                         SEQUENCE LISTING

<110>  Roche Glycart AG
 
<120>  Anti-FAP Antibodies and Methods of Use

<130>  26953

<160>  352   

<170>  PatentIn version 3.5

<210>  1
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Library Template for DP47-3 library

<400>  1
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggccgaaa tcgtgttaac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga      120

gccaccctct cttgcagggc cagtcagagt gttagcagca gctacttagc ctggtaccag      180

cagaaacctg gccaggctcc caggctcctc atctatggag catccagcag ggccactggc      240

atcccagaca ggttcagtgg cagtggatcc gggacagact tcactctcac catcagcaga      300

ctggagcctg aagattttgc agtgtattac tgtcagcagt atggtagctc accgctgacg      360

ttcggccagg ggaccaaagt ggaaatcaaa cgtacggtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg tggagccgca      720

gaacaaaaac tcatctcaga agaggatctg aatggagccg cagactacaa ggacgacgac      780

gacaagggtg ccgcataata aggcgcgcca attctatttc aaggagacag tcatatgaaa      840

tacctgctgc cgaccgctgc tgctggtctg ctgctcctcg ctgcccagcc ggcgatggcc      900

gaggtgcaat tgctggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      960

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct     1020

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac     1080

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat     1140

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaccgttt     1200

ccgtattttg actactgggg ccaaggaacc ctggtcaccg tctcgagtgc tagcaccaaa     1260

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc     1320

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc     1380

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc     1440

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac     1500

gtgaatcaca agcccagcaa caccaaagtg gacaagaaag ttgagcccaa atcttgtgac     1560

gcggccgcaa gcactagtgc ccatcaccat caccatcacg ccgcggcata g              1611


<210>  2
<211>  1617
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Library Template for DP88-3 library

<400>  2
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggccgata tccagatgac ccagtctcca tcctccctgt ctgcatctgt cggagaccgg      120

gtcaccatca cctgccgggc aagtcagggc attagaaatg atttaggctg gtaccagcag      180

aagccaggga aagcccctaa gcgcctgatc tatgctgcat ccagtttgca gagtggcgtc      240

ccatcaaggt tcagcggcag tggatccggg acagagttca ctctcaccat cagcagcttg      300

cagcctgaag attttgccac ctattactgc ttgcagcata atagttaccc cacgtttggc      360

cagggcacca aagtcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagc cgcagaacaa      720

aaactcatct cagaagagga tctgaatgga gccgcagact acaaggacga cgacgacaag      780

ggtgccgcat aataaggcgc gccaattcta tttcaaggag acagtcatat gaaatacctg      840

ctgccgaccg ctgctgctgg tctgctgctc ctcgctgccc agccggcgat ggcccaggtg      900

caattggtgc agtctggggc tgaggtgaag aagcctgggt cctcggtgaa ggtctcctgc      960

aaggcctccg gaggcacatt cagcagctac gctataagct gggtgcgaca ggcccctgga     1020

caagggctcg agtggatggg agggatcatc cctatctttg gtacagcaaa ctacgcacag     1080

aagttccagg gcagggtcac cattactgca gacaaatcca cgagcacagc ctacatggag     1140

ctgagcagcc tgagatctga ggacaccgcc gtgtattact gtgcgagact atccccaggc     1200

ggttactatg ttatggatgc ctggggccaa gggaccaccg tgaccgtctc ctcagctagc     1260

accaaaggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca     1320

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac     1380

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     1440

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     1500

tgcaacgtga atcacaagcc cagcaacacc aaagtggaca agaaagttga gcccaaatct     1560

tgtgacgcgg ccgcaagcac tagtgcccat caccatcacc atcacgccgc ggcatag        1617


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (1)

<400>  3

Ser Tyr Ala Met Ser 
1               5   


<210>  4
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (1) (DNA 1)

<400>  4
agttatgcca tgagc                                                        15


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (2)

<400>  5

Ser Tyr Thr Met Ser 
1               5   


<210>  6
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (2) (DNA)

<400>  6
agttatacca tgagc                                                        15


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (3)

<400>  7

Ser Phe Ala Met Ser 
1               5   


<210>  8
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (3) (DNA)

<400>  8
agttttgcca tgagc                                                        15


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (4)

<400>  9

Ser His Ala Met Ser 
1               5   


<210>  10
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (4) (DNA)

<400>  10
agtcatgcta tgagc                                                        15


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (5)

<400>  11

Ser Ser Ala Met Ser 
1               5   


<210>  12
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (5) (DNA)

<400>  12
agttctgcca tgagc                                                        15


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (1)

<400>  13

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (1) (DNA)

<400>  14
ggattcacct ttagcagtta t                                                 21


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (2)

<400>  15

Gly Ser Thr Phe Ser Ser Tyr 
1               5           


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (2) (DNA)

<400>  16
ggatccacct ttagcagtta t                                                 21


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (3)

<400>  17

Gly Phe Thr Phe Ser Ser Phe 
1               5           


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (3) (DNA)

<400>  18
ggattcacct ttagcagttt t                                                 21


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (4)

<400>  19

Gly Phe Thr Phe Ser Ser His 
1               5           


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (4) (DNA)

<400>  20
ggattcacct ttagcagtca t                                                 21


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (5)

<400>  21

Gly Phe Thr Phe Ser Ser Ser 
1               5           


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia (5) (DNA)

<400>  22
ggattcacct ttagcagttc t                                                 21


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (1)

<400>  23

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  24
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (1) (DNA 1)

<400>  24
ggattcacct ttagcagtta tgccatgagc                                        30


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (2)

<400>  25

Gly Ser Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  26
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (2) (DNA)

<400>  26
ggatccacct ttagcagtta tgccatgagc                                        30


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (3)

<400>  27

Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser 
1               5                   10  


<210>  28
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (3) (DNA)

<400>  28
ggattcacct ttagcagtta taccatgagc                                        30


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (4)

<400>  29

Gly Phe Thr Phe Ser Ser Phe Ala Met Ser 
1               5                   10  


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (4) (DNA)

<400>  30
ggattcacct ttagcagttt tgccatgagc                                        30


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (5)

<400>  31

Gly Phe Thr Phe Ser Ser His Ala Met Ser 
1               5                   10  


<210>  32
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (5) (DNA)

<400>  32
ggattcacct ttagcagtca tgctatgagc                                        30


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (6)

<400>  33

Gly Phe Thr Phe Ser Ser Ser Ala Met Ser 
1               5                   10  


<210>  34
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (6) (DNA)

<400>  34
ggattcacct ttagcagttc tgccatgagc                                        30


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (1)

<400>  35

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  36
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (1) (DNA 1)

<400>  36
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaag                    48


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (2)

<400>  37

Ala Ile Gly Val Ser Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  38
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (2) (DNA)

<400>  38
gctattggtg ttagtactgg tagcacatac tacgcagact ccgtgaag                    48


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (3)

<400>  39

Ala Ile Ser Gly Ser Ala Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  40
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (3) (DNA)

<400>  40
gctattagtg ggagtgctgg ttatacatac tacgcagact ccgtgaag                    48


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (4)

<400>  41

Ala Ile Ser Gly Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15  


<210>  42
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (4) (DNA)

<400>  42
gctattagtg gtggtggtag gacatactac gcagactccg tgaag                       45


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (5)

<400>  43

Ala Ile Ile Ser Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  44
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (5) (DNA)

<400>  44
gcgattatta gtagtggtgg tctcacatac tacgcagact ccgtgaag                    48


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (6)

<400>  45

Ala Ile Ile Gly Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  46
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (6) (DNA)

<400>  46
gctattattg ggagtggtag tcgtacatac tacgcagact ccgtgaag                    48


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (7)

<400>  47

Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  48
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (7) (DNA)

<400>  48
gctattattg gtagtggtgc tagcacatac tacgcagact ccgtgaag                    48


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (8)

<400>  49

Ala Ile Trp Gly Gly Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  50
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (8) (DNA)

<400>  50
gctatttggg gtggtggtcg tagcacatac tacgcagact ccgtgaag                    48


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (9)

<400>  51

Ala Ile Ile Ser Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  52
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (9) (DNA)

<400>  52
gctattatta gtagtggggc tagcacatac tacgcagact ccgtgaag                    48


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (10)

<400>  53

Ala Ile Leu Ala Ser Gly Ala Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  54
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (10) (DNA)

<400>  54
gctattttgg ctagtggtgc gatcacatac tacgcagact ccgtgaag                    48


<210>  55
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (11)

<400>  55

Gly Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  56
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (11) (DNA)

<400>  56
ggtattattg gtagtggtgg tatcacatac tacgcagact ccgtgaag                    48


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (12)

<400>  57

Ala Ile Leu Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  58
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (12) (DNA)

<400>  58
gctattcttg gtagtggtgg tagcacatac tacgcagact ccgtgaag                    48


<210>  59
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (13)

<400>  59

Ala Ile Ile Gly Ser Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  60
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (13) (DNA)

<400>  60
gctattattg gtagtggtag taacacatac tacgcagact ccgtgaag                    48


<210>  61
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (14)

<400>  61

Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15  


<210>  62
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (14) (DNA)

<400>  62
gctatttggg ctagtgggga gcaatactac gcagactccg tgaag                       45


<210>  63
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (15)

<400>  63

Ala Ile Ile Gly Ser Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  64
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (15) (DNA)

<400>  64
gctattattg gtagtggtag tatcacatac tacgcagact ccgtgaag                    48


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (16)

<400>  65

Ala Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  66
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (16) (DNA)

<400>  66
gctattattg gtagtggtgg tatcacatac tacgcagact ccgtgaag                    48


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (17)

<400>  67

Ala Ile Ser Thr Asn Gly Asn Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  68
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (17) (DNA)

<400>  68
gctattagta ctaatggtaa ttatacatac tacgcagact ccgtgaag                    48


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (1)

<400>  69

Ser Gly Ser Gly Gly Ser Thr 
1               5           


<210>  70
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (1) (DNA 1)

<400>  70
agtggtagtg gtggtagcac a                                                 21


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (2)

<400>  71

Gly Val Ser Thr Gly Ser Thr 
1               5           


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (2) (DNA)

<400>  72
ggtgttagta ctggtagcac a                                                 21


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (3)

<400>  73

Ser Gly Ser Ala Gly Tyr Thr 
1               5           


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (3) (DNA)

<400>  74
agtgggagtg ctggttatac a                                                 21


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (4)

<400>  75

Ser Gly Gly Gly Arg Thr 
1               5       


<210>  76
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (4) (DNA)

<400>  76
agtggtggtg gtaggaca                                                     18


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (5)

<400>  77

Ile Ser Ser Gly Gly Leu Thr 
1               5           


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (5) (DNA)

<400>  78
attagtagtg gtggtctcac a                                                 21


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (6)

<400>  79

Ile Gly Ser Gly Ser Arg Thr 
1               5           


<210>  80
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (6) (DNA)

<400>  80
attgggagtg gtagtcgtac a                                                 21


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (7)

<400>  81

Ile Gly Ser Gly Ala Ser Thr 
1               5           


<210>  82
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (7) (DNA)

<400>  82
attggtagtg gtgctagcac a                                                 21


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (8)

<400>  83

Trp Gly Gly Gly Arg Ser Thr 
1               5           


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (8) (DNA)

<400>  84
attggtagtg gtgctagcac a                                                 21


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (9)

<400>  85

Ile Ser Ser Gly Ala Ser Thr 
1               5           


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (9) (DNA)

<400>  86
attagtagtg gggctagcac a                                                 21


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (10)

<400>  87

Leu Ala Ser Gly Ala Ile Thr 
1               5           


<210>  88
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (10) (DNA)

<400>  88
ttggctagtg gtgcgatcac a                                                 21


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (11)

<400>  89

Ile Gly Ser Gly Gly Ile Thr 
1               5           


<210>  90
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (11) (DNA)

<400>  90
attggtagtg gtggtatcac a                                                 21


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (12)

<400>  91

Leu Gly Ser Gly Gly Ser Thr 
1               5           


<210>  92
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (12) (DNA)

<400>  92
cttggtagtg gtggtagcac a                                                 21


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (13)

<400>  93

Ile Gly Ser Gly Ser Asn Thr 
1               5           


<210>  94
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (13) (DNA)

<400>  94
attggtagtg gtagtaacac a                                                 21


<210>  95
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (14)

<400>  95

Trp Ala Ser Gly Glu Gln 
1               5       


<210>  96
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (14) (DNA)

<400>  96
tgggctagtg gggagcaa                                                     18


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (15)

<400>  97

Ile Gly Ser Gly Ser Ile Thr 
1               5           


<210>  98
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (15) (DNA)

<400>  98
attggtagtg gtagtatcac a                                                 21


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (16)

<400>  99

Ser Thr Asn Gly Asn Tyr Thr 
1               5           


<210>  100
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (16) (DNA)

<400>  100
agtactaatg gtaattatac a                                                 21


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (1)

<400>  101

Ala Ile Ser Gly Ser Gly Gly Ser Thr 
1               5                   


<210>  102
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (1) (DNA 1)

<400>  102
gctattagtg gtagtggtgg tagcaca                                           27


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (2)

<400>  103

Ala Ile Gly Val Ser Thr Gly Ser Thr 
1               5                   


<210>  104
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (2) (DNA)

<400>  104
gctattggtg ttagtactgg tagcaca                                           27


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (3)

<400>  105

Ala Ile Ser Gly Ser Ala Gly Tyr Thr 
1               5                   


<210>  106
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (3) (DNA)

<400>  106
gctattagtg ggagtgctgg ttataca                                           27


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (4)

<400>  107

Ala Ile Ser Gly Gly Gly Arg Thr 
1               5               


<210>  108
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (4) (DNA)

<400>  108
gctattagtg gtggtggtag gaca                                              24


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (5)

<400>  109

Ala Ile Ile Ser Ser Gly Gly Leu Thr 
1               5                   


<210>  110
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (5) (DNA)

<400>  110
gcgattatta gtagtggtgg tctcaca                                           27


<210>  111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (6)

<400>  111

Ala Ile Ile Gly Ser Gly Ser Arg Thr 
1               5                   


<210>  112
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (6) (DNA)

<400>  112
gctattattg ggagtggtag tcgtaca                                           27


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (7)

<400>  113

Ala Ile Ile Gly Ser Gly Ala Ser Thr 
1               5                   


<210>  114
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (7) (DNA)

<400>  114
gctattattg gtagtggtgc tagcaca                                           27


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (8)

<400>  115

Ala Ile Trp Gly Gly Gly Arg Ser Thr 
1               5                   


<210>  116
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (8) (DNA)

<400>  116
gctatttggg gtggtggtcg tagcaca                                           27


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (9)

<400>  117

Ala Ile Ile Ser Ser Gly Ala Ser Thr 
1               5                   


<210>  118
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (9) (DNA)

<400>  118
gctattatta gtagtggggc tagcaca                                           27


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (10)

<400>  119

Ala Ile Leu Ala Ser Gly Ala Ile Thr 
1               5                   


<210>  120
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (10) (DNA)

<400>  120
gctattttgg ctagtggtgc gatcaca                                           27


<210>  121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (11)

<400>  121

Gly Ile Ile Gly Ser Gly Gly Ile Thr 
1               5                   


<210>  122
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (11) (DNA)

<400>  122
ggtattattg gtagtggtgg tatcaca                                           27


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (12)

<400>  123

Ala Ile Leu Gly Ser Gly Gly Ser Thr 
1               5                   


<210>  124
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (12) (DNA)

<400>  124
gctattcttg gtagtggtgg tagcaca                                           27


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (13)

<400>  125

Ala Ile Ile Gly Ser Gly Ser Asn Thr 
1               5                   


<210>  126
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (13) (DNA)

<400>  126
gctattattg gtagtggtag taacaca                                           27


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (14)

<400>  127

Ala Ile Trp Ala Ser Gly Glu Gln 
1               5               


<210>  128
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (14) (DNA)

<400>  128
gctatttggg ctagtgggga gcaa                                              24


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (15)

<400>  129

Ala Ile Ile Gly Ser Gly Ser Ile Thr 
1               5                   


<210>  130
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (15) (DNA)

<400>  130
gctattattg gtagtggtag tatcaca                                           27


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (16)

<400>  131

Ala Ile Ile Gly Ser Gly Gly Ile Thr 
1               5                   


<210>  132
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (16) (DNA)

<400>  132
gctattattg gtagtggtgg tatcaca                                           27


<210>  133
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (17)

<400>  133

Ala Ile Ser Thr Asn Gly Asn Tyr Thr 
1               5                   


<210>  134
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (17) (DNA)

<400>  134
gctattagta ctaatggtaa ttataca                                           27


<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 (1)

<400>  135

Tyr Cys Ala Lys Gly Trp Phe Gly 
1               5               


<210>  136
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR3 (1) (DNA 1)

<400>  136
tactgtgcga aagggtggtt tggt                                              24


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 (2)

<400>  137

Tyr Cys Ala Lys Gly Trp Leu Gly 
1               5               


<210>  138
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR3 (2) (DNA 1)

<400>  138
tactgtgcga aaggttggct gggt                                              24


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 (3)

<400>  139

Tyr Cys Ala Lys Gly Trp Phe Thr 
1               5               


<210>  140
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR3 (3) (DNA)

<400>  140
tactgtgcga aaggttggtt tacg                                              24


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 (4)

<400>  141

Tyr Cys Ala Lys Ala Trp Met Gly 
1               5               


<210>  142
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR3 (4) (DNA)

<400>  142
tactgtgcga aagcttggat gggg                                              24


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 (1)

<400>  143

Arg Ala Ser Gln Ser Val Thr Ser Ser Tyr Leu 
1               5                   10      


<210>  144
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 (1) (DNA)

<400>  144
agggccagtc agagtgttac cagtagctac tta                                    33


<210>  145
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 (2)

<400>  145

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu 
1               5                   10      


<210>  146
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 (2) (DNA)

<400>  146
agggccagtc agagtgttag cagcagctac tta                                    33


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 (3)

<400>  147

Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu 
1               5                   10      


<210>  148
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 (3) (DNA)

<400>  148
agggccagtc agagtgttag ccgcagctac tta                                    33


<210>  149
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 (4)

<400>  149

Arg Ala Ser Gln Ser Val Ser Ser Asn Tyr Leu 
1               5                   10      


<210>  150
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 (4) (DNA 1)

<400>  150
agggccagtc agagtgttag cagcaattac tta                                    33


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (1)

<400>  151

Asn Val Gly Ser Arg Arg Ala 
1               5           


<210>  152
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (1) (DNA)

<400>  152
aatgtgggct cccgtagggc c                                                 21


<210>  153
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (2)

<400>  153

Tyr Gly Ala Ser Ser Arg Ala 
1               5           


<210>  154
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (2) (DNA)

<400>  154
tatggagcat ccagcagggc c                                                 21


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (3)

<400>  155

Ile Gly Ala Ser Thr Arg Ala 
1               5           


<210>  156
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (3) (DNA)

<400>  156
attggggcct ccaccagggc c                                                 21


<210>  157
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (4)

<400>  157

Tyr Gly Ala Tyr Ile Arg Ala 
1               5           


<210>  158
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (4) (DNA)

<400>  158
tatggcgcct acatcagggc c                                                 21


<210>  159
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (5)

<400>  159

Gln Gly Ala Ser Ser Arg Ala 
1               5           


<210>  160
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (5) (DNA)

<400>  160
cagggcgcct ccagcagggc c                                                 21


<210>  161
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 (6)

<400>  161

Tyr Gly Ala Ser Ile Arg Ala 
1               5           


<210>  162
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR2 (6) (DNA)

<400>  162
tatggtgcct ccattagggc c                                                 21


<210>  163
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 (1)

<400>  163

Cys Gln Gln Gly Ile Met Leu Pro Pro 
1               5                   


<210>  164
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 (1) (DNA)

<400>  164
tgtcagcagg gtattatgct tcccccg                                           27


<210>  165
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 (2)

<400>  165

Cys Gln Gln Gly Gln Leu Ile Pro Pro 
1               5                   


<210>  166
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 (2) (DNA)

<400>  166
tgtcagcagg gtcagcttat tccccct                                           27


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 (3)

<400>  167

Cys Gln Gln Gly Gln Val Ile Pro Pro 
1               5                   


<210>  168
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 (3) (DNA)

<400>  168
tgtcagcagg gtcaggttat tccccct                                           27


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 (4)

<400>  169

Cys Gln Gln Gly Gln Gln Ile Pro Pro 
1               5                   


<210>  170
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 (4) (DNA)

<400>  170
tgtcagcagg gtcagcagat tccccct                                           27


<210>  171
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 (5)

<400>  171

Cys Gln Gln Gly Asn Gln Ile Pro Pro 
1               5                   


<210>  172
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 (5) (DNA)

<400>  172
tgtcagcagg gtaatcagat tccccct                                           27


<210>  173
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 (6)

<400>  173

Cys Gln Gln Gly Leu Asn Ile Pro Ser 
1               5                   


<210>  174
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 (6) (DNA)

<400>  174
tgtcagcagg gtctgaatat tccctcg                                           27


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 (7)

<400>  175

Cys Gln Gln Gly His Ile Ile Pro Pro 
1               5                   


<210>  176
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 (7) (DNA)

<400>  176
tgtcagcagg gtcatattat tcccccg                                           27


<210>  177
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 (8)

<400>  177

Cys Gln Gln Ala Ile Met Leu Pro Pro 
1               5                   


<210>  178
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR3 (8) (DNA)

<400>  178
tgtcagcagg ctattatgct tcctccg                                           27


<210>  179
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (1) (DNA 2)

<400>  179
agttatgcta tgagc                                                        15


<210>  180
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (1) (DNA 3)

<400>  180
agttatgcga tgagc                                                        15


<210>  181
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 Kabat (1) (DNA 4)

<400>  181
agttatgcaa tgagc                                                        15


<210>  182
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (1) (DNA 2)

<400>  182
ggattcacct ttagcagtta tgctatgagc                                        30


<210>  183
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (1) (DNA 3)

<400>  183
ggattcacct ttagcagtta tgcgatgagc                                        30


<210>  184
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR1 AbM (1) (DNA 4)

<400>  184
ggattcacct ttagcagtta tgcaatgagc                                        30


<210>  185
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat (1) (DNA 2)

<400>  185
gctattagcg gtagtggtgg tagcacatac tacgcagact ccgtgaag                    48


<210>  186
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia (1) (DNA 2)

<400>  186
agcggtagtg gtggtagcac a                                                 21


<210>  187
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR2 AbM (1) (DNA 2)

<400>  187
gctattagcg gtagtggtgg tagcaca                                           27


<210>  188
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR3 (1) (DNA 2)

<400>  188
tactgtgcga aaggttggtt tggg                                              24


<210>  189
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR3 (2) (DNA 2)

<400>  189
tactgtgcga aagggtggct gggt                                              24


<210>  190
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCDR3 (2) (DNA 3)

<400>  190
tactgtgcga aaggttggtt gggt                                              24


<210>  191
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 (4) (DNA 2)

<400>  191
agggccagtc agagtgttag cagcaactac tta                                    33


<210>  192
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCDR1 (4) (DNA 3)

<400>  192
agggccagtc agagtgttag cagtaactac tta                                    33


<210>  193
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2; VL

<400>  193

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Tyr Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  194
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2; VL

<400>  194
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt atccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  195
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2(YS); VL

<400>  195

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  196
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2(YS); VL

<400>  196
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  197
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F2; VH

<400>  197

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  198
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3F2; VH

<400>  198
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  199
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D9, VL

<400>  199

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Leu Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  200
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D9, VL

<400>  200
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagc ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  201
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D9, VH

<400>  201

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Val Ser Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  202
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D9, VH

<400>  202
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccagact      120

ccagggaagg ggctggagtg ggtctcagct attggtgtta gtactggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

ctgggtcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  203
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D9(TA); VH

<400>  203

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Val Ser Thr Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  204
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D9(TA); VH

<400>  204
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attggtgtta gtactggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

ctgggtcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  205
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G8; VL

<400>  205

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  206
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G8; VL

<400>  206
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc cgcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcatt ggggcctcca ccagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggacg gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  207
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G8; VH

<400>  207

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  208
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G8; VH

<400>  208
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  209
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3; VL

<400>  209

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Tyr Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  210
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B3; VL

<400>  210
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcaattact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggcgcctaca tcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  211
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B3; VH

<400>  211

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  212
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B3; VH

<400>  212
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  213
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D6; VL

<400>  213

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Gln Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  214
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4D6; VL

<400>  214
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatccag ggcgcctcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  215
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D6; VH

<400>  215

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  216
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4D6; VH

<400>  216
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  217
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C6; VL

<400>  217

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Gln Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  218
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C6; VL

<400>  218
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag caggctggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagc agattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  219
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C6; VH

<400>  219

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Ala Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  220
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C6; VH

<400>  220
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatc cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggga gtgctggtta tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

tttgggaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  221
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5H5; VL

<400>  221

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Gln Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  222
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5H5; VL

<400>  222
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtaatc agattccccc tacgttcggt      300

caggggacca aagtggaaat caaa                                             324


<210>  223
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5H5; VH

<400>  223

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Arg Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Phe Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  224
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5H5; VH

<400>  224
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatacca tgagctgggt ccgccggtct      120

ccagggaagg ggctggagtg ggtctcagct attagtggtg gtggtaggac atactacgca      180

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa aggttggttt      300

acgccttttg actactgggg ccaaggaacc ctggtcaccg tctcgagt                   348


<210>  225
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C4; VL

<400>  225

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Gln Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  226
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C4; VL

<400>  226
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agtaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcctcca ttagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtaatc agattccccc tacgttcggt      300

caggggacca aagtggaaat caaa                                             324


<210>  227
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C4; VH

<400>  227

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  228
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2C4; VH

<400>  228
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

tttacgcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  229
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D9; VL

<400>  229

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Gln Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  230
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2D9; VL

<400>  230
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtaatc agattccccc tacgttcggt      300

caggggacca aagtggaaat caaa                                             324


<210>  231
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D9; VH

<400>  231

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  232
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2D9; VH

<400>  232
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

tttacgcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  233
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B8; VL

<400>  233

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  234
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B8; VL

<400>  234
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  235
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B8; VH

<400>  235

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  236
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B8; VH

<400>  236
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  237
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7A1; VL

<400>  237

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Gln Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  238
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7A1; VL

<400>  238
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagc agattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  239
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7A1; VH

<400>  239

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  240
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7A1; VH

<400>  240
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

tttgggaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  241
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13C2; VL

<400>  241

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Leu Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  242
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13C2; VL

<400>  242
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagc ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  243
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13C2; VH

<400>  243

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  244
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13C2; VH

<400>  244
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

ctgggtcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  245
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E8; VL

<400>  245

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Leu Asn Ile Pro 
                85                  90                  95      


Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  246
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13E8; VL

<400>  246
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtctga atattccctc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  247
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E8; VH

<400>  247

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  248
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13E8; VH

<400>  248
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

ttgggtccgt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  249
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14C10; VL

<400>  249

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly His Ile Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  250
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14C10; VL

<400>  250
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcata ttattccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  251
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14C10; VH

<400>  251

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Trp Met Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  252
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14C10; VH

<400>  252
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagcttgg      300

atggggcctt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  253
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17A11; VL

<400>  253

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Leu Asn Ile Pro 
                85                  90                  95      


Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  254
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17A11; VL

<400>  254
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtctga atattccctc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  255
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17A11; VH

<400>  255

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  256
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17A11; VH

<400>  256
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttgg      300

ttgggtccgt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  257
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19G1; VL

<400>  257

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  258
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  19G1; VL

<400>  258
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  259
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19G1; VH

<400>  259

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Ser Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  260
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  19G1; VH

<400>  260
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagcg attattagta gtggtggtct cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  261
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20G8; VL

<400>  261

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  262
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  20G8; VL

<400>  262
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  263
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20G8; VH

<400>  263

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  264
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  20G8; VH

<400>  264
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcaa tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attattggga gtggtagtcg tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  265
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B9; VL

<400>  265

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  266
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B9; VL

<400>  266
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  267
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B9; VH

<400>  267

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  268
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B9; VH

<400>  268
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attattggta gtggtgctag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  269
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5B8; VL

<400>  269

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  270
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5B8; VL

<400>  270
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  271
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5B8; VH

<400>  271

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Gly Gly Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  272
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5B8; VH

<400>  272
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct atttggggtg gtggtcgtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  273
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F1; VL

<400>  273

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  274
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5F1; VL

<400>  274
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  275
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F1; VH

<400>  275

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Ser Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  276
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5F1; VH

<400>  276
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attattagta gtggggctag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  277
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14B3; VL

<400>  277

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  278
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14B3; VL

<400>  278
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  279
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14B3; VH

<400>  279

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Ala Ser Gly Ala Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  280
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14B3; VH

<400>  280
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attttggcta gtggtgcgat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  281
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16F1; VL

<400>  281

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  282
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16F1; VL

<400>  282
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  283
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16F1; VH

<400>  283

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  284
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16F1; VH

<400>  284
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attattggta gtggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  285
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16F8; VL

<400>  285

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  286
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16F8; VL

<400>  286
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  287
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16F8; VH

<400>  287

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  288
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16F8; VH

<400>  288
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attcttggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  289
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O3C9; VL

<400>  289

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  290
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  O3C9; VL

<400>  290
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  291
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O3C9; VH

<400>  291

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  292
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  O3C9; VH

<400>  292
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttttgcca tgagctgggt ccgtcagtct      120

ccagggaagg ggctggagtg ggtctcagct attattggta gtggtagtaa cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  293
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O2D7; VL

<400>  293

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  294
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  O2D7; VL

<400>  294
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcacccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag caggctatta tgcttcctcc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  295
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  O2D7; VH

<400>  295

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  296
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  O2D7; VH

<400>  296
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgtc c               351


<210>  297
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1; VL

<400>  297

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  298
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28H1; VL

<400>  298
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc cgcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcatt ggggcctcca ccagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  299
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28H1; VH

<400>  299

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  300
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28H1; VH

<400>  300
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agtcatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct atttgggcta gtggggagca atactacgca      180

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa agggtggctg      300

ggtaattttg actactgggg ccaaggaacc ctggtcaccg tctcgagt                   348


<210>  301
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  22A3; VL

<400>  301

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  302
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  22A3; VL

<400>  302
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  303
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  22A3; VH

<400>  303

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  304
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  22A3; VH

<400>  304
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attattggta gtggtagtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  305
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29B11; VL

<400>  305

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  306
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29B11; VL

<400>  306
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttacc agtagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcaat gtgggctccc gtagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtatta tgcttccccc gacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  307
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29B11; VH

<400>  307

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  308
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29B11; VH

<400>  308
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attattggta gtggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

tttggtggtt ttaactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  309
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23C10; VL

<400>  309

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  310
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  23C10; VL

<400>  310
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc cgcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatcatt ggggcctcca ccagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagggtcagg ttattccccc tacgttcggc      300

caggggacca aagtggaaat caaa                                             324


<210>  311
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23C10; VH

<400>  311

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Thr Asn Gly Asn Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  312
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  23C10; VH

<400>  312
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttctgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtacta atggtaatta tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagggtgg      300

ctgggtaatt ttgactactg gggccaagga accctggtca ccgtctcgag t               351


<210>  313
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  313

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  314
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  314
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  315
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  315

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  316
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  316
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  317
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human FAP ectodomain+poly-lys-tag+his6-tag

<400>  317

Arg Pro Ser Arg Val His Asn Ser Glu Glu Asn Thr Met Arg Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe 
            20                  25                  30          


Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp Asn 
        35                  40                  45              


Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu 
    50                  55                  60                  


Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser 
65                  70                  75                  80  


Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 
                85                  90                  95      


Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly 
            100                 105                 110         


Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 
        115                 120                 125             


Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn 
145                 150                 155                 160 


Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 
                165                 170                 175     


Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly 
            180                 185                 190         


Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile 
        195                 200                 205             


Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile 
    210                 215                 220                 


Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe Ile 
225                 230                 235                 240 


Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro Val 
                245                 250                 255     


Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 
            260                 265                 270         


Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 
        275                 280                 285             


Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp 
    290                 295                 300                 


Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp 
305                 310                 315                 320 


Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile 
                325                 330                 335     


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
            340                 345                 350         


Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 
        355                 360                 365             


Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 
    370                 375                 380                 


Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
385                 390                 395                 400 


Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys His 
                405                 410                 415     


Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr 
            420                 425                 430         


Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser 
        435                 440                 445             


Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu 
    450                 455                 460                 


Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu 
465                 470                 475                 480 


Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys Met 
                485                 490                 495     


Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
            500                 505                 510         


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala 
        515                 520                 525             


Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala 
    530                 535                 540                 


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr 
545                 550                 555                 560 


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr 
                565                 570                 575     


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile 
            580                 585                 590         


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
        595                 600                 605             


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
    610                 615                 620                 


Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met Gly 
625                 630                 635                 640 


Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
                645                 650                 655     


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
            660                 665                 670         


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
        675                 680                 685             


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
    690                 695                 700                 


Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr Thr 
705                 710                 715                 720 


His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly Lys 
                725                 730                 735     


Lys Lys Lys Lys Lys Gly His His His His His His 
            740                 745             


<210>  318
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human FAP ectodomain+poly-lys-tag+his6-tag

<400>  318
cgcccttcaa gagttcataa ctctgaagaa aatacaatga gagcactcac actgaaggat       60

attttaaatg gaacattttc ttataaaaca ttttttccaa actggatttc aggacaagaa      120

tatcttcatc aatctgcaga taacaatata gtactttata atattgaaac aggacaatca      180

tataccattt tgagtaatag aaccatgaaa agtgtgaatg cttcaaatta cggcttatca      240

cctgatcggc aatttgtata tctagaaagt gattattcaa agctttggag atactcttac      300

acagcaacat attacatcta tgaccttagc aatggagaat ttgtaagagg aaatgagctt      360

cctcgtccaa ttcagtattt atgctggtcg cctgttggga gtaaattagc atatgtctat      420

caaaacaata tctatttgaa acaaagacca ggagatccac cttttcaaat aacatttaat      480

ggaagagaaa ataaaatatt taatggaatc ccagactggg tttatgaaga ggaaatgctt      540

gctacaaaat atgctctctg gtggtctcct aatggaaaat ttttggcata tgcggaattt      600

aatgatacgg atataccagt tattgcctat tcctattatg gcgatgaaca atatcctaga      660

acaataaata ttccataccc aaaggctgga gctaagaatc ccgttgttcg gatatttatt      720

atcgatacca cttaccctgc gtatgtaggt ccccaggaag tgcctgttcc agcaatgata      780

gcctcaagtg attattattt cagttggctc acgtgggtta ctgatgaacg agtatgtttg      840

cagtggctaa aaagagtcca gaatgtttcg gtcctgtcta tatgtgactt cagggaagac      900

tggcagacat gggattgtcc aaagacccag gagcatatag aagaaagcag aactggatgg      960

gctggtggat tctttgtttc aacaccagtt ttcagctatg atgccatttc gtactacaaa     1020

atatttagtg acaaggatgg ctacaaacat attcactata tcaaagacac tgtggaaaat     1080

gctattcaaa ttacaagtgg caagtgggag gccataaata tattcagagt aacacaggat     1140

tcactgtttt attctagcaa tgaatttgaa gaataccctg gaagaagaaa catctacaga     1200

attagcattg gaagctatcc tccaagcaag aagtgtgtta cttgccatct aaggaaagaa     1260

aggtgccaat attacacagc aagtttcagc gactacgcca agtactatgc acttgtctgc     1320

tacggcccag gcatccccat ttccaccctt catgatggac gcactgatca agaaattaaa     1380

atcctggaag aaaacaagga attggaaaat gctttgaaaa atatccagct gcctaaagag     1440

gaaattaaga aacttgaagt agatgaaatt actttatggt acaagatgat tcttcctcct     1500

caatttgaca gatcaaagaa gtatcccttg ctaattcaag tgtatggtgg tccctgcagt     1560

cagagtgtaa ggtctgtatt tgctgttaat tggatatctt atcttgcaag taaggaaggg     1620

atggtcattg ccttggtgga tggtcgagga acagctttcc aaggtgacaa actcctctat     1680

gcagtgtatc gaaagctggg tgtttatgaa gttgaagacc agattacagc tgtcagaaaa     1740

ttcatagaaa tgggtttcat tgatgaaaaa agaatagcca tatggggctg gtcctatgga     1800

ggatacgttt catcactggc ccttgcatct ggaactggtc ttttcaaatg tggtatagca     1860

gtggctccag tctccagctg ggaatattac gcgtctgtct acacagagag attcatgggt     1920

ctcccaacaa aggatgataa tcttgagcac tataagaatt caactgtgat ggcaagagca     1980

gaatatttca gaaatgtaga ctatcttctc atccacggaa cagcagatga taatgtgcac     2040

tttcaaaact cagcacagat tgctaaagct ctggttaatg cacaagtgga tttccaggca     2100

atgtggtact ctgaccagaa ccacggctta tccggcctgt ccacgaacca cttatacacc     2160

cacatgaccc acttcctaaa gcagtgtttc tctttgtcag acggcaaaaa gaaaaagaaa     2220

aagggccacc accatcacca tcac                                            2244


<210>  319
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine FAP ectodomain+poly-lys-tag+his6-tag

<400>  319

Arg Pro Ser Arg Val Tyr Lys Pro Glu Gly Asn Thr Lys Arg Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Tyr Phe 
            20                  25                  30          


Pro Asn Trp Ile Ser Glu Gln Glu Tyr Leu His Gln Ser Glu Asp Asp 
        35                  40                  45              


Asn Ile Val Phe Tyr Asn Ile Glu Thr Arg Glu Ser Tyr Ile Ile Leu 
    50                  55                  60                  


Ser Asn Ser Thr Met Lys Ser Val Asn Ala Thr Asp Tyr Gly Leu Ser 
65                  70                  75                  80  


Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 
                85                  90                  95      


Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Gln Asn Gly 
            100                 105                 110         


Glu Phe Val Arg Gly Tyr Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 
        115                 120                 125             


Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Tyr Thr 
145                 150                 155                 160 


Gly Arg Glu Asn Arg Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 
                165                 170                 175     


Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asp Gly 
            180                 185                 190         


Lys Phe Leu Ala Tyr Val Glu Phe Asn Asp Ser Asp Ile Pro Ile Ile 
        195                 200                 205             


Ala Tyr Ser Tyr Tyr Gly Asp Gly Gln Tyr Pro Arg Thr Ile Asn Ile 
    210                 215                 220                 


Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Val Phe Ile 
225                 230                 235                 240 


Val Asp Thr Thr Tyr Pro His His Val Gly Pro Met Glu Val Pro Val 
                245                 250                 255     


Pro Glu Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 
            260                 265                 270         


Val Ser Ser Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 
        275                 280                 285             


Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp His Ala Trp 
    290                 295                 300                 


Glu Cys Pro Lys Asn Gln Glu His Val Glu Glu Ser Arg Thr Gly Trp 
305                 310                 315                 320 


Ala Gly Gly Phe Phe Val Ser Thr Pro Ala Phe Ser Gln Asp Ala Thr 
                325                 330                 335     


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
            340                 345                 350         


Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 
        355                 360                 365             


Trp Glu Ala Ile Tyr Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 
    370                 375                 380                 


Ser Ser Asn Glu Phe Glu Gly Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
385                 390                 395                 400 


Ile Ser Ile Gly Asn Ser Pro Pro Ser Lys Lys Cys Val Thr Cys His 
                405                 410                 415     


Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Tyr Lys 
            420                 425                 430         


Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Leu Pro Ile Ser 
        435                 440                 445             


Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Gln Val Leu Glu Glu 
    450                 455                 460                 


Asn Lys Glu Leu Glu Asn Ser Leu Arg Asn Ile Gln Leu Pro Lys Val 
465                 470                 475                 480 


Glu Ile Lys Lys Leu Lys Asp Gly Gly Leu Thr Phe Trp Tyr Lys Met 
                485                 490                 495     


Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
            500                 505                 510         


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Lys Ser Val Phe Ala 
        515                 520                 525             


Val Asn Trp Ile Thr Tyr Leu Ala Ser Lys Glu Gly Ile Val Ile Ala 
    530                 535                 540                 


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Phe Leu His 
545                 550                 555                 560 


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Leu Thr 
                565                 570                 575     


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Glu Arg Ile 
            580                 585                 590         


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
        595                 600                 605             


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
    610                 615                 620                 


Ser Ser Trp Glu Tyr Tyr Ala Ser Ile Tyr Ser Glu Arg Phe Met Gly 
625                 630                 635                 640 


Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
                645                 650                 655     


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
            660                 665                 670         


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
        675                 680                 685             


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
    690                 695                 700                 


Asp Gln Asn His Gly Ile Leu Ser Gly Arg Ser Gln Asn His Leu Tyr 
705                 710                 715                 720 


Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly 
                725                 730                 735     


Lys Lys Lys Lys Lys Lys Gly His His His His His His 
            740                 745                 


<210>  320
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine FAP ectodomain+poly-lys-tag+his6-tag

<400>  320
cgtccctcaa gagtttacaa acctgaagga aacacaaaga gagctcttac cttgaaggat       60

attttaaatg gaacattctc atataaaaca tattttccca actggatttc agaacaagaa      120

tatcttcatc aatctgagga tgataacata gtattttata atattgaaac aagagaatca      180

tatatcattt tgagtaatag caccatgaaa agtgtgaatg ctacagatta tggtttgtca      240

cctgatcggc aatttgtgta tctagaaagt gattattcaa agctctggcg atattcatac      300

acagcgacat actacatcta cgaccttcag aatggggaat ttgtaagagg atacgagctc      360

cctcgtccaa ttcagtatct atgctggtcg cctgttggga gtaaattagc atatgtatat      420

caaaacaata tttatttgaa acaaagacca ggagatccac cttttcaaat aacttatact      480

ggaagagaaa atagaatatt taatggaata ccagactggg tttatgaaga ggaaatgctt      540

gccacaaaat atgctctttg gtggtctcca gatggaaaat ttttggcata tgtagaattt      600

aatgattcag atataccaat tattgcctat tcttattatg gtgatggaca gtatcctaga      660

actataaata ttccatatcc aaaggctggg gctaagaatc cggttgttcg tgtttttatt      720

gttgacacca cctaccctca ccacgtgggc ccaatggaag tgccagttcc agaaatgata      780

gcctcaagtg actattattt cagctggctc acatgggtgt ccagtgaacg agtatgcttg      840

cagtggctaa aaagagtgca gaatgtctca gtcctgtcta tatgtgattt cagggaagac      900

tggcatgcat gggaatgtcc aaagaaccag gagcatgtag aagaaagcag aacaggatgg      960

gctggtggat tctttgtttc gacaccagct tttagccagg atgccacttc ttactacaaa     1020

atatttagcg acaaggatgg ttacaaacat attcactaca tcaaagacac tgtggaaaat     1080

gctattcaaa ttacaagtgg caagtgggag gccatatata tattccgcgt aacacaggat     1140

tcactgtttt attctagcaa tgaatttgaa ggttaccctg gaagaagaaa catctacaga     1200

attagcattg gaaactctcc tccgagcaag aagtgtgtta cttgccatct aaggaaagaa     1260

aggtgccaat attacacagc aagtttcagc tacaaagcca agtactatgc actcgtctgc     1320

tatggccctg gcctccccat ttccaccctc catgatggcc gcacagacca agaaatacaa     1380

gtattagaag aaaacaaaga actggaaaat tctctgagaa atatccagct gcctaaagtg     1440

gagattaaga agctcaaaga cgggggactg actttctggt acaagatgat tctgcctcct     1500

cagtttgaca gatcaaagaa gtaccctttg ctaattcaag tgtatggtgg tccttgtagc     1560

cagagtgtta agtctgtgtt tgctgttaat tggataactt atctcgcaag taaggagggg     1620

atagtcattg ccctggtaga tggtcggggc actgctttcc aaggtgacaa attcctgcat     1680

gccgtgtatc gaaaactggg tgtatatgaa gttgaggacc agctcacagc tgtcagaaaa     1740

ttcatagaaa tgggtttcat tgatgaagaa agaatagcca tatggggctg gtcctacgga     1800

ggttatgttt catccctggc ccttgcatct ggaactggtc ttttcaaatg tggcatagca     1860

gtggctccag tctccagctg ggaatattac gcatctatct actcagagag attcatgggc     1920

ctcccaacaa aggacgacaa tctcgaacac tataaaaatt caactgtgat ggcaagagca     1980

gaatatttca gaaatgtaga ctatcttctc atccacggaa cagcagatga taatgtgcac     2040

tttcagaact cagcacagat tgctaaagct ttggttaatg cacaagtgga tttccaggcg     2100

atgtggtact ctgaccagaa ccatggtata ttatctgggc gctcccagaa tcatttatat     2160

acccacatga cgcacttcct caagcaatgc ttttctttat cagacggcaa aaagaaaaag     2220

aaaaagggcc accaccatca ccatcac                                         2247


<210>  321
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cynomolgus FAP ectodomain+poly-lys-tag+his6-tag

<400>  321

Arg Pro Pro Arg Val His Asn Ser Glu Glu Asn Thr Met Arg Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe 
            20                  25                  30          


Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp Asn 
        35                  40                  45              


Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu 
    50                  55                  60                  


Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser 
65                  70                  75                  80  


Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 
                85                  90                  95      


Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly 
            100                 105                 110         


Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 
        115                 120                 125             


Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn 
145                 150                 155                 160 


Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 
                165                 170                 175     


Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly 
            180                 185                 190         


Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile 
        195                 200                 205             


Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile 
    210                 215                 220                 


Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Phe Val Arg Ile Phe Ile 
225                 230                 235                 240 


Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro Val 
                245                 250                 255     


Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 
            260                 265                 270         


Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 
        275                 280                 285             


Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp 
    290                 295                 300                 


Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp 
305                 310                 315                 320 


Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile 
                325                 330                 335     


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
            340                 345                 350         


Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 
        355                 360                 365             


Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 
    370                 375                 380                 


Ser Ser Asn Glu Phe Glu Asp Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
385                 390                 395                 400 


Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys His 
                405                 410                 415     


Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr 
            420                 425                 430         


Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser 
        435                 440                 445             


Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu 
    450                 455                 460                 


Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu 
465                 470                 475                 480 


Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys Met 
                485                 490                 495     


Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
            500                 505                 510         


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala 
        515                 520                 525             


Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala 
    530                 535                 540                 


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr 
545                 550                 555                 560 


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr 
                565                 570                 575     


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile 
            580                 585                 590         


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
        595                 600                 605             


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
    610                 615                 620                 


Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met Gly 
625                 630                 635                 640 


Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
                645                 650                 655     


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
            660                 665                 670         


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
        675                 680                 685             


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
    690                 695                 700                 


Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr Thr 
705                 710                 715                 720 


His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly Lys 
                725                 730                 735     


Lys Lys Lys Lys Lys Gly His His His His His His 
            740                 745             


<210>  322
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cynomolgus FAP ectodomain+poly-lys-tag+his6-tag (DNA)

<400>  322
cgccctccaa gagttcataa ctctgaagaa aatacaatga gagcactcac actgaaggat       60

attttaaatg ggacattttc ttataaaaca ttttttccaa actggatttc aggacaagaa      120

tatcttcatc aatctgcaga taacaatata gtactttata atattgaaac aggacaatca      180

tataccattt tgagtaacag aaccatgaaa agtgtgaatg cttcaaatta tggcttatca      240

cctgatcggc aatttgtata tctagaaagt gattattcaa agctttggag atactcttac      300

acagcaacat attacatcta tgaccttagc aatggagaat ttgtaagagg aaatgagctt      360

cctcgtccaa ttcagtattt atgctggtcg cctgttggga gtaaattagc atatgtctat      420

caaaacaata tctatttgaa acaaagacca ggagatccac cttttcaaat aacatttaat      480

ggaagagaaa ataaaatatt taatggaatc ccagactggg tttatgaaga ggaaatgctt      540

gctacaaaat atgctctctg gtggtctcct aatggaaaat ttttggcata tgcggaattt      600

aatgatacag atataccagt tattgcctat tcctattatg gcgatgaaca atatcccaga      660

acaataaata ttccataccc aaaggccgga gctaagaatc cttttgttcg gatatttatt      720

atcgatacca cttaccctgc gtatgtaggt ccccaggaag tgcctgttcc agcaatgata      780

gcctcaagtg attattattt cagttggctc acgtgggtta ctgatgaacg agtatgtttg      840

cagtggctaa aaagagtcca gaatgtttcg gtcttgtcta tatgtgattt cagggaagac      900

tggcagacat gggattgtcc aaagacccag gagcatatag aagaaagcag aactggatgg      960

gctggtggat tctttgtttc aacaccagtt ttcagctatg atgccatttc atactacaaa     1020

atatttagtg acaaggatgg ctacaaacat attcactata tcaaagacac tgtggaaaat     1080

gctattcaaa ttacaagtgg caagtgggag gccataaata tattcagagt aacacaggat     1140

tcactgtttt attctagcaa tgaatttgaa gattaccctg gaagaagaaa catctacaga     1200

attagcattg gaagctatcc tccaagcaag aagtgtgtta cttgccatct aaggaaagaa     1260

aggtgccaat attacacagc aagtttcagc gactacgcca agtactatgc acttgtctgc     1320

tatggcccag gcatccccat ttccaccctt catgacggac gcactgatca agaaattaaa     1380

atcctggaag aaaacaagga attggaaaat gctttgaaaa atatccagct gcctaaagag     1440

gaaattaaga aacttgaagt agatgaaatt actttatggt acaagatgat tcttcctcct     1500

caatttgaca gatcaaagaa gtatcccttg ctaattcaag tgtatggtgg tccctgcagt     1560

cagagtgtaa ggtctgtatt tgctgttaat tggatatctt atcttgcaag taaggaaggg     1620

atggtcattg ccttggtgga tggtcgggga acagctttcc aaggtgacaa actcctgtat     1680

gcagtgtatc gaaagctggg tgtttatgaa gttgaagacc agattacagc tgtcagaaaa     1740

ttcatagaaa tgggtttcat tgatgaaaaa agaatagcca tatggggctg gtcctatgga     1800

ggatatgttt catcactggc ccttgcatct ggaactggtc ttttcaaatg tgggatagca     1860

gtggctccag tctccagctg ggaatattac gcgtctgtct acacagagag attcatgggt     1920

ctcccaacaa aggatgataa tcttgagcac tataagaatt caactgtgat ggcaagagca     1980

gaatatttca gaaatgtaga ctatcttctc atccacggaa cagcagatga taatgtgcac     2040

tttcaaaact cagcacagat tgctaaagct ctggttaatg cacaagtgga tttccaggca     2100

atgtggtact ctgaccagaa ccacggctta tccggcctgt ccacgaacca cttatacacc     2160

cacatgaccc acttcctaaa gcagtgtttc tctttgtcag acggcaaaaa gaaaaagaaa     2220

aagggccacc accatcacca tcactga                                         2247


<210>  323
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 1

<400>  323

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  324
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 1 (DNA1)

<400>  324
atggactgga cctggagaat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  325
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 1 (DNA 2)

<400>  325
atggactgga cctggaggat cctcttcttg gtggcagcag ccacaggagc ccactcc          57


<210>  326
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 2

<400>  326

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys 
            20          


<210>  327
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 2 (DNA)

<400>  327
atggacatga gggtccccgc tcagctcctg ggcctcctgc tgctctggtt cccaggtgcc       60

aggtgt                                                                  66


<210>  328
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 3

<400>  328

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  329
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 3 (DNA 1)

<400>  329
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattcc          57


<210>  330
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 3 (DNA 1)

<400>  330
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccactggagt gcattcc          57


<210>  331
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader Sequence 3 (DNA 3)

<400>  331
atgggctggt cctgcatcat cctgtttctg gtcgccacag ccaccggcgt gcactct          57


<210>  332
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMB3

<400>  332
caggaaacag ctatgaccat gattac                                            26


<210>  333
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LibL1b_new


<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is a, c, g, or t

<400>  333
cactttggtc ccctggccga acgtmnnggg mnnmnnmnna ccctgctgac agtaatacac       60

tgc                                                                     63


<210>  334
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS63

<400>  334
tttcgcacag taatatacgg ccgtgtcc                                          28


<210>  335
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS64

<400>  335
acgttcggcc aggggaccaa agtgg                                             25


<210>  336
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lib2H


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<400>  336
ggccgtatat tactgtgcga aannknnknn knnknnkttt gactactggg gccaaggaac       60


<210>  337
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fdseqlong

<400>  337
gacgttagta aatgaatttt ctgtatgagg                                        30


<210>  338
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH_LIB3


<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  n is a, c, g, or t

<400>  338
gactttggtg ccctggccaa acgtmnnggg mnnmnnaccm nnctgcaagc agtaataggt       60

ggcaaaatc                                                               69


<210>  339
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH31

<400>  339
acgtttggcc agggcaccaa agtcgag                                           27


<210>  340
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH32

<400>  340
tctcgcacag taatacacgg cggtgtcc                                          28


<210>  341
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIB88_2


<220>
<221>  misc_difference
<222>  (29)..(55)
<223>  (33% GAC Asp; 26% GGT Gly; 10% GAA Glu; 9% CGT Arg; 7% Lys; 6% 
       GTT Val; 5% TCT Ser; 4% CTG Leu)1 - (23% GGT Gly; 17% TAC Tyr; 
       16% TCT Ser; 11% GCT Ala; 9% CGT Arg; 7% AAC Asn; 6% ACT Thr; 6% 
       GTT Val; 5% CCG Pro)8

<220>
<221>  misc_feature
<222>  (30)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (44)..(45)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  n is a, c, g, or t

<400>  341
ggacaccgcc gtgtattact gtgcgagabn nnnbnnbnnb nnbnnbnnbn nbnnbtttga       60

ctactggggc caagggacca ccgtgaccgt ctcc                                   94


<210>  342
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DPK22_CDR1_rand_ba_opt

<400>  342
caggtttctg ctggtaccag gctaagtagc tgctgctaac actctgactg gccctgcaag       60


<210>  343
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DPK22_CDR1_fo

<400>  343
ttagcctggt accagcagaa acctg                                             25


<210>  344
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DPK22_Ck_BsiWI_ba

<400>  344
ggtgcagcca ccgtacgttt gatttcc                                           27


<210>  345
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DPK22_CDR2_rand_ba

<400>  345
ctgtctggga tgccagtggc cctgctggag gcgccataga tgaggagcct gggagcctg        59


<210>  346
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DPK22_CDR2_fo

<400>  346
agggccactg gcatcccaga cag                                               23


<210>  347
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH53

<400>  347
catcagggcc tgagctcgcc cgtcac                                            26


<210>  348
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47_CDR1_rand_ba_opt

<400>  348
gagcctggcg gacccagctc atggcataac tgctaaaggt gaatccggag gc               52


<210>  349
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47_CDR1_fo

<400>  349
atgagctggg tccgccaggc tc                                                22


<210>  350
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS52

<400>  350
gaagaccgat gggcctttgg tgctag                                            26


<210>  351
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47_CDR2_rand_ba

<400>  351
ccttcacgga gtctgcgtag tatgtgctac caccactacc actaatagct gagacccact       60

ccagcccctt ccc                                                          73


<210>  352
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47_CDR2_fo

<400>  352
acatactacg cagactccgt gaagg                                             25


