                         SEQUENCE LISTING

<110>  Vaaje-Kolstad, Gustav
       Westereng, Bjorge
       Eijsink, Vincent G.H.
       Horn, Svein J.
       Sorlie, Morten
       Forsberg, Zarah
 
<120>  METHODS OF DEGRADING OR HYDROLYZING A POLYSACCHARIDE

<130>  12287-WO-PCT

<150>  GB 1013317.1
<151>  2010-08-06

<150>  GB 1016858.1
<151>  2010-10-16

<150>  GB 1105062.2
<151>  2011-03-25

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  452
<212>  PRT
<213>  T. terrestris

<400>  1

Met Leu Ala Asn Gly Ala Ile Val Phe Leu Ala Ala Ala Leu Gly Val 
1               5                   10                  15      


Ser Gly His Tyr Thr Trp Pro Arg Val Asn Asp Gly Ala Asp Trp Gln 
            20                  25                  30          


Gln Val Arg Lys Ala Asp Asn Trp Gln Asp Asn Gly Tyr Val Gly Asp 
        35                  40                  45              


Val Thr Ser Pro Gln Ile Arg Cys Phe Gln Ala Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Val Leu Asn Thr Thr Ala Gly Ser Thr Val Thr Tyr Trp Ala 
65                  70                  75                  80  


Asn Pro Asp Val Tyr His Pro Gly Pro Val Gln Phe Tyr Met Ala Arg 
                85                  90                  95      


Val Pro Asp Gly Glu Asp Ile Asn Ser Trp Asn Gly Asp Gly Ala Val 
            100                 105                 110         


Trp Phe Lys Val Tyr Glu Asp His Pro Thr Phe Gly Ala Gln Leu Thr 
        115                 120                 125             


Trp Pro Ser Thr Gly Lys Ser Ser Phe Ala Val Pro Ile Pro Pro Cys 
    130                 135                 140                 


Ile Lys Ser Gly Tyr Tyr Leu Leu Arg Ala Glu Gln Ile Gly Leu His 
145                 150                 155                 160 


Val Ala Gln Ser Val Gly Gly Ala Gln Phe Tyr Ile Ser Cys Ala Gln 
                165                 170                 175     


Leu Ser Val Thr Gly Gly Gly Ser Thr Glu Pro Pro Asn Lys Val Ala 
            180                 185                 190         


Phe Pro Gly Ala Tyr Ser Ala Thr Asp Pro Gly Ile Leu Ile Asn Ile 
        195                 200                 205             


Tyr Tyr Pro Val Pro Thr Ser Tyr Gln Asn Pro Gly Pro Ala Val Phe 
    210                 215                 220                 


Ser Cys Met Leu Ala Asn Gly Ala Ile Val Phe Leu Ala Ala Ala Leu 
225                 230                 235                 240 


Gly Val Ser Gly His Tyr Thr Trp Pro Arg Val Asn Asp Gly Ala Asp 
                245                 250                 255     


Trp Gln Gln Val Arg Lys Ala Asp Asn Trp Gln Asp Asn Gly Tyr Val 
            260                 265                 270         


Gly Asp Val Thr Ser Pro Gln Ile Arg Cys Phe Gln Ala Thr Pro Ser 
        275                 280                 285             


Pro Ala Pro Ser Val Leu Asn Thr Thr Ala Gly Ser Thr Val Thr Tyr 
    290                 295                 300                 


Trp Ala Asn Pro Asp Val Tyr His Pro Gly Pro Val Gln Phe Tyr Met 
305                 310                 315                 320 


Ala Arg Val Pro Asp Gly Glu Asp Ile Asn Ser Trp Asn Gly Asp Gly 
                325                 330                 335     


Ala Val Trp Phe Lys Val Tyr Glu Asp His Pro Thr Phe Gly Ala Gln 
            340                 345                 350         


Leu Thr Trp Pro Ser Thr Gly Lys Ser Ser Phe Ala Val Pro Ile Pro 
        355                 360                 365             


Pro Cys Ile Lys Ser Gly Tyr Tyr Leu Leu Arg Ala Glu Gln Ile Gly 
    370                 375                 380                 


Leu His Val Ala Gln Ser Val Gly Gly Ala Gln Phe Tyr Ile Ser Cys 
385                 390                 395                 400 


Ala Gln Leu Ser Val Thr Gly Gly Gly Ser Thr Glu Pro Pro Asn Lys 
                405                 410                 415     


Val Ala Phe Pro Gly Ala Tyr Ser Ala Thr Asp Pro Gly Ile Leu Ile 
            420                 425                 430         


Asn Ile Tyr Tyr Pro Val Pro Thr Ser Tyr Gln Asn Pro Gly Pro Ala 
        435                 440                 445             


Val Phe Ser Cys 
    450         


<210>  2
<211>  250
<212>  PRT
<213>  T. aurantiacus

<400>  2

Met Ser Phe Ser Lys Ile Ile Ala Thr Ala Gly Val Leu Ala Ser Ala 
1               5                   10                  15      


Ser Leu Val Ala Gly His Gly Phe Val Gln Asn Ile Val Ile Asp Gly 
            20                  25                  30          


Lys Lys Tyr Tyr Gly Gly Tyr Leu Val Asn Gln Tyr Pro Tyr Met Ser 
        35                  40                  45              


Asn Pro Pro Glu Val Ile Ala Trp Ser Thr Thr Ala Thr Asp Leu Gly 
    50                  55                  60                  


Phe Val Asp Gly Thr Gly Tyr Gln Thr Pro Asp Ile Ile Cys His Arg 
65                  70                  75                  80  


Gly Ala Lys Pro Gly Ala Leu Thr Ala Pro Val Ser Pro Gly Gly Thr 
                85                  90                  95      


Val Glu Leu Gln Trp Thr Pro Trp Pro Asp Ser His His Gly Pro Val 
            100                 105                 110         


Ile Asn Tyr Leu Ala Pro Cys Asn Gly Asp Cys Ser Thr Val Asp Lys 
        115                 120                 125             


Thr Gln Leu Glu Phe Phe Lys Ile Ala Glu Ser Gly Leu Ile Asn Asp 
    130                 135                 140                 


Asp Asn Pro Pro Gly Ile Trp Ala Ser Asp Asn Leu Ile Ala Ala Asn 
145                 150                 155                 160 


Asn Ser Trp Thr Val Thr Ile Pro Thr Thr Ile Ala Pro Gly Asn Tyr 
                165                 170                 175     


Val Leu Arg His Glu Ile Ile Ala Leu His Ser Ala Gln Asn Gln Asp 
            180                 185                 190         


Gly Ala Gln Asn Tyr Pro Gln Cys Ile Asn Leu Gln Val Thr Gly Gly 
        195                 200                 205             


Gly Ser Asp Asn Pro Ala Gly Thr Leu Gly Thr Ala Leu Tyr His Asp 
    210                 215                 220                 


Thr Asp Pro Gly Ile Leu Ile Asn Ile Tyr Gln Lys Leu Ser Ser Tyr 
225                 230                 235                 240 


Ile Ile Pro Gly Pro Pro Leu Tyr Thr Gly 
                245                 250 


<210>  3
<211>  276
<212>  PRT
<213>  T. terrestris

<400>  3

Ala Ser Asp Asp Ile Arg Cys Asn Val Gly Thr Ser Arg Pro Thr Val 
1               5                   10                  15      


Lys Cys Pro Val Lys Ala Gly Ser Thr Val Thr Ile Glu Met His Gln 
            20                  25                  30          


Gln Pro Gly Asp Arg Ser Cys Ala Asn Glu Ala Ile Gly Gly Asp His 
        35                  40                  45              


Tyr Gly Pro Val Met Val Tyr Met Ser Lys Val Asp Asp Ala Val Thr 
    50                  55                  60                  


Ala Asp Gly Ser Ser Gly Trp Phe Lys Val Phe Gln Asp Ser Trp Ala 
65                  70                  75                  80  


Lys Asn Pro Ser Gly Ser Thr Gly Asp Asp Asp Tyr Trp Gly Thr Lys 
                85                  90                  95      


Asp Leu Asn Ser Cys Cys Gly Lys Met Asn Val Lys Ile Pro Glu Asp 
            100                 105                 110         


Ile Glu Pro Gly Asp Tyr Leu Leu Arg Ala Glu Val Ile Ala Leu His 
        115                 120                 125             


Val Ala Ala Ser Ser Gly Gly Ala Gln Phe Tyr Met Ser Cys Tyr Gln 
    130                 135                 140                 


Leu Thr Val Thr Gly Ser Gly Ser Ala Thr Pro Ser Thr Val Asn Phe 
145                 150                 155                 160 


Pro Gly Ala Tyr Ser Ala Ser Asp Pro Gly Ile Leu Ile Asn Ile His 
                165                 170                 175     


Ala Pro Met Ser Thr Tyr Val Val Pro Gly Pro Thr Val Tyr Ala Gly 
            180                 185                 190         


Gly Ser Thr Lys Ser Ala Gly Ser Ser Cys Ser Gly Cys Glu Ala Thr 
        195                 200                 205             


Cys Thr Val Gly Ser Gly Pro Ser Ala Thr Leu Thr Gln Pro Thr Ser 
    210                 215                 220                 


Thr Ala Thr Ala Thr Ser Ala Pro Gly Gly Gly Gly Ser Gly Cys Thr 
225                 230                 235                 240 


Ala Ala Lys Tyr Gln Gln Cys Gly Gly Thr Gly Tyr Thr Gly Cys Thr 
                245                 250                 255     


Thr Cys Ala Ser Gly Ser Thr Cys Ser Ala Val Ser Pro Pro Tyr Tyr 
            260                 265                 270         


Ser Gln Cys Leu 
        275     


<210>  4
<211>  197
<212>  PRT
<213>  Serratia marescens

<400>  4

Met Asn Lys Thr Ser Arg Thr Leu Leu Ser Leu Gly Leu Leu Ser Ala 
1               5                   10                  15      


Ala Met Phe Gly Val Ser Gln Gln Ala Asn Ala His Gly Tyr Val Glu 
            20                  25                  30          


Ser Pro Ala Ser Arg Ala Tyr Gln Cys Lys Leu Gln Leu Asn Thr Gln 
        35                  40                  45              


Cys Gly Ser Val Gln Tyr Glu Pro Gln Ser Val Glu Gly Leu Lys Gly 
    50                  55                  60                  


Phe Pro Gln Ala Gly Pro Ala Asp Gly His Ile Ala Ser Ala Asp Lys 
65                  70                  75                  80  


Ser Thr Phe Phe Glu Leu Asp Gln Gln Thr Pro Thr Arg Trp Asn Lys 
                85                  90                  95      


Leu Asn Leu Lys Thr Gly Pro Asn Ser Phe Thr Trp Lys Leu Thr Ala 
            100                 105                 110         


Arg His Ser Thr Thr Ser Trp Arg Tyr Phe Ile Thr Lys Pro Asn Trp 
        115                 120                 125             


Asp Ala Ser Gln Pro Leu Thr Arg Ala Ser Phe Asp Leu Thr Pro Phe 
    130                 135                 140                 


Cys Gln Phe Asn Asp Gly Gly Ala Ile Pro Ala Ala Gln Val Thr His 
145                 150                 155                 160 


Gln Cys Asn Ile Pro Ala Asp Arg Ser Gly Ser His Val Ile Leu Ala 
                165                 170                 175     


Val Trp Asp Ile Ala Asp Thr Ala Asn Ala Phe Tyr Gln Ala Ile Asp 
            180                 185                 190         


Val Asn Leu Ser Lys 
        195         


<210>  5
<211>  194
<212>  PRT
<213>  Enterococcus faecalis

<400>  5

Met Lys Lys Ser Leu Leu Thr Ile Val Leu Ala Phe Ser Phe Val Leu 
1               5                   10                  15      


Gly Gly Ala Ala Leu Ala Pro Thr Val Ser Glu Ala His Gly Tyr Val 
            20                  25                  30          


Ala Ser Pro Gly Ser Arg Ala Phe Phe Gly Ser Ser Ala Gly Gly Asn 
        35                  40                  45              


Leu Asn Thr Asn Val Gly Arg Ala Gln Trp Glu Pro Gln Ser Ile Glu 
    50                  55                  60                  


Ala Pro Lys Asn Thr Phe Ile Thr Gly Lys Leu Ala Ser Ala Gly Val 
65                  70                  75                  80  


Ser Gly Phe Glu Pro Leu Asp Glu Gln Thr Ala Thr Arg Trp His Lys 
                85                  90                  95      


Thr Asn Ile Thr Thr Gly Pro Leu Asp Ile Thr Trp Asn Leu Thr Ala 
            100                 105                 110         


Gln His Arg Thr Ala Ser Trp Asp Tyr Tyr Ile Thr Lys Asn Gly Trp 
        115                 120                 125             


Asn Pro Asn Gln Pro Leu Asp Ile Lys Asn Phe Asp Lys Ile Ala Ser 
    130                 135                 140                 


Ile Asp Gly Lys Gln Glu Val Pro Asn Lys Val Val Lys Gln Thr Ile 
145                 150                 155                 160 


Asn Ile Pro Thr Asp Arg Lys Gly Tyr His Val Ile Tyr Ala Val Trp 
                165                 170                 175     


Gly Ile Gly Asp Thr Val Asn Ala Phe Tyr Gln Ala Ile Asp Val Asn 
            180                 185                 190         


Ile Gln 
        


<210>  6
<211>  222
<212>  PRT
<213>  Thermobifida fusca

<400>  6

Met His Arg Tyr Ser Arg Thr Gly Lys His Arg Trp Thr Val Arg Ala 
1               5                   10                  15      


Leu Ala Val Leu Phe Thr Ala Leu Leu Gly Leu Thr Gln Trp Thr Ala 
            20                  25                  30          


Pro Ala Ser Ala His Gly Ser Val Ile Asn Pro Ala Thr Arg Asn Tyr 
        35                  40                  45              


Gly Cys Trp Leu Arg Trp Gly His Asp His Leu Asn Pro Asn Met Gln 
    50                  55                  60                  


Tyr Glu Asp Pro Met Cys Trp Gln Ala Trp Gln Asp Asn Pro Asn Ala 
65                  70                  75                  80  


Met Trp Asn Trp Asn Gly Leu Tyr Arg Asp Trp Val Gly Gly Asn His 
                85                  90                  95      


Arg Ala Ala Leu Pro Asp Gly Gln Leu Cys Ser Gly Gly Leu Thr Glu 
            100                 105                 110         


Gly Gly Arg Tyr Arg Ser Met Asp Ala Val Gly Pro Trp Lys Thr Thr 
        115                 120                 125             


Asp Val Asn Asn Thr Phe Thr Ile His Leu Tyr Asp Gln Ala Ser His 
    130                 135                 140                 


Gly Ala Asp Tyr Phe Leu Val Tyr Val Thr Lys Gln Gly Phe Asp Pro 
145                 150                 155                 160 


Thr Thr Gln Pro Leu Thr Trp Asp Ser Leu Glu Leu Val His Gln Thr 
                165                 170                 175     


Gly Ser Tyr Pro Pro Ala Gln Asn Ile Gln Phe Thr Val His Ala Pro 
            180                 185                 190         


Asn Arg Ser Gly Arg His Val Val Phe Thr Ile Trp Lys Ala Ser His 
        195                 200                 205             


Met Asp Gln Thr Tyr Tyr Leu Cys Ser Asp Val Asn Phe Val 
    210                 215                 220         


<210>  7
<211>  364
<212>  PRT
<213>  Streptomyces coelicolor

<400>  7

Met Val Arg Arg Thr Arg Leu Leu Thr Leu Ala Ala Val Leu Ala Thr 
1               5                   10                  15      


Leu Leu Gly Ser Leu Gly Val Thr Leu Leu Leu Gly Gln Gly Arg Ala 
            20                  25                  30          


Glu Ala His Gly Val Ala Met Met Pro Gly Ser Arg Thr Tyr Leu Cys 
        35                  40                  45              


Gln Leu Asp Ala Lys Thr Gly Thr Gly Ala Leu Asp Pro Thr Asn Pro 
    50                  55                  60                  


Ala Cys Gln Ala Ala Leu Asp Gln Ser Gly Ala Thr Ala Leu Tyr Asn 
65                  70                  75                  80  


Trp Phe Ala Val Leu Asp Ser Asn Ala Gly Gly Arg Gly Ala Gly Tyr 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Cys Ser Ala Gly Asp Arg Ser Pro Tyr Asp 
            100                 105                 110         


Phe Ser Ala Tyr Asn Ala Ala Arg Ser Asp Trp Pro Arg Thr His Leu 
        115                 120                 125             


Thr Ser Gly Ala Thr Ile Pro Val Glu Tyr Ser Asn Trp Ala Ala His 
    130                 135                 140                 


Pro Gly Asp Phe Arg Val Tyr Leu Thr Lys Pro Gly Trp Ser Pro Thr 
145                 150                 155                 160 


Ser Glu Leu Gly Trp Asp Asp Leu Glu Leu Ile Gln Thr Val Thr Asn 
                165                 170                 175     


Pro Pro Gln Gln Gly Ser Pro Gly Thr Asp Gly Gly His Tyr Tyr Trp 
            180                 185                 190         


Asp Leu Ala Leu Pro Ser Gly Arg Ser Gly Asp Ala Leu Ile Phe Met 
        195                 200                 205             


Gln Trp Val Arg Ser Asp Ser Gln Glu Asn Phe Phe Ser Cys Ser Asp 
    210                 215                 220                 


Val Val Phe Asp Gly Gly Asn Gly Glu Val Thr Gly Ile Arg Gly Ser 
225                 230                 235                 240 


Gly Ser Thr Pro Asp Pro Asp Pro Thr Pro Thr Pro Thr Asp Pro Thr 
                245                 250                 255     


Thr Pro Pro Thr His Thr Gly Ser Cys Met Ala Val Tyr Ser Val Glu 
            260                 265                 270         


Asn Ser Trp Ser Gly Gly Phe Gln Gly Ser Val Glu Val Met Asn His 
        275                 280                 285             


Gly Thr Glu Pro Leu Asn Gly Trp Ala Val Gln Trp Gln Pro Gly Gly 
    290                 295                 300                 


Gly Thr Thr Leu Gly Gly Val Trp Asn Gly Ser Leu Thr Ser Gly Ser 
305                 310                 315                 320 


Asp Gly Thr Val Thr Val Arg Asn Val Asp His Asn Arg Val Val Pro 
                325                 330                 335     


Pro Asp Gly Ser Val Thr Phe Gly Phe Thr Ala Thr Ser Thr Gly Asn 
            340                 345                 350         


Asp Phe Pro Val Asp Ser Ile Gly Cys Val Ala Pro 
        355                 360                 


<210>  8
<211>  400
<212>  PRT
<213>  Cellulomonas flavigena DSM 20109

<400>  8

Met Pro Arg His Arg Ser Thr Arg Arg Ala Leu Ala Gly Leu Ala Ala 
1               5                   10                  15      


Thr Ala Val Val Thr Thr Ala Leu Val Thr Val Pro Thr Val Ala Gln 
            20                  25                  30          


Ala His Gly Gly Leu Thr Asn Pro Pro Thr Arg Thr Tyr Ala Cys Tyr 
        35                  40                  45              


Gln Asp Gly Leu Ala Gly Gly Ala Ala Ala Gly Glu Ala Gly Asn Ile 
    50                  55                  60                  


Arg Pro Arg Asn Ala Ala Cys Val Asn Ala Phe Asp Asn Glu Gly Asn 
65                  70                  75                  80  


Tyr Ser Phe Tyr Asn Trp Tyr Gly Asn Leu Leu Gly Thr Ile Ala Gly 
                85                  90                  95      


Arg His Glu Thr Ile Ala Asp Gly Lys Val Cys Gly Pro Asp Ala Arg 
            100                 105                 110         


Phe Ala Ser Tyr Asn Thr Pro Ser Ser Ala Trp Pro Thr Thr Lys Val 
        115                 120                 125             


Thr Pro Gly Gln Thr Met Thr Phe Gln Tyr Ala Ala Val Ala Arg His 
    130                 135                 140                 


Pro Gly Trp Phe Thr Thr Trp Ile Thr Lys Asp Gly Trp Asn Gln Asn 
145                 150                 155                 160 


Glu Pro Ile Gly Trp Asp Asp Leu Glu Pro Ala Pro Phe Asp Arg Val 
                165                 170                 175     


Leu Asp Pro Pro Leu Arg Glu Gly Gly Pro Ala Gly Pro Glu Tyr Trp 
            180                 185                 190         


Trp Asn Val Lys Leu Pro Ser Asn Lys Ser Gly Lys His Val Leu Phe 
        195                 200                 205             


Asn Ile Trp Glu Arg Thr Asp Ser Pro Glu Ser Phe Tyr Asn Cys Val 
    210                 215                 220                 


Asp Val Asp Phe Gly Gly Gly Gly Thr Val Thr Pro Ser Pro Thr Pro 
225                 230                 235                 240 


Ser Val Thr Pro Thr Arg Thr Pro Thr Pro Ser Pro Thr Pro Ser Val 
                245                 250                 255     


Thr Pro Ser Pro Thr Pro Ser Val Thr Pro Thr Pro Thr Pro Thr Pro 
            260                 265                 270         


Thr Pro Thr Pro Ser Pro Thr Pro Thr Leu Thr Val Thr Pro Thr Pro 
        275                 280                 285             


Thr Pro Thr Ser Val Pro Gly Asp Ser Val Cys Glu Leu Glu Val Asp 
    290                 295                 300                 


Thr Ser Ser Ala Trp Pro Gly Gly Phe Gln Gly Thr Val Thr Val Phe 
305                 310                 315                 320 


Asn Ala Thr Met Glu Pro Val Asn Gly Trp Gln Val Ser Trp Lys Phe 
                325                 330                 335     


Thr Asn Gly Glu Thr Ile Ala Gln Ser Trp Ser Gly Val Thr Ser Gln 
            340                 345                 350         


Ser Gly Ser Thr Val Thr Val Lys Asn Ala Asp Trp Asn Ser Thr Ile 
        355                 360                 365             


Ala His His Asn Ala Val Asn Phe Gly Phe Ile Gly Ser Gly Thr Pro 
    370                 375                 380                 


Lys Ala Val Thr Asp Ala Thr Leu Asn Gly Lys Pro Cys Ile Val Arg 
385                 390                 395                 400 


<210>  9
<211>  362
<212>  PRT
<213>  Cellulomonas flavigena

<400>  9

Met Phe Ile Pro Thr Arg Ser Arg Phe Gly Arg Leu Ala Arg Leu Ala 
1               5                   10                  15      


Leu Ala Val Pro Leu Ala Leu Ala Ala Thr Gly Ile Val Ala Thr Ser 
            20                  25                  30          


Ala Ser Ala His Gly Ser Val Thr Asp Pro Pro Ser Arg Asn Tyr Gly 
        35                  40                  45              


Cys Trp Glu Arg Glu Gly Gly Thr His Met Asp Pro Ala Met Ala Gln 
    50                  55                  60                  


Arg Asp Pro Met Cys Trp Gln Ala Phe Gln Ala Asn Pro Asn Thr Met 
65                  70                  75                  80  


Trp Asn Trp Asn Gly Asn Phe Arg Glu Gly Val Gly Gly Arg His Glu 
                85                  90                  95      


Gln Val Ile Pro Asp Asp Gln Leu Cys Ser Ala Gly Lys Thr Gln Asn 
            100                 105                 110         


Gly Leu Tyr Ala Ser Leu Asp Thr Pro Gly Pro Trp Ile Met Lys Thr 
        115                 120                 125             


Val Pro His Asn Phe Thr Leu Thr Leu Thr Asp Gly Ala Met His Gly 
    130                 135                 140                 


Ala Asp Tyr Met Arg Ile Tyr Val Ser Lys Ala Gly Tyr Asp Pro Thr 
145                 150                 155                 160 


Thr Asp Pro Leu Gly Trp Asp Asp Ile Glu Leu Ile Lys Glu Thr Gly 
                165                 170                 175     


Arg Tyr Gly Thr Thr Gly Leu Tyr Gln Ala Asp Val Ser Ile Pro Ser 
            180                 185                 190         


Asn Arg Thr Gly Arg Ala Val Leu Phe Thr Ile Trp Gln Ala Ser His 
        195                 200                 205             


Leu Asp Gln Pro Tyr Tyr Ile Cys Ser Asp Ile Asn Ile Asn Gly Thr 
    210                 215                 220                 


Ala Pro Thr Gln Gln Pro Thr Gln Gln Pro Thr Gln Gln Pro Thr Gln 
225                 230                 235                 240 


Gln Pro Thr Gln Gln Pro Thr Gln Gln Pro Thr Gln Gln Pro Thr Gln 
                245                 250                 255     


Gln Pro Thr Gln Gln Pro Thr Gln Gln Pro Thr Gln Asn Pro Gly Thr 
            260                 265                 270         


Gly Ala Cys Thr Ala Thr Val Lys Ala Ala Ser Thr Trp Gly Asn Gly 
        275                 280                 285             


Trp Gln Gly Glu Val Thr Val Thr Ala Gly Ser Ser Ala Ile Asn Gly 
    290                 295                 300                 


Trp Lys Val Thr Val Gly Gly Ala Ser Ile Thr Gln Ala Trp Ser Gly 
305                 310                 315                 320 


Ser Tyr Ser Gly Gly Thr Phe Ser Asn Ala Glu Trp Asn Gly Lys Leu 
                325                 330                 335     


Ala Ala Gly Ala Ser Thr Thr Ala Gly Phe Ile Ala Ser Gly Thr Pro 
            340                 345                 350         


Gly Thr Leu Thr Ala Thr Cys Thr Ala Ala 
        355                 360         


<210>  10
<211>  368
<212>  PRT
<213>  Cellulomonas flavigena DSM 20109

<400>  10

Met Ser Arg Ile Ser Pro Leu Arg Arg Val Ala Ala Ala Cys Gly Ala 
1               5                   10                  15      


Leu Ala Ile Gly Ala Ala Thr Val Val Gly Ser Ile Ala Leu Ala Ala 
            20                  25                  30          


Pro Ala Ser Ala His Gly Ala Val Ser Asp Pro Pro Ser Arg Ile Tyr 
        35                  40                  45              


Gly Cys Trp Glu Arg Trp Ala Ser Asn Phe Thr Asp Pro Ala Met Ala 
    50                  55                  60                  


Thr Ser Asp Pro Gln Cys Trp Asp Ala Trp Gln Ser Glu Pro Gln Ala 
65                  70                  75                  80  


Met Trp Asn Trp Asn Gly Met Phe Lys Glu Gly Ala Ala Gly Gln His 
                85                  90                  95      


Glu Gln Ser Ile Pro Asp Gly Lys Leu Cys Ser Ala Asp Asn Pro Leu 
            100                 105                 110         


Tyr Ala Ala Ala Asp Asp Pro Gly Pro Trp Arg Thr Thr Pro Val Asp 
        115                 120                 125             


His Asp Phe Arg Leu Thr Leu His Asp Pro Ser Asn His Gly Ala Asp 
    130                 135                 140                 


Tyr Leu Lys Ile Tyr Val Thr Lys Gln Gly Tyr Asp Ala Arg Ser Glu 
145                 150                 155                 160 


Ala Leu Thr Trp Ala Asp Leu Glu Leu Val Lys Thr Thr Gly Arg Tyr 
                165                 170                 175     


Ala Thr Ser Ser Pro Tyr Val Thr Asp Val Ser Val Pro Arg Asp Arg 
            180                 185                 190         


Thr Gly His His Val Val Phe Thr Ile Trp Gln Ala Ser His Leu Asp 
        195                 200                 205             


Gln Pro Tyr Tyr Gln Cys Ser Asp Val Thr Phe Gly Gly Gly Gly Thr 
    210                 215                 220                 


Pro Thr Thr Ser Pro Thr Thr Pro Ala Pro Thr Pro Thr Thr Pro Ala 
225                 230                 235                 240 


Pro Thr Thr Pro Ala Pro Thr Pro Thr Thr Pro Ala Pro Thr Thr Pro 
                245                 250                 255     


Ala Pro Thr Thr Pro Ala Pro Thr Thr Pro Ala Pro Thr Thr Pro Ala 
            260                 265                 270         


Pro Thr Gln Pro Ala Asp Gly Ala Cys Thr Ala Ala Ile Glu Val Val 
        275                 280                 285             


Ser Ala Trp Gln Gly Gly Tyr Gln Ala Thr Val Thr Val Thr Ala Gly 
    290                 295                 300                 


Ser Gly Gly Leu Asp Gly Trp Thr Val Thr Val Pro Gly Ala Thr Ile 
305                 310                 315                 320 


Thr Gln Ala Trp Asn Gly Thr Ala Thr Gly Ser Thr Ile Thr Ala Ala 
                325                 330                 335     


Gly Trp Asn Gly Thr Val Ala Ala Gly Gly Thr Ala Gly Val Gly Phe 
            340                 345                 350         


Leu Gly Ser Gly Ser Pro Asp Gly Leu Thr Ala Thr Cys Ala Ala Ala 
        355                 360                 365             


<210>  11
<211>  313
<212>  PRT
<213>  Cellulomonas flavigena DSM 20109

<400>  11

Met Arg Ser His Ala Leu Pro Arg Ser Ala Arg Pro Thr Pro Gly Arg 
1               5                   10                  15      


Leu Leu Leu Ser Val Leu Ala Val Ile Ala Leu Ala Phe Ala Val Leu 
            20                  25                  30          


Thr Val Ala Pro Ala Pro Ser Ala Gln Ala His Gly Trp Ile Ser Asp 
        35                  40                  45              


Pro Pro Ser Arg Gln Asp Leu Cys Tyr Thr Gly Ala Val Ser Asn Cys 
    50                  55                  60                  


Gly Pro Val Met Tyr Glu Pro Trp Ser Val Glu Ala Lys Lys Gly Ser 
65                  70                  75                  80  


Met Gln Cys Ser Gly Gly Gly Arg Phe Thr Glu Leu Asp Asn Glu Ser 
                85                  90                  95      


Arg Ser Trp Pro Arg Gln Asn Leu Lys Thr Asn Gln Val Phe Thr Trp 
            100                 105                 110         


Asp Ile Val Ala Asn His Ser Thr Ser Thr Trp Glu Tyr Phe Val Asp 
        115                 120                 125             


Gly Arg Leu His Thr Thr Ile Asp Asp Lys Gly Ala Leu Pro Pro Asn 
    130                 135                 140                 


Arg Phe Thr His Thr Ile Asn Asn Leu Pro Glu Gly Asn His Lys Ile 
145                 150                 155                 160 


Phe Val Arg Trp Asn Ile Ala Asp Thr Val Asn Ala Phe Tyr Gln Cys 
                165                 170                 175     


Ile Asp Ala Tyr Ile Thr Pro Gly Gly Thr Pro Gly Pro Thr Gln Gln 
            180                 185                 190         


Pro Thr Gln Gln Pro Thr Gln Gln Pro Thr Gln Gln Pro Thr Gln Gln 
        195                 200                 205             


Pro Thr Gln Gln Pro Thr Gln Gln Pro Thr Gln Gln Pro Gly Asn Gly 
    210                 215                 220                 


Ala Cys Thr Ala Thr Phe Lys Thr Asn Asn Ala Trp Gly Asn Gly Tyr 
225                 230                 235                 240 


Gln Gly Glu Ile Thr Val Thr Ala Gly Ser Ser Ala Ile Arg Gly Trp 
                245                 250                 255     


Lys Val Thr Val Asn Gly Ala Thr Ile Thr Gln Ala Trp Ser Ser Gln 
            260                 265                 270         


Leu Ser Gly Ser Thr Leu Ser Asn Ala Ser Trp Asn Gly Ser Leu Asn 
        275                 280                 285             


Ala Gly Ala Ser Thr Thr Leu Gly Phe Ile Ala Asn Gly Thr Pro Ser 
    290                 295                 300                 


Gly Val Thr Ala Thr Cys Ala Ala Ala 
305                 310             


<210>  12
<211>  397
<212>  PRT
<213>  Cellvibrio japonicus Ueda 107

<400>  12

Met Phe Asn Thr Arg His Leu Leu Ala Gly Val Ser Gln Leu Val Lys 
1               5                   10                  15      


Pro Ala Ser Met Met Ile Leu Ala Met Ala Ser Thr Leu Ala Ile His 
            20                  25                  30          


Glu Ala Ser Ala His Gly Tyr Val Ser Ser Pro Lys Ser Arg Val Ile 
        35                  40                  45              


Gln Cys Lys Glu Asn Gly Ile Glu Asn Pro Thr His Pro Ala Cys Ile 
    50                  55                  60                  


Ala Ala Lys Ala Ala Gly Asn Gly Gly Leu Tyr Thr Pro Gln Glu Val 
65                  70                  75                  80  


Ala Val Gly Gly Val Arg Asp Asn His Asp Tyr Tyr Ile Pro Asp Gly 
                85                  90                  95      


Arg Leu Cys Ser Ala Asn Arg Ala Asn Leu Phe Gly Met Asp Leu Ala 
            100                 105                 110         


Arg Asn Asp Trp Pro Ala Thr Ser Val Thr Pro Gly Ala Arg Glu Phe 
        115                 120                 125             


Val Trp Thr Asn Thr Ala Ala His Lys Thr Lys Tyr Phe Arg Tyr Tyr 
    130                 135                 140                 


Ile Thr Pro Gln Gly Tyr Asp His Ser Gln Pro Leu Arg Trp Ser Asp 
145                 150                 155                 160 


Leu Gln Leu Ile His Asp Ser Gly Pro Ala Asp Gln Glu Trp Val Ser 
                165                 170                 175     


Thr His Asn Val Ile Leu Pro Tyr Arg Thr Gly Arg His Ile Ile Tyr 
            180                 185                 190         


Ser Ile Trp Gln Arg Asp Trp Asp Arg Asp Ala Ala Glu Gly Phe Tyr 
        195                 200                 205             


Gln Cys Ile Asp Val Asp Phe Gly Asn Gly Thr Gly Thr Gly Ser Ser 
    210                 215                 220                 


Ser Ser Val Ala Ser Ser Val Val Ser Ser Val Thr Ser Ser Ser Val 
225                 230                 235                 240 


Ala Ser Ser Val Ala Ser Ser Leu Ser Asn Asp Thr Cys Ala Thr Leu 
                245                 250                 255     


Pro Ser Trp Asp Ala Ser Thr Val Tyr Thr Asn Pro Gln Gln Val Lys 
            260                 265                 270         


His Asn Ser Lys Arg Tyr Gln Ala Asn Tyr Trp Thr Gln Asn Gln Asn 
        275                 280                 285             


Pro Ser Thr Asn Ser Gly Gln Tyr Gly Pro Trp Leu Asp Leu Gly Asn 
    290                 295                 300                 


Cys Val Thr Ser Gly Gly Ser Ser Ser Val Ala Ser Ser Ser Val Ala 
305                 310                 315                 320 


Ser Ser Val Ala Ser Ser Val Thr Ser Ser Val Ala Ser Ser Val Val 
                325                 330                 335     


Ser Gly Asn Cys Ile Ser Pro Val Tyr Val Asp Gly Ser Ser Tyr Ala 
            340                 345                 350         


Asn Asn Ala Leu Val Gln Asn Asn Gly Ser Glu Tyr Arg Cys Leu Val 
        355                 360                 365             


Gly Gly Trp Cys Thr Val Gly Gly Pro Tyr Ala Pro Gly Thr Gly Trp 
    370                 375                 380                 


Ala Trp Ala Asn Ala Trp Glu Leu Val Arg Ser Cys Gln 
385                 390                 395         


<210>  13
<211>  337
<212>  PRT
<213>  Cellvibrio japonicus Ueda 107

<400>  13

Met Asn Asn Lys Phe Val Lys Met Gly Gly Met Gly Ala Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ser Ala Leu Ser Phe Gly His Gly Phe Val Asp Ser Pro Gly 
            20                  25                  30          


Ala Arg Asn Tyr Phe Cys Gly Ala Val Thr Lys Pro Asp His Val Met 
        35                  40                  45              


Asn Gly Val Ala Arg Tyr Pro Glu Cys Ala Gly Ala Phe Ala Asn Asp 
    50                  55                  60                  


Phe Asn Gly Gly Tyr Ser Tyr Met Ser Val Leu Thr His His Gln Gly 
65                  70                  75                  80  


Arg Lys Val Leu Gly Pro Val Ala Arg Asn Val Cys Gly Phe Asp Ser 
                85                  90                  95      


Glu Thr Trp Asn Gly Gly Lys Thr Pro Trp Asp Asn Ala Ile Asn Trp 
            100                 105                 110         


Pro Val Asn Asn Ile Asn Ser Gly Thr Leu Thr Phe Ser Trp Asp Ile 
        115                 120                 125             


Ser Asn Gly Pro His Phe Asp Asp Thr Ser Asp Phe Arg Tyr Trp Ile 
    130                 135                 140                 


Thr Lys Pro Gly Phe Val Tyr Gln Val Gly Arg Glu Leu Thr Trp Ala 
145                 150                 155                 160 


Asp Phe Glu Asp Gln Pro Phe Cys Asp Leu Ala Tyr Asn Asp Asp Asn 
                165                 170                 175     


Pro Gly Ala Tyr Pro Asn Val Arg Ala Asp Lys Pro Asn Thr His Phe 
            180                 185                 190         


His Thr Thr Cys Thr Val Pro Ala Arg Thr Gly Arg His Val Ile Tyr 
        195                 200                 205             


Ala Glu Trp Gly Arg Glu Pro Pro Thr Tyr Glu Arg Phe His Gly Cys 
    210                 215                 220                 


Ile Asp Val Gln Ile Gly Gly Gly Ser Asn Ser Ser Val Pro Val Ser 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Arg Ser Ser Ser Ser Ser Ser Leu Ala Pro Ser 
                245                 250                 255     


Ser Ser Ser Arg Ser Ser Ser Ser Ser Ser Ser Val Ser Ser Ser Arg 
            260                 265                 270         


Ser Ser Ser Ser Ser Val Val Ser Ser Ser Ser Ser Ser Arg Pro Ala 
        275                 280                 285             


Ser Ser Ser Ser Ser Ser Thr Gly Gly Ser Thr Glu Tyr Cys Asn Trp 
    290                 295                 300                 


Tyr Gly Trp Gln Val Ala Ile Cys Lys Asn Thr Thr Ser Gly Trp Ser 
305                 310                 315                 320 


Asn Glu Asn Gln Gln Thr Cys Ile Gly Arg Asp Thr Cys Asn Ala Pro 
                325                 330                 335     


Arg 
    


<210>  14
<211>  356
<212>  PRT
<213>  Streptomyces coelicolor A3(2)

<400>  14

Met Pro Ala Pro Ser Ala Ser Arg Arg Ala Ala Ala Val Ala Val Ala 
1               5                   10                  15      


Gly Leu Ala Pro Leu Ala Leu Thr Thr Leu Ala Ala Ala Pro Ala Ser 
            20                  25                  30          


Ala His Gly Ser Met Gly Asp Pro Val Ser Arg Val Ser Gln Cys His 
        35                  40                  45              


Ala Glu Gly Pro Glu Asn Pro Lys Ser Ala Ala Cys Arg Ala Ala Val 
    50                  55                  60                  


Ala Ala Gly Gly Thr Gln Ala Leu Tyr Asp Trp Asn Gly Ile Arg Ile 
65                  70                  75                  80  


Gly Asn Ala Ala Gly Lys His Gln Glu Leu Ile Pro Asp Gly Arg Leu 
                85                  90                  95      


Cys Ser Ala Asn Asp Pro Ala Phe Lys Gly Leu Asp Leu Ala Arg Ala 
            100                 105                 110         


Asp Trp Pro Ala Thr Gly Val Ser Ser Gly Ser Tyr Thr Phe Lys Tyr 
        115                 120                 125             


Arg Val Thr Ala Pro His Lys Gly Thr Phe Lys Val Tyr Leu Thr Lys 
    130                 135                 140                 


Pro Gly Tyr Asp Pro Ser Lys Pro Leu Gly Trp Gly Asp Leu Asp Leu 
145                 150                 155                 160 


Ser Ala Pro Val Ala Thr Ser Thr Asp Pro Val Ala Ser Gly Gly Phe 
                165                 170                 175     


Tyr Thr Phe Ser Gly Thr Leu Pro Glu Arg Ser Gly Lys His Leu Leu 
            180                 185                 190         


Tyr Ala Val Trp Gln Arg Ser Asp Ser Pro Glu Ala Phe Tyr Ser Cys 
        195                 200                 205             


Ser Asp Val Thr Phe Gly Gly Asp Gly Asp Gly Asp Gly Asp Gly Gly 
    210                 215                 220                 


Ser Gly Ser Gly Ala Ala Thr Gly Asp Asp Thr Ala Ser Gly Asp Ala 
225                 230                 235                 240 


Glu Ala Gly Ala Ala Pro Ala Pro Glu Ala Ser Ala Pro Ser Glu Glu 
                245                 250                 255     


Gln Leu Ala Ala Ala Ala Glu Lys Ser Thr Ile Glu His His Gly His 
            260                 265                 270         


Gly Asp Gln Asp Ala Ala Thr Thr Thr Asp Pro Thr Asp Pro Ala Ala 
        275                 280                 285             


Ala Pro Glu Glu Ala Pro Gly Thr Ala Ala Glu Pro His Gln Val Lys 
    290                 295                 300                 


Ala Ala Gly Gly Gly Thr Glu Asn Leu Ala Glu Thr Gly Gly Asp Ser 
305                 310                 315                 320 


Thr Thr Pro Tyr Ile Ala Val Gly Gly Ala Ala Ala Leu Ala Leu Gly 
                325                 330                 335     


Ala Ala Val Leu Phe Ala Ser Val Arg Arg Arg Ala Thr Thr Gly Gly 
            340                 345                 350         


Arg His Gly His 
        355     


<210>  15
<211>  323
<212>  PRT
<213>  Hypocrea jecorina

<400>  15

His Gly His Ile Asn Asp Ile Val Ile Asn Gly Val Trp Tyr Gln Ala 
1               5                   10                  15      


Tyr Asp Pro Thr Thr Phe Pro Tyr Glu Ser Asn Pro Pro Ile Val Val 
            20                  25                  30          


Gly Trp Thr Ala Ala Asp Leu Asp Asn Gly Phe Val Ser Pro Asp Ala 
        35                  40                  45              


Tyr Gln Asn Pro Asp Ile Ile Cys His Lys Asn Ala Thr Asn Ala Lys 
    50                  55                  60                  


Gly His Ala Ser Val Lys Ala Gly Asp Thr Ile Leu Phe Gln Trp Val 
65                  70                  75                  80  


Pro Val Pro Trp Pro His Pro Gly Pro Ile Val Asp Tyr Leu Ala Asn 
                85                  90                  95      


Cys Asn Gly Asp Cys Glu Thr Val Asp Lys Thr Thr Leu Glu Phe Phe 
            100                 105                 110         


Lys Ile Asp Gly Val Gly Leu Leu Ser Gly Gly Asp Pro Gly Thr Trp 
        115                 120                 125             


Ala Ser Asp Val Leu Ile Ser Asn Asn Asn Thr Trp Val Val Lys Ile 
    130                 135                 140                 


Pro Asp Asn Leu Ala Pro Gly Asn Tyr Val Leu Arg His Glu Ile Ile 
145                 150                 155                 160 


Ala Leu His Ser Ala Gly Gln Ala Asn Gly Ala Gln Asn Tyr Pro Gln 
                165                 170                 175     


Cys Phe Asn Ile Ala Val Ser Gly Ser Gly Ser Leu Gln Pro Ser Gly 
            180                 185                 190         


Val Leu Gly Thr Asp Leu Tyr His Ala Thr Asp Pro Gly Val Leu Ile 
        195                 200                 205             


Asn Ile Tyr Thr Ser Pro Leu Asn Tyr Ile Ile Pro Gly Pro Thr Val 
    210                 215                 220                 


Val Ser Gly Leu Pro Thr Ser Val Ala Gln Gly Ser Ser Ala Ala Thr 
225                 230                 235                 240 


Ala Thr Ala Ser Ala Thr Val Pro Gly Gly Gly Ser Gly Pro Thr Ser 
                245                 250                 255     


Arg Thr Thr Thr Thr Ala Arg Thr Thr Gln Ala Ser Ser Arg Pro Ser 
            260                 265                 270         


Ser Thr Pro Pro Ala Thr Thr Ser Ala Pro Ala Gly Gly Pro Thr Gln 
        275                 280                 285             


Thr Leu Tyr Gly Gln Cys Gly Gly Ser Gly Tyr Ser Gly Pro Thr Arg 
    290                 295                 300                 


Cys Ala Pro Pro Ala Thr Cys Ser Thr Leu Asn Pro Tyr Tyr Ala Gln 
305                 310                 315                 320 


Cys Leu Asn 
            


<210>  16
<211>  228
<212>  PRT
<213>  Hypocrea jecorina

<400>  16

His Gly Gln Val Gln Asn Phe Thr Ile Asn Gly Gln Tyr Asn Gln Gly 
1               5                   10                  15      


Phe Ile Leu Asp Tyr Tyr Tyr Gln Lys Gln Asn Thr Gly His Phe Pro 
            20                  25                  30          


Asn Val Ala Gly Trp Tyr Ala Glu Asp Leu Asp Leu Gly Phe Ile Ser 
        35                  40                  45              


Pro Asp Gln Tyr Thr Thr Pro Asp Ile Val Cys His Lys Asn Ala Ala 
    50                  55                  60                  


Pro Gly Ala Ile Ser Ala Thr Ala Ala Ala Gly Ser Asn Ile Val Phe 
65                  70                  75                  80  


Gln Trp Gly Pro Gly Val Trp Pro His Pro Tyr Gly Pro Ile Val Thr 
                85                  90                  95      


Tyr Val Val Glu Cys Ser Gly Ser Cys Thr Thr Val Asn Lys Asn Asn 
            100                 105                 110         


Leu Arg Trp Val Lys Ile Gln Glu Ala Gly Ile Asn Tyr Asn Thr Gln 
        115                 120                 125             


Val Trp Ala Gln Gln Asp Leu Ile Asn Gln Gly Asn Lys Trp Thr Val 
    130                 135                 140                 


Lys Ile Pro Ser Ser Leu Arg Pro Gly Asn Tyr Val Phe Arg His Glu 
145                 150                 155                 160 


Leu Leu Ala Ala His Gly Ala Ser Ser Ala Asn Gly Met Gln Asn Tyr 
                165                 170                 175     


Pro Gln Cys Val Asn Ile Ala Val Thr Gly Ser Gly Thr Lys Ala Leu 
            180                 185                 190         


Pro Ala Gly Thr Pro Ala Thr Gln Leu Tyr Lys Pro Thr Asp Pro Gly 
        195                 200                 205             


Ile Leu Phe Asn Pro Tyr Thr Thr Ile Thr Ser Tyr Thr Ile Pro Gly 
    210                 215                 220                 


Pro Ala Leu Trp 
225             


<210>  17
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  17
cgaagatcta cgcctctgcc tttggttc                                          28


<210>  18
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  18
gagacgtggt cgtatgtatg tgcgccgact tgatg                                  35


<210>  19
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  19
caagtcggcg cacatacata cgaccacgtc tccctcc                                37


<210>  20
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  20
ccaacagtcg tagctatcaa ccctcgagca ttaac                                  35


<210>  21
<211>  70
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  21
cagaagcttt caatgatacc acgcaatctc tccatcaccg agacaatcac caacagtcgt       60

agctatcaac                                                              70


<210>  22
<211>  196
<212>  PRT
<213>  Streptomyces coelicolor

<400>  22

His Gly Val Ala Met Met Pro Gly Ser Arg Thr Tyr Leu Cys Gln Leu 
1               5                   10                  15      


Asp Ala Lys Thr Gly Thr Gly Ala Leu Asp Pro Thr Asn Pro Ala Cys 
            20                  25                  30          


Gln Ala Ala Leu Asp Gln Ser Gly Ala Thr Ala Leu Tyr Asn Trp Phe 
        35                  40                  45              


Ala Val Leu Asp Ser Asn Ala Gly Gly Arg Gly Ala Gly Tyr Val Pro 
    50                  55                  60                  


Asp Gly Thr Leu Cys Ser Ala Gly Asp Arg Ser Pro Tyr Asp Phe Ser 
65                  70                  75                  80  


Ala Tyr Asn Ala Ala Arg Ser Asp Trp Pro Arg Thr His Leu Thr Ser 
                85                  90                  95      


Gly Ala Thr Ile Pro Val Glu Tyr Ser Asn Trp Ala Ala His Pro Gly 
            100                 105                 110         


Asp Phe Arg Val Tyr Leu Thr Lys Pro Gly Trp Ser Pro Thr Ser Glu 
        115                 120                 125             


Leu Gly Trp Asp Asp Leu Glu Leu Ile Gln Thr Val Thr Asn Pro Pro 
    130                 135                 140                 


Gln Gln Gly Ser Pro Gly Thr Asp Gly Gly His Tyr Tyr Trp Asp Leu 
145                 150                 155                 160 


Ala Leu Pro Ser Gly Arg Ser Gly Asp Ala Leu Ile Phe Met Gln Trp 
                165                 170                 175     


Val Arg Ser Asp Ser Gln Glu Asn Phe Phe Ser Cys Ser Asp Val Val 
            180                 185                 190         


Phe Asp Gly Gly 
        195     


