaaactggt ctagctcctg ggcaagagta tgagatatct      540

ctgcacatag tgaaaaacaa tacccggggc cctggcctga agagggtgac caccacacgc      600

ttggatgccc ccagccagat cgaggtgaaa gatgtcacag acaccactgc cttgatcacc      660

tggttcaagc ccctggctga gatcgatggc attgagctga cctacggcat caaagacgtg      720

ccaggagacc gtaccaccat cgatctcaca gaggacgaga accagtactc catcgggaac      780

ctgaagcctg acactgagta cgaggtgtcc ctcatctccc gcagaggtga catgtcaagc      840

aacccagcca aagagacctt cacaacaggc ctcgatgctc ccaggaatct tcgacgtgtt      900

tcccagacag ataacagcat caccctggaa tggaggaatg gcaaggcagc tattgacagt      960

tacagaatta agtatgcccc catctctgga ggggaccacg ctgaggttga tgttccaaag     1020

agccaacaag ccacaaccaa aaccacactc acaggtctga ggccgggaac tgaatatggg     1080

attggagttt ctgctgtgaa ggaagacaag gagagcaatc cagcgaccat caacgcagcc     1140

acagagttgg acacgcccaa ggaccttcag gtttctgaaa ctgcagagac cagcctgacc     1200

ctgctctgga agacaccgtt ggccaaattt gaccgctacc gcctcaatta cagtctcccc     1260

acaggccagt gggtgggagt gcagcttcca agaaacacca cttcctatgt cctgagaggc     1320

ctggaaccag gacaggagta caatgtcctc ctgacagccg agaaaggcag acacaagagc     1380

aagcccgcac gtgtgaaggc atccactgaa caagccgcca tgggctcccc aaaggaagtc     1440

attttctcag acatcactga aaattcggct actgtcagct ggagggcacc cacagcccaa     1500

gtggagagct tccggattac ctatgtgccc attacaggag gtacaccctc catggtaact     1560

gtggacggaa ccaagactca gaccaggctg gtgaaactca tacctggcgt ggagtacctt     1620

gtcagcatca tcgccatgaa gggctttgag gaaagtgaac ctgtctcagg gtcattcacc     1680

acagctctgg atggcccatc tggcctggtg acagccaaca tcactgactc agaagccttg     1740

gccaggtggc agccagccat tgccactgtg gacagttatg tcatctccta cacaggcgag     1800

aaagtgccag aaattacacg cacggtgtcc gggaacacag tggagtatgc tctgaccgac     1860

ctcgagcctg ccacggaata cacactgaga atctttgcag agaaagggcc ccagaagagc     1920

tcaaccatca ctgccaagtt cacaacagac ctcgattctc caagagactt gactgctact     1980

gaggttcagt cggaaactgc cctccttacc tggcgacccc cccgggcatc agtcaccggt     2040

tacctgctgg tctatgaatc agtggatggc acagtcaagg aagtcattgt gggtccagat     2100

accacctcct acagcctggc agacctgagc ccatccaccc actacacagc caagatccag     2160

gcactcaatg ggcccctgag gagcaatatg atccagacca tcttcaccac agtcgacctg     2220

gaagttctgt tccaggggcc cggctcaggc ctgaacgaca tcttcgaggc ccagaagatc     2280

gagtggcacg aggctcgagc tcaccaccat caccatcact ga                        2322


<210>  107
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 1

<400>  107

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  108
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 1 (DNA1)

<400>  108
atggactgga cctggagaat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  109
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 1 (DNA 2)

<400>  109
atggactgga cctggaggat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  110
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 2

<400>  110

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys 
            20          


<210>  111
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 2 (DNA)

<400>  111
atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt cccaggtgcc       60

aggtgt                                                                  66


<210>  112
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 3

<400>  112

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  113
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 3 (DNA 1)

<400>  113
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcc          57


<210>  114
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 3 (DNA 1)

<400>  114
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccactggagt gcattcc          57


<210>  115
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 3 (DNA 3)

<400>  115
atgggctggt cctgcatcat cctgtttctg gtcgccacag ccaccggcgt gcactct          57


<210>  116
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMB3

<400>  116
caggaaacag ctatgaccat gattac                                            26


<210>  117
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LibL1b_new


<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is a, c, g, or t

<400>  117
cactttggtc ccctggccga acgtmnnggg mnnmnnmnna ccctgctgac agtaatacac       60

tgc                                                                     63


<210>  118
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS63

<400>  118
tttcgcacag taatatacgg ccgtgtcc                                          28


<210>  119
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS64

<400>  119
acgttcggcc aggggaccaa agtgg                                             25


<210>  120
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lib2H


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<400>  120
ggccgtatat tactgtgcga aannknnknn knnknnkttt gactactggg gccaaggaac       60


<210>  121
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fdseqlong

<400>  121
gacgttagta aatgaatttt ctgtatgagg                                        30


<210>  122
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH_LIB3


<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  n is a, c, g, or t

<400>  122
gactttggtg ccctggccaa acgtmnnggg mnnmnnaccm nnctgcaagc agtaataggt       60

ggcaaaatc                                                               69


<210>  123
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH31

<400>  123
acgtttggcc agggcaccaa agtcgag                                           27


<210>  124
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH32

<400>  124
tctcgcacag taatacacgg cggtgtcc                                          28


<210>  125
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIB88_2


<220>
<221>  misc_difference
<222>  (29)..(55)
<223>  (33% GAC Asp; 26% GGT Gly; 10% GAA Glu; 9% CGT Arg; 7% Lys; 6% 
       GTT Val; 5% TCT Ser; 4% CTG Leu)1 - (23% GGT Gly; 17% TAC Tyr; 
       16% TCT Ser; 11% GCT Ala; 9% CGT Arg; 7% AAC Asn; 6% ACT Thr; 6% 
       GTT Val; 5% CCG Pro)8

<220>
<221>  misc_feature
<222>  (30)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  n is a, c, g, or t

<400>  125
ggacaccgcc gtgtattact gtgcgagabn nnnbnnbnnb nnbnnbnnbn nbnnbtttga       60

ctactggggc caagggacca ccgtgaccgt ctcc                                   94


<210>  126
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AM_Vk1A30_L1_ba

<400>  126
cctggcttct gctggtacca gcctaaatca ttacgaatgc cctgacttgc ccggcaggtg       60

atg                                                                     63


<210>  127
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH50(Vk1A30_L1/L2_fo)

<400>  127
gctggtacca gcagaagcca gggaaag                                           27


<210>  128
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH51(Vk1A30_BsiWI_ba)

<400>  128
ggtgcagcca ccgtacgctt gatctc                                            26


<210>  129
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AM_Vk1A30_L2_ba

<400>  129
cttgatggga cgccactctg caaactggac gcagcataga tcaggcgctt aggggctttc       60

c                                                                       61


<210>  130
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH52(Vk1A30_L2/L3)

<400>  130
ttgcagagtg gcgtcccatc aaggttc                                           27


<210>  131
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH53

<400>  131
catcagggcc tgagctcgcc cgtcac                                            26


<210>  132
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AM_DP88_H1_ba_opt

<400>  132
gtccaggggc ctgtcgcacc cagcttatag cgtagctgct gaatgtgcct ccggaggcct       60

tg                                                                      62


<210>  133
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH54(DP88_H1/H2_fo)

<400>  133
ataagctggg tgcgacaggc ccctggac                                          28


<210>  134
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS52

<400>  134
gaagaccgat gggcctttgg tgctag                                            26


<210>  135
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AM_DP88_H2_ba

<400>  135
gaccctgccc tggaacttct gtgcgtagtt tgcggtacca aagataggga tgatccctcc       60

catccactcg agcccttgtc cag                                               83


<210>  136
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH55 (DP88_H2H3_fo)

<400>  136
tacgcacaga agttccaggg cagggtcac                                         29


